miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-375 ABCA8 -3.07641574130359 1.01411669962478e-67 0.439119649997109 0.0193184334483931 miRanda -0.251967930977536 1.23992021061119e-10 NA NA NA hsa-miR-375 ABCD3 -3.07641574130359 1.01411669962478e-67 0.508705811827904 1.35453162297024e-14 miRanda -0.102707814609006 2.23615968629263e-13 NA NA NA hsa-miR-375 ABHD4 -3.07641574130359 1.01411669962478e-67 0.469083905483153 6.55778204046024e-11 miRNAWalker2_validate -0.139876569501222 5.69642430225409e-21 NA NA NA hsa-miR-375 ABHD6 -3.07641574130359 1.01411669962478e-67 0.957172966255986 3.86331069118442e-30 miRanda -0.262531856486262 3.41141349272772e-54 NA NA NA hsa-miR-17-5p ACSF2 -1.75236465070226 3.95158641627966e-36 1.59048329518818 3.75316192785524e-20 TargetScan -0.368570943972181 2.04866128260036e-13 NA NA NA hsa-miR-26b-5p ACSF2 -0.737437044119268 6.43607077094955e-18 1.59048329518818 3.75316192785524e-20 miRNAWalker2_validate -0.244637016910955 0.00512496009679805 NA NA NA hsa-miR-375 ACSL4 -3.07641574130359 1.01411669962478e-67 1.19463967492977 3.63452848993709e-21 miRNAWalker2_validate;miRanda -0.337397902613109 7.18999422869242e-39 NA NA NA hsa-miR-375 ACSL5 -3.07641574130359 1.01411669962478e-67 0.0705965703283136 0.721516053732134 miRNATAP -0.192166287324859 3.84571709792672e-06 NA NA NA hsa-miR-375 ADAM22 -3.07641574130359 1.01411669962478e-67 1.06286238775823 1.1235119935098e-05 miRanda -0.386047055879454 1.90584765499027e-14 NA NA NA hsa-miR-375 ADCY3 -3.07641574130359 1.01411669962478e-67 0.587019581956137 1.19710845800569e-09 miRanda -0.230714976729081 3.37500281481208e-32 NA NA NA hsa-miR-375 AGPS -3.07641574130359 1.01411669962478e-67 0.879169533209154 8.6616485865946e-15 miRNATAP -0.243761745311303 3.48082566604209e-25 NA NA NA hsa-miR-375 AHDC1 -3.07641574130359 1.01411669962478e-67 0.632938233820616 3.66319212965188e-15 miRanda -0.205909504433901 1.55902939918971e-36 NA NA NA hsa-miR-375 AHR -3.07641574130359 1.01411669962478e-67 1.067602761387 3.18778544287946e-14 miRanda;miRNATAP -0.36718101563193 3.09135646087182e-38 NA NA NA hsa-miR-375 AKAP6 -3.07641574130359 1.01411669962478e-67 0.907824552582333 4.83023638670249e-10 miRanda -0.262235858067603 6.78235621675181e-18 NA NA NA hsa-miR-142-3p ALDH1A2 -0.668342567225765 0.000202408167795488 1.81305206186416 5.92381081720491e-19 PITA;miRanda -0.190090239385359 0.000128030672235849 NA NA NA hsa-miR-362-3p ALDH1A2 -0.332355427232084 0.0356765384646951 1.81305206186416 5.92381081720491e-19 miRanda -0.144001096490575 0.0125000675308098 NA NA NA hsa-miR-107 ALDH3B2 0.0765084476717224 0.299642610307981 -1.11364651069795 2.63766979705575e-06 miRanda -0.382219002252589 0.0064240768267627 NA NA NA hsa-miR-24-3p ALDH3B2 0.460804468884131 9.35756069405521e-09 -1.11364651069795 2.63766979705575e-06 MirTarget -0.530276379379495 2.61263554970712e-05 NA NA NA hsa-miR-455-5p ALDH3B2 0.485855374388112 0.000213721591485799 -1.11364651069795 2.63766979705575e-06 miRanda -0.223969716264601 0.00389009969111395 NA NA NA hsa-miR-542-3p ALDH3B2 0.31864941892079 0.0301489241026756 -1.11364651069795 2.63766979705575e-06 miRanda -0.200339542224513 0.00390326788854435 NA NA NA hsa-miR-375 ANKMY2 -3.07641574130359 1.01411669962478e-67 0.617699859120926 1.90825774212421e-27 miRNATAP -0.153566441811815 4.57633378291199e-39 NA NA NA hsa-miR-375 ANKRD1 -3.07641574130359 1.01411669962478e-67 0.549921608159876 0.187754962860845 miRNAWalker2_validate -0.296051490250115 0.000786474868146055 NA NA NA hsa-miR-375 ANKRD44 -3.07641574130359 1.01411669962478e-67 0.886288504934181 3.42147258327269e-07 miRanda -0.312677936672929 4.16540434174187e-18 NA NA NA hsa-let-7a-3p ANO4 -0.885792199222571 4.41035630133324e-17 1.67633776953313 3.09098215307792e-12 MirTarget;miRNATAP -0.879087591385369 4.25715479359052e-21 NA NA NA hsa-let-7b-3p ANO4 -0.506893427781244 8.27914591468333e-08 1.67633776953313 3.09098215307792e-12 MirTarget;miRNATAP -0.616993033682407 1.48094830474679e-08 NA NA NA hsa-let-7f-1-3p ANO4 -0.159920578752557 0.190200799823397 1.67633776953313 3.09098215307792e-12 MirTarget -0.273745629017755 0.00160508910436568 NA NA NA hsa-miR-217 ANO4 -0.647926571365963 0.000615546232893747 1.67633776953313 3.09098215307792e-12 miRanda -0.306462905318285 1.93282064970455e-08 NA NA NA hsa-miR-30b-5p ANO4 -1.16764575603669 1.75395013539893e-20 1.67633776953313 3.09098215307792e-12 MirTarget -0.654537507716167 5.06151204337199e-17 NA NA NA hsa-miR-30d-5p ANO4 -0.804765144490435 1.42480384315577e-16 1.67633776953313 3.09098215307792e-12 MirTarget;miRNATAP -0.877963728318402 6.6789620344489e-18 NA NA NA hsa-miR-324-5p ANO4 -0.539970285576229 1.69955273262756e-05 1.67633776953313 3.09098215307792e-12 miRanda -0.282721855086023 0.000645649166855651 NA NA NA hsa-miR-34c-5p ANO4 -0.411316782408141 0.0146968432653683 1.67633776953313 3.09098215307792e-12 miRanda -0.127185039241505 0.0414656990475733 NA NA NA hsa-miR-3607-3p ANO4 -1.16606393006353 2.28951370382029e-07 1.67633776953313 3.09098215307792e-12 MirTarget;miRNATAP -0.21950492526788 1.46747840427837e-06 NA NA NA hsa-miR-375 ANO4 -3.07641574130359 1.01411669962478e-67 1.67633776953313 3.09098215307792e-12 miRanda -0.413470595849289 2.90634532088291e-16 NA NA NA hsa-miR-590-3p ANO4 -0.58484153433625 1.6489232844135e-06 1.67633776953313 3.09098215307792e-12 miRanda -0.45678678091499 6.66655770200414e-08 NA NA NA hsa-miR-590-5p ANO4 -0.778106902153173 1.13576371947651e-09 1.67633776953313 3.09098215307792e-12 miRanda -0.56667923510975 8.78767889688367e-13 NA NA NA hsa-let-7a-3p ANO5 -0.885792199222571 4.41035630133324e-17 1.93083974402707 6.76548193977885e-18 mirMAP -1.04280999749085 4.08811091228703e-34 NA NA NA hsa-let-7b-3p ANO5 -0.506893427781244 8.27914591468333e-08 1.93083974402707 6.76548193977885e-18 mirMAP -0.792750667822009 5.20688231862407e-15 NA NA NA hsa-let-7f-1-3p ANO5 -0.159920578752557 0.190200799823397 1.93083974402707 6.76548193977885e-18 mirMAP -0.22009227906086 0.00720206600653621 NA NA NA hsa-miR-130b-5p ANO5 -1.15237450600836 1.6187151436434e-14 1.93083974402707 6.76548193977885e-18 MirTarget -0.670558190237324 3.97948739122772e-28 NA NA NA hsa-miR-141-3p ANO5 -1.79566520772936 2.43414267305203e-29 1.93083974402707 6.76548193977885e-18 mirMAP -0.761848596123895 1.02253167140764e-45 NA NA NA hsa-miR-146b-5p ANO5 -1.70281490248323 9.08060943822522e-35 1.93083974402707 6.76548193977885e-18 miRanda -0.362871310927731 4.11417917821155e-08 NA NA NA hsa-miR-16-1-3p ANO5 -0.6666012357419 1.3217954391766e-06 1.93083974402707 6.76548193977885e-18 mirMAP -0.375653234430649 1.24088374276877e-07 NA NA NA hsa-miR-186-5p ANO5 -0.567811924899222 1.37607142180843e-13 1.93083974402707 6.76548193977885e-18 mirMAP -1.10812174864806 1.89498798334041e-19 NA NA NA hsa-miR-217 ANO5 -0.647926571365963 0.000615546232893747 1.93083974402707 6.76548193977885e-18 miRanda -0.203594983244949 8.49797259379755e-05 NA NA NA hsa-miR-3065-3p ANO5 -1.23044918674587 2.31797828811622e-15 1.93083974402707 6.76548193977885e-18 MirTarget -0.366349943708841 2.03295513227218e-09 NA NA NA hsa-miR-30c-5p ANO5 -0.746747513281496 1.32431877874928e-12 1.93083974402707 6.76548193977885e-18 miRNATAP -0.418532652583145 4.92094595209816e-06 NA NA NA hsa-miR-30d-3p ANO5 -0.917692758870647 7.72239658481192e-16 1.93083974402707 6.76548193977885e-18 mirMAP -0.935935998292223 8.72144197083933e-32 NA NA NA hsa-miR-30d-5p ANO5 -0.804765144490435 1.42480384315577e-16 1.93083974402707 6.76548193977885e-18 miRNATAP -1.13223742777233 3.61477095588869e-34 NA NA NA hsa-miR-33a-3p ANO5 -0.612459021907227 0.000347410219059134 1.93083974402707 6.76548193977885e-18 mirMAP -0.456834661414066 1.46358151454168e-15 NA NA NA hsa-miR-374a-3p ANO5 -0.613148065516008 1.92239481728419e-11 1.93083974402707 6.76548193977885e-18 mirMAP -0.327901741689572 0.00211258179766282 NA NA NA hsa-miR-590-3p ANO5 -0.58484153433625 1.6489232844135e-06 1.93083974402707 6.76548193977885e-18 miRanda;mirMAP -0.568349670091828 5.9843296948506e-13 NA NA NA hsa-miR-590-5p ANO5 -0.778106902153173 1.13576371947651e-09 1.93083974402707 6.76548193977885e-18 miRanda -0.636220254385966 7.87204474242329e-18 NA NA NA hsa-miR-625-3p ANO5 -0.749969332494 2.25550410467727e-14 1.93083974402707 6.76548193977885e-18 mirMAP -0.653712101562804 1.49829815560355e-11 NA NA NA hsa-miR-629-5p ANO5 -1.11274734579886 7.79513509275813e-24 1.93083974402707 6.76548193977885e-18 MirTarget -1.03166633523992 4.18018134210785e-38 NA NA NA hsa-miR-664a-3p ANO5 -0.771665734879283 3.09460128204882e-14 1.93083974402707 6.76548193977885e-18 mirMAP -0.65323338152666 2.79160973039274e-12 NA NA NA hsa-miR-7-1-3p ANO5 -1.45703750327525 1.75378847810364e-30 1.93083974402707 6.76548193977885e-18 mirMAP -0.789409317821388 8.99519595785551e-30 NA NA NA hsa-miR-942-5p ANO5 -0.379108527613044 0.00732116056229795 1.93083974402707 6.76548193977885e-18 MirTarget -0.399771777119258 9.68537630798066e-09 NA NA NA hsa-miR-26b-5p AOX1 -0.737437044119268 6.43607077094955e-18 2.6760602627649 1.65276122334927e-31 miRNAWalker2_validate -1.01727968261542 7.64708809247327e-19 NA NA NA hsa-miR-320a AOX1 -0.995486653328464 1.19389676663012e-20 2.6760602627649 1.65276122334927e-31 miRanda -0.379767159040473 4.9272387691925e-05 NA NA NA hsa-miR-335-3p AOX1 -0.625191833097363 1.64208673352814e-06 2.6760602627649 1.65276122334927e-31 mirMAP -0.51852225464084 2.49382852513556e-11 NA NA NA hsa-miR-590-3p AOX1 -0.58484153433625 1.6489232844135e-06 2.6760602627649 1.65276122334927e-31 miRanda -0.67135917182821 3.87143281112003e-16 NA NA NA hsa-miR-664a-3p AOX1 -0.771665734879283 3.09460128204882e-14 2.6760602627649 1.65276122334927e-31 mirMAP -0.677817126265173 5.51320623207091e-12 NA NA NA hsa-miR-375 APBB1IP -3.07641574130359 1.01411669962478e-67 0.141012299436801 0.332764355673397 miRanda;miRNATAP -0.194807593273109 1.28572459981416e-10 NA NA NA hsa-miR-375 APLF -3.07641574130359 1.01411669962478e-67 0.910654723284938 3.17570884738455e-14 miRanda -0.285658535540454 2.83309954149962e-31 NA NA NA hsa-miR-375 APOB -3.07641574130359 1.01411669962478e-67 1.73432359516872 9.65055813639168e-12 miRanda -0.558784653403553 1.48249888743616e-26 NA NA NA hsa-miR-375 AQP4 -3.07641574130359 1.01411669962478e-67 1.1019605868947 1.19605500256421e-08 miRanda -0.187179871911019 5.5934378684321e-06 NA NA NA hsa-miR-375 ARL4C -3.07641574130359 1.01411669962478e-67 0.776239816516583 7.13614566575246e-11 MirTarget;miRNATAP -0.240080230545212 2.06010029968132e-22 NA NA NA hsa-miR-16-2-3p ARMCX1 -0.615426607127207 4.13943192730969e-05 1.60430999924951 5.52290519922558e-18 mirMAP -0.354058345298857 8.73089821532448e-11 NA NA NA hsa-miR-21-5p ARMCX1 -1.03478217459823 8.05139001472981e-27 1.60430999924951 5.52290519922558e-18 MirTarget -0.560240368177485 1.85780510258819e-12 NA NA NA hsa-miR-324-5p ARMCX1 -0.539970285576229 1.69955273262756e-05 1.60430999924951 5.52290519922558e-18 miRanda -0.253464823860346 8.7886533686e-05 NA NA NA hsa-miR-590-5p ARMCX1 -0.778106902153173 1.13576371947651e-09 1.60430999924951 5.52290519922558e-18 MirTarget;miRanda;miRNATAP -0.500419086662081 4.10922426733653e-16 NA NA NA hsa-miR-7-1-3p ARMCX1 -1.45703750327525 1.75378847810364e-30 1.60430999924951 5.52290519922558e-18 MirTarget -0.617686086348894 2.21770229525043e-26 NA NA NA hsa-miR-375 ARNTL2 -3.07641574130359 1.01411669962478e-67 0.751885162487626 0.000804940074104568 miRNAWalker2_validate -0.309539963200399 4.0727513790659e-11 NA NA NA hsa-miR-375 AS3MT -3.07641574130359 1.01411669962478e-67 0.713426686936629 2.90588388552401e-07 miRanda -0.11907767704451 5.82153866162941e-05 NA NA NA hsa-miR-375 ATF7IP -3.07641574130359 1.01411669962478e-67 0.547433202941601 1.26038353638369e-06 miRanda -0.148289946611044 4.42916974410818e-10 NA NA NA hsa-miR-375 ATP1B1 -3.07641574130359 1.01411669962478e-67 1.16599763634461 1.13225905572803e-17 miRanda;miRNATAP -0.348449811776406 5.55323328572821e-36 NA NA NA hsa-let-7a-5p ATP8B4 -0.810823676990507 1.01381033479519e-26 0.788054440682087 0.000502647644695433 MirTarget;TargetScan -0.541015673239193 9.97493664316089e-06 NA NA NA hsa-let-7b-5p ATP8B4 -0.221439854958536 0.00904814983284487 0.788054440682087 0.000502647644695433 MirTarget -0.352907648412283 0.00216990308229785 NA NA NA hsa-let-7d-5p ATP8B4 -0.767545769968654 1.765411565791e-19 0.788054440682087 0.000502647644695433 MirTarget -0.543162421464728 8.31309649810361e-07 NA NA NA hsa-let-7e-5p ATP8B4 -0.43840772282889 6.33224012337383e-08 0.788054440682087 0.000502647644695433 MirTarget -0.575576930033174 1.21609076074581e-06 NA NA NA hsa-let-7f-5p ATP8B4 -0.832261132545632 1.30765336262194e-16 0.788054440682087 0.000502647644695433 MirTarget -0.250221176527423 0.00787063317721837 NA NA NA hsa-let-7g-5p ATP8B4 -0.614367845078204 1.65972787509666e-17 0.788054440682087 0.000502647644695433 MirTarget -0.26573059990572 0.0444579936709765 NA NA NA hsa-miR-125a-5p ATP8B4 -0.0743450557019045 0.423845877863826 0.788054440682087 0.000502647644695433 miRanda -0.216462901857928 0.0399818441004454 NA NA NA hsa-miR-129-5p ATP8B4 0.664119897121715 0.0020737112165816 0.788054440682087 0.000502647644695433 miRanda -0.136833615254514 0.00323891487294022 NA NA NA hsa-miR-200a-5p ATP8B4 -0.612785350735232 0.00678577753061689 0.788054440682087 0.000502647644695433 MirTarget -0.137439715261179 0.00127957049373519 NA NA NA hsa-miR-200b-5p ATP8B4 -0.369269569070792 0.0737621489480168 0.788054440682087 0.000502647644695433 MirTarget -0.120607486834741 0.0108530620073936 NA NA NA hsa-miR-217 ATP8B4 -0.647926571365963 0.000615546232893747 0.788054440682087 0.000502647644695433 miRanda -0.134929202387507 0.00830842709424956 NA NA NA hsa-miR-338-3p ATP8B4 -0.289775600192434 0.0820821857540406 0.788054440682087 0.000502647644695433 miRanda -0.19494263880783 0.000798416582668084 NA NA NA hsa-miR-671-5p ATP8B4 -1.21418487247953 1.04429628542981e-14 0.788054440682087 0.000502647644695433 MirTarget -0.283124647081831 6.94150155577762e-06 NA NA NA hsa-miR-375 AVPR1A -3.07641574130359 1.01411669962478e-67 1.04143523861994 4.15172815179025e-05 miRanda -0.393890715661036 1.01992716342186e-13 NA NA NA hsa-miR-375 AXL -3.07641574130359 1.01411669962478e-67 0.746825403155111 1.79953826439525e-09 miRNAWalker2_validate -0.308347289524978 5.44979623206992e-35 NA NA NA hsa-miR-375 BACH2 -3.07641574130359 1.01411669962478e-67 0.742739616345148 5.73828982988552e-07 miRNATAP -0.291612582308294 1.43742720005101e-21 NA NA NA hsa-miR-375 BAG4 -3.07641574130359 1.01411669962478e-67 0.798794538231488 7.09043635894388e-09 miRanda -0.202152426290554 3.4610336347307e-12 NA NA NA hsa-miR-375 BATF2 -3.07641574130359 1.01411669962478e-67 0.882036294524862 2.22518895703444e-08 miRNAWalker2_validate -0.36261234614782 9.48729205636479e-30 NA NA NA hsa-let-7a-3p BCL11A -0.885792199222571 4.41035630133324e-17 1.43950626973162 4.02156356683313e-10 mirMAP -0.35496310759019 0.000113252127777485 NA NA NA hsa-let-7b-3p BCL11A -0.506893427781244 8.27914591468333e-08 1.43950626973162 4.02156356683313e-10 mirMAP -0.474079479321869 5.61836702321949e-06 NA NA NA hsa-miR-126-5p BCL11A -0.222731872217005 0.0500978215521652 1.43950626973162 4.02156356683313e-10 mirMAP -0.377860784135473 1.63079514019283e-05 NA NA NA hsa-miR-140-5p BCL11A -0.714046975295031 8.18104415848501e-20 1.43950626973162 4.02156356683313e-10 PITA;miRanda;miRNATAP -0.399636968397121 0.00126722930615703 NA NA NA hsa-miR-144-5p BCL11A 0.137749469177914 0.421335804923689 1.43950626973162 4.02156356683313e-10 mirMAP -0.185891298892844 0.00142328152335829 NA NA NA hsa-miR-146b-5p BCL11A -1.70281490248323 9.08060943822522e-35 1.43950626973162 4.02156356683313e-10 miRanda;miRNATAP -0.164331327451378 0.0151307111777456 NA NA NA hsa-miR-148b-3p BCL11A -0.551634584599407 1.25985630163353e-10 1.43950626973162 4.02156356683313e-10 miRNAWalker2_validate -1.02263365589964 4.40552422482213e-20 NA NA NA hsa-miR-16-2-3p BCL11A -0.615426607127207 4.13943192730969e-05 1.43950626973162 4.02156356683313e-10 mirMAP -0.175441436076828 0.0095513921648218 NA NA NA hsa-miR-190a-5p BCL11A 0.163976032931052 0.241051169305023 1.43950626973162 4.02156356683313e-10 MirTarget -0.257694304418599 0.000318124187869951 NA NA NA hsa-miR-2355-5p BCL11A -0.280181037431566 0.00411194169830979 1.43950626973162 4.02156356683313e-10 miRNATAP -0.242001806469602 0.018472324423825 NA NA NA hsa-miR-25-3p BCL11A -1.48824362562015 5.9514552944435e-55 1.43950626973162 4.02156356683313e-10 MirTarget -0.594199394294555 1.91202225033718e-10 NA NA NA hsa-miR-26b-5p BCL11A -0.737437044119268 6.43607077094955e-18 1.43950626973162 4.02156356683313e-10 mirMAP -0.347123957017979 0.00230846807656849 NA NA NA hsa-miR-29c-3p BCL11A 0.0707692065669665 0.397653135713718 1.43950626973162 4.02156356683313e-10 miRNAWalker2_validate -0.424015520956343 0.000424115063242915 NA NA NA hsa-miR-30d-3p BCL11A -0.917692758870647 7.72239658481192e-16 1.43950626973162 4.02156356683313e-10 mirMAP -0.569842021802213 1.21288499029386e-11 NA NA NA hsa-miR-32-5p BCL11A -0.919129456898536 9.58217908367915e-12 1.43950626973162 4.02156356683313e-10 miRNAWalker2_validate;MirTarget -0.454820659133911 2.12862888109504e-10 NA NA NA hsa-miR-337-3p BCL11A -0.478962968119508 1.28994381704853e-05 1.43950626973162 4.02156356683313e-10 PITA;miRNATAP -0.421889296271149 2.7899929233464e-06 NA NA NA hsa-miR-33a-3p BCL11A -0.612459021907227 0.000347410219059134 1.43950626973162 4.02156356683313e-10 mirMAP -0.287176462640802 1.11288967514533e-06 NA NA NA hsa-miR-340-5p BCL11A -0.418767158937088 8.44911569437027e-06 1.43950626973162 4.02156356683313e-10 miRNAWalker2_validate;mirMAP -0.335836501295724 0.00152540220064201 NA NA NA hsa-miR-3607-3p BCL11A -1.16606393006353 2.28951370382029e-07 1.43950626973162 4.02156356683313e-10 mirMAP;miRNATAP -0.175180294972437 5.87849820740149e-05 NA NA NA hsa-miR-362-3p BCL11A -0.332355427232084 0.0356765384646951 1.43950626973162 4.02156356683313e-10 miRanda -0.190993130819827 0.00278504819090596 NA NA NA hsa-miR-362-5p BCL11A -1.31930944822897 5.90925525397408e-17 1.43950626973162 4.02156356683313e-10 PITA -0.165596492082528 0.00706265329749845 NA NA NA hsa-miR-363-3p BCL11A -1.00269053441578 1.08997020195393e-10 1.43950626973162 4.02156356683313e-10 MirTarget -0.12852348388672 0.0422703821172327 NA NA NA hsa-miR-484 BCL11A -0.968911692345789 2.45789986401529e-17 1.43950626973162 4.02156356683313e-10 PITA -0.632095126938072 2.56583207621071e-14 NA NA NA hsa-miR-486-5p BCL11A 0.572011250438858 0.00125387759748306 1.43950626973162 4.02156356683313e-10 miRanda -0.141309976058564 0.0118408561587734 NA NA NA hsa-miR-539-5p BCL11A -0.199350141954634 0.252691751194608 1.43950626973162 4.02156356683313e-10 MirTarget -0.256597171473526 1.2068162127722e-05 NA NA NA hsa-miR-590-3p BCL11A -0.58484153433625 1.6489232844135e-06 1.43950626973162 4.02156356683313e-10 miRanda;mirMAP -0.308202356618788 0.000147390620000115 NA NA NA hsa-miR-590-5p BCL11A -0.778106902153173 1.13576371947651e-09 1.43950626973162 4.02156356683313e-10 PITA;miRanda;miRNATAP -0.438394896433171 8.79391540648779e-09 NA NA NA hsa-miR-7-1-3p BCL11A -1.45703750327525 1.75378847810364e-30 1.43950626973162 4.02156356683313e-10 MirTarget;mirMAP -0.544578686298078 7.23470147478085e-14 NA NA NA hsa-miR-92a-3p BCL11A -1.46190744133 3.47140194919109e-41 1.43950626973162 4.02156356683313e-10 MirTarget -0.493130697989906 4.55181352245117e-09 NA NA NA hsa-miR-375 BCL11B -3.07641574130359 1.01411669962478e-67 0.600885203332586 0.000984580070050149 miRanda -0.302900337781515 1.01223233238526e-15 NA NA NA hsa-miR-375 BCL2 -3.07641574130359 1.01411669962478e-67 1.20400501263257 4.51412820200384e-17 miRNAWalker2_validate -0.376701413600904 2.68862032057592e-38 26381132;26697569;25613180 The levels of miR-375 Bax and Bcl-2 protein expression in treated cells were determined by Western blot and RT-PCR; Moreover compared to control group the expression of Bcl-2 and miR-375 decreases with formononetin in the U2OS cells while Bax increases;Exosome Carried microRNA 375 Inhibits Cell Progression and Dissemination via Bcl 2 Blocking in Colon Cancer; RT-PCR for Bcl-2 expression showed that Bcl-2 is down-regulated for miR-375 inhibitor and up-regulated for the miR-375 mimic a result confirmed by Western blotting; The present study brings to the forefront new data that suggest miR-375 as a new player in controlling the pathways responsible for inhibiting the natural history of CRC tumor cells via the Bcl-2 pathway;mRNA levels of ERα Bcl-2 and miR-375 were quantified using real-time polymerase chain reaction; After treatment with biochanin A ERα miR-375 and Bcl-2 expression was significantly upregulated ;progression; sarcoma;colon cancer;breast cancer hsa-miR-375 BCL6 -3.07641574130359 1.01411669962478e-67 0.358361413686158 0.000618258288809499 miRanda -0.11507075477873 1.73714013630988e-07 NA NA NA hsa-miR-375 BCO2 -3.07641574130359 1.01411669962478e-67 0.451222717172146 0.00247949664047187 miRanda -0.131269692266055 3.07859631203905e-05 NA NA NA hsa-miR-375 BDH2 -3.07641574130359 1.01411669962478e-67 1.0096712220767 4.36975258482986e-14 miRNAWalker2_validate -0.308799220233737 2.73840427075111e-29 NA NA NA hsa-miR-375 BEND6 -3.07641574130359 1.01411669962478e-67 0.832859970083694 1.40243838377899e-09 miRanda -0.248487634724027 4.24280878090283e-18 NA NA NA hsa-miR-133b BICD1 1.6405074687617 4.27792135252442e-19 -1.53723135435831 5.61855338233131e-17 miRanda -0.256325205785106 1.02578451866324e-09 NA NA NA hsa-miR-139-5p BICD1 0.248477989074289 0.0406493945332509 -1.53723135435831 5.61855338233131e-17 miRanda -0.29175574049274 1.08298869294683e-05 NA NA NA hsa-miR-143-3p BICD1 1.04476349103255 1.53710742335757e-21 -1.53723135435831 5.61855338233131e-17 miRNATAP -0.346141017852353 9.26539867818303e-07 NA NA NA hsa-miR-154-5p BICD1 0.0867937282451339 0.57344974065766 -1.53723135435831 5.61855338233131e-17 mirMAP -0.215191188370425 4.09392498030321e-05 NA NA NA hsa-miR-199a-5p BICD1 -0.56859326149571 4.98517644263078e-07 -1.53723135435831 5.61855338233131e-17 miRanda -0.142931587057545 0.044200425350693 NA NA NA hsa-miR-30c-5p BICD1 -0.746747513281496 1.32431877874928e-12 -1.53723135435831 5.61855338233131e-17 mirMAP -0.222988658653259 0.0030831226586772 NA NA NA hsa-miR-338-3p BICD1 -0.289775600192434 0.0820821857540406 -1.53723135435831 5.61855338233131e-17 miRanda -0.142214150127703 0.00331794193449275 NA NA NA hsa-miR-374a-5p BICD1 0.0315285733368933 0.724846989131115 -1.53723135435831 5.61855338233131e-17 mirMAP -0.187430313231169 0.0396311746155505 NA NA NA hsa-miR-374b-5p BICD1 -0.221226738167835 0.00747242957932152 -1.53723135435831 5.61855338233131e-17 mirMAP -0.286026508761947 0.00362843381800652 NA NA NA hsa-miR-409-3p BICD1 0.0985105482626563 0.373607618015637 -1.53723135435831 5.61855338233131e-17 mirMAP -0.182495057437901 0.0128278521182211 NA NA NA hsa-miR-450b-5p BICD1 0.857642158166269 2.78318878314148e-06 -1.53723135435831 5.61855338233131e-17 mirMAP -0.146190888061038 0.00081981253095837 NA NA NA hsa-miR-501-5p BICD1 -0.0408475609966014 0.781958453157052 -1.53723135435831 5.61855338233131e-17 mirMAP -0.178792985798588 0.00143890559797517 NA NA NA hsa-miR-508-3p BICD1 0.564537868062026 0.0283329210776803 -1.53723135435831 5.61855338233131e-17 mirMAP -0.202687706911357 2.32984870667641e-10 NA NA NA hsa-miR-375 BIN2 -3.07641574130359 1.01411669962478e-67 -0.0182464994479077 0.904792883634619 miRNATAP -0.139649671469219 1.3291611123555e-05 NA NA NA hsa-miR-375 BIRC3 -3.07641574130359 1.01411669962478e-67 0.333347040597572 0.0218505250015213 miRNAWalker2_validate -0.228481864925861 3.14904755315378e-14 23726271 Taken together these data suggest that miR-375 sensitizes TNF-α-induced apoptosis and the reduction in the expression of the apoptosis inhibitory proteins cFLIP-L and cIAP2 plays an important role in this sensitization head and neck cancer hsa-let-7a-5p BMP5 -0.810823676990507 1.01381033479519e-26 3.2120756946304 4.84719546676257e-10 TargetScan -1.4502631439688 2.60432807111817e-07 NA NA NA hsa-miR-33a-3p BMP5 -0.612459021907227 0.000347410219059134 3.2120756946304 4.84719546676257e-10 mirMAP -0.366602879841345 0.0059071253733191 NA NA NA hsa-miR-576-5p BMP5 -0.962105441345164 5.68435745070752e-14 3.2120756946304 4.84719546676257e-10 mirMAP -0.632258358417821 0.000209652150502047 NA NA NA hsa-miR-590-3p BMP5 -0.58484153433625 1.6489232844135e-06 3.2120756946304 4.84719546676257e-10 mirMAP -0.40376353727919 0.027234135982343 NA NA NA hsa-miR-375 BNC2 -3.07641574130359 1.01411669962478e-67 1.28815171128814 1.00280304698643e-15 miRNATAP -0.446823303106111 6.25928383870483e-44 NA NA NA hsa-miR-375 BVES -3.07641574130359 1.01411669962478e-67 1.17988413231118 5.68766305145643e-11 miRNATAP -0.3291298560408 2.11806919598713e-18 NA NA NA hsa-miR-375 C15orf41 -3.07641574130359 1.01411669962478e-67 1.34983715918569 1.69623713249549e-29 miRNATAP -0.355857030347246 5.21651809455957e-48 NA NA NA hsa-miR-375 C7 -3.07641574130359 1.01411669962478e-67 1.09947659500583 1.78570634284001e-06 miRanda;miRNATAP -0.418312387366061 1.61398906583432e-18 NA NA NA hsa-miR-100-5p CAMKK2 0.231007085450551 0.0155610142898595 -1.54933870735928 9.4734749952381e-27 miRNAWalker2_validate -0.42893240297122 1.8270524721366e-10 NA NA NA hsa-miR-133b CAMKK2 1.6405074687617 4.27792135252442e-19 -1.54933870735928 9.4734749952381e-27 miRanda -0.224727100725531 2.36320619692692e-11 NA NA NA hsa-miR-378a-5p CAMKK2 0.523580281526759 3.68329628218732e-06 -1.54933870735928 9.4734749952381e-27 MirTarget -0.131395494047047 0.021517234789395 NA NA NA hsa-miR-411-5p CAMKK2 0.453247731792584 0.000304820372202091 -1.54933870735928 9.4734749952381e-27 miRNATAP -0.297829782965634 5.12856549541245e-09 NA NA NA hsa-miR-92b-3p CAMKK2 -0.0515531008682384 0.658460162557115 -1.54933870735928 9.4734749952381e-27 miRNATAP -0.291787170323678 1.37930684500795e-07 NA NA NA hsa-miR-375 CCDC80 -3.07641574130359 1.01411669962478e-67 1.08880296481184 2.01695571931912e-10 miRanda -0.398812097858155 2.61353024702473e-30 NA NA NA hsa-miR-375 CCDC88A -3.07641574130359 1.01411669962478e-67 1.01004172144431 6.3031001082948e-16 miRNAWalker2_validate -0.319143630307883 3.72602886320981e-36 NA NA NA hsa-miR-375 CCL28 -3.07641574130359 1.01411669962478e-67 0.75730695727668 2.07044742636006e-06 miRanda -0.240743614256084 5.49906066850645e-13 NA NA NA hsa-miR-140-3p CD177 -0.589055604093291 1.70551761364582e-15 1.56593155695305 0.000931397694763466 mirMAP -0.581883724827276 0.0311617458141272 NA NA NA hsa-miR-199a-5p CD177 -0.56859326149571 4.98517644263078e-07 1.56593155695305 0.000931397694763466 miRanda -0.632397843821022 0.000367924215401204 NA NA NA hsa-miR-199b-5p CD177 -1.17761875205879 1.04905958983479e-17 1.56593155695305 0.000931397694763466 miRanda -0.477374023532344 0.000826937794710156 NA NA NA hsa-miR-218-5p CD177 0.0544415608694644 0.541072191147427 1.56593155695305 0.000931397694763466 mirMAP -0.510777563856553 0.0262242092348618 NA NA NA hsa-miR-324-5p CD177 -0.539970285576229 1.69955273262756e-05 1.56593155695305 0.000931397694763466 miRanda -0.709189592670573 9.00900601709329e-06 NA NA NA hsa-miR-339-5p CD177 -0.986556478524229 2.39294233177812e-12 1.56593155695305 0.000931397694763466 miRanda -0.926338300694883 2.48023750723027e-11 NA NA NA hsa-miR-361-5p CD177 -0.652200980992921 2.23302456529972e-21 1.56593155695305 0.000931397694763466 miRanda;miRNATAP -1.45611015633127 3.28215560020607e-07 NA NA NA hsa-miR-491-5p CD177 -0.996821208926168 6.43686029153545e-11 1.56593155695305 0.000931397694763466 MirTarget;miRanda -0.651068652108278 5.60602262981392e-07 NA NA NA hsa-miR-542-3p CD177 0.31864941892079 0.0301489241026756 1.56593155695305 0.000931397694763466 miRanda -0.672502500351052 8.89348396016826e-07 NA NA NA hsa-miR-375 CD200 -3.07641574130359 1.01411669962478e-67 1.39145771554778 4.05269599929285e-19 miRanda -0.416242900158827 2.05763138512642e-39 NA NA NA hsa-miR-375 CD3G -3.07641574130359 1.01411669962478e-67 