miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p AIFM1 -0.328069937201898 0.000464344093744051 -0.385341500009001 0.000487220407124204 TargetScan;miRNATAP -0.156878186610717 0.00688659078633595 NA NA NA hsa-let-7b-5p AIFM1 -0.959013717270803 5.95127281258643e-11 -0.385341500009001 0.000487220407124204 miRNATAP -0.0889284522404483 0.0139001114962213 NA NA NA hsa-let-7d-5p AIFM1 0.0503292020123807 0.702580311853671 -0.385341500009001 0.000487220407124204 miRNATAP -0.227865460454543 2.10775715366441e-08 NA NA NA hsa-let-7e-5p AIFM1 0.0350298755544731 0.811068614727804 -0.385341500009001 0.000487220407124204 miRNATAP -0.265623018485343 1.69105242803182e-13 NA NA NA hsa-let-7i-5p AIFM1 -0.14267936165213 0.154141689875847 -0.385341500009001 0.000487220407124204 miRNATAP -0.270178971706901 5.63343817647883e-07 NA NA NA hsa-miR-125a-5p AIFM1 -0.91219969372382 1.38256246489548e-07 -0.385341500009001 0.000487220407124204 miRanda -0.143782175885177 2.45198736443818e-06 NA NA NA hsa-miR-155-5p AIFM1 0.0108524225071784 0.95651331033505 -0.385341500009001 0.000487220407124204 miRNAWalker2_validate -0.087503355009724 0.0012705719648358 NA NA NA hsa-miR-20a-3p AIFM1 -0.318177901603857 0.0467885456739855 -0.385341500009001 0.000487220407124204 miRNATAP -0.114832354479707 0.000674172928292269 NA NA NA hsa-miR-425-5p AIFM1 0.585974239943864 2.23063410931402e-05 -0.385341500009001 0.000487220407124204 miRNATAP -0.15215692760595 8.49396965138554e-05 NA NA NA hsa-miR-429 AIFM1 -1.40262535827285 6.93982219171912e-05 -0.385341500009001 0.000487220407124204 miRNATAP -0.0880849275806901 5.97224246841537e-09 NA NA NA hsa-miR-125a-5p AKT2 -0.91219969372382 1.38256246489548e-07 -0.343608685894869 1.25471482871759e-05 mirMAP -0.0538556405150209 0.0142021309582807 NA NA NA hsa-miR-149-5p AKT2 -0.317176971910036 0.187207559733877 -0.343608685894869 1.25471482871759e-05 miRNAWalker2_validate -0.0792951398317154 6.48076637110885e-07 NA NA NA hsa-miR-183-5p AKT2 2.33444328833177 1.52188109365421e-10 -0.343608685894869 1.25471482871759e-05 mirMAP -0.0553038374330303 5.42515253047027e-08 NA NA NA hsa-miR-1976 AKT2 -0.431472440543166 0.00324575010550946 -0.343608685894869 1.25471482871759e-05 miRNATAP -0.0530606134481201 0.0438073695033098 NA NA NA hsa-miR-21-5p AKT2 1.51084295924322 1.54551622173259e-34 -0.343608685894869 1.25471482871759e-05 miRNAWalker2_validate -0.246625533117166 4.43585626011661e-19 NA NA NA hsa-miR-330-5p AKT2 0.442231058604099 0.0053308560843808 -0.343608685894869 1.25471482871759e-05 miRanda -0.10429759179516 1.49133299948889e-05 NA NA NA hsa-miR-338-3p AKT2 0.543135607704581 0.00461167747143826 -0.343608685894869 1.25471482871759e-05 mirMAP -0.0911696762425927 4.49968509568086e-06 NA NA NA hsa-miR-342-3p AKT2 -0.319677314984262 0.0449813878317147 -0.343608685894869 1.25471482871759e-05 mirMAP -0.124944719707983 1.72780303356483e-07 NA NA NA hsa-miR-671-5p AKT2 0.843645373345787 3.92794196273313e-08 -0.343608685894869 1.25471482871759e-05 miRNATAP -0.0629785135376934 0.0110682283592117 NA NA NA hsa-miR-766-3p AKT2 0.199979324759329 0.257230732626744 -0.343608685894869 1.25471482871759e-05 mirMAP -0.0607960504032571 0.00542411924697383 NA NA NA hsa-miR-106b-5p AKT3 0.648901865047099 8.24870862047885e-09 -0.658799312069129 0.000471762262250455 miRNATAP -0.257549207275002 0.00147770551388523 NA NA NA hsa-miR-107 AKT3 0.241662461253461 0.0170788899505389 -0.658799312069129 0.000471762262250455 PITA;miRanda -0.603074134996255 1.95007791380395e-11 NA NA NA hsa-miR-122-5p AKT3 -1.23907441373955 4.42181244888642e-06 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase -0.282597613468804 3.13172096832783e-18 24244539 miR 122 regulates tumorigenesis in hepatocellular carcinoma by targeting AKT3; Here we identify AKT3 as a novel and direct target of miR-122; Restoration of miR-122 expression in HCC cell lines decreases AKT3 levels inhibits cell migration and proliferation and induces apoptosis; These anti-tumor phenotypes can be rescued by reconstitution of AKT3 expression indicating the essential role of AKT3 in miR-122 mediated HCC transformation; Our data strongly suggest that miR-122 is a tumor suppressor that targets AKT3 to regulate tumorigenesis in HCCs and a potential therapeutic candidate for liver cancer tumorigenesis;cell migration liver cancer hsa-miR-146b-5p AKT3 0.419719546795449 0.0457375823220155 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate -0.159678144375669 0.000263366078999813 NA NA NA hsa-miR-15a-5p AKT3 0.349521211668244 0.000770735998804736 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265425410812535 0.00291348888530609 NA NA NA hsa-miR-17-3p AKT3 0.410352776142368 0.00422200500748636 -0.658799312069129 0.000471762262250455 miRNATAP -0.350392140268267 3.46133659001702e-08 NA NA NA hsa-miR-17-5p AKT3 0.698861147045461 2.43854106455398e-05 -0.658799312069129 0.000471762262250455 TargetScan;miRNATAP -0.290786763807918 1.04942988053081e-07 NA NA NA hsa-miR-20a-5p AKT3 0.854326758727003 5.04256669663285e-07 -0.658799312069129 0.000471762262250455 miRNATAP -0.294574079686222 2.60181650003526e-08 NA NA NA hsa-miR-32-3p AKT3 0.219109440121582 0.207217051619543 -0.658799312069129 0.000471762262250455 mirMAP -0.225932925933496 3.62088303609835e-05 NA NA NA hsa-miR-33a-3p AKT3 -0.683025859637737 1.01106097756419e-05 -0.658799312069129 0.000471762262250455 mirMAP -0.229716914608906 0.000100074832030455 NA NA NA hsa-miR-362-3p AKT3 0.814007335895913 2.00108618836568e-09 -0.658799312069129 0.000471762262250455 miRanda -0.223301194831745 0.00083465748836002 NA NA NA hsa-miR-362-5p AKT3 0.717921690799312 1.68392734504524e-05 -0.658799312069129 0.000471762262250455 PITA;TargetScan;miRNATAP -0.147261080417749 0.00734435768679755 NA NA NA hsa-miR-374a-5p AKT3 0.016390363747302 0.869784217438621 -0.658799312069129 0.000471762262250455 mirMAP -0.277843537840681 0.00293899073092604 NA NA NA hsa-miR-421 AKT3 0.941856334694081 6.12167297054077e-08 -0.658799312069129 0.000471762262250455 miRanda;mirMAP -0.133809007743249 0.0109099775591746 NA NA NA hsa-miR-501-3p AKT3 0.999540908940094 2.77358485581974e-11 -0.658799312069129 0.000471762262250455 miRNATAP -0.119128898090902 0.0482272940757398 NA NA NA hsa-miR-502-3p AKT3 0.659598854007546 3.01316453996423e-08 -0.658799312069129 0.000471762262250455 miRNATAP -0.256952206617794 0.000795069967308112 NA NA NA hsa-miR-616-5p AKT3 0.150569904638223 0.402836556304524 -0.658799312069129 0.000471762262250455 mirMAP -0.200000357827185 9.73725948226915e-05 NA NA NA hsa-miR-93-5p AKT3 1.39518349670953 2.84167728726712e-25 -0.658799312069129 0.000471762262250455 miRNATAP -0.283992832133781 1.04884093066001e-05 NA NA NA hsa-miR-139-5p APAF1 -2.11299531796557 8.16407076415038e-28 0.221562966629638 0.0142978159207097 mirMAP -0.0954896444398438 6.09667520527515e-06 NA NA NA hsa-miR-3607-3p APAF1 -2.15518588554493 1.03390728226728e-23 0.221562966629638 0.0142978159207097 mirMAP;miRNATAP -0.0705633153860172 0.00025252277469315 NA NA NA hsa-miR-30d-3p ATM -0.120562286038759 0.329549534782125 -0.236058797850924 0.0173776926910908 mirMAP -0.138156674894502 0.00042794166032829 24345332 miR-30d has been observed to be significantly down-regulated in human anaplastic thyroid carcinoma ATC and is believed to be an important event in thyroid cell transformation; In this study we found that miR-30d has a critical role in modulating sensitivity of ATC cells to cisplatin a commonly used chemotherapeutic drug for treatment of this neoplasm; Using a mimic of miR-30d we demonstrated that miR-30d could negatively regulate the expression of beclin 1 a key autophagy gene leading to suppression of the cisplatin-activated autophagic response that protects ATC cells from apoptosis; We further showed that inhibition of the beclin 1-mediated autophagy by the miR-30d mimic sensitized ATC cells to cisplatin both in vitro cell culture and in vivo animal xenograft model; These results suggest that dysregulation of miR-30d in ATC cells is responsible for the insensitivity to cisplatin by promoting autophagic survival; Thus miR-30d may be exploited as a potential target for therapeutic intervention in the treatment of ATC drug resistance;poor survival thyroid cancer hsa-miR-30d-5p ATM 0.718283816348023 2.47422074061352e-08 -0.236058797850924 0.0173776926910908 mirMAP -0.0769726263034235 0.0381377002391779 24345332 miR-30d has been observed to be significantly down-regulated in human anaplastic thyroid carcinoma ATC and is believed to be an important event in thyroid cell transformation; In this study we found that miR-30d has a critical role in modulating sensitivity of ATC cells to cisplatin a commonly used chemotherapeutic drug for treatment of this neoplasm; Using a mimic of miR-30d we demonstrated that miR-30d could negatively regulate the expression of beclin 1 a key autophagy gene leading to suppression of the cisplatin-activated autophagic response that protects ATC cells from apoptosis; We further showed that inhibition of the beclin 1-mediated autophagy by the miR-30d mimic sensitized ATC cells to cisplatin both in vitro cell culture and in vivo animal