miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-3p APC 0.82512001802525 0.0468122405194487 -0.0767747610151472 0.842336162144662 mirMAP -0.118992251982524 0.0251702207786024 NA NA NA hsa-let-7f-1-3p APC 1.61507869803314 0.00069342464777815 -0.0767747610151472 0.842336162144662 mirMAP -0.106061888173804 0.0212797848699551 NA NA NA hsa-miR-186-5p APC 0.445443449112564 0.185447310527704 -0.0767747610151472 0.842336162144662 miRNAWalker2_validate -0.186375765100707 0.00487494868289952 NA NA NA hsa-miR-193a-3p APC 0.646392169474854 0.207134343676122 -0.0767747610151472 0.842336162144662 miRanda -0.102910772792179 0.016272334248772 NA NA NA hsa-miR-30a-3p APC -1.22212086897848 0.167565797592104 -0.0767747610151472 0.842336162144662 MirTarget;miRNATAP -0.110308714220782 5.55003156650705e-06 NA NA NA hsa-miR-30e-3p APC -0.0362193022195196 0.932577027239525 -0.0767747610151472 0.842336162144662 MirTarget -0.117014973413551 0.0234367131954567 NA NA NA hsa-miR-320a APC -0.912036444869976 0.0565555443926988 -0.0767747610151472 0.842336162144662 miRanda -0.105439498385919 0.0216305061378486 NA NA NA hsa-miR-320b APC 0.20205459771295 0.727216419960509 -0.0767747610151472 0.842336162144662 miRanda -0.120780596736221 0.00135470702580849 NA NA NA hsa-miR-374b-5p APC -0.114749866169918 0.764888930049438 -0.0767747610151472 0.842336162144662 mirMAP -0.185591036709671 0.00127655314359827 NA NA NA hsa-miR-590-3p APC 2.35429565068338 2.79601879608564e-06 -0.0767747610151472 0.842336162144662 PITA;miRanda;mirMAP;miRNATAP -0.166334795891123 9.61904390448028e-05 NA NA NA hsa-miR-7-1-3p APC 1.43074343339835 0.00471215970502094 -0.0767747610151472 0.842336162144662 MirTarget -0.147209385006141 0.000605238293641448 NA NA NA hsa-miR-125a-5p APC2 -1.32352790615388 0.00714301627309467 3.13191261662562 0.00737055129114406 mirMAP -0.853096269997355 1.04500045510591e-10 NA NA NA hsa-miR-194-3p APC2 1.91743783341496 0.105383373371284 3.13191261662562 0.00737055129114406 mirMAP -0.158439963257808 0.00506903391988806 NA NA NA hsa-miR-28-5p APC2 -0.815636722979196 0.0221199948901761 3.13191261662562 0.00737055129114406 mirMAP -0.665871134811181 0.000433374657967794 NA NA NA hsa-miR-625-5p APC2 2.02792641909347 0.000935142379948297 3.13191261662562 0.00737055129114406 mirMAP -0.259059293372713 0.0176749358928683 NA NA NA hsa-let-7a-3p AXIN2 0.82512001802525 0.0468122405194487 -3.82407466660445 0.000332783445696398 miRNATAP -0.494045855852835 0.000853130932920837 NA NA NA hsa-let-7b-3p AXIN2 0.589364128513318 0.200507534602851 -3.82407466660445 0.000332783445696398 miRNATAP -0.497070558406417 0.000186469770166558 NA NA NA hsa-let-7f-2-3p AXIN2 1.02768112108475 0.0787293499732611 -3.82407466660445 0.000332783445696398 MirTarget -0.356438400092079 0.000841906314096363 NA NA NA hsa-miR-15a-5p AXIN2 2.0535411006904 1.91108976398046e-06 -3.82407466660445 0.000332783445696398 MirTarget;miRNATAP -0.550942102635856 8.04479638813504e-05 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy thyroid cancer hsa-miR-15b-5p AXIN2 3.32329949959268 8.40210501034588e-13 -3.82407466660445 0.000332783445696398 miRTarBase;MirTarget;miRNATAP -0.467609074192871 0.00022236000942262 NA NA NA hsa-miR-16-2-3p AXIN2 3.79845098071094 1.49120139344659e-13 -3.82407466660445 0.000332783445696398 mirMAP -0.6823456604213 9.95304651839219e-10 NA NA NA hsa-miR-16-5p AXIN2 2.93575808220754 2.15436817162977e-10 -3.82407466660445 0.000332783445696398 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.695908366314422 3.93881990567234e-08 NA NA NA hsa-miR-205-5p AXIN2 8.08298115900323 3.83045179398654e-07 -3.82407466660445 0.000332783445696398 miRNATAP -0.296107118342617 9.25850565228752e-17 NA NA NA hsa-miR-221-3p AXIN2 0.94082283577318 0.174749164179978 -3.82407466660445 0.000332783445696398 miRNATAP -0.518384723281925 1.67647878628316e-09 NA NA NA hsa-miR-222-3p AXIN2 1.54730827524553 0.0223014220569407 -3.82407466660445 0.000332783445696398 miRNATAP -0.534987790682349 1.10747648966591e-09 NA NA NA hsa-miR-3614-5p AXIN2 4.50236405439456 2.75644515847367e-07 -3.82407466660445 0.000332783445696398 MirTarget;miRNATAP -0.261864275832248 0.000119330708648269 NA NA NA hsa-miR-590-3p AXIN2 2.35429565068338 2.79601879608564e-06 -3.82407466660445 0.000332783445696398 MirTarget;PITA;miRanda;miRNATAP -0.500291647228716 2.7183686924642e-05 NA NA NA hsa-miR-944 AXIN2 7.20925181386398 0.000823207457340648 -3.82407466660445 0.000332783445696398 MirTarget;PITA;miRNATAP -0.276130498452101 8.40746733798985e-17 NA NA NA hsa-let-7e-5p BTRC -0.111012524740586 0.814744515884005 -0.389242677076138 0.229517873289865 miRNAWalker2_validate -0.157958876446546 4.3321742453e-05 NA NA NA hsa-miR-125a-3p BTRC -0.0748960586927341 0.920735897434087 -0.389242677076138 0.229517873289865 miRanda -0.111382995850356 3.64944935788154e-06 NA NA NA hsa-miR-15a-5p BTRC 2.0535411006904 1.91108976398046e-06 -0.389242677076138 0.229517873289865 miRNAWalker2_validate;MirTarget;miRNATAP -0.107352634887892 0.0108452097639089 NA NA NA hsa-miR-15b-5p BTRC 3.32329949959268 8.40210501034588e-13 -0.389242677076138 0.229517873289865 MirTarget;miRNATAP -0.14366136035681 0.000149866518688636 NA NA NA hsa-miR-16-5p BTRC 2.93575808220754 2.15436817162977e-10 -0.389242677076138 0.229517873289865 miRNAWalker2_validate;MirTarget;miRNATAP -0.130265266499023 0.000715839459970842 NA NA NA hsa-miR-186-5p BTRC 0.445443449112564 0.185447310527704 -0.389242677076138 0.229517873289865 mirMAP -0.11201317622676 0.044292445265588 NA NA NA hsa-miR-28-5p BTRC -0.815636722979196 0.0221199948901761 -0.389242677076138 0.229517873289865 miRanda -0.236608660977103 4.38097837138535e-06 NA NA NA hsa-miR-339-5p BTRC 1.23326828594484 0.0307501214818698 -0.389242677076138 0.229517873289865 MirTarget;miRanda -0.105080246885308 0.00100529890713538 NA NA NA hsa-miR-3913-5p BTRC 0.145645056779437 0.734844256690741 -0.389242677076138 0.229517873289865 mirMAP -0.160514640592341 0.000175552950437538 NA NA NA hsa-miR-505-3p BTRC 0.58881333170866 0.226937454637888 -0.389242677076138 0.229517873289865 MirTarget -0.103932436230113 0.00591974191859582 NA NA NA hsa-miR-10a-5p CAMK2A -0.482300926520507 0.594608783320466 -4.61067365401457 0.000101073851621997 mirMAP -0.420794719642766 1.01305937838495e-08 NA NA NA hsa-miR-130b-5p CAMK2A 3.74118449312296 2.92266550966038e-10 -4.61067365401457 0.000101073851621997 mirMAP -0.55410496328163 4.56734557457472e-07 NA NA NA hsa-miR-148b-5p CAMK2A 2.80812018666078 3.97536665756679e-08 -4.61067365401457 0.000101073851621997 mirMAP -0.36341828117092 0.00552462088359509 NA NA NA hsa-miR-15b-3p CAMK2A 3.57530146629867 5.89922785773482e-11 -4.61067365401457 0.000101073851621997 mirMAP -0.371629816235669 0.00210186189548789 NA NA NA hsa-miR-19b-1-5p CAMK2A 1.51335451095424 0.0014717605268143 -4.61067365401457 0.000101073851621997 mirMAP -0.384132315859022 0.00728267982533681 NA NA NA hsa-miR-25-3p CAMK2A 1.12623030168869 0.00311079344417173 -4.61067365401457 0.000101073851621997 MirTarget -0.822145181684791 4.06664429175661e-06 NA NA NA hsa-miR-30a-5p CAMK2A -0.768430903969183 0.320487552854215 -4.61067365401457 0.000101073851621997 mirMAP -0.256941624107436 0.00344554944097223 NA NA NA hsa-miR-30c-5p CAMK2A 0.38723991118075 0.348605235643473 -4.61067365401457 0.000101073851621997 mirMAP -0.355925675010254 0.0333528453998966 NA NA NA hsa-miR-30d-5p CAMK2A 0.302504510257496 0.380193536606962 -4.61067365401457 0.000101073851621997 mirMAP -0.781249742477655 9.72613411407572e-05 NA NA NA hsa-miR-30e-5p CAMK2A 0.780047227271616 0.0346714425913016 -4.61067365401457 0.000101073851621997 mirMAP -0.492300827566032 0.00851183958796349 NA NA NA hsa-miR-32-5p CAMK2A 2.93035124381469 5.00149131394151e-10 -4.61067365401457 0.000101073851621997 MirTarget -0.383335742869611 0.00665637714187399 NA NA NA hsa-miR-331-3p CAMK2A 2.60769294751513 3.84318952029483e-07 -4.61067365401457 0.000101073851621997 MirTarget -0.306663715637232 0.0190969548463272 NA NA NA hsa-miR-335-5p CAMK2A 0.167216045757305 0.803897055331049 -4.61067365401457 0.000101073851621997 mirMAP -0.229582338682613 0.0236080567417352 NA NA NA hsa-miR-338-3p CAMK2A 0.447551118940466 0.558485097370031 -4.61067365401457 0.000101073851621997 miRNATAP -0.265862011396483 0.002771828861227 NA NA NA hsa-miR-361-3p CAMK2A 0.805698609170807 0.0418491665498322 -4.61067365401457 0.000101073851621997 mirMAP -0.683138676080587 7.7163226253072e-05 NA NA NA hsa-miR-363-3p CAMK2A 4.27232887548977 8.53979362839458e-06 -4.61067365401457 0.000101073851621997 MirTarget -0.421857173981953 5.69198336143035e-10 NA NA NA hsa-miR-3913-5p CAMK2A 0.145645056779437 0.734844256690741 -4.61067365401457 0.000101073851621997 mirMAP -0.460766430743198 0.00399783001682156 NA NA NA hsa-miR-429 CAMK2A 6.39965293994036 1.96920201593608e-18 -4.61067365401457 0.000101073851621997 miRNATAP -0.599892636704134 1.46991676363009e-12 NA NA NA hsa-miR-616-5p CAMK2A 2.48416313933027 0.00318247475868827 -4.61067365401457 0.000101073851621997 mirMAP -0.436573204673853 1.21047015450171e-05 NA NA NA hsa-miR-625-5p CAMK2A 2.02792641909347 0.000935142379948297 -4.61067365401457 0.000101073851621997 mirMAP -0.458078810299952 3.37229664293953e-05 NA NA NA hsa-miR-7-1-3p CAMK2A 1.43074343339835 0.00471215970502094 -4.61067365401457 0.000101073851621997 MirTarget -0.370795412070839 0.00584126162476116 NA NA NA hsa-miR-92a-3p CAMK2A 1.87892405805529 1.27013821556583e-05 -4.61067365401457 0.000101073851621997 MirTarget -0.41072175784963 0.00917518238950801 NA NA NA hsa-miR-92b-3p CAMK2A 1.69303761469782 0.0103484911955574 -4.61067365401457 0.000101073851621997 MirTarget -0.455330197705722 7.54835153632853e-06 NA NA NA hsa-miR-140-3p CAMK2B -1.9828800596692 8.92876132959514e-08 1.67147225416157 0.24792776697611 mirMAP -0.453766065444575 0.0398956522243766 NA NA NA hsa-miR-29a-3p CAMK2B -0.638239697975974 0.251923581881716 1.67147225416157 0.24792776697611 mirMAP -0.45802934441659 0.00193384833829684 NA NA NA hsa-miR-29b-3p CAMK2B 0.666547117072858 0.234055379278093 1.67147225416157 0.24792776697611 mirMAP -0.451563574061045 0.00211633631251574 NA NA NA hsa-miR-29c-3p CAMK2B -0.414153610337085 0.529344128062017 1.67147225416157 0.24792776697611 mirMAP -0.272811671842176 0.0293575369490243 NA NA NA hsa-miR-139-5p CAMK2D -2.09475477693654 0.000382570602748311 -0.436236695859307 0.415730908577409 PITA;miRanda -0.170076594620179 0.000849556884477263 NA NA NA hsa-miR-17-3p CAMK2D 1.2477858204856 0.00186593270231258 -0.436236695859307 0.415730908577409 miRNATAP -0.163969901290336 0.0317422413532409 NA NA NA hsa-miR-186-5p CAMK2D 0.445443449112564 0.185447310527704 -0.436236695859307 0.415730908577409 mirMAP -0.235203354069237 0.0108245576227184 NA NA NA hsa-miR-197-3p CAMK2D 1.23723883665376 0.0073292027020411 -0.436236695859307 0.415730908577409 miRNATAP -0.198412063891944 0.00262366830550097 NA NA NA hsa-miR-217 CAMK2D -0.378397407994341 0.717408682071252 -0.436236695859307 0.415730908577409 miRanda -0.1026380481751 0.000406136865826072 NA NA NA hsa-miR-27a-3p CAMK2D 1.76094007417453 0.000216137556256765 -0.436236695859307 0.415730908577409 miRNATAP -0.183195442053396 0.0039502081301884 NA NA NA hsa-miR-30a-5p CAMK2D -0.768430903969183 0.320487552854215 -0.436236695859307 0.415730908577409 miRNATAP -0.10893303041019 0.00545078826629344 NA NA NA hsa-miR-30b-5p CAMK2D 0.0238659735605804 0.953223658270319 -0.436236695859307 0.415730908577409 miRNATAP -0.209196435811538 0.00568550193602901 NA NA NA hsa-miR-30c-5p CAMK2D 0.38723991118075 0.348605235643473 -0.436236695859307 0.415730908577409 miRNATAP -0.211788022743028 0.00440299858375001 NA NA NA hsa-miR-32-3p CAMK2D 2.20477794939766 0.0392771274032852 -0.436236695859307 0.415730908577409 mirMAP -0.204158627980238 3.79938884300681e-05 NA NA NA hsa-miR-320b CAMK2D 0.20205459771295 0.727216419960509 -0.436236695859307 0.415730908577409 miRanda -0.137284767408159 0.00910680545026566 NA NA NA hsa-miR-320c CAMK2D -0.10618808730545 0.854002814666472 -0.436236695859307 0.415730908577409 miRanda -0.116603474417516 0.0305851381925504 NA NA NA hsa-miR-342-3p CAMK2D 1.31107714473009 0.0207211910724662 -0.436236695859307 0.415730908577409 miRanda -0.129151418529387 0.01603122179091 NA NA NA hsa-miR-484 CAMK2D 1.79050445056016 0.000217287101253701 -0.436236695859307 0.415730908577409 miRNAWalker2_validate -0.185983159125907 0.00289263237335324 NA NA NA hsa-miR-582-5p CAMK2D 0.685177900016753 0.447761540297692 -0.436236695859307 0.415730908577409 mirMAP -0.215531600574554 3.79586190267961e-11 NA NA NA hsa-miR-590-3p CAMK2D 2.35429565068338 2.79601879608564e-06 -0.436236695859307 0.415730908577409 miRanda;mirMAP -0.13948831086374 0.0198019055403196 NA NA NA hsa-miR-107 CAMK2G 1.49443409571439 0.000130594521065411 -0.697211520072334 0.0283570720291188 miRNATAP -0.120868237018994 0.00894743846200391 NA NA NA hsa-miR-181a-5p CAMK2G 1.25558293560636 0.00748975499703878 -0.697211520072334 0.0283570720291188 miRNATAP -0.176433766908084 3.44432421400082e-06 NA NA NA hsa-miR-181b-5p CAMK2G 1.11397227523501 0.0273417050354018 -0.697211520072334 0.0283570720291188 miRNATAP -0.184358369729924 1.59425088906457e-07 NA NA NA hsa-miR-181c-5p CAMK2G -0.302833440762172 0.537532549455539 -0.697211520072334 0.0283570720291188 miRNATAP -0.134228962152357 0.000257447525525637 NA NA NA hsa-miR-484 CAMK2G 1.79050445056016 0.000217287101253701 -0.697211520072334 0.0283570720291188 mirMAP -0.107696026923104 0.00362026376984953 NA NA NA hsa-miR-628-5p CAMK2G 1.04832355434705 0.0252368809675445 -0.697211520072334 0.0283570720291188 MirTarget;PITA;miRNATAP -0.174490124142303 5.05586268618289e-06 NA NA NA hsa-let-7a-5p CCND1 0.148081801547773 0.645305441523746 0.153161422157864 0.87752763573474 TargetScan;miRNATAP -0.543758028087025 0.00245174452713361 NA NA NA hsa-let-7b-5p CCND1 -0.189422992330471 0.651878220048983 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;miRNATAP -0.332373627174734 0.0145885281476206 18379589;23162627 The effect of let-7b on protein expression was due to targeting of 3'-untranslated regions 3'UTRs of individual mRNAs as exemplified by reporter gene analyses for cyclin D1;Cyclin D1 expression was significantly higher in cells transfected with let-7b plasmid and let-7b inhibitor compared with control cells P<0.05 ; melanoma;melanoma hsa-miR-106a-5p CCND1 3.98693608217557 9.37722470816656e-07 0.153161422157864 0.87752763573474 MirTarget;miRNATAP -0.430943892321887 6.82894757639655e-11 NA NA NA hsa-miR-15a-5p CCND1 2.0535411006904 1.91108976398046e-06 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.345671894500985 0.00776019225008181 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-15b-5p CCND1 3.32329949959268 8.40210501034588e-13 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.423468924188888 0.000292921876666624 NA NA NA hsa-miR-16-1-3p CCND1 2.83281226969693 7.54359864580834e-09 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase -0.275720958970172 0.0145820806306852 22922827;18483394 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ; sarcoma;lymphoma hsa-miR-16-5p CCND1 2.93575808220754 