miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-107 ACVR1 -0.143562673728446 0.855954506542642 -0.0612825819098344 0.925591973861133 miRanda -0.125887519879979 0.0228848814777652 NA NA NA hsa-miR-142-3p ACVR1 0.0379334054800466 0.978238829636286 -0.0612825819098344 0.925591973861133 miRanda -0.172852838404982 4.63924834277727e-09 NA NA NA hsa-miR-148b-3p ACVR1 -0.0576480395180932 0.948404126433176 -0.0612825819098344 0.925591973861133 MirTarget -0.319622886255051 7.58896425406712e-07 NA NA NA hsa-miR-16-2-3p ACVR1 -0.0660098106740605 0.907925706907323 -0.0612825819098344 0.925591973861133 mirMAP -0.11880854807492 0.00314941500903322 NA NA NA hsa-miR-186-5p ACVR1 -0.0306736693084426 0.975683742421399 -0.0612825819098344 0.925591973861133 miRNAWalker2_validate -0.299272079307512 3.58485999458496e-06 NA NA NA hsa-miR-197-3p ACVR1 -0.0729969354891438 0.944939337616665 -0.0612825819098344 0.925591973861133 miRNAWalker2_validate -0.105952833384726 0.0237414019775754 NA NA NA hsa-miR-19b-3p ACVR1 -0.021069663589266 0.98250214127355 -0.0612825819098344 0.925591973861133 miRNAWalker2_validate -0.16301819600189 0.000121791619431487 NA NA NA hsa-miR-30b-5p ACVR1 0.0520139321008006 0.961247392125848 -0.0612825819098344 0.925591973861133 MirTarget -0.17035386927547 0.00144204580990362 NA NA NA hsa-miR-30c-5p ACVR1 0.0319636127131169 0.977297378757393 -0.0612825819098344 0.925591973861133 MirTarget;miRNATAP -0.172942931996027 0.000999505213029316 NA NA NA hsa-miR-30d-5p ACVR1 0.00832663322567129 0.995690909022542 -0.0612825819098344 0.925591973861133 MirTarget;miRNATAP -0.135526542294846 0.0338073131299299 NA NA NA hsa-miR-30e-5p ACVR1 -0.000980722416395352 0.999509440260479 -0.0612825819098344 0.925591973861133 MirTarget -0.289901156255877 6.44315458744234e-07 NA NA NA hsa-miR-320a ACVR1 0.0409153600352639 0.972867457397282 -0.0612825819098344 0.925591973861133 miRanda -0.131608474562726 0.00356300072233225 NA NA NA hsa-miR-338-3p ACVR1 -0.114540979598038 0.914387568019032 -0.0612825819098344 0.925591973861133 MirTarget;PITA;miRanda;miRNATAP -0.112641819426467 5.38951169521245e-05 NA NA NA hsa-miR-362-3p ACVR1 0.080128943742904 0.76325400634285 -0.0612825819098344 0.925591973861133 miRanda -0.143373806608195 0.000183139629382229 NA NA NA hsa-miR-454-3p ACVR1 0.136203543900226 0.745492956399051 -0.0612825819098344 0.925591973861133 MirTarget;miRNATAP -0.122567492407184 0.00598777141747361 NA NA NA hsa-miR-590-3p ACVR1 -0.139003976504018 0.700453857398655 -0.0612825819098344 0.925591973861133 miRanda -0.213928432421181 2.87018618272604e-07 NA NA NA hsa-let-7d-5p ACVR1C 0.0441530979747347 0.965405408390825 -0.705621209992422 0.0366650143996265 MirTarget;miRNATAP -0.371336403983045 0.0493624582879621 NA NA NA hsa-let-7e-5p ACVR1C 0.19604957369004 0.877087810041183 -0.705621209992422 0.0366650143996265 MirTarget;miRNATAP -0.526388663406781 5.39996367642266e-05 NA NA NA hsa-let-7g-5p ACVR1C 0.0051000443410274 0.996492272103643 -0.705621209992422 0.0366650143996265 MirTarget;miRNATAP -0.477932486113053 0.0170541516919522 NA NA NA hsa-miR-129-5p ACVR1C -0.229611213821731 0.491303882606775 -0.705621209992422 0.0366650143996265 miRanda -0.176558357357172 0.00497788706986173 NA NA NA hsa-miR-130a-5p ACVR1C 0.384075718738944 0.082831396840774 -0.705621209992422 0.0366650143996265 miRNATAP -0.283702911585428 0.00143520521462514 NA NA NA hsa-miR-181b-5p ACVR1C 0.281236821240558 0.780421351344992 -0.705621209992422 0.0366650143996265 miRNATAP -0.309360477736448 0.0116556742362251 NA NA NA hsa-miR-181c-5p ACVR1C 0.348865067036308 0.609372579266645 -0.705621209992422 0.0366650143996265 miRNATAP -0.28007699326565 0.0271446780471679 NA NA NA hsa-miR-26b-5p ACVR1C -0.00510702880331593 0.996607798179271 -0.705621209992422 0.0366650143996265 MirTarget;miRNATAP -0.306419146406598 0.0364255571848354 NA NA NA hsa-miR-335-3p ACVR1C 0.0459461858975514 0.956171824626465 -0.705621209992422 0.0366650143996265 MirTarget -0.174687342227282 0.0435764325104022 NA NA NA hsa-miR-7-1-3p ACVR1C 0.0894020440145336 0.872338669592458 -0.705621209992422 0.0366650143996265 mirMAP -0.2582450322942 0.034526630951187 NA NA NA hsa-let-7i-5p ACVR2A 0.0354095877029117 0.974843999181856 0.0273073141259408 0.957281293814732 miRNATAP -0.207079520090979 0.0125640684340953 NA NA NA hsa-miR-142-3p ACVR2A 0.0379334054800466 0.978238829636286 0.0273073141259408 0.957281293814732 MirTarget;PITA;miRanda;miRNATAP -0.11373526951566 0.000425474664105896 NA NA NA hsa-miR-181a-5p ACVR2A 0.131241012385924 0.917256096248893 0.0273073141259408 0.957281293814732 MirTarget;miRNATAP -0.104421444220041 0.0349078591194672 NA NA NA hsa-miR-193b-5p ACVR2A 0.195824163276067 0.617832211448485 0.0273073141259408 0.957281293814732 MirTarget -0.127241351706988 1.40836327276366e-05 NA NA NA hsa-miR-21-5p ACVR2A 0.102402561735872 0.965099645724328 0.0273073141259408 0.957281293814732 miRNATAP -0.240840909377618 0.000401712397836834 NA NA NA hsa-miR-27a-3p ACVR2A 0.089292677549258 0.950107084866822 0.0273073141259408 0.957281293814732 miRNATAP -0.137083224856059 0.00462635846190231 NA NA NA hsa-miR-29a-3p ACVR2A 0.144361548745149 0.928458118904984 0.0273073141259408 0.957281293814732 miRNATAP -0.177427149767841 1.71531401479103e-05 NA NA NA hsa-miR-29a-5p ACVR2A 0.18117722740642 0.583528211572362 0.0273073141259408 0.957281293814732 mirMAP;miRNATAP -0.207760139267172 3.52568750633372e-06 NA NA NA hsa-miR-29b-3p ACVR2A 0.142303641653058 0.900102271992252 0.0273073141259408 0.957281293814732 miRNATAP -0.184897401721193 6.41112984142575e-06 NA NA NA hsa-miR-331-5p ACVR2A -0.0226759110418184 0.930254970397494 0.0273073141259408 0.957281293814732 PITA -0.109522149160177 0.0297559757600178 NA NA NA hsa-let-7b-3p ACVR2B 0.186120842161163 0.771959239770811 0.166970145132411 0.707391008181756 MirTarget -0.228531189240534 0.000185124223183222 NA NA NA hsa-let-7f-1-3p ACVR2B 0.172471926572875 0.566835368063954 0.166970145132411 0.707391008181756 MirTarget -0.196322516424578 0.000876968490228771 NA NA NA hsa-miR-142-5p ACVR2B -0.0238817383727534 0.977605999057627 0.166970145132411 0.707391008181756 PITA -0.173339765985091 7.86351099002201e-06 NA NA NA hsa-miR-342-5p ACVR2B 0.217497039611414 0.559186016369001 0.166970145132411 0.707391008181756 miRNATAP -0.180372232758672 0.000217363334100315 NA NA NA hsa-miR-455-3p ACVR2B 0.137296059937864 0.889752053946795 0.166970145132411 0.707391008181756 miRNATAP -0.138020916274632 0.000685269147463274 NA NA NA hsa-miR-455-5p ACVR2B 0.0747941504251086 0.916216237220049 0.166970145132411 0.707391008181756 PITA -0.160562082356719 0.000275840585572924 NA NA NA hsa-let-7a-5p BMP2 -0.00112050886779613 0.999528865119284 -0.200403402714368 0.729095849306884 TargetScan -0.42600513523593 0.0366775047671551 NA NA NA hsa-miR-106a-5p BMP2 -0.187436837607903 0.776596826979526 -0.200403402714368 0.729095849306884 miRNATAP -0.284756722505656 0.000196543267629134 NA NA NA hsa-miR-362-3p BMP2 0.080128943742904 0.76325400634285 -0.200403402714368 0.729095849306884 miRanda -0.390686913840248 0.000600723221602875 NA NA NA hsa-miR-378c BMP2 0.0461179468701558 0.91229972072848 -0.200403402714368 0.729095849306884 miRNATAP -0.281129605798991 0.00340183029023861 NA NA NA hsa-miR-429 BMP2 -0.202051344131673 0.830298580465583 -0.200403402714368 0.729095849306884 miRNATAP -0.316552444908905 0.000105772353880714 NA NA NA hsa-miR-142-3p BMP4 0.0379334054800466 0.978238829636286 -0.0562203534914547 0.88276074902024 PITA;miRanda -0.375958312329309 2.16964863280377e-05 NA NA NA hsa-miR-590-3p BMP4 -0.139003976504018 0.700453857398655 -0.0562203534914547 0.88276074902024 miRanda -0.369298014297492 0.00319363636714979 NA NA NA hsa-miR-125a-3p BMP7 0.119245934253913 0.752909794176976 -0.586521739119656 0.428403860553793 miRanda -0.602397019762289 1.60854190307016e-06 NA NA NA hsa-miR-30a-5p BMP7 0.278544146596978 0.86478919764261 -0.586521739119656 0.428403860553793 mirMAP;miRNATAP -0.837637094666436 2.22227369883976e-12 NA NA NA hsa-miR-338-3p BMP7 -0.114540979598038 0.914387568019032 -0.586521739119656 0.428403860553793 miRanda -0.675850252283759 3.5099234776835e-08 NA NA NA hsa-miR-616-5p BMP7 0.11767557301438 0.604342884687014 -0.586521739119656 0.428403860553793 mirMAP -0.305709380897436 0.0309538280482594 NA NA NA hsa-miR-142-3p BMP8A 0.0379334054800466 0.978238829636286 -0.018661850474583 0.959119826624489 miRNAWalker2_validate -0.151623785619638 0.0024673264370693 NA NA NA hsa-miR-30e-3p BMP8A 0.0448074101950908 0.9771684382341 -0.018661850474583 0.959119826624489 MirTarget -0.272991487072419 0.00121157832661015 NA NA NA hsa-miR-326 BMP8A -0.0800314759439991 0.80437788029153 -0.018661850474583 0.959119826624489 miRanda -0.120244523761685 0.00459378828407528 NA NA NA hsa-miR-330-5p BMP8A 0.00970192961000116 0.988324849760483 -0.018661850474583 0.959119826624489 miRanda -0.141064278836011 0.0139965406922921 NA NA NA hsa-miR-423-5p BMP8A -0.051106548346862 0.944746336776507 -0.018661850474583 0.959119826624489 MirTarget -0.183678196894596 0.0460179597781925 NA NA NA hsa-miR-125a-3p BMP8B 0.119245934253913 0.752909794176976 0.112259277440238 0.761015723558304 miRanda -0.132890299961019 0.0157961128424701 NA NA NA hsa-miR-125a-5p BMP8B 