miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-125a-5p ABHD3 0.599529391575274 0.0102300147180307 0.979765454097299 1.14506438092776e-07 PITA;miRanda -0.100262752298007 0.0101205484827566 NA NA NA hsa-miR-125a-5p ABL2 0.599529391575274 0.0102300147180307 -0.318835189302919 0.0455399452105181 MirTarget;PITA -0.215978868232166 2.65865236229228e-11 26766902 MicroRNA 125a 5p modulates human cervical carcinoma proliferation and migration by targeting ABL2; The direct regulation of miR-125a-5p on its target gene ABL proto-oncogene 2 ABL2 in cervical carcinoma was evaluated by quantitative real-time reverse transcription polymerase chain reaction Western blotting and luciferase reporter assays respectively; ABL2 was shown to be directly targeted by miR-125a-5p; In cervical carcinoma ABL2 gene and protein levels were both downregulated by miR-125a-5p cervical and endocervical cancer hsa-miR-125a-5p ACAT1 0.599529391575274 0.0102300147180307 -1.05404468189546 3.5026896380006e-07 miRanda -0.262636775978089 8.70716112896588e-10 NA NA NA hsa-miR-125a-5p ACTBL2 0.599529391575274 0.0102300147180307 1.67840376023074 0.00368292844578089 miRanda -0.666932106481877 2.12472754258851e-08 NA NA NA hsa-miR-125a-5p ACTG2 0.599529391575274 0.0102300147180307 -5.38617234928745 8.11220478446174e-16 miRanda -0.506255055696288 0.000438989529302931 NA NA NA hsa-miR-125a-5p ADAM19 0.599529391575274 0.0102300147180307 -1.06497039316686 0.0189522972551201 mirMAP -0.646721216938815 2.53088492257891e-12 NA NA NA hsa-miR-125a-5p ADAMTS14 0.599529391575274 0.0102300147180307 0.606090440489923 0.124791401560721 miRanda;mirMAP -0.231822252910962 0.00477537477813627 NA NA NA hsa-miR-125a-5p ADAMTS15 0.599529391575274 0.0102300147180307 -2.81260327679564 2.75117079085055e-06 mirMAP -0.812844362196262 5.02548272703547e-11 NA NA NA hsa-miR-125a-5p ADARB1 0.599529391575274 0.0102300147180307 -1.92780468757935 3.75403498492562e-10 mirMAP -0.259144005925514 6.88122738940188e-05 NA NA NA hsa-miR-125a-5p ADCY9 0.599529391575274 0.0102300147180307 -1.49969795166377 5.91319152843764e-09 mirMAP -0.315115226622442 4.52220736034437e-09 NA NA NA hsa-miR-125a-5p ADD2 0.599529391575274 0.0102300147180307 -0.716658990198397 0.25014925590144 MirTarget;miRanda -0.875708255060817 4.66278461336016e-12 NA NA NA hsa-miR-125a-5p ADM2 0.599529391575274 0.0102300147180307 2.23028154115795 1.94741275725572e-08 mirMAP -0.205489722625223 0.0146036090661644 NA NA NA hsa-miR-125a-5p ADPRH 0.599529391575274 0.0102300147180307 -0.709411240593381 0.00334479114857404 miRanda -0.208188987026147 3.32667593060291e-05 NA NA NA hsa-miR-125a-5p ADRB3 0.599529391575274 0.0102300147180307 -5.02331950531469 7.07932051511291e-18 miRanda -0.381320102834027 0.00256897592131913 NA NA NA hsa-miR-125a-5p AEN 0.599529391575274 0.0102300147180307 -0.364344818779911 0.0154093518747034 miRanda -0.119358707674611 0.000125722648135885 NA NA NA hsa-miR-125a-5p AFAP1L2 0.599529391575274 0.0102300147180307 0.0579969442179609 0.858094386575771 miRanda -0.144486840245356 0.0323406588806069 NA NA NA hsa-miR-125a-5p AGPAT4 0.599529391575274 0.0102300147180307 -0.794190742185859 0.0117424124328612 miRanda -0.256139125552408 9.04012625984177e-05 NA NA NA hsa-miR-125a-5p AGTRAP 0.599529391575274 0.0102300147180307 0.96364573709389 6.3796510491761e-07 miRNAWalker2_validate;miRanda -0.103483970905004 0.0111306871090744 NA NA NA hsa-miR-125a-5p AKAP11 0.599529391575274 0.0102300147180307 -0.801230576416459 1.137206260025e-06 miRanda -0.101996738211488 0.00318374605049845 NA NA NA hsa-miR-125a-5p AKAP13 0.599529391575274 0.0102300147180307 -1.14731602724292 2.3511548631978e-13 miRanda -0.176710879534094 9.11894167520395e-08 NA NA NA hsa-miR-101-3p AKT3 0.522819989585461 0.00375627731618038 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.334857831597034 0.000597756240419548 NA NA NA hsa-miR-106a-5p AKT3 2.48882002962836 1.99757727374521e-12 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.236478824223264 6.56988295029948e-07 NA NA NA hsa-miR-106b-5p AKT3 2.46782146831112 1.36171495805632e-23 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.521755012930227 1.0756262414999e-15 NA NA NA hsa-miR-107 AKT3 1.30977326593435 1.30372468603965e-11 -1.94162990884529 4.54380296394505e-08 PITA;miRanda -0.438321009170574 6.41595199298462e-07 NA NA NA hsa-miR-15a-5p AKT3 2.34669284378787 1.69544424500258e-23 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.653282073492048 2.38693369892811e-22 NA NA NA hsa-miR-15b-5p AKT3 1.57112623124278 9.14247846750597e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.4862313443712 1.80429141906685e-10 NA NA NA hsa-miR-16-5p AKT3 1.75824877145857 1.68592440033108e-16 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.527819854451446 1.06852141480407e-11 NA NA NA hsa-miR-17-3p AKT3 2.2704817679209 1.1667437320211e-22 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.393678889428456 2.72155279297878e-08 NA NA NA hsa-miR-17-5p AKT3 3.2710598467455 9.93128340539455e-27 -1.94162990884529 4.54380296394505e-08 TargetScan;miRNATAP -0.385876321416217 1.42856705542315e-13 NA NA NA hsa-miR-181a-5p AKT3 2.29556023480783 1.8138457900616e-21 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.283343247743329 3.77571043690309e-05 NA NA NA hsa-miR-181b-5p AKT3 2.49307679431293 3.92829250217627e-20 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.273550202394616 7.65012329836386e-06 NA NA NA hsa-miR-181c-5p AKT3 1.58587920618301 1.57506918816933e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.234902996176996 0.000670085449584041 NA NA NA hsa-miR-20a-5p AKT3 3.15577933619191 4.19753346442454e-25 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.397380097014522 3.56434655429537e-14 NA NA NA hsa-miR-20b-5p AKT3 2.07706563022469 1.10107236083433e-05 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.159136097484426 1.15057100055016e-05 NA NA NA hsa-miR-22-3p AKT3 1.21545661147757 1.61670170137775e-13 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.356198759053997 0.000637369773108939 NA NA NA hsa-miR-29b-2-5p AKT3 0.910668640983475 0.00666655585493488 -1.94162990884529 4.54380296394505e-08 mirMAP -0.413342005890553 1.74596670459023e-16 NA NA NA hsa-miR-29b-3p AKT3 1.65828197923813 1.02676780888141e-09 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.328715384299769 1.41956551647306e-07 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-29c-3p AKT3 -0.00968972577705429 0.97099586346872 -1.94162990884529 4.54380296394505e-08 miRNAWalker2_validate;miRNATAP -0.256484648428124 9.16722320814547e-05 NA NA NA hsa-miR-3065-5p AKT3 2.74629919868982 1.86846589298284e-08 -1.94162990884529 4.54380296394505e-08 mirMAP -0.196776388311872 4.09483787014971e-06 NA NA NA hsa-miR-32-3p AKT3 2.02436999565685 5.94091197945307e-09 -1.94162990884529 4.54380296394505e-08 mirMAP -0.274043726011417 8.75730973684685e-07 NA NA NA hsa-miR-320a AKT3 0.438165828017084 0.0390159073347133 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.539139659729602 3.01448987258332e-11 NA NA NA hsa-miR-320b AKT3 1.55692969039548 1.41071034251915e-08 -1.94162990884529 4.54380296394505e-08 PITA;miRanda;miRNATAP -0.376164976249955 1.04134326075959e-09 NA NA NA hsa-miR-335-3p AKT3 3.08791651139852 5.31309869723517e-12 -1.94162990884529 4.54380296394505e-08 mirMAP -0.222130607012057 2.63416728864213e-09 NA NA NA hsa-miR-33a-3p AKT3 1.72765312072219 1.51784443453521e-07 -1.94162990884529 4.54380296394505e-08 mirMAP -0.325733544419159 9.28241682908522e-09 NA NA NA hsa-miR-362-3p AKT3 2.0756816987665 3.89026064579331e-12 -1.94162990884529 4.54380296394505e-08 miRanda -0.16536843343699 0.0049777492806053 NA NA NA hsa-miR-362-5p AKT3 1.59303749908759 9.582675908797e-08 -1.94162990884529 4.54380296394505e-08 PITA;TargetScan;miRNATAP -0.201169258976553 0.000472996311050305 NA NA NA hsa-miR-374a-5p AKT3 0.484615721953736 0.0042981729815149 -1.94162990884529 4.54380296394505e-08 mirMAP -0.289501808595266 0.00547104114009117 NA NA NA hsa-miR-421 AKT3 1.17791565395543 6.78526676976629e-06 -1.94162990884529 4.54380296394505e-08 miRanda;mirMAP -0.270003673244585 4.40560995362011e-05 NA NA NA hsa-miR-501-3p AKT3 1.83132758513743 1.10971547702065e-10 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.357094776714992 1.69773165528929e-09 NA NA NA hsa-miR-502-3p AKT3 1.50560877085049 1.2647489756373e-11 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.326505295822604 2.04961437337709e-05 NA NA NA hsa-miR-505-3p AKT3 1.45322244209148 8.86597629645867e-10 -1.94162990884529 4.54380296394505e-08 mirMAP -0.409352554521824 1.03207996907079e-08 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-769-5p AKT3 1.82023760596845 9.6815886564134e-14 -1.94162990884529 4.54380296394505e-08 PITA;miRNATAP -0.445071301297515 6.71512496875401e-11 NA NA NA hsa-miR-93-5p AKT3 3.03961860136032 1.11672209617395e-24 -1.94162990884529 4.54380296394505e-08 miRNATAP -0.494281511913237 1.38435165024812e-20 NA NA NA hsa-miR-125a-5p ALDH1A3 0.599529391575274 0.0102300147180307 -1.34067722083045 0.00220013238089328 miRanda -0.285283338800848 0.00179979980364979 NA NA NA hsa-miR-125a-5p ALDH6A1 0.599529391575274 0.0102300147180307 -0.986263834792057 9.30752606118307e-06 miRanda -0.125549046304625 0.00721739669172811 NA NA NA hsa-miR-125a-5p ANKH 0.599529391575274 0.0102300147180307 -0.383033248037803 0.21653677802021 mirMAP -0.205155945864582 0.00143198779500377 NA NA NA hsa-miR-125a-5p ANKRD29 0.599529391575274 0.0102300147180307 -3.46821201627376 7.87727860045694e-10 MirTarget;miRanda -0.858847983151734 1.82731432615379e-13 NA NA NA hsa-miR-125a-5p ANKRD44 0.599529391575274 0.0102300147180307 -1.93020763162674 4.46055534768925e-08 miRanda -0.475801859372478 7.53916555063951e-11 NA NA NA hsa-miR-125a-5p ANKS6 0.599529391575274 0.0102300147180307 0.104145459586706 0.685675177215834 MirTarget -0.233186458756721 1.11350806449815e-05 NA NA NA hsa-miR-125a-5p ANPEP 0.599529391575274 0.0102300147180307 -0.910355136497126 0.0550970090453364 PITA;miRanda;miRNATAP -0.291606973982833 0.00316201933138207 NA NA NA hsa-miR-125a-5p ANTXR2 0.599529391575274 0.0102300147180307 -2.30617470732809 4.54834840057871e-13 PITA -0.27413139179502 5.41264576863461e-05 NA NA NA hsa-miR-125a-5p APC 0.599529391575274 0.0102300147180307 -0.603984431450045 0.000122196213200349 miRanda -0.206850857172122 1.35649172215922e-10 NA NA NA hsa-miR-125a-5p API5 0.599529391575274 0.0102300147180307 -0.197378516854822 0.061112135284605 miRanda -0.152613946230572 6.52657123882855e-13 NA NA NA hsa-miR-125a-5p ARHGAP11B 0.599529391575274 0.0102300147180307 2.25144445091096 5.3507914967411e-11 miRanda -0.248690118412225 0.000651900367441455 NA NA NA hsa-miR-125a-5p ARHGAP25 0.599529391575274 0.0102300147180307 -0.720365751328283 0.00654276279131097 miRanda -0.192033987150268 0.000492605786182371 NA NA NA hsa-miR-125a-5p ARL10 0.599529391575274 0.0102300147180307 -1.12227531152641 0.00197533796722557 mirMAP -0.459100081257773 7.00764169052738e-10 NA NA NA hsa-miR-125a-5p ARNTL 0.599529391575274 0.0102300147180307 -0.356733668497135 0.0895626680520666 miRanda -0.205542685977125 2.06007153634027e-06 NA NA NA hsa-miR-125a-5p ARSI 0.599529391575274 0.0102300147180307 -1.41753256004451 0.0217709211397789 MirTarget;miRanda -0.91525024517901 2.95658976588988e-13 NA NA NA hsa-miR-125a-5p ASB2 0.599529391575274 0.0102300147180307 -3.86455997344999 4.8427734086596e-17 miRanda -0.653205852635846 2.1763157052633e-11 NA NA NA hsa-miR-125a-5p ATL2 0.599529391575274 0.0102300147180307 -0.0776168881338366 0.649257882607437 miRNAWalker2_validate;miRanda -0.19963728114729 1.02471919841321e-08 NA NA NA hsa-miR-125a-5p ATP10D 0.599529391575274 0.0102300147180307 -0.688708018852498 0.010040565207979 MirTarget;miRanda -0.258386579100532 2.98733252813893e-06 NA NA NA hsa-miR-125a-5p ATP6V1B2 0.599529391575274 0.0102300147180307 -0.165407407015049 0.244743671039709 miRanda -0.166061507953068 1.0610085893783e-08 NA NA NA hsa-miR-125a-5p ATP8B2 0.599529391575274 0.0102300147180307 -1.89041258448176 1.15911506468727e-08 MirTarget -0.386495397166463 2.33325183699313e-08 NA NA NA hsa-miR-125a-5p ATP8B4 0.599529391575274 0.0102300147180307 -1.9014588444487 1.51297048489511e-09 miRanda -0.381832115808879 6.40610932237527e-09 NA NA NA hsa-miR-125a-5p ATXN1 0.599529391575274 0.0102300147180307 -1.5104377454496 2.95939614593378e-08 miRNAWalker2_validate;MirTarget;PITA;miRNATAP -0.295986197141884 2.03370095952866e-07 NA NA NA hsa-miR-125a-5p B2M 0.599529391575274 0.0102300147180307 -0.00374449202842086 0.988481900075066 miRanda -0.203707197913715 0.000146311442126184 NA NA NA hsa-miR-125a-5p B3GALNT2 0.599529391575274 0.0102300147180307 -0.598893719932316 3.47673736547777e-06 MirTarget;miRanda;miRNATAP -0.14797455352492 2.87893814589331e-08 NA NA NA hsa-miR-125a-5p B4GALNT1 0.599529391575274 0.0102300147180307 -0.588146250667548 0.294616335673503 miRanda -0.839952229218667 1.39336171976599e-13 NA NA NA hsa-miR-125a-5p BACE1 0.599529391575274 0.0102300147180307 -0.723461241968299 0.00095792938893533 mirMAP -0.183199789576015 5.7231758169554e-05 NA NA NA hsa-miR-125a-5p BAG4 0.599529391575274 0.0102300147180307 0.137093299664976 0.558111215664814 MirTarget -0.161132652933014 0.000894207412870646 NA NA NA hsa-miR-125a-5p BAK1 0.599529391575274 0.0102300147180307 0.761037514855449 0.000127844917586455 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.102790729960794 0.013506820665405 NA NA NA hsa-miR-125a-5p BATF2 0.599529391575274 0.0102300147180307 0.0630197357999309 0.892032016329026 miRanda -0.392275975936 4.37364437536817e-05 NA NA NA hsa-miR-125a-5p BAZ1A 0.599529391575274 0.0102300147180307 0.405723463620948 0.0101152042163839 miRanda -0.112619756860125 0.000580083131863263 NA NA NA hsa-miR-125a-5p BCAT1 0.599529391575274 0.0102300147180307 0.313527354263899 0.533186107238889 MirTarget -0.488287040292446 2.49992539780072e-06 NA NA NA hsa-miR-125a-5p BCL2 0.599529391575274 0.0102300147180307 -2.02088083891464 5.5300725103229e-13 PITA -0.204181839304005 0.000647180620809067 NA NA NA hsa-miR-125a-5p BEND6 0.599529391575274 0.0102300147180307 -0.802839399193567 0.0312762431852065 miRanda -0.353906694692426 4.38366516648396e-06 NA NA NA hsa-miR-125a-5p BIN2 0.599529391575274 0.0102300147180307 -0.820824541950989 0.0401832280892164 miRanda;miRNATAP -0.37667217720754 5.24486624273275e-06 NA NA NA hsa-miR-125a-5p BLZF1 0.599529391575274 0.0102300147180307 -0.383942446496747 0.012979598779123 miRanda -0.173667470159145 4.33895970647464e-08 NA NA NA hsa-miR-125a-5p BMP1 0.599529391575274 0.0102300147180307 0.194918683355282 0.453370270266782 mirMAP -0.135016657574522 0.0124803196365577 NA NA NA hsa-miR-125a-5p BMPR1B 0.599529391575274 0.0102300147180307 0.0707965297684667 0.914043396353822 MirTarget;miRNATAP -0.807051783523079 1.75213413272931e-09 NA NA NA hsa-miR-146b-5p BRAF 1.75587235896724 1.15724631266659e-07 -0.0380624164019494 0.839544086141468 miRanda -0.146633871679738 3.64395605099119e-08 21874046;26883911;20406109;21537871 Additionally the activation of thyroid most common oncogenes RET/PTC3 and BRAF in PCCL3 cells upregulated miR-146b-5p expression;miR-146b-5p positively regulates migration and invasion of thyroid normal and tumor follicular cells independently from their original mutation either BRAF or RET/PTC through a mechanism that involves the actin cytoskeleton but not an increased capacity of matrix degradation;The miR-146b expression levels in PTCs with BRAF mutation were significantly higher than those without this mutation p < 0.0001;Among BRAF-positive tumors overexpression of miR-146b was associated with aggressive behavior suggesting that it may further refine the prognostic importance of BRAF ;;; thyroid cancer;thyroid cancer;thyroid cancer;thyroid cancer hsa-miR-199a-5p BRAF 0.592984035153911 0.0674836634175293 -0.0380624164019494 0.839544086141468 miRanda -0.100551330747605 0.000311009640639109 NA NA NA hsa-miR-125a-5p BRCC3 0.599529391575274 0.0102300147180307 0.157692124219912 0.308139776927273 miRanda -0.129615678377061 4.85472156596178e-05 NA NA NA hsa-miR-125a-5p BRD3 0.599529391575274 0.0102300147180307 -0.158259683118194 0.29566181792188 miRanda -0.119445033826149 0.000131229005499241 NA NA NA hsa-miR-125a-5p BTC 0.599529391575274 0.0102300147180307 -1.89740785026816 7.90463026667505e-05 miRanda -0.26804216894594 0.00787466087239333 NA NA NA hsa-miR-125a-5p C2 0.599529391575274 0.0102300147180307 0.188441803451863 0.654648731594898 miRanda -0.229959585859563 0.00866265246525719 NA NA NA hsa-miR-103a-3p CAB39 1.44083190496858 1.53799939616416e-13 -0.477158523544161 0.00138539746274052 MirTarget;miRNATAP -0.172743294933037 1.59792620328537e-06 NA NA NA hsa-miR-151a-3p CAB39 1.24018761527407 1.08839919675408e-07 -0.477158523544161 0.00138539746274052 MirTarget -0.108706219270977 0.000381713653378672 NA NA NA hsa-miR-320a CAB39 0.438165828017084 0.0390159073347133 -0.477158523544161 0.00138539746274052 MirTarget;PITA;miRanda;miRNATAP -0.143026874546394 2.76474182066111e-05 NA NA NA hsa-miR-425-5p CAB39 3.07071373939774 4.02947460586085e-25 -0.477158523544161 0.00138539746274052 MirTarget -0.113641248897846 5.96290649580998e-07 NA NA NA hsa-miR-155-5p CAB39L 1.20164021433135 0.00086170622431261 -1.32713099101099 0.0016286153077432 miRNAWalker2_validate -0.465068952849233 1.19895211489865e-17 NA NA NA hsa-miR-214-5p CAB39L 0.962365243662358 0.0069147776948866 -1.32713099101099 0.0016286153077432 MirTarget -0.199486122647592 0.000482891477634037 NA NA NA hsa-miR-342-3p CAB39L 1.49115144672245 1.43879249744621e-07 -1.32713099101099 0.0016286153077432 miRanda -0.345811625519967 9.98604734821319e-07 NA NA NA hsa-miR-362-3p CAB39L 2.0756816987665 3.89026064579331e-12 -1.32713099101099 0.0016286153077432 miRanda -0.233526737377569 0.000701131740966757 NA NA NA hsa-miR-539-5p CAB39L 0.95216780650456 0.00284373332122135 -1.32713099101099 0.0016286153077432 mirMAP -0.156191725914134 0.0154148730579171 NA NA NA hsa-miR-590-3p CAB39L 2.59289455139753 1.03200520972022e-21 -1.32713099101099 0.0016286153077432 miRanda -0.271432757362025 0.000233995683821118 NA NA NA hsa-miR-590-5p CAB39L 3.18300989862077 2.06813568597893e-26 -1.32713099101099 0.0016286153077432 miRanda -0.216240907453537 0.00104450011172972 NA NA NA hsa-miR-7-1-3p CAB39L 1.84950311431067 1.25300363397654e-13 -1.32713099101099 0.0016286153077432 mirMAP -0.346297894182823 1.3001850315113e-05 NA NA NA hsa-miR-125a-5p CACNA1B 0.599529391575274 0.0102300147180307 0.253556623703701 0.683032730923114 MirTarget;miRanda;miRNATAP -0.277262584766978 0.0320491668243756 NA NA NA hsa-miR-125a-5p CAMK2A 0.599529391575274 0.0102300147180307 -4.13920739991396 5.06813084231462e-14 mirMAP -0.749271996568678 9.6185113835477e-11 NA NA NA hsa-miR-125a-5p CAND2 0.599529391575274 0.0102300147180307 -1.76877459687774 1.07837295224218e-05 miRanda -0.215201999402244 0.010910528417716 NA NA NA hsa-miR-125a-5p CAPZA2 0.599529391575274 0.0102300147180307 -0.830101934017935 8.41675881619737e-11 miRanda -0.112527510057181 2.97180935941924e-05 NA NA NA hsa-miR-125a-5p CBX6 0.599529391575274 0.0102300147180307 -1.53953176885359 2.83932741324751e-07 mirMAP -0.15809148847759 0.0125330184754495 NA NA NA hsa-miR-125a-5p CCDC91 0.599529391575274 0.0102300147180307 -0.406599245997386 0.0120328638669855 miRanda -0.119761804051016 0.000361379171375358 NA NA NA hsa-miR-125a-5p CCL5 0.599529391575274 0.0102300147180307 -0.0895483930596814 0.861084949069729 miRNAWalker2_validate -0.268997308903088 0.0115028456720051 NA NA NA hsa-miR-125a-5p CCR2 0.599529391575274 0.0102300147180307 -0.811487344053384 0.0911973481282995 miRanda -0.238516887274865 0.0172269415612883 NA NA NA hsa-miR-125a-5p CCR5 0.599529391575274 0.0102300147180307 -0.512428977177361 0.255082044245943 miRanda -0.448552134159262 1.33670561197602e-06 NA NA NA hsa-miR-125a-5p CD244 0.599529391575274 0.0102300147180307 -0.754111687515393 0.117014291971743 miRanda -0.230839857743084 0.0213422230609837 NA NA NA hsa-miR-125a-5p CD248 0.599529391575274 0.0102300147180307 -1.89164614483463 1.46235886389283e-07 PITA;miRanda;miRNATAP -0.232913102418632 0.00215303201503014 NA NA NA hsa-miR-125a-5p CD300LF 0.599529391575274 0.0102300147180307 0.49406801961588 0.244363420441934 miRNATAP -0.418635073471455 1.706693073105e-06 NA NA NA hsa-miR-125a-5p CD69 0.599529391575274 0.0102300147180307 -2.49390839555831 5.16539905545377e-07 miRanda -0.318893412590422 0.00232061991467567 NA NA NA hsa-miR-125a-5p CD72 0.599529391575274 0.0102300147180307 0.232568367896161 0.52819406697423 miRanda -0.188634348415274 0.0139244599087331 NA NA NA hsa-miR-125a-5p CD84 0.599529391575274 0.0102300147180307 -0.533438552489043 0.279469755133035 miRanda -0.66546020259873 3.44638942157807e-11 NA NA NA hsa-miR-125a-5p CD8A 0.599529391575274 0.0102300147180307 -0.716273738168588 0.147259256980763 miRanda -0.50555355176809 6.87890237712045e-07 NA NA NA hsa-miR-125a-5p CDA 0.599529391575274 0.0102300147180307 0.12517631637194 0.799512514397528 miRanda -0.43295306453406 2.11649369017237e-05 NA NA NA hsa-miR-125a-5p CDK17 0.599529391575274 0.0102300147180307 -0.521730808799873 0.000274477548938811 miRanda -0.133518318867474 6.94131305422503e-06 NA NA NA hsa-miR-125a-5p CDK5RAP2 0.599529391575274 0.0102300147180307 -0.434507358197935 0.00431389304028274 miRanda -0.200406045508058 1.098514715903e-10 NA NA NA hsa-miR-125a-5p CDKN2B 0.599529391575274 0.0102300147180307 -0.112970149969128 0.832353274540521 miRanda -0.310089305986085 0.00518147219807009 NA NA NA hsa-miR-125a-5p CEACAM21 0.599529391575274 0.0102300147180307 -0.149354345178603 0.726127228362001 miRanda -0.38890252660962 9.90279236610793e-06 NA NA NA hsa-miR-125a-5p CELF1 0.599529391575274 0.0102300147180307 -0.302262146915668 0.0178547827647846 mirMAP -0.146655081570853 1.936123206972e-08 NA NA NA hsa-miR-125a-5p CENPO 0.599529391575274 0.0102300147180307 1.81868479142635 1.66620849424989e-19 mirMAP -0.140614250430058 0.00130440772460776 NA NA NA hsa-miR-125a-5p CFLAR 0.599529391575274 0.0102300147180307 -0.231925856222684 0.202844044313639 miRanda -0.225494307449277 1.29185039963355e-09 NA NA NA hsa-miR-125a-5p CGREF1 0.599529391575274 0.0102300147180307 1.54072888475072 0.00763395740455696 MirTarget;miRanda -0.373729096309143 0.00191121832141008 NA NA NA hsa-miR-125a-5p CHD1 0.599529391575274 0.0102300147180307 -0.566940038213716 4.11672228164633e-05 miRanda -0.127264445553471 9.19886975652266e-06 NA NA NA hsa-miR-125a-5p CHRM3 0.599529391575274 0.0102300147180307 -2.47818923310211 2.99800179254763e-05 miRanda -0.601710133158081 1.10994012516352e-06 NA NA NA hsa-miR-125a-5p CHRNB2 0.599529391575274 0.0102300147180307 0.8982649980025 0.0265408963906376 mirMAP -0.256012289723383 0.00239632554787754 NA NA NA hsa-miR-125a-5p CKS1B 0.599529391575274 0.0102300147180307 1.71726683758774 1.66022226822098e-15 miRanda -0.125562782199209 0.00686566232867096 NA NA NA hsa-miR-125a-5p CLEC2B 0.599529391575274 0.0102300147180307 -0.835189349629304 0.0495809032042956 miRanda -0.393883342579101 7.52257534649843e-06 NA NA NA hsa-miR-125a-5p CNNM1 0.599529391575274 0.0102300147180307 -3.31155103745493 2.05706855156242e-09 PITA;miRanda -0.440830403131351 0.000161480397627198 NA NA NA hsa-miR-125a-5p CNTLN 0.599529391575274 0.0102300147180307 -1.17113354730787 0.00321990532892422 miRanda -0.537519769546029 3.79884006034725e-11 NA NA NA hsa-miR-125a-5p COL14A1 0.599529391575274 0.0102300147180307 -3.6564993981494 4.45153710546443e-17 miRanda -0.225609071491184 0.0168160244486145 NA NA NA hsa-miR-125a-5p COL1A2 0.599529391575274 0.0102300147180307 -0.907878215431927 0.0536183978525595 miRanda -0.319937796765224 0.00107219463707015 NA NA NA hsa-miR-125a-5p COL4A1 0.599529391575274 0.0102300147180307 0.151465916664922 0.581694470985045 miRNAWalker2_validate;miRanda -0.196409517018995 0.000565233811607909 NA NA NA hsa-miR-125a-5p CORO1C 0.599529391575274 0.0102300147180307 -1.12142787999647 2.05016310243217e-07 miRNAWalker2_validate -0.408060208695967 5.71127394896796e-21 NA NA NA hsa-miR-125a-5p CPT1A 0.599529391575274 0.0102300147180307 -0.825914268139749 0.000931222715881622 miRanda -0.212037260089397 4.3358418231808e-05 NA NA NA hsa-miR-125a-5p CR1 0.599529391575274 0.0102300147180307 -1.98900689989723 0.00029258945582881 miRanda -0.651343134587468 9.08616695733538e-09 NA NA NA hsa-miR-125a-5p CREB5 0.599529391575274 0.0102300147180307 -2.27679484644664 4.56595042875634e-09 miRNAWalker2_validate -0.532079783228008 4.14975524303849e-11 NA NA NA hsa-miR-125a-5p CREM 0.599529391575274 0.0102300147180307 -1.34537875047736 2.30173609087112e-14 miRanda -0.101580156389478 0.00724360171921327 NA NA NA hsa-miR-125a-5p CRK 0.599529391575274 0.0102300147180307 -0.602280866864171 4.11131295616185e-05 miRNAWalker2_validate -0.134944175246404 9.66088208277703e-06 NA NA NA hsa-miR-125a-5p CSF1 0.599529391575274 0.0102300147180307 -1.29812834960066 0.000329197071112557 mirMAP -0.395599645283962 1.22310594058424e-07 NA NA NA hsa-miR-125a-5p CSF2RB 0.599529391575274 0.0102300147180307 -0.739086291347396 0.0696045958228138 miRanda -0.426358007692611 3.75324813924671e-07 NA NA NA hsa-miR-125a-5p CTH 0.599529391575274 0.0102300147180307 -0.0186499184632679 0.955948212462526 miRanda -0.193888390387314 0.00570933097086343 NA NA NA hsa-miR-125a-5p CXCL13 0.599529391575274 0.0102300147180307 0.838324620103055 0.291567276966792 miRanda -0.98923941142542 1.15259191237056e-09 NA NA NA hsa-miR-125a-5p CYB5R4 0.599529391575274 0.0102300147180307 -0.0662677799042592 0.669802825862455 miRanda -0.151109918384973 2.19749330098854e-06 NA NA NA hsa-miR-125a-5p CYBB 0.599529391575274 0.0102300147180307 -0.863943628490373 0.0631881941766158 miRanda -0.612910092193399 1.07246163487324e-10 NA NA NA hsa-miR-125a-5p CYTH3 0.599529391575274 0.0102300147180307 -0.272207622459217 0.193434635786576 mirMAP -0.216875758149754 4.63560894894299e-07 NA NA NA hsa-miR-125a-5p CYTH4 0.599529391575274 0.0102300147180307 -0.800519740459215 0.0515273277425369 miRanda -0.469813156697799 2.66738330430371e-08 NA NA NA hsa-miR-125a-5p DAAM1 0.599529391575274 0.0102300147180307 -0.942213696830475 0.00027775597362759 MirTarget -0.362868736041077 7.62638741423532e-12 NA NA NA hsa-miR-125a-5p DCAF10 0.599529391575274 0.0102300147180307 -0.230423886050569 0.0644638559863325 MirTarget -0.143347916322499 1.78171897140994e-08 NA NA NA hsa-miR-125a-5p DCLK1 0.599529391575274 0.0102300147180307 -3.63128048984515 7.09770119804951e-11 miRanda -0.67607139463059 7.38311235997542e-09 NA NA NA hsa-miR-125a-5p DCTN1 0.599529391575274 0.0102300147180307 -0.349978452366152 0.000970363010229623 miRNATAP -0.10287736514159 2.4640414153786e-06 NA NA NA hsa-miR-101-3p DDIT4 0.522819989585461 0.00375627731618038 0.717938757137077 0.0430461225180125 miRNAWalker2_validate;MirTarget;miRNATAP -0.355155844720243 0.00021315858646136 NA NA NA hsa-miR-181c-5p DDIT4 1.58587920618301 1.57506918816933e-10 0.717938757137077 0.0430461225180125 MirTarget -0.145077871296069 0.0335547857337937 NA NA NA hsa-miR-181d-5p DDIT4 1.52204912185579 9.2693319057748e-08 0.717938757137077 0.0430461225180125 MirTarget -0.127310279952917 0.0330653294977689 NA NA NA hsa-miR-30b-5p DDIT4 0.800822374912712 0.000133601914525413 0.717938757137077 0.0430461225180125 MirTarget -0.231516620607933 0.00481015325205432 NA NA NA hsa-miR-30c-5p DDIT4 0.778774633108 0.000285599212429136 0.717938757137077 0.0430461225180125 MirTarget;miRNATAP -0.189580566588003 0.0182756104343371 NA NA NA hsa-miR-30d-5p DDIT4 0.675423997639582 0.00270618816039773 0.717938757137077 0.0430461225180125 MirTarget;miRNATAP -0.233442309312649 0.00227699320721357 NA NA NA hsa-miR-30e-5p DDIT4 1.23904909539663 1.35561917122157e-09 0.717938757137077 0.0430461225180125 MirTarget -0.279318696597116 0.000764635783021267 NA NA NA hsa-miR-32-5p DDIT4 2.34056473219422 6.24134585974322e-20 0.717938757137077 0.0430461225180125 miRNATAP -0.250841298923405 8.90809727205639e-05 NA NA NA hsa-miR-125a-5p DHFR 0.599529391575274 0.0102300147180307 0.46005901114512 0.0243179400013257 miRanda -0.175443297799228 3.32127504698115e-05 NA NA NA hsa-miR-125a-5p DHX33 0.599529391575274 0.0102300147180307 0.217875134421499 0.418256625509168 MirTarget;miRNATAP -0.216810699478094 9.84286534443992e-05 NA NA NA hsa-miR-125a-5p DIAPH3 0.599529391575274 0.0102300147180307 2.48599045917877 4.600772915308e-14 miRanda -0.381940658583797 4.58952661318884e-08 NA NA NA hsa-miR-125a-5p DIRAS1 0.599529391575274 0.0102300147180307 -3.18575368653498 5.11429118270038e-08 PITA;miRanda -0.396429017485348 0.00132934909761452 NA NA NA hsa-miR-125a-5p DLD 0.599529391575274 0.0102300147180307 -0.315733363533714 0.0111249074604642 MirTarget;miRanda -0.110530732149396 1.62890412644731e-05 NA NA NA hsa-miR-125a-5p DMC1 0.599529391575274 0.0102300147180307 -0.829496123864223 0.0643615588076449 miRanda -0.351325341841256 0.000159068997935017 NA NA NA hsa-miR-125a-5p DNAH11 0.599529391575274 0.0102300147180307 0.654856603817384 0.314234777813748 miRanda -0.608334616441597 5.93641814491492e-06 NA NA NA hsa-miR-125a-5p DNAJB5 0.599529391575274 0.0102300147180307 -2.65207059462743 2.68507855515511e-15 miRanda;miRNATAP -0.536025013295711 2.21236754418463e-14 NA NA NA hsa-miR-125a-5p DOCK11 0.599529391575274 0.0102300147180307 -1.79908213297826 2.03498791114807e-06 miRanda -0.50311016209854 1.24062705277703e-10 NA NA NA hsa-miR-125a-5p DPF3 0.599529391575274 0.0102300147180307 -1.66550931035639 8.31086463953742e-06 mirMAP -0.450519803686191 5.75225553315288e-09 NA NA NA hsa-miR-125a-5p DPP4 0.599529391575274 0.0102300147180307 -0.608566732904867 0.284453700468598 miRanda -0.632265904026766 6.13760111657124e-08 NA NA NA hsa-miR-125a-5p DPY19L2P2 0.599529391575274 0.0102300147180307 -1.07770489169219 0.00966424284480425 miRanda -0.334564431528412 0.000110297144487416 NA NA NA hsa-miR-125a-5p DPYD 0.599529391575274 0.0102300147180307 -1.70592656402028 0.000275323430264718 miRanda -0.626702620247027 7.47159951866452e-11 NA NA NA hsa-miR-125a-5p DPYSL3 0.599529391575274 0.0102300147180307 -2.3174606683978 1.31913973979472e-07 miRanda -0.499171360649967 5.04384910551149e-08 NA NA NA hsa-miR-125a-5p DRP2 0.599529391575274 0.0102300147180307 -1.34779224755633 0.000228883511200255 MirTarget -0.297581296924705 9.55760819035828e-05 NA NA NA hsa-miR-125a-5p DST 0.599529391575274 0.0102300147180307 -1.11542714896545 9.14769438027749e-05 mirMAP -0.169880804036748 0.0044601861348643 NA NA NA hsa-miR-125a-5p DSTN 0.599529391575274 0.0102300147180307 -1.57843644852196 1.87651771072391e-21 miRanda -0.166803534523868 3.511811947453e-06 NA NA NA hsa-miR-125a-5p DTNA 0.599529391575274 0.0102300147180307 -4.06049121456747 1.59577306327407e-12 miRanda -0.722372817277182 2.3625059946777e-09 NA NA NA hsa-miR-125a-5p DUSP3 0.599529391575274 0.0102300147180307 -1.04472877082381 6.16231013810421e-12 miRNAWalker2_validate -0.187985131427737 3.57029320961441e-09 NA NA NA hsa-miR-125a-5p DUSP7 0.599529391575274 0.0102300147180307 0.251956742030193 0.415548070412105 miRanda -0.252487441058183 8.00110477560952e-05 NA NA NA hsa-miR-125a-5p E2F2 0.599529391575274 0.0102300147180307 2.70854220767479 1.83941887423315e-16 MirTarget -0.301148309325287 2.03394231315254e-05 NA NA NA hsa-miR-125a-5p E2F7 0.599529391575274 0.0102300147180307 2.72477456699436 1.65128144770872e-15 miRNAWalker2_validate -0.216193375198121 0.00335951012201491 NA NA NA hsa-miR-125a-5p ECE1 0.599529391575274 0.0102300147180307 -0.286001205325721 0.0800860129032894 mirMAP -0.135435669504877 6.01830697699823e-05 NA NA NA hsa-miR-125a-5p ECE2 0.599529391575274 0.0102300147180307 1.99446603522994 1.59244129112654e-21 miRanda -0.145625231776208 0.00144756619861244 NA NA NA hsa-miR-125a-5p EGFR 0.599529391575274 0.0102300147180307 -0.229170429190265 0.593897211976523 mirMAP -0.455142512240812 2.58435389092739e-07 19881956;27094723;24484870 We report that EGFR signaling leads to transcriptional repression of the miRNA miR-125a through the ETS family transcription factor PEA3;Suppression of microRNA 125a 5p upregulates the TAZ EGFR signaling pathway and promotes retinoblastoma proliferation; Moreover the overexpression of miR-125a-5p led to a decrease in TAZ expression and downstream EGFR signaling pathway activation both in vitro and vivo; Finally TAZ overexpression in retinoblastoma cells overexpressing miR-125a-5p restored retinoblastoma cell proliferation and EGFR pathway activation; Taken together our data demonstrated that miR-125a-5p functions as an important tumor suppressor that suppresses the EGFR pathway by targeting TAZ to inhibit tumor progression in retinoblastoma;miR 125a regulates cell cycle proliferation and apoptosis by targeting the ErbB pathway in acute myeloid leukemia; Profiling revealed the ErbB pathway as significantly decreased with ectopic miR-125a; Either ectopic expression of miR-125a or inhibition of ErbB via Mubritinib resulted in inhibition of cell cycle proliferation and progression with enhanced apoptosis revealing ErbB inhibitors as potential novel therapeutic agents for treating miR-125a-low AML ;progression;progression ovarian cancer;retinoblastoma;acute myeloid leukemia hsa-miR-125a-5p EGR3 0.599529391575274 0.0102300147180307 -4.24788771954966 5.33225463207111e-21 PITA -0.448576491558628 4.78641103693514e-06 NA NA NA hsa-miR-103a-3p EIF4B 1.44083190496858 1.53799939616416e-13 -0.83546386425099 1.60081741236658e-10 MirTarget;miRNATAP -0.12384012181884 0.000120527401673825 NA NA NA hsa-miR-107 EIF4B 1.30977326593435 1.30372468603965e-11 -0.83546386425099 1.60081741236658e-10 MirTarget;PITA;miRanda;miRNATAP -0.116267081967539 0.000376104753401664 NA NA NA hsa-miR-15a-5p EIF4B 2.34669284378787 1.69544424500258e-23 -0.83546386425099 1.60081741236658e-10 miRNATAP -0.115102898094679 8.58712735181583e-06 NA NA NA hsa-miR-15b-5p EIF4B 1.57112623124278 9.14247846750597e-13 -0.83546386425099 1.60081741236658e-10 miRNATAP -0.108417564399088 0.000145863770523161 NA NA NA hsa-miR-16-5p EIF4B 1.75824877145857 1.68592440033108e-16 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.116626867681087 6.27326636466319e-05 NA NA NA hsa-miR-185-5p EIF4B 2.34016206907488 1.17481626642022e-26 -0.83546386425099 1.60081741236658e-10 MirTarget -0.163628340278415 2.05665506314812e-09 NA NA NA hsa-miR-193a-3p EIF4B 1.60460546928078 2.86169793322984e-07 -0.83546386425099 1.60081741236658e-10 miRanda -0.129748653727289 7.39065685686338e-11 NA NA NA hsa-miR-193b-3p EIF4B 2.25711804611899 4.1940744806631e-14 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate -0.131575191324763 1.39505544343809e-10 NA NA NA hsa-miR-25-3p EIF4B 1.36472605225697 4.83790725935681e-11 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate -0.106392733880944 0.000481532722887453 NA NA NA hsa-miR-342-3p EIF4B 1.49115144672245 1.43879249744621e-07 -0.83546386425099 1.60081741236658e-10 miRanda -0.126332356229928 1.1049251414087e-08 NA NA NA hsa-miR-362-3p EIF4B 2.0756816987665 3.89026064579331e-12 -0.83546386425099 1.60081741236658e-10 miRanda -0.161499044149002 1.7968030077065e-14 NA NA NA hsa-miR-423-3p EIF4B 2.57855385753676 9.19765570228097e-24 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate -0.131931378309889 1.88384562098769e-08 NA NA NA hsa-miR-424-5p EIF4B 1.61930224569578 1.89642549274994e-10 -0.83546386425099 1.60081741236658e-10 miRNATAP -0.129745405637866 1.30304622694912e-07 NA NA NA hsa-miR-484 EIF4B 1.81844463411787 1.82951571230938e-15 -0.83546386425099 1.60081741236658e-10 miRNAWalker2_validate -0.115522506643854 2.13739109619376e-05 NA NA NA hsa-miR-532-3p EIF4B 1.96631878320218 4.53421954361695e-13 -0.83546386425099 1.60081741236658e-10 miRNATAP -0.138783439415054 9.6358571664864e-10 NA NA NA hsa-miR-590-3p EIF4B 2.59289455139753 1.03200520972022e-21 -0.83546386425099 1.60081741236658e-10 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.10810967510776 2.80808517421654e-06 NA NA NA hsa-miR-125a-5p EIF4H 0.599529391575274 0.0102300147180307 -0.227863281526898 0.0254248627239351 miRanda -0.126125005289309 1.14609552994959e-09 NA NA NA hsa-miR-125a-5p EIF5A2 0.599529391575274 0.0102300147180307 -1.11920105116458 0.00497256140729196 PITA;miRanda -0.662171164988284 1.64814965791485e-16 NA NA NA hsa-miR-125a-5p ELOVL4 0.599529391575274 0.0102300147180307 -0.89569867087612 0.059608675377011 miRanda -0.75581105143908 3.31914640786109e-15 NA NA NA hsa-miR-125a-5p EMILIN2 0.599529391575274 0.0102300147180307 -0.479111133812053 0.112751872824804 miRanda -0.1654794974461 0.00848994125645392 NA NA NA hsa-miR-125a-5p ENKUR 0.599529391575274 0.0102300147180307 1.44941403140394 0.00183491337852834 miRanda -0.483687729594138 5.00944402038093e-07 NA NA NA hsa-miR-125a-5p ENO1 0.599529391575274 0.0102300147180307 0.863478122981125 1.12904995326978e-06 miRNAWalker2_validate -0.145153873677765 9.25535302183553e-05 NA NA NA hsa-miR-125a-5p ENPEP 0.599529391575274 0.0102300147180307 -0.330088475799641 0.366156594438613 PITA;miRanda -0.324236271139257 1.72913926012201e-05 NA NA NA hsa-miR-125a-5p ENTPD1 0.599529391575274 0.0102300147180307 -1.12219223948292 8.05257550730918e-10 miRanda -0.206582613153247 6.5810070869986e-08 NA NA NA hsa-miR-125a-5p EPHA6 0.599529391575274 0.0102300147180307 -3.7617134527257 2.58130561254474e-12 miRanda -0.641249887072072 1.53068300894567e-08 NA NA NA hsa-miR-125a-5p EPM2A 0.599529391575274 0.0102300147180307 -1.90233116870269 9.7764279872753e-23 miRanda -0.204302458697471 1.23786835793885e-06 NA NA NA hsa-miR-125a-5p ERMN 0.599529391575274 0.0102300147180307 0.435188365118196 0.314062796800707 miRanda -0.309016128310603 0.000568605085691308 NA NA NA hsa-miR-125a-5p ESPL1 0.599529391575274 0.0102300147180307 2.85443632204445 3.18991347452993e-21 miRanda -0.138205751804992 0.0367541002070204 NA NA NA hsa-miR-125a-5p FAM129A 0.599529391575274 0.0102300147180307 -2.92472325852437 7.78860786211284e-14 miRanda -0.686872501609963 2.09467379472331e-17 NA NA NA hsa-miR-125a-5p FAM129B 0.599529391575274 0.0102300147180307 0.0986544551232456 0.616324265821885 mirMAP;miRNATAP -0.119316883325423 0.00347384838456783 NA NA NA hsa-miR-125a-5p FAM131B 0.599529391575274 0.0102300147180307 -1.33611947709599 0.000824414564419036 miRanda -0.293970219693507 0.000419349743060779 NA NA NA hsa-miR-125a-5p FAM168A 0.599529391575274 0.0102300147180307 -0.715878355157019 0.0048087062534339 miRanda -0.366127879847102 1.36936683518385e-12 NA NA NA hsa-miR-125a-5p FAM27C 0.599529391575274 0.0102300147180307 0.0456976722153328 0.901033570745217 miRanda -0.245438237157925 0.00128442355272303 NA NA NA hsa-miR-125a-5p FAM53B 0.599529391575274 0.0102300147180307 -0.475921338658268 0.0133844063084078 mirMAP -0.106878685521474 0.00764642526203933 NA NA NA hsa-miR-125a-5p FAM78A 0.599529391575274 0.0102300147180307 -0.17566660865732 0.571673572062009 MirTarget -0.234424391728806 0.000267670329694731 NA NA NA hsa-miR-125a-5p FAT4 0.599529391575274 0.0102300147180307 -2.56665423966553 1.33682061275506e-12 