2.15436817162977e-10 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.284916261699172 0.0168773058026141 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-195-5p CCND1 -1.59182537400701 0.0169128463756769 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.179900970878552 0.0332727802012022 26631043;21350001;25823925 MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma ;;metastasis;poor survival cervical and endocervical cancer;breast cancer;sarcoma hsa-miR-20b-5p CCND1 4.5662923200279 4.75238200639144e-05 0.153161422157864 0.87752763573474 MirTarget;miRNATAP -0.306916825629866 1.73283870424345e-10 NA NA NA hsa-miR-34a-5p CCND1 0.830377770217786 0.0477544831885907 0.153161422157864 0.87752763573474 miRNAWalker2_validate;miRTarBase;miRNATAP -0.423813778518534 0.00174350326234822 25792709;21399894 This inhibition of proliferation was associated with a decrease in cyclin D1 levels orchestrated principally by HNF-4α a target of miR-34a considered to act as a tumour suppressor in the liver;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a ; liver cancer;breast cancer hsa-miR-497-5p CCND1 -1.44150596209372 0.0225146607606395 0.153161422157864 0.87752763573474 MirTarget;miRNATAP -0.249933846887954 0.00498383887238102 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-let-7b-5p CCND2 -0.189422992330471 0.651878220048983 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate;miRTarBase;miRNATAP -0.270151809296289 0.0262211916765442 NA NA NA hsa-miR-106a-5p CCND2 3.98693608217557 9.37722470816656e-07 -2.81051675901102 0.00139983736368543 miRNATAP -0.444958981451041 2.08537025757115e-14 NA NA NA hsa-miR-106b-5p CCND2 2.80565545918114 1.14547999022566e-09 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309595760343179 0.00374413339981401 NA NA NA hsa-miR-10a-3p CCND2 0.970411431936568 0.31667483998251 -2.81051675901102 0.00139983736368543 mirMAP -0.203238239783698 0.000109626077062705 NA NA NA hsa-miR-130b-5p CCND2 3.74118449312296 2.92266550966038e-10 -2.81051675901102 0.00139983736368543 mirMAP -0.460499923117218 1.14695292180331e-08 NA NA NA hsa-miR-141-3p CCND2 7.30474126597325 1.45115996357606e-24 -2.81051675901102 0.00139983736368543 MirTarget;TargetScan -0.239696704303332 0.000205435786708848 NA NA NA hsa-miR-151a-3p CCND2 0.373902859770645 0.376924505912903 -2.81051675901102 0.00139983736368543 mirMAP -0.249893063610577 0.0381794771362485 NA NA NA hsa-miR-15a-5p CCND2 2.0535411006904 1.91108976398046e-06 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265897810726786 0.0219268117713828 NA NA NA hsa-miR-15b-5p CCND2 3.32329949959268 8.40210501034588e-13 -2.81051675901102 0.00139983736368543 miRNATAP -0.527059068245043 3.31921597840683e-07 NA NA NA hsa-miR-16-2-3p CCND2 3.79845098071094 1.49120139344659e-13 -2.81051675901102 0.00139983736368543 mirMAP -0.289719520581 0.00206680066165107 NA NA NA hsa-miR-16-5p CCND2 2.93575808220754 2.15436817162977e-10 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate;miRNATAP -0.251146139120174 0.0182715478356435 NA NA NA hsa-miR-182-5p CCND2 5.86988712704738 1.22411588571584e-15 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate;miRTarBase;miRNATAP -0.278474368736704 1.61949004264047e-05 NA NA NA hsa-miR-183-5p CCND2 6.61903249270777 1.00958881445636e-16 -2.81051675901102 0.00139983736368543 miRNATAP -0.288028240113034 1.0097840608077e-06 NA NA NA hsa-miR-191-5p CCND2 1.58824208483839 0.000738859004053681 -2.81051675901102 0.00139983736368543 MirTarget -0.315151097931825 0.00313941450228982 NA NA NA hsa-miR-200a-3p CCND2 6.336081120041 4.024313571871e-16 -2.81051675901102 0.00139983736368543 MirTarget -0.414829241668513 2.52639559759353e-12 NA NA NA hsa-miR-20b-5p CCND2 4.5662923200279 4.75238200639144e-05 -2.81051675901102 0.00139983736368543 miRNATAP -0.295383995634395 4.37719472717441e-12 NA NA NA hsa-miR-224-3p CCND2 2.84876340814503 0.000179138399939161 -2.81051675901102 0.00139983736368543 mirMAP -0.216162489376406 0.00100829595274067 NA NA NA hsa-miR-28-5p CCND2 -0.815636722979196 0.0221199948901761 -2.81051675901102 0.00139983736368543 miRanda -0.428938814049462 0.00272604774130058 NA NA NA hsa-miR-3065-3p CCND2 1.89496019576082 0.0308154823923145 -2.81051675901102 0.00139983736368543 MirTarget;miRNATAP -0.206941274598462 0.000265009133802388 NA NA NA hsa-miR-3065-5p CCND2 2.14185373842821 0.0609400502269891 -2.81051675901102 0.00139983736368543 mirMAP -0.198616424838265 0.000257635954140166 NA NA NA hsa-miR-30d-3p CCND2 -0.0740421896025512 0.857423650167556 -2.81051675901102 0.00139983736368543 mirMAP -0.548341190913964 7.47249707616609e-06 NA NA NA hsa-miR-324-3p CCND2 1.51345381556672 0.0038447546677657 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate -0.43719832262749 4.09891269304966e-06 NA NA NA hsa-miR-33a-3p CCND2 2.06269680799532 0.00156436055383943 -2.81051675901102 0.00139983736368543 MirTarget -0.270924955791957 0.000410846654094401 NA NA NA hsa-miR-3607-3p CCND2 1.38015131722213 0.0240067155694847 -2.81051675901102 0.00139983736368543 mirMAP -0.186544272191961 0.0234028956529654 NA NA NA hsa-miR-378a-3p CCND2 1.46612141870273 0.0466660641196872 -2.81051675901102 0.00139983736368543 miRNAWalker2_validate -0.186901666998984 0.00600686499792038 NA NA NA hsa-miR-429 CCND2 6.39965293994036 1.96920201593608e-18 -2.81051675901102 0.00139983736368543 miRNATAP -0.457780562605429 2.24817157133262e-13 NA NA NA hsa-miR-497-5p CCND2 -1.44150596209372 0.0225146607606395 -2.81051675901102 0.00139983736368543 MirTarget;miRNATAP -0.272420525595686 0.000579324260115001 NA NA NA hsa-miR-501-5p CCND2 1.0411896821345 0.0777206709183552 -2.81051675901102 0.00139983736368543 PITA;mirMAP;miRNATAP -0.16857726291091 0.0487498086832838 NA NA NA hsa-miR-550a-5p CCND2 1.21781238856895 0.0613791144699551 -2.81051675901102 0.00139983736368543 MirTarget -0.224646283844048 0.00363403467531415 NA NA NA hsa-miR-660-5p CCND2 -0.0668683798854808 0.885250178390404 -2.81051675901102 0.00139983736368543 mirMAP -0.290960137515711 0.00793054638018279 NA NA NA hsa-miR-9-3p CCND2 1.69328215716742 0.125170982657059 -2.81051675901102 0.00139983736368543 MirTarget;mirMAP;miRNATAP -0.143162485603445 0.00185116011719342 NA NA NA hsa-miR-93-5p CCND2 2.65964181833033 2.58315947526774e-08 -2.81051675901102 0.00139983736368543 miRNATAP -0.48060449639845 2.62594110203289e-06 NA NA NA hsa-miR-96-5p CCND2 5.62521466029286 1.54938806718028e-10 -2.81051675901102 0.00139983736368543 TargetScan;miRNATAP -0.24395409924335 0.000303822796805944 NA NA NA hsa-miR-27b-3p CCND3 -0.0929089601968123 0.85847352206581 -0.53759657598867 0.124370433214632 miRNAWalker2_validate -0.141758210053908 0.000190546260809965 NA NA NA hsa-miR-429 CCND3 6.39965293994036 1.96920201593608e-18 -0.53759657598867 0.124370433214632 miRNATAP -0.112877673525875 7.62633278325715e-06 NA NA NA hsa-miR-96-5p CCND3 5.62521466029286 1.54938806718028e-10 -0.53759657598867 0.124370433214632 TargetScan -0.116905111437921 9.66017245986979e-06 NA NA NA hsa-miR-103a-3p CD274 0.990919087251708 0.00468308601422847 2.22279412449515 0.0516111370736547 miRNAWalker2_validate -0.483901377020577 0.010127083096146 NA NA NA hsa-miR-106a-5p CD274 3.98693608217557 9.37722470816656e-07 2.22279412449515 0.0516111370736547 MirTarget;miRNATAP -0.236984996685837 0.00244589289765692 NA NA NA hsa-miR-182-5p CD274 5.86988712704738 1.22411588571584e-15 2.22279412449515 0.0516111370736547 mirMAP -0.339706442437269 4.80944840181619e-05 NA NA NA hsa-miR-200a-3p CD274 6.336081120041 4.024313571871e-16 2.22279412449515 0.0516111370736547 MirTarget -0.349325798251526 8.24128678574652e-06 NA NA NA hsa-miR-20b-5p CD274 4.5662923200279 4.75238200639144e-05 2.22279412449515 0.0516111370736547 MirTarget;miRNATAP -0.192258791595886 0.000703899942107355 24468585 These findings suggest that miR-20b -21 and -130b up-regulated in colorectal cancer through inhibiting the expression of PTEN result in B7-H1 over-expression in colorectal cancer colorectal cancer hsa-miR-324-5p CD274 1.31253452379847 0.0116806680545163 2.22279412449515 0.0516111370736547 miRanda -0.47313482826795 0.000139757569599412 NA NA NA hsa-miR-429 CD274 6.39965293994036 1.96920201593608e-18 2.22279412449515 0.0516111370736547 miRanda -0.414756964042163 4.97744617535068e-07 NA NA NA hsa-miR-497-5p CD274 -1.44150596209372 0.0225146607606395 2.22279412449515 0.0516111370736547 MirTarget -0.383087599725002 0.000175050271995498 NA NA NA hsa-miR-93-5p CD274 2.65964181833033 2.58315947526774e-08 2.22279412449515 0.0516111370736547 MirTarget;miRNATAP -0.455113489627987 0.000638032417442551 NA NA NA hsa-miR-582-5p CHP2 0.685177900016753 0.447761540297692 1.48109800587141 0.509563690322669 miRNATAP -0.415938249783453 0.0031281915626761 NA NA NA hsa-miR-21-3p CREBBP 3.50297439576639 6.39946844099206e-10 -0.3958302023172 0.180670093990074 MirTarget -0.1378273582574 1.08112070034993e-06 NA NA NA hsa-miR-590-3p CREBBP 2.35429565068338 2.79601879608564e-06 -0.3958302023172 0.180670093990074 PITA;miRanda;mirMAP;miRNATAP -0.100352894791816 0.00219317602458258 NA NA NA hsa-miR-186-5p CSNK1A1 0.445443449112564 0.185447310527704 0.245408374500098 0.395572169059955 miRNAWalker2_validate;miRNATAP -0.193913704202309 7.79674302869086e-05 NA NA NA hsa-miR-30a-5p CSNK1A1 -0.768430903969183 0.320487552854215 0.245408374500098 0.395572169059955 MirTarget;miRNATAP -0.135041314174073 3.59236678762335e-11 NA NA NA hsa-miR-7-1-3p CSNK1A1 1.43074343339835 0.00471215970502094 0.245408374500098 0.395572169059955 mirMAP -0.120672027161425 0.000159669158986854 NA NA NA hsa-miR-125a-5p CSNK2A1 -1.32352790615388 0.00714301627309467 0.48381180381159 0.0913360923034785 MirTarget;PITA;miRanda -0.108571262854327 0.000935806228856506 NA NA NA hsa-miR-26a-5p CSNK2A1 -0.352368463397074 0.362040749917446 0.48381180381159 0.0913360923034785 mirMAP -0.108934105670422 0.0103356523493601 NA NA NA hsa-miR-374a-5p CSNK2A2 0.278549982012055 0.45888283715888 -0.634457620730887 0.030975154236773 mirMAP -0.103116999156007 0.0219854619997714 NA NA NA hsa-miR-342-3p CTBP2 1.31107714473009 0.0207211910724662 -0.534858240246571 0.121949363819826 MirTarget;PITA;miRanda;miRNATAP -0.126298130193261 0.000232764023108101 NA NA NA hsa-let-7a-3p CTNNB1 0.82512001802525 0.0468122405194487 -0.598740867811971 0.152216124887482 MirTarget;miRNATAP -0.125908170191691 0.029188853953634 NA NA NA hsa-let-7b-3p CTNNB1 0.589364128513318 0.200507534602851 -0.598740867811971 0.152216124887482 MirTarget;miRNATAP -0.103030934176016 0.0475290406533916 NA NA NA hsa-let-7f-1-3p CTNNB1 1.61507869803314 0.00069342464777815 -0.598740867811971 0.152216124887482 MirTarget -0.125968469814992 0.0117067486394951 NA NA NA hsa-miR-150-5p CTNNB1 1.76769157530064 0.0593795975117846 -0.598740867811971 0.152216124887482 MirTarget -0.1161821301588 2.89988026655084e-06 NA NA NA hsa-miR-155-5p CTNNB1 2.81443182173772 7.42530504828797e-05 -0.598740867811971 0.152216124887482 miRNAWalker2_validate -0.166081896357714 3.05605612118335e-07 NA NA NA hsa-miR-221-3p CTNNB1 0.94082283577318 0.174749164179978 -0.598740867811971 0.152216124887482 miRNAWalker2_validate -0.15386110666748 5.20471332163171e-06 NA NA NA hsa-miR-330-3p CTNNB1 2.49094236945806 0.000129367003214715 -0.598740867811971 0.152216124887482 MirTarget;PITA;miRNATAP -0.113866447624475 0.00159137187547744 NA NA NA hsa-miR-590-3p CTNNB1 2.35429565068338 2.79601879608564e-06 -0.598740867811971 0.152216124887482 miRanda -0.159536768797246 0.00059253265161602 NA NA NA hsa-miR-10a-5p CTNNBIP1 -0.482300926520507 0.594608783320466 1.03005539288975 0.0177273867076639 miRNATAP -0.126697371710711 2.36218282426033e-06 NA NA NA hsa-miR-125a-3p CTNNBIP1 -0.0748960586927341 0.920735897434087 1.03005539288975 0.0177273867076639 miRanda -0.170413612828531 1.31498706666802e-07 NA NA NA hsa-miR-125a-5p CTNNBIP1 -1.32352790615388 0.00714301627309467 1.03005539288975 0.0177273867076639 mirMAP -0.187649059978902 0.00017266028748789 NA NA NA hsa-miR-192-5p CTNNBIP1 1.77716187978541 0.113485496183047 1.03005539288975 0.0177273867076639 miRNAWalker2_validate;MirTarget;miRNATAP -0.132175883814956 5.67049965084063e-10 NA NA NA hsa-miR-215-5p CTNNBIP1 3.66990923176752 0.00294614570694381 1.03005539288975 0.0177273867076639 miRNAWalker2_validate;MirTarget -0.100891368557812 2.29881480994223e-07 NA NA NA hsa-miR-28-5p CTNNBIP1 -0.815636722979196 0.0221199948901761 1.03005539288975 0.0177273867076639 MirTarget;miRanda -0.169310313364841 0.0161675148648094 NA NA NA hsa-miR-32-5p CTNNBIP1 2.93035124381469 5.00149131394151e-10 1.03005539288975 0.0177273867076639 miRNATAP -0.102914108723477 0.0449674434685021 NA NA NA hsa-miR-335-5p CTNNBIP1 0.167216045757305 0.803897055331049 1.03005539288975 0.0177273867076639 miRNAWalker2_validate;mirMAP -0.15744834958761 1.48207299376159e-05 NA NA NA hsa-miR-505-5p CTNNBIP1 -0.548246528900629 0.331409094367131 1.03005539288975 0.0177273867076639 MirTarget -0.12792172445794 0.00351604379386236 NA NA NA hsa-miR-625-5p CTNNBIP1 2.02792641909347 0.000935142379948297 1.03005539288975 0.0177273867076639 mirMAP -0.120181043685081 0.00286205398441888 NA NA NA hsa-miR-92b-3p CTNNBIP1 1.69303761469782 0.0103484911955574 1.03005539288975 0.0177273867076639 miRNATAP -0.200586456269185 4.0720456477811e-08 NA NA NA hsa-let-7g-3p DAAM1 2.09736290930341 5.30067796437833e-05 0.276570533956138 0.675263432310241 MirTarget -0.297254323759927 2.83072967462045e-05 NA NA NA hsa-miR-125a-5p DAAM1 -1.32352790615388 0.00714301627309467 0.276570533956138 0.675263432310241 MirTarget -0.275633109591266 0.000276738430676473 NA NA NA hsa-miR-142-3p DAAM1 4.35304505457969 3.10014573651358e-10 0.276570533956138 0.675263432310241 miRanda -0.110694753038476 0.035250792077707 NA NA NA hsa-miR-181c-5p DAAM1 -0.302833440762172 0.537532549455539 0.276570533956138 0.675263432310241 mirMAP -0.259662296598169 0.000684412511064248 NA NA NA hsa-miR-186-5p DAAM1 0.445443449112564 0.185447310527704 0.276570533956138 0.675263432310241 MirTarget;mirMAP -0.542676564610488 1.31439489133088e-06 NA NA NA hsa-miR-194-5p DAAM1 0.691219038144468 0.523143086635506 0.276570533956138 0.675263432310241 miRNATAP -0.171266373999645 4.52372161332232e-07 NA NA NA hsa-miR-19b-3p DAAM1 1.67581705793313 0.000858910586302716 0.276570533956138 0.675263432310241 miRNATAP -0.18546021303289 0.0125833456062853 NA NA NA hsa-miR-218-5p DAAM1 -1.62589026509455 0.0400573414088521 0.276570533956138 0.675263432310241 MirTarget;miRNATAP -0.108271978358032 0.0216116861894506 NA NA NA hsa-miR-29b-3p DAAM1 0.666547117072858 0.234055379278093 0.276570533956138 0.675263432310241 MirTarget;miRNATAP -0.192846740572908 0.00397875371633019 NA NA NA hsa-miR-29c-3p DAAM1 -0.414153610337085 0.529344128062017 0.276570533956138 0.675263432310241 MirTarget;miRNATAP -0.158827295076248 0.00523060177652306 NA NA NA hsa-miR-301a-3p DAAM1 1.99338115332667 0.000813358604963724 0.276570533956138 0.675263432310241 MirTarget;miRNATAP -0.12283680768909 0.0499383668124343 NA NA NA hsa-miR-32-3p DAAM1 2.20477794939766 0.0392771274032852 0.276570533956138 0.675263432310241 mirMAP -0.132027263877499 0.0323222450904459 