miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-105-5p AKT2 -0.567459149851677 8.20858944634795e-06 0.139361896216647 0.0151763675439579 mirMAP -0.11517777162873 2.5456118337521e-14 NA NA NA hsa-miR-146b-5p AKT3 0.441078059667297 0.000237619929889385 -0.235109681312394 0.000861339724103604 miRNAWalker2_validate -0.14853390000962 1.54850741316524e-10 NA NA NA hsa-miR-15a-5p AKT3 0.142658985373611 0.0536219185009004 -0.235109681312394 0.000861339724103604 miRNAWalker2_validate;miRTarBase;miRNATAP -0.171093255137198 0.000104922528677221 NA NA NA hsa-miR-15b-5p AKT3 0.592863156692837 1.41971517354055e-10 -0.235109681312394 0.000861339724103604 miRNATAP -0.149023414077877 1.00397425898265e-06 NA NA NA hsa-miR-28-3p AKT3 0.139444423971018 0.0811187936164314 -0.235109681312394 0.000861339724103604 miRNATAP -0.281326919526608 6.94030005162363e-11 NA NA NA hsa-miR-320a AKT3 0.092135599636725 0.243028758989929 -0.235109681312394 0.000861339724103604 PITA;miRanda;miRNATAP -0.162091233103736 0.000150010109497495 NA NA NA hsa-miR-320c AKT3 0.343259124189966 0.000248338401291051 -0.235109681312394 0.000861339724103604 PITA;miRanda;miRNATAP -0.11345587888064 0.000121683825333423 NA NA NA hsa-miR-362-3p AKT3 0.032375035235532 0.736465332563774 -0.235109681312394 0.000861339724103604 miRanda -0.133145359057788 1.93504628679194e-06 NA NA NA hsa-miR-362-5p AKT3 -0.0730185557229279 0.425572997292224 -0.235109681312394 0.000861339724103604 PITA;TargetScan;miRNATAP -0.12269062278053 4.12753291036148e-05 NA NA NA hsa-miR-501-3p AKT3 0.0726267165568464 0.382729320534971 -0.235109681312394 0.000861339724103604 miRNATAP -0.230986821283872 3.52473505159126e-12 NA NA NA hsa-miR-502-3p AKT3 0.0276791089364088 0.697605011368848 -0.235109681312394 0.000861339724103604 miRNATAP -0.217874003496912 1.14360007951059e-08 NA NA NA hsa-miR-93-5p AKT3 0.139766237971122 0.101057320076629 -0.235109681312394 0.000861339724103604 miRNATAP -0.208262975522215 1.91431764461584e-05 NA NA NA hsa-miR-219a-1-3p ARRB1 0.187632202999477 0.087140243409658 -0.532538735532142 2.69377625979886e-09 MirTarget -0.163159608910206 3.50811905949662e-06 NA NA NA hsa-miR-550a-5p ARRB1 0.446742576641774 3.20431264038718e-06 -0.532538735532142 2.69377625979886e-09 MirTarget -0.212971766702834 7.99358177281406e-08 NA NA NA hsa-miR-92a-3p ARRB1 0.0407239381334659 0.643983393805961 -0.532538735532142 2.69377625979886e-09 miRNAWalker2_validate -0.247096428614713 0.000407272939965658 NA NA NA hsa-miR-15a-5p ATF2 0.142658985373611 0.0536219185009004 -0.0726138691955862 0.33392541656757 miRNAWalker2_validate -0.144652702403681 0.0041247080050325 NA NA NA hsa-miR-19a-3p ATF2 0.0466707843731911 0.576818938277755 -0.0726138691955862 0.33392541656757 MirTarget;miRNATAP -0.127370853754012 0.000958008133873 NA NA NA hsa-miR-19b-3p ATF2 -0.0138427450847924 0.856506310673067 -0.0726138691955862 0.33392541656757 miRNAWalker2_validate;MirTarget;miRNATAP -0.172670973704451 0.000168434540469046 NA NA NA hsa-miR-26b-5p ATF2 -0.0984536538762768 0.231803769574623 -0.0726138691955862 0.33392541656757 MirTarget;miRNATAP -0.164082559964853 0.000243149817199337 21901137 Coordinated regulation of ATF2 by miR 26b in γ irradiated lung cancer cells; Concurrent analysis of time-series mRNA and microRNA profiles uncovered that expression of miR-26b was down regulated and its target activating transcription factor 2 ATF2 mRNA was up regulated in γ-irradiated H1299 cells; IR in miR-26b overexpressed H1299 cells could not induce expression of ATF2; From these results we concluded that IR-induced up-regulation of ATF2 was coordinately enhanced by suppression of miR-26b in lung cancer cells which may enhance the effect of IR in the MAPK signaling pathway lung cancer hsa-miR-30a-5p ATF2 -0.062942936611238 0.513851954700252 -0.0726138691955862 0.33392541656757 mirMAP -0.16690467064425 0.00156810646595739 NA NA NA hsa-miR-30b-5p ATF2 -0.0858101016322106 0.263243418521854 -0.0726138691955862 0.33392541656757 mirMAP -0.188763555453189 9.29345111461018e-05 NA NA NA hsa-miR-30c-5p ATF2 -0.0469114469943097 0.565934557464627 -0.0726138691955862 0.33392541656757 mirMAP -0.262852827602014 4.81664922337019e-08 NA NA NA hsa-miR-320a ATF2 0.092135599636725 0.243028758989929 -0.0726138691955862 0.33392541656757 miRanda -0.135329118151361 0.00562986282916445 NA NA NA hsa-miR-3065-3p BDNF -0.261348288537884 0.0343753235107924 0.163817385359977 0.296772674802745 MirTarget;miRNATAP -0.263514713378115 5.47125066901657e-06 NA NA NA hsa-miR-3065-5p BDNF -0.262608140481507 0.0414570974148034 0.163817385359977 0.296772674802745 mirMAP;miRNATAP -0.276290459467715 1.96100180067284e-07 NA NA NA hsa-miR-16-2-3p CACNA1A 0.468816222075619 7.04377763166292e-05 -0.264660859430472 0.0116309386856197 mirMAP -0.15113198186385 4.83350827912584e-05 NA NA NA hsa-miR-2355-3p CACNA1A 0.186207523505296 0.0525918026993012 -0.264660859430472 0.0116309386856197 MirTarget;miRNATAP -0.26208928503175 9.28305113355271e-09 NA NA NA hsa-miR-27a-3p CACNA1A 0.303760032895792 0.00457375391189806 -0.264660859430472 0.0116309386856197 MirTarget -0.400611637191952 2.38683645689109e-20 NA NA NA hsa-miR-27b-3p CACNA1A -0.0599187745243146 0.58208143475992 -0.264660859430472 0.0116309386856197 MirTarget -0.188793689043985 2.7567593527162e-05 NA NA NA hsa-miR-339-5p CACNA1A 0.273253751377152 0.0185300170790638 -0.264660859430472 0.0116309386856197 mirMAP -0.311686675722644 6.03005368339996e-17 NA NA NA hsa-miR-590-3p CACNA1A 0.312951515438396 0.000480455423843996 -0.264660859430472 0.0116309386856197 miRanda -0.326941048877797 2.0396760091937e-11 NA NA NA hsa-miR-629-3p CACNA1A 0.318874955109265 0.00062631284800046 -0.264660859430472 0.0116309386856197 MirTarget;miRNATAP -0.233802334738201 8.40104559195587e-07 NA NA NA hsa-miR-320a CACNA1B 0.092135599636725 0.243028758989929 -1.01073747194827 1.61454834484044e-07 miRanda -0.774138035826735 7.04833860258727e-09 NA NA NA hsa-miR-320b CACNA1B 0.283477746304177 0.0005953763020907 -1.01073747194827 1.61454834484044e-07 miRanda -0.523614227277927 2.97516022441419e-07 NA NA NA hsa-miR-320c CACNA1B 0.343259124189966 0.000248338401291051 -1.01073747194827 1.61454834484044e-07 miRanda -0.443215847162415 1.79611101335203e-06 NA NA NA hsa-miR-362-3p CACNA1B 0.032375035235532 0.736465332563774 -1.01073747194827 1.61454834484044e-07 MirTarget;miRNATAP -0.343676358979497 0.000104690125563795 NA NA NA hsa-miR-450b-5p CACNA1B 0.270544879013992 0.00801537838499562 -1.01073747194827 1.61454834484044e-07 MirTarget;miRNATAP -0.442595452057808 1.40331775790039e-07 NA NA NA hsa-miR-590-3p CACNA1B 0.312951515438396 0.000480455423843996 -1.01073747194827 1.61454834484044e-07 miRanda -0.371127835679309 8.95153398126168e-05 NA NA NA hsa-miR-186-5p CACNA1C 0.0606381894130505 0.514217717592464 -0.215686399630776 0.00925694548036067 mirMAP -0.133668350967985 0.00123851117338937 NA NA NA hsa-miR-26b-5p CACNA1C -0.0984536538762768 0.231803769574623 -0.215686399630776 0.00925694548036067 MirTarget;miRNATAP -0.14784905288033 0.00361104109146085 NA NA NA hsa-miR-30a-5p CACNA1C -0.062942936611238 0.513851954700252 -0.215686399630776 0.00925694548036067 mirMAP -0.229962648630938 0.000116926824924672 NA NA NA hsa-miR-30c-5p CACNA1C -0.0469114469943097 0.565934557464627 -0.215686399630776 0.00925694548036067 mirMAP -0.21528935996168 8.95538710479734e-05 NA NA NA hsa-miR-320a CACNA1C 0.092135599636725 0.243028758989929 -0.215686399630776 0.00925694548036067 miRNATAP -0.226802745474606 3.92360864026878e-05 NA NA NA hsa-miR-320b CACNA1C 0.283477746304177 0.0005953763020907 -0.215686399630776 0.00925694548036067 miRNATAP -0.116066715859627 0.0059394631481825 NA NA NA hsa-miR-320c CACNA1C 0.343259124189966 0.000248338401291051 -0.215686399630776 0.00925694548036067 miRNATAP -0.20626050059033 5.11793112271948e-08 NA NA NA hsa-let-7a-2-3p CACNA1D 0.295235553592458 0.00290654476250609 -0.318103447753506 0.000652991130948403 MirTarget -0.120737805072999 0.00342803803183094 NA NA NA hsa-let-7i-5p CACNA1D 0.0952853587923244 0.192120688957249 -0.318103447753506 0.000652991130948403 miRNATAP -0.269815867987708 0.000120962668499103 NA NA NA hsa-miR-135a-5p CACNA1D -0.122734612943241 0.196985964641886 -0.318103447753506 0.000652991130948403 MirTarget -0.144243581259508 0.001009084235893 NA NA NA hsa-miR-30c-5p CACNA1D -0.0469114469943097 0.565934557464627 -0.318103447753506 0.000652991130948403 miRNATAP -0.374281663381514 2.72158130331297e-09 NA NA NA hsa-miR-362-3p CACNA1D 0.032375035235532 0.736465332563774 -0.318103447753506 0.000652991130948403 miRanda -0.16787075375391 6.1456692237058e-05 NA NA NA hsa-miR-590-3p CACNA1D 0.312951515438396 0.000480455423843996 -0.318103447753506 0.000652991130948403 miRanda;miRNATAP -0.239293831219549 7.74169900150185e-08 NA NA NA hsa-miR-629-5p CACNA1D 0.100422082714475 0.214291160007531 -0.318103447753506 0.000652991130948403 MirTarget -0.299553963030017 2.45726177804353e-08 NA NA NA hsa-let-7a-2-3p CACNA1E 0.295235553592458 0.00290654476250609 -0.569847771875012 9.69601679094844e-05 mirMAP -0.287063862993946 1.03599853519214e-05 NA NA NA hsa-let-7e-5p CACNA1E 0.0471189209570344 0.657255455444655 -0.569847771875012 9.69601679094844e-05 miRNATAP -0.216929662389206 0.00224167794148438 NA NA NA hsa-let-7i-5p CACNA1E 0.0952853587923244 0.192120688957249 -0.569847771875012 9.69601679094844e-05 miRNATAP -0.683583147924187 5.30441139033797e-10 NA NA NA hsa-miR-106b-5p CACNA1E 0.167096183547615 0.0497544396383451 -0.569847771875012 9.69601679094844e-05 mirMAP -0.314181252128203 0.000218911163229139 NA NA NA hsa-miR-125a-5p CACNA1E -0.0833349424517387 0.325440200253607 -0.569847771875012 9.69601679094844e-05 miRanda -0.25326558543168 0.00660918419810706 NA NA NA hsa-miR-1266-5p CACNA1E 0.313515127917259 0.0138664194727392 -0.569847771875012 9.69601679094844e-05 MirTarget -0.13832531085934 0.00618319796088083 NA NA NA hsa-miR-1271-5p CACNA1E 0.101224150198862 0.215169362708611 -0.569847771875012 9.69601679094844e-05 mirMAP -0.206511864416747 0.00962322879946216 NA NA NA hsa-miR-130b-5p CACNA1E 0.413070888963592 1.98866876365509e-06 -0.569847771875012 9.69601679094844e-05 miRNATAP -0.25972362720508 0.000608442089189108 NA NA NA hsa-miR-141-3p CACNA1E 0.41120561991992 0.000393344390969055 -0.569847771875012 9.69601679094844e-05 MirTarget;TargetScan;miRNATAP -0.168253988146395 0.00268140052705055 NA NA NA hsa-miR-142-3p CACNA1E 0.558908907203977 1.37828834702416e-05 -0.569847771875012 9.69601679094844e-05 miRanda -0.213331274653768 2.804988411466e-05 NA NA NA hsa-miR-142-5p CACNA1E 0.434884875454107 0.000575570345702788 -0.569847771875012 9.69601679094844e-05 MirTarget;mirMAP -0.24116103994413 1.38920607167175e-06 NA NA NA hsa-miR-148a-3p CACNA1E 0.306821592493439 0.0392356958885949 -0.569847771875012 9.69601679094844e-05 mirMAP -0.167652351960226 0.000207832248744817 NA NA NA hsa-miR-148b-5p CACNA1E 0.127111784487801 0.188731110216917 -0.569847771875012 9.69601679094844e-05 mirMAP -0.226726875696991 0.000722024568429348 NA NA NA hsa-miR-15a-5p CACNA1E 0.142658985373611 0.0536219185009004 -0.569847771875012 9.69601679094844e-05 MirTarget -0.401567229323789 0.000121089223665663 NA NA NA hsa-miR-15b-5p CACNA1E 0.592863156692837 1.41971517354055e-10 -0.569847771875012 9.69601679094844e-05 MirTarget -0.406003981601107 1.62327506079856e-08 NA NA NA hsa-miR-16-2-3p CACNA1E 0.468816222075619 7.04377763166292e-05 -0.569847771875012 9.69601679094844e-05 mirMAP -0.151237156865141 0.0048394989937493 NA NA NA hsa-miR-16-5p CACNA1E 0.246024668671282 0.00346042804503716 -0.569847771875012 9.69601679094844e-05 MirTarget -0.315570606736949 0.000434791502181832 NA NA NA hsa-miR-17-5p CACNA1E 0.0975751369167082 0.20621110214601 -0.569847771875012 9.69601679094844e-05 mirMAP -0.379941418688685 0.00021692220337652 NA NA NA hsa-miR-186-5p CACNA1E 0.0606381894130505 0.514217717592464 -0.569847771875012 9.69601679094844e-05 mirMAP -0.423872277345216 1.66972742898617e-08 NA NA NA hsa-miR-195-3p CACNA1E 0.100105455903079 0.133362389112338 -0.569847771875012 9.69601679094844e-05 mirMAP -0.51126717527416 1.8439995092908e-07 NA NA NA hsa-miR-19a-3p CACNA1E 0.0466707843731911 0.576818938277755 -0.569847771875012 9.69601679094844e-05 mirMAP -0.21200782890506 0.00828230504034734 NA NA NA hsa-miR-19b-3p CACNA1E -0.0138427450847924 0.856506310673067 -0.569847771875012 9.69601679094844e-05 mirMAP -0.246626989293808 0.0099777608695719 NA NA NA hsa-miR-21-5p CACNA1E 1.0504925175311 2.58081295984106e-11 -0.569847771875012 9.69601679094844e-05 mirMAP -0.451889095936332 3.2593879420763e-25 NA NA NA hsa-miR-28-5p CACNA1E 0.104003572105781 0.153594705579534 -0.569847771875012 9.69601679094844e-05 mirMAP -0.453941553960938 1.39026685216558e-06 NA NA NA hsa-miR-3065-3p CACNA1E -0.261348288537884 0.0343753235107924 -0.569847771875012 9.69601679094844e-05 MirTarget;miRNATAP -0.184510873255171 0.000655380617208557 NA NA NA hsa-miR-3065-5p CACNA1E -0.262608140481507 0.0414570974148034 -0.569847771875012 9.69601679094844e-05 mirMAP -0.211752654453755 1.95893887942518e-05 NA NA NA hsa-miR-30a-3p CACNA1E 0.0655410309550977 0.509541256241954 -0.569847771875012 9.69601679094844e-05 MirTarget;mirMAP;miRNATAP -0.312209053564724 0.000194472078194612 NA NA NA hsa-miR-30d-3p CACNA1E 0.0854049347792898 0.20691254801121 -0.569847771875012 9.69601679094844e-05 MirTarget;mirMAP;miRNATAP -0.266218836446433 0.00532856101391993 NA NA NA hsa-miR-30e-3p CACNA1E 0.00173769765874887 0.984965501547409 -0.569847771875012 9.69601679094844e-05 MirTarget;mirMAP;miRNATAP -0.311468848846731 0.00102794675931936 NA NA NA hsa-miR-3127-5p CACNA1E -0.0645479321229978 0.382330591204685 -0.569847771875012 9.69601679094844e-05 MirTarget -0.238042388182824 0.00673085440749334 NA NA NA hsa-miR-320a CACNA1E 0.092135599636725 0.243028758989929 -0.569847771875012 9.69601679094844e-05 miRanda;miRNATAP -0.443542288672664 1.12948813993509e-05 NA NA NA hsa-miR-320b CACNA1E 0.283477746304177 0.0005953763020907 -0.569847771875012 9.69601679094844e-05 miRanda;miRNATAP -0.368641431122113 1.57993697323939e-06 NA NA NA hsa-miR-320c CACNA1E 0.343259124189966 0.000248338401291051 -0.569847771875012 9.69601679094844e-05 miRanda;miRNATAP -0.350768101709383 4.60203419189168e-07 NA NA NA hsa-miR-374a-3p CACNA1E 0.176226170437625 0.0343958848425446 -0.569847771875012 9.69601679094844e-05 mirMAP -0.511238407595226 7.39526818186029e-08 NA NA NA hsa-miR-374a-5p CACNA1E 0.0121037060909277 0.865417963345881 -0.569847771875012 9.69601679094844e-05 mirMAP -0.321642877508947 0.000873806066982522 NA NA NA hsa-miR-421 CACNA1E -0.171573235029879 0.0518112933651029 -0.569847771875012 9.69601679094844e-05 mirMAP -0.207353918884904 0.00442941171560841 NA NA NA hsa-miR-452-5p CACNA1E 0.599327068454211 1.02031931068531e-05 -0.569847771875012 9.69601679094844e-05 mirMAP -0.369628629002967 3.8048786417053e-16 NA NA NA hsa-miR-502-3p CACNA1E 0.0276791089364088 0.697605011368848 -0.569847771875012 9.69601679094844e-05 miRNATAP -0.307308129350793 0.000763772883406498 NA NA NA hsa-miR-505-3p CACNA1E 0.115486008167472 0.109833720698312 -0.569847771875012 9.69601679094844e-05 mirMAP -0.471978633519725 3.80076787498887e-07 NA NA NA hsa-miR-505-5p CACNA1E 0.0973008785018434 0.183209581426791 -0.569847771875012 9.69601679094844e-05 mirMAP -0.309943365557148 0.000475085639919054 NA NA NA hsa-miR-548b-3p CACNA1E 0.340474544210108 0.00224491592019745 -0.569847771875012 9.69601679094844e-05 mirMAP;miRNATAP -0.162511476052081 0.0051669515118279 NA NA NA hsa-miR-550a-3p CACNA1E 0.311518294008363 0.0015285640451888 -0.569847771875012 9.69601679094844e-05 mirMAP -0.23518896433972 0.000283737985694508 NA NA NA hsa-miR-589-3p CACNA1E 0.00739371736361305 0.927768051649329 -0.569847771875012 9.69601679094844e-05 mirMAP -0.295562299834388 0.000186700797499734 NA NA NA hsa-miR-590-3p CACNA1E 0.312951515438396 0.000480455423843996 -0.569847771875012 9.69601679094844e-05 miRanda -0.40137141736604 1.25987141104387e-08 NA NA NA hsa-miR-590-5p CACNA1E 0.16946027035949 0.0386004382081678 -0.569847771875012 9.69601679094844e-05 miRanda;mirMAP -0.367311213541456 2.91464229846951e-06 NA NA NA hsa-miR-629-3p CACNA1E 0.318874955109265 0.00062631284800046 -0.569847771875012 9.69601679094844e-05 miRNATAP -0.356941391091919 1.60734779453386e-07 NA NA NA hsa-miR-708-5p CACNA1E -0.00936519718301376 0.919857671524527 -0.569847771875012 9.69601679094844e-05 mirMAP -0.326376293472769 1.24885736417146e-05 NA NA NA hsa-miR-93-5p CACNA1E 0.139766237971122 0.101057320076629 -0.569847771875012 9.69601679094844e-05 mirMAP -0.473089603913452 4.1762044775939e-05 NA NA NA hsa-miR-942-5p CACNA1E 0.331570745524138 0.00475398014468334 -0.569847771875012 9.69601679094844e-05 MirTarget -0.194333606958141 0.000413509679342321 NA NA NA hsa-miR-362-5p CACNA1G -0.0730185557229279 0.425572997292224 0.0497012637860128 0.752227985089196 miRNATAP -0.201238878146508 0.00882155561024552 NA NA NA hsa-miR-629-3p CACNA1G 0.318874955109265 0.00062631284800046 0.0497012637860128 0.752227985089196 MirTarget -0.369422262189409 5.18365457499077e-07 NA NA NA hsa-miR-32-5p CACNA1H 0.130313603388223 0.177843055266148 -0.194831003561515 0.095432932168481 miRNATAP -0.15486723944751 0.00337968752812693 NA NA NA hsa-let-7i-5p CACNA1I 0.0952853587923244 0.192120688957249 -0.665635392267387 5.98624819523935e-05 miRNATAP -0.750278318570171 2.58249786836278e-09 NA NA NA hsa-miR-1226-3p CACNA1I -0.098618802853881 0.346683714981524 -0.665635392267387 5.98624819523935e-05 mirMAP -0.195968499067077 0.00514885228714785 NA NA NA hsa-miR-141-3p CACNA1I 0.41120561991992 0.000393344390969055 -0.665635392267387 5.98624819523935e-05 TargetScan -0.2335719281149 0.000257380760476097 NA NA NA hsa-miR-148a-3p CACNA1I 0.306821592493439 0.0392356958885949 -0.665635392267387 5.98624819523935e-05 mirMAP -0.234680430187367 5.1327228160367e-06 NA NA NA hsa-miR-186-5p CACNA1I 0.0606381894130505 0.514217717592464 -0.665635392267387 5.98624819523935e-05 mirMAP -0.557769763860844 6.48903958588102e-11 NA NA NA hsa-miR-18a-5p CACNA1I 0.175320895022849 0.0732549187136286 -0.665635392267387 5.98624819523935e-05 mirMAP -0.19215189731936 0.00994653429424181 NA NA NA hsa-miR-25-3p CACNA1I 0.316649850160985 0.000777982468387578 -0.665635392267387 5.98624819523935e-05 MirTarget;miRNATAP -0.431379619351818 1.96377005273044e-05 NA NA NA hsa-miR-3065-3p CACNA1I -0.261348288537884 0.0343753235107924 -0.665635392267387 5.98624819523935e-05 mirMAP -0.363869140612985 2.71877092748618e-09 NA NA NA hsa-miR-30c-2-3p CACNA1I -0.18630560418806 0.0313113706136533 -0.665635392267387 5.98624819523935e-05 mirMAP -0.268263286130031 0.0035998603138928 NA NA NA hsa-miR-32-5p CACNA1I 0.130313603388223 0.177843055266148 -0.665635392267387 5.98624819523935e-05 MirTarget;miRNATAP -0.317922164986639 3.42137523617692e-05 NA NA NA hsa-miR-320c CACNA1I 0.343259124189966 0.000248338401291051 -0.665635392267387 5.98624819523935e-05 mirMAP -0.498756713172729 2.65687414635993e-10 NA NA NA hsa-miR-532-3p CACNA1I 0.150624483952741 0.0599635132177191 -0.665635392267387 5.98624819523935e-05 mirMAP -0.335285346459051 0.000392232079987494 NA NA NA hsa-miR-92a-1-5p CACNA1I 0.32438915788874 0.00126041292142611 -0.665635392267387 5.98624819523935e-05 mirMAP -0.215876576399129 0.00368290105363334 NA NA NA hsa-miR-92b-3p CACNA1I -0.213968504161963 0.0523921855715716 -0.665635392267387 5.98624819523935e-05 MirTarget;miRNATAP -0.457376645274887 1.94267821251552e-09 NA NA NA hsa-miR-141-3p CACNA2D1 0.41120561991992 0.000393344390969055 -0.733660858522097 0.000112625651147851 TargetScan -0.338291339986102 3.43678759652239e-06 NA NA NA hsa-miR-155-5p CACNA2D1 0.969837380981085 5.86551495710056e-15 -0.733660858522097 0.000112625651147851 mirMAP -0.418684493830041 9.01691868551659e-11 NA NA NA hsa-miR-195-3p CACNA2D1 0.100105455903079 0.133362389112338 -0.733660858522097 0.000112625651147851 mirMAP -0.366086237576728 0.00466981964351407 NA NA NA hsa-miR-200b-3p CACNA2D1 0.245768526504511 0.0580744465744737 -0.733660858522097 0.000112625651147851 TargetScan -0.2171460219793 0.000944636825066568 NA NA NA hsa-miR-21-3p CACNA2D1 1.3484283943822 2.0036022227401e-17 -0.733660858522097 0.000112625651147851 mirMAP -0.262819515199238 3.32707423709541e-07 NA NA NA hsa-miR-23a-3p CACNA2D1 0.334693010651106 0.00144448147063433 -0.733660858522097 0.000112625651147851 mirMAP -0.295219483309951 0.00111631443947263 NA NA NA hsa-miR-26b-5p CACNA2D1 -0.0984536538762768 0.231803769574623 -0.733660858522097 0.000112625651147851 mirMAP -0.42545814279481 0.000467384034391381 NA NA NA hsa-miR-3065-5p CACNA2D1 -0.262608140481507 0.0414570974148034 -0.733660858522097 0.000112625651147851 mirMAP -0.182714488811725 0.00506270874571639 NA NA NA hsa-miR-576-5p CACNA2D1 0.106482276040047 0.194379152564166 -0.733660858522097 0.000112625651147851 mirMAP -0.517420219745777 4.61927697929107e-07 NA NA NA hsa-miR-590-3p CACNA2D1 0.312951515438396 0.000480455423843996 -0.733660858522097 0.000112625651147851 mirMAP -0.387062380021504 3.08846177128652e-05 NA NA NA hsa-miR-10a-5p CACNA2D2 1.10332501906319 5.3831631561183e-08 -0.735983720754496 9.24689385558017e-11 mirMAP -0.188796147360268 1.73182426593616e-15 NA NA NA hsa-miR-10b-5p CACNA2D2 1.54586540986745 2.64595843546465e-08 -0.735983720754496 9.24689385558017e-11 mirMAP -0.118213843777217 1.96403674484934e-11 NA NA NA hsa-miR-1271-5p CACNA2D2 0.101224150198862 0.215169362708611 -0.735983720754496 9.24689385558017e-11 MirTarget -0.181106355841943 0.00356404794371917 NA NA NA hsa-miR-142-3p CACNA2D2 0.558908907203977 1.37828834702416e-05 -0.735983720754496 9.24689385558017e-11 miRanda -0.312808080866303 7.98318309871326e-16 NA NA NA hsa-miR-193a-3p CACNA2D2 0.395602305834739 0.00182611787714301 -0.735983720754496 9.24689385558017e-11 miRanda -0.255007155009259 1.04689163657272e-10 NA NA NA hsa-miR-22-5p CACNA2D2 0.0437233965539527 0.639996108995995 -0.735983720754496 9.24689385558017e-11 mirMAP -0.252463841114385 2.75250754291164e-06 NA NA NA hsa-miR-3065-5p CACNA2D2 -0.262608140481507 0.0414570974148034 -0.735983720754496 9.24689385558017e-11 MirTarget;miRNATAP -0.113999487377551 0.0033428601954506 NA NA NA hsa-miR-34a-5p CACNA2D2 0.143472919835524 0.211283228567057 -0.735983720754496 9.24689385558017e-11 mirMAP -0.183572179828064 3.54884015173903e-05 NA NA NA hsa-miR-362-3p CACNA2D2 0.032375035235532 0.736465332563774 -0.735983720754496 9.24689385558017e-11 miRanda -0.188242704011023 0.000285485165644531 NA NA NA hsa-miR-3622a-3p CACNA2D2 0.0389203848593471 0.75605812962459 -0.735983720754496 9.24689385558017e-11 miRNATAP -0.121235634443843 0.00284988877146901 NA NA NA hsa-miR-423-5p CACNA2D2 0.0965587900813789 0.148039180704338 -0.735983720754496 9.24689385558017e-11 MirTarget;miRNATAP -0.421078005974876 4.80691122670401e-07 NA NA NA hsa-miR-455-3p CACNA2D2 0.512701816402104 0.000459755983280155 -0.735983720754496 9.24689385558017e-11 PITA;miRNATAP -0.228342126089409 1.26727233047609e-11 NA NA NA hsa-miR-590-3p CACNA2D2 0.312951515438396 0.000480455423843996 -0.735983720754496 9.24689385558017e-11 miRanda -0.462404564611665 1.01081267952547e-17 NA NA NA hsa-miR-193a-3p CACNA2D3 0.395602305834739 0.00182611787714301 -0.868057164513033 4.98248654470456e-07 miRanda -0.24562249868962 6.11969631566437e-05 NA NA NA hsa-miR-27a-3p CACNA2D3 0.303760032895792 0.00457375391189806 -0.868057164513033 4.98248654470456e-07 miRNATAP -0.467426593983671 8.49203702048347e-10 NA NA NA hsa-miR-28-5p CACNA2D3 0.104003572105781 0.153594705579534 -0.868057164513033 4.98248654470456e-07 miRanda -0.299343821064918 0.00827136657771151 NA NA NA hsa-miR-590-3p CACNA2D3 0.312951515438396 0.000480455423843996 -0.868057164513033 4.98248654470456e-07 miRanda -0.47152484190071 2.29838498085208e-08 NA NA NA hsa-miR-129-5p CACNA2D4 -0.567133990117126 0.00116152215679936 0.124667249111744 0.223762782279162 miRanda;mirMAP -0.155084059913391 2.17295374821659e-09 NA NA NA hsa-miR-335-3p CACNA2D4 0.34540584335595 0.00043848660222294 0.124667249111744 0.223762782279162 mirMAP -0.126967474609104 0.00740281571496252 NA NA NA hsa-miR-186-5p CACNB1 0.0606381894130505 0.514217717592464 -0.311761551083767 0.000431381089954008 miRNAWalker2_validate;mirMAP -0.12291986229546 0.00587671408246285 NA NA NA hsa-miR-296-5p CACNB1 -0.0192165981442809 0.870822664524408 -0.311761551083767 0.000431381089954008 miRNATAP -0.101323091156805 0.00147168238535782 NA NA NA hsa-miR-320a CACNB1 0.092135599636725 0.243028758989929 -0.311761551083767 0.000431381089954008 miRanda -0.268544015184734 5.92012804277746e-06 NA NA NA hsa-miR-320b CACNB1 0.283477746304177 0.0005953763020907 -0.311761551083767 0.000431381089954008 miRanda -0.216072278799377 1.65811221319678e-06 NA NA NA hsa-miR-320c CACNB1 0.343259124189966 0.000248338401291051 -0.311761551083767 0.000431381089954008 miRanda -0.247985708650015 1.03536033122606e-09 NA NA NA hsa-miR-423-5p CACNB1 0.0965587900813789 0.148039180704338 -0.311761551083767 0.000431381089954008 PITA;miRNATAP -0.1674884793358 0.00840549778260898 NA NA NA hsa-miR-424-5p CACNB1 0.25140374049676 0.00709934939774983 -0.311761551083767 0.000431381089954008 miRNATAP -0.187758508990278 7.38863151677189e-06 NA NA NA hsa-miR-497-5p CACNB1 -0.000783764887886562 0.991703566618871 -0.311761551083767 0.000431381089954008 miRNATAP -0.140772260191807 0.00872911293873225 NA NA NA hsa-miR-576-5p CACNB1 0.106482276040047 0.194379152564166 -0.311761551083767 0.000431381089954008 PITA;mirMAP -0.210230314559371 5.3289331018115e-06 NA NA NA hsa-miR-629-3p CACNB3 0.318874955109265 0.00062631284800046 -0.0461664948047993 0.627133922595265 miRNATAP -0.144514854833126 0.000903222267330802 NA NA NA hsa-let-7i-5p CACNB4 0.0952853587923244 0.192120688957249 -0.27209352233585 0.000720553059809518 miRNATAP -0.227829445928731 0.000127976432248883 NA NA NA hsa-miR-155-5p CACNB4 0.969837380981085 5.86551495710056e-15 -0.27209352233585 0.000720553059809518 mirMAP;miRNATAP -0.103361422915879 0.000109828536374762 NA NA NA hsa-miR-15b-5p CACNB4 0.592863156692837 1.41971517354055e-10 -0.27209352233585 0.000720553059809518 miRNATAP -0.148154231807729 0.000130099529665484 NA NA NA hsa-miR-20a-3p CACNB4 0.102743778777997 0.19677865359751 -0.27209352233585 0.000720553059809518 miRNATAP -0.254243900256485 3.28984403334107e-09 NA NA NA hsa-miR-25-3p CACNB4 0.316649850160985 0.000777982468387578 -0.27209352233585 0.000720553059809518 mirMAP -0.170584115278068 0.000316411793739376 NA NA NA hsa-miR-26a-2-3p CACNB4 0.26597501648608 0.000796444054340143 -0.27209352233585 0.000720553059809518 mirMAP -0.15292622671142 0.000380140160657356 NA NA NA hsa-miR-26b-5p CACNB4 -0.0984536538762768 0.231803769574623 -0.27209352233585 0.000720553059809518 miRNAWalker2_validate;miRNATAP -0.207716988101455 2.76293301613475e-05 NA NA NA hsa-miR-3065-5p CACNB4 -0.262608140481507 0.0414570974148034 -0.27209352233585 0.000720553059809518 mirMAP -0.211785492921778 2.88340206437876e-16 NA NA NA hsa-miR-32-5p CACNB4 0.130313603388223 0.177843055266148 -0.27209352233585 0.000720553059809518 mirMAP -0.115648352500491 0.00131293924304938 NA NA NA hsa-miR-320a CACNB4 0.092135599636725 0.243028758989929 -0.27209352233585 0.000720553059809518 PITA;miRanda -0.325755066320839 1.15063682561362e-09 NA NA