miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-106a-5p	AR	-0.464229535269236	0.009724944358047	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.482632128924551	1.71653223136325e-05		NA	NA	NA
hsa-miR-106b-5p	AR	0.648901865047099	8.24870862047885e-09	-2.65514434874701	6.79656050811819e-11	mirMAP	-1.42360253386613	1.3931776862992e-16		NA	NA	NA
hsa-miR-125a-3p	AR	-0.841683158494395	3.51202687176603e-05	-2.65514434874701	6.79656050811819e-11	miRNATAP	-0.507518378174808	4.15673303742784e-07		NA	NA	NA
hsa-miR-132-3p	AR	0.323796239695997	0.00272093067935091	-2.65514434874701	6.79656050811819e-11	mirMAP	-1.02664692740533	3.6724731555719e-08		NA	NA	NA
hsa-miR-136-3p	AR	-1.36517775320732	1.76511812995153e-06	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.145111502170737	0.0390163962796537		NA	NA	NA
hsa-miR-136-5p	AR	-1.19235933727542	1.43089181604509e-05	-2.65514434874701	6.79656050811819e-11	miRNATAP	-0.167821835752808	0.0221011532574674		NA	NA	NA
hsa-miR-141-3p	AR	-0.354316381352484	0.256996894288799	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.414738704972838	8.40087125475703e-11	26062412;22314666	miR 141 3p regulates the expression of androgen receptor by targeting its 3'UTR in prostate cancer LNCaP cells; After prostate cancer cell line LNCaP was transfected with miR-141-3p mimics expression levels of AR mRNA and protein in the LNCaP cells were detected by reverse transcription PCR and Western blotting respectively; The 3'untranslated regions 3'UTR of AR mRNA containing the binding site of miR-141-3p was amplified by PCR and inserted into pmiR-report vector a 3'downstream luciferase reporter gene; Transfection of miR-141-3p mimics decreased both mRNA and protein expression levels of AR in LNCaP cells; AR is a direct target gene of miR-141-3p;miR 141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein; Here we investigated the correlation of Shp expression with the cellular level of miR-141 and its effects on AR transcriptional activity in non-malignant and malignant human prostate epithelial cell lines; Phenethyl isothiocyanate a natural constituent of many edible cruciferous vegetables increased Shp expression downregulated miR-141 and inhibited AR transcriptional activity in LNCaP cells; Shp is a target for miR-141 and it is downregulated in cultured human PCa cells with the involvement of upregulation of miR-141 which promotes AR transcriptional activity	;malignant trasformation	prostate cancer;prostate cancer
hsa-miR-146a-5p	AR	-0.742958238440575	0.000765983177482633	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.423161029738674	3.10662522706658e-06	25123132	To study the cellular response to miR-146a upregulation in p53-impaired basal-like lines antagomir KD of miR-146a was performed; KD of miR-146a caused decreased proliferation and increased apoptosis effectively ablating the effects of p53 loss	drug resistance	breast cancer
hsa-miR-148b-3p	AR	0.266862251671911	0.00185271302045935	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.986871842355658	3.47058980072558e-05		NA	NA	NA
hsa-miR-148b-5p	AR	0.295777213389605	0.0255749859535438	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.820628837076767	6.85000297831131e-08		NA	NA	NA
hsa-miR-149-5p	AR	-0.317176971910036	0.187207559733877	-2.65514434874701	6.79656050811819e-11	miRNATAP	-0.351014734526115	3.21710832349419e-05		NA	NA	NA
hsa-miR-155-5p	AR	0.0108524225071784	0.95651331033505	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.468989744150432	3.77409172012017e-06		NA	NA	NA
hsa-miR-17-5p	AR	0.698861147045461	2.43854106455398e-05	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.930068942186295	3.11675184512445e-15	23095762	miR 17 5p targets the p300/CBP associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells; Targeting of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells; Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells		prostate cancer
hsa-miR-181a-5p	AR	0.250113435902954	0.0551933249319293	-2.65514434874701	6.79656050811819e-11	miRNATAP	-1.22886594580632	4.1868974504783e-16		NA	NA	NA
hsa-miR-181b-5p	AR	0.488256489401108	0.00105321129419701	-2.65514434874701	6.79656050811819e-11	miRNATAP	-1.29824857260422	6.54962591623091e-24		NA	NA	NA