0.278586710959701 0.804894506541028 0.112259277440238 0.761015723558304 miRanda -0.21763357986147 0.00972666932519359 NA NA NA hsa-miR-150-5p BMP8B 0.182073863939202 0.880089818795655 0.112259277440238 0.761015723558304 mirMAP -0.101569952393627 0.020776607076679 NA NA NA hsa-miR-181a-5p BMP8B 0.131241012385924 0.917256096248893 0.112259277440238 0.761015723558304 mirMAP -0.174411820910534 0.0488363550243845 NA NA NA hsa-miR-181b-5p BMP8B 0.281236821240558 0.780421351344992 0.112259277440238 0.761015723558304 mirMAP -0.194068988394633 0.0182517761069697 NA NA NA hsa-miR-181c-5p BMP8B 0.348865067036308 0.609372579266645 0.112259277440238 0.761015723558304 mirMAP -0.178337622034896 0.0358007082300119 NA NA NA hsa-miR-26b-5p BMP8B -0.00510702880331593 0.996607798179271 0.112259277440238 0.761015723558304 miRNAWalker2_validate -0.338787540773238 0.000511841503220318 NA NA NA hsa-miR-455-5p BMP8B 0.0747941504251086 0.916216237220049 0.112259277440238 0.761015723558304 miRanda -0.189702790864636 0.00364777683255093 NA NA NA hsa-miR-942-5p BMPR1A 0.0791601534907405 0.861181740732696 0.101867392665399 0.858369720011301 MirTarget -0.115821943076165 0.0223255431579815 NA NA NA hsa-miR-142-5p BMPR1B -0.0238817383727534 0.977605999057627 -0.115293374360908 0.819512978534419 mirMAP -0.734195251953472 3.70209244281447e-09 NA NA NA hsa-miR-146b-5p BMPR1B 0.225394330441354 0.853572932708187 -0.115293374360908 0.819512978534419 miRanda -0.666457773194095 3.90750084541049e-05 NA NA NA hsa-miR-150-5p BMPR1B 0.182073863939202 0.880089818795655 -0.115293374360908 0.819512978534419 MirTarget -0.474315918794335 6.64615777439564e-07 NA NA NA hsa-miR-205-5p BMPR1B 0.06047221712031 0.970421803021215 -0.115293374360908 0.819512978534419 miRNATAP -0.30696104798101 2.09869521416875e-08 NA NA NA hsa-miR-23a-3p BMPR1B -0.000919962616247716 0.999510817457789 -0.115293374360908 0.819512978534419 mirMAP -0.604519323094653 0.0151563609476042 NA NA NA hsa-miR-23b-3p BMPR1B -0.0423426775157463 0.974391918147413 -0.115293374360908 0.819512978534419 mirMAP -0.738278706558228 0.000346932652828484 NA NA NA hsa-miR-24-3p BMPR1B -0.00454177962947533 0.997476967221205 -0.115293374360908 0.819512978534419 miRNATAP -0.553792517791316 0.00634597891344123 NA NA NA hsa-miR-374a-5p BMPR1B -0.0565188149022875 0.931710308972254 -0.115293374360908 0.819512978534419 MirTarget -0.875519236735069 0.000361012347481395 NA NA NA hsa-miR-590-3p BMPR1B -0.139003976504018 0.700453857398655 -0.115293374360908 0.819512978534419 miRanda;mirMAP -0.552426048195125 0.00204524961517634 NA NA NA hsa-miR-629-3p BMPR1B 0.264171606611622 0.479075142876712 -0.115293374360908 0.819512978534419 MirTarget -0.416162287016012 0.00285439024103792 NA NA NA hsa-let-7a-3p BMPR2 -0.0587284699785764 0.934080921687498 0.0729469883659375 0.925952199679967 MirTarget;miRNATAP -0.114706586890353 0.0164442212871709 NA NA NA hsa-let-7f-1-3p BMPR2 0.172471926572875 0.566835368063954 0.0729469883659375 0.925952199679967 MirTarget -0.123298671912875 0.00285602396296033 NA NA NA hsa-miR-106b-5p BMPR2 -0.114223082397499 0.918147136717927 0.0729469883659375 0.925952199679967 MirTarget;miRNATAP -0.118630186532809 0.0044306068125726 NA NA NA hsa-miR-146b-3p BMPR2 0.315037387100506 0.717101167551485 0.0729469883659375 0.925952199679967 MirTarget;PITA -0.129887166168285 0.0005867601546192 NA NA NA hsa-miR-148b-3p BMPR2 -0.0576480395180932 0.948404126433176 0.0729469883659375 0.925952199679967 mirMAP -0.196466429101429 0.000987067706586972 NA NA NA hsa-miR-16-2-3p BMPR2 -0.0660098106740605 0.907925706907323 0.0729469883659375 0.925952199679967 mirMAP -0.146205885014432 6.2092491962501e-05 NA NA NA hsa-miR-17-5p BMPR2 -0.000596233219692266 0.999589719956144 0.0729469883659375 0.925952199679967 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.123193636647238 0.000494673489159658 NA NA NA hsa-miR-19b-3p BMPR2 -0.021069663589266 0.98250214127355 0.0729469883659375 0.925952199679967 miRNAWalker2_validate;MirTarget;miRNATAP -0.150829353350739 9.76501280448681e-05 NA NA NA hsa-miR-20a-5p BMPR2 0.0114792099504992 0.991781949567624 0.0729469883659375 0.925952199679967 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.109933280976769 0.0012552170058051 NA NA NA hsa-miR-21-5p BMPR2 0.102402561735872 0.965099645724328 0.0729469883659375 0.925952199679967 miRNAWalker2_validate;miRTarBase;MirTarget -0.1214041231959 0.0368710131324604 NA NA NA hsa-miR-25-3p BMPR2 -0.0772543757825961 0.964382394841313 0.0729469883659375 0.925952199679967 miRNATAP -0.161936056023317 0.00181112605669761 NA NA NA hsa-miR-30b-5p BMPR2 0.0520139321008006 0.961247392125848 0.0729469883659375 0.925952199679967 mirMAP -0.165651429980918 0.000678402541773278 NA NA NA hsa-miR-30e-5p BMPR2 -0.000980722416395352 0.999509440260479 0.0729469883659375 0.925952199679967 mirMAP -0.152650979111587 0.00461355244700787 NA NA NA hsa-miR-32-5p BMPR2 0.0628705653766719 0.926491719877421 0.0729469883659375 0.925952199679967 miRNATAP -0.152990695015064 0.000157914766251291 NA NA NA hsa-miR-590-3p BMPR2 -0.139003976504018 0.700453857398655 0.0729469883659375 0.925952199679967 MirTarget;miRanda;mirMAP;miRNATAP -0.180484987835457 2.26482768248502e-06 NA NA NA hsa-miR-590-5p BMPR2 -0.173775001452706 0.734742724035795 0.0729469883659375 0.925952199679967 MirTarget;PITA;miRNATAP -0.148168305174109 0.000153211214789233 NA NA NA hsa-miR-92a-3p BMPR2 0.0335965904378064 0.984787550750779 0.0729469883659375 0.925952199679967 miRNAWalker2_validate;miRNATAP -0.198526920027066 1.013641786486e-05 NA NA NA hsa-miR-93-3p BMPR2 -0.0797448554472107 0.871437048494161 0.0729469883659375 0.925952199679967 miRNAWalker2_validate -0.111582243298826 0.00334043843071077 NA NA NA hsa-miR-93-5p BMPR2 -0.103495149722972 0.948829359383178 0.0729469883659375 0.925952199679967 miRNAWalker2_validate;MirTarget;miRNATAP -0.125581481915172 0.00184301830288687 NA NA NA hsa-miR-107 CDKN2B -0.143562673728446 0.855954506542642 4.93480973533522e-05 0.999952246437528 PITA -0.451661629246362 0.000176451976452473 NA NA NA hsa-miR-125a-3p CDKN2B 0.119245934253913 0.752909794176976 4.93480973533522e-05 0.999952246437528 miRanda -0.281235486977565 5.87183094847568e-06 NA NA NA hsa-miR-125a-5p CDKN2B 0.278586710959701 0.804894506541028 4.93480973533522e-05 0.999952246437528 miRanda -0.607767279625756 7.34559713840635e-11 NA NA NA hsa-miR-126-5p CDKN2B -0.112356604031394 0.897861032950143 4.93480973533522e-05 0.999952246437528 mirMAP -0.384730895689604 0.000468547465389506 NA NA NA hsa-miR-19a-3p CDKN2B -0.015707259355076 0.981874522841226 4.93480973533522e-05 0.999952246437528 mirMAP -0.141040432258969 0.0437577677669512 NA NA NA hsa-miR-19b-3p CDKN2B -0.021069663589266 0.98250214127355 4.93480973533522e-05 0.999952246437528 mirMAP -0.211754835088046 0.0238928593989622 NA NA NA hsa-miR-217 CDKN2B 0.0105356435591801 0.980745425485859 4.93480973533522e-05 0.999952246437528 miRanda -0.146340892670124 0.0011879794504395 NA NA NA hsa-miR-28-5p CDKN2B 0.112746603967525 0.895983904271527 4.93480973533522e-05 0.999952246437528 miRanda -0.813818647185525 5.20786465614388e-10 NA NA NA hsa-miR-335-3p CDKN2B 0.0459461858975514 0.956171824626465 4.93480973533522e-05 0.999952246437528 mirMAP -0.230132652662327 0.000461918630662828 NA NA NA hsa-miR-374b-5p CDKN2B -0.120825593958128 0.872556407127498 4.93480973533522e-05 0.999952246437528 miRNAWalker2_validate -0.427660032295754 0.000588414390873068 NA NA NA hsa-miR-375 CDKN2B -0.174547017686267 0.898985810873488 4.93480973533522e-05 0.999952246437528 miRNAWalker2_validate;miRNATAP -0.135134550270944 7.98570366612466e-07 NA NA NA hsa-miR-450b-5p CDKN2B 0.163570603240011 0.757515672607717 4.93480973533522e-05 0.999952246437528 mirMAP -0.269827235831244 0.00178266967612344 NA NA NA hsa-miR-495-3p CDKN2B -0.050331444566428 0.885500155910947 4.93480973533522e-05 0.999952246437528 MirTarget -0.177011624965662 0.00348969353672305 NA NA NA hsa-miR-501-3p CDKN2B -0.213232934691677 0.749134059424389 4.93480973533522e-05 0.999952246437528 PITA -0.382280585734888 9.20643371704555e-08 NA NA NA hsa-miR-501-5p CDKN2B -0.0281755984621284 0.914828113245766 4.93480973533522e-05 0.999952246437528 mirMAP -0.353195575048531 8.09502902784753e-06 NA NA NA hsa-miR-502-3p CDKN2B -0.0742971274545239 0.863623336074792 4.93480973533522e-05 0.999952246437528 PITA -0.501828823781054 7.10109662589701e-06 NA NA NA hsa-miR-576-5p CDKN2B 0.0337415476075185 0.945669616791829 4.93480973533522e-05 0.999952246437528 MirTarget -0.24385227531482 0.0135759150509429 NA NA NA hsa-miR-582-5p CDKN2B 0.0391293212300696 0.945368171372496 4.93480973533522e-05 0.999952246437528 miRNATAP -0.142565867298399 0.00622437078082883 NA NA NA hsa-miR-671-5p CDKN2B 0.062775438823834 0.83975558381974 4.93480973533522e-05 0.999952246437528 PITA -0.353451371274366 3.22699968328056e-05 NA NA NA hsa-miR-7-1-3p CDKN2B 0.0894020440145336 0.872338669592458 4.93480973533522e-05 0.999952246437528 MirTarget -0.357518494533497 0.000112620950429957 NA NA NA hsa-let-7f-5p CHRD -0.0472576778172282 0.977473451892863 0.229501993736541 0.546275706373129 MirTarget;miRNATAP -0.339788516779306 0.0171481040668123 NA NA NA hsa-let-7g-3p CHRD 0.13081027141585 0.832169598580217 0.229501993736541 