NA hsa-miR-320b CACNB4 0.283477746304177 0.0005953763020907 -0.27209352233585 0.000720553059809518 PITA;miRanda -0.155161765486779 0.000165642795253261 NA NA NA hsa-miR-320c CACNB4 0.343259124189966 0.000248338401291051 -0.27209352233585 0.000720553059809518 PITA;miRanda -0.238877895941348 9.31333115629121e-11 NA NA NA hsa-miR-374a-5p CACNB4 0.0121037060909277 0.865417963345881 -0.27209352233585 0.000720553059809518 mirMAP -0.20676210137123 5.96230282955754e-05 NA NA NA hsa-miR-374b-5p CACNB4 -0.210113949579608 0.0056866083818614 -0.27209352233585 0.000720553059809518 mirMAP;miRNATAP -0.157148892833371 0.00207599024116164 NA NA NA hsa-miR-421 CACNB4 -0.171573235029879 0.0518112933651029 -0.27209352233585 0.000720553059809518 PITA;miRanda;miRNATAP -0.116646545717563 0.00271920440747147 NA NA NA hsa-miR-424-5p CACNB4 0.25140374049676 0.00709934939774983 -0.27209352233585 0.000720553059809518 miRNATAP -0.11985589287255 0.00174881886835915 NA NA NA hsa-miR-505-3p CACNB4 0.115486008167472 0.109833720698312 -0.27209352233585 0.000720553059809518 miRNATAP -0.289947811624807 4.52972445004963e-09 NA NA NA hsa-miR-589-3p CACNB4 0.00739371736361305 0.927768051649329 -0.27209352233585 0.000720553059809518 mirMAP -0.115159526415828 0.00660003613687416 NA NA NA hsa-miR-590-3p CACNB4 0.312951515438396 0.000480455423843996 -0.27209352233585 0.000720553059809518 miRanda;mirMAP;miRNATAP -0.203211576469727 7.24919631336676e-08 NA NA NA hsa-miR-708-3p CACNB4 0.00458267260363954 0.962455132950708 -0.27209352233585 0.000720553059809518 mirMAP -0.116780818844558 0.00292332251724492 NA NA NA hsa-miR-92b-3p CACNB4 -0.213968504161963 0.0523921855715716 -0.27209352233585 0.000720553059809518 mirMAP -0.136492602753719 0.000149390624844348 NA NA NA hsa-miR-361-5p CACNG1 0.0107519600643302 0.882230614095565 -0.0840260002975215 0.508076732774902 miRanda;miRNATAP -0.596704961117502 2.01077004719707e-10 NA NA NA hsa-miR-491-5p CACNG1 -0.749881113074983 8.22859263179194e-09 -0.0840260002975215 0.508076732774902 miRanda -0.243837201246467 3.65306603656867e-09 NA NA NA hsa-miR-590-5p CACNG1 0.16946027035949 0.0386004382081678 -0.0840260002975215 0.508076732774902 miRanda -0.540890162076681 5.97658682176689e-16 NA NA NA hsa-miR-671-5p CACNG1 0.379677704170736 0.000129391032677459 -0.0840260002975215 0.508076732774902 miRNATAP -0.339743946749814 5.46401858398611e-10 NA NA NA hsa-let-7e-5p CACNG4 0.0471189209570344 0.657255455444655 -0.0565977417867947 0.65730562864161 miRNATAP -0.611645749960716 8.6847844111193e-28 NA NA NA hsa-let-7f-1-3p CACNG4 0.110713086694053 0.21484524300518 -0.0565977417867947 0.65730562864161 MirTarget -0.340130097442739 7.12386057933423e-09 NA NA NA hsa-let-7i-5p CACNG4 0.0952853587923244 0.192120688957249 -0.0565977417867947 0.65730562864161 miRNATAP -0.935624649229503 3.19882498957856e-26 NA NA NA hsa-miR-185-3p CACNG4 -0.133219014400353 0.255713818728239 -0.0565977417867947 0.65730562864161 mirMAP -0.239184534020775 9.61537410305285e-08 NA NA NA hsa-miR-186-5p CACNG4 0.0606381894130505 0.514217717592464 -0.0565977417867947 0.65730562864161 mirMAP -0.757144126216249 3.36528091009973e-38 NA NA NA hsa-miR-18a-5p CACNG4 0.175320895022849 0.0732549187136286 -0.0565977417867947 0.65730562864161 mirMAP -0.212370941769595 8.2540733553388e-05 NA NA NA hsa-miR-199a-3p CACNG4 0.41226331871076 0.000497136154474528 -0.0565977417867947 0.65730562864161 PITA -0.323469782060915 3.6057417876552e-13 NA NA NA hsa-miR-199b-3p CACNG4 0.411848361704393 0.000517815011892379 -0.0565977417867947 0.65730562864161 PITA -0.321718458921028 4.31022835928699e-13 NA NA NA hsa-miR-28-5p CACNG4 0.104003572105781 0.153594705579534 -0.0565977417867947 0.65730562864161 miRanda -0.622627437371402 4.12301059057372e-16 NA NA NA hsa-miR-29a-3p CACNG4 -0.224140851576083 0.0349516103550236 -0.0565977417867947 0.65730562864161 miRNATAP -0.379092327574878 4.20582561277224e-09 NA NA NA hsa-miR-29b-3p CACNG4 -0.178522712044497 0.0856106432165465 -0.0565977417867947 0.65730562864161 miRNATAP -0.503912045246371 8.66194514969124e-20 NA NA NA hsa-miR-29c-3p CACNG4 -0.372180390387259 0.00202634431973208 -0.0565977417867947 0.65730562864161 miRNATAP -0.393931614003852 5.69501923474238e-17 NA NA NA hsa-miR-3127-5p CACNG4 -0.0645479321229978 0.382330591204685 -0.0565977417867947 0.65730562864161 mirMAP -0.699457822484834 1.2798221544166e-23 NA NA NA hsa-miR-330-3p CACNG4 -0.427388106938151 0.00300489284414266 -0.0565977417867947 0.65730562864161 mirMAP -0.190990009831805 1.45198655589652e-07 NA NA NA hsa-miR-34c-5p CACNG4 0.181931113688093 0.257266965617363 -0.0565977417867947 0.65730562864161 miRanda -0.147339304233426 6.07490604631997e-06 NA NA NA hsa-miR-375 CACNG4 -0.0268401141324031 0.858358101444697 -0.0565977417867947 0.65730562864161 miRanda -0.284125321451067 8.82948241118991e-17 NA NA NA hsa-miR-425-3p CACNG4 -0.173302979693293 0.0801548384038174 -0.0565977417867947 0.65730562864161 mirMAP -0.45905632171106 1.88987623289699e-18 NA NA NA hsa-miR-432-5p CACNG4 -0.214242438141977 0.166186087759946 -0.0565977417867947 0.65730562864161 mirMAP -0.205449924176427 1.16108027288209e-09 NA NA NA hsa-miR-543 CACNG4 -0.347737549779625 0.0157394585079683 -0.0565977417867947 0.65730562864161 miRanda -0.222886193843364 2.04075903055139e-09 NA NA NA hsa-miR-590-3p CACNG4 0.312951515438396 0.000480455423843996 -0.0565977417867947 0.65730562864161 miRanda -0.478933516912954 8.68382415630933e-17 NA NA NA hsa-miR-28-5p CACNG7 0.104003572105781 0.153594705579534 -0.13255615504768 0.0664530145105342 miRanda -0.141970866508266 0.000419044000374624 NA NA NA hsa-miR-361-3p CACNG7 -0.0798653643614555 0.271064714084553 -0.13255615504768 0.0664530145105342 mirMAP;miRNATAP -0.123377608528938 0.00418656709682873 NA NA NA hsa-miR-532-3p CACNG7 0.150624483952741 0.0599635132177191 -0.13255615504768 0.0664530145105342 miRNATAP -0.218134535522809 3.60287216128128e-10 NA NA NA hsa-let-7c-5p CACNG8 -0.04295851886768 0.676052842748691 -0.340049972772696 0.0486849626292918 miRNAWalker2_validate -0.363212806786018 0.000334903272237218 NA NA NA hsa-miR-141-3p CACNG8 0.41120561991992 0.000393344390969055 -0.340049972772696 0.0486849626292918 mirMAP -0.20877913750081 0.00158647291761865 NA NA NA hsa-miR-200c-3p CACNG8 0.413752622631695 8.6936333715621e-06 -0.340049972772696 0.0486849626292918 mirMAP -0.316562361809981 8.65987667541266e-05 NA NA NA hsa-miR-26b-5p CACNG8 -0.0984536538762768 0.231803769574623 -0.340049972772696 0.0486849626292918 mirMAP -0.316860491563895 0.00394345589700126 NA NA NA hsa-miR-452-5p CACNG8 0.599327068454211 1.02031931068531e-05 -0.340049972772696 0.0486849626292918 mirMAP -0.159711357988782 0.00370830778283587 NA NA NA hsa-miR-500a-3p CACNG8 0.0479457078972052 0.49420307623914 -0.340049972772696 0.0486849626292918 mirMAP -0.383425479428974 0.00248641418330774 NA NA NA hsa-miR-501-5p CACNG8 0.0878951859817452 0.309663377222443 -0.340049972772696 0.0486849626292918 mirMAP -0.24610208783052 0.00504159359670014 NA NA NA hsa-miR-576-5p CACNG8 0.106482276040047 0.194379152564166 -0.340049972772696 0.0486849626292918 mirMAP -0.583105404807422 2.27893492281363e-10 NA NA NA hsa-miR-589-3p CACNG8 0.00739371736361305 0.927768051649329 -0.340049972772696 0.0486849626292918 mirMAP -0.386725258861055 3.33193687273163e-05 NA NA NA hsa-miR-629-3p CACNG8 0.318874955109265 0.00062631284800046 -0.340049972772696 0.0486849626292918 mirMAP -0.351957465535995 1.29423958849845e-05 NA NA NA hsa-miR-708-5p CACNG8 -0.00936519718301376 0.919857671524527 -0.340049972772696 0.0486849626292918 mirMAP -0.448463278662554 3.32059200644821e-07 NA NA NA hsa-miR-92b-5p CACNG8 0.271152239892696 0.0116482127918681 -0.340049972772696 0.0486849626292918 miRNAWalker2_validate -0.488795789849597 1.15059333511648e-12 NA NA NA hsa-let-7g-5p CASP3 -0.0253396334608382 0.742556489443668 0.262751412479442 2.56855295665157e-06 MirTarget;miRNATAP -0.129202676446113 0.000422033827716308 NA NA NA hsa-miR-101-3p CASP3 -0.132333931567244 0.241891922291381 0.262751412479442 2.56855295665157e-06 MirTarget -0.106383210575799 1.67996775990553e-05 NA NA NA hsa-miR-128-3p CASP3 -0.781932174412672 7.1812756321342e-10 0.262751412479442 2.56855295665157e-06 miRNAWalker2_validate -0.154501736884318 6.74484437136043e-18 NA NA NA hsa-miR-138-5p CASP3 -0.616087649920851 1.35200027885729e-05 0.262751412479442 2.56855295665157e-06 miRNAWalker2_validate;miRTarBase -0.113189968294872 3.60467356853659e-14 NA NA NA hsa-miR-139-5p CASP3 -0.647754756897633 2.15378307237163e-06 0.262751412479442 2.56855295665157e-06 miRanda -0.14903095658868 1.69348733053664e-21 NA NA NA hsa-miR-30d-5p CASP3 -0.0607010868720046 0.471410043548794 0.262751412479442 2.56855295665157e-06 miRNAWalker2_validate;miRTarBase;miRNATAP -0.147143327631089 0.000150487575452898 NA NA NA hsa-miR-342-3p CASP3 -0.125683829770877 0.105810751640137 0.262751412479442 2.56855295665157e-06 miRanda -0.139797539988921 6.72797720817884e-06 NA NA NA hsa-miR-374b-5p CASP3 -0.210113949579608 0.0056866083818614 0.262751412479442 2.56855295665157e-06 mirMAP -0.148669291364588 3.58505826678344e-06 NA NA NA hsa-miR-7-1-3p CASP3 -0.0894475316162393 0.37322359785108 0.262751412479442 2.56855295665157e-06 MirTarget -0.104664105333427 1.16615180856721e-06 NA NA NA hsa-miR-491-5p CD14 -0.749881113074983 8.22859263179194e-09 0.343004347634503 0.00706966815468469 miRanda -0.170889732094276 2.16855838057251e-05 NA NA NA hsa-let-7a-5p CDC25B 0.00220017218203594 0.982661524826606 0.311976500963614 2.28977810170594e-07 miRNAWalker2_validate -0.10075917890523 0.00480731811035263 NA NA NA hsa-miR-27b-3p CDC25B -0.0599187745243146 0.58208143475992 0.311976500963614 2.28977810170594e-07 miRNATAP -0.112042646691932 4.20125028256148e-07 NA NA NA hsa-miR-744-5p CDC25B -0.31868579180387 0.000969037378618306 0.311976500963614 2.28977810170594e-07 miRNAWalker2_validate -0.198338532476978 1.47343736306093e-17 NA NA NA hsa-miR-15a-5p CHUK 0.142658985373611 0.0536219185009004 -0.0805827732736795 0.0444542176915521 miRNAWalker2_validate;miRTarBase;MirTarget -0.106856768478998 8.98534595935875e-07 NA NA NA hsa-miR-15b-5p CHUK 0.592863156692837 1.41971517354055e-10 -0.0805827732736795 0.0444542176915521 MirTarget -0.133202016968096 1.16700126521113e-19 NA NA NA hsa-let-7a-3p CRK 0.0530563276543763 0.370749834463566 0.0857717337899517 0.0696931030986054 MirTarget;miRNATAP -0.11627063824923 5.29818401834502e-05 NA NA NA hsa-miR-30c-5p CRK -0.0469114469943097 0.565934557464627 0.0857717337899517 0.0696931030986054 miRNATAP -0.174109089109638 1.62747592732424e-13 NA NA NA hsa-miR-361-5p CRK 0.0107519600643302 0.882230614095565 0.0857717337899517 0.0696931030986054 miRanda;mirMAP -0.104143324500846 6.43677522381318e-05 NA NA NA hsa-miR-141-3p CRKL 0.41120561991992 0.000393344390969055 -0.0901167630380275 0.0894770027910818 mirMAP -0.106626716670284 1.18542556389498e-17 NA NA NA hsa-miR-15a-5p CRKL 0.142658985373611 0.0536219185009004 -0.0901167630380275 0.0894770027910818 miRTarBase;MirTarget;miRNATAP -0.129619095058865 5.00425318677537e-08 NA NA NA hsa-miR-15b-5p CRKL 0.592863156692837 1.41971517354055e-10 -0.0901167630380275 0.0894770027910818 MirTarget;miRNATAP -0.131977645443402 3.96324176905739e-16 NA NA NA hsa-miR-200c-3p CRKL 0.413752622631695 8.6936333715621e-06 -0.0901167630380275 0.0894770027910818 MirTarget;miRNATAP -0.141643697762663 8.5607886319468e-21 NA NA NA hsa-miR-25-3p CRKL 0.316649850160985 0.000777982468387578 -0.0901167630380275 0.0894770027910818 mirMAP -0.107266419667399 1.05716881380608e-07 NA NA NA hsa-miR-29a-5p CRKL -0.0697727833812678 0.350621682973119 -0.0901167630380275 0.0894770027910818 MirTarget -0.118224243215221 2.34643429772898e-09 NA NA NA hsa-miR-30a-5p CRKL -0.062942936611238 0.513851954700252 -0.0901167630380275 0.0894770027910818 MirTarget;mirMAP;miRNATAP -0.182061655152811 1.41710365867159e-13 NA NA NA hsa-miR-30b-5p CRKL -0.0858101016322106 0.263243418521854 -0.0901167630380275 0.0894770027910818 MirTarget;mirMAP -0.199704077081346 3.59269929414858e-19 NA NA NA hsa-miR-30c-5p CRKL -0.0469114469943097 0.565934557464627 -0.0901167630380275 0.0894770027910818 MirTarget;mirMAP;miRNATAP -0.246757850763702 2.25784635591657e-29 NA NA NA hsa-miR-30d-5p CRKL -0.0607010868720046 0.471410043548794 -0.0901167630380275 0.0894770027910818 MirTarget;mirMAP;miRNATAP -0.117579575594101 7.65526724616014e-06 NA NA NA hsa-miR-30e-5p CRKL 0.0764521828640934 0.41904991629622 -0.0901167630380275 0.0894770027910818 MirTarget;mirMAP -0.15346882697441 8.02048771628836e-13 NA NA NA hsa-miR-425-5p CRKL -0.0412837711174561 0.682284485592858 -0.0901167630380275 0.0894770027910818 miRNAWalker2_validate -0.11657803056164 1.00175513004948e-14 NA NA NA hsa-miR-505-3p CRKL 0.115486008167472 0.109833720698312 -0.0901167630380275 0.0894770027910818 MirTarget -0.142188987181044 1.62163349495458e-11 NA NA NA hsa-miR-590-3p CRKL 0.312951515438396 0.000480455423843996 -0.0901167630380275 0.0894770027910818 MirTarget;PITA;miRanda;miRNATAP -0.124133416584021 7.18612744399472e-15 NA NA NA hsa-miR-590-5p CRKL 0.16946027035949 0.0386004382081678 -0.0901167630380275 0.0894770027910818 miRanda -0.118428884755512 2.97552720244048e-11 NA NA NA hsa-miR-98-5p CRKL -0.0806971683871618 0.251777941211683 -0.0901167630380275 0.0894770027910818 miRNAWalker2_validate -0.134270609832393 9.43669020894701e-09 NA NA NA hsa-miR-183-5p DUSP10 -0.122352002042746 0.484640364004636 0.568798897408548 7.63511218342876e-10 MirTarget;miRNATAP -0.104177870521736 1.35880940860583e-05 NA NA NA hsa-miR-320a DUSP3 0.092135599636725 0.243028758989929 -0.0216471563443346 0.710083066772753 mirMAP -0.102122544177084 0.00245700013513781 NA NA NA hsa-let-7i-5p DUSP4 0.0952853587923244 0.192120688957249 0.647784174413485 5.02774820852245e-05 miRNATAP -0.384703853859819 0.00177654729719568 NA NA NA hsa-miR-1226-3p DUSP4 -0.098618802853881 0.346683714981524 0.647784174413485 5.02774820852245e-05 mirMAP -0.314479869291934 2.84467170816733e-06 NA NA NA hsa-miR-26b-3p DUSP4 -0.0542537787460029 0.4802214385739 0.647784174413485 5.02774820852245e-05 mirMAP -0.481918528992718 3.40358517025404e-07 NA NA NA hsa-miR-3065-5p DUSP4 -0.262608140481507 0.0414570974148034 0.647784174413485 5.02774820852245e-05 mirMAP -0.651864287547209 3.60245692088584e-37 NA NA NA hsa-miR-491-3p DUSP4 -0.523374665885358 1.93479565404951e-05 0.647784174413485 5.02774820852245e-05 MirTarget -0.191615225160342 0.000805786570343135 NA NA NA hsa-miR-589-3p DUSP4 0.00739371736361305 0.927768051649329 0.647784174413485 5.02774820852245e-05 mirMAP -0.391084119051206 6.94804338998967e-06 NA NA NA hsa-miR-9-3p DUSP4 -0.184945845984695 0.0290051908009009 0.647784174413485 5.02774820852245e-05 mirMAP -0.4635205538 4.06474780988613e-05 NA NA NA hsa-miR-135a-5p DUSP5 -0.122734612943241 0.196985964641886 0.740553992422679 3.04213829086128e-07 miRNATAP -0.309197404976288 7.45526508963999e-06 NA NA NA hsa-miR-92b-3p DUSP5 -0.213968504161963 0.0523921855715716 0.740553992422679 3.04213829086128e-07 MirTarget;miRNATAP -0.234916761776894 0.000471202752662712 NA NA NA hsa-miR-186-5p DUSP6 0.0606381894130505 0.514217717592464 0.540896978600411 8.15731501150624e-08 mirMAP -0.161338442999276 0.0017040792238093 NA NA NA hsa-let-7c-5p DUSP7 -0.04295851886768 0.676052842748691 -0.153823116090043 0.00405709205994704 miRNAWalker2_validate -0.139727286666787 2.09622891852266e-07 NA NA NA hsa-miR-21-5p DUSP8 1.0504925175311 2.58081295984106e-11 -0.17515174843211 0.0382928021347344 miRNAWalker2_validate;MirTarget -0.22189839167749 7.87221670188543e-20 NA NA NA hsa-miR-30a-3p DUSP8 0.0655410309550977 0.509541256241954 -0.17515174843211 0.0382928021347344 MirTarget;miRNATAP -0.244062741896031 1.11239873506966e-07 NA NA NA hsa-miR-320a DUSP8 0.092135599636725 0.243028758989929 -0.17515174843211 0.0382928021347344 miRNAWalker2_validate -0.220580965014477 7.98483202428867e-05 NA NA NA hsa-miR-374a-5p DUSP8 0.0121037060909277 0.865417963345881 -0.17515174843211 0.0382928021347344 MirTarget -0.194332672099264 0.00026937943338354 NA NA NA hsa-miR-450b-5p DUSP8 0.270544879013992 0.00801537838499562 -0.17515174843211 0.0382928021347344 miRNATAP -0.106042055793603 0.00256730684210498 NA NA NA hsa-miR-590-5p DUSP8 0.16946027035949 0.0386004382081678 -0.17515174843211 0.0382928021347344 MirTarget;PITA;miRanda;miRNATAP -0.132114684273663 0.00247863992965598 NA NA NA hsa-miR-93-5p DUSP8 0.139766237971122 0.101057320076629 -0.17515174843211 0.0382928021347344 miRNAWalker2_validate;MirTarget;miRNATAP -0.204235125799178 0.00141638071808645 NA NA NA hsa-let-7e-5p DUSP9 0.0471189209570344 0.657255455444655 -0.617638569363925 6.38711365503883e-05 miRNATAP -0.424713569890156 1.28430016871331e-08 NA NA NA hsa-let-7f-5p DUSP9 0.0508269185845673 0.62677515045793 -0.617638569363925 6.38711365503883e-05 miRNATAP -0.222646190699495 0.00974356790624495 NA NA NA hsa-let-7g-5p DUSP9 -0.0253396334608382 0.742556489443668 -0.617638569363925 6.38711365503883e-05 miRNATAP -0.414043066928226 0.000331589394714047 NA NA NA hsa-let-7i-5p DUSP9 0.0952853587923244 0.192120688957249 -0.617638569363925 6.38711365503883e-05 miRNATAP -0.961703347572905 7.75632816479449e-17 NA NA NA hsa-miR-100-5p DUSP9 0.0939087252225708 0.437623927320764 -0.617638569363925 6.38711365503883e-05 mirMAP -0.479917345837181 9.2561400170877e-13 NA NA NA hsa-miR-106b-5p DUSP9 0.167096183547615 0.0497544396383451 -0.617638569363925 6.38711365503883e-05 mirMAP -0.414103933558044 4.28324855288173e-06 NA NA NA hsa-miR-1301-3p DUSP9 -0.105695714210758 0.152249184194132 -0.617638569363925 6.38711365503883e-05 MirTarget -0.3552202109367 0.000209187935096063 NA NA NA hsa-miR-17-5p DUSP9 0.0975751369167082 0.20621110214601 -0.617638569363925 6.38711365503883e-05 mirMAP -0.344931357231012 0.00162376308332381 NA NA NA hsa-miR-20b-5p DUSP9 0.144541062989476 0.0992042333556543 -0.617638569363925 6.38711365503883e-05 mirMAP -0.338709061589759 4.86761458897884e-05 NA NA NA hsa-miR-30a-3p DUSP9 0.0655410309550977 0.509541256241954 -0.617638569363925 6.38711365503883e-05 MirTarget -0.549145839295757 4.48779141333565e-10 NA NA NA hsa-miR-30d-3p DUSP9 0.0854049347792898 0.20691254801121 -0.617638569363925 6.38711365503883e-05 MirTarget -0.313199576020238 0.00203481659315303 NA NA NA hsa-miR-30e-3p DUSP9 0.00173769765874887 0.984965501547409 -0.617638569363925 6.38711365503883e-05 MirTarget -0.66049547051834 2.92441848159602e-11 NA NA NA hsa-miR-362-3p DUSP9 0.032375035235532 0.736465332563774 -0.617638569363925 6.38711365503883e-05 miRNATAP -0.242998477420758 0.000599772876933179 NA NA NA hsa-miR-452-5p DUSP9 0.599327068454211 1.02031931068531e-05 -0.617638569363925 6.38711365503883e-05 MirTarget -0.381011941581796 3.31135426383132e-15 NA NA NA hsa-miR-542-3p DUSP9 0.0835995677900829 0.403838744494071 -0.617638569363925 6.38711365503883e-05 miRanda -0.336937879038895 6.83373248381505e-06 NA NA NA hsa-miR-98-5p DUSP9 -0.0806971683871618 0.251777941211683 -0.617638569363925 6.38711365503883e-05 miRNAWalker2_validate -0.507733987481937 3.25510517767826e-06 NA NA NA hsa-miR-99a-5p DUSP9 -0.120081919053582 0.258277048014275 -0.617638569363925 6.38711365503883e-05 mirMAP -0.276197285752214 0.000631924938096792 NA NA NA hsa-miR-142-3p ECSIT 0.558908907203977 1.37828834702416e-05 -0.0777976130722262 0.180036743859291 miRanda -0.178838712838347 1.04507873571507e-28 NA NA NA hsa-miR-455-3p ECSIT 0.512701816402104 0.000459755983280155 -0.0777976130722262 0.180036743859291 miRNATAP -0.164900846246527 2.54609949445327e-33 NA NA NA hsa-miR-532-5p ECSIT 0.0263466708637097 0.75763006039876 -0.0777976130722262 0.180036743859291 miRNATAP -0.192493234061197 1.26017693309031e-10 NA NA NA hsa-miR-105-5p EGFR -0.567459149851677 8.20858944634795e-06 0.375473556369618 0.0155485714375729 mirMAP -0.353346118507539 9.24874721523108e-12 NA NA NA hsa-miR-133a-3p EGFR -0.335058908302964 0.0180402783121034 0.375473556369618 0.0155485714375729 miRNAWalker2_validate;miRTarBase;MirTarget -0.240130883772277 1.69412746009746e-07 26138587;26076812;25903369;26134491;24816813;22407299;27465833;23786162 Growth of glioblastoma is inhibited by miR 133 mediated EGFR suppression; Bioinformatic analysis was performed showing that miR-133 may target the 3'-untranslated region 3'-UTR of the epidermal growth factor receptor EGFR that transduces cell growth signals; Further the protein translation inhibition of EGFR by miR-133 was confirmed by a dual luciferase reporter assay; Together these data suggest that reduced miR-133 levels in GBM tissues promotes cell growth and decreases cell apoptosis possibly through targeting mRNA of EGFR to suppress its translation;Moreover the 3'-untranslated region 3'UTR of Her-2 the epidermal growth factor receptor EGFR that transduces cell growth signals appeared to be targeted by miR-133;MiR-133a expression was negatively correlated to lymphatic metastasis r = -0.182 P = 0.042 tumor size r = -0.253 P = 0.04 clinical TNM stages r = -0.154 P = 0.087 and EGFR protein expression r = -0.612 P < 0.001;miR 133a inhibits cervical cancer growth by targeting EGFR; The epidermal growth factor receptor EGFR was confirmed to be a direct target of miR-133a in cervical cancer cells using luciferase assay and western blotting; Restoration of miR-133a inhibited EGFR expression and activated the AKT and ERK signaling pathways; These results showed that miR-133a suppresses cervical cancer growth in vitro and in vivo through targeting EGFR suggesting that miR-133a can be a potential target for the treatment of cervical cancer;MiR-133a can inhibit cell invasiveness and cell growth through suppressing the expressions of IGF-1R TGFBR1 and EGFR which then influences the downstream signaling in lung cancer cell lines;We also provide the first evidence that miR-133 may target EGFR;Epidermal growth factor receptor EGFR expression and Akt phosphorylation were significantly suppressed after miR-133a transfection by western blot detection; miR-133a suppressed cell proliferation by suppressing the expression of EGFR and the phosphorylation of Akt;Bioinformatics prediction showed that epidermal growth factor receptor EGFR is a potential target for miR-133a; A dual luciferase reporter gene assay showed that miR-133a bound to the 3' UTR of EGFR but not a mutated 3' UTR thereby down-regulating the protein expression level; Accordingly we found that expression of EGFR protein decreased with increased expression of miR-133a in MCF-7 and MDA-MB-231 cells; These results demonstrate that miR-133a which may act as a tumor suppressor in breast cancer regulates the cell cycle and proliferation in tumorigenesis by targeting EGFR through the downstream signal molecule Akt ;;staging;metastasis;tumor size;;;;;tumorigenesis glioblastoma;gastric cancer;lung squamous cell cancer;cervical and endocervical cancer;lung squamous cell cancer;prostate cancer;breast cancer;breast cancer hsa-miR-134-5p EGFR 0.0228681180463912 0.875465441075562 0.375473556369618 0.0155485714375729 MirTarget -0.131424347245258 0.0046901253546818 24440911;27241841 We show that the RTKs MET EGFR and PDGFR regulate microRNA-134 miR-134 in GBM; We find that miR-134 is downregulated in human tumors and cancer stem cells and that its expression inversely correlates with the activation of MET EGFR and PDGFR;Luciferase assays confirmed that EGFR is a direct target of miR-134; Further mechanistic investigation including RNAi and rescue experiments suggested that the down-regulation of EGFR by miR-134 partially contributes to the antiproliferative role of miR-134; Taken together our findings suggest that miR-134 inhibits non-small cell lung cancer growth by targeting the EGFR ; glioblastoma;lung squamous cell cancer hsa-miR-140-5p EGFR 0.065063507103468 0.380452509211773 0.375473556369618 0.0155485714375729 miRanda -0.331443926880394 0.000604746363683769 NA NA NA hsa-miR-141-3p EGFR 0.41120561991992 0.000393344390969055 0.375473556369618 0.0155485714375729 MirTarget -0.272211860280112 2.20526685695345e-06 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-145-5p EGFR 0.108948399943015 0.310032352776693 0.375473556369618 0.0155485714375729 miRTarBase -0.222408723457338 0.000632008424910129 21653642;21289483;19493678 EGFR signals downregulate tumor suppressors miR 143 and miR 145 in Western diet promoted murine colon cancer: role of G1 regulators; Effects of EGFR on miR-143 and miR-145 expression were assessed in murine and human colonic cells and their putative targets examined in vitro and in vivo; EGFR signals suppressed miR-143 and miR-145 in human and murine colonic cells; EGFR suppresses miR-143 and miR-145 in murine models of colon cancer;MiR 145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1; We previously reported that restoration of hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor EGFR mutation; The mRNA expressions of EGFR and NUDT1 were significantly downregulated after miR-145 transfection in human lung adenocarcinoma cells; Our results demonstrated miR-145 in the negative regulation of EGFR and NUDT1 expressions at both mRNA and protein levels; Upregulation of miR-145 appeared to be an important gene regulation mechanism for the proliferation of lung adenocarcinoma cells and it correlated strongly with the downregulation of EGFR and NUDT1; Our findings provided new insight into the complex regulating pathway comprising of miR-145 EGFR NUDT1 and other unknown factors which function in cell proliferation but not in apoptosis;Our results also show that restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in EGFR mutant lung adenocarcinoma ;; colon cancer;lung cancer;lung cancer hsa-miR-146b-5p EGFR 0.441078059667297 0.000237619929889385 0.375473556369618 0.0155485714375729 miRNATAP -0.182905457755479 0.00149160880673993 NA NA NA hsa-miR-148b-5p EGFR 0.127111784487801 0.188731110216917 0.375473556369618 0.0155485714375729 mirMAP -0.239934018287681 0.000528231733121031 NA NA NA hsa-miR-17-5p EGFR 0.0975751369167082 0.20621110214601 0.375473556369618 0.0155485714375729 TargetScan -0.300424779505137 0.00473688540815432 NA NA NA hsa-miR-186-5p EGFR 0.0606381894130505 0.514217717592464 0.375473556369618 0.0155485714375729 mirMAP -0.362820595408749 3.23429208060765e-06 NA NA NA hsa-miR-199a-3p EGFR 0.41226331871076 0.000497136154474528 0.375473556369618 0.0155485714375729 mirMAP -0.155171655893965 0.00605438554579962 NA NA NA hsa-miR-199b-3p EGFR 0.411848361704393 0.000517815011892379 0.375473556369618 0.0155485714375729 mirMAP -0.153587230840804 0.00647308065495246 NA NA NA hsa-miR-27b-3p EGFR -0.0599187745243146 0.58208143475992 0.375473556369618 0.0155485714375729 MirTarget;miRNATAP -0.221076471767459 0.000976089469884623 NA NA NA hsa-miR-29b-2-5p EGFR -0.26834261955727 0.00453760540520233 0.375473556369618 0.0155485714375729 mirMAP -0.358417872879751 3.99667666062669e-07 NA NA NA hsa-miR-340-5p EGFR -0.110504550202736 0.20522426193476 0.375473556369618 0.0155485714375729 mirMAP -0.346218765115495 1.66785221313902e-05 NA NA NA hsa-miR-342-3p EGFR -0.125683829770877 0.105810751640137 0.375473556369618 0.0155485714375729 miRanda -0.663917527907302 1.30767225931049e-12 NA NA NA hsa-miR-362-5p EGFR -0.0730185557229279 0.425572997292224 0.375473556369618 0.0155485714375729 