miRanda -0.224159482758133 0.00379107740188175 NA NA NA hsa-miR-125a-5p FBXO10 0.599529391575274 0.0102300147180307 -0.376226305244078 0.0694286156419738 miRNAWalker2_validate -0.185834959754249 1.41004207370276e-05 NA NA NA hsa-miR-125a-5p FBXO45 0.599529391575274 0.0102300147180307 0.66379967538598 1.55745144003012e-05 PITA;miRanda -0.206516078769376 5.67760527957233e-11 NA NA NA hsa-miR-125a-5p FBXO48 0.599529391575274 0.0102300147180307 0.325274472289324 0.0512836794456615 miRanda -0.127939826514016 0.000212363188061584 NA NA NA hsa-miR-125a-5p FCGR1A 0.599529391575274 0.0102300147180307 1.09627251757513 0.0326970111845531 miRanda -0.551719082395586 1.81774514008194e-07 NA NA NA hsa-miR-125a-5p FEN1 0.599529391575274 0.0102300147180307 1.68632885020893 7.05115195970011e-15 miRanda -0.210089790526444 5.50722231015775e-06 NA NA NA hsa-miR-125a-5p FER 0.599529391575274 0.0102300147180307 -0.960481943610693 0.000174638463493531 miRanda -0.386865302077997 1.14076258716718e-13 NA NA NA hsa-miR-125a-5p FGD4 0.599529391575274 0.0102300147180307 -0.289427109821741 0.143341594254467 miRanda -0.141241416233838 0.000567221345731778 NA NA NA hsa-miR-125a-5p FIBIN 0.599529391575274 0.0102300147180307 -1.93483415962078 0.00101674691327545 miRanda -0.546955230583748 7.7293642202044e-06 NA NA NA hsa-miR-125a-5p FLG 0.599529391575274 0.0102300147180307 -1.67039963430072 0.012300818025345 miRanda -0.982828211111093 4.25120487547276e-13 NA NA NA hsa-miR-125a-5p FLRT2 0.599529391575274 0.0102300147180307 -2.6153026460413 1.63554627995384e-06 miRanda -0.667581200815665 3.60192116478825e-09 NA NA NA hsa-miR-125a-5p FLT3 0.599529391575274 0.0102300147180307 -1.96802952624864 2.65981345780205e-05 miRanda -0.263480704467921 0.0074248734779586 NA NA NA hsa-miR-125a-5p FLVCR2 0.599529391575274 0.0102300147180307 0.99889030331763 0.000193483372853479 miRanda -0.114063832658911 0.0425017534212385 NA NA NA hsa-miR-125a-5p FMNL3 0.599529391575274 0.0102300147180307 0.138843294816209 0.460998322398368 MirTarget;PITA -0.156965821659461 5.39867293316058e-05 NA NA NA hsa-miR-125a-5p FMO2 0.599529391575274 0.0102300147180307 -2.4057104016729 0.000137336354224179 MirTarget;miRanda -0.793561379216217 1.03398436962463e-09 NA NA NA hsa-miR-125a-5p FNBP1 0.599529391575274 0.0102300147180307 -1.88855087744431 6.2899280961967e-20 mirMAP -0.284575784003658 1.12622505761244e-10 NA NA NA hsa-miR-125a-5p FPR3 0.599529391575274 0.0102300147180307 -0.153358917350377 0.753240375960271 miRanda -0.504864149889552 4.88079843476415e-07 NA NA NA hsa-miR-125a-5p FUT4 0.599529391575274 0.0102300147180307 -0.253965820946868 0.347692658274243 MirTarget;PITA;miRanda;miRNATAP -0.118686793812941 0.0350214414241526 NA NA NA hsa-miR-125a-5p G2E3 0.599529391575274 0.0102300147180307 0.347057149517524 0.0206659754597155 miRNAWalker2_validate -0.10765402336818 0.000532618497978393 NA NA NA hsa-miR-125a-5p GAB2 0.599529391575274 0.0102300147180307 -1.20165054399091 1.06247685933273e-06 mirMAP -0.160573109900683 0.00193225961010046 NA NA NA hsa-miR-125a-5p GABRP 0.599529391575274 0.0102300147180307 0.0195783716200864 0.983288506607067 miRanda -0.912319732740895 2.18216726772442e-06 NA NA NA hsa-miR-125a-5p GANC 0.599529391575274 0.0102300147180307 -0.174109986132429 0.265576885873392 MirTarget;miRanda -0.117543428770267 0.000275495465519179 NA NA NA hsa-miR-125a-5p GATA6 0.599529391575274 0.0102300147180307 -3.38076408789276 2.92272151179456e-14 miRanda -0.450821039918013 1.96207886935079e-06 NA NA NA hsa-miR-125a-5p GBP5 0.599529391575274 0.0102300147180307 0.912417033493665 0.155449791355904 miRanda -0.949834696143404 2.93000450916544e-13 NA NA NA hsa-miR-125a-5p GCNT1 0.599529391575274 0.0102300147180307 0.0413031024334329 0.927473803129616 MirTarget;PITA;miRanda -0.442639971459259 2.19581788710226e-06 NA NA NA hsa-miR-125a-5p GCNT2 0.599529391575274 0.0102300147180307 -0.712162617542869 0.0826580493563988 miRanda -0.197060540567303 0.0212538170241 NA NA NA hsa-miR-125a-5p GEMIN5 0.599529391575274 0.0102300147180307 -0.199708326167447 0.120238384750959 miRanda -0.159227072255243 1.15698282782874e-09 NA NA NA hsa-miR-125a-5p GINS3 0.599529391575274 0.0102300147180307 1.20981267304007 3.53711996779243e-10 miRanda -0.155283621552827 0.000139936790841012 NA NA NA hsa-miR-125a-5p GJC1 0.599529391575274 0.0102300147180307 -0.972020676723743 0.00222017431601357 miRNATAP -0.271130031640132 4.00782824855244e-05 NA NA NA hsa-miR-125a-5p GLB1L3 0.599529391575274 0.0102300147180307 -0.321384248098787 0.588109033784362 miRanda -0.251776126307003 0.0417065528047766 NA NA NA hsa-miR-125a-5p GLIPR2 0.599529391575274 0.0102300147180307 -1.71383378993975 1.97331667161877e-06 miRanda -0.486680319502714 5.82568103584516e-11 NA NA NA hsa-miR-125a-5p GLP2R 0.599529391575274 0.0102300147180307 -5.63667677997636 1.56179085444134e-30 miRanda -0.440748014011464 5.69201672697048e-05 NA NA NA hsa-miR-125a-5p GLS 0.599529391575274 0.0102300147180307 -0.238702092034883 0.249312250754597 miRanda -0.19346539858217 5.88124372229707e-06 NA NA NA hsa-miR-125a-5p GNAO1 0.599529391575274 0.0102300147180307 -3.60402838064813 1.60858876204295e-14 mirMAP -0.66733896154331 1.39541707888953e-11 NA NA NA hsa-miR-125a-5p GPC6 0.599529391575274 0.0102300147180307 -2.70666453497929 7.48358520640858e-07 MirTarget;miRanda -0.671238616891047 3.34807722217823e-09 NA NA NA hsa-miR-125a-5p GPR107 0.599529391575274 0.0102300147180307 -0.00203501453786981 0.988266470833649 miRanda -0.122194347197564 1.75361845503714e-05 NA NA NA hsa-miR-125a-5p GPR153 0.599529391575274 0.0102300147180307 -0.458869487839193 0.138872941636277 miRanda -0.282076281130608 1.06124721520523e-05 NA NA NA hsa-miR-125a-5p GPR161 0.599529391575274 0.0102300147180307 -0.148318629076214 0.626304985069829 miRanda -0.296850676757221 2.2248265275269e-06 NA NA NA hsa-miR-125a-5p GRIN2A 0.599529391575274 0.0102300147180307 -3.3233994538381 1.07825857067501e-08 PITA -0.329789427479611 0.00743001945081907 NA NA NA hsa-miR-125a-5p GRIP2 0.599529391575274 0.0102300147180307 -0.728768151769827 0.0792229190736522 MirTarget -0.259652596845787 0.0026458551280813 NA NA NA hsa-miR-125a-5p HAP1 0.599529391575274 0.0102300147180307 1.35722527168172 0.00652115162914356 mirMAP -0.287088994005096 0.00584642678540961 NA NA NA hsa-miR-125a-5p HAS1 0.599529391575274 0.0102300147180307 -4.27045596328927 8.81209508699432e-11 miRanda -0.446496449699472 0.00143536235307665 NA NA NA hsa-miR-125a-5p HAT1 0.599529391575274 0.0102300147180307 0.030218632215874 0.829306838774288 miRanda -0.15519747010604 6.0217330844882e-08 NA NA NA hsa-miR-125a-5p HCG26 0.599529391575274 0.0102300147180307 0.138886741907037 0.696278564694051 miRanda -0.199905635021282 0.00686702802707285 NA NA NA hsa-miR-125a-5p HCP5 0.599529391575274 0.0102300147180307 0.704861835012558 0.0872850725771843 miRanda -0.289126582659234 1.66582867502827e-05 NA NA NA hsa-miR-125a-5p HECTD2 0.599529391575274 0.0102300147180307 -1.25606087758468 2.15810687487391e-09 miRanda -0.236436635317511 7.30272794354502e-08 NA NA NA hsa-miR-125a-5p HEPH 0.599529391575274 0.0102300147180307 -2.46988193403423 1.01671754481197e-08 miRanda -0.26419912545024 0.00381437259992874 NA NA NA hsa-miR-125a-5p HERC3 0.599529391575274 0.0102300147180307 -0.735977128364378 0.00165670204988658 miRanda -0.156786610673885 0.00130678775486828 NA NA NA hsa-miR-125a-5p HES2 0.599529391575274 0.0102300147180307 3.15368028997964 1.36111732082313e-05 mirMAP -0.623664663757654 3.87808098248482e-05 NA NA NA hsa-miR-125a-5p HHIPL1 0.599529391575274 0.0102300147180307 -0.820232944985923 0.0310227985532013 miRanda -0.229627539844336 0.00374363275496554 NA NA NA hsa-miR-106b-3p HIF1A 1.74115042407425 7.96524575137272e-14 -0.0887083952652183 0.694448347585856 miRNAWalker2_validate -0.115876573349366 0.01114041942823 NA NA NA hsa-miR-106b-5p HIF1A 2.46782146831112 1.36171495805632e-23 -0.0887083952652183 0.694448347585856 MirTarget -0.22506470406352 5.67731754915871e-08 NA NA NA hsa-miR-107 HIF1A 1.30977326593435 1.30372468603965e-11 -0.0887083952652183 0.694448347585856 miRNAWalker2_validate;miRTarBase;miRanda -0.123422589068387 0.0264755744668062 NA NA NA hsa-miR-151a-3p HIF1A 1.24018761527407 1.08839919675408e-07 -0.0887083952652183 0.694448347585856 MirTarget -0.16533909856988 0.000338305910074446 NA NA NA hsa-miR-20a-5p HIF1A 3.15577933619191 4.19753346442454e-25 -0.0887083952652183 0.694448347585856 miRNAWalker2_validate;miRTarBase;MirTarget -0.115406855575695 0.000600547799598935 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-28-5p HIF1A 0.230152919654905 0.0742909586754846 -0.0887083952652183 0.694448347585856 miRanda -0.410823482574077 2.0450455286232e-06 NA NA NA hsa-miR-330-3p HIF1A 0.876747334239085 0.00073709016089703 -0.0887083952652183 0.694448347585856 MirTarget;PITA -0.100136266436928 0.0170482873133228 NA NA NA hsa-miR-361-5p HIF1A 0.971859117235239 5.30236555707088e-09 -0.0887083952652183 0.694448347585856 miRanda -0.240248110278126 0.00022502129165918 NA NA NA hsa-miR-660-5p HIF1A 1.82692095272076 1.92040083607196e-13 -0.0887083952652183 0.694448347585856 MirTarget -0.138381785632354 0.00119715434144136 NA NA NA hsa-miR-93-5p HIF1A 3.03961860136032 1.11672209617395e-24 -0.0887083952652183 0.694448347585856 MirTarget -0.194707893705988 1.28811205175096e-08 NA NA NA hsa-miR-125a-5p HLA-DMB 0.599529391575274 0.0102300147180307 -0.407852560246717 0.31600539367086 miRanda -0.369626871658836 1.08035754475734e-05 NA NA NA hsa-miR-125a-5p HLA-DOA 0.599529391575274 0.0102300147180307 -0.788750104329619 0.0786620965309561 miRanda -0.202660866204272 0.0302959673651062 NA NA NA hsa-miR-125a-5p HLA-DQA2 0.599529391575274 0.0102300147180307 -0.801085089386468 0.15037729009529 miRanda -0.406817462039656 0.000432969397235534 NA NA NA hsa-miR-125a-5p HLA-F 0.599529391575274 0.0102300147180307 0.0884684181724635 0.824283197005505 miRanda -0.308931237507971 0.000180366141121599 NA NA NA hsa-miR-125a-5p HLA-H 0.599529391575274 0.0102300147180307 0.404639564186875 0.198400446518762 miRanda -0.235224817036019 0.000309964672086683 NA NA NA hsa-miR-125a-5p HOMER1 0.599529391575274 0.0102300147180307 0.0225289937147486 0.926783359078848 miRanda -0.158720646842882 0.00179591526063739 NA NA NA hsa-miR-125a-5p HPRT1 0.599529391575274 0.0102300147180307 0.802772982353988 2.5041780937918e-06 miRanda -0.114589776024823 0.00135240339604072 NA NA NA hsa-miR-125a-5p HSPA5 0.599529391575274 0.0102300147180307 0.588195194733105 2.93355432701435e-05 miRanda -0.110977306646353 0.000154033880193481 NA NA NA hsa-miR-125a-5p HSPB2 0.599529391575274 0.0102300147180307 -2.85103050430616 3.53689461443957e-14 PITA;miRanda -0.205128074645213 0.0112414765028265 NA NA NA hsa-miR-125a-5p HSPB7 0.599529391575274 0.0102300147180307 -4.50597115050814 3.65373161604345e-12 miRanda -0.450590454498037 0.00113124311380682 NA NA NA hsa-miR-125a-5p HTATIP2 0.599529391575274 0.0102300147180307 0.339622810841846 0.054025971438229 miRanda -0.124061830135859 0.00068674005555603 NA NA NA hsa-miR-125a-5p IFFO1 0.599529391575274 0.0102300147180307 -1.53820179896175 6.69728314861479e-07 MirTarget;miRNATAP -0.221335129156733 0.000672081876501113 NA NA NA hsa-miR-125a-5p IFNG 0.599529391575274 0.0102300147180307 0.730652903235741 0.241316232029331 miRanda -0.796445342539644 4.0129599473011e-10 NA NA NA hsa-let-7a-3p IGF1 1.42015538786275 7.03375209382654e-13 -3.75951127345565 1.26264890381366e-10 mirMAP -0.92426917804667 5.0725450948492e-11 NA NA NA hsa-let-7a-5p IGF1 0.618599506841644 2.76973453058748e-05 -3.75951127345565 1.26264890381366e-10 TargetScan -1.35484578107079 3.03432417502265e-12 NA NA NA hsa-let-7b-3p IGF1 0.868207752019623 1.30460056774366e-05 -3.75951127345565 1.26264890381366e-10 mirMAP -0.806527950481254 1.86996353532323e-08 NA NA NA hsa-let-7f-1-3p IGF1 1.55054488387679 7.31326775537952e-11 -3.75951127345565 1.26264890381366e-10 mirMAP -0.53583367534408 1.14955943868674e-05 NA NA NA hsa-miR-103a-2-5p IGF1 2.47599305985086 7.933028987326e-11 -3.75951127345565 1.26264890381366e-10 mirMAP -0.672288935268143 1.21134250789966e-16 NA NA NA hsa-miR-129-5p IGF1 -0.524170159980738 0.222582956006346 -3.75951127345565 1.26264890381366e-10 MirTarget;PITA;miRanda -0.24872412851026 0.000279350666200339 NA NA NA hsa-miR-130a-3p IGF1 2.02021855058359 1.26427102520415e-11 -3.75951127345565 1.26264890381366e-10 MirTarget -0.315325422858442 0.000861190344159203 NA NA NA hsa-miR-130b-3p IGF1 3.5350292994509 1.73934183852569e-27 -3.75951127345565 1.26264890381366e-10 MirTarget -0.781941096991651 4.63853079450254e-23 NA NA NA hsa-miR-148a-5p IGF1 1.16173838132242 0.000148929299881612 -3.75951127345565 1.26264890381366e-10 mirMAP -0.212992981754178 0.0236997428556886 NA NA NA hsa-miR-15b-3p IGF1 2.33847028227712 4.29662877950836e-19 -3.75951127345565 1.26264890381366e-10 mirMAP -1.14217010288885 5.28861971423639e-31 NA NA NA hsa-miR-16-1-3p IGF1 2.56983217111073 3.02262181237943e-20 -3.75951127345565 1.26264890381366e-10 mirMAP -0.921958602704484 2.5787665170735e-21 NA NA NA hsa-miR-181a-5p IGF1 2.29556023480783 1.8138457900616e-21 -3.75951127345565 1.26264890381366e-10 mirMAP -0.642043297035051 1.32592036628183e-08 NA NA NA hsa-miR-181b-5p IGF1 2.49307679431293 3.92829250217627e-20 -3.75951127345565 1.26264890381366e-10 mirMAP -0.697159274066391 2.64064192584975e-12 NA NA NA hsa-miR-181c-5p IGF1 1.58587920618301 1.57506918816933e-10 -3.75951127345565 1.26264890381366e-10 mirMAP -0.418006737238249 0.00025755851863695 NA NA NA hsa-miR-186-5p IGF1 1.47445398888668 3.0781726595413e-15 -3.75951127345565 1.26264890381366e-10 mirMAP -1.20504446214237 1.61828209547411e-16 NA NA NA hsa-miR-19a-3p IGF1 3.42309334186656 3.02671914353412e-28 -3.75951127345565 1.26264890381366e-10 MirTarget -0.788529625251502 2.31580352219079e-21 NA NA NA hsa-miR-19b-1-5p IGF1 2.57951428759379 4.31576118703427e-20 -3.75951127345565 1.26264890381366e-10 mirMAP -0.995592930242643 1.89907484758614e-25 NA NA NA hsa-miR-19b-3p IGF1 2.49529833021187 1.57028265846699e-23 -3.75951127345565 1.26264890381366e-10 MirTarget -1.0369004238185 3.24569264936101e-23 NA NA NA hsa-miR-20a-3p IGF1 2.92621109947706 2.49504904635375e-17 -3.75951127345565 1.26264890381366e-10 mirMAP -0.809636638775284 3.3899709447565e-25 NA NA NA hsa-miR-224-3p IGF1 1.87536386559317 6.15140969394846e-05 -3.75951127345565 1.26264890381366e-10 mirMAP -0.362328718988192 1.01049263740062e-08 NA NA NA hsa-miR-26b-5p IGF1 0.885393662798425 3.2116297961629e-06 -3.75951127345565 1.26264890381366e-10 mirMAP -0.940665920848216 3.14292070875382e-10 NA NA NA hsa-miR-27a-3p IGF1 1.66542180327138 4.93775737894805e-13 -3.75951127345565 1.26264890381366e-10 miRNAWalker2_validate;miRTarBase -0.651692554274928 7.73576562076687e-08 NA NA NA hsa-miR-29b-3p IGF1 1.65828197923813 1.02676780888141e-09 -3.75951127345565 1.26264890381366e-10 MirTarget -0.519110555190393 5.59140789276621e-07 25592039 Luciferase reporter assays were conducted to determine the association between miR-29b and the insulin-like growth factor 1 IGF1 3' untranslated region 3'UTR; IGF1 an activator of PI3K/Akt signaling was confirmed as a novel target of miR-29b colorectal cancer hsa-miR-301a-3p IGF1 2.81024345929638 2.29784847962242e-17 -3.75951127345565 1.26264890381366e-10 MirTarget -0.801898835472881 2.70419582744703e-21 NA NA NA hsa-miR-3065-5p IGF1 2.74629919868982 1.86846589298284e-08 -3.75951127345565 1.26264890381366e-10 mirMAP -0.340906479396581 1.44245852597366e-06 NA NA NA hsa-miR-32-3p IGF1 2.02436999565685 5.94091197945307e-09 -3.75951127345565 1.26264890381366e-10 mirMAP -0.670318737511073 1.52748719371215e-13 NA NA NA hsa-miR-320a IGF1 0.438165828017084 0.0390159073347133 -3.75951127345565 1.26264890381366e-10 miRNATAP -0.87110280497324 9.95766777508728e-11 NA NA NA hsa-miR-320b IGF1 1.55692969039548 1.41071034251915e-08 -3.75951127345565 1.26264890381366e-10 miRNATAP -0.993279990978514 6.22780218264885e-24 NA NA NA hsa-miR-33a-3p IGF1 1.72765312072219 1.51784443453521e-07 -3.75951127345565 1.26264890381366e-10 MirTarget -0.862622681654972 2.52525229105421e-21 NA NA NA hsa-miR-3607-3p IGF1 2.68532138541128 5.66716351955047e-14 -3.75951127345565 1.26264890381366e-10 mirMAP -0.646493669321152 1.00233762873621e-16 NA NA NA hsa-miR-361-5p IGF1 0.971859117235239 5.30236555707088e-09 -3.75951127345565 1.26264890381366e-10 PITA;mirMAP -1.48168691679158 5.53863901928066e-19 NA NA NA hsa-miR-374b-3p IGF1 0.930487774873495 2.74420094310516e-05 -3.75951127345565 1.26264890381366e-10 mirMAP -0.498455115159369 0.000129551554566347 NA NA NA hsa-miR-3913-5p IGF1 2.44353493655328 8.95279496632448e-15 -3.75951127345565 1.26264890381366e-10 mirMAP -0.584661382885468 7.3573353974355e-11 NA NA NA hsa-miR-421 IGF1 1.17791565395543 6.78526676976629e-06 -3.75951127345565 1.26264890381366e-10 PITA -0.696572691037999 1.11839961387445e-10 NA NA NA hsa-miR-452-5p IGF1 1.37180058737183 0.00171494843537772 -3.75951127345565 1.26264890381366e-10 MirTarget;mirMAP -0.239891308263067 0.000253591244736158 NA NA NA hsa-miR-454-3p IGF1 2.47234127820054 1.12878018736016e-21 -3.75951127345565 1.26264890381366e-10 MirTarget -0.897384141255581 2.08224455125487e-17 NA NA NA hsa-miR-486-5p IGF1 -0.194913133034028 0.607377798807705 -3.75951127345565 1.26264890381366e-10 PITA;miRNATAP -0.336416232300254 9.17459110593128e-06 NA NA NA hsa-miR-576-5p IGF1 2.20467023993664 3.4053475193793e-19 -3.75951127345565 1.26264890381366e-10 PITA;mirMAP;miRNATAP -1.00551072603292 1.14064166854676e-20 NA NA NA hsa-miR-590-3p IGF1 2.59289455139753 1.03200520972022e-21 -3.75951127345565 1.26264890381366e-10 MirTarget;miRanda;mirMAP;miRNATAP -0.845684857318828 5.27514597787573e-17 NA NA NA hsa-miR-592 IGF1 1.51765968871077 0.000636335248013204 -3.75951127345565 1.26264890381366e-10 mirMAP -0.450455314337535 2.70073065710591e-12 NA NA NA hsa-miR-629-5p IGF1 2.10182419359635 1.51788571125757e-15 -3.75951127345565 1.26264890381366e-10 mirMAP -0.693559501922869 2.74994850835533e-11 NA NA NA hsa-miR-664a-3p IGF1 0.634721925861133 0.00520070178640421 -3.75951127345565 1.26264890381366e-10 mirMAP -0.350873716989665 0.00610206128936229 NA NA NA hsa-miR-940 IGF1 3.21011374578759 2.7923171128495e-14 -3.75951127345565 1.26264890381366e-10 MirTarget;PITA;miRNATAP -0.715084793572266 1.27978685880086e-25 NA NA NA hsa-miR-125a-5p IGF2BP3 0.599529391575274 0.0102300147180307 2.6299525966699 0.000210097359173809 miRanda -0.527116556863016 0.000377765547713801 NA NA NA hsa-miR-125a-5p IGSF9B 0.599529391575274 0.0102300147180307 -3.70052179046043 2.07484176922388e-13 mirMAP -0.279699303869728 0.00970503489346359 NA NA NA hsa-miR-125a-5p IL10RA 0.599529391575274 0.0102300147180307 -1.37133661605832 0.000407351606953237 miRanda -0.417843492369792 1.9412670510322e-07 NA NA NA hsa-miR-125a-5p IL12RB2 0.599529391575274 0.0102300147180307 0.372769148854768 0.527723353953467 miRanda -1.07447825793945 5.64583370820825e-20 NA NA NA hsa-miR-125a-5p IL15RA 0.599529391575274 0.0102300147180307 -0.238342793156716 0.520044602405546 miRanda -0.443428545168732 4.95115382560526e-09 NA NA NA hsa-miR-125a-5p IL16 0.599529391575274 0.0102300147180307 -1.47099849326459 3.21424073431104e-07 MirTarget;PITA -0.210718009803483 0.000501537936403496 NA NA NA hsa-miR-125a-5p IL18BP 0.599529391575274 0.0102300147180307 0.398911859933675 0.0635405324088203 miRanda -0.13955438108727 0.00177642871185325 NA NA NA hsa-miR-125a-5p IL2RB 0.599529391575274 0.0102300147180307 -0.0233290268117248 0.954819309152745 miRanda -0.442253532537528 1.70969907539695e-07 NA NA NA hsa-miR-125a-5p IL6R 0.599529391575274 0.0102300147180307 -1.86576803083567 2.67166891084766e-06 MirTarget;miRanda -0.430695896757453 1.91909957244903e-07 NA NA NA hsa-miR-125a-5p IL7R 0.599529391575274 0.0102300147180307 -1.05033388888472 0.0658543700402536 miRanda -0.70343309526522 1.80486059514543e-09 NA NA NA hsa-miR-125a-5p IMPA2 0.599529391575274 0.0102300147180307 -1.29361497349091 2.74008616067664e-05 miRanda -0.535194617762013 8.52722160106018e-18 NA NA NA hsa-miR-125a-5p IPMK 0.599529391575274 0.0102300147180307 -0.315712743999597 0.410221785218579 miRanda -0.450981477245255 9.26920763811064e-09 NA NA NA hsa-miR-125a-5p IRF4 0.599529391575274 0.0102300147180307 -1.72341587118467 0.000316270812550294 miRanda -0.482979940044598 1.14539777186886e-06 NA NA NA hsa-miR-125a-5p IRX6 0.599529391575274 0.0102300147180307 -1.74681924923859 0.00290682055850392 miRanda -0.379071048892466 0.00196450395527473 NA NA NA hsa-miR-125a-5p ITGA7 0.599529391575274 0.0102300147180307 -3.00880253778842 7.00968987324051e-14 miRanda -0.28533355911411 0.000922109444108536 NA NA NA hsa-miR-125a-5p ITGA9 0.599529391575274 0.0102300147180307 -2.58466582885052 1.23539072812213e-10 MirTarget;PITA;miRanda -0.257555443860711 0.00257708453135463 NA NA NA hsa-miR-125a-5p ITGAX 0.599529391575274 0.0102300147180307 0.354183218808318 0.378093263465565 miRanda -0.407976918700202 8.15863511381571e-07 NA NA NA hsa-miR-125a-5p ITGB2 0.599529391575274 0.0102300147180307 -0.47094341720667 0.297854460695158 miRanda -0.510158066498813 3.90715484642447e-08 NA NA NA hsa-miR-125a-5p ITPK1 0.599529391575274 0.0102300147180307 -0.612797251697409 0.000244875275288488 mirMAP -0.132686581829816 0.000135277277085195 NA NA NA hsa-miR-125a-5p ITPKB 0.599529391575274 0.0102300147180307 -1.70322432049595 4.43562078746451e-23 mirMAP -0.190825634827559 3.28975367994844e-07 NA NA NA hsa-miR-125a-5p ITPR3 0.599529391575274 0.0102300147180307 1.43153215917791 6.96174864650177e-09 miRanda -0.175195050175372 0.000795333491080727 NA NA NA hsa-miR-125a-5p JPH1 0.599529391575274 0.0102300147180307 -1.13031137878183 0.00577247424420099 miRanda -0.237738588062622 0.00541231869464547 NA NA NA hsa-miR-125a-5p KCNAB2 0.599529391575274 0.0102300147180307 -0.720387769910192 0.0156755477759335 miRanda;mirMAP -0.371481603729535 1.1861271632016e-09 NA NA NA hsa-miR-125a-5p KCNB1 0.599529391575274 0.0102300147180307 -4.73054806319513 1.62745088879414e-20 miRanda -0.507407873418129 4.3598704572333e-06 NA NA NA hsa-miR-125a-5p KCNIP3 0.599529391575274 0.0102300147180307 -1.80534164990204 1.72863272403937e-06 PITA -0.281225289258919 0.000388484310840764 NA NA NA hsa-miR-125a-5p KCNJ12 0.599529391575274 0.0102300147180307 -2.26039929904991 2.90659346174232e-05 miRNATAP -0.617353715529212 3.58849000248826e-08 NA NA NA hsa-miR-125a-5p KCNK2 0.599529391575274 0.0102300147180307 -3.96205468288205 7.92099572968654e-12 miRanda -0.527173910861275 1.81142935021592e-05 NA NA NA hsa-miR-125a-5p KCNMA1 0.599529391575274 0.0102300147180307 -3.7780119035139 4.92766955950165e-16 PITA;miRanda -0.64867106475825 4.49838261102881e-11 NA NA NA hsa-miR-125a-5p KCNMB1 0.599529391575274 0.0102300147180307 -4.03172227703991 4.9889177140589e-17 miRanda -0.408818217370127 7.95439895711248e-05 NA NA NA hsa-miR-125a-5p KCTD15 0.599529391575274 0.0102300147180307 -1.06705874417742 0.00366825813765896 MirTarget -0.3195612420894 2.77724568348565e-05 NA NA NA hsa-miR-125a-5p KHK 0.599529391575274 0.0102300147180307 0.175275776379581 0.53390165566251 miRanda -0.202622948036822 0.000519317250608611 NA NA NA hsa-miR-125a-5p KIAA1644 0.599529391575274 0.0102300147180307 -4.40439862301283 1.42085780669109e-16 mirMAP -0.627826209217337 3.40828760355926e-08 NA NA NA hsa-miR-125a-5p KIF1C 0.599529391575274 0.0102300147180307 -0.511231532854291 0.00121474686364031 mirMAP -0.111514859633931 0.000691321283760231 NA NA NA hsa-miR-125a-5p KIF20B 0.599529391575274 0.0102300147180307 1.38918891544176 6.65494548949906e-10 miRanda -0.261416202182385 2.88030690841069e-08 NA NA NA hsa-miR-125a-5p KIF23 0.599529391575274 0.0102300147180307 2.70638055854579 1.87510526837343e-22 miRanda -0.265221863763643 1.17206470077086e-05 NA NA NA hsa-miR-125a-5p KIRREL 0.599529391575274 0.0102300147180307 -1.3733761261461 0.00482256440589364 miRanda;mirMAP -0.70363944191423 1.33712095625366e-12 NA NA NA hsa-miR-125a-5p KLF13 0.599529391575274 0.0102300147180307 -1.16141618366409 1.36372480238947e-05 miRNAWalker2_validate;MirTarget;PITA -0.420634996351092 1.04035731645716e-14 NA NA NA hsa-miR-125a-5p KLHL21 0.599529391575274 0.0102300147180307 -1.03680560428652 2.27490455113544e-07 mirMAP -0.282808715189738 7.17421272446223e-12 NA NA NA hsa-miR-125a-5p KLHL6 0.599529391575274 0.0102300147180307 -0.439336915926257 0.252335107184892 MirTarget;miRanda -0.229294111796046 0.00405584724686068 NA NA NA hsa-miR-125a-5p KLRC2 0.599529391575274 0.0102300147180307 0.337448491663343 0.54712028450451 MirTarget;miRanda -0.242991951428393 0.0374208557130083 NA NA NA hsa-miR-125a-5p KPNA6 0.599529391575274 0.0102300147180307 -0.135855055074388 0.164829034434512 MirTarget;PITA -0.115475229478826 6.09510348167082e-09 NA NA NA hsa-miR-125a-5p KRT74 0.599529391575274 0.0102300147180307 0.795401727555843 0.146688228412347 miRanda -0.277363118379465 0.0151346230755289 NA NA NA hsa-miR-125a-5p KSR1 0.599529391575274 0.0102300147180307 -0.329087326103332 0.188667705771067 miRanda;mirMAP -0.137754403358718 0.00813458450755502 NA NA NA hsa-miR-125a-5p KY 0.599529391575274 0.0102300147180307 -3.92273615985382 4.39505790976942e-15 miRanda -0.545831418496773 3.03776995770071e-07 NA NA NA hsa-miR-125a-5p L3MBTL4 0.599529391575274 0.0102300147180307 -1.82708463828674 0.000545506697076466 miRanda -0.557026851808361 3.58490113749878e-07 NA NA NA hsa-miR-125a-5p LAMA4 0.599529391575274 0.0102300147180307 -1.45595219375254 2.41526586222325e-06 miRanda -0.303220047597824 2.52964084512832e-06 NA NA NA hsa-miR-125a-5p LAMC2 0.599529391575274 0.0102300147180307 2.24370532975042 5.48773878317138e-05 MirTarget;miRanda -0.301052127742519 0.00995434131377062 NA NA NA hsa-miR-125a-5p LARP1 0.599529391575274 0.0102300147180307 0.226827037467584 0.0552261799558125 miRanda;mirMAP -0.106637030521907 1.17206711659063e-05 NA NA NA hsa-miR-125a-5p LATS2 0.599529391575274 0.0102300147180307 -1.50195936145544 2.88260453000506e-11 miRanda -0.21781018086606 5.01985416818712e-06 NA NA NA hsa-miR-125a-5p LBH 0.599529391575274 0.0102300147180307 0.0240918065859859 0.927864325672736 MirTarget;PITA;miRanda -0.170119811386754 0.00205799306609896 NA NA NA hsa-miR-125a-5p LEPROT 0.599529391575274 0.0102300147180307 -0.817800808666002 0.00547149005556457 MirTarget -0.312162922435305 2.77579139329756e-07 NA NA NA hsa-miR-125a-5p LGI3 0.599529391575274 0.0102300147180307 -1.49184233589231 0.00457104070075613 miRanda -0.261005401192916 0.0176568770138339 NA NA NA hsa-miR-125a-5p LIFR 0.599529391575274 0.0102300147180307 -2.63259527057529 1.38063075823569e-10 PITA -0.353066511590583 4.81920363330357e-05 25962054 Gain of function and loss of function of LIFR directly correlated with the inhibition and overexpression of miR-125a respectively; We further demonstrated that miR-125a influenced stem cells by regulating Hippo signaling through LIFR in human primary breast cancer cells confirming the data obtained from established cell lines breast cancer hsa-miR-125a-5p LILRA2 0.599529391575274 0.0102300147180307 -1.24095959851205 0.00156776433133967 miRanda -0.243456347946163 0.00298310053481004 NA NA NA hsa-miR-125a-5p LILRA6 0.599529391575274 0.0102300147180307 -0.0347972370317504 0.944751552299703 miRanda -0.668353454376862 6.27865533554208e-11 NA NA NA hsa-miR-125a-5p LIPA 0.599529391575274 0.0102300147180307 0.106533912387659 0.600754103914167 MirTarget;miRanda -0.17103614329712 4.69939231806318e-05 NA NA NA hsa-miR-125a-5p LMNB1 0.599529391575274 0.0102300147180307 2.07544777816029 3.21160770244475e-19 miRanda -0.177015700610883 0.000425894940903369 NA NA NA hsa-miR-125a-5p LNPEP 0.599529391575274 0.0102300147180307 -0.552309477369569 0.0283916452484756 MirTarget;PITA;miRanda -0.357511256955821 2.95671294192407e-12 NA NA NA hsa-miR-125a-5p LOXL3 0.599529391575274 0.0102300147180307 -0.968455677583596 0.000809448004647299 PITA;miRanda -0.24189516780015 5.781791505839e-05 NA NA NA hsa-miR-125a-5p LPIN1 0.599529391575274 0.0102300147180307 -0.89601675169461 0.000133989377531311 miRanda -0.178626212133501 0.000264042152084099 NA NA NA hsa-miR-125a-5p LPP 0.599529391575274 0.0102300147180307 -2.04092311415528 2.98839088727532e-15 mirMAP -0.340009649963981 5.06356580350031e-10 NA NA NA hsa-miR-125a-5p LRRC8A 0.599529391575274 0.0102300147180307 -0.573088385400785 0.00780133247798942 miRanda;miRNATAP -0.265869956867397 1.70871672014248e-09 NA NA NA hsa-miR-125a-5p LRRK2 0.599529391575274 0.0102300147180307 -3.1787789290057 4.20864823892524e-14 miRanda -0.558136444955599 3.17523380066649e-10 NA NA NA hsa-miR-125a-5p LSS 0.599529391575274 0.0102300147180307 -0.20229801582279 0.234544150283436 miRanda;mirMAP -0.110293973951015 0.00176031073399025 NA NA NA hsa-miR-125a-5p LST1 0.599529391575274 0.0102300147180307 -0.633444515190311 0.112530089157067 miRanda -0.287352909428745 0.000524505587766815 NA NA NA hsa-miR-125a-5p LUM 0.599529391575274 0.0102300147180307 -1.6117306534845 0.000480193345086782 miRanda -0.275408459944122 0.00436020669254113 NA NA NA hsa-miR-125a-5p LUZP1 0.599529391575274 0.0102300147180307 -0.517218843677563 0.000616513462077224 PITA;miRanda;mirMAP;miRNATAP -0.164833039001394 1.18552789984801e-07 NA NA NA hsa-miR-125a-5p LY86 0.599529391575274 0.0102300147180307 -0.857467892834654 0.0389409757037236 miRanda -0.342905479924333 6.81848152600799e-05 NA NA NA hsa-miR-125a-5p LYNX1 0.599529391575274 0.0102300147180307 -2.28496309981668 4.32425048267135e-07 mirMAP -0.391291312158137 3.70797509834879e-05 NA NA NA hsa-miR-125a-5p LYST 0.599529391575274 0.0102300147180307 -0.882294152711769 1.32902764923941e-05 miRanda -0.114634220112024 0.00700899999842526 NA NA NA hsa-miR-125a-5p MACF1 0.599529391575274 0.0102300147180307 -0.874277509919207 1.10820730213329e-06 miRNAWalker2_validate -0.277433848269515 3.78549993622081e-14 NA NA NA hsa-miR-125a-5p MAF 0.599529391575274 0.0102300147180307 -1.28341922239874 0.00015825213662883 miRNATAP -0.40881245655114 5.44234959558478e-09 NA NA NA hsa-miR-125a-5p MAFG 0.599529391575274 0.0102300147180307 -0.829357619313441 1.39267038703797e-06 mirMAP -0.188184362459939 1.34600811036305e-07 NA NA NA hsa-miR-125a-5p MAGI3 0.599529391575274 0.0102300147180307 -0.857868846049644 2.81850329980257e-05 miRanda -0.175932745176305 3.80403129462032e-05 NA NA NA hsa-miR-125a-5p MALL 0.599529391575274 0.0102300147180307 -1.09185560099452 0.0138972578280017 miRanda -0.291595732081891 0.00161071583440821 NA NA NA hsa-miR-125a-5p MAMDC2 0.599529391575274 0.0102300147180307 -4.37338158606787 1.8317884324613e-15 MirTarget;PITA;miRanda -0.509547847253375 1.53249159325188e-05 NA NA NA hsa-miR-125a-5p MAN2A1 0.599529391575274 0.0102300147180307 -0.416794055785883 0.126607782368129 miRanda -0.288301556604594 2.78548101770344e-07 NA NA NA hsa-miR-125a-5p MAP2 0.599529391575274 0.0102300147180307 -0.753572928246066 0.0970780637395552 miRanda -0.388641413378355 3.57465237963572e-05 NA NA NA hsa-miR-125a-5p MAP3K1 0.599529391575274 0.0102300147180307 0.427069954621904 0.0352041986280003 miRNAWalker2_validate -0.126195148873375 0.00275477598947122 NA NA NA hsa-miR-140-3p MAPK1 0.0608890720479334 0.727716871248724 -0.300413846088826 0.0202503240217449 PITA;miRNATAP -0.126850675206772 0.000457308593536618 NA NA NA hsa-miR-30c-5p MAPK1 0.778774633108 0.000285599212429136 -0.300413846088826 0.0202503240217449 mirMAP -0.161696427374548 1.83237959021178e-08 NA NA NA hsa-miR-30e-5p MAPK1 1.23904909539663 1.35561917122157e-09 -0.300413846088826 0.0202503240217449 mirMAP -0.123981973754552 3.68994437193015e-05 NA NA NA hsa-miR-34a-5p MAPK1 1.9016323452565 1.43092834643601e-14 -0.300413846088826 0.0202503240217449 mirMAP -0.113934200811126 2.89029232507908e-06 NA NA NA hsa-miR-125a-5p MAPK12 0.599529391575274 0.0102300147180307 0.275993547616267 0.337663040254231 miRNATAP -0.20965473468004 0.000440693435433499 NA NA NA hsa-miR-125a-5p MAPK14 0.599529391575274 0.0102300147180307 -0.303640775567793 0.00978869421579312 PITA;miRanda;miRNATAP -0.124626568360645 2.34301936142697e-07 NA NA NA hsa-miR-125a-5p MAPK8 0.599529391575274 0.0102300147180307 -0.0756707943151755 0.760488436744535 miRNAWalker2_validate -0.204776391145867 6.53898244404679e-05 NA NA NA hsa-miR-125a-5p MAPK8IP2 0.599529391575274 0.0102300147180307 1.53459732594152 0.00216669241202246 mirMAP -0.207731955170497 0.047527186700754 NA NA NA hsa-miR-125a-5p MAPKAPK2 0.599529391575274 0.0102300147180307 -0.224125552106657 0.0644502467861093 MirTarget;mirMAP -0.101734713265786 4.60987327357687e-05 NA NA NA hsa-miR-125a-5p MAPRE2 0.599529391575274 0.0102300147180307 -1.48556495228465 7.11230591567608e-09 MirTarget;PITA;miRanda -0.378163589199838 9.58357065272412e-13 NA NA NA hsa-miR-125a-5p MARVELD1 0.599529391575274 0.0102300147180307 -0.862056682483319 0.00342527025665607 mirMAP -0.161453820161463 0.00867888039857855 NA NA NA hsa-miR-125a-5p MBNL3 0.599529391575274 0.0102300147180307 -1.39664025928726 7.58496847232093e-05 miRNATAP -0.266610873091872 0.000301850609990342 NA NA NA hsa-miR-125a-5p MCL1 0.599529391575274 0.0102300147180307 -0.966384598042312 6.2852193244413e-09 MirTarget;PITA;miRanda -0.179850478189693 2.32572836009865e-07 NA NA NA hsa-miR-125a-5p MDC1 0.599529391575274 0.0102300147180307 0.0984839369817863 0.508759922629015 miRanda -0.105485509044234 0.000614924985179763 NA NA NA hsa-miR-125a-5p MDGA1 0.599529391575274 0.0102300147180307 -1.00154386684221 0.0303398006837731 mirMAP -0.466773388965177 1.01200590377595e-06 NA NA NA hsa-miR-125a-5p MED22 0.599529391575274 0.0102300147180307 -0.215675311163255 0.149773111169689 mirMAP -0.145612989596137 2.23759815832904e-06 NA NA NA hsa-miR-125a-5p MEGF9 0.599529391575274 0.0102300147180307 -0.640753905897188 0.00228374865870751 miRanda -0.106422180031486 0.0152756502518193 NA NA NA hsa-miR-125a-5p MEOX2 0.599529391575274 0.0102300147180307 -3.61789278989885 4.47845225204255e-09 miRanda -0.544459170163653 2.84313401586116e-05 NA NA NA hsa-miR-125a-5p MFHAS1 0.599529391575274 0.0102300147180307 -1.01931640398349 0.00156582848836066 MirTarget;PITA;miRanda;miRNATAP -0.634157820613904 3.27482218252486e-23 NA NA NA hsa-miR-125a-5p MGLL 0.599529391575274 0.0102300147180307 -2.48732319146401 3.44507421282234e-14 mirMAP -0.205730741093549 0.00350342975517249 NA NA NA hsa-miR-125a-5p MIB1 0.599529391575274 0.0102300147180307 -0.339857797544846 0.0363886788948554 PITA -0.145876884245387 1.34868177641336e-05 NA NA NA hsa-miR-125a-5p MICAL2 0.599529391575274 0.0102300147180307 -0.293088319173549 0.277386808748425 miRanda -0.177873337465803 0.00148990405590453 NA NA NA hsa-miR-125a-5p MICAL3 0.599529391575274 0.0102300147180307 -0.478666395164057 0.00314441556551914 mirMAP -0.131345852375069 9.30388814868338e-05 NA NA NA hsa-miR-125a-5p MICALL1 0.599529391575274 0.0102300147180307 -0.172653501838464 0.385305101692366 MirTarget;miRanda;mirMAP -0.100879923961308 0.0146228070151878 NA NA NA hsa-miR-125a-5p MOSPD2 0.599529391575274 0.0102300147180307 -0.0575047683137471 0.786259333133648 miRanda -0.134214024193209 0.00226717321099441 NA NA NA hsa-miR-125a-5p MPHOSPH9 0.599529391575274 0.0102300147180307 0.440839513794064 0.0622608148167444 miRanda -0.307452642082945 1.85356134664996e-10 NA NA NA hsa-miR-125a-5p MRPL50 0.599529391575274 0.0102300147180307 0.0863989333869712 0.521642842185032 miRNAWalker2_validate -0.12145906587409 1.17207930254716e-05 NA NA NA hsa-miR-125a-5p MS4A6A 0.599529391575274 0.0102300147180307 -0.907970768184375 0.0297535033577747 miRanda -0.433854422867267 4.76925630713892e-07 NA NA NA hsa-miR-125a-5p MSRB3 0.599529391575274 0.0102300147180307 -3.32124931554379 1.17358848755899e-14 MirTarget;PITA;miRanda -0.434751601720714 2.17340591115773e-06 NA NA NA hsa-miR-125a-5p MTF1 0.599529391575274 0.0102300147180307 -0.499080228357837 0.0010937181944664 MirTarget;PITA;miRanda;miRNATAP -0.212244641446785 9.4156720798732e-12 NA NA NA hsa-miR-125a-5p MYEOV 0.599529391575274 0.0102300147180307 2.58997980764458 0.00121763709382614 miRanda -0.464027680538259 0.00559703251926706 NA NA NA hsa-miR-125a-5p MYO18A 0.599529391575274 0.0102300147180307 -0.401017102072266 0.0293389863186551 MirTarget;miRanda -0.169587314005361 8.08293797743182e-06 NA NA NA hsa-miR-125a-5p MYO7A 0.599529391575274 0.0102300147180307 0.338482185821614 0.316197112331371 MirTarget;miRanda -0.382097907685162 3.46656340678088e-08 NA NA NA hsa-miR-125a-5p NBPF10 0.599529391575274 0.0102300147180307 -0.95665316939048 0.00235890681540488 miRanda -0.273895149944594 2.7580420769666e-05 NA NA NA hsa-miR-125a-5p NBPF14 0.599529391575274 0.0102300147180307 -0.474929522171104 0.0807282590012194 miRanda -0.231738661170122 3.8121764274475e-05 NA NA NA hsa-miR-125a-5p NBPF9 0.599529391575274 0.0102300147180307 0.344745146889186 0.22978371476869 MirTarget -0.211201878622858 0.000385943619322578 NA NA NA hsa-miR-125a-5p NCKAP5 0.599529391575274 0.0102300147180307 -0.565319863500383 0.215285536452686 miRanda -0.203153185483049 0.0326228322162477 NA NA NA hsa-miR-125a-5p NCOR2 0.599529391575274 0.0102300147180307 -0.35204425841984 0.0178506335854312 MirTarget;PITA;miRanda -0.138055933815879 6.66513522760593e-06 NA NA NA hsa-miR-125a-5p NDST1 0.599529391575274 0.0102300147180307 -0.250883286824299 0.176743296307116 mirMAP -0.226052828297584 2.53051446444669e-09 NA NA NA hsa-miR-125a-5p NEDD1 0.599529391575274 0.0102300147180307 0.304494605516126 0.0437074998080358 miRanda -0.168072238418078 5.58309511904424e-08 NA NA NA hsa-miR-125a-5p NEO1 0.599529391575274 0.0102300147180307 -0.77285961069625 0.00727512679084672 PITA -0.147919955362083 0.0138791871363195 NA NA NA hsa-miR-125a-5p NFAM1 0.599529391575274 0.0102300147180307 -0.407436496682177 0.299538525694089 mirMAP -0.399467862015277 7.81185441991698e-07 NA NA NA hsa-miR-125a-5p NFASC 0.599529391575274 0.0102300147180307 -2.95717922837883 4.31475260476481e-14 miRanda -0.528465334846113 1.50121535201974e-10 NA NA NA hsa-miR-125a-5p NFATC1 0.599529391575274 0.0102300147180307 -1.85038550878621 5.2595171540405e-08 miRanda -0.271857756138489 0.000146359188361828 NA NA NA hsa-miR-125a-5p NFIB 0.599529391575274 0.0102300147180307 -1.72909658442002 3.18902339154006e-09 PITA;miRNATAP -0.165633794054184 0.00748531475352699 NA NA NA hsa-miR-125a-5p NFIC 0.599529391575274 0.0102300147180307 -1.57099939804843 8.09399770340134e-09 mirMAP -0.529316490559432 5.38178933276238e-22 NA NA NA hsa-miR-125a-5p NID2 0.599529391575274 0.0102300147180307 -0.258478441141858 0.47664424728846 miRanda -0.307566040901224 4.1952730705068e-05 NA NA NA hsa-miR-125a-5p NIN 0.599529391575274 0.0102300147180307 -0.382020810876092 0.00757884761507996 miRNAWalker2_validate;miRanda -0.247376410102992 5.16348212780746e-18 NA NA NA hsa-miR-125a-5p NIPA1 0.599529391575274 0.0102300147180307 0.281277084596179 0.294239966944012 PITA -0.159827929112173 0.00411770344885097 NA NA NA hsa-miR-125a-5p NLRC5 0.599529391575274 0.0102300147180307 -0.00403114816697592 0.990433180502175 miRanda -0.477971688223236 2.35660496205543e-12 NA NA NA hsa-miR-125a-5p NMI 0.599529391575274 0.0102300147180307 0.624468137081556 