miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-105-5p AKT2 -0.567459149851677 8.20858944634795e-06 0.139361896216647 0.0151763675439579 mirMAP -0.11517777162873 2.5456118337521e-14 NA NA NA hsa-miR-146b-5p AKT3 0.441078059667297 0.000237619929889385 -0.235109681312394 0.000861339724103604 miRNAWalker2_validate -0.14853390000962 1.54850741316524e-10 NA NA NA hsa-miR-15a-5p AKT3 0.142658985373611 0.0536219185009004 -0.235109681312394 0.000861339724103604 miRNAWalker2_validate;miRTarBase;miRNATAP -0.171093255137198 0.000104922528677221 NA NA NA hsa-miR-15b-5p AKT3 0.592863156692837 1.41971517354055e-10 -0.235109681312394 0.000861339724103604 miRNATAP -0.149023414077877 1.00397425898265e-06 NA NA NA hsa-miR-28-3p AKT3 0.139444423971018 0.0811187936164314 -0.235109681312394 0.000861339724103604 miRNATAP -0.281326919526608 6.94030005162363e-11 NA NA NA hsa-miR-320a AKT3 0.092135599636725 0.243028758989929 -0.235109681312394 0.000861339724103604 PITA;miRanda;miRNATAP -0.162091233103736 0.000150010109497495 NA NA NA hsa-miR-320c AKT3 0.343259124189966 0.000248338401291051 -0.235109681312394 0.000861339724103604 PITA;miRanda;miRNATAP -0.11345587888064 0.000121683825333423 NA NA NA hsa-miR-362-3p AKT3 0.032375035235532 0.736465332563774 -0.235109681312394 0.000861339724103604 miRanda -0.133145359057788 1.93504628679194e-06 NA NA NA hsa-miR-362-5p AKT3 -0.0730185557229279 0.425572997292224 -0.235109681312394 0.000861339724103604 PITA;TargetScan;miRNATAP -0.12269062278053 4.12753291036148e-05 NA NA NA hsa-miR-501-3p AKT3 0.0726267165568464 0.382729320534971 -0.235109681312394 0.000861339724103604 miRNATAP -0.230986821283872 3.52473505159126e-12 NA NA NA hsa-miR-502-3p AKT3 0.0276791089364088 0.697605011368848 -0.235109681312394 0.000861339724103604 miRNATAP -0.217874003496912 1.14360007951059e-08 NA NA NA hsa-miR-93-5p AKT3 0.139766237971122 0.101057320076629 -0.235109681312394 0.000861339724103604 miRNATAP -0.208262975522215 1.91431764461584e-05 NA NA NA hsa-miR-125a-3p CASP9 0.183834985432376 0.106230647107917 -0.190390818122219 0.00860629060432951 miRanda -0.10922116203645 1.51947097140883e-05 NA NA NA hsa-miR-126-5p CASP9 0.177332403948664 0.0711675116243123 -0.190390818122219 0.00860629060432951 MirTarget -0.260533886267505 9.08731800375383e-19 NA NA NA hsa-miR-133a-3p CASP9 -0.335058908302964 0.0180402783121034 -0.190390818122219 0.00860629060432951 miRNAWalker2_validate;miRTarBase -0.126150713979561 1.5336707780324e-10 NA NA NA hsa-miR-140-5p CASP9 0.065063507103468 0.380452509211773 -0.190390818122219 0.00860629060432951 miRanda -0.198208812177151 1.81618262797927e-06 NA NA NA hsa-miR-15a-5p CASP9 0.142658985373611 0.0536219185009004 -0.190390818122219 0.00860629060432951 mirMAP -0.235687914842974 3.68148704667338e-07 NA NA NA hsa-miR-15b-5p CASP9 0.592863156692837 1.41971517354055e-10 -0.190390818122219 0.00860629060432951 mirMAP -0.194862381425862 1.11164072592137e-09 NA NA NA hsa-miR-16-5p CASP9 0.246024668671282 0.00346042804503716 -0.190390818122219 0.00860629060432951 mirMAP -0.203519004171527 3.05123518551225e-07 NA NA NA hsa-miR-193b-3p CASP9 0.0766333116224072 0.324723824453143 -0.190390818122219 0.00860629060432951 miRNAWalker2_validate -0.287691751817182 2.55461285152645e-14 NA NA NA hsa-miR-199a-3p CASP9 0.41226331871076 0.000497136154474528 -0.190390818122219 0.00860629060432951 mirMAP -0.203767948496481 7.25854614561419e-18 23319430 The techniques used were the MTT assay flow cytometry real-time PCR to assess miR-199a expression as also caspase-8 and caspase-9 activity in HepG2 cells treated with Propofol liver cancer hsa-miR-199b-3p CASP9 0.411848361704393 0.000517815011892379 -0.190390818122219 0.00860629060432951 mirMAP -0.202937922848071 8.40130462827375e-18 NA NA NA hsa-miR-342-5p CASP9 0.0383784541944436 0.544128449296127 -0.190390818122219 0.00860629060432951 MirTarget -0.172780651339529 0.000183272409998028 NA NA NA hsa-miR-424-5p CASP9 0.25140374049676 0.00709934939774983 -0.190390818122219 0.00860629060432951 mirMAP -0.121649518123937 0.000136932797700071 NA NA NA hsa-miR-450b-5p CASP9 0.270544879013992 0.00801537838499562 -0.190390818122219 0.00860629060432951 mirMAP -0.107405523905285 0.000148848993244956 NA NA NA hsa-miR-495-3p CASP9 -0.421982588962504 0.00504424038526901 -0.190390818122219 0.00860629060432951 mirMAP -0.112698137537794 1.81004622187323e-09 NA NA NA hsa-miR-548b-3p CASP9 0.340474544210108 0.00224491592019745 -0.190390818122219 0.00860629060432951 MirTarget -0.12601735851912 9.6237618924232e-07 NA NA NA hsa-miR-590-3p CASP9 0.312951515438396 0.000480455423843996 -0.190390818122219 0.00860629060432951 miRanda -0.109539366255286 0.000563304082980271 NA NA NA hsa-let-7b-5p HRAS 0.036218385218298 0.719557004564478 -0.0696529935819452 0.235865730348535 miRTarBase -0.105421362575589 0.000967581673758039 20607356;20881268;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;On the basis of these data we suggest that the downregulation of let-7b and let-7e targeting K-ras and the upregulation of miR-17* a CRC marker could be considered as candidate molecular markers of cetuximab resistance;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;drug resistance;;;progression glioblastoma;colorectal cancer;lung cancer;lung cancer;pancreatic cancer hsa-miR-181d-5p HRAS -0.0746131973223108 0.331281641674538 -0.0696529935819452 0.235865730348535 miRNAWalker2_validate;miRTarBase -0.133860130747548 5.02157599075857e-05 NA NA NA hsa-miR-577 