mirMAP -0.425583661873956 4.49473787679401e-09 NA NA NA hsa-miR-374a-3p EGFR 0.176226170437625 0.0343958848425446 0.375473556369618 0.0155485714375729 mirMAP -0.362986532828884 0.000239618326261467 NA NA NA hsa-miR-374b-3p EGFR 0.00769406264478478 0.897944859266164 0.375473556369618 0.0155485714375729 mirMAP -0.427233704833407 0.000162731500775749 NA NA NA hsa-miR-375 EGFR -0.0268401141324031 0.858358101444697 0.375473556369618 0.0155485714375729 miRanda -0.169128003930842 0.000103586363427282 NA NA NA hsa-miR-432-5p EGFR -0.214242438141977 0.166186087759946 0.375473556369618 0.0155485714375729 mirMAP -0.131937974290007 0.0019216701815729 NA NA NA hsa-miR-455-5p EGFR 0.332224239762 0.0106491358056238 0.375473556369618 0.0155485714375729 miRanda -0.204812179021233 5.18972286460639e-05 NA NA NA hsa-miR-490-3p EGFR -0.834268051506884 5.26203010743215e-06 0.375473556369618 0.0155485714375729 miRNATAP -0.120072101708822 0.00092511979931243 NA NA NA hsa-miR-491-5p EGFR -0.749881113074983 8.22859263179194e-09 0.375473556369618 0.0155485714375729 miRanda -0.15355901980036 0.00200795950337826 25299770 This latter effect is due to direct targeting of epidermal growth factor receptor EGFR by miR-491-5p and consequent inhibition of downstream AKT and MAPK signalling pathways; Induction of apoptosis by miR-491-5p in this cell line is mimicked by a combination of EGFR inhibition together with a BH3-mimetic molecule ovarian cancer hsa-miR-501-5p EGFR 0.0878951859817452 0.309663377222443 0.375473556369618 0.0155485714375729 mirMAP -0.204458704242994 0.00778191664099004 NA NA NA hsa-miR-539-5p EGFR -0.326485413953598 0.0554453076411246 0.375473556369618 0.0155485714375729 MirTarget;mirMAP -0.164306654210725 1.88169889749939e-05 NA NA NA hsa-miR-542-3p EGFR 0.0835995677900829 0.403838744494071 0.375473556369618 0.0155485714375729 miRanda -0.200337541146819 0.00617654519167961 NA NA NA hsa-miR-577 EGFR -0.382068371859275 0.0145513192729119 0.375473556369618 0.0155485714375729 mirMAP -0.117018511597701 0.00601694200161573 NA NA NA hsa-miR-590-3p EGFR 0.312951515438396 0.000480455423843996 0.375473556369618 0.0155485714375729 mirMAP -0.214045002105238 0.00365962356824128 NA NA NA hsa-miR-654-3p EGFR -0.00355488592826836 0.97967144096285 0.375473556369618 0.0155485714375729 mirMAP -0.128189186321505 0.00719754733314809 NA NA NA hsa-miR-7-1-3p EGFR -0.0894475316162393 0.37322359785108 0.375473556369618 0.0155485714375729 mirMAP -0.276379724120531 2.83072126766495e-05 NA NA NA hsa-miR-769-5p EGFR -0.320572895263071 0.00425481410304398 0.375473556369618 0.0155485714375729 mirMAP -0.16419521509748 0.00642768950459396 NA NA NA hsa-miR-877-5p EGFR -0.0775421790642756 0.423413623033696 0.375473556369618 0.0155485714375729 mirMAP -0.212946423195282 0.00180004411848772 NA NA NA hsa-miR-135a-5p ELK4 -0.122734612943241 0.196985964641886 0.174787970155637 0.00761093370955428 miRNATAP -0.147071992238075 1.69304866498653e-06 NA NA NA hsa-miR-19b-3p ELK4 -0.0138427450847924 0.856506310673067 0.174787970155637 0.00761093370955428 mirMAP -0.11677218797178 0.00598921192050639 NA NA NA hsa-miR-30b-5p ELK4 -0.0858101016322106 0.263243418521854 0.174787970155637 0.00761093370955428 mirMAP -0.214882534480987 1.2992041415241e-06 NA NA NA hsa-miR-30c-5p ELK4 -0.0469114469943097 0.565934557464627 0.174787970155637 0.00761093370955428 mirMAP -0.264963350310156 2.24967290672679e-09 NA NA NA hsa-miR-342-3p ELK4 -0.125683829770877 0.105810751640137 0.174787970155637 0.00761093370955428 mirMAP -0.162511208628155 7.12589227483911e-05 NA NA NA hsa-miR-362-5p ELK4 -0.0730185557229279 0.425572997292224 0.174787970155637 0.00761093370955428 mirMAP -0.282332171232543 1.89673530356333e-20 NA NA NA hsa-miR-365a-3p ELK4 -0.184222766207919 0.0292663235724171 0.174787970155637 0.00761093370955428 mirMAP -0.138014751061007 5.95967907818514e-05 NA NA NA hsa-miR-500a-5p ELK4 0.0634452729978863 0.396072382601677 0.174787970155637 0.00761093370955428 mirMAP -0.119354342644424 0.00179213333017117 NA NA NA hsa-miR-504-5p FAS -0.510726779625117 6.12122269907368e-05 0.265125211236005 0.00536978445115343 miRNAWalker2_validate -0.123587493507518 0.000186057016947978 NA NA NA hsa-let-7d-5p FGF11 0.111345229817909 0.0872634398336815 -0.235018569265848 0.00440939153265794 mirMAP;miRNATAP -0.539705813701275 3.46462978181246e-18 NA NA NA hsa-let-7e-5p FGF11 0.0471189209570344 0.657255455444655 -0.235018569265848 0.00440939153265794 mirMAP;miRNATAP -0.272669366101863 7.34562908174005e-14 NA NA NA hsa-let-7f-5p FGF11 0.0508269185845673 0.62677515045793 -0.235018569265848 0.00440939153265794 mirMAP;miRNATAP -0.15253479478004 0.000320003174670443 NA NA NA hsa-let-7g-5p FGF11 -0.0253396334608382 0.742556489443668 -0.235018569265848 0.00440939153265794 mirMAP;miRNATAP -0.256034055595292 6.39523006394648e-06 NA NA NA hsa-let-7i-5p FGF11 0.0952853587923244 0.192120688957249 -0.235018569265848 0.00440939153265794 miRNATAP -0.323507607251771 2.41702652033077e-08 NA NA NA hsa-miR-1226-3p FGF11 -0.098618802853881 0.346683714981524 -0.235018569265848 0.00440939153265794 mirMAP -0.215873498479599 8.3092578295701e-12 NA NA NA hsa-miR-125a-3p FGF11 0.183834985432376 0.106230647107917 -0.235018569265848 0.00440939153265794 miRanda -0.220387739616411 4.2677254499296e-14 NA NA NA hsa-miR-125a-5p FGF11 -0.0833349424517387 0.325440200253607 -0.235018569265848 0.00440939153265794 mirMAP -0.399141179421754 4.42388956486495e-17 NA NA NA hsa-miR-125b-5p FGF11 -0.0119698382910496 0.890233923197358 -0.235018569265848 0.00440939153265794 mirMAP -0.300364716646036 2.460478659499e-07 NA NA NA hsa-miR-130b-5p FGF11 0.413070888963592 1.98866876365509e-06 -0.235018569265848 0.00440939153265794 mirMAP -0.129307922513196 0.00115639283572434 NA NA NA hsa-miR-15b-3p FGF11 0.690804403863844 8.48784755123775e-09 -0.235018569265848 0.00440939153265794 MirTarget -0.238742383514492 2.59789395249708e-19 NA NA NA hsa-miR-16-5p FGF11 0.246024668671282 0.00346042804503716 -0.235018569265848 0.00440939153265794 mirMAP -0.253885121824312 5.44203675685023e-08 NA NA NA hsa-miR-181a-5p FGF11 -0.178215604431845 0.0700010802255601 -0.235018569265848 0.00440939153265794 mirMAP -0.121480612085174 0.00953424365553838 NA NA NA hsa-miR-181b-5p FGF11 0.0260899284211646 0.768941836912518 -0.235018569265848 0.00440939153265794 mirMAP -0.216091901390167 4.37071492449882e-06 NA NA NA hsa-miR-193b-3p FGF11 0.0766333116224072 0.324723824453143 -0.235018569265848 0.00440939153265794 miRNAWalker2_validate -0.163790513828313 0.000308059901870561 NA NA NA hsa-miR-199a-5p FGF11 0.174889610847968 0.0900027418912454 -0.235018569265848 0.00440939153265794 miRanda -0.123545036604956 0.000174808908676321 NA NA NA hsa-miR-199b-5p FGF11 0.436298593972862 0.00200225454383871 -0.235018569265848 0.00440939153265794 miRanda -0.16382095505275 1.58231259921081e-12 NA NA NA hsa-miR-2355-5p FGF11 0.00808596988211185 0.916165501155096 -0.235018569265848 0.00440939153265794 mirMAP -0.404493707556144 9.44226447177025e-20 NA NA NA hsa-miR-28-5p FGF11 0.104003572105781 0.153594705579534 -0.235018569265848 0.00440939153265794 miRanda -0.300015659036983 9.49162856500363e-10 NA NA NA hsa-miR-30c-1-3p FGF11 0.0175008295781193 0.849381871022214 -0.235018569265848 0.00440939153265794 MirTarget -0.231888561690859 2.21641993413236e-10 NA NA NA hsa-miR-3127-5p FGF11 -0.0645479321229978 0.382330591204685 -0.235018569265848 0.00440939153265794 MirTarget -0.338870271012372 5.37567519810833e-14 NA NA NA hsa-miR-320c FGF11 0.343259124189966 0.000248338401291051 -0.235018569265848 0.00440939153265794 miRanda -0.104283413045425 0.00462086226364477 NA NA NA hsa-miR-324-5p FGF11 0.0183370482495953 0.842996782677271 -0.235018569265848 0.00440939153265794 miRanda -0.36724232915858 4.00522299245935e-25 NA NA NA hsa-miR-330-5p FGF11 -0.262932095995605 0.0465226565966658 -0.235018569265848 0.00440939153265794 MirTarget;PITA;miRanda;miRNATAP -0.195003196729419 3.80014150378446e-15 NA NA NA hsa-miR-331-3p FGF11 0.0126984726684189 0.905175053956974 -0.235018569265848 0.00440939153265794 miRNATAP -0.248282800419238 1.47164026963049e-15 NA NA NA hsa-miR-335-5p FGF11 0.0938511632756978 0.336889056387694 -0.235018569265848 0.00440939153265794 miRNAWalker2_validate;mirMAP -0.102652960252214 0.00341885696268571 NA NA NA hsa-miR-339-5p FGF11 0.273253751377152 0.0185300170790638 -0.235018569265848 0.00440939153265794 miRanda -0.192448682459769 1.30310049315034e-11 NA NA NA hsa-miR-432-5p FGF11 -0.214242438141977 0.166186087759946 -0.235018569265848 0.00440939153265794 mirMAP -0.188236536467299 2.1710514664352e-19 NA NA NA hsa-miR-532-3p FGF11 0.150624483952741 0.0599635132177191 -0.235018569265848 0.00440939153265794 mirMAP -0.160139075795999 0.0002261365465316 NA NA NA hsa-miR-548b-3p FGF11 0.340474544210108 0.00224491592019745 -0.235018569265848 0.00440939153265794 mirMAP -0.256817435326662 3.55493816294849e-18 NA NA NA hsa-miR-628-5p FGF11 -0.0469793532265896 0.657420003383685 -0.235018569265848 0.00440939153265794 miRNATAP -0.294133448795464 4.10014422796776e-21 NA NA NA hsa-miR-142-5p FGF12 0.434884875454107 0.000575570345702788 -0.341174347829348 0.00108179644535172 miRNATAP -0.221343945375644 9.7510045039636e-11 NA NA NA hsa-miR-200b-3p FGF12 0.245768526504511 0.0580744465744737 -0.341174347829348 0.00108179644535172 TargetScan -0.282089673650438 6.08610087552928e-17 NA NA NA hsa-miR-217 FGF12 0.540279882451941 0.00312206944061206 -0.341174347829348 0.00108179644535172 miRanda -0.180715339357903 1.50784321290264e-14 NA NA NA hsa-miR-2355-3p FGF12 0.186207523505296 0.0525918026993012 -0.341174347829348 0.00108179644535172 MirTarget;miRNATAP -0.231026550449217 3.7230945566169e-07 NA NA NA hsa-miR-3065-5p FGF12 -0.262608140481507 0.0414570974148034 -0.341174347829348 0.00108179644535172 mirMAP -0.1013901905804 0.00321299126471714 NA NA NA hsa-miR-335-3p FGF12 0.34540584335595 0.00043848660222294 -0.341174347829348 0.00108179644535172 MirTarget -0.150595502597158 0.00121258088251763 NA NA NA hsa-miR-362-3p FGF12 0.032375035235532 0.736465332563774 -0.341174347829348 0.00108179644535172 miRanda -0.173543809213136 0.000157836462891801 NA NA NA hsa-miR-3682-3p FGF12 0.113471485204649 0.266481019608971 -0.341174347829348 0.00108179644535172 MirTarget -0.262952473970731 2.37222373386136e-09 NA NA NA hsa-miR-455-5p FGF12 0.332224239762 0.0106491358056238 -0.341174347829348 0.00108179644535172 miRanda -0.224899082272953 1.63021966242583e-11 NA NA NA hsa-miR-501-5p FGF12 0.0878951859817452 0.309663377222443 -0.341174347829348 0.00108179644535172 MirTarget;PITA -0.257820236542007 4.14825558157776e-07 NA NA NA hsa-miR-542-3p FGF12 0.0835995677900829 0.403838744494071 -0.341174347829348 0.00108179644535172 miRanda -0.215735316621216 9.2374079674621e-06 NA NA NA hsa-miR-576-5p FGF12 0.106482276040047 0.194379152564166 -0.341174347829348 0.00108179644535172 mirMAP -0.290746464930981 7.73109194139942e-08 NA NA NA hsa-miR-590-3p FGF12 0.312951515438396 0.000480455423843996 -0.341174347829348 0.00108179644535172 mirMAP -0.29979405572985 6.75200328981588e-10 NA NA NA hsa-miR-1262 FGF13 0.276259331706731 0.0259799942226561 -0.706826351179643 1.15125565809917e-06 MirTarget;PITA;miRNATAP -0.343876045827969 2.47310188991752e-11 NA NA NA hsa-miR-141-3p FGF13 0.41120561991992 0.000393344390969055 -0.706826351179643 1.15125565809917e-06 TargetScan -0.224532540308352 5.58413842670053e-05 NA NA NA hsa-miR-142-5p FGF13 0.434884875454107 0.000575570345702788 -0.706826351179643 1.15125565809917e-06 PITA -0.291867410048386 3.93193139922811e-09 NA NA NA hsa-miR-34c-5p FGF13 0.181931113688093 0.257266965617363 -0.706826351179643 1.15125565809917e-06 miRanda -0.119115228141567 0.00246321570966122 NA NA NA hsa-miR-3682-3p FGF13 0.113471485204649 0.266481019608971 -0.706826351179643 1.15125565809917e-06 MirTarget -0.336026296198332 1.42601055678693e-07 NA NA NA hsa-miR-455-5p FGF13 0.332224239762 0.0106491358056238 -0.706826351179643 1.15125565809917e-06 PITA;miRanda -0.228084495997694 2.90950842226493e-06 NA NA NA hsa-miR-542-3p FGF13 0.0835995677900829 0.403838744494071 -0.706826351179643 1.15125565809917e-06 miRanda -0.249164166181018 0.000410048353399803 NA NA NA hsa-miR-548b-3p FGF13 0.340474544210108 0.00224491592019745 -0.706826351179643 1.15125565809917e-06 PITA -0.208062810230116 0.000321083900949721 NA NA NA hsa-miR-590-3p FGF13 0.312951515438396 0.000480455423843996 -0.706826351179643 1.15125565809917e-06 miRanda -0.476448111326993 9.26782882672395e-12 NA NA NA hsa-miR-125a-3p FGF14 0.183834985432376 0.106230647107917 -0.398515744120357 0.000209763793404898 miRanda -0.18209547085274 8.59757723382675e-06 NA NA NA hsa-miR-193a-5p FGF14 0.183172152450491 0.0749251910521214 -0.398515744120357 0.000209763793404898 TargetScan -0.245243369908449 9.67804779852833e-08 NA NA NA hsa-miR-362-3p FGF14 0.032375035235532 0.736465332563774 -0.398515744120357 0.000209763793404898 miRanda -0.188865716800422 8.54829762691488e-05 NA NA NA hsa-miR-421 FGF14 -0.171573235029879 0.0518112933651029 -0.398515744120357 0.000209763793404898 miRanda -0.253745288160661 1.23339623348382e-06 NA NA NA hsa-miR-590-3p FGF14 0.312951515438396 0.000480455423843996 -0.398515744120357 0.000209763793404898 miRanda -0.301628753406604 3.20594125245951e-09 NA NA NA hsa-miR-331-3p FGF17 0.0126984726684189 0.905175053956974 -0.747209687668737 1.81064553707654e-05 mirMAP -0.337058286685929 3.52810699933431e-06 NA NA NA hsa-let-7a-3p FGF2 0.0530563276543763 0.370749834463566 -0.310412510487203 1.0531264899139e-05 mirMAP -0.213352464353633 3.01948138253891e-05 NA NA NA hsa-let-7f-1-3p FGF2 0.110713086694053 0.21484524300518 -0.310412510487203 1.0531264899139e-05 mirMAP -0.103512481979716 0.000647773517119759 NA NA NA hsa-miR-103a-3p FGF2 -0.147443193527362 0.128400914654149 -0.310412510487203 1.0531264899139e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.12655516361281 0.00679371182948832 NA NA NA hsa-miR-126-5p FGF2 0.177332403948664 0.0711675116243123 -0.310412510487203 1.0531264899139e-05 mirMAP -0.110162176340636 0.000136298645021207 NA NA NA hsa-miR-140-5p FGF2 0.065063507103468 0.380452509211773 -0.310412510487203 1.0531264899139e-05 miRNAWalker2_validate -0.185361566298031 2.74319630927397e-06 NA NA NA hsa-miR-146a-5p FGF2 0.148942451196282 0.114229072828724 -0.310412510487203 1.0531264899139e-05 mirMAP -0.146277493567259 4.31070451040202e-07 NA NA NA hsa-miR-15a-5p FGF2 0.142658985373611 0.0536219185009004 -0.310412510487203 1.0531264899139e-05 MirTarget;miRNATAP -0.207678236164206 2.5972218474549e-06 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-3p FGF2 0.690804403863844 8.48784755123775e-09 -0.310412510487203 1.0531264899139e-05 mirMAP -0.137724123749645 3.22216944518618e-10 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGF2 0.592863156692837 1.41971517354055e-10 -0.310412510487203 1.0531264899139e-05 MirTarget;miRNATAP -0.259712883212368 3.66212966170394e-18 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-2-3p FGF2 0.468816222075619 7.04377763166292e-05 -0.310412510487203 1.0531264899139e-05 mirMAP -0.160896949653708 5.53366478735585e-13 NA NA NA hsa-miR-16-5p FGF2 0.246024668671282 0.00346042804503716 -0.310412510487203 1.0531264899139e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.238035584676493 2.36870334343313e-10 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-181a-5p FGF2 -0.178215604431845 0.0700010802255601 -0.310412510487203 1.0531264899139e-05 mirMAP -0.123717144171581 0.00107047935591826 NA NA NA hsa-miR-181b-5p FGF2 0.0260899284211646 0.768941836912518 -0.310412510487203 1.0531264899139e-05 mirMAP -0.215729610871528 1.18634456085395e-08 NA NA NA hsa-miR-19b-1-5p FGF2 0.0686579042235509 0.332645627997485 -0.310412510487203 1.0531264899139e-05 mirMAP -0.201459709129831 1.90976689008877e-07 NA NA NA hsa-miR-20a-3p FGF2 0.102743778777997 0.19677865359751 -0.310412510487203 1.0531264899139e-05 mirMAP -0.144973090746876 2.52878071686245e-05 NA NA NA hsa-miR-335-3p FGF2 0.34540584335595 0.00043848660222294 -0.310412510487203 1.0531264899139e-05 mirMAP -0.178439766262418 2.49255926048001e-10 NA NA NA hsa-miR-335-5p FGF2 0.0938511632756978 0.336889056387694 -0.310412510487203 1.0531264899139e-05 miRNATAP -0.140124965064104 6.34697534647765e-07 NA NA NA hsa-miR-361-5p FGF2 0.0107519600643302 0.882230614095565 -0.310412510487203 1.0531264899139e-05 mirMAP -0.181723993106071 8.88544014107461e-05 NA NA NA hsa-miR-376a-5p FGF2 -0.0877544252790136 0.551096721204598 -0.310412510487203 1.0531264899139e-05 mirMAP -0.113264250236629 1.03177567762586e-09 NA NA NA hsa-miR-376c-3p FGF2 -0.0513360810290662 0.710610589791979 -0.310412510487203 1.0531264899139e-05 mirMAP -0.132449788888867 7.98306703791068e-12 NA NA NA hsa-miR-424-5p FGF2 0.25140374049676 0.00709934939774983 -0.310412510487203 1.0531264899139e-05 MirTarget;miRNATAP -0.137720507275413 5.34564200507529e-06 NA NA NA hsa-miR-450b-5p FGF2 0.270544879013992 0.00801537838499562 -0.310412510487203 1.0531264899139e-05 mirMAP -0.1181608495248 1.10414336833114e-05 NA NA NA hsa-miR-92a-3p FGF2 0.0407239381334659 0.643983393805961 -0.310412510487203 1.0531264899139e-05 miRNAWalker2_validate -0.244288015297521 5.53502580269543e-07 NA NA NA hsa-miR-93-3p FGF2 0.0778767956494004 0.272224943247293 -0.310412510487203 1.0531264899139e-05 mirMAP -0.195143626431712 9.46174309952938e-07 NA NA NA hsa-miR-320a FGF7 0.092135599636725 0.243028758989929 -0.109502517174931 0.0871753790241782 miRanda -0.189627649950838 1.75375340223191e-05 NA NA NA hsa-miR-142-3p FGF9 0.558908907203977 1.37828834702416e-05 -0.595722923032546 5.09639453585729e-05 miRanda -0.282659516489835 3.27499478623632e-08 NA NA NA hsa-miR-142-5p FGF9 0.434884875454107 0.000575570345702788 -0.595722923032546 5.09639453585729e-05 mirMAP -0.263556678906143 1.6968256051013e-07 NA NA NA hsa-miR-155-5p FGF9 0.969837380981085 5.86551495710056e-15 -0.595722923032546 5.09639453585729e-05 miRNATAP -0.453780730649256 1.65025963862586e-20 NA NA NA hsa-miR-15a-5p FGF9 0.142658985373611 0.0536219185009004 -0.595722923032546 5.09639453585729e-05 miRNATAP -0.275420422702668 0.00935039740726957 NA NA NA hsa-miR-15b-5p FGF9 0.592863156692837 1.41971517354055e-10 -0.595722923032546 5.09639453585729e-05 miRNATAP -0.404611884080866 2.58313582119002e-08 NA NA NA hsa-miR-186-5p FGF9 0.0606381894130505 0.514217717592464 -0.595722923032546 5.09639453585729e-05 mirMAP -0.250823884564551 0.00106977407353773 NA NA NA hsa-miR-195-3p FGF9 0.100105455903079 0.133362389112338 -0.595722923032546 5.09639453585729e-05 mirMAP;miRNATAP -0.574940764738145 5.84660729823155e-09 NA NA NA hsa-miR-195-5p FGF9 -0.00728332132631593 0.92969850577609 -0.595722923032546 5.09639453585729e-05 miRNATAP -0.24382643607404 0.00409105332090611 NA NA NA hsa-miR-30a-3p FGF9 0.0655410309550977 0.509541256241954 -0.595722923032546 5.09639453585729e-05 mirMAP -0.555169048587157 2.90091683073997e-11 NA NA NA hsa-miR-30d-3p FGF9 0.0854049347792898 0.20691254801121 -0.595722923032546 5.09639453585729e-05 mirMAP -0.289322511444801 0.00271338910608715 NA NA NA hsa-miR-30e-3p FGF9 0.00173769765874887 0.984965501547409 -0.595722923032546 5.09639453585729e-05 mirMAP -0.277338182293572 0.00386198649418057 NA NA NA hsa-miR-320a FGF9 0.092135599636725 0.243028758989929 -0.595722923032546 5.09639453585729e-05 mirMAP;miRNATAP -0.59157746030768 5.35123905548572e-09 NA NA NA hsa-miR-320b FGF9 0.283477746304177 0.0005953763020907 -0.595722923032546 5.09639453585729e-05 mirMAP;miRNATAP -0.390562222089067 4.68249121043252e-07 NA NA NA hsa-miR-320c FGF9 0.343259124189966 0.000248338401291051 -0.595722923032546 5.09639453585729e-05 mirMAP;miRNATAP -0.476602977693011 7.45109251212317e-12 NA NA NA hsa-miR-374a-5p FGF9 0.0121037060909277 0.865417963345881 -0.595722923032546 5.09639453585729e-05 mirMAP -0.347418722893837 0.000370519855560241 NA NA NA hsa-miR-424-5p FGF9 0.25140374049676 0.00709934939774983 -0.595722923032546 5.09639453585729e-05 miRNATAP -0.323788407456984 7.04548719212049e-06 NA NA NA hsa-miR-450b-5p FGF9 0.270544879013992 0.00801537838499562 -0.595722923032546 5.09639453585729e-05 mirMAP;miRNATAP -0.170139909599057 0.00822509033990335 NA NA NA hsa-miR-455-5p FGF9 0.332224239762 0.0106491358056238 -0.595722923032546 5.09639453585729e-05 miRanda -0.20501240822684 3.46032555683183e-05 NA NA NA hsa-miR-500a-5p FGF9 0.0634452729978863 0.396072382601677 -0.595722923032546 5.09639453585729e-05 miRNATAP -0.343027613737247 7.65451782761426e-05 NA NA NA hsa-miR-501-3p FGF9 0.0726267165568464 0.382729320534971 -0.595722923032546 5.09639453585729e-05 miRNATAP -0.362505345443718 6.76645261427266e-06 NA NA NA hsa-miR-502-3p FGF9 0.0276791089364088 0.697605011368848 -0.595722923032546 5.09639453585729e-05 miRNATAP -0.337427005191369 0.000251687937385934 NA NA NA hsa-miR-548b-3p FGF9 0.340474544210108 0.00224491592019745 -0.595722923032546 5.09639453585729e-05 PITA;miRNATAP -0.216483740417717 0.000218504203688734 NA NA NA hsa-miR-590-3p FGF9 0.312951515438396 0.000480455423843996 -0.595722923032546 5.09639453585729e-05 miRanda;mirMAP -0.361438804031195 4.29572281799449e-07 NA NA NA hsa-miR-590-5p FGF9 0.16946027035949 0.0386004382081678 -0.595722923032546 5.09639453585729e-05 miRanda -0.321536756569473 5.33163773528782e-05 NA NA NA hsa-miR-106b-5p FGFR1 0.167096183547615 0.0497544396383451 0.192963212582154 0.0114476358485445 mirMAP -0.131235051348832 0.00142331370486675 NA NA NA hsa-miR-135a-5p FGFR1 -0.122734612943241 0.196985964641886 0.192963212582154 0.0114476358485445 mirMAP -0.267076393133823 3.49512278163343e-16 NA NA NA hsa-miR-17-5p FGFR1 0.0975751369167082 0.20621110214601 0.192963212582154 0.0114476358485445 mirMAP -0.17274697976655 0.000506163795302763 NA NA NA hsa-miR-20a-5p FGFR1 -0.0115865752288853 0.887069448776018 0.192963212582154 0.0114476358485445 mirMAP -0.126433668888031 0.00557452572524836 NA NA NA hsa-miR-301a-3p FGFR1 0.00956875714542704 0.916380325220259 0.192963212582154 0.0114476358485445 mirMAP -0.276045190623239 1.48240939059687e-15 NA NA NA hsa-miR-3065-5p FGFR1 -0.262608140481507 0.0414570974148034 0.192963212582154 0.0114476358485445 mirMAP -0.16049264076124 1.15527531166031e-11 NA NA NA hsa-miR-19b-1-5p FGFR2 0.0686579042235509 0.332645627997485 -0.492577222868217 7.16897440371588e-05 miRNAWalker2_validate;miRTarBase -0.219237513523795 0.00418312265430993 NA NA NA hsa-miR-767-3p FGFR2 -0.429854368420513 0.000821445291167688 -0.492577222868217 7.16897440371588e-05 miRNATAP -0.194318397286558 3.97094001404658e-06 NA NA NA hsa-miR-19a-3p FGFR3 0.0466707843731911 0.576818938277755 -0.365042106979193 0.0162579686859603 mirMAP -0.403607035817958 7.63620881302308e-07 NA NA NA hsa-miR-19b-3p FGFR3 -0.0138427450847924 0.856506310673067 -0.365042106979193 0.0162579686859603 mirMAP -0.493984491016398 3.76125674952932e-07 NA NA NA hsa-miR-423-5p FGFR3 0.0965587900813789 0.148039180704338 -0.365042106979193 0.0162579686859603 MirTarget -0.461369327046826 2.91582172960651e-05 NA NA NA hsa-miR-326 FGFR4 -0.631050656251074 8.83643450601471e-05 -0.113755549365812 0.272566172396588 miRanda;miRNATAP -0.114644354916499 3.71049779113221e-05 NA NA NA hsa-miR-330-5p FGFR4 -0.262932095995605 0.0465226565966658 -0.113755549365812 0.272566172396588 miRanda;miRNATAP -0.162111818201426 2.05395711443048e-06 NA NA NA hsa-miR-491-5p FGFR4 -0.749881113074983 8.22859263179194e-09 -0.113755549365812 0.272566172396588 miRanda -0.122513697865613 0.000325785696471828 NA NA NA hsa-miR-7-5p FLNA -0.244254069762734 0.193173919522103 0.482656529265684 3.91481585934668e-07 miRNAWalker2_validate -0.134957527393108 9.30943416873876e-12 NA NA NA hsa-miR-582-3p FLNB -0.11807589183011 0.304077332003677 -0.141802668945022 0.0330837088685682 mirMAP -0.138199411308273 6.98805669998941e-11 NA NA NA hsa-miR-9-5p FLNB -0.125377971246422 0.269896477802284 -0.141802668945022 0.0330837088685682 miRNAWalker2_validate -0.224191909555309 2.13967461257299e-05 NA NA NA hsa-miR-592 FLNC 0.0170005651576508 0.876633091134809 0.766875925525887 3.34944807114331e-06 mirMAP -0.323850898764672 8.58633085633026e-07 NA NA NA hsa-miR-139-5p FOS -0.647754756897633 2.15378307237163e-06 0.540206154761091 0.0003674726518619 miRNAWalker2_validate;miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.16678562795059 0.000514206834610942 23001723 Derepression of c Fos caused by microRNA 139 down regulation contributes to the metastasis of human hepatocellular carcinoma; This study investigates whether the anti-metastasis effect of microRNA-139 miR-139 on hepatocellular carcinoma HCC is mediated through regulating c-fos expression; The expression levels of miR-139 and c-fos in human HCC cell sublines with high MHCC97H and low MHCC97L spontaneous metastatic potentials were quantified using QPCR or Western blot; The effect of overexpression or down-expression of miR-139 on c-fos expression of MHCC97H and MHCC97L cells was evaluated using QPCR and Western blot; The 3' untranslated region segments of FOS containing the miR-139 binding sites were amplified by PCR and the luciferase activity in the transfected cells was assayed; In comparison with the expression level of miR-139 in MHCC97L cells the expression level in MHCC97H cells was significantly decreased whereas c-Fos was significantly up-regulated in MHCC97H; The overexpression of miR-139 significantly inhibited the expression of c-fos in MHCC97H cells and the down-expression of miR-139 significantly promoted the expression of c-fos in MHCC97L cells; In vitro cell migration analysis demonstrated that depletion of c-fos or overexpression of miR-139 in MHCC97H cells reduced cell migration whereas overexpression of c-fos or depletion of miR-139 in MHCC97L cells increased cell migration; Derepression of c-Fos caused by miR-139 down-regulation contributes to the metastasis of HCC metastasis;cell migration liver cancer hsa-miR-767-5p FOS -0.551653504513145 2.61109058244854e-05 0.540206154761091 0.0003674726518619 miRNATAP -0.183849714684089 0.000188534669326726 NA NA NA hsa-miR-129-5p GADD45A -0.567133990117126 0.00116152215679936 0.578892696032557 1.73109905217762e-08 miRanda -0.117655587237976 4.85565235622386e-06 NA NA NA hsa-miR-504-5p GADD45A -0.510726779625117 6.12122269907368e-05 0.578892696032557 1.73109905217762e-08 miRNAWalker2_validate -0.168708037304693 1.35009592733874e-06 NA NA NA hsa-miR-767-3p GADD45B -0.429854368420513 0.000821445291167688 0.336709257563835 0.00421134915835084 miRNATAP -0.202993831911469 2.25161118087796e-07 NA NA NA hsa-miR-107 GADD45G -0.121070851008387 0.198381281894242 -0.285061728022188 0.0219160171580943 miRanda -0.395129731583354 1.47199359369081e-11 NA NA NA hsa-miR-127-3p GADD45G -0.164565333886312 0.2710118155902 -0.285061728022188 0.0219160171580943 miRanda;miRNATAP -0.22122061367908 1.46503376303966e-09 NA NA NA hsa-miR-1468-5p GADD45G -0.00455857880561572 0.960319769044627 -0.285061728022188 0.0219160171580943 MirTarget -0.287534063688522 5.82428979745539e-07 NA NA NA hsa-miR-1976 GADD45G 0.127074435034705 0.277235601775457 -0.285061728022188 0.0219160171580943 MirTarget -0.288291002566395 7.11683611697151e-11 NA NA NA hsa-miR-186-5p GNA12 0.0606381894130505 0.514217717592464 0.0382998581418947 0.514148423682221 mirMAP -0.104991427944591 