hsa-miR-181c-5p	AR	-0.00639394152050299	0.969127212255928	-2.65514434874701	6.79656050811819e-11	miRNATAP	-0.776769608728083	1.34738770976139e-10		NA	NA	NA
hsa-miR-185-5p	AR	0.480006257154717	6.35758891340152e-07	-2.65514434874701	6.79656050811819e-11	miRNAWalker2_validate;MirTarget	-0.560383564223288	0.00776305882024525	25673182;26940039;23417242	MicroRNA 185 downregulates androgen receptor expression in the LNCaP prostate carcinoma cell line;MMTV-Fluc reporter assays revealed that miR-185 can attenuate AR function by suppressing BRD8 ISO2;MicroRNA 185 suppresses proliferation invasion migration and tumorigenicity of human prostate cancer cells through targeting androgen receptor; Targets prediction revealed that AR had putative complementary sequences to miR-185 which was confirmed by the following dual luciferase reporter assay; Overexpression of miR-185 could reduce the expression of AR protein but not mRNA in LNCaP cells; CDC6 one target of AR and an important regulatory molecule for cell cycle was found to be down-regulated by overexpression of miR-185; Our findings suggest that miR-185 could function as a tumor-suppressor gene in CaP by directly targeting AR and act as a potential therapeutic target for CaP	;;	prostate cancer;prostate cancer;prostate cancer
hsa-miR-19a-3p	AR	1.01712596153672	2.57753201450625e-07	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.601022995339461	1.70425289628883e-09		NA	NA	NA
hsa-miR-19b-3p	AR	0.601279551368824	0.00016685097085251	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.682837043449393	4.61947892618391e-08		NA	NA	NA
hsa-miR-200a-3p	AR	-1.49949292595657	3.18410995256133e-05	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.321533468156768	5.38246996455316e-09	24391862	We identified miR-200 b as a downstream target of androgen receptor and linked its expression to decreased tumorigenicity and metastatic capacity of the prostate cancer cells		prostate cancer
hsa-miR-200a-5p	AR	-1.16865179527606	0.00105385823807419	-2.65514434874701	6.79656050811819e-11	miRNATAP	-0.334598099933557	1.9612268311013e-09	24391862	We identified miR-200 b as a downstream target of androgen receptor and linked its expression to decreased tumorigenicity and metastatic capacity of the prostate cancer cells		prostate cancer
hsa-miR-20a-5p	AR	0.854326758727003	5.04256669663285e-07	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.725850826781021	3.75624697520003e-10		NA	NA	NA
hsa-miR-20b-5p	AR	0.457668023910379	0.0285865211936156	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.370935607734088	0.000123857294145519		NA	NA	NA
hsa-miR-212-3p	AR	-0.288359631986802	0.100392159518997	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.443847001192348	0.000125366746710195	26553749	Aberrant coexpression of AR and hnRNPH1 and downregulation of miR-212 were detected in prostate tumors and correlate with disease progression in AA men compared with CA men; Ectopic expression of miR-212 mimics downregulated hnRNPH1 transcripts which in turn reduced expression of AR and its splice variant AR-V7 or AR3 in prostate cancer cells	progression	prostate cancer
hsa-miR-223-3p	AR	-0.996015099450654	2.19036606105147e-07	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.270639776981377	0.0094718955354678		NA	NA	NA
hsa-miR-2355-3p	AR	-0.471227472721651	0.00718598113738346	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.427293126649249	0.000223848171596396		NA	NA	NA
hsa-miR-2355-5p	AR	-0.233446678887995	0.157909851771338	-2.65514434874701	6.79656050811819e-11	MirTarget	-0.437198521693378	0.000370517694031262		NA	NA	NA
hsa-miR-301a-3p	AR	0.842910511640361	1.43446467417891e-06	-2.65514434874701	6.79656050811819e-11	mirMAP;miRNATAP	-1.0588536224098	3.18593631847295e-22	25940439	Mechanism dissection revealed infiltrating pre-adipocytes might function through down-regulation of the androgen receptor AR via modulation of miR-301a and then increase PCa cell invasion via induction of TGF-β1/Smad/MMP9 signals		prostate cancer