HSPB1 -0.382068371859275 0.0145513192729119 0.526807327159886 7.72626999801002e-07 PITA -0.126253280760655 1.43369150075721e-05 NA NA NA hsa-miR-149-5p KDR -0.0535821592029952 0.657713892012548 0.270090175645727 0.00117141833672443 miRNATAP -0.139518259926423 2.03714324877248e-06 NA NA NA hsa-miR-3065-3p KDR -0.261348288537884 0.0343753235107924 0.270090175645727 0.00117141833672443 miRNATAP -0.177937727091403 1.20271139230931e-09 NA NA NA hsa-let-7a-3p KRAS 0.0530563276543763 0.370749834463566 -0.0976184278638819 0.0473238165779176 mirMAP;miRNATAP -0.163441029301714 2.66738583745088e-07 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-miR-30b-5p KRAS -0.0858101016322106 0.263243418521854 -0.0976184278638819 0.0473238165779176 mirMAP;miRNATAP -0.131312331179891 6.91058885171462e-07 NA NA NA hsa-let-7b-5p MAP2K2 0.036218385218298 0.719557004564478 0.0338816015099894 0.511977780289519 miRNAWalker2_validate -0.156288464298574 5.22052349984698e-12 NA NA NA hsa-let-7a-3p MAPK1 0.0530563276543763 0.370749834463566 -0.213353498035088 0.000389157534366882 mirMAP -0.101943093753909 0.00192343923976389 NA NA NA hsa-miR-15b-5p MAPK1 0.592863156692837 1.41971517354055e-10 -0.213353498035088 0.000389157534366882 miRNAWalker2_validate -0.146191950491781 3.61739654178022e-14 NA NA NA hsa-miR-17-5p MAPK1 0.0975751369167082 0.20621110214601 -0.213353498035088 0.000389157534366882 TargetScan -0.110084866776271 7.91694183424384e-05 NA NA NA hsa-miR-19a-3p MAPK1 0.0466707843731911 0.576818938277755 -0.213353498035088 0.000389157534366882 mirMAP -0.128018489349713 2.73892272625697e-09 NA NA NA hsa-miR-19b-3p MAPK1 -0.0138427450847924 0.856506310673067 -0.213353498035088 0.000389157534366882 mirMAP -0.176138435921289 5.03823623056019e-12 NA NA NA hsa-miR-320a MAPK1 0.092135599636725 0.243028758989929 -0.213353498035088 0.000389157534366882 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.152520075612356 2.3025642938828e-08 NA NA NA hsa-miR-454-3p MAPK1 0.177318549827649 0.0120865170334418 -0.213353498035088 0.000389157534366882 mirMAP -0.118488517070993 3.52065356643667e-06 NA NA NA hsa-miR-500a-3p MAPK1 0.0479457078972052 0.49420307623914 -0.213353498035088 0.000389157534366882 mirMAP -0.108343486711378 0.000199332911985672 NA NA NA hsa-miR-125a-5p MAPK12 -0.0833349424517387 0.325440200253607 -0.184333888101058 0.00516853982989052 miRNATAP -0.246707780375399 3.61083114361096e-11 NA NA NA hsa-miR-320b MAPK3 0.283477746304177 0.0005953763020907 -0.216288134544279 3.58169845564714e-05 miRNAWalker2_validate -0.103417988183093 3.03681040754152e-07 NA NA NA hsa-miR-542-3p MAPK3 0.0835995677900829 0.403838744494071 -0.216288134544279 3.58169845564714e-05 miRanda -0.133723416342879 2.41125253328141e-13 NA NA NA hsa-miR-124-3p MAPKAPK2 -0.506026514549291 0.0078056370358648 0.197884443595911 0.000243637469653919 miRNAWalker2_validate -0.104193214862002 1.11355518201979e-30 NA NA NA hsa-miR-129-2-3p MAPKAPK2 -0.6175132197013 0.000561573620904867 0.197884443595911 0.000243637469653919 mirMAP -0.104836723140721 9.64833201965142e-28 NA NA NA hsa-miR-485-3p MAPKAPK2 -0.530677478972593 0.00148549219838911 0.197884443595911 0.000243637469653919 MirTarget;PITA;miRNATAP -0.100951350110281 2.35175125442569e-22 NA NA NA hsa-miR-9-5p MAPKAPK2 -0.125377971246422 0.269896477802284 0.197884443595911 0.000243637469653919 miRNATAP -0.247223486381394 3.27193806699658e-10 NA NA NA hsa-miR-128-3p MAPKAPK3 -0.781932174412672 7.1812756321342e-10 0.0666408822263467 0.280567270992267 MirTarget -0.131034188481023 8.75519753669743e-11 NA NA NA hsa-miR-137 NFATC1 -0.924849266740909 1.546832202049e-06 0.204786711368586 0.0511949488637229 miRanda;miRNATAP -0.107798622041435 3.4819034015331e-06 NA NA NA hsa-miR-139-5p NFATC1 -0.647754756897633 2.15378307237163e-06 0.204786711368586 0.0511949488637229 miRanda -0.256587875136984 2.02892529769674e-14 NA NA NA hsa-miR-133a-3p NFATC2 -0.335058908302964 0.0180402783121034 0.373288538309896 0.0141934989113001 MirTarget -0.126883299764603 0.00682609791314944 NA NA NA hsa-miR-137 NFATC2 -0.924849266740909 1.546832202049e-06 0.373288538309896 0.0141934989113001 MirTarget -0.159446756645839 2.79388179466433e-06 NA NA NA hsa-miR-19a-3p NFATC2 0.0466707843731911 0.576818938277755 0.373288538309896 0.0141934989113001 mirMAP -0.236809111690551 0.00474447094856751 NA NA NA hsa-miR-19b-3p NFATC2 -0.0138427450847924 0.856506310673067 0.373288538309896 0.0141934989113001 mirMAP -0.335169271204236 0.000783248779037379 NA NA NA hsa-miR-767-3p NFATC2 -0.429854368420513 0.000821445291167688 0.373288538309896 0.0141934989113001 mirMAP -0.151337879902996 0.0044563221543633 NA NA NA hsa-miR-9-5p NFATC2 -0.125377971246422 0.269896477802284 0.373288538309896 0.0141934989113001 MirTarget -1.15506700903417 6.16080043646465e-16 NA NA NA hsa-miR-9-5p NFATC3 -0.125377971246422 0.269896477802284 0.243130574740432 4.77137503381453e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.264692712043712 4.40776113604208e-13 NA NA NA hsa-miR-105-5p NFATC4 -0.567459149851677 8.20858944634795e-06 -0.081124592384517 0.381792074940761 mirMAP -0.233035161096435 4.65846890944727e-14 NA NA NA hsa-miR-181a-2-3p NFATC4 -0.0630409614874416 0.473088318215936 -0.081124592384517 0.381792074940761 mirMAP -0.280233830341353 9.31458848849117e-06 NA NA NA hsa-miR-3607-3p NFATC4 -0.0118040987013632 0.907228689257085 -0.081124592384517 0.381792074940761 miRNATAP -0.166177847132163 2.36930087506819e-05 NA NA NA hsa-miR-29a-3p NRAS -0.224140851576083 0.0349516103550236 0.166825456686155 0.00198701675555357 miRNATAP -0.113429370178798 7.18564270439906e-07 NA NA NA hsa-miR-29c-3p NRAS -0.372180390387259 0.00202634431973208 0.166825456686155 0.00198701675555357 miRNATAP -0.103186593831709 9.57910873311229e-10 NA NA NA hsa-miR-664a-3p NRAS 0.0413918462467198 0.611334357897022 0.166825456686155 0.00198701675555357 MirTarget -0.11306016643066 1.53334474091839e-06 NA NA NA hsa-miR-146b-5p PIK3CA 0.441078059667297 0.000237619929889385 0.037489443318349 0.579330715365297 mirMAP -0.131612247931155 2.37773318343185e-08 NA NA NA hsa-miR-339-5p PIK3CA 0.273253751377152 0.0185300170790638 0.037489443318349 0.579330715365297 miRanda -0.104034425659594 8.90794530378182e-06 NA NA NA hsa-miR-361-5p PIK3CA 0.0107519600643302 0.882230614095565 0.037489443318349 0.579330715365297 mirMAP -0.180837597518142 0.000106487510577531 NA NA NA hsa-miR-501-5p PIK3CA 0.0878951859817452 0.309663377222443 0.037489443318349 0.579330715365297 mirMAP -0.121849868853655 0.000118457183740553 NA NA NA hsa-miR-130b-3p PIK3CB 0.503911467685709 9.46590588950823e-08 -0.219948641615068 6.65962821954743e-06 miRNATAP -0.103286697323809 1.47078743054601e-08 NA NA NA hsa-miR-19a-3p PIK3CB 0.0466707843731911 0.576818938277755 -0.219948641615068 6.65962821954743e-06 miRNATAP -0.106776286308973 5.5364329421429e-07 NA NA NA hsa-miR-19b-3p PIK3CB -0.0138427450847924 0.856506310673067 -0.219948641615068 6.65962821954743e-06 miRNATAP -0.144620281397534 1.13083007810642e-08 NA NA NA hsa-miR-25-3p PIK3CB 0.316649850160985 0.000777982468387578 -0.219948641615068 6.65962821954743e-06 miRNATAP -0.107740273525281 5.28619562870356e-06 NA NA NA hsa-miR-126-3p PIK3CG 0.283844173647452 0.0045313860754322 0.426342297358177 0.000910429107358105 miRTarBase -0.253640716789511 9.06991114742445e-05 NA NA NA hsa-miR-137 PIK3CG -0.924849266740909 1.546832202049e-06 0.426342297358177 0.000910429107358105 miRanda -0.150716294097788 1.51412490486832e-07 NA NA NA hsa-miR-139-5p PIK3CG -0.647754756897633 2.15378307237163e-06 0.426342297358177 0.000910429107358105 miRanda -0.231442980598987 3.92120693342636e-08 NA NA NA hsa-miR-103a-3p PIK3R1 -0.147443193527362 0.128400914654149 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.281302889120328 4.63842851180526e-09 NA NA NA hsa-miR-106a-5p PIK3R1 0.110074064773897 0.13045815990621 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.141577511066847 0.000568718663709082 NA NA NA hsa-miR-106b-5p PIK3R1 0.167096183547615 0.0497544396383451 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.114620357579885 0.00229922204074265 NA NA NA hsa-miR-1301-3p PIK3R1 -0.105695714210758 0.152249184194132 -0.259275224308753 0.00106935451973482 MirTarget -0.230097168026832 5.13675721710063e-09 NA NA NA hsa-miR-150-5p PIK3R1 0.0645271721519611 0.513295658828718 -0.259275224308753 0.00106935451973482 MirTarget -0.105207403299517 0.000393418533820088 NA NA NA hsa-miR-15a-5p PIK3R1 0.142658985373611 0.0536219185009004 -0.259275224308753 0.00106935451973482 MirTarget -0.230258286136212 5.21596791619245e-07 NA NA NA hsa-miR-15b-5p PIK3R1 0.592863156692837 1.41971517354055e-10 -0.259275224308753 0.00106935451973482 MirTarget -0.235643490684548 5.7801231863435e-14 NA NA NA hsa-miR-16-2-3p PIK3R1 0.468816222075619 7.04377763166292e-05 -0.259275224308753 0.00106935451973482 MirTarget -0.139286207343494 2.58317956279833e-09 NA NA NA hsa-miR-16-5p PIK3R1 0.246024668671282 0.00346042804503716 -0.259275224308753 0.00106935451973482 MirTarget -0.121551450392141 0.00217223263389569 NA NA NA hsa-miR-185-5p PIK3R1 -0.0767432095218297 0.404113540276816 -0.259275224308753 0.00106935451973482 miRNATAP -0.168972197052794 1.52142067802957e-07 NA NA NA hsa-miR-186-5p PIK3R1 0.0606381894130505 0.514217717592464 -0.259275224308753 0.00106935451973482 mirMAP -0.273384834286173 4.58184035796298e-17 NA NA NA hsa-miR-199a-3p PIK3R1 0.41226331871076 0.000497136154474528 -0.259275224308753 0.00106935451973482 miRNATAP -0.150441413618647 2.58272678316472e-10 NA NA NA hsa-miR-199a-5p PIK3R1 0.174889610847968 0.0900027418912454 -0.259275224308753 0.00106935451973482 miRanda -0.169409376623758 6.00323276983558e-10 NA NA NA hsa-miR-199b-3p PIK3R1 0.411848361704393 0.000517815011892379 -0.259275224308753 0.00106935451973482 miRNATAP -0.149610269102807 2.9670988718931e-10 NA NA NA hsa-miR-199b-5p PIK3R1 0.436298593972862 0.00200225454383871 -0.259275224308753 0.00106935451973482 miRanda -0.158988773915679 1.96615064731078e-16 NA NA NA hsa-miR-200b-3p PIK3R1 0.245768526504511 0.0580744465744737 -0.259275224308753 0.00106935451973482 mirMAP -0.203398688722103 1.6080278648636e-21 NA NA NA hsa-miR-200c-3p PIK3R1 0.413752622631695 8.6936333715621e-06 -0.259275224308753 0.00106935451973482 mirMAP -0.313372851003899 1.11853298374691e-27 NA NA NA hsa-miR-21-5p PIK3R1 1.0504925175311 2.58081295984106e-11 -0.259275224308753 0.00106935451973482 miRNAWalker2_validate;MirTarget;miRNATAP -0.192193122796698 2.35557430088274e-23 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 0.0437233965539527 0.639996108995995 -0.259275224308753 0.00106935451973482 mirMAP -0.26421716056902 5.35024336821731e-19 NA NA NA hsa-miR-221-3p PIK3R1 -0.0109507285071775 0.936440693394519 -0.259275224308753 0.00106935451973482 MirTarget -0.125242954911868 1.02528886125279e-09 NA NA NA hsa-miR-222-3p PIK3R1 0.107117065575197 0.423818119725697 -0.259275224308753 0.00106935451973482 MirTarget -0.132930686168698 