1.38926057796408e-06 NA NA NA hsa-miR-767-3p GNG12 -0.429854368420513 0.000821445291167688 0.604079373560736 2.54919131069303e-06 PITA -0.404877496894133 3.81038934768308e-21 NA NA NA hsa-miR-96-5p GNG12 -0.217255611810229 0.209932800103896 0.604079373560736 2.54919131069303e-06 TargetScan -0.15058114761266 3.24333049347937e-06 NA NA NA hsa-let-7b-5p HRAS 0.036218385218298 0.719557004564478 -0.0696529935819452 0.235865730348535 miRTarBase -0.105421362575589 0.000967581673758039 20607356;20881268;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;On the basis of these data we suggest that the downregulation of let-7b and let-7e targeting K-ras and the upregulation of miR-17* a CRC marker could be considered as candidate molecular markers of cetuximab resistance;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;drug resistance;;;progression glioblastoma;colorectal cancer;lung cancer;lung cancer;pancreatic cancer hsa-miR-181d-5p HRAS -0.0746131973223108 0.331281641674538 -0.0696529935819452 0.235865730348535 miRNAWalker2_validate;miRTarBase -0.133860130747548 5.02157599075857e-05 NA NA NA hsa-miR-450b-5p HSPA2 0.270544879013992 0.00801537838499562 -0.475049378345164 0.000277282851333299 miRNATAP -0.192122462492855 0.000501607536892953 NA NA NA hsa-miR-577 HSPB1 -0.382068371859275 0.0145513192729119 0.526807327159886 7.72626999801002e-07 PITA -0.126253280760655 1.43369150075721e-05 NA NA NA hsa-miR-139-5p IKBKB -0.647754756897633 2.15378307237163e-06 0.113293458902771 0.0150457519384782 miRanda -0.130032749382716 1.65206176469125e-33 NA NA NA hsa-miR-491-5p IKBKB -0.749881113074983 8.22859263179194e-09 0.113293458902771 0.0150457519384782 miRanda -0.106383336993955 5.8305133961577e-22 NA NA NA hsa-miR-139-5p JUN -0.647754756897633 2.15378307237163e-06 0.37954584650033 7.46220464317962e-05 MirTarget;PITA;miRanda;miRNATAP -0.185022658773887 2.83059205114288e-11 25499265 In this study we report the identification of a novel negative feedback loop formed between miR-139 and its oncogenic target Jun; In this loop miR-139 could inhibit Jun expression by targeting a conserved site on its 3'-UTR whereas Jun could induce miR-139 expression in a dose dependent manner through a distant upstream regulatory element; Interestingly aberration in this loop was found in human gastric cancer where miR-139 was down-regulated and inversely correlated with Jun expression; Further functional analysis showed that restored expression of miR-139 in gastric cancer cells significantly induces apoptosis and inhibits cell migration and proliferation as well as tumour growth through targeting Jun; Given that miR-139 and Jun are deregulated in many cancers our findings here might have broader implication in other types of human cancers cell migration gastric cancer hsa-let-7a-3p KRAS 0.0530563276543763 0.370749834463566 -0.0976184278638819 0.0473238165779176 mirMAP;miRNATAP -0.163441029301714 2.66738583745088e-07 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-miR-30b-5p KRAS -0.0858101016322106 0.263243418521854 -0.0976184278638819 0.0473238165779176 mirMAP;miRNATAP -0.131312331179891 6.91058885171462e-07 NA NA NA hsa-let-7b-5p MAP2K2 0.036218385218298 0.719557004564478 0.0338816015099894 0.511977780289519 miRNAWalker2_validate -0.156288464298574 5.22052349984698e-12 NA NA NA hsa-miR-9-5p MAP2K3 -0.125377971246422 0.269896477802284 0.44249890960848 9.70578230646814e-13 miRNATAP -0.663089933937009 1.27240483431571e-35 NA NA NA hsa-miR-27a-3p MAP2K4 0.303760032895792 0.00457375391189806 -0.185942621661578 0.00255972396448771 miRNATAP -0.127230299688305 1.11343075615381e-07 27594411;24556602 Androgen induced miR 27A acted as a tumor suppressor by targeting MAP2K4 and mediated prostate cancer progression;MicroRNA 27a promotes proliferation migration and invasion by targeting MAP2K4 in human osteosarcoma cells; In this study three biological programs were used to predict whether MAP2K4 was a target of miR-27a; Thus MAP2K4 is a potential target of miR-27a and can be directly regulated by miR-27a; After transfection of the miR-27a inhibitor into the MG63 cells the level of phospho-JNK1 and phospho-p38 increased by 25% and 29% respectively along with the up-regulation of MAP2K4 protein; This is the first study showing that miR-27a can function as an oncogene by targeting MAP2K4 in the osteosarcoma MG63 cell line; Inhibition of miR-27a increases MAP2K4 expression which in turn inhibits cell proliferation and migration through the JNK/p38 signaling pathway in MG63 cells progression; prostate cancer;sarcoma hsa-miR-3065-3p MAP2K4 -0.261348288537884 0.0343753235107924 -0.185942621661578 0.00255972396448771 miRNATAP -0.146904879184971 1.46091633638265e-13 NA NA NA hsa-miR-3065-5p MAP2K4 -0.262608140481507 0.0414570974148034 -0.185942621661578 0.00255972396448771 miRNATAP -0.128240196576007 2.5031664461957e-12 NA NA NA hsa-miR-30a-5p MAP2K4 -0.062942936611238 0.513851954700252 -0.185942621661578 0.00255972396448771 miRNATAP -0.136805953642661 0.000866480757525279 NA NA NA hsa-miR-374a-3p MAP2K4 0.176226170437625 0.0343958848425446 -0.185942621661578 0.00255972396448771 mirMAP -0.173585844310507 1.14454009445663e-06 NA NA NA hsa-miR-576-5p MAP2K4 0.106482276040047 0.194379152564166 -0.185942621661578 0.00255972396448771 PITA -0.115541334056967 9.18172636227802e-05 NA NA NA hsa-miR-92b-3p MAP2K4 -0.213968504161963 0.0523921855715716 -0.185942621661578 0.00255972396448771 miRNATAP -0.126622991843834 4.57920831025069e-07 NA NA NA hsa-miR-145-5p MAP2K6 0.108948399943015 0.310032352776693 -0.0560784740258802 0.279685335420792 miRNAWalker2_validate -0.108962168237135 4.358248566082e-07 NA NA NA hsa-miR-342-3p MAP2K6 -0.125683829770877 0.105810751640137 -0.0560784740258802 0.279685335420792 miRanda -0.118996961608483 0.000179097470984804 NA NA NA hsa-miR-139-5p MAP3K1 -0.647754756897633 2.15378307237163e-06 0.465982467733829 9.39781183613041e-11 miRanda -0.141771163672676 3.18554143822605e-10 NA NA NA hsa-miR-30a-5p MAP3K1 -0.062942936611238 0.513851954700252 0.465982467733829 9.39781183613041e-11 miRNATAP -0.231350398199611 8.14670758562291e-06 NA NA NA hsa-miR-338-3p MAP3K1 -0.39963704679384 0.0034410643220691 0.465982467733829 9.39781183613041e-11 miRanda -0.128741986293352 9.99541924046903e-08 NA NA NA hsa-miR-9-5p MAP3K1 -0.125377971246422 0.269896477802284 0.465982467733829 9.39781183613041e-11 miRNATAP -0.296013347074583 8.11254993708187e-06 NA NA NA hsa-miR-186-5p MAP3K12 0.0606381894130505 0.514217717592464 -0.10192023499684 0.0371585308808533 MirTarget -0.110579923024597 3.96013631474518e-08 NA NA NA hsa-miR-30e-5p MAP3K12 0.0764521828640934 0.41904991629622 -0.10192023499684 0.0371585308808533 MirTarget -0.101667764759116 6.52209769722442e-05 NA NA NA hsa-miR-93-5p MAP3K12 0.139766237971122 0.101057320076629 -0.10192023499684 0.0371585308808533 MirTarget -0.123358044651972 6.6717675845858e-05 NA NA NA hsa-let-7a-3p MAP3K13 0.0530563276543763 0.370749834463566 -0.125198088845218 0.162411988248564 mirMAP -0.228049446339376 0.00208958122386424 NA NA NA hsa-miR-186-5p MAP3K13 0.0606381894130505 0.514217717592464 -0.125198088845218 0.162411988248564 mirMAP -0.123342485613305 0.00808288247232899 NA NA NA hsa-miR-200c-3p MAP3K13 0.413752622631695 8.6936333715621e-06 -0.125198088845218 0.162411988248564 miRNATAP -0.176629449404296 2.41325764080452e-05 NA NA NA hsa-miR-20a-3p MAP3K13 0.102743778777997 0.19677865359751 -0.125198088845218 0.162411988248564 mirMAP -0.141808856138448 0.00449938220765176 NA NA NA hsa-miR-30a-5p MAP3K13 -0.062942936611238 0.513851954700252 -0.125198088845218 0.162411988248564 MirTarget;mirMAP;miRNATAP -0.196009470758229 0.00356737799432935 NA NA NA hsa-miR-30b-5p MAP3K13 -0.0858101016322106 0.263243418521854 -0.125198088845218 0.162411988248564 MirTarget;mirMAP -0.202421049326625 0.00102145854022384 NA NA NA hsa-miR-30c-5p MAP3K13 -0.0469114469943097 0.565934557464627 -0.125198088845218 0.162411988248564 MirTarget;mirMAP;miRNATAP -0.32487644044567 1.19980355809378e-07 NA NA NA hsa-miR-320a MAP3K13 0.092135599636725 0.243028758989929 -0.125198088845218 0.162411988248564 mirMAP -0.174424528096475 0.0050664867347074 NA NA NA hsa-miR-320c MAP3K13 0.343259124189966 0.000248338401291051 -0.125198088845218 0.162411988248564 mirMAP -0.123591862352879 0.00402778725153635 NA NA NA hsa-miR-339-5p MAP3K13 0.273253751377152 0.0185300170790638 -0.125198088845218 0.162411988248564 miRanda -0.142587775795605 2.23718918677053e-05 NA NA NA hsa-miR-374a-3p MAP3K13 0.176226170437625 0.0343958848425446 -0.125198088845218 0.162411988248564 mirMAP -0.275768675771123 2.32951111846708e-06 NA NA NA hsa-miR-500a-5p MAP3K13 0.0634452729978863 0.396072382601677 -0.125198088845218 0.162411988248564 mirMAP -0.288061894153625 3.46656203089613e-08 NA NA NA hsa-miR-505-3p MAP3K13 0.115486008167472 0.109833720698312 -0.125198088845218 0.162411988248564 mirMAP -0.153166047729379 0.00767469303835138 NA NA NA hsa-miR-576-5p MAP3K13 0.106482276040047 0.194379152564166 -0.125198088845218 0.162411988248564 MirTarget -0.180887481374578 0.000182837600241882 NA NA NA hsa-miR-590-3p MAP3K13 0.312951515438396 0.000480455423843996 -0.125198088845218 0.162411988248564 miRanda;mirMAP -0.150516291012764 0.000561377508020871 NA NA NA hsa-miR-708-5p MAP3K13 -0.00936519718301376 0.919857671524527 -0.125198088845218 0.162411988248564 MirTarget;miRNATAP -0.222716047838946 1.0801076531177e-06 NA NA NA hsa-miR-93-5p MAP3K13 0.139766237971122 0.101057320076629 -0.125198088845218 0.162411988248564 miRNAWalker2_validate;miRNATAP -0.337264489973374 1.74294118003195e-06 NA NA NA hsa-miR-137 MAP3K14 -0.924849266740909 1.546832202049e-06 0.212699891188413 0.000374055421229529 MirTarget;PITA;miRanda;miRNATAP -0.111472449092906 7.99736039539788e-21 NA NA NA hsa-miR-346 MAP3K14 -0.577786425963268 2.10883270131593e-09 0.212699891188413 0.000374055421229529 miRanda -0.145514173051604 2.83732159243253e-09 NA NA NA hsa-miR-874-3p MAP3K14 -0.342846516198707 0.00227406462925841 0.212699891188413 0.000374055421229529 MirTarget -0.161463169618818 5.58488354179691e-14 NA NA NA hsa-miR-19b-3p MAP3K2 -0.0138427450847924 0.856506310673067 0.167995278754692 0.0207938025554587 MirTarget;mirMAP;miRNATAP -0.17508945622946 0.000113775877792773 NA NA NA hsa-miR-30b-5p MAP3K2 -0.0858101016322106 0.263243418521854 0.167995278754692 0.0207938025554587 mirMAP;miRNATAP -0.198973684179836 3.04221618770209e-05 NA NA NA hsa-miR-346 MAP3K2 -0.577786425963268 2.10883270131593e-09 0.167995278754692 0.0207938025554587 MirTarget;miRNATAP -0.100251640980205 0.00134878429251892 NA NA NA hsa-miR-9-5p MAP3K2 -0.125377971246422 0.269896477802284 0.167995278754692 0.0207938025554587 mirMAP;miRNATAP -0.352803543219592 9.8426907165425e-08 NA NA NA hsa-miR-9-5p MAP3K3 -0.125377971246422 0.269896477802284 0.0250337493046606 0.561151639063137 miRNAWalker2_validate;MirTarget;miRNATAP -0.177873359723304 4.1015681458846e-09 NA NA NA hsa-miR-106a-5p MAP3K5 0.110074064773897 0.13045815990621 -0.464432247100702 3.21582847203806e-10 miRNATAP -0.147979841128177 0.000509455809834157 NA NA NA hsa-miR-106b-5p MAP3K5 0.167096183547615 0.0497544396383451 -0.464432247100702 3.21582847203806e-10 miRNATAP -0.26312412963583 6.2012230940794e-12 NA NA NA hsa-miR-130a-5p MAP3K5 0.155569168973665 0.0884246261384798 -0.464432247100702 3.21582847203806e-10 miRNATAP -0.145548999700185 6.98623641116045e-06 NA NA NA hsa-miR-146b-5p MAP3K5 0.441078059667297 0.000237619929889385 -0.464432247100702 3.21582847203806e-10 miRanda -0.137174217574273 5.74214848559037e-08 NA NA NA hsa-miR-17-5p MAP3K5 0.0975751369167082 0.20621110214601 -0.464432247100702 3.21582847203806e-10 TargetScan;miRNATAP -0.351253939695795 2.29021958273375e-14 NA NA NA hsa-miR-199b-5p MAP3K5 0.436298593972862 0.00200225454383871 -0.464432247100702 3.21582847203806e-10 miRanda -0.120911343644297 2.78455619081318e-09 NA NA NA hsa-miR-20a-5p MAP3K5 -0.0115865752288853 0.887069448776018 -0.464432247100702 3.21582847203806e-10 miRNATAP -0.275668346563059 8.68091868863099e-11 NA NA NA hsa-miR-582-3p MAP3K5 -0.11807589183011 0.304077332003677 -0.464432247100702 3.21582847203806e-10 PITA;miRNATAP -0.126450337073108 1.06920207880046e-06 NA NA NA hsa-miR-582-5p MAP3K5 -0.215764335500665 0.0760892640434509 -0.464432247100702 3.21582847203806e-10 PITA;miRNATAP -0.107927245412651 5.48830368644135e-06 NA NA NA hsa-miR-590-3p MAP3K5 0.312951515438396 0.000480455423843996 -0.464432247100702 3.21582847203806e-10 miRanda -0.131291968907736 5.37484300448719e-05 NA NA NA hsa-miR-93-5p MAP3K5 0.139766237971122 0.101057320076629 -0.464432247100702 3.21582847203806e-10 miRNATAP -0.418511234597971 5.12140079614041e-16 NA NA NA hsa-let-7a-3p MAP3K8 0.0530563276543763 0.370749834463566 0.158077179723331 0.0563747887517004 MirTarget -0.184605936027976 0.00671427512812056 NA NA NA hsa-miR-128-3p MAP3K8 -0.781932174412672 7.1812756321342e-10 0.158077179723331 0.0563747887517004 MirTarget -0.135826037453442 9.23336794439461e-06 NA NA NA hsa-miR-139-5p MAP3K8 -0.647754756897633 2.15378307237163e-06 0.158077179723331 0.0563747887517004 miRanda -0.142199211828712 1.17144015055053e-07 NA NA NA hsa-let-7a-3p MAP4K3 0.0530563276543763 0.370749834463566 -0.0946523915355977 0.0296121600191617 mirMAP -0.118479063809534 6.61585248463156e-06 NA NA NA hsa-let-7d-5p MAP4K3 0.111345229817909 0.0872634398336815 -0.0946523915355977 0.0296121600191617 MirTarget;miRNATAP -0.141423959642334 8.62791312737494e-08 NA NA NA hsa-let-7d-5p MAP4K4 0.111345229817909 0.0872634398336815 -0.035044096979064 0.581227447369728 MirTarget -0.128904170993795 0.000165868363360448 NA NA NA hsa-miR-34a-5p MAP4K4 0.143472919835524 0.211283228567057 -0.035044096979064 0.581227447369728 MirTarget -0.1100794621171 2.96900637179671e-12 NA NA NA hsa-miR-361-5p MAP4K4 0.0107519600643302 0.882230614095565 -0.035044096979064 0.581227447369728 miRanda -0.107710413744494 0.000463962175721898 NA NA NA hsa-let-7a-3p MAPK1 0.0530563276543763 0.370749834463566 -0.213353498035088 0.000389157534366882 mirMAP -0.101943093753909 0.00192343923976389 NA NA NA hsa-miR-15b-5p MAPK1 0.592863156692837 1.41971517354055e-10 -0.213353498035088 0.000389157534366882 miRNAWalker2_validate -0.146191950491781 3.61739654178022e-14 NA NA NA hsa-miR-17-5p MAPK1 0.0975751369167082 0.20621110214601 -0.213353498035088 0.000389157534366882 TargetScan -0.110084866776271 7.91694183424384e-05 NA NA NA hsa-miR-19a-3p MAPK1 0.0466707843731911 0.576818938277755 -0.213353498035088 0.000389157534366882 mirMAP -0.128018489349713 2.73892272625697e-09 NA NA NA hsa-miR-19b-3p MAPK1 -0.0138427450847924 0.856506310673067 -0.213353498035088 0.000389157534366882 mirMAP -0.176138435921289 5.03823623056019e-12 NA NA NA hsa-miR-320a MAPK1 0.092135599636725 0.243028758989929 -0.213353498035088 0.000389157534366882 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.152520075612356 2.3025642938828e-08 NA NA NA hsa-miR-454-3p MAPK1 0.177318549827649 0.0120865170334418 -0.213353498035088 0.000389157534366882 mirMAP -0.118488517070993 3.52065356643667e-06 NA NA NA hsa-miR-500a-3p MAPK1 0.0479457078972052 0.49420307623914 -0.213353498035088 0.000389157534366882 mirMAP -0.108343486711378 0.000199332911985672 NA NA NA hsa-miR-130a-3p MAPK10 0.163798739071237 0.031259491216363 -0.537388523547939 4.2393247633847e-14 miRNATAP -0.146227150931435 0.000409098979829322 NA NA NA hsa-miR-130b-3p MAPK10 0.503911467685709 9.46590588950823e-08 -0.537388523547939 4.2393247633847e-14 miRNATAP -0.240966176239797 3.00288673974579e-16 NA NA NA hsa-miR-19a-3p MAPK10 0.0466707843731911 0.576818938277755 -0.537388523547939 4.2393247633847e-14 miRNATAP -0.160174316971582 5.10852507077659e-06 NA NA NA hsa-miR-19b-3p MAPK10 -0.0138427450847924 0.856506310673067 -0.537388523547939 4.2393247633847e-14 miRNATAP -0.155216608611893 0.000219766758516242 NA NA NA hsa-miR-450b-5p MAPK10 0.270544879013992 0.00801537838499562 -0.537388523547939 4.2393247633847e-14 mirMAP -0.191975437167481 2.95244540267408e-12 NA NA NA hsa-miR-454-3p MAPK10 0.177318549827649 0.0120865170334418 -0.537388523547939 4.2393247633847e-14 miRNATAP -0.177198825931711 1.91997293458149e-05 NA NA NA hsa-miR-590-3p MAPK10 0.312951515438396 0.000480455423843996 -0.537388523547939 4.2393247633847e-14 miRanda;mirMAP -0.166335972989874 8.93923250001752e-08 NA NA NA hsa-miR-590-5p MAPK10 0.16946027035949 0.0386004382081678 -0.537388523547939 4.2393247633847e-14 PITA;miRanda;miRNATAP -0.145955971255782 2.52817190707301e-05 NA NA NA hsa-miR-125a-5p MAPK12 -0.0833349424517387 0.325440200253607 -0.184333888101058 0.00516853982989052 miRNATAP -0.246707780375399 3.61083114361096e-11 NA NA NA hsa-miR-320b MAPK3 0.283477746304177 0.0005953763020907 -0.216288134544279 3.58169845564714e-05 miRNAWalker2_validate -0.103417988183093 3.03681040754152e-07 NA NA NA hsa-miR-542-3p MAPK3 0.0835995677900829 0.403838744494071 -0.216288134544279 3.58169845564714e-05 miRanda -0.133723416342879 2.41125253328141e-13 NA NA NA hsa-miR-27b-3p MAPK7 -0.0599187745243146 0.58208143475992 0.148844494454951 0.00129551732109945 miRNATAP -0.162377965389811 2.26533184573003e-23 NA NA NA hsa-miR-330-5p MAPK7 -0.262932095995605 0.0465226565966658 0.148844494454951 0.00129551732109945 miRanda -0.138962935592789 3.09643389488675e-31 NA NA NA hsa-miR-744-5p MAPK7 -0.31868579180387 0.000969037378618306 0.148844494454951 0.00129551732109945 miRNAWalker2_validate -0.205824192325797 3.35547720293884e-33 NA NA NA hsa-miR-10a-5p MAPK8 1.10332501906319 5.3831631561183e-08 -0.302931149567583 0.000188583880708274 miRNAWalker2_validate -0.120186654516686 3.43413005950355e-13 NA NA NA hsa-miR-16-2-3p MAPK8 0.468816222075619 7.04377763166292e-05 -0.302931149567583 0.000188583880708274 mirMAP -0.102102855430457 0.000418952571359225 NA NA NA hsa-miR-22-5p MAPK8 0.0437233965539527 0.639996108995995 -0.302931149567583 0.000188583880708274 mirMAP -0.175094083929253 2.69922381021858e-06 NA NA NA hsa-miR-30a-5p MAPK8 -0.062942936611238 0.513851954700252 -0.302931149567583 0.000188583880708274 mirMAP -0.407693291423913 2.44429012802795e-12 NA NA NA hsa-miR-30b-5p MAPK8 -0.0858101016322106 0.263243418521854 -0.302931149567583 0.000188583880708274 mirMAP -0.161604562972212 0.00297088085323934 NA NA NA hsa-miR-30c-5p MAPK8 -0.0469114469943097 0.565934557464627 -0.302931149567583 0.000188583880708274 mirMAP -0.352021480256678 5.75202015716757e-11 NA NA NA hsa-miR-374a-3p MAPK8 0.176226170437625 0.0343958848425446 -0.302931149567583 0.000188583880708274 mirMAP -0.233850674687013 5.69445641069691e-06 NA NA NA hsa-miR-590-3p MAPK8 0.312951515438396 0.000480455423843996 -0.302931149567583 0.000188583880708274 miRNATAP -0.178854419631098 3.01021919217562e-06 NA NA NA hsa-miR-125a-3p MAPK8IP2 0.183834985432376 0.106230647107917 -0.557952378365906 1.88795018982421e-08 miRanda -0.162623830786618 1.02447152233423e-05 NA NA NA hsa-miR-130a-3p MAPK8IP2 0.163798739071237 0.031259491216363 -0.557952378365906 1.88795018982421e-08 mirMAP -0.219628037349315 0.000332225766822979 NA NA NA hsa-miR-130b-3p MAPK8IP2 0.503911467685709 9.46590588950823e-08 -0.557952378365906 1.88795018982421e-08 mirMAP -0.228630392086339 2.69842356501222e-07 NA NA NA hsa-miR-141-3p MAPK8IP2 0.41120561991992 0.000393344390969055 -0.557952378365906 1.88795018982421e-08 mirMAP -0.210343700098179 5.53252292878734e-09 NA NA NA hsa-miR-15a-5p MAPK8IP2 0.142658985373611 0.0536219185009004 -0.557952378365906 1.88795018982421e-08 mirMAP -0.199258670159946 0.00350667332390403 NA NA NA hsa-miR-15b-5p MAPK8IP2 0.592863156692837 1.41971517354055e-10 -0.557952378365906 1.88795018982421e-08 mirMAP -0.293847696822355 3.00491909307219e-10 NA NA NA hsa-miR-16-5p MAPK8IP2 0.246024668671282 0.00346042804503716 -0.557952378365906 1.88795018982421e-08 mirMAP -0.167095585129854 0.00431763835477018 NA NA NA hsa-miR-24-3p MAPK8IP2 0.133257261462871 0.212960921400853 -0.557952378365906 1.88795018982421e-08 mirMAP -0.210815012275852 9.23023426507997e-07 NA NA NA hsa-miR-301a-3p MAPK8IP2 0.00956875714542704 0.916380325220259 -0.557952378365906 1.88795018982421e-08 mirMAP -0.258512562016385 4.90574656864298e-08 NA NA NA hsa-miR-32-5p MAPK8IP2 0.130313603388223 0.177843055266148 -0.557952378365906 1.88795018982421e-08 mirMAP -0.243391900083091 2.1190074496948e-08 NA NA NA hsa-miR-423-5p MAPK8IP2 0.0965587900813789 0.148039180704338 -0.557952378365906 1.88795018982421e-08 mirMAP -0.20994668640465 0.0028724313155406 NA NA NA hsa-miR-424-5p MAPK8IP2 0.25140374049676 0.00709934939774983 -0.557952378365906 1.88795018982421e-08 mirMAP -0.242281849024138 1.67095148772247e-07 NA NA NA hsa-miR-454-3p MAPK8IP2 0.177318549827649 0.0120865170334418 -0.557952378365906 1.88795018982421e-08 mirMAP -0.181370675059541 0.00324408615952723 NA NA NA hsa-miR-542-3p MAPK8IP2 0.0835995677900829 0.403838744494071 -0.557952378365906 1.88795018982421e-08 mirMAP -0.22268259317417 1.16157881391956e-06 NA NA NA hsa-miR-1262 MAPK8IP3 0.276259331706731 0.0259799942226561 -0.249753963448146 6.86298790707653e-05 mirMAP -0.133423830610018 3.50175596533e-15 NA NA NA hsa-miR-27a-3p MAPK8IP3 0.303760032895792 0.00457375391189806 -0.249753963448146 6.86298790707653e-05 miRNATAP -0.175969095898143 2.20088832819673e-17 NA NA NA hsa-miR-320b MAPK8IP3 0.283477746304177 0.0005953763020907 -0.249753963448146 6.86298790707653e-05 MirTarget;PITA;miRanda;miRNATAP -0.132292482940494 1.82262029031283e-07 NA NA NA hsa-miR-320c MAPK8IP3 0.343259124189966 0.000248338401291051 -0.249753963448146 6.86298790707653e-05 MirTarget;PITA;miRanda;miRNATAP -0.159460963857409 2.47804670536665e-12 NA NA NA hsa-miR-362-3p MAPK8IP3 0.032375035235532 0.736465332563774 -0.249753963448146 6.86298790707653e-05 miRanda -0.10109583202737 4.04676973313152e-06 NA NA NA hsa-let-7i-5p MAPK9 0.0952853587923244 0.192120688957249 -0.250992535130042 2.41271995485752e-05 miRNATAP -0.111926815056819 0.00309462880153316 NA NA NA hsa-miR-106b-5p MAPK9 0.167096183547615 0.0497544396383451 -0.250992535130042 2.41271995485752e-05 miRNAWalker2_validate;miRNATAP -0.10590505262462 0.000236784602878243 NA NA NA hsa-miR-320a MAPK9 0.092135599636725 0.243028758989929 -0.250992535130042 2.41271995485752e-05 miRanda;miRNATAP -0.209587243417478 6.52556108505869e-10 NA NA NA hsa-miR-320b MAPK9 0.283477746304177 0.0005953763020907 -0.250992535130042 2.41271995485752e-05 miRanda;miRNATAP -0.150322035936768 6.40324029911169e-09 NA NA NA hsa-miR-320c MAPK9 0.343259124189966 0.000248338401291051 -0.250992535130042 2.41271995485752e-05 miRanda;miRNATAP -0.160739998379643 5.6021711014594e-12 NA NA NA hsa-miR-542-3p MAPK9 0.0835995677900829 0.403838744494071 -0.250992535130042 2.41271995485752e-05 miRanda -0.120047809070845 4.59691685311462e-07 NA NA NA hsa-miR-93-5p MAPK9 0.139766237971122 0.101057320076629 -0.250992535130042 2.41271995485752e-05 miRNAWalker2_validate;miRNATAP -0.21497342781919 3.19876665049407e-08 NA NA NA hsa-miR-124-3p MAPKAPK2 -0.506026514549291 0.0078056370358648 0.197884443595911 0.000243637469653919 miRNAWalker2_validate -0.104193214862002 1.11355518201979e-30 NA NA NA hsa-miR-129-2-3p MAPKAPK2 -0.6175132197013 0.000561573620904867 0.197884443595911 0.000243637469653919 mirMAP -0.104836723140721 9.64833201965142e-28 NA NA NA hsa-miR-485-3p MAPKAPK2 -0.530677478972593 0.00148549219838911 0.197884443595911 0.000243637469653919 MirTarget;PITA;miRNATAP -0.100951350110281 2.35175125442569e-22 NA NA NA hsa-miR-9-5p MAPKAPK2 -0.125377971246422 0.269896477802284 0.197884443595911 0.000243637469653919 miRNATAP -0.247223486381394 3.27193806699658e-10 NA NA NA hsa-miR-128-3p MAPKAPK3 -0.781932174412672 7.1812756321342e-10 0.0666408822263467 0.280567270992267 MirTarget -0.131034188481023 8.75519753669743e-11 NA NA NA hsa-miR-10a-5p MAPT 1.10332501906319 5.3831631561183e-08 -0.364140145327561 1.43181792353602e-05 mirMAP -0.169151257492724 3.7889177386439e-37 NA NA NA hsa-miR-1262 MAPT 0.276259331706731 0.0259799942226561 -0.364140145327561 1.43181792353602e-05 mirMAP -0.136400844126949 8.98800298612629e-09 NA NA NA hsa-miR-146b-3p MAPT 0.283486177568242 0.0118918188864879 -0.364140145327561 1.43181792353602e-05 miRNATAP -0.237161891190495 1.23732801296377e-20 NA NA NA hsa-miR-146b-5p MAPT 0.441078059667297 0.000237619929889385 -0.364140145327561 1.43181792353602e-05 PITA;miRNATAP -0.263615983903965 1.39528914953864e-27 NA NA NA hsa-miR-148b-5p MAPT 0.127111784487801 0.188731110216917 -0.364140145327561 1.43181792353602e-05 mirMAP -0.190881216203535 2.72497460875203e-10 NA NA NA hsa-miR-150-5p MAPT 0.0645271721519611 0.513295658828718 -0.364140145327561 1.43181792353602e-05 mirMAP -0.132641003486002 1.49691183584544e-05 NA NA NA hsa-miR-217 MAPT 0.540279882451941 0.00312206944061206 -0.364140145327561 1.43181792353602e-05 mirMAP -0.12176466539823 4.6341914138802e-15 NA NA NA hsa-miR-2355-3p MAPT 0.186207523505296 0.0525918026993012 -0.364140145327561 1.43181792353602e-05 miRNATAP -0.194961498048209 6.3870168038393e-11 NA NA NA hsa-miR-24-3p MAPT 0.133257261462871 0.212960921400853 -0.364140145327561 1.43181792353602e-05 mirMAP -0.217095815313307 2.79588853876135e-13 NA NA NA hsa-miR-27a-3p MAPT 0.303760032895792 0.00457375391189806 -0.364140145327561 1.43181792353602e-05 miRNATAP -0.268636068918412 3.25837341562944e-21 NA NA NA hsa-miR-27b-3p MAPT -0.0599187745243146 0.58208143475992 -0.364140145327561 1.43181792353602e-05 miRNATAP -0.153645472619276 1.80165302266269e-07 NA NA NA hsa-miR-27b-5p MAPT 0.224282840351546 0.00630787296051719 -0.364140145327561 1.43181792353602e-05 mirMAP -0.352424940856133 5.10630503732235e-25 NA NA NA hsa-miR-28-5p MAPT 0.104003572105781 0.153594705579534 -0.364140145327561 1.43181792353602e-05 mirMAP -0.293359783961987 5.0332056418157e-12 NA NA NA hsa-miR-30a-3p MAPT 0.0655410309550977 0.509541256241954 -0.364140145327561 1.43181792353602e-05 mirMAP -0.243217774752154 1.23079673246698e-10 NA NA NA hsa-miR-30e-3p MAPT 0.00173769765874887 0.984965501547409 -0.364140145327561 1.43181792353602e-05 mirMAP -0.203260623782369 2.43328351804092e-06 NA NA NA hsa-miR-320a MAPT 0.092135599636725 0.243028758989929 -0.364140145327561 1.43181792353602e-05 miRanda -0.14993824007826 0.00121829562347198 NA NA NA hsa-miR-320b MAPT 0.283477746304177 0.0005953763020907 -0.364140145327561 1.43181792353602e-05 miRanda -0.163917579747158 3.03060673461862e-06 NA NA NA hsa-miR-320c MAPT 0.343259124189966 0.000248338401291051 -0.364140145327561 1.43181792353602e-05 miRanda -0.188116877318064 2.757148067555e-09 NA NA NA hsa-miR-335-5p MAPT 0.0938511632756978 0.336889056387694 -0.364140145327561 1.43181792353602e-05 mirMAP -0.134435626817959 9.56470897278462e-06 NA NA NA hsa-miR-342-3p MAPT -0.125683829770877 0.105810751640137 -0.364140145327561 1.43181792353602e-05 MirTarget;miRanda -0.130617481400869 0.00197924455129185 NA NA NA hsa-miR-34a-5p MAPT 0.143472919835524 0.211283228567057 -0.364140145327561 1.43181792353602e-05 MirTarget;miRNATAP -0.285639532313826 4.28840677937924e-31 NA NA NA hsa-miR-34c-5p MAPT 0.181931113688093 0.257266965617363 -0.364140145327561 1.43181792353602e-05 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.148906322487251 1.68716664125969e-17 23423488 Luciferase activity assay confirmed that the 3'-UTR of MAPT mRNA contains a functional miR-34c-5p