xenograft model; These results suggest that dysregulation of miR-30d in ATC cells is responsible for the insensitivity to cisplatin by promoting autophagic survival; Thus miR-30d may be exploited as a potential target for therapeutic intervention in the treatment of ATC drug resistance;poor survival thyroid cancer hsa-miR-324-5p ATM 0.372933276649782 0.00592280066108904 -0.236058797850924 0.0173776926910908 miRanda -0.093288754796766 0.00899731669015663 NA NA NA hsa-miR-339-5p ATM 0.280589919878422 0.0355660282647215 -0.236058797850924 0.0173776926910908 miRanda -0.1044932927788 0.00399236512159519 NA NA NA hsa-miR-455-5p ATM -0.270546034117157 0.0581320703577731 -0.236058797850924 0.0173776926910908 miRanda -0.118715671502599 0.000450782297458542 NA NA NA hsa-miR-127-3p BAD -1.0751374948053 2.19322892330221e-05 0.0692427481111428 0.509414212060742 miRanda;miRNATAP -0.0656170497917662 0.000958637772170528 NA NA NA hsa-miR-122-5p BAX -1.23907441373955 4.42181244888642e-06 0.800291917132606 7.28210427550269e-13 miRNAWalker2_validate -0.093227929914008 4.24922072841264e-06 NA NA NA hsa-miR-30a-5p BAX -0.626257932887855 0.000108198196973765 0.800291917132606 7.28210427550269e-13 miRNAWalker2_validate -0.117791332970104 0.00058384847557231 NA NA NA hsa-miR-365a-3p BAX 0.164591326307714 0.15325084963213 0.800291917132606 7.28210427550269e-13 miRNAWalker2_validate -0.229448386158489 2.12152243741233e-06 24216611 MiR 365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro apoptotic regulator BAX drug resistance pancreatic cancer hsa-miR-103a-3p BCL2 0.765568928457606 3.05497476509383e-12 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate -0.276206643708183 3.69212207145036e-05 NA NA NA hsa-miR-130b-5p BCL2 0.170599813152408 0.337611586432771 -0.34630447089245 0.0249701729768122 mirMAP -0.1684334796147 6.63359359340854e-05 27364335 The level of microRNA-130b in relationship with the expression of PPARγ VEGF-A BCL-2 and apoptosis were analyzed in 91 lung cancer patient samples using immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick end labeling TUNEL assay on tissue microarrays; In vitro and in vivo miR-130b enrichment associated with down-regulation of PPARγ up-regulation of VEGF-A and BCL-2 and decreased apoptosis lung cancer hsa-miR-148a-3p BCL2 -0.748702855596996 3.93313343865641e-07 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate;miRTarBase -0.309765293468013 4.08540378699783e-10 21455217;23975374 MiR 148a promotes apoptosis by targeting Bcl 2 in colorectal cancer;MiR 148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl 2; Using western blot and luciferase activity assay CCKBR and Bcl-2 were identified as targets of miR-148a; Moreover we also found that the expression of Bcl-2 lacking in 3'UTR could abrogate the pro-apoptosis function of miR-148a ; colorectal cancer;pancreatic cancer hsa-miR-15a-5p BCL2 0.349521211668244 0.000770735998804736 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate;miRTarBase -0.167328042777219 0.021723913927065 25594541;26915294;18931683;25623762;22335947 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 ;poor survival;;drug resistance; breast cancer;lung cancer;prostate cancer;colon cancer;breast cancer hsa-miR-15b-3p BCL2 0.238105490431193 0.0997721500357416 -0.34630447089245 0.0249701729768122 mirMAP -0.104302771580962 0.0463811876311607 26884837;25594541;26915294;18449891 MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 ;;poor survival;drug resistance liver cancer;breast cancer;lung cancer;gastric cancer hsa-miR-17-5p BCL2 0.698861147045461 2.43854106455398e-05 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate;miRTarBase -0.3141879354563 9.49080059686353e-13 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-186-5p BCL2 -0.060103391373687 0.535288717081205 -0.34630447089245 0.0249701729768122 mirMAP -0.253682116313365 0.00124603296329075 NA NA NA hsa-miR-192-5p BCL2 -0.50188499512787 0.00344713341196035 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate -0.343159016245154 5.19113742652329e-16 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-204-5p BCL2 -0.537962150012103 0.0330895493358849 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate;miRTarBase -0.0837561082904349 0.00496032957848847 25652855;23152059;26191195;27519795;25209181 The expressions of Bcl-2 and Sirt1 in the lower miR-204 level group were both higher than those in the higher miR-204 level group; Correlation analysis showed that miR-204 expression was negatively correlated with Bcl-2 and Sirt1 protein expression levels; Over-expressed miR-204 in SMMC-7721 cells suppressed cell proliferation and promoted cell apoptosis and down-regulated mRNA and protein expressions of both Bcl-2 and Sirt1; miR-204 could inhibit HCC cell proliferation and induce apoptosis by down-regulating the expressions of Bcl-2 and Sirt1;miR 204 targets Bcl 2 expression and enhances responsiveness of gastric cancer; Downregulation of miR-204 has prognostic value and correlates with increased staining of Bcl-2 protein in tumoral specimens; miR-204 targeted Bcl-2 messenger RNA and increased responsiveness of GC cells to 5-fluorouracil and oxaliplatin treatment; Ectopic expression of Bcl-2 protein counteracted miR-204 pro-apoptotic activity in response to 5-fluorouracil; Altogether these findings suggest that modulation of aberrant expression of miR-204 which in turn releases oncogenic Bcl-2 protein activity might hold promise for preventive and therapeutic strategies of GC;Moreover the level of miR-204 is negatively correlated with p-STAT3 and anti-apoptotic genes BCl-2 and surviving in breast cancer;Human miR-204-5p potentially targeting BCL2 has been reported to be downregulated in various cancers; We hypothesized that miR-204-5p overexpression induces cancer cell apoptosis by repressing BCL2 expression; Luciferase reporter assays were performed to verify the function of mature miR-204-5p and its direct binding to BCL2 transcripts; Human miR-204-5p targets BCL2 in PCa cells; Restoration of miR-204-5p in PCa could therefore be considered as a novel strategy by targeting antiapoptotic BCL2;This may be explained by the fact that miR-204-5p increases in colorectal cancer cases in order to inhibit increased activity of LC3B-II in autophagy and Bcl2 against apoptosis posttranscriptionally and to take role as tumor suppressor ;drug resistance;;; liver cancer;gastric cancer;breast cancer;prostate cancer;colorectal cancer hsa-miR-20a-3p BCL2 -0.318177901603857 0.0467885456739855 -0.34630447089245 0.0249701729768122 mirMAP -0.241984307767668 2.15054512819723e-07 NA NA NA hsa-miR-20a-5p BCL2 0.854326758727003 5.04256669663285e-07 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate;miRTarBase -0.309280985956287 4.00465486003896e-13 NA NA NA hsa-miR-32-3p BCL2 0.219109440121582 0.207217051619543 -0.34630447089245 0.0249701729768122 mirMAP -0.197220723036098 9.60236464107476e-06 NA NA NA hsa-miR-33a-5p BCL2 -0.767474460958522 1.09948756118522e-05 -0.34630447089245 0.0249701729768122 mirMAP -0.10968254523923 0.010406345573742 NA NA NA hsa-miR-34a-5p BCL2 1.03694231790865 5.74864019540594e-14 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate;miRTarBase -0.113194223983593 0.0332892113643548 23862748;24565525;23155233;24444609;20687223;22623155;24988056;18803879;19714243;25053345;20433755;21399894;22964582 MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression;In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2 ;drug resistance;;poor survival;drug resistance;;;poor survival;differentiation;poor survival;drug resistance;;; liver cancer;breast cancer;glioblastoma;lung squamous cell cancer;prostate cancer;breast cancer;gastric cancer;gastric cancer;pancreatic cancer;prostate cancer;colon cancer;breast cancer;lung cancer hsa-miR-365a-3p BCL2 0.164591326307714 0.15325084963213 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate;miRTarBase -0.325345655719122 6.00535770562877e-07 NA NA NA hsa-miR-374a-5p BCL2 0.016390363747302 0.869784217438621 -0.34630447089245 0.0249701729768122 mirMAP -0.176132494827185 0.0211125155112226 NA NA NA hsa-miR-455-5p BCL2 -0.270546034117157 0.0581320703577731 -0.34630447089245 0.0249701729768122 mirMAP -0.187920872762485 0.00036775461526632 NA NA NA hsa-miR-590-5p BCL2 -0.103355559980404 0.310027295317092 -0.34630447089245 0.0249701729768122 miRanda -0.288806204300719 0.000105733783342118 NA NA NA hsa-miR-616-5p BCL2 0.150569904638223 0.402836556304524 -0.34630447089245 0.0249701729768122 mirMAP -0.279996287836879 9.62044185440687e-12 NA NA NA hsa-miR-618 BCL2 0.13539895350352 0.517145913114103 -0.34630447089245 0.0249701729768122 mirMAP -0.20993134438608 1.19441927849968e-08 NA NA NA hsa-miR-142-3p BCL2L1 -1.4243101967815 1.92609481097765e-14 0.0225608953357561 0.827445946886033 miRNATAP -0.0860114610633176 0.000977190440129909 NA NA NA hsa-miR-149-5p BCL2L1 -0.317176971910036 0.187207559733877 0.0225608953357561 0.827445946886033 mirMAP -0.0534922132538217 0.0108846806332933 NA NA NA hsa-miR-326 BCL2L1 -1.881935132554 1.68087316863775e-21 0.0225608953357561 0.827445946886033 PITA;miRanda;mirMAP;miRNATAP -0.0853855531435943 0.00044613240550679 NA NA NA hsa-miR-330-5p BCL2L1 0.442231058604099 0.0053308560843808 0.0225608953357561 0.827445946886033 PITA;miRanda;miRNATAP -0.154730615864034 7.70545597695822e-07 NA NA NA hsa-miR-342-3p BCL2L1 -0.319677314984262 0.0449813878317147 0.0225608953357561 0.827445946886033 PITA;miRanda;miRNATAP -0.123843624743073 7.98408137042515e-05 NA NA NA hsa-miR-342-5p BCL2L1 -0.780720763816797 5.21703298730986e-07 0.0225608953357561 0.827445946886033 miRNATAP -0.106591893041378 0.000835493298714261 NA NA NA hsa-miR-484 BCL2L1 0.0857240033709656 0.453982056282229 0.0225608953357561 0.827445946886033 miRNAWalker2_validate -0.214137045460272 1.02827848229123e-06 NA NA NA hsa-miR-491-5p BCL2L1 -0.369122930844418 0.0154047757048929 0.0225608953357561 0.827445946886033 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda -0.0804323160293173 0.0158624427333723 25299770;20039318;23519249 We found that miR-491-5p efficiently induces apoptosis in IGROV1-R10 cells by directly inhibiting BCL-XL expression and by inducing BIM accumulation in its dephosphorylated form;Functional screening identifies a microRNA miR 491 that induces apoptosis by targeting Bcl XL in colorectal cancer cells; We demonstrated that Bcl-XL was a direct target of miR-491 and its silencing contributed to miR-491-induced apoptosis; Our study provides a new regulation of Bcl-XL by miR-491 in colorectal cancer cells and suggests a therapeutic potential of miRNAs for treating colorectal cancer by targeting Bcl-XL;Targeted site prediction indicated that both Bcl-XL and TP53 contain miR-491-5p recognizing sites in their 3' UTRs; Overexpression of miR-491-5p in the pancreatic cancer cell line SW1990 effectively inhibited both endogenous Bcl-XL and TP53 gene expressions ;; ovarian cancer;colorectal cancer;pancreatic cancer hsa-miR-940 BCL2L1 0.453020092551484 0.0177054921651997 0.0225608953357561 0.827445946886033 mirMAP -0.0784082092304714 0.00372885113709862 NA NA NA hsa-miR-140-5p BID -0.220106443070144 0.0140713197101242 0.212028711841568 0.0751625972679542 miRanda -0.214836635124566 0.00100941241708294 NA NA NA hsa-miR-29b-3p BIRC2 -0.348885528720517 0.0121441341291285 -0.31649476081183 4.2755643146566e-06 MirTarget -0.0634626083850458 0.00891830454939798 NA NA NA hsa-miR-330-3p BIRC2 -0.332364259424489 0.0316051913061459 -0.31649476081183 4.2755643146566e-06 miRNATAP -0.0575196985126092 0.00997962753546555 NA NA NA hsa-miR-500a-5p BIRC2 0.797906382969156 9.15958171084226e-08 -0.31649476081183 4.2755643146566e-06 MirTarget -0.0711686621243344 0.00137406263136677 NA NA NA hsa-miR-24-1-5p BIRC3 -1.3235267368749 6.56628864624956e-23 0.345666703943572 0.159762716827606 MirTarget -0.298989455936807 0.000402007450494458 NA NA NA hsa-miR-26b-5p BIRC3 -1.10804856399744 4.14176110314282e-22 0.345666703943572 0.159762716827606 mirMAP -0.351728818879341 0.000406492135983019 NA NA NA hsa-miR-374a-5p BIRC3 0.016390363747302 0.869784217438621 0.345666703943572 0.159762716827606 mirMAP -0.556409792541405 3.74975496877103e-06 NA NA NA hsa-miR-374b-5p BIRC3 -0.307538028546424 0.0030079617545972 0.345666703943572 0.159762716827606 mirMAP -0.302534509430598 0.00930293938825019 NA NA NA hsa-miR-616-3p BIRC3 -0.699516741506971 1.82225985970292e-05 0.345666703943572 0.159762716827606 MirTarget -0.146080474452853 0.0459986152495693 NA NA NA hsa-miR-651-5p BIRC3 -0.244364876887077 0.0817536678437599 0.345666703943572 0.159762716827606 MirTarget -0.276810228320716 0.00126215570675979 NA NA NA hsa-miR-664a-3p BIRC3 0.485807855553031 0.000732553249798598 0.345666703943572 0.159762716827606 mirMAP -0.269205785296152 0.00117865263516174 NA NA NA hsa-miR-140-5p CAPN1 -0.220106443070144 0.0140713197101242 0.203975388211385 0.0133808943356494 miRanda;miRNATAP -0.150314202932084 0.000874565895684601 NA NA NA hsa-miR-101-3p CAPN2 -1.48176407980989 3.98950707385704e-31 0.655194969240925 1.21295078937538e-07 miRNAWalker2_validate;MirTarget -0.211136325324757 1.73986621368963e-06 NA NA NA hsa-miR-107 CAPN2 0.241662461253461 0.0170788899505389 0.655194969240925 1.21295078937538e-07 miRanda -0.196117552086705 0.00125089180439756 NA NA NA hsa-miR-1468-5p CAPN2 -1.21475558175193 2.52286949987832e-09 0.655194969240925 1.21295078937538e-07 MirTarget -0.09864841747185 0.00079471195221086 NA NA NA hsa-miR-16-2-3p CAPN2 -0.0336420826463706 0.805158952566973 0.655194969240925 1.21295078937538e-07 mirMAP -0.154414276957788 0.000599368567853864 NA NA NA hsa-miR-20a-3p CAPN2 -0.318177901603857 0.0467885456739855 0.655194969240925 1.21295078937538e-07 MirTarget -0.130110134544505 0.000666312924360847 NA NA NA hsa-miR-299-5p CAPN2 -1.29140172063665 7.07032129116092e-07 0.655194969240925 1.21295078937538e-07 MirTarget -0.0593185762559661 0.0123707338015637 NA NA NA hsa-miR-33a-3p CAPN2 -0.683025859637737 1.01106097756419e-05 0.655194969240925 1.21295078937538e-07 mirMAP -0.129476598310856 0.000960162955941016 NA NA NA hsa-miR-421 CAPN2 0.941856334694081 6.12167297054077e-08 0.655194969240925 1.21295078937538e-07 miRanda -0.0722990552529736 0.0381101845352452 NA NA NA hsa-miR-548j-5p CAPN2 0.251239647701947 0.171361975450222 0.655194969240925 1.21295078937538e-07 MirTarget -0.0705344317303047 0.0409723939067951 NA NA NA hsa-miR-590-3p CAPN2 -0.473167498047808 1.76652934637227e-05 0.655194969240925 1.21295078937538e-07 miRanda -0.223109477706343 5.17584726080661e-05 NA NA NA hsa-miR-590-5p CAPN2 -0.103355559980404 0.310027295317092 0.655194969240925 1.21295078937538e-07 miRanda -0.244661447544334 5.15285994880349e-05 NA NA NA hsa-miR-30b-3p CASP10 -0.439724365151373 0.000947180503583586 -0.15929258204733 0.0614384938167968 MirTarget -0.071200519679416 0.0221254445974979 NA NA NA hsa-let-7g-5p CASP3 -0.461294133285527 2.17210114729901e-05 0.309149151776334 0.000465712323457523 MirTarget;miRNATAP -0.107118384912517 0.00693887247949783 NA NA NA hsa-miR-101-3p CASP3 -1.48176407980989 3.98950707385704e-31 0.309149151776334 0.000465712323457523 MirTarget -0.0863483395600448 0.00599414490442628 NA NA NA hsa-miR-139-5p CASP3 -2.11299531796557 8.16407076415038e-28 0.309149151776334 0.000465712323457523 miRanda -0.0697254160610905 0.000804818450224486 NA NA NA hsa-miR-140-5p CASP3 -0.220106443070144 0.0140713197101242 0.309149151776334 0.000465712323457523 miRanda -0.104439137696992 0.03228174058789 NA NA NA hsa-miR-30a-5p CASP3 -0.626257932887855 0.000108198196973765 0.309149151776334 0.000465712323457523 miRNATAP -0.0747929418830703 0.00478761092593448 NA NA NA hsa-miR-374b-5p CASP3 -0.307538028546424 0.0030079617545972 0.309149151776334 0.000465712323457523 mirMAP -0.143675176440622 0.00057864418465262 NA NA NA hsa-miR-106b-5p CASP7 0.648901865047099 8.24870862047885e-09 -0.716746917395668 1.08880356414289e-12 miRNAWalker2_validate -0.0872170118779774 0.049177013984758 22986525 MicroRNA 106b 25 cluster expression is associated with early disease recurrence and targets caspase 7 and focal adhesion in human prostate cancer; Moreover increased tumor miR-106b expression was associated with disease recurrence and the combination of high miR-106b and low CASP7 caspase-7 expressions in primary tumors was an independent predictor of early disease recurrence adjusted hazard ratio=4.1; 95% confidence interval: 1.6-12.3; The approach revealed that CASP7 is a direct target of miR-106b which was confirmed by western blot analysis and a 3'-untranslated region reporter assay; Moreover selected phenotypes induced by miR-106b knockdown in DU145 human prostate cancer cells did not develop when both miR-106b and CASP7 expression were inhibited recurrence prostate cancer hsa-miR-664a-3p CASP7 0.485807855553031 0.000732553249798598 -0.716746917395668 1.08880356414289e-12 MirTarget -0.0970880717477723 0.00544728936723668 NA NA NA hsa-miR-107 CASP8 0.241662461253461 0.0170788899505389 0.329003138913902 0.000294949473828384 miRanda -0.11196400419093 0.011365992820551 NA NA NA hsa-miR-143-3p CASP8 -0.584123869220553 0.000907217687997436 0.329003138913902 0.000294949473828384 MirTarget -0.0538702098691256 0.0323719722594678 NA NA NA hsa-miR-26b-5p CASP8 -1.10804856399744 4.14176110314282e-22 0.329003138913902 0.000294949473828384 miRNAWalker2_validate -0.0860251230802469 0.0201789880156657 NA NA NA hsa-miR-455-5p CASP8 -0.270546034117157 0.0581320703577731 0.329003138913902 0.000294949473828384 miRanda -0.154954229285754 5.1724046517642e-07 NA NA NA hsa-miR-542-3p CASP8 -1.31351015149842 3.64642423288576e-22 0.329003138913902 0.000294949473828384 miRanda -0.128105307061659 3.53556200230067e-05 NA NA NA hsa-miR-17-5p CASP9 0.698861147045461 2.43854106455398e-05 -0.171869580936377 0.121148185997899 TargetScan -0.0844783762928151 0.0089907050502178 NA NA NA hsa-miR-199a-3p CASP9 -2.3279328685682 1.04468066198593e-17 -0.171869580936377 0.121148185997899 mirMAP -0.0523832271850453 0.005864305609438 23319430 The techniques used were the MTT assay flow cytometry real-time PCR to assess miR-199a expression as also caspase-8 and caspase-9 activity in HepG2 cells treated with Propofol liver cancer hsa-miR-199b-3p CASP9 -2.33226605401203 9.51887435273314e-18 -0.171869580936377 