1.29543187744781e-10 NA NA NA hsa-miR-28-5p PIK3R1 0.104003572105781 0.153594705579534 -0.259275224308753 0.00106935451973482 miRanda -0.263804174247158 1.47407900801522e-10 NA NA NA hsa-miR-29b-3p PIK3R1 -0.178522712044497 0.0856106432165465 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.145678229090259 1.47483484512088e-06 NA NA NA hsa-miR-320a PIK3R1 0.092135599636725 0.243028758989929 -0.259275224308753 0.00106935451973482 miRNATAP -0.135112165926423 0.00256497204146449 NA NA NA hsa-miR-320c PIK3R1 0.343259124189966 0.000248338401291051 -0.259275224308753 0.00106935451973482 miRNATAP -0.100797336995439 0.0011155444118643 NA NA NA hsa-miR-361-5p PIK3R1 0.0107519600643302 0.882230614095565 -0.259275224308753 0.00106935451973482 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.28102979614435 4.07903189307061e-09 NA NA NA hsa-miR-374a-3p PIK3R1 0.176226170437625 0.0343958848425446 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.321250741910251 7.52372972851822e-15 NA NA NA hsa-miR-424-5p PIK3R1 0.25140374049676 0.00709934939774983 -0.259275224308753 0.00106935451973482 MirTarget -0.179589895147171 9.52256678975884e-09 NA NA NA hsa-miR-455-3p PIK3R1 0.512701816402104 0.000459755983280155 -0.259275224308753 0.00106935451973482 MirTarget;PITA;miRNATAP -0.161697245880861 9.23450362337655e-18 NA NA NA hsa-miR-532-3p PIK3R1 0.150624483952741 0.0599635132177191 -0.259275224308753 0.00106935451973482 MirTarget -0.152797062588971 2.75979429090484e-05 NA NA NA hsa-miR-542-3p PIK3R1 0.0835995677900829 0.403838744494071 -0.259275224308753 0.00106935451973482 MirTarget;PITA;miRanda -0.126538995109648 4.83333922747737e-05 NA NA NA hsa-miR-548b-3p PIK3R1 0.340474544210108 0.00224491592019745 -0.259275224308753 0.00106935451973482 mirMAP -0.215757322792441 3.83990685247808e-18 NA NA NA hsa-miR-589-3p PIK3R1 0.00739371736361305 0.927768051649329 -0.259275224308753 0.00106935451973482 mirMAP -0.128475712773886 0.000234342022369328 NA NA NA hsa-miR-590-3p PIK3R1 0.312951515438396 0.000480455423843996 -0.259275224308753 0.00106935451973482 miRanda;mirMAP -0.281948259643294 1.55243456524174e-20 NA NA NA hsa-miR-590-5p PIK3R1 0.16946027035949 0.0386004382081678 -0.259275224308753 0.00106935451973482 MirTarget;PITA;miRanda;miRNATAP -0.237039982006307 4.44595475697952e-12 NA NA NA hsa-miR-93-5p PIK3R1 0.139766237971122 0.101057320076629 -0.259275224308753 0.00106935451973482 MirTarget;miRNATAP -0.261542441732551 2.52352152477154e-07 NA NA NA hsa-miR-125a-3p PIK3R2 0.183834985432376 0.106230647107917 0.0588428389717066 0.330993461191286 miRanda -0.129596879826368 7.29774749644301e-14 NA NA NA hsa-miR-135a-5p PIK3R2 -0.122734612943241 0.196985964641886 0.0588428389717066 0.330993461191286 MirTarget;miRNATAP -0.131986778854444 6.81341317924018e-10 NA NA NA hsa-miR-28-5p PIK3R2 0.104003572105781 0.153594705579534 0.0588428389717066 0.330993461191286 miRanda -0.220439409614541 1.97006000122873e-14 NA NA NA hsa-miR-30a-5p PIK3R2 -0.062942936611238 0.513851954700252 0.0588428389717066 0.330993461191286 miRNATAP -0.422270293356803 9.55851299393926e-41 NA NA NA hsa-miR-30b-5p PIK3R2 -0.0858101016322106 0.263243418521854 0.0588428389717066 0.330993461191286 miRNATAP -0.124149959343624 7.09161751121272e-05 NA NA NA hsa-miR-30c-5p PIK3R2 -0.0469114469943097 0.565934557464627 0.0588428389717066 0.330993461191286 miRNAWalker2_validate;miRNATAP -0.240340425585456 4.99963373312426e-15 NA NA NA hsa-miR-30d-5p PIK3R2 -0.0607010868720046 0.471410043548794 0.0588428389717066 0.330993461191286 miRNATAP -0.157898559984916 9.76384983421278e-06 NA NA NA hsa-miR-30e-5p PIK3R2 0.0764521828640934 0.41904991629622 0.0588428389717066 0.330993461191286 miRNATAP -0.28288573453624 2.98060149038092e-23 NA NA NA hsa-miR-331-3p PIK3R2 0.0126984726684189 0.905175053956974 0.0588428389717066 0.330993461191286 MirTarget -0.109375813751675 5.11486213404741e-09 NA NA NA hsa-miR-339-5p PIK3R2 0.273253751377152 0.0185300170790638 0.0588428389717066 0.330993461191286 miRanda -0.141580109769359 1.93632849649246e-17 NA NA NA hsa-miR-34a-5p PIK3R2 0.143472919835524 0.211283228567057 0.0588428389717066 0.330993461191286 MirTarget -0.127777793508925 2.24958566486742e-13 NA NA NA hsa-miR-9-3p PIK3R3 -0.184945845984695 0.0290051908009009 0.266207970572364 5.77735138484935e-05 mirMAP -0.147414732691119 0.000303043365501486 NA NA NA hsa-miR-9-5p PIK3R3 -0.125377971246422 0.269896477802284 0.266207970572364 5.77735138484935e-05 miRNATAP -0.234645741849474 2.452186835562e-05 NA NA NA hsa-miR-106b-5p PLA2G12A 0.167096183547615 0.0497544396383451 -0.181962072480256 2.70460580179857e-05 mirMAP -0.123794031417231 8.40767531912829e-12 NA NA NA hsa-miR-93-5p PLA2G12A 0.139766237971122 0.101057320076629 -0.181962072480256 2.70460580179857e-05 mirMAP -0.134716211565272 5.93753764091159e-08 NA NA NA hsa-miR-491-5p PLA2G2A -0.749881113074983 8.22859263179194e-09 1.29188933567535 4.98156559625774e-07 miRanda -0.225010501106316 0.00842290234172622 NA NA NA hsa-miR-139-5p PLA2G4A -0.647754756897633 2.15378307237163e-06 0.459553101816434 3.96979969592525e-06 miRanda -0.196719913317323 1.19655643220759e-09 NA NA NA hsa-miR-2355-3p PLA2G6 0.186207523505296 0.0525918026993012 -0.329810877626427 6.39462398247452e-09 MirTarget -0.136794319081761 8.98869883320535e-10 NA NA NA hsa-miR-30a-3p PLA2G6 0.0655410309550977 0.509541256241954 -0.329810877626427 6.39462398247452e-09 miRNATAP -0.179375158849384 2.09226484033404e-10 NA NA NA hsa-miR-30d-3p PLA2G6 