NA NA NA hsa-miR-32-5p DAAM1 2.93035124381469 5.00149131394151e-10 0.276570533956138 0.675263432310241 miRNATAP -0.218491380893966 0.004856799210676 NA NA NA hsa-miR-335-5p DAAM1 0.167216045757305 0.803897055331049 0.276570533956138 0.675263432310241 miRNAWalker2_validate;MirTarget;miRNATAP -0.190183727710072 0.000600904552801714 NA NA NA hsa-miR-34a-5p DAAM1 0.830377770217786 0.0477544831885907 0.276570533956138 0.675263432310241 MirTarget;miRNATAP -0.325853056210634 0.000276123613355551 NA NA NA hsa-miR-362-3p DAAM1 0.679952485897744 0.226148468488576 0.276570533956138 0.675263432310241 MirTarget;miRanda;miRNATAP -0.214862898719501 0.00131317919934595 NA NA NA hsa-miR-454-3p DAAM1 1.40269869979902 0.00366085847011367 0.276570533956138 0.675263432310241 MirTarget;miRNATAP -0.241034433328455 0.00185755336403306 NA NA NA hsa-miR-590-3p DAAM1 2.35429565068338 2.79601879608564e-06 0.276570533956138 0.675263432310241 MirTarget;miRanda;mirMAP -0.2443961632374 0.000873002406433808 NA NA NA hsa-miR-92b-3p DAAM1 1.69303761469782 0.0103484911955574 0.276570533956138 0.675263432310241 miRNATAP -0.177936379756159 0.00158344292711636 NA NA NA hsa-miR-96-5p DAAM1 5.62521466029286 1.54938806718028e-10 0.276570533956138 0.675263432310241 TargetScan;miRNATAP -0.126252808851385 0.012445099480256 NA NA NA hsa-miR-141-5p DAAM2 7.13744624551943 4.06877058732583e-26 -4.26053553183336 8.29673298827332e-06 mirMAP -0.570696163982686 1.46055145639665e-15 NA NA NA hsa-miR-182-5p DAAM2 5.86988712704738 1.22411588571584e-15 -4.26053553183336 8.29673298827332e-06 mirMAP -0.207255779338193 0.00365677570338477 NA NA NA hsa-miR-18a-5p DAAM2 3.90770175770219 9.15298615034137e-10 -4.26053553183336 8.29673298827332e-06 miRNAWalker2_validate -0.307828697056098 0.000227514437839013 NA NA NA hsa-miR-193a-3p DAAM2 0.646392169474854 0.207134343676122 -4.26053553183336 8.29673298827332e-06 miRanda -0.49295339375629 3.95496864969965e-06 NA NA NA hsa-miR-1976 DAAM2 3.27217274919653 3.16337235854532e-12 -4.26053553183336 8.29673298827332e-06 mirMAP -0.552551233273318 8.55297658334893e-07 NA NA NA hsa-miR-19b-3p DAAM2 1.67581705793313 0.000858910586302716 -4.26053553183336 8.29673298827332e-06 miRNAWalker2_validate -0.23088466901671 0.03512143579139 NA NA NA hsa-miR-205-5p DAAM2 8.08298115900323 3.83045179398654e-07 -4.26053553183336 8.29673298827332e-06 mirMAP -0.188663285143127 1.15811050103557e-08 NA NA NA hsa-miR-339-5p DAAM2 1.23326828594484 0.0307501214818698 -4.26053553183336 8.29673298827332e-06 miRanda -0.404277523636253 2.39445351225706e-05 NA NA NA hsa-miR-361-3p DAAM2 0.805698609170807 0.0418491665498322 -4.26053553183336 8.29673298827332e-06 mirMAP -0.672224247551321 1.30348412242707e-06 NA NA NA hsa-miR-421 DAAM2 1.97624148591545 0.000915838012451138 -4.26053553183336 8.29673298827332e-06 PITA;miRanda -0.21230717913501 0.0214861897197032 NA NA NA hsa-miR-429 DAAM2 6.39965293994036 1.96920201593608e-18 -4.26053553183336 8.29673298827332e-06 miRNATAP -0.231093435020544 0.00109269266179537 NA NA NA hsa-miR-590-3p DAAM2 2.35429565068338 2.79601879608564e-06 -4.26053553183336 8.29673298827332e-06 miRanda;mirMAP -0.584835747939958 3.92624647177008e-08 NA NA NA hsa-miR-193a-3p DKK2 0.646392169474854 0.207134343676122 -1.67695241592961 0.165352633703973 miRanda -0.657128532340711 7.59835105511743e-07 NA NA NA hsa-miR-221-3p DKK2 0.94082283577318 0.174749164179978 -1.67695241592961 0.165352633703973 miRNAWalker2_validate;miRTarBase -0.274741130773507 0.00550784821701667 NA NA NA hsa-miR-27a-3p DKK2 1.76094007417453 0.000216137556256765 -1.67695241592961 0.165352633703973 miRNATAP -0.673957157945868 2.11730971088654e-06 NA NA NA hsa-miR-324-5p DKK2 1.31253452379847 0.0116806680545163 -1.67695241592961 0.165352633703973 miRanda -0.306611131683688 0.0204523123000633 NA NA NA hsa-miR-33a-3p DKK2 2.06269680799532 0.00156436055383943 -1.67695241592961 0.165352633703973 mirMAP -0.28395098081343 0.00692346131639689 NA NA NA hsa-miR-486-5p DKK2 1.10898145177457 0.309287974401609 -1.67695241592961 0.165352633703973 miRanda;miRNATAP -0.187952045051441 0.00269369273726781 NA NA NA hsa-miR-590-3p DKK2 2.35429565068338 2.79601879608564e-06 -1.67695241592961 0.165352633703973 miRanda;mirMAP;miRNATAP -0.275565936517306 0.0420503365559476 NA NA NA hsa-miR-590-5p DKK2 1.51400888103768 0.0023888567923017 -1.67695241592961 0.165352633703973 miRanda -0.434105282780938 0.00158369991842918 NA NA NA hsa-miR-944 DKK2 7.20925181386398 0.000823207457340648 -1.67695241592961 0.165352633703973 mirMAP -0.147923599569798 0.000146766558529192 NA NA NA hsa-miR-335-5p DKK4 0.167216045757305 0.803897055331049 1.37274467499535 0.386108555859798 miRNAWalker2_validate -0.622243538154658 2.47277624073016e-06 NA NA NA hsa-miR-10a-5p DVL1 -0.482300926520507 0.594608783320466 0.0930830936484925 0.802605048970877 miRNAWalker2_validate -0.11026504710669 1.40870159993299e-06 NA NA NA hsa-miR-125a-5p DVL3 -1.32352790615388 0.00714301627309467 0.712696667163076 0.0441831929271895 PITA -0.114291084779072 0.00510375398533769 NA NA NA hsa-miR-146b-3p DVL3 1.34608871980101 0.00935728391852709 0.712696667163076 0.0441831929271895 MirTarget -0.152558917031062 7.36274039601236e-05 NA NA NA hsa-miR-29b-2-5p DVL3 -0.596051745078872 0.189540844841389 0.712696667163076 0.0441831929271895 MirTarget -0.119308522306106 0.00736926175410278 NA NA NA hsa-miR-30a-3p DVL3 -1.22212086897848 0.167565797592104 0.712696667163076 0.0441831929271895 MirTarget -0.122406816743673 3.30206813290696e-08 NA NA NA hsa-miR-30d-3p DVL3 -0.0740421896025512 0.857423650167556 0.712696667163076 0.0441831929271895 MirTarget -0.106047345372871 0.0318918957944879 NA NA NA hsa-miR-320a DVL3 -0.912036444869976 0.0565555443926988 0.712696667163076 0.0441831929271895 miRNAWalker2_validate;miRanda -0.104640238798596 0.0131382381274219 NA NA NA hsa-miR-148a-3p EP300 1.1031350648218 0.052038169812979 0.224331914964019 0.578934208058052 miRNATAP -0.104185690998739 0.00975228544208279 NA NA NA hsa-miR-26b-5p EP300 0.314414148564179 0.461628303578321 0.224331914964019 0.578934208058052 miRNAWalker2_validate;miRNATAP -0.133193686886669 0.0139568858207426 NA NA NA hsa-miR-30c-5p EP300 0.38723991118075 0.348605235643473 0.224331914964019 0.578934208058052 miRNAWalker2_validate -0.18542784496307 0.000897194160521004 NA NA NA hsa-miR-339-5p EP300 1.23326828594484 0.0307501214818698 0.224331914964019 0.578934208058052 miRanda -0.199156483102611 4.47682764951844e-07 NA NA NA hsa-miR-342-3p EP300 1.31107714473009 0.0207211910724662 0.224331914964019 0.578934208058052 MirTarget;PITA;miRanda;miRNATAP -0.115722711407846 0.00406603413994019 NA NA NA hsa-miR-361-3p EP300 0.805698609170807 0.0418491665498322 0.224331914964019 0.578934208058052 PITA -0.135942435196129 0.0200803551179427 NA NA NA hsa-miR-374b-5p EP300 -0.114749866169918 0.764888930049438 0.224331914964019 0.578934208058052 mirMAP;miRNATAP -0.159199926258203 0.00855691297646884 NA NA NA hsa-miR-590-3p EP300 2.35429565068338 2.79601879608564e-06 0.224331914964019 0.578934208058052 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.136964991854083 0.00229030845745203 NA NA NA hsa-miR-148b-3p FBXW11 1.75622244535669 8.84414356040579e-08 -0.558881503264246 0.0547787087394548 miRNAWalker2_validate -0.137834010500419 0.00589089218467001 NA NA NA hsa-miR-331-3p FBXW11 2.60769294751513 3.84318952029483e-07 -0.558881503264246 0.0547787087394548 miRNATAP -0.103415497025069 0.00100190758728944 NA NA NA hsa-miR-374b-5p FBXW11 -0.114749866169918 0.764888930049438 -0.558881503264246 0.0547787087394548 mirMAP -0.131824038103188 0.00241540705330138 NA NA NA hsa-miR-590-3p FBXW11 2.35429565068338 2.79601879608564e-06 -0.558881503264246 0.0547787087394548 mirMAP -0.101190816629317 0.00171731927469691 NA NA NA hsa-miR-301a-3p FOSL1 1.99338115332667 0.000813358604963724 2.10358791044215 0.0497968487699577 MirTarget -0.215716873378991 0.0346627625217642 NA NA NA hsa-miR-34a-5p FOSL1 0.830377770217786 0.0477544831885907 2.10358791044215 0.0497968487699577 miRNAWalker2_validate;miRTarBase -0.395916583554062 0.00700648816785535 22198213;23001043 MicroRNA 34a inhibits migration and invasion of colon cancer cells via targeting to Fra 1; Here we identified Fra-1 as a new target of miR-34a and demonstrated that miR-34a inhibits Fra-1 expression at both protein and messenger RNA levels; Overexpression of miR-34a strongly inhibited colon cancer cell migration and invasion which can be partially rescued by forced expression of the Fra-1 transcript lacking the 3'-untranslated region;Moreover significant downregulation of miR-34a in metastatic breast cancer tissues was found to be inversely correlated with Fra-1 expression; Our results demonstrate that miR-34a/c functions as a metastasis suppressor to regulate breast cancer migration and invasion through targeting Fra-1 oncogene and suggest a therapeutic application of miR-34 in breast cancer cell migration;metastasis colon cancer;breast cancer hsa-miR-454-3p FOSL1 1.40269869979902 0.00366085847011367 2.10358791044215 0.0497968487699577 MirTarget -0.339122687493332 0.00737228376919168 NA NA NA hsa-miR-130a-5p FRAT1 1.58028512890005 0.024346333013728 -0.419842156082442 0.342841896838572 miRNATAP -0.100178156665785 0.00567186145941396 NA NA NA hsa-miR-22-3p FRAT2 0.845430028554782 0.0148923883819448 1.3647650151325 0.000947277064166433 miRNAWalker2_validate;MirTarget;miRNATAP -0.265227851027296 0.000107912254541356 NA NA NA hsa-miR-146b-5p FZD1 1.87569569182453 0.000737241069698886 -0.318491374654607 0.491789959368398 MirTarget;PITA;miRanda -0.12122238704442 0.00988542294343242 NA NA NA hsa-miR-148b-5p FZD1 2.80812018666078 3.97536665756679e-08 -0.318491374654607 0.491789959368398 MirTarget -0.130005236923503 0.0100004560293311 NA NA NA hsa-miR-29a-3p FZD1 -0.638239697975974 0.251923581881716 -0.318491374654607 0.491789959368398 mirMAP -0.171333710769929 0.00026723836872456 NA NA NA hsa-miR-29b-3p FZD1 0.666547117072858 0.234055379278093 -0.318491374654607 0.491789959368398 mirMAP -0.223781902211902 1.38655813660173e-06 NA NA NA hsa-miR-29c-3p FZD1 -0.414153610337085 0.529344128062017 -0.318491374654607 0.491789959368398 mirMAP -0.10077019791282 0.0115598590608908 NA NA NA hsa-miR-590-3p FZD1 2.35429565068338 2.79601879608564e-06 -0.318491374654607 0.491789959368398 miRanda -0.178450935504682 0.000518778693117224 NA NA NA hsa-miR-25-3p FZD10 1.12623030168869 0.00311079344417173 0.817127632737711 0.546902427216764 miRNATAP -0.420785771168102 0.0396094818640195 NA NA NA hsa-miR-335-5p FZD10 0.167216045757305 0.803897055331049 0.817127632737711 0.546902427216764 miRNAWalker2_validate -0.32447150664636 0.0045590174989641 NA NA NA hsa-miR-92b-3p FZD10 1.69303761469782 0.0103484911955574 0.817127632737711 0.546902427216764 miRNATAP -0.408813919349178 0.000408188212271156 NA NA NA hsa-let-7b-3p FZD3 0.589364128513318 0.200507534602851 -2.2712968833062 0.0197819973302092 MirTarget;miRNATAP -0.391775229422405 0.00123397253469845 NA NA NA hsa-let-7b-5p FZD3 -0.189422992330471 0.651878220048983 -2.2712968833062 0.0197819973302092 MirTarget;miRNATAP -0.400834438580578 0.00271706179103384 NA NA NA hsa-let-7c-5p FZD3 -2.03831836681378 0.0228401148731997 -2.2712968833062 0.0197819973302092 MirTarget -0.154316063333049 0.0123550688392452 NA NA NA hsa-let-7f-1-3p FZD3 1.61507869803314 0.00069342464777815 -2.2712968833062 0.0197819973302092 MirTarget -0.31298120278851 0.00751255516333369 NA NA NA hsa-miR-125b-2-3p FZD3 -1.75609980210443 0.122616157214143 -2.2712968833062 0.0197819973302092 mirMAP -0.10582619005298 0.0299082887680915 NA NA NA hsa-miR-140-5p FZD3 -0.634610285725923 0.126670572966239 -2.2712968833062 0.0197819973302092 miRanda -0.272202484463936 0.0444914920459578 NA NA NA hsa-miR-142-3p FZD3 4.35304505457969 3.10014573651358e-10 -2.2712968833062 0.0197819973302092 miRanda -0.335676063800471 1.33860192234743e-05 NA NA NA hsa-miR-146a-5p FZD3 2.64646698525354 0.000280611928973036 -2.2712968833062 0.0197819973302092 MirTarget -0.373068677777254 5.20415294434459e-07 NA NA NA hsa-miR-155-5p FZD3 2.81443182173772 7.42530504828797e-05 -2.2712968833062 0.0197819973302092 mirMAP -0.359934463087244 2.38470974855901e-06 NA NA NA hsa-miR-16-1-3p FZD3 2.83281226969693 7.54359864580834e-09 -2.2712968833062 0.0197819973302092 mirMAP -0.319820172643704 0.00394897878069372 NA NA NA hsa-miR-16-2-3p FZD3 3.79845098071094 1.49120139344659e-13 -2.2712968833062 0.0197819973302092 mirMAP -0.313624624836376 0.00252529278231522 NA NA NA hsa-miR-195-3p FZD3 -2.39100534119332 0.000185405399054065 -2.2712968833062 0.0197819973302092 mirMAP -0.192884555590929 0.0261403716126617 NA NA NA hsa-miR-205-5p FZD3 8.08298115900323 3.83045179398654e-07 -2.2712968833062 0.0197819973302092 MirTarget -0.168834170318472 4.72789797910524e-07 25521201 Our data analysis also showed that miR-98 and miR-205 have two common predicted target genes FZD3 and RPS6KA3 which are actually genes associated with carcinoma according to the Online Mendelian Inheritance in Man OMIM database lung squamous cell cancer hsa-miR-23b-3p FZD3 -0.581135273821923 0.190478897170459 -2.2712968833062 0.0197819973302092 MirTarget -0.421924654848594 0.000798515248907007 NA NA NA hsa-miR-27a-3p FZD3 1.76094007417453 0.000216137556256765 -2.2712968833062 0.0197819973302092 miRNATAP -0.256205017282443 0.0279246751622382 NA NA NA hsa-miR-27b-3p FZD3 -0.0929089601968123 0.85847352206581 -2.2712968833062 0.0197819973302092 miRNATAP -0.372976594023668 0.000477589576040137 NA NA NA hsa-miR-30e-5p FZD3 0.780047227271616 0.0346714425913016 -2.2712968833062 0.0197819973302092 MirTarget -0.387879206065752 0.0110297198191719 NA NA NA hsa-miR-31-5p FZD3 7.15600983164746 6.64190917357724e-10 -2.2712968833062 0.0197819973302092 miRNAWalker2_validate;MirTarget;miRNATAP -0.118963678262536 0.0102566928791995 NA NA NA hsa-miR-342-3p FZD3 1.31107714473009 0.0207211910724662 -2.2712968833062 0.0197819973302092 miRanda -0.295682048421979 0.00249712798748224 NA NA NA hsa-miR-34c-3p FZD3 4.0411891981675 0.000195495966405666 -2.2712968833062 0.0197819973302092 mirMAP -0.107742106407298 0.0342585327995053 NA NA NA hsa-miR-34c-5p FZD3 2.64675661251039 0.0157394735757952 -2.2712968833062 0.0197819973302092 miRanda -0.106633503506605 0.0345850782250064 NA NA NA hsa-miR-452-3p FZD3 2.97956996345436 0.000203580834647624 -2.2712968833062 0.0197819973302092 MirTarget -0.222632262971689 0.00114068931063861 NA NA NA hsa-miR-452-5p FZD3 2.45466810475361 0.00114794259949532 -2.2712968833062 0.0197819973302092 mirMAP -0.327172010172874 5.73268775022015e-06 NA NA NA hsa-miR-944 FZD3 7.20925181386398 0.000823207457340648 -2.2712968833062 0.0197819973302092 MirTarget;PITA;miRNATAP -0.201675798691389 5.69788087904236e-11 NA NA NA hsa-let-7a-3p FZD4 0.82512001802525 0.0468122405194487 -2.83886953461754 3.72732903465121e-05 mirMAP -0.289191281655542 0.00261784404358226 NA NA NA hsa-let-7b-3p FZD4 0.589364128513318 0.200507534602851 -2.83886953461754 3.72732903465121e-05 mirMAP -0.229269440598043 0.00813497276382615 NA NA NA hsa-let-7b-5p FZD4 -0.189422992330471 0.651878220048983 -2.83886953461754 3.72732903465121e-05 MirTarget;miRNATAP -0.275360310596682 0.00386154408558111 NA NA NA hsa-let-7f-1-3p FZD4 1.61507869803314 0.00069342464777815 -2.83886953461754 3.72732903465121e-05 mirMAP -0.271909202878902 0.00107897881690323 NA NA NA hsa-miR-141-3p FZD4 7.30474126597325 1.45115996357606e-24 -2.83886953461754 3.72732903465121e-05 TargetScan -0.146207262935211 0.00415064235917507 NA NA NA hsa-miR-150-5p FZD4 1.76769157530064 0.0593795975117846 -2.83886953461754 3.72732903465121e-05 miRNATAP -0.131035747829938 0.00176171330583994 NA NA NA hsa-miR-15b-5p FZD4 3.32329949959268 8.40210501034588e-13 -2.83886953461754 3.72732903465121e-05 MirTarget -0.282999459031275 0.000569874909623984 NA NA NA hsa-miR-16-5p FZD4 2.93575808220754 2.15436817162977e-10 -2.83886953461754 3.72732903465121e-05 MirTarget -0.227505888117745 0.00647410235924482 NA NA NA hsa-miR-200b-3p FZD4 5.56167217794639 6.43540045061709e-16 -2.83886953461754 3.72732903465121e-05 mirMAP -0.238298937559481 1.05112124811421e-05 NA NA NA hsa-miR-200c-3p FZD4 6.47012025883743 2.64500707716408e-26 -2.83886953461754 3.72732903465121e-05 mirMAP -0.233220034337669 8.01322431715165e-05 NA NA NA hsa-miR-224-3p FZD4 2.84876340814503 0.000179138399939161 -2.83886953461754 3.72732903465121e-05 MirTarget -0.28225814299032 2.87859841920122e-08 NA NA NA hsa-miR-24-3p FZD4 1.55853749533999 0.000524726461381821 -2.83886953461754 3.72732903465121e-05 miRNAWalker2_validate -0.189566808452121 0.0316727557921928 NA NA NA hsa-miR-25-3p FZD4 1.12623030168869 0.00311079344417173 -2.83886953461754 3.72732903465121e-05 mirMAP -0.316761893783551 0.00247147999129914 NA NA NA hsa-miR-27a-3p FZD4 1.76094007417453 0.000216137556256765 -2.83886953461754 3.72732903465121e-05 miRNATAP -0.261515033149759 0.00156287118774928 NA NA NA hsa-miR-27b-3p FZD4 -0.0929089601968123 0.85847352206581 -2.83886953461754 3.72732903465121e-05 miRNATAP -0.243490119104825 0.0013959995389089 NA NA NA hsa-miR-33a-3p FZD4 2.06269680799532 0.00156436055383943 -2.83886953461754 3.72732903465121e-05 mirMAP -0.315492579937533 1.17062941143373e-07 NA NA NA hsa-miR-429 FZD4 6.39965293994036 1.96920201593608e-18 -2.83886953461754 3.72732903465121e-05 mirMAP -0.223467585312549 9.44591820899412e-06 NA NA NA hsa-miR-452-5p FZD4 2.45466810475361 0.00114794259949532 -2.83886953461754 3.72732903465121e-05 miRNATAP -0.314911211799412 5.04643655024212e-10 NA NA NA hsa-miR-576-5p FZD4 1.30320223793746 0.00648929463912994 -2.83886953461754 3.72732903465121e-05 mirMAP -0.216830219353013 0.00885127918136263 NA NA NA hsa-miR-590-3p FZD4 2.35429565068338 2.79601879608564e-06 -2.83886953461754 3.72732903465121e-05 miRanda;mirMAP;miRNATAP -0.229697889158717 0.00314265095609673 NA NA NA hsa-miR-629-3p FZD4 3.48282157979573 4.9176538695908e-08 -2.83886953461754 3.72732903465121e-05 miRNATAP -0.227018116324061 0.00016531596497597 NA NA NA hsa-miR-653-5p FZD4 1.43354001460259 0.0479177174923075 -2.83886953461754 3.72732903465121e-05 MirTarget -0.16470578851558 0.0027849753448391 NA NA NA hsa-miR-708-5p FZD4 1.70409736218557 0.0319538709865338 -2.83886953461754 3.72732903465121e-05 miRNATAP -0.193141187540541 8.78652560864314e-05 NA NA NA hsa-let-7b-3p FZD5 0.589364128513318 0.200507534602851 0.640287282353737 0.297444783437361 miRNATAP -0.205895528602781 0.00696500873050967 NA NA NA hsa-miR-142-5p FZD5 3.95552531913424 1.49536283724079e-08 0.640287282353737 0.297444783437361 mirMAP -0.104934380484508 0.0313736986798336 NA NA NA hsa-miR-155-5p FZD5 2.81443182173772 7.42530504828797e-05 0.640287282353737 0.297444783437361 miRNATAP -0.211896725721244 1.00818321655591e-05 NA NA NA hsa-miR-23a-3p FZD5 0.925125296618358 0.0127293543936914 0.640287282353737 0.297444783437361 miRNATAP -0.289711657168532 0.00225871469675491 NA NA NA hsa-miR-23b-3p FZD5 -0.581135273821923 0.190478897170459 0.640287282353737 0.297444783437361 miRNATAP -0.280347016349859 0.000379321134775307 NA NA NA hsa-miR-24-3p FZD5 1.55853749533999 0.000524726461381821 0.640287282353737 0.297444783437361 miRNAWalker2_validate;miRNATAP -0.22875330448975 0.00314726074883253 NA NA NA hsa-miR-342-3p FZD5 1.31107714473009 0.0207211910724662 0.640287282353737 0.297444783437361 PITA -0.186426276738242 0.0023834988286169 NA NA NA hsa-miR-99a-5p FZD5 -2.72139054000803 0.00621971944534118 0.640287282353737 0.297444783437361 MirTarget;miRNATAP -0.125875532977723 0.000270995390359697 NA NA NA hsa-miR-194-5p FZD6 0.691219038144468 0.523143086635506 1.58130849246817 0.00919065409091848 MirTarget -0.251019560286905 1.22839454916662e-16 NA NA NA hsa-miR-454-3p FZD6 1.40269869979902 0.00366085847011367 1.58130849246817 0.00919065409091848 MirTarget -0.146948221725738 0.0409812526187463 NA NA NA hsa-miR-142-3p FZD7 4.35304505457969 3.10014573651358e-10 -2.72325006685666 0.00150687292014913 miRanda -0.373560938656454 3.11438751908879e-08 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7; In addition we demonstrated that FZD7 was a direct target of miR-142-3p by dual luciferase assay and Western blot analysis; Overexpression of FZD7 expression was able to reverse the inhibitory effects induced by miR-142-3p cervical and endocervical cancer hsa-miR-142-5p FZD7 3.95552531913424 1.49536283724079e-08 -2.72325006685666 0.00150687292014913 MirTarget;PITA;miRNATAP -0.362955447075897 6.92115542119614e-08 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7 cervical and endocervical cancer hsa-miR-192-5p FZD7 1.77716187978541 0.113485496183047 -2.72325006685666 0.00150687292014913 miRNAWalker2_validate -0.115148199976731 0.00808053119326572 NA NA NA hsa-miR-215-5p FZD7 3.66990923176752 0.00294614570694381 -2.72325006685666 0.00150687292014913 miRNAWalker2_validate -0.128832283203823 0.00103711067552621 NA NA NA hsa-miR-27a-3p FZD7 1.76094007417453 0.000216137556256765 -2.72325006685666 0.00150687292014913 MirTarget;miRNATAP -0.217090317137875 0.0350875608966041 24018051 Moreover up-regulation of miR-27a did not decrease the FZD7 mRNA level but significantly reduce its protein expression in BEL/5-FU cells; It was also confirmed that reduction of FZD7 by RNA interference induced inhibitory effects on the expression of MDR1/P-glycoprotein and β-catenin similar to miR-27a liver cancer hsa-miR-330-3p FZD7 2.49094236945806 0.000129367003214715 -2.72325006685666 0.00150687292014913 mirMAP -0.278992643858465 0.000179188356936391 NA NA NA hsa-miR-338-3p FZD7 0.447551118940466 0.558485097370031 -2.72325006685666 0.00150687292014913 miRanda -0.147180053920719 0.0218884792744351 NA NA NA hsa-miR-338-5p FZD7 -0.108304629897487 0.894675560494607 -2.72325006685666 0.00150687292014913 MirTarget;PITA;miRNATAP -0.165566070058614 0.00594825069199063 NA NA NA hsa-miR-590-3p FZD7 2.35429565068338 2.79601879608564e-06 -2.72325006685666 0.00150687292014913 miRanda -0.403041157541026 2.56570813299877e-05 NA NA NA hsa-miR-590-3p FZD8 2.35429565068338 2.79601879608564e-06 -0.605760786756907 0.557609369330486 miRanda -0.346881927689195 0.00260365350935014 NA NA NA hsa-miR-192-5p FZD9 1.77716187978541 0.113485496183047 0.892340449420943 0.433615785945545 miRNATAP -0.269388155649398 1.93576138120715e-06 NA NA NA hsa-miR-181c-5p GSK3B -0.302833440762172 0.537532549455539 0.984264794042029 0.00614784819440891 mirMAP -0.115369483842179 0.00582165998524454 NA NA NA hsa-miR-30a-3p GSK3B -1.22212086897848 0.167565797592104 0.984264794042029 0.00614784819440891 miRNATAP -0.11517576765646 3.57050461951731e-07 NA NA NA hsa-miR-30d-3p GSK3B -0.0740421896025512 0.857423650167556 0.984264794042029 0.00614784819440891 miRNATAP -0.217356687168476 1.21966436788369e-05 NA NA NA hsa-miR-320c GSK3B -0.10618808730545 0.854002814666472 0.984264794042029 0.00614784819440891 miRanda;mirMAP -0.100605875350465 0.00537879672016752 NA NA NA hsa-miR-362-5p GSK3B -1.22309034685697 0.0452665543907975 0.984264794042029 0.00614784819440891 miRNATAP -0.116235509089146 0.000473661337943669 NA NA NA hsa-miR-141-3p JUN 7.30474126597325 1.45115996357606e-24 -1.39678224976456 0.0210065056705043 miRNATAP -0.140631808287642 0.00151406596577943 NA NA NA hsa-miR-148a-5p JUN 1.31769244477686 0.0507400532963856 -1.39678224976456 0.0210065056705043 miRNATAP -0.129131851809151 0.0113389669745006 NA NA NA hsa-miR-200c-3p JUN 6.47012025883743 2.64500707716408e-26 -1.39678224976456 0.0210065056705043 MirTarget -0.119095512777692 0.0217712883284784 NA NA NA hsa-miR-30a-5p JUN -0.768430903969183 0.320487552854215 -1.39678224976456 0.0210065056705043 miRNAWalker2_validate -0.152843415788565 0.000559974108995951 NA NA NA hsa-miR-501-5p JUN 1.0411896821345 0.0777206709183552 -1.39678224976456 0.0210065056705043 MirTarget;PITA;miRNATAP -0.125358323229356 0.0321926396153119 NA NA NA hsa-miR-92b-3p JUN 1.69303761469782 0.0103484911955574 -1.39678224976456 0.0210065056705043 miRNATAP -0.111823818307455 0.0317381073239254 NA NA NA hsa-miR-93-5p JUN 2.65964181833033 2.58315947526774e-08 -1.39678224976456 0.0210065056705043 miRNAWalker2_validate -0.178258386689689 0.0119642833972811 NA NA NA hsa-let-7b-3p LEF1 0.589364128513318 0.200507534602851 -1.06801208642423 0.21098542163647 miRNATAP -0.245216116896237 0.0210832331663377 NA NA NA hsa-miR-193b-3p LEF1 1.35015762547152 0.0874921379319504 -1.06801208642423 0.21098542163647 miRNAWalker2_validate -0.349322384823671 5.36528724241979e-09 NA NA NA hsa-miR-3065-5p LEF1 2.14185373842821 0.0609400502269891 -1.06801208642423 0.21098542163647 miRNATAP -0.111251167613828 0.0349628158843912 NA NA NA hsa-miR-320c LEF1 -0.10618808730545 0.854002814666472 -1.06801208642423 0.21098542163647 miRanda;mirMAP -0.172684355350552 0.0449648961016132 NA NA NA hsa-miR-330-5p LEF1 2.25110496739954 0.000275527655397415 -1.06801208642423 0.21098542163647 miRanda -0.403439067915215 1.29300750911004e-07 NA NA NA hsa-miR-335-3p LEF1 1.19503568251824 0.0938852560631551 -1.06801208642423 0.21098542163647 mirMAP -0.149385269199291 0.0279703941176107 NA NA NA hsa-miR-23b-3p LRP5 -0.581135273821923 0.190478897170459 -0.595959399367886 0.240924557326017 MirTarget;miRNATAP -0.218346439327815 0.000821970690502326 NA NA NA hsa-let-7a-3p LRP6 0.82512001802525 0.0468122405194487 -1.5108432620961 0.00142291856207554 miRNATAP -0.239522877911242 0.000250601301585231 NA NA NA hsa-let-7b-3p LRP6 0.589364128513318 0.200507534602851 -1.5108432620961 0.00142291856207554 miRNATAP -0.191745599906589 0.00115669494820718 NA NA NA hsa-miR-15a-5p LRP6 2.0535411006904 1.91108976398046e-06 -1.5108432620961 0.00142291856207554 miRNATAP -0.165773696022836 0.00773102096168767 NA NA NA hsa-miR-15b-3p LRP6 3.57530146629867 5.89922785773482e-11 -1.5108432620961 0.00142291856207554 mirMAP -0.126415824983402 0.0085095996610987 NA NA NA hsa-miR-16-1-3p LRP6 2.83281226969693 7.54359864580834e-09 -1.5108432620961 0.00142291856207554 mirMAP -0.230596673066301 1.66697104506246e-05 NA NA NA hsa-miR-16-2-3p LRP6 3.79845098071094 1.49120139344659e-13 -1.5108432620961 0.00142291856207554 mirMAP -0.226119881614063 6.32525687825393e-06 NA NA NA hsa-miR-16-5p LRP6 2.93575808220754 2.15436817162977e-10 -1.5108432620961 0.00142291856207554 miRNATAP -0.184141529083919 0.00122049498427303 NA NA NA hsa-miR-193a-3p LRP6 0.646392169474854 0.207134343676122 -1.5108432620961 0.00142291856207554 miRanda -0.196481989769693 0.000194121112974321 NA NA NA hsa-miR-205-5p LRP6 8.08298115900323 3.83045179398654e-07 -1.5108432620961 0.00142291856207554 miRNATAP -0.121996879175874 1.57174972800956e-14 NA NA NA hsa-miR-221-3p LRP6 0.94082283577318 0.174749164179978 -1.5108432620961 0.00142291856207554 miRNAWalker2_validate -0.337661590536743 2.94261432714232e-20 NA NA NA hsa-miR-224-3p LRP6 2.84876340814503 0.000179138399939161 -1.5108432620961 0.00142291856207554 mirMAP -0.135889711951014 0.000113019503836657 NA NA NA hsa-miR-29a-3p LRP6 -0.638239697975974 0.251923581881716 -1.5108432620961 0.00142291856207554 miRNATAP -0.209015898037184 1.46286019821099e-05 NA NA NA hsa-miR-29b-3p LRP6 0.666547117072858 0.234055379278093 -1.5108432620961 0.00142291856207554 miRNATAP -0.272342890317397 9.20343798939943e-09 NA NA NA hsa-miR-29c-3p LRP6 -0.414153610337085 0.529344128062017 -1.5108432620961 0.00142291856207554 miRNATAP -0.165154148934994 5.14844928361703e-05 NA NA NA hsa-miR-330-3p LRP6 2.49094236945806 0.000129367003214715 -1.5108432620961 0.00142291856207554 PITA;mirMAP;miRNATAP -0.135466896435882 0.000986178094432534 NA NA NA hsa-miR-590-3p LRP6 2.35429565068338 2.79601879608564e-06 -1.5108432620961 0.00142291856207554 PITA;miRanda;miRNATAP -0.271209115892361 2.21823124321968e-07 NA NA NA hsa-miR-29a-5p MAP3K7 0.0748295222568571 0.884125894063293 0.316391433469006 0.292968544589595 mirMAP -0.123297042652905 0.000192527325272211 NA NA NA hsa-miR-34a-5p MAP3K7 0.830377770217786 0.0477544831885907 0.316391433469006 0.292968544589595 miRNAWalker2_validate -0.115410514352201 0.00466228094371235 NA NA NA hsa-miR-664a-3p MAP3K7 0.249882351950296 0.56171157318348 0.316391433469006 0.292968544589595 MirTarget;mirMAP -0.129722952536066 0.00109384610601403 NA NA NA hsa-miR-125a-3p MAPK10 -0.0748960586927341 0.920735897434087 -4.02861810775413 0.000455327611153647 miRanda;miRNATAP -0.214484762458325 0.0144586507821837 NA NA NA hsa-miR-130b-3p MAPK10 3.9204771543282 1.2714917955808e-11 -4.02861810775413 0.000455327611153647 miRNATAP -0.289477401545203 0.00852945933118219 NA NA NA hsa-miR-193a-3p MAPK10 0.646392169474854 0.207134343676122 -4.02861810775413 0.000455327611153647 miRanda;miRNATAP -0.422086807842181 0.00104846344400487 NA NA NA hsa-miR-19a-3p MAPK10 2.17020503944519 0.00122084653711062 -4.02861810775413 0.000455327611153647 miRNATAP -0.361656353314988 0.000189541931048248 NA NA NA hsa-miR-19b-3p MAPK10 1.67581705793313 0.000858910586302716 -4.02861810775413 0.000455327611153647 miRNATAP -0.607554128693399 2.5291087868802e-06 NA NA NA hsa-miR-301a-3p MAPK10 1.99338115332667 0.000813358604963724 -4.02861810775413 0.000455327611153647 miRNATAP -0.54512724483879 4.88085213693914e-07 NA NA NA hsa-miR-30d-3p MAPK10 -0.0740421896025512 0.857423650167556 -4.02861810775413 0.000455327611153647 mirMAP -0.359608169240653 0.0266123304870971 NA NA NA hsa-miR-330-3p MAPK10 2.49094236945806 0.000129367003214715 -4.02861810775413 0.000455327611153647 PITA;miRNATAP -0.227150304468134 0.0240336552533418 NA NA NA hsa-miR-454-3p MAPK10 1.40269869979902 0.00366085847011367 -4.02861810775413 0.000455327611153647 miRNATAP -0.574589535977024 2.1903057455657e-05 NA NA NA hsa-miR-582-5p MAPK10 0.685177900016753 0.447761540297692 -4.02861810775413 0.000455327611153647 PITA -0.23346088711947 0.00130125193601691 NA NA NA hsa-miR-590-5p MAPK10 1.51400888103768 0.0023888567923017 -4.02861810775413 0.000455327611153647 PITA;miRanda;miRNATAP -0.336539835321851 0.0108511072137111 NA NA NA hsa-miR-29a-5p MAPK8 0.0748295222568571 0.884125894063293 0.782437648754587 0.218394219235169 mirMAP -0.207086809669531 0.00336154577686051 NA NA NA hsa-miR-374a-3p MAPK8 0.465360399099794 0.305267458251279 0.782437648754587 0.218394219235169 mirMAP -0.166283811245297 0.0385366678809424 NA NA NA hsa-miR-590-3p MAPK8 2.35429565068338 2.79601879608564e-06 