0.121148185997899 mirMAP -0.0523637965909619 0.00584697312879808 NA NA NA hsa-miR-222-5p CASP9 0.125716360553359 0.487423909991138 -0.171869580936377 0.121148185997899 mirMAP -0.093759118740416 0.00170689612904055 NA NA NA hsa-miR-103a-2-5p CFLAR 1.17085533927423 5.31418969120877e-09 -0.332671102072829 2.00694636367654e-06 mirMAP -0.0606920422094989 0.000570064968253408 NA NA NA hsa-miR-107 CFLAR 0.241662461253461 0.0170788899505389 -0.332671102072829 2.00694636367654e-06 miRanda -0.152301413002496 6.91205696307911e-06 NA NA NA hsa-miR-130b-3p CFLAR 0.687190305027546 0.000109068658562255 -0.332671102072829 2.00694636367654e-06 mirMAP -0.054623001330711 0.00440593598920094 NA NA NA hsa-miR-301a-3p CFLAR 0.842910511640361 1.43446467417891e-06 -0.332671102072829 2.00694636367654e-06 mirMAP -0.0595152152438946 0.00212561487114709 NA NA NA hsa-miR-339-5p CFLAR 0.280589919878422 0.0355660282647215 -0.332671102072829 2.00694636367654e-06 miRanda -0.083948940251273 0.00110251310165804 NA NA NA hsa-miR-455-5p CFLAR -0.270546034117157 0.0581320703577731 -0.332671102072829 2.00694636367654e-06 miRanda -0.110213584277723 3.95957481119902e-06 NA NA NA hsa-miR-660-5p CFLAR 0.989755850734071 5.69930767464937e-14 -0.332671102072829 2.00694636367654e-06 mirMAP -0.133551077375969 9.40621335652891e-08 NA NA NA hsa-miR-582-5p CHP2 -0.680189083316822 0.00103755166534107 0.85406323996479 0.0342924238660008 miRNATAP -0.215180348806887 0.0235896474657227 NA NA NA hsa-miR-15a-5p CHUK 0.349521211668244 0.000770735998804736 -0.19932080126218 0.00863163957240649 miRNAWalker2_validate;miRTarBase;MirTarget -0.122536038974783 0.000565424625908096 NA NA NA hsa-miR-15b-5p CHUK 0.230566941413564 0.0824765001857479 -0.19932080126218 0.00863163957240649 MirTarget -0.118017359725558 2.06238744655946e-05 NA NA NA hsa-miR-16-5p CHUK -0.398577235179603 0.000101598495180191 -0.19932080126218 0.00863163957240649 miRNAWalker2_validate;miRTarBase;MirTarget -0.150607357209835 2.62400382273556e-05 NA NA NA hsa-miR-23a-3p CHUK -0.178875974460574 0.135978273540604 -0.19932080126218 0.00863163957240649 MirTarget -0.100438227795724 0.00114468004476388 NA NA NA hsa-miR-29b-2-5p CHUK -0.223258653034772 0.084306146519938 -0.19932080126218 0.00863163957240649 MirTarget -0.0655315632830884 0.0223537221921766 NA NA NA hsa-miR-339-5p CHUK 0.280589919878422 0.0355660282647215 -0.19932080126218 0.00863163957240649 miRanda -0.12221351609504 8.92727609693918e-06 NA NA NA hsa-miR-342-3p CHUK -0.319677314984262 0.0449813878317147 -0.19932080126218 0.00863163957240649 miRanda -0.0633559970220207 0.00621990148635631 NA NA NA hsa-miR-497-5p CHUK -1.41371173021948 7.09278946477743e-17 -0.19932080126218 0.00863163957240649 MirTarget -0.0514293181632368 0.0142088346831951 NA NA NA hsa-miR-590-5p CHUK -0.103355559980404 0.310027295317092 -0.19932080126218 0.00863163957240649 miRanda -0.11766978557823 0.00128889069327197 NA NA NA hsa-miR-19a-3p CSF2RB 1.01712596153672 2.57753201450625e-07 -0.510057706101157 0.00683192745956236 MirTarget -0.120533382582832 0.00885126081922571 NA NA NA hsa-miR-19b-3p CSF2RB 0.601279551368824 0.00016685097085251 -0.510057706101157 0.00683192745956236 MirTarget -0.154504842048333 0.0071335754861484 NA NA NA hsa-miR-204-5p CSF2RB -0.537962150012103 0.0330895493358849 -0.510057706101157 0.00683192745956236 MirTarget -0.111334390280645 0.00224060172110844 NA NA NA hsa-miR-30b-3p CSF2RB -0.439724365151373 0.000947180503583586 -0.510057706101157 0.00683192745956236 MirTarget -0.201103593319895 0.00366034123496103 NA NA NA hsa-miR-455-5p CSF2RB -0.270546034117157 0.0581320703577731 -0.510057706101157 0.00683192745956236 miRanda -0.37382538214599 4.3712193850043e-09 NA NA NA hsa-miR-532-5p CSF2RB 1.02729546510601 9.93318913966636e-16 -0.510057706101157 0.00683192745956236 MirTarget -0.3331966059366 1.42783661157539e-06 NA NA NA hsa-miR-139-5p CYCS -2.11299531796557 8.16407076415038e-28 0.261279109661729 0.0151863050548952 miRanda -0.0577836667328414 0.0228154109750706 NA NA NA hsa-miR-148a-3p CYCS -0.748702855596996 3.93313343865641e-07 0.261279109661729 0.0151863050548952 miRNAWalker2_validate -0.0805919547086087 0.0219953924460167 NA NA NA hsa-miR-361-5p CYCS 0.233202959858696 0.00961572812255327 0.261279109661729 0.0151863050548952 miRNAWalker2_validate -0.172862186931422 0.00330618553619798 NA NA NA hsa-let-7b-5p DFFA -0.959013717270803 5.95127281258643e-11 0.0678724457086854 0.419098982330631 miRNAWalker2_validate -0.107067404976435 7.69501690805216e-05 NA NA NA hsa-miR-145-5p DFFA -1.4795885711477 6.47308361543414e-16 0.0678724457086854 0.419098982330631 miRNAWalker2_validate;miRTarBase -0.0594216283629209 0.00558135808690749 NA NA NA hsa-miR-200b-3p DFFA -1.29335788099229 0.000268623234305059 0.0678724457086854 0.419098982330631 TargetScan;mirMAP -0.050334192842875 8.24260207223208e-06 NA NA NA hsa-miR-26a-2-3p DFFA -0.552429521617 7.7322049253051e-05 0.0678724457086854 0.419098982330631 mirMAP -0.0614914925836391 0.0346142366437577 NA NA NA hsa-miR-26a-5p DFFA -0.963792031426845 1.83360999387345e-22 0.0678724457086854 0.419098982330631 mirMAP -0.160393358100013 4.25358425511916e-05 NA NA NA hsa-miR-335-3p DFFA -0.275199247483111 0.106629165248783 0.0678724457086854 0.419098982330631 mirMAP -0.073593946894676 0.0020537000825613 NA NA NA hsa-miR-335-5p DFFA -1.61347836513558 1.62757083289711e-19 0.0678724457086854 0.419098982330631 mirMAP -0.0727719269950905 0.000814898049082968 NA NA NA hsa-miR-338-5p DFFA -0.221898432884726 0.252390988727086 0.0678724457086854 0.419098982330631 mirMAP -0.0872729549769883 3.28494505089708e-05 NA NA NA hsa-miR-365a-3p DFFB 0.164591326307714 0.15325084963213 0.295356110131766 0.00330961478217344 MirTarget -0.121567381773669 0.00456403483310331 NA NA NA hsa-miR-130b-3p ENDOD1 0.687190305027546 0.000109068658562255 -0.998600185815336 9.70620010845927e-08 MirTarget -0.313603454995876 7.35985290343435e-10 NA NA NA hsa-miR-16-1-3p ENDOD1 0.392360028038559 0.00112481918108198 -0.998600185815336 9.70620010845927e-08 mirMAP -0.453613251765932 2.12551750317036e-09 NA NA NA hsa-miR-192-5p ENDOD1 -0.50188499512787 0.00344713341196035 -0.998600185815336 9.70620010845927e-08 miRNAWalker2_validate -0.463066599557689 2.93930391048484e-19 NA NA NA hsa-miR-193a-3p ENDOD1 -0.117675551589896 0.309391958208578 -0.998600185815336 9.70620010845927e-08 miRanda -0.196573309686065 0.0149445337357031 NA NA NA hsa-miR-193b-3p ENDOD1 -0.166697207281748 0.272022543069482 -0.998600185815336 9.70620010845927e-08 miRNAWalker2_validate -0.220787086438548 0.000300490167878324 NA NA NA hsa-miR-19a-3p ENDOD1 1.01712596153672 2.57753201450625e-07 -0.998600185815336 9.70620010845927e-08 mirMAP -0.284646820540721 3.68998548154196e-10 NA NA NA hsa-miR-19b-3p ENDOD1 0.601279551368824 0.00016685097085251 -0.998600185815336 9.70620010845927e-08 mirMAP -0.342674812633697 1.56455489467667e-09 NA NA NA hsa-miR-20a-3p ENDOD1 -0.318177901603857 0.0467885456739855 -0.998600185815336 9.70620010845927e-08 MirTarget -0.275800394156558 1.6332110332701e-06 NA NA NA hsa-miR-224-3p ENDOD1 1.40770116795301 1.31426607144612e-08 -0.998600185815336 9.70620010845927e-08 mirMAP -0.101105612989004 0.00660341538433555 NA NA NA hsa-miR-301a-3p ENDOD1 0.842910511640361 1.43446467417891e-06 -0.998600185815336 9.70620010845927e-08 MirTarget -0.133493833239928 0.0109120853634808 NA NA NA hsa-miR-361-5p ENDOD1 0.233202959858696 0.00961572812255327 -0.998600185815336 9.70620010845927e-08 MirTarget;miRanda -0.624337627001858 1.021101804084e-09 NA NA NA hsa-miR-3613-5p ENDOD1 0.108670896316992 0.426512924240953 -0.998600185815336 9.70620010845927e-08 MirTarget -0.205615506623261 0.00253521008468026 NA NA NA hsa-miR-362-3p ENDOD1 0.814007335895913 2.00108618836568e-09 -0.998600185815336 9.70620010845927e-08 miRanda -0.338617228290447 3.51718335843851e-07 NA NA NA hsa-miR-589-3p ENDOD1 1.16846704028095 5.88525574424201e-11 -0.998600185815336 9.70620010845927e-08 mirMAP -0.209866246211484 4.75340448905647e-05 NA NA NA hsa-miR-589-5p ENDOD1 1.18593770505086 1.01781241960531e-22 -0.998600185815336 9.70620010845927e-08 MirTarget -0.56350516802131 1.42496533440957e-15 NA NA NA hsa-miR-199a-5p EXOG -1.98848462405923 2.0421622713753e-11 0.809117667842654 9.16571142499629e-17 miRanda -0.0577717890654243 0.000330191201578213 NA NA NA hsa-miR-326 EXOG -1.881935132554 1.68087316863775e-21 0.809117667842654 9.16571142499629e-17 miRanda -0.0804288309078194 0.000734846961673065 NA NA NA hsa-miR-542-3p EXOG -1.31351015149842 3.64642423288576e-22 0.809117667842654 9.16571142499629e-17 miRanda -0.114238895736061 0.000904309475997506 NA NA NA hsa-miR-28-5p FADD -0.430964830599964 2.67367257252925e-06 0.263740805525264 0.00129344387356067 miRanda -0.0861265978429089 0.0485957506463809 NA NA NA hsa-miR-320a FADD 0.325285936317332 0.0221415065838824 0.263740805525264 0.00129344387356067 MirTarget;miRanda -0.0728256158014013 0.00972741768840546 NA NA NA hsa-miR-106a-5p FAS -0.464229535269236 0.009724944358047 -1.01888565147264 1.11378826495697e-07 miRNAWalker2_validate;miRTarBase -0.302797529669468 5.79007536295077e-09 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-21-5p FAS 