binding site; Overexpression of miR-34c-5p significantly downregulated MAPT protein expression and increased the chemosensitivity of paclitaxel-resistant gastric cancer cells; DNA methylation dysregulation of miR-34c-5p and MAPT expression are critical factors in the chemoresistance of gastric cancer to paclitaxel drug resistance gastric cancer hsa-miR-361-5p MAPT 0.0107519600643302 0.882230614095565 -0.364140145327561 1.43181792353602e-05 miRanda -0.213148106163957 1.90868246013616e-05 NA NA NA hsa-miR-362-3p MAPT 0.032375035235532 0.736465332563774 -0.364140145327561 1.43181792353602e-05 MirTarget -0.201311143592577 1.79417062822762e-11 NA NA NA hsa-miR-450b-5p MAPT 0.270544879013992 0.00801537838499562 -0.364140145327561 1.43181792353602e-05 mirMAP -0.158154300272933 3.96275919860196e-08 NA NA NA hsa-miR-484 MAPT -0.0190828819137732 0.802298900989652 -0.364140145327561 1.43181792353602e-05 mirMAP -0.223389236608883 4.38970144199819e-08 NA NA NA hsa-miR-505-5p MAPT 0.0973008785018434 0.183209581426791 -0.364140145327561 1.43181792353602e-05 MirTarget -0.166280390805695 3.9276287071291e-05 NA NA NA hsa-miR-548b-3p MAPT 0.340474544210108 0.00224491592019745 -0.364140145327561 1.43181792353602e-05 mirMAP -0.238869910770734 9.89918867792289e-21 NA NA NA hsa-miR-589-5p MAPT -0.0382528919634639 0.5844074434222 -0.364140145327561 1.43181792353602e-05 mirMAP -0.188352510957512 0.000104625997260266 NA NA NA hsa-miR-320a MEF2C 0.092135599636725 0.243028758989929 -0.166420430523041 0.0845020128897844 miRanda -0.346422128394759 3.81079802316126e-08 NA NA NA hsa-miR-9-5p MEF2C -0.125377971246422 0.269896477802284 -0.166420430523041 0.0845020128897844 MirTarget;miRNATAP -0.317028058516429 0.000307074492071552 NA NA NA hsa-miR-9-5p MKNK2 -0.125377971246422 0.269896477802284 0.105338826545263 0.0522952737175776 mirMAP -0.328200714163469 6.6054988999629e-16 NA NA NA hsa-miR-130b-5p MRAS 0.413070888963592 1.98866876365509e-06 -0.233931717638168 0.000196961048861355 mirMAP -0.210777239663277 5.68474950478573e-16 NA NA NA hsa-miR-423-5p MRAS 0.0965587900813789 0.148039180704338 -0.233931717638168 0.000196961048861355 miRNATAP -0.138926888377593 0.000258546948619713 NA NA NA hsa-let-7c-5p MYC -0.04295851886768 0.676052842748691 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.187493318710893 0.00114816000552179 22128178 MicroRNA let 7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells prostate cancer hsa-let-7f-5p MYC 0.0508269185845673 0.62677515045793 0.0342990533418108 0.742963156666191 miRNAWalker2_validate -0.234906036376788 1.38501616912732e-05 NA NA NA hsa-let-7g-5p MYC -0.0253396334608382 0.742556489443668 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.402035322238661 2.54889860814805e-08 NA NA NA hsa-miR-145-5p MYC 0.108948399943015 0.310032352776693 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.26620175812587 1.77011092539307e-10 23919393;21836381;23499891;24356567;21092188;21690566;21723890;27482839 MicroRNA 145 function as a cell growth repressor by directly targeting c Myc in human ovarian cancer; We show that miR-145 directly target the c-Myc 3'-UTR; Moreover ectopic expression of c-Myc reduces the inhibition of cell proliferation caused by miR-145 transfection; Cell cycle assay showed that up-regulation of miR-145 reduces S phase population and restoration of c-Myc can rescue this reduction; These findings indicate that miR-145 inhibits cell proliferation and promotes cell apoptosis by targeting c-Myc 3'-UTR;The ectopic expression of miR-145 showed a significant growth inhibition in both canine and human melanoma cells tested and the effect was achieved partly by suppressing c-MYC in canine melanoma LMeC and in human melanoma A2058 and Mewo cells;The ectopic expression of miR-145 inhibited the growth of DLD-1 cells by disturbing β-catenin translocation into the nucleus thereby leading to the down-regulation of LEF/TCF transcriptional target genes c-Myc and CyclinD1;miR 145 inhibits proliferation and invasion of esophageal squamous cell carcinoma in part by targeting c Myc; The impact of overexpression of miR-145 on putative target c-Myc was subsequently confirmed via Western blot; Overexpression of miR-145 significantly decreased p < 0.05 the protein level of c-Myc which has previously been identified as a direct target of miR-145; Our results demonstrate that overexpression of miR-145 inhibits tumor growth in part by targeting c-Myc;In colon cancer cells c-Myc is a confirmed direct target for miR-145; The aim of this work was to investigate the effect of miR-145 and c-Myc on proliferation of NSCLC cells using the NSCLC cell lines A549 and H23 as models; We further showed that c-Myc was a direct target for miR-145; Taken together our study results demonstrate that miR-145 inhibits proliferation of NSCLC cells through c-Myc;miR-145 delivery reduced tumor proliferation and increased apoptosis with concomitant repression of c-Myc and ERK5 as novel regulatory target of miR-145;We found a reverse-correlation between the expression of miR-145 and its target genes such as fascin-1 c-myc SMAD2/3 and IGF-1R in breast cancer cell lines and breast cancer patient tissues;Consequently the increased miR-145 induced G1 cell cycle arrest reduced tumor proliferation and increased apoptosis inhibited HCT-116 cell migration and suppressed c-MYC expressions a regulatory target of miR-145 ;;;;;;;cell migration ovarian cancer;melanoma;colon cancer;esophageal cancer;lung squamous cell cancer;colon cancer;breast cancer;colon cancer hsa-miR-24-3p MYC 0.133257261462871 0.212960921400853 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.297311537056991 1.14667789168757e-11 NA NA NA hsa-miR-26a-5p MYC 0.033823776747294 0.726610414342369 0.0342990533418108 0.742963156666191 miRNAWalker2_validate -0.349840372726607 4.11115213986892e-11 21901171 Our results identify new molecular targets of c-Myc in AML and highlight miR-26a attractiveness as a therapeutic target in leukemia acute myeloid leukemia hsa-miR-335-5p MYC 0.0938511632756978 0.336889056387694 0.0342990533418108 0.742963156666191 miRNAWalker2_validate -0.221233805698315 6.63171764745164e-07 NA NA NA hsa-miR-34a-5p MYC 0.143472919835524 0.211283228567057 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.469833736893329 6.08752675410229e-40 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-34c-5p MYC 0.181931113688093 0.257266965617363 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase;miRanda -0.212118906251778 1.73484497587865e-16 NA NA NA hsa-miR-377-5p MYC -0.254102489855821 0.081507589808783 0.0342990533418108 0.742963156666191 miRNATAP -0.197215758202484 1.41992056070433e-11 NA NA NA hsa-miR-378a-3p MYC 0.251965146196782 0.0137483824840962 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.135286330402019 0.00204077080845563 NA NA NA hsa-miR-590-3p MYC 0.312951515438396 0.000480455423843996 0.0342990533418108 0.742963156666191 miRanda -0.223628987104378 2.58191493375387e-06 24200043 We identified important regulators MYC NFKB1 miR-590 and miR-570 and significant miRNA-TF synergistic regulatory motifs by random simulations lung squamous cell cancer hsa-miR-744-5p MYC -0.31868579180387 0.000969037378618306 0.0342990533418108 0.742963156666191 miRNAWalker2_validate -0.208939879123018 7.28554627025748e-06 24991193 Decrease expression of microRNA 744 promotes cell proliferation by targeting c Myc in human hepatocellular carcinoma; Quantitative reverse-transcription polymerase chain reaction qRT-PCR was conducted to detect the expression of miR-744 and Immunohistochemistry was performed to detect expression of c-Myc in HCC specimens and adjacent normal tissues; Luciferase reporter assays was performed to confirm whether miR-744 regulated the expression of c-Myc; Luciferase assay and Western blot analysis revealed that c-Myc is a direct target of miR-744; Down-regulation of miR-744 and up-regulation of c-Myc were detected in HCC specimens compared with adjacent normal tissues; Moreover restoration of miR-744 rescues c-Myc induced HCC proliferation; Our data suggest that miR-744 exerts its tumor suppressor function by targeting c-Myc leading to the inhibition of HCC cell growth liver cancer hsa-miR-98-5p MYC -0.0806971683871618 0.251777941211683 0.0342990533418108 0.742963156666191 miRNAWalker2_validate;miRTarBase -0.482234879670646 1.25183084383233e-12 NA NA NA hsa-let-7e-5p NF1 0.0471189209570344 0.657255455444655 -0.208322949466337 0.0011458902274678 miRNAWalker2_validate -0.112240974253758 5.20664404957301e-06 NA NA NA hsa-miR-103a-3p NF1 -0.147443193527362 0.128400914654149 -0.208322949466337 0.0011458902274678 MirTarget -0.279787322386383 9.63924737420609e-14 NA NA NA hsa-miR-125a-3p NF1 0.183834985432376 0.106230647107917 -0.208322949466337 0.0011458902274678 MirTarget;PITA;miRanda;miRNATAP -0.108763335831917 3.06806718987825e-08 NA NA NA hsa-miR-141-3p NF1 0.41120561991992 0.000393344390969055 -0.208322949466337 0.0011458902274678 mirMAP -0.154842879400521 4.15540253992273e-16 NA NA NA hsa-miR-146b-5p NF1 0.441078059667297 0.000237619929889385 -0.208322949466337 0.0011458902274678 miRanda -0.206218820065857 4.97898551937265e-29 NA NA NA hsa-miR-15a-5p NF1 0.142658985373611 0.0536219185009004 -0.208322949466337 0.0011458902274678 MirTarget -0.212647271024111 3.89531848172501e-09 NA NA NA hsa-miR-15b-5p NF1 0.592863156692837 1.41971517354055e-10 -0.208322949466337 0.0011458902274678 MirTarget -0.223371519381971 7.38949095688687e-20 NA NA NA hsa-miR-193a-3p NF1 0.395602305834739 0.00182611787714301 -0.208322949466337 0.0011458902274678 miRanda -0.114270075994005 9.864531962287e-11 NA NA NA hsa-miR-199a-5p NF1 0.174889610847968 0.0900027418912454 -0.208322949466337 0.0011458902274678 miRanda -0.107628627600729 7.72476898005927e-07 NA NA NA hsa-miR-199b-5p NF1 0.436298593972862 0.00200225454383871 -0.208322949466337 0.0011458902274678 miRanda -0.12455880164847 3.78533947782799e-16 NA NA NA hsa-miR-27a-3p NF1 0.303760032895792 0.00457375391189806 -0.208322949466337 0.0011458902274678 MirTarget -0.119789628615369 8.04107318966667e-08 NA NA NA hsa-miR-28-5p NF1 0.104003572105781 0.153594705579534 -0.208322949466337 0.0011458902274678 miRanda -0.173631313285854 1.14205896241135e-07 NA NA NA hsa-miR-29b-1-5p NF1 0.191335428755774 0.00846436454790702 -0.208322949466337 0.0011458902274678 mirMAP -0.123133163680988 5.6831021352664e-05 NA NA NA hsa-miR-30a-5p NF1 -0.062942936611238 0.513851954700252 -0.208322949466337 0.0011458902274678 MirTarget;mirMAP;miRNATAP -0.22028884976692 5.87049235871482e-09 NA NA NA hsa-miR-30b-5p NF1 -0.0858101016322106 0.263243418521854 -0.208322949466337 0.0011458902274678 MirTarget;mirMAP -0.202204782886355 5.71701288641473e-09 NA NA NA hsa-miR-30c-5p NF1 -0.0469114469943097 0.565934557464627 -0.208322949466337 0.0011458902274678 MirTarget;mirMAP;miRNATAP -0.285158877990468 8.93342264409763e-17 NA NA NA hsa-miR-30e-5p NF1 0.0764521828640934 0.41904991629622 -0.208322949466337 0.0011458902274678 MirTarget;mirMAP -0.106353213765329 0.00138760965841904 NA NA NA hsa-miR-361-5p NF1 0.0107519600643302 0.882230614095565 -0.208322949466337 0.0011458902274678 miRanda -0.21203313018317 2.09196687287572e-08 NA NA NA hsa-miR-362-3p NF1 0.032375035235532 0.736465332563774 -0.208322949466337 0.0011458902274678 miRanda -0.101752829398611 1.106583550246e-05 NA NA NA hsa-miR-362-5p NF1 -0.0730185557229279 0.425572997292224 -0.208322949466337 0.0011458902274678 mirMAP -0.109449743347363 9.32353758054643e-06 NA NA NA hsa-miR-452-5p NF1 0.599327068454211 1.02031931068531e-05 -0.208322949466337 0.0011458902274678 MirTarget -0.110222398533347 5.2292740136393e-12 NA NA NA hsa-miR-455-5p NF1 0.332224239762 0.0106491358056238 -0.208322949466337 0.0011458902274678 miRanda -0.118083682156973 2.34344893963398e-12 NA NA NA hsa-miR-590-3p NF1 0.312951515438396 0.000480455423843996 -0.208322949466337 0.0011458902274678 MirTarget;PITA;miRanda;miRNATAP -0.16724229498015 7.78156222698355e-12 NA NA NA hsa-miR-590-5p NF1 0.16946027035949 0.0386004382081678 -0.208322949466337 0.0011458902274678 miRanda -0.115896038002145 2.43570759105084e-05 NA NA NA hsa-miR-133a-3p NFATC2 -0.335058908302964 0.0180402783121034 0.373288538309896 0.0141934989113001 MirTarget -0.126883299764603 0.00682609791314944 NA NA NA hsa-miR-137 NFATC2 -0.924849266740909 1.546832202049e-06 0.373288538309896 0.0141934989113001 MirTarget -0.159446756645839 2.79388179466433e-06 NA NA NA hsa-miR-19a-3p NFATC2 0.0466707843731911 0.576818938277755 0.373288538309896 0.0141934989113001 mirMAP -0.236809111690551 0.00474447094856751 NA NA NA hsa-miR-19b-3p NFATC2 -0.0138427450847924 0.856506310673067 0.373288538309896 0.0141934989113001 mirMAP -0.335169271204236 0.000783248779037379 NA NA NA hsa-miR-767-3p NFATC2 -0.429854368420513 0.000821445291167688 0.373288538309896 0.0141934989113001 mirMAP -0.151337879902996 0.0044563221543633 NA NA NA hsa-miR-9-5p NFATC2 -0.125377971246422 0.269896477802284 0.373288538309896 0.0141934989113001 MirTarget -1.15506700903417 6.16080043646465e-16 NA NA NA hsa-miR-105-5p NFATC4 -0.567459149851677 8.20858944634795e-06 -0.081124592384517 0.381792074940761 mirMAP -0.233035161096435 4.65846890944727e-14 NA NA NA hsa-miR-181a-2-3p NFATC4 -0.0630409614874416 0.473088318215936 -0.081124592384517 0.381792074940761 mirMAP -0.280233830341353 9.31458848849117e-06 NA NA NA hsa-miR-3607-3p NFATC4 -0.0118040987013632 0.907228689257085 -0.081124592384517 0.381792074940761 miRNATAP -0.166177847132163 2.36930087506819e-05 NA NA NA hsa-miR-1179 NFKB1 -0.117056451908751 0.310989525634765 0.146182859193676 0.0048570839713069 miRNATAP -0.140273206429428 5.35154124955416e-17 NA NA NA hsa-miR-508-3p NFKB1 -0.292045725850845 0.0158994578296519 0.146182859193676 0.0048570839713069 MirTarget;PITA;miRNATAP -0.101247627472892 1.16240035097528e-10 NA NA NA hsa-miR-9-5p NFKB1 -0.125377971246422 0.269896477802284 0.146182859193676 0.0048570839713069 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.336428914988368 4.98439106747222e-16 NA NA NA hsa-miR-193b-3p NFKB2 0.0766333116224072 0.324723824453143 0.181248412618149 0.00703832473154704 miRNAWalker2_validate -0.122294468838196 0.00117322160972805 NA NA NA hsa-miR-491-5p NFKB2 -0.749881113074983 8.22859263179194e-09 0.181248412618149 0.00703832473154704 miRanda -0.173306006407822 1.58981128588846e-17 NA NA NA hsa-let-7c-5p NGF -0.04295851886768 0.676052842748691 -0.416457950464278 0.0030667540551424 MirTarget -0.360257350329555 1.22298479321338e-05 NA NA NA hsa-let-7e-5p NGF 0.0471189209570344 0.657255455444655 -0.416457950464278 0.0030667540551424 MirTarget -0.207654601525943 0.00237596292059546 NA NA NA hsa-let-7i-5p NGF 0.0952853587923244 0.192120688957249 -0.416457950464278 0.0030667540551424 MirTarget -0.412016019685442 0.000120893499183623 NA NA NA hsa-miR-217 NGF 0.540279882451941 0.00312206944061206 -0.416457950464278 0.0030667540551424 miRanda -0.106355636018351 0.00151830983295066 NA NA NA hsa-miR-320a NGF 0.092135599636725 0.243028758989929 -0.416457950464278 0.0030667540551424 miRanda -0.445535637234912 4.53615837617544e-06 NA NA NA hsa-miR-320b NGF 0.283477746304177 0.0005953763020907 -0.416457950464278 0.0030667540551424 miRanda -0.295144471999818 6.92199710987292e-05 NA NA NA hsa-miR-320c NGF 0.343259124189966 0.000248338401291051 -0.416457950464278 0.0030667540551424 miRanda -0.420643347773402 2.54365030935421e-10 NA NA NA hsa-miR-423-5p NGF 0.0965587900813789 0.148039180704338 -0.416457950464278 0.0030667540551424 MirTarget;miRNATAP -0.377352274624578 0.000280283896732406 NA NA NA hsa-miR-195-3p NLK 0.100105455903079 0.133362389112338 -0.134361431213828 0.0181559794912115 mirMAP -0.146201038430761 1.34424900039389e-05 NA NA NA hsa-miR-320c NLK 0.343259124189966 0.000248338401291051 -0.134361431213828 0.0181559794912115 miRanda -0.113293155197013 1.87419575521197e-06 NA NA NA hsa-miR-542-3p NR4A1 0.0835995677900829 0.403838744494071 0.0613075765545483 0.584024522339382 PITA;miRanda -0.147057593375991 0.00410521002686925 NA NA NA hsa-miR-29a-3p NRAS -0.224140851576083 0.0349516103550236 0.166825456686155 0.00198701675555357 miRNATAP -0.113429370178798 7.18564270439906e-07 NA NA NA hsa-miR-29c-3p NRAS -0.372180390387259 0.00202634431973208 0.166825456686155 0.00198701675555357 miRNATAP -0.103186593831709 9.57910873311229e-10 NA NA NA hsa-miR-664a-3p NRAS 0.0413918462467198 0.611334357897022 0.166825456686155 0.00198701675555357 MirTarget -0.11306016643066 1.53334474091839e-06 NA NA NA hsa-miR-137 NTRK1 -0.924849266740909 1.546832202049e-06 0.207348057458216 0.0386791072527031 miRanda -0.117432442139169 1.38166281095279e-07 NA NA NA hsa-miR-1179 NTRK2 -0.117056451908751 0.310989525634765 -0.686181111372964 1.63868289231844e-08 mirMAP -0.117785076587188 0.00455990920871272 NA NA NA hsa-miR-125a-3p NTRK2 0.183834985432376 0.106230647107917 -0.686181111372964 1.63868289231844e-08 miRanda -0.117049049301132 0.00488026725384927 NA NA NA hsa-miR-126-5p NTRK2 0.177332403948664 0.0711675116243123 -0.686181111372964 1.63868289231844e-08 mirMAP -0.210559355701016 2.22333970399353e-05 NA NA NA hsa-miR-130b-3p NTRK2 0.503911467685709 9.46590588950823e-08 -0.686181111372964 1.63868289231844e-08 mirMAP -0.48198693041308 1.47745844823795e-23 NA NA NA hsa-miR-130b-5p NTRK2 0.413070888963592 1.98866876365509e-06 -0.686181111372964 1.63868289231844e-08 mirMAP -0.348405926099145 1.78702109563048e-10 NA NA NA hsa-miR-140-3p NTRK2 -0.123864258867705 0.14796686619449 -0.686181111372964 1.63868289231844e-08 PITA -0.197847075214346 0.00628433840688937 NA NA NA hsa-miR-140-5p NTRK2 0.065063507103468 0.380452509211773 -0.686181111372964 1.63868289231844e-08 miRanda -0.259527342352345 0.000145290714682029 NA NA NA hsa-miR-143-3p NTRK2 0.289829963197683 0.0420892105534401 -0.686181111372964 1.63868289231844e-08 mirMAP -0.185965853420384 4.47219518844906e-07 NA NA NA hsa-miR-145-3p NTRK2 0.110543172922298 0.294150620210019 -0.686181111372964 1.63868289231844e-08 mirMAP -0.20443079458531 3.43520671853098e-06 NA NA NA hsa-miR-146b-5p NTRK2 0.441078059667297 0.000237619929889385 -0.686181111372964 1.63868289231844e-08 PITA;miRanda -0.285774957078472 8.72386440944543e-13 NA NA NA hsa-miR-155-5p NTRK2 0.969837380981085 5.86551495710056e-15 -0.686181111372964 1.63868289231844e-08 mirMAP -0.311414873073455 1.77395270740727e-18 NA NA NA hsa-miR-15b-3p NTRK2 0.690804403863844 8.48784755123775e-09 -0.686181111372964 1.63868289231844e-08 mirMAP -0.275120345518809 2.07845831566898e-13 NA NA NA hsa-miR-17-3p NTRK2 0.0217768908350733 0.801140991374649 -0.686181111372964 1.63868289231844e-08 miRNATAP -0.267488399217568 1.51674456927697e-05 NA NA NA hsa-miR-181b-5p NTRK2 0.0260899284211646 0.768941836912518 -0.686181111372964 1.63868289231844e-08 mirMAP -0.275460361374369 2.69131478075794e-05 NA NA NA hsa-miR-200c-3p NTRK2 0.413752622631695 8.6936333715621e-06 -0.686181111372964 1.63868289231844e-08 miRNAWalker2_validate;miRTarBase -0.189312281448708 0.000151698853560443 23209748;23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis ;drug resistance breast cancer;ovarian cancer hsa-miR-21-5p NTRK2 1.0504925175311 2.58081295984106e-11 -0.686181111372964 1.63868289231844e-08 mirMAP -0.236108791238634 4.9068404718365e-13 NA NA NA hsa-miR-27b-5p NTRK2 0.224282840351546 0.00630787296051719 -0.686181111372964 1.63868289231844e-08 mirMAP -0.182354407883954 0.00140069809613523 NA NA NA hsa-miR-320a NTRK2 0.092135599636725 0.243028758989929 -0.686181111372964 1.63868289231844e-08 mirMAP -0.320169674390035 1.45235884491897e-05 NA NA NA hsa-miR-320b NTRK2 0.283477746304177 0.0005953763020907 -0.686181111372964 1.63868289231844e-08 mirMAP -0.297676719953335 1.05142976932486e-07 NA NA NA hsa-miR-335-3p NTRK2 0.34540584335595 0.00043848660222294 -0.686181111372964 1.63868289231844e-08 mirMAP -0.301664968205129 5.38168841975694e-10 NA NA NA hsa-miR-335-5p NTRK2 0.0938511632756978 0.336889056387694 -0.686181111372964 1.63868289231844e-08 miRNAWalker2_validate -0.142160869298563 0.00359656740597952 NA NA NA hsa-miR-339-5p NTRK2 0.273253751377152 0.0185300170790638 -0.686181111372964 1.63868289231844e-08 miRanda -0.145781932800226 0.000287943821956961 NA NA NA hsa-miR-361-5p NTRK2 0.0107519600643302 0.882230614095565 -0.686181111372964 1.63868289231844e-08 miRanda;mirMAP -0.29237397328415 0.000253896813933908 NA NA NA hsa-miR-376c-3p NTRK2 -0.0513360810290662 0.710610589791979 -0.686181111372964 1.63868289231844e-08 mirMAP -0.140327427013934 3.33516406165561e-05 NA NA NA hsa-miR-409-3p NTRK2 0.00456692516634361 0.974143243758506 -0.686181111372964 1.63868289231844e-08 mirMAP -0.110267529518122 0.000884459244523279 NA NA NA hsa-miR-452-5p NTRK2 0.599327068454211 1.02031931068531e-05 -0.686181111372964 1.63868289231844e-08 mirMAP -0.169844766254734 5.09543021020336e-07 NA NA NA hsa-miR-454-3p NTRK2 0.177318549827649 0.0120865170334418 -0.686181111372964 1.63868289231844e-08 mirMAP -0.20934244817509 0.00245368136356355 NA NA NA hsa-miR-501-5p NTRK2 0.0878951859817452 0.309663377222443 -0.686181111372964 1.63868289231844e-08 mirMAP -0.145000560300687 0.00765735539714478 NA NA NA hsa-miR-590-3p NTRK2 0.312951515438396 0.000480455423843996 -0.686181111372964 1.63868289231844e-08 PITA;miRanda;mirMAP -0.221156268667124 2.02480061352176e-05 NA NA NA hsa-miR-590-5p NTRK2 0.16946027035949 0.0386004382081678 -0.686181111372964 1.63868289231844e-08 miRanda;mirMAP -0.155176251936937 0.00726049632647802 NA NA NA hsa-miR-320a PAK1 0.092135599636725 0.243028758989929 -0.0861639821170765 0.472264496235081 miRNAWalker2_validate;PITA;miRanda -0.440070048455266 5.8461135519197e-08 NA NA NA hsa-miR-320b PAK1 0.283477746304177 0.0005953763020907 -0.0861639821170765 0.472264496235081 PITA;miRanda -0.18860603631333 0.00250151683223796 NA NA NA hsa-miR-320c PAK1 0.343259124189966 0.000248338401291051 -0.0861639821170765 0.472264496235081 PITA;miRanda -0.240520876595702 1.96303772722076e-05 NA NA NA hsa-miR-423-5p PAK1 0.0965587900813789 0.148039180704338 -0.0861639821170765 0.472264496235081 miRNAWalker2_validate -0.312154649877171 0.000338522441056953 NA NA NA hsa-miR-342-3p PAK2 -0.125683829770877 0.105810751640137 0.0709706465766624 0.173159070772672 MirTarget;PITA;miRanda -0.149333228316984 2.76257081493856e-12 NA NA NA hsa-miR-361-5p PAK2 0.0107519600643302 0.882230614095565 0.0709706465766624 0.173159070772672 mirMAP -0.160327396785592 2.93784847431797e-10 NA NA NA hsa-miR-425-5p PAK2 -0.0412837711174561 0.682284485592858 0.0709706465766624 0.173159070772672 MirTarget -0.115829234353775 8.12642545192366e-14 NA NA NA hsa-miR-500a-3p PAK2 0.0479457078972052 0.49420307623914 0.0709706465766624 0.173159070772672 miRNAWalker2_validate -0.124847364931628 6.67497779683746e-07 NA NA NA hsa-miR-7-1-3p PAK2 -0.0894475316162393 0.37322359785108 0.0709706465766624 0.173159070772672 MirTarget -0.141197841123289 2.45832364038912e-22 NA NA NA hsa-miR-769-3p PAK2 -0.287263649023213 0.018145224330845 0.0709706465766624 0.173159070772672 PITA;miRNATAP -0.118358970821312 1.94543113981314e-23 NA NA NA hsa-miR-3065-5p PDGFA -0.262608140481507 0.0414570974148034 0.490091510735296 1.12439737196867e-06 mirMAP -0.172968495924815 2.92745603338613e-07 NA NA NA hsa-miR-767-5p PDGFB -0.551653504513145 2.61109058244854e-05 0.264702010292632 0.000199580243175127 PITA;miRNATAP -0.139160724595735 2.76800071159541e-10 NA NA NA hsa-let-7a-2-3p PDGFRA 0.295235553592458 0.00290654476250609 -0.214227835759073 0.123422750860196 MirTarget -0.296334233533416 4.11922197722786e-07 NA NA NA hsa-let-7f-1-3p PDGFRA 0.110713086694053 0.21484524300518 -0.214227835759073 0.123422750860196 mirMAP -0.239111230215239 0.000205273554105078 NA NA NA hsa-miR-106a-5p PDGFRA 0.110074064773897 0.13045815990621 -0.214227835759073 0.123422750860196 MirTarget;miRNATAP -0.291101709809366 0.000522324338760065 NA NA NA hsa-miR-125a-3p PDGFRA 0.183834985432376 0.106230647107917 -0.214227835759073 0.123422750860196 miRanda -0.218704614786785 1.83272444389053e-05 NA NA NA hsa-miR-125a-5p PDGFRA -0.0833349424517387 0.325440200253607 -0.214227835759073 0.123422750860196 miRanda -0.584043237308749 1.35379706476998e-12 NA NA NA hsa-miR-132-3p PDGFRA -0.178379362833856 0.13335200877129 -0.214227835759073 0.123422750860196 miRNATAP -0.187831850273597 0.000250319391344747 NA NA NA hsa-miR-141-3p PDGFRA 0.41120561991992 0.000393344390969055 -0.214227835759073 0.123422750860196 MirTarget -0.212944157891481 2.31787320191516e-05 NA NA NA hsa-miR-142-5p PDGFRA 0.434884875454107 0.000575570345702788 -0.214227835759073 0.123422750860196 PITA;mirMAP;miRNATAP -0.255106354672294 1.29328581244106e-08 NA NA NA hsa-miR-143-3p PDGFRA 0.289829963197683 0.0420892105534401 -0.214227835759073 0.123422750860196 miRNATAP -0.188499057787187 3.61701378371554e-05 NA NA NA hsa-miR-146b-5p PDGFRA 0.441078059667297 0.000237619929889385 -0.214227835759073 0.123422750860196 miRanda -0.439250339471549 1.63797229980143e-19 NA NA NA hsa-miR-149-5p PDGFRA -0.0535821592029952 0.657713892012548 -0.214227835759073 0.123422750860196 MirTarget;miRNATAP -0.251126677334923 2.0149615804524e-07 NA NA NA hsa-miR-16-1-3p PDGFRA 0.346674816118499 1.86447850167636e-05 -0.214227835759073 0.123422750860196 MirTarget -0.225776587776573 0.0016066501712407 NA NA NA hsa-miR-184 PDGFRA -0.842534984406592 6.08844932016991e-08 -0.214227835759073 0.123422750860196 miRanda -0.153784899830709 2.69381514856598e-05 NA NA NA hsa-miR-186-5p PDGFRA 0.0606381894130505 0.514217717592464 -0.214227835759073 0.123422750860196 MirTarget -0.297882320589264 1.23111767407722e-05 NA NA NA hsa-miR-193a-3p PDGFRA 0.395602305834739 0.00182611787714301 -0.214227835759073 0.123422750860196 miRanda -0.273002234423519 2.46644840364766e-09 NA NA NA hsa-miR-199a-3p PDGFRA 0.41226331871076 0.000497136154474528 -0.214227835759073 0.123422750860196 MirTarget;PITA;miRNATAP -0.270733214461539 2.93296438648829e-08 NA NA NA hsa-miR-199a-5p PDGFRA 0.174889610847968 0.0900027418912454 -0.214227835759073 0.123422750860196 miRanda -0.26790376826415 1.965281983763e-06 NA NA NA hsa-miR-199b-3p PDGFRA 0.411848361704393 0.000517815011892379 -0.214227835759073 0.123422750860196 MirTarget;PITA;miRNATAP -0.269173280120204 3.28792716796774e-08 NA NA NA hsa-miR-199b-5p PDGFRA 0.436298593972862 0.00200225454383871 -0.214227835759073 0.123422750860196 miRanda -0.181040865656848 7.35837504952751e-06 NA NA NA hsa-miR-20b-5p PDGFRA 0.144541062989476 0.0992042333556543 -0.214227835759073 0.123422750860196 MirTarget;miRNATAP -0.280949056106333 7.10780599325753e-05 NA NA NA hsa-miR-212-3p PDGFRA -0.014112941209349 0.918360379512974 -0.214227835759073 0.123422750860196 miRNATAP -0.165210568743679 7.56823088897284e-05 NA NA NA hsa-miR-24-3p PDGFRA 0.133257261462871 0.212960921400853 -0.214227835759073 0.123422750860196 MirTarget;miRNATAP -0.258693453202796 1.426608452579e-05 NA NA NA hsa-miR-26a-5p PDGFRA 0.033823776747294 0.726610414342369 -0.214227835759073 0.123422750860196 MirTarget;mirMAP;miRNATAP -0.337817549965926 2.64891798560313e-06 NA NA NA hsa-miR-26b-5p PDGFRA -0.0984536538762768 0.231803769574623 -0.214227835759073 0.123422750860196 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.330492068006605 7.86276476912204e-05 NA NA NA hsa-miR-27a-3p PDGFRA 