0.782437648754587 0.218394219235169 miRNATAP -0.170264668628768 0.0166011773867137 NA NA NA hsa-miR-708-3p MAPK8 0.781444321399141 0.290645825716608 0.782437648754587 0.218394219235169 mirMAP -0.100612177276098 0.0394297973877395 NA NA NA hsa-miR-374b-5p MAPK9 -0.114749866169918 0.764888930049438 -0.0838789835475646 0.763171653828229 mirMAP -0.10438169303407 0.0119183558910399 NA NA NA hsa-miR-590-3p MMP7 2.35429565068338 2.79601879608564e-06 -3.04326127961044 0.0749319303420266 miRanda -0.499481287241256 0.00907848518433902 NA NA NA hsa-miR-590-5p MMP7 1.51400888103768 0.0023888567923017 -3.04326127961044 0.0749319303420266 miRanda -0.64908021008509 0.000837452656727188 NA NA NA hsa-miR-335-5p MYC 0.167216045757305 0.803897055331049 -0.745260197790044 0.453852120838847 miRNAWalker2_validate -0.177349242383061 0.0350467132879494 NA NA NA hsa-miR-34a-5p MYC 0.830377770217786 0.0477544831885907 -0.745260197790044 0.453852120838847 miRNAWalker2_validate;miRTarBase -0.427487830189717 0.00161403194033986 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 6.39965293994036 1.96920201593608e-18 -0.745260197790044 0.453852120838847 miRNAWalker2_validate -0.351232938868747 9.84375821791447e-07 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-let-7a-3p NFAT5 0.82512001802525 0.0468122405194487 -0.873812260090285 0.0142802458392285 MirTarget;mirMAP;miRNATAP -0.118683707563695 0.0160211494802928 NA NA NA hsa-miR-148b-3p NFAT5 1.75622244535669 8.84414356040579e-08 -0.873812260090285 0.0142802458392285 miRNATAP -0.129917912391227 0.0354982059138115 NA NA NA hsa-miR-148b-5p NFAT5 2.80812018666078 3.97536665756679e-08 -0.873812260090285 0.0142802458392285 MirTarget -0.100855866248161 0.00959701643950966 NA NA NA hsa-miR-15b-3p NFAT5 3.57530146629867 5.89922785773482e-11 -0.873812260090285 0.0142802458392285 mirMAP -0.126013171880713 0.000433697196258896 NA NA NA hsa-miR-16-1-3p NFAT5 2.83281226969693 7.54359864580834e-09 -0.873812260090285 0.0142802458392285 mirMAP -0.130238828931912 0.00125292308133802 NA NA NA hsa-miR-21-3p NFAT5 3.50297439576639 6.39946844099206e-10 -0.873812260090285 0.0142802458392285 MirTarget -0.118527852125061 0.000620164790667205 NA NA NA hsa-miR-25-3p NFAT5 1.12623030168869 0.00311079344417173 -0.873812260090285 0.0142802458392285 miRNATAP -0.223695548560318 2.57174109236902e-05 NA NA NA hsa-miR-27b-5p NFAT5 0.213392605793392 0.71562473353293 -0.873812260090285 0.0142802458392285 miRNATAP -0.110179611906402 0.00144077959452122 NA NA NA hsa-miR-361-3p NFAT5 0.805698609170807 0.0418491665498322 -0.873812260090285 0.0142802458392285 MirTarget;PITA;miRNATAP -0.144768979044564 0.0050756704455289 NA NA NA hsa-miR-3613-5p NFAT5 4.05007522786126 4.52786477176299e-14 -0.873812260090285 0.0142802458392285 miRNATAP -0.104413571822805 0.00388544536937255 NA NA NA hsa-miR-374a-3p NFAT5 0.465360399099794 0.305267458251279 -0.873812260090285 0.0142802458392285 mirMAP -0.129458904757358 0.00396424743551628 NA NA NA hsa-miR-421 NFATC1 1.97624148591545 0.000915838012451138 -1.43554817723087 0.0336971295728903 miRanda -0.150167602829739 0.0197873632705183 NA NA NA hsa-miR-940 NFATC1 3.78496690968119 4.75227557809023e-05 -1.43554817723087 0.0336971295728903 PITA -0.102847748261407 0.0398722601946341 NA NA NA hsa-miR-16-2-3p NFATC2 3.79845098071094 1.49120139344659e-13 -0.286059700331541 0.82399568318191 mirMAP -0.505831882428398 0.000198875188682268 NA NA NA hsa-miR-182-5p NFATC2 5.86988712704738 1.22411588571584e-15 -0.286059700331541 0.82399568318191 mirMAP -0.32144165425718 0.000646026696926626 NA NA NA hsa-miR-193b-5p NFATC2 0.448438597554777 0.565875535989548 -0.286059700331541 0.82399568318191 MirTarget -0.238768177822067 0.0105859005051556 NA NA NA hsa-miR-19b-3p NFATC2 1.67581705793313 0.000858910586302716 -0.286059700331541 0.82399568318191 mirMAP -0.404387130112085 0.00521651290699105 NA NA NA hsa-miR-221-3p NFATC2 0.94082283577318 0.174749164179978 -0.286059700331541 0.82399568318191 MirTarget -0.377449174577961 0.000312614420924495 NA NA NA hsa-miR-222-3p NFATC2 1.54730827524553 0.0223014220569407 -0.286059700331541 0.82399568318191 MirTarget -0.397758818078019 0.000197967348333277 NA NA NA hsa-miR-2355-3p NFATC2 0.494099635633886 0.483724014019781 -0.286059700331541 0.82399568318191 mirMAP -0.226883045616803 0.0288946270049332 NA NA NA hsa-miR-2355-5p NFATC2 0.418226038913005 0.502149040287915 -0.286059700331541 0.82399568318191 MirTarget -0.399238734977261 0.000639415285590298 NA NA NA hsa-miR-24-3p NFATC2 1.55853749533999 0.000524726461381821 -0.286059700331541 0.82399568318191 MirTarget -0.468867821397621 0.00386071331628823 NA NA NA hsa-miR-26b-3p NFATC2 0.985177548213122 0.0351427970185971 -0.286059700331541 0.82399568318191 MirTarget -0.424161999476118 0.00685427841775268 NA NA NA hsa-miR-27b-5p NFATC2 0.213392605793392 0.71562473353293 -0.286059700331541 0.82399568318191 mirMAP -0.562887952208124 5.3203758057189e-06 NA NA NA hsa-miR-30b-3p NFATC2 0.169674321578618 0.766080356926625 -0.286059700331541 0.82399568318191 MirTarget -0.322287098449763 0.0126270628966372 NA NA NA hsa-miR-30b-5p NFATC2 0.0238659735605804 0.953223658270319 -0.286059700331541 0.82399568318191 MirTarget;mirMAP -0.701664889521975 0.000103150761633541 NA NA NA hsa-miR-31-3p NFATC2 5.7035081317825 2.15133648211091e-05 -0.286059700331541 0.82399568318191 MirTarget -0.165285210332694 0.0118406224525874 NA NA NA hsa-miR-320a NFATC2 -0.912036444869976 0.0565555443926988 -0.286059700331541 0.82399568318191 MirTarget -0.346113229605566 0.024282863992267 NA NA NA hsa-miR-335-3p NFATC2 1.19503568251824 0.0938852560631551 -0.286059700331541 0.82399568318191 mirMAP -0.275457201424799 0.00698833780307122 NA NA NA hsa-miR-33a-3p NFATC2 2.06269680799532 0.00156436055383943 -0.286059700331541 0.82399568318191 mirMAP -0.49218710815049 8.56348757093332e-06 NA NA NA hsa-miR-3607-3p NFATC2 1.38015131722213 0.0240067155694847 -0.286059700331541 0.82399568318191 MirTarget;mirMAP -0.391336207534776 0.000990733127382603 NA NA NA hsa-miR-378a-5p NFATC2 1.25775140086104 0.0500877723587615 -0.286059700331541 0.82399568318191 miRNATAP -0.251797696745009 0.0268776878480696 NA NA NA hsa-miR-423-5p NFATC2 0.227366878624794 0.5653498335202 -0.286059700331541 0.82399568318191 PITA -0.441645638359424 0.0185055105961266 NA NA NA hsa-miR-484 NFATC2 1.79050445056016 0.000217287101253701 -0.286059700331541 0.82399568318191 MirTarget -0.311088837253416 0.0388559264488738 NA NA NA hsa-miR-590-3p NFATC2 2.35429565068338 2.79601879608564e-06 -0.286059700331541 0.82399568318191 mirMAP -0.384051398639096 0.00750996376662493 NA NA NA hsa-miR-9-5p NFATC2 1.79620806707734 0.14526963042518 -0.286059700331541 0.82399568318191 MirTarget -0.179640503569894 0.00223258011764884 NA NA NA hsa-miR-29a-3p NFATC3 -0.638239697975974 0.251923581881716 0.477055216934867 0.106796631983734 MirTarget;miRNATAP -0.140468120986745 2.25586419429949e-06 NA NA NA hsa-miR-30a-5p NFATC3 -0.768430903969183 0.320487552854215 0.477055216934867 0.106796631983734 MirTarget;miRNATAP -0.10800426830215 3.64017456454683e-07 NA NA NA hsa-miR-30b-5p NFATC3 0.0238659735605804 0.953223658270319 0.477055216934867 0.106796631983734 MirTarget;miRNATAP -0.10595010710119 0.0109106085755724 NA NA NA hsa-miR-505-3p NFATC3 0.58881333170866 0.226937454637888 0.477055216934867 0.106796631983734 mirMAP -0.101422391581702 0.00323042227101925 NA NA NA hsa-miR-150-5p NFATC4 1.76769157530064 0.0593795975117846 -3.51227827619475 3.3529829198664e-05 mirMAP -0.102245588799473 0.0484410590735606 NA NA NA hsa-miR-15b-3p NFATC4 3.57530146629867 5.89922785773482e-11 -3.51227827619475 3.3529829198664e-05 mirMAP -0.332671458598109 0.000109614721294728 NA NA NA hsa-miR-193a-3p NFATC4 0.646392169474854 0.207134343676122 -3.51227827619475 3.3529829198664e-05 miRanda -0.331963642605815 0.000483436127300785 NA NA NA hsa-miR-2355-5p NFATC4 0.418226038913005 0.502149040287915 -3.51227827619475 3.3529829198664e-05 MirTarget -0.222270601628068 0.00449762571989068 NA NA NA hsa-miR-29b-3p NFATC4 0.666547117072858 0.234055379278093 -3.51227827619475 3.3529829198664e-05 miRNATAP -0.269565814376398 0.0019545991736415 NA NA NA hsa-miR-484 NFATC4 1.79050445056016 0.000217287101253701 -3.51227827619475 3.3529829198664e-05 MirTarget;miRNATAP -0.333356851887072 0.000848337680097208 NA NA NA hsa-miR-629-3p NFATC4 3.48282157979573 4.9176538695908e-08 -3.51227827619475 3.3529829198664e-05 mirMAP -0.452159715701377 5.06669620050464e-10 NA NA NA hsa-let-7a-5p NKD1 0.148081801547773 0.645305441523746 -1.98089063442873 0.0698165327979292 TargetScan -0.5394886488876 0.0064772239484111 NA NA NA hsa-miR-200b-3p NKD1 5.56167217794639 6.43540045061709e-16 -1.98089063442873 0.0698165327979292 TargetScan -0.246261562772618 0.00407083131720379 NA NA NA hsa-miR-330-5p NKD1 2.25110496739954 0.000275527655397415 -1.98089063442873 0.0698165327979292 miRanda;miRNATAP -0.323051116539652 0.00114414069657017 NA NA NA hsa-miR-944 NKD1 7.20925181386398 0.000823207457340648 -1.98089063442873 0.0698165327979292 PITA;miRNATAP -0.104617511964737 0.00313578391544455 NA NA NA hsa-let-7a-5p NLK 0.148081801547773 0.645305441523746 0.183543839079865 0.498710830211101 TargetScan;miRNATAP -0.117940531582138 0.0154895017806529 NA NA NA hsa-let-7b-5p NLK -0.189422992330471 0.651878220048983 0.183543839079865 0.498710830211101 miRNATAP -0.114257517524189 0.00186376055418449 NA NA NA hsa-let-7i-5p NLK 0.0473185312396307 0.869714142234765 0.183543839079865 0.498710830211101 miRNATAP -0.166463992572848 0.00230814976045761 NA NA NA hsa-miR-152-3p NLK 0.0996927696128376 0.867443498706607 0.183543839079865 0.498710830211101 MirTarget -0.100005908022808 8.57051397147721e-05 NA NA NA hsa-miR-221-3p NLK 0.94082283577318 0.174749164179978 0.183543839079865 0.498710830211101 MirTarget;miRNATAP -0.15407716283403 3.74272091558852e-13 NA NA NA hsa-miR-222-3p NLK 1.54730827524553 0.0223014220569407 0.183543839079865 0.498710830211101 MirTarget;miRNATAP -0.141074145632073 1.08276456992864e-10 NA NA NA hsa-miR-222-5p NLK 2.52056758362407 0.00142010793166944 0.183543839079865 0.498710830211101 MirTarget -0.122397786918054 5.03934994367364e-11 NA NA NA hsa-miR-23a-3p NLK 0.925125296618358 0.0127293543936914 0.183543839079865 0.498710830211101 miRNAWalker2_validate;MirTarget -0.111655445486474 0.00729490375203523 NA NA NA hsa-miR-27a-3p NLK 1.76094007417453 0.000216137556256765 0.183543839079865 0.498710830211101 miRNATAP -0.114442011738111 0.000322691345608444 NA NA NA hsa-miR-27b-3p NLK -0.0929089601968123 0.85847352206581 0.183543839079865 0.498710830211101 miRNATAP -0.105967873572703 0.000302277506931224 NA NA NA hsa-miR-342-3p NLK 1.31107714473009 0.0207211910724662 0.183543839079865 0.498710830211101 miRanda -0.124078682939925 3.10194434150662e-06 NA NA NA hsa-miR-142-3p PLCB1 4.35304505457969 3.10014573651358e-10 -1.81436884275205 0.0723908178314423 PITA;miRanda;miRNATAP -0.212315328629979 0.00837775415657827 NA NA NA hsa-miR-16-2-3p PLCB1 3.79845098071094 1.49120139344659e-13 -1.81436884275205 0.0723908178314423 mirMAP -0.319591138268826 0.00293151934803552 NA NA NA hsa-miR-17-5p PLCB1 2.3269271449522 2.13987445663942e-05 -1.81436884275205 0.0723908178314423 TargetScan;miRNATAP -0.223582633887522 0.0317200496039695 NA NA NA hsa-miR-19a-3p PLCB1 2.17020503944519 0.00122084653711062 -1.81436884275205 0.0723908178314423 miRNATAP -0.21720922887978 0.0106280087963297 NA NA NA hsa-miR-19b-3p PLCB1 1.67581705793313 0.000858910586302716 -1.81436884275205 0.0723908178314423 miRNATAP -0.295421515419568 0.00957725380883961 NA NA NA hsa-miR-205-5p PLCB1 8.08298115900323 3.83045179398654e-07 -1.81436884275205 0.0723908178314423 miRNATAP -0.179652575957285 2.1239580128762e-07 NA NA NA hsa-miR-20a-5p PLCB1 2.13553469875764 0.000181201072324354 -1.81436884275205 0.0723908178314423 miRNATAP -0.26240485806214 0.00867556441357238 NA NA NA hsa-miR-330-3p PLCB1 2.49094236945806 0.000129367003214715 -1.81436884275205 0.0723908178314423 PITA;mirMAP -0.200841435184285 0.0221539523173093 NA NA NA hsa-miR-340-5p PLCB1 1.41210478721579 0.00958612942879818 -1.81436884275205 0.0723908178314423 mirMAP -0.224208907518659 0.0339305321564128 NA NA NA hsa-miR-452-5p PLCB1 2.45466810475361 0.00114794259949532 -1.81436884275205 0.0723908178314423 mirMAP -0.158248794805154 0.0363082074177606 NA NA NA hsa-miR-454-3p PLCB1 1.40269869979902 0.00366085847011367 -1.81436884275205 0.0723908178314423 miRNATAP -0.301282833324502 0.0114831149932522 NA NA NA hsa-miR-590-3p PLCB1 2.35429565068338 2.79601879608564e-06 -1.81436884275205 0.0723908178314423 PITA;miRanda;mirMAP -0.294674248424645 0.00916966691382528 NA NA NA hsa-miR-7-5p PLCB1 3.59831747997243 0.000676336260217879 -1.81436884275205 0.0723908178314423 miRNATAP -0.14340627359631 0.0307872006503479 NA NA NA hsa-miR-9-5p PLCB1 1.79620806707734 0.14526963042518 -1.81436884275205 0.0723908178314423 mirMAP -0.176761177372917 0.000123296624676458 NA NA NA hsa-miR-944 PLCB1 7.20925181386398 0.000823207457340648 -1.81436884275205 0.0723908178314423 PITA;mirMAP -0.167328508617809 2.12356997210001e-07 NA NA NA hsa-miR-339-5p PLCB2 1.23326828594484 0.0307501214818698 0.77644224160473 0.211773245983525 miRanda -0.147157642046453 0.0174135238375772 NA NA NA hsa-miR-125a-5p PLCB3 -1.32352790615388 0.00714301627309467 0.800148438430191 0.0112406480827997 miRanda -0.147616652879399 4.39424570802659e-05 NA NA NA hsa-let-7a-3p PLCB4 0.82512001802525 0.0468122405194487 -3.38039309710074 0.0401436033746677 mirMAP;miRNATAP -0.506630984901783 0.0266778511818392 NA NA NA hsa-let-7b-3p PLCB4 0.589364128513318 0.200507534602851 -3.38039309710074 0.0401436033746677 mirMAP;miRNATAP -0.657857764169289 0.00132070975922559 NA NA NA hsa-let-7b-5p PLCB4 -0.189422992330471 0.651878220048983 -3.38039309710074 0.0401436033746677 miRNATAP -0.5486126054687 0.0153901530827988 NA NA NA hsa-let-7f-1-3p PLCB4 1.61507869803314 0.00069342464777815 -3.38039309710074 0.0401436033746677 mirMAP -0.884179425801791 6.21055620952821e-06 NA NA NA hsa-let-7f-5p PLCB4 0.971961126099146 0.0240319857511033 -3.38039309710074 0.0401436033746677 miRNATAP -0.526194765473155 0.0165863361999513 NA NA NA hsa-miR-16-2-3p PLCB4 3.79845098071094 1.49120139344659e-13 -3.38039309710074 0.0401436033746677 mirMAP -0.582623974128612 0.000878230710514813 NA NA NA hsa-miR-23a-3p PLCB4 0.925125296618358 0.0127293543936914 -3.38039309710074 0.0401436033746677 miRNATAP -1.56589918570536 3.30417922796892e-10 NA NA NA hsa-miR-9-5p PLCB4 1.79620806707734 0.14526963042518 -3.38039309710074 0.0401436033746677 miRNAWalker2_validate;mirMAP -0.223672340449135 0.00306945439314662 NA NA NA hsa-miR-944 PLCB4 7.20925181386398 0.000823207457340648 -3.38039309710074 0.0401436033746677 mirMAP -0.501409266104758 5.5378576748897e-24 NA NA NA hsa-miR-194-3p PPARD 1.91743783341496 0.105383373371284 0.419455821740777 0.283177127294337 MirTarget -0.104075771818383 1.47684555551408e-08 NA NA NA hsa-miR-28-5p PPARD -0.815636722979196 0.0221199948901761 0.419455821740777 0.283177127294337 mirMAP -0.192602555264515 0.00218745384817617 NA NA NA hsa-miR-423-5p PPARD 