0.284743381732858 0.23689095463201 miRanda -0.260656638663281 2.41453141591358e-07 NA NA NA hsa-miR-375 CDCA7L -3.07641574130359 1.01411669962478e-67 0.538515612164421 0.000400964652057543 miRNAWalker2_validate -0.120194302461856 0.000192742656431535 NA NA NA hsa-miR-375 CDKN2B -3.07641574130359 1.01411669962478e-67 0.525653789736722 2.70103772206395e-05 miRNAWalker2_validate;miRNATAP -0.168359211036099 1.44810067336792e-10 NA NA NA hsa-miR-375 CELF2 -3.07641574130359 1.01411669962478e-67 1.12140591356664 3.54252164779782e-14 miRNAWalker2_validate -0.345988846039739 4.75748597776046e-30 NA NA NA hsa-miR-148b-5p CFH -1.04534361724991 2.31801722055734e-12 1.03080287691366 2.97547954050824e-11 MirTarget -0.279072990322951 1.04542102958456e-09 NA NA NA hsa-miR-429 CFH -0.682420529994949 0.00462213397220848 1.03080287691366 2.97547954050824e-11 miRanda -0.110229305523301 7.28082121720394e-05 NA NA NA hsa-miR-590-3p CFH -0.58484153433625 1.6489232844135e-06 1.03080287691366 2.97547954050824e-11 miRanda;mirMAP -0.197452523825478 0.000317742089317624 NA NA NA hsa-miR-590-5p CFH -0.778106902153173 1.13576371947651e-09 1.03080287691366 2.97547954050824e-11 miRanda -0.2427446625115 2.65675174844022e-06 NA NA NA hsa-miR-375 CFL2 -3.07641574130359 1.01411669962478e-67 1.32868559918749 3.13047963736502e-29 miRNAWalker2_validate -0.336883146242309 2.05849989318975e-43 NA NA NA hsa-miR-375 CHGB -3.07641574130359 1.01411669962478e-67 1.61687607048837 2.26032958320157e-08 miRNAWalker2_validate -0.324391623614617 1.29129865116553e-07 NA NA NA hsa-miR-375 CHODL -3.07641574130359 1.01411669962478e-67 0.598892852477578 0.0160604388850619 miRanda -0.248391563145046 2.09658425055822e-06 NA NA NA hsa-miR-15b-3p CHRM3 -0.70449098511926 1.79992266779526e-09 -0.593827118566968 0.0790881059495277 mirMAP -0.303133614428033 0.0128396032780718 NA NA NA hsa-miR-16-2-3p CHRM3 -0.615426607127207 4.13943192730969e-05 -0.593827118566968 0.0790881059495277 mirMAP -0.506396735152586 1.74395052225437e-07 NA NA NA hsa-miR-186-5p CHRM3 -0.567811924899222 1.37607142180843e-13 -0.593827118566968 0.0790881059495277 mirMAP -0.539589336693354 0.00365427073048781 NA NA NA hsa-miR-218-5p CHRM3 0.0544415608694644 0.541072191147427 -0.593827118566968 0.0790881059495277 mirMAP -0.404886161910212 0.0133202245224572 NA NA NA hsa-miR-25-3p CHRM3 -1.48824362562015 5.9514552944435e-55 -0.593827118566968 0.0790881059495277 mirMAP -0.435485783926133 0.00144898013690875 NA NA NA hsa-miR-28-5p CHRM3 -0.142043455520843 0.0231808012790841 -0.593827118566968 0.0790881059495277 miRanda -0.627808437746476 0.00752618699719537 NA NA NA hsa-miR-30a-3p CHRM3 0.0513578942843456 0.646614247659862 -0.593827118566968 0.0790881059495277 mirMAP -0.310943032851795 0.0164223150256331 NA NA NA hsa-miR-30b-5p CHRM3 -1.16764575603669 1.75395013539893e-20 -0.593827118566968 0.0790881059495277 mirMAP -0.856782456385014 2.04576767955905e-15 NA NA NA hsa-miR-30c-5p CHRM3 -0.746747513281496 1.32431877874928e-12 -0.593827118566968 0.0790881059495277 mirMAP -0.78975355446924 2.9323788297124e-09 NA NA NA hsa-miR-30d-3p CHRM3 -0.917692758870647 7.72239658481192e-16 -0.593827118566968 0.0790881059495277 mirMAP -0.658041585707425 7.69451719100729e-08 NA NA NA hsa-miR-335-3p CHRM3 -0.625191833097363 1.64208673352814e-06 -0.593827118566968 0.0790881059495277 mirMAP -0.388251275566174 0.000396758406125999 NA NA NA hsa-miR-339-5p CHRM3 -0.986556478524229 2.39294233177812e-12 -0.593827118566968 0.0790881059495277 miRanda -0.436085043003742 1.29932440224639e-05 NA NA NA hsa-miR-362-5p CHRM3 -1.31930944822897 5.90925525397408e-17 -0.593827118566968 0.0790881059495277 TargetScan -0.453575301780348 2.59888821093778e-07 NA NA NA hsa-miR-374b-5p CHRM3 -0.221226738167835 0.00747242957932152 -0.593827118566968 0.0790881059495277 mirMAP -0.354269588406045 0.0442586112966328 NA NA NA hsa-miR-500a-5p CHRM3 -0.724031963091637 1.07520204401534e-07 -0.593827118566968 0.0790881059495277 mirMAP -0.350320724240898 0.000849382536552566 NA NA NA hsa-miR-532-3p CHRM3 -0.770066629498831 6.77162597488232e-10 -0.593827118566968 0.0790881059495277 mirMAP -0.309334629467316 0.00671215845518923 NA NA NA hsa-miR-532-5p CHRM3 -0.819279743754759 7.8621216315329e-15 -0.593827118566968 0.0790881059495277 mirMAP -0.486628537695005 0.000270086630786746 NA NA NA hsa-miR-542-3p CHRM3 0.31864941892079 0.0301489241026756 -0.593827118566968 0.0790881059495277 mirMAP -0.458035297926079 2.66849705988537e-06 NA NA NA hsa-miR-576-5p CHRM3 -0.962105441345164 5.68435745070752e-14 -0.593827118566968 0.0790881059495277 mirMAP -0.312715486597287 0.00455787649828132 NA NA NA hsa-miR-590-3p CHRM3 -0.58484153433625 1.6489232844135e-06 -0.593827118566968 0.0790881059495277 miRanda;mirMAP -0.467916992433278 6.61791272608761e-05 NA NA NA hsa-miR-664a-3p CHRM3 -0.771665734879283 3.09460128204882e-14 -0.593827118566968 0.0790881059495277 mirMAP -0.287215036918897 0.0394537028823065 NA NA NA hsa-miR-375 CHRNA7 -3.07641574130359 1.01411669962478e-67 1.90343526456864 1.41235573198642e-10 mirMAP -0.425188226919456 1.28910178507897e-11 NA NA NA hsa-miR-375 CLCA2 -3.07641574130359 1.01411669962478e-67 3.74783792542163 3.98195579781602e-22 MirTarget;miRanda -0.792599000323779 5.37667500109007e-22 NA NA NA hsa-miR-375 CLCA4 -3.07641574130359 1.01411669962478e-67 2.7943929796298 4.9325802612242e-11 miRNATAP -0.620832129917255 5.27404444258679e-12 NA NA NA hsa-miR-375 CLDN1 -3.07641574130359 1.01411669962478e-67 0.915848769339863 2.1762214786399e-05 miRNAWalker2_validate -0.403260792906955 1.12713172033418e-19 25001509 Claudin 1 is a novel target of miR 375 in non small cell lung cancer; Claudin-1 CLDN1 has 4 putative miR-375 target sites in its 3'-untranslated region and this gene was determined to be a target of miR-375; CLDN1 messenger RNA and protein expression were attenuated by overexpression of miR-375 and increased by knockdown of miR-375 in NSCLC cell lines; In clinical NSCLC samples there was a negative correlation between miR-375 and CLDN1 expression r=-0.35 P=0.005; CLDN1 is a novel target of miR-375 and high miR-375 expression shortens survival in NSCLC poor survival lung squamous cell cancer hsa-miR-375 CLEC2B -3.07641574130359 1.01411669962478e-67 0.511060380189407 6.73998454287376e-05 miRanda -0.200654274514278 5.48922205887696e-14 NA NA NA hsa-miR-375 CNN3 -3.07641574130359 1.01411669962478e-67 0.445243843385684 4.64488982023214e-05 miRNAWalker2_validate;miRanda -0.129203997607295 1.95664789387387e-08 NA NA NA hsa-miR-375 CNRIP1 -3.07641574130359 1.01411669962478e-67 0.928939899013713 1.17733949512139e-12 miRanda -0.30625065778119 2.0360086139487e-30 NA NA NA hsa-let-7a-3p COL13A1 -0.885792199222571 4.41035630133324e-17 1.1104112687264 3.33843451946505e-08 miRNATAP -0.642115141862791 2.00907570261746e-16 NA NA NA hsa-let-7b-3p COL13A1 -0.506893427781244 8.27914591468333e-08 1.1104112687264 3.33843451946505e-08 miRNATAP -0.601890339853006 2.08808507143849e-11 NA NA NA hsa-miR-30d-5p COL13A1 -0.804765144490435 1.42480384315577e-16 1.1104112687264 3.33843451946505e-08 miRNATAP -0.557558717673108 7.7718977219e-11 NA NA NA hsa-miR-590-5p COL13A1 -0.778106902153173 1.13576371947651e-09 1.1104112687264 3.33843451946505e-08 miRanda -0.248869892567316 0.000198473447132603 NA NA NA hsa-miR-96-5p COL13A1 -2.57339472553563 5.77311209747623e-53 1.1104112687264 3.33843451946505e-08 TargetScan -0.429452388973643 1.27266217831174e-21 NA NA NA hsa-let-7a-5p COL4A6 -0.810823676990507 1.01381033479519e-26 2.35276111385287 6.46945942327113e-25 TargetScan -1.31793732963489 1.23552773704965e-26 NA NA NA hsa-miR-197-3p COL4A6 -0.949753058740866 6.25249252362886e-21 2.35276111385287 6.46945942327113e-25 miRNAWalker2_validate -0.939211894566256 9.42722437131539e-24 NA NA NA hsa-miR-217 COL4A6 -0.647926571365963 0.000615546232893747 2.35276111385287 6.46945942327113e-25 miRanda -0.270910351019822 3.69311467758558e-07 NA NA NA hsa-miR-29b-3p COL4A6 -0.305845215326375 0.00477759838414869 2.35276111385287 6.46945942327113e-25 miRNATAP -0.336312102772631 0.000350835988883619 NA NA NA hsa-miR-342-3p COL4A6 -1.25856075011434 9.5039654565453e-34 2.35276111385287 6.46945942327113e-25 miRanda -0.525057748629449 9.18557245892869e-09 NA NA NA hsa-miR-590-3p COL4A6 -0.58484153433625 1.6489232844135e-06 2.35276111385287 6.46945942327113e-25 miRanda -0.578292428895505 1.39725446627473e-12 NA NA NA hsa-miR-96-5p COL4A6 -2.57339472553563 5.77311209747623e-53 2.35276111385287 6.46945942327113e-25 TargetScan -0.786697114060354 1.12138889233255e-57 NA NA NA hsa-miR-375 COL8A1 -3.07641574130359 1.01411669962478e-67 -0.131485830224484 0.542362770836174 miRanda -0.197434965887037 1.36004475122601e-05 NA NA NA hsa-miR-133b COL9A2 1.6405074687617 4.27792135252442e-19 -1.33611079683919 6.76943045489084e-07 miRanda -0.279826157221174 4.03964146220426e-06 NA NA NA hsa-miR-375 CORO1C -3.07641574130359 1.01411669962478e-67 0.909383637559769 2.44762916889286e-23 miRNAWalker2_validate -0.285230863941803 1.04594829497405e-55 NA NA NA hsa-miR-375 CPEB1 -3.07641574130359 1.01411669962478e-67 2.02376070333539 1.1310793297449e-18 miRanda -0.612239209243361 2.52539491124916e-39 NA NA NA hsa-let-7a-5p CPM -0.810823676990507 1.01381033479519e-26 0.431262576427064 0.0579943478304877 MirTarget;TargetScan;miRNATAP -0.565189742731829 3.90029775400714e-06 NA NA NA hsa-let-7b-5p CPM -0.221439854958536 0.00904814983284487 0.431262576427064 0.0579943478304877 MirTarget;miRNATAP -0.302794076751144 0.00863312671756123 NA NA NA hsa-let-7d-5p CPM -0.767545769968654 1.765411565791e-19 0.431262576427064 0.0579943478304877 MirTarget;miRNATAP -0.734576134103869 1.75608271490102e-11 NA NA NA hsa-let-7e-5p CPM -0.43840772282889 6.33224012337383e-08 0.431262576427064 0.0579943478304877 MirTarget;miRNATAP -0.296282098828934 0.013247501551961 NA NA NA hsa-let-7g-5p CPM -0.614367845078204 1.65972787509666e-17 0.431262576427064 0.0579943478304877 MirTarget;miRNATAP -0.561878400177399 1.9091112935638e-05 NA NA NA hsa-miR-16-2-3p CPM -0.615426607127207 4.13943192730969e-05 0.431262576427064 0.0579943478304877 mirMAP -0.233477318166936 0.000375545465453351 NA NA NA hsa-miR-196b-5p CPM -0.805107318355036 4.71253050668845e-11 0.431262576427064 0.0579943478304877 miRNATAP -0.353279511703425 5.36515073742156e-06 NA NA NA hsa-miR-26b-5p CPM -0.737437044119268 6.43607077094955e-18 0.431262576427064 0.0579943478304877 miRNAWalker2_validate -0.558801211295971 3.70528281400123e-07 NA NA NA hsa-miR-29a-5p CPM -0.458517912323331 0.000412683536074951 0.431262576427064 0.0579943478304877 mirMAP -0.32697921419441 1.05286305126116e-05 NA NA NA hsa-miR-29b-2-5p CPM -0.789021480062028 2.59438538341121e-14 0.431262576427064 0.0579943478304877 mirMAP -0.369000614190977 5.50166987012445e-05 NA NA NA hsa-miR-29b-3p CPM -0.305845215326375 0.00477759838414869 0.431262576427064 0.0579943478304877 MirTarget -0.404672899566082 5.73719651715811e-06 NA NA NA hsa-miR-3127-5p CPM -0.584598147596649 3.00414598443422e-05 0.431262576427064 0.0579943478304877 mirMAP -0.208665717834824 0.00296105414589906 NA NA NA hsa-miR-335-3p CPM -0.625191833097363 1.64208673352814e-06 0.431262576427064 0.0579943478304877 mirMAP -0.37207777490413 3.84535167974668e-07 NA NA NA hsa-miR-33a-3p CPM -0.612459021907227 0.000347410219059134 0.431262576427064 0.0579943478304877 mirMAP -0.187144493876981 0.00117625586131276 NA NA NA hsa-miR-340-3p CPM -0.603270823477056 2.10279992453018e-08 0.431262576427064 0.0579943478304877 MirTarget -0.346562039777196 0.000100277548009402 NA NA NA hsa-miR-3607-3p CPM -1.16606393006353 2.28951370382029e-07 0.431262576427064 0.0579943478304877 mirMAP -0.207377399292208 9.14987567040096e-07 NA NA NA hsa-miR-3913-5p CPM -0.36017362814041 0.00428147059781048 0.431262576427064 0.0579943478304877 mirMAP -0.323220719998647 2.72331781503018e-05 NA NA NA hsa-miR-664a-3p CPM -0.771665734879283 3.09460128204882e-14 0.431262576427064 0.0579943478304877 mirMAP -0.460040386466413 7.46759540840178e-07 NA NA NA hsa-miR-7-1-3p CPM -1.45703750327525 1.75378847810364e-30 0.431262576427064 0.0579943478304877 mirMAP -0.432238602608135 1.40154016456929e-09 NA NA NA hsa-miR-375 CPNE8 -3.07641574130359 1.01411669962478e-67 0.724011192276426 1.89901115806229e-07 miRanda;miRNATAP -0.24572436380513 1.702920929192e-17 NA NA NA hsa-miR-375 CPPED1 -3.07641574130359 1.01411669962478e-67 0.492346858188713 2.03287569605354e-08 miRNATAP -0.122335549140637 3.62125429343455e-11 NA NA NA hsa-miR-375 CRABP2 -3.07641574130359 1.01411669962478e-67 2.00645039195079 9.80411255066333e-20 miRNAWalker2_validate -0.590494404658336 2.32265131144343e-39 NA NA NA hsa-miR-375 CRIM1 -3.07641574130359 1.01411669962478e-67 0.647632538795565 2.40803831737387e-09 miRNAWalker2_validate -0.21608495020313 5.25383107576543e-22 NA NA NA hsa-miR-375 CRYBG3 -3.07641574130359 1.01411669962478e-67 0.565487999232191 7.28279551638509e-06 miRNATAP -0.145401383919193 4.62167691903577e-08 NA NA NA hsa-miR-375 CTDSP2 -3.07641574130359 1.01411669962478e-67 0.237913070036783 0.000158688216848667 miRNAWalker2_validate -0.105296615362047 5.75667274091662e-16 NA NA NA hsa-miR-375 CTGF -3.07641574130359 1.01411669962478e-67 0.371076816789811 0.0673837358831637 miRNAWalker2_validate;miRanda -0.243570804874099 9.56866625678875e-09 NA NA NA hsa-miR-375 CTNNA2 -3.07641574130359 1.01411669962478e-67 0.515923432969918 0.10921340905539 miRanda -0.358361621143013 1.11632808802105e-07 NA NA NA hsa-miR-375 CTSC -3.07641574130359 1.01411669962478e-67 0.0992442727552616 0.391594980550986 miRNAWalker2_validate -0.18285909127879 2.05545090874763e-14 NA NA NA hsa-miR-375 CX3CR1 -3.07641574130359 1.01411669962478e-67 0.89989167544337 7.8539795877171e-07 miRanda -0.315330977114581 8.11753590831628e-17 NA NA NA hsa-miR-375 CXCL12 -3.07641574130359 1.01411669962478e-67 0.78448558178282 4.32512732617702e-07 PITA;miRanda -0.243477194857688 6.26800489421599e-14 NA NA NA hsa-miR-375 CXCL6 -3.07641574130359 1.01411669962478e-67 1.52447095461926 2.08775747832468e-09 miRanda -0.521658062522072 2.68841191461481e-23 NA NA NA hsa-miR-375 CYBB -3.07641574130359 1.01411669962478e-67 0.138456550678943 0.39968383582954 miRanda -0.177263409039057 2.67006930794424e-07 NA NA NA hsa-let-7g-3p CYP4B1 0.204677128045481 0.269606689179278 2.76506829776936 4.57951861159615e-20 MirTarget -0.206667423958082 0.00408324756468999 NA NA NA hsa-miR-324-5p CYP4B1 -0.539970285576229 1.69955273262756e-05 2.76506829776936 4.57951861159615e-20 miRanda -0.319190123051559 0.00253225310149853 NA NA NA hsa-miR-362-3p CYP4B1 -0.332355427232084 0.0356765384646951 2.76506829776936 4.57951861159615e-20 miRanda -0.180950496190509 0.0343537208668894 NA NA NA hsa-miR-653-5p CYP4B1 -0.946678912245984 1.42450392795994e-08 2.76506829776936 4.57951861159615e-20 MirTarget -0.449305168763577 1.37056544673166e-08 NA NA NA hsa-miR-375 CYP7B1 -3.07641574130359 1.01411669962478e-67 0.518581288159412 0.000200683408750114 miRanda -0.149734145723988 3.53863326573668e-07 NA NA NA hsa-miR-375 CYS1 -3.07641574130359 1.01411669962478e-67 0.877947963084651 6.65304659717736e-09 miRanda -0.312968125786328 9.01914402873587e-24 NA NA NA hsa-miR-375 CYTL1 -3.07641574130359 1.01411669962478e-67 1.21557426413984 7.06274092779591e-10 miRanda -0.341399424589182 1.2535574841868e-16 NA NA NA hsa-miR-375 DCHS2 -3.07641574130359 1.01411669962478e-67 2.06063793481642 2.27858688048227e-18 miRanda -0.734659772655905 1.06412078094851e-56 NA NA NA hsa-miR-375 DCUN1D4 -3.07641574130359 1.01411669962478e-67 0.550118929401208 5.30162028777389e-26 miRNAWalker2_validate;miRanda -0.145403376669476 2.10641926583986e-42 NA NA NA hsa-miR-375 DFNA5 -3.07641574130359 1.01411669962478e-67 0.874464190469744 2.86510709804793e-13 miRanda -0.333890273591596 1.31044093960331e-44 NA NA NA hsa-miR-375 DGKH -3.07641574130359 1.01411669962478e-67 0.904410508075172 5.32307025788734e-11 PITA;miRanda -0.249190633296226 5.06490555539899e-18 NA NA NA hsa-miR-375 DIO2 -3.07641574130359 1.01411669962478e-67 -0.210108321595055 0.176997151831277 mirMAP -0.134439561183011 4.09029191914599e-05 NA NA NA hsa-miR-375 DIP2C -3.07641574130359 1.01411669962478e-67 0.444917105830343 2.53576806009685e-11 miRNAWalker2_validate;miRanda;miRNATAP -0.117857409041073 2.69129510623423e-17 NA NA NA hsa-miR-375 DIRAS3 -3.07641574130359 1.01411669962478e-67 0.933097589737985 1.10470274402339e-09 miRanda -0.326658826932647 2.84185645998876e-25 NA NA NA hsa-let-7a-3p DKK3 -0.885792199222571 4.41035630133324e-17 1.26900808206682 1.4937507309308e-17 MirTarget;miRNATAP -0.592443710303282 1.50928223387055e-24 NA NA NA hsa-let-7a-5p DKK3 -0.810823676990507 1.01381033479519e-26 1.26900808206682 1.4937507309308e-17 TargetScan;miRNATAP -0.847115815306628 1.08103008001294e-26 NA NA NA hsa-let-7b-3p DKK3 -0.506893427781244 8.27914591468333e-08 1.26900808206682 1.4937507309308e-17 MirTarget;miRNATAP -0.526241610047692 5.07929851777539e-15 NA NA NA hsa-let-7b-5p DKK3 -0.221439854958536 0.00904814983284487 1.26900808206682 1.4937507309308e-17 miRNATAP -0.377678271594173 9.92937388400805e-07 NA NA NA hsa-let-7d-5p DKK3 -0.767545769968654 1.765411565791e-19 1.26900808206682 1.4937507309308e-17 miRNATAP -0.464813177343989 3.16116142897406e-10 NA NA NA hsa-let-7f-5p DKK3 -0.832261132545632 1.30765336262194e-16 1.26900808206682 1.4937507309308e-17 miRNATAP -0.281912523232663 8.13363332406983e-06 NA NA NA hsa-let-7g-5p DKK3 -0.614367845078204 1.65972787509666e-17 1.26900808206682 1.4937507309308e-17 miRNATAP -0.563576645054338 1.34121376297358e-10 NA NA NA hsa-miR-140-5p DKK3 -0.714046975295031 8.18104415848501e-20 1.26900808206682 1.4937507309308e-17 miRanda -0.193175070292715 0.0178042167605235 NA NA NA hsa-miR-1976 DKK3 -0.835612747570637 1.8316209115412e-14 1.26900808206682 1.4937507309308e-17 MirTarget -0.453458003273897 2.64400214222031e-15 NA NA NA hsa-miR-19a-3p DKK3 -1.31708679186777 4.80964007387792e-14 1.26900808206682 1.4937507309308e-17 miRNATAP -0.240045676023703 2.48652407521037e-11 NA NA NA hsa-miR-19b-3p DKK3 -1.59390221063917 1.21812878827867e-26 1.26900808206682 1.4937507309308e-17 miRNATAP -0.354017379434021 2.3942124599765e-18 NA NA NA hsa-miR-25-3p DKK3 -1.48824362562015 5.9514552944435e-55 1.26900808206682 1.4937507309308e-17 MirTarget -0.644504569681792 1.08607740946103e-27 NA NA NA hsa-miR-32-5p DKK3 -0.919129456898536 9.58217908367915e-12 1.26900808206682 1.4937507309308e-17 MirTarget -0.491771774051754 2.30465965207387e-27 NA NA NA hsa-miR-342-3p DKK3 -1.25856075011434 9.5039654565453e-34 1.26900808206682 1.4937507309308e-17 miRanda -0.218374972223021 0.000225573203891689 NA NA NA hsa-miR-363-3p DKK3 -1.00269053441578 1.08997020195393e-10 1.26900808206682 1.4937507309308e-17 MirTarget -0.244935335201878 2.15848137939622e-09 NA NA NA hsa-miR-491-5p DKK3 -0.996821208926168 6.43686029153545e-11 1.26900808206682 1.4937507309308e-17 miRanda -0.210895917023031 5.3393462067335e-07 NA NA NA hsa-miR-7-1-3p DKK3 -1.45703750327525 1.75378847810364e-30 1.26900808206682 1.4937507309308e-17 mirMAP -0.501246704286733 3.97731136004897e-27 NA NA NA hsa-miR-708-5p DKK3 -1.92595740173581 2.59035129879776e-32 1.26900808206682 1.4937507309308e-17 miRNATAP -0.204764986452758 4.83471380275951e-08 NA NA NA hsa-miR-92a-3p DKK3 -1.46190744133 3.47140194919109e-41 1.26900808206682 1.4937507309308e-17 MirTarget -0.651516390540946 1.20802444030415e-35 23908691 One of the roles of intracellular and extracellular miR-92a was shown to be down-regulation of Dickkopf-3 Dkk-3 a presumed tumor suppressor gene; Within the colon cancer cells suppression of Dkk-3 by miR-92a contributed to the cell proliferation; Extracellular miR-92a packed within MVs secreted by colon cancer cells was delivered into endothelial cells and contributed to the proliferation and motility of these cells through down-regulation of the same target gene Dkk-3 motility colorectal cancer hsa-miR-375 DLG4 -3.07641574130359 1.01411669962478e-67 0.92447234789153 3.01931391954291e-14 miRNAWalker2_validate -0.272428054460007 1.96021630121392e-27 NA NA NA hsa-miR-375 DMD -3.07641574130359 1.01411669962478e-67 1.66735175156547 6.32578133694449e-20 miRanda -0.519903670683368 1.9637682974884e-45 NA NA NA hsa-miR-375 DNAH11 -3.07641574130359 1.01411669962478e-67 0.973577459070637 4.1113267290659e-05 miRNAWalker2_validate -0.351278193815331 1.40559826969738e-12 NA NA NA hsa-miR-375 DOCK5 -3.07641574130359 1.01411669962478e-67 0.52853727784185 0.000142957656523633 miRanda -0.168287196787976 8.36637928657593e-09 NA NA NA hsa-miR-375 DOK7 -3.07641574130359 1.01411669962478e-67 0.988991386825175 3.45890849955297e-07 miRNAWalker2_validate -0.340716017093843 2.86745091953674e-17 NA NA NA hsa-miR-375 DPY19L1 -3.07641574130359 1.01411669962478e-67 0.608141092899252 1.11266546192223e-09 miRNAWalker2_validate -0.178301857196902 1.02109691069963e-17 NA NA NA hsa-miR-375 DPYSL2 -3.07641574130359 1.01411669962478e-67 0.697683017196469 3.0845471255991e-10 PITA;miRanda -0.273221268366099 2.5327036631609e-34 NA NA NA hsa-miR-375 DPYSL3 -3.07641574130359 1.01411669962478e-67 1.16449354495094 3.74691550862512e-20 miRNAWalker2_validate -0.350726234514233 1.54514144985583e-42 NA NA NA hsa-miR-375 DUSP6 -3.07641574130359 1.01411669962478e-67 0.64749276488494 5.14620822447961e-07 miRNAWalker2_validate;miRanda -0.216904292778499 6.4535257990701e-16 NA NA NA hsa-miR-375 EBF3 -3.07641574130359 1.01411669962478e-67 0.243171383708406 0.115511044888428 miRanda;miRNATAP -0.139317439757927 1.8365099315448e-05 NA NA NA hsa-miR-375 EDIL3 -3.07641574130359 1.01411669962478e-67 1.77655527651803 1.39272711870831e-09 miRanda -0.552594076356101 1.23652261956066e-19 NA NA NA hsa-miR-375 EDN3 -3.07641574130359 1.01411669962478e-67 2.29848391012859 3.44000920055872e-12 miRanda -0.512285637143594 2.31282814547662e-13 NA NA NA hsa-miR-140-5p EDNRB -0.714046975295031 8.18104415848501e-20 1.46766705007395 5.29067244228736e-14 miRanda -0.302610928085533 0.00430008094620586 NA NA NA hsa-miR-142-5p EDNRB -0.570537423718147 5.59576699766966e-05 1.46766705007395 5.29067244228736e-14 mirMAP -0.131033590718911 0.0289862826335654 NA NA NA hsa-miR-146b-5p EDNRB -1.70281490248323 9.08060943822522e-35 1.46766705007395 5.29067244228736e-14 miRanda;miRNATAP -0.315698559190625 3.25709982993424e-08 NA NA NA hsa-miR-16-2-3p EDNRB -0.615426607127207 4.13943192730969e-05 1.46766705007395 5.29067244228736e-14 mirMAP -0.208316044978932 0.000301343431624818 NA NA NA hsa-miR-182-5p EDNRB -2.57717136150549 4.94377928074908e-59 1.46766705007395 5.29067244228736e-14 miRNATAP -0.551006974445749 1.18955556657319e-34 NA NA NA hsa-miR-186-5p EDNRB -0.567811924899222 1.37607142180843e-13 1.46766705007395 5.29067244228736e-14 mirMAP -0.739025534600737 7.0184570927622e-12 NA NA NA hsa-miR-195-3p EDNRB -0.598450619600341 1.01415597921415e-08 1.46766705007395 5.29067244228736e-14 mirMAP -0.296515737833831 0.000240950110391698 NA NA NA hsa-miR-199b-5p EDNRB -1.17761875205879 1.04905958983479e-17 1.46766705007395 5.29067244228736e-14 miRanda -0.141301663409604 0.0189983748073866 NA NA NA hsa-miR-30b-5p EDNRB -1.16764575603669 1.75395013539893e-20 1.46766705007395 5.29067244228736e-14 mirMAP -0.41351571791618 1.35243014737634e-10 NA NA NA hsa-miR-30c-5p EDNRB -0.746747513281496 1.32431877874928e-12 1.46766705007395 5.29067244228736e-14 mirMAP -0.300880650909207 0.00015007357819384 NA NA NA hsa-miR-30d-5p EDNRB -0.804765144490435 1.42480384315577e-16 1.46766705007395 5.29067244228736e-14 mirMAP -0.53655064171617 1.86313308097512e-10 NA NA NA hsa-miR-30e-5p EDNRB 0.0410434441382375 0.610918464525074 1.46766705007395 5.29067244228736e-14 mirMAP -0.285727814765873 0.00753600245306041 NA NA NA hsa-miR-34c-5p EDNRB -0.411316782408141 0.0146968432653683 1.46766705007395 5.29067244228736e-14 miRanda -0.185436305727548 0.000245962241883328 NA NA NA hsa-miR-361-5p EDNRB -0.652200980992921 2.23302456529972e-21 1.46766705007395 5.29067244228736e-14 miRanda -0.481878315618679 6.41521245388749e-05 NA NA NA hsa-miR-590-3p EDNRB -0.58484153433625 1.6489232844135e-06 1.46766705007395 5.29067244228736e-14 miRanda;mirMAP -0.376249920660858 4.64548275464571e-08 NA NA NA hsa-miR-590-5p EDNRB -0.778106902153173 1.13576371947651e-09 1.46766705007395 5.29067244228736e-14 miRanda -0.364653504705956 2.15787110124939e-08 NA NA NA hsa-miR-7-1-3p EDNRB -1.45703750327525 1.75378847810364e-30 1.46766705007395 5.29067244228736e-14 mirMAP -0.623131719246026 1.17238419478427e-24 NA NA NA hsa-miR-96-5p EDNRB -2.57339472553563 5.77311209747623e-53 1.46766705007395 5.29067244228736e-14 miRNATAP -0.523123125574811 5.46910604627502e-34 NA NA NA hsa-miR-375 EFNB3 -3.07641574130359 1.01411669962478e-67 0.964640717530167 2.20014811285709e-07 miRanda -0.204875279397677 2.10592343152736e-07 NA NA NA hsa-miR-142-3p EFS -0.668342567225765 0.000202408167795488 1.51890508361349 4.23543770062039e-16 miRanda -0.1700411210037 0.000169541058556185 NA NA NA hsa-miR-146b-5p EFS -1.70281490248323 9.08060943822522e-35 1.51890508361349 4.23543770062039e-16 miRanda -0.243101607882815 1.06780633738997e-05 NA NA NA hsa-miR-320a EFS -0.995486653328464 1.19389676663012e-20 1.51890508361349 4.23543770062039e-16 PITA;miRanda;miRNATAP -0.154267848356209 0.0379304913481057 NA NA NA hsa-miR-491-5p EFS -0.996821208926168 6.43686029153545e-11 1.51890508361349 4.23543770062039e-16 miRanda -0.223629256023225 2.30494896538172e-05 NA NA NA hsa-miR-375 EGFR -3.07641574130359 1.01411669962478e-67 0.875530319621402 3.38868940339054e-08 miRanda -0.23444110680797 2.03977396004287e-12 NA NA NA hsa-miR-375 EIF4EBP2 -3.07641574130359 1.01411669962478e-67 0.602305869989245 2.10443655850806e-27 miRNAWalker2_validate -0.171350080088682 2.09941787732344e-53 NA NA NA hsa-miR-375 ELAVL3 -3.07641574130359 1.01411669962478e-67 1.90123667741662 1.68128264797035e-12 miRNATAP -0.3521179792422 8.81505770293922e-10 NA NA NA hsa-miR-375 EMP1 -3.07641574130359 1.01411669962478e-67 0.259566543924802 0.100302467571549 miRNAWalker2_validate -0.145467951784246 1.20573787128484e-05 NA NA NA hsa-miR-375 ENAH -3.07641574130359 1.01411669962478e-67 0.626468877135957 5.16461166693171e-16 miRNAWalker2_validate;miRNATAP -0.181431996392184 3.36746997290818e-30 NA NA NA hsa-miR-133a-3p ENC1 0.593956710502209 0.000305971128010422 -0.544645623586936 9.60825657064375e-06 MirTarget -0.174402036823436 3.62868348795567e-08 NA NA NA hsa-miR-133b ENC1 1.6405074687617 4.27792135252442e-19 -0.544645623586936 9.60825657064375e-06 MirTarget;miRanda -0.128081883547327 3.7394584692412e-06 NA NA NA hsa-miR-145-5p ENC1 0.0645550892386915 0.583308140519148 -0.544645623586936 9.60825657064375e-06 MirTarget -0.202284524466743 6.51247438473779e-06 NA NA NA hsa-miR-149-5p ENC1 -0.653969866006385 3.97144325806485e-05 -0.544645623586936 9.60825657064375e-06 MirTarget -0.160443261164923 9.82971091588454e-07 NA NA NA hsa-miR-26b-5p ENC1 -0.737437044119268 6.43607077094955e-18 -0.544645623586936 9.60825657064375e-06 mirMAP;miRNATAP -0.122667992817095 0.0424627813083778 NA NA NA hsa-miR-27b-3p ENC1 0.671557822127916 5.00469777243463e-17 -0.544645623586936 9.60825657064375e-06 miRNATAP -0.170491618409472 0.00840410005240078 NA NA NA hsa-miR-28-3p ENC1 -0.464592918249583 2.99677077334845e-12 -0.544645623586936 9.60825657064375e-06 MirTarget;PITA;miRNATAP -0.210240804231412 0.00780830440407277 NA NA NA hsa-miR-29a-5p ENC1 -0.458517912323331 0.000412683536074951 -0.544645623586936 9.60825657064375e-06 mirMAP -0.134759536231677 0.000894331168399306 NA NA NA hsa-miR-3065-5p ENC1 -1.04645334963496 3.19942342920484e-08 -0.544645623586936 9.60825657064375e-06 mirMAP -0.119357142690619 1.79139736870041e-05 NA NA NA hsa-miR-30b-5p ENC1 -1.16764575603669 1.75395013539893e-20 -0.544645623586936 9.60825657064375e-06 mirMAP -0.140336149930533 0.000524628847313469 NA NA NA hsa-miR-30c-5p ENC1 -0.746747513281496 1.32431877874928e-12 -0.544645623586936 9.60825657064375e-06 mirMAP -0.225940255691084 4.11752148604594e-06 NA NA NA hsa-miR-339-5p ENC1 -0.986556478524229 2.39294233177812e-12 -0.544645623586936 