0.546275706373129 MirTarget -0.2436040724261 0.0369202267768653 NA NA NA hsa-miR-21-3p CREBBP 0.070706380594066 0.962928202615693 0.121621710453233 0.886874739865251 MirTarget -0.1378273582574 1.08112070034993e-06 NA NA NA hsa-miR-590-3p CREBBP -0.139003976504018 0.700453857398655 0.121621710453233 0.886874739865251 PITA;miRanda;mirMAP;miRNATAP -0.100352894791816 0.00219317602458258 NA NA NA hsa-let-7d-5p DCN 0.0441530979747347 0.965405408390825 0.0841228727593268 0.919390093109807 MirTarget -0.693674106936328 0.000170980727532721 NA NA NA hsa-let-7g-5p DCN 0.0051000443410274 0.996492272103643 0.0841228727593268 0.919390093109807 MirTarget -0.508204108340296 0.00996310545099632 NA NA NA hsa-miR-3065-5p DCN -0.318966306994077 0.311417121022653 0.0841228727593268 0.919390093109807 mirMAP -0.138818256337503 0.0358238119275122 NA NA NA hsa-miR-374b-3p DCN 0.153435716373655 0.402834244204233 0.0841228727593268 0.919390093109807 MirTarget -0.284282235371128 0.0147683242188491 NA NA NA hsa-miR-421 DCN -0.0969235906133226 0.663567108256536 0.0841228727593268 0.919390093109807 miRanda -0.27580685200609 0.00668381401976743 NA NA NA hsa-miR-501-5p DCN -0.0281755984621284 0.914828113245766 0.0841228727593268 0.919390093109807 mirMAP -0.35541924818636 0.000536225854622283 NA NA NA hsa-miR-590-3p DCN -0.139003976504018 0.700453857398655 0.0841228727593268 0.919390093109807 MirTarget;PITA;miRanda;mirMAP -0.417033846886242 0.000464733684797091 NA NA NA hsa-miR-7-1-3p DCN 0.0894020440145336 0.872338669592458 0.0841228727593268 0.919390093109807 mirMAP -0.331009545534078 0.00582260375259807 NA NA NA hsa-let-7a-5p E2F5 -0.00112050886779613 0.999528865119284 -0.00797760240941403 0.979364040830441 MirTarget;TargetScan;miRNATAP -0.325132871878297 0.0224852990644336 NA NA NA hsa-let-7b-5p E2F5 0.161665753874088 0.927771425476349 -0.00797760240941403 0.979364040830441 miRNAWalker2_validate;MirTarget;miRNATAP -0.276412801214816 0.0102070191276974 NA NA NA hsa-let-7f-5p E2F5 -0.0472576778172282 0.977473451892863 -0.00797760240941403 0.979364040830441 MirTarget;miRNATAP -0.353852840088557 0.000664150120910199 NA NA NA hsa-let-7i-5p E2F5 0.0354095877029117 0.974843999181856 -0.00797760240941403 0.979364040830441 MirTarget;miRNATAP -0.494751518747998 0.00193678048367326 NA NA NA hsa-miR-1-3p E2F5 0.340155361125536 0.508493297069219 -0.00797760240941403 0.979364040830441 MirTarget -0.151433993301856 0.00306193575274417 NA NA NA hsa-miR-142-3p E2F5 0.0379334054800466 0.978238829636286 -0.00797760240941403 0.979364040830441 miRanda -0.168926633694876 0.00689492861438165 NA NA NA hsa-miR-199b-5p E2F5 0.0295106240253391 0.97471100218466 -0.00797760240941403 0.979364040830441 miRanda -0.126013460892835 0.0331182843237222 NA NA NA hsa-miR-205-5p E2F5 0.06047221712031 0.970421803021215 -0.00797760240941403 0.979364040830441 miRNAWalker2_validate;miRTarBase;miRNATAP -0.184708069923657 2.74621532953329e-12 21454583 The expression levels of E2F1 and E2F5 were correlated inversely with that of miR-205 in melanoma cell lines; miR-205 significantly suppressed the luciferase activity of reporter plasmids containing the 3'-UTR sequences complementary to either E2F1 or E2F5; Overexpression of miR-205 in melanoma cells reduced E2F1 and E2F5 protein levels melanoma hsa-miR-34c-5p E2F5 -0.146449591856554 0.765328802566255 -0.00797760240941403 0.979364040830441 MirTarget;PITA;miRanda;miRNATAP -0.157867299377243 8.51362892001314e-05 NA NA NA hsa-miR-148a-3p EP300 0.016749255538226 0.992725424032016 0.0073777725561639 0.992812890604336 miRNATAP -0.104185690998739 0.00975228544208279 NA NA NA hsa-miR-26b-5p EP300 -0.00510702880331593 0.996607798179271 0.0073777725561639 0.992812890604336 miRNAWalker2_validate;miRNATAP -0.133193686886669 0.0139568858207426 NA NA NA hsa-miR-30c-5p EP300 0.0319636127131169 0.977297378757393 0.0073777725561639 0.992812890604336 miRNAWalker2_validate -0.18542784496307 0.000897194160521004 NA NA NA hsa-miR-339-5p EP300 -0.0440073754970829 0.947512460035341 0.0073777725561639 0.992812890604336 miRanda -0.199156483102611 4.47682764951844e-07 NA NA NA hsa-miR-342-3p EP300 0.151626922605026 0.867631856166764 0.0073777725561639 0.992812890604336 MirTarget;PITA;miRanda;miRNATAP -0.115722711407846 0.00406603413994019 NA NA NA hsa-miR-361-3p EP300 0.0304329120700579 0.974956209185769 0.0073777725561639 0.992812890604336 PITA -0.135942435196129 0.0200803551179427 NA NA NA hsa-miR-374b-5p EP300 -0.120825593958128 0.872556407127498 0.0073777725561639 0.992812890604336 mirMAP;miRNATAP -0.159199926258203 0.00855691297646884 NA NA NA hsa-miR-590-3p EP300 -0.139003976504018 0.700453857398655 0.0073777725561639 0.992812890604336 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.136964991854083 0.00229030845745203 NA NA NA hsa-miR-338-5p FST -0.0570309768373674 0.852806138741879 0.890595305959792 0.12422662974915 MirTarget -0.456182858493687 0.000213836155315545 NA NA NA hsa-let-7g-5p GDF6 0.0051000443410274 0.996492272103643 0.16082724294229 0.786048985873035 MirTarget;miRNATAP -0.899439728625514 0.00341856573105334 NA NA NA hsa-miR-141-3p GDF6 0.14341518885497 0.909724976567544 0.16082724294229 0.786048985873035 TargetScan -0.301334268738362 0.0138982872642358 NA NA NA hsa-miR-200b-3p GDF6 0.00709506191350684 0.995560284306733 0.16082724294229 0.786048985873035 TargetScan -0.609131046562882 2.49506902870059e-06 NA NA NA hsa-miR-30a-3p GDF6 0.262869410871982 0.850239043174234 0.16082724294229 0.786048985873035 miRNATAP -0.228161926773645 0.0329530910063898 NA NA NA hsa-miR-30d-3p GDF6 0.19646108479447 0.479886265992696 0.16082724294229 0.786048985873035 miRNATAP -0.565739990285752 0.0153716911083853 NA NA NA hsa-miR-3607-3p GDF6 -0.0558689743911946 0.921122504786657 0.16082724294229 0.786048985873035 MirTarget;miRNATAP -0.400439942474613 0.00976032234657523 NA NA NA hsa-miR-429 GDF6 -0.202051344131673 0.830298580465583 0.16082724294229 0.786048985873035 PITA;miRanda;miRNATAP -0.536897304948851 9.0270313133678e-06 NA NA NA hsa-miR-532-3p GDF6 0.0299059710198204 0.962923289121957 0.16082724294229 0.786048985873035 PITA;miRNATAP -0.59653841850623 0.00112382468971625 NA NA NA hsa-miR-589-3p GDF6 0.0761143454315903 0.725564791705791 0.16082724294229 0.786048985873035 MirTarget -0.302894250812025 0.0291850731522832 NA NA NA hsa-miR-192-5p ID1 0.209901533380535 0.862196202010764 -0.267973000488215 0.780759944289864 miRNAWalker2_validate -0.136145277295878 0.000450814998396788 NA NA NA hsa-miR-338-5p ID1 -0.0570309768373674 0.852806138741879 -0.267973000488215 0.780759944289864 MirTarget;PITA;miRNATAP -0.12259161910328 0.0233648776303904 NA NA NA hsa-let-7a-3p ID2 -0.0587284699785764 0.934080921687498 0.00577787881952929 0.993520437452909 miRNATAP -0.332304595270933 0.000255934152081128 NA NA NA hsa-miR-139-5p ID2 -0.150924994419307 0.790741160689916 0.00577787881952929 0.993520437452909 miRanda -0.170162907716332 0.00711830840129372 NA NA NA hsa-miR-27a-3p ID2 0.089292677549258 0.950107084866822 0.00577787881952929 0.993520437452909 MirTarget;miRNATAP -0.360335443916806 3.57937005002133e-06 NA NA NA hsa-miR-320b ID2 0.0996601047414365 0.810359465912461 0.00577787881952929 0.993520437452909 miRanda -0.141657358225024 0.0297816707699256 NA NA NA hsa-miR-330-3p ID2 -0.011452549052418 0.970394129262563 0.00577787881952929 0.993520437452909 MirTarget;PITA;miRNATAP -0.211998117870452 0.000199415670908787 NA NA NA hsa-miR-335-3p ID2 0.0459461858975514 0.956171824626465 0.00577787881952929 0.993520437452909 MirTarget -0.185872652315649 0.000380455687029298 NA NA NA hsa-miR-455-3p ID2 0.137296059937864 0.889752053946795 0.00577787881952929 0.993520437452909 MirTarget;PITA;miRNATAP -0.159086590304116 0.003512126153271 NA NA NA hsa-miR-199b-5p ID3 0.0295106240253391 0.97471100218466 -0.267687338690688 0.726475855203414 miRanda -0.157482471011185 0.00400077975763686 NA NA NA hsa-miR-3065-3p ID3 -0.329809182990245 0.625678154834443 -0.267687338690688 0.726475855203414 miRNATAP -0.215967073130937 3.19710859005257e-06 NA NA NA hsa-miR-142-3p ID4 0.0379334054800466 0.978238829636286 0.365747154611058 0.450214901241161 miRanda -0.30254821236955 0.000206809160411308 NA NA NA hsa-miR-203a-3p ID4 -0.148899926796224 0.936624137891012 0.365747154611058 0.450214901241161 MirTarget -0.255138480807206 6.89558932429307e-08 NA NA NA hsa-miR-27a-3p ID4 0.089292677549258 0.950107084866822 0.365747154611058 0.450214901241161 miRNAWalker2_validate -0.428032886588549 0.000450255785596306 NA NA NA hsa-miR-330-5p ID4 0.00970192961000116 0.988324849760483 0.365747154611058 0.450214901241161 miRanda -0.444975540249968 1.51075784512091e-06 NA NA NA hsa-miR-342-3p ID4 0.151626922605026 0.867631856166764 0.365747154611058 0.450214901241161 MirTarget;PITA;miRanda -0.338565401869944 0.00099424882959107 24475217 miR 342 regulates BRCA1 expression through modulation of ID4 in breast cancer; To investigate at functional level the role of miR-342 in the pathogenesis of breast cancer we focused our attention on its "in silico" predicted putative target gene ID4 a transcription factor of the helix-loop-helix protein family whose expression is inversely correlated with that of ER; We functionally validated the interaction between ID4 