0.303760032895792 0.00457375391189806 -0.214227835759073 0.123422750860196 MirTarget;miRNATAP -0.332717954435526 7.42608425988857e-09 NA NA NA hsa-miR-27b-3p PDGFRA -0.0599187745243146 0.58208143475992 -0.214227835759073 0.123422750860196 MirTarget;miRNATAP -0.312048975764859 7.61491715727402e-08 NA NA NA hsa-miR-28-5p PDGFRA 0.104003572105781 0.153594705579534 -0.214227835759073 0.123422750860196 miRanda -0.408002281031611 1.50274553396473e-06 NA NA NA hsa-miR-29a-3p PDGFRA -0.224140851576083 0.0349516103550236 -0.214227835759073 0.123422750860196 MirTarget -0.433860748502012 5.47540666642455e-10 NA NA NA hsa-miR-29b-1-5p PDGFRA 0.191335428755774 0.00846436454790702 -0.214227835759073 0.123422750860196 mirMAP -0.444219655383209 1.48743564059219e-08 NA NA NA hsa-miR-29b-2-5p PDGFRA -0.26834261955727 0.00453760540520233 -0.214227835759073 0.123422750860196 mirMAP -0.403170180391648 4.54797630182334e-11 NA NA NA hsa-miR-29b-3p PDGFRA -0.178522712044497 0.0856106432165465 -0.214227835759073 0.123422750860196 MirTarget -0.479354783825126 2.78031130409556e-15 NA NA NA hsa-miR-29c-3p PDGFRA -0.372180390387259 0.00202634431973208 -0.214227835759073 0.123422750860196 MirTarget -0.325784473603734 3.2768258385201e-10 NA NA NA hsa-miR-320c PDGFRA 0.343259124189966 0.000248338401291051 -0.214227835759073 0.123422750860196 miRanda -0.25132609270931 6.63976805483441e-05 NA NA NA hsa-miR-330-5p PDGFRA -0.262932095995605 0.0465226565966658 -0.214227835759073 0.123422750860196 miRanda -0.122999029913756 0.00489006932093651 NA NA NA hsa-miR-335-3p PDGFRA 0.34540584335595 0.00043848660222294 -0.214227835759073 0.123422750860196 mirMAP -0.296573735389458 8.96271541553145e-07 NA NA NA hsa-miR-339-5p PDGFRA 0.273253751377152 0.0185300170790638 -0.214227835759073 0.123422750860196 miRanda -0.331337860958994 1.16346191528288e-11 NA NA NA hsa-miR-34a-5p PDGFRA 0.143472919835524 0.211283228567057 -0.214227835759073 0.123422750860196 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.507657602010947 6.25800263585505e-25 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-34c-5p PDGFRA 0.181931113688093 0.257266965617363 -0.214227835759073 0.123422750860196 MirTarget;PITA;miRanda;miRNATAP -0.238616457279072 8.42235088990927e-12 NA NA NA hsa-miR-362-3p PDGFRA 0.032375035235532 0.736465332563774 -0.214227835759073 0.123422750860196 miRanda -0.25592920204664 1.90006109239814e-05 NA NA NA hsa-miR-455-5p PDGFRA 0.332224239762 0.0106491358056238 -0.214227835759073 0.123422750860196 MirTarget;PITA;miRanda -0.206982425909943 2.64647669398927e-06 NA NA NA hsa-miR-488-3p PDGFRA -0.257955761012568 0.00280795162806256 -0.214227835759073 0.123422750860196 mirMAP -0.245006697838914 0.000325177624269067 NA NA NA hsa-miR-576-5p PDGFRA 0.106482276040047 0.194379152564166 -0.214227835759073 0.123422750860196 mirMAP -0.275734374551186 0.000105383234164016 NA NA NA hsa-miR-590-3p PDGFRA 0.312951515438396 0.000480455423843996 -0.214227835759073 0.123422750860196 miRanda;mirMAP -0.360558237867372 1.42959874478908e-08 NA NA NA hsa-miR-590-5p PDGFRA 0.16946027035949 0.0386004382081678 -0.214227835759073 0.123422750860196 miRanda -0.339783423553957 1.57951301556451e-06 NA NA NA hsa-miR-664a-3p PDGFRA 0.0413918462467198 0.611334357897022 -0.214227835759073 0.123422750860196 mirMAP -0.68336198484181 1.47148431801351e-22 NA NA NA hsa-miR-7-1-3p PDGFRA -0.0894475316162393 0.37322359785108 -0.214227835759073 0.123422750860196 mirMAP -0.241177783617488 2.86345919927891e-05 NA NA NA hsa-miR-9-5p PDGFRB -0.125377971246422 0.269896477802284 0.193259964403652 0.00272288258408316 MirTarget;miRNATAP -0.367539214293885 4.33000477969503e-12 NA NA NA hsa-miR-106b-5p PLA2G12A 0.167096183547615 0.0497544396383451 -0.181962072480256 2.70460580179857e-05 mirMAP -0.123794031417231 8.40767531912829e-12 NA NA NA hsa-miR-93-5p PLA2G12A 0.139766237971122 0.101057320076629 -0.181962072480256 2.70460580179857e-05 mirMAP -0.134716211565272 5.93753764091159e-08 NA NA NA hsa-miR-491-5p PLA2G2A -0.749881113074983 8.22859263179194e-09 1.29188933567535 4.98156559625774e-07 miRanda -0.225010501106316 0.00842290234172622 NA NA NA hsa-miR-139-5p PLA2G4A -0.647754756897633 2.15378307237163e-06 0.459553101816434 3.96979969592525e-06 miRanda -0.196719913317323 1.19655643220759e-09 NA NA NA hsa-miR-2355-3p PLA2G6 0.186207523505296 0.0525918026993012 -0.329810877626427 6.39462398247452e-09 MirTarget -0.136794319081761 8.98869883320535e-10 NA NA NA hsa-miR-30a-3p PLA2G6 0.0655410309550977 0.509541256241954 -0.329810877626427 6.39462398247452e-09 miRNATAP -0.179375158849384 2.09226484033404e-10 NA NA NA hsa-miR-30d-3p PLA2G6 0.0854049347792898 0.20691254801121 -0.329810877626427 6.39462398247452e-09 miRNATAP -0.157387082946513 1.14186003565846e-06 NA NA NA hsa-miR-324-5p PLA2G6 0.0183370482495953 0.842996782677271 -0.329810877626427 6.39462398247452e-09 miRanda -0.112311121172656 2.84645215254445e-06 NA NA NA hsa-miR-15a-5p PPM1A 0.142658985373611 0.0536219185009004 -0.249516338200001 8.66968062861746e-07 MirTarget;miRNATAP -0.11842723178386 1.83942052994083e-05 NA NA NA hsa-miR-15b-5p PPM1A 0.592863156692837 1.41971517354055e-10 -0.249516338200001 8.66968062861746e-07 MirTarget;miRNATAP -0.160049859618251 1.09131723344293e-17 NA NA NA hsa-miR-320a PPM1A 0.092135599636725 0.243028758989929 -0.249516338200001 8.66968062861746e-07 miRanda -0.122360058749922 4.81280561524277e-06 NA NA NA hsa-miR-3613-5p PPM1A 0.290347525750076 0.000408393430033494 -0.249516338200001 8.66968062861746e-07 miRNATAP -0.115068991349528 2.38319718044596e-08 NA NA NA hsa-miR-500a-5p PPM1A 0.0634452729978863 0.396072382601677 -0.249516338200001 8.66968062861746e-07 mirMAP -0.10684559882452 2.47053411840873e-06 NA NA NA hsa-miR-93-5p PPM1A 0.139766237971122 0.101057320076629 -0.249516338200001 8.66968062861746e-07 mirMAP -0.152177343363723 6.00261918498629e-07 NA NA NA hsa-miR-200c-3p PPM1B 0.413752622631695 8.6936333715621e-06 -0.162829390263949 0.00113211943962559 miRNATAP -0.110811277993359 7.52316135391085e-13 NA NA NA hsa-miR-106b-5p PPP3CA 0.167096183547615 0.0497544396383451 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.156975600850481 8.08375589469546e-06 NA NA NA hsa-miR-17-5p PPP3CA 0.0975751369167082 0.20621110214601 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.156864057675735 0.000234156174021412 NA NA NA hsa-miR-20a-5p PPP3CA -0.0115865752288853 0.887069448776018 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.11299242225162 0.0039148602825986 NA NA NA hsa-miR-21-5p PPP3CA 1.0504925175311 2.58081295984106e-11 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.130424810796755 2.20070954535807e-12 NA NA NA hsa-miR-320a PPP3CA 0.092135599636725 0.243028758989929 -0.373235846566351 7.56900657293056e-08 miRanda -0.211827782030443 4.01920568101511e-07 NA NA NA hsa-miR-320b PPP3CA 0.283477746304177 0.0005953763020907 -0.373235846566351 7.56900657293056e-08 miRanda -0.144192030306541 6.21193412642773e-06 NA NA NA hsa-miR-320c PPP3CA 0.343259124189966 0.000248338401291051 -0.373235846566351 7.56900657293056e-08 miRanda -0.159502579873982 3.05354814536541e-08 NA NA NA hsa-miR-450b-5p PPP3CA 0.270544879013992 0.00801537838499562 -0.373235846566351 7.56900657293056e-08 PITA;mirMAP;miRNATAP -0.158857807775905 1.0971728867913e-09 NA NA NA hsa-miR-93-3p PPP3CA 0.0778767956494004 0.272224943247293 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.103322549875116 0.00846397616128606 NA NA NA hsa-miR-93-5p PPP3CA 0.139766237971122 0.101057320076629 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.294073353489622 5.63338473261847e-10 NA NA NA hsa-miR-15a-5p PPP3CB 0.142658985373611 0.0536219185009004 -0.433160664971454 7.64786199353402e-10 miRNATAP -0.154879727290926 0.000565344774724231 NA NA NA hsa-miR-15b-5p PPP3CB 0.592863156692837 1.41971517354055e-10 -0.433160664971454 7.64786199353402e-10 miRNATAP -0.237305735014458 6.56456884638479e-15 NA NA NA hsa-miR-30a-5p PPP3CB -0.062942936611238 0.513851954700252 -0.433160664971454 7.64786199353402e-10 miRNATAP -0.216347543291675 3.88335269674995e-06 NA NA NA hsa-miR-320a PPP3CB 0.092135599636725 0.243028758989929 -0.433160664971454 7.64786199353402e-10 miRanda -0.283610796821456 3.73775473194107e-11 NA NA NA hsa-miR-320b PPP3CB 0.283477746304177 0.0005953763020907 -0.433160664971454 7.64786199353402e-10 miRanda -0.214071216687752 5.61901615376464e-11 NA NA NA hsa-miR-320c PPP3CB 0.343259124189966 0.000248338401291051 -0.433160664971454 7.64786199353402e-10 miRanda -0.241503669878515 1.61057546698162e-16 NA NA NA hsa-miR-339-5p PPP3CB 0.273253751377152 0.0185300170790638 -0.433160664971454 7.64786199353402e-10 miRanda -0.14695495240965 2.98975197156432e-10 NA NA NA hsa-miR-424-5p PPP3CB 0.25140374049676 0.00709934939774983 -0.433160664971454 7.64786199353402e-10 miRNATAP -0.174803267163998 9.35958492728842e-09 NA NA NA hsa-miR-450b-5p PPP3CB 0.270544879013992 0.00801537838499562 -0.433160664971454 7.64786199353402e-10 MirTarget;PITA;miRNATAP -0.145409462742278 7.85383237188849e-08 NA NA NA hsa-miR-452-5p PPP3CB 0.599327068454211 1.02031931068531e-05 -0.433160664971454 7.64786199353402e-10 MirTarget;miRNATAP -0.100917826632377 3.76376326737129e-07 NA NA NA hsa-miR-501-5p PPP3CB 0.0878951859817452 0.309663377222443 -0.433160664971454 7.64786199353402e-10 PITA;miRNATAP -0.110974250509852 0.000497821238894801 NA NA NA hsa-miR-590-3p PPP3CB 0.312951515438396 0.000480455423843996 -0.433160664971454 7.64786199353402e-10 miRanda -0.13889306492083 5.08331239857392e-06 NA NA NA hsa-miR-500a-3p PPP3CC 0.0479457078972052 0.49420307623914 -0.0407919825674279 0.323390220477665 MirTarget;miRNATAP -0.107532400267747 7.33877743778064e-06 NA NA NA hsa-miR-27a-3p PPP3R1 0.303760032895792 0.00457375391189806 -0.284481378057962 3.41822765696265e-05 miRNATAP -0.102375961650782 9.77727749562009e-05 NA NA NA hsa-miR-320a PPP3R1 0.092135599636725 0.243028758989929 -0.284481378057962 3.41822765696265e-05 PITA;miRanda -0.228132769092911 2.62987783565586e-08 NA NA NA hsa-miR-320b PPP3R1 0.283477746304177 0.0005953763020907 -0.284481378057962 3.41822765696265e-05 PITA;miRanda -0.139121452927635 9.32245529079262e-06 NA NA NA hsa-miR-320c PPP3R1 0.343259124189966 0.000248338401291051 -0.284481378057962 3.41822765696265e-05 PITA;miRanda -0.155051607654631 4.4227147992575e-08 NA NA NA hsa-miR-93-5p PPP3R1 0.139766237971122 0.101057320076629 -0.284481378057962 3.41822765696265e-05 MirTarget;miRNATAP -0.159907992777141 0.000711555619167879 NA NA NA hsa-miR-195-3p PRKACB 0.100105455903079 0.133362389112338 -0.220744787859509 0.000769904555544923 mirMAP -0.108467815706043 0.00216235374196591 NA NA NA hsa-miR-19b-3p PRKACB -0.0138427450847924 0.856506310673067 -0.220744787859509 0.000769904555544923 miRNAWalker2_validate;MirTarget;miRNATAP -0.139345436156152 4.31724651745926e-05 NA NA NA hsa-miR-93-5p PRKACB 0.139766237971122 0.101057320076629 -0.220744787859509 0.000769904555544923 miRNAWalker2_validate -0.173086797632099 2.75308372550666e-05 NA NA NA hsa-miR-146b-5p PRKCA 0.441078059667297 0.000237619929889385 -0.289954367502515 3.07027667899011e-05 mirMAP -0.14319708794989 9.06517098676715e-13 NA NA NA hsa-miR-186-5p PRKCA 0.0606381894130505 0.514217717592464 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.150359410939945 4.84077626913968e-08 NA NA NA hsa-miR-1976 PRKCA 0.127074435034705 0.277235601775457 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.108813705938178 3.46283535790712e-08 NA NA NA hsa-miR-200c-3p PRKCA 0.413752622631695 8.6936333715621e-06 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.178242109766722 4.41123343449352e-13 NA NA NA hsa-miR-22-5p PRKCA 0.0437233965539527 0.639996108995995 -0.289954367502515 3.07027667899011e-05 mirMAP -0.109722618118012 1.49794234596401e-05 NA NA NA hsa-miR-24-2-5p PRKCA 0.285455874963858 0.00610163594056254 -0.289954367502515 3.07027667899011e-05 miRNAWalker2_validate -0.126181943667759 1.61489847928406e-08 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-27b-5p PRKCA 0.224282840351546 0.00630787296051719 -0.289954367502515 3.07027667899011e-05 mirMAP -0.177695243384062 3.0717917979023e-10 NA NA NA hsa-miR-339-5p PRKCA 0.273253751377152 0.0185300170790638 -0.289954367502515 3.07027667899011e-05 mirMAP -0.144247762214447 3.06350803308541e-13 NA NA NA hsa-miR-374a-3p PRKCA 0.176226170437625 0.0343958848425446 -0.289954367502515 3.07027667899011e-05 mirMAP -0.183155883331884 1.46022453353189e-07 NA NA NA hsa-miR-452-5p PRKCA 0.599327068454211 1.02031931068531e-05 -0.289954367502515 3.07027667899011e-05 mirMAP -0.107144316873697 1.95734554580544e-10 NA NA NA hsa-miR-500a-5p PRKCA 0.0634452729978863 0.396072382601677 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.184254955997398 3.38268451218896e-09 NA NA NA hsa-miR-501-5p PRKCA 0.0878951859817452 0.309663377222443 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.110873198819 4.40374990873549e-05 NA NA NA hsa-miR-505-3p PRKCA 0.115486008167472 0.109833720698312 -0.289954367502515 3.07027667899011e-05 miRNAWalker2_validate -0.183149886354061 7.20630466764891e-08 NA NA NA hsa-miR-505-5p PRKCA 0.0973008785018434 0.183209581426791 -0.289954367502515 3.07027667899011e-05 mirMAP -0.102672793703942 0.00160299774148607 NA NA NA hsa-miR-548b-3p PRKCA 0.340474544210108 0.00224491592019745 -0.289954367502515 3.07027667899011e-05 PITA;miRNATAP -0.107410539931332 3.63814329290144e-07 NA NA NA hsa-miR-550a-3p PRKCA 0.311518294008363 0.0015285640451888 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.135787662750574 7.76840887594873e-09 NA NA NA hsa-miR-590-3p PRKCA 0.312951515438396 0.000480455423843996 -0.289954367502515 3.07027667899011e-05 PITA;miRanda;mirMAP;miRNATAP -0.152536946782924 3.436144371863e-09 NA NA NA hsa-miR-93-3p PRKCA 0.0778767956494004 0.272224943247293 -0.289954367502515 3.07027667899011e-05 mirMAP -0.146551656012825 2.11995627214635e-05 NA NA NA hsa-miR-155-5p PRKCB 0.969837380981085 5.86551495710056e-15 -0.682239380816002 3.52750339218814e-07 mirMAP -0.235836634520576 1.53174038755186e-07 NA NA NA hsa-miR-195-3p PRKCB 0.100105455903079 0.133362389112338 -0.682239380816002 3.52750339218814e-07 mirMAP -0.359971667645682 5.30224329291627e-05 NA NA NA hsa-miR-200c-3p PRKCB 0.413752622631695 8.6936333715621e-06 -0.682239380816002 3.52750339218814e-07 MirTarget;miRNATAP -0.208521490107408 0.000752162039048593 NA NA NA hsa-miR-23a-3p PRKCB 0.334693010651106 0.00144448147063433 -0.682239380816002 3.52750339218814e-07 mirMAP -0.27145045765466 1.33239615330638e-05 NA NA NA hsa-miR-27a-3p PRKCB 0.303760032895792 0.00457375391189806 -0.682239380816002 3.52750339218814e-07 MirTarget;miRNATAP -0.215141700970757 0.000219945845412233 NA NA NA hsa-miR-450b-5p PRKCB 0.270544879013992 0.00801537838499562 -0.682239380816002 3.52750339218814e-07 miRNATAP -0.161638000758075 0.00497309309812017 NA NA NA hsa-miR-590-3p PRKCB 0.312951515438396 0.000480455423843996 -0.682239380816002 3.52750339218814e-07 mirMAP -0.223842383414072 0.000503630468502308 NA NA NA hsa-miR-320a PRKCG 0.092135599636725 0.243028758989929 -1.05900738460984 1.8225118256495e-06 MirTarget;miRanda -0.531753093228863 0.000615460761538157 NA NA NA hsa-miR-320b PRKCG 0.283477746304177 0.0005953763020907 -1.05900738460984 1.8225118256495e-06 MirTarget;miRanda -0.367797376788092 0.00188611730145367 NA NA NA hsa-miR-320c PRKCG 0.343259124189966 0.000248338401291051 -1.05900738460984 1.8225118256495e-06 MirTarget;miRanda -0.485123776133657 5.54850190547458e-06 NA NA NA hsa-miR-532-3p PRKCG 0.150624483952741 0.0599635132177191 -1.05900738460984 1.8225118256495e-06 miRNATAP -0.329482037092211 0.00954229687515554 NA NA NA hsa-miR-103a-2-5p PRKX -0.0677071239234235 0.496202425310213 -0.234656702391627 0.00431000884646852 mirMAP -0.185614107823291 3.00149445409194e-08 NA NA NA hsa-miR-126-5p PRKX 0.177332403948664 0.0711675116243123 -0.234656702391627 0.00431000884646852 MirTarget;miRNATAP -0.187301575968566 1.30428005782524e-07 NA NA NA hsa-miR-139-5p PRKX -0.647754756897633 2.15378307237163e-06 -0.234656702391627 0.00431000884646852 MirTarget -0.111049071581413 1.00400340749505e-05 NA NA NA hsa-miR-140-3p PRKX -0.123864258867705 0.14796686619449 -0.234656702391627 0.00431000884646852 mirMAP -0.188792670005692 0.000271546600802212 NA NA NA hsa-miR-143-5p PRKX 0.460068066898162 0.000603073392139956 -0.234656702391627 0.00431000884646852 miRNATAP -0.143226065795783 5.12157339907867e-09 NA NA NA hsa-miR-145-5p PRKX 0.108948399943015 0.310032352776693 -0.234656702391627 0.00431000884646852 MirTarget;miRNATAP -0.222996299939014 7.11591241346387e-12 NA NA NA hsa-miR-148a-3p PRKX 0.306821592493439 0.0392356958885949 -0.234656702391627 0.00431000884646852 MirTarget -0.107273294595938 5.70709078555767e-06 NA NA NA hsa-miR-148b-3p PRKX 0.0710353380371513 0.322794068460232 -0.234656702391627 0.00431000884646852 MirTarget -0.256323857849908 1.74249911988869e-06 NA NA NA hsa-miR-148b-5p PRKX 0.127111784487801 0.188731110216917 -0.234656702391627 0.00431000884646852 mirMAP -0.119235002449208 0.000703942471696724 NA NA NA hsa-miR-16-1-3p PRKX 0.346674816118499 1.86447850167636e-05 -0.234656702391627 0.00431000884646852 MirTarget -0.185074407382809 8.05451956693482e-06 NA NA NA hsa-miR-16-2-3p PRKX 0.468816222075619 7.04377763166292e-05 -0.234656702391627 0.00431000884646852 MirTarget;mirMAP -0.198629542094723 6.08018799340144e-13 NA NA NA hsa-miR-181a-5p PRKX -0.178215604431845 0.0700010802255601 -0.234656702391627 0.00431000884646852 mirMAP -0.15106825040288 0.00123868308466424 NA NA NA hsa-miR-181b-5p PRKX 0.0260899284211646 0.768941836912518 -0.234656702391627 0.00431000884646852 mirMAP -0.279522155835593 2.18438847332363e-09 NA NA NA hsa-miR-19a-3p PRKX 0.0466707843731911 0.576818938277755 -0.234656702391627 0.00431000884646852 miRNATAP -0.124806422804607 0.00303499773107959 NA NA NA hsa-miR-19b-3p PRKX -0.0138427450847924 0.856506310673067 -0.234656702391627 0.00431000884646852 miRNATAP -0.176601983702423 0.000423189660787107 NA NA NA hsa-miR-218-5p PRKX -0.534287404275829 0.00308322441944796 -0.234656702391627 0.00431000884646852 miRNATAP -0.149237768038395 7.9885738260038e-17 NA NA NA hsa-miR-23b-3p PRKX 0.0476610245860094 0.630277683372344 -0.234656702391627 0.00431000884646852 mirMAP -0.19980057428488 1.12685512772789e-07 NA NA NA hsa-miR-26a-2-3p PRKX 0.26597501648608 0.000796444054340143 -0.234656702391627 0.00431000884646852 mirMAP -0.134802899007735 0.00144817261413182 NA NA NA hsa-miR-27b-3p PRKX -0.0599187745243146 0.58208143475992 -0.234656702391627 0.00431000884646852 MirTarget;miRNATAP -0.131368529715051 0.000112253562391766 NA NA NA hsa-miR-29a-3p PRKX -0.224140851576083 0.0349516103550236 -0.234656702391627 0.00431000884646852 mirMAP -0.123863087459517 0.00269106286247111 NA NA NA hsa-miR-29b-3p PRKX -0.178522712044497 0.0856106432165465 -0.234656702391627 0.00431000884646852 mirMAP -0.173413136803338 1.43367881926089e-06 NA NA NA hsa-miR-29c-3p PRKX -0.372180390387259 0.00202634431973208 -0.234656702391627 0.00431000884646852 mirMAP -0.117968228195243 0.000111258392242527 NA NA NA hsa-miR-323b-3p PRKX -0.254474308066903 0.15651329633719 -0.234656702391627 0.00431000884646852 mirMAP -0.121471311882467 3.96651880271252e-11 NA NA NA hsa-miR-335-3p PRKX 0.34540584335595 0.00043848660222294 -0.234656702391627 0.00431000884646852 mirMAP -0.251127596351802 4.37732142750105e-13 NA NA NA hsa-miR-33a-5p PRKX 0.0197996465877179 0.86830656038963 -0.234656702391627 0.00431000884646852 mirMAP -0.10391806415594 0.000224291426001427 NA NA NA hsa-miR-375 PRKX -0.0268401141324031 0.858358101444697 -0.234656702391627 0.00431000884646852 miRNAWalker2_validate;miRanda -0.115694809758222 1.47169050286958e-07 NA NA NA hsa-miR-409-3p PRKX 0.00456692516634361 0.974143243758506 -0.234656702391627 0.00431000884646852 mirMAP -0.224291050887867 1.11264823229881e-22 NA NA NA hsa-miR-432-5p PRKX -0.214242438141977 0.166186087759946 -0.234656702391627 0.00431000884646852 miRNATAP -0.167538839875961 1.88486920036252e-15 NA NA NA hsa-miR-450b-5p PRKX 0.270544879013992 0.00801537838499562 -0.234656702391627 0.00431000884646852 mirMAP -0.102960665807675 0.00204956194458089 NA NA NA hsa-miR-495-3p PRKX -0.421982588962504 0.00504424038526901 -0.234656702391627 0.00431000884646852 MirTarget -0.178449482518289 2.15988126863328e-16 NA NA NA hsa-miR-539-5p PRKX -0.326485413953598 0.0554453076411246 -0.234656702391627 0.00431000884646852 mirMAP -0.144010574364934 5.81971773063992e-14 NA NA NA hsa-miR-542-3p PRKX 0.0835995677900829 0.403838744494071 -0.234656702391627 0.00431000884646852 mirMAP -0.154230342664725 3.08460179424332e-05 NA NA NA hsa-miR-590-3p PRKX 0.312951515438396 0.000480455423843996 -0.234656702391627 0.00431000884646852 mirMAP -0.149486589624489 6.13061408540306e-05 NA NA NA hsa-miR-625-3p PRKX -0.0638840950852737 0.547354471747105 -0.234656702391627 0.00431000884646852 mirMAP -0.214773811263468 1.78365907489191e-11 NA NA NA hsa-miR-935 PRKX -0.277848050075718 0.02166231531395 -0.234656702391627 0.00431000884646852 mirMAP -0.134302509100497 1.78644955549975e-06 NA NA NA hsa-let-7a-2-3p PTPN5 0.295235553592458 0.00290654476250609 -0.432753252957287 0.0392916814706012 MirTarget -0.368290955393487 8.4764681212423e-05 NA NA NA hsa-miR-296-5p PTPN5 -0.0192165981442809 0.870822664524408 -0.432753252957287 0.0392916814706012 miRNATAP -0.397844205510557 2.68039258330448e-07 NA NA NA hsa-miR-326 PTPN7 -0.631050656251074 8.83643450601471e-05 1.11872757965124 3.01431423912308e-13 miRanda -0.193091217690144 4.50731970734362e-06 NA NA NA hsa-miR-379-5p PTPN7 -0.235161426464296 0.139398466639534 1.11872757965124 3.01431423912308e-13 MirTarget -0.135671614637641 0.0026486783878655 NA NA NA hsa-miR-504-5p PTPN7 -0.510726779625117 6.12122269907368e-05 1.11872757965124 3.01431423912308e-13 MirTarget -0.353040439011721 5.0438071446521e-11 NA NA NA hsa-miR-15b-5p PTPRR 0.592863156692837 1.41971517354055e-10 -0.725586738810648 0.000104377410315893 MirTarget -0.353625729299776 0.000155939052680087 NA NA NA hsa-miR-16-1-3p PTPRR 0.346674816118499 1.86447850167636e-05 -0.725586738810648 0.000104377410315893 MirTarget -0.264644341928049 0.00987296833781585 NA NA NA hsa-miR-20a-3p PTPRR 0.102743778777997 0.19677865359751 -0.725586738810648 0.000104377410315893 MirTarget;miRNATAP -0.38833083998302 0.000211652393904579 NA NA NA hsa-miR-217 PTPRR 0.540279882451941 0.00312206944061206 -0.725586738810648 0.000104377410315893 miRanda -0.202109324961405 6.21189740966789e-06 NA NA NA hsa-miR-28-5p PTPRR 0.104003572105781 0.153594705579534 -0.725586738810648 0.000104377410315893 miRanda -0.513355285183276 2.44639912016351e-05 NA NA NA hsa-miR-320a PTPRR 0.092135599636725 0.243028758989929 -0.725586738810648 0.000104377410315893 miRanda -0.731735702653419 1.6191359861358e-08 NA NA NA hsa-miR-320b PTPRR 0.283477746304177 0.0005953763020907 -0.725586738810648 0.000104377410315893 miRanda -0.469789679200343 2.12661808547779e-06 NA NA NA hsa-miR-320c PTPRR 0.343259124189966 0.000248338401291051 -0.725586738810648 0.000104377410315893 miRanda -0.541969128751294 1.26737509633531e-09 NA NA NA hsa-miR-374b-3p PTPRR 0.00769406264478478 0.897944859266164 -0.725586738810648 0.000104377410315893 MirTarget -0.400979044827011 0.00473924032985264 NA NA NA hsa-miR-424-5p PTPRR 0.25140374049676 0.00709934939774983 -0.725586738810648 0.000104377410315893 MirTarget -0.354606377702411 0.000121138247793536 NA NA NA hsa-miR-450b-5p PTPRR 0.270544879013992 0.00801537838499562 -0.725586738810648 0.000104377410315893 MirTarget;PITA;miRNATAP -0.349199749062951 1.9431895286899e-05 NA NA NA hsa-miR-505-3p PTPRR 0.115486008167472 0.109833720698312 -0.725586738810648 0.000104377410315893 MirTarget -0.543430877765503 6.15296335566067e-06 NA NA NA hsa-miR-590-3p PTPRR 0.312951515438396 0.000480455423843996 -0.725586738810648 0.000104377410315893 miRanda -0.330104641205953 0.000324514814437459 NA NA NA hsa-miR-124-3p RAC2 -0.506026514549291 0.0078056370358648 0.543102090563642 6.32748728882766e-07 mirMAP -0.16328824721264 5.64768337601236e-11 NA NA NA hsa-miR-129-5p RAC2 -0.567133990117126 0.00116152215679936 0.543102090563642 6.32748728882766e-07 miRanda -0.163216019318866 3.88418743152648e-09 NA NA NA hsa-miR-491-5p RAC2 -0.749881113074983 8.22859263179194e-09 0.543102090563642 6.32748728882766e-07 miRanda -0.143477171929978 6.8541464600559e-05 NA NA NA hsa-miR-125a-5p RAC3 -0.0833349424517387 0.325440200253607 -0.0694477011024395 0.398923087359439 PITA -0.255720823416584 1.87026446294698e-07 NA NA NA hsa-miR-30c-2-3p RAC3 -0.18630560418806 0.0313113706136533 -0.0694477011024395 0.398923087359439 miRNAWalker2_validate -0.340394704089941 3.11880878701484e-16 NA NA NA hsa-miR-590-3p RAC3 0.312951515438396 0.000480455423843996 -0.0694477011024395 0.398923087359439 miRanda -0.139701651516001 0.000218392196649336 NA NA NA hsa-miR-671-5p RAC3 0.379677704170736 0.000129391032677459 -0.0694477011024395 0.398923087359439 miRNATAP -0.228245307641295 7.53346315814315e-12 NA NA NA hsa-miR-125a-5p RAF1 -0.0833349424517387 0.325440200253607 -0.00553586733389189 0.905894621254653 miRanda -0.122061217158812 1.14719678269113e-13 NA NA NA hsa-miR-146b-3p RAF1 0.283486177568242 0.0118918188864879 -0.00553586733389189 0.905894621254653 MirTarget;PITA;miRNATAP -0.122160060310276 3.66962239698306e-36 NA NA NA hsa-miR-23b-3p RAF1 0.0476610245860094 0.630277683372344 -0.00553586733389189 0.905894621254653 miRNAWalker2_validate -0.142246538184778 8.25666529544947e-31 NA NA NA hsa-miR-484 RAF1 -0.0190828819137732 0.802298900989652 -0.00553586733389189 0.905894621254653 MirTarget -0.126030948035335 1.89321721164606e-15 NA NA NA hsa-miR-128-3p RAP1B -0.781932174412672 7.1812756321342e-10 0.142944911590152 0.00328482194864398 MirTarget -0.147230046784345 1.53070842148117e-27 25017996 miR 128 and miR 149 enhance the chemosensitivity of temozolomide by Rap1B mediated cytoskeletal remodeling in glioblastoma glioblastoma hsa-miR-139-5p RAP1B -0.647754756897633 2.15378307237163e-06 0.142944911590152 0.00328482194864398 miRanda;miRNATAP -0.121287779626316 5.14664639145908e-24 22642900 Regulation of RAP1B by miR 139 suppresses human colorectal carcinoma cell proliferation; Potential functions of miR-139 were evaluated in colorectal carcinoma cell lines SW480 SW620 LS174 T and HCT116 using miR-139 mimics anti-miR-139 and siRNA RAP1B; Mechanistic studies revealed that miR-139 repressed the activity of a reporter gene fused to the 3'-untranslated region of RAP1B whereas miR-139 silencing up-regulated the expression of the reporter gene; RNAi-mediated knockdown of RAP1B phenocopied the antiproliferative effect of miR-139 whereas the overexpression of RAP1B blocked miR-139-mediated antiproliferative effects in CRC cells; Taken together these results demonstrated that miR-139 decreases proliferation by directly targeting RAP1B defining miR-139 as a new putative tumour suppressor miRNA in CRC colorectal cancer hsa-miR-767-5p RAP1B -0.551653504513145 2.61109058244854e-05 0.142944911590152 0.00328482194864398 miRNATAP -0.11071617688106 5.88393562192962e-19 NA NA NA hsa-miR-9-5p RAP1B -0.125377971246422 0.269896477802284 0.142944911590152 0.00328482194864398 miRNATAP -0.345880158918626 6.03962874526603e-23 NA NA NA