9.60825657064375e-06 MirTarget;miRanda -0.112979351483041 0.00214143179495869 NA NA NA hsa-miR-532-5p ENC1 -0.819279743754759 7.8621216315329e-15 -0.544645623586936 9.60825657064375e-06 PITA -0.112391899706058 0.0221486480025392 NA NA NA hsa-miR-375 ERC1 -3.07641574130359 1.01411669962478e-67 0.63473141703119 3.03350660236168e-16 miRNATAP -0.176483092002696 3.88715893432207e-28 NA NA NA hsa-miR-375 ESPNL -3.07641574130359 1.01411669962478e-67 1.40196433972483 4.26995359173324e-09 miRNAWalker2_validate -0.506355864529498 5.0152373789052e-25 NA NA NA hsa-miR-375 EXT1 -3.07641574130359 1.01411669962478e-67 0.42883177261709 1.22201436868235e-11 miRNAWalker2_validate -0.141363642225586 9.0660184932031e-28 NA NA NA hsa-miR-182-5p FAM107A -2.57717136150549 4.94377928074908e-59 1.81522598889693 2.71095982092692e-23 MirTarget -0.569088515902203 2.19201411168439e-41 NA NA NA hsa-miR-186-5p FAM107A -0.567811924899222 1.37607142180843e-13 1.81522598889693 2.71095982092692e-23 mirMAP -0.618648609173761 2.12647968238222e-09 NA NA NA hsa-miR-30d-3p FAM107A -0.917692758870647 7.72239658481192e-16 1.81522598889693 2.71095982092692e-23 mirMAP -0.517746849893141 2.90890843857237e-14 NA NA NA hsa-miR-342-3p FAM107A -1.25856075011434 9.5039654565453e-34 1.81522598889693 2.71095982092692e-23 miRanda -0.32169482088574 1.14369401839394e-05 NA NA NA hsa-miR-491-5p FAM107A -0.996821208926168 6.43686029153545e-11 1.81522598889693 2.71095982092692e-23 miRanda -0.234375893665827 7.54680526935092e-06 NA NA NA hsa-miR-590-5p FAM107A -0.778106902153173 1.13576371947651e-09 1.81522598889693 2.71095982092692e-23 miRanda -0.386538178976669 4.26758250723466e-10 NA NA NA hsa-miR-708-5p FAM107A -1.92595740173581 2.59035129879776e-32 1.81522598889693 2.71095982092692e-23 MirTarget -0.441633736495784 1.58429911458279e-22 NA NA NA hsa-miR-769-5p FAM107A -0.496725395031541 5.04386163179333e-07 1.81522598889693 2.71095982092692e-23 MirTarget -0.523729981769469 8.19863483220765e-11 NA NA NA hsa-miR-375 FAM153A -3.07641574130359 1.01411669962478e-67 0.389093389753511 0.0261129786800567 miRanda -0.186075155023605 4.09374817648598e-07 NA NA NA hsa-miR-375 FAM153B -3.07641574130359 1.01411669962478e-67 0.317866796752321 0.0883053142862621 miRanda -0.13397803304574 0.000671257386930179 NA NA NA hsa-miR-375 FAM155A -3.07641574130359 1.01411669962478e-67 1.03043619289297 5.62661779949995e-06 miRanda -0.274263050958939 1.0087263768495e-08 NA NA NA hsa-miR-375 FAM167A -3.07641574130359 1.01411669962478e-67 1.93301473710099 5.20746400905308e-18 mirMAP -0.579981125342943 4.74571526260359e-37 NA NA NA hsa-miR-375 FAM63B -3.07641574130359 1.01411669962478e-67 0.615495210459521 0.000112112247011972 miRNAWalker2_validate -0.1362504901109 5.45195828838863e-05 NA NA NA hsa-miR-375 FAM89A -3.07641574130359 1.01411669962478e-67 0.58056552054749 7.79191277213685e-08 miRNAWalker2_validate -0.203835390764159 7.33213305392635e-20 NA NA NA hsa-miR-149-5p FBLN1 -0.653969866006385 3.97144325806485e-05 0.772924257028068 4.40016629219698e-06 MirTarget -0.118605405033866 0.00874720320210572 NA NA NA hsa-miR-429 FBLN1 -0.682420529994949 0.00462213397220848 0.772924257028068 4.40016629219698e-06 miRanda -0.115078615583215 0.00011662571358237 NA NA NA hsa-miR-491-5p FBLN1 -0.996821208926168 6.43686029153545e-11 0.772924257028068 4.40016629219698e-06 miRanda -0.187670141457396 5.81707529089512e-05 NA NA NA hsa-miR-375 FBN1 -3.07641574130359 1.01411669962478e-67 0.619158584924654 5.60341698781822e-05 mirMAP -0.312785870333937 2.12644055606828e-23 NA NA NA hsa-miR-375 FBN2 -3.07641574130359 1.01411669962478e-67 1.04293627537831 2.67587121247825e-06 miRanda -0.280082215114748 2.21253985136778e-09 NA NA NA hsa-miR-375 FBXL21 -3.07641574130359 1.01411669962478e-67 2.39174639359667 7.85412582420884e-14 miRanda -0.418965273611998 9.34192780289963e-10 NA NA NA hsa-miR-375 FER -3.07641574130359 1.01411669962478e-67 0.961893337547546 2.29220807778061e-12 miRanda -0.286634404565336 5.60921000103289e-24 NA NA NA hsa-miR-375 FHAD1 -3.07641574130359 1.01411669962478e-67 0.925740906642887 3.75929105336654e-06 miRanda -0.318530149140026 2.35994559563702e-14 NA NA NA hsa-miR-375 FHL5 -3.07641574130359 1.01411669962478e-67 1.13584540050279 1.65855843603496e-08 miRanda -0.346371219995179 1.57812912624907e-16 NA NA NA hsa-miR-375 FILIP1 -3.07641574130359 1.01411669962478e-67 1.81544083673708 3.62906073051047e-17 miRanda -0.537367764031183 4.56926963432277e-34 NA NA NA hsa-miR-375 FKBP1B -3.07641574130359 1.01411669962478e-67 0.178612650658674 0.381496480609174 miRNAWalker2_validate -0.118712414239287 0.00593859974882384 NA NA NA hsa-let-7a-3p FLRT3 -0.885792199222571 4.41035630133324e-17 1.84370819822501 3.47278465286523e-13 mirMAP -0.715158099396252 9.59730265066104e-13 NA NA NA hsa-let-7b-3p FLRT3 -0.506893427781244 8.27914591468333e-08 1.84370819822501 3.47278465286523e-13 mirMAP -0.476782660047603 3.87977624279752e-05 NA NA NA hsa-let-7f-1-3p FLRT3 -0.159920578752557 0.190200799823397 1.84370819822501 3.47278465286523e-13 mirMAP -0.206667348452658 0.0244678895316137 NA NA NA hsa-let-7g-3p FLRT3 0.204677128045481 0.269606689179278 1.84370819822501 3.47278465286523e-13 MirTarget;miRNATAP -0.142238707627968 0.0172630734669621 NA NA NA hsa-miR-130b-5p FLRT3 -1.15237450600836 1.6187151436434e-14 1.84370819822501 3.47278465286523e-13 miRNATAP -0.613125985636524 1.36289088616034e-18 NA NA NA hsa-miR-148a-5p FLRT3 -1.02522933532111 6.47121686767e-19 1.84370819822501 3.47278465286523e-13 MirTarget;miRNATAP -0.678903727612572 8.12616220509399e-14 NA NA NA hsa-miR-16-1-3p FLRT3 -0.6666012357419 1.3217954391766e-06 1.84370819822501 3.47278465286523e-13 mirMAP -0.210360565394335 0.00887342642453649 NA NA NA hsa-miR-16-2-3p FLRT3 -0.615426607127207 4.13943192730969e-05 1.84370819822501 3.47278465286523e-13 mirMAP -0.359941993441516 1.32412217130958e-06 NA NA NA hsa-miR-183-5p FLRT3 -2.41864571314465 9.99562656802565e-54 1.84370819822501 3.47278465286523e-13 miRNATAP -0.576196312857085 6.24402283168673e-21 NA NA NA hsa-miR-193b-3p FLRT3 -0.425830265253153 0.00142308830221877 1.84370819822501 3.47278465286523e-13 MirTarget;miRNATAP -0.279935183474125 0.000700983371925125 NA NA NA hsa-miR-199a-5p FLRT3 -0.56859326149571 4.98517644263078e-07 1.84370819822501 3.47278465286523e-13 MirTarget;PITA;miRanda;miRNATAP -0.325354496542195 0.000796005148950014 NA NA NA hsa-miR-199b-5p FLRT3 -1.17761875205879 1.04905958983479e-17 1.84370819822501 3.47278465286523e-13 MirTarget;PITA;miRanda;miRNATAP -0.28967235758988 0.000198859047022319 NA NA NA hsa-miR-19b-1-5p FLRT3 -1.2422681534557 6.28223951411771e-20 1.84370819822501 3.47278465286523e-13 MirTarget -0.644167928274569 3.29903340564895e-17 NA NA NA hsa-miR-3065-5p FLRT3 -1.04645334963496 3.19942342920484e-08 1.84370819822501 3.47278465286523e-13 miRNATAP -0.2994343432474 2.4367303595421e-07 NA NA NA hsa-miR-335-3p FLRT3 -0.625191833097363 1.64208673352814e-06 1.84370819822501 3.47278465286523e-13 MirTarget;mirMAP -0.222587121261021 0.00822903815000913 NA NA NA hsa-miR-33a-3p FLRT3 -0.612459021907227 0.000347410219059134 1.84370819822501 3.47278465286523e-13 mirMAP -0.388893114682849 2.1466584082198e-09 NA NA NA hsa-miR-340-5p FLRT3 -0.418767158937088 8.44911569437027e-06 1.84370819822501 3.47278465286523e-13 mirMAP -0.365200817441839 0.00186618053600667 NA NA NA hsa-miR-342-3p FLRT3 -1.25856075011434 9.5039654565453e-34 1.84370819822501 3.47278465286523e-13 miRanda -0.399725832841875 6.26573103141433e-05 NA NA NA hsa-miR-375 FLRT3 -3.07641574130359 1.01411669962478e-67 1.84370819822501 3.47278465286523e-13 PITA;miRanda -0.555028600131137 2.82363854299629e-26 NA NA NA hsa-miR-450b-5p FLRT3 0.857642158166269 2.78318878314148e-06 1.84370819822501 3.47278465286523e-13 MirTarget;PITA;mirMAP;miRNATAP -0.255538219884559 1.84458584530847e-05 NA NA NA hsa-miR-542-3p FLRT3 0.31864941892079 0.0301489241026756 1.84370819822501 3.47278465286523e-13 MirTarget;PITA;miRanda;miRNATAP -0.474008919107877 1.62816578951613e-10 NA NA NA hsa-miR-584-5p FLRT3 -0.52935374047527 5.69276295507765e-06 1.84370819822501 3.47278465286523e-13 MirTarget -0.566988869057987 1.13113942816396e-09 NA NA NA hsa-miR-590-3p FLRT3 -0.58484153433625 1.6489232844135e-06 1.84370819822501 3.47278465286523e-13 PITA;miRanda;mirMAP;miRNATAP -0.530410884267187 2.63900605875396e-09 NA NA NA hsa-miR-590-5p FLRT3 -0.778106902153173 1.13576371947651e-09 1.84370819822501 3.47278465286523e-13 miRanda -0.638420430040073 2.02539246868254e-14 NA NA NA hsa-miR-653-5p FLRT3 -0.946678912245984 1.42450392795994e-08 1.84370819822501 3.47278465286523e-13 MirTarget -0.41388907131708 2.44829889512565e-10 NA NA NA hsa-miR-655-3p FLRT3 -0.547567790590951 0.000167355770742551 1.84370819822501 3.47278465286523e-13 MirTarget -0.300250901167404 8.9012833683008e-05 NA NA NA hsa-miR-758-3p FLRT3 0.211869319654926 0.0914171241118064 1.84370819822501 3.47278465286523e-13 MirTarget -0.188063567223804 0.0340839062262233 NA NA NA hsa-miR-375 FOLR1 -3.07641574130359 1.01411669962478e-67 2.65115842479626 1.30709034743873e-16 miRNAWalker2_validate -0.777126070561432 3.92415492991751e-32 NA NA NA hsa-miR-375 FOXC1 -3.07641574130359 1.01411669962478e-67 0.644626047541315 7.75201044073532e-07 miRanda -0.262451397894426 1.08693693862406e-22 NA NA NA hsa-miR-30a-5p FOXD1 -0.508562243919922 3.02321261664392e-06 -3.38864859664511 2.72784969127102e-18 miRNAWalker2_validate;MirTarget;miRNATAP -0.390445541522504 0.0127374125594042 NA NA NA hsa-miR-30e-5p FOXD1 0.0410434441382375 0.610918464525074 -3.38864859664511 2.72784969127102e-18 MirTarget -0.51167393859493 0.0173454528671969 NA NA NA hsa-miR-375 FOXF1 -3.07641574130359 1.01411669962478e-67 1.02246249778188 1.45254781946893e-09 miRanda -0.320416049254422 6.74208788093601e-20 NA NA NA hsa-miR-375 FOXP2 -3.07641574130359 1.01411669962478e-67 1.85692656502198 3.25138326051447e-13 miRanda -0.542817959853455 8.79550660579054e-25 NA NA NA hsa-miR-106a-5p FOXQ1 -1.76751200862602 7.79031604495387e-24 1.72636179718979 4.90517560943518e-15 MirTarget -0.310387953541099 2.31350243549411e-09 NA NA NA hsa-miR-106b-5p FOXQ1 -1.03194006819592 5.97693261279532e-24 1.72636179718979 4.90517560943518e-15 MirTarget -0.627795267986502 1.81157535211856e-12 NA NA NA hsa-miR-128-3p FOXQ1 -0.314011160241606 0.000267378314657252 1.72636179718979 4.90517560943518e-15 MirTarget -0.582399978810881 1.77726788165129e-07 NA NA NA hsa-miR-140-3p FOXQ1 -0.589055604093291 1.70551761364582e-15 1.72636179718979 4.90517560943518e-15 MirTarget -0.325675172644716 0.011351001361127 NA NA NA hsa-miR-17-5p FOXQ1 -1.75236465070226 3.95158641627966e-36 1.72636179718979 4.90517560943518e-15 MirTarget;TargetScan -0.542267949826347 5.33264608199651e-18 NA NA NA hsa-miR-20a-5p FOXQ1 -1.8613782696103 3.92351368893149e-34 1.72636179718979 4.90517560943518e-15 MirTarget -0.454970024069955 3.63885540606548e-15 NA NA NA hsa-miR-20b-5p FOXQ1 -1.58314196476133 5.61327965534576e-17 1.72636179718979 4.90517560943518e-15 MirTarget -0.315008915562578 1.0557807541572e-10 NA NA NA hsa-miR-342-3p FOXQ1 -1.25856075011434 9.5039654565453e-34 1.72636179718979 4.90517560943518e-15 miRanda;miRNATAP -0.331888425525274 0.00014297697737436 27162244 FOXM1 and FOXQ1 Are Promising Prognostic Biomarkers and Novel Targets of Tumor Suppressive miR 342 in Human Colorectal Cancer; Furthermore using bioinformatic approaches we identified miR-342 as a novel regulator of both FOXM1 and FOXQ1; Collectively we have firstly identified FOXM1 and FOXQ1 as promising prognostic biomarkers in colorectal cancer patients and provided novel evidence that therapeutic targeting of these genes or miR-342 may be a potential treatment approach in colorectal cancer patients colorectal cancer hsa-miR-3607-3p FOXQ1 -1.16606393006353 2.28951370382029e-07 1.72636179718979 4.90517560943518e-15 MirTarget -0.206098175043657 9.42201022783082e-07 NA NA NA hsa-miR-590-3p FOXQ1 -0.58484153433625 1.6489232844135e-06 1.72636179718979 4.90517560943518e-15 miRanda -0.246441440763929 0.00174632005613693 NA NA NA hsa-miR-93-5p FOXQ1 -2.02673564951393 4.11722430511061e-49 1.72636179718979 4.90517560943518e-15 MirTarget -0.558690366304299 1.67283545559756e-19 NA NA NA hsa-miR-96-5p FOXQ1 -2.57339472553563 5.77311209747623e-53 1.72636179718979 4.90517560943518e-15 MirTarget;TargetScan -0.466827385329368 1.18349304286041e-20 NA NA NA hsa-miR-375 FRMD6 -3.07641574130359 1.01411669962478e-67 1.65366705532963 1.29321026291239e-27 miRanda -0.469044201529463 5.09473802920065e-53 NA NA NA hsa-miR-375 FUT8 -3.07641574130359 1.01411669962478e-67 0.309474802129166 9.53031519680209e-05 miRanda -0.150329467667706 2.36064026243693e-20 NA NA NA hsa-let-7c-5p FZD8 -0.0545238982989673 0.574033952733803 -1.38934902547281 1.41911152896003e-18 miRNAWalker2_validate -0.587765629547143 6.53593052169116e-17 NA NA NA hsa-miR-100-5p FZD8 0.231007085450551 0.0155610142898595 -1.38934902547281 1.41911152896003e-18 MirTarget -0.167133467541374 0.0228194639273199 NA NA NA hsa-miR-125a-3p FZD8 0.335450161542356 0.00400908432417963 -1.38934902547281 1.41911152896003e-18 miRanda -0.15481213641026 0.0108639845852242 NA NA NA hsa-miR-362-3p FZD8 -0.332355427232084 0.0356765384646951 -1.38934902547281 1.41911152896003e-18 miRanda -0.133119606773957 0.00282022457870742 NA NA NA hsa-miR-374b-5p FZD8 -0.221226738167835 0.00747242957932152 -1.38934902547281 1.41911152896003e-18 miRNAWalker2_validate -0.170743080718086 0.0446547605746815 NA NA NA hsa-miR-542-3p FZD8 0.31864941892079 0.0301489241026756 -1.38934902547281 1.41911152896003e-18 miRanda -0.281231524267423 1.87463521003047e-09 NA NA NA hsa-miR-99a-5p FZD8 0.152230182127974 0.171494306325442 -1.38934902547281 1.41911152896003e-18 MirTarget -0.391268473344799 2.68174729709982e-10 NA NA NA hsa-miR-375 GADD45A -3.07641574130359 1.01411669962478e-67 0.897838655056201 1.39167016195132e-13 miRanda -0.313799141768411 1.51944348449224e-37 NA NA NA hsa-miR-375 GALM -3.07641574130359 1.01411669962478e-67 0.662006996703374 6.96154474253996e-05 miRNAWalker2_validate -0.2849138127417 1.35937594495735e-16 NA NA NA hsa-miR-375 GAP43 -3.07641574130359 1.01411669962478e-67 -0.177278534796731 0.486202187312854 miRanda -0.137850148562647 0.0104675588695313 NA NA NA hsa-miR-375 GAPT -3.07641574130359 1.01411669962478e-67 0.510385993321486 0.00161607740688324 miRanda -0.234786383376374 3.3626296497537e-12 NA NA NA hsa-miR-375 GAS7 -3.07641574130359 1.01411669962478e-67 0.73693667838782 7.60615818559584e-08 mirMAP -0.342764851815162 9.02319083274199e-36 NA NA NA hsa-miR-139-5p GDPD1 0.248477989074289 0.0406493945332509 -1.11161173544561 9.45879042935833e-12 miRanda -0.317989329286889 4.19457270979142e-08 NA NA NA hsa-miR-155-5p GDPD1 -0.657127495088523 1.32358745918864e-06 -1.11161173544561 9.45879042935833e-12 MirTarget -0.145681123843685 0.00493787844548992 NA NA NA hsa-miR-24-3p GDPD1 0.460804468884131 9.35756069405521e-09 -1.11161173544561 9.45879042935833e-12 MirTarget -0.340308349687599 0.000106517891617627 NA NA NA hsa-miR-338-3p GDPD1 -0.289775600192434 0.0820821857540406 -1.11161173544561 9.45879042935833e-12 miRanda -0.129666558242601 0.00231072443161277 NA NA NA hsa-miR-338-5p GDPD1 1.0222700595457 1.2342974008659e-09 -1.11161173544561 9.45879042935833e-12 PITA -0.101015928406654 0.015916212763618 NA NA NA hsa-miR-125a-3p GLYATL1 0.335450161542356 0.00400908432417963 -2.57418778285828 7.14969577231711e-20 miRanda -0.467872583020413 1.55082377531492e-05 NA NA NA hsa-miR-27a-3p GLYATL1 0.422972805377022 8.01035506212495e-07 -2.57418778285828 7.14969577231711e-20 MirTarget -0.682269014345692 2.33164420373424e-06 NA NA NA hsa-miR-27b-3p GLYATL1 0.671557822127916 5.00469777243463e-17 -2.57418778285828 7.14969577231711e-20 MirTarget -0.809323010306938 8.70726310932174e-08 NA NA NA hsa-miR-375 GNAO1 -3.07641574130359 1.01411669962478e-67 2.18797287721579 5.13469727874141e-29 miRanda -0.684259242336895 5.64949569384781e-72 NA NA NA hsa-miR-375 GPM6B -3.07641574130359 1.01411669962478e-67 1.23060855973652 2.93607884947677e-20 miRanda -0.351510969539636 5.91978228666991e-38 NA NA NA hsa-miR-375 GPR146 -3.07641574130359 1.01411669962478e-67 0.375822162000336 6.24517031140195e-06 miRanda -0.130650234103021 4.6091248891263e-14 NA NA NA hsa-miR-375 GPR157 -3.07641574130359 1.01411669962478e-67 0.34829159835295 0.0347735228744703 miRNAWalker2_validate;mirMAP -0.124073091859518 0.000371042766215326 NA NA NA hsa-miR-140-5p GPRC5B -0.714046975295031 8.18104415848501e-20 1.76736906949133 1.16770627889328e-33 miRanda -0.395013828579529 1.48001317416973e-06 NA NA NA hsa-miR-141-3p GPRC5B -1.79566520772936 2.43414267305203e-29 1.76736906949133 1.16770627889328e-33 mirMAP -0.46538128812241 1.18744616726073e-36 NA NA NA hsa-miR-340-5p GPRC5B -0.418767158937088 8.44911569437027e-06 1.76736906949133 1.16770627889328e-33 mirMAP -0.209606396401947 0.00297674959142161 NA NA NA hsa-miR-96-5p GPRC5B -2.57339472553563 5.77311209747623e-53 1.76736906949133 1.16770627889328e-33 TargetScan -0.497426634075764 1.35443623276497e-53 NA NA NA hsa-miR-375 GRAMD1B -3.07641574130359 1.01411669962478e-67 1.27985802464945 2.06885869122789e-10 miRanda -0.436797272595153 4.50014592838234e-26 NA NA NA hsa-miR-375 GRIA2 -3.07641574130359 1.01411669962478e-67 1.33193621899581 1.65736454090896e-07 miRanda -0.412196062765029 9.10000772886597e-15 NA NA NA hsa-miR-375 GRIA3 -3.07641574130359 1.01411669962478e-67 1.59573400325763 3.63149115352607e-09 miRanda -0.492828527277955 2.03522226640996e-18 NA NA NA hsa-miR-375 GRIK2 -3.07641574130359 1.01411669962478e-67 0.918940262772085 2.96791814903145e-07 miRanda;miRNATAP -0.252911841833841 1.95592669728804e-11 NA NA NA hsa-miR-375 GRIK3 -3.07641574130359 1.01411669962478e-67 0.630148393076332 0.00211025897067168 miRanda -0.287510929757048 1.78599035456808e-11 NA NA NA hsa-miR-375 GRIK5 -3.07641574130359 1.01411669962478e-67 0.918757618933275 3.27475305288659e-10 miRNATAP -0.382803392729485 3.26080457774106e-39 NA NA NA hsa-miR-375 GTF2A1 -3.07641574130359 1.01411669962478e-67 0.759896329078714 0.000884917462104875 miRanda -0.198220141047944 4.13358283638676e-05 NA NA NA hsa-miR-375 HAS2 -3.07641574130359 1.01411669962478e-67 1.14077377258679 1.58192824154594e-07 miRNATAP -0.323612841418105 1.38609642561634e-12 NA NA NA hsa-miR-375 HAS3 -3.07641574130359 1.01411669962478e-67 1.0039940884244 4.57139228745054e-08 miRanda -0.342751655200471 2.09760072086657e-19 NA NA NA hsa-miR-375 HECTD2 -3.07641574130359 1.01411669962478e-67 0.956868108947306 3.84391190012899e-19 miRanda -0.231239673396851 5.71265858155601e-25 NA NA NA hsa-miR-375 HOXA7 -3.07641574130359 1.01411669962478e-67 1.31876439935161 3.042978543463e-17 miRanda -0.402397150810153 1.25695589591523e-36 NA NA NA hsa-miR-375 HOXB3 -3.07641574130359 1.01411669962478e-67 1.30871787967927 3.05098896622051e-12 PITA;miRanda -0.486982437012881 4.60477971261564e-38 27186281 Deregulation of MicroRNA 375 inhibits cancer proliferation migration and chemosensitivity in pancreatic cancer through the association of HOXB3; HOXB3 was also downregulated in Capan-1 and PANC-1 cells to assess its functional correlation with miR-375 on cancer regulation; HOXB3 was directly bound by miR-375 and was negatively regulated by miR-375 in pancreatic cancer cells; Subsequent HOXB3 downregulation reversed the suppression of miR-375 downregulation on cancer proliferation migration and cisplatin chemosensitivity in pancreatic cancer; Deregulation of miR-375 is inhibitory to the development of pancreatic cancer and reversely regulated by HOXB3 pancreatic cancer hsa-miR-375 HOXB9 -3.07641574130359 1.01411669962478e-67 0.325746268691463 0.177545523225866 miRanda -0.324169788598201 1.17870346113751e-10 NA NA NA hsa-miR-375 HOXC10 -3.07641574130359 1.01411669962478e-67 0.827518677556696 0.00366756677024343 miRanda -0.332097862613026 2.79861629344187e-08 NA NA NA hsa-miR-375 HOXD3 -3.07641574130359 1.01411669962478e-67 0.673347198204319 0.000979629522870031 miRanda -0.280743078361724 4.80548457210311e-11 NA NA NA hsa-miR-375 HPDL -3.07641574130359 1.01411669962478e-67 1.04289368281426 1.45006502249239e-06 miRanda -0.167101579199498 0.000290934598473008 NA NA NA hsa-miR-375 HPGDS -3.07641574130359 1.01411669962478e-67 0.633509587937268 0.00047851993557839 miRanda -0.139985507531356 0.000271593067454362 NA NA NA hsa-miR-375 HSD17B13 -3.07641574130359 1.01411669962478e-67 2.42547067339511 3.71713773762153e-12 miRanda -0.427469218108585 9.90504724606832e-09 NA NA NA hsa-miR-375 HSPA12A -3.07641574130359 1.01411669962478e-67 0.744307320527785 3.33195317244489e-10 miRanda -0.264881940224166 7.75773627254833e-28 NA NA NA hsa-miR-375 HTR7 -3.07641574130359 1.01411669962478e-67 0.553428158535835 0.00122238010219364 miRanda -0.225045652921425 3.30588106384001e-10 NA NA NA hsa-miR-142-3p ID4 -0.668342567225765 0.000202408167795488 1.9483190517212 5.8950111617996e-24 miRanda -0.217983667245326 4.10585461380069e-06 NA NA NA hsa-miR-148a-5p ID4 -1.02522933532111 6.47121686767e-19 1.9483190517212 5.8950111617996e-24 MirTarget -0.672470178937594 4.19997864009973e-22 NA NA NA hsa-miR-186-5p ID4 -0.567811924899222 1.37607142180843e-13 1.9483190517212 5.8950111617996e-24 miRNAWalker2_validate;mirMAP -0.732571658761609 1.74800234665264e-11 NA NA NA hsa-miR-192-5p ID4 -0.245629178320703 0.0371144833362325 1.9483190517212 5.8950111617996e-24 miRNAWalker2_validate -0.466901577176106 9.52991948943276e-11 NA NA NA hsa-miR-203a-3p ID4 -0.963509686753836 7.73777501763897e-14 1.9483190517212 5.8950111617996e-24 MirTarget -0.2299175183388 0.000421906109307777 NA NA NA hsa-miR-335-5p ID4 -0.960193718665197 5.23061119483484e-12 1.9483190517212 5.8950111617996e-24 miRNAWalker2_validate -0.262626719575764 1.37216538288156e-05 21618216 Overexpression of miR-335 resulted in an upregulation of BRCA1 mRNA expression suggesting a functional dominance of ID4 signaling breast cancer hsa-miR-339-5p ID4 -0.986556478524229 2.39294233177812e-12 1.9483190517212 5.8950111617996e-24 miRanda -0.309526991255854 1.92749699881367e-07 NA NA NA hsa-miR-340-5p ID4 -0.418767158937088 8.44911569437027e-06 1.9483190517212 5.8950111617996e-24 miRNAWalker2_validate -0.291166890134012 0.0014374308416381 NA NA NA hsa-miR-342-3p ID4 -1.25856075011434 9.5039654565453e-34 1.9483190517212 5.8950111617996e-24 MirTarget;PITA;miRanda -0.347071898986832 7.71080657589585e-06 24475217 miR 342 regulates BRCA1 expression through modulation of ID4 in breast cancer; To investigate at functional level the role of miR-342 in the pathogenesis of breast cancer we focused our attention on its "in silico" predicted putative target gene ID4 a transcription factor of the helix-loop-helix protein family whose expression is inversely correlated with that of ER; We functionally validated the interaction between ID4 and miR-342 in a reporter Luciferase system; Based on these findings we hypothesized that regulation of ID4 mediated by miR-342 could be involved in the pathogenesis of breast cancer by downregulating BRCA1 expression; Overexpression of miR-342 in these cells reduced ID4 and increased BRCA1 expression supporting a possible role of this mechanism in breast cancer; In the ER-positive MCF7 and in the BRCA1-mutant HCC1937 cell lines miR-342 over-expression only reduced ID4 breast cancer hsa-miR-345-5p ID4 -0.396563568244736 0.00581846975378017 1.9483190517212 5.8950111617996e-24 MirTarget -0.226798797458831 0.000147377703095459 NA NA NA hsa-miR-532-3p ID4 -0.770066629498831 6.77162597488232e-10 1.9483190517212 5.8950111617996e-24 PITA -0.477974427584868 7.93113577693635e-13 NA NA NA hsa-miR-576-5p ID4 -0.962105441345164 5.68435745070752e-14 1.9483190517212 5.8950111617996e-24 mirMAP -0.553393064829019 4.16034693587886e-18 NA NA NA hsa-miR-590-3p ID4 -0.58484153433625 1.6489232844135e-06 1.9483190517212 5.8950111617996e-24 miRNAWalker2_validate;miRanda -0.431956603696378 4.43504291510037e-10 NA NA NA hsa-miR-590-5p ID4 -0.778106902153173 1.13576371947651e-09 1.9483190517212 5.8950111617996e-24 miRanda -0.465448006639824 9.32334883208509e-13 NA NA NA hsa-miR-629-3p ID4 -1.01531686151469 1.96827867612758e-09 1.9483190517212 5.8950111617996e-24 MirTarget -0.36637208029777 6.17792327129315e-13 NA NA NA hsa-miR-375 IFIT1 -3.07641574130359 1.01411669962478e-67 0.33500578193394 0.0660849800375525 miRNAWalker2_validate -0.159680758325479 3.2200201967577e-05 NA NA NA hsa-miR-375 IFIT2 -3.07641574130359 1.01411669962478e-67 0.636995897811469 2.79499029192744e-05 miRanda -0.250016039945625 2.44489645617833e-15 NA NA NA hsa-miR-375 IGF2BP2 -3.07641574130359 1.01411669962478e-67 1.24518532354637 6.16757436292096e-11 miRanda -0.44896655810525 4.98567619868962e-31 NA NA NA hsa-miR-375 IGFBP3 -3.07641574130359 1.01411669962478e-67 0.519212747582011 0.000268384596791624 miRNAWalker2_validate -0.189850041480671 1.97101542271714e-10 NA NA NA hsa-miR-375 IGFBP4 -3.07641574130359 1.01411669962478e-67 0.724550578421502 4.49123163081539e-08 miRanda -0.311204997659395 3.29509431515446e-31 NA NA NA hsa-miR-10b-5p INHBA -0.833433858224833 5.14196469408141e-10 -0.205841080740994 0.412956584659403 miRNAWalker2_validate -0.337849474818555 1.62389057205936e-05 NA NA NA hsa-miR-26b-5p INHBA -0.737437044119268 6.43607077094955e-18 -0.205841080740994 0.412956584659403 mirMAP -0.557705163581098 4.50917937217019e-06 NA NA NA hsa-miR-29a-5p INHBA -0.458517912323331 0.000412683536074951 -0.205841080740994 0.412956584659403 mirMAP -0.209995021344373 0.01081940036392 NA NA NA hsa-miR-30a-5p INHBA -0.508562243919922 3.02321261664392e-06 -0.205841080740994 0.412956584659403 mirMAP -0.807774475197757 2.03533066756318e-17 NA NA NA hsa-miR-30b-5p INHBA -1.16764575603669 1.75395013539893e-20 -0.205841080740994 0.412956584659403 mirMAP -0.522731081262359 1.04877610804895e-10 NA NA NA hsa-miR-30c-5p INHBA -0.746747513281496 1.32431877874928e-12 -0.205841080740994 0.412956584659403 mirMAP -0.913318254555115 2.70461886084898e-21 NA NA NA hsa-miR-30d-5p INHBA -0.804765144490435 1.42480384315577e-16 -0.205841080740994 0.412956584659403 mirMAP -0.291761597564789 0.00661939438437858 NA NA NA hsa-miR-30e-5p INHBA 0.0410434441382375 0.610918464525074 -0.205841080740994 0.412956584659403 mirMAP -0.417220268648285 0.00188276667597808 NA NA NA hsa-miR-374b-5p INHBA -0.221226738167835 0.00747242957932152 -0.205841080740994 0.412956584659403 mirMAP -0.675849602168512 1.75841620938162e-07 NA NA NA hsa-miR-664a-3p INHBA -0.771665734879283 3.09460128204882e-14 -0.205841080740994 0.412956584659403 mirMAP -0.693945694716984 8.39188848249472e-12 NA NA NA hsa-miR-9-5p INHBA -1.13944963456975 4.52386797543032e-07 -0.205841080740994 0.412956584659403 mirMAP -0.15461202825637 0.000963821426623429 NA NA NA hsa-miR-375 IP6K3 -3.07641574130359 1.01411669962478e-67 2.26318937143893 5.30103392477878e-15 miRanda -0.587854168517887 2.45986611340216e-22 NA NA NA hsa-miR-375 ISL2 -3.07641574130359 1.01411669962478e-67 1.06726951255686 6.26685802040205e-06 PITA;miRanda;miRNATAP -0.148525780189122 0.00319776716898177 NA NA NA hsa-miR-375 ITGB1 -3.07641574130359 1.01411669962478e-67 0.59506386112365 2.29420164914155e-18 miRNAWalker2_validate -0.166958917846226 7.0928215642965e-33 NA NA NA hsa-miR-375 ITGB1BP2 -3.07641574130359 1.01411669962478e-67 1.5385657702485 3.11214405699746e-15 miRNATAP -0.467470502524194 1.6132776212826e-31 NA NA NA hsa-miR-542-3p ITGBL1 0.31864941892079 0.0301489241026756 -1.75014567001747 1.26069136033302e-11 miRanda -0.30131005214507 7.72835841787723e-05 NA NA NA hsa-miR-375 ITM2A -3.07641574130359 1.01411669962478e-67 0.970084834926415 9.6645549989485e-08 miRanda -0.28642604699811 5.44331248358673e-14 NA NA NA hsa-miR-375 ITSN1 -3.07641574130359 1.01411669962478e-67 0.852508542354437 9.38074774207031e-27 miRanda -0.228713101213806 5.29896715938341e-45 NA NA NA hsa-miR-375 JAK2 -3.07641574130359 1.01411669962478e-67 0.677767846910182 5.52741950770812e-14 miRNAWalker2_validate;miRTarBase;miRanda;miRNATAP -0.17397637413054 2.65916776140565e-20 