0.227366878624794 0.5653498335202 0.419455821740777 0.283177127294337 MirTarget;mirMAP -0.121175923928577 0.0330245649196417 NA NA NA hsa-miR-497-5p PPARD -1.44150596209372 0.0225146607606395 0.419455821740777 0.283177127294337 mirMAP -0.104197870658577 0.00280618926025624 NA NA NA hsa-miR-425-5p PPP2CB 3.15197291080781 3.16652350906107e-07 -1.25447828974493 1.05312923428955e-05 miRNAWalker2_validate -0.110681790089799 1.64448494638146e-05 NA NA NA hsa-miR-590-3p PPP2CB 2.35429565068338 2.79601879608564e-06 -1.25447828974493 1.05312923428955e-05 miRanda -0.128757858804767 5.16847568396067e-05 NA NA NA hsa-miR-125a-5p PPP2R1B -1.32352790615388 0.00714301627309467 0.535943295428266 0.162251997298493 PITA;miRanda -0.114930033410317 0.00930190483964423 NA NA NA hsa-miR-30e-3p PPP2R1B -0.0362193022195196 0.932577027239525 0.535943295428266 0.162251997298493 mirMAP -0.109171912123649 0.0336857613488188 NA NA NA hsa-miR-452-5p PPP2R1B 2.45466810475361 0.00114794259949532 0.535943295428266 0.162251997298493 MirTarget -0.106017919286185 0.000183245518742969 NA NA NA hsa-miR-107 PPP2R5A 1.49443409571439 0.000130594521065411 -0.140489073340774 0.671690982688938 miRanda -0.144398642769006 0.00260012205894746 NA NA NA hsa-miR-186-5p PPP2R5C 0.445443449112564 0.185447310527704 -0.316038762242836 0.26720752514426 mirMAP;miRNATAP -0.180523874486163 0.000196249408190972 NA NA NA hsa-miR-101-5p PPP2R5E -1.41522721523565 0.0166784131265028 0.535525914733393 0.120928926594593 MirTarget -0.180690176030252 2.46208790792195e-08 NA NA NA hsa-miR-125a-5p PPP2R5E -1.32352790615388 0.00714301627309467 0.535525914733393 0.120928926594593 miRNAWalker2_validate -0.179165818069827 5.17839779064056e-06 NA NA NA hsa-miR-181c-5p PPP2R5E -0.302833440762172 0.537532549455539 0.535525914733393 0.120928926594593 MirTarget;mirMAP -0.16820871881031 2.25744067324159e-05 NA NA NA hsa-miR-195-3p PPP2R5E -2.39100534119332 0.000185405399054065 0.535525914733393 0.120928926594593 mirMAP -0.121161783375062 6.09529627319605e-05 NA NA NA hsa-miR-29b-2-5p PPP2R5E -0.596051745078872 0.189540844841389 0.535525914733393 0.120928926594593 mirMAP -0.240263449414642 1.5497933709251e-08 NA NA NA hsa-miR-30a-5p PPP2R5E -0.768430903969183 0.320487552854215 0.535525914733393 0.120928926594593 mirMAP -0.111068835600136 8.55978751796861e-06 NA NA NA hsa-miR-30b-5p PPP2R5E 0.0238659735605804 0.953223658270319 0.535525914733393 0.120928926594593 mirMAP -0.149474692025846 0.00208479541033403 NA NA NA hsa-miR-30c-5p PPP2R5E 0.38723991118075 0.348605235643473 0.535525914733393 0.120928926594593 mirMAP -0.101237468382287 0.034771931268642 NA NA NA hsa-miR-30d-3p PPP2R5E -0.0740421896025512 0.857423650167556 0.535525914733393 0.120928926594593 MirTarget -0.144308649360449 0.00260698547448653 NA NA NA hsa-miR-30e-3p PPP2R5E -0.0362193022195196 0.932577027239525 0.535525914733393 0.120928926594593 MirTarget -0.119486384973344 0.00965259842012976 NA NA NA hsa-miR-30e-5p PPP2R5E 0.780047227271616 0.0346714425913016 0.535525914733393 0.120928926594593 mirMAP -0.190433556521116 0.000361265009878909 NA NA NA hsa-miR-3607-3p PPP2R5E 1.38015131722213 0.0240067155694847 0.535525914733393 0.120928926594593 mirMAP;miRNATAP -0.102503532433218 0.00126886534770206 NA NA NA hsa-miR-374b-5p PPP2R5E -0.114749866169918 0.764888930049438 0.535525914733393 0.120928926594593 mirMAP -0.141522657991467 0.00619666437031856 NA NA NA hsa-let-7g-5p PPP3CA 0.857251702023746 0.00647597344297273 -0.0994691469518081 0.767527156115313 miRNATAP -0.161347150543761 0.00879795113322894 NA NA NA hsa-miR-361-3p PPP3CA 0.805698609170807 0.0418491665498322 -0.0994691469518081 0.767527156115313 MirTarget;PITA;miRNATAP -0.1244680543674 0.0103177804265776 NA NA NA hsa-miR-141-3p PRICKLE1 7.30474126597325 1.45115996357606e-24 -3.02552871002129 0.00131232153959817 TargetScan -0.398898827959149 4.4175751955465e-09 NA NA NA hsa-miR-17-5p PRICKLE1 2.3269271449522 2.13987445663942e-05 -3.02552871002129 0.00131232153959817 miRNAWalker2_validate -0.271468501852006 0.00529473692424031 NA NA NA hsa-miR-192-5p PRICKLE1 1.77716187978541 0.113485496183047 -3.02552871002129 0.00131232153959817 miRNAWalker2_validate -0.257468457622056 3.84362272784163e-08 NA NA NA hsa-miR-215-5p PRICKLE1 3.66990923176752 0.00294614570694381 -3.02552871002129 0.00131232153959817 miRNAWalker2_validate -0.255545939161005 1.42291724246968e-09 NA NA NA hsa-miR-3065-5p PRICKLE1 2.14185373842821 0.0609400502269891 -3.02552871002129 0.00131232153959817 mirMAP -0.152694399920415 0.00903665256532244 NA NA NA hsa-miR-30b-5p PRICKLE1 0.0238659735605804 0.953223658270319 -3.02552871002129 0.00131232153959817 mirMAP -0.376398378671489 0.00500957386454352 NA NA NA hsa-miR-30d-5p PRICKLE1 0.302504510257496 0.380193536606962 -3.02552871002129 0.00131232153959817 miRNATAP -0.381032706916074 0.0170568221131939 NA NA NA hsa-miR-330-3p PRICKLE1 2.49094236945806 0.000129367003214715 -3.02552871002129 0.00131232153959817 mirMAP;miRNATAP -0.206472543563517 0.0120583834774765 NA NA NA hsa-miR-338-3p PRICKLE1 0.447551118940466 0.558485097370031 -3.02552871002129 0.00131232153959817 miRanda -0.220142690785802 0.0017159550637653 NA NA NA hsa-miR-3607-3p PRICKLE1 1.38015131722213 0.0240067155694847 -3.02552871002129 0.00131232153959817 miRNATAP -0.19393525615551 0.0277443863634634 NA NA NA hsa-miR-532-5p PRICKLE1 -0.297424983759107 0.503934707453099 -3.02552871002129 0.00131232153959817 miRNATAP -0.306192915015153 0.0123149977914733 NA NA NA hsa-miR-582-5p PRICKLE1 0.685177900016753 0.447761540297692 -3.02552871002129 0.00131232153959817 miRNATAP -0.232483699486703 8.43679696263967e-05 NA NA NA hsa-let-7a-3p PRICKLE2 0.82512001802525 0.0468122405194487 -3.45141746786942 2.23819194762863e-06 mirMAP -0.215161295987859 0.0361475980891375 NA NA NA hsa-let-7b-3p PRICKLE2 0.589364128513318 0.200507534602851 -3.45141746786942 2.23819194762863e-06 mirMAP -0.246312978579838 0.00756229568470298 NA NA NA hsa-let-7f-1-3p PRICKLE2 1.61507869803314 0.00069342464777815 -3.45141746786942 2.23819194762863e-06 mirMAP -0.308078106997812 0.000495101004435929 NA NA NA hsa-let-7f-2-3p PRICKLE2 1.02768112108475 0.0787293499732611 -3.45141746786942 2.23819194762863e-06 mirMAP -0.189415412416402 0.0103479731951483 NA NA NA hsa-miR-146a-5p PRICKLE2 2.64646698525354 0.000280611928973036 -3.45141746786942 2.23819194762863e-06 mirMAP -0.160745001027756 0.00493178107285413 NA NA NA hsa-miR-148b-3p PRICKLE2 1.75622244535669 8.84414356040579e-08 -3.45141746786942 2.23819194762863e-06 MirTarget;miRNATAP -0.428977213345021 0.000796450369894216 NA NA NA hsa-miR-150-5p PRICKLE2 1.76769157530064 0.0593795975117846 -3.45141746786942 2.23819194762863e-06 MirTarget -0.130596972874792 0.00344135932488411 NA NA NA hsa-miR-15b-3p PRICKLE2 3.57530146629867 5.89922785773482e-11 -3.45141746786942 2.23819194762863e-06 mirMAP -0.305418579191281 3.91799008722286e-05 NA NA NA hsa-miR-16-2-3p PRICKLE2 3.79845098071094 1.49120139344659e-13 -3.45141746786942 2.23819194762863e-06 mirMAP -0.394528740870726 3.82910940604498e-07 NA NA NA hsa-miR-182-5p PRICKLE2 5.86988712704738 1.22411588571584e-15 -3.45141746786942 2.23819194762863e-06 MirTarget -0.116662595040934 0.0328987119370907 NA NA NA hsa-miR-18a-5p PRICKLE2 3.90770175770219 9.15298615034137e-10 -3.45141746786942 2.23819194762863e-06 MirTarget -0.186919696461069 0.00354397953056611 NA NA NA hsa-miR-19b-3p PRICKLE2 1.67581705793313 0.000858910586302716 -3.45141746786942 2.23819194762863e-06 MirTarget;miRNATAP -0.186886301013662 0.0256169965796081 NA NA NA hsa-miR-203a-3p PRICKLE2 6.35084246337388 7.89944323347948e-08 -3.45141746786942 2.23819194762863e-06 MirTarget -0.143413825673005 3.04290466636865e-05 NA NA NA hsa-miR-21-5p PRICKLE2 2.65163477806992 6.72089787690756e-16 -3.45141746786942 2.23819194762863e-06 miRNAWalker2_validate;MirTarget -0.411551709864877 0.000912823366410808 NA NA NA hsa-miR-221-5p PRICKLE2 2.07459535854377 0.0757339015356929 -3.45141746786942 2.23819194762863e-06 MirTarget -0.112767891096494 0.00182590919526375 NA NA NA hsa-miR-224-3p PRICKLE2 2.84876340814503 0.000179138399939161 -3.45141746786942 2.23819194762863e-06 mirMAP -0.11703560848566 0.0343691447313502 NA NA NA hsa-miR-27a-3p PRICKLE2 1.76094007417453 0.000216137556256765 -3.45141746786942 2.23819194762863e-06 MirTarget;miRNATAP -0.184798835871008 0.0366340780318301 NA NA NA hsa-miR-320b PRICKLE2 0.20205459771295 0.727216419960509 -3.45141746786942 2.23819194762863e-06 mirMAP -0.151830412827393 0.0379189867353708 NA NA NA hsa-miR-320c PRICKLE2 -0.10618808730545 0.854002814666472 -3.45141746786942 2.23819194762863e-06 mirMAP -0.192024601401586 0.010110313029993 NA NA NA hsa-miR-326 PRICKLE2 1.76645822596029 0.0367310428720192 -3.45141746786942 2.23819194762863e-06 miRanda;miRNATAP -0.112318734070594 0.0248291261444817 NA NA NA hsa-miR-330-3p PRICKLE2 2.49094236945806 0.000129367003214715 -3.45141746786942 2.23819194762863e-06 MirTarget -0.242408684206499 0.000148397852684028 NA NA NA hsa-miR-330-5p PRICKLE2 2.25110496739954 0.000275527655397415 -3.45141746786942 2.23819194762863e-06 miRanda;miRNATAP -0.304068403465464 5.24453460154095e-06 NA NA NA hsa-miR-33a-3p PRICKLE2 2.06269680799532 0.00156436055383943 -3.45141746786942 2.23819194762863e-06 mirMAP -0.169610144531884 0.00853422264620373 NA NA NA hsa-miR-33a-5p PRICKLE2 2.60046838991599 0.000472459723448608 -3.45141746786942 2.23819194762863e-06 MirTarget -0.208858942311621 0.000179412583116712 NA NA NA hsa-miR-33b-5p PRICKLE2 4.77891217497671 1.33695107675057e-08 -3.45141746786942 2.23819194762863e-06 MirTarget -0.308295499263836 9.41436315322474e-11 NA NA NA hsa-miR-3922-3p PRICKLE2 2.5745007343008 8.26367348669111e-05 -3.45141746786942 2.23819194762863e-06 MirTarget;miRNATAP -0.146278473668056 0.0255674812161562 NA NA NA hsa-miR-429 PRICKLE2 6.39965293994036 1.96920201593608e-18 -3.45141746786942 2.23819194762863e-06 miRNATAP -0.192564785179246 0.000363170475329292 NA NA NA hsa-miR-484 PRICKLE2 1.79050445056016 0.000217287101253701 -3.45141746786942 2.23819194762863e-06 miRNATAP -0.261502761906927 0.00251914112807643 NA NA NA hsa-miR-576-5p PRICKLE2 1.30320223793746 0.00648929463912994 -3.45141746786942 2.23819194762863e-06 mirMAP -0.220843550517725 0.0123035226574629 NA NA NA hsa-miR-590-3p PRICKLE2 2.35429565068338 2.79601879608564e-06 -3.45141746786942 2.23819194762863e-06 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.280024083689801 0.00069950432111314 NA NA NA hsa-miR-592 PRICKLE2 2.80403350008555 0.0293520213681333 -3.45141746786942 2.23819194762863e-06 mirMAP -0.124045316601949 0.00188888312343625 NA NA NA hsa-miR-629-3p PRICKLE2 3.48282157979573 4.9176538695908e-08 -3.45141746786942 2.23819194762863e-06 MirTarget -0.289397005386756 5.78872525645679e-06 NA NA NA hsa-miR-7-1-3p PRICKLE2 1.43074343339835 0.00471215970502094 -3.45141746786942 2.23819194762863e-06 MirTarget -0.317376129149821 0.000124131315390086 NA NA NA hsa-let-7a-3p PRKACB 0.82512001802525 0.0468122405194487 -1.46896806095161 0.00691161548744777 MirTarget;mirMAP;miRNATAP -0.212227756129949 0.00484060334729975 NA NA NA hsa-let-7f-1-3p PRKACB 1.61507869803314 0.00069342464777815 -1.46896806095161 0.00691161548744777 MirTarget;mirMAP -0.153633672665785 0.0188406734868941 NA NA NA hsa-miR-141-3p PRKACB 7.30474126597325 1.45115996357606e-24 -1.46896806095161 0.00691161548744777 MirTarget;TargetScan;miRNATAP -0.179713976485568 5.50509722074074e-06 NA NA NA hsa-miR-16-2-3p PRKACB 3.79845098071094 1.49120139344659e-13 -1.46896806095161 0.00691161548744777 mirMAP -0.256987391063205 7.64721558586313e-06 NA NA NA hsa-miR-17-5p PRKACB 2.3269271449522 2.13987445663942e-05 -1.46896806095161 0.00691161548744777 TargetScan -0.147030961972885 0.00870649595844882 NA NA NA hsa-miR-182-5p PRKACB 5.86988712704738 1.22411588571584e-15 -1.46896806095161 0.00691161548744777 MirTarget;miRNATAP -0.137741652786639 0.000572629355125557 NA NA NA hsa-miR-183-5p PRKACB 6.61903249270777 1.00958881445636e-16 -1.46896806095161 0.00691161548744777 MirTarget -0.125680903296988 0.000602029705127091 NA NA NA hsa-miR-18a-5p PRKACB 3.90770175770219 9.15298615034137e-10 -1.46896806095161 0.00691161548744777 miRNATAP -0.147626596716624 0.00172397395444837 NA NA NA hsa-miR-193a-3p PRKACB 0.646392169474854 0.207134343676122 -1.46896806095161 0.00691161548744777 miRanda -0.257394862253127 1.9252355211219e-05 NA NA NA hsa-miR-19a-3p PRKACB 2.17020503944519 0.00122084653711062 -1.46896806095161 0.00691161548744777 MirTarget;miRNATAP -0.131490327577289 0.0040920531186784 NA NA NA hsa-miR-19b-3p PRKACB 1.67581705793313 0.000858910586302716 -1.46896806095161 0.00691161548744777 miRNAWalker2_validate;MirTarget;miRNATAP -0.191193316637283 0.00183404785527112 NA NA NA hsa-miR-200a-3p PRKACB 6.336081120041 4.024313571871e-16 -1.46896806095161 0.00691161548744777 MirTarget;miRNATAP -0.104144124001908 0.00576356163422443 NA NA NA hsa-miR-200c-3p PRKACB 6.47012025883743 2.64500707716408e-26 -1.46896806095161 0.00691161548744777 MirTarget;miRNATAP -0.145130591541329 0.00181365494045828 NA NA NA hsa-miR-2110 PRKACB 1.8070969695103 0.00137196847440523 -1.46896806095161 0.00691161548744777 MirTarget -0.110796601580735 0.0478171002562626 NA NA NA hsa-miR-3065-5p PRKACB 2.14185373842821 0.0609400502269891 -1.46896806095161 0.00691161548744777 MirTarget -0.128827162641901 0.000116356569225078 NA NA NA hsa-miR-30d-3p PRKACB -0.0740421896025512 0.857423650167556 -1.46896806095161 0.00691161548744777 mirMAP -0.149931488326972 0.0496499969555609 NA NA NA hsa-miR-362-3p PRKACB 0.679952485897744 0.226148468488576 -1.46896806095161 0.00691161548744777 PITA;miRanda;miRNATAP -0.132462710993008 0.0171492521812846 NA NA NA hsa-miR-3653-3p PRKACB 2.32416512605984 0.000268136992079666 -1.46896806095161 0.00691161548744777 MirTarget -0.101834528600714 0.0351697054212881 NA NA NA hsa-miR-429 PRKACB 6.39965293994036 1.96920201593608e-18 -1.46896806095161 0.00691161548744777 MirTarget;PITA;miRanda;miRNATAP -0.108770954611392 0.00641118010678973 NA NA NA hsa-miR-590-3p PRKACB 2.35429565068338 2.79601879608564e-06 -1.46896806095161 0.00691161548744777 MirTarget;PITA;miRanda;miRNATAP -0.150489017415495 0.0136835439007164 NA NA NA hsa-miR-590-5p PRKACB 1.51400888103768 0.0023888567923017 -1.46896806095161 0.00691161548744777 miRanda -0.159509934061525 0.0102765865766552 NA NA NA hsa-miR-93-5p PRKACB 2.65964181833033 2.58315947526774e-08 -1.46896806095161 0.00691161548744777 miRNAWalker2_validate -0.1828758599464 0.00409856289818273 NA NA NA hsa-miR-96-5p PRKACB 5.62521466029286 1.54938806718028e-10 -1.46896806095161 0.00691161548744777 miRNATAP -0.17033105097326 3.99524226143001e-05 NA NA NA hsa-miR-142-5p PRKCA 3.95552531913424 1.49536283724079e-08 -2.51484065178579 0.000301846026330391 mirMAP -0.157985182568495 0.00450284307697346 NA NA NA hsa-miR-150-5p PRKCA 1.76769157530064 0.0593795975117846 -2.51484065178579 0.000301846026330391 mirMAP -0.101659975658059 0.0163901852906805 NA NA NA hsa-miR-17-3p PRKCA 1.2477858204856 0.00186593270231258 -2.51484065178579 0.000301846026330391 miRNAWalker2_validate -0.250110875476973 0.0124590231030172 