0.0854049347792898 0.20691254801121 -0.329810877626427 6.39462398247452e-09 miRNATAP -0.157387082946513 1.14186003565846e-06 NA NA NA hsa-miR-324-5p PLA2G6 0.0183370482495953 0.842996782677271 -0.329810877626427 6.39462398247452e-09 miRanda -0.112311121172656 2.84645215254445e-06 NA NA NA hsa-miR-106b-5p PPP3CA 0.167096183547615 0.0497544396383451 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.156975600850481 8.08375589469546e-06 NA NA NA hsa-miR-17-5p PPP3CA 0.0975751369167082 0.20621110214601 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.156864057675735 0.000234156174021412 NA NA NA hsa-miR-20a-5p PPP3CA -0.0115865752288853 0.887069448776018 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.11299242225162 0.0039148602825986 NA NA NA hsa-miR-21-5p PPP3CA 1.0504925175311 2.58081295984106e-11 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.130424810796755 2.20070954535807e-12 NA NA NA hsa-miR-320a PPP3CA 0.092135599636725 0.243028758989929 -0.373235846566351 7.56900657293056e-08 miRanda -0.211827782030443 4.01920568101511e-07 NA NA NA hsa-miR-320b PPP3CA 0.283477746304177 0.0005953763020907 -0.373235846566351 7.56900657293056e-08 miRanda -0.144192030306541 6.21193412642773e-06 NA NA NA hsa-miR-320c PPP3CA 0.343259124189966 0.000248338401291051 -0.373235846566351 7.56900657293056e-08 miRanda -0.159502579873982 3.05354814536541e-08 NA NA NA hsa-miR-450b-5p PPP3CA 0.270544879013992 0.00801537838499562 -0.373235846566351 7.56900657293056e-08 PITA;mirMAP;miRNATAP -0.158857807775905 1.0971728867913e-09 NA NA NA hsa-miR-93-3p PPP3CA 0.0778767956494004 0.272224943247293 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.103322549875116 0.00846397616128606 NA NA NA hsa-miR-93-5p PPP3CA 0.139766237971122 0.101057320076629 -0.373235846566351 7.56900657293056e-08 miRNATAP -0.294073353489622 5.63338473261847e-10 NA NA NA hsa-miR-15a-5p PPP3CB 0.142658985373611 0.0536219185009004 -0.433160664971454 7.64786199353402e-10 miRNATAP -0.154879727290926 0.000565344774724231 NA NA NA hsa-miR-15b-5p PPP3CB 0.592863156692837 1.41971517354055e-10 -0.433160664971454 7.64786199353402e-10 miRNATAP -0.237305735014458 6.56456884638479e-15 NA NA NA hsa-miR-30a-5p PPP3CB -0.062942936611238 0.513851954700252 -0.433160664971454 7.64786199353402e-10 miRNATAP -0.216347543291675 3.88335269674995e-06 NA NA NA hsa-miR-320a PPP3CB 0.092135599636725 0.243028758989929 -0.433160664971454 7.64786199353402e-10 miRanda -0.283610796821456 3.73775473194107e-11 NA NA NA hsa-miR-320b PPP3CB 0.283477746304177 0.0005953763020907 -0.433160664971454 7.64786199353402e-10 miRanda -0.214071216687752 5.61901615376464e-11 NA NA NA hsa-miR-320c PPP3CB 0.343259124189966 0.000248338401291051 -0.433160664971454 7.64786199353402e-10 miRanda -0.241503669878515 1.61057546698162e-16 NA NA NA hsa-miR-339-5p PPP3CB 0.273253751377152 0.0185300170790638 -0.433160664971454 7.64786199353402e-10 miRanda -0.14695495240965 2.98975197156432e-10 NA NA NA hsa-miR-424-5p PPP3CB 0.25140374049676 0.00709934939774983 -0.433160664971454 7.64786199353402e-10 miRNATAP -0.174803267163998 9.35958492728842e-09 NA NA NA hsa-miR-450b-5p PPP3CB 0.270544879013992 0.00801537838499562 -0.433160664971454 7.64786199353402e-10 MirTarget;PITA;miRNATAP -0.145409462742278 7.85383237188849e-08 NA NA NA hsa-miR-452-5p PPP3CB 0.599327068454211 1.02031931068531e-05 -0.433160664971454 7.64786199353402e-10 MirTarget;miRNATAP -0.100917826632377 3.76376326737129e-07 NA NA NA hsa-miR-501-5p PPP3CB 0.0878951859817452 0.309663377222443 -0.433160664971454 7.64786199353402e-10 PITA;miRNATAP -0.110974250509852 0.000497821238894801 NA NA NA hsa-miR-590-3p PPP3CB 0.312951515438396 0.000480455423843996 -0.433160664971454 7.64786199353402e-10 miRanda -0.13889306492083 5.08331239857392e-06 NA NA NA hsa-miR-500a-3p PPP3CC 0.0479457078972052 0.49420307623914 -0.0407919825674279 0.323390220477665 MirTarget;miRNATAP -0.107532400267747 7.33877743778064e-06 NA NA NA hsa-miR-27a-3p PPP3R1 0.303760032895792 0.00457375391189806 -0.284481378057962 3.41822765696265e-05 miRNATAP -0.102375961650782 9.77727749562009e-05 NA NA NA hsa-miR-320a PPP3R1 0.092135599636725 0.243028758989929 -0.284481378057962 3.41822765696265e-05 PITA;miRanda -0.228132769092911 2.62987783565586e-08 NA NA NA hsa-miR-320b PPP3R1 0.283477746304177 0.0005953763020907 -0.284481378057962 3.41822765696265e-05 PITA;miRanda -0.139121452927635 9.32245529079262e-06 NA NA NA hsa-miR-320c PPP3R1 0.343259124189966 0.000248338401291051 -0.284481378057962 3.41822765696265e-05 PITA;miRanda -0.155051607654631 4.4227147992575e-08 NA NA NA hsa-miR-93-5p PPP3R1 0.139766237971122 0.101057320076629 -0.284481378057962 3.41822765696265e-05 MirTarget;miRNATAP -0.159907992777141 0.000711555619167879 NA NA NA hsa-miR-146b-5p PRKCA 0.441078059667297 0.000237619929889385 -0.289954367502515 3.07027667899011e-05 mirMAP -0.14319708794989 9.06517098676715e-13 NA NA NA hsa-miR-186-5p PRKCA 0.0606381894130505 0.514217717592464 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.150359410939945 4.84077626913968e-08 NA NA NA hsa-miR-1976 PRKCA 0.127074435034705 0.277235601775457 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.108813705938178 3.46283535790712e-08 NA NA NA hsa-miR-200c-3p PRKCA 0.413752622631695 8.6936333715621e-06 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.178242109766722 4.41123343449352e-13 NA NA NA hsa-miR-22-5p PRKCA 0.0437233965539527 0.639996108995995 -0.289954367502515 3.07027667899011e-05 mirMAP -0.109722618118012 1.49794234596401e-05 NA NA NA hsa-miR-24-2-5p PRKCA 0.285455874963858 0.00610163594056254 -0.289954367502515 3.07027667899011e-05 miRNAWalker2_validate -0.126181943667759 1.61489847928406e-08 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-27b-5p PRKCA 0.224282840351546 0.00630787296051719 -0.289954367502515 3.07027667899011e-05 mirMAP -0.177695243384062 3.0717917979023e-10 NA NA NA hsa-miR-339-5p PRKCA 0.273253751377152 0.0185300170790638 -0.289954367502515 3.07027667899011e-05 mirMAP -0.144247762214447 3.06350803308541e-13 NA NA NA hsa-miR-374a-3p PRKCA 0.176226170437625 0.0343958848425446 -0.289954367502515 3.07027667899011e-05 mirMAP -0.183155883331884 1.46022453353189e-07 NA NA NA hsa-miR-452-5p PRKCA 0.599327068454211 1.02031931068531e-05 -0.289954367502515 3.07027667899011e-05 mirMAP -0.107144316873697 1.95734554580544e-10 NA NA NA hsa-miR-500a-5p PRKCA 0.0634452729978863 0.396072382601677 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.184254955997398 3.38268451218896e-09 NA NA NA hsa-miR-501-5p PRKCA 0.0878951859817452 0.309663377222443 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.110873198819 4.40374990873549e-05 NA NA NA hsa-miR-505-3p PRKCA 0.115486008167472 0.109833720698312 -0.289954367502515 3.07027667899011e-05 miRNAWalker2_validate -0.183149886354061 7.20630466764891e-08 NA NA NA hsa-miR-505-5p PRKCA 0.0973008785018434 0.183209581426791 -0.289954367502515 3.07027667899011e-05 mirMAP -0.102672793703942 0.00160299774148607 NA NA NA hsa-miR-548b-3p PRKCA 0.340474544210108 0.00224491592019745 -0.289954367502515 3.07027667899011e-05 PITA;miRNATAP -0.107410539931332 3.63814329290144e-07 NA NA NA hsa-miR-550a-3p PRKCA 0.311518294008363 0.0015285640451888 -0.289954367502515 3.07027667899011e-05 miRNATAP -0.135787662750574 7.76840887594873e-09 NA NA NA hsa-miR-590-3p PRKCA 0.312951515438396 0.000480455423843996 -0.289954367502515 3.07027667899011e-05 PITA;miRanda;mirMAP;miRNATAP -0.152536946782924 3.436144371863e-09 NA NA NA hsa-miR-93-3p PRKCA 0.0778767956494004 0.272224943247293 -0.289954367502515 3.07027667899011e-05 mirMAP -0.146551656012825 2.11995627214635e-05 NA NA NA hsa-miR-155-5p PRKCB 0.969837380981085 5.86551495710056e-15 -0.682239380816002 3.52750339218814e-07 mirMAP -0.235836634520576 1.53174038755186e-07 NA NA NA hsa-miR-195-3p PRKCB 0.100105455903079 0.133362389112338 -0.682239380816002 3.52750339218814e-07 mirMAP -0.359971667645682 5.30224329291627e-05 NA NA NA hsa-miR-200c-3p PRKCB 0.413752622631695 8.6936333715621e-06 -0.682239380816002 3.52750339218814e-07 MirTarget;miRNATAP -0.208521490107408 0.000752162039048593 NA NA NA hsa-miR-23a-3p PRKCB 0.334693010651106 0.00144448147063433 -0.682239380816002 3.52750339218814e-07 mirMAP -0.27145045765466 1.33239615330638e-05 NA NA NA hsa-miR-27a-3p PRKCB 0.303760032895792 0.00457375391189806 -0.682239380816002 3.52750339218814e-07 MirTarget;miRNATAP -0.215141700970757 0.000219945845412233 NA NA NA hsa-miR-450b-5p PRKCB 0.270544879013992 0.00801537838499562 -0.682239380816002 3.52750339218814e-07 miRNATAP -0.161638000758075 0.00497309309812017 NA NA NA hsa-miR-590-3p PRKCB 0.312951515438396 0.000480455423843996 -0.682239380816002 3.52750339218814e-07 mirMAP -0.223842383414072 0.000503630468502308 NA NA NA hsa-miR-320a PRKCG 0.092135599636725 0.243028758989929 -1.05900738460984 1.8225118256495e-06 MirTarget;miRanda -0.531753093228863 0.000615460761538157 NA NA NA hsa-miR-320b PRKCG 0.283477746304177 0.0005953763020907 -1.05900738460984 1.8225118256495e-06 MirTarget;miRanda -0.367797376788092 0.00188611730145367 NA NA NA hsa-miR-320c PRKCG 0.343259124189966 0.000248338401291051 -1.05900738460984 1.8225118256495e-06 MirTarget;miRanda -0.485123776133657 5.54850190547458e-06 NA NA NA hsa-miR-532-3p PRKCG 0.150624483952741 0.0599635132177191 -1.05900738460984 1.8225118256495e-06 miRNATAP -0.329482037092211 0.00954229687515554 NA NA NA hsa-miR-320a PTGS2 0.092135599636725 0.243028758989929 0.13607309997433 0.394541859374157 miRNAWalker2_validate -0.339446498210426 0.00217311502613754 NA NA NA hsa-miR-124-3p PXN -0.506026514549291 0.0078056370358648 0.188191555874261 0.000800159404794241 miRNAWalker2_validate -0.118740318622953 1.02798389850039e-38 NA NA NA hsa-miR-132-3p PXN -0.178379362833856 0.13335200877129 0.188191555874261 0.000800159404794241 MirTarget;miRNATAP -0.145649919070102 1.14678251681947e-19 26675712 Bioinformatics analysis indicated that the mechanism underlying the tumor suppressor role of miR-132 in CRC cells may play a role in tumor suppression by targeting paxillin colorectal cancer hsa-miR-137 PXN -0.924849266740909 1.546832202049e-06 0.188191555874261 0.000800159404794241 miRNAWalker2_validate;MirTarget;PITA;miRanda;miRNATAP -0.106669022660479 1.53831349696727e-32 23275153;24243432 Overexpression of paxillin induced by miR 137 suppression promotes tumor progression and metastasis in colorectal cancer; The deregulation of paxillin PXN has been involved in the progression and metastasis of different malignancies including colorectal cancer CRC miR-137 is frequently suppressed in CRC; PXN is predicted to be a direct target of miR-137 in CRC cells; On this basis we hypothesized that overexpression of PXN induced by suppression of miR-137 may promote tumor progression and metastasis and predicts poor prognosis; Higher level of PXN messenger RNA mRNA and lower level of miR-137 was observed in cancer tissues than adjacent non-cancerous tissues; High expression of