20548334;25055044;21557705 MiR 375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2; Either inhibition of JAK2 activity by AG490 or silencing of JAK2 by RNAi suppressed gastric cancer cell proliferation resembling that of miR-375 overexpression; Moreover ectopic expression of JAK2 can partially reverse the inhibition of cell proliferation caused by miR-375; Finally we found a significant inverse correlation between miR-375 expression and JAK2 protein level in gastric cancer; Thus these data suggest that miR-375 may function as a tumor suppressor to regulate gastric cancer cell proliferation potentially by targeting the JAK2 oncogene implicating a role of miR-375 in the pathogenesis of gastric cancer;Snail regulated MiR 375 inhibits migration and invasion of gastric cancer cells by targeting JAK2; Our previous study showed that miR-375 frequently downregulated in gastric cancer suppresses cell proliferation by targeting Janus kinase 2 JAK2; Ectopic expression of miR-375 inhibits the migration and invasion of gastric cancer cells partially by targeting JAK2; Taken together these data suggest that miR-375 may be negatively regulated by Snail and involved in gastric cancer cell migration and invasion potentially by targeting JAK2;The genes targeted by miR-375 including JAK2 and 3'-phosphoinositide dependent protein kinase-1 PDK1 are also candidates for gastric cancer therapy ;cell migration; gastric cancer;gastric cancer;gastric cancer hsa-miR-375 KANK2 -3.07641574130359 1.01411669962478e-67 1.17282924957112 1.01639896133097e-21 miRanda -0.368589802047132 2.7544760203839e-51 NA NA NA hsa-miR-375 KANK4 -3.07641574130359 1.01411669962478e-67 1.57499819318292 9.65509715371569e-12 miRNATAP -0.362390400779757 1.18135144637251e-13 NA NA NA hsa-miR-375 KCNAB1 -3.07641574130359 1.01411669962478e-67 1.7223719415227 1.35881296974686e-19 miRNATAP -0.446104656360472 1.52343205067702e-29 NA NA NA hsa-miR-375 KCNE3 -3.07641574130359 1.01411669962478e-67 1.12523443138842 4.85246115861904e-10 miRNATAP -0.326155870997781 5.2794987392738e-18 NA NA NA hsa-miR-193a-3p KCNH8 0.289173667055148 0.027278888130977 -1.50274727359706 2.63121344741602e-06 PITA;miRanda;miRNATAP -0.414909269158341 7.70838321150075e-05 NA NA NA hsa-miR-193a-5p KCNH8 -0.157102231934963 0.0961754074445838 -1.50274727359706 2.63121344741602e-06 PITA;TargetScan -0.379685048314352 0.00972666494983124 NA NA NA hsa-miR-193b-3p KCNH8 -0.425830265253153 0.00142308830221877 -1.50274727359706 2.63121344741602e-06 miRNATAP -0.587242732630245 7.9786868447519e-09 NA NA NA hsa-miR-199a-3p KCNH8 0.0553473600849195 0.587002550685305 -1.50274727359706 2.63121344741602e-06 PITA -0.310627258427518 0.0225317344436693 NA NA NA hsa-miR-199b-3p KCNH8 0.0592501088066051 0.561598445904767 -1.50274727359706 2.63121344741602e-06 PITA;miRNATAP -0.31088963804095 0.0221752491503633 NA NA NA hsa-miR-28-5p KCNH8 -0.142043455520843 0.0231808012790841 -1.50274727359706 2.63121344741602e-06 miRanda -0.935092987955233 2.76560912530107e-05 NA NA NA hsa-miR-3065-5p KCNH8 -1.04645334963496 3.19942342920484e-08 -1.50274727359706 2.63121344741602e-06 mirMAP -0.410221493576801 1.22007167309176e-08 NA NA NA hsa-miR-324-5p KCNH8 -0.539970285576229 1.69955273262756e-05 -1.50274727359706 2.63121344741602e-06 miRanda -0.281139661392298 0.0100505338617356 NA NA NA hsa-miR-362-3p KCNH8 -0.332355427232084 0.0356765384646951 -1.50274727359706 2.63121344741602e-06 miRanda -0.406480839313351 3.45344054664049e-06 NA NA NA hsa-miR-486-5p KCNH8 0.572011250438858 0.00125387759748306 -1.50274727359706 2.63121344741602e-06 MirTarget;PITA;miRanda -0.390381395405124 3.6351108705551e-07 NA NA NA hsa-miR-508-3p KCNH8 0.564537868062026 0.0283329210776803 -1.50274727359706 2.63121344741602e-06 miRNATAP -0.115208226351826 0.0377067591045917 NA NA NA hsa-miR-532-3p KCNH8 -0.770066629498831 6.77162597488232e-10 -1.50274727359706 2.63121344741602e-06 MirTarget -0.315566628730283 0.0037356864814766 NA NA NA hsa-miR-590-3p KCNH8 -0.58484153433625 1.6489232844135e-06 -1.50274727359706 2.63121344741602e-06 miRanda -0.24692212567386 0.0281439880309884 NA NA NA hsa-miR-375 KCNJ3 -3.07641574130359 1.01411669962478e-67 2.96698054492848 6.3247374973002e-20 miRanda -0.772969586890426 1.9217077385001e-30 NA NA NA hsa-miR-375 KCNN4 -3.07641574130359 1.01411669962478e-67 0.294592826835498 0.360353461498694 miRNAWalker2_validate -0.157330807513334 0.0210194414909511 NA NA NA hsa-miR-375 KCNQ5 -3.07641574130359 1.01411669962478e-67 1.80720854815239 7.23102629256069e-19 miRanda -0.467734083524326 2.51407311432106e-28 NA NA NA hsa-miR-375 KCNT2 -3.07641574130359 1.01411669962478e-67 1.237916713498 4.26850132798383e-08 mirMAP -0.407688811612018 3.77939187836772e-18 NA NA NA hsa-miR-375 KCTD10 -3.07641574130359 1.01411669962478e-67 0.308247466795525 1.91292485721862e-06 miRNAWalker2_validate -0.127224319717872 8.58730981829477e-22 NA NA NA hsa-miR-375 KIAA0513 -3.07641574130359 1.01411669962478e-67 0.518877565684561 8.21164992464784e-07 miRNAWalker2_validate -0.150428304054205 9.46798415144989e-12 NA NA NA hsa-miR-375 KLF12 -3.07641574130359 1.01411669962478e-67 0.728086660554206 1.16601001789849e-08 miRNATAP -0.255525590636838 2.66943062421683e-22 NA NA NA hsa-miR-375 KLF5 -3.07641574130359 1.01411669962478e-67 1.08155388875191 9.36060334470391e-14 miRNATAP -0.291987846274814 4.9835940532996e-22 NA NA NA hsa-miR-375 KLF7 -3.07641574130359 1.01411669962478e-67 0.739380679410425 1.00323341165226e-06 miRNATAP -0.253033661729677 8.82807919400196e-16 NA NA NA hsa-let-7a-3p KLF8 -0.885792199222571 4.41035630133324e-17 1.16793646031326 2.47501963724714e-19 mirMAP -0.560845855665457 7.32369709433135e-29 NA NA NA hsa-let-7a-5p KLF8 -0.810823676990507 1.01381033479519e-26 1.16793646031326 2.47501963724714e-19 TargetScan;miRNATAP -0.605260376773943 1.0910200419121e-17 NA NA NA hsa-let-7b-3p KLF8 -0.506893427781244 8.27914591468333e-08 1.16793646031326 2.47501963724714e-19 mirMAP -0.389389162194806 5.5678451063298e-11 NA NA NA hsa-let-7b-5p KLF8 -0.221439854958536 0.00904814983284487 1.16793646031326 2.47501963724714e-19 miRNATAP -0.241250013096943 0.00038620323975409 NA NA NA hsa-let-7d-5p KLF8 -0.767545769968654 1.765411565791e-19 1.16793646031326 2.47501963724714e-19 miRNATAP -0.556898438469531 2.16559291557512e-18 NA NA NA hsa-let-7f-5p KLF8 -0.832261132545632 1.30765336262194e-16 1.16793646031326 2.47501963724714e-19 miRNATAP -0.171210104169161 0.00208179546350818 NA NA NA hsa-let-7g-5p KLF8 -0.614367845078204 1.65972787509666e-17 1.16793646031326 2.47501963724714e-19 miRNATAP -0.55318011870121 4.75410086630511e-13 NA NA NA hsa-miR-126-5p KLF8 -0.222731872217005 0.0500978215521652 1.16793646031326 2.47501963724714e-19 mirMAP -0.100557115971158 0.0474323596215968 NA NA NA hsa-miR-140-5p KLF8 -0.714046975295031 8.18104415848501e-20 1.16793646031326 2.47501963724714e-19 miRanda -0.309657265311222 1.28407212613652e-05 NA NA NA hsa-miR-146b-5p KLF8 -1.70281490248323 9.08060943822522e-35 1.16793646031326 2.47501963724714e-19 miRanda -0.171616961051632 8.90700229471473e-06 NA NA NA hsa-miR-16-2-3p KLF8 -0.615426607127207 4.13943192730969e-05 1.16793646031326 2.47501963724714e-19 mirMAP -0.20206972020116 1.57714064491397e-07 NA NA NA hsa-miR-186-5p KLF8 -0.567811924899222 1.37607142180843e-13 1.16793646031326 2.47501963724714e-19 mirMAP -0.576161123724647 1.19804670602662e-15 NA NA NA hsa-miR-3065-3p KLF8 -1.23044918674587 2.31797828811622e-15 1.16793646031326 2.47501963724714e-19 miRNATAP -0.141515286621226 7.9147009558841e-05 NA NA NA hsa-miR-3065-5p KLF8 -1.04645334963496 3.19942342920484e-08 1.16793646031326 2.47501963724714e-19 miRNATAP -0.145811760032488 1.30624125695797e-06 NA NA NA hsa-miR-30b-5p KLF8 -1.16764575603669 1.75395013539893e-20 1.16793646031326 2.47501963724714e-19 mirMAP -0.395831253081477 1.13554008390171e-20 NA NA NA hsa-miR-30c-5p KLF8 -0.746747513281496 1.32431877874928e-12 1.16793646031326 2.47501963724714e-19 mirMAP;miRNATAP -0.228178730200527 1.87510146975403e-05 NA NA NA hsa-miR-30d-5p KLF8 -0.804765144490435 1.42480384315577e-16 1.16793646031326 2.47501963724714e-19 mirMAP;miRNATAP -0.441046678477143 3.92248416620784e-15 NA NA NA hsa-miR-320a KLF8 -0.995486653328464 1.19389676663012e-20 1.16793646031326 2.47501963724714e-19 mirMAP -0.209744891123348 5.01506269761744e-05 NA NA NA hsa-miR-324-5p KLF8 -0.539970285576229 1.69955273262756e-05 1.16793646031326 2.47501963724714e-19 miRanda -0.219078218442132 1.23214730621908e-06 NA NA NA hsa-miR-335-5p KLF8 -0.960193718665197 5.23061119483484e-12 1.16793646031326 2.47501963724714e-19 miRNAWalker2_validate -0.127994921954765 0.00154141016570035 NA NA NA hsa-miR-33a-3p KLF8 -0.612459021907227 0.000347410219059134 1.16793646031326 2.47501963724714e-19 mirMAP -0.236330271264446 1.69930073688044e-12 NA NA NA hsa-miR-340-5p KLF8 -0.418767158937088 8.44911569437027e-06 1.16793646031326 2.47501963724714e-19 mirMAP -0.178836342239934 0.0033357051453353 NA NA NA hsa-miR-342-3p KLF8 -1.25856075011434 9.5039654565453e-34 1.16793646031326 2.47501963724714e-19 miRanda -0.266502358302398 2.34986579330023e-07 NA NA NA hsa-miR-3607-3p KLF8 -1.16606393006353 2.28951370382029e-07 1.16793646031326 2.47501963724714e-19 MirTarget;miRNATAP -0.156628172047702 2.6458446663406e-10 NA NA NA hsa-miR-3653-3p KLF8 -1.31041121546999 4.84948862243673e-14 1.16793646031326 2.47501963724714e-19 MirTarget -0.214596315426029 1.18907975472864e-11 NA NA NA hsa-miR-491-5p KLF8 -0.996821208926168 6.43686029153545e-11 1.16793646031326 2.47501963724714e-19 miRanda -0.243619031252463 2.56415540632762e-11 NA NA NA hsa-miR-590-3p KLF8 -0.58484153433625 1.6489232844135e-06 1.16793646031326 2.47501963724714e-19 miRanda;mirMAP -0.285568139442525 6.18076212573172e-10 NA NA NA hsa-miR-590-5p KLF8 -0.778106902153173 1.13576371947651e-09 1.16793646031326 2.47501963724714e-19 miRanda -0.304365708799266 2.57310707586885e-12 NA NA NA hsa-miR-7-1-3p KLF8 -1.45703750327525 1.75378847810364e-30 1.16793646031326 2.47501963724714e-19 MirTarget -0.496973497671702 2.22389997446096e-35 NA NA NA hsa-miR-375 KLHDC1 -3.07641574130359 1.01411669962478e-67 0.685639233833843 1.21396857540448e-13 miRanda -0.167951246811204 4.9906522367091e-18 NA NA NA hsa-miR-375 KLK10 -3.07641574130359 1.01411669962478e-67 0.742343338846854 0.00170265450841025 miRNAWalker2_validate -0.156275178837487 0.0018450364119564 NA NA NA hsa-miR-339-5p KRR1 -0.986556478524229 2.39294233177812e-12 0.0517765063526552 0.413497859489199 miRanda -0.128774388596782 2.49482376036865e-12 NA NA NA hsa-miR-342-3p KRR1 -1.25856075011434 9.5039654565453e-34 0.0517765063526552 0.413497859489199 miRanda -0.120113029207034 6.82339307338462e-07 NA NA NA hsa-miR-361-5p KRR1 -0.652200980992921 2.23302456529972e-21 0.0517765063526552 0.413497859489199 miRanda -0.139073185079469 0.00025965417537169 NA NA NA hsa-miR-500a-5p KRR1 -0.724031963091637 1.07520204401534e-07 0.0517765063526552 0.413497859489199 MirTarget -0.140657491582683 2.33707854696121e-13 NA NA NA hsa-miR-141-3p KRT222 -1.79566520772936 2.43414267305203e-29 0.956880563411111 1.12401787108751e-25 TargetScan -0.171465407327964 4.89808559836941e-13 NA NA NA hsa-miR-26b-5p KRT222 -0.737437044119268 6.43607077094955e-18 0.956880563411111 1.12401787108751e-25 miRNAWalker2_validate -0.234471876830704 3.9695591944262e-07 NA NA NA hsa-miR-339-5p KRT222 -0.986556478524229 2.39294233177812e-12 0.956880563411111 1.12401787108751e-25 miRanda -0.130680140982086 3.80195353108703e-06 NA NA NA hsa-miR-340-5p KRT222 -0.418767158937088 8.44911569437027e-06 0.956880563411111 1.12401787108751e-25 MirTarget -0.134034616992857 0.00198656827712098 NA NA NA hsa-miR-589-5p KRT222 -0.816440979173972 2.93437435111593e-17 0.956880563411111 1.12401787108751e-25 MirTarget -0.203385095568206 6.58053292947765e-07 NA NA NA hsa-miR-375 KYNU -3.07641574130359 1.01411669962478e-67 0.0597424346807998 0.76584330099437 miRanda -0.17410751721977 3.71797228508811e-05 NA NA NA hsa-miR-375 LAMA2 -3.07641574130359 1.01411669962478e-67 0.732203401728377 6.95505079513508e-05 miRanda -0.29769325036845 7.07100357762987e-15 NA NA NA hsa-miR-375 LAMB1 -3.07641574130359 1.01411669962478e-67 0.637172940016089 3.74797964423088e-06 miRanda -0.259727140067535 5.84101989987703e-20 NA NA NA hsa-miR-375 LAMP3 -3.07641574130359 1.01411669962478e-67 0.80963800949695 0.000111643403218363 miRanda -0.270805277884918 7.37176008066811e-10 NA NA NA hsa-miR-106a-5p LDB3 -1.76751200862602 7.79031604495387e-24 2.12978386401984 1.41250437091222e-19 mirMAP -0.417219875813881 5.19628160140598e-14 NA NA NA hsa-miR-106b-5p LDB3 -1.03194006819592 5.97693261279532e-24 2.12978386401984 1.41250437091222e-19 mirMAP -1.03323789797028 8.53178342938405e-29 NA NA NA hsa-miR-130b-5p LDB3 -1.15237450600836 1.6187151436434e-14 2.12978386401984 1.41250437091222e-19 mirMAP -0.619107594196766 2.04934452141645e-21 NA NA NA hsa-miR-140-5p LDB3 -0.714046975295031 8.18104415848501e-20 2.12978386401984 1.41250437091222e-19 miRanda -0.626887222546958 1.04920580724093e-06 NA NA NA hsa-miR-142-5p LDB3 -0.570537423718147 5.59576699766966e-05 2.12978386401984 1.41250437091222e-19 mirMAP -0.207172263195132 0.00460340842703366 NA NA NA hsa-miR-146b-5p LDB3 -1.70281490248323 9.08060943822522e-35 2.12978386401984 1.41250437091222e-19 miRanda -0.480456197101862 3.68059790733295e-12 NA NA NA hsa-miR-17-5p LDB3 -1.75236465070226 3.95158641627966e-36 2.12978386401984 1.41250437091222e-19 mirMAP -0.732427465933237 1.62873913946564e-28 NA NA NA hsa-miR-19a-3p LDB3 -1.31708679186777 4.80964007387792e-14 2.12978386401984 1.41250437091222e-19 mirMAP -0.427874242426609 5.01795125109967e-14 NA NA NA hsa-miR-19b-3p LDB3 -1.59390221063917 1.21812878827867e-26 2.12978386401984 1.41250437091222e-19 mirMAP -0.587475016340529 5.22207039475256e-20 NA NA NA hsa-miR-20a-5p LDB3 -1.8613782696103 3.92351368893149e-34 2.12978386401984 1.41250437091222e-19 mirMAP -0.655570907938716 4.12061467117478e-27 NA NA NA hsa-miR-20b-5p LDB3 -1.58314196476133 5.61327965534576e-17 2.12978386401984 1.41250437091222e-19 mirMAP -0.391846985437023 5.9586428720936e-14 NA NA NA hsa-miR-29b-1-5p LDB3 -1.06520673410615 4.43912716822897e-11 2.12978386401984 1.41250437091222e-19 mirMAP -0.286589588219707 1.01765501733346e-05 NA NA NA hsa-miR-320a LDB3 -0.995486653328464 1.19389676663012e-20 2.12978386401984 1.41250437091222e-19 mirMAP -0.297461779768531 0.00156431833338051 NA NA NA hsa-miR-324-5p LDB3 -0.539970285576229 1.69955273262756e-05 2.12978386401984 1.41250437091222e-19 miRanda -0.276068755054486 0.000801493285173754 NA NA NA hsa-miR-340-5p LDB3 -0.418767158937088 8.44911569437027e-06 2.12978386401984 1.41250437091222e-19 mirMAP -0.689517348677482 2.42406222542507e-10 NA NA NA hsa-miR-342-3p LDB3 -1.25856075011434 9.5039654565453e-34 2.12978386401984 1.41250437091222e-19 miRanda -0.549173189142314 3.70526876847303e-09 NA NA NA hsa-miR-361-3p LDB3 -0.577270981783871 4.74678124050069e-11 2.12978386401984 1.41250437091222e-19 miRNATAP -0.414692945207388 0.000396757982094218 NA NA NA hsa-miR-375 LDB3 -3.07641574130359 1.01411669962478e-67 2.12978386401984 1.41250437091222e-19 miRanda -0.605272789030619 4.42709154514316e-36 NA NA NA hsa-miR-429 LDB3 -0.682420529994949 0.00462213397220848 2.12978386401984 1.41250437091222e-19 miRanda;miRNATAP -0.199273596943168 3.20009192970138e-06 NA NA NA hsa-miR-576-5p LDB3 -0.962105441345164 5.68435745070752e-14 2.12978386401984 1.41250437091222e-19 mirMAP -0.757357991384385 3.16393002296866e-23 NA NA NA hsa-miR-590-3p LDB3 -0.58484153433625 1.6489232844135e-06 2.12978386401984 1.41250437091222e-19 miRanda -0.611883766449214 1.79215054121948e-13 NA NA NA hsa-miR-93-5p LDB3 -2.02673564951393 4.11722430511061e-49 2.12978386401984 1.41250437091222e-19 mirMAP -0.821537223707055 1.92443799430175e-37 NA NA NA hsa-miR-375 LDHB -3.07641574130359 1.01411669962478e-67 0.924974141692911 5.6938752811737e-09 miRNAWalker2_validate;miRanda;miRNATAP -0.287485014772568 3.24735587663076e-18 22752059 The restoration of miR-375 suppressed the expression of LDHB and AEG-1/MTDH; LDHB which is regulated by the tumor suppressive miR-375 may therefore act as an oncogene in ESCC esophageal cancer hsa-miR-375 LGR5 -3.07641574130359 1.01411669962478e-67 1.02967696581054 2.01521768245229e-06 miRanda -0.366538398991695 4.11069421095447e-16 NA NA NA hsa-miR-375 LHFPL2 -3.07641574130359 1.01411669962478e-67 0.817541491381935 1.33444194793909e-14 miRNAWalker2_validate -0.307141642534168 2.10281654216181e-48 NA NA NA hsa-miR-126-5p LRCH2 -0.222731872217005 0.0500978215521652 1.55270937318372 1.50716041158258e-15 MirTarget;mirMAP;miRNATAP -0.327726168501685 1.22115493754107e-05 NA NA NA hsa-miR-130b-3p LRCH2 -1.0141083264891 9.96856467852323e-16 1.55270937318372 1.50716041158258e-15 MirTarget;miRNATAP -0.39147165386945 1.72468220744972e-09 NA NA NA hsa-miR-17-3p LRCH2 -1.00900556864081 4.33187133364694e-23 1.55270937318372 1.50716041158258e-15 MirTarget -0.706801149725556 1.18427603153454e-19 NA NA NA hsa-miR-182-5p LRCH2 -2.57717136150549 4.94377928074908e-59 1.55270937318372 1.50716041158258e-15 miRNATAP -0.557878461950761 1.62156517824831e-35 NA NA NA hsa-miR-186-5p LRCH2 -0.567811924899222 1.37607142180843e-13 1.55270937318372 1.50716041158258e-15 MirTarget;miRNATAP -0.911828878294723 1.22009842434276e-17 NA NA NA hsa-miR-194-5p LRCH2 -0.560678555035275 8.78835428037523e-09 1.55270937318372 1.50716041158258e-15 MirTarget -0.621109964039971 2.92526970741067e-13 NA NA NA hsa-miR-19a-3p LRCH2 -1.31708679186777 4.80964007387792e-14 1.55270937318372 1.50716041158258e-15 miRNATAP -0.345016923791995 1.41132652224283e-13 NA NA NA hsa-miR-19b-3p LRCH2 -1.59390221063917 1.21812878827867e-26 1.55270937318372 1.50716041158258e-15 miRNATAP -0.48278321623763 4.49089606812574e-20 NA NA NA hsa-miR-301a-3p LRCH2 -0.501721475120081 0.000262747397142621 1.55270937318372 1.50716041158258e-15 MirTarget;miRNATAP -0.220179332602705 0.000367996459211308 NA NA NA hsa-miR-30b-5p LRCH2 -1.16764575603669 1.75395013539893e-20 1.55270937318372 1.50716041158258e-15 MirTarget -0.529481252403414 9.0419674281254e-17 NA NA NA hsa-miR-30c-5p LRCH2 -0.746747513281496 1.32431877874928e-12 1.55270937318372 1.50716041158258e-15 MirTarget;miRNATAP -0.345149301732566 1.34439822710514e-05 NA NA NA hsa-miR-30d-5p LRCH2 -0.804765144490435 1.42480384315577e-16 1.55270937318372 1.50716041158258e-15 MirTarget;miRNATAP -0.75681171338048 5.4685095362983e-20 NA NA NA hsa-miR-30e-5p LRCH2 0.0410434441382375 0.610918464525074 1.55270937318372 1.50716041158258e-15 MirTarget -0.256840921183897 0.01649860249465 NA NA NA hsa-miR-324-5p LRCH2 -0.539970285576229 1.69955273262756e-05 1.55270937318372 1.50716041158258e-15 miRanda -0.370388307814147 3.19165639379743e-08 NA NA NA hsa-miR-335-5p LRCH2 -0.960193718665197 5.23061119483484e-12 1.55270937318372 1.50716041158258e-15 miRNAWalker2_validate -0.223324281795934 0.000198456584994988 NA NA NA hsa-miR-33a-3p LRCH2 -0.612459021907227 0.000347410219059134 1.55270937318372 1.50716041158258e-15 MirTarget;miRNATAP -0.277382867981653 3.39678135792248e-08 NA NA NA hsa-miR-340-5p LRCH2 -0.418767158937088 8.44911569437027e-06 1.55270937318372 1.50716041158258e-15 mirMAP -0.386989925577793 1.79677231814128e-05 NA NA NA hsa-miR-34c-5p LRCH2 -0.411316782408141 0.0146968432653683 1.55270937318372 1.50716041158258e-15 miRanda -0.111706783027307 0.0279931947962393 NA NA NA hsa-miR-361-5p LRCH2 -0.652200980992921 2.23302456529972e-21 1.55270937318372 1.50716041158258e-15 miRanda -0.350644915675397 0.00379182135949777 NA NA NA hsa-miR-429 LRCH2 -0.682420529994949 0.00462213397220848 1.55270937318372 1.50716041158258e-15 miRanda;miRNATAP -0.159142380018798 5.8653170984589e-06 NA NA NA hsa-miR-454-3p LRCH2 -1.05348676011504 1.08188735671628e-16 1.55270937318372 1.50716041158258e-15 MirTarget;miRNATAP -0.450244455121633 2.37473312712477e-12 NA NA NA hsa-miR-590-3p LRCH2 -0.58484153433625 1.6489232844135e-06 1.55270937318372 1.50716041158258e-15 miRanda;mirMAP -0.385968929303325 2.107848896318e-08 NA NA NA hsa-miR-664a-3p LRCH2 -0.771665734879283 3.09460128204882e-14 1.55270937318372 1.50716041158258e-15 MirTarget;mirMAP -0.523679345672794 1.06450506479227e-10 NA NA NA hsa-miR-7-1-3p LRCH2 -1.45703750327525 1.75378847810364e-30 1.55270937318372 1.50716041158258e-15 mirMAP -0.649336708952258 8.57239545187938e-27 NA NA NA hsa-miR-708-3p LRCH2 -1.69343810530707 2.2954130070805e-38 1.55270937318372 1.50716041158258e-15 MirTarget -0.409404804405876 6.97947535377635e-12 NA NA NA hsa-miR-96-5p LRCH2 -2.57339472553563 5.77311209747623e-53 1.55270937318372 1.50716041158258e-15 MirTarget;TargetScan;miRNATAP -0.55150804413438 4.25831731851363e-38 NA NA NA hsa-miR-375 LRP1B -3.07641574130359 1.01411669962478e-67 2.22141219260001 6.65751085224568e-18 miRanda -0.655487802380789 1.82868317092371e-35 NA NA NA hsa-miR-375 LRRC43 -3.07641574130359 1.01411669962478e-67 1.09206381207419 4.49047411685395e-09 miRanda -0.296602003240243 3.16566263543487e-14 NA NA NA hsa-miR-375 LST1 -3.07641574130359 1.01411669962478e-67 0.0301751608694447 0.84130759670765 miRNATAP -0.111277335124799 0.000461664933975154 NA NA NA hsa-miR-15b-3p LUZP2 -0.70449098511926 1.79992266779526e-09 -2.54301139453296 1.01655208509924e-20 mirMAP -0.226530682952077 0.0263587694355994 NA NA NA hsa-miR-16-2-3p LUZP2 -0.615426607127207 4.13943192730969e-05 -2.54301139453296 1.01655208509924e-20 mirMAP -0.274993284050333 0.000762412002589154 NA NA NA hsa-miR-181a-5p LUZP2 -0.345696423622306 0.000458417065949032 -2.54301139453296 1.01655208509924e-20 mirMAP -0.332378324457346 0.00670247188287187 NA NA NA hsa-miR-181b-5p LUZP2 -0.0216723299660488 0.812298103317658 -2.54301139453296 1.01655208509924e-20 mirMAP -0.372207748573457 0.00528251775953266 NA NA NA hsa-miR-181c-5p LUZP2 0.216106163143198 0.0372442927577835 -2.54301139453296 1.01655208509924e-20 mirMAP -0.260680886860426 0.0259289127857157 NA NA NA hsa-miR-205-5p LUZP2 1.20860500357398 0.000188855069045762 -2.54301139453296 1.01655208509924e-20 mirMAP -0.141364000376085 0.000130625199638229 NA NA NA hsa-miR-221-3p LUZP2 1.24494692780126 3.24056780178367e-20 -2.54301139453296 1.01655208509924e-20 MirTarget -0.41383940503597 1.34163173646588e-06 NA NA NA hsa-miR-222-3p LUZP2 0.953446345586856 1.89596390370395e-13 -2.54301139453296 1.01655208509924e-20 MirTarget -0.460059414338616 3.65437074923952e-07 NA NA NA hsa-miR-338-5p LUZP2 1.0222700595457 1.2342974008659e-09 -2.54301139453296 1.01655208509924e-20 mirMAP -0.192965722937619 0.0067580100777387 NA NA NA hsa-miR-339-5p LUZP2 -0.986556478524229 2.39294233177812e-12 -2.54301139453296 1.01655208509924e-20 miRanda -0.284324222985053 0.000709920597600602 NA NA NA hsa-miR-34c-3p LUZP2 0.518747397740078 0.00158532638288121 -2.54301139453296 1.01655208509924e-20 mirMAP -0.308838654195675 2.84762387762752e-05 NA NA NA hsa-miR-369-3p LUZP2 0.519609525776978 0.000489324873973287 -2.54301139453296 1.01655208509924e-20 MirTarget -0.398262983164282 6.85663013613849e-07 NA NA NA hsa-miR-539-5p LUZP2 -0.199350141954634 0.252691751194608 -2.54301139453296 1.01655208509924e-20 MirTarget -0.229320874249716 0.00127723490517185 NA NA NA hsa-miR-590-5p LUZP2 -0.778106902153173 1.13576371947651e-09 -2.54301139453296 1.01655208509924e-20 miRanda -0.2298934045069 0.0137508354815976 NA NA NA hsa-miR-375 LYPD5 -3.07641574130359 1.01411669962478e-67 0.562552778619654 3.05477532732725e-05 miRNAWalker2_validate -0.160988322996205 1.45737535051434e-08 NA NA NA hsa-miR-375 MACROD2 -3.07641574130359 1.01411669962478e-67 0.48665542396584 0.000128270610266911 miRanda -0.121502006309793 6.09825300336598e-06 NA NA NA hsa-miR-375 MAEL -3.07641574130359 1.01411669962478e-67 1.27681803063569 1.13247806386834e-07 miRanda;miRNATAP -0.353617280848824 2.71557841141562e-12 NA NA NA hsa-miR-375 MAN1A2 -3.07641574130359 1.01411669962478e-67 0.447885202600091 5.14385978777193e-05 miRanda -0.117388593560653 4.94499536191331e-07 NA NA NA hsa-miR-375 MAP1LC3B -3.07641574130359 1.01411669962478e-67 0.568577927449319 2.76985969612541e-20 miRanda -0.124343738583535 1.02001132707282e-21 NA NA NA hsa-miR-375 MAP3K8 -3.07641574130359 1.01411669962478e-67 0.708318544756139 4.99515702196914e-06 miRNAWalker2_validate -0.346639431507377 2.88653454306994e-28 NA NA NA hsa-miR-375 MAPRE2 -3.07641574130359 1.01411669962478e-67 0.537704149609166 5.36335724191443e-06 miRanda -0.204699781128604 6.4091617669178e-17 NA NA NA hsa-miR-375 MAST4 -3.07641574130359 1.01411669962478e-67 1.05352444479233 8.69211459830895e-11 miRanda;miRNATAP -0.297985224392433 1.44312638406099e-18 NA NA NA hsa-miR-375 MAT2B -3.07641574130359 1.01411669962478e-67 0.677130373262056 1.65455577800176e-32 miRNAWalker2_validate;miRanda -0.179482372521387 1.31374091491067e-54 NA NA NA hsa-miR-375 MATN2 -3.07641574130359 1.01411669962478e-67 0.989241044615334 6.70024135421673e-12 miRanda -0.350744946615127 4.23264618409499e-33 NA NA NA hsa-miR-375 MBNL1 -3.07641574130359 1.01411669962478e-67 0.588831588092938 6.24283494637158e-19 miRNATAP -0.172499607598559 2.10591807642288e-37 NA NA NA hsa-miR-375 MBNL3 -3.07641574130359 1.01411669962478e-67 1.53272365667821 9.24753943788601e-12 miRNATAP -0.380368721318937 8.70896016766063e-16 NA NA NA hsa-let-7a-3p MECOM -0.885792199222571 4.41035630133324e-17 1.53075835181878 5.8991988556176e-23 miRNATAP -0.565970154242368 4.19772131702211e-20 NA NA NA hsa-let-7b-3p MECOM -0.506893427781244 8.27914591468333e-08 1.53075835181878 5.8991988556176e-23 miRNATAP -0.419107875326199 5.26184151918897e-09 NA NA NA hsa-miR-182-5p MECOM -2.57717136150549 4.94377928074908e-59 1.53075835181878 5.8991988556176e-23 miRNATAP -0.435680266279114 7.08609158986633e-33 NA NA NA hsa-miR-19a-3p MECOM -1.31708679186777 4.80964007387792e-14 1.53075835181878 5.8991988556176e-23 miRNATAP -0.337223167611451 1.51236935320651e-19 NA NA NA hsa-miR-19b-3p MECOM -1.59390221063917 1.21812878827867e-26 1.53075835181878 5.8991988556176e-23 miRNATAP -0.503563388684025 4.5206056585242e-34 NA NA NA hsa-miR-28-3p MECOM -0.464592918249583 2.99677077334845e-12 1.53075835181878 5.8991988556176e-23 miRNATAP -0.228766105026264 0.0268486881482698 NA NA NA hsa-miR-3065-5p MECOM -1.04645334963496 3.19942342920484e-08 1.53075835181878 5.8991988556176e-23 miRNATAP -0.161122147157635 9.19737868221323e-06 NA NA NA hsa-miR-361-5p MECOM -0.652200980992921 2.23302456529972e-21 1.53075835181878 5.8991988556176e-23 miRanda -0.654353392041568 1.09418822150473e-11 NA NA NA hsa-miR-362-3p MECOM -0.332355427232084 0.0356765384646951 1.53075835181878 5.8991988556176e-23 miRanda -0.143188188938462 0.00117994281725453 NA NA NA hsa-miR-374b-5p MECOM -0.221226738167835 0.00747242957932152 1.53075835181878 5.8991988556176e-23 mirMAP -0.203117805592842 0.0158677818971691 NA NA NA hsa-miR-582-5p MECOM -0.306116891157888 0.0402663500947968 1.53075835181878 5.8991988556176e-23 miRNATAP -0.353479846586757 5.05647133872808e-15 NA NA NA hsa-miR-590-3p MECOM -0.58484153433625 1.6489232844135e-06 1.53075835181878 5.8991988556176e-23 miRanda -0.300619725954912 7.12188749148207e-08 NA NA NA hsa-miR-96-5p MECOM -2.57339472553563 5.77311209747623e-53 1.53075835181878 5.8991988556176e-23 TargetScan;miRNATAP -0.455656970461277 6.19632500391756e-40 NA NA NA hsa-miR-375 MECP2 -3.07641574130359 1.01411669962478e-67 0.372770969874175 6.17835628488988e-15 mirMAP -0.103312654087383 1.07019019139497e-25 NA NA NA hsa-miR-375 MEIS1 -3.07641574130359 1.01411669962478e-67 1.32816619017208 2.25330112170345e-17 miRanda;miRNATAP -0.452083554366352 2.09153410661575e-47 NA NA NA hsa-miR-375 MITF -3.07641574130359 1.01411669962478e-67 0.770695163808188 3.59703297995528e-12 miRanda -0.289325301759688 1.30567997124465e-38 NA NA NA hsa-miR-375 MMD -3.07641574130359 1.01411669962478e-67 0.413464934851395 2.65888858662294e-06 miRanda;miRNATAP -0.183309215237092 1.95584887488215e-24 NA NA NA hsa-miR-1266-5p MME -0.973179154209445 2.14755153773861e-10 1.50585723570184 5.75472154597638e-09 MirTarget -0.240170725389135 0.000861268465683505 NA