0.00244260768082269 miRanda -0.182085065217641 2.02764957715212e-05 NA NA NA hsa-miR-125a-5p NOL9 0.599529391575274 0.0102300147180307 -0.127035676483221 0.341569049428339 mirMAP -0.138183385341404 4.40136330086121e-07 NA NA NA hsa-miR-125a-5p NOS1AP 0.599529391575274 0.0102300147180307 -0.285344944690239 0.418681562697865 miRanda -0.15857880813538 0.0308979868290541 NA NA NA hsa-miR-125a-5p NOTCH2 0.599529391575274 0.0102300147180307 -0.649665466220466 0.00179668614494204 miRanda -0.285076782974206 1.95022168914584e-11 NA NA NA hsa-miR-125a-5p NPM1 0.599529391575274 0.0102300147180307 -0.0167416493555219 0.908627168967763 miRNAWalker2_validate -0.156582626520759 1.56004103970428e-07 NA NA NA hsa-miR-125a-5p NPR3 0.599529391575274 0.0102300147180307 -1.7050337731335 0.000254565368348128 miRanda -0.27334474606011 0.00511976843501896 NA NA NA hsa-miR-125a-5p NPTX1 0.599529391575274 0.0102300147180307 -3.0548528465665 5.58655593069716e-09 mirMAP -0.313033766584046 0.00484472352056983 NA NA NA hsa-miR-125a-5p NRBF2 0.599529391575274 0.0102300147180307 0.0213500878241035 0.86456955175556 miRanda -0.154746010340943 1.17443767186542e-09 NA NA NA hsa-miR-125a-5p NRXN1 0.599529391575274 0.0102300147180307 -6.57168194390169 3.69107862170798e-26 MirTarget;miRanda -0.65143443225892 1.82815384050253e-06 NA NA NA hsa-miR-125a-5p NT5E 0.599529391575274 0.0102300147180307 -1.32095136217544 0.00557630949266939 miRanda -0.35305832961467 0.000372808541660339 NA NA NA hsa-miR-125a-5p NUAK2 0.599529391575274 0.0102300147180307 0.198061985670004 0.58300876635474 miRanda -0.457928837926065 4.96932445538047e-10 NA NA NA hsa-miR-125a-5p NUP205 0.599529391575274 0.0102300147180307 0.372795536895381 0.0115665143938007 miRanda -0.180849838548515 2.07270451280611e-09 NA NA NA hsa-miR-125a-5p OAS3 0.599529391575274 0.0102300147180307 1.29341517571326 4.25438611206689e-06 mirMAP -0.168072464901991 0.00448024736901317 NA NA NA hsa-miR-125a-5p OLFML1 0.599529391575274 0.0102300147180307 -2.63819844236782 1.29082006394553e-13 miRanda -0.164137385714008 0.0320335656618462 NA NA NA hsa-miR-125a-5p OLFML2A 0.599529391575274 0.0102300147180307 -1.0263532421833 0.000962903460469688 MirTarget;PITA -0.232589944384347 0.000331712187390771 NA NA NA hsa-miR-125a-5p OSTM1 0.599529391575274 0.0102300147180307 -0.771975269003669 5.13573784724769e-06 miRNAWalker2_validate -0.139766965247144 7.74470005438671e-05 NA NA NA hsa-miR-125a-5p P2RX1 0.599529391575274 0.0102300147180307 -5.27976580474423 6.97759293196139e-17 miRanda -0.629873326257189 3.52421221164311e-06 NA NA NA hsa-miR-125a-5p PADI2 0.599529391575274 0.0102300147180307 0.350798700258555 0.404765415387607 miRanda -0.254522650397611 0.00362761531007676 NA NA NA hsa-miR-125a-5p PAFAH1B1 0.599529391575274 0.0102300147180307 -0.62946721230231 1.17182416777085e-09 MirTarget;PITA;miRanda -0.10644938788219 8.24788415338388e-07 NA NA NA hsa-miR-125a-5p PAM 0.599529391575274 0.0102300147180307 -1.35766444679164 1.04680437362722e-07 miRNAWalker2_validate -0.354081406921738 1.87154195214218e-11 NA NA NA hsa-miR-125a-5p PANX1 0.599529391575274 0.0102300147180307 -0.105347821781685 0.592014927257078 miRNAWalker2_validate;miRanda -0.255391878899229 1.71585091640839e-10 NA NA NA hsa-miR-125a-5p PARP11 0.599529391575274 0.0102300147180307 -0.454345565334757 0.111231023058835 miRanda -0.209845147891282 0.00039015855508809 NA NA NA hsa-miR-125a-5p PARP14 0.599529391575274 0.0102300147180307 0.882489702205507 2.3569204284267e-05 MirTarget;miRanda;miRNATAP -0.15086133327099 0.000549349872998563 NA NA NA hsa-miR-125a-5p PARVG 0.599529391575274 0.0102300147180307 -0.540849846118522 0.183707425919286 MirTarget;miRanda -0.324680201906226 0.000116867681471301 NA NA NA hsa-miR-125a-5p PAX5 0.599529391575274 0.0102300147180307 -1.22891527233864 0.0475460185287537 mirMAP -0.651349156077003 3.49048895564595e-07 NA NA NA hsa-miR-125a-5p PC 0.599529391575274 0.0102300147180307 0.632691801811286 0.0120811365234216 miRNAWalker2_validate -0.119427918341968 0.0232206130343044 NA NA NA hsa-miR-125a-5p PCDHGB2 0.599529391575274 0.0102300147180307 -1.30314051301867 0.00358800711486786 miRNAWalker2_validate -0.449448796560255 1.2097570519515e-06 NA NA NA hsa-miR-125a-5p PCGF6 0.599529391575274 0.0102300147180307 0.146913104064073 0.276922720687459 MirTarget;miRanda -0.102922886174535 0.000222687122409385 NA NA NA hsa-miR-125a-5p PDE3B 0.599529391575274 0.0102300147180307 -1.66520519469945 8.1313249446923e-06 miRanda -0.28434781873163 0.00027725325846802 NA NA NA hsa-miR-186-5p PDPK1 1.47445398888668 3.0781726595413e-15 -0.446682027133002 0.00835125010618968 mirMAP -0.125708876159213 0.00333632806915964 NA NA NA hsa-miR-22-5p PDPK1 1.88011544159252 1.63978222572222e-16 -0.446682027133002 0.00835125010618968 miRNATAP -0.181020438712566 1.45237356289081e-07 NA NA NA hsa-miR-29b-3p PDPK1 1.65828197923813 1.02676780888141e-09 -0.446682027133002 0.00835125010618968 mirMAP -0.109518325633884 0.000211964623360266 NA NA NA hsa-miR-342-3p PDPK1 1.49115144672245 1.43879249744621e-07 -0.446682027133002 0.00835125010618968 mirMAP -0.109793629457974 0.000113758361154384 NA NA NA hsa-miR-374a-3p PDPK1 0.533309330504947 0.00192918429705142 -0.446682027133002 0.00835125010618968 mirMAP -0.118308754113252 0.0142261349514195 NA NA NA hsa-miR-125a-5p PELI2 0.599529391575274 0.0102300147180307 -2.81494282257666 4.56195595087127e-14 PITA;miRanda -0.409736047957146 2.35005432511062e-07 NA NA NA hsa-miR-125a-5p PGAM5 0.599529391575274 0.0102300147180307 0.717284922817611 8.34486177014306e-06 miRanda -0.183568876445482 3.53345943397263e-08 NA NA NA hsa-miR-326 PGF 0.715313016136042 0.0610265683213359 0.82580882918736 0.0169544692696931 mirMAP -0.162219493325868 0.000221458535925083 NA NA NA hsa-miR-421 PGF 1.17791565395543 6.78526676976629e-06 0.82580882918736 0.0169544692696931 miRanda -0.141102218221589 0.0272665155908835 NA NA NA hsa-miR-125a-5p PGLYRP4 0.599529391575274 0.0102300147180307 2.15317826412698 0.00492333036831748 miRanda -0.713541868273834 6.96751336351298e-06 NA NA NA hsa-miR-125a-5p PHAX 0.599529391575274 0.0102300147180307 -0.215926337183526 0.0734830611845946 miRanda -0.156296237440478 1.76966539435243e-10 NA NA NA hsa-miR-125a-5p PHF19 0.599529391575274 0.0102300147180307 -0.569884194868888 0.0249085385065336 mirMAP -0.380280306676539 1.50628850513398e-13 NA NA NA hsa-miR-125a-5p PHYHIP 0.599529391575274 0.0102300147180307 -3.99834802867978 1.29887445710253e-14 MirTarget;PITA;miRNATAP -0.239597450052633 0.0321954543438479 NA NA NA hsa-miR-125a-5p PI16 0.599529391575274 0.0102300147180307 -8.91656008399622 2.79331944902377e-32 miRanda -0.342668391126143 0.0440715334639521 NA NA NA hsa-miR-126-5p PIK3CA 0.895338176458417 2.33372756450713e-05 -0.151828236462886 0.321284398928338 mirMAP -0.103377544898631 0.00298975306098663 NA NA NA hsa-miR-186-5p PIK3CA 1.47445398888668 3.0781726595413e-15 -0.151828236462886 0.321284398928338 mirMAP -0.101671973753504 0.00842161241015832 NA NA NA hsa-miR-320a PIK3CA 0.438165828017084 0.0390159073347133 -0.151828236462886 0.321284398928338 miRanda -0.153857910084833 9.6763748473785e-06 NA NA NA hsa-miR-10b-5p PIK3CD -0.155951595811628 0.555006386998027 -0.775351667927902 0.021645534884375 miRNAWalker2_validate -0.175760207889201 0.004748835358114 NA NA NA hsa-miR-1468-5p PIK3CD 0.0469536064343461 0.881810795145912 -0.775351667927902 0.021645534884375 MirTarget -0.223784917601258 1.49208556354691e-05 NA NA NA hsa-miR-29c-3p PIK3CD -0.00968972577705429 0.97099586346872 -0.775351667927902 0.021645534884375 mirMAP -0.250794863940076 4.41169066967662e-05 NA NA NA hsa-miR-30b-3p PIK3CD 0.834142820354026 0.000972582820878813 -0.775351667927902 0.021645534884375 MirTarget -0.531045557079738 2.22640594160628e-17 NA NA NA hsa-miR-30b-5p PIK3CD 0.800822374912712 0.000133601914525413 -0.775351667927902 0.021645534884375 MirTarget -0.411457344396036 9.99002635635066e-08 NA NA NA hsa-miR-30c-5p PIK3CD 0.778774633108 0.000285599212429136 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.461850084291099 7.5210996634642e-10 NA NA NA hsa-miR-30d-5p PIK3CD 0.675423997639582 0.00270618816039773 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.733785480070449 9.30689014359708e-27 NA NA NA hsa-miR-30e-5p PIK3CD 1.23904909539663 1.35561917122157e-09 -0.775351667927902 0.021645534884375 MirTarget -0.597650735147178 7.00788139486401e-15 NA NA NA hsa-miR-320a PIK3CD 0.438165828017084 0.0390159073347133 -0.775351667927902 0.021645534884375 miRanda -0.437629854617933 1.07773535518864e-08 NA NA NA hsa-miR-320b PIK3CD 1.55692969039548 1.41071034251915e-08 -0.775351667927902 0.021645534884375 miRanda -0.282783919094812 1.19379715607107e-06 NA NA NA hsa-miR-324-5p PIK3CD 2.95683728155095 1.32960514360912e-20 -0.775351667927902 0.021645534884375 miRanda -0.265511883710764 4.30342749668002e-08 NA NA NA hsa-miR-3913-5p PIK3CD 2.44353493655328 8.95279496632448e-15 -0.775351667927902 0.021645534884375 mirMAP -0.395313104822511 3.24743386923115e-15 NA NA NA hsa-miR-421 PIK3CD 1.17791565395543 6.78526676976629e-06 -0.775351667927902 0.021645534884375 miRanda -0.235490163150307 0.000146542275873157 NA NA NA hsa-miR-484 PIK3CD 1.81844463411787 1.82951571230938e-15 -0.775351667927902 0.021645534884375 MirTarget;miRNATAP -0.387158078139352 1.61214627982237e-08 NA NA NA hsa-miR-148b-3p PIK3CG 1.97815018171325 6.07715327281595e-26 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.598035215538084 7.05982657783629e-10 NA NA NA hsa-miR-26b-5p PIK3CG 0.885393662798425 3.2116297961629e-06 -1.04493260087656 0.00941484120426313 miRNAWalker2_validate -0.252635166842034 0.0140326902426817 NA NA NA hsa-miR-335-3p PIK3CG 3.08791651139852 5.31309869723517e-12 -1.04493260087656 0.00941484120426313 mirMAP -0.182751911295676 1.44284270796844e-05 NA NA NA hsa-miR-3607-3p PIK3CG 2.68532138541128 5.66716351955047e-14 -1.04493260087656 0.00941484120426313 mirMAP -0.166734433414221 0.00216182223501734 NA NA NA hsa-miR-421 PIK3CG 1.17791565395543 6.78526676976629e-06 -1.04493260087656 0.00941484120426313 miRanda -0.208294811185602 0.00505346682917229 NA NA NA hsa-miR-590-3p PIK3CG 2.59289455139753 1.03200520972022e-21 -1.04493260087656 0.00941484120426313 miRanda -0.160421801003692 0.0232620908281926 NA NA NA hsa-miR-101-5p PIK3R1 0.782067874775122 0.00443725251526842 -1.16357283690918 1.63774086027679e-06 MirTarget -0.115568250605295 0.00948870207662742 NA NA NA hsa-miR-103a-3p PIK3R1 1.44083190496858 1.53799939616416e-13 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.175702483843164 0.00322284399016944 NA NA NA hsa-miR-106b-5p PIK3R1 2.46782146831112 1.36171495805632e-23 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.24930934707311 3.35624085651532e-08 NA NA NA hsa-miR-107 PIK3R1 1.30977326593435 1.30372468603965e-11 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.201353514049413 0.000854368494298006 NA NA NA hsa-miR-127-5p PIK3R1 1.19850695520181 4.10976607177645e-05 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.164276045731973 4.35688271416755e-05 24004856 Integrated gene network analysis and text mining revealing PIK3R1 regulated by miR 127 in human bladder cancer; These findings provide new insights into the role of miRNAs in the pathway of cancer and give us a hypothesis that miR-127 might play a similar role in regulation and control of PIK3R1 bladder cancer hsa-miR-128-3p PIK3R1 1.63756041666078 6.79626586407187e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.134770050316621 0.0111594593028352 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85Ī± expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 2.54959518791507 5.26618591274892e-18 -1.16357283690918 1.63774086027679e-06 MirTarget -0.146009716288673 0.000153002833756534 NA NA NA hsa-miR-132-3p PIK3R1 0.156276992635384 0.408190812100704 -1.16357283690918 1.63774086027679e-06 MirTarget -0.197496588157407 0.00191277589406782 NA NA NA hsa-miR-15a-5p PIK3R1 2.34669284378787 1.69544424500258e-23 -1.16357283690918 1.63774086027679e-06 MirTarget -0.142181030175195 0.00308171212654804 NA NA NA hsa-miR-15b-5p PIK3R1 1.57112623124278 9.14247846750597e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203388250610072 0.000112366544945594 NA NA NA hsa-miR-16-2-3p PIK3R1 2.31623086727196 4.29838149388188e-20 -1.16357283690918 1.63774086027679e-06 MirTarget -0.207543782293348 3.49270114018875e-06 NA NA NA hsa-miR-16-5p PIK3R1 1.75824877145857 1.68592440033108e-16 -1.16357283690918 1.63774086027679e-06 MirTarget -0.20266090985161 0.000166722510489398 NA NA NA hsa-miR-17-5p PIK3R1 3.2710598467455 9.93128340539455e-27 -1.16357283690918 1.63774086027679e-06 MirTarget;TargetScan;miRNATAP -0.194269031204595 7.03363082546611e-08 NA NA NA hsa-miR-185-5p PIK3R1 2.34016206907488 1.17481626642022e-26 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.305558512858305 1.29388513669652e-09 NA NA NA hsa-miR-186-5p PIK3R1 1.47445398888668 3.0781726595413e-15 -1.16357283690918 1.63774086027679e-06 mirMAP -0.274872917366815 8.27585129634137e-06 NA NA NA hsa-miR-188-5p PIK3R1 2.52825126596644 6.78099435999778e-14 -1.16357283690918 1.63774086027679e-06 MirTarget -0.185661747772095 2.50402606338374e-07 NA NA NA hsa-miR-199a-3p PIK3R1 0.640600337515787 0.0380326905134914 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.156998919927599 4.11373421997523e-05 NA NA NA hsa-miR-199b-3p PIK3R1 0.643923492750702 0.0371742251925406 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.157124307871095 4.00275047495595e-05 NA NA NA hsa-miR-20a-5p PIK3R1 3.15577933619191 4.19753346442454e-25 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.184775072209508 3.70396511881761e-07 NA NA NA hsa-miR-21-5p PIK3R1 2.73773305747971 1.38864982139576e-43 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.344443286817705 1.08270725892964e-10 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 0.357878936470387 0.232446214501331 -1.16357283690918 1.63774086027679e-06 MirTarget -0.126995222417611 0.00147059810557586 NA NA NA hsa-miR-22-5p PIK3R1 1.88011544159252 1.63978222572222e-16 -1.16357283690918 1.63774086027679e-06 mirMAP -0.292552038138818 3.89552165607854e-09 NA NA NA hsa-miR-221-3p PIK3R1 0.451556679024397 0.0909808299917811 -1.16357283690918 1.63774086027679e-06 MirTarget -0.108240747635063 0.015387314456947 NA NA NA hsa-miR-222-3p PIK3R1 0.851783756239071 0.00266783568486918 -1.16357283690918 1.63774086027679e-06 MirTarget -0.122260306324505 0.00346350093932025 NA NA NA hsa-miR-29a-3p PIK3R1 -0.35074463683376 0.161238718982428 -1.16357283690918 1.63774086027679e-06 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.197768036084372 3.04095884680599e-05 NA NA NA hsa-miR-29b-3p PIK3R1 1.65828197923813 1.02676780888141e-09 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.226570180742736 9.59427672061032e-08 NA NA NA hsa-miR-3065-5p PIK3R1 2.74629919868982 1.86846589298284e-08 -1.16357283690918 1.63774086027679e-06 MirTarget;mirMAP;miRNATAP -0.121456370441073 3.04699134862982e-05 NA NA NA hsa-miR-369-3p PIK3R1 0.946781510019564 0.00134850306966842 -1.16357283690918 1.63774086027679e-06 PITA -0.165045838001649 3.68847028364345e-05 NA NA NA hsa-miR-409-3p PIK3R1 0.877551657794358 0.00171210686733898 -1.16357283690918 1.63774086027679e-06 mirMAP -0.105859697586648 0.0126015776971144 NA NA NA hsa-miR-424-5p PIK3R1 1.61930224569578 1.89642549274994e-10 -1.16357283690918 1.63774086027679e-06 MirTarget -0.203727044936863 7.79524954848401e-06 NA NA NA hsa-miR-450b-5p PIK3R1 1.69244418548325 1.68064054148881e-10 -1.16357283690918 1.63774086027679e-06 miRNATAP -0.119371689321084 0.0066882062526509 NA NA NA hsa-miR-455-3p PIK3R1 3.06093594997644 3.54590649799868e-16 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRNATAP -0.151223028806072 5.34851043578223e-07 NA NA NA hsa-miR-485-3p PIK3R1 0.442820096243914 0.166634696770945 -1.16357283690918 1.63774086027679e-06 mirMAP -0.104228852223792 0.00542492277409986 NA NA NA hsa-miR-493-5p PIK3R1 0.847772103665986 0.00528678068747754 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.141629319654 0.000286613564823519 NA NA NA hsa-miR-532-3p PIK3R1 1.96631878320218 4.53421954361695e-13 -1.16357283690918 1.63774086027679e-06 MirTarget -0.183574493282594 1.45132602336302e-05 NA NA NA hsa-miR-584-5p PIK3R1 2.7326672683732 9.92677936962233e-12 -1.16357283690918 1.63774086027679e-06 mirMAP -0.136506526285572 1.76178566940588e-06 NA NA NA hsa-miR-589-3p PIK3R1 2.51971841868825 2.39125940264107e-11 -1.16357283690918 1.63774086027679e-06 mirMAP -0.146863008859422 2.43953052082368e-05 NA NA NA hsa-miR-590-3p PIK3R1 2.59289455139753 1.03200520972022e-21 -1.16357283690918 1.63774086027679e-06 miRanda;mirMAP -0.251414695908109 2.6774008322444e-09 NA NA NA hsa-miR-590-5p PIK3R1 3.18300989862077 2.06813568597893e-26 -1.16357283690918 1.63774086027679e-06 MirTarget;PITA;miRanda;miRNATAP -0.233958943001206 5.13569363038349e-10 NA NA NA hsa-miR-629-3p PIK3R1 2.36570947321815 1.33458201201618e-11 -1.16357283690918 1.63774086027679e-06 MirTarget -0.157530213698435 2.37486100403133e-05 NA NA NA hsa-miR-93-5p PIK3R1 3.03961860136032 1.11672209617395e-24 -1.16357283690918 1.63774086027679e-06 MirTarget;miRNATAP -0.155676924698248 3.5347453293642e-05 NA NA NA hsa-miR-96-5p PIK3R1 4.89433085814374 1.92000659886961e-31 -1.16357283690918 1.63774086027679e-06 TargetScan;miRNATAP -0.102966561567807 0.000122371084822612 NA NA NA hsa-miR-1271-5p PIK3R3 0.970418832993172 0.000609742584380688 -0.627704444396048 0.00578594022892978 mirMAP -0.151257171385516 9.56593049733625e-05 NA NA NA hsa-miR-181a-5p PIK3R3 2.29556023480783 1.8138457900616e-21 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.108906602043709 0.0127134423930606 NA NA NA hsa-miR-18a-3p PIK3R3 2.14813400940323 2.23460809936028e-06 -0.627704444396048 0.00578594022892978 miRNAWalker2_validate -0.10342220794232 0.000634896497880219 NA NA NA hsa-miR-19a-3p PIK3R3 3.42309334186656 3.02671914353412e-28 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.120784849374387 0.0002630092907536 NA NA NA hsa-miR-19b-3p PIK3R3 2.49529833021187 1.57028265846699e-23 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.146052627292238 0.000482454548266062 NA NA NA hsa-miR-222-5p PIK3R3 1.25632771414778 0.000138653440511922 -0.627704444396048 0.00578594022892978 mirMAP -0.146201383530692 9.47483044017924e-06 NA NA NA hsa-miR-26b-5p PIK3R3 0.885393662798425 3.2116297961629e-06 -0.627704444396048 0.00578594022892978 miRNATAP -0.184498425433638 0.00145436639404193 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.55384379072167 4.76870585070176e-05 -0.627704444396048 0.00578594022892978 mirMAP -0.182944374912975 8.7655907053222e-10 NA NA NA hsa-miR-365a-3p PIK3R3 -0.0388985816963467 0.859114494267351 -0.627704444396048 0.00578594022892978 MirTarget -0.222976439335601 9.85809729911043e-06 NA NA NA hsa-miR-511-5p PIK3R3 1.04499312543772 0.00234126154508174 -0.627704444396048 0.00578594022892978 MirTarget -0.132527709680848 3.18921565069019e-05 25608840 MiR 511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3; We further demonstrated that miR-511 suppressed HCC cell proliferation migration and invasion by repressing PIK3R3 expression metastasis liver cancer hsa-miR-92a-3p PIK3R3 2.06460102658973 1.44784291084757e-19 -0.627704444396048 0.00578594022892978 MirTarget;miRNATAP -0.185970971603602 5.73870254874264e-05 NA NA NA hsa-miR-107 PIK3R5 1.30977326593435 1.30372468603965e-11 -0.990769658200862 0.00792713202187119 