NA NA NA hsa-miR-183-5p PRKCA 6.61903249270777 1.00958881445636e-16 -2.51484065178579 0.000301846026330391 miRNATAP -0.195964689338451 2.96312561009603e-05 NA NA NA hsa-miR-200c-3p PRKCA 6.47012025883743 2.64500707716408e-26 -2.51484065178579 0.000301846026330391 miRNATAP -0.227644911192639 0.000134967313056447 NA NA NA hsa-miR-27b-5p PRKCA 0.213392605793392 0.71562473353293 -2.51484065178579 0.000301846026330391 mirMAP -0.165849600817832 0.0152727550349998 NA NA NA hsa-miR-30e-3p PRKCA -0.0362193022195196 0.932577027239525 -2.51484065178579 0.000301846026330391 mirMAP -0.330264937460595 0.000431865199778726 NA NA NA hsa-miR-330-3p PRKCA 2.49094236945806 0.000129367003214715 -2.51484065178579 0.000301846026330391 mirMAP -0.173880498227238 0.0042321147753766 NA NA NA hsa-miR-340-5p PRKCA 1.41210478721579 0.00958612942879818 -2.51484065178579 0.000301846026330391 mirMAP -0.247780249808726 0.000683356782218492 NA NA NA hsa-miR-374a-3p PRKCA 0.465360399099794 0.305267458251279 -2.51484065178579 0.000301846026330391 mirMAP -0.324087022951615 0.000236966482552477 NA NA NA hsa-miR-374a-5p PRKCA 0.278549982012055 0.45888283715888 -2.51484065178579 0.000301846026330391 mirMAP -0.315860192203564 0.00334938709870334 NA NA NA hsa-miR-590-3p PRKCA 2.35429565068338 2.79601879608564e-06 -2.51484065178579 0.000301846026330391 PITA;miRanda;mirMAP;miRNATAP -0.344157378397527 9.41463074505618e-06 NA NA NA hsa-miR-9-5p PRKCA 1.79620806707734 0.14526963042518 -2.51484065178579 0.000301846026330391 miRNATAP -0.102263861653536 0.00143068318206041 NA NA NA hsa-miR-93-3p PRKCA 2.62833115374128 2.28843227834337e-07 -2.51484065178579 0.000301846026330391 mirMAP -0.1626151037279 0.0358285973339973 NA NA NA hsa-miR-944 PRKCA 7.20925181386398 0.000823207457340648 -2.51484065178579 0.000301846026330391 PITA;miRNATAP -0.163061119524878 9.18211721568101e-14 NA NA NA hsa-miR-129-5p PRKCB -2.66843722411409 0.00695783358331245 -1.37779465994896 0.125783325051528 miRanda;mirMAP -0.148528580809065 0.00435751368999719 NA NA NA hsa-miR-130a-5p PRKCB 1.58028512890005 0.024346333013728 -1.37779465994896 0.125783325051528 mirMAP -0.212100504604163 0.00409650973476373 NA NA NA hsa-miR-141-5p PRKCB 7.13744624551943 4.06877058732583e-26 -1.37779465994896 0.125783325051528 mirMAP -0.19239678572128 0.00558256661173632 NA NA NA hsa-miR-200b-3p PRKCB 5.56167217794639 6.43540045061709e-16 -1.37779465994896 0.125783325051528 MirTarget -0.301150868895001 1.67192981795653e-05 NA NA NA hsa-miR-200c-3p PRKCB 6.47012025883743 2.64500707716408e-26 -1.37779465994896 0.125783325051528 MirTarget;miRNATAP -0.348745791831867 4.59454351785762e-06 NA NA NA hsa-miR-24-3p PRKCB 1.55853749533999 0.000524726461381821 -1.37779465994896 0.125783325051528 miRNATAP -0.348466036252195 0.00216084517312112 NA NA NA hsa-miR-30b-5p PRKCB 0.0238659735605804 0.953223658270319 -1.37779465994896 0.125783325051528 mirMAP -0.253616667618375 0.0471467076624997 NA NA NA hsa-miR-30c-5p PRKCB 0.38723991118075 0.348605235643473 -1.37779465994896 0.125783325051528 mirMAP -0.252667198815732 0.04433194805965 NA NA NA hsa-miR-30d-3p PRKCB -0.0740421896025512 0.857423650167556 -1.37779465994896 0.125783325051528 mirMAP -0.466704414757516 0.000189785701017437 NA NA NA hsa-miR-335-3p PRKCB 1.19503568251824 0.0938852560631551 -1.37779465994896 0.125783325051528 mirMAP -0.319943845988664 6.21148850866805e-06 NA NA NA hsa-miR-335-5p PRKCB 0.167216045757305 0.803897055331049 -1.37779465994896 0.125783325051528 mirMAP -0.264751633170281 0.000471558920124749 NA NA NA hsa-miR-361-5p PRKCB 0.00649167180664723 0.985202350239079 -1.37779465994896 0.125783325051528 MirTarget;miRanda;miRNATAP -0.348222351488268 0.0197536719849291 NA NA NA hsa-miR-429 PRKCB 6.39965293994036 1.96920201593608e-18 -1.37779465994896 0.125783325051528 MirTarget;miRanda;miRNATAP -0.361917851736747 2.11441310702277e-08 NA NA NA hsa-miR-491-5p PRKCB 0.569358547192776 0.313310594748302 -1.37779465994896 0.125783325051528 miRanda -0.220210617720326 0.0171203204924109 NA NA NA hsa-miR-502-5p PRKCB -0.614788359240004 0.318237800399635 -1.37779465994896 0.125783325051528 mirMAP -0.19399879844192 0.0234169740840594 NA NA NA hsa-miR-589-3p PRKCB 1.33205316880069 0.052632683806148 -1.37779465994896 0.125783325051528 mirMAP -0.256370688506043 0.000574321239976677 NA NA NA hsa-miR-590-5p PRKCB 1.51400888103768 0.0023888567923017 -1.37779465994896 0.125783325051528 miRanda -0.299520538968311 0.00345339662465929 NA NA NA hsa-miR-9-3p PRKCB 1.69328215716742 0.125170982657059 -1.37779465994896 0.125783325051528 mirMAP -0.175906285304137 0.000158783736278398 NA NA NA hsa-miR-130a-5p PRKX 1.58028512890005 0.024346333013728 2.17507999383594 0.000704686070863552 mirMAP -0.187730727746443 0.00038419514315305 NA NA NA hsa-miR-148b-3p PRKX 1.75622244535669 8.84414356040579e-08 2.17507999383594 0.000704686070863552 MirTarget -0.306982570800927 0.00606517379097925 NA NA NA hsa-miR-181b-5p PRKX 1.11397227523501 0.0273417050354018 2.17507999383594 0.000704686070863552 mirMAP -0.171922484715549 0.0185944166277157 NA NA NA hsa-miR-29b-3p PRKX 0.666547117072858 0.234055379278093 2.17507999383594 0.000704686070863552 mirMAP -0.164536960121623 0.0124366136750478 NA NA NA hsa-miR-335-3p PRKX 1.19503568251824 0.0938852560631551 2.17507999383594 0.000704686070863552 mirMAP -0.162862473837577 0.00148982890472507 NA NA NA hsa-miR-186-5p PSEN1 0.445443449112564 0.185447310527704 0.368661147327623 0.170605556176267 mirMAP -0.185745049339955 4.75468410670268e-05 NA NA NA hsa-miR-374a-5p RAC1 0.278549982012055 0.45888283715888 0.0440982372971011 0.900045954349393 mirMAP -0.140356402054542 0.00882655342567711 NA NA NA hsa-miR-423-3p RAC1 1.7128674316395 1.7145324528301e-05 0.0440982372971011 0.900045954349393 PITA -0.102556930065336 0.0395525557948466 NA NA NA hsa-miR-450b-5p RAC1 0.445103105471153 0.416021465008949 0.0440982372971011 0.900045954349393 mirMAP -0.108599310907085 0.00278942668689792 NA NA NA hsa-miR-129-5p RAC2 -2.66843722411409 0.00695783358331245 1.63571810371488 0.0215946836435966 miRanda -0.123304880787715 0.00280670600839041 NA NA NA hsa-miR-342-3p RAC3 1.31107714473009 0.0207211910724662 3.52496172007521 1.4204597965252e-06 miRanda -0.189447751710799 0.0110218885344486 NA NA NA hsa-miR-664a-3p ROCK1 0.249882351950296 0.56171157318348 -0.508459228982796 0.157162538507041 mirMAP -0.102372137778216 0.0323715103346566 NA NA NA hsa-let-7a-3p ROCK2 0.82512001802525 0.0468122405194487 -0.982794429557542 0.144534846884159 mirMAP -0.287135080994927 0.00198598698276818 NA NA NA hsa-miR-142-3p ROCK2 4.35304505457969 3.10014573651358e-10 -0.982794429557542 0.144534846884159 PITA;miRanda;miRNATAP -0.159877164823284 0.00282210588614417 NA NA NA hsa-miR-142-5p ROCK2 3.95552531913424 1.49536283724079e-08 -0.982794429557542 0.144534846884159 PITA -0.117236282243549 0.028405742008836 NA NA NA hsa-miR-224-3p ROCK2 2.84876340814503 0.000179138399939161 -0.982794429557542 0.144534846884159 mirMAP -0.138248944552857 0.00579163824403207 NA NA NA hsa-miR-3607-3p ROCK2 1.38015131722213 0.0240067155694847 -0.982794429557542 0.144534846884159 mirMAP -0.228150377670738 0.000240782728860781 NA NA NA hsa-miR-590-3p ROCK2 2.35429565068338 2.79601879608564e-06 -0.982794429557542 0.144534846884159 miRanda;mirMAP -0.284800877986152 0.000141234831462107 NA NA NA hsa-miR-144-3p SFRP1 2.05914250670468 0.0977571657256429 -4.05099494825295 0.00788885256174047 MirTarget;miRNATAP -0.163371606903926 0.0196074586295648 NA NA NA hsa-miR-16-1-3p SFRP1 2.83281226969693 7.54359864580834e-09 -4.05099494825295 0.00788885256174047 MirTarget -0.549041537326192 0.00156963680356568 NA NA NA hsa-miR-182-5p SFRP1 5.86988712704738 1.22411588571584e-15 -4.05099494825295 0.00788885256174047 mirMAP -0.37114475228972 0.000961641414082013 NA NA NA hsa-miR-19b-1-5p SFRP1 1.51335451095424 0.0014717605268143 -4.05099494825295 0.00788885256174047 MirTarget -0.505630617444352 0.00568002812072431 NA NA NA hsa-miR-203a-3p SFRP1 6.35084246337388 7.89944323347948e-08 -4.05099494825295 0.00788885256174047 MirTarget -0.346403144409134 9.53807015666787e-07 NA NA NA hsa-miR-26b-3p SFRP1 0.985177548213122 0.0351427970185971 -4.05099494825295 0.00788885256174047 MirTarget -0.466192429468718 0.012772616731021 NA NA NA hsa-miR-33a-3p SFRP1 2.06269680799532 0.00156436055383943 -4.05099494825295 0.00788885256174047 MirTarget -0.687662787724045 1.5419508092046e-07 NA NA NA hsa-miR-429 SFRP1 6.39965293994036 1.96920201593608e-18 -4.05099494825295 0.00788885256174047 miRNATAP -0.634291762958993 7.50057649683851e-09 NA NA NA hsa-miR-484 SFRP1 1.79050445056016 0.000217287101253701 -4.05099494825295 0.00788885256174047 MirTarget -0.412335859790362 0.0215530250724497 NA NA NA hsa-miR-486-5p SFRP1 1.10898145177457 0.309287974401609 -4.05099494825295 0.00788885256174047 MirTarget;miRanda -0.195243664155498 0.0141068660017734 NA NA NA hsa-miR-501-5p SFRP1 1.0411896821345 0.0777206709183552 -4.05099494825295 0.00788885256174047 mirMAP -0.396225021182035 0.00725128386303335 NA NA NA hsa-miR-940 SFRP1 3.78496690968119 4.75227557809023e-05 -4.05099494825295 0.00788885256174047 MirTarget -0.304584104323152 0.00701763875280759 NA NA NA hsa-miR-96-5p SFRP1 5.62521466029286 1.54938806718028e-10 -4.05099494825295 0.00788885256174047 mirMAP -0.392815384619956 0.000786676354596085 NA NA NA hsa-miR-582-5p SFRP2 0.685177900016753 0.447761540297692 1.32453723410308 0.331501794222753 miRNATAP -0.242546911407179 0.00458427423019383 NA NA NA hsa-miR-135b-5p SFRP4 4.81084743274382 5.89180530843625e-08 -5.17574172449817 0.00555408538544092 MirTarget -0.282620332182616 0.0161144460983879 NA NA NA hsa-miR-144-5p SFRP4 1.01673279814999 0.403344913421629 -5.17574172449817 0.00555408538544092 MirTarget -0.359839289193151 3.20171457086971e-05 NA NA NA hsa-miR-429 SFRP4 6.39965293994036 1.96920201593608e-18 -5.17574172449817 0.00555408538544092 miRanda -0.271092751012932 0.0489407103525152 NA NA NA hsa-miR-374b-5p SMAD2 -0.114749866169918 0.764888930049438 0.04613352062659 0.893023563998003 MirTarget -0.129583837300731 0.0115512001155785 NA NA NA hsa-let-7g-3p SMAD3 2.09736290930341 5.30067796437833e-05 0.160014583572917 0.778517282766047 mirMAP -0.257984897034794 2.44423650375142e-05 NA NA NA hsa-miR-17-5p SMAD3 2.3269271449522 2.13987445663942e-05 0.160014583572917 0.778517282766047 miRNAWalker2_validate -0.165009353618131 0.00461261808419179 NA NA NA hsa-miR-186-5p SMAD3 0.445443449112564 0.185447310527704 0.160014583572917 0.778517282766047 mirMAP -0.742764319550064 2.12349457043014e-15 NA NA NA hsa-miR-188-5p SMAD3 1.39111178824125 0.0251592818948912 0.160014583572917 0.778517282766047 PITA -0.238758119317103 3.46346507109757e-06 NA NA NA hsa-miR-20a-3p SMAD3 1.9920766549842 0.000624458530894697 0.160014583572917 0.778517282766047 MirTarget -0.113586093609298 0.0394412989574893 NA NA NA hsa-miR-28-5p SMAD3 -0.815636722979196 0.0221199948901761 0.160014583572917 0.778517282766047 miRNATAP -0.238288702750939 0.00948140473131226 NA NA NA hsa-miR-29b-2-5p SMAD3 -0.596051745078872 0.189540844841389 0.160014583572917 0.778517282766047 mirMAP -0.33018047859631 3.00181288669247e-06 NA NA NA hsa-miR-30a-3p SMAD3 -1.22212086897848 0.167565797592104 0.160014583572917 0.778517282766047 mirMAP -0.125743455849957 0.000500972339732145 NA NA NA hsa-miR-30d-3p SMAD3 -0.0740421896025512 0.857423650167556 0.160014583572917 0.778517282766047 mirMAP -0.265215856067837 0.000784444342632096 NA NA NA hsa-miR-32-3p SMAD3 2.20477794939766 0.0392771274032852 0.160014583572917 0.778517282766047 mirMAP -0.139443193805526 0.00854369021916498 NA NA NA hsa-miR-335-3p SMAD3 1.19503568251824 0.0938852560631551 0.160014583572917 0.778517282766047 mirMAP -0.150203529209219 0.000833797912476475 NA NA NA hsa-miR-335-5p SMAD3 0.167216045757305 0.803897055331049 0.160014583572917 0.778517282766047 miRNAWalker2_validate -0.170051000133026 0.000363968836124472 NA NA NA hsa-miR-345-5p SMAD3 2.77314563304336 4.34343702412489e-05 0.160014583572917 0.778517282766047 mirMAP -0.193422457386819 3.24971867546412e-05 NA NA NA hsa-miR-501-5p SMAD3 1.0411896821345 0.0777206709183552 0.160014583572917 0.778517282766047 mirMAP -0.280514332977103 1.82290826802372e-07 NA NA NA hsa-miR-576-5p SMAD3 1.30320223793746 0.00648929463912994 0.160014583572917 0.778517282766047 mirMAP -0.143556531357487 0.0337207679032995 NA NA NA hsa-miR-589-3p SMAD3 1.33205316880069 0.052632683806148 0.160014583572917 0.778517282766047 mirMAP -0.202014876353946 1.49389042617214e-05 NA NA NA hsa-miR-616-5p SMAD3 2.48416313933027 0.00318247475868827 0.160014583572917 0.778517282766047 mirMAP -0.241397292057418 2.69938790277874e-07 NA NA NA hsa-miR-671-5p SMAD3 1.48527046124636 0.00686722328347111 0.160014583572917 0.778517282766047 MirTarget -0.193412590030654 0.000928749665735432 NA NA NA hsa-miR-7-1-3p SMAD3 1.43074343339835 0.00471215970502094 0.160014583572917 0.778517282766047 mirMAP -0.168365832898427 0.00819700709319524 NA NA NA hsa-miR-769-5p SMAD3 0.41777775802937 0.343089124193569 0.160014583572917 0.778517282766047 miRNATAP -0.366412732630904 4.82674495052425e-07 NA NA NA hsa-miR-21-3p SMAD4 3.50297439576639 6.39946844099206e-10 -1.1222647897474 0.00638923144286853 mirMAP -0.112729088104479 0.00502861854832022 NA NA NA hsa-miR-27a-3p SMAD4 1.76094007417453 0.000216137556256765 -1.1222647897474 0.00638923144286853 MirTarget -0.132335336531126 0.00695151522053189 NA NA NA hsa-miR-32-5p SMAD4 2.93035124381469 5.00149131394151e-10 -1.1222647897474 0.00638923144286853 mirMAP -0.119614186597926 0.0138442807407647 NA NA NA hsa-miR-590-3p SMAD4 2.35429565068338 2.79601879608564e-06 -1.1222647897474 0.00638923144286853 MirTarget;PITA;miRanda;miRNATAP -0.108763251915953 0.0183914722302907 NA NA NA hsa-miR-141-3p SOX17 7.30474126597325 1.45115996357606e-24 -4.63134297267781 0.000312264433803198 TargetScan -0.195526013687543 0.0401728968617868 22921431 Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer; MicroRNA 141 was also found to down-regulate SOX17 expression and activate the WNT signal pathway esophageal cancer hsa-miR-330-5p SOX17 2.25110496739954 0.000275527655397415 -4.63134297267781 0.000312264433803198 miRanda -0.471495211507339 5.74811025406178e-05 NA NA NA hsa-miR-142-3p TBL1X 4.35304505457969 3.10014573651358e-10 -2.18091245523924 4.00427713003879e-05 MirTarget;PITA;miRanda;miRNATAP -0.164381176345582 0.00010822877011412 NA NA NA hsa-miR-22-5p TBL1X 2.38337850108621 1.0773503998394e-05 -2.18091245523924 4.00427713003879e-05 mirMAP -0.138217221512771 0.0131476882336703 NA NA NA hsa-miR-484 TBL1X 1.79050445056016 0.000217287101253701 -2.18091245523924 4.00427713003879e-05 PITA -0.231411278192992 0.000209247258351217 NA NA NA hsa-miR-181a-5p TBL1XR1 1.25558293560636 0.00748975499703878 0.860959882206589 0.0161483647891579 mirMAP -0.127758983298776 0.00318260973301241 NA NA NA hsa-miR-181c-5p TBL1XR1 -0.302833440762172 0.537532549455539 0.860959882206589 0.0161483647891579 MirTarget;mirMAP -0.121585763845284 0.00346013270504262 NA NA NA hsa-miR-142-5p TCF7L1 3.95552531913424 1.49536283724079e-08 -2.01358509693913 0.0134449848880761 