and miR-342 in a reporter Luciferase system; Based on these findings we hypothesized that regulation of ID4 mediated by miR-342 could be involved in the pathogenesis of breast cancer by downregulating BRCA1 expression; Overexpression of miR-342 in these cells reduced ID4 and increased BRCA1 expression supporting a possible role of this mechanism in breast cancer; In the ER-positive MCF7 and in the BRCA1-mutant HCC1937 cell lines miR-342 over-expression only reduced ID4 breast cancer hsa-miR-629-3p ID4 0.264171606611622 0.479075142876712 0.365747154611058 0.450214901241161 MirTarget -0.356897688909299 6.00540805343868e-05 NA NA NA hsa-miR-125a-5p IFNG 0.278586710959701 0.804894506541028 0.510896404479397 0.252926275956767 miRanda -0.637406884218199 8.76838777034272e-05 NA NA NA hsa-miR-369-3p IFNG -0.205779736705628 0.5681772430766 0.510896404479397 0.252926275956767 PITA;miRNATAP -0.305363909941883 0.00283324153759366 NA NA NA hsa-miR-409-3p IFNG -0.245558039939782 0.611272253940472 0.510896404479397 0.252926275956767 miRNAWalker2_validate -0.434967349237788 0.000124210543621997 NA NA NA hsa-miR-429 IFNG -0.202051344131673 0.830298580465583 0.510896404479397 0.252926275956767 miRanda -0.299498705059905 0.00377911708833624 NA NA NA hsa-miR-10a-3p INHBA 0.442359308066539 0.192676160427887 0.0403878212250099 0.923318082753758 mirMAP -0.228868949828328 0.00288571997624358 NA NA NA hsa-miR-10b-5p INHBA -0.106695991042427 0.955221285625044 0.0403878212250099 0.923318082753758 miRNAWalker2_validate -0.375135520462904 0.00596419514318865 NA NA NA hsa-miR-125b-2-3p INHBA 0.0571303649835695 0.929289965924552 0.0403878212250099 0.923318082753758 mirMAP -0.157944790930006 0.0138376865661889 NA NA NA hsa-miR-148b-3p INHBA -0.0576480395180932 0.948404126433176 0.0403878212250099 0.923318082753758 miRNAWalker2_validate -0.667439513931159 0.00272176813701307 NA NA NA hsa-miR-16-2-3p INHBA -0.0660098106740605 0.907925706907323 0.0403878212250099 0.923318082753758 mirMAP -0.460254491787022 0.000754313391824958 NA NA NA hsa-miR-181c-5p INHBA 0.348865067036308 0.609372579266645 0.0403878212250099 0.923318082753758 mirMAP -0.327187664106844 0.0295723539209472 NA NA NA hsa-miR-195-3p INHBA -0.0817091054958705 0.737669463151026 0.0403878212250099 0.923318082753758 mirMAP -0.359920153494247 0.00156804274458257 NA NA NA hsa-miR-200b-3p INHBA 0.00709506191350684 0.995560284306733 0.0403878212250099 0.923318082753758 TargetScan -0.556231875088492 1.97398662453022e-08 NA NA NA hsa-miR-224-3p INHBA 0.349421935502662 0.348544864015699 0.0403878212250099 0.923318082753758 mirMAP -0.244901176503382 0.0107132106449266 NA NA NA hsa-miR-26a-5p INHBA 0.110457386875835 0.937612316892532 0.0403878212250099 0.923318082753758 mirMAP -0.482333762837731 0.0121541790978987 NA NA NA hsa-miR-3065-5p INHBA -0.318966306994077 0.311417121022653 0.0403878212250099 0.923318082753758 mirMAP -0.362079017770634 4.04665334650244e-06 NA NA NA hsa-miR-30b-5p INHBA 0.0520139321008006 0.961247392125848 0.0403878212250099 0.923318082753758 mirMAP -0.641790503573834 0.00040859319409002 NA NA NA hsa-miR-30c-5p INHBA 0.0319636127131169 0.977297378757393 0.0403878212250099 0.923318082753758 mirMAP -0.829638986336471 2.85124185439564e-06 NA NA NA hsa-miR-30d-5p INHBA 0.00832663322567129 0.995690909022542 0.0403878212250099 0.923318082753758 mirMAP -0.810002974024271 0.000171793130428081 NA NA NA hsa-miR-30e-5p INHBA -0.000980722416395352 0.999509440260479 0.0403878212250099 0.923318082753758 mirMAP -1.27059538225699 7.92305049877725e-11 NA NA NA hsa-miR-3607-3p INHBA -0.0558689743911946 0.921122504786657 0.0403878212250099 0.923318082753758 mirMAP -0.386722991000475 0.00117665769481931 NA NA NA hsa-miR-374a-5p INHBA -0.0565188149022875 0.931710308972254 0.0403878212250099 0.923318082753758 mirMAP -0.531291535768356 0.00725261558931535 NA NA NA hsa-miR-374b-5p INHBA -0.120825593958128 0.872556407127498 0.0403878212250099 0.923318082753758 mirMAP -0.397382374555169 0.0408507665343398 NA NA NA hsa-miR-664a-3p INHBA 0.0410470241619301 0.941262864923951 0.0403878212250099 0.923318082753758 mirMAP -0.466978716274 0.00658510269681794 NA NA NA hsa-let-7b-3p INHBB 0.186120842161163 0.771959239770811 0.030773127430912 0.944345339150256 mirMAP -0.463652659221676 0.0021376185872136 NA NA NA hsa-let-7f-1-3p INHBB 0.172471926572875 0.566835368063954 0.030773127430912 0.944345339150256 mirMAP -0.404972481178029 0.00541675367886755 NA NA NA hsa-miR-149-5p INHBB -0.271683019397853 0.730802056990334 0.030773127430912 0.944345339150256 miRNATAP -0.311217107683418 2.76274284748989e-05 NA NA NA hsa-miR-34c-5p INHBB -0.146449591856554 0.765328802566255 0.030773127430912 0.944345339150256 miRanda;miRNATAP -0.140882165290134 0.024781810834991 NA NA NA hsa-miR-944 INHBB -0.316321233715507 0.703644676773439 0.030773127430912 0.944345339150256 PITA;miRNATAP -0.308259024282992 2.31374161115698e-16 NA NA NA hsa-miR-34c-5p LEFTY1 -0.146449591856554 0.765328802566255 -0.082646742888455 0.860424380905189 miRanda -0.191448006205679 0.0136317827110864 NA NA NA hsa-miR-338-3p LEFTY2 -0.114540979598038 0.914387568019032 0.64160777164522 0.256422929107829 miRanda -0.335229774792844 0.0105440699603547 NA NA NA hsa-miR-339-5p LEFTY2 -0.0440073754970829 0.947512460035341 0.64160777164522 0.256422929107829 miRanda -0.686073023431591 8.44843734028557e-05 NA NA NA hsa-miR-421 LEFTY2 -0.0969235906133226 0.663567108256536 0.64160777164522 0.256422929107829 miRanda -0.627276884060026 0.000170299323727752 NA NA NA hsa-miR-141-3p LTBP1 0.14341518885497 0.909724976567544 0.24228210875282 0.760097894303191 MirTarget -0.123615104125198 0.0175201097951623 NA NA NA hsa-miR-142-5p LTBP1 -0.0238817383727534 0.977605999057627 0.24228210875282 0.760097894303191 PITA -0.182567913642117 0.00113007383986416 NA NA NA hsa-miR-148b-3p LTBP1 -0.0576480395180932 0.948404126433176 0.24228210875282 0.760097894303191 MirTarget -0.375783645725841 0.00215660060435271 NA NA NA hsa-miR-200a-3p LTBP1 0.0892611575123006 0.935584068432955 0.24228210875282 0.760097894303191 MirTarget -0.109072348275159 0.0264517346565534 NA NA NA hsa-miR-29b-1-5p LTBP1 0.0803356397596426 0.788717272901724 0.24228210875282 0.760097894303191 MirTarget -0.150062087396103 0.0181429284860624 NA NA NA hsa-miR-429 LTBP1 -0.202051344131673 0.830298580465583 0.24228210875282 0.760097894303191 miRanda;miRNATAP -0.104560275036067 0.0444037963112563 NA NA NA hsa-miR-148b-3p MAPK1 -0.0576480395180932 0.948404126433176 -0.0651808553348747 0.941739122403282 mirMAP -0.139901367015828 0.00442278516722453 NA NA NA hsa-miR-29b-2-5p MAPK1 0.0506576777608494 0.914446526694261 -0.0651808553348747 0.941739122403282 mirMAP -0.150888486209755 2.15475742904008e-05 NA NA NA hsa-miR-29c-3p MAPK1 -0.036782586594942 0.978186488964126 -0.0651808553348747 0.941739122403282 mirMAP -0.121961986993 4.61168241690927e-07 NA NA NA hsa-miR-30b-5p MAPK1 0.0520139321008006 0.961247392125848 -0.0651808553348747 0.941739122403282 mirMAP -0.107494044816223 0.00753809874561411 NA NA NA hsa-miR-30e-5p MAPK1 -0.000980722416395352 0.999509440260479 -0.0651808553348747 0.941739122403282 mirMAP -0.116090988644527 0.00885887810727849 NA NA NA hsa-miR-3913-5p MAPK1 -0.0226857734721915 0.929747532799218 -0.0651808553348747 0.941739122403282 mirMAP -0.108088444698366 0.00439552964093496 NA NA NA hsa-miR-335-5p MYC -0.0876284717522751 0.822280642381487 -0.345601208039382 0.694120829213557 miRNAWalker2_validate -0.177349242383061 0.0350467132879494 NA NA NA hsa-miR-34a-5p MYC -0.181045462699335 0.846186442909868 -0.345601208039382 0.694120829213557 miRNAWalker2_validate;miRTarBase -0.427487830189717 0.00161403194033986 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC -0.202051344131673 0.830298580465583 -0.345601208039382 0.694120829213557 miRNAWalker2_validate -0.351232938868747 9.84375821791447e-07 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-101-3p NOG -0.0193657214576124 0.99083006485154 0.416322086232494 0.4254382108629 miRNATAP -0.588806463252439 0.000125537379245868 NA NA NA hsa-miR-142-5p NOG -0.0238817383727534 0.977605999057627 0.416322086232494 0.4254382108629 miRNATAP -0.522147752334842 3.37362248010374e-07 NA NA NA hsa-miR-200b-3p NOG 0.00709506191350684 0.995560284306733 0.416322086232494 0.4254382108629 MirTarget;TargetScan -0.209041601335479 0.0424697035199917 NA NA NA hsa-miR-362-3p NOG 0.080128943742904 0.76325400634285 0.416322086232494 0.4254382108629 miRanda;miRNATAP -0.276871154011234 0.0383498324644039 NA NA NA hsa-miR-188-5p PITX2 0.104867166668688 0.681237247873533 -0.890119767349433 0.170555231314355 PITA -0.728008208319922 0.000353396687418111 NA NA NA hsa-miR-217 PITX2 0.0105356435591801 0.980745425485859 -0.890119767349433 0.170555231314355 miRanda -0.417759942604483 0.000567867786887708 NA NA NA hsa-miR-30a-3p PITX2 0.262869410871982 0.850239043174234 -0.890119767349433 0.170555231314355 miRNATAP -0.746671574404835 1.01775167632319e-07 NA NA NA hsa-miR-501-5p PITX2 -0.0281755984621284 0.914828113245766 -0.890119767349433 0.170555231314355 PITA;miRNATAP -0.494912501921518 0.0215121053530382 NA NA NA hsa-miR-425-5p PPP2CB 0.000321117322235942 0.999740269225925 -0.0578680806314837 0.944699297035275 miRNAWalker2_validate -0.110681790089799 1.64448494638146e-05 NA NA NA hsa-miR-590-3p PPP2CB -0.139003976504018 0.700453857398655 -0.0578680806314837 0.944699297035275 miRanda -0.128757858804767 5.16847568396067e-05 NA NA NA hsa-miR-125a-5p PPP2R1B 0.278586710959701 0.804894506541028 -0.113027615678996 0.861260770868741 PITA;miRanda -0.114930033410317 0.00930190483964423 NA NA NA hsa-miR-30e-3p PPP2R1B 0.0448074101950908 0.9771684382341 -0.113027615678996 0.861260770868741 mirMAP -0.109171912123649 0.0336857613488188 NA NA NA hsa-miR-452-5p PPP2R1B 0.171578505077356 0.861161653434281 -0.113027615678996 0.861260770868741 MirTarget -0.106017919286185 0.000183245518742969 NA NA NA hsa-miR-590-3p RBL1 -0.139003976504018 0.700453857398655 -0.0918067918373153 0.856064363076081 miRanda;mirMAP -0.146406335107204 0.0267326933843168 NA NA NA hsa-let-7f-2-3p RBL2 0.426923471821946 0.0178032872609366 -0.0321147944738334 0.967376790132685 MirTarget -0.110938571443043 0.00433507096732033 NA NA NA hsa-miR-106b-5p RBL2 -0.114223082397499 0.918147136717927 -0.0321147944738334 0.967376790132685 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.152134757968797 0.00122146155020016 NA NA NA hsa-miR-130a-5p RBL2 0.384075718738944 0.082831396840774 -0.0321147944738334 0.967376790132685 MirTarget -0.10715821321623 0.000810244476557906 NA NA NA hsa-miR-32-3p RBL2 0.397110511717083 0.0372089477602239 -0.0321147944738334 0.967376790132685 miRNATAP -0.128572933697516 0.000405541163046317 NA NA NA hsa-miR-335-3p RBL2 0.0459461858975514 0.956171824626465 -0.0321147944738334 0.967376790132685 MirTarget -0.116365907107437 0.000164887689801712 NA NA NA hsa-miR-335-5p RBL2 -0.0876284717522751 0.822280642381487 -0.0321147944738334 0.967376790132685 miRNAWalker2_validate -0.145019980739739 9.04060047371642e-06 NA NA NA hsa-miR-590-3p RBL2 -0.139003976504018 0.700453857398655 -0.0321147944738334 0.967376790132685 miRanda -0.194960999183418 6.4906101255289e-06 NA NA NA hsa-miR-664a-3p ROCK1 0.0410470241619301 0.941262864923951 0.0275429832375771 0.968942821712222 mirMAP -0.102372137778216 0.0323715103346566 NA NA NA hsa-let-7a-3p ROCK2 -0.0587284699785764 0.934080921687498 0.0501943558593458 0.93488001820405 mirMAP -0.287135080994927 0.00198598698276818 NA NA NA hsa-miR-142-3p ROCK2 0.0379334054800466 0.978238829636286 0.0501943558593458 0.93488001820405 PITA;miRanda;miRNATAP -0.159877164823284 0.00282210588614417 NA NA NA hsa-miR-142-5p ROCK2 -0.0238817383727534 0.977605999057627 0.0501943558593458 0.93488001820405 PITA -0.117236282243549 0.028405742008836 NA NA NA hsa-miR-224-3p ROCK2 0.349421935502662 0.348544864015699 0.0501943558593458 0.93488001820405 mirMAP -0.138248944552857 0.00579163824403207 NA NA NA hsa-miR-3607-3p ROCK2 -0.0558689743911946 0.921122504786657 0.0501943558593458 0.93488001820405 mirMAP -0.228150377670738 0.000240782728860781 NA NA NA hsa-miR-590-3p ROCK2 -0.139003976504018 0.700453857398655 0.0501943558593458 0.93488001820405 miRanda;mirMAP -0.284800877986152 0.000141234831462107 NA NA NA hsa-miR-107 RPS6KB1 -0.143562673728446 0.855954506542642 0.0772974274456661 0.911313771844833 PITA;miRanda -0.111469431880308 0.00608626394063609 NA NA NA hsa-miR-186-5p RPS6KB1 -0.0306736693084426 0.975683742421399 0.0772974274456661 0.911313771844833 MirTarget;miRNATAP -0.188202471127657 8.10651969496359e-05 NA NA NA hsa-miR-125a-5p RPS6KB2 0.278586710959701 0.804894506541028 -0.0642123724424106 0.933403566214688 miRanda -0.169895564703728 2.13927288529754e-05 NA NA NA hsa-miR-30a-5p SMAD1 0.278544146596978 0.86478919764261 0.115736016832037 0.861660086493423 miRNAWalker2_validate;miRTarBase -0.136305243025811 5.1078361443971e-06 NA NA NA hsa-miR-30c-5p SMAD1 0.0319636127131169 0.977297378757393 0.115736016832037 0.861660086493423 miRNAWalker2_validate;miRTarBase -0.118219273416957 0.0397672591212022 NA NA NA hsa-miR-590-5p SMAD1 -0.173775001452706 0.734742724035795 0.115736016832037 0.861660086493423 miRanda -0.106193842693607 0.0238833385538224 NA NA NA hsa-miR-374b-5p SMAD2 -0.120825593958128 0.872556407127498 -0.183947878301357 0.825065984244636 MirTarget -0.129583837300731 0.0115512001155785 NA NA NA hsa-let-7g-3p SMAD3 0.13081027141585 0.832169598580217 0.0983953677306744 0.910672251590309 mirMAP -0.257984897034794 2.44423650375142e-05 NA NA NA hsa-miR-17-5p SMAD3 -0.000596233219692266 0.999589719956144 0.0983953677306744 0.910672251590309 miRNAWalker2_validate -0.165009353618131 0.00461261808419179 NA NA NA hsa-miR-186-5p SMAD3 -0.0306736693084426 0.975683742421399 0.0983953677306744 0.910672251590309 mirMAP -0.742764319550064 2.12349457043014e-15 NA NA NA hsa-miR-188-5p SMAD3 0.104867166668688 0.681237247873533 0.0983953677306744 0.910672251590309 PITA -0.238758119317103 3.46346507109757e-06 NA NA NA hsa-miR-20a-3p SMAD3 0.00508369553133647 0.989627610532544 0.0983953677306744 0.910672251590309 MirTarget -0.113586093609298 0.0394412989574893 NA NA NA hsa-miR-28-5p SMAD3 0.112746603967525 0.895983904271527 0.0983953677306744 0.910672251590309 miRNATAP -0.238288702750939 0.00948140473131226 NA NA NA hsa-miR-29b-2-5p SMAD3 0.0506576777608494 0.914446526694261 0.0983953677306744 0.910672251590309 mirMAP -0.33018047859631 3.00181288669247e-06 NA NA NA hsa-miR-30a-3p SMAD3 0.262869410871982 0.850239043174234 0.0983953677306744 0.910672251590309 mirMAP -0.125743455849957 0.000500972339732145 NA NA NA hsa-miR-30d-3p SMAD3 0.19646108479447 0.479886265992696 0.0983953677306744 0.910672251590309 mirMAP -0.265215856067837 0.000784444342632096 NA NA NA hsa-miR-32-3p SMAD3 0.397110511717083 0.0372089477602239 0.0983953677306744 0.910672251590309 mirMAP -0.139443193805526 0.00854369021916498 NA NA NA hsa-miR-335-3p SMAD3 0.0459461858975514 0.956171824626465 0.0983953677306744 0.910672251590309 mirMAP -0.150203529209219 0.000833797912476475 NA NA NA hsa-miR-335-5p SMAD3 -0.0876284717522751 0.822280642381487 0.0983953677306744 0.910672251590309 miRNAWalker2_validate -0.170051000133026 0.000363968836124472 NA NA NA hsa-miR-345-5p SMAD3 0.0111886803838277 0.983411561857395 0.0983953677306744 0.910672251590309 mirMAP -0.193422457386819 3.24971867546412e-05 NA NA NA hsa-miR-501-5p SMAD3 -0.0281755984621284 0.914828113245766 0.0983953677306744 0.910672251590309 mirMAP -0.280514332977103 1.82290826802372e-07 NA NA NA hsa-miR-576-5p SMAD3 0.0337415476075185 0.945669616791829 0.0983953677306744 0.910672251590309 mirMAP -0.143556531357487 0.0337207679032995 NA NA NA hsa-miR-589-3p SMAD3 0.0761143454315903 0.725564791705791 0.0983953677306744 0.910672251590309 mirMAP -0.202014876353946 1.49389042617214e-05 NA NA NA hsa-miR-616-5p SMAD3 0.11767557301438 0.604342884687014 0.0983953677306744 0.910672251590309 mirMAP -0.241397292057418 2.69938790277874e-07 NA NA NA hsa-miR-671-5p SMAD3 0.062775438823834 0.83975558381974 0.0983953677306744 0.910672251590309 MirTarget -0.193412590030654 0.000928749665735432 NA NA NA hsa-miR-7-1-3p SMAD3 0.0894020440145336 0.872338669592458 0.0983953677306744 0.910672251590309 mirMAP -0.168365832898427 0.00819700709319524 NA NA NA hsa-miR-769-5p SMAD3 -0.0567559707186058 0.91501199901852 0.0983953677306744 0.910672251590309 miRNATAP -0.366412732630904 4.82674495052425e-07 NA NA NA hsa-miR-21-3p SMAD4 0.070706380594066 0.962928202615693 0.00271751914115637 0.997161566770899 mirMAP -0.112729088104479 0.00502861854832022 NA NA NA hsa-miR-27a-3p SMAD4 0.089292677549258 0.950107084866822 0.00271751914115637 0.997161566770899 MirTarget -0.132335336531126 0.00695151522053189 NA NA NA hsa-miR-32-5p SMAD4 0.0628705653766719 0.926491719877421 0.00271751914115637 0.997161566770899 mirMAP -0.119614186597926 0.0138442807407647 NA NA NA hsa-miR-590-3p SMAD4 -0.139003976504018 0.700453857398655 0.00271751914115637 0.997161566770899 MirTarget;PITA;miRanda;miRNATAP -0.108763251915953 0.0183914722302907 NA NA NA hsa-miR-142-3p SMAD5 0.0379334054800466 0.978238829636286 -0.128571363188972 0.859402786967655 miRanda -0.111458600261676 2.68471648745391e-05 NA NA NA hsa-miR-148b-3p SMAD5 -0.0576480395180932 0.948404126433176 -0.128571363188972 0.859402786967655 MirTarget -0.187860765240565 0.00120747050981635 NA NA NA hsa-miR-155-5p SMAD5 0.150755193213955 0.894622203994624 -0.128571363188972 0.859402786967655 miRNAWalker2_validate;miRTarBase -0.11374059022423 1.54512459183245e-05 20133617 Targeting of SMAD5 links microRNA 155 to the TGF beta pathway and lymphomagenesis; Using unbiased genome-wide approaches in DLBCL we discovered that the oncogenic microRNA-155 miR-155 directly targets the bone morphogenetic protein BMP-responsive transcriptional factor SMAD5; In confirmatory experiments RNAi-based SMAD5 knockdown recapitulated in vitro and in vivo the effects miR-155 overexpression; Furthermore in primary DLBCLs miR-155 overexpression inhibited SMAD5 expression and disrupted its activity as defined by individual and global analyses of its transcriptional targets; Together our data helped explain miR-155 function highlighted a hitherto unappreciated role of SMAD5 in lymphoma biology and defined a unique mechanism used by cancer cells to escape TGF-beta's growth-inhibitory effects lymphoma hsa-miR-374b-5p SMAD5 -0.120825593958128 0.872556407127498 -0.128571363188972 0.859402786967655 mirMAP -0.113890764454251 0.0245972061559062 NA NA NA hsa-miR-7-1-3p SMAD5 0.0894020440145336 0.872338669592458 -0.128571363188972 0.859402786967655 MirTarget;mirMAP -0.125172771217674 0.000874421069844358 NA NA NA hsa-miR-330-5p SMAD6 0.00970192961000116 0.988324849760483 -0.0601070487685371 0.859560133619708 miRanda -0.184917477614592 0.00299016941550084 NA NA NA hsa-miR-590-3p SMAD6 -0.139003976504018 0.700453857398655 -0.0601070487685371 0.859560133619708 miRanda -0.267326610379956 0.000457963476050754 NA NA NA hsa-miR-106a-5p SMAD7 -0.187436837607903 0.776596826979526 0.0386015924807976 0.947720041050149 miRNATAP -0.149963254737491 1.31781139734866e-06 NA NA NA hsa-miR-106b-5p SMAD7 -0.114223082397499 0.918147136717927 0.0386015924807976 0.947720041050149 miRNATAP -0.153866006306842 0.00543882440686572 27619676;25286029;22286770 MiR 106b promotes migration and invasion through enhancing EMT via downregulation of Smad 7 in Kazakh's esophageal squamous cell carcinoma; To understand the regulation between miR-106b and Smad 7 qRT-PCR and western blot were performed; Smad 7 was confirmed as a downstream target of miR-106b in our experimental setting; Our results indicated that miR-106b can promote migration and invasion of ESCC cells through enhancing EMT process via downregulation of Smad 7 suggesting that miR-106b can be a potential molecular phenotype in ESCC metastases;Smad7 which inhibits transforming growth factor-β TGF-β/Smad signaling as a target of the miR-106b family was downregulated in CD44+ cells;The miR 106b 25 cluster targets Smad7 activates TGF β signaling and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer metastasis;; esophageal cancer;gastric cancer;breast cancer hsa-miR-15b-5p SMAD7 0.00885606323496901 0.993510047034825 0.0386015924807976 0.947720041050149 miRNAWalker2_validate;MirTarget;miRNATAP -0.12276933574354 0.0240265474350386 NA NA NA hsa-miR-16-5p SMAD7 0.00657489810438072 0.99567095250359 0.0386015924807976 0.947720041050149 miRNAWalker2_validate;MirTarget;miRNATAP -0.11042422783014 0.0454276198480881 NA NA NA hsa-miR-200b-3p SMAD7 0.00709506191350684 0.995560284306733 0.0386015924807976 0.947720041050149 TargetScan;mirMAP -0.134092196812711 0.00017837402933657 NA NA NA hsa-miR-25-3p SMAD7 -0.0772543757825961 0.964382394841313 0.0386015924807976 0.947720041050149 miRNAWalker2_validate;MirTarget;miRNATAP -0.211174530736138 0.00218469576403061 23435373 MicroRNA 25 functions as a potential tumor suppressor in colon cancer by targeting Smad7; Furthermore bioinformatic predictions and experimental validation were used to identify Smad7 as a direct target of miR-25; Functional reverse experiments indicated that the antitumor effects of miR-25 were probably mediated by its repression of Smad7; These results suggest that miR-25 may function as a tumor suppressor by targeting Smad7 in colon cancer colon cancer hsa-miR-32-5p SMAD7 0.0628705653766719 0.926491719877421 0.0386015924807976 0.947720041050149 MirTarget;miRNATAP -0.150227679757323 0.00543246914204553 NA NA NA hsa-miR-34a-5p SMAD7 -0.181045462699335 0.846186442909868 0.0386015924807976 0.947720041050149 MirTarget -0.162394705492837 0.00963037319305692 NA NA NA hsa-miR-363-3p SMAD7 -0.352877796020056 0.605537508903605 0.0386015924807976 0.947720041050149 MirTarget;miRNATAP -0.129488951229613 8.8174349390813e-07 NA NA NA hsa-miR-590-3p SMAD7 -0.139003976504018 0.700453857398655 0.0386015924807976 0.947720041050149 miRanda -0.142111999176971 0.00557772133316168 NA NA NA hsa-miR-93-5p SMAD7 -0.103495149722972 0.948829359383178 0.0386015924807976 0.947720041050149 miRNATAP -0.112312147157656 0.0366812627519062 25371073 Mothers against decapentaplegic homolog 7 Smad7 as an essential molecular protein for nuclear accumulation of β-catenin in the canonical Wnt signaling pathway is predicted as a putative target gene of miR-93 by the silico method and demonstrated that it may be suppressed by targeting its 3'UTR; These findings showed that miR-93 suppresses colorectal cancer development via downregulating Wnt/β-catenin at least in part by targeting Smad7 colorectal cancer hsa-miR-96-5p SMAD7 -0.175083856582125 0.772848419789491 0.0386015924807976 0.947720041050149 TargetScan;miRNATAP -0.109077445631336 0.00187568919830877 NA NA NA hsa-let-7a-3p SMAD9 -0.0587284699785764 0.934080921687498 -0.203074959800062 0.628489766193187 mirMAP -0.442472512268732 0.00636653266609344 NA NA NA hsa-let-7f-1-3p SMAD9 0.172471926572875 0.566835368063954 -0.203074959800062 0.628489766193187 mirMAP -0.643058456662211 3.71020269166814e-06 NA NA NA hsa-miR-142-5p SMAD9 -0.0238817383727534 0.977605999057627 -0.203074959800062 0.628489766193187 mirMAP -0.455702968071563 6.87114862979984e-07 NA NA NA hsa-miR-155-5p SMAD9 0.150755193213955 0.894622203994624 -0.203074959800062 0.628489766193187 mirMAP -0.494912373572471 5.52020257308744e-08 NA NA NA hsa-miR-2355-5p SMAD9 -0.0334225912650465 0.961955002329649 -0.203074959800062 0.628489766193187 MirTarget -0.354388746551621 0.000914872258809983 NA NA NA hsa-miR-27a-3p SMAD9 0.089292677549258 0.950107084866822 -0.203074959800062 0.628489766193187 MirTarget;miRNATAP -0.476677374881021 0.000614418699263425 NA NA NA hsa-miR-3065-5p SMAD9 -0.318966306994077 0.311417121022653 -0.203074959800062 0.628489766193187 mirMAP -0.170622567202665 0.0185889320946337 NA NA NA hsa-miR-320c SMAD9 0.167820674105902 0.355392574548112 -0.203074959800062 0.628489766193187 MirTarget;miRanda -0.254690136563853 0.0314608616435477 NA NA NA hsa-miR-330-3p SMAD9 -0.011452549052418 0.970394129262563 -0.203074959800062 0.628489766193187 mirMAP;miRNATAP -0.307590268767431 0.00246486779468069 NA NA NA hsa-miR-3682-3p SMAD9 0.0447044540574996 0.832029098531057 -0.203074959800062 0.628489766193187 mirMAP -0.194190812232067 0.0484999440530096 NA NA NA hsa-miR-452-3p SMAD9 0.0419900877026573 0.928770349640822 -0.203074959800062 0.628489766193187 MirTarget -0.269259115360015 0.00104911081565079 NA NA NA hsa-miR-590-3p SMAD9 -0.139003976504018 0.700453857398655 -0.203074959800062 0.628489766193187 mirMAP -0.466193095735401 0.000359685283692022 NA NA NA hsa-miR-625-3p SMAD9 0.363565741261809 0.721911211147413 -0.203074959800062 0.628489766193187 mirMAP -0.295543877919876 0.0197436119264055 NA NA NA hsa-miR-629-3p SMAD9 0.264171606611622 0.479075142876712 -0.203074959800062 0.628489766193187 MirTarget -0.317166674054093 0.00186461760079121 NA NA NA hsa-miR-944 SMAD9 -0.316321233715507 0.703644676773439 -0.203074959800062 0.628489766193187 mirMAP -0.140004647532406 0.000216024062053183 NA NA NA hsa-miR-125a-5p SMURF1 0.278586710959701 0.804894506541028 -0.161396570061847 0.828402463134752 MirTarget;PITA;miRanda -0.164265398621157 2.25749305046991e-05 NA NA NA hsa-miR-505-5p SMURF1 0.132048093299481 0.68237831540037 -0.161396570061847 0.828402463134752 MirTarget -0.130251797014335 0.0001242339477502 NA NA NA hsa-miR-92b-3p SMURF1 0.0384207118756841 0.96614275955977 -0.161396570061847 0.828402463134752 miRNATAP -0.115623085220887 5.84662448355788e-05 NA NA NA hsa-miR-181b-5p SP1 0.281236821240558 0.780421351344992 0.00932782072799743 0.991961626774995 mirMAP -0.16244900785389 1.23268296448896e-08 NA NA NA hsa-miR-186-5p SP1 -0.0306736693084426 0.975683742421399 0.00932782072799743 0.991961626774995 miRNAWalker2_validate -0.173654685943994 8.59024450148812e-05 NA NA NA hsa-miR-324-5p SP1 -0.00384551840892744 0.994555888813517 0.00932782072799743 0.991961626774995 PITA -0.105352867542711 0.000170061785235409 26177288 Downregulation of ETS1 and SP1 mediated the inhibitory function of miR-324-5p on HCC migration and invasion liver cancer hsa-miR-335-5p SP1 -0.0876284717522751 0.822280642381487 0.00932782072799743 0.991961626774995 miRNAWalker2_validate -0.10287381677363 1.73733819355203e-06 23740614;21822301 Luciferase reporter assay and Western blot were to verify Bcl-w and SP1 as potential major target genes of miR-335; These results indicated that upregulation of miR-335 can simultaneously suppress the invasiveness and promote apoptosis of lung cancer cell A549 and H1299 by targeting Bcl-w and SP1;MicroRNA 335 acts as a metastasis suppressor in gastric cancer by targeting Bcl w and specificity protein 1; Taken together our results provide evidence that miR-335 might function as a metastasis suppressor in gastric cancer by targeting SP1 directly and indirectly through the Bcl-w-induced phosphoinositide 3-kinase-Akt-Sp1 pathway ;metastasis lung cancer;gastric cancer hsa-miR-374a-3p SP1 -0.0356287422567689 0.977336526097337 0.00932782072799743 0.991961626774995 mirMAP -0.11312774518121 0.00048897969800879 NA NA NA hsa-miR-99b-5p SP1 0.252065544764195 0.889030026769861 0.00932782072799743 0.991961626774995 miRNAWalker2_validate -0.133488124573425 2.75438359703961e-07 NA NA NA hsa-miR-28-5p TFDP1 0.112746603967525 0.895983904271527 0.141854398647067 0.880515184694402 miRanda -0.157053305977995 0.0136634788866607 NA NA NA hsa-miR-30a-3p TFDP1 0.262869410871982 0.850239043174234 0.141854398647067 0.880515184694402 MirTarget;miRNATAP -0.117651521698128 2.15488096931028e-06 NA NA NA hsa-miR-30a-5p TFDP1 0.278544146596978 0.86478919764261 0.141854398647067 0.880515184694402 MirTarget;miRNATAP -0.149270840448017 