hsa-miR-155-5p RAPGEF2 0.969837380981085 5.86551495710056e-15 -0.204588778569422 0.000805685668226184 miRNAWalker2_validate;MirTarget -0.118714365530568 2.30525451558852e-12 NA NA NA hsa-miR-15a-5p RAPGEF2 0.142658985373611 0.0536219185009004 -0.204588778569422 0.000805685668226184 miRNATAP -0.109095361953633 0.00245458813666008 NA NA NA hsa-miR-15b-5p RAPGEF2 0.592863156692837 1.41971517354055e-10 -0.204588778569422 0.000805685668226184 miRNATAP -0.155182135802882 2.95288592871019e-10 NA NA NA hsa-miR-19b-3p RAPGEF2 -0.0138427450847924 0.856506310673067 -0.204588778569422 0.000805685668226184 MirTarget;miRNATAP -0.120371437687235 0.000243406759626959 NA NA NA hsa-miR-200c-3p RAPGEF2 0.413752622631695 8.6936333715621e-06 -0.204588778569422 0.000805685668226184 MirTarget;miRNATAP -0.11946445637953 3.233624726525e-07 NA NA NA hsa-miR-30a-5p RAPGEF2 -0.062942936611238 0.513851954700252 -0.204588778569422 0.000805685668226184 MirTarget;miRNATAP -0.104275150447388 0.0057575209070771 NA NA NA hsa-miR-30c-5p RAPGEF2 -0.0469114469943097 0.565934557464627 -0.204588778569422 0.000805685668226184 MirTarget;miRNATAP -0.155592651636355 6.76556822998003e-06 NA NA NA hsa-miR-339-5p RAPGEF2 0.273253751377152 0.0185300170790638 -0.204588778569422 0.000805685668226184 MirTarget;PITA -0.119077902598672 1.80137794000772e-10 NA NA NA hsa-miR-93-5p RAPGEF2 0.139766237971122 0.101057320076629 -0.204588778569422 0.000805685668226184 MirTarget;miRNATAP -0.223193216852016 1.49044650799429e-08 NA NA NA hsa-miR-9-3p RASA1 -0.184945845984695 0.0290051908009009 -0.0629231856339159 0.184047228298798 MirTarget;miRNATAP -0.146769575121925 9.70434852945778e-09 NA NA NA hsa-miR-30b-5p RASA2 -0.0858101016322106 0.263243418521854 0.00582759452067383 0.957666009906005 mirMAP -0.265041907546631 0.000426366239598471 NA NA NA hsa-miR-30c-5p RASA2 -0.0469114469943097 0.565934557464627 0.00582759452067383 0.957666009906005 mirMAP -0.405938794612823 6.0314363327211e-08 NA NA NA hsa-miR-320a RASGRF1 0.092135599636725 0.243028758989929 -1.06685630637769 3.5468899485581e-11 miRanda -0.55677593830522 5.47838003787159e-07 NA NA NA hsa-miR-320b RASGRF1 0.283477746304177 0.0005953763020907 -1.06685630637769 3.5468899485581e-11 miRanda -0.424437233934571 5.3242357601755e-07 NA NA NA hsa-miR-320c RASGRF1 0.343259124189966 0.000248338401291051 -1.06685630637769 3.5468899485581e-11 miRanda -0.343951950195442 7.85406485832464e-06 NA NA NA hsa-miR-3913-5p RASGRF1 0.276883251911602 0.00186113779811511 -1.06685630637769 3.5468899485581e-11 mirMAP -0.381295456964508 1.31260834162521e-06 NA NA NA hsa-miR-320a RASGRF2 0.092135599636725 0.243028758989929 -0.506147835992184 9.00596821868115e-05 miRNATAP -0.499305411034718 2.45356456577931e-08 NA NA NA hsa-miR-320b RASGRF2 0.283477746304177 0.0005953763020907 -0.506147835992184 9.00596821868115e-05 miRNATAP -0.198903176007538 0.00390323705056096 NA NA NA hsa-miR-320c RASGRF2 0.343259124189966 0.000248338401291051 -0.506147835992184 9.00596821868115e-05 miRNATAP -0.293104381895496 2.35930001083077e-06 NA NA NA hsa-miR-450b-5p RASGRF2 0.270544879013992 0.00801537838499562 -0.506147835992184 9.00596821868115e-05 MirTarget -0.170204967140847 0.00269856846164706 NA NA NA hsa-miR-93-5p RASGRF2 0.139766237971122 0.101057320076629 -0.506147835992184 9.00596821868115e-05 MirTarget -0.307430286608741 0.00291957759034578 NA NA NA hsa-miR-17-3p RASGRP1 0.0217768908350733 0.801140991374649 -0.461228311355649 9.75402712538101e-05 MirTarget -0.282419356096531 3.28278622807681e-05 NA NA NA hsa-miR-21-5p RASGRP1 1.0504925175311 2.58081295984106e-11 -0.461228311355649 9.75402712538101e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.209857300737546 6.88556700859861e-09 NA NA NA hsa-miR-320a RASGRP1 0.092135599636725 0.243028758989929 -0.461228311355649 9.75402712538101e-05 miRanda -0.40023445800445 7.63439404259571e-07 NA NA NA hsa-miR-320b RASGRP1 0.283477746304177 0.0005953763020907 -0.461228311355649 9.75402712538101e-05 miRanda -0.217132175899859 0.000461300440718023 NA NA NA hsa-miR-452-5p RASGRP1 0.599327068454211 1.02031931068531e-05 -0.461228311355649 9.75402712538101e-05 MirTarget -0.158970519883108 2.01820089565616e-05 NA NA NA hsa-miR-590-3p RASGRP1 0.312951515438396 0.000480455423843996 -0.461228311355649 9.75402712538101e-05 PITA;miRanda;mirMAP -0.190087220302925 0.000894629573569115 NA NA NA hsa-miR-1224-5p RELA -0.53941068839383 0.00201058335769201 0.0739196932169914 0.126314845681798 mirMAP -0.105338562253176 5.76511309726817e-46 NA NA NA hsa-miR-138-5p RELA -0.616087649920851 1.35200027885729e-05 0.0739196932169914 0.126314845681798 miRNATAP -0.118615517312994 4.30114332551203e-37 NA NA NA hsa-miR-324-5p RELA 0.0183370482495953 0.842996782677271 0.0739196932169914 0.126314845681798 miRNAWalker2_validate;miRanda -0.154645221576587 4.11812534839311e-25 NA NA NA hsa-miR-330-5p RELA -0.262932095995605 0.0465226565966658 0.0739196932169914 0.126314845681798 miRanda -0.120880678711014 2.77817174522426e-33 NA NA NA hsa-miR-488-3p RELA -0.257955761012568 0.00280795162806256 0.0739196932169914 0.126314845681798 mirMAP -0.149905441066056 1.6489641903294e-20 NA NA NA hsa-miR-769-5p RELA -0.320572895263071 0.00425481410304398 0.0739196932169914 0.126314845681798 miRNATAP -0.185846508366017 6.56909022979932e-59 NA NA NA hsa-miR-940 RELA -0.0183807673806575 0.881747775878136 0.0739196932169914 0.126314845681798 mirMAP -0.130602708311796 2.82198893322046e-34 NA NA NA hsa-miR-491-5p RELB -0.749881113074983 8.22859263179194e-09 0.212448411871563 0.00575965527734766 miRanda -0.121117238957741 1.06040778640592e-06 NA NA NA hsa-miR-138-5p RPS6KA1 -0.616087649920851 1.35200027885729e-05 0.288456681586978 0.00241163224126765 MirTarget;miRNATAP -0.100557924867178 0.000472980824832504 NA NA NA hsa-miR-139-5p RPS6KA1 -0.647754756897633 2.15378307237163e-06 0.288456681586978 0.00241163224126765 miRanda -0.19069984741317 2.71535166303043e-10 NA NA NA hsa-miR-130b-5p RPS6KA2 0.413070888963592 1.98866876365509e-06 -0.102818285282692 0.115646038229735 mirMAP -0.126225685400395 1.01803565890354e-05 NA NA NA hsa-miR-135a-5p RPS6KA2 -0.122734612943241 0.196985964641886 -0.102818285282692 0.115646038229735 mirMAP -0.112854841699271 1.73566937878491e-05 NA NA NA hsa-miR-17-5p RPS6KA2 0.0975751369167082 0.20621110214601 -0.102818285282692 0.115646038229735 TargetScan -0.145470968862276 0.000185392599632191 NA NA NA hsa-miR-19a-3p RPS6KA2 0.0466707843731911 0.576818938277755 -0.102818285282692 0.115646038229735 MirTarget -0.109941345317371 0.000289424672612532 NA NA NA hsa-miR-19b-3p RPS6KA2 -0.0138427450847924 0.856506310673067 -0.102818285282692 0.115646038229735 MirTarget -0.107557462706343 0.0029876111469591 NA NA NA hsa-miR-3065-5p RPS6KA2 -0.262608140481507 0.0414570974148034 -0.102818285282692 0.115646038229735 mirMAP -0.118319723599353 1.9718404443808e-10 NA NA NA hsa-miR-9-3p RPS6KA2 -0.184945845984695 0.0290051908009009 -0.102818285282692 0.115646038229735 MirTarget -0.121837913254802 0.00174743974134048 NA NA NA hsa-miR-93-3p RPS6KA2 0.0778767956494004 0.272224943247293 -0.102818285282692 0.115646038229735 MirTarget -0.16728139818124 2.55778263620957e-06 NA NA NA hsa-miR-9-3p RPS6KA3 -0.184945845984695 0.0290051908009009 0.212289618101534 0.000229066563238062 mirMAP -0.321436413771326 6.97903321582923e-20 NA NA NA hsa-miR-9-5p RPS6KA4 -0.125377971246422 0.269896477802284 0.0130854757300849 0.794316298682293 MirTarget -0.253902947345698 7.37534580115171e-10 NA NA NA hsa-miR-92a-3p RPS6KA4 0.0407239381334659 0.643983393805961 0.0130854757300849 0.794316298682293 MirTarget -0.176152476964148 2.60709421711668e-07 NA NA NA hsa-miR-106b-5p RPS6KA5 0.167096183547615 0.0497544396383451 -0.408717830218735 1.63609429263568e-07 MirTarget -0.182425887248638 5.04379519857935e-05 NA NA NA hsa-miR-130a-3p RPS6KA5 0.163798739071237 0.031259491216363 -0.408717830218735 1.63609429263568e-07 MirTarget -0.141356645634873 0.00463211272810674 NA NA NA hsa-miR-130b-3p RPS6KA5 0.503911467685709 9.46590588950823e-08 -0.408717830218735 1.63609429263568e-07 MirTarget -0.150973137685502 3.25208308311392e-05 NA NA NA hsa-miR-148a-3p RPS6KA5 0.306821592493439 0.0392356958885949 -0.408717830218735 1.63609429263568e-07 miRNAWalker2_validate;miRTarBase;MirTarget -0.108518447602612 5.52436369757563e-06 20406806 MiR 148a attenuates paclitaxel resistance of hormone refractory drug resistant prostate cancer PC3 cells by regulating MSK1 expression; Computer-aided algorithms predicted mitogen- and stress-activated protein kinase MSK1 as a potential target of miR-148a; Indeed miR-148a overexpression decreased expression of MSK1; Using luciferase reporter assays we identified MSK1 as a direct target of miR-148a; MiR-148a reduced MSK1 expression by directly targeting its 3'-UTR in PC3PR cells; Furthermore MSK1 knockdown reduced paclitaxel-resistance of PC3PR cells indicating that miR-148a attenuates paclitaxel-resistance of hormone-refractory drug-resistant PC3PR cells in part by regulating MSK1 expression drug resistance prostate cancer hsa-miR-17-5p RPS6KA5 0.0975751369167082 0.20621110214601 -0.408717830218735 1.63609429263568e-07 MirTarget;TargetScan -0.19210180434249 0.000423079981268451 NA NA NA hsa-miR-18a-5p RPS6KA5 0.175320895022849 0.0732549187136286 -0.408717830218735 1.63609429263568e-07 MirTarget -0.147046419125681 1.90857118186247e-05 NA NA NA hsa-miR-199b-5p RPS6KA5 0.436298593972862 0.00200225454383871 -0.408717830218735 1.63609429263568e-07 miRanda -0.138531389599851 4.24724836249491e-09 NA NA NA hsa-miR-19a-3p RPS6KA5 0.0466707843731911 0.576818938277755 -0.408717830218735 1.63609429263568e-07 miRNAWalker2_validate;MirTarget -0.165419864301693 9.56575777738228e-05 NA NA NA hsa-miR-19b-3p RPS6KA5 -0.0138427450847924 0.856506310673067 -0.408717830218735 1.63609429263568e-07 MirTarget -0.194336484831706 0.000120718508471193 NA NA NA hsa-miR-20a-3p RPS6KA5 0.102743778777997 0.19677865359751 -0.408717830218735 1.63609429263568e-07 miRNATAP -0.113650092026147 0.00853848660044574 NA NA NA hsa-miR-20a-5p RPS6KA5 -0.0115865752288853 0.887069448776018 -0.408717830218735 1.63609429263568e-07 MirTarget -0.135847649132187 0.00664585687438844 NA NA NA hsa-miR-23a-3p RPS6KA5 0.334693010651106 0.00144448147063433 -0.408717830218735 1.63609429263568e-07 mirMAP -0.185510786707247 3.58721195441002e-07 NA NA NA hsa-miR-27a-3p RPS6KA5 0.303760032895792 0.00457375391189806 -0.408717830218735 1.63609429263568e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.181115400753636 9.30859796440021e-08 NA NA NA hsa-miR-28-5p RPS6KA5 0.104003572105781 0.153594705579534 -0.408717830218735 1.63609429263568e-07 miRanda -0.170321211281666 0.000681570609834278 NA NA NA hsa-miR-335-3p RPS6KA5 0.34540584335595 0.00043848660222294 -0.408717830218735 1.63609429263568e-07 mirMAP -0.142854344797315 6.08143339330039e-05 NA NA NA hsa-miR-454-3p RPS6KA5 0.177318549827649 0.0120865170334418 -0.408717830218735 1.63609429263568e-07 MirTarget -0.165977068759357 0.000921142674988617 NA NA NA hsa-miR-590-3p RPS6KA5 0.312951515438396 0.000480455423843996 -0.408717830218735 1.63609429263568e-07 miRanda -0.138717216340296 0.000235681721903814 NA NA NA hsa-miR-93-5p RPS6KA5 0.139766237971122 0.101057320076629 -0.408717830218735 1.63609429263568e-07 miRNAWalker2_validate;MirTarget -0.367576635620826 1.34107289051392e-09 NA NA NA hsa-miR-141-3p RPS6KA6 0.41120561991992 0.000393344390969055 -0.559322866661561 0.000339724482369036 MirTarget -0.271512659861477 5.92306630978806e-06 NA NA NA hsa-miR-15a-5p RPS6KA6 0.142658985373611 0.0536219185009004 -0.559322866661561 0.000339724482369036 MirTarget -0.556901205812393 6.3498971643411e-07 NA NA NA hsa-miR-15b-5p RPS6KA6 0.592863156692837 1.41971517354055e-10 -0.559322866661561 0.000339724482369036 MirTarget -0.551470461414379 6.00052291617387e-13 NA NA NA hsa-miR-217 RPS6KA6 0.540279882451941 0.00312206944061206 -0.559322866661561 0.000339724482369036 miRanda -0.220993695538304 2.36918823439635e-09 NA NA NA hsa-miR-26a-5p RPS6KA6 0.033823776747294 0.726610414342369 -0.559322866661561 0.000339724482369036 MirTarget -0.280985599048212 0.00112588897034342 NA NA NA hsa-miR-26b-5p RPS6KA6 -0.0984536538762768 0.231803769574623 -0.559322866661561 0.000339724482369036 miRNAWalker2_validate;MirTarget -0.311579663875516 0.00185786580921919 NA NA NA hsa-miR-335-3p RPS6KA6 0.34540584335595 0.00043848660222294 -0.559322866661561 0.000339724482369036 MirTarget -0.266298020642061 0.000233350834312626 NA NA NA hsa-miR-424-5p RPS6KA6 0.25140374049676 0.00709934939774983 -0.559322866661561 0.000339724482369036 MirTarget -0.232068332229862 0.00261816668347094 NA NA NA hsa-miR-590-3p RPS6KA6 0.312951515438396 0.000480455423843996 -0.559322866661561 0.000339724482369036 MirTarget;miRanda;mirMAP;miRNATAP -0.492427473097832 6.86073047407605e-11 NA NA NA hsa-let-7b-3p RRAS2 -0.00495618733298731 0.952288980686967 -0.0913272811525756 0.135156066352621 mirMAP;miRNATAP -0.131484100235838 2.53819396047347e-05 NA NA NA hsa-let-7f-1-3p RRAS2 0.110713086694053 0.21484524300518 -0.0913272811525756 0.135156066352621 mirMAP -0.143094236242528 2.11724325082796e-07 NA NA NA hsa-miR-106a-5p RRAS2 0.110074064773897 0.13045815990621 -0.0913272811525756 0.135156066352621 miRNATAP -0.12317886200846 0.000658480618678879 NA NA NA hsa-miR-106b-5p RRAS2 0.167096183547615 0.0497544396383451 -0.0913272811525756 0.135156066352621 miRNATAP -0.197109868266015 1.60059931740107e-09 NA NA NA hsa-miR-124-3p RRAS2 -0.506026514549291 0.0078056370358648 -0.0913272811525756 0.135156066352621 miRNAWalker2_validate -0.125689178830533 1.33296453127719e-23 NA NA NA hsa-miR-127-5p RRAS2 -0.128719168376827 0.401210814502785 -0.0913272811525756 0.135156066352621 MirTarget;PITA;miRNATAP -0.131367552633205 6.54548952205885e-16 NA NA NA hsa-miR-137 RRAS2 -0.924849266740909 1.546832202049e-06 -0.0913272811525756 0.135156066352621 miRanda -0.100839406182356 4.01361292382003e-16 NA NA NA hsa-miR-140-3p RRAS2 -0.123864258867705 0.14796686619449 -0.0913272811525756 0.135156066352621 MirTarget;PITA;miRNATAP -0.165657058581711 1.50814007589585e-05 NA NA NA hsa-miR-185-5p RRAS2 -0.0767432095218297 0.404113540276816 -0.0913272811525756 0.135156066352621 MirTarget -0.108339763839803 0.000144130105015975 NA NA NA hsa-miR-193b-3p RRAS2 0.0766333116224072 0.324723824453143 -0.0913272811525756 0.135156066352621 MirTarget -0.118927328208489 0.0004010370015633 NA NA NA hsa-miR-19b-3p RRAS2 -0.0138427450847924 0.856506310673067 -0.0913272811525756 0.135156066352621 miRNAWalker2_validate;miRNATAP -0.130788210838512 0.000420162176279474 NA NA NA hsa-miR-203a-3p RRAS2 -0.393041310603753 0.0191851699904077 -0.0913272811525756 0.135156066352621 MirTarget -0.105486967888788 2.76324948948289e-13 NA NA NA hsa-miR-23b-3p RRAS2 0.0476610245860094 0.630277683372344 -0.0913272811525756 0.135156066352621 MirTarget -0.103571566468602 0.000224509890925739 NA NA NA hsa-miR-29a-3p RRAS2 -0.224140851576083 0.0349516103550236 -0.0913272811525756 0.135156066352621 miRNATAP -0.134719689257944 9.33260365800631e-06 NA NA NA hsa-miR-29c-3p RRAS2 -0.372180390387259 0.00202634431973208 -0.0913272811525756 0.135156066352621 miRNATAP -0.106029728593073 2.49031905730787e-06 NA NA NA hsa-miR-33a-3p RRAS2 -0.158366376619191 0.0991512910387226 -0.0913272811525756 0.135156066352621 MirTarget -0.142838160675966 2.8816901396591e-08 NA NA NA hsa-miR-361-5p RRAS2 0.0107519600643302 0.882230614095565 -0.0913272811525756 0.135156066352621 miRanda -0.181785202212525 1.79177885033938e-05 NA NA NA hsa-miR-381-3p RRAS2 -0.192118086401438 0.203198554750071 -0.0913272811525756 0.135156066352621 MirTarget -0.137522270874508 1.36393568394155e-17 NA NA NA hsa-miR-496 RRAS2 -0.139833482232877 0.39597541862532 -0.0913272811525756 0.135156066352621 miRanda -0.136974714543024 1.42826027377024e-20 NA NA NA hsa-miR-543 RRAS2 -0.347737549779625 0.0157394585079683 -0.0913272811525756 0.135156066352621 miRanda -0.137924656848862 9.23831869425683e-16 NA NA NA hsa-miR-7-5p RRAS2 -0.244254069762734 0.193173919522103 -0.0913272811525756 0.135156066352621 miRNAWalker2_validate;MirTarget;miRNATAP -0.1380263611689 4.59809169654478e-27 NA NA NA hsa-miR-93-5p RRAS2 0.139766237971122 0.101057320076629 -0.0913272811525756 0.135156066352621 miRNAWalker2_validate -0.203144889149896 5.69524711899527e-06 NA NA NA hsa-miR-22-5p SOS1 0.0437233965539527 0.639996108995995 0.00523748905885846 0.912745973623718 miRNATAP -0.124027312186166 1.41352250447066e-15 NA NA NA hsa-miR-30a-5p SOS1 -0.062942936611238 0.513851954700252 0.00523748905885846 0.912745973623718 mirMAP;miRNATAP -0.177492800844273 6.3171352970898e-13 NA NA NA hsa-miR-30b-5p SOS1 -0.0858101016322106 0.263243418521854 0.00523748905885846 0.912745973623718 mirMAP -0.16385231555963 4.41286025144966e-13 NA NA NA hsa-miR-30c-2-3p SOS1 -0.18630560418806 0.0313113706136533 0.00523748905885846 0.912745973623718 MirTarget -0.104452765489338 1.12374921832207e-08 NA NA NA hsa-miR-30c-5p SOS1 -0.0469114469943097 0.565934557464627 0.00523748905885846 0.912745973623718 mirMAP;miRNATAP -0.197561323004552 1.3758821302056e-18 NA NA NA hsa-miR-361-5p SOS1 0.0107519600643302 0.882230614095565 0.00523748905885846 0.912745973623718 miRanda -0.115873078362459 3.5425762216149e-06 NA NA NA hsa-miR-365a-3p SOS1 -0.184222766207919 0.0292663235724171 0.00523748905885846 0.912745973623718 miRNATAP -0.149763665687287 4.3259532044635e-18 NA NA NA hsa-miR-664a-3p SOS1 0.0413918462467198 0.611334357897022 0.00523748905885846 0.912745973623718 mirMAP -0.132986198696247 2.29333790618546e-13 NA NA NA hsa-miR-146b-5p SOS2 0.441078059667297 0.000237619929889385 -0.136173831265531 0.0089381592916821 miRanda -0.155137029146937 3.46260583915288e-27 NA NA NA hsa-miR-15a-5p SOS2 0.142658985373611 0.0536219185009004 -0.136173831265531 0.0089381592916821 miRNATAP -0.11015727851104 9.81799896258958e-05 NA NA NA hsa-miR-15b-5p SOS2 0.592863156692837 1.41971517354055e-10 -0.136173831265531 0.0089381592916821 miRNATAP -0.149377221011986 7.33700935351651e-15 NA NA NA hsa-miR-664a-3p SOS2 0.0413918462467198 0.611334357897022 -0.136173831265531 0.0089381592916821 mirMAP -0.18595244526209 1.63522338473879e-18 NA NA NA hsa-miR-9-5p SRF -0.125377971246422 0.269896477802284 0.114198652265422 0.0124159673997605 miRTarBase -0.112358814005573 0.00036523246433207 NA NA NA hsa-miR-128-3p STK3 -0.781932174412672 7.1812756321342e-10 0.162626811287567 0.00329060005025782 miRNAWalker2_validate;MirTarget -0.199733128312276 4.34671505953338e-27 NA NA NA hsa-miR-137 STK3 -0.924849266740909 1.546832202049e-06 0.162626811287567 0.00329060005025782 PITA;miRanda -0.128580688622843 1.28303824834505e-31 NA NA NA hsa-miR-582-5p STK3 -0.215764335500665 0.0760892640434509 0.162626811287567 0.00329060005025782 MirTarget -0.17160578052705 7.69439061309188e-22 NA NA NA hsa-miR-9-5p STK3 -0.125377971246422 0.269896477802284 0.162626811287567 0.00329060005025782 miRNAWalker2_validate;MirTarget -0.252419272315067 3.56092429945605e-07 NA NA NA hsa-miR-9-3p STK4 -0.184945845984695 0.0290051908009009 0.0665699609689918 0.12278898652794 MirTarget;miRNATAP -0.102292280821186 7.36616530731824e-07 NA NA NA hsa-miR-30a-5p STMN1 -0.062942936611238 0.513851954700252 -0.107316866124608 0.166274532126969 miRNAWalker2_validate -0.248150681185083 8.15324640051993e-08 NA NA NA hsa-miR-106a-5p TAOK1 0.110074064773897 0.13045815990621 -0.0623612691694069 0.627485096235085 miRNATAP -0.242378659414766 0.0025237911341927 NA NA NA hsa-miR-15a-5p TAOK1 0.142658985373611 0.0536219185009004 -0.0623612691694069 0.627485096235085 MirTarget -0.235079813980325 0.00922664801238202 NA NA NA hsa-miR-19a-3p TAOK1 0.0466707843731911 0.576818938277755 -0.0623612691694069 0.627485096235085 MirTarget;miRNATAP -0.243981796767955 0.000402648827151151 NA NA NA hsa-miR-19b-3p TAOK1 -0.0138427450847924 0.856506310673067 -0.0623612691694069 0.627485096235085 MirTarget;miRNATAP -0.339239155150693 3.52193328096991e-05 NA NA NA hsa-miR-200c-3p TAOK1 0.413752622631695 8.6936333715621e-06 -0.0623612691694069 0.627485096235085 MirTarget;mirMAP;miRNATAP -0.204187047827091 0.000531685489493984 NA NA NA hsa-miR-20a-5p TAOK1 -0.0115865752288853 0.887069448776018 -0.0623612691694069 0.627485096235085 miRNATAP -0.221717446331506 0.00638227082033133 NA NA NA hsa-miR-26b-5p TAOK1 -0.0984536538762768 0.231803769574623 -0.0623612691694069 0.627485096235085 mirMAP;miRNATAP -0.248596840598653 0.00192616484714172 NA NA NA hsa-miR-30b-5p TAOK1 -0.0858101016322106 0.263243418521854 -0.0623612691694069 0.627485096235085 miRNAWalker2_validate;MirTarget -0.39079729455871 5.79962735628188e-06 NA NA NA hsa-miR-30c-5p TAOK1 -0.0469114469943097 0.565934557464627 -0.0623612691694069 0.627485096235085 MirTarget;miRNATAP -0.559451743250185 6.48978982524148e-11 NA NA NA hsa-miR-320a TAOK1 0.092135599636725 0.243028758989929 -0.0623612691694069 0.627485096235085 mirMAP;miRNATAP -0.270499672789339 0.00196353879790419 NA NA NA hsa-miR-339-5p TAOK1 0.273253751377152 0.0185300170790638 -0.0623612691694069 0.627485096235085 miRanda -0.14614552984123 0.00207013164148123 NA NA NA hsa-miR-342-3p TAOK1 -0.125683829770877 0.105810751640137 -0.0623612691694069 0.627485096235085 miRanda -0.268831714551118 0.000719849564414559 NA NA NA hsa-miR-34c-5p TAOK1 0.181931113688093 0.257266965617363 -0.0623612691694069 0.627485096235085 miRanda -0.106892134703214 0.00163699129451873 NA NA NA hsa-miR-374a-3p TAOK1 0.176226170437625 0.0343958848425446 -0.0623612691694069 0.627485096235085 mirMAP -0.265659639730016 0.00128566053844061 NA NA NA hsa-miR-425-5p TAOK1 -0.0412837711174561 0.682284485592858 -0.0623612691694069 0.627485096235085 miRNAWalker2_validate -0.185569802078859 0.00135655995719868 NA NA NA hsa-miR-454-3p TAOK1 0.177318549827649 0.0120865170334418 -0.0623612691694069 0.627485096235085 mirMAP -0.294316300658381 0.00029301987766773 NA NA NA hsa-miR-501-3p TAOK1 0.0726267165568464 0.382729320534971 -0.0623612691694069 0.627485096235085 miRNATAP -0.244400913837171 0.000387425960448058 NA NA NA hsa-miR-576-5p TAOK1 0.106482276040047 0.194379152564166 -0.0623612691694069 0.627485096235085 mirMAP -0.196272995984347 0.00396051752821132 NA NA NA hsa-miR-664a-3p TAOK1 0.0413918462467198 0.611334357897022 -0.0623612691694069 0.627485096235085 mirMAP -0.204603539159136 0.00326498468500138 NA NA NA hsa-miR-9-3p TAOK1 -0.184945845984695 0.0290051908009009 -0.0623612691694069 0.627485096235085 mirMAP -0.305314730546719 0.000550441133291852 NA NA NA hsa-miR-93-5p TAOK1 0.139766237971122 0.101057320076629 -0.0623612691694069 0.627485096235085 miRNATAP -0.349426009811031 0.000452411807147992 NA NA NA hsa-miR-28-3p TAOK2 0.139444423971018 0.0811187936164314 -0.0813674892170386 0.0717563786798701 PITA -0.122931595280665 2.99103398154944e-13 NA NA NA hsa-miR-106a-5p TAOK3 0.110074064773897 0.13045815990621 -0.111524646709549 0.0389557273641124 MirTarget -0.119142444071567 7.29130626353932e-07 NA NA NA hsa-miR-18a-5p TAOK3 0.175320895022849 0.0732549187136286 -0.111524646709549 0.0389557273641124 miRNATAP -0.135976065172003 1.5413618794546e-16 NA NA NA hsa-miR-193b-3p TAOK3 0.0766333116224072 0.324723824453143 -0.111524646709549 0.0389557273641124 miRNAWalker2_validate -0.115831399072721 2.14454052437688e-07 NA NA NA hsa-miR-197-3p TAOK3 -0.176796295244328 0.0837698554789217 -0.111524646709549 0.0389557273641124 miRNATAP -0.10028491625684 4.64265774476201e-08 NA NA NA hsa-miR-200b-3p TAOK3 0.245768526504511 0.0580744465744737 -0.111524646709549 0.0389557273641124 MirTarget;TargetScan -0.107366276080739 2.60237944756442e-17 NA NA NA hsa-miR-200c-3p TAOK3 0.413752622631695 8.6936333715621e-06 -0.111524646709549 0.0389557273641124 MirTarget -0.157247947745412 6.35874724757545e-20 NA NA NA hsa-miR-361-5p TAOK3 0.0107519600643302 0.882230614095565 -0.111524646709549 0.0389557273641124 miRanda -0.210694747926669 3.8441350925132e-14 NA NA NA hsa-miR-590-3p TAOK3 0.312951515438396 0.000480455423843996 -0.111524646709549 0.0389557273641124 miRanda -0.132093716522424 3.468100139609e-13 NA NA NA hsa-miR-93-5p TAOK3 0.139766237971122 0.101057320076629 -0.111524646709549 0.0389557273641124 MirTarget -0.158186436970282 1.16890427268268e-07 NA NA NA hsa-miR-139-5p TGFB1 -0.647754756897633 2.15378307237163e-06 0.188661409906809 0.0283645098828165 miRanda -0.257914873895623 5.01185822136258e-24 NA NA NA hsa-let-7a-3p TGFB2 0.0530563276543763 0.370749834463566 0.770124480266937 2.43471584041631e-07 miRNATAP -0.442723562700544 0.000358820362673608 NA NA NA hsa-miR-181a-2-3p TGFB2 -0.0630409614874416 0.473088318215936 0.770124480266937 2.43471584041631e-07 MirTarget -0.480565043297097 4.63300164322775e-06 NA NA NA hsa-miR-9-3p TGFB2 -0.184945845984695 0.0290051908009009 0.770124480266937 2.43471584041631e-07 MirTarget -0.502297808087689 1.67671098075053e-06 NA NA NA hsa-let-7d-5p TGFBR1 0.111345229817909 0.0872634398336815 0.339248208669654 4.04767020934912e-07 miRNAWalker2_validate;miRNATAP -0.154436649206706 0.00201422979804352 NA NA NA hsa-let-7g-5p TGFBR1 -0.0253396334608382 0.742556489443668 0.339248208669654 4.04767020934912e-07 miRNATAP -0.119325470730491 0.00744772702777702 NA NA NA hsa-miR-101-5p TGFBR1 -0.263105484860745 0.00306900408113868 0.339248208669654 4.04767020934912e-07 mirMAP -0.170663135357559 1.09969750824995e-08 NA NA NA hsa-miR-124-3p TGFBR1 -0.506026514549291 0.0078056370358648 0.339248208669654 4.04767020934912e-07 miRNATAP -0.111716058691644 9.37933645710229e-17 NA NA NA hsa-miR-128-3p TGFBR1 -0.781932174412672 7.1812756321342e-10 0.339248208669654 4.04767020934912e-07 miRNAWalker2_validate;miRTarBase -0.210164447590872 1.78152956429912e-22 NA NA NA hsa-miR-3200-3p TGFBR1 -0.485743434053711 2.90556089083004e-06 0.339248208669654 4.04767020934912e-07 miRNATAP -0.163923881348339 1.17145766418329e-10 NA NA NA hsa-miR-490-3p TGFBR1 -0.834268051506884 5.26203010743215e-06 0.339248208669654 4.04767020934912e-07 PITA;miRanda;miRNATAP -0.116809003131924 7.17389189955076e-17 NA NA NA hsa-miR-7-1-3p TGFBR1 -0.0894475316162393 0.37322359785108 0.339248208669654 4.04767020934912e-07 mirMAP -0.193412951927122 5.6104947426979e-14 NA NA NA hsa-miR-769-5p TGFBR1 -0.320572895263071 0.00425481410304398 0.339248208669654 4.04767020934912e-07 PITA;miRNATAP -0.142395371930849 1.58733943690247e-09 NA NA NA hsa-miR-885-5p TGFBR1 -0.423614695846868 1.14213289528402e-05 0.339248208669654 4.04767020934912e-07 miRNATAP -0.210309423588542 8.19387972024476e-15 NA NA NA hsa-miR-935 TGFBR1 -0.277848050075718 0.02166231531395 0.339248208669654 4.04767020934912e-07 mirMAP -0.181329459956271 3.00813498843219e-17 NA NA NA hsa-miR-1179 TGFBR2 -0.117056451908751 0.310989525634765 0.325097304090624 3.603719155359e-05 PITA;miRNATAP -0.142555681024439 5.0092083961168e-07 NA NA NA hsa-miR-20a-5p TGFBR2 -0.0115865752288853 0.887069448776018 0.325097304090624 3.603719155359e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.153978368220713 0.00117402220263866 NA NA NA hsa-miR-9-3p TGFBR2 -0.184945845984695 0.0290051908009009 0.325097304090624 3.603719155359e-05 miRNATAP -0.335699632305666 4.21320029336482e-11 NA NA NA hsa-miR-9-5p TGFBR2 -0.125377971246422 0.269896477802284 0.325097304090624 3.603719155359e-05 miRNATAP -0.68717125660116 2.86156196036347e-24 