NA NA hsa-miR-128-3p MME -0.314011160241606 0.000267378314657252 1.50585723570184 5.75472154597638e-09 MirTarget -0.334013702542037 0.010445064224516 NA NA NA hsa-miR-148a-5p MME -1.02522933532111 6.47121686767e-19 1.50585723570184 5.75472154597638e-09 mirMAP -0.241690745210851 0.0101639313027127 NA NA NA hsa-miR-16-2-3p MME -0.615426607127207 4.13943192730969e-05 1.50585723570184 5.75472154597638e-09 MirTarget;mirMAP -0.160958905839054 0.0340437570093843 NA NA NA hsa-miR-186-5p MME -0.567811924899222 1.37607142180843e-13 1.50585723570184 5.75472154597638e-09 mirMAP -0.506217006010414 0.000426445002635839 NA NA NA hsa-miR-195-3p MME -0.598450619600341 1.01415597921415e-08 1.50585723570184 5.75472154597638e-09 MirTarget;mirMAP;miRNATAP -0.333332747294529 0.00168947462386571 NA NA NA hsa-miR-26b-5p MME -0.737437044119268 6.43607077094955e-18 1.50585723570184 5.75472154597638e-09 miRNAWalker2_validate;miRNATAP -0.379252328859179 0.00297480515553872 NA NA NA hsa-miR-30b-5p MME -1.16764575603669 1.75395013539893e-20 1.50585723570184 5.75472154597638e-09 mirMAP -0.218488149111957 0.0109420549159991 NA NA NA hsa-miR-30c-5p MME -0.746747513281496 1.32431877874928e-12 1.50585723570184 5.75472154597638e-09 mirMAP -0.234567154140582 0.0249352632494623 NA NA NA hsa-miR-30d-5p MME -0.804765144490435 1.42480384315577e-16 1.50585723570184 5.75472154597638e-09 mirMAP -0.221133902446437 0.0490808343332114 NA NA NA hsa-miR-361-5p MME -0.652200980992921 2.23302456529972e-21 1.50585723570184 5.75472154597638e-09 miRanda;mirMAP -0.383444458832257 0.0158524824679331 NA NA NA hsa-miR-409-3p MME 0.0985105482626563 0.373607618015637 1.50585723570184 5.75472154597638e-09 MirTarget -0.316200783457881 0.00183163274311777 NA NA NA hsa-miR-493-5p MME -0.327309705732346 0.0182120151854831 1.50585723570184 5.75472154597638e-09 MirTarget -0.275521802215593 0.000637475797366844 NA NA NA hsa-miR-539-5p MME -0.199350141954634 0.252691751194608 1.50585723570184 5.75472154597638e-09 mirMAP -0.274098641658305 3.07114786125697e-05 NA NA NA hsa-miR-582-3p MME -0.693858322916391 6.21181920447973e-07 1.50585723570184 5.75472154597638e-09 MirTarget -0.261193341517644 0.00103059531081355 NA NA NA hsa-miR-9-5p MME -1.13944963456975 4.52386797543032e-07 1.50585723570184 5.75472154597638e-09 MirTarget;miRNATAP -0.120507912886135 0.0139515869121548 NA NA NA hsa-miR-375 MORC3 -3.07641574130359 1.01411669962478e-67 0.47224959815518 1.94668115961985e-09 miRanda -0.121675203019843 1.74542660197512e-13 NA NA NA hsa-miR-106b-5p MPPED2 -1.03194006819592 5.97693261279532e-24 0.595249558424444 0.000225057781608441 mirMAP -0.403910522312408 2.87304301761367e-10 NA NA NA hsa-miR-126-5p MPPED2 -0.222731872217005 0.0500978215521652 0.595249558424444 0.000225057781608441 mirMAP -0.157045051352881 0.0101063252171111 NA NA NA hsa-miR-130b-3p MPPED2 -1.0141083264891 9.96856467852323e-16 0.595249558424444 0.000225057781608441 MirTarget -0.114006119122641 0.0328889170729436 NA NA NA hsa-miR-141-3p MPPED2 -1.79566520772936 2.43414267305203e-29 0.595249558424444 0.000225057781608441 TargetScan -0.202595429772274 6.33192972143966e-07 NA NA NA hsa-miR-148a-3p MPPED2 -1.85007671007711 2.47199960189669e-52 0.595249558424444 0.000225057781608441 MirTarget -0.21503053507 2.80874702904846e-05 NA NA NA hsa-miR-17-5p MPPED2 -1.75236465070226 3.95158641627966e-36 0.595249558424444 0.000225057781608441 mirMAP -0.320404965835453 1.71928149082739e-12 NA NA NA hsa-miR-18a-5p MPPED2 -1.25716708436839 5.1709808612863e-16 0.595249558424444 0.000225057781608441 mirMAP -0.140251967436596 0.00121876031727619 NA NA NA hsa-miR-192-5p MPPED2 -0.245629178320703 0.0371144833362325 0.595249558424444 0.000225057781608441 mirMAP -0.186724182568636 0.0014877560950017 NA NA NA hsa-miR-195-3p MPPED2 -0.598450619600341 1.01415597921415e-08 0.595249558424444 0.000225057781608441 MirTarget -0.203483309891775 0.00192914339635327 NA NA NA hsa-miR-19a-3p MPPED2 -1.31708679186777 4.80964007387792e-14 0.595249558424444 0.000225057781608441 MirTarget -0.167516939383671 1.29714660723267e-05 NA NA NA hsa-miR-19b-3p MPPED2 -1.59390221063917 1.21812878827867e-26 0.595249558424444 0.000225057781608441 MirTarget -0.196315425608514 7.69818901961605e-06 NA NA NA hsa-miR-20a-3p MPPED2 -1.93545996942606 5.86749215003329e-31 0.595249558424444 0.000225057781608441 mirMAP -0.245899344985713 1.52538892557529e-10 NA NA NA hsa-miR-20a-5p MPPED2 -1.8613782696103 3.92351368893149e-34 0.595249558424444 0.000225057781608441 mirMAP -0.291831774299785 2.42712980218668e-12 NA NA NA hsa-miR-25-3p MPPED2 -1.48824362562015 5.9514552944435e-55 0.595249558424444 0.000225057781608441 mirMAP -0.483464249877744 4.85045878157732e-14 NA NA NA hsa-miR-26b-3p MPPED2 -0.470600927165998 0.000240397864249736 0.595249558424444 0.000225057781608441 mirMAP -0.106866752243033 0.0474790104761601 NA NA NA hsa-miR-301a-3p MPPED2 -0.501721475120081 0.000262747397142621 0.595249558424444 0.000225057781608441 MirTarget -0.168535587194201 0.000770306818899482 NA NA NA hsa-miR-32-5p MPPED2 -0.919129456898536 9.58217908367915e-12 0.595249558424444 0.000225057781608441 mirMAP -0.383789639915047 5.68009033903302e-15 NA NA NA hsa-miR-320a MPPED2 -0.995486653328464 1.19389676663012e-20 0.595249558424444 0.000225057781608441 MirTarget;PITA;miRanda -0.174816420978734 0.00521804835658498 NA NA NA hsa-miR-335-5p MPPED2 -0.960193718665197 5.23061119483484e-12 0.595249558424444 0.000225057781608441 miRNAWalker2_validate -0.106386788991627 0.0293470615339809 NA NA NA hsa-miR-338-3p MPPED2 -0.289775600192434 0.0820821857540406 0.595249558424444 0.000225057781608441 miRanda -0.124578401754228 0.00266640186843612 NA NA NA hsa-miR-340-5p MPPED2 -0.418767158937088 8.44911569437027e-06 0.595249558424444 0.000225057781608441 mirMAP -0.155171246205937 0.0349403409798237 NA NA NA hsa-miR-342-3p MPPED2 -1.25856075011434 9.5039654565453e-34 0.595249558424444 0.000225057781608441 miRanda -0.175986139103971 0.00498255259107815 NA NA NA hsa-miR-429 MPPED2 -0.682420529994949 0.00462213397220848 0.595249558424444 0.000225057781608441 miRanda;miRNATAP -0.100569497047729 0.000429527377231244 NA NA NA hsa-miR-454-3p MPPED2 -1.05348676011504 1.08188735671628e-16 0.595249558424444 0.000225057781608441 MirTarget -0.262327292630465 6.15875195704995e-07 NA NA NA hsa-miR-590-3p MPPED2 -0.58484153433625 1.6489232844135e-06 0.595249558424444 0.000225057781608441 PITA;miRanda;mirMAP;miRNATAP -0.138669381147095 0.0140502503636787 NA NA NA hsa-miR-671-5p MPPED2 -1.21418487247953 1.04429628542981e-14 0.595249558424444 0.000225057781608441 miRNATAP -0.219847208944813 9.26506212944738e-07 NA NA NA hsa-miR-92a-3p MPPED2 -1.46190744133 3.47140194919109e-41 0.595249558424444 0.000225057781608441 mirMAP -0.414683798696375 7.32588265224616e-13 NA NA NA hsa-miR-93-3p MPPED2 -1.50606097047464 1.08346551902478e-22 0.595249558424444 0.000225057781608441 mirMAP -0.351846536218937 5.29275570685157e-17 NA NA NA hsa-miR-93-5p MPPED2 -2.02673564951393 4.11722430511061e-49 0.595249558424444 0.000225057781608441 mirMAP -0.346007400887325 1.01172205449531e-14 NA NA NA hsa-miR-375 MR1 -3.07641574130359 1.01411669962478e-67 1.24476104470398 8.73224884453594e-20 miRNAWalker2_validate -0.378569601512735 1.42038566833449e-42 NA NA NA hsa-miR-375 MREG -3.07641574130359 1.01411669962478e-67 0.746341064307269 2.50026083400687e-10 miRNAWalker2_validate -0.244959431237356 7.2487800944596e-24 NA NA NA hsa-miR-375 MST1R -3.07641574130359 1.01411669962478e-67 0.872906070173184 5.49252543397941e-07 miRanda -0.300522735536153 1.09401174556899e-16 27689991 However the function of miR-375 and RON expression in gastric cancer metastasis has not been sufficiently studied; Expression of miR-375 resulted in reduced activity of a luciferase reporter containing the 3'-UTR fragments of RON-encoding mRNA confirming that miR-375 directly targets the 3'-UTR of RON mRNA; Moreover we found that overexpression of miR-375 inhibited mRNA and protein expression of RON which was accompanied by the suppression of cell proliferation migration and invasion in gastric cancer AGS and MKN-28 cells; Thus our study provides evidence that miR-375 acts as a suppressor of metastasis in gastric cancer by targeting RON and might represent a new potential therapeutic target for gastric cancer metastasis gastric cancer hsa-miR-375 MSX2 -3.07641574130359 1.01411669962478e-67 0.820035320427197 9.68901103272404e-05 miRanda -0.15189302923982 0.000676425889214795 NA NA NA hsa-miR-375 MUC15 -3.07641574130359 1.01411669962478e-67 2.34222659116571 1.83688425221632e-13 MirTarget;miRanda -0.649676389436607 1.03367856847566e-22 NA NA NA hsa-miR-375 MYBL1 -3.07641574130359 1.01411669962478e-67 0.619056778297747 7.374176350211e-09 miRNAWalker2_validate -0.188021356272782 3.4323003762669e-17 NA NA NA hsa-miR-375 MYCBP2 -3.07641574130359 1.01411669962478e-67 0.570964122180752 6.44810778524446e-07 miRanda -0.127124152997217 1.644701848613e-07 NA NA NA hsa-miR-375 MYO16 -3.07641574130359 1.01411669962478e-67 0.86210217570643 7.8398788660179e-06 miRanda -0.273821023326049 1.25650369446833e-11 NA NA NA hsa-miR-127-5p MYO6 0.022773740645583 0.848974358202783 -0.898439165395941 9.74452532207278e-07 mirMAP -0.14158305438675 0.0331367683411981 NA NA NA hsa-miR-1287-5p MYO6 -0.0826219310802889 0.344777019974699 -0.898439165395941 9.74452532207278e-07 MirTarget -0.209468473640269 0.021761098972252 NA NA NA hsa-miR-143-3p MYO6 1.04476349103255 1.53710742335757e-21 -0.898439165395941 9.74452532207278e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.282860933933617 4.44864039963146e-05 20353999 A computational search indicated the 3'-untranslated region UTR of the mRNA for myosin VI MYO6 as a potential target for both miR-143 and miR-145 the expression of which was reduced in the tumor tissues; In luciferase reporter analysis we find a significant negative regulatory effect on the MYO6 3'UTR by both miR-143 and miR-145; Mutation of the potential binding sites for miR-143 and miR-145 in the MYO6 3'UTR resulted in a loss of responsiveness to the corresponding miRNA; Our data indicate that miR-143 and miR-145 are involved in the regulation of MYO6 expression and possibly in the development of prostate cancer prostate cancer hsa-miR-145-5p MYO6 0.0645550892386915 0.583308140519148 -0.898439165395941 9.74452532207278e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.431236064723871 8.27943404463796e-11 20353999 A computational search indicated the 3'-untranslated region UTR of the mRNA for myosin VI MYO6 as a potential target for both miR-143 and miR-145 the expression of which was reduced in the tumor tissues; In luciferase reporter analysis we find a significant negative regulatory effect on the MYO6 3'UTR by both miR-143 and miR-145; Mutation of the potential binding sites for miR-143 and miR-145 in the MYO6 3'UTR resulted in a loss of responsiveness to the corresponding miRNA; Our data indicate that miR-143 and miR-145 are involved in the regulation of MYO6 expression and possibly in the development of prostate cancer prostate cancer hsa-miR-155-5p MYO6 -0.657127495088523 1.32358745918864e-06 -0.898439165395941 9.74452532207278e-07 miRNAWalker2_validate -0.122176918420356 0.0345239933703799 NA NA NA hsa-miR-22-3p MYO6 -0.0702817991611031 0.331087165041124 -0.898439165395941 9.74452532207278e-07 miRNAWalker2_validate -0.366877633395858 0.000918278751324178 NA NA NA hsa-miR-23a-3p MYO6 0.403368902936407 3.67910482846993e-06 -0.898439165395941 9.74452532207278e-07 mirMAP -0.282088046567457 0.00184196715574686 NA NA NA hsa-miR-23b-3p MYO6 0.601466385152159 1.2679337399541e-12 -0.898439165395941 9.74452532207278e-07 mirMAP -0.393531293688575 1.73726885807736e-05 NA NA NA hsa-miR-26a-5p MYO6 0.255072671612547 2.10804942505379e-05 -0.898439165395941 9.74452532207278e-07 mirMAP -0.36652204973876 0.00608219299047492 NA NA NA hsa-miR-29a-5p MYO6 -0.458517912323331 0.000412683536074951 -0.898439165395941 9.74452532207278e-07 mirMAP -0.134066106906277 0.0274743004648355 NA NA NA hsa-miR-3065-5p MYO6 -1.04645334963496 3.19942342920484e-08 -0.898439165395941 9.74452532207278e-07 mirMAP -0.126077398747525 0.00254055576883368 NA NA NA hsa-miR-330-3p MYO6 0.648758240701829 1.73283773523948e-07 -0.898439165395941 9.74452532207278e-07 mirMAP -0.221215853575161 0.000506585153050135 NA NA NA hsa-miR-369-3p MYO6 0.519609525776978 0.000489324873973287 -0.898439165395941 9.74452532207278e-07 mirMAP -0.202279520271739 0.000124960075871644 NA NA NA hsa-miR-382-5p MYO6 -0.0267162333441817 0.815665757151437 -0.898439165395941 9.74452532207278e-07 mirMAP -0.137494471476644 0.0475963695773798 NA NA NA hsa-miR-409-3p MYO6 0.0985105482626563 0.373607618015637 -0.898439165395941 9.74452532207278e-07 mirMAP -0.15736512380148 0.0284489155040103 NA NA NA hsa-miR-450b-5p MYO6 0.857642158166269 2.78318878314148e-06 -0.898439165395941 9.74452532207278e-07 mirMAP -0.200729009236717 2.3830614396267e-06 NA NA NA hsa-miR-455-3p MYO6 0.279900062626516 0.0747679118573733 -0.898439165395941 9.74452532207278e-07 MirTarget;PITA;miRNATAP -0.104213542471622 0.0386840219399456 NA NA NA hsa-miR-455-5p MYO6 0.485855374388112 0.000213721591485799 -0.898439165395941 9.74452532207278e-07 miRanda -0.252017310057121 2.52198828329532e-05 NA NA NA hsa-miR-501-5p MYO6 -0.0408475609966014 0.781958453157052 -0.898439165395941 9.74452532207278e-07 mirMAP -0.148956791879727 0.00674664149731234 NA NA NA hsa-miR-542-3p MYO6 0.31864941892079 0.0301489241026756 -0.898439165395941 9.74452532207278e-07 miRanda -0.225322563572565 2.56212501129959e-05 NA NA NA hsa-miR-375 MYOZ2 -3.07641574130359 1.01411669962478e-67 1.6916013250438 3.56061218302832e-06 miRanda -0.533831594601994 2.9032816756303e-12 NA NA NA hsa-miR-375 NBEA -3.07641574130359 1.01411669962478e-67 0.52322426294506 1.87925492807395e-05 miRanda;miRNATAP -0.121375682920473 2.7183234625523e-06 NA NA NA hsa-miR-375 NBEAL1 -3.07641574130359 1.01411669962478e-67 0.703342762289109 0.000548521022059236 miRanda -0.192588381344376 7.5153704047094e-06 NA NA NA hsa-miR-375 NCAM1 -3.07641574130359 1.01411669962478e-67 2.12728585259509 2.15267158365083e-18 miRNAWalker2_validate;miRanda -0.667009037451067 6.57953259881576e-42 NA NA NA hsa-miR-375 NCOA7 -3.07641574130359 1.01411669962478e-67 0.627677875466678 0.000561889198502229 miRNAWalker2_validate;miRNATAP -0.268714635542137 1.37767413536192e-12 NA NA NA hsa-miR-28-5p NDRG2 -0.142043455520843 0.0231808012790841 1.2702817470867 3.05830633729702e-26 miRanda;miRNATAP -0.30767967832654 0.000416522197823197 NA NA NA hsa-miR-361-5p NDRG2 -0.652200980992921 2.23302456529972e-21 1.2702817470867 3.05830633729702e-26 miRanda -0.33562420017237 9.48340549053421e-06 NA NA NA hsa-miR-708-5p NDRG2 -1.92595740173581 2.59035129879776e-32 1.2702817470867 3.05830633729702e-26 miRNATAP -0.281165993770662 6.14778416520011e-21 NA NA NA hsa-miR-320a NELL2 -0.995486653328464 1.19389676663012e-20 1.12194526357047 8.99103045929715e-07 miRanda -0.227848541255172 0.0105393622571208 NA NA NA hsa-miR-320b NELL2 -0.588484324371412 9.31703617590323e-06 1.12194526357047 8.99103045929715e-07 miRanda -0.178039658647417 0.0159706279785626 NA NA NA hsa-miR-429 NELL2 -0.682420529994949 0.00462213397220848 1.12194526357047 8.99103045929715e-07 miRanda -0.197660030176933 1.00608421058493e-06 NA NA NA hsa-miR-484 NELL2 -0.968911692345789 2.45789986401529e-17 1.12194526357047 8.99103045929715e-07 miRNATAP -0.392216276779668 2.35677075051345e-06 NA NA NA hsa-miR-590-5p NELL2 -0.778106902153173 1.13576371947651e-09 1.12194526357047 8.99103045929715e-07 PITA;miRanda;miRNATAP -0.161268184865477 0.0340388427762262 NA NA NA hsa-miR-7-1-3p NELL2 -1.45703750327525 1.75378847810364e-30 1.12194526357047 8.99103045929715e-07 MirTarget -0.306434441116816 2.67441790743863e-05 NA NA NA hsa-miR-375 NKPD1 -3.07641574130359 1.01411669962478e-67 0.706943177564401 5.3102776098399e-08 miRanda -0.13144455899395 1.96283436397978e-06 NA NA NA hsa-miR-375 NLGN3 -3.07641574130359 1.01411669962478e-67 1.38218995951769 2.31946022972738e-17 miRanda -0.413925775112306 2.06121175023712e-35 NA NA NA hsa-miR-375 NOG -3.07641574130359 1.01411669962478e-67 1.24940239976626 3.4017492620634e-10 miRanda -0.455256217176643 3.43389872090081e-29 NA NA NA hsa-miR-375 NOVA1 -3.07641574130359 1.01411669962478e-67 0.704385044323654 5.50896432118446e-05 miRanda -0.305903704167974 2.45215591973489e-17 NA NA NA hsa-miR-139-3p NOX4 0.455337860982797 0.000454945209868944 -2.41169949678226 1.73056112145008e-21 MirTarget -0.613138756430914 4.38073928670477e-13 NA NA NA hsa-miR-144-5p NOX4 0.137749469177914 0.421335804923689 -2.41169949678226 1.73056112145008e-21 MirTarget -0.192493055603989 0.00338199020422914 NA NA NA hsa-miR-204-5p NOX4 1.00950273930716 9.21834560704585e-10 -2.41169949678226 1.73056112145008e-21 MirTarget -0.256315428043902 0.000128522971751127 NA NA NA hsa-miR-375 NPAS3 -3.07641574130359 1.01411669962478e-67 0.695992147183144 4.92413597882839e-06 miRanda -0.207407976714561 9.00659947133421e-11 NA NA NA hsa-miR-375 NPL -3.07641574130359 1.01411669962478e-67 0.317689768019126 0.0178866662086634 miRanda -0.227571633766988 1.85451655126584e-16 NA NA NA hsa-miR-375 NPY1R -3.07641574130359 1.01411669962478e-67 0.845140550509614 1.68381250996812e-09 miRanda -0.209241635965155 1.4240311830739e-12 NA NA NA hsa-miR-375 NR1H4 -3.07641574130359 1.01411669962478e-67 1.30936663432484 1.39113042716555e-05 miRanda -0.213662310977819 0.000865674844177993 NA NA NA hsa-miR-375 NR2F2 -3.07641574130359 1.01411669962478e-67 0.277624563171245 2.78841326392758e-05 miRanda -0.106114131287655 1.16552973362899e-14 NA NA NA hsa-miR-375 NRXN1 -3.07641574130359 1.01411669962478e-67 1.76867316913336 9.05246704997145e-13 miRanda -0.491659663006409 1.52429740935004e-21 NA NA NA hsa-let-7a-3p NTN4 -0.885792199222571 4.41035630133324e-17 1.26945935928603 6.44404468395437e-15 MirTarget -0.554506734874854 4.02961258233828e-18 NA NA NA hsa-let-7b-3p NTN4 -0.506893427781244 8.27914591468333e-08 1.26945935928603 6.44404468395437e-15 MirTarget -0.380173314733483 3.21067663635261e-07 NA NA NA hsa-let-7f-1-3p NTN4 -0.159920578752557 0.190200799823397 1.26945935928603 6.44404468395437e-15 MirTarget -0.156207838372728 0.00829012840275841 NA NA NA hsa-miR-106a-5p NTN4 -1.76751200862602 7.79031604495387e-24 1.26945935928603 6.44404468395437e-15 MirTarget;miRNATAP -0.322134283248473 1.32466064948225e-17 NA NA NA hsa-miR-106b-5p NTN4 -1.03194006819592 5.97693261279532e-24 1.26945935928603 6.44404468395437e-15 MirTarget;miRNATAP -0.630509089794639 1.24322099998736e-22 NA NA NA hsa-miR-140-5p NTN4 -0.714046975295031 8.18104415848501e-20 1.26945935928603 6.44404468395437e-15 MirTarget;miRanda -0.482912115639325 3.72685735784778e-08 NA NA NA hsa-miR-17-5p NTN4 -1.75236465070226 3.95158641627966e-36 1.26945935928603 6.44404468395437e-15 MirTarget;TargetScan;miRNATAP -0.543736288261435 7.59380934932684e-34 NA NA NA hsa-miR-182-5p NTN4 -2.57717136150549 4.94377928074908e-59 1.26945935928603 6.44404468395437e-15 miRNATAP -0.374044019292646 2.47492220561409e-22 NA NA NA hsa-miR-183-5p NTN4 -2.41864571314465 9.99562656802565e-54 1.26945935928603 6.44404468395437e-15 MirTarget -0.365506516976419 2.8858226904705e-20 NA NA NA hsa-miR-196b-5p NTN4 -0.805107318355036 4.71253050668845e-11 1.26945935928603 6.44404468395437e-15 MirTarget -0.380892628556285 1.42910052540415e-11 NA NA NA hsa-miR-20a-5p NTN4 -1.8613782696103 3.92351368893149e-34 1.26945935928603 6.44404468395437e-15 MirTarget;miRNATAP -0.464145095691358 4.97510887757742e-29 NA NA NA hsa-miR-20b-5p NTN4 -1.58314196476133 5.61327965534576e-17 1.26945935928603 6.44404468395437e-15 MirTarget;miRNATAP -0.289738951596621 4.05944709886354e-16 NA NA NA hsa-miR-26b-5p NTN4 -0.737437044119268 6.43607077094955e-18 1.26945935928603 6.44404468395437e-15 miRNATAP -0.639058395998469 7.85839993834075e-16 NA NA NA hsa-miR-29b-1-5p NTN4 -1.06520673410615 4.43912716822897e-11 1.26945935928603 6.44404468395437e-15 MirTarget -0.194942808153639 1.19006815721619e-05 NA NA NA hsa-miR-335-3p NTN4 -0.625191833097363 1.64208673352814e-06 1.26945935928603 6.44404468395437e-15 mirMAP -0.194422312443626 0.000330491374087603 NA NA NA hsa-miR-342-3p NTN4 -1.25856075011434 9.5039654565453e-34 1.26945935928603 6.44404468395437e-15 miRanda -0.352652167483292 3.51268806871437e-08 NA NA NA hsa-miR-362-3p NTN4 -0.332355427232084 0.0356765384646951 1.26945935928603 6.44404468395437e-15 miRanda -0.203436302099562 7.36778619983521e-06 NA NA NA hsa-miR-450b-5p NTN4 0.857642158166269 2.78318878314148e-06 1.26945935928603 6.44404468395437e-15 PITA;miRNATAP -0.166272836596426 1.53504842843609e-05 NA NA NA hsa-miR-493-5p NTN4 -0.327309705732346 0.0182120151854831 1.26945935928603 6.44404468395437e-15 MirTarget -0.148146833823808 0.00401676438789572 NA NA NA hsa-miR-590-3p NTN4 -0.58484153433625 1.6489232844135e-06 1.26945935928603 6.44404468395437e-15 miRanda -0.371888043000652 8.36229672212338e-11 NA NA NA hsa-miR-93-5p NTN4 -2.02673564951393 4.11722430511061e-49 1.26945935928603 6.44404468395437e-15 MirTarget;miRNATAP -0.552300418718827 7.16179391579748e-36 NA NA NA hsa-miR-96-5p NTN4 -2.57339472553563 5.77311209747623e-53 1.26945935928603 6.44404468395437e-15 MirTarget;TargetScan;miRNATAP -0.42482452516534 6.96424086233692e-32 NA NA NA hsa-miR-146a-5p NTNG2 -0.455337265499429 0.00460060887376666 0.851673544464155 1.51637601384607e-05 mirMAP -0.174708174123684 0.000866647951858441 NA NA NA hsa-miR-146b-5p NTNG2 -1.70281490248323 9.08060943822522e-35 0.851673544464155 1.51637601384607e-05 mirMAP -0.259003332004191 5.36233258713934e-06 NA NA NA hsa-miR-150-5p NTNG2 -0.563837387988475 0.000431936392596485 0.851673544464155 1.51637601384607e-05 mirMAP -0.156981558348685 0.00282306902308249 NA NA NA hsa-miR-375 NTRK3 -3.07641574130359 1.01411669962478e-67 1.35066616779791 8.24479518849741e-10 miRNATAP -0.361064308400612 5.18510327073815e-15 NA NA NA hsa-miR-375 NUDT7 -3.07641574130359 1.01411669962478e-67 0.519950836264937 8.57096135168626e-08 miRanda -0.123461444504283 1.71085467525566e-09 NA NA NA hsa-miR-126-5p OGN -0.222731872217005 0.0500978215521652 1.2799816844204 2.14305311526778e-09 mirMAP -0.282857143865613 0.000522746165701209 NA NA NA hsa-miR-142-3p OGN -0.668342567225765 0.000202408167795488 1.2799816844204 2.14305311526778e-09 miRanda -0.137933824849374 0.00708357886420316 NA NA NA hsa-miR-146b-5p OGN -1.70281490248323 9.08060943822522e-35 1.2799816844204 2.14305311526778e-09 miRanda -0.178894535292165 0.00430944662670682 NA NA NA hsa-miR-33a-3p OGN -0.612459021907227 0.000347410219059134 1.2799816844204 2.14305311526778e-09 mirMAP -0.421905642714178 4.16352426017867e-15 NA NA NA hsa-miR-340-5p OGN -0.418767158937088 8.44911569437027e-06 1.2799816844204 2.14305311526778e-09 mirMAP -0.511915727825344 1.50363521314516e-07 NA NA NA hsa-miR-361-5p OGN -0.652200980992921 2.23302456529972e-21 1.2799816844204 2.14305311526778e-09 miRanda;miRNATAP -0.474760300990331 0.000293020273943719 NA NA NA hsa-miR-429 OGN -0.682420529994949 0.00462213397220848 1.2799816844204 2.14305311526778e-09 miRanda -0.173288565098219 5.39210498032093e-06 NA NA NA hsa-miR-590-3p OGN -0.58484153433625 1.6489232844135e-06 1.2799816844204 2.14305311526778e-09 miRanda -0.490743342395725 4.00098335630996e-11 NA NA NA hsa-miR-375 OXR1 -3.07641574130359 1.01411669962478e-67 0.83143089714016 4.14636287942923e-18 miRanda -0.231537231401786 9.47005507004332e-32 NA NA NA hsa-miR-375 P2RX2 -3.07641574130359 1.01411669962478e-67 1.53320654367495 1.30621103408148e-08 miRanda -0.593947487216761 4.13830385289791e-27 NA NA NA hsa-miR-375 P2RX7 -3.07641574130359 1.01411669962478e-67 1.02573742678446 3.12627615541638e-07 miRanda -0.36414128290042 1.9176849206048e-18 NA NA NA hsa-miR-375 PAFAH1B2 -3.07641574130359 1.01411669962478e-67 0.593249924637147 1.73742363078693e-05 miRanda -0.13316069875131 5.27262926654828e-06 NA NA NA hsa-miR-375 PAK1 -3.07641574130359 1.01411669962478e-67 0.641826384679991 5.01403346790061e-10 miRanda -0.122141583188417 2.60197976384837e-08 NA NA NA hsa-miR-375 PAPSS2 -3.07641574130359 1.01411669962478e-67 0.218846309074904 0.17306268074322 miRanda -0.101498722351793 0.00279203126625731 NA NA NA hsa-miR-375 PAQR8 -3.07641574130359 1.01411669962478e-67 1.72974351953444 3.87552339528813e-27 miRNAWalker2_validate -0.561425488757792 4.78459502335505e-73 NA NA NA hsa-let-7a-5p PARM1 -0.810823676990507 1.01381033479519e-26 1.25031245879793 3.35722509988516e-19 MirTarget;TargetScan -0.638811111033973 4.36642200611517e-17 NA NA NA hsa-let-7b-5p PARM1 -0.221439854958536 0.00904814983284487 1.25031245879793 3.35722509988516e-19 MirTarget -0.231305734240623 0.00155768151310788 NA NA NA hsa-let-7d-5p PARM1 -0.767545769968654 1.765411565791e-19 1.25031245879793 3.35722509988516e-19 MirTarget -0.890094960675043 1.6848896014755e-42 NA NA NA hsa-let-7e-5p PARM1 -0.43840772282889 6.33224012337383e-08 1.25031245879793 3.35722509988516e-19 MirTarget -0.265753395999899 0.000450388445368079 NA NA NA hsa-let-7f-5p PARM1 -0.832261132545632 1.30765336262194e-16 1.25031245879793 3.35722509988516e-19 MirTarget -0.318793844115582 7.33152770706608e-08 NA NA NA hsa-let-7g-5p PARM1 -0.614367845078204 1.65972787509666e-17 1.25031245879793 3.35722509988516e-19 MirTarget -0.737491092611863 9.16259322412475e-20 NA NA NA hsa-let-7i-5p PARM1 -0.509810088463204 8.99644987043162e-12 1.25031245879793 3.35722509988516e-19 MirTarget -0.370358824700179 5.31223879493917e-06 NA NA NA hsa-miR-142-3p PARM1 -0.668342567225765 0.000202408167795488 1.25031245879793 3.35722509988516e-19 miRanda -0.173809216769493 2.73024640637536e-07 NA NA NA hsa-miR-16-2-3p PARM1 -0.615426607127207 4.13943192730969e-05 1.25031245879793 3.35722509988516e-19 mirMAP -0.280392578967497 8.41257603161296e-12 NA NA NA hsa-miR-182-5p PARM1 -2.57717136150549 4.94377928074908e-59 1.25031245879793 3.35722509988516e-19 MirTarget;miRNATAP -0.450152699512332 1.23938678022043e-45 NA NA NA hsa-miR-188-5p PARM1 -0.380696438407781 0.0146292832066358 1.25031245879793 3.35722509988516e-19 mirMAP -0.123857306961978 0.00207652725944878 NA NA NA hsa-miR-192-5p PARM1 -0.245629178320703 0.0371144833362325 1.25031245879793 3.35722509988516e-19 miRNAWalker2_validate;mirMAP -0.343163123867904 2.88180463860542e-11 NA NA NA hsa-miR-195-3p PARM1 -0.598450619600341 1.01415597921415e-08 1.25031245879793 3.35722509988516e-19 mirMAP -0.250472839795862 1.71493804835932e-05 NA NA NA hsa-miR-19a-3p PARM1 -1.31708679186777 4.80964007387792e-14 1.25031245879793 3.35722509988516e-19 miRNATAP -0.293211237699445 1.48580611670019e-18 NA NA NA hsa-miR-19b-3p PARM1 -1.59390221063917 1.21812878827867e-26 1.25031245879793 3.35722509988516e-19 miRNATAP -0.383972453960098 2.12299038447708e-24 NA NA NA hsa-miR-200c-5p PARM1 -1.26212096144975 2.32216419703764e-18 1.25031245879793 3.35722509988516e-19 MirTarget;miRNATAP -0.241602784912984 3.28481068067138e-09 NA NA NA hsa-miR-26b-5p PARM1 -0.737437044119268 6.43607077094955e-18 1.25031245879793 3.35722509988516e-19 mirMAP -0.482868533537135 2.74674377320975e-12 NA NA NA hsa-miR-3065-5p PARM1 -1.04645334963496 3.19942342920484e-08 1.25031245879793 3.35722509988516e-19 miRNATAP -0.113816320448271 0.000469395260940561 NA NA NA hsa-miR-30d-3p PARM1 -0.917692758870647 7.72239658481192e-16 1.25031245879793 3.35722509988516e-19 mirMAP -0.363388012827776 2.36963514719058e-12 NA NA NA hsa-miR-324-5p PARM1 -0.539970285576229 1.69955273262756e-05 1.25031245879793 3.35722509988516e-19 miRNAWalker2_validate -0.171217356506195 0.000447571137128046 NA NA NA hsa-miR-335-3p PARM1 -0.625191833097363 1.64208673352814e-06 1.25031245879793 3.35722509988516e-19 mirMAP -0.414927225816802 5.61645970851494e-20 NA NA NA hsa-miR-340-5p PARM1 -0.418767158937088 8.44911569437027e-06 1.25031245879793 3.35722509988516e-19 mirMAP -0.232984543022331 0.000362945666477819 NA NA NA hsa-miR-3607-3p PARM1 -1.16606393006353 2.28951370382029e-07 1.25031245879793 3.35722509988516e-19 mirMAP -0.151995237252793 