1.51084295924322 1.54551622173259e-34 -1.01888565147264 1.11378826495697e-07 miRNAWalker2_validate -0.345881974093154 8.950367188801e-07 24710931 miR 21 targets Fas ligand mediated apoptosis in breast cancer cell line MCF 7 breast cancer hsa-miR-338-3p FAS 0.543135607704581 0.00461167747143826 -1.01888565147264 1.11378826495697e-07 miRanda -0.23029320652752 2.57971450360388e-06 NA NA NA hsa-miR-361-5p FAS 0.233202959858696 0.00961572812255327 -1.01888565147264 1.11378826495697e-07 miRanda -0.400344969968845 0.000164688479523076 NA NA NA hsa-miR-590-5p FAS -0.103355559980404 0.310027295317092 -1.01888565147264 1.11378826495697e-07 miRanda -0.564263807321375 1.14802968070722e-09 NA NA NA hsa-miR-98-5p FAS -0.0487189107419432 0.715911066732548 -1.01888565147264 1.11378826495697e-07 miRNAWalker2_validate -0.184416097033268 0.00981276415174906 NA NA NA hsa-miR-25-3p FASLG 0.633062563556379 3.68686354834328e-10 -0.789267794109529 0.000910923617828174 miRNATAP -0.409147266425705 0.000319496225971281 NA NA NA hsa-miR-125a-5p IKBKG -0.91219969372382 1.38256246489548e-07 0.660366120199928 1.71867865546723e-06 miRanda -0.219029418282295 9.51829321882113e-09 NA NA NA hsa-miR-141-3p IKBKG -0.354316381352484 0.256996894288799 0.660366120199928 1.71867865546723e-06 mirMAP -0.0974393657534541 6.84581902241005e-06 NA NA NA hsa-miR-143-3p IKBKG -0.584123869220553 0.000907217687997436 0.660366120199928 1.71867865546723e-06 mirMAP -0.169551761758995 9.09905571393035e-06 NA NA NA hsa-miR-150-5p IKBKG -1.14624309254329 1.51365525978726e-06 0.660366120199928 1.71867865546723e-06 mirMAP -0.0666729206292659 0.0180781295155395 NA NA NA hsa-miR-200a-3p IKBKG -1.49949292595657 3.18410995256133e-05 0.660366120199928 1.71867865546723e-06 mirMAP -0.100439586597671 5.62621816828972e-08 NA NA NA hsa-miR-24-3p IKBKG -0.257825594021966 0.00689742600215061 0.660366120199928 1.71867865546723e-06 mirMAP -0.287544034512102 5.8686253015948e-05 NA NA NA hsa-miR-3065-3p IKBKG -1.04244468016704 4.60743424372577e-05 0.660366120199928 1.71867865546723e-06 mirMAP -0.115721435331344 9.61381024877344e-06 NA NA NA hsa-miR-320a IKBKG 0.325285936317332 0.0221415065838824 0.660366120199928 1.71867865546723e-06 mirMAP -0.182311319218153 0.000133876392194021 NA NA NA hsa-miR-320b IKBKG 0.0919652022571331 0.607981643616945 0.660366120199928 1.71867865546723e-06 mirMAP -0.132285547849802 0.000522961413620221 NA NA NA hsa-miR-330-3p IKBKG -0.332364259424489 0.0316051913061459 0.660366120199928 1.71867865546723e-06 mirMAP -0.111083773167518 0.0137533606676294 NA NA NA hsa-miR-335-5p IKBKG -1.61347836513558 1.62757083289711e-19 0.660366120199928 1.71867865546723e-06 mirMAP -0.273399124951207 9.32430291537739e-15 NA NA NA hsa-miR-338-5p IKBKG -0.221898432884726 0.252390988727086 0.660366120199928 1.71867865546723e-06 mirMAP -0.206675822417303 2.68501101428877e-09 NA NA NA hsa-miR-376c-3p IKBKG -1.78544013329054 1.82972185127691e-10 0.660366120199928 1.71867865546723e-06 mirMAP -0.14083607992738 1.85430800686914e-09 NA NA NA hsa-miR-432-5p IKBKG -0.536178819038888 0.0748623258271085 0.660366120199928 1.71867865546723e-06 mirMAP -0.0893146965360332 7.37173593611945e-05 NA NA NA hsa-miR-485-3p IKBKG -0.429504552347863 0.165399880918286 0.660366120199928 1.71867865546723e-06 mirMAP -0.0726632120289315 0.00101091710544724 NA NA NA hsa-miR-542-3p IKBKG -1.31351015149842 3.64642423288576e-22 0.660366120199928 1.71867865546723e-06 mirMAP -0.292142688932618 4.40119371820177e-10 NA NA NA hsa-miR-17-3p IL1R1 0.410352776142368 0.00422200500748636 -1.01045381057689 4.50684679449702e-13 mirMAP -0.39073755100076 1.02125622521434e-16 NA NA NA hsa-miR-181a-5p IL1R1 0.250113435902954 0.0551933249319293 -1.01045381057689 4.50684679449702e-13 mirMAP -0.2322434157224 1.42776581461954e-05 NA NA NA hsa-miR-181b-5p IL1R1 0.488256489401108 0.00105321129419701 -1.01045381057689 4.50684679449702e-13 mirMAP -0.246016811028355 1.07107101412662e-07 NA NA NA hsa-miR-215-5p IL1R1 -0.981544773246509 3.14452272477156e-05 -1.01045381057689 4.50684679449702e-13 miRNAWalker2_validate -0.0588926017884169 0.0456263823796641 NA NA NA hsa-miR-335-3p IL1R1 -0.275199247483111 0.106629165248783 -1.01045381057689 4.50684679449702e-13 mirMAP -0.101903718478287 0.0132287699838817 NA NA NA hsa-miR-107 IL1RAP 0.241662461253461 0.0170788899505389 -2.2850961688971 4.44698063203837e-31 miRanda -0.250942796121935 0.0151444193925938 NA NA NA hsa-miR-204-5p IL1RAP -0.537962150012103 0.0330895493358849 -2.2850961688971 4.44698063203837e-31 miRNAWalker2_validate -0.102286003710466 0.0127700871788485 NA NA NA hsa-miR-224-3p IL1RAP 1.40770116795301 1.31426607144612e-08 -2.2850961688971 4.44698063203837e-31 MirTarget -0.0884407991634563 0.0340593489374278 NA NA NA hsa-miR-29b-3p IL1RAP -0.348885528720517 0.0121441341291285 -2.2850961688971 4.44698063203837e-31 MirTarget;miRNATAP -0.239343862185629 0.00132489573832657 NA NA NA hsa-miR-362-3p IL1RAP 0.814007335895913 2.00108618836568e-09 -2.2850961688971 4.44698063203837e-31 miRanda -0.183368678865008 0.0148788495482137 NA NA NA hsa-miR-421 IL1RAP 0.941856334694081 6.12167297054077e-08 -2.2850961688971 4.44698063203837e-31 MirTarget;miRanda -0.179170930023216 0.00236521232674224 NA NA NA hsa-miR-93-5p IL1RAP 1.39518349670953 2.84167728726712e-25 -2.2850961688971 4.44698063203837e-31 MirTarget -0.289423051870737 6.58804226779057e-05 NA NA NA hsa-miR-142-3p IRAK1 -1.4243101967815 1.92609481097765e-14 1.21767339008179 3.30121906631099e-23 PITA;miRanda;miRNATAP -0.103953357056079 0.00153955309513343 NA NA NA hsa-miR-146a-5p IRAK1 -0.742958238440575 0.000765983177482633 1.21767339008179 3.30121906631099e-23 miRNAWalker2_validate;miRTarBase -0.0680095323772502 0.0169404448371201 25242818;22846912;21632853 Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;Functional analysis revealed that miR-146a rs2910164 C allele inhibited cell proliferation and significantly downregulated expression of IRAK1 and TRAF6 in bladder cancer cells;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;; pancreatic cancer;bladder cancer;gastric cancer hsa-miR-192-5p IRAK1 -0.50188499512787 0.00344713341196035 1.21767339008179 3.30121906631099e-23 miRNAWalker2_validate -0.076878680025485 0.0367180519385256 NA NA NA hsa-miR-328-3p IRAK1 -0.547466865311955 6.8359574451572e-06 1.21767339008179 3.30121906631099e-23 miRNAWalker2_validate -0.172704549123244 0.000809428396103482 NA NA NA hsa-miR-450b-5p IRAK2 -1.34333360369432 2.68386079790462e-17 0.055768578260591 0.68326196988381 PITA -0.099034422209796 0.0139834536312308 NA NA NA hsa-miR-16-1-3p IRAK3 0.392360028038559 0.00112481918108198 -1.13497721915457 1.79851071172739e-09 mirMAP -0.161489077600316 0.0387474861397117 NA NA NA hsa-miR-188-5p IRAK3 1.11646899351496 9.56686958408598e-11 -1.13497721915457 1.79851071172739e-09 mirMAP -0.158734470858165 0.0029008108464997 NA NA NA hsa-miR-20a-3p IRAK3 -0.318177901603857 0.0467885456739855 -1.13497721915457 1.79851071172739e-09 mirMAP -0.175357327305712 0.00282281922197201 NA NA NA hsa-miR-224-3p IRAK3 1.40770116795301 1.31426607144612e-08 -1.13497721915457 1.79851071172739e-09 mirMAP -0.128614239192543 0.000620367595349101 NA NA NA hsa-miR-25-3p IRAK3 0.633062563556379 3.68686354834328e-10 -1.13497721915457 1.79851071172739e-09 mirMAP -0.496027831935383 4.28679741709112e-08 NA NA NA hsa-miR-32-5p IRAK3 0.0806126674664016 0.548984992497432 -1.13497721915457 1.79851071172739e-09 mirMAP -0.204454930256192 0.00353280923858211 NA NA NA hsa-miR-3200-3p IRAK3 1.40312896232918 1.8232142177606e-07 -1.13497721915457 1.79851071172739e-09 mirMAP -0.144065146663431 5.67390601970441e-05 NA NA NA hsa-miR-324-5p IRAK3 0.372933276649782 0.00592280066108904 -1.13497721915457 1.79851071172739e-09 miRanda -0.190946568884495 0.00586377402152574 NA NA NA hsa-miR-33a-5p IRAK3 -0.767474460958522 1.09948756118522e-05 -1.13497721915457 1.79851071172739e-09 mirMAP -0.167941780649256 0.00159158216708375 NA NA NA hsa-miR-361-5p IRAK3 0.233202959858696 0.00961572812255327 -1.13497721915457 1.79851071172739e-09 miRanda;mirMAP -0.366492329047263 0.000485264246384617 NA NA NA hsa-miR-421 IRAK3 0.941856334694081 6.12167297054077e-08 -1.13497721915457 1.79851071172739e-09 miRanda;mirMAP -0.124481618193916 0.0198048985000042 NA NA NA hsa-miR-452-3p IRAK3 1.76909792952222 2.98172274671408e-10 -1.13497721915457 1.79851071172739e-09 mirMAP -0.112416875181292 0.00056065737846136 NA NA NA hsa-miR-589-3p IRAK3 1.16846704028095 5.88525574424201e-11 -1.13497721915457 1.79851071172739e-09 mirMAP -0.202545194522017 0.000106710303655112 NA NA NA hsa-miR-590-5p IRAK3 -0.103355559980404 0.310027295317092 -1.13497721915457 1.79851071172739e-09 mirMAP -0.236529093934749 0.0111670138712054 NA NA NA hsa-miR-616-5p IRAK3 0.150569904638223 0.402836556304524 -1.13497721915457 1.79851071172739e-09 mirMAP -0.199250897246326 0.000132887689303882 NA NA NA hsa-miR-660-5p IRAK3 0.989755850734071 5.69930767464937e-14 -1.13497721915457 1.79851071172739e-09 mirMAP -0.276330936099034 6.11647347583833e-05 NA NA NA hsa-miR-92a-3p IRAK3 0.212391012518195 0.134292268089997 -1.13497721915457 1.79851071172739e-09 mirMAP -0.289084278502964 