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-125a-5p TP53 -0.0833349424517387 0.325440200253607 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate;miRTarBase;miRanda -0.375445863722298 1.2184854773952e-16 26389681;21777146;23079745 Mechanistically inactivation of miR-125a during cervical carcinogenesis was caused by HPV suppression of p53 expression;In addition wild-type p53 mRNA and protein expression was increased by hsa-miR-125a-5p overexpression; Moreover blocking wild-type p53 attenuated the effect of hsa-miR-125a-5p on apoptosis; In loss-of-function experiments wild-type p53 mRNA and protein expression was decreased by blocking hsa-miR-125a-5p; The effect of hsa-miR-125a-5p inhibitor on apoptosis was also weakened by blocking wild-type p53;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity tumorigenesis;; cervical and endocervical cancer;lung cancer;liver cancer hsa-miR-125b-5p TP53 -0.0119698382910496 0.890233923197358 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate;miRTarBase -0.294628443669371 1.07324994036762e-07 24169356;24846940;26335100;24137477;26686386;24402874;21399871;23585871;24762088;23079745 MiR 125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK independent pathways; Further studies reveal that p53 is regulated by miR-125b; However downregulation of the endogenous miR-125b also results in p53-independent apoptotic pathway leading to apoptosis in p53 mutated U251 cells and p53 knockdown U87 cells;The results revealed that hsa-miR-125b may regulate multiple biological processes and signal transduction pathways and drug-resistant occurrence is associated with cell proliferation cell apoptosis cell cycle and signaling pathways including MAPK Wnt and p53;The carboxy terminal domain of connexin 43 CT Cx43 modulates the expression of p53 by altering miR 125b expression in low grade human breast cancers; In addition CT-Cx43 was exogenously expressed in the breast cancer-derived cell line MCF-7 and its effect on the expression of miR-125b and its downstream target p53 were evaluated as well as its effect on cellular proliferation and death using MTT and LDH assays respectively; Interestingly we found that miR-125b a negative regulator of p53 exhibited an inverse expression relationship with CT-Cx43 in the breast cancer samples tested;TP53 and hsa-miR-125b were observed to form a self-adaptation association;In this study we have investigated the delivery and transfection of wild-type wt- p53 and microRNA-125b miR-125b expressing plasmid DNA in SK-LU-1 human lung adenocarcinoma cells as well as in KrasG12D/p53fl/fl KP genetically engineered mouse model of lung cancer;miR-34a is directly regulated by p53 and acts as tumor suppressor while miR-125b plays a significant role in immune response and apoptosis;In vitro assays revealed that overexpression of miR-125b repressed the endogenous level of p53 protein in human colorectal cancer cells;In this study we further extend our studies by showing that miR-125b represses the protein product of the ink4a/ARF locus p14ARF in two prostate cancer cell lines LNCaP wild type-p53 and 22Rv1 both wild type and mutant p53 as well as in the PC-346C prostate cancer xenograft model that lentivirally overexpressed miR-125b;A stable overexpression of miR-125b in human melanoma cell line Mel-Juso resulted in a G0/G1 cell cycle block and emergence of large cells expressing senescence markers: senescence-associated beta-galactosidase p21 p27 and p53;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity; To show the clinical significance of these findings mutations in the DNA binding domain of p53 and promoter methylation of miR-125b were investigated; Four out of nine patients with induced SIRT7 carried mutations in the p53 gene and one patient showed hypermethylation of the miR-125b promoter region ;;;;;immune resistance;;;; glioblastoma;gastric cancer;breast cancer;pancreatic cancer;lung cancer;cervical and endocervical cancer;colorectal cancer;prostate cancer;melanoma;liver cancer hsa-miR-150-5p TP53 0.0645271721519611 0.513295658828718 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate -0.156281214913021 3.09404029899862e-06 23747308;23228962 miR 150 promotes the proliferation of lung cancer cells by targeting P53; Here we demonstrate that miR-150 is aberrantly upregulated in lung cancer tissue and negatively correlates with the expression of the proapoptotic gene p53 but not EGR2; We show that miR-150 specifically targets the 3'-UTR of p53 and regulates its expression; Inhibition of miR-150 effectively delays cell proliferation and promotes apoptosis accompanied by increased p53 protein expression;miR-150 and miR-3940-5p were found to be significantly downregulated in p53 IHC-positive NSCLC cases and were negatively correlated with p53 mRNA; miR-150 and miR-3940-5p may affect p53 expression through a direct or indirect pathway ; lung cancer;lung squamous cell cancer hsa-miR-221-3p TP53 -0.0109507285071775 0.936440693394519 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate -0.143405645468124 6.89189438710031e-10 20880178;24324033 Circulating miR 221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression; The correlation between miR-221 levels and protein levels of p53 CEA ER and PR clinicopathological features or overall survival was analyzed; The immunohistochemistry analysis demonstrates a significant correlation between plasma miR-221 level and p53 expression; The direct amplification of plasma miR-221 can be used as a potential noninvasive molecular marker for diagnosis and prognosis of CRC and is correlated with p53 expression;Interestingly miR-221 can activate the p53/mdm2 axis by inhibiting MDM2 and in turn p53 activation contributes to miR-221 enhanced expression; Moreover by modulating the p53 axis miR-221 impacts cell-cycle progression and apoptotic response to doxorubicin in hepatocellular carcinoma-derived cell lines; These data were confirmed in clinical specimens of hepatocellular carcinoma in which elevated miR-221 expression was associated with the simultaneous presence of wild-type p53 and DNA hypomethylation poor survival;worse prognosis;progression;drug resistance colorectal cancer;liver cancer hsa-miR-222-3p TP53 0.107117065575197 0.423818119725697 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate -0.142653482163308 1.2671214916531e-09 NA NA NA hsa-miR-30d-5p TP53 -0.0607010868720046 0.471410043548794 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate -0.336903694979927 3.32137008004591e-09 NA NA NA hsa-miR-324-5p TP53 0.0183370482495953 0.842996782677271 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate -0.170645382602635 1.21583558752455e-06 NA NA NA hsa-miR-338-3p TP53 -0.39963704679384 0.0034410643220691 0.346312114104146 1.42081328137217e-05 miRanda -0.117560999445537 4.2049029410775e-06 NA NA NA hsa-miR-34a-5p TP53 0.143472919835524 0.211283228567057 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate -0.127236433475415 7.74576992902642e-06 23155233;19773441;25572695;25123132;22438124;21702042;22292433;21383543;25982144;19443717;26790955;24642471;22198213;25362853;23036084;19421141;24444609;20186752;22457788;27186405;21731696;19736307;26879132;23569431;25771001;23292869;24209638;24957404;21240262;24503183;22102859;18803879;24630988;25895459;25894979;19714243;26944831;19921694;21909380;25789847;23450486;24402874;24337371;18497571;25490093;22593438;24528540;20145172;23349340;25038915;21321636;23632240;23624843;19029026;20309940;22810507;23862748;25932212;18834855;21225432 The high miR-34a expression level in the cells after irradiation at 60 Gy reduced the p53 expression level;MicroRNA-34a miR-34a is a transcriptional target of p53 that is down-regulated in some cancer cell lines; Analysis of human specimens showed that miR-34a expression is down-regulated in glioblastoma tissues as compared with normal brain and in mutant p53 gliomas as compared with wild-type p53 gliomas;For this purpose cell viability assay Realtime quantitative PCR for mRNA quantification western blot for essential protein expression p53 silencing by shRNA and miR-34a knockdown were performed in the present study; PRE also elevated p53 protein and triggered miR-34a expression;As expected p53 loss caused downregulation of established p53 targets e.g p21 and miR-34 family and increased proliferation in both luminal and basal-like cell lines;Moreover re-expression of miR-34a by transfection in NSCLC cells resulted in inhibition of cell growth and invasiveness induction of apoptosis and enhanced p53 activity;MiR 34a chemosensitizes bladder cancer cells to cisplatin treatment regardless of p53 Rb pathway status; MiR-34a is a downstream effector of p53 that has been shown to target several molecules associated with cell cycle and cell survival pathways; As alterations in these pathways are frequent in muscle invasive transitional cell carcinoma of the bladder MI-TCC for example mutation or loss of p53 and Rb the goal of this study was to determine whether manipulation of miR-34a expression levels could abrogate the effect of these alterations and sensitize bladder cancer cells to chemotherapy;Reporter assay further showed that NF-kappaB-induced miR-34a transcriptional activity was reduced by p53 impairment; And wildtype p53 is responsible for NF-kappaB-mediated miR-34a transcriptional activity but not for NF-kappaB binding;Recently miR-34 family has been shown to be part of the p53 pathway which is frequently involved in lung cancer and the expression of miR-34 has been reported to be regulated by DNA methylation;5 Aminolevulinic acid mediated sonodynamic therapy induces anti tumor effects in malignant melanoma via p53 miR 34a Sirt1 axis; Therefore the p53 miR-34a and SIRT1 constituted a positive feedback loop;miR-34a expression could be increased in Y79 cells but not Weri-Rb1 cells after p53 activation; This differential regulation was not caused by genomic alterations at the miR-34a p53 binding site or mature gene;Conversely kallistatin stimulated expression of the tumorigenic suppressors miR-34a and p53;Members of the miR-34 family are induced by the tumor suppressor p53 and are known to inhibit epithelial-to-mesenchymal transition EMT and therefore presumably suppress the early phases of metastasis;MicroRNA-34a miR-34a a transcriptional target of p53 is a well-known tumor suppressor gene; Moreover we found that miR-34a was downregulated in 25 of 40 62.5% colon cancer tissues as compared with the adjacent normal colon tissues and that the expression of miR-34a was correlated with the DNA-binding activity of p53;Ectopic expression of miR-34a-5p in p53 wild-type colon cancer cell HCT116 significantly inhibited cell growth migration invasion and metastasis; miR-34a-5p induced cell apoptosis cell cycle arrest at G1 phase and p53 transcription activity in HCT116 cells but not in the HCT116 p53 knockout p53-/- cells; miR-34a-5p significantly suppressed the HCT116 growth in vivo whereas it showed no effect on the HCT116 p53-/- xenograft indicating that the growth-inhibiting effect by miR-34a-5p was dependent on p53;microRNA 34a sensitizes lung cancer cell lines to DDP treatment independent of p53 status; However the precise biological role of miR-34a in p53 deficient lung cancer cell lines remains largely elusive; Overall in this study we found the proliferation inhibition function of miR-34a in vitro in lung cancer cell lines is p53 independent and also demonstrated the combination therapeutic potential of miR-34a and DDP in lung cancer cell lines;In particular mammalian miR-34 is upregulated by p53 in response to radiation but little is known about the role of this miRNA in vivo; These findings show a role for mir-34 in both apoptotic and non-apoptotic cell death in vivo much like that of cep-1 the C elegans p53 homolog;Tumor-suppressive miR-34a a direct target of p53 has been shown to target several molecules of cell survival pathways; Here we show that capsaicin-induced oxidative DNA damage culminates in p53 activation to up-regulate expression of miR-34a in non-small cell lung carcinoma NSCLC cells;Accumulating evidence suggests that miR-34a as a key mediator of p53 tumor suppression is aberrantly expressed in human cancers; Bioinformatics analysis produced a protein-protein interaction network which revealed that the p53 signaling pathway and cell cycle pathway were two major hubs containing most of the proteins regulated by miR-34a;Studies have demonstrated that miR-34a which is a direct target of the p53 tumor suppressor gene functions as a tumor suppressor and is associated with the tumor growth and metastasis of various human malignances;Knockdown of oncoprotein E6 expression of human papillomavirus in SiHa and HeLa cells by siRNAs lead to an increased protein level of p53 decreased level of miR-34a as well as reduced Warburg effect;miR-34a is known as a p53 regulated tumor suppressor microRNA in many cancer types;In addition in patients with sufficient tumor tissue we assessed p53 mutations and the methylation status of the MIRN34A gene promoter region and correlated these findings with miR-34a expression; Patients with both p53 mutations and low miR-34a levels had the highest probability of relapse P = 0.001;Particularly miR-34a has been revealed to be a direct transcriptional target of p53 which is frequently mutated in epithelial ovarian carcinomas especially in high grade serous cancer; The aim of this study was to investigate the clinical relevance of mir34a as well as its promoter methylation in a subset of 133 ovarian cancers with a special focus on the p53 mutation status the dualistic type I and type II ovarian cancer model and the different histotypes; The expression of miR-34a was found lower in type II than in type I cancers p = 0.037 in p53 mutated as compared to p53 wild type cancers p = 0.003 and in high grade compared to in low grade cancers p = 0.028; The inverse association between miR-34a expression and grading p53 mutation status and dualistic tumor type classification together with its prognostic relevance may underline the tumor-suppressive character of miR-34a in ovarian cancer;As a direct target gene of p53 miR-34a has been suggested to mediate the tumor suppressor function of p53;Further studies indicated that PEG4000-TQ-Nps could significantly increase the expression of miR-34a through p53;Downregulation of miR 34a in breast tumors is not associated with either p53 mutations or promoter hypermethylation while it correlates with metastasis; Recent studies have shown that p53 upregulates miR-34 family leading to direct repression of several key oncogenes; In this study expression of mature miR-34a in breast tumors with wild-type p53 was investigated in order to find any correlation between dysregulation of miR-34a expression and breast cancer; In about 40 % of the wild-type p53 samples miR-34a was significantly downregulated; This study has provided evidence that miR-34a expression can be affected in a significant proportion of breast tumors independent of p53; Knowledge of miR-34a status may provide additional useful information regarding the nature of breast tumors especially when p53 testing does not show any aberration;Among these we found well studied molecules such as the miR-17-92 cluster comprising potent oncogenic microRNA and miR-34 recently found to interact with p53;The results demonstrated that miR-199a and miR-34a could induce the apoptosis of human osteosarcoma cells via p53 signalling pathway;Here we show through expression analysis that miR-34a a p53 target was underexpressed in CD44+ prostate cancer cells purified from xenograft and primary tumors;Members of the miR-34 family have been shown to be transcriptional targets of the tumour suppressor gene P53;Functional genomic analysis highlighted a novel regulatory role of the transcription factor MAZ apart from the known control by p53 on the expression of miR-34a and a number of miR-34a targets; Our analysis for regulatory loops suggest that MAZ and p53 transcription factors co-operate in modulating miR-34a as well as miR-34a targets involved in several cellular pathways;Restoration of tumor suppressor miR 34 inhibits human p53 mutant gastric cancer tumorspheres; MicroRNA miR-34 was recently found to be a direct target of p53 functioning downstream of the p53 pathway as a tumor suppressor; Our results demonstrate that in p53-deficient human gastric cancer cells restoration of functional miR-34 inhibits cell growth and induces chemosensitization and apoptosis indicating that miR-34 may restore p53 function;miR 34 cooperates with p53 in suppression of prostate cancer by joint regulation of stem cell compartment; The miR-34 family was originally found to be a direct target of p53 and is a group of putative tumor suppressors; Here we report that mice with prostate epithelium-specific inactivation of mir-34 and p53 show expansion of the prostate stem cell compartment and develop early invasive adenocarcinomas and high-grade prostatic intraepithelial neoplasia whereas no such lesions are observed after inactivation of either the mir-34 or p53 genes alone by 15 months of age; Consistently combined deficiency of p53 and miR-34 leads to acceleration of MET-dependent growth self-renewal and motility of prostate stem/progenitor cells; Our study provides direct genetic evidence that mir-34 genes are bona fide tumor suppressors and identifies joint control of MET expression by p53 and miR-34 as a key component of prostate stem cell compartment regulation aberrations in which may lead to cancer;The miR-34 family is directly transactivated by tumor suppressor p53 which is frequently mutated in various cancers; however the effect of miR-34a on the ovarian cancer cells remains unclear;The microRNA-34 family miR-34a -34b and -34c have been reported to be tumor suppressor microRNAs miRNAs that are regulated by the TP53 and DNA hypermethylation; To elucidate the roles of miR-34 family in colon carcinogenesis miR-34a/b/c were measured in tumors and adjacent noncancerous tissues from 159 American and 113 Chinese colon cancer patients using quantitative RT-PCR and we examined associations between miR-34a/b/c expression with TNM staging cancer-specific mortality TP53 mutation status and Affymetrix microarray data;Transcription of the three miRNA miR-34 family members was recently found to be directly regulated by p53; Our results demonstrate that miR-34 may restore at least in part the tumor suppressing function of the p53 in p53-deficient human pancreatic cancer cells;p53 status was not correlated with miR-34a;The above results suggest that microRNA-34a is one of the important components of PRIMA-1-induced apoptotic network in the cancer cells harboring mutant p53;MicroRNA-34a miR-34a is a transcriptional target of p53 and is down-regulated in pancreatic cancer;Phytochemical regulation of the tumor suppressive microRNA miR 34a by p53 dependent and independent responses in human breast cancer cells; The tumor suppressive microRNA miR-34a is transcriptionally regulated by p53 and shown to inhibit breast cancer cell proliferation as well as being a marker of increased disease free survival; Human breast cancer cells expressing wild-type MCF-7 or mutant p53 T47D were treated with a concentration range and time course of each phytochemical under conditions of cell cycle arrest as detected by flow cytometry to examine the potential connection between miR-34a expression and their anti-proliferative responses; Our results suggest that miR-34a is an essential component of the anti-proliferative activities of I3C artemisinin and artesunate and demonstrate that both wild-type p53 dependent and independent pathways are responsible for miR-34a induction;Compared with p53 normal group the expression level of miR-34a was significantly lower in p53 deletion group;miR-34a is directly regulated by p53 and acts as tumor suppressor while miR-125b plays a significant role in immune response and apoptosis;The microRNA miR-34 family is a direct transcriptional target of tumor-suppressor TP53 and loss of miR-34 function may impair TP53-mediated cell cycle arrest and apoptosis;It appears that AR-dependent inhibition of p53 resulted in suppression of miR-34a and -34c expression;In this study we evaluated the cascade of events determined by etoposide-induced DNA damage in OS cell lines with different p53 status focusing on methylation status and expression of miR-34a that modulate tumor cell growth and cell cycle progression; Our results suggest that the open and unmethylated conformation of the miR-34a gene may be regulated by p53 able to bind the gene promoter;The miR-34 family under-expressed in-non small cell lung cancers NSCLCs are effectors of p53 activation upon irradiation of cells;MiR-34a a direct p53 target gene possesses tumor-suppressive properties as they mediate apoptosis cell cycle arrest and senescence;The miR-34 family is directly transactivated by tumor suppressor p53 which is frequently mutated in human epithelial ovarian cancer EOC; miR-34a expression is decreased in 100% and miR-34b*/c in 72% of EOC with p53 mutation whereas miR-34a is also downregulated in 93% of tumors with wild-type p53; Finally miR-34 reconstitution experiments in p53 mutant EOC cells resulted in reduced proliferation motility and invasion the latter of which was dependent on MET expression;miR-34a is transcriptionally induced by the tumor suppressor gene p53 which is often downregulated in non-small cell lung cancer NSCLC;In conclusion overexpression of PEBP4 reduced the sensitivity of A549 cells to DDP-induced cytotoxicity mainly through the altered expression of the p53 protein or the modulation of miR-34a;To investigate the effects of miR-449 and miR-34 on cell growth cell cycle and target gene expression based on these miRNA different expressions in ovarian cancer cell lines SKOV3 and SKOV3-ipl both with mutation of p53;Numerous studies have focused on the association between miR-34 family members which are direct p53 targets and carcinogenesis of many cancers including hepatocellular carcinoma HCC;p53 regulates nuclear GSK 3 levels through miR 34 mediated Axin2 suppression in colorectal cancer cells;MicroRNA-34a miR-34a a potential key effector of the p53 tumor-suppressor gene was studied as a potential tumor suppressor in uveal melanoma;The miR-34 family members are direct transcriptional targets of tumor suppressor p53 and loss of miR-34 function can impair p53-mediated cell cycle arrest and apoptosis;Profiling microRNA miRNA expression delineated TP53 alteration-associated miRNA profiles and identified miR-34a and miR-100 as the most significantly down- and upregulated miRNA respectively; Clinically low miR-34a expression and TP53 alterations predicted for chemotherapy resistance and inferior outcome; Thus detailed molecular profiling links impaired p53 to decreased miR-34a expression but also identifies p53-independent miR-34a induction mechanisms as shown in TP53biallelic altered cell lines treated with 15-deoxy-Δ1214-prostaglandin;MiR-34a a direct target of p53 has been shown to target several molecules associated with the cell cycle and cell survival pathways and its dysregulation is implicated in cancer drug resistance or sensitivity in several human cancers;MicroRNA-34a miR-34a is a direct transcriptional target of p53 and links tumor suppressor function and the oncogenic pathways in some cancers;Tumor suppressor p53 transcriptionally regulates expression of microRNA-34a which confers translational inhibition and mRNA degradation of genes involved in cell cycle control and apoptosis; MiR-34a expression was markedly reduced in p53-null PC3 cells and p53-mutated DU145 cells compared with LNCaP cells expressing wild-type p53;The microRNA encoding genes miR-34a and miR-34b/c represent direct p53 target genes and possess tumor suppressive properties as they mediate apoptosis cell cycle arrest and senescence; In the colorectal cancer samples a statistically significant correlation of miR-34a methylation and the absence of p53 mutation was detected; The mutual exclusiveness of miR-34a methylation and p53 mutation indicates that miR-34a inactivation may substitute for loss of p53 function in cancer ;;;;;poor survival;;;malignant trasformation;;;metastasis;;metastasis;;drug resistance;poor survival;;metastasis;;;;;;;metastasis;;;;;;;motility;;staging;tumorigenesis;;;;;drug resistance;poor survival;;immune resistance;;;progression;;;motility;;;;tumorigenesis;;;;drug resistance;poor survival;drug resistance;;; glioblastoma;glioblastoma;bladder cancer;breast cancer;lung squamous cell cancer;bladder cancer;esophageal cancer;lung squamous cell cancer;melanoma;retinoblastoma;breast cancer;colorectal cancer;colon cancer;colorectal cancer;lung cancer;breast cancer;lung squamous cell cancer;liver cancer;sarcoma;cervical and endocervical cancer;lung squamous cell cancer;lung squamous cell cancer;ovarian cancer;sarcoma;breast cancer;breast cancer;head and neck cancer;sarcoma;prostate cancer;kidney renal cell cancer;breast cancer;gastric cancer;prostate cancer;ovarian cancer;colon cancer;pancreatic cancer;esophageal cancer;lung cancer;pancreatic cancer;breast cancer;B cell lymphoma;cervical and endocervical cancer;colorectal cancer;prostate cancer;sarcoma;lung squamous cell cancer;esophageal cancer;ovarian cancer;lung squamous cell cancer;lung cancer;ovarian cancer;liver cancer;colorectal cancer;melanoma;liver cancer;acute myeloid leukemia;liver cancer;gastric cancer;prostate cancer;sarcoma hsa-miR-380-5p TP53 -0.356387125389103 0.0163515117264043 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate -0.130032370502874 2.53621800466177e-09 NA NA NA hsa-miR-381-3p TP53 -0.192118086401438 0.203198554750071 0.346312114104146 1.42081328137217e-05 MirTarget -0.10958470195975 2.36383687034549e-07 NA NA NA hsa-miR-421 TP53 -0.171573235029879 0.0518112933651029 0.346312114104146 1.42081328137217e-05 miRanda -0.12756767272718 0.000455424352559313 NA NA NA hsa-miR-491-5p TP53 -0.749881113074983 8.22859263179194e-09 0.346312114104146 1.42081328137217e-05 MirTarget;miRanda -0.210461133541589 1.59624493209635e-19 23519249 Targeted site prediction indicated that both Bcl-XL and TP53 contain miR-491-5p recognizing sites in their 3' UTRs; Overexpression of miR-491-5p in the pancreatic cancer cell line SW1990 effectively inhibited both endogenous Bcl-XL and TP53 gene expressions pancreatic cancer hsa-miR-504-5p TP53 -0.510726779625117 6.12122269907368e-05 0.346312114104146 1.42081328137217e-05 miRNAWalker2_validate;MirTarget -0.175599590135581 1.78517568542536e-12 25015107 TFF1 activates p53 through down regulation of miR 504 in gastric cancer; Alternatively we found that the reconstitution of TFF1 down-regulates miR-504 a negative regulator of p53; Western blot analysis data demonstrated that miR-504 abrogates TFF1-induced p53 protein expression and activity; In conclusion the in vitro and in vivo data demonstrate for the first time a novel mechanism by which the tumor suppressor functions of TFF1 involve activation of p53 through down-regulation of miR-504 gastric cancer