miRanda -0.533513362792699 4.18278914923372e-09 NA NA NA hsa-miR-125a-3p PIK3R5 1.24490295132072 5.26925231010328e-06 -0.990769658200862 0.00792713202187119 miRanda -0.135508023882326 0.0399369211652034 NA NA NA hsa-miR-125a-5p PIK3R5 0.599529391575274 0.0102300147180307 -0.990769658200862 0.00792713202187119 MirTarget;miRanda -0.398754902125041 2.22481895610409e-07 NA NA NA hsa-miR-182-5p PIK3R5 3.53923166221814 5.07781258121574e-21 -0.990769658200862 0.00792713202187119 MirTarget -0.391730270801049 4.50362857100536e-19 NA NA NA hsa-miR-185-5p PIK3R5 2.34016206907488 1.17481626642022e-26 -0.990769658200862 0.00792713202187119 MirTarget -0.277336834855249 0.000367374066791577 NA NA NA hsa-miR-18a-3p PIK3R5 2.14813400940323 2.23460809936028e-06 -0.990769658200862 0.00792713202187119 MirTarget -0.132688083528877 0.0077571943603639 NA NA NA hsa-miR-330-5p PIK3R5 1.15100069700871 4.85551805046014e-07 -0.990769658200862 0.00792713202187119 MirTarget;miRanda -0.220865262481851 0.00496435762424894 NA NA NA hsa-miR-944 PIK3R5 2.91186649218281 1.31574753528144e-06 -0.990769658200862 0.00792713202187119 mirMAP -0.201291119960673 1.82909637448261e-11 NA NA NA hsa-miR-125a-5p PKP1 0.599529391575274 0.0102300147180307 1.83379655673086 0.00742003205869955 MirTarget -0.625448288861335 1.06045374679984e-05 NA NA NA hsa-miR-125a-5p PLA2G5 0.599529391575274 0.0102300147180307 -2.98039017984699 5.45430675918713e-08 miRanda -0.43402319502752 0.000171953535886849 NA NA NA hsa-miR-125a-5p PLAGL1 0.599529391575274 0.0102300147180307 -1.25500277301073 0.000250804046443006 miRanda -0.320487919182771 6.85756164158305e-06 NA NA NA hsa-miR-125a-5p PLAU 0.599529391575274 0.0102300147180307 1.71904365882259 1.76767552555585e-05 miRanda -0.209630776760627 0.0127929219788999 NA NA NA hsa-miR-125a-5p PLD6 0.599529391575274 0.0102300147180307 -0.562213195926031 0.0286496017779667 miRanda -0.215811234242963 5.01684157046134e-05 NA NA NA hsa-miR-125a-5p PLEKHA4 0.599529391575274 0.0102300147180307 -1.32374784898308 0.000110539276163376 miRanda -0.272711648784001 0.00013593390945494 NA NA NA hsa-miR-125a-5p PLEKHA8 0.599529391575274 0.0102300147180307 0.447114676542392 0.00928563749637202 miRanda -0.17491125296454 7.89621634769406e-07 NA NA NA hsa-miR-125a-5p PLEKHM3 0.599529391575274 0.0102300147180307 -0.67250523933801 7.96919433369335e-05 MirTarget -0.106907994138172 0.00269690732947449 NA NA NA hsa-miR-125a-5p PLIN3 0.599529391575274 0.0102300147180307 0.214373128706409 0.188230066038647 miRanda -0.145823832163483 1.40223578856174e-05 NA NA NA hsa-miR-125a-5p PLS3 0.599529391575274 0.0102300147180307 -0.0514153240775643 0.833811256655388 miRNAWalker2_validate;miRanda -0.301578877971909 1.65673560412923e-09 NA NA NA hsa-miR-125a-5p PLSCR4 0.599529391575274 0.0102300147180307 -2.11946408050861 2.7227459394389e-09 miRanda -0.523620426758954 1.22733534060425e-12 NA NA NA hsa-miR-125a-5p PML 0.599529391575274 0.0102300147180307 0.472013019239781 0.0112370371054835 miRanda -0.102177704703746 0.00841162732032416 NA NA NA hsa-miR-125a-5p PNOC 0.599529391575274 0.0102300147180307 -0.772337833484534 0.199706219744043 miRanda -0.329517146882427 0.00858200559594163 NA NA NA hsa-miR-125a-5p POLR1A 0.599529391575274 0.0102300147180307 0.288169928524328 0.0751341579451263 miRanda;mirMAP -0.194892198794311 3.85279771683751e-09 NA NA NA hsa-miR-125a-5p POU2F1 0.599529391575274 0.0102300147180307 -0.0922454590182942 0.733636001316083 miRanda;mirMAP -0.138863162922177 0.0137323412391276 NA NA NA hsa-miR-125a-5p PPAT 0.599529391575274 0.0102300147180307 0.807308266850106 2.1064771175364e-06 MirTarget;PITA;miRanda -0.149107441119504 2.73122703552844e-05 NA NA NA hsa-miR-125a-5p PPM1D 0.599529391575274 0.0102300147180307 -0.219425016956042 0.154255437850909 miRanda -0.118313398242185 0.000201229247258851 NA NA NA hsa-miR-125a-5p PPP2R3A 0.599529391575274 0.0102300147180307 -0.635587926025165 0.0133804555089022 miRanda -0.305968434195442 6.56251501119964e-09 NA NA NA hsa-miR-125a-5p PPP2R5C 0.599529391575274 0.0102300147180307 -0.521480329500893 1.91945462921615e-07 MirTarget;PITA;miRanda -0.115314852256606 2.48746606736075e-08 NA NA NA hsa-miR-125a-5p PPP2R5E 0.599529391575274 0.0102300147180307 -0.277275686002286 0.0553819870972808 miRNAWalker2_validate -0.203094773845661 4.35836001954904e-12 NA NA NA hsa-miR-125a-5p PRC1 0.599529391575274 0.0102300147180307 2.27144759121195 1.92890136197051e-19 miRNAWalker2_validate -0.229735830750059 2.50581960847354e-05 NA NA NA hsa-miR-125a-5p PRDM1 0.599529391575274 0.0102300147180307 -0.799773282697487 0.0106840144209139 PITA;miRanda -0.341052327510132 1.27134111994176e-07 NA NA NA hsa-miR-125a-5p PRDM6 0.599529391575274 0.0102300147180307 -3.30970199168442 3.91102712993692e-13 miRanda -0.231927230181501 0.0177777670203264 NA NA NA hsa-miR-125a-5p PRELP 0.599529391575274 0.0102300147180307 -4.33165618526589 1.8885949692004e-15 mirMAP -0.277399905667677 0.018410101244189 NA NA NA hsa-miR-125a-5p PRICKLE1 0.599529391575274 0.0102300147180307 -1.64440101214105 0.000132852800511825 miRanda -0.485707966204348 4.90641983848895e-08 NA NA NA hsa-let-7a-3p PRKAA2 1.42015538786275 7.03375209382654e-13 -3.1651157275578 4.06046613880045e-09 mirMAP -0.368546290584595 0.00514409913387135 NA NA NA hsa-let-7b-3p PRKAA2 0.868207752019623 1.30460056774366e-05 -3.1651157275578 4.06046613880045e-09 mirMAP -0.262674016711226 0.0494116538292108 NA NA NA hsa-let-7d-5p PRKAA2 1.33236798905207 1.1741085658466e-13 -3.1651157275578 4.06046613880045e-09 MirTarget -0.722750408548456 4.99138878435736e-07 NA NA NA hsa-let-7f-1-3p PRKAA2 1.55054488387679 7.31326775537952e-11 -3.1651157275578 4.06046613880045e-09 mirMAP -0.46638995733722 3.18954726371122e-05 NA NA NA hsa-let-7f-5p PRKAA2 0.495648727272215 0.00355972741198794 -3.1651157275578 4.06046613880045e-09 MirTarget -0.311815532548627 0.0490723533883445 NA NA NA hsa-let-7g-5p PRKAA2 1.20061455355116 1.50237505511483e-12 -3.1651157275578 4.06046613880045e-09 MirTarget -0.829014454032662 5.47891741707445e-08 NA NA NA hsa-let-7i-5p PRKAA2 0.412877696970403 0.00622731051981756 -3.1651157275578 4.06046613880045e-09 MirTarget -0.607502181924338 0.000681606877218508 NA NA NA hsa-miR-103a-2-5p PRKAA2 2.47599305985086 7.933028987326e-11 -3.1651157275578 4.06046613880045e-09 mirMAP -0.273304170202619 0.000379680069074106 NA NA NA hsa-miR-106b-5p PRKAA2 2.46782146831112 1.36171495805632e-23 -3.1651157275578 4.06046613880045e-09 mirMAP -0.449758621112524 9.45695175297387e-06 NA NA NA hsa-miR-125a-5p PRKAA2 0.599529391575274 0.0102300147180307 -3.1651157275578 4.06046613880045e-09 PITA -0.365087293868699 0.00135901058962619 NA NA NA hsa-miR-126-5p PRKAA2 0.895338176458417 2.33372756450713e-05 -3.1651157275578 4.06046613880045e-09 mirMAP -0.499415855416577 6.2491772215473e-05 NA NA NA hsa-miR-130b-3p PRKAA2 3.5350292994509 1.73934183852569e-27 -3.1651157275578 4.06046613880045e-09 MirTarget -0.30993060839259 4.53844629194696e-05 NA NA NA hsa-miR-141-3p PRKAA2 5.02396127982626 2.19224509139725e-24 -3.1651157275578 4.06046613880045e-09 mirMAP -0.311674641790567 3.76173236669185e-10 NA NA NA hsa-miR-142-5p PRKAA2 1.17581605694506 0.0018174701991234 -3.1651157275578 4.06046613880045e-09 mirMAP -0.307256732153854 1.00914367535293e-05 NA NA NA hsa-miR-146a-5p PRKAA2 1.19829319599115 0.00157081974524452 -3.1651157275578 4.06046613880045e-09 MirTarget -0.298359820970352 1.6416322978257e-05 NA NA NA hsa-miR-146b-5p PRKAA2 1.75587235896724 1.15724631266659e-07 -3.1651157275578 4.06046613880045e-09 MirTarget -0.311641849597315 7.38240690301751e-05 NA NA NA hsa-miR-15b-3p PRKAA2 2.33847028227712 4.29662877950836e-19 -3.1651157275578 4.06046613880045e-09 mirMAP -0.477684703528837 7.08126425805273e-07 NA NA NA hsa-miR-16-2-3p PRKAA2 2.31623086727196 4.29838149388188e-20 -3.1651157275578 4.06046613880045e-09 mirMAP -0.627940578646649 2.13766832392934e-10 NA NA NA hsa-miR-17-5p PRKAA2 3.2710598467455 9.93128340539455e-27 -3.1651157275578 4.06046613880045e-09 mirMAP -0.365611825057462 6.28601305540822e-06 NA NA NA hsa-miR-181a-2-3p PRKAA2 2.19062681262366 3.81790102612782e-13 -3.1651157275578 4.06046613880045e-09 mirMAP -0.446762077174767 1.28755345125413e-07 NA NA NA hsa-miR-181a-5p PRKAA2 2.29556023480783 1.8138457900616e-21 -3.1651157275578 4.06046613880045e-09 mirMAP -0.652763486781636 2.45814293770857e-10 NA NA NA hsa-miR-181b-5p PRKAA2 2.49307679431293 3.92829250217627e-20 -3.1651157275578 4.06046613880045e-09 mirMAP -0.553820083358037 1.79038809431955e-09 NA NA NA hsa-miR-182-5p PRKAA2 3.53923166221814 5.07781258121574e-21 -3.1651157275578 4.06046613880045e-09 miRNAWalker2_validate;MirTarget;mirMAP -0.331706760870251 5.94483360132956e-07 NA NA NA hsa-miR-186-5p PRKAA2 1.47445398888668 3.0781726595413e-15 -3.1651157275578 4.06046613880045e-09 MirTarget -0.526806950486461 0.000138268992490229 NA NA NA hsa-miR-192-5p PRKAA2 2.69002528723195 1.22990188194432e-16 -3.1651157275578 4.06046613880045e-09 miRNAWalker2_validate -0.161378715666907 0.0407539432354523 NA NA NA hsa-miR-19a-3p PRKAA2 3.42309334186656 3.02671914353412e-28 -3.1651157275578 4.06046613880045e-09 mirMAP -0.379428611341206 1.66931323472125e-06 NA NA NA hsa-miR-19b-3p PRKAA2 2.49529833021187 1.57028265846699e-23 -3.1651157275578 4.06046613880045e-09 mirMAP -0.447494148517396 8.06927629243583e-06 NA NA NA hsa-miR-200a-3p PRKAA2 4.59434485520731 6.38952518573476e-18 -3.1651157275578 4.06046613880045e-09 mirMAP -0.252415609716866 8.38336062600942e-08 NA NA NA hsa-miR-200b-3p PRKAA2 3.78235093249346 3.18343003239465e-14 -3.1651157275578 4.06046613880045e-09 MirTarget -0.261801092835381 2.7256487514151e-07 NA NA NA hsa-miR-200c-3p PRKAA2 3.50132673580082 2.42716349086937e-15 -3.1651157275578 4.06046613880045e-09 MirTarget -0.3165574137351 2.9537182424848e-08 NA NA NA hsa-miR-203a-3p PRKAA2 3.12352008343999 9.49391438647189e-07 -3.1651157275578 4.06046613880045e-09 MirTarget -0.114021445045374 0.00543014379350566 NA NA NA hsa-miR-20a-5p PRKAA2 3.15577933619191 4.19753346442454e-25 -3.1651157275578 4.06046613880045e-09 mirMAP -0.371335239957246 5.16233816597501e-06 NA NA NA hsa-miR-21-3p PRKAA2 2.19296355304364 4.63665722759779e-15 -3.1651157275578 4.06046613880045e-09 mirMAP -0.424686931257561 3.18678833497258e-06 NA NA NA hsa-miR-22-5p PRKAA2 1.88011544159252 1.63978222572222e-16 -3.1651157275578 4.06046613880045e-09 mirMAP -0.640613793079929 8.15181736251034e-09 NA NA NA hsa-miR-23a-3p PRKAA2 1.00493340843378 2.55313889288924e-08 -3.1651157275578 4.06046613880045e-09 mirMAP -0.717245625409375 7.83285299814301e-07 NA NA NA hsa-miR-26a-2-3p PRKAA2 0.823520019989974 0.00017092160823769 -3.1651157275578 4.06046613880045e-09 mirMAP -0.408717713181205 0.000788807753650383 NA NA NA hsa-miR-26a-5p PRKAA2 0.0464832722967259 0.752628386912329 -3.1651157275578 4.06046613880045e-09 mirMAP -0.397860835240243 0.0313650980967207 NA NA NA hsa-miR-26b-5p PRKAA2 0.885393662798425 3.2116297961629e-06 -3.1651157275578 4.06046613880045e-09 mirMAP -0.764962785810813 2.83597630191631e-08 NA NA NA hsa-miR-27b-5p PRKAA2 0.393316367667332 0.051702301924024 -3.1651157275578 4.06046613880045e-09 MirTarget;miRNATAP -0.383639737600614 0.0037825291986155 NA NA NA hsa-miR-29b-2-5p PRKAA2 0.910668640983475 0.00666655585493488 -3.1651157275578 4.06046613880045e-09 mirMAP -0.279808749959182 0.00038252900575232 NA NA NA hsa-miR-301a-3p PRKAA2 2.81024345929638 2.29784847962242e-17 -3.1651157275578 4.06046613880045e-09 MirTarget -0.231119799911066 0.0045176787682093 NA NA NA hsa-miR-30b-5p PRKAA2 0.800822374912712 0.000133601914525413 -3.1651157275578 4.06046613880045e-09 MirTarget -0.288057119153475 0.0233572155059335 NA NA NA hsa-miR-30c-5p PRKAA2 0.778774633108 0.000285599212429136 -3.1651157275578 4.06046613880045e-09 MirTarget -0.356922096763827 0.00395922355020181 NA NA NA hsa-miR-30d-3p PRKAA2 0.977747550180601 4.3048212205381e-05 -3.1651157275578 4.06046613880045e-09 MirTarget;miRNATAP -0.240071186464927 0.0307082267542837 NA NA NA hsa-miR-30d-5p PRKAA2 0.675423997639582 0.00270618816039773 -3.1651157275578 4.06046613880045e-09 MirTarget -0.271897797341097 0.0216937703176945 NA NA NA hsa-miR-30e-5p PRKAA2 1.23904909539663 1.35561917122157e-09 -3.1651157275578 4.06046613880045e-09 MirTarget -0.575531898888406 6.37486734638196e-06 NA NA NA hsa-miR-31-5p PRKAA2 3.59165123035072 2.27423212057482e-07 -3.1651157275578 4.06046613880045e-09 MirTarget -0.151730039535611 0.000135936484549104 NA NA NA hsa-miR-32-3p PRKAA2 2.02436999565685 5.94091197945307e-09 -3.1651157275578 4.06046613880045e-09 MirTarget -0.205177944089292 0.0165918636397811 NA NA NA hsa-miR-330-3p PRKAA2 0.876747334239085 0.00073709016089703 -3.1651157275578 4.06046613880045e-09 MirTarget -0.286102780581204 0.00506815071493037 NA NA NA hsa-miR-331-3p PRKAA2 2.28379581858927 1.99663919173155e-18 -3.1651157275578 4.06046613880045e-09 MirTarget -0.364561950555569 0.000185201672784168 NA NA NA hsa-miR-335-3p PRKAA2 3.08791651139852 5.31309869723517e-12 -3.1651157275578 4.06046613880045e-09 MirTarget -0.217607069917347 0.000151452265177902 NA NA NA hsa-miR-335-5p PRKAA2 1.77247705492746 2.22457658872091e-06 -3.1651157275578 4.06046613880045e-09 MirTarget;miRNATAP -0.189757321047362 0.00673896582128403 NA NA NA hsa-miR-33a-3p PRKAA2 1.72765312072219 1.51784443453521e-07 -3.1651157275578 4.06046613880045e-09 mirMAP -0.197716151311991 0.0240888641750769 NA NA NA hsa-miR-342-3p PRKAA2 1.49115144672245 1.43879249744621e-07 -3.1651157275578 4.06046613880045e-09 PITA -0.365301673219482 7.27987168209179e-05 NA NA NA hsa-miR-34a-5p PRKAA2 1.9016323452565 1.43092834643601e-14 -3.1651157275578 4.06046613880045e-09 miRNATAP -0.697992393841294 7.93258270698692e-12 NA NA NA hsa-miR-374a-3p PRKAA2 0.533309330504947 0.00192918429705142 -3.1651157275578 4.06046613880045e-09 mirMAP -0.468265324710388 0.0026860278599259 NA NA NA hsa-miR-429 PRKAA2 4.48815175680773 2.44117492218206e-17 -3.1651157275578 4.06046613880045e-09 MirTarget;miRNATAP -0.234368381119893 8.26598458529829e-07 NA NA NA hsa-miR-454-3p PRKAA2 2.47234127820054 1.12878018736016e-21 -3.1651157275578 4.06046613880045e-09 MirTarget -0.516124002344748 2.14118798191959e-07 NA NA NA hsa-miR-500a-5p PRKAA2 1.72110365584658 3.0807246212659e-10 -3.1651157275578 4.06046613880045e-09 mirMAP -0.291639409971857 0.00221883780805263 NA NA NA hsa-miR-576-5p PRKAA2 2.20467023993664 3.4053475193793e-19 -3.1651157275578 4.06046613880045e-09 mirMAP -0.576206223473929 1.6711936398277e-08 NA NA NA hsa-miR-582-5p PRKAA2 0.609226359812689 0.032988717891497 -3.1651157275578 4.06046613880045e-09 mirMAP -0.270459108094453 0.00363606827304358 NA NA NA hsa-miR-589-5p PRKAA2 1.71990116752371 8.310889042056e-14 -3.1651157275578 4.06046613880045e-09 MirTarget -0.376078241087496 0.00080032835281227 NA NA NA hsa-miR-590-3p PRKAA2 2.59289455139753 1.03200520972022e-21 -3.1651157275578 4.06046613880045e-09 mirMAP;miRNATAP -0.430999919941564 6.04499840743536e-06 NA NA NA hsa-miR-664a-3p PRKAA2 0.634721925861133 0.00520070178640421 -3.1651157275578 4.06046613880045e-09 MirTarget -0.510084786462165 1.19979296115228e-05 NA NA NA hsa-miR-7-1-3p PRKAA2 1.84950311431067 1.25300363397654e-13 -3.1651157275578 4.06046613880045e-09 MirTarget;mirMAP -0.360511833799086 0.000488208563484811 NA NA NA hsa-miR-93-5p PRKAA2 3.03961860136032 1.11672209617395e-24 -3.1651157275578 4.06046613880045e-09 mirMAP -0.360317996321163 1.81157969199634e-05 NA NA NA hsa-miR-944 PRKAA2 2.91186649218281 1.31574753528144e-06 -3.1651157275578 4.06046613880045e-09 mirMAP -0.304599294327695 3.71005202161829e-12 NA NA NA hsa-miR-96-5p PRKAA2 4.89433085814374 1.92000659886961e-31 -3.1651157275578 4.06046613880045e-09 TargetScan -0.301126902372243 4.20848274807667e-07 NA NA NA hsa-miR-98-5p PRKAA2 1.11154309866014 1.24143909012085e-08 -3.1651157275578 4.06046613880045e-09 miRNAWalker2_validate;MirTarget -0.364025165304353 0.00705071490635534 NA NA NA hsa-miR-125a-5p PRKAR2A 0.599529391575274 0.0102300147180307 -0.958058230501873 0.00166358416501506 miRanda -0.37787946708526 1.5675108729139e-09 NA NA NA hsa-miR-125a-5p PROS1 0.599529391575274 0.0102300147180307 -1.686295066647 7.9246547096002e-08 miRanda -0.274904595787613 3.09778285261208e-05 NA NA NA hsa-miR-125a-5p PROX1 0.599529391575274 0.0102300147180307 -2.49034953093375 1.14921276053561e-06 miRanda -0.232455079630751 0.0315295354139882 NA NA NA hsa-miR-125a-5p PRSS35 0.599529391575274 0.0102300147180307 -2.80054515679956 8.39094108590233e-09 MirTarget;PITA;miRanda -0.267655009720107 0.00942506527919927 NA NA NA hsa-miR-125a-5p PSAPL1 0.599529391575274 0.0102300147180307 0.498276295635988 0.526007397293778 miRanda -0.475716136185842 0.00358263844456392 NA NA NA hsa-miR-125a-5p PSMB8 0.599529391575274 0.0102300147180307 0.596466808982245 0.0221622814392124 MirTarget;miRanda;miRNATAP -0.120186605842873 0.0271564834281883 NA NA NA hsa-miR-125a-5p PSMB9 0.599529391575274 0.0102300147180307 0.508848732812598 0.224399727423064 miRanda -0.407495503344495 2.38298630656103e-06 NA NA NA hsa-miR-125a-5p PTAR1 0.599529391575274 0.0102300147180307 -0.472407700260961 0.00283595748436887 PITA -0.160175748315502 9.27155667442146e-07 NA NA NA hsa-miR-125a-5p PTGER3 0.599529391575274 0.0102300147180307 -3.17892614473001 1.0932904794636e-07 miRanda -0.640234524637115 3.12010664657599e-07 NA NA NA hsa-miR-125a-5p PTPRD 0.599529391575274 0.0102300147180307 -3.62979486144354 1.88740064210481e-09 miRanda -0.361587707209681 0.00481861546449697 NA NA NA hsa-miR-125a-5p PTPRJ 0.599529391575274 0.0102300147180307 -0.171140377199757 0.522786552038373 miRanda -0.241606769729852 1.22673567789148e-05 NA NA NA hsa-miR-125a-5p PYHIN1 0.599529391575274 0.0102300147180307 -1.22107679211918 0.0171839165741657 miRanda -0.500848648778661 2.27890920140375e-06 NA NA NA hsa-miR-125a-5p QSOX2 0.599529391575274 0.0102300147180307 0.649040604358276 0.000287219161922959 miRNATAP -0.156010232370932 2.71513133692272e-05 NA NA NA hsa-miR-125a-5p RAB11FIP5 0.599529391575274 0.0102300147180307 -0.275218903695492 0.0980214449037859 miRanda -0.163495133432028 1.77762086533713e-06 NA NA NA hsa-miR-125a-5p RAB33A 0.599529391575274 0.0102300147180307 -0.757980988096248 0.0172580900095732 miRanda -0.270943027562696 4.03154733576608e-05 NA NA NA hsa-miR-125a-5p RAB37 0.599529391575274 0.0102300147180307 -2.48418953088763 5.0734045898238e-12 miRanda;mirMAP -0.296756079565137 0.000105958644293748 NA NA NA hsa-miR-125a-5p RABGAP1 0.599529391575274 0.0102300147180307 -0.773246435624024 3.15867332544188e-09 miRanda -0.118855055460545 1.42609722447092e-05 NA NA NA hsa-miR-125a-5p RABGAP1L 0.599529391575274 0.0102300147180307 -0.473108720080822 0.0208776609095607 miRanda -0.196651272722988 3.29284705092627e-06 NA NA NA hsa-miR-125a-5p RACGAP1 0.599529391575274 0.0102300147180307 1.48568326123243 4.08465090073292e-11 miRanda -0.286496988853764 1.18816162373028e-09 NA NA NA hsa-miR-125a-5p RAD23B 0.599529391575274 0.0102300147180307 0.0950269555852143 0.477851118135714 miRanda -0.161557049485339 3.10909222712437e-09 NA NA NA hsa-miR-125a-5p RAP1A 0.599529391575274 0.0102300147180307 -1.0434884652411 1.94863584356979e-14 miRanda -0.120822313738346 3.16483745923974e-05 NA NA NA hsa-miR-125a-5p RAPGEF5 0.599529391575274 0.0102300147180307 -0.580986175597244 0.0366906480299328 MirTarget;PITA;miRanda -0.378402896092275 2.42015984659798e-11 NA NA NA hsa-miR-125a-5p RASAL1 0.599529391575274 0.0102300147180307 2.73083818834237 5.01884098334534e-06 miRanda -0.25172998131406 0.0460575287306445 