1.15719165104441e-05 NA NA NA hsa-miR-30d-3p IRAK4 -0.120562286038759 0.329549534782125 0.0196456384958048 0.750527352134966 mirMAP -0.131118951269709 4.3287196994492e-08 NA NA NA hsa-miR-17-3p MAP3K14 0.410352776142368 0.00422200500748636 -0.256732855579524 0.0805960527428211 MirTarget -0.134473480210187 0.00705656422421302 NA NA NA hsa-miR-17-5p MAP3K14 0.698861147045461 2.43854106455398e-05 -0.256732855579524 0.0805960527428211 MirTarget -0.200236479730088 2.50369988878285e-06 NA NA NA hsa-miR-20a-5p MAP3K14 0.854326758727003 5.04256669663285e-07 -0.256732855579524 0.0805960527428211 MirTarget -0.157807215094265 0.000138930673437178 NA NA NA hsa-miR-331-3p MAP3K14 -0.283974346994635 0.0373785411053202 -0.256732855579524 0.0805960527428211 MirTarget -0.105782868298554 0.044870301619157 NA NA NA hsa-miR-429 MAP3K14 -1.40262535827285 6.93982219171912e-05 -0.256732855579524 0.0805960527428211 miRNATAP -0.0629952478155838 0.00195943778110559 NA NA NA hsa-miR-874-3p MAP3K14 -1.07043026298634 2.09564226589678e-07 -0.256732855579524 0.0805960527428211 MirTarget -0.122908909256529 0.000312223440563301 NA NA NA hsa-miR-93-5p MAP3K14 1.39518349670953 2.84167728726712e-25 -0.256732855579524 0.0805960527428211 MirTarget -0.109806816492741 0.0293044468703522 NA NA NA hsa-miR-330-5p MYD88 0.442231058604099 0.0053308560843808 -1.09504958245187 7.49679043456039e-31 MirTarget;miRanda -0.158294311884371 3.16398911506774e-07 NA NA NA hsa-miR-660-5p MYD88 0.989755850734071 5.69930767464937e-14 -1.09504958245187 7.49679043456039e-31 MirTarget -0.17212659556565 2.27550637162311e-06 NA NA NA hsa-miR-940 MYD88 0.453020092551484 0.0177054921651997 -1.09504958245187 7.49679043456039e-31 miRNATAP -0.0996539434409239 0.000186879064180085 NA NA NA hsa-miR-15a-5p NFKB1 0.349521211668244 0.000770735998804736 -0.538916955748098 1.42993670239858e-08 miRNAWalker2_validate -0.153048958379264 0.000730484492411411 NA NA NA hsa-miR-21-5p NFKB1 1.51084295924322 1.54551622173259e-34 -0.538916955748098 1.42993670239858e-08 miRNAWalker2_validate -0.0802272699480361 0.0227532399564438 19559015 We further identified and validated LRRFIP1 whose product is an inhibitor of NF-kappaB signaling as a direct target gene of miR-21 glioblastoma hsa-miR-338-3p NFKB1 0.543135607704581 0.00461167747143826 -0.538916955748098 1.42993670239858e-08 miRanda -0.0654752431320029 0.00740968011372943 NA NA NA hsa-miR-548j-5p NFKB1 0.251239647701947 0.171361975450222 -0.538916955748098 1.42993670239858e-08 MirTarget -0.106885227436574 4.88574003092244e-05 NA NA NA hsa-miR-671-5p NFKB1 0.843645373345787 3.92794196273313e-08 -0.538916955748098 1.42993670239858e-08 MirTarget -0.0713919721214005 0.0183073022077603 NA NA NA hsa-miR-92a-3p NFKB1 0.212391012518195 0.134292268089997 -0.538916955748098 1.42993670239858e-08 miRNAWalker2_validate -0.147016189975437 8.47280185007855e-06 NA NA NA hsa-miR-423-5p NGF 0.698807775906485 1.02195196334612e-11 -1.13456502234037 7.24473953628721e-08 MirTarget;miRNATAP -0.447502128127762 6.35933337883299e-06 NA NA NA hsa-miR-146b-5p PIK3CA 0.419719546795449 0.0457375823220155 -0.417502897789422 0.000144089141837096 mirMAP -0.0705707099672339 0.00579780514213364 NA NA NA hsa-miR-17-5p PIK3CA 0.698861147045461 2.43854106455398e-05 -0.417502897789422 0.000144089141837096 miRNAWalker2_validate -0.140034439363479 1.22830047865626e-05 NA NA NA hsa-miR-339-5p PIK3CA 0.280589919878422 0.0355660282647215 -0.417502897789422 0.000144089141837096 miRanda -0.161250958910826 6.10867364493006e-05 NA NA NA hsa-miR-501-5p PIK3CA 1.15231083477882 2.98906150004088e-10 -0.417502897789422 0.000144089141837096 mirMAP -0.110297544989421 0.000121810192831398 NA NA NA hsa-miR-126-5p PIK3CB -0.428561469405594 6.6035585844222e-05 0.100967159570933 0.165951003911767 mirMAP -0.182730257201379 1.71015167377407e-08 NA NA NA hsa-miR-130a-3p PIK3CB -1.53229181736223 2.91460363624872e-19 0.100967159570933 0.165951003911767 miRNATAP -0.0557721405046424 0.00476195017411848 NA NA NA hsa-miR-19b-3p PIK3CB 0.601279551368824 0.00016685097085251 0.100967159570933 0.165951003911767 miRNATAP -0.0535798502737107 0.0149108720105704 NA NA NA hsa-miR-204-5p PIK3CB -0.537962150012103 0.0330895493358849 0.100967159570933 0.165951003911767 miRNATAP -0.108408817404481 9.83805003133513e-16 NA NA NA hsa-miR-29b-3p PIK3CB -0.348885528720517 0.0121441341291285 0.100967159570933 0.165951003911767 miRNATAP -0.0588366745720603 0.0207378050705187 NA NA NA hsa-miR-32-5p PIK3CB 0.0806126674664016 0.548984992497432 0.100967159570933 0.165951003911767 miRNATAP -0.140663620385439 6.63155819716864e-08 NA NA NA hsa-miR-455-5p PIK3CB -0.270546034117157 0.0581320703577731 0.100967159570933 0.165951003911767 miRNATAP -0.080179445670719 0.00119153487897199 NA NA NA hsa-miR-1468-5p PIK3CD -1.21475558175193 2.52286949987832e-09 -0.877858532886072 2.39332269929579e-06 MirTarget -0.114605918546385 0.00956114952826845 NA NA NA hsa-miR-30b-3p PIK3CD -0.439724365151373 0.000947180503583586 -0.877858532886072 2.39332269929579e-06 MirTarget -0.241027174305288 0.000454965508091255 NA NA NA hsa-miR-30d-5p PIK3CD 0.718283816348023 2.47422074061352e-08 -0.877858532886072 2.39332269929579e-06 MirTarget;miRNATAP -0.313277633599958 7.26196135533465e-06 NA NA NA hsa-miR-30e-5p PIK3CD -0.627815042856657 3.02205690184908e-10 -0.877858532886072 2.39332269929579e-06 MirTarget -0.253648851782905 0.00528999528593308 NA NA NA hsa-miR-616-5p PIK3CD 0.150569904638223 0.402836556304524 -0.877858532886072 2.39332269929579e-06 MirTarget -0.206581353665342 5.02538338243613e-05 NA NA NA hsa-miR-103a-3p PIK3R1 0.765568928457606 3.05497476509383e-12 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.187692597616198 0.00702590214654354 NA NA NA hsa-miR-106a-5p PIK3R1 -0.464229535269236 0.009724944358047 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.0982737289984491 0.0235183151126322 NA NA NA hsa-miR-106b-5p PIK3R1 0.648901865047099 8.24870862047885e-09 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.369244291882445 4.59379549667075e-08 NA NA NA hsa-miR-127-5p PIK3R1 -1.30084454872193 2.78105401208939e-07 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.082467649275574 0.00650772536236468 24004856 Integrated gene network analysis and text mining revealing PIK3R1 regulated by miR 127 in human bladder cancer; These findings provide new insights into the role of miRNAs in the pathway of cancer and give us a hypothesis that miR-127 might play a similar role in regulation and control of PIK3R1 bladder cancer hsa-miR-1301-3p PIK3R1 1.12156714169769 4.22404125385203e-10 -0.891953424131491 1.38465728969785e-08 MirTarget -0.26088137729301 3.97606431390706e-10 NA NA NA hsa-miR-132-3p PIK3R1 0.323796239695997 0.00272093067935091 -0.891953424131491 1.38465728969785e-08 MirTarget -0.517351445825174 2.17222827385203e-13 NA NA NA hsa-miR-15b-5p PIK3R1 0.230566941413564 0.0824765001857479 -0.891953424131491 1.38465728969785e-08 MirTarget -0.132325827339178 0.0249531550846148 NA NA NA hsa-miR-17-5p PIK3R1 0.698861147045461 2.43854106455398e-05 -0.891953424131491 1.38465728969785e-08 MirTarget;TargetScan;miRNATAP -0.213954808771155 3.8587060059728e-06 NA NA NA hsa-miR-182-5p PIK3R1 1.96601340710222 4.39326175603633e-09 -0.891953424131491 1.38465728969785e-08 miRNATAP -0.0986527592010262 1.29353935955712e-05 NA NA NA hsa-miR-185-5p PIK3R1 0.480006257154717 6.35758891340152e-07 -0.891953424131491 1.38465728969785e-08 miRNATAP -0.255181123475439 0.00153792085091181 NA NA NA hsa-miR-188-5p PIK3R1 1.11646899351496 9.56686958408598e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.178093775716465 5.33015486626271e-05 NA NA NA hsa-miR-199b-5p PIK3R1 -0.454049170125872 0.254611775331658 -0.891953424131491 1.38465728969785e-08 miRanda -0.0854140749213787 1.50335576769902e-05 NA NA NA hsa-miR-200b-3p PIK3R1 -1.29335788099229 0.000268623234305059 -0.891953424131491 1.38465728969785e-08 mirMAP -0.0940312429851893 1.36062054763255e-05 NA NA NA hsa-miR-200c-3p PIK3R1 -0.104675615392797 0.716957669484981 -0.891953424131491 1.38465728969785e-08 mirMAP -0.105107802462856 9.06963579759966e-05 NA NA NA hsa-miR-20a-5p PIK3R1 0.854326758727003 5.04256669663285e-07 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.137431012149634 0.00237710222818209 NA NA NA hsa-miR-21-5p PIK3R1 1.51084295924322 1.54551622173259e-34 -0.891953424131491 1.38465728969785e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.626634426633867 6.01244523464713e-31 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 -0.288359631986802 0.100392159518997 -0.891953424131491 1.38465728969785e-08 MirTarget -0.258090192317157 3.95293509038579e-09 NA NA NA hsa-miR-218-5p PIK3R1 -0.500091158894849 0.0398595700240766 -0.891953424131491 1.38465728969785e-08 miRNATAP -0.0821496473403704 0.0101915822718827 NA NA NA hsa-miR-221-3p PIK3R1 1.12244756358612 3.48370308238012e-13 -0.891953424131491 1.38465728969785e-08 MirTarget -0.217914846238424 7.87055620620445e-06 NA NA NA hsa-miR-222-3p PIK3R1 1.08574156066353 1.76407192348131e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.256619417997498 3.41697791848384e-08 NA NA NA hsa-miR-324-3p PIK3R1 0.260348469146494 