PITA -0.212267103740507 0.00102071148741226 NA NA NA hsa-miR-200a-3p TCF7L1 6.336081120041 4.024313571871e-16 -2.01358509693913 0.0134449848880761 miRNAWalker2_validate -0.203461925521664 0.000299485175056615 NA NA NA hsa-miR-200b-3p TCF7L1 5.56167217794639 6.43540045061709e-16 -2.01358509693913 0.0134449848880761 miRNAWalker2_validate -0.213878073046112 0.000814272240549089 NA NA NA hsa-miR-429 TCF7L1 6.39965293994036 1.96920201593608e-18 -2.01358509693913 0.0134449848880761 miRNAWalker2_validate -0.145244347363154 0.0152558300773621 NA NA NA hsa-miR-155-5p TCF7L2 2.81443182173772 7.42530504828797e-05 -1.23546095022525 0.000440438934902147 MirTarget;miRNATAP -0.104046086417659 0.000174591712156132 NA NA NA hsa-miR-193a-3p TCF7L2 0.646392169474854 0.207134343676122 -1.23546095022525 0.000440438934902147 miRanda -0.157722671038068 5.3142399209646e-05 NA NA NA hsa-miR-942-5p TCF7L2 3.36242661558642 1.89848306955335e-10 -1.23546095022525 0.000440438934902147 MirTarget -0.146878706302034 6.24208059630175e-05 NA NA NA hsa-miR-148a-3p VANGL1 1.1031350648218 0.052038169812979 1.13984796839351 0.000569278893221097 mirMAP -0.126007552197972 0.000135485224544635 NA NA NA hsa-miR-26a-5p VANGL1 -0.352368463397074 0.362040749917446 1.13984796839351 0.000569278893221097 mirMAP -0.163235502722612 0.000936038031106047 NA NA NA hsa-miR-26b-5p VANGL1 0.314414148564179 0.461628303578321 1.13984796839351 0.000569278893221097 miRNAWalker2_validate;mirMAP -0.110475741813127 0.0133704144525921 NA NA NA hsa-miR-29a-5p VANGL1 0.0748295222568571 0.884125894063293 1.13984796839351 0.000569278893221097 mirMAP -0.100073965894972 0.00672264355888395 NA NA NA hsa-miR-374a-3p VANGL1 0.465360399099794 0.305267458251279 1.13984796839351 0.000569278893221097 mirMAP -0.129036105786491 0.00202204519960015 NA NA NA hsa-miR-590-3p VANGL1 2.35429565068338 2.79601879608564e-06 1.13984796839351 0.000569278893221097 miRanda -0.107912071602501 0.00358015608999926 NA NA NA hsa-let-7g-3p VANGL2 2.09736290930341 5.30067796437833e-05 0.992854229029871 0.242960635033609 miRNATAP -0.210702391948593 0.022760095068357 NA NA NA hsa-miR-106a-5p VANGL2 3.98693608217557 9.37722470816656e-07 0.992854229029871 0.242960635033609 mirMAP -0.13014444125885 0.0255829902890413 NA NA NA hsa-miR-186-5p VANGL2 0.445443449112564 0.185447310527704 0.992854229029871 0.242960635033609 mirMAP -0.39410517411477 0.00719264293797182 NA NA NA hsa-miR-30a-5p VANGL2 -0.768430903969183 0.320487552854215 0.992854229029871 0.242960635033609 mirMAP -0.238856634940204 0.000115346457577537 NA NA NA hsa-miR-335-5p VANGL2 0.167216045757305 0.803897055331049 0.992854229029871 0.242960635033609 miRNAWalker2_validate -0.183857525730483 0.0104570349724712 NA NA NA hsa-miR-362-5p VANGL2 -1.22309034685697 0.0452665543907975 0.992854229029871 0.242960635033609 mirMAP -0.15947710480432 0.0440235373456105 NA NA NA hsa-miR-582-3p VANGL2 0.280903327757368 0.772626550200977 0.992854229029871 0.242960635033609 mirMAP -0.152108361860204 0.00209454847984174 NA NA NA hsa-miR-582-5p VANGL2 0.685177900016753 0.447761540297692 0.992854229029871 0.242960635033609 PITA;miRNATAP -0.175470012023391 0.000973319706525932 NA NA NA hsa-miR-589-3p VANGL2 1.33205316880069 0.052632683806148 0.992854229029871 0.242960635033609 mirMAP -0.203355021483621 0.00391238641397579 NA NA NA hsa-miR-589-5p VANGL2 1.55790780760302 0.000326340665093671 0.992854229029871 0.242960635033609 mirMAP -0.326311110039648 0.00337063244243347 NA NA NA hsa-miR-96-5p VANGL2 5.62521466029286 1.54938806718028e-10 0.992854229029871 0.242960635033609 TargetScan -0.180079366190349 0.00566800729841227 NA NA NA hsa-miR-330-3p WIF1 2.49094236945806 0.000129367003214715 -3.0008918844809 0.103713979441329 PITA;miRNATAP -0.468999434893068 0.00335514436899957 NA NA NA hsa-miR-330-5p WIF1 2.25110496739954 0.000275527655397415 -3.0008918844809 0.103713979441329 miRanda -0.595586503986047 0.000372749451536107 NA NA NA hsa-miR-342-3p WIF1 1.31107714473009 0.0207211910724662 -3.0008918844809 0.103713979441329 miRanda -0.646060279165219 0.000454416850868616 NA NA NA hsa-miR-664a-3p WNT10A 0.249882351950296 0.56171157318348 4.50187444135611 0.000590394273747734 mirMAP -0.487836890480239 0.00563420427073706 NA NA NA hsa-miR-335-5p WNT10B 0.167216045757305 0.803897055331049 1.33140247707668 0.178289436708634 miRNAWalker2_validate -0.17848030267788 0.0330165036447929 NA NA NA hsa-miR-590-3p WNT11 2.35429565068338 2.79601879608564e-06 -1.12002304030541 0.399603501707316 miRanda -0.529097966959972 0.000347687911762461 NA NA NA hsa-miR-146b-3p WNT16 1.34608871980101 0.00935728391852709 0.34788001398837 0.748349917696045 MirTarget -0.37742443073334 0.00145623124068643 NA NA NA hsa-miR-338-3p WNT16 0.447551118940466 0.558485097370031 0.34788001398837 0.748349917696045 miRanda -0.226165128589222 0.00487183921721476 NA NA NA hsa-miR-339-5p WNT16 1.23326828594484 0.0307501214818698 0.34788001398837 0.748349917696045 miRanda -0.331104236072021 0.00208818597534857 NA NA NA hsa-miR-590-3p WNT16 2.35429565068338 2.79601879608564e-06 0.34788001398837 0.748349917696045 PITA;miRanda;mirMAP -0.294631191207902 0.0150787691372878 NA NA NA hsa-miR-629-3p WNT16 3.48282157979573 4.9176538695908e-08 0.34788001398837 0.748349917696045 MirTarget -0.209045931363057 0.0268476228439377 NA NA NA hsa-let-7f-2-3p WNT2 1.02768112108475 0.0787293499732611 -3.299390730363 0.00348976107203057 MirTarget -0.299782609265936 0.00806308209760041 NA NA NA hsa-miR-324-5p WNT2 1.31253452379847 0.0116806680545163 -3.299390730363 0.00348976107203057 miRanda -0.36189140777637 0.00350229441341699 NA NA NA hsa-miR-335-3p WNT2 1.19503568251824 0.0938852560631551 -3.299390730363 0.00348976107203057 mirMAP -0.35269768882803 8.41491455046423e-05 NA NA NA hsa-miR-590-3p WNT2 2.35429565068338 2.79601879608564e-06 -3.299390730363 0.00348976107203057 miRanda;mirMAP -0.297855630348575 0.019190931811268 NA NA NA hsa-miR-944 WNT2 7.20925181386398 0.000823207457340648 -3.299390730363 0.00348976107203057 mirMAP -0.146635065441429 6.02984984638211e-05 NA NA NA hsa-miR-125a-3p WNT2B -0.0748960586927341 0.920735897434087 -0.856171452484765 0.502995562863325 miRanda -0.504617595226248 1.05618585936844e-07 NA NA NA hsa-miR-130a-3p WNT2B 0.176861046122832 0.7577473016872 -0.856171452484765 0.502995562863325 MirTarget -0.282182222509113 0.0266005542225914 NA NA NA hsa-miR-186-5p WNT2B 0.445443449112564 0.185447310527704 -0.856171452484765 0.502995562863325 mirMAP -0.83839518234891 0.000129537010945903 NA NA NA hsa-miR-301a-3p WNT2B 1.99338115332667 0.000813358604963724 -0.856171452484765 0.502995562863325 MirTarget -0.342895282405635 0.00462467447879055 NA NA NA hsa-miR-32-3p WNT2B 2.20477794939766 0.0392771274032852 -0.856171452484765 0.502995562863325 mirMAP -0.274939865308761 0.0214409862658441 NA NA NA hsa-miR-454-3p WNT2B 1.40269869979902 0.00366085847011367 -0.856171452484765 0.502995562863325 MirTarget -0.374085329266783 0.0129944108806478 NA NA NA hsa-miR-616-5p WNT2B 2.48416313933027 0.00318247475868827 -0.856171452484765 0.502995562863325 mirMAP -0.509721719846027 1.50040236285173e-06 NA NA NA hsa-miR-126-5p WNT3 -0.420466581381807 0.329972801718418 3.00467776067193 0.00323304601055451 MirTarget -0.326437486810699 0.0169200983660217 NA NA NA hsa-miR-192-5p WNT3 1.77716187978541 0.113485496183047 3.00467776067193 0.00323304601055451 miRNAWalker2_validate -0.152954353312327 0.00301888019712671 NA NA NA hsa-miR-215-5p WNT3 3.66990923176752 0.00294614570694381 3.00467776067193 0.00323304601055451 miRNAWalker2_validate -0.103054636860125 0.0279449415950673 NA NA NA hsa-miR-107 WNT4 1.49443409571439 0.000130594521065411 0.346156151965651 0.759005168873886 PITA;miRNATAP -0.706595074754511 1.43378256348642e-05 NA NA NA hsa-miR-130a-5p WNT5A 1.58028512890005 0.024346333013728 -0.335254267155151 0.714960765245992 mirMAP -0.186740670212873 0.0132162689910119 NA NA NA hsa-miR-141-3p WNT5A 7.30474126597325 1.45115996357606e-24 -0.335254267155151 0.714960765245992 TargetScan -0.185678372077036 0.00570301174175726 NA NA NA hsa-miR-141-5p WNT5A 7.13744624551943 4.06877058732583e-26 -0.335254267155151 0.714960765245992 MirTarget;miRNATAP -0.162845388838272 0.0214954040323516 NA NA NA hsa-miR-155-5p WNT5A 2.81443182173772 7.42530504828797e-05 -0.335254267155151 0.714960765245992 miRNAWalker2_validate;mirMAP -0.174042635603077 0.0163824650362829 NA NA NA hsa-miR-15b-3p WNT5A 3.57530146629867 5.89922785773482e-11 -0.335254267155151 0.714960765245992 mirMAP -0.24311589972858 0.00863820879774156 NA NA NA hsa-miR-16-2-3p WNT5A 3.79845098071094 1.49120139344659e-13 -0.335254267155151 0.714960765245992 MirTarget;mirMAP -0.311764225567874 0.00135279684345927 NA NA NA hsa-miR-16-5p WNT5A 2.93575808220754 2.15436817162977e-10 -0.335254267155151 0.714960765245992 miRNAWalker2_validate -0.290441753916783 0.00829455186858816 NA NA NA hsa-miR-186-5p WNT5A 0.445443449112564 0.185447310527704 -0.335254267155151 0.714960765245992 miRNAWalker2_validate;mirMAP;miRNATAP -0.320286686856717 0.043394091075825 NA NA NA hsa-miR-2110 WNT5A 1.8070969695103 0.00137196847440523 -0.335254267155151 0.714960765245992 MirTarget -0.30255767867938 0.00122728628679992 NA NA NA hsa-miR-3065-5p WNT5A 2.14185373842821 0.0609400502269891 -0.335254267155151 0.714960765245992 mirMAP -0.13133554416603 0.020361826970486 NA NA NA hsa-miR-30c-5p WNT5A 0.38723991118075 0.348605235643473 -0.335254267155151 0.714960765245992 mirMAP -0.369350346658232 0.00376556464462393 NA NA NA hsa-miR-30d-3p WNT5A -0.0740421896025512 0.857423650167556 -0.335254267155151 0.714960765245992 mirMAP -0.440328526023165 0.000555223243909098 NA NA NA hsa-miR-30d-5p WNT5A 0.302504510257496 0.380193536606962 -0.335254267155151 0.714960765245992 mirMAP -0.416582436731857 0.00691722632235903 NA NA NA hsa-miR-30e-5p WNT5A 0.780047227271616 0.0346714425913016 -0.335254267155151 0.714960765245992 mirMAP -0.392965061384389 0.00598951520393619 NA NA NA hsa-miR-330-5p WNT5A 2.25110496739954 0.000275527655397415 -0.335254267155151 0.714960765245992 miRanda -0.317182601686914 0.00013146381356929 NA NA NA hsa-miR-576-5p WNT5A 1.30320223793746 0.00648929463912994 -0.335254267155151 0.714960765245992 mirMAP -0.260138025987152 0.0171378595527101 NA NA NA hsa-miR-582-5p WNT5A 0.685177900016753 0.447761540297692 -0.335254267155151 0.714960765245992 miRNATAP -0.175734719122522 0.00222477334080145 NA NA NA hsa-miR-616-5p WNT5A 2.48416313933027 0.00318247475868827 -0.335254267155151 0.714960765245992 mirMAP -0.276707442691596 0.000306684343847227 NA NA NA hsa-miR-92a-3p WNT5A 1.87892405805529 1.27013821556583e-05 -0.335254267155151 0.714960765245992 miRNAWalker2_validate -0.492024474546178 3.85220646721685e-05 NA NA NA hsa-miR-185-5p WNT5B 2.46768243458192 6.53179875424217e-08 -1.38612744018266 0.210328863913734 miRNAWalker2_validate -0.268561533721117 0.0483934778957728 NA NA NA hsa-miR-103a-3p WNT7A 0.990919087251708 0.00468308601422847 1.99490211423871 0.283859716193086 MirTarget -1.32781551331516 1.1801181900249e-05 NA NA NA hsa-miR-107 WNT7A 1.49443409571439 0.000130594521065411 1.99490211423871 0.283859716193086 MirTarget;miRanda -0.773176469447409 0.00437990373456198 NA NA NA hsa-miR-15b-5p WNT7A 3.32329949959268 8.40210501034588e-13 1.99490211423871 0.283859716193086 MirTarget -0.65869802593554 0.00275936276249016 27195958 WNT7A Regulation by miR 15b in Ovarian Cancer; In the present study we report that WNT7A is a direct target of miR-15b in ovarian cancer; We showed that a luciferase reporter containing the putative binding site of miR-15b in the WNT7A 3'-UTR was significantly repressed by miR-15b; Mutation of the putative binding site of miR-15b in the WNT7A 3'-UTR restored luciferase activity; Furthermore miR-15b was able to repress increased levels of TOPFLASH activity by WNT7A but not those induced by S33Y; Additionally miR-15b dose-dependently decreased WNT7A expression; When we evaluated the prognostic impact of WNT7A and miR-15b expression using TCGA datasets a significant inverse correlation in which high-expression of WNT7A and low-expression of miR-15b was associated with reduced survival rates of ovarian cancer patients; These results suggest that WNT7A is post-transcriptionally regulated by miR-15b which could be down-regulated by promoter hypermethylation potentially via DNMT1 in ovarian cancer poor survival ovarian cancer hsa-miR-361-5p WNT7A 0.00649167180664723 0.985202350239079 1.99490211423871 0.283859716193086 MirTarget;PITA;miRanda -1.43618972738794 2.43966057288788e-06 NA NA NA hsa-miR-374a-3p WNT7A 0.465360399099794 0.305267458251279 1.99490211423871 0.283859716193086 MirTarget -0.522398179589967 0.0265275328630484 NA NA NA hsa-miR-592 WNT7A 2.80403350008555 0.0293520213681333 1.99490211423871 0.283859716193086 mirMAP -0.379438925337118 0.000144596464812367 NA NA NA hsa-miR-10a-5p WNT7B -0.482300926520507 0.594608783320466 6.45833028681074 1.2743062072308e-11 mirMAP -0.22213369773385 0.000303981788598836 NA NA NA hsa-miR-10b-5p WNT7B -3.08172917642729 4.22675074435126e-09 6.45833028681074 1.2743062072308e-11 mirMAP -0.465142626600515 7.06702462289464e-06 NA NA NA hsa-miR-335-5p WNT7B 0.167216045757305 0.803897055331049 6.45833028681074 1.2743062072308e-11 miRNAWalker2_validate -0.210087476691105 0.0118670881269717 NA NA NA hsa-miR-491-5p WNT7B 0.569358547192776 0.313310594748302 6.45833028681074 1.2743062072308e-11 mirMAP -0.330184477241142 0.00107310673487806 NA NA NA hsa-miR-502-5p WNT7B -0.614788359240004 0.318237800399635 6.45833028681074 1.2743062072308e-11 miRNATAP -0.201052880617046 0.0324009471650832 NA NA NA hsa-miR-505-3p WNT7B 0.58881333170866 0.226937454637888 6.45833028681074 1.2743062072308e-11 miRNATAP -0.344371689601171 0.00293288321292057 NA NA NA hsa-miR-940 WNT7B 3.78496690968119 4.75227557809023e-05 6.45833028681074 1.2743062072308e-11 mirMAP -0.155593323007804 0.0331093918714337 NA NA NA hsa-miR-148a-3p WNT9A 1.1031350648218 0.052038169812979 -1.18407404695739 0.266101963440536 mirMAP -0.432898371967406 4.26603455945752e-05 NA NA NA hsa-miR-148b-3p WNT9A 1.75622244535669 8.84414356040579e-08 -1.18407404695739 0.266101963440536 mirMAP -0.87883765663712 1.34304427585441e-06 NA NA NA hsa-miR-32-5p WNT9A 2.93035124381469 5.00149131394151e-10 -1.18407404695739 0.266101963440536 mirMAP -0.363977517670086 0.00367377284132333 NA NA NA hsa-miR-331-3p WNT9A 2.60769294751513 3.84318952029483e-07 -1.18407404695739 0.266101963440536 mirMAP -0.356933157833057 0.00205063036870332 NA NA NA hsa-miR-335-5p WNT9A 0.167216045757305 0.803897055331049 -1.18407404695739 0.266101963440536 miRNAWalker2_validate -0.317725285709137 0.000385124583476028 NA NA NA hsa-miR-532-3p WNT9A 0.643755490841218 0.214842585969913 -1.18407404695739 0.266101963440536 mirMAP -0.274529895252504 0.0191874943098709 NA NA NA hsa-miR-589-3p WNT9A 1.33205316880069 0.052632683806148 -1.18407404695739 0.266101963440536 mirMAP -0.360413992507261 3.93582105522619e-05 NA NA NA hsa-miR-96-5p WNT9A 5.62521466029286 1.54938806718028e-10 -1.18407404695739 0.266101963440536 mirMAP -0.234533115491296 0.00400004958215225 NA NA NA