hsa-miR-30d-5p	AR	0.718283816348023	2.47422074061352e-08	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.363743448123229	0.0197401384707762	27683042	Inhibition of endogenous miR-30b-3p and miR-30d-5p enhanced AR expression and androgen-independent cell growth; MiR-30d-5p levels were inversely correlated with AR activity as measured by PSA mRNA in metastatic CRPC		prostate cancer
hsa-miR-320a	AR	0.325285936317332	0.0221415065838824	-2.65514434874701	6.79656050811819e-11	miRNATAP	-0.41997982993335	0.00333941695943416	27216188	Histone Deacetylase Inhibition in Prostate Cancer Triggers miR 320 Mediated Suppression of the Androgen Receptor; Among the upregulated miRNAs after OBP-801 treatment in the three prostate cancer cell lines miR-320a whose expression was significantly correlated with prognosis of prostate cancers P = 0.0185 was the most closely associated with AR expression; An miR-320a mimic suppressed AR protein expression together with growth suppression while anti-miR-320a oligonucleotide significantly abrogated the growth suppression by OBP-801 treatment; Our data demonstrated that OBP-801 effectively suppressed AR activity via epigenetic upregulation of miR-320a which resulted in tumor cell growth suppression of prostate cancers	worse prognosis	prostate cancer
hsa-miR-335-3p	AR	-0.275199247483111	0.106629165248783	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.650444164245457	3.25974667691925e-08		NA	NA	NA
hsa-miR-338-3p	AR	0.543135607704581	0.00461167747143826	-2.65514434874701	6.79656050811819e-11	miRanda	-0.729059276516499	1.50546291787853e-12		NA	NA	NA
hsa-miR-362-3p	AR	0.814007335895913	2.00108618836568e-09	-2.65514434874701	6.79656050811819e-11	miRanda	-0.304927941021783	0.0389352915896122		NA	NA	NA
hsa-miR-370-3p	AR	-0.996857940191938	0.00017929446914888	-2.65514434874701	6.79656050811819e-11	MirTarget	-0.233175013649537	0.00208656928383173		NA	NA	NA
hsa-miR-421	AR	0.941856334694081	6.12167297054077e-08	-2.65514434874701	6.79656050811819e-11	MirTarget;miRNATAP	-0.672039703264111	3.43253952026957e-09	26827675	A transcriptional target of androgen receptor miR 421 regulates proliferation and metabolism of prostate cancer cells; Expression of miR-421 was significantly suppressed by androgen treatment and correlated to AR expression in different prostate cancer cell lines; Furthermore androgen-activated AR could directly bind to androgen responsive element ARE of miR-421 as predicted by bioinformatics resources and demonstrated by ChIP and luciferase reporter assays		prostate cancer
hsa-miR-429	AR	-1.40262535827285	6.93982219171912e-05	-2.65514434874701	6.79656050811819e-11	miRNATAP	-0.301333461447338	1.3372893485692e-07		NA	NA	NA
hsa-miR-432-5p	AR	-0.536178819038888	0.0748623258271085	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.258158742479427	0.000126567740090846		NA	NA	NA
hsa-miR-452-3p	AR	1.76909792952222	2.98172274671408e-10	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.21354428366014	0.00252707647659238		NA	NA	NA
hsa-miR-454-3p	AR	0.668749059573955	2.42670710515113e-06	-2.65514434874701	6.79656050811819e-11	mirMAP;miRNATAP	-0.874523974883643	3.54420900390337e-10		NA	NA	NA
hsa-miR-493-5p	AR	-0.198321662045422	0.502870277689198	-2.65514434874701	6.79656050811819e-11	miRNATAP	-0.282704416281416	3.58967755631456e-05		NA	NA	NA
hsa-miR-502-5p	AR	0.892373335336396	1.7122694518919e-06	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.437043084487193	6.50844710490121e-05		NA	NA	NA
hsa-miR-629-3p	AR	-0.315338123880353	0.119091248294946	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.392793573688179	0.000134522955381614		NA	NA	NA
hsa-miR-660-5p	AR	0.989755850734071	5.69930767464937e-14	-2.65514434874701	6.79656050811819e-11	mirMAP	-0.400706257830207	0.00761423831094759		NA	NA	NA
hsa-miR-877-5p	AR	1.35669625926821	1.43008125755656e-11	-2.65514434874701	6.79656050811819e-11	MirTarget	-0.917752648911399	1.20481571930238e-20		NA	NA	NA
hsa-miR-9-5p	AR	1.26407994492898	8.53156156439881e-05	-2.65514434874701	6.79656050811819e-11	miRNATAP	-0.211097971723915	0.000718546507738222		NA	NA	NA
hsa-miR-93-5p	AR	1.39518349670953	2.84167728726712e-25	-2.65514434874701	6.79656050811819e-11	mirMAP	-1.11110841410929	8.39827342734125e-16		NA	NA	NA