NA NA NA hsa-miR-125a-5p RASD2 0.599529391575274 0.0102300147180307 -1.12997429321381 0.00368794992869921 miRanda;mirMAP -0.212629092700778 0.00892193738483081 NA NA NA hsa-miR-125a-5p RASSF8 0.599529391575274 0.0102300147180307 -1.48887021923134 4.62579164697906e-06 miRanda -0.324275856912628 1.69696845324165e-06 NA NA NA hsa-miR-125a-5p RBBP5 0.599529391575274 0.0102300147180307 -0.0407971654854768 0.828836272281405 miRanda -0.239691557638273 4.44525762757728e-10 NA NA NA hsa-miR-125a-5p RBM20 0.599529391575274 0.0102300147180307 -2.46227191748389 1.31938346873951e-07 MirTarget;miRanda -0.293075617673667 0.00293378672782964 NA NA NA hsa-miR-125a-5p RBM41 0.599529391575274 0.0102300147180307 0.334365358372572 0.0347137820734355 miRanda -0.120841780572713 0.000227172490447832 NA NA NA hsa-miR-125a-5p RBM7 0.599529391575274 0.0102300147180307 -0.635938038315606 2.10598323164864e-05 MirTarget;PITA;miRanda;miRNATAP -0.172220933953031 2.41541166035326e-08 NA NA NA hsa-miR-125a-5p RCAN1 0.599529391575274 0.0102300147180307 -2.15647288077041 5.50992507009283e-16 miRanda -0.286186683134339 4.80923825532392e-07 NA NA NA hsa-miR-125a-5p REEP2 0.599529391575274 0.0102300147180307 -2.28234806088443 5.83937284635847e-08 mirMAP -0.377487030881688 1.9638908698259e-05 NA NA NA hsa-miR-125a-5p REST 0.599529391575274 0.0102300147180307 -0.509917606171453 0.126822367219067 MirTarget -0.229682652136995 0.00092646740061838 NA NA NA hsa-miR-125a-5p RET 0.599529391575274 0.0102300147180307 -0.845706703693476 0.0349656102167993 PITA;miRanda -0.244102442748386 0.00346934818702249 NA NA NA hsa-miR-125a-5p RFX5 0.599529391575274 0.0102300147180307 0.103717560050109 0.480044373242283 miRNATAP -0.119421641697328 8.00299810177711e-05 NA NA NA hsa-miR-125a-5p RGMB 0.599529391575274 0.0102300147180307 -0.652881684524727 1.24724355373277e-05 miRanda -0.101071578436272 0.00121773894103221 NA NA NA hsa-miR-125a-5p RHBDL3 0.599529391575274 0.0102300147180307 -2.21076712333666 1.54452647440133e-05 mirMAP -0.347721708590038 0.00119395783469224 NA NA NA hsa-miR-125a-5p RHOJ 0.599529391575274 0.0102300147180307 -2.30772881830049 1.21996505858213e-14 miRanda -0.128902437486762 0.045601024674369 NA NA NA hsa-let-7i-5p RICTOR 0.412877696970403 0.00622731051981756 -0.0636558558251128 0.690801456304219 MirTarget;miRNATAP -0.181498389332032 0.000474512978277903 NA NA NA hsa-miR-139-5p RICTOR -1.52606598644743 1.20474151350665e-08 -0.0636558558251128 0.690801456304219 MirTarget;PITA;miRanda -0.117309140283128 3.26793845059091e-05 NA NA NA hsa-miR-140-3p RICTOR 0.0608890720479334 0.727716871248724 -0.0636558558251128 0.690801456304219 MirTarget;PITA;miRNATAP -0.139944872162773 0.00177546724259963 NA NA NA hsa-miR-218-5p RICTOR -0.573801507392184 0.0551983860126703 -0.0636558558251128 0.690801456304219 miRNAWalker2_validate;miRTarBase;miRNATAP -0.128099349308607 5.27766413859692e-07 NA NA NA hsa-miR-495-3p RICTOR -0.0847115949846082 0.763475496144456 -0.0636558558251128 0.690801456304219 MirTarget -0.143309782555465 1.46249599436837e-07 NA NA NA hsa-miR-497-5p RICTOR 0.0257087130056286 0.918145413833358 -0.0636558558251128 0.690801456304219 MirTarget;miRNATAP -0.107838893771902 0.000492230040753755 NA NA NA hsa-miR-660-5p RICTOR 1.82692095272076 1.92040083607196e-13 -0.0636558558251128 0.690801456304219 MirTarget -0.125254027693193 3.16011915894253e-05 NA NA NA hsa-miR-125a-5p RIF1 0.599529391575274 0.0102300147180307 -0.258348346049693 0.259725210292338 miRanda -0.302872951768046 8.54586498581581e-11 NA NA NA hsa-miR-125a-5p RIMKLB 0.599529391575274 0.0102300147180307 -0.825833788774339 0.00780804620647977 miRanda -0.344955999518811 6.86967639153345e-08 NA NA NA hsa-miR-125a-5p RIMS3 0.599529391575274 0.0102300147180307 -1.42027619315578 3.00440701262036e-05 mirMAP -0.409813418936275 5.6829647454937e-09 NA NA NA hsa-miR-125a-5p RIN3 0.599529391575274 0.0102300147180307 -0.542708773196135 0.0113680652033468 miRanda;mirMAP -0.186657646485646 2.62315240079526e-05 NA NA NA hsa-miR-125a-5p RNF141 0.599529391575274 0.0102300147180307 -0.655565071226112 5.10180275924176e-05 miRanda -0.131658776305236 9.39864885402163e-05 NA NA NA hsa-miR-125a-5p RNF144B 0.599529391575274 0.0102300147180307 0.484234841326764 0.109182210482914 miRanda -0.240499356278484 0.000122906447981 NA NA NA hsa-miR-125a-5p RNF168 0.599529391575274 0.0102300147180307 -0.445857747815915 0.0839743141418269 MirTarget -0.293378811416538 3.00657471658573e-08 NA NA NA hsa-miR-125a-5p RNF180 0.599529391575274 0.0102300147180307 -2.77234880605368 2.71970344654215e-14 miRanda -0.237438009714161 0.00240172733322516 NA NA NA hsa-miR-125a-5p RNF216 0.599529391575274 0.0102300147180307 -0.284209271050796 0.0177325861546712 mirMAP -0.161162018432707 3.47640649919655e-11 NA NA NA hsa-miR-125a-5p RNF26 0.599529391575274 0.0102300147180307 0.36816975914411 0.00804898188509874 miRanda -0.101735504790163 0.000410087173113312 NA NA NA hsa-miR-125a-5p RPLP0P2 0.599529391575274 0.0102300147180307 1.94646218347448 1.77010350359014e-07 miRanda -0.212148786956876 0.00704214726575427 NA NA NA hsa-miR-125b-5p RPS6KA1 -1.16462950151259 0.000288900271798384 1.34988540411024 1.15370611659724e-11 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.13692356644705 6.2422468067932e-06 NA NA NA hsa-miR-139-5p RPS6KA1 -1.52606598644743 1.20474151350665e-08 1.34988540411024 1.15370611659724e-11 miRanda -0.104159748301514 0.00411281450359946 NA NA NA hsa-let-7g-3p RPS6KA2 3.26398061402445 3.96263126107645e-25 -1.89918037721253 3.87074381310148e-13 MirTarget -0.246721753553459 3.41630640648566e-10 NA NA NA hsa-miR-1271-5p RPS6KA2 0.970418832993172 0.000609742584380688 -1.89918037721253 3.87074381310148e-13 mirMAP -0.20251993530887 9.27638787048565e-06 NA NA NA hsa-miR-130b-5p RPS6KA2 2.9963110846538 1.98883029416455e-18 -1.89918037721253 3.87074381310148e-13 mirMAP -0.235363829031829 1.54980286279085e-10 NA NA NA hsa-miR-17-5p RPS6KA2 3.2710598467455 9.93128340539455e-27 -1.89918037721253 3.87074381310148e-13 TargetScan -0.308938986160142 1.53086675306477e-15 NA NA NA hsa-miR-181a-2-3p RPS6KA2 2.19062681262366 3.81790102612782e-13 -1.89918037721253 3.87074381310148e-13 mirMAP -0.185814296672575 8.43603766197703e-06 NA NA NA hsa-miR-185-3p RPS6KA2 2.3922478518806 1.3373426768452e-14 -1.89918037721253 3.87074381310148e-13 MirTarget -0.23896304263491 2.26811072773796e-09 NA NA NA hsa-miR-193a-3p RPS6KA2 1.60460546928078 2.86169793322984e-07 -1.89918037721253 3.87074381310148e-13 mirMAP -0.182027317307988 8.38861562840483e-06 NA NA NA hsa-miR-193b-3p RPS6KA2 2.25711804611899 4.1940744806631e-14 -1.89918037721253 3.87074381310148e-13 mirMAP -0.311500359089077 3.53991075205589e-14 NA NA NA hsa-miR-19a-3p RPS6KA2 3.42309334186656 3.02671914353412e-28 -1.89918037721253 3.87074381310148e-13 MirTarget -0.274673751333933 6.75653405295878e-13 NA NA NA hsa-miR-19b-3p RPS6KA2 2.49529833021187 1.57028265846699e-23 -1.89918037721253 3.87074381310148e-13 MirTarget -0.319321802710713 4.74464788644084e-11 NA NA NA hsa-miR-200c-3p RPS6KA2 3.50132673580082 2.42716349086937e-15 -1.89918037721253 3.87074381310148e-13 miRNATAP -0.129334089352011 4.4517289901593e-06 NA NA NA hsa-miR-21-3p RPS6KA2 2.19296355304364 4.63665722759779e-15 -1.89918037721253 3.87074381310148e-13 MirTarget -0.272784541769791 7.52288789174635e-10 NA NA NA hsa-miR-26b-5p RPS6KA2 0.885393662798425 3.2116297961629e-06 -1.89918037721253 3.87074381310148e-13 miRNATAP -0.227177310507267 0.000899668091721707 NA NA NA hsa-miR-3065-5p RPS6KA2 2.74629919868982 1.86846589298284e-08 -1.89918037721253 3.87074381310148e-13 mirMAP -0.129392772331137 5.16506987695122e-05 NA NA NA hsa-miR-30e-5p RPS6KA2 1.23904909539663 1.35561917122157e-09 -1.89918037721253 3.87074381310148e-13 MirTarget -0.167397027801108 0.00795729353132801 NA NA NA hsa-miR-3127-5p RPS6KA2 1.51846438737133 3.59571251672767e-07 -1.89918037721253 3.87074381310148e-13 mirMAP -0.13587142025251 0.00161943122406181 NA NA NA hsa-miR-532-3p RPS6KA2 1.96631878320218 4.53421954361695e-13 -1.89918037721253 3.87074381310148e-13 MirTarget;mirMAP -0.217249391578203 2.76835498444362e-06 NA NA NA hsa-miR-589-5p RPS6KA2 1.71990116752371 8.310889042056e-14 -1.89918037721253 3.87074381310148e-13 mirMAP -0.333681503852927 7.42768576140755e-10 NA NA NA hsa-miR-93-3p RPS6KA2 2.85383869771942 5.64481766902125e-23 -1.89918037721253 3.87074381310148e-13 MirTarget -0.236183258286661 2.11710105875058e-08 NA NA NA hsa-let-7d-5p RPS6KA3 1.33236798905207 1.1741085658466e-13 -0.370806818018999 0.0220707753218686 miRNATAP -0.114489938702704 0.00756705340948625 NA NA NA hsa-miR-136-5p RPS6KA3 2.09637138292451 1.50140005592201e-10 -0.370806818018999 0.0220707753218686 mirMAP -0.117791568961288 3.67256904611671e-07 NA NA NA hsa-miR-181a-5p RPS6KA3 2.29556023480783 1.8138457900616e-21 -0.370806818018999 0.0220707753218686 MirTarget;mirMAP;miRNATAP -0.121039283729606 8.78983023529811e-05 NA NA NA hsa-miR-181c-5p RPS6KA3 1.58587920618301 1.57506918816933e-10 -0.370806818018999 0.0220707753218686 MirTarget;mirMAP;miRNATAP -0.137925322197845 7.60328156936309e-06 NA NA NA hsa-miR-186-5p RPS6KA3 1.47445398888668 3.0781726595413e-15 -0.370806818018999 0.0220707753218686 MirTarget;mirMAP;miRNATAP -0.111734638474146 0.00635139835787659 NA NA NA hsa-miR-21-5p RPS6KA3 2.73773305747971 1.38864982139576e-43 -0.370806818018999 0.0220707753218686 miRNAWalker2_validate;mirMAP;miRNATAP -0.115651579127679 0.00124546897217506 NA NA NA hsa-miR-320a RPS6KA3 0.438165828017084 0.0390159073347133 -0.370806818018999 0.0220707753218686 miRNAWalker2_validate;miRanda -0.105734074591902 0.00443346974555563 NA NA NA hsa-miR-1271-5p RPS6KA6 0.970418832993172 0.000609742584380688 -0.643070571271251 0.264542356112038 MirTarget -0.28783551839478 0.00344430588607334 NA NA NA hsa-miR-199a-3p RPS6KA6 0.640600337515787 0.0380326905134914 -0.643070571271251 0.264542356112038 MirTarget -0.494218120175028 2.93790214049553e-08 NA NA NA hsa-miR-199b-3p RPS6KA6 0.643923492750702 0.0371742251925406 -0.643070571271251 0.264542356112038 MirTarget -0.493553319945077 2.99976098785352e-08 NA NA NA hsa-miR-217 RPS6KA6 0.608024397387488 0.199352491710517 -0.643070571271251 0.264542356112038 miRanda -0.218929391103907 0.000280286435780485 NA NA NA hsa-miR-338-5p RPS6KA6 -0.577691606146419 0.0472212680542825 -0.643070571271251 0.264542356112038 MirTarget -0.211094505598065 0.0294237857264803 NA NA NA hsa-miR-424-5p RPS6KA6 1.61930224569578 1.89642549274994e-10 -0.643070571271251 0.264542356112038 MirTarget -0.275006218909343 0.0107505875800356 NA NA NA hsa-miR-655-3p RPS6KA6 0.485339318272148 0.137014658258732 -0.643070571271251 0.264542356112038 MirTarget -0.294210829929277 0.000704709579255314 NA NA NA hsa-miR-708-3p RPS6KA6 2.80907765282502 3.07460722669281e-14 -0.643070571271251 0.264542356112038 MirTarget -0.173132616422874 0.017829398044062 NA NA NA hsa-miR-125a-5p RREB1 0.599529391575274 0.0102300147180307 -0.0343520581391097 0.863011785829249 miRanda -0.134074364845311 0.00114757815536763 NA NA NA hsa-miR-125a-5p RRM2 0.599529391575274 0.0102300147180307 3.09406037621288 4.77730173839214e-23 miRanda -0.232721746714457 0.000699122664729244 NA NA NA hsa-miR-125a-5p RUSC2 0.599529391575274 0.0102300147180307 -1.59852075923141 8.04308093421491e-11 PITA;miRanda;miRNATAP -0.221247607543767 2.10956003442017e-05 NA NA NA hsa-miR-125a-5p RYR2 0.599529391575274 0.0102300147180307 -3.05265921395896 1.45778696980797e-09 miRanda -0.436572004145634 4.21095884254018e-05 NA NA NA hsa-miR-125a-5p SAMD4A 0.599529391575274 0.0102300147180307 -2.17607774370782 7.9670339471712e-12 miRanda -0.239484777846509 0.000407428624393156 NA NA NA hsa-miR-125a-5p SBNO1 0.599529391575274 0.0102300147180307 -0.431799058649128 0.176307680352389 MirTarget -0.297474879987972 6.39071169843586e-06 NA NA NA hsa-miR-125a-5p SCAPER 0.599529391575274 0.0102300147180307 -1.06415475815357 4.56655552943022e-09 miRanda -0.158215073308626 3.44229245262782e-05 NA NA NA hsa-miR-125a-5p SCML2 0.599529391575274 0.0102300147180307 -0.950080740895381 0.0546941084335224 miRanda -0.572914071696471 1.68484408661747e-08 NA NA NA hsa-miR-125a-5p SCN2B 0.599529391575274 0.0102300147180307 -4.29366513636715 3.96960287530702e-15 PITA;miRanda;mirMAP -0.630253497808084 5.95286992340047e-08 NA NA NA hsa-miR-125a-5p SEC14L2 0.599529391575274 0.0102300147180307 1.19539470031568 0.000234070169376389 MirTarget;miRanda;mirMAP -0.14629856658415 0.0318558216360919 NA NA NA hsa-miR-125a-5p SET 0.599529391575274 0.0102300147180307 0.186243353896371 0.126940244726896 PITA;miRanda -0.127199139850885 3.55805739361071e-07 NA NA NA hsa-miR-125a-5p SFRP5 0.599529391575274 0.0102300147180307 -4.00418767619732 1.33283270821635e-12 miRanda -0.256106973996982 0.0344648542704912 NA NA NA hsa-miR-125a-5p SH2D5 0.599529391575274 0.0102300147180307 1.42417220789769 0.0115205192600078 miRanda -0.684948153906647 3.25758919423493e-09 NA NA NA hsa-miR-125a-5p SH3BP4 0.599529391575274 0.0102300147180307 -0.101791437134307 0.706865136484442 PITA;miRanda;miRNATAP -0.216329834829464 0.000111200907532417 NA NA NA hsa-miR-125a-5p SIGLEC7 0.599529391575274 0.0102300147180307 0.0704733308186464 0.878992176411201 miRanda -0.492905245809596 2.20044036392612e-07 NA NA NA hsa-miR-125a-5p SIGLEC8 0.599529391575274 0.0102300147180307 -1.85927212216011 0.000249795909554409 miRanda -0.241105520605259 0.0236009968867574 NA NA NA hsa-miR-125a-5p SIK2 0.599529391575274 0.0102300147180307 -0.895905910195029 1.03810013473188e-10 mirMAP -0.13179230053253 6.34560106323494e-06 NA NA NA hsa-miR-125a-5p SIT1 0.599529391575274 0.0102300147180307 -0.74669479532674 0.15001839260191 miRanda -0.518020752043835 1.27627998448093e-06 NA NA NA hsa-miR-125a-5p SLA2 0.599529391575274 0.0102300147180307 -0.565669168348206 0.207321992430639 miRanda -0.473054333349123 2.97705117085411e-07 NA NA NA hsa-miR-125a-5p SLC11A1 0.599529391575274 0.0102300147180307 0.867908057685686 0.0131292136384068 miRanda;mirMAP -0.184457292822469 0.011540358319718 NA NA NA hsa-miR-125a-5p SLC30A8 0.599529391575274 0.0102300147180307 -2.88971596996447 3.20345577865474e-07 miRanda -0.404183797915281 0.000687665653488637 NA NA NA hsa-miR-125a-5p SLC38A7 0.599529391575274 0.0102300147180307 1.0495296510055 1.70436261268652e-08 mirMAP -0.161332446193031 3.70432343632476e-05 NA NA NA hsa-miR-125a-5p SLC39A8 0.599529391575274 0.0102300147180307 0.248276675119964 0.380319177862353 miRanda -0.291494776620204 5.49397110495907e-07 NA NA NA hsa-miR-125a-5p SLC46A3 0.599529391575274 0.0102300147180307 -0.583906818008395 0.0453582675629221 MirTarget;miRanda -0.157203604644031 0.00969740368601473 NA NA NA hsa-miR-125a-5p SLC4A8 0.599529391575274 0.0102300147180307 -0.0859657189548841 0.821662144114553 PITA;miRanda -0.320773814874643 4.7258869368384e-05 NA NA NA hsa-miR-125a-5p SLC6A15 0.599529391575274 0.0102300147180307 -1.96696832929733 0.00992022442947405 miRanda -1.22561998230364 1.8252258916705e-15 NA NA NA hsa-miR-125a-5p SLC6A17 0.599529391575274 0.0102300147180307 0.941104200796897 0.0568131902197341 PITA -0.602465038450026 2.67737712749896e-09 NA NA NA hsa-miR-125a-5p SLC7A1 0.599529391575274 0.0102300147180307 0.0553385590912683 0.83891351896488 MirTarget;miRanda -0.384054623372915 3.4647690418486e-12 NA NA NA hsa-miR-125a-5p SLCO1A2 0.599529391575274 0.0102300147180307 1.87919500268659 0.0187581580576033 miRanda -0.399712545944177 0.0166624245925785 NA NA NA hsa-miR-125a-5p SLCO2B1 0.599529391575274 0.0102300147180307 -0.857147486993845 0.0465370602382169 mirMAP -0.453451149428205 3.21800487161042e-07 NA NA NA hsa-miR-125a-5p SLFN11 0.599529391575274 0.0102300147180307 -0.526738853438438 0.153699831151944 miRNAWalker2_validate -0.449634181440328 2.68576318976256e-09 NA NA NA hsa-miR-125a-5p SMC2 0.599529391575274 0.0102300147180307 0.659262934368868 0.00208551147620892 miRanda -0.328382284616255 3.95787641034421e-14 NA NA NA hsa-miR-125a-5p SMCR8 0.599529391575274 0.0102300147180307 -0.202130894267996 0.227726090781436 MirTarget -0.194899222323735 1.27894316434059e-08 NA NA NA hsa-miR-125a-5p SOCS4 0.599529391575274 0.0102300147180307 -0.3499734105495 0.00323916823545163 PITA;miRanda;miRNATAP -0.119458667885022 1.03277082484478e-06 NA NA NA hsa-miR-125a-5p SOD2 0.599529391575274 0.0102300147180307 -0.967382789820389 0.000741784113575493 miRanda -0.362643291112579 7.42866469729495e-10 NA NA NA hsa-miR-125a-5p SOX30 0.599529391575274 0.0102300147180307 -1.02616068855759 0.0156494506347111 PITA;miRanda -0.500669358561471 9.49299415212035e-09 NA NA NA hsa-miR-125a-5p SP3 0.599529391575274 0.0102300147180307 -0.148382470380955 0.279714682392886 miRanda -0.110014650433023 0.000101371809800964 NA NA NA hsa-miR-125a-5p SP5 0.599529391575274 0.0102300147180307 -1.73359652512303 0.00400326090199408 miRanda -0.394367138427522 0.00170056645775916 NA NA NA hsa-miR-125a-5p SPEG 0.599529391575274 0.0102300147180307 -3.3963864959642 1.20357219423433e-09 MirTarget;miRanda;miRNATAP -0.58069725761371 7.72880506923697e-07 NA NA NA hsa-miR-125a-5p SRF 0.599529391575274 0.0102300147180307 -1.54762802860391 1.84904741152095e-30 mirMAP -0.13579699660111 5.58208979872605e-06 NA NA NA hsa-miR-125a-5p SRGAP1 0.599529391575274 0.0102300147180307 0.0862407503716072 0.687781344054672 miRanda -0.165778559843139 0.000186976004790562 NA NA NA hsa-miR-125a-5p ST6GAL1 0.599529391575274 0.0102300147180307 -0.974311482157085 0.00681003647045031 MirTarget;miRanda;miRNATAP -0.236320301533612 0.00163637227557272 NA NA NA hsa-miR-125a-5p ST8SIA4 0.599529391575274 0.0102300147180307 -0.0167304429257027 0.953663620918297 PITA;miRanda -0.256577497351633 1.57259587048031e-05 NA NA NA hsa-miR-125a-5p STARD13 0.599529391575274 0.0102300147180307 -2.17932975894295 1.5776545031728e-14 PITA;miRanda;miRNATAP -0.175765304750945 0.00394378164528527 NA NA NA hsa-miR-125a-5p STAT3 0.599529391575274 0.0102300147180307 -0.539456513473352 0.0002104451396002 PITA;miRanda -0.229908411174338 5.88632762561847e-15 26389681;26878391 MiR 125a suppresses tumor growth invasion and metastasis in cervical cancer by targeting STAT3; Dual luciferase assays identified the STAT3 gene as a novel direct target of miR-125a; Functional studies showed that miR-125a overexpression significantly suppressed the growth invasion and epithelial-mesenchymal transition EMT of cervical cancer cells both in vitro and in vivo via decreasing STAT3 expression; Clinically STAT3 the expression of which predicted poorer outcome was inversely correlated with miR-125a in cervical cancer;MiR 125a promotes paclitaxel sensitivity in cervical cancer through altering STAT3 expression; Moreover we determined that miR-125a increased paclitaxel and cisplatin sensitivity by downregulating STAT3 metastasis; cervical and endocervical cancer;cervical and endocervical cancer hsa-miR-125a-5p STAT4 0.599529391575274 0.0102300147180307 -0.54405037149823 0.200971233130196 miRanda -0.439351239984822 5.28353047056891e-07 NA NA NA hsa-miR-125a-5p STC1 0.599529391575274 0.0102300147180307 -1.55340441030689 1.29077994156941e-05 PITA;miRanda -0.163849257357535 0.0288342138654642 NA NA NA hsa-miR-125a-5p STC2 0.599529391575274 0.0102300147180307 0.0607396741361685 0.863877937094139 miRanda -0.275740869128535 0.00016988957596706 NA NA NA hsa-miR-125a-5p STK3 0.599529391575274 0.0102300147180307 0.157754074583901 0.310254102765732 miRanda -0.13587832062123 2.21374644392661e-05 NA NA NA hsa-miR-125a-5p STK32B 0.599529391575274 0.0102300147180307 -2.61396331973719 1.54503278061385e-11 