1.41969345460429e-07 NA NA NA hsa-miR-374b-5p TFDP1 -0.120825593958128 0.872556407127498 0.141854398647067 0.880515184694402 MirTarget -0.124240657647707 0.036127077097449 NA NA NA hsa-miR-491-5p TFDP1 0.166317478383631 0.336731694935094 0.141854398647067 0.880515184694402 miRanda -0.117208486553406 0.00358853398486073 NA NA NA hsa-miR-141-3p TGFB2 0.14341518885497 0.909724976567544 0.566186100407998 0.271734365119773 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.215624739416799 0.00999464963415708 NA NA NA hsa-miR-142-3p TGFB2 0.0379334054800466 0.978238829636286 0.566186100407998 0.271734365119773 miRNATAP -0.239982637825598 0.00829657759355293 NA NA NA hsa-miR-148b-3p TGFB2 -0.0576480395180932 0.948404126433176 0.566186100407998 0.271734365119773 MirTarget -0.652112155639784 0.000929853930431754 NA NA NA hsa-miR-200a-3p TGFB2 0.0892611575123006 0.935584068432955 0.566186100407998 0.271734365119773 MirTarget;miRNATAP -0.351128170275698 7.00885632360109e-06 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 -0.148899926796224 0.936624137891012 0.566186100407998 0.271734365119773 MirTarget -0.267521839692763 3.62940840958117e-07 NA NA NA hsa-miR-2277-5p TGFB2 -0.171583140840729 0.433330833775605 0.566186100407998 0.271734365119773 MirTarget -0.249573719882911 0.00777879243940924 NA NA NA hsa-miR-362-3p TGFB2 0.080128943742904 0.76325400634285 0.566186100407998 0.271734365119773 miRanda -0.252409907074068 0.0301240629015872 NA NA NA hsa-miR-362-5p TGFB2 -0.242502435420941 0.589336334764763 0.566186100407998 0.271734365119773 MirTarget -0.314690950040788 0.00297612558507577 NA NA NA hsa-miR-375 TGFB2 -0.174547017686267 0.898985810873488 0.566186100407998 0.271734365119773 miRNAWalker2_validate -0.113027113272895 0.00302877404950613 NA NA NA hsa-miR-429 TGFB2 -0.202051344131673 0.830298580465583 0.566186100407998 0.271734365119773 miRNATAP -0.317868138018968 0.000128726503171991 NA NA NA hsa-miR-454-3p TGFB2 0.136203543900226 0.745492956399051 0.566186100407998 0.271734365119773 MirTarget;miRNATAP -0.327134482586007 0.0150919225078625 NA NA NA hsa-miR-500a-5p TGFB2 -0.0771520921860445 0.817551406374847 0.566186100407998 0.271734365119773 mirMAP -0.329451267369997 0.00832586461531593 NA NA NA hsa-miR-500b-5p TGFB2 -0.0791448935498895 0.812969091165584 0.566186100407998 0.271734365119773 MirTarget -0.327405186316064 0.00868447231417683 NA NA NA hsa-miR-616-5p TGFB2 0.11767557301438 0.604342884687014 0.566186100407998 0.271734365119773 mirMAP -0.189478149280231 0.0488014870593231 NA NA NA hsa-miR-9-3p TGFB2 -0.569626685515492 0.198367177172169 0.566186100407998 0.271734365119773 MirTarget -0.125746331392832 0.0346375662627605 NA NA NA hsa-let-7f-1-3p TGFB3 0.172471926572875 0.566835368063954 0.0926299234558363 0.863400927842925 MirTarget -0.28544584743246 0.000437940636180159 NA NA NA hsa-miR-151a-5p TGFB3 0.0988194192231999 0.902720509393389 0.0926299234558363 0.863400927842925 MirTarget -0.500615620870658 2.12682352848945e-07 NA NA NA hsa-miR-629-3p TGFB3 0.264171606611622 0.479075142876712 0.0926299234558363 0.863400927842925 MirTarget -0.241806561248301 3.8838732840276e-05 NA NA NA hsa-let-7b-5p TGFBR1 0.161665753874088 0.927771425476349 0.161844663138844 0.832687991531839 miRNATAP -0.242601587479934 0.000517890990887836 27234654 rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1 which might provide a functional basis for the association in MSS HNPCC; In luciferase assays the risk-associated allele for rs868 was associated with half the luciferase expression in the presence of miRNA let-7b-5p compared with protective allele suggesting more binding of let-7b-5p and less TGFBR1 expression colorectal cancer hsa-let-7c-5p TGFBR1 0.126437896243322 0.92983249783551 0.161844663138844 0.832687991531839 miRNAWalker2_validate;miRTarBase -0.141642653096274 9.4282969596595e-06 NA NA NA hsa-let-7g-5p TGFBR1 0.0051000443410274 0.996492272103643 0.161844663138844 0.832687991531839 miRNATAP -0.267873123242374 0.00450205280436413 NA NA NA hsa-miR-101-3p TGFBR1 -0.0193657214576124 0.99083006485154 0.161844663138844 0.832687991531839 miRNAWalker2_validate;miRNATAP -0.25766117737473 1.65614003073399e-05 NA NA NA hsa-miR-101-5p TGFBR1 -0.0321211519940898 0.929098972930411 0.161844663138844 0.832687991531839 mirMAP -0.147066901987004 0.00277627040116552 NA NA NA hsa-miR-128-3p TGFBR1 0.0105197831892774 0.991049592106106 0.161844663138844 0.832687991531839 miRNAWalker2_validate;miRTarBase -0.218506283449698 0.000352839376558225 NA NA NA hsa-miR-130b-3p TGFBR1 -0.10221778777009 0.86290232287018 0.161844663138844 0.832687991531839 miRNATAP -0.119162445421437 0.0143458308514524 NA NA NA hsa-miR-186-5p TGFBR1 -0.0306736693084426 0.975683742421399 0.161844663138844 0.832687991531839 mirMAP -0.227217146959954 0.0101798716638516 NA NA NA hsa-miR-200b-3p TGFBR1 0.00709506191350684 0.995560284306733 0.161844663138844 0.832687991531839 mirMAP -0.254716587127543 6.86106889972148e-11 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-3065-5p TGFBR1 -0.318966306994077 0.311417121022653 0.161844663138844 0.832687991531839 mirMAP -0.111612566907259 0.000387470900601915 NA NA NA hsa-miR-361-5p TGFBR1 -0.18651036457623 0.854413202155139 0.161844663138844 0.832687991531839 miRanda;mirMAP;miRNATAP -0.236124496506177 0.00538272648027843 NA NA NA hsa-miR-374a-5p TGFBR1 -0.0565188149022875 0.931710308972254 0.161844663138844 0.832687991531839 mirMAP -0.235099661936825 0.0027662227971746 NA NA NA hsa-miR-374b-5p TGFBR1 -0.120825593958128 0.872556407127498 0.161844663138844 0.832687991531839 mirMAP -0.196695985221129 0.0107478368749896 NA NA NA hsa-miR-429 TGFBR1 -0.202051344131673 0.830298580465583 0.161844663138844 0.832687991531839 miRanda;miRNATAP -0.219958031472476 1.89353165194703e-09 NA NA NA hsa-miR-452-5p TGFBR1 0.171578505077356 0.861161653434281 0.161844663138844 0.832687991531839 mirMAP -0.12029641667783 0.00160222545222133 NA NA NA hsa-miR-106a-5p TGFBR2 -0.187436837607903 0.776596826979526 0.263125396208763 0.721677023750785 miRTarBase;miRNATAP -0.150075579446973 0.000678032994747311 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 -0.114223082397499 0.918147136717927 0.263125396208763 0.721677023750785 miRNATAP -0.322471465860215 3.16067025691578e-05 NA NA NA hsa-miR-130b-3p TGFBR2 -0.10221778777009 0.86290232287018 0.263125396208763 0.721677023750785 miRNAWalker2_validate;miRNATAP -0.213593769351299 0.000481445052465677 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 -0.000596233219692266 0.999589719956144 0.263125396208763 0.721677023750785 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.215187086531778 0.00117456700436254 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-18a-5p TGFBR2 -0.192028568618394 0.739225908511128 0.263125396208763 0.721677023750785 miRNAWalker2_validate -0.135343234498317 0.0158042568581437 NA NA NA hsa-miR-19a-3p TGFBR2 -0.015707259355076 0.981874522841226 0.263125396208763 0.721677023750785 miRNAWalker2_validate;miRNATAP -0.114838162156062 0.0351708776182258 NA NA NA hsa-miR-19b-3p TGFBR2 -0.021069663589266 0.98250214127355 0.263125396208763 0.721677023750785 miRNAWalker2_validate;miRNATAP -0.234916804375819 0.0012466880966742 NA NA NA hsa-miR-20a-5p TGFBR2 0.0114792099504992 0.991781949567624 0.263125396208763 0.721677023750785 miRNAWalker2_validate;miRTarBase;miRNATAP -0.20359230487236 0.00142468050698815 NA NA NA hsa-miR-23a-3p TGFBR2 -0.000919962616247716 0.999510817457789 0.263125396208763 0.721677023750785 miRNATAP -0.3112107869471 0.00186820770972094 NA NA NA hsa-miR-23b-3p TGFBR2 -0.0423426775157463 0.974391918147413 0.263125396208763 0.721677023750785 miRNATAP -0.396202249615838 1.57688737786639e-06 NA NA NA hsa-miR-33a-3p TGFBR2 0.0330412673925473 0.887935183776314 0.263125396208763 0.721677023750785 mirMAP -0.339046189283903 6.57537246748805e-10 NA NA NA hsa-miR-340-5p TGFBR2 -0.0974274402696707 0.851532876458098 0.263125396208763 0.721677023750785 mirMAP -0.166384599375896 0.0138225168393814 NA NA NA hsa-miR-429 TGFBR2 -0.202051344131673 0.830298580465583 0.263125396208763 0.721677023750785 miRNATAP -0.154633278802292 0.00105886610005129 NA NA NA hsa-miR-454-3p TGFBR2 0.136203543900226 0.745492956399051 0.263125396208763 0.721677023750785 miRNATAP -0.167813642713129 0.0280513088873595 NA NA NA hsa-miR-502-5p TGFBR2 -0.399402466528722 0.0371413760055171 0.263125396208763 0.721677023750785 miRNATAP -0.208965899672639 0.000640450504063216 NA NA NA hsa-miR-590-3p TGFBR2 -0.139003976504018 0.700453857398655 0.263125396208763 0.721677023750785 miRanda -0.257641439028576 0.000348477751441795 NA NA NA hsa-miR-590-5p TGFBR2 -0.173775001452706 0.734742724035795 0.263125396208763 0.721677023750785 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.215019200724794 0.00350246324243056 NA NA NA hsa-miR-9-3p TGFBR2 -0.569626685515492 0.198367177172169 0.263125396208763 0.721677023750785 miRNATAP -0.160602299630754 1.35393247444156e-06 NA NA NA hsa-miR-9-5p TGFBR2 -0.273546060420712 0.860070397379663 0.263125396208763 0.721677023750785 miRNATAP -0.159363587250353 4.39117866793099e-08 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-92a-3p TGFBR2 0.0335965904378064 0.984787550750779 0.263125396208763 0.721677023750785 