1.29070985810158e-08 NA NA NA hsa-miR-590-3p PARM1 -0.58484153433625 1.6489232844135e-06 1.25031245879793 3.35722509988516e-19 miRanda -0.307556823348516 5.59452584053766e-10 NA NA NA hsa-miR-671-5p PARM1 -1.21418487247953 1.04429628542981e-14 1.25031245879793 3.35722509988516e-19 MirTarget -0.306952906915078 5.50335855473971e-15 NA NA NA hsa-miR-7-1-3p PARM1 -1.45703750327525 1.75378847810364e-30 1.25031245879793 3.35722509988516e-19 mirMAP -0.387533241706068 3.27715536422128e-18 NA NA NA hsa-miR-769-5p PARM1 -0.496725395031541 5.04386163179333e-07 1.25031245879793 3.35722509988516e-19 miRNATAP -0.393681437588453 1.19707949608146e-10 NA NA NA hsa-miR-98-5p PARM1 -0.285702607800677 7.70620719768814e-06 1.25031245879793 3.35722509988516e-19 MirTarget -0.557523317202475 7.2175238574727e-09 NA NA NA hsa-miR-375 PARP15 -3.07641574130359 1.01411669962478e-67 -0.123950362110809 0.573896886686962 miRanda -0.134454651364676 0.00389440833304036 NA NA NA hsa-miR-375 PBXIP1 -3.07641574130359 1.01411669962478e-67 0.396819038137753 4.0552164287277e-09 miRNAWalker2_validate -0.119597431947545 1.48828146390187e-17 NA NA NA hsa-miR-375 PCDH11X -3.07641574130359 1.01411669962478e-67 1.64018723982428 1.00032700351252e-11 miRanda -0.48150790969593 6.61610120765055e-22 NA NA NA hsa-miR-375 PCDH18 -3.07641574130359 1.01411669962478e-67 1.03164823058405 2.99527753618541e-10 miRanda -0.350567751564095 2.18474288142019e-25 NA NA NA hsa-miR-375 PCDH20 -3.07641574130359 1.01411669962478e-67 1.14351245294256 7.41245270822897e-08 miRanda -0.261101913414039 6.4040960662094e-09 NA NA NA hsa-miR-141-3p PCDH9 -1.79566520772936 2.43414267305203e-29 1.7009589947683 9.82779889298087e-19 MirTarget;miRNATAP -0.526671442162489 3.51009412521124e-28 NA NA NA hsa-miR-146b-5p PCDH9 -1.70281490248323 9.08060943822522e-35 1.7009589947683 9.82779889298087e-19 miRanda -0.257909486534154 6.46224443757364e-06 NA NA NA hsa-miR-15a-5p PCDH9 -0.922713188178759 6.51407511505147e-18 1.7009589947683 9.82779889298087e-19 MirTarget;miRNATAP -0.428653021845666 1.98174122634065e-08 NA NA NA hsa-miR-15b-5p PCDH9 -0.902378373341059 1.52338978476144e-20 1.7009589947683 9.82779889298087e-19 MirTarget;miRNATAP -0.700974743605403 1.57412996913429e-17 NA NA NA hsa-miR-16-5p PCDH9 -0.547308885680377 1.14657883125977e-10 1.7009589947683 9.82779889298087e-19 MirTarget;miRNATAP -0.308578975145478 0.00184179438459747 NA NA NA hsa-miR-188-5p PCDH9 -0.380696438407781 0.0146292832066358 1.7009589947683 9.82779889298087e-19 MirTarget;PITA;miRNATAP -0.149527896737182 0.0070399079835868 NA NA NA hsa-miR-192-5p PCDH9 -0.245629178320703 0.0371144833362325 1.7009589947683 9.82779889298087e-19 MirTarget -0.227863996704986 0.00159946230178759 NA NA NA hsa-miR-26b-5p PCDH9 -0.737437044119268 6.43607077094955e-18 1.7009589947683 9.82779889298087e-19 MirTarget;miRNATAP -0.599923796866786 3.48244872464712e-10 NA NA NA hsa-miR-3065-5p PCDH9 -1.04645334963496 3.19942342920484e-08 1.7009589947683 9.82779889298087e-19 MirTarget;miRNATAP -0.121072992633844 0.00705967206350718 NA NA NA hsa-miR-30a-5p PCDH9 -0.508562243919922 3.02321261664392e-06 1.7009589947683 9.82779889298087e-19 MirTarget -0.262575019678338 0.000705692511156675 NA NA NA hsa-miR-30b-5p PCDH9 -1.16764575603669 1.75395013539893e-20 1.7009589947683 9.82779889298087e-19 MirTarget -0.557759307092975 9.69679098078568e-19 NA NA NA hsa-miR-30c-5p PCDH9 -0.746747513281496 1.32431877874928e-12 1.7009589947683 9.82779889298087e-19 MirTarget -0.394851110416785 5.22750998558623e-07 NA NA NA hsa-miR-30d-5p PCDH9 -0.804765144490435 1.42480384315577e-16 1.7009589947683 9.82779889298087e-19 MirTarget -0.564198675611442 1.58729846042364e-11 NA NA NA hsa-miR-32-5p PCDH9 -0.919129456898536 9.58217908367915e-12 1.7009589947683 9.82779889298087e-19 miRNATAP -0.526297662968857 1.58796735342824e-18 NA NA NA hsa-miR-335-3p PCDH9 -0.625191833097363 1.64208673352814e-06 1.7009589947683 9.82779889298087e-19 mirMAP -0.244690732073877 0.000147372869877325 NA NA NA hsa-miR-335-5p PCDH9 -0.960193718665197 5.23061119483484e-12 1.7009589947683 9.82779889298087e-19 MirTarget;miRNATAP -0.215402280571754 0.000312351160769079 NA NA NA hsa-miR-361-5p PCDH9 -0.652200980992921 2.23302456529972e-21 1.7009589947683 9.82779889298087e-19 PITA;miRanda;miRNATAP -0.495648226728791 3.6563773498213e-05 NA NA NA hsa-miR-497-5p PCDH9 -0.424937624679997 8.43432731476464e-05 1.7009589947683 9.82779889298087e-19 MirTarget;miRNATAP -0.182033995900501 0.020517347517792 NA NA NA hsa-miR-501-3p PCDH9 -1.44481364651779 3.8180974374837e-26 1.7009589947683 9.82779889298087e-19 MirTarget;PITA;miRNATAP -0.312016301382997 1.15579549054271e-07 NA NA NA hsa-miR-532-5p PCDH9 -0.819279743754759 7.8621216315329e-15 1.7009589947683 9.82779889298087e-19 MirTarget;PITA;miRNATAP -0.397015180937593 3.8369788086914e-07 NA NA NA hsa-miR-582-3p PCDH9 -0.693858322916391 6.21181920447973e-07 1.7009589947683 9.82779889298087e-19 miRNATAP -0.206979021062828 0.000610095267644663 NA NA NA hsa-miR-590-3p PCDH9 -0.58484153433625 1.6489232844135e-06 1.7009589947683 9.82779889298087e-19 PITA;miRanda;mirMAP -0.35416519623328 2.54158140179956e-07 NA NA NA hsa-miR-660-5p PCDH9 -1.14400353328339 2.69534153134488e-19 1.7009589947683 9.82779889298087e-19 MirTarget;miRNATAP -0.33464048551137 1.66953698146639e-07 NA NA NA hsa-miR-7-1-3p PCDH9 -1.45703750327525 1.75378847810364e-30 1.7009589947683 9.82779889298087e-19 MirTarget;mirMAP -0.593905170053893 1.62169670963631e-22 NA NA NA hsa-miR-92a-3p PCDH9 -1.46190744133 3.47140194919109e-41 1.7009589947683 9.82779889298087e-19 miRNATAP -0.723187113587772 1.44564044321786e-25 NA NA NA hsa-miR-375 PCGF5 -3.07641574130359 1.01411669962478e-67 0.564423414903136 1.80986245778029e-15 miRNAWalker2_validate -0.133394441085344 3.45413734571197e-19 NA NA NA hsa-miR-375 PCSK5 -3.07641574130359 1.01411669962478e-67 0.595453444671759 0.000158534817260037 miRanda -0.264980105056271 4.82363736888198e-16 NA NA NA hsa-miR-375 PCYT1B -3.07641574130359 1.01411669962478e-67 1.81668862285027 2.80840618905409e-16 mirMAP -0.581230694936687 4.53705692916834e-38 NA NA NA hsa-miR-375 PDE4A -3.07641574130359 1.01411669962478e-67 1.1179585916866 4.12271979623027e-17 miRanda -0.318109224145199 3.39822115972533e-31 NA NA NA hsa-miR-375 PDE4D -3.07641574130359 1.01411669962478e-67 0.816328744742632 7.06125382987686e-14 miRNATAP -0.200322195194771 2.1118226908503e-18 NA NA NA hsa-miR-375 PDE5A -3.07641574130359 1.01411669962478e-67 1.28973048761232 2.25569896940602e-12 miRanda;miRNATAP -0.46521522317289 5.54828354870731e-36 NA NA NA hsa-miR-375 PDE8B -3.07641574130359 1.01411669962478e-67 0.805187334691794 0.000437103859067283 miRanda -0.146405238345432 0.00261064357190221 NA NA NA hsa-miR-375 PDGFC -3.07641574130359 1.01411669962478e-67 1.15021236015167 4.31158896023614e-16 miRNAWalker2_validate;miRanda -0.374107228739245 5.20583468713192e-39 NA NA NA hsa-miR-103a-3p PDK4 -1.20954748107199 5.62173682108288e-44 2.10433479384504 6.14548388074473e-20 miRNAWalker2_validate;MirTarget -0.825845829463559 5.94727819868628e-15 NA NA NA hsa-miR-142-3p PDK4 -0.668342567225765 0.000202408167795488 2.10433479384504 6.14548388074473e-20 miRanda -0.291125226102622 1.84674148853521e-07 NA NA NA hsa-miR-146b-5p PDK4 -1.70281490248323 9.08060943822522e-35 2.10433479384504 6.14548388074473e-20 miRanda -0.569039566708056 1.92685909300906e-17 NA NA NA hsa-miR-148a-3p PDK4 -1.85007671007711 2.47199960189669e-52 2.10433479384504 6.14548388074473e-20 miRNATAP -0.619190614022775 4.96068638092809e-17 NA NA NA hsa-miR-148a-5p PDK4 -1.02522933532111 6.47121686767e-19 2.10433479384504 6.14548388074473e-20 mirMAP -0.45738150056577 6.71809017449921e-08 NA NA NA hsa-miR-148b-3p PDK4 -0.551634584599407 1.25985630163353e-10 2.10433479384504 6.14548388074473e-20 miRNATAP -0.532154353568325 5.39462667643695e-06 NA NA NA hsa-miR-15a-5p PDK4 -0.922713188178759 6.51407511505147e-18 2.10433479384504 6.14548388074473e-20 MirTarget;miRNATAP -0.345135159580643 0.000184244207536053 NA NA NA hsa-miR-15b-5p PDK4 -0.902378373341059 1.52338978476144e-20 2.10433479384504 6.14548388074473e-20 MirTarget;miRNATAP -0.97975644941931 8.11710548172303e-24 NA NA NA hsa-miR-16-5p PDK4 -0.547308885680377 1.14657883125977e-10 2.10433479384504 6.14548388074473e-20 miRNAWalker2_validate;MirTarget;miRNATAP -0.43444297627516 0.000248740128473863 NA NA NA hsa-miR-186-5p PDK4 -0.567811924899222 1.37607142180843e-13 2.10433479384504 6.14548388074473e-20 mirMAP -0.785090763322866 1.28098584598324e-09 NA NA NA hsa-miR-26b-5p PDK4 -0.737437044119268 6.43607077094955e-18 2.10433479384504 6.14548388074473e-20 miRNAWalker2_validate -0.592819841760614 2.72163668373839e-07 NA NA NA hsa-miR-28-5p PDK4 -0.142043455520843 0.0231808012790841 2.10433479384504 6.14548388074473e-20 miRanda -0.539522422901581 0.00111715122890373 NA NA NA hsa-miR-30d-3p PDK4 -0.917692758870647 7.72239658481192e-16 2.10433479384504 6.14548388074473e-20 MirTarget -0.536209178855779 4.59026293445116e-10 NA NA NA hsa-miR-335-5p PDK4 -0.960193718665197 5.23061119483484e-12 2.10433479384504 6.14548388074473e-20 miRNAWalker2_validate -0.306325802118797 1.81714052537143e-05 NA NA NA hsa-miR-361-5p PDK4 -0.652200980992921 2.23302456529972e-21 2.10433479384504 6.14548388074473e-20 miRanda;miRNATAP -0.550489582116507 0.000133577072099954 NA NA NA hsa-miR-491-5p PDK4 -0.996821208926168 6.43686029153545e-11 2.10433479384504 6.14548388074473e-20 MirTarget;miRanda -0.3474297096197 1.04052679568944e-07 NA NA NA hsa-miR-493-5p PDK4 -0.327309705732346 0.0182120151854831 2.10433479384504 6.14548388074473e-20 MirTarget -0.221246690965009 0.00262100283246003 NA NA NA hsa-miR-497-5p PDK4 -0.424937624679997 8.43432731476464e-05 2.10433479384504 6.14548388074473e-20 MirTarget;miRNATAP -0.22540773860937 0.0167076731766018 NA NA NA hsa-miR-532-5p PDK4 -0.819279743754759 7.8621216315329e-15 2.10433479384504 6.14548388074473e-20 MirTarget -0.60333202929864 9.01659697968015e-11 NA NA NA hsa-miR-576-5p PDK4 -0.962105441345164 5.68435745070752e-14 2.10433479384504 6.14548388074473e-20 mirMAP -0.565617139355946 1.1106837809125e-13 NA NA NA hsa-miR-590-3p PDK4 -0.58484153433625 1.6489232844135e-06 2.10433479384504 6.14548388074473e-20 miRanda -0.455526631988528 3.02472517831092e-08 NA NA NA hsa-miR-664a-3p PDK4 -0.771665734879283 3.09460128204882e-14 2.10433479384504 6.14548388074473e-20 mirMAP -0.430748988798744 1.05092051084685e-05 NA NA NA hsa-miR-942-5p PDK4 -0.379108527613044 0.00732116056229795 2.10433479384504 6.14548388074473e-20 MirTarget -0.205866489437255 0.00464834872035011 NA NA NA hsa-miR-375 PDZD8 -3.07641574130359 1.01411669962478e-67 0.624767919552057 5.48393864325389e-06 miRanda -0.195574415173455 1.12003004066919e-11 NA NA NA hsa-miR-34c-5p PEBP4 -0.411316782408141 0.0146968432653683 0.572065869705389 0.0965975733798051 miRanda -0.347828258233332 6.43536096769113e-05 NA NA NA hsa-miR-375 PEG10 -3.07641574130359 1.01411669962478e-67 1.83181903452311 2.3149558064033e-14 mirMAP -0.488010808171573 1.9139358526247e-22 NA NA NA hsa-miR-375 PHLDA1 -3.07641574130359 1.01411669962478e-67 1.08940958148131 1.66233926444389e-13 miRNAWalker2_validate;miRNATAP -0.312581074439899 1.88551999227687e-24 NA NA NA hsa-miR-375 PHTF2 -3.07641574130359 1.01411669962478e-67 0.409304235711789 7.51847656995923e-08 miRNAWalker2_validate -0.128139841358507 6.01564365307251e-16 NA NA NA hsa-miR-375 PHYHIPL -3.07641574130359 1.01411669962478e-67 1.91392590767475 1.31497965982275e-22 miRanda -0.389695448987962 7.88791590154919e-21 NA NA NA hsa-miR-375 PIAS1 -3.07641574130359 1.01411669962478e-67 0.725479417917228 2.49026605435e-15 miRanda -0.1933432421128 3.67753898772701e-24 NA NA NA hsa-miR-375 PIK3IP1 -3.07641574130359 1.01411669962478e-67 0.276367773582804 0.00112233321854472 miRNAWalker2_validate -0.139704904617274 1.61917164557578e-15 NA NA NA hsa-miR-375 PIPOX -3.07641574130359 1.01411669962478e-67 1.67156207824133 3.07675309372683e-21 miRanda;miRNATAP -0.45345762325074 1.21396949158644e-35 NA NA NA hsa-miR-375 PLAG1 -3.07641574130359 1.01411669962478e-67 1.73208088248879 3.67013186133856e-25 miRNAWalker2_validate;miRTarBase;mirMAP -0.459323799856764 8.38784812966878e-41 NA NA NA hsa-miR-375 PLCH1 -3.07641574130359 1.01411669962478e-67 0.792226969562632 0.000204887412160691 miRanda -0.350962419981612 2.17845903247824e-15 NA NA NA hsa-miR-375 PLD5 -3.07641574130359 1.01411669962478e-67 1.55857529830733 7.53178385296033e-08 miRanda -0.437253270862739 6.61952056640636e-13 NA NA NA hsa-miR-375 PLSCR1 -3.07641574130359 1.01411669962478e-67 0.462601657705444 0.00037981636596701 miRanda -0.236176125688672 1.18951121373437e-18 NA NA NA hsa-miR-375 PLXNA4 -3.07641574130359 1.01411669962478e-67 1.06253993444213 3.55866160663945e-09 miRNATAP -0.425691910794897 1.77247024388378e-31 NA NA NA hsa-miR-375 PNMA2 -3.07641574130359 1.01411669962478e-67 1.35516731238715 2.03585829465155e-11 miRanda -0.441312055771222 2.63918518596751e-26 NA NA NA hsa-miR-139-5p POSTN 0.248477989074289 0.0406493945332509 -0.428368545601547 0.0155578239622661 miRanda -0.160906524761434 0.0100157219553531 NA NA NA hsa-miR-375 POU3F1 -3.07641574130359 1.01411669962478e-67 1.8473155531386 2.75774502342094e-22 MirTarget;miRanda -0.441833191593937 1.36242952316162e-28 NA NA NA hsa-miR-375 PPARGC1A -3.07641574130359 1.01411669962478e-67 2.27652974976557 7.73652880860929e-27 miRanda -0.581392674699969 3.53037399697512e-40 NA NA NA hsa-miR-375 PPARGC1B -3.07641574130359 1.01411669962478e-67 1.54762864090496 1.57266010521574e-18 miRNATAP -0.479018493118706 4.63414457204809e-41 NA NA NA hsa-miR-217 PPM1E -0.647926571365963 0.000615546232893747 -1.59626478868764 7.25878632131682e-14 MirTarget;PITA;miRanda -0.131456188973065 0.00743461554440453 NA NA NA hsa-miR-29b-3p PPM1E -0.305845215326375 0.00477759838414869 -1.59626478868764 7.25878632131682e-14 MirTarget -0.19026757728758 0.0274531752282811 NA NA NA hsa-miR-330-3p PPM1E 0.648758240701829 1.73283773523948e-07 -1.59626478868764 7.25878632131682e-14 PITA -0.186970338968681 0.0129754697878427 NA NA NA hsa-miR-375 PPP1R12B -3.07641574130359 1.01411669962478e-67 1.32949916920023 3.21491172562241e-20 miRanda -0.436337771030671 3.28756967445299e-52 NA NA NA hsa-miR-152-3p PPP1R9A 0.61921798235936 2.45752840902353e-13 -0.791094597894397 2.85701184446502e-16 MirTarget -0.160849400098638 0.00112496456238389 NA NA NA hsa-miR-181a-5p PPP1R9A -0.345696423622306 0.000458417065949032 -0.791094597894397 2.85701184446502e-16 miRNAWalker2_validate -0.17015400845001 7.32867162848682e-05 NA NA NA hsa-miR-199a-3p PPP1R9A 0.0553473600849195 0.587002550685305 -0.791094597894397 2.85701184446502e-16 MirTarget;PITA;miRNATAP -0.140525131867031 0.000783320543154777 NA NA NA hsa-miR-199a-5p PPP1R9A -0.56859326149571 4.98517644263078e-07 -0.791094597894397 2.85701184446502e-16 MirTarget;PITA;miRanda;miRNATAP -0.124431715078272 0.000824637571312507 NA NA NA hsa-miR-199b-3p PPP1R9A 0.0592501088066051 0.561598445904767 -0.791094597894397 2.85701184446502e-16 MirTarget;PITA;miRNATAP -0.139370800303857 0.000847453056651379 NA NA NA hsa-miR-26a-5p PPP1R9A 0.255072671612547 2.10804942505379e-05 -0.791094597894397 2.85701184446502e-16 mirMAP -0.341133150819607 1.67499017134036e-06 NA NA NA hsa-miR-30c-5p PPP1R9A -0.746747513281496 1.32431877874928e-12 -0.791094597894397 2.85701184446502e-16 MirTarget;mirMAP;miRNATAP -0.121427606531002 0.00215875357199448 NA NA NA hsa-miR-338-5p PPP1R9A 1.0222700595457 1.2342974008659e-09 -0.791094597894397 2.85701184446502e-16 mirMAP;miRNATAP -0.110690456131461 8.70570727080896e-06 NA NA NA hsa-miR-376c-3p PPP1R9A 0.121213663149106 0.383377107417723 -0.791094597894397 2.85701184446502e-16 mirMAP -0.173596376685508 1.41017886920362e-08 NA NA NA hsa-miR-381-3p PPP1R9A 0.64993607209338 4.37359495040895e-09 -0.791094597894397 2.85701184446502e-16 mirMAP -0.133816421777358 0.000404793281481498 NA NA NA hsa-miR-500a-5p PPP1R9A -0.724031963091637 1.07520204401534e-07 -0.791094597894397 2.85701184446502e-16 mirMAP -0.105234860706532 0.000651126067604851 NA NA NA hsa-miR-375 PPP2R3A -3.07641574130359 1.01411669962478e-67 0.622177172667679 2.57266149227204e-15 miRanda -0.144749925231735 2.14798757957767e-18 NA NA NA hsa-miR-375 PRDM16 -3.07641574130359 1.01411669962478e-67 1.14164637435729 1.00340969163801e-11 miRNATAP -0.504744133493433 8.32137565343671e-54 NA NA NA hsa-miR-1180-3p PRIMA1 -0.0731693185509816 0.528791502847713 1.67094149943873 1.60525208708533e-15 MirTarget -0.259832182444075 0.00106611423251915 NA NA NA hsa-miR-1266-5p PRIMA1 -0.973179154209445 2.14755153773861e-10 1.67094149943873 1.60525208708533e-15 MirTarget -0.274617532781887 3.17480697319268e-06 NA NA NA hsa-miR-15a-5p PRIMA1 -0.922713188178759 6.51407511505147e-18 1.67094149943873 1.60525208708533e-15 mirMAP -0.43385921367846 1.60869516563863e-07 NA NA NA hsa-miR-19b-1-5p PRIMA1 -1.2422681534557 6.28223951411771e-20 1.67094149943873 1.60525208708533e-15 mirMAP -0.511107926304422 9.94698866959946e-16 NA NA NA hsa-miR-335-3p PRIMA1 -0.625191833097363 1.64208673352814e-06 1.67094149943873 1.60525208708533e-15 mirMAP -0.420682997850452 1.11854927206198e-09 NA NA NA hsa-miR-335-5p PRIMA1 -0.960193718665197 5.23061119483484e-12 1.67094149943873 1.60525208708533e-15 mirMAP -0.222426017358731 0.000587685070466116 NA NA NA hsa-miR-33a-5p PRIMA1 0.0191758999894391 0.924819190352805 1.67094149943873 1.60525208708533e-15 mirMAP -0.240341210536869 8.29732369481841e-08 NA NA NA hsa-miR-342-3p PRIMA1 -1.25856075011434 9.5039654565453e-34 1.67094149943873 1.60525208708533e-15 miRanda -0.404817223890327 9.86942532856276e-07 NA NA NA hsa-miR-361-5p PRIMA1 -0.652200980992921 2.23302456529972e-21 1.67094149943873 1.60525208708533e-15 mirMAP -0.313842257017437 0.0162801483405256 NA NA NA hsa-miR-3913-5p PRIMA1 -0.36017362814041 0.00428147059781048 1.67094149943873 1.60525208708533e-15 mirMAP -0.232498825854441 0.00149610517061521 NA NA NA hsa-miR-491-5p PRIMA1 -0.996821208926168 6.43686029153545e-11 1.67094149943873 1.60525208708533e-15 MirTarget;miRanda -0.390732442927852 2.45135454108846e-11 NA NA NA hsa-miR-590-5p PRIMA1 -0.778106902153173 1.13576371947651e-09 1.67094149943873 1.60525208708533e-15 miRanda -0.547480268111636 2.67180829198783e-15 NA NA NA hsa-miR-93-3p PRIMA1 -1.50606097047464 1.08346551902478e-22 1.67094149943873 1.60525208708533e-15 MirTarget -0.634657874983135 1.09177285669015e-31 NA NA NA hsa-miR-96-5p PRIMA1 -2.57339472553563 5.77311209747623e-53 1.67094149943873 1.60525208708533e-15 MirTarget;TargetScan;miRNATAP -0.629569011920923 1.88427067690579e-43 NA NA NA hsa-miR-375 PRKCA -3.07641574130359 1.01411669962478e-67 1.25886235428745 1.47687302700283e-18 miRNAWalker2_validate -0.336258624085311 9.01320259203412e-30 NA NA NA hsa-miR-375 PROCR -3.07641574130359 1.01411669962478e-67 0.648240198879069 7.8195466007052e-09 miRNAWalker2_validate -0.19007585777562 5.26615583936828e-16 NA NA NA hsa-miR-125a-3p PRR16 0.335450161542356 0.00400908432417963 -2.0306955008957 6.19700664260041e-16 miRanda -0.320669294285363 0.000831861982651149 NA NA NA hsa-miR-27a-3p PRR16 0.422972805377022 8.01035506212495e-07 -2.0306955008957 6.19700664260041e-16 MirTarget -0.346898537692512 0.00693393697324647 NA NA NA hsa-miR-27b-3p PRR16 0.671557822127916 5.00469777243463e-17 -2.0306955008957 6.19700664260041e-16 MirTarget -0.864376690053645 7.38861635603456e-11 NA NA NA hsa-miR-374a-5p PRR16 0.0315285733368933 0.724846989131115 -2.0306955008957 6.19700664260041e-16 MirTarget -0.272198312573006 0.028588223202951 NA NA NA hsa-miR-374b-5p PRR16 -0.221226738167835 0.00747242957932152 -2.0306955008957 6.19700664260041e-16 MirTarget -0.479387927658602 0.000346534495240939 NA NA NA hsa-miR-542-3p PRR16 0.31864941892079 0.0301489241026756 -2.0306955008957 6.19700664260041e-16 miRanda -0.349279856625057 2.7798970614136e-06 NA NA NA hsa-miR-375 PSIP1 -3.07641574130359 1.01411669962478e-67 0.710982495360549 5.1029548811329e-24 miRNAWalker2_validate;miRanda -0.20332978845497 2.55790823083922e-46 NA NA NA hsa-let-7a-5p PTGS1 -0.810823676990507 1.01381033479519e-26 2.09881864648574 3.79641738869551e-26 miRNAWalker2_validate -1.12382655489478 1.86231912925294e-25 NA NA NA hsa-let-7b-5p PTGS1 -0.221439854958536 0.00904814983284487 2.09881864648574 3.79641738869551e-26 miRNAWalker2_validate -0.504823119568862 1.45592814896712e-06 NA NA NA hsa-miR-10b-3p PTGS1 -0.178306123800735 0.208972787972894 2.09881864648574 3.79641738869551e-26 mirMAP -0.373494001453811 1.64704006501746e-09 NA NA NA hsa-miR-1301-3p PTGS1 -1.04723166514282 1.08006888220124e-14 2.09881864648574 3.79641738869551e-26 miRNAWalker2_validate -0.374408138574951 3.25081238994506e-09 NA NA NA hsa-miR-146b-5p PTGS1 -1.70281490248323 9.08060943822522e-35 2.09881864648574 3.79641738869551e-26 miRNAWalker2_validate -0.131920832044535 0.028599587861542 NA NA NA hsa-miR-149-5p PTGS1 -0.653969866006385 3.97144325806485e-05 2.09881864648574 3.79641738869551e-26 miRNAWalker2_validate -0.233041660569403 2.48627692766521e-05 NA NA NA hsa-miR-16-5p PTGS1 -0.547308885680377 1.14657883125977e-10 2.09881864648574 3.79641738869551e-26 miRNAWalker2_validate -0.700286918678824 6.39679091756301e-12 NA NA NA hsa-miR-186-5p PTGS1 -0.567811924899222 1.37607142180843e-13 2.09881864648574 3.79641738869551e-26 miRNAWalker2_validate -0.650893517049579 8.63768045247224e-09 NA NA NA hsa-miR-193b-3p PTGS1 -0.425830265253153 0.00142308830221877 2.09881864648574 3.79641738869551e-26 miRNAWalker2_validate -0.13597360204818 0.0412099558716625 NA NA NA hsa-miR-196b-5p PTGS1 -0.805107318355036 4.71253050668845e-11 2.09881864648574 3.79641738869551e-26 miRNAWalker2_validate -0.561492324380912 7.81697970755561e-16 NA NA NA hsa-miR-200a-5p PTGS1 -0.612785350735232 0.00678577753061689 2.09881864648574 3.79641738869551e-26 mirMAP -0.133482813201679 0.000635700950254008 NA NA NA hsa-miR-200b-5p PTGS1 -0.369269569070792 0.0737621489480168 2.09881864648574 3.79641738869551e-26 mirMAP -0.21902491663496 3.4984319000812e-07 NA NA NA hsa-miR-20a-3p PTGS1 -1.93545996942606 5.86749215003329e-31 2.09881864648574 3.79641738869551e-26 mirMAP -0.498212280814791 2.467627103988e-25 NA NA NA hsa-miR-320a PTGS1 -0.995486653328464 1.19389676663012e-20 2.09881864648574 3.79641738869551e-26 miRNAWalker2_validate -0.292813802268583 0.000263662713153506 NA NA NA hsa-miR-335-5p PTGS1 -0.960193718665197 5.23061119483484e-12 2.09881864648574 3.79641738869551e-26 mirMAP -0.373947673629766 1.49874187285343e-09 NA NA NA hsa-miR-361-5p PTGS1 -0.652200980992921 2.23302456529972e-21 2.09881864648574 3.79641738869551e-26 miRNAWalker2_validate -0.559863239398036 8.13793917178257e-06 NA NA NA hsa-miR-362-5p PTGS1 -1.31930944822897 5.90925525397408e-17 2.09881864648574 3.79641738869551e-26 mirMAP -0.120539882065213 0.0278251398762836 NA NA NA hsa-miR-423-5p PTGS1 -1.76013839591803 2.19994178835073e-44 2.09881864648574 3.79641738869551e-26 miRNAWalker2_validate -0.616190360145009 5.0849883069979e-23 NA NA NA hsa-miR-429 PTGS1 -0.682420529994949 0.00462213397220848 2.09881864648574 3.79641738869551e-26 miRanda;miRNATAP -0.156784606350982 1.85411031352812e-05 NA NA NA hsa-miR-484 PTGS1 -0.968911692345789 2.45789986401529e-17 2.09881864648574 3.79641738869551e-26 miRNAWalker2_validate -0.637441386534748 3.40774462405296e-18 NA NA NA hsa-miR-491-5p PTGS1 -0.996821208926168 6.43686029153545e-11 2.09881864648574 3.79641738869551e-26 miRanda -0.393962086186172 3.06248166169885e-12 NA NA NA hsa-miR-590-3p PTGS1 -0.58484153433625 1.6489232844135e-06 2.09881864648574 3.79641738869551e-26 PITA;miRanda;mirMAP;miRNATAP -0.385067616274035 8.30077572500957e-08 NA NA NA hsa-miR-590-5p PTGS1 -0.778106902153173 1.13576371947651e-09 2.09881864648574 3.79641738869551e-26 miRanda -0.393723944231998 6.49143077672753e-09 NA NA NA hsa-miR-708-5p PTGS1 -1.92595740173581 2.59035129879776e-32 2.09881864648574 3.79641738869551e-26 miRNAWalker2_validate -0.363013565177174 6.01523858812253e-13 NA NA NA hsa-miR-744-5p PTGS1 -0.565890591451025 7.28129976137206e-06 2.09881864648574 3.79641738869551e-26 miRNAWalker2_validate -0.414307748258397 2.12036752806466e-09 NA NA NA hsa-miR-766-3p PTGS1 -0.49987265344101 0.000133621347277879 2.09881864648574 3.79641738869551e-26 miRNAWalker2_validate -0.397421487480903 2.8866081904716e-09 NA NA NA hsa-miR-92a-3p PTGS1 -1.46190744133 3.47140194919109e-41 2.09881864648574 3.79641738869551e-26 miRNAWalker2_validate -0.910390572602923 5.0480986839116e-38 NA NA NA hsa-miR-375 PTH2R -3.07641574130359 1.01411669962478e-67 0.697312726841854 0.00989063050532796 miRanda -0.201078677233529 0.000437850813365148 NA NA NA hsa-miR-324-3p PTP4A3 0.339294430945761 0.00312401775604061 -1.58000350586859 9.55730584863223e-22 MirTarget -0.195321483243228 0.0021940236738819 NA NA NA hsa-miR-375 PTPN14 -3.07641574130359 1.01411669962478e-67 0.937346529809479 2.09612748483008e-13 mirMAP -0.23866015305474 4.53911849045328e-19 NA NA NA hsa-miR-375 PTPN21 -3.07641574130359 1.01411669962478e-67 0.558407787066414 1.92735409304202e-11 miRanda -0.124481936192727 1.40867634815908e-12 NA NA NA hsa-miR-375 PTPRE -3.07641574130359 1.01411669962478e-67 0.444144633216795 0.000254836953263916 miRanda -0.189828834852034 5.40597305511469e-14 NA NA NA hsa-miR-375 QKI -3.07641574130359 1.01411669962478e-67 0.543765718252347 4.36339440435016e-06 miRanda -0.166563374499497 1.92502232272394e-11 NA NA NA hsa-miR-375 RAB38 -3.07641574130359 1.01411669962478e-67 1.54532999622679 2.91806643653696e-20 miRanda -0.496557395267308 9.73743408534721e-50 NA NA NA hsa-miR-375 RAC2 -3.07641574130359 1.01411669962478e-67 0.209108471175413 0.137967733316311 miRanda -0.16469448751899 2.3430886915622e-08 NA NA NA hsa-miR-375 RASSF8 -3.07641574130359 1.01411669962478e-67 0.472544173399728 0.00010761874873571 miRNAWalker2_validate;miRNATAP -0.109215120037169 2.35084910209253e-05 NA NA NA hsa-miR-375 RBBP8 -3.07641574130359 1.01411669962478e-67 0.760139431314125 2.32282005657594e-22 miRNAWalker2_validate -0.179374215885317 5.40174678804952e-28 NA NA NA hsa-miR-375 RBM24 -3.07641574130359 1.01411669962478e-67 0.635404374922298 0.00306964673208088 PITA;miRanda;miRNATAP -0.224646469381033 6.63998718885675e-07 NA NA NA hsa-miR-375 RBPMS -3.07641574130359 1.01411669962478e-67 1.17408876400396 7.10697576869284e-17 miRanda -0.390197032082236 2.53018582819728e-43 NA NA NA hsa-miR-130a-3p REPS2 0.00961131533334214 0.934528436622002 -1.01789618058804 1.49703988879984e-12 MirTarget -0.220827698797498 3.78700007743774e-05 NA NA NA hsa-miR-142-5p REPS2 -0.570537423718147 5.59576699766966e-05 -1.01789618058804 1.49703988879984e-12 PITA;mirMAP -0.103526531352349 0.0189073106298038 NA NA NA hsa-miR-181a-2-3p REPS2 -0.172331119791391 0.0620577531562451 -1.01789618058804 1.49703988879984e-12 MirTarget -0.233186717860755 0.000629238845157226 NA NA NA hsa-miR-181a-5p REPS2 -0.345696423622306 0.000458417065949032 -1.01789618058804 1.49703988879984e-12 MirTarget -0.170075528205439 0.00753836709790651 NA NA NA hsa-miR-181b-5p REPS2 -0.0216723299660488 0.812298103317658 -1.01789618058804 1.49703988879984e-12 MirTarget -0.176024850881521 0.0111057404814097 NA NA NA hsa-miR-181c-5p REPS2 0.216106163143198 0.0372442927577835 -1.01789618058804 1.49703988879984e-12 MirTarget -0.296506443388012 8.51735594788398e-07 NA NA NA hsa-miR-199a-3p REPS2 0.0553473600849195 0.587002550685305 -1.01789618058804 1.49703988879984e-12 PITA;miRNATAP -0.17112849141658 0.00571623751723763 NA NA NA hsa-miR-199b-3p REPS2 0.0592501088066051 0.561598445904767 -1.01789618058804 1.49703988879984e-12 PITA;miRNATAP -0.170573361085247 0.00578721808585889 NA NA NA hsa-miR-23a-3p REPS2 0.403368902936407 3.67910482846993e-06 -1.01789618058804 1.49703988879984e-12 MirTarget -0.307950306142417 1.68124639207499e-05 NA NA NA hsa-miR-23b-3p REPS2 0.601466385152159 1.2679337399541e-12 -1.01789618058804 1.49703988879984e-12 MirTarget -0.359472345591343 7.01519418456528e-07 NA NA NA hsa-miR-26a-5p REPS2 0.255072671612547 2.10804942505379e-05 -1.01789618058804 1.49703988879984e-12 