miRanda -0.342876584063141 3.06340633885273e-05 NA NA NA hsa-miR-125a-5p STK40 0.599529391575274 0.0102300147180307 -1.26400207575733 1.00508386470648e-16 mirMAP -0.119554675885335 0.000258100364292847 NA NA NA hsa-miR-125a-5p STMN3 0.599529391575274 0.0102300147180307 -1.01921953587904 0.00577967990973407 miRNATAP -0.233501550952894 0.00242827224994639 NA NA NA hsa-miR-125a-5p STOX2 0.599529391575274 0.0102300147180307 -1.03419792881613 0.00367103026717332 miRanda -0.174908046755024 0.0187773953335028 NA NA NA hsa-miR-125a-5p STX17 0.599529391575274 0.0102300147180307 -0.343981391742685 0.00166799096480426 MirTarget -0.117146525700859 1.81641384232955e-07 NA NA NA hsa-miR-125a-5p SYNPO 0.599529391575274 0.0102300147180307 -1.74025803466879 1.56969745033557e-11 miRanda -0.228500059021965 2.98500434718191e-05 NA NA NA hsa-miR-125a-5p SYT14 0.599529391575274 0.0102300147180307 1.12770103794047 0.0806401427451292 miRanda -0.385267681042192 0.00414627719233452 NA NA NA hsa-miR-125a-5p TAF4B 0.599529391575274 0.0102300147180307 -0.440551340182907 0.163919692677726 miRanda -0.496643922261851 7.11396155161707e-15 NA NA NA hsa-miR-125a-5p TAP2 0.599529391575274 0.0102300147180307 0.864052289548255 0.00137646168380773 miRanda -0.299050655983558 8.02568772161236e-08 NA NA NA hsa-miR-125a-5p TARSL2 0.599529391575274 0.0102300147180307 -1.16655204108317 6.59608191425338e-11 miRanda -0.135633243347007 0.000341431640302381 NA NA NA hsa-miR-125a-5p TBC1D13 0.599529391575274 0.0102300147180307 -0.27013948517965 0.0748447873068142 mirMAP -0.110220638712667 0.000444067935255002 NA NA NA hsa-miR-125a-5p TBC1D16 0.599529391575274 0.0102300147180307 -0.000723386575430585 0.997052256137848 MirTarget;mirMAP -0.186953174478081 3.47461482873559e-06 NA NA NA hsa-miR-125a-5p TBC1D24 0.599529391575274 0.0102300147180307 0.507846251639018 0.000638960064492476 mirMAP -0.108042995121085 0.000477548650658867 NA NA NA hsa-miR-125a-5p TBX4 0.599529391575274 0.0102300147180307 -2.74343429126774 1.24165727163166e-06 PITA;miRanda -0.363823658978888 0.00225801126180108 NA NA NA hsa-miR-125a-5p TCF19 0.599529391575274 0.0102300147180307 1.33114266066746 1.65527863675553e-07 miRanda -0.200018386490798 0.000183077922071156 NA NA NA hsa-miR-125a-5p TFRC 0.599529391575274 0.0102300147180307 0.872759930555409 0.000740465082661834 miRNAWalker2_validate -0.149714597641647 0.00562722553008238 NA NA NA hsa-miR-125a-5p THBD 0.599529391575274 0.0102300147180307 -0.731786324641923 0.0859426492175108 miRanda -0.370123033803919 2.71170871336988e-05 NA NA NA hsa-miR-125a-5p TINF2 0.599529391575274 0.0102300147180307 -0.382828717056819 0.000772555448388888 miRanda -0.158724866875012 6.73704583449895e-12 NA NA NA hsa-miR-125a-5p TLN1 0.599529391575274 0.0102300147180307 -1.45515106009239 3.18740725534339e-16 miRanda -0.250388084373335 2.75318186610393e-11 NA NA NA hsa-miR-125a-5p TMC8 0.599529391575274 0.0102300147180307 -0.197765262321771 0.515608596849153 mirMAP -0.147938125673754 0.0194094631500785 NA NA NA hsa-miR-125a-5p TMEM26 0.599529391575274 0.0102300147180307 0.559660236180119 0.0656229565605439 miRanda -0.139632786866048 0.0275886176584684 NA NA NA hsa-miR-125a-5p TMEM63C 0.599529391575274 0.0102300147180307 0.808209141397143 0.155209732021727 miRanda;mirMAP -0.532292672558986 5.83311401278451e-06 NA NA NA hsa-miR-125a-5p TMOD3 0.599529391575274 0.0102300147180307 0.209642477363857 0.214175249528337 miRanda -0.105014293570594 0.0026855945009321 NA NA NA hsa-miR-125a-5p TMPRSS11F 0.599529391575274 0.0102300147180307 -0.0927205150201535 0.858976158034838 miRanda -0.751058319290495 1.25042152843739e-12 NA NA NA hsa-miR-125a-5p TMPRSS13 0.599529391575274 0.0102300147180307 1.35800636243193 0.0240791204697492 miRanda;miRNATAP -0.438447431520255 0.000460577972491037 NA NA NA hsa-miR-125a-5p TNFAIP3 0.599529391575274 0.0102300147180307 -1.62509801593269 1.6029261418853e-06 miRNAWalker2_validate;miRTarBase;miRanda -0.311690818854823 1.08307997815276e-05 NA NA NA hsa-miR-125a-5p TNFAIP8L1 0.599529391575274 0.0102300147180307 0.180733860382186 0.344507663624107 MirTarget;mirMAP -0.253390842065192 7.11674579083327e-11 NA NA NA hsa-miR-125a-5p TNFAIP8L3 0.599529391575274 0.0102300147180307 -3.1328806196616 1.83122109640247e-12 miRanda -0.773816975301007 3.09799000592189e-17 NA NA NA hsa-miR-125a-5p TNFSF4 0.599529391575274 0.0102300147180307 -0.239793737109793 0.545821899301571 PITA;miRanda -0.219022132281048 0.00797009596915407 NA NA NA hsa-miR-125a-5p TOP3A 0.599529391575274 0.0102300147180307 0.480644759404665 0.000735026776320156 miRanda -0.101518610126606 0.000603986012727517 NA NA NA hsa-miR-125a-5p TOR1AIP2 0.599529391575274 0.0102300147180307 0.072912642799817 0.733082833056581 miRNAWalker2_validate -0.167283135309251 0.000153750635120998 NA NA NA hsa-miR-125a-5p TPM4 0.599529391575274 0.0102300147180307 -0.508649568232682 0.00410224160609163 miRNAWalker2_validate -0.125002215662329 0.000690862664113966 NA NA NA hsa-miR-125a-5p TRAK2 0.599529391575274 0.0102300147180307 -1.00416486343596 5.3266660633068e-10 miRanda -0.103826479752845 0.00243481403937816 NA NA NA hsa-miR-125a-5p TRDN 0.599529391575274 0.0102300147180307 -0.702827742218231 0.170417135057388 miRanda -0.296424271507811 0.00545911000070798 NA NA NA hsa-miR-125a-5p TREML2 0.599529391575274 0.0102300147180307 -0.418679032419737 0.361640710729679 mirMAP -0.474598114035887 5.04045986074358e-07 NA NA NA hsa-miR-125a-5p TRIL 0.599529391575274 0.0102300147180307 -1.46802493073098 2.0969564350264e-05 MirTarget;miRanda -0.169816645260185 0.0192606589971314 NA NA NA hsa-miR-125a-5p TRIM14 0.599529391575274 0.0102300147180307 0.602707464106252 0.00419774394269983 MirTarget;PITA;miRanda -0.170824273428445 9.26833681499391e-05 NA NA NA hsa-miR-125a-5p TRIO 0.599529391575274 0.0102300147180307 -0.0784726767491426 0.717034672980817 miRanda -0.206174665574035 3.7411802962973e-06 NA NA NA hsa-miR-125a-5p TRMT5 0.599529391575274 0.0102300147180307 -0.056527372653556 0.638864129328562 miRanda -0.104150338372504 2.56892588321753e-05 NA NA NA hsa-miR-125a-5p TRPM6 0.599529391575274 0.0102300147180307 -1.93538766679862 2.33828833032142e-05 miRanda -0.261043923004611 0.00661155708144839 NA NA NA hsa-miR-125a-5p TRPS1 0.599529391575274 0.0102300147180307 -2.16842073246699 1.62641545265475e-06 MirTarget;PITA;miRanda -0.677174855461152 2.86016273981302e-13 NA NA NA hsa-miR-125a-5p TSHZ3 0.599529391575274 0.0102300147180307 -2.3826164042391 2.29782206551949e-10 miRanda -0.306089895044411 0.000120812364609819 NA NA NA hsa-miR-125a-5p TSLP 0.599529391575274 0.0102300147180307 -2.78747550539602 1.51140552873854e-10 miRanda -0.312152448177977 0.000734800081133321 NA NA NA hsa-miR-125a-5p TSPAN32 0.599529391575274 0.0102300147180307 -1.54895100716109 0.000174381293309628 miRanda -0.216483314900115 0.0123723724949232 NA NA NA hsa-miR-125a-5p TSTD2 0.599529391575274 0.0102300147180307 -0.516810804550806 0.0119137170659462 MirTarget;miRanda;miRNATAP -0.118731660758082 0.00553656482298824 NA NA NA hsa-miR-125a-5p TTC30B 0.599529391575274 0.0102300147180307 0.557070527228309 0.00431248273600184 miRNAWalker2_validate;miRanda -0.116487587159864 0.00417815535473767 NA NA NA hsa-miR-125a-5p TTC7A 0.599529391575274 0.0102300147180307 0.272527108603614 0.160115734215164 miRanda;miRNATAP -0.187599861290981 2.65687833278642e-06 NA NA NA hsa-miR-125a-5p TXNRD1 0.599529391575274 0.0102300147180307 -1.12063019657297 0.000151225388551436 MirTarget;miRanda;miRNATAP -0.431409637230697 9.16207966867187e-13 NA NA NA hsa-miR-125a-5p UAP1L1 0.599529391575274 0.0102300147180307 0.284488426932335 0.274918268554052 mirMAP -0.11509959747026 0.0338574408374318 NA NA NA hsa-miR-125a-5p UBAP1 0.599529391575274 0.0102300147180307 -0.431178405953665 0.00115475828044029 miRanda -0.162626135136253 2.14501950966874e-09 NA NA NA hsa-miR-125a-5p UBE2G1 0.599529391575274 0.0102300147180307 -0.171598848765183 0.168290708440866 MirTarget;PITA;miRanda -0.127157342708578 6.25803211816183e-07 NA NA NA hsa-miR-125a-5p UBQLN2 0.599529391575274 0.0102300147180307 -0.193822070580415 0.162451167209025 miRanda -0.106091369582276 0.000212742984835903 NA NA NA hsa-miR-125a-5p UBR7 0.599529391575274 0.0102300147180307 -0.0916952346609019 0.490033705207256 miRanda -0.157276451228648 6.24911497908774e-09 NA NA NA hsa-miR-125a-5p UCHL5 0.599529391575274 0.0102300147180307 0.372212150456605 0.023784333968762 miRanda -0.191250030581925 1.4371977988709e-08 NA NA NA hsa-miR-26a-5p ULK1 0.0464832722967259 0.752628386912329 0.168631118107132 0.26676283173824 miRNATAP -0.17543741443891 0.000545660569952753 NA NA NA hsa-miR-338-5p ULK1 -0.577691606146419 0.0472212680542825 0.168631118107132 0.26676283173824 PITA -0.136183558809384 5.60724774968058e-08 NA NA NA hsa-let-7d-5p ULK2 1.33236798905207 1.1741085658466e-13 -0.582426572411284 0.00379371000646104 MirTarget -0.111425190965775 0.0372609723503154 NA NA NA hsa-let-7e-5p ULK2 0.860104282510173 6.04758298373779e-05 -0.582426572411284 0.00379371000646104 MirTarget -0.106151678752928 0.0198281047608298 NA NA NA hsa-let-7f-1-3p ULK2 1.55054488387679 7.31326775537952e-11 -0.582426572411284 0.00379371000646104 MirTarget -0.125305835260512 0.00247463325840322 NA NA NA hsa-let-7g-5p ULK2 1.20061455355116 1.50237505511483e-12 -0.582426572411284 0.00379371000646104 MirTarget -0.165050528466831 0.00363550241375785 NA NA NA hsa-let-7i-5p ULK2 0.412877696970403 0.00622731051981756 -0.582426572411284 0.00379371000646104 MirTarget -0.172181963679009 0.00898713806249386 NA NA NA hsa-miR-140-5p ULK2 0.844753502512594 3.73722278438606e-05 -0.582426572411284 0.00379371000646104 miRanda -0.184727637468753 9.90523092823506e-05 NA NA NA hsa-miR-186-5p ULK2 1.47445398888668 3.0781726595413e-15 -0.582426572411284 0.00379371000646104 MirTarget -0.157734543365668 0.00196013457709713 NA NA NA hsa-miR-22-3p ULK2 1.21545661147757 1.61670170137775e-13 -0.582426572411284 0.00379371000646104 MirTarget -0.16192209246504 0.00556684151656764 NA NA NA hsa-miR-26a-5p ULK2 0.0464832722967259 0.752628386912329 -0.582426572411284 0.00379371000646104 MirTarget -0.137064696597495 0.0436845224449156 NA NA NA hsa-miR-26b-5p ULK2 0.885393662798425 3.2116297961629e-06 -0.582426572411284 0.00379371000646104 MirTarget -0.240421415650889 2.31215037237229e-06 26920049 MiR 26b inhibits autophagy by targeting ULK2 in prostate cancer cells; We found that miR-26b inhibited autophagy in PC-3 and C4-2 cells through down-regulation of ULK2 expression; Dual luciferase reporter assays showed that miR-26b binds the 3'UTR of ULK2 suggesting that ULK2 is a direct target of miR-26b; Real-time PCR and Western blot analysis confirmed that over-expression of miR-26b reduced ULK2 mRNA and protein levels; Taken together our findings indicate that mir-26b inhibits autophagy through targeting ULK2 which is up-regulated in PCa prostate cancer hsa-miR-361-5p ULK2 0.971859117235239 5.30236555707088e-09 -0.582426572411284 0.00379371000646104 miRanda;miRNATAP -0.119325589320004 0.0417407337553628 NA NA NA hsa-miR-362-3p ULK2 2.0756816987665 3.89026064579331e-12 -0.582426572411284 0.00379371000646104 miRNATAP -0.107486427614139 0.00106480930288894 NA NA NA hsa-miR-576-5p ULK2 2.20467023993664 3.4053475193793e-19 -0.582426572411284 0.00379371000646104 mirMAP -0.157539740944837 3.14539499378473e-05 NA NA NA hsa-miR-582-5p ULK2 0.609226359812689 0.032988717891497 -0.582426572411284 0.00379371000646104 miRNATAP -0.156069010259381 4.20782665050971e-06 NA NA NA hsa-miR-590-3p ULK2 2.59289455139753 1.03200520972022e-21 -0.582426572411284 0.00379371000646104 mirMAP -0.16610742386826 2.02217872445913e-06 NA NA NA hsa-miR-125b-5p ULK3 -1.16462950151259 0.000288900271798384 0.488619672684837 0.00278933779897925 miRNAWalker2_validate -0.134861810614726 2.44640037676076e-08 NA NA NA hsa-miR-125a-5p UNC5C 0.599529391575274 0.0102300147180307 -2.85842438529154 7.1455313233325e-10 miRanda -0.454361278445087 3.35939034132257e-06 NA NA NA hsa-miR-125a-5p USP12 0.599529391575274 0.0102300147180307 -1.44507046271225 1.43898976239535e-07 PITA;miRanda -0.34256936634667 1.89061732653362e-09 NA NA NA hsa-miR-125a-5p UTP20 0.599529391575274 0.0102300147180307 0.314523336895991 0.0347549105667507 miRanda -0.119917490013567 9.86686130996791e-05 NA NA NA hsa-miR-1-3p VEGFA -3.48370702447685 1.98579484008516e-13 0.471653090802802 0.0989904385682923 MirTarget -0.202978528176548 1.57292170658149e-13 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-133a-3p VEGFA -3.38501431117712 1.32336729742128e-13 0.471653090802802 0.0989904385682923 miRNAWalker2_validate -0.190996958246616 2.70660605752725e-11 NA NA NA hsa-miR-134-5p VEGFA 0.141163006984518 0.655334296084178 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase;MirTarget -0.180227374251871 3.58435465670397e-05 NA NA NA hsa-miR-145-5p VEGFA -1.55259331973517 9.97889123247165e-07 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase -0.277645238248207 4.72205041776188e-11 24966896;24781864;22472569 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL;Overexpression of miR-145 in thyroid cancer cell lines resulted in: decreased cell proliferation migration invasion VEGF secretion and E-cadherin expression; In vivo miR-145 overexpression decreased tumor growth and metastasis in a xenograft mouse model and VEGF secretion;Furthermore the results showed that vascular endothelial growth factor VEGF expression was down-regulated in osteosarcoma cells after miR-145 transfection; On the basis of these results we performed the luciferase assay and verified that miR-145 could down-regulate VEGF at the translational level by partially binding to VEGF 3' untranslated region 3'UTR; One of the mechanisms is the down-regulation of VEGF expression by miR-145 by binding to the 3'UTR of VEGF mRNA specifically ;metastasis; bladder cancer;thyroid cancer;sarcoma hsa-miR-150-5p VEGFA -0.105827294491332 0.799351458244375 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase -0.164137084593398 6.0374913950269e-07 NA NA NA hsa-miR-195-5p VEGFA -1.44753678070504 8.70594292149271e-09 0.471653090802802 0.0989904385682923 miRNAWalker2_validate;miRTarBase;MirTarget -0.21863878149299 5.11037236008283e-05 27574422;23468064;26823724 In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC ;;metastasis liver cancer;liver cancer;liver cancer hsa-miR-199a-5p VEGFA 0.592984035153911 0.0674836634175293 0.471653090802802 0.0989904385682923 miRanda;miRNATAP -0.205612739501636 1.1489897892283e-06 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA 0.218704279044827 0.519493319158441 0.471653090802802 0.0989904385682923 miRanda -0.175899050515122 1.43171320791549e-05 NA NA NA hsa-miR-29a-3p VEGFA -0.35074463683376 0.161238718982428 0.471653090802802 0.0989904385682923 MirTarget -0.313847513848792 9.68544057650496e-09 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-342-3p VEGFA 1.49115144672245 1.43879249744621e-07 0.471653090802802 0.0989904385682923 miRanda;miRNATAP -0.166390639835536 0.000539599594707828 23408138 Statistically significant associations were observed between miR-342 and ER HER2 and vascular endothelial growth factor VEGF status in the human breast cancer samples and the levels of miR-342 gradually increased as ERĪ± mRNA expression increased breast cancer hsa-miR-374b-5p VEGFA 0.0654362503857184 0.722673188879465 0.471653090802802 0.0989904385682923 MirTarget -0.254824056474554 0.000792850845311603 NA NA NA hsa-miR-655-3p VEGFA 0.485339318272148 0.137014658258732 0.471653090802802 0.0989904385682923 MirTarget -0.164823030617487 0.000126415331270495 NA NA NA hsa-miR-128-3p VEGFC 1.63756041666078 6.79626586407187e-14 -0.457873556695705 0.178610332401836 miRNAWalker2_validate;MirTarget -0.377058704312277 2.16798927147771e-07 26722309;25001183 miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells;Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways metastasis; bladder cancer;lung squamous cell cancer hsa-miR-27b-3p VEGFC 0.196007704287769 0.295630157035388 -0.457873556695705 0.178610332401836 MirTarget -0.184894953706514 0.038219701457811 23593282 We identified vascular endothelial growth factor C VEGFC as a novel target gene of miR-27b and determined that miR-27b functioned as an inhibitor of tumor progression and angiogenesis through targeting VEGFC in CRC; In summary an anti-tumor role for miR-27b and its novel target VEGFC in vivo could lead to tumor necrosis and provide a rationale for developing miR-27b as a therapeutic agent progression colorectal cancer hsa-miR-125a-5p VNN3 0.599529391575274 0.0102300147180307 -0.671245684544405 0.229092182667699 miRanda -0.534408054701175 3.47946416539779e-06 NA NA NA hsa-miR-125a-5p VPS13D 0.599529391575274 0.0102300147180307 -0.873698098644587 1.82957568574832e-11 miRanda -0.103933104785852 0.00015842586895801 NA NA NA hsa-miR-125a-5p WARS 0.599529391575274 0.0102300147180307 0.561889426937364 0.116098284852563 MirTarget;miRanda;miRNATAP -0.55203993739011 2.12341506259127e-14 NA NA NA hsa-miR-125a-5p WDFY4 0.599529391575274 0.0102300147180307 -1.52835958077685 0.00208595788951407 mirMAP -0.488846165756864 2.02096178483308e-06 NA NA NA hsa-miR-125a-5p WDR5 0.599529391575274 0.0102300147180307 0.577462417326456 4.82326927041334e-05 MirTarget -0.142667169128794 1.24607859935115e-06 NA NA NA hsa-miR-125a-5p WDR62 0.599529391575274 0.0102300147180307 2.70045037620421 7.829972028422e-20 miRanda -0.15276017455227 0.0181559783682087 NA NA NA hsa-miR-125a-5p WDR92 0.599529391575274 0.0102300147180307 0.254616452076971 0.0432239984692754 miRanda -0.113159170980754 1.27640215295032e-05 NA NA NA hsa-miR-125a-5p WIPF3 0.599529391575274 0.0102300147180307 -0.616147746529439 0.187871181271044 miRanda -0.609422966398032 1.73217445635655e-10 NA NA NA hsa-miR-125a-5p YLPM1 0.599529391575274 0.0102300147180307 -0.458036086972552 7.33474264078578e-05 miRanda -0.132399055029428 2.48742000567413e-08 NA NA NA hsa-miR-125a-5p ZBTB37 0.599529391575274 0.0102300147180307 -0.575470462840692 0.0106071831245277 miRanda;miRNATAP -0.186197621286283 6.67827056038377e-05 NA NA NA hsa-miR-125a-5p ZBTB6 0.599529391575274 0.0102300147180307 0.062674737069651 0.673402031501082 miRanda -0.167314856701581 3.67462467049692e-08 NA NA NA hsa-miR-125a-5p ZDHHC14 0.599529391575274 0.0102300147180307 -0.420877670161361 0.0714978913519264 miRanda;mirMAP -0.12647082279091 0.00925308463078782 NA NA NA hsa-miR-125a-5p ZEB2 0.599529391575274 0.0102300147180307 -2.26388876645177 1.13775147583663e-12 miRanda -0.401421484964504 2.06676585511455e-09 NA NA NA hsa-miR-125a-5p ZFHX4 0.599529391575274 0.0102300147180307 -2.72243653694716 1.46650038380412e-06 miRanda -0.704305023523128 1.83079824730707e-09 NA NA NA hsa-miR-125a-5p ZNF281 0.599529391575274 0.0102300147180307 0.0416620203780278 0.888110347621826 miRanda;miRNATAP -0.399294235248697 3.31973470616983e-11 NA NA NA hsa-miR-125a-5p ZNF460 0.599529391575274 0.0102300147180307 -0.641261854004098 0.00206827243700115 miRanda;miRNATAP -0.171521641815871 7.27069527580438e-05 NA NA NA hsa-miR-125a-5p ZNF518B 0.599529391575274 0.0102300147180307 -0.27656515919045 0.381404725780156 miRanda -0.132536298913751 0.0440123295902536 NA NA NA hsa-miR-125a-5p ZNF618 0.599529391575274 0.0102300147180307 0.592147632241502 0.0316311175948786 miRanda;mirMAP -0.172704987191634 0.00259283538321604 NA NA NA hsa-miR-125a-5p ZNF710 0.599529391575274 0.0102300147180307 -0.166758515976001 0.33741345363751 mirMAP -0.129289413148298 0.000322135078948024 NA NA NA