PXN and low expression of miR-137 was associated with aggressive tumor phenotype and adverse prognosis; Moreover the expression of PXN was negatively correlated with miR-137 expression; A dual-luciferase reporter gene assay validated that PXN was a direct target of miR-137; The use of miR-137 mimics or inhibitor could decrease or increase PXN mRNA and protein levels in CRC cell lines; Knockdown of PXN or ectopic expression of miR-137 could markedly inhibit cell proliferation migration and invasion in vitro and repress tumor growth and metastasis in vivo; Taken together these results demonstrated that overexpression of PXN induced by suppression of miR-137 promotes tumor progression and metastasis and could serve as an independent prognostic indicator in CRC patients;miR 137 impairs the proliferative and migratory capacity of human non small cell lung cancer cells by targeting paxillin; Taken together our results showed that miR-137 acted as a tumor suppressor in NSCLC by targeting PXN and it may provide novel diagnostic and therapeutic options for human NSCLC clinical operation in future metastasis;progression;worse prognosis; colorectal cancer;lung squamous cell cancer hsa-miR-203a-3p PXN -0.393041310603753 0.0191851699904077 0.188191555874261 0.000800159404794241 MirTarget -0.113331548616425 4.74029421891229e-27 NA NA NA hsa-miR-342-5p PXN 0.0383784541944436 0.544128449296127 0.188191555874261 0.000800159404794241 PITA;miRNATAP -0.106074632309767 0.000444537538954009 NA NA NA hsa-miR-361-3p PXN -0.0798653643614555 0.271064714084553 0.188191555874261 0.000800159404794241 mirMAP -0.121983759683941 3.27750876515579e-05 NA NA NA hsa-miR-488-3p PXN -0.257955761012568 0.00280795162806256 0.188191555874261 0.000800159404794241 mirMAP -0.129293562998446 3.02526491500881e-09 NA NA NA hsa-miR-124-3p RAC2 -0.506026514549291 0.0078056370358648 0.543102090563642 6.32748728882766e-07 mirMAP -0.16328824721264 5.64768337601236e-11 NA NA NA hsa-miR-129-5p RAC2 -0.567133990117126 0.00116152215679936 0.543102090563642 6.32748728882766e-07 miRanda -0.163216019318866 3.88418743152648e-09 NA NA NA hsa-miR-491-5p RAC2 -0.749881113074983 8.22859263179194e-09 0.543102090563642 6.32748728882766e-07 miRanda -0.143477171929978 6.8541464600559e-05 NA NA NA hsa-miR-125a-5p RAC3 -0.0833349424517387 0.325440200253607 -0.0694477011024395 0.398923087359439 PITA -0.255720823416584 1.87026446294698e-07 NA NA NA hsa-miR-30c-2-3p RAC3 -0.18630560418806 0.0313113706136533 -0.0694477011024395 0.398923087359439 miRNAWalker2_validate -0.340394704089941 3.11880878701484e-16 NA NA NA hsa-miR-590-3p RAC3 0.312951515438396 0.000480455423843996 -0.0694477011024395 0.398923087359439 miRanda -0.139701651516001 0.000218392196649336 NA NA NA hsa-miR-671-5p RAC3 0.379677704170736 0.000129391032677459 -0.0694477011024395 0.398923087359439 miRNATAP -0.228245307641295 7.53346315814315e-12 NA NA NA hsa-miR-125a-5p RAF1 -0.0833349424517387 0.325440200253607 -0.00553586733389189 0.905894621254653 miRanda -0.122061217158812 1.14719678269113e-13 NA NA NA hsa-miR-146b-3p RAF1 0.283486177568242 0.0118918188864879 -0.00553586733389189 0.905894621254653 MirTarget;PITA;miRNATAP -0.122160060310276 3.66962239698306e-36 NA NA NA hsa-miR-23b-3p RAF1 0.0476610245860094 0.630277683372344 -0.00553586733389189 0.905894621254653 miRNAWalker2_validate -0.142246538184778 8.25666529544947e-31 NA NA NA hsa-miR-484 RAF1 -0.0190828819137732 0.802298900989652 -0.00553586733389189 0.905894621254653 MirTarget -0.126030948035335 1.89321721164606e-15 NA NA NA hsa-miR-186-5p SHC2 0.0606381894130505 0.514217717592464 -0.157093814295037 0.0281990595568535 miRNAWalker2_validate -0.308195942401308 6.25748897331572e-23 NA NA NA hsa-miR-26a-5p SHC2 0.033823776747294 0.726610414342369 -0.157093814295037 0.0281990595568535 miRNAWalker2_validate -0.217858705592343 1.34512454332448e-10 NA NA NA hsa-miR-16-5p SRC 0.246024668671282 0.00346042804503716 -0.106998733090689 0.0398060494377972 mirMAP -0.10465484437835 1.88169161043919e-05 NA NA NA hsa-miR-2355-5p SRC 0.00808596988211185 0.916165501155096 -0.106998733090689 0.0398060494377972 mirMAP -0.229748977488401 1.59637645166255e-23 NA NA NA hsa-miR-23b-3p SRC 0.0476610245860094 0.630277683372344 -0.106998733090689 0.0398060494377972 miRNAWalker2_validate;miRTarBase -0.148910423280263 1.35758188365807e-14 23074286 miR 23b represses proto oncogene Src kinase and functions as methylation silenced tumor suppressor with diagnostic and prognostic significance in prostate cancer; We showed that proto-oncogene Src kinase and Akt are direct targets of miR-23b; Depletion of Src by RNA interference conferred similar functional effects as that of miR-23b reconstitution; miR-23b expression caused a dramatic decrease in tumor growth in nude mice and attenuated Src expression in excised tumors compared with a control miR prostate cancer hsa-miR-34a-5p SRC 0.143472919835524 0.211283228567057 -0.106998733090689 0.0398060494377972 MirTarget -0.136937295010404 1.20072332109243e-19 25396727;26676753 Furthermore Src was identified as a target of miR-34a with miR-34a inhibiting SRC expression and consequently triggering the suppression of the SRC/Ras/ERK pathway;miR 34a Silences c SRC to Attenuate Tumor Growth in Triple Negative Breast Cancer; Furthermore restoration of miR-34a in cell lines representing these subtypes inhibited proliferation and invasion activated senescence and promoted sensitivity to dasatinib by targeting the proto-oncogene