0.0506141704203545 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.281792149179102 1.26555231509763e-06 NA NA NA hsa-miR-330-3p PIK3R1 -0.332364259424489 0.0316051913061459 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.212492102885122 3.44445995574159e-05 NA NA NA hsa-miR-338-5p PIK3R1 -0.221898432884726 0.252390988727086 -0.891953424131491 1.38465728969785e-08 PITA -0.143685656767977 0.000366657184559181 NA NA NA hsa-miR-369-3p PIK3R1 -0.680843625018478 0.0155063508282041 -0.891953424131491 1.38465728969785e-08 PITA -0.089106605347128 0.00123875833687836 NA NA NA hsa-miR-409-3p PIK3R1 -0.499649792570937 0.0526751181520117 -0.891953424131491 1.38465728969785e-08 mirMAP -0.110448878014769 0.000237041711390918 NA NA NA hsa-miR-429 PIK3R1 -1.40262535827285 6.93982219171912e-05 -0.891953424131491 1.38465728969785e-08 mirMAP;miRNATAP -0.0823845821721242 0.000191840785054079 NA NA NA hsa-miR-485-3p PIK3R1 -0.429504552347863 0.165399880918286 -0.891953424131491 1.38465728969785e-08 mirMAP -0.0935063733862006 0.000215693380621432 NA NA NA hsa-miR-493-5p PIK3R1 -0.198321662045422 0.502870277689198 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.103739426368655 7.76271840065789e-05 NA NA NA hsa-miR-495-3p PIK3R1 -0.751193061269953 0.00388779118736635 -0.891953424131491 1.38465728969785e-08 mirMAP -0.0984259069961719 0.000966260155906194 NA NA NA hsa-miR-582-5p PIK3R1 -0.680189083316822 0.00103755166534107 -0.891953424131491 1.38465728969785e-08 mirMAP -0.138461163257927 0.00021364752999012 NA NA NA hsa-miR-589-3p PIK3R1 1.16846704028095 5.88525574424201e-11 -0.891953424131491 1.38465728969785e-08 mirMAP -0.21021578613876 1.13421126603334e-06 NA NA NA hsa-miR-590-5p PIK3R1 -0.103355559980404 0.310027295317092 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRanda;miRNATAP -0.299776876388425 9.9413226282672e-05 NA NA NA hsa-miR-629-3p PIK3R1 -0.315338123880353 0.119091248294946 -0.891953424131491 1.38465728969785e-08 MirTarget -0.182940394280375 3.19896248240917e-06 NA NA NA hsa-miR-654-3p PIK3R1 -1.72200544726291 6.91948971554614e-10 -0.891953424131491 1.38465728969785e-08 mirMAP -0.0649398048756921 0.0174409600401504 NA NA NA hsa-miR-93-5p PIK3R1 1.39518349670953 2.84167728726712e-25 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.319783065556515 2.89613370212511e-09 NA NA NA hsa-miR-126-3p PIK3R2 -0.652349350198172 9.37876280344772e-09 0.902461657566753 1.95242785807378e-14 miRNAWalker2_validate;miRTarBase -0.307009584408785 1.4469316595199e-09 25240815;26384552;27578985;21249429;26191164 MiR 126 3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2; LRP6 and PIK3R2 were identified as targets of miR-126-3p; Silencing LRP6 and PIK3R2 had similar effects of miR-126-3p restoration on metastasis and angiogenesis individually in HCC cells; Furthermore the miR-126-3p level was inversely correlated with LRP6 and PIK3R2 in HCC tissues; In addition the rescue experiments indicated that the metastasis and angiogenesis functions of miR-126-3p were mediated by LRP6 and PIK3R2;MicroRNA 126 suppresses proliferation of undifferentiated BRAFV600E and BRAFWT thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K AKT proliferation survival signalling pathway; In addition miR-126 was found to act as proliferation suppressor targeting PIK3R2 gene and reducing p85β a regulatory subunit of PI3K kinase protein translation and lower AKT kinase activity;MiR 126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2 mediated PI3K/Akt signaling pathway; A direct regulatory relationship between miR-126 and the PIK3R2 gene was demonstrated by luciferase reporter assays; Quantitative real-time polymerase chain reaction was used to measure miR-126 and PIK3R2 expressions; Luciferase assays showed that miR-126 significantly inhibited the PIK3R2 3' untranslated region 3'UTR luciferase reporter activity P<0.05; Overexpression of miR-126 negatively regulated the target gene PIK3R2 and further inhibited the PI3K/Akt signaling pathway thereby inhibiting proliferation migration and invasion and promoting apoptosis in BLS cells;Endothelial specific intron derived miR 126 is down regulated in human breast cancer and targets both VEGFA and PIK3R2; VEGFA and PIK3R2 were confirmed as the targets of miR-126 by luciferase reporter assay and Western blot;Restoration of miR-126 in EC109 cells induced a reduction in PIK3R2 protein levels accompanied with a substantial reduction in phosphorylated AKT levels in EC109 cells suggesting impairment in PI3K/AKT signaling pathway; The luciferase reporter assay confirmed that PIK3R2 was a direct target of miR-126; Taken together our study suggests that miR-126 functions as a potential tumor suppressor in ESCC progression via regulating PI3K/AKT signaling pathway partly by targeting PIK3R2 and targeting of miR-126 may provide a novel strategy for the diagnosis and treatment of ESCC metastasis;poor survival;;;progression liver cancer;thyroid cancer;bladder cancer;breast cancer;esophageal cancer hsa-miR-28-5p PIK3R2 -0.430964830599964 2.67367257252925e-06 0.902461657566753 1.95242785807378e-14 miRanda -0.216513318430191 0.000794318920407844 NA NA NA hsa-miR-30a-5p PIK3R2 -0.626257932887855 0.000108198196973765 0.902461657566753 1.95242785807378e-14 miRNATAP -0.144672134574065 6.66511974688791e-05 NA NA NA hsa-miR-30e-5p PIK3R2 -0.627815042856657 3.02205690184908e-10 0.902461657566753 1.95242785807378e-14 miRNATAP -0.27051427660089 3.48529317139267e-06 NA NA NA hsa-miR-3607-3p PIK3R2 -2.15518588554493 1.03390728226728e-23 0.902461657566753 1.95242785807378e-14 mirMAP;miRNATAP -0.192639313478842 2.68262287342929e-14 NA NA NA hsa-miR-491-5p PIK3R2 -0.369122930844418 0.0154047757048929 0.902461657566753 1.95242785807378e-14 miRanda -0.091906871679206 0.019577328105005 NA NA NA hsa-miR-1271-5p PIK3R3 -1.00001044718608 1.30308965099272e-09 0.635454203069077 2.81455381573105e-08 mirMAP -0.0859452849667059 0.0114922469281715 NA NA NA hsa-miR-136-5p PIK3R3 -1.19235933727542 1.43089181604509e-05 0.635454203069077 2.81455381573105e-08 mirMAP -0.077935525413091 0.000124746692907377 NA NA NA hsa-miR-19a-3p PIK3R3 1.01712596153672 2.57753201450625e-07 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.104972668125809 0.000194207587349022 NA NA NA hsa-miR-19b-3p PIK3R3 0.601279551368824 0.00016685097085251 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.156884173334155 7.42851910353984e-06 NA NA NA hsa-miR-222-5p PIK3R3 0.125716360553359 0.487423909991138 0.635454203069077 2.81455381573105e-08 mirMAP -0.124074211713995 7.25281139850942e-05 NA NA NA hsa-miR-26b-5p PIK3R3 -1.10804856399744 4.14176110314282e-22 0.635454203069077 2.81455381573105e-08 miRNATAP -0.11879971388214 0.0117895234047857 NA NA NA hsa-miR-32-5p PIK3R3 0.0806126674664016 0.548984992497432 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.115094122727672 0.00654760226880116 NA NA NA hsa-miR-323a-3p PIK3R3 -1.32152926898185 6.70089501458627e-05 0.635454203069077 2.81455381573105e-08 mirMAP -0.0889684652352593 1.55351903240348e-07 NA NA NA hsa-miR-331-3p PIK3R3 -0.283974346994635 0.0373785411053202 0.635454203069077 2.81455381573105e-08 miRNAWalker2_validate;PITA -0.141431444954819 0.000659359723681179 NA NA NA hsa-miR-335-3p PIK3R3 -0.275199247483111 0.106629165248783 0.635454203069077 2.81455381573105e-08 mirMAP -0.159933987443154 1.18680673169693e-06 NA NA NA hsa-miR-369-3p PIK3R3 -0.680843625018478 0.0155063508282041 0.635454203069077 2.81455381573105e-08 PITA -0.0815705912071776 4.42306083374931e-05 NA NA NA hsa-miR-375 PIK3R3 -1.93190458972328 4.28108492522e-06 0.635454203069077 2.81455381573105e-08 miRanda -0.054322182765339 3.95692040823736e-05 NA NA NA hsa-miR-381-3p PIK3R3 -1.11307533852141 4.70760087251745e-06 0.635454203069077 2.81455381573105e-08 mirMAP -0.0844597632072644 0.000229250379656187 NA NA NA hsa-miR-382-5p PIK3R3 -0.71884748690977 0.00849172229801356 0.635454203069077 2.81455381573105e-08 mirMAP -0.0661933547819628 0.00131896415966583 NA NA NA hsa-miR-421 PIK3R3 0.941856334694081 6.12167297054077e-08 0.635454203069077 2.81455381573105e-08 mirMAP -0.086158661725359 0.0074768171222283 NA NA NA hsa-miR-429 PIK3R3 -1.40262535827285 6.93982219171912e-05 0.635454203069077 2.81455381573105e-08 miRNATAP -0.0980950241616801 5.60474977030741e-10 NA NA NA hsa-miR-432-5p PIK3R3 -0.536178819038888 0.0748623258271085 0.635454203069077 2.81455381573105e-08 MirTarget -0.0670632918517256 0.00035707492420589 NA NA NA hsa-miR-454-3p PIK3R3 0.668749059573955 2.42670710515113e-06 0.635454203069077 2.81455381573105e-08 mirMAP -0.155284428603942 8.0835303918136e-05 NA NA NA hsa-miR-485-3p PIK3R3 -0.429504552347863 0.165399880918286 0.635454203069077 2.81455381573105e-08 PITA -0.0715914581227065 9.53806239164876e-05 NA NA NA hsa-miR-495-3p PIK3R3 -0.751193061269953 0.00388779118736635 0.635454203069077 2.81455381573105e-08 mirMAP -0.0735361063134819 0.00068750747635853 NA NA NA hsa-miR-589-3p PIK3R3 1.16846704028095 5.88525574424201e-11 0.635454203069077 2.81455381573105e-08 mirMAP -0.0712458611408378 0.0247769463089986 NA NA NA hsa-miR-590-5p PIK3R3 -0.103355559980404 0.310027295317092 