miRNATAP -0.485438860476063 4.04581330450365e-06 NA NA NA hsa-miR-330-3p REPS2 0.648758240701829 1.73283773523948e-07 -1.01789618058804 1.49703988879984e-12 mirMAP -0.161478361732015 0.00138907727855707 NA NA NA hsa-miR-338-3p REPS2 -0.289775600192434 0.0820821857540406 -1.01789618058804 1.49703988879984e-12 miRanda -0.101351061024185 0.00706460692959187 NA NA NA hsa-miR-34c-3p REPS2 0.518747397740078 0.00158532638288121 -1.01789618058804 1.49703988879984e-12 mirMAP -0.184401007886306 1.39085745569037e-06 NA NA NA hsa-miR-452-3p REPS2 0.160736173909803 0.228583481808647 -1.01789618058804 1.49703988879984e-12 MirTarget -0.158439403373615 0.000847574662798077 NA NA NA hsa-miR-375 REV3L -3.07641574130359 1.01411669962478e-67 0.806533619800639 8.50251733237482e-09 miRanda -0.261374413136702 2.372068154249e-19 NA NA NA hsa-miR-375 RGN -3.07641574130359 1.01411669962478e-67 1.48338513648236 3.69206254356438e-16 miRanda -0.442667081970783 2.09850003818467e-32 NA NA NA hsa-miR-375 RGS16 -3.07641574130359 1.01411669962478e-67 0.696666548513421 0.00124350672971321 miRNATAP -0.355335073561924 1.81143344831547e-15 NA NA NA hsa-miR-375 RHOQ -3.07641574130359 1.01411669962478e-67 0.58368329323963 9.07804417820187e-22 miRNAWalker2_validate;miRanda -0.138848840027928 9.01611488770629e-28 NA NA NA hsa-miR-375 RIMKLB -3.07641574130359 1.01411669962478e-67 0.501624344183577 9.51344793708893e-11 miRanda -0.161142071781319 5.76081062787907e-24 NA NA NA hsa-miR-375 RIMS3 -3.07641574130359 1.01411669962478e-67 1.24594188411049 5.62216527625685e-22 miRNAWalker2_validate -0.354966023466949 2.41174166203417e-41 NA NA NA hsa-miR-375 RNASEL -3.07641574130359 1.01411669962478e-67 0.668670830704551 1.12951525653862e-19 miRanda -0.178883999467423 6.02265757787349e-32 NA NA NA hsa-miR-128-3p RND3 -0.314011160241606 0.000267378314657252 1.43346447288366 1.16970800678136e-17 MirTarget -0.385949323087122 6.29572235722568e-06 NA NA NA hsa-miR-148a-5p RND3 -1.02522933532111 6.47121686767e-19 1.43346447288366 1.16970800678136e-17 miRNATAP -0.608343315529521 1.07511988910942e-24 NA NA NA hsa-miR-148b-5p RND3 -1.04534361724991 2.31801722055734e-12 1.43346447288366 1.16970800678136e-17 MirTarget -0.346150833078308 3.6936820780738e-12 NA NA NA hsa-miR-16-2-3p RND3 -0.615426607127207 4.13943192730969e-05 1.43346447288366 1.16970800678136e-17 MirTarget -0.119266695420133 0.0171592046770763 NA NA NA hsa-miR-17-5p RND3 -1.75236465070226 3.95158641627966e-36 1.43346447288366 1.16970800678136e-17 miRNAWalker2_validate;miRTarBase;TargetScan -0.498283004407003 3.83979531744473e-26 22132820 Up regulated miR 17 promotes cell proliferation tumour growth and cell cycle progression by targeting the RND3 tumour suppressor gene in colorectal carcinoma; We also confirmed that miR-17 exerted this function by directly targeting RND3 in vitro and that the expression of miR-17 was negatively correlated with that of RND3 in CRC tissues and CRC cells; Moreover miR-17 inhibition led to tumour growth suppression and up-regulation of RND3 expression in a nude mouse xenograft model; In conclusion the present study suggests that miR-17 plays an important role in CRC carcinogenesis by targeting RND3 and may be a therapeutic agent for CRC progression;tumorigenesis colorectal cancer hsa-miR-186-5p RND3 -0.567811924899222 1.37607142180843e-13 1.43346447288366 1.16970800678136e-17 mirMAP -0.61136890318199 6.00904016824357e-11 NA NA NA hsa-miR-1976 RND3 -0.835612747570637 1.8316209115412e-14 1.43346447288366 1.16970800678136e-17 MirTarget;miRNATAP -0.405715234288213 5.18071463409586e-10 NA NA NA hsa-miR-200c-3p RND3 -2.03814857577671 1.11482598742444e-54 1.43346447288366 1.16970800678136e-17 MirTarget;miRNATAP -0.667002712666272 1.36942067321917e-46 23821457 MicroRNA 200c regulates the sensitivity of chemotherapy of gastric cancer SGC7901/DDP cells by directly targeting RhoE gastric cancer hsa-miR-26b-5p RND3 -0.737437044119268 6.43607077094955e-18 1.43346447288366 1.16970800678136e-17 miRNATAP -0.363235953926691 1.46103929443908e-05 NA NA NA hsa-miR-29b-3p RND3 -0.305845215326375 0.00477759838414869 1.43346447288366 1.16970800678136e-17 MirTarget;miRNATAP -0.218313724233086 0.00135058916909466 NA NA NA hsa-miR-3065-5p RND3 -1.04645334963496 3.19942342920484e-08 1.43346447288366 1.16970800678136e-17 mirMAP -0.1602784897509 3.7053822286696e-05 NA NA NA hsa-miR-30d-5p RND3 -0.804765144490435 1.42480384315577e-16 1.43346447288366 1.16970800678136e-17 miRNATAP -0.669194267906955 6.37707017750566e-21 NA NA NA hsa-miR-324-5p RND3 -0.539970285576229 1.69955273262756e-05 1.43346447288366 1.16970800678136e-17 miRanda -0.195120674606888 0.000833972604892239 NA NA NA hsa-miR-335-3p RND3 -0.625191833097363 1.64208673352814e-06 1.43346447288366 1.16970800678136e-17 mirMAP -0.351611637047816 2.08275880900856e-10 NA NA NA hsa-miR-3607-3p RND3 -1.16606393006353 2.28951370382029e-07 1.43346447288366 1.16970800678136e-17 MirTarget;miRNATAP -0.19544302757479 9.02592246784408e-10 NA NA NA hsa-miR-361-5p RND3 -0.652200980992921 2.23302456529972e-21 1.43346447288366 1.16970800678136e-17 miRanda -0.389097196766072 0.000194282475453449 NA NA NA hsa-miR-582-3p RND3 -0.693858322916391 6.21181920447973e-07 1.43346447288366 1.16970800678136e-17 PITA -0.154941520594371 0.00317741412079112 NA NA NA hsa-miR-590-3p RND3 -0.58484153433625 1.6489232844135e-06 1.43346447288366 1.16970800678136e-17 miRanda;mirMAP -0.31172201345586 1.73204944796285e-07 NA NA NA hsa-miR-590-5p RND3 -0.778106902153173 1.13576371947651e-09 1.43346447288366 1.16970800678136e-17 miRanda -0.338891370336686 1.66954325568077e-09 NA NA NA hsa-miR-93-5p RND3 -2.02673564951393 4.11722430511061e-49 1.43346447288366 1.16970800678136e-17 miRNAWalker2_validate -0.512960444727881 2.01295513235511e-28 NA NA NA hsa-miR-942-5p RND3 -0.379108527613044 0.00732116056229795 1.43346447288366 1.16970800678136e-17 MirTarget -0.157106668667622 0.00285029104224038 NA NA NA hsa-miR-96-5p RND3 -2.57339472553563 5.77311209747623e-53 1.43346447288366 1.16970800678136e-17 TargetScan -0.478814599453186 1.7443385129927e-38 NA NA NA hsa-miR-375 ROBO2 -3.07641574130359 1.01411669962478e-67 1.16074439627211 9.99156118638931e-09 PITA;miRanda -0.366692678538334 3.19267527652646e-18 NA NA NA hsa-miR-375 RPRM -3.07641574130359 1.01411669962478e-67 1.22786530793141 8.54858045408823e-10 miRanda -0.437112867492224 1.65262366523245e-26 NA NA NA hsa-miR-375 RRN3P2 -3.07641574130359 1.01411669962478e-67 0.643372240583841 2.15159601436939e-05 miRanda -0.21184880350091 2.41219905774907e-11 NA NA NA hsa-miR-375 RSU1 -3.07641574130359 1.01411669962478e-67 0.537398133787143 2.5424208825607e-15 miRanda -0.158460065109077 6.45198109042435e-30 NA NA NA hsa-miR-375 RUNX2 -3.07641574130359 1.01411669962478e-67 0.68707378933515 4.99044041186843e-08 miRNATAP -0.208366929057217 2.41929863009825e-15 NA NA NA hsa-miR-375 RYR2 -3.07641574130359 1.01411669962478e-67 0.822464227596756 0.00211422756372423 miRanda -0.246605028904804 1.27652374222733e-05 NA NA NA hsa-let-7b-3p S1PR3 -0.506893427781244 8.27914591468333e-08 0.904448975977221 1.51869313280507e-09 mirMAP -0.444539435847544 3.41316581533721e-11 NA NA NA hsa-miR-126-5p S1PR3 -0.222731872217005 0.0500978215521652 0.904448975977221 1.51869313280507e-09 MirTarget -0.114475512466615 0.045724976773438 NA NA NA hsa-miR-130b-3p S1PR3 -1.0141083264891 9.96856467852323e-16 0.904448975977221 1.51869313280507e-09 mirMAP -0.146932772061713 0.00329274981831699 NA NA NA hsa-miR-146b-5p S1PR3 -1.70281490248323 9.08060943822522e-35 0.904448975977221 1.51869313280507e-09 miRanda -0.107798767251235 0.0141023386010736 NA NA NA hsa-miR-30a-5p S1PR3 -0.508562243919922 3.02321261664392e-06 0.904448975977221 1.51869313280507e-09 mirMAP -0.236824136026374 6.01035436835633e-05 NA NA NA hsa-miR-30b-5p S1PR3 -1.16764575603669 1.75395013539893e-20 0.904448975977221 1.51869313280507e-09 mirMAP -0.292534859612056 2.53252773214865e-09 NA NA NA hsa-miR-30c-5p S1PR3 -0.746747513281496 1.32431877874928e-12 0.904448975977221 1.51869313280507e-09 mirMAP -0.35220200111523 3.83324801501493e-09 NA NA NA hsa-miR-30d-5p S1PR3 -0.804765144490435 1.42480384315577e-16 0.904448975977221 1.51869313280507e-09 mirMAP -0.43421605148734 1.04427022157395e-11 NA NA NA hsa-miR-30e-5p S1PR3 0.0410434441382375 0.610918464525074 0.904448975977221 1.51869313280507e-09 mirMAP -0.27922649901743 0.00057699863765314 NA NA NA hsa-miR-335-3p S1PR3 -0.625191833097363 1.64208673352814e-06 0.904448975977221 1.51869313280507e-09 mirMAP -0.262207978281908 8.07961516810448e-08 NA NA NA hsa-miR-33a-3p S1PR3 -0.612459021907227 0.000347410219059134 0.904448975977221 1.51869313280507e-09 mirMAP -0.22707567568222 2.45952963625067e-09 NA NA NA hsa-miR-342-3p S1PR3 -1.25856075011434 9.5039654565453e-34 0.904448975977221 1.51869313280507e-09 miRanda -0.254089348426195 1.37722292562581e-05 NA NA NA hsa-miR-34c-5p S1PR3 -0.411316782408141 0.0146968432653683 0.904448975977221 1.51869313280507e-09 MirTarget;miRanda -0.119582921221217 0.00190615513722011 NA NA NA hsa-miR-429 S1PR3 -0.682420529994949 0.00462213397220848 0.904448975977221 1.51869313280507e-09 miRanda;miRNATAP -0.12759433116796 1.67387061633203e-06 NA NA NA hsa-miR-454-3p S1PR3 -1.05348676011504 1.08188735671628e-16 0.904448975977221 1.51869313280507e-09 mirMAP -0.291945984011467 2.7023582484614e-09 NA NA NA hsa-miR-576-5p S1PR3 -0.962105441345164 5.68435745070752e-14 0.904448975977221 1.51869313280507e-09 MirTarget -0.279057355595993 1.20729569089538e-08 NA NA NA hsa-miR-590-3p S1PR3 -0.58484153433625 1.6489232844135e-06 0.904448975977221 1.51869313280507e-09 mirMAP -0.19919946223586 0.000157949985317333 NA NA NA hsa-miR-590-5p S1PR3 -0.778106902153173 1.13576371947651e-09 0.904448975977221 1.51869313280507e-09 miRanda -0.191487666580065 0.000124105266011114 NA NA NA hsa-miR-766-3p S1PR3 -0.49987265344101 0.000133621347277879 0.904448975977221 1.51869313280507e-09 MirTarget -0.177734140710117 0.000311773952546172 NA NA NA hsa-miR-9-5p S1PR3 -1.13944963456975 4.52386797543032e-07 0.904448975977221 1.51869313280507e-09 mirMAP -0.108845434445943 0.000118865788139362 NA NA NA hsa-miR-375 SAMD11 -3.07641574130359 1.01411669962478e-67 0.828178346027663 1.13911501776536e-05 miRNAWalker2_validate;miRanda -0.241375148342068 1.19503975819342e-09 NA NA NA hsa-miR-375 SAMD4A -3.07641574130359 1.01411669962478e-67 0.75012530256985 5.4754199595004e-09 miRNAWalker2_validate;miRanda -0.264333154587082 1.73543934308453e-23 NA NA NA hsa-miR-375 SCN2B -3.07641574130359 1.01411669962478e-67 1.99132482333399 2.36443681985245e-19 miRNATAP -0.597975485082886 2.76274855764416e-40 NA NA NA hsa-miR-375 SDC1 -3.07641574130359 1.01411669962478e-67 0.96302983292325 5.65051464682676e-09 miRNAWalker2_validate -0.213761524263688 1.00179382905175e-09 NA NA NA hsa-miR-375 SDC2 -3.07641574130359 1.01411669962478e-67 0.618952725642743 1.18106553956612e-06 miRanda -0.200510342940803 4.74144940834534e-14 NA NA NA hsa-miR-375 SEC23A -3.07641574130359 1.01411669962478e-67 1.06283375992529 2.3869579680039e-27 miRNAWalker2_validate;miRanda -0.313463141716349 8.66923461535596e-58 21593139 A computational analysis predicted the 3'-UTR of the SEC23A gene as a potential target for both miR-375 and miR-200c; Here we show that the 3'-UTR of SEC23A mRNA is indeed a target for miR-375 and miR-200c and that both miRNAs downregulate Sec23A protein expression when ectopically expressed in human 293T cells; In primary samples of CaP we found a direct correlation between reduction of SEC23A mRNA and overexpression of miR-375 but not of miR-200c; The reduced levels of Sec23A protein were inversely correlated to the increased amount of miR-375 in the LNCaP and DU145 CaP cell lines when compared with normal prostate fibroblasts prostate cancer hsa-miR-375 SEMA3C -3.07641574130359 1.01411669962478e-67 0.658643469905364 4.11996169459947e-05 miRNAWalker2_validate -0.145969543542324 1.79325204427799e-05 NA NA NA hsa-miR-375 SETBP1 -3.07641574130359 1.01411669962478e-67 0.766092982406094 5.33978799628905e-11 miRanda;miRNATAP -0.250348393288196 2.01859802546335e-25 NA NA NA hsa-miR-375 SH3BGRL -3.07641574130359 1.01411669962478e-67 0.912146034621237 3.19988156910473e-13 miRanda -0.290228324390399 1.17499090216231e-29 NA NA NA hsa-miR-375 SH3GLB1 -3.07641574130359 1.01411669962478e-67 0.549532751247008 2.77602269695714e-29 miRanda -0.119846073344679 1.94860612536229e-31 NA NA NA hsa-miR-375 SHB -3.07641574130359 1.01411669962478e-67 0.380344198272311 0.000664133374157224 miRNATAP -0.158672442046018 9.86879438102333e-12 NA NA NA hsa-miR-375 SHISA9 -3.07641574130359 1.01411669962478e-67 1.77604689589367 5.60826819979049e-06 miRanda -0.317835382140964 0.000133423759049874 NA NA NA hsa-miR-125a-3p SIM2 0.335450161542356 0.00400908432417963 -3.03141072243389 2.90300379555578e-60 miRanda -0.3403859398548 9.68635057578997e-06 NA NA NA hsa-miR-129-5p SIM2 0.664119897121715 0.0020737112165816 -3.03141072243389 2.90300379555578e-60 miRanda -0.159171312556864 0.000173675177994312 NA NA NA hsa-miR-133b SIM2 1.6405074687617 4.27792135252442e-19 -3.03141072243389 2.90300379555578e-60 miRanda -0.345282149152846 4.33990190172105e-14 NA NA NA hsa-miR-450b-5p SIM2 0.857642158166269 2.78318878314148e-06 -3.03141072243389 2.90300379555578e-60 miRNATAP -0.14750118435773 0.00214557677205012 NA NA NA hsa-miR-452-5p SIM2 0.586743954667332 4.21190671320052e-08 -3.03141072243389 2.90300379555578e-60 mirMAP -0.598792189895712 1.00196491662248e-13 NA NA NA hsa-miR-493-3p SIM2 0.675983419893735 9.22087540085149e-06 -3.03141072243389 2.90300379555578e-60 miRNATAP -0.197070363048317 0.000679099749957874 NA NA NA hsa-miR-375 SLC16A2 -3.07641574130359 1.01411669962478e-67 0.899096071720209 1.22155210234776e-13 PITA;miRanda;miRNATAP -0.259615205941171 4.65136415314297e-25 23685355 Expression of the potential downstream targets of miR-375 YAP1 a growth inhibitor and SLC16a2 a transporter of thyroid hormone was down-regulated in the tumors suggesting that miR-375 is a negative regulator of the expression of these genes thyroid cancer hsa-let-7a-3p SLC18A2 -0.885792199222571 4.41035630133324e-17 2.39359596502831 2.40481990766754e-12 MirTarget;miRNATAP -1.08263980354787 6.34788539300592e-16 NA NA NA hsa-let-7b-3p SLC18A2 -0.506893427781244 8.27914591468333e-08 2.39359596502831 2.40481990766754e-12 MirTarget;miRNATAP -0.820433236441338 1.22729376841594e-07 NA NA NA hsa-let-7f-1-3p SLC18A2 -0.159920578752557 0.190200799823397 2.39359596502831 2.40481990766754e-12 MirTarget -0.361289927323727 0.00341087273500694 NA NA NA hsa-miR-141-3p SLC18A2 -1.79566520772936 2.43414267305203e-29 2.39359596502831 2.40481990766754e-12 TargetScan -0.814051047606124 9.08819345437974e-22 NA NA NA hsa-miR-148a-5p SLC18A2 -1.02522933532111 6.47121686767e-19 2.39359596502831 2.40481990766754e-12 miRNATAP -0.559146589543293 6.83602780619237e-06 NA NA NA hsa-miR-148b-5p SLC18A2 -1.04534361724991 2.31801722055734e-12 2.39359596502831 2.40481990766754e-12 MirTarget -0.742701708897789 1.23324658061916e-13 NA NA NA hsa-miR-26b-3p SLC18A2 -0.470600927165998 0.000240397864249736 2.39359596502831 2.40481990766754e-12 MirTarget -0.525341224415184 5.04290633185443e-06 NA NA NA hsa-miR-335-3p SLC18A2 -0.625191833097363 1.64208673352814e-06 2.39359596502831 2.40481990766754e-12 mirMAP -0.346364428938025 0.00221464434666492 NA NA NA hsa-miR-33a-3p SLC18A2 -0.612459021907227 0.000347410219059134 2.39359596502831 2.40481990766754e-12 mirMAP -0.366661331263423 3.18269661347933e-05 NA NA NA hsa-miR-495-3p SLC18A2 -0.627906813412206 1.45002911833623e-07 2.39359596502831 2.40481990766754e-12 mirMAP -0.59176847423924 1.45837374425336e-06 NA NA NA hsa-miR-589-5p SLC18A2 -0.816440979173972 2.93437435111593e-17 2.39359596502831 2.40481990766754e-12 MirTarget -0.769821971847053 2.33337033576924e-07 NA NA NA hsa-miR-590-3p SLC18A2 -0.58484153433625 1.6489232844135e-06 2.39359596502831 2.40481990766754e-12 mirMAP -0.546835371478685 5.87769778843937e-06 NA NA NA hsa-miR-664a-3p SLC18A2 -0.771665734879283 3.09460128204882e-14 2.39359596502831 2.40481990766754e-12 mirMAP -0.765507197741319 7.31810853044739e-08 NA NA NA hsa-miR-7-1-3p SLC18A2 -1.45703750327525 1.75378847810364e-30 2.39359596502831 2.40481990766754e-12 mirMAP -1.03278821280713 3.48574230642763e-22 NA NA NA hsa-miR-375 SLC22A4 -3.07641574130359 1.01411669962478e-67 0.484557266445802 0.00474900590244071 miRanda -0.141111318194472 0.000100039560544934 NA NA NA hsa-miR-375 SLC25A24 -3.07641574130359 1.01411669962478e-67 0.634539945262397 6.21639885308108e-10 miRanda -0.167117220581398 8.11926585888709e-15 NA NA NA hsa-miR-375 SLC46A2 -3.07641574130359 1.01411669962478e-67 1.83577956316539 3.33893348096282e-15 miRanda -0.554019928493669 5.48463481891535e-31 NA NA NA hsa-miR-375 SLC6A6 -3.07641574130359 1.01411669962478e-67 0.792398052392211 5.66867353855931e-10 miRNAWalker2_validate -0.308375565794982 8.9980456958112e-33 NA NA NA hsa-miR-106a-5p SLFN5 -1.76751200862602 7.79031604495387e-24 0.884152204869388 7.69759060556718e-09 mirMAP -0.315062296498122 1.67514003535109e-19 NA NA NA hsa-miR-106b-5p SLFN5 -1.03194006819592 5.97693261279532e-24 0.884152204869388 7.69759060556718e-09 mirMAP -0.462801082196596 2.76518393307679e-14 NA NA NA hsa-miR-135a-5p SLFN5 -1.05960103698212 1.08082165806244e-09 0.884152204869388 7.69759060556718e-09 MirTarget -0.266150420841683 4.39539345114512e-13 NA NA NA hsa-miR-141-5p SLFN5 -1.26042882931431 1.07134351805273e-31 0.884152204869388 7.69759060556718e-09 mirMAP -0.260539262353894 6.66085101828197e-06 NA NA NA hsa-miR-16-2-3p SLFN5 -0.615426607127207 4.13943192730969e-05 0.884152204869388 7.69759060556718e-09 mirMAP -0.227820693074975 3.04457291152346e-07 NA NA NA hsa-miR-17-3p SLFN5 -1.00900556864081 4.33187133364694e-23 0.884152204869388 7.69759060556718e-09 mirMAP -0.529407605429918 2.41701380873985e-18 NA NA NA hsa-miR-17-5p SLFN5 -1.75236465070226 3.95158641627966e-36 0.884152204869388 7.69759060556718e-09 mirMAP -0.463377433924407 3.64114059730261e-28 NA NA NA hsa-miR-195-3p SLFN5 -0.598450619600341 1.01415597921415e-08 0.884152204869388 7.69759060556718e-09 mirMAP -0.144564899997899 0.0216420740390204 NA NA NA hsa-miR-200c-3p SLFN5 -2.03814857577671 1.11482598742444e-54 0.884152204869388 7.69759060556718e-09 mirMAP -0.361944554575131 3.60351980379987e-16 NA NA NA hsa-miR-20a-5p SLFN5 -1.8613782696103 3.92351368893149e-34 0.884152204869388 7.69759060556718e-09 mirMAP -0.426288352664932 2.26765050950017e-28 NA NA NA hsa-miR-20b-5p SLFN5 -1.58314196476133 5.61327965534576e-17 0.884152204869388 7.69759060556718e-09 mirMAP -0.230258183464796 4.96309959381848e-12 NA NA NA hsa-miR-2355-5p SLFN5 -0.280181037431566 0.00411194169830979 0.884152204869388 7.69759060556718e-09 MirTarget -0.214384008232085 0.00161145832089177 NA NA NA hsa-miR-26b-3p SLFN5 -0.470600927165998 0.000240397864249736 0.884152204869388 7.69759060556718e-09 mirMAP -0.106833773591721 0.0384549680272657 NA NA NA hsa-miR-26b-5p SLFN5 -0.737437044119268 6.43607077094955e-18 0.884152204869388 7.69759060556718e-09 mirMAP -0.546970359348863 1.44116481420959e-13 NA NA NA hsa-miR-29a-5p SLFN5 -0.458517912323331 0.000412683536074951 0.884152204869388 7.69759060556718e-09 mirMAP -0.299561158929108 2.48050176698874e-09 NA NA NA hsa-miR-29b-2-5p SLFN5 -0.789021480062028 2.59438538341121e-14 0.884152204869388 7.69759060556718e-09 MirTarget -0.333715037407503 7.46444462302449e-08 NA NA NA hsa-miR-30d-3p SLFN5 -0.917692758870647 7.72239658481192e-16 0.884152204869388 7.69759060556718e-09 mirMAP -0.363187944723015 7.79541958736909e-11 NA NA NA hsa-miR-335-3p SLFN5 -0.625191833097363 1.64208673352814e-06 0.884152204869388 7.69759060556718e-09 MirTarget;mirMAP -0.2579639832328 2.43095883954468e-07 NA NA NA hsa-miR-335-5p SLFN5 -0.960193718665197 5.23061119483484e-12 0.884152204869388 7.69759060556718e-09 miRNAWalker2_validate -0.225990261531352 1.07864502557114e-06 NA NA NA hsa-miR-361-5p SLFN5 -0.652200980992921 2.23302456529972e-21 0.884152204869388 7.69759060556718e-09 miRanda;mirMAP -0.637743282755126 4.7971801055521e-12 NA NA NA hsa-miR-374b-5p SLFN5 -0.221226738167835 0.00747242957932152 0.884152204869388 7.69759060556718e-09 mirMAP -0.316252531502649 8.33399356989215e-05 NA NA NA hsa-miR-500a-5p SLFN5 -0.724031963091637 1.07520204401534e-07 0.884152204869388 7.69759060556718e-09 mirMAP -0.262605421367617 3.82805416547696e-08 NA NA NA hsa-miR-532-5p SLFN5 -0.819279743754759 7.8621216315329e-15 0.884152204869388 7.69759060556718e-09 mirMAP -0.277145706951045 5.71791501779227e-06 NA NA NA hsa-miR-576-5p SLFN5 -0.962105441345164 5.68435745070752e-14 0.884152204869388 7.69759060556718e-09 mirMAP -0.327689209432743 4.57451671267224e-11 NA NA NA hsa-miR-589-5p SLFN5 -0.816440979173972 2.93437435111593e-17 0.884152204869388 7.69759060556718e-09 MirTarget -0.563587785003326 3.34449113690567e-18 NA NA NA hsa-miR-590-3p SLFN5 -0.58484153433625 1.6489232844135e-06 0.884152204869388 7.69759060556718e-09 PITA;miRanda;mirMAP -0.260019712445089 1.24101408520616e-06 NA NA NA hsa-miR-590-5p SLFN5 -0.778106902153173 1.13576371947651e-09 0.884152204869388 7.69759060556718e-09 mirMAP -0.311606213140141 6.39455645808227e-10 NA NA NA hsa-miR-625-3p SLFN5 -0.749969332494 2.25550410467727e-14 0.884152204869388 7.69759060556718e-09 mirMAP -0.157247815779711 0.0174763766120056 NA NA NA hsa-miR-629-3p SLFN5 -1.01531686151469 1.96827867612758e-09 0.884152204869388 7.69759060556718e-09 mirMAP -0.113835071352763 0.0043647843789799 NA NA NA hsa-miR-708-3p SLFN5 -1.69343810530707 2.2954130070805e-38 0.884152204869388 7.69759060556718e-09 mirMAP -0.146913791943314 0.0018123613255475 NA NA NA hsa-miR-93-5p SLFN5 -2.02673564951393 4.11722430511061e-49 0.884152204869388 7.69759060556718e-09 mirMAP -0.464123836732849 6.44166656333175e-29 NA NA NA hsa-miR-375 SMAD7 -3.07641574130359 1.01411669962478e-67 0.492178812449965 1.91196691005184e-08 miRanda -0.153926107253634 2.88903203313998e-17 NA NA NA hsa-let-7a-3p SMOC1 -0.885792199222571 4.41035630133324e-17 2.08779095022064 8.55366785409222e-15 miRNATAP -0.931253013694258 1.0397323075574e-18 NA NA NA hsa-let-7b-3p SMOC1 -0.506893427781244 8.27914591468333e-08 2.08779095022064 8.55366785409222e-15 miRNATAP -0.852890709376852 2.35078085825879e-12 NA NA NA hsa-miR-106a-5p SMOC1 -1.76751200862602 7.79031604495387e-24 2.08779095022064 8.55366785409222e-15 miRNATAP -0.424785520960383 1.67350143044242e-11 NA NA NA hsa-miR-106b-5p SMOC1 -1.03194006819592 5.97693261279532e-24 2.08779095022064 8.55366785409222e-15 miRNATAP -1.07290020617859 4.9494265547556e-24 NA NA NA hsa-miR-130b-3p SMOC1 -1.0141083264891 9.96856467852323e-16 2.08779095022064 8.55366785409222e-15 miRNATAP -0.705395502101673 1.7526842218089e-15 NA NA NA hsa-miR-130b-5p SMOC1 -1.15237450600836 1.6187151436434e-14 2.08779095022064 8.55366785409222e-15 miRNATAP -0.581388150388675 7.58515040816117e-15 NA NA NA hsa-miR-146b-5p SMOC1 -1.70281490248323 9.08060943822522e-35 2.08779095022064 8.55366785409222e-15 miRanda -0.43764958263284 2.94397654072769e-08 NA NA NA hsa-miR-17-5p SMOC1 -1.75236465070226 3.95158641627966e-36 2.08779095022064 8.55366785409222e-15 TargetScan;miRNATAP -0.709580945024206 1.1004511413145e-20 NA NA NA hsa-miR-19a-3p SMOC1 -1.31708679186777 4.80964007387792e-14 2.08779095022064 8.55366785409222e-15 miRNATAP -0.435700554566557 1.61555989517144e-11 NA NA NA hsa-miR-19b-3p SMOC1 -1.59390221063917 1.21812878827867e-26 2.08779095022064 8.55366785409222e-15 miRNATAP -0.553286565853585 5.31639739411513e-14 NA NA NA hsa-miR-20a-5p SMOC1 -1.8613782696103 3.92351368893149e-34 2.08779095022064 8.55366785409222e-15 miRNATAP -0.625650125164606 3.86100869459201e-19 NA NA NA hsa-miR-20b-5p SMOC1 -1.58314196476133 5.61327965534576e-17 2.08779095022064 8.55366785409222e-15 miRNATAP -0.407002291221738 7.00091340548304e-12 NA NA NA hsa-miR-301a-3p SMOC1 -0.501721475120081 0.000262747397142621 2.08779095022064 8.55366785409222e-15 miRNATAP -0.212693235860955 0.0129438396664234 NA NA NA hsa-miR-454-3p SMOC1 -1.05348676011504 1.08188735671628e-16 2.08779095022064 8.55366785409222e-15 miRNATAP -0.523162831461883 4.58149800371459e-09 NA NA NA hsa-miR-93-5p SMOC1 -2.02673564951393 4.11722430511061e-49 2.08779095022064 8.55366785409222e-15 miRNATAP -0.814084221249299 4.81424635697321e-28 NA NA NA hsa-miR-375 SMYD1 -3.07641574130359 1.01411669962478e-67 1.0428840210428 0.0123798506943091 miRanda -0.281453449823055 0.00143437670524645 NA NA NA hsa-miR-375 SNAI2 -3.07641574130359 1.01411669962478e-67 1.77989957960583 2.473023092599e-21 miRanda -0.444275857746589 6.71404722311088e-30 NA NA NA hsa-miR-375 SNPH -3.07641574130359 1.01411669962478e-67 1.12703538157594 7.81443302779e-14 miRNAWalker2_validate -0.305338210056829 2.5458728517074e-22 NA NA NA hsa-miR-375 SOCS5 -3.07641574130359 1.01411669962478e-67 0.38525912782891 5.67339390986118e-10 miRanda -0.112354321702132 3.37230984728262e-18 NA NA NA hsa-miR-375 SOHLH2 -3.07641574130359 1.01411669962478e-67 1.73362521438822 1.47563338441592e-05 miRanda -0.32688658867262 0.000121129904616181 NA NA NA hsa-miR-375 SORCS1 -3.07641574130359 1.01411669962478e-67 1.10491972575775 1.1162356384977e-06 miRanda -0.474518948197287 1.4918449549112e-24 NA NA NA hsa-miR-375 SOX6 -3.07641574130359 1.01411669962478e-67 0.806492115210638 8.75009540341773e-08 miRNATAP -0.277450480978144 6.5460705979625e-19 NA NA NA hsa-miR-375 SPESP1 -3.07641574130359 1.01411669962478e-67 0.639386340712131 0.0416823109327266 miRanda -0.178723860749138 0.0071966434216019 NA NA NA hsa-let-7a-3p SPOCK3 -0.885792199222571 4.41035630133324e-17 1.69075483078249 5.30721947632864e-15 miRNATAP -0.982287359433758 8.9717073380415e-33 NA NA NA hsa-let-7b-3p SPOCK3 -0.506893427781244 8.27914591468333e-08 1.69075483078249 5.30721947632864e-15 miRNATAP -0.831522360735003 7.95805084995673e-18 NA NA NA hsa-miR-142-3p SPOCK3 -0.668342567225765 0.000202408167795488 1.69075483078249 5.30721947632864e-15 miRanda -0.114630011696996 0.0288690719532813 NA NA NA hsa-miR-148a-5p SPOCK3 -1.02522933532111 6.47121686767e-19 1.69075483078249 5.30721947632864e-15 miRNATAP -0.559121928287498 7.55744535538611e-13 NA NA NA hsa-miR-194-5p SPOCK3 -0.560678555035275 8.78835428037523e-09 1.69075483078249 5.30721947632864e-15 miRNATAP -0.669821745006517 1.41221428674156e-12 NA NA NA hsa-miR-217 SPOCK3 -0.647926571365963 0.000615546232893747 1.69075483078249 5.30721947632864e-15 miRanda -0.296981590675702 1.61993883450938e-09 NA NA NA hsa-miR-338-3p SPOCK3 -0.289775600192434 0.0820821857540406 1.69075483078249 5.30721947632864e-15 miRanda -0.137285725762514 0.0158048733717127 NA NA NA hsa-miR-342-3p SPOCK3 -1.25856075011434 9.5039654565453e-34 1.69075483078249 5.30721947632864e-15 miRanda -0.426375401568531 5.5328925400134e-07 NA NA NA hsa-miR-375 SPOCK3 -3.07641574130359 1.01411669962478e-67 1.69075483078249 5.30721947632864e-15 miRanda -0.452217958578159 1.02857450133604e-23 NA NA NA hsa-miR-491-5p SPOCK3 -0.996821208926168 6.43686029153545e-11 1.69075483078249 5.30721947632864e-15 miRanda -0.342007174199982 1.69848883341822e-08 NA NA NA hsa-miR-590-3p SPOCK3 -0.58484153433625 1.6489232844135e-06 1.69075483078249 5.30721947632864e-15 miRanda;mirMAP;miRNATAP -0.457707036789006 1.96590121859868e-09 NA NA NA hsa-miR-590-5p SPOCK3 -0.778106902153173 1.13576371947651e-09 1.69075483078249 5.30721947632864e-15 miRanda -0.523766569146233 2.62901099721631e-13 NA NA NA hsa-miR-7-1-3p SPOCK3 -1.45703750327525 1.75378847810364e-30 1.69075483078249 5.30721947632864e-15 mirMAP -0.689221606857298 1.94757048072756e-24 NA NA NA hsa-miR-375 SPRED1 -3.07641574130359 1.01411669962478e-67 0.813789987545888 1.20286031070565e-13 miRNAWalker2_validate -0.26006490650898 4.70447531265096e-31 NA NA NA hsa-miR-375 SPRED2 -3.07641574130359 1.01411669962478e-67 0.47530106152189 2.04948751616745e-06 miRanda -0.122871002159045 5.72592836226858e-09 NA NA NA hsa-miR-375 SPRY3 -3.07641574130359 1.01411669962478e-67 0.887395656922229 1.98954333382365e-09 miRNATAP -0.275923628542618 2.7841036573932e-19 NA NA NA hsa-miR-375 SRRM3 -3.07641574130359 1.01411669962478e-67 0.691911646944835 2.31186524070453e-06 miRNATAP -0.16962496435935 4.2064890043999e-08 NA NA NA hsa-miR-375 SSBP2 -3.07641574130359 1.01411669962478e-67 0.639551035773952 6.94595159554059e-17 mirMAP -0.123454377608297 3.68346490804933e-14 NA NA NA hsa-miR-375 ST3GAL2 -3.07641574130359 1.01411669962478e-67 0.451033685181895 1.79518733564178e-07 miRanda -0.197327608465202 1.65854467958448e-29 NA NA NA hsa-miR-375 STMN2 -3.07641574130359 1.01411669962478e-67 0.153894202844525 0.655644812221289 miRanda -0.166700111354496 0.0224690428352841 NA NA NA hsa-miR-375 STX11 -3.07641574130359 1.01411669962478e-67 0.288375689674687 0.0512802456395713 miRanda -0.190236206314607 7.2713705412581e-10 NA NA NA hsa-miR-375 SULF1 -3.07641574130359 1.01411669962478e-67 0.412593457096719 0.0126568620858468 miRanda -0.257933383083297 5.42083357627268e-14 NA NA NA hsa-miR-375 SULT1C4 -3.07641574130359 1.01411669962478e-67 0.691312433789143 0.00639755171069613 miRanda -0.322902297973003 1.15557812426181e-09 NA NA NA hsa-miR-375 SVIL -3.07641574130359 1.01411669962478e-67 1.34209936422738 4.46658392498018e-24 miRNATAP -0.392273698855963 1.14890572132338e-48 NA NA NA hsa-miR-375 SYDE2 -3.07641574130359 1.01411669962478e-67 0.527214765933002 3.16664041230974e-05 miRanda -0.15350655444498 8.53767572762023e-09 NA NA NA hsa-miR-375 SYT15 -3.07641574130359 1.01411669962478e-67 0.741388730160145 7.23327872918491e-08 miRNAWalker2_validate -0.269459701862739 2.28103250345953e-21 NA NA NA hsa-miR-375 SYT9 -3.07641574130359 1.01411669962478e-67 1.7603534182722 4.37659141553635e-12 miRanda -0.415887933560793 8.7663173130571e-15 NA NA NA hsa-miR-375 TACC1 -3.07641574130359 1.01411669962478e-67 1.0956227632267 1.39495798995278e-20 miRanda -0.329551458100429 1.83933410624383e-43 NA NA NA hsa-miR-375 TAF3 -3.07641574130359 1.01411669962478e-67 0.625974964263553 1.79952594600833e-17 miRNAWalker2_validate -0.174575104526743 1.09511609895262e-30 NA NA NA hsa-miR-375 TBX19 -3.07641574130359 1.01411669962478e-67 0.340808290905032 0.000598231309584634 miRNAWalker2_validate -0.127347526992546 9.01941719293543e-10 NA NA NA hsa-miR-375 TF -3.07641574130359 1.01411669962478e-67 0.679401474438248 0.0140041994596531 miRanda -0.27018818045492 3.49015939951698e-06 NA NA NA hsa-miR-375 TFRC -3.07641574130359 1.01411669962478e-67 0.409156967552538 0.000197680361952964 miRanda -0.153734242307514 2.1802609749642e-11 NA NA NA hsa-miR-375 TGFB2 -3.07641574130359 1.01411669962478e-67 0.72561523617964 1.14325632798571e-06 miRNAWalker2_validate -0.260580157445981 3.78912341341187e-17 NA NA NA hsa-let-7a-5p TGFBR3 -0.810823676990507 1.01381033479519e-26 1.47847669496634 9.50277769469809e-26 MirTarget;TargetScan -0.847590325075675 6.13164051584299e-29 NA NA NA hsa-let-7b-5p TGFBR3 -0.221439854958536 0.00904814983284487 1.47847669496634 9.50277769469809e-26 MirTarget -0.278580581988843 0.000190536220426911 NA NA NA hsa-let-7d-5p TGFBR3 -0.767545769968654 1.765411565791e-19 1.47847669496634 9.50277769469809e-26 MirTarget -0.623376999334151 4.58396149991192e-19 NA NA NA hsa-let-7f-5p TGFBR3 -0.832261132545632 1.30765336262194e-16 1.47847669496634 9.50277769469809e-26 MirTarget -0.292672519047482 1.45101300167338e-06 NA NA NA hsa-let-7g-5p TGFBR3 -0.614367845078204 1.65972787509666e-17 1.47847669496634 9.50277769469809e-26 MirTarget -0.688684835018504 1.57932296664235e-16 NA NA NA hsa-miR-103a-3p TGFBR3 -1.20954748107199 5.62173682108288e-44 1.47847669496634 9.50277769469809e-26 MirTarget;miRNATAP -0.6996787899969 5.56360705975911e-28 NA NA NA hsa-miR-126-5p TGFBR3 -0.222731872217005 0.0500978215521652 1.47847669496634 9.50277769469809e-26 mirMAP -0.111409134773859 0.0456766998632486 NA NA NA hsa-miR-15a-5p TGFBR3 -0.922713188178759 6.51407511505147e-18 1.47847669496634 9.50277769469809e-26 MirTarget;miRNATAP -0.454358863446273 3.89682777741891e-16 NA NA NA hsa-miR-15b-5p TGFBR3 -0.902378373341059 1.52338978476144e-20 1.47847669496634 9.50277769469809e-26 MirTarget;miRNATAP -0.721093582954583 2.54814498021797e-34 NA NA NA hsa-miR-16-2-3p TGFBR3 -0.615426607127207 4.13943192730969e-05 1.47847669496634 9.50277769469809e-26 mirMAP -0.222611255046588 1.47394954070699e-07 NA NA NA hsa-miR-16-5p TGFBR3 -0.547308885680377 1.14657883125977e-10 1.47847669496634 9.50277769469809e-26 MirTarget;miRNATAP -0.43986081297257 1.41324316568957e-09 NA NA NA hsa-miR-182-5p TGFBR3 -2.57717136150549 4.94377928074908e-59 1.47847669496634 9.50277769469809e-26 miRNATAP -0.466482873355247 5.02620469256471e-47 NA NA NA hsa-miR-186-5p TGFBR3 -0.567811924899222 1.37607142180843e-13 1.47847669496634 9.50277769469809e-26 MirTarget -0.58903057337671 1.21603811421078e-13 NA NA NA hsa-miR-18a-5p TGFBR3 -1.25716708436839 5.1709808612863e-16 1.47847669496634 9.50277769469809e-26 MirTarget -0.313031744395967 4.75419369173149e-16 NA NA NA hsa-miR-193b-3p TGFBR3 -0.425830265253153 0.00142308830221877 1.47847669496634 9.50277769469809e-26 miRNAWalker2_validate;MirTarget;miRNATAP -0.124993769351845 0.00808137972021176 NA NA NA hsa-miR-195-3p TGFBR3 -0.598450619600341 1.01415597921415e-08 1.47847669496634 9.50277769469809e-26 mirMAP -0.18240337690411 0.00230811506184388 NA NA NA hsa-miR-21-5p TGFBR3 -1.03478217459823 8.05139001472981e-27 1.47847669496634 9.50277769469809e-26 miRNAWalker2_validate -0.540544955078126 3.99475127553857e-19 NA NA NA hsa-miR-29a-5p TGFBR3 -0.458517912323331 0.000412683536074951 1.47847669496634 9.50277769469809e-26 mirMAP -0.149568261310211 0.00201319012523939 NA NA NA hsa-miR-30b-5p TGFBR3 -1.16764575603669 1.75395013539893e-20 1.47847669496634 9.50277769469809e-26 mirMAP -0.461863271393037 2.50748087143685e-23 NA NA NA hsa-miR-30c-5p TGFBR3 -0.746747513281496 1.32431877874928e-12 1.47847669496634 9.50277769469809e-26 mirMAP -0.31458146039973 6.88345789970983e-08 NA NA NA hsa-miR-30d-5p TGFBR3 -0.804765144490435 1.42480384315577e-16 1.47847669496634 9.50277769469809e-26 mirMAP -0.568127300979921 1.24578316981394e-20 NA NA NA hsa-miR-30e-5p TGFBR3 0.0410434441382375 0.610918464525074 1.47847669496634 9.50277769469809e-26 mirMAP -0.217835666238863 0.00587757832443806 NA NA NA hsa-miR-335-3p TGFBR3 -0.625191833097363 1.64208673352814e-06 1.47847669496634 9.50277769469809e-26 mirMAP -0.396266624206323 1.91047809701543e-17 NA NA NA hsa-miR-339-5p TGFBR3 -0.986556478524229 2.39294233177812e-12 1.47847669496634 9.50277769469809e-26 miRanda -0.31712275813409 1.6783271237787e-13 NA NA NA hsa-miR-33a-3p TGFBR3 -0.612459021907227 0.000347410219059134 1.47847669496634 9.50277769469809e-26 mirMAP -0.282889082666094 1.16439077793228e-14 NA NA NA hsa-miR-340-5p TGFBR3 -0.418767158937088 8.44911569437027e-06 1.47847669496634 9.50277769469809e-26 mirMAP -0.227821534221774 0.000658194506689464 NA NA NA hsa-miR-34a-5p TGFBR3 -0.460660125860661 2.13400441654356e-06 1.47847669496634 9.50277769469809e-26 miRNATAP -0.171668164576105 0.00800155570451753 NA NA NA hsa-miR-3607-3p TGFBR3 -1.16606393006353 2.28951370382029e-07 1.47847669496634 9.50277769469809e-26 mirMAP -0.152447024664442 2.51086075014215e-08 NA NA NA hsa-miR-361-3p TGFBR3 -0.577270981783871 4.74678124050069e-11 1.47847669496634 9.50277769469809e-26 MirTarget;miRNATAP -0.153795281171575 0.0308340148623385 NA NA NA hsa-miR-361-5p TGFBR3 -0.652200980992921 2.23302456529972e-21 1.47847669496634 9.50277769469809e-26 miRanda -0.506544006778292 1.04382480906237e-08 NA NA NA hsa-miR-423-5p TGFBR3 -1.76013839591803 2.19994178835073e-44 1.47847669496634 9.50277769469809e-26 MirTarget -0.515058937881647 1.77829543344864e-32 NA NA NA hsa-miR-484 TGFBR3 -0.968911692345789 2.45789986401529e-17 1.47847669496634 9.50277769469809e-26 MirTarget;miRNATAP -0.445507778852401 1.14082099719179e-17 NA NA NA hsa-miR-497-5p TGFBR3 -0.424937624679997 8.43432731476464e-05 1.47847669496634 9.50277769469809e-26 MirTarget;miRNATAP -0.213917755260587 0.000232502088533411 NA NA NA hsa-miR-501-3p TGFBR3 -1.44481364651779 3.8180974374837e-26 1.47847669496634 9.50277769469809e-26 TargetScan;miRNATAP -0.310519582803989 6.91760631771834e-13 NA NA NA hsa-miR-582-5p TGFBR3 -0.306116891157888 0.0402663500947968 1.47847669496634 9.50277769469809e-26 mirMAP -0.10054012608966 0.0174889571708056 NA NA NA hsa-miR-590-3p TGFBR3 -0.58484153433625 1.6489232844135e-06 1.47847669496634 9.50277769469809e-26 MirTarget;miRanda;mirMAP -0.347648637114774 5.99723076076509e-12 NA NA NA hsa-miR-590-5p TGFBR3 -0.778106902153173 1.13576371947651e-09 1.47847669496634 9.50277769469809e-26 miRanda -0.352808955605778 1.35111665940415e-13 NA NA NA hsa-miR-7-1-3p TGFBR3 -1.45703750327525 1.75378847810364e-30 1.47847669496634 9.50277769469809e-26 mirMAP -0.55557378870648 9.90787001838823e-37 NA NA NA hsa-miR-375 THBS1 -3.07641574130359 1.01411669962478e-67 0.251186226004672 0.199305291838269 miRanda -0.165507749678643 5.95968419688133e-05 NA NA NA hsa-miR-375 THEMIS -3.07641574130359 1.01411669962478e-67 0.565945815245134 0.00892745426792416 miRanda -0.247905936975502 4.82836178758275e-08 NA NA NA hsa-miR-375 THRA -3.07641574130359 1.01411669962478e-67 0.514845612911693 5.37082261669435e-15 miRNAWalker2_validate -0.139336835649393 1.98255412655363e-24 NA NA NA hsa-miR-375 TLE4 -3.07641574130359 1.01411669962478e-67 0.462895652204116 0.000138861758744892 miRanda -0.186518590036808 1.6258800016962e-13 NA NA NA hsa-miR-375 TMC1 -3.07641574130359 1.01411669962478e-67 0.913280188212285 0.000606902087364302 miRanda -0.201879542283431 0.00035064200768866 NA NA NA hsa-miR-375 TMEFF1 -3.07641574130359 1.01411669962478e-67 0.584539780660139 2.17159020118856e-07 miRanda -0.104051021108075 1.43403260004012e-05 NA NA NA hsa-miR-375 TMEM106B -3.07641574130359 1.01411669962478e-67 0.669060858877676 9.37241052476057e-14 miRNAWalker2_validate -0.108867205881301 1.48511892068803e-08 NA NA NA hsa-miR-375 TMEM117 -3.07641574130359 1.01411669962478e-67 0.620862899792999 2.166903011207e-16 miRanda -0.152436874592366 5.56291924946783e-22 NA NA NA hsa-miR-222-5p TMEM45B 0.737345031279554 3.62982091679741e-08 -1.29716464529232 1.7932952021877e-07 MirTarget -0.42369477460737 9.61561986384239e-08 NA NA NA hsa-miR-29a-5p TMEM45B -0.458517912323331 0.000412683536074951 -1.29716464529232 1.7932952021877e-07 MirTarget -0.362471028103773 9.72881945321363e-06 NA NA NA hsa-miR-30a-3p TMEM45B 0.0513578942843456 0.646614247659862 -1.29716464529232 1.7932952021877e-07 MirTarget;miRNATAP -0.22483434965421 0.0195517435885946 NA NA NA hsa-miR-501-5p TMEM45B -0.0408475609966014 0.781958453157052 -1.29716464529232 1.7932952021877e-07 MirTarget -0.216918348224879 0.00362304079190146 NA NA NA hsa-miR-375 TMEM55A -3.07641574130359 1.01411669962478e-67 0.456742310912269 6.20997408549289e-06 miRNAWalker2_validate;miRanda -0.139930623384708 3.98585302035062e-11 NA NA NA hsa-miR-375 TNNI3K -3.07641574130359 1.01411669962478e-67 1.50466242433647 3.16600515296138e-16 miRanda -0.392432289971331 1.68166173160283e-24 NA NA NA hsa-miR-375 TNS3 -3.07641574130359 1.01411669962478e-67 0.262433305170612 0.0204567355455356 miRNAWalker2_validate -0.164048838512621 3.0927158057962e-12 NA NA NA hsa-miR-375 TOR1AIP2 -3.07641574130359 1.01411669962478e-67 0.650336842069766 2.5629457929061e-07 miRNAWalker2_validate -0.196715443896515 9.24732765885275e-14 NA NA NA hsa-miR-375 TPM1 -3.07641574130359 1.01411669962478e-67 1.3103201853165 1.33426017159486e-25 miRanda -0.365170481183688 1.1281192245652e-46 NA NA NA hsa-miR-125a-5p TRIB1 -0.0743450557019045 0.423845877863826 -1.46017673172155 3.53234881750571e-18 MirTarget;miRanda -0.256657008136788 0.00137228675413186 NA NA NA hsa-miR-125b-5p TRIB1 -0.0293874305780157 0.763949843010141 -1.46017673172155 3.53234881750571e-18 MirTarget -0.160108412999672 0.0359354684286433 NA NA NA hsa-miR-224-5p TRIB1 0.147176373443783 0.303231265283538 -1.46017673172155 3.53234881750571e-18 MirTarget -0.185036165876634 0.000362327020972903 24382668 MicroRNA 224 inhibits progression of human prostate cancer by downregulating TRIB1; In this study we identified TRIB1 as a target gene of miR-224; Forced expression of miR-224 suppressed PCa cell proliferation invasion and migration and promoted cell apoptosis by downregulating TRIB1; Moreover the expression level of miR-224 in PCa tissues was negatively correlated with that of TRIB1 miR-224 downregulation was frequently found in PCa tissues with metastasis higher PSA level and clinical stage whereas TRIB1 upregulation was significantly associated with metastasis; Both miR-224 downregulation and TRIB1 upregulation were significantly associated with poor biochemical recurrence-free survival of patients with PCa; In conclusion these findings reveal that the aberrant expression of miR-224 and TRIB1 may promote PCa progression and have potentials to serve as novel biomarkers for PCa prognosis progression;staging;metastasis;poor survival;recurrence;worse prognosis prostate cancer hsa-miR-23a-3p TRIB1 0.403368902936407 3.67910482846993e-06 -1.46017673172155 3.53234881750571e-18 MirTarget;miRNATAP -0.258591005673439 0.00231489314034003 NA NA NA hsa-miR-23b-3p TRIB1 0.601466385152159 1.2679337399541e-12 -1.46017673172155 3.53234881750571e-18 MirTarget;miRNATAP -0.55627819976358 5.60004090686233e-11 NA NA NA hsa-miR-330-3p TRIB1 0.648758240701829 1.73283773523948e-07 -1.46017673172155 3.53234881750571e-18 mirMAP -0.122723815218118 0.0402338098070784 NA NA NA hsa-miR-452-3p TRIB1 0.160736173909803 0.228583481808647 -1.46017673172155 3.53234881750571e-18 MirTarget -0.218074085364751 9.79981694466702e-05 NA NA NA hsa-miR-99a-5p TRIB1 0.152230182127974 0.171494306325442 -1.46017673172155 3.53234881750571e-18 miRNAWalker2_validate -0.172112571285187 0.010019041995269 NA NA NA hsa-miR-92b-3p TRIM36 -0.0515531008682384 0.658460162557115 -1.86912387059772 1.02284268691069e-42 MirTarget -0.240606853368763 8.72965902028586e-06 NA NA NA hsa-miR-375 TRIM6 -3.07641574130359 1.01411669962478e-67 1.45021668117377 2.27496587432269e-20 miRanda -0.46378847386824 1.68128793432206e-49 NA NA NA hsa-miR-375 TRIM9 -3.07641574130359 1.01411669962478e-67 1.91245558627314 9.22677801105075e-25 miRanda -0.614014312996286 2.84950872046671e-63 NA NA NA hsa-miR-375 TRPS1 -3.07641574130359 1.01411669962478e-67 0.725798096058237 6.49155197625938e-11 miRNATAP -0.224094333809355 1.95086025065583e-22 NA NA NA hsa-let-7a-3p TSHZ3 -0.885792199222571 4.41035630133324e-17 1.07461261558641 1.43346586843907e-18 MirTarget;miRNATAP -0.52845594613669 4.46116897678988e-29 NA NA NA hsa-let-7b-3p TSHZ3 -0.506893427781244 8.27914591468333e-08 1.07461261558641 1.43346586843907e-18 MirTarget;miRNATAP -0.362717204966595 7.98769795882122e-11 NA NA NA hsa-miR-106a-5p TSHZ3 -1.76751200862602 7.79031604495387e-24 1.07461261558641 1.43346586843907e-18 MirTarget;miRNATAP -0.247245200274709 3.74856925000087e-18 NA NA NA hsa-miR-106b-5p TSHZ3 -1.03194006819592 5.97693261279532e-24 1.07461261558641 1.43346586843907e-18 MirTarget;miRNATAP -0.457466129083318 7.47699245408272e-21 NA NA NA hsa-miR-126-5p TSHZ3 -0.222731872217005 0.0500978215521652 1.07461261558641 1.43346586843907e-18 MirTarget;miRNATAP -0.172858494191774 0.00026741059923728 NA NA NA hsa-miR-1301-3p TSHZ3 -1.04723166514282 1.08006888220124e-14 1.07461261558641 1.43346586843907e-18 MirTarget -0.273153022166912 7.06981647265477e-13 NA NA NA hsa-miR-141-3p TSHZ3 -1.79566520772936 2.43414267305203e-29 1.07461261558641 1.43346586843907e-18 MirTarget;TargetScan;miRNATAP -0.390968569281734 1.06912912191396e-39 NA NA NA hsa-miR-16-2-3p TSHZ3 -0.615426607127207 4.13943192730969e-05 1.07461261558641 1.43346586843907e-18 MirTarget;mirMAP -0.201955878097124 2.26188583453849e-08 NA NA NA hsa-miR-17-3p TSHZ3 -1.00900556864081 4.33187133364694e-23 1.07461261558641 1.43346586843907e-18 MirTarget;miRNATAP -0.407042219342159 2.01669823516536e-16 NA NA NA hsa-miR-17-5p TSHZ3 -1.75236465070226 3.95158641627966e-36 1.07461261558641 1.43346586843907e-18 MirTarget;TargetScan;miRNATAP -0.396671357542777 2.2787645515071e-31 NA NA NA hsa-miR-185-5p TSHZ3 -0.39710273539229 6.82630255342173e-06 1.07461261558641 1.43346586843907e-18 miRNATAP -0.178489288369321 0.00344355532739226 NA NA NA hsa-miR-18a-5p TSHZ3 -1.25716708436839 5.1709808612863e-16 1.07461261558641 1.43346586843907e-18 MirTarget;miRNATAP -0.239630180880943 4.84914163179977e-13 NA NA NA hsa-miR-19a-3p TSHZ3 -1.31708679186777 4.80964007387792e-14 1.07461261558641 1.43346586843907e-18 MirTarget;miRNATAP -0.231113749640938 3.43543365544646e-15 NA NA NA hsa-miR-19b-3p TSHZ3 -1.59390221063917 1.21812878827867e-26 1.07461261558641 1.43346586843907e-18 MirTarget;miRNATAP -0.34369447260607 1.2346856123279e-25 NA NA NA hsa-miR-20a-5p TSHZ3 -1.8613782696103 3.92351368893149e-34 1.07461261558641 1.43346586843907e-18 MirTarget;miRNATAP -0.345119466658301 4.62192714690559e-28 NA NA NA hsa-miR-20b-5p TSHZ3 -1.58314196476133 5.61327965534576e-17 1.07461261558641 1.43346586843907e-18 MirTarget;miRNATAP -0.226772889581186 2.95919085357649e-17 NA NA NA hsa-miR-21-5p TSHZ3 -1.03478217459823 8.05139001472981e-27 1.07461261558641 1.43346586843907e-18 miRNAWalker2_validate -0.386476667183451 1.41020350541131e-13 NA NA NA hsa-miR-25-3p TSHZ3 -1.48824362562015 5.9514552944435e-55 1.07461261558641 1.43346586843907e-18 miRNAWalker2_validate -0.615713069793252 2.72167912162644e-38 NA NA NA hsa-miR-30b-5p TSHZ3 -1.16764575603669 1.75395013539893e-20 1.07461261558641 1.43346586843907e-18 miRNAWalker2_validate -0.348473997142051 3.41540194062804e-18 NA NA NA hsa-miR-320a TSHZ3 -0.995486653328464 1.19389676663012e-20 1.07461261558641 1.43346586843907e-18 MirTarget;PITA;miRanda;miRNATAP -0.195892032674626 5.50642760908023e-05 NA NA NA hsa-miR-324-5p TSHZ3 -0.539970285576229 1.69955273262756e-05 1.07461261558641 1.43346586843907e-18 miRanda -0.215265986759361 3.7507316820238e-07 NA NA NA hsa-miR-335-3p TSHZ3 -0.625191833097363 1.64208673352814e-06 1.07461261558641 1.43346586843907e-18 MirTarget -0.216207639703757 1.03042894876391e-07 NA NA NA hsa-miR-33a-3p TSHZ3 -0.612459021907227 0.000347410219059134 1.07461261558641 1.43346586843907e-18 MirTarget -0.19438145036604 7.82977526062265e-10 NA NA NA hsa-miR-340-5p TSHZ3 -0.418767158937088 8.44911569437027e-06 1.07461261558641 1.43346586843907e-18 miRNATAP -0.248852163935286 1.23941807685315e-05 NA NA NA hsa-miR-375 TSHZ3 -3.07641574130359 1.01411669962478e-67 1.07461261558641 1.43346586843907e-18 miRanda -0.297014752236712 4.48522345194478e-32 NA NA NA hsa-miR-500a-3p TSHZ3 -1.50473282386435 1.6265335261465e-36 1.07461261558641 1.43346586843907e-18 MirTarget -0.346941423811616 2.90785536961851e-17 NA NA NA hsa-miR-501-3p TSHZ3 -1.44481364651779 3.8180974374837e-26 1.07461261558641 1.43346586843907e-18 MirTarget;PITA;TargetScan;miRNATAP -0.289253045131012 3.63660126453656e-15 NA NA NA hsa-miR-576-5p TSHZ3 -0.962105441345164 5.68435745070752e-14 1.07461261558641 1.43346586843907e-18 MirTarget;PITA -0.325846111909114 4.35956271340948e-16 NA NA NA hsa-miR-582-5p TSHZ3 -0.306116891157888 0.0402663500947968 1.07461261558641 1.43346586843907e-18 MirTarget;PITA;miRNATAP -0.117790706666978 0.00108935829962841 NA NA NA hsa-miR-590-3p TSHZ3 -0.58484153433625 1.6489232844135e-06 1.07461261558641 1.43346586843907e-18 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.229625308395331 1.34816262282632e-07 NA NA NA hsa-miR-590-5p TSHZ3 -0.778106902153173 1.13576371947651e-09 1.07461261558641 1.43346586843907e-18 PITA -0.249542185732173 1.21446824186881e-09 NA NA NA hsa-miR-7-1-3p TSHZ3 -1.45703750327525 1.75378847810364e-30 1.07461261558641 1.43346586843907e-18 mirMAP -0.421514218594726 2.03777484372131e-28 NA NA NA hsa-miR-93-5p TSHZ3 -2.02673564951393 4.11722430511061e-49 1.07461261558641 1.43346586843907e-18 MirTarget;miRNATAP -0.440427351645642 1.82944245142404e-40 NA NA NA hsa-let-7a-3p TSLP -0.885792199222571 4.41035630133324e-17 1.87015652186785 1.0617751875456e-19 MirTarget -0.916403905536613 1.02322413496215e-30 NA NA NA hsa-let-7b-3p TSLP -0.506893427781244 8.27914591468333e-08 1.87015652186785 1.0617751875456e-19 MirTarget -0.962850185479004 6.24970387806545e-26 NA NA NA hsa-let-7f-1-3p TSLP -0.159920578752557 0.190200799823397 1.87015652186785 1.0617751875456e-19 MirTarget -0.162344051882631 0.0318513293874279 NA NA NA hsa-miR-142-3p TSLP -0.668342567225765 0.000202408167795488 1.87015652186785 1.0617751875456e-19 miRanda -0.151661431114126 0.00258513442754507 NA NA NA hsa-miR-335-5p TSLP -0.960193718665197 5.23061119483484e-12 1.87015652186785 1.0617751875456e-19 miRNAWalker2_validate -0.269688369727725 2.44528670851975e-05 NA NA NA hsa-miR-33a-3p TSLP -0.612459021907227 0.000347410219059134 1.87015652186785 1.0617751875456e-19 mirMAP -0.3821969570451 6.08022938360587e-13 NA NA NA hsa-miR-340-5p TSLP -0.418767158937088 8.44911569437027e-06 1.87015652186785 1.0617751875456e-19 mirMAP -0.390622020936276 5.02758442028222e-05 NA NA NA hsa-miR-491-5p TSLP -0.996821208926168 6.43686029153545e-11 1.87015652186785 1.0617751875456e-19 miRanda -0.365628637263701 3.09326035177742e-10 NA NA NA hsa-miR-590-3p TSLP -0.58484153433625 1.6489232844135e-06 1.87015652186785 1.0617751875456e-19 miRanda;mirMAP -0.396834269736109 6.87827098974087e-08 NA NA NA hsa-miR-375 UGCG -3.07641574130359 1.01411669962478e-67 0.445088296523266 0.0326794185162656 miRNAWalker2_validate -0.131665390743289 0.00283318937905309 NA NA NA hsa-miR-375 UHMK1 -3.07641574130359 1.01411669962478e-67 1.04155057501693 4.91227023360166e-05 miRanda -0.270771680720366 5.87624777162629e-07 NA NA NA hsa-miR-375 USP53 -3.07641574130359 1.01411669962478e-67 0.539510676192561 1.00800711248494e-07 miRNATAP -0.175383372933395 8.48141288608246e-17 NA NA NA hsa-miR-375 UST -3.07641574130359 1.01411669962478e-67 0.906837169368319 5.83381428354428e-10 miRNATAP -0.246781243954789 8.45120206490204e-16 NA NA NA hsa-miR-375 VAT1L -3.07641574130359 1.01411669962478e-67 1.86355149475641 1.95212252274819e-11 miRNATAP -0.478438475842336 2.32973053200931e-16 NA NA NA hsa-miR-375 VMO1 -3.07641574130359 1.01411669962478e-67 0.414535439579014 0.0057428639564109 miRanda;miRNATAP -0.115524575667239 0.000272653977557449 NA NA NA hsa-miR-375 VWA5A -3.07641574130359 1.01411669962478e-67 1.44081372419969 2.22821415113936e-20 miRanda -0.46644901535519 5.4270849137504e-51 NA NA NA hsa-miR-375 WDR1 -3.07641574130359 1.01411669962478e-67 0.512684419346641 4.54353647531421e-26 miRNAWalker2_validate -0.15028083634269 2.30031134811843e-54 NA NA NA hsa-miR-199b-5p WIF1 -1.17761875205879 1.04905958983479e-17 2.82549403097486 2.38638399913895e-15 miRanda -0.265903553944954 0.0161207045255641 NA NA NA hsa-miR-320a WIF1 -0.995486653328464 1.19389676663012e-20 2.82549403097486 2.38638399913895e-15 miRanda -0.333156164942811 0.0187227662594468 NA NA NA hsa-miR-342-3p WIF1 -1.25856075011434 9.5039654565453e-34 2.82549403097486 2.38638399913895e-15 miRanda -0.5362277547152 0.000148122184272838 NA NA NA hsa-miR-361-5p WIF1 -0.652200980992921 2.23302456529972e-21 2.82549403097486 2.38638399913895e-15 miRanda -0.447038216442463 0.0444251189398917 NA NA NA hsa-miR-429 WIF1 -0.682420529994949 0.00462213397220848 2.82549403097486 2.38638399913895e-15 miRanda -0.162385163961549 0.0121891327217956 NA NA NA hsa-miR-590-3p WIF1 -0.58484153433625 1.6489232844135e-06 2.82549403097486 2.38638399913895e-15 PITA;miRanda;mirMAP -0.660936437074725 1.7327861475057e-07 NA NA NA hsa-miR-375 WIPF3 -3.07641574130359 1.01411669962478e-67 1.02327076027115 4.92083544562548e-09 miRanda -0.341560797315298 3.74543631618161e-21 NA NA NA hsa-miR-375 WNT5A -3.07641574130359 1.01411669962478e-67 0.520464630194533 0.0131262440505623 miRNATAP -0.105427475280484 0.0178656607262494 NA NA NA hsa-miR-375 WWC2 -3.07641574130359 1.01411669962478e-67 0.689498311891516 5.90928233774285e-09 miRNAWalker2_validate;miRNATAP -0.166457509507954 2.72566602517987e-11 NA NA NA hsa-miR-375 XAF1 -3.07641574130359 1.01411669962478e-67 0.433223908222542 0.00822347448546174 MirTarget;miRanda -0.222844854917197 7.2351035171971e-11 NA NA NA hsa-miR-375 XPR1 -3.07641574130359 1.01411669962478e-67 0.287880896719611 2.64511379562009e-05 miRNAWalker2_validate -0.111837246237096 3.40106644475405e-15 NA NA NA hsa-miR-375 YAP1 -3.07641574130359 1.01411669962478e-67 0.887455346158598 2.09965826835664e-21 miRNAWalker2_validate;miRTarBase;miRNATAP -0.26023178976251 6.24526767300284e-43 27270433;23685355;20226166;21856745 A ZEB1 miR 375 YAP1 pathway regulates epithelial plasticity in prostate cancer; The transcription factor YAP1 was found to be a direct target of miR-375 in prostate cancer; Knockdown of YAP1 phenocopied miR-375 overexpression and overexpression of YAP1 rescued anti-invasive effects mediated by miR-375;Overexpression of miR 10a and miR 375 and downregulation of YAP1 in medullary thyroid carcinoma; Expression of the potential downstream targets of miR-375 YAP1 a growth inhibitor and SLC16a2 a transporter of thyroid hormone was down-regulated in the tumors suggesting that miR-375 is a negative regulator of the expression of these genes; Furthermore the growth inhibitor YAP1 is identified as a potential important downstream target of miR-375;MicroRNA 375 targets Hippo signaling effector YAP in liver cancer and inhibits tumor properties; The present study aims to elucidate the transcriptional regulation of YAP targeted by microRNA miRNA miR-375 is a putative target and was found significantly down-regulated in the tumor versus adjacent non-tumor tissues of HCC patients n=48; As determined by luciferase reporter assay we found ectopic expression of miR-375 could diminish the transcriptional activity of YAP; Furthermore immunoblotting revealed miR-375 suppressed endogenous YAP protein level; miR-375 is an important regulator of YAP oncogene implicating a potential therapeutic role in HCC treatment;miR 375 is activated by ASH1 and inhibits YAP1 in a lineage dependent manner in lung cancer; The transcriptional coactivator YAP1 was determined to be a direct target of miR-375; YAP1 showed a negative correlation with miR-375 in a panel of lung cancer cell lines and growth inhibitory activities in NE-lung cancer cells ;;; prostate cancer;thyroid cancer;liver cancer;lung cancer hsa-miR-375 ZBTB20 -3.07641574130359 1.01411669962478e-67 1.04340736298259 1.03423786093513e-09 miRanda -0.231395802269283 1.60905578591853e-10 NA NA NA hsa-miR-375 ZCCHC12 -3.07641574130359 1.01411669962478e-67 1.40933644932037 2.2100202696814e-11 miRanda -0.444489890672375 1.57870615372806e-24 NA NA NA hsa-miR-375 ZEB1 -3.07641574130359 1.01411669962478e-67 0.989361063782148 7.82636251530039e-14 miRanda -0.336263153514774 4.7816484583309e-36 27270433 A ZEB1 miR 375 YAP1 pathway regulates epithelial plasticity in prostate cancer; Furthermore transcription of the miR-375 gene was shown to be directly repressed by the EMT transcription factor ZEB1 prostate cancer hsa-miR-375 ZEB2 -3.07641574130359 1.01411669962478e-67 1.07921538189311 1.12726183087808e-12 miRanda -0.344520936631933 1.92378297164947e-28 NA NA NA hsa-miR-375 ZFHX4 -3.07641574130359 1.01411669962478e-67 0.572695352020306 0.00293589439899295 miRanda;miRNATAP -0.296200742736959 1.28522713357713e-13 NA NA NA hsa-miR-375 ZFP36L2 -3.07641574130359 1.01411669962478e-67 0.624312208778523 1.89568962213356e-07 miRNAWalker2_validate;miRanda -0.230366980392858 1.19004703093534e-20 NA NA NA hsa-miR-375 ZFPM2 -3.07641574130359 1.01411669962478e-67 1.47503430315066 8.88325469489316e-13 miRanda -0.497835396743899 2.56245449921993e-32 NA NA NA hsa-miR-326 ZNF577 0.893385784609657 5.72581663211201e-08 -0.688506334059755 5.28948760650258e-12 MirTarget;miRanda -0.121524558082488 3.22399554094403e-06 NA NA NA hsa-miR-330-5p ZNF577 0.493301557454586 1.71135028785129e-05 -0.688506334059755 5.28948760650258e-12 MirTarget;miRanda -0.273022643676738 1.3719997221594e-13 NA NA NA hsa-miR-375 ZYG11B -3.07641574130359 1.01411669962478e-67 0.457140536420849 2.12289083588322e-12 miRanda -0.104836334118362 1.97526030818877e-14 NA NA NA