c-SRC; Moreover miR-34a administration significantly delayed tumor growth of subcutaneously and orthotopically implanted tumors in nude mice and was accompanied by c-SRC downregulation; Finally we found that miR-34a and SRC levels were inversely correlated in human tumor specimens ; breast cancer;breast cancer hsa-miR-361-3p SRC -0.0798653643614555 0.271064714084553 -0.106998733090689 0.0398060494377972 PITA;mirMAP -0.168747281250129 6.22672377749193e-10 NA NA NA hsa-miR-455-5p SRC 0.332224239762 0.0106491358056238 -0.106998733090689 0.0398060494377972 miRanda -0.113536546750571 2.99089247608439e-18 NA NA NA hsa-miR-101-3p VEGFA -0.132333931567244 0.241891922291381 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate -0.179012476724308 0.000221850261733319 NA NA NA hsa-miR-1224-5p VEGFA -0.53941068839383 0.00201058335769201 0.545202702414815 3.65580722751043e-08 MirTarget -0.12693052777853 1.1909229874546e-07 NA NA NA hsa-miR-129-5p VEGFA -0.567133990117126 0.00116152215679936 0.545202702414815 3.65580722751043e-08 miRanda -0.178350435603243 1.58281485759764e-13 NA NA NA hsa-miR-26b-3p VEGFA -0.0542537787460029 0.4802214385739 0.545202702414815 3.65580722751043e-08 MirTarget -0.151139595719221 0.00815352929658283 NA NA NA hsa-miR-29a-3p VEGFA -0.224140851576083 0.0349516103550236 0.545202702414815 3.65580722751043e-08 MirTarget -0.188400523607611 0.000280773283001581 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29b-2-5p VEGFA -0.26834261955727 0.00453760540520233 0.545202702414815 3.65580722751043e-08 MirTarget -0.238273224497899 1.35712590368669e-07 NA NA NA hsa-miR-29b-3p VEGFA -0.178522712044497 0.0856106432165465 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.174785884873336 0.000121514677714241 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-29c-3p VEGFA -0.372180390387259 0.00202634431973208 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate;MirTarget -0.163350888739243 2.07703033697715e-05 NA NA NA hsa-miR-330-3p VEGFA -0.427388106938151 0.00300489284414266 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate -0.14940180557451 2.38610841931945e-07 NA NA NA hsa-miR-342-3p VEGFA -0.125683829770877 0.105810751640137 0.545202702414815 3.65580722751043e-08 miRanda;miRNATAP -0.183375082823802 0.00268020639799555 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERα mRNA expression increased breast cancer hsa-miR-374b-5p VEGFA -0.210113949579608 0.0056866083818614 0.545202702414815 3.65580722751043e-08 MirTarget -0.259691752964477 3.6506936798186e-05 NA NA NA hsa-miR-383-5p VEGFA -0.850440167826561 1.6745326125383e-07 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.171548247272876 2.39831482676198e-11 NA NA NA hsa-miR-497-5p VEGFA -0.000783764887886562 0.991703566618871 0.545202702414815 3.65580722751043e-08 MirTarget -0.217975385158274 0.000295143152499975 26718330;26485685;26336827;26202364;27015364;25176450;26840372 Furthermore western blot assay confirmed that the overexpression of miR-497 reduced VEGF and HIF-1α protein levels; Moreover miR-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model which was probably caused by the downregulation of pro-angiogenic molecules such as VEGF and HIF-1α;Role of miR 497 in VEGF A mediated cancer cell growth and invasion in non small cell lung cancer; Here we showed that compared to other cancers NSCLC had a significant higher ratio of VEGF-A protein vs mRNA and significantly lower levels of miR-497 suggesting presence of a post-transcriptional control of VEGF-A in NSCLC different from other cancers; Compared with paired normal lung tissue NSCLC expressed lower levels of miR-497 and higher levels of VEGF-A; Moreover the levels of miR-497 and VEGF-A were inversely correlated in NSCLC specimen; Bioinformatics analyses showed that miR-497 bound to 3'-UTR of VEGF-A mRNA in NSCLC lines to inhibit its translation; Overexpression of miR-497 in NSCLC lines decreased VEGF-A protein while depletion of miR-497 in NSCLC lines increased VEGF-A protein; However modification of miR-497 levels in NSCLC lines did not alter VEGF-A mRNA levels;MiR 497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG 1; Subsequent investigations disclosed that miR-497 directly inhibited the 3'-untranslated regions UTRs of vascular endothelial growth factor A VEGFA and astrocyte elevated gene-1 AEG-1;The effects of ectopic miR-497 expression on the expression of VEGFA Akt and p-Akt were determined by western blot; Luciferase reporter assay and western blot confirmed that VEGFA was a direct target of miR-497;Subsequent investigations disclosed that Twist was regulated by miR-497 directly leading to the increased level of Vascular Endothelial Growth Factor-A VEGFA;We further disclosed that miR-497 exerted its function of anti-angiogenesis by suppressing VEGFA expression in ovarian cancer cells and in turn impairing the VEGFR2-mediated PI3K/AKT and MAPK/ERK pathways;Vascular endothelial growth factor-A VEGF-A was confirmed to be a target of miR-497 ;;metastasis;;;; breast cancer;lung squamous cell cancer;liver cancer;sarcoma;pancreatic cancer;ovarian cancer;colorectal cancer hsa-miR-504-5p VEGFA -0.510726779625117 6.12122269907368e-05 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate;miRTarBase -0.212758235683993 1.16548576784258e-10 NA NA NA hsa-miR-9-5p VEGFA -0.125377971246422 0.269896477802284 0.545202702414815 3.65580722751043e-08 miRNAWalker2_validate -0.372852027573008 5.51606960459938e-05 NA NA NA