miRNAWalker2_validate -0.35871093164404 2.09836401920038e-05 NA NA NA hsa-miR-93-5p TGFBR2 -0.103495149722972 0.948829359383178 0.263125396208763 0.721677023750785 miRNAWalker2_validate;miRNATAP -0.331832507260209 9.43453774065979e-06 NA NA NA hsa-let-7a-5p THBS1 -0.00112050886779613 0.999528865119284 -0.180808417582165 0.835885927809113 miRNAWalker2_validate;TargetScan -0.497243904586914 0.00492292853577542 NA NA NA hsa-let-7b-5p THBS1 0.161665753874088 0.927771425476349 -0.180808417582165 0.835885927809113 miRNAWalker2_validate -0.295885346124448 0.027277440657787 NA NA NA hsa-let-7d-5p THBS1 0.0441530979747347 0.965405408390825 -0.180808417582165 0.835885927809113 miRNAWalker2_validate -0.35203665179998 0.0381821983604575 NA NA NA hsa-miR-16-1-3p THBS1 -0.0202502748147722 0.95639903673924 -0.180808417582165 0.835885927809113 MirTarget -0.643028399066049 3.09438933664662e-09 NA NA NA hsa-miR-17-5p THBS1 -0.000596233219692266 0.999589719956144 -0.180808417582165 0.835885927809113 miRNAWalker2_validate -0.267945077391595 0.00757970547802144 NA NA NA hsa-miR-182-5p THBS1 -0.123533474001965 0.944870865201631 -0.180808417582165 0.835885927809113 MirTarget -0.241099584124763 0.000765040193303936 24053448 Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells metastasis colon cancer hsa-miR-186-5p THBS1 -0.0306736693084426 0.975683742421399 -0.180808417582165 0.835885927809113 mirMAP -0.462978112860335 0.00599316633809753 NA NA NA hsa-miR-19a-3p THBS1 -0.015707259355076 0.981874522841226 -0.180808417582165 0.835885927809113 MirTarget;mirMAP -0.199426716244453 0.0152276681051316 NA NA NA hsa-miR-19b-3p THBS1 -0.021069663589266 0.98250214127355 -0.180808417582165 0.835885927809113 MirTarget;mirMAP -0.333448340944079 0.00241856130914615 NA NA NA hsa-miR-200a-5p THBS1 0.0561869662734349 0.964453732315041 -0.180808417582165 0.835885927809113 MirTarget -0.485719624657622 5.54901388898712e-11 NA NA NA hsa-miR-200b-5p THBS1 0.051308474915948 0.937793950344497 -0.180808417582165 0.835885927809113 MirTarget -0.501001329221048 9.13787343375865e-12 NA NA NA hsa-miR-20a-5p THBS1 0.0114792099504992 0.991781949567624 -0.180808417582165 0.835885927809113 miRNAWalker2_validate -0.307672252327679 0.00140150807491854 NA NA NA hsa-miR-3065-5p THBS1 -0.318966306994077 0.311417121022653 -0.180808417582165 0.835885927809113 MirTarget -0.227705987060518 0.000143233633612563 NA NA NA hsa-miR-32-5p THBS1 0.0628705653766719 0.926491719877421 -0.180808417582165 0.835885927809113 mirMAP -0.296572650133784 0.0100039646653493 NA NA NA hsa-miR-33a-3p THBS1 0.0330412673925473 0.887935183776314 -0.180808417582165 0.835885927809113 MirTarget;mirMAP -0.24999380439174 0.00320886077009575 NA NA NA hsa-miR-375 THBS1 -0.174547017686267 0.898985810873488 -0.180808417582165 0.835885927809113 miRanda -0.104064726462059 0.00140403889155616 NA NA NA hsa-miR-500a-5p THBS1 -0.0771520921860445 0.817551406374847 -0.180808417582165 0.835885927809113 mirMAP -0.360122797705364 0.000716954259923395 NA NA NA hsa-miR-576-5p THBS1 0.0337415476075185 0.945669616791829 -0.180808417582165 0.835885927809113 mirMAP -0.371752416748424 0.00133090246897115 NA NA NA hsa-miR-590-3p THBS1 -0.139003976504018 0.700453857398655 -0.180808417582165 0.835885927809113 miRanda -0.305195275125083 0.00517237635189344 NA NA NA hsa-miR-616-5p THBS1 0.11767557301438 0.604342884687014 -0.180808417582165 0.835885927809113 mirMAP -0.253411231221945 0.00197529844240196 NA NA NA hsa-miR-92a-3p THBS1 0.0335965904378064 0.984787550750779 -0.180808417582165 0.835885927809113 miRNAWalker2_validate -0.313123627363836 0.0148198638493974 NA NA NA hsa-miR-106a-5p THBS2 -0.187436837607903 0.776596826979526 -0.206857963363997 0.772060968253302 MirTarget -0.336063474905193 2.56551669416365e-07 NA NA NA hsa-miR-106b-5p THBS2 -0.114223082397499 0.918147136717927 -0.206857963363997 0.772060968253302 MirTarget -0.754072944240837 2.88430240077148e-11 NA NA NA hsa-miR-142-5p THBS2 -0.0238817383727534 0.977605999057627 -0.206857963363997 0.772060968253302 mirMAP -0.208949988681772 0.00645371511907511 NA NA NA hsa-miR-146b-5p THBS2 0.225394330441354 0.853572932708187 -0.206857963363997 0.772060968253302 miRanda -0.216014529457816 0.0285101129782403 NA NA NA hsa-miR-16-2-3p THBS2 -0.0660098106740605 0.907925706907323 -0.206857963363997 0.772060968253302 mirMAP -0.678064085425023 1.06849736981054e-11 NA NA NA hsa-miR-17-5p THBS2 -0.000596233219692266 0.999589719956144 -0.206857963363997 0.772060968253302 MirTarget;TargetScan -0.460832414079987 2.70142073659636e-06 NA NA NA hsa-miR-182-5p THBS2 -0.123533474001965 0.944870865201631 -0.206857963363997 0.772060968253302 MirTarget;miRNATAP -0.185107388497314 0.00936294018881331 NA NA NA hsa-miR-20a-5p THBS2 0.0114792099504992 0.991781949567624 -0.206857963363997 0.772060968253302 MirTarget -0.415858722079042 1.12986282215266e-05 NA NA NA hsa-miR-20b-5p THBS2 -0.246206150607389 0.757367416017597 -0.206857963363997 0.772060968253302 MirTarget -0.199742215607688 2.8796635402953e-05 NA NA NA hsa-miR-29b-3p THBS2 0.142303641653058 0.900102271992252 -0.206857963363997 0.772060968253302 MirTarget -0.229102488868415 0.0201260250926879 NA NA NA hsa-miR-32-3p THBS2 0.397110511717083 0.0372089477602239 -0.206857963363997 0.772060968253302 miRNATAP -0.311183273683396 0.000549233998665121 NA NA NA hsa-miR-335-3p THBS2 0.0459461858975514 0.956171824626465 -0.206857963363997 0.772060968253302 MirTarget;mirMAP -0.238234138626814 0.00191001264899203 NA NA NA hsa-miR-3614-5p THBS2 0.190981959707294 0.593357864966094 -0.206857963363997 0.772060968253302 miRNATAP -0.20657913597438 0.000767513919935484 NA NA NA hsa-miR-590-3p THBS2 -0.139003976504018 0.700453857398655 -0.206857963363997 0.772060968253302 miRanda;mirMAP -0.366044680216134 0.000684664156327022 NA NA NA hsa-miR-590-5p THBS2 -0.173775001452706 0.734742724035795 -0.206857963363997 0.772060968253302 miRanda -0.401872758797421 0.000247068390424525 NA NA NA hsa-miR-93-5p THBS2 -0.103495149722972 0.948829359383178 -0.206857963363997 0.772060968253302 MirTarget -0.540936215734632 1.26073372180003e-06 NA NA NA hsa-miR-96-5p THBS2 -0.175083856582125 0.772848419789491 -0.206857963363997 0.772060968253302 TargetScan;miRNATAP -0.298099877132397 5.09583790054224e-05 NA NA NA hsa-miR-423-5p THBS3 -0.051106548346862 0.944746336776507 0.034088787934202 0.951546752155211 PITA;miRNATAP -0.133376765620382 0.0391467361119457 NA NA NA hsa-miR-550a-5p THBS3 0.00212046922868558 0.994910856220391 0.034088787934202 0.951546752155211 MirTarget -0.103051342949095 0.00766263723128083 NA NA NA hsa-miR-142-3p THBS4 0.0379334054800466 0.978238829636286 -0.302128364280161 0.451414354848524 miRanda -0.355816324499892 0.000893784144159221 NA NA NA hsa-miR-320b THBS4 0.0996601047414365 0.810359465912461 -0.302128364280161 0.451414354848524 miRanda -0.376591407193519 0.0045449911696931 NA NA NA hsa-miR-320c THBS4 0.167820674105902 0.355392574548112 -0.302128364280161 0.451414354848524 miRanda -0.378120083552424 0.00534438405126932 NA NA NA hsa-miR-361-5p TNF -0.18651036457623 0.854413202155139 0.392314389091534 0.230133702403534 miRanda -0.699393715835311 3.55980064084335e-05 NA NA NA hsa-miR-429 TNF -0.202051344131673 0.830298580465583 0.392314389091534 0.230133702403534 miRNATAP -0.166672367413636 0.0271661300621378 NA NA NA hsa-miR-654-3p TNF -0.21962598164265 0.691692134557376 0.392314389091534 0.230133702403534 miRNATAP -0.184952039903252 0.006307888857058 NA NA NA hsa-let-7a-3p ZFYVE16 -0.0587284699785764 0.934080921687498 0.0160524466554293 0.981290006166023 MirTarget;mirMAP;miRNATAP -0.170912861749384 1.07335028178481e-05 NA NA NA hsa-let-7f-1-3p ZFYVE16 0.172471926572875 0.566835368063954 0.0160524466554293 0.981290006166023 MirTarget;mirMAP -0.139117709102028 3.68760710387035e-05 NA NA NA hsa-miR-221-3p ZFYVE16 0.210010408899636 0.848193921049323 0.0160524466554293 0.981290006166023 MirTarget -0.143554177116192 2.2255337462971e-10 NA NA NA hsa-miR-222-3p ZFYVE16 0.381289410912482 0.65651572211416 0.0160524466554293 0.981290006166023 miRNAWalker2_validate;MirTarget -0.131338724635918 1.64775781925967e-08 NA NA NA hsa-miR-374a-5p ZFYVE16 -0.0565188149022875 0.931710308972254 0.0160524466554293 0.981290006166023 mirMAP -0.109324767341783 0.0121872642924793 NA NA NA hsa-miR-374b-5p ZFYVE16 -0.120825593958128 0.872556407127498 0.0160524466554293 0.981290006166023 mirMAP -0.186735994055013 9.96799953414659e-06 NA NA NA hsa-miR-590-3p ZFYVE16 -0.139003976504018 0.700453857398655 0.0160524466554293 0.981290006166023 miRanda -0.120473023123952 0.000133438569444141 NA NA NA hsa-miR-106a-5p ZFYVE9 -0.187436837607903 0.776596826979526 0.0337431692845689 0.953446481681854 MirTarget;miRNATAP -0.123467025158733 0.000328319720625363 NA NA NA hsa-miR-194-5p ZFYVE9 0.0780179473961882 0.940899924401906 0.0337431692845689 0.953446481681854 MirTarget -0.185031753630134 3.38705999024904e-13 NA NA NA hsa-miR-429 ZFYVE9 -0.202051344131673 0.830298580465583 0.0337431692845689 0.953446481681854 miRNATAP -0.106411673524847 0.00390021553053892 NA NA NA hsa-miR-454-3p ZFYVE9 0.136203543900226 0.745492956399051 0.0337431692845689 0.953446481681854 MirTarget;miRNATAP -0.159966899402511 0.00709347333104225 NA NA NA