0.635454203069077 2.81455381573105e-08 miRanda -0.243402254613955 1.30668545381547e-05 NA NA NA hsa-miR-624-5p PIK3R3 -0.639533773668123 6.79146620944254e-06 0.635454203069077 2.81455381573105e-08 MirTarget -0.124942360560089 0.00156005977445166 NA NA NA hsa-miR-654-3p PIK3R3 -1.72200544726291 6.91948971554614e-10 0.635454203069077 2.81455381573105e-08 PITA;miRNATAP -0.0740087653748546 0.000178756572011336 NA NA NA hsa-miR-92a-3p PIK3R3 0.212391012518195 0.134292268089997 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.21036606255577 1.06004328001549e-07 NA NA NA hsa-miR-107 PIK3R5 0.241662461253461 0.0170788899505389 -0.89989526759384 1.62789758196776e-07 miRanda -0.349504238477674 3.20976138937126e-05 NA NA NA hsa-miR-106b-5p PPP3CA 0.648901865047099 8.24870862047885e-09 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.191067063648852 3.69747843513626e-08 NA NA NA hsa-miR-17-3p PPP3CA 0.410352776142368 0.00422200500748636 -0.536165287387848 2.77787023947662e-11 MirTarget -0.148715997251777 6.8452735631761e-08 NA NA NA hsa-miR-17-5p PPP3CA 0.698861147045461 2.43854106455398e-05 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.143640408234319 1.13035407609444e-09 NA NA NA hsa-miR-194-5p PPP3CA -0.292530160992458 0.0996141384876663 -0.536165287387848 2.77787023947662e-11 MirTarget -0.0951221882472376 2.21503653912702e-05 NA NA NA hsa-miR-20a-5p PPP3CA 0.854326758727003 5.04256669663285e-07 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.13596145796804 2.84983869383186e-09 NA NA NA hsa-miR-21-5p PPP3CA 1.51084295924322 1.54551622173259e-34 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.143821297395015 1.2695170248385e-06 NA NA NA hsa-miR-30d-5p PPP3CA 0.718283816348023 2.47422074061352e-08 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.146138892286555 1.56191209956503e-06 NA NA NA hsa-miR-361-3p PPP3CA 0.275658012727111 0.00549374744374488 -0.536165287387848 2.77787023947662e-11 MirTarget;PITA;miRNATAP -0.0919525272856204 0.0238831730737908 NA NA NA hsa-miR-361-5p PPP3CA 0.233202959858696 0.00961572812255327 -0.536165287387848 2.77787023947662e-11 miRanda -0.145335005010698 0.00120607782460008 NA NA NA hsa-miR-501-3p PPP3CA 0.999540908940094 2.77358485581974e-11 -0.536165287387848 2.77787023947662e-11 MirTarget;PITA;miRNATAP -0.169069809996199 3.5765991379194e-11 NA NA NA hsa-miR-502-3p PPP3CA 0.659598854007546 3.01316453996423e-08 -0.536165287387848 2.77787023947662e-11 MirTarget;PITA;miRNATAP -0.21026132041502 1.15384439121552e-10 NA NA NA hsa-miR-589-3p PPP3CA 1.16846704028095 5.88525574424201e-11 -0.536165287387848 2.77787023947662e-11 MirTarget -0.121264895830011 4.18270966031286e-08 NA NA NA hsa-miR-616-5p PPP3CA 0.150569904638223 0.402836556304524 -0.536165287387848 2.77787023947662e-11 MirTarget;mirMAP;miRNATAP -0.0586848954529343 0.0086895794284173 NA NA NA hsa-miR-93-3p PPP3CA 0.402821129107592 0.00131324842735588 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.143288165599429 6.27730698290466e-06 NA NA NA hsa-miR-93-5p PPP3CA 1.39518349670953 2.84167728726712e-25 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.206462809599041 4.19505348801646e-14 NA NA NA hsa-miR-15b-5p PPP3CB 0.230566941413564 0.0824765001857479 0.0031491477510821 0.959395186445486 miRNATAP -0.0671844336033451 0.00288147358643986 NA NA NA hsa-miR-195-5p PPP3CB -1.85907534356434 1.47434041676402e-22 0.0031491477510821 0.959395186445486 miRNATAP -0.0557614325521116 0.00016451116344865 NA NA NA hsa-miR-497-5p PPP3CB -1.41371173021948 7.09278946477743e-17 0.0031491477510821 0.959395186445486 miRNATAP -0.0560672647195707 0.000918522991241513 NA NA NA hsa-miR-361-5p PPP3CC 0.233202959858696 0.00961572812255327 -0.442598423475551 4.06646193924103e-07 miRanda -0.159719077024821 0.00091909551904825 NA NA NA hsa-miR-106b-5p PPP3R1 0.648901865047099 8.24870862047885e-09 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.138661227962938 5.82082557526804e-07 NA NA NA hsa-miR-143-5p PPP3R1 -0.42696209881145 0.00646356677356831 -0.348267739030591 8.30932335829799e-08 miRNATAP -0.0739999145226298 0.000261938332297629 NA NA NA hsa-miR-17-5p PPP3R1 0.698861147045461 2.43854106455398e-05 -0.348267739030591 8.30932335829799e-08 MirTarget;TargetScan;miRNATAP -0.0968185219023474 3.09438896649476e-07 NA NA NA hsa-miR-181a-5p PPP3R1 0.250113435902954 0.0551933249319293 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.13691462952235 1.55708164198961e-08 NA NA NA hsa-miR-181b-5p PPP3R1 0.488256489401108 0.00105321129419701 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.13726473522507 5.36198845965272e-11 NA NA NA hsa-miR-181c-5p PPP3R1 -0.00639394152050299 0.969127212255928 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.116625763794141 9.00795108119744e-10 NA NA NA hsa-miR-181d-5p PPP3R1 0.161600964883517 0.363806828762999 -0.348267739030591 8.30932335829799e-08 MirTarget -0.0957831346739969 6.70374423639183e-08 NA NA NA hsa-miR-183-5p PPP3R1 2.33444328833177 1.52188109365421e-10 -0.348267739030591 8.30932335829799e-08 miRNAWalker2_validate -0.0502145705564118 2.21703589653628e-09 NA NA NA hsa-miR-188-5p PPP3R1 1.11646899351496 9.56686958408598e-11 -0.348267739030591 8.30932335829799e-08 MirTarget -0.0669022010936995 0.000215592543727375 NA NA NA hsa-miR-20a-5p PPP3R1 0.854326758727003 5.04256669663285e-07 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.0750627391877846 4.70951337426413e-05 NA NA NA hsa-miR-221-3p PPP3R1 1.12244756358612 3.48370308238012e-13 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.0689728717566988 0.000589590392167572 NA NA NA hsa-miR-222-3p PPP3R1 1.08574156066353 1.76407192348131e-11 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.081556564949268 2.13269526111146e-05 NA NA NA hsa-miR-24-3p PPP3R1 -0.257825594021966 0.00689742600215061 -0.348267739030591 8.30932335829799e-08 miRNAWalker2_validate -0.106343408108425 0.00160055709787487 NA NA NA hsa-miR-27a-3p PPP3R1 -0.370807380415112 0.00875721956202713 -0.348267739030591 8.30932335829799e-08 miRNATAP -0.117734120643401 1.31409589262749e-07 NA NA NA hsa-miR-335-3p PPP3R1 -0.275199247483111 0.106629165248783 -0.348267739030591 8.30932335829799e-08 mirMAP -0.0757782850012068 4.78120826483068e-05 NA NA NA hsa-miR-342-3p PPP3R1 -0.319677314984262 0.0449813878317147 -0.348267739030591 8.30932335829799e-08 MirTarget;miRanda;miRNATAP -0.0704092653948521 0.00042517937715595 NA NA NA hsa-miR-501-3p PPP3R1 0.999540908940094 2.77358485581974e-11 -0.348267739030591 8.30932335829799e-08 miRNATAP -0.0891356710739295 1.59619277052464e-05 NA NA NA hsa-miR-93-5p PPP3R1 1.39518349670953 2.84167728726712e-25 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.108796059262154 9.63915967695639e-07 NA NA NA hsa-miR-940 PPP3R1 0.453020092551484 0.0177054921651997 -0.348267739030591 8.30932335829799e-08 PITA;miRNATAP -0.0531977846065401 0.00193668428946248 NA NA NA hsa-miR-130b-5p PRKACA 0.170599813152408 0.337611586432771 -0.366734298281574 0.000187937709098459 mirMAP;miRNATAP -0.0793799179365961 0.00332914510753435 NA NA NA hsa-miR-146b-5p PRKACA 0.419719546795449 0.0457375823220155 -0.366734298281574 0.000187937709098459 PITA -0.057343954331151 0.0121275820045138 NA NA NA hsa-miR-149-5p PRKACA -0.317176971910036 0.187207559733877 -0.366734298281574 0.000187937709098459 miRNATAP -0.0675996798257149 0.00073873817676034 NA NA NA hsa-miR-15b-5p PRKACA 0.230566941413564 0.0824765001857479 -0.366734298281574 0.000187937709098459 miRNATAP -0.152941432259851 2.28347891457603e-05 NA NA NA hsa-miR-374b-3p PRKACA -0.137420230218985 0.305318192448799 -0.366734298281574 0.000187937709098459 mirMAP -0.12450872310223 0.000539430321626312 NA NA NA hsa-miR-744-5p PRKACA -0.378868377317939 0.00125071229180016 -0.366734298281574 0.000187937709098459 miRNAWalker2_validate -0.115884324772662 0.0046979329289167 NA NA NA hsa-miR-141-3p PRKACB -0.354316381352484 0.256996894288799 -0.439902334736784 5.50105175875769e-05 MirTarget;TargetScan;miRNATAP -0.0651950629200043 0.000135754538441936 NA NA NA hsa-miR-17-5p PRKACB 0.698861147045461 2.43854106455398e-05 -0.439902334736784 5.50105175875769e-05 TargetScan -0.144472658686219 5.56449338176546e-06 NA NA NA hsa-miR-182-5p PRKACB 1.96601340710222 4.39326175603633e-09 -0.439902334736784 5.50105175875769e-05 MirTarget;miRNATAP -0.0730042914396799 2.4635172219541e-06 NA NA NA hsa-miR-183-5p PRKACB 2.33444328833177 1.52188109365421e-10 -0.439902334736784 5.50105175875769e-05 MirTarget -0.0789171507427253 2.20855999324772e-08 NA NA NA hsa-miR-18a-5p PRKACB 0.918028187958706 1.90229510425322e-05 -0.439902334736784 5.50105175875769e-05 miRNATAP -0.0987396771615261 5.73492803459173e-05 NA NA NA hsa-miR-193a-3p PRKACB -0.117675551589896 0.309391958208578 -0.439902334736784 5.50105175875769e-05 miRanda -0.138772633279135 0.00285551569786557 NA NA NA hsa-miR-19a-3p PRKACB 1.01712596153672 2.57753201450625e-07 -0.439902334736784 5.50105175875769e-05 MirTarget;miRNATAP -0.086337572343887 0.00120272587593157 NA NA NA hsa-miR-19b-3p PRKACB 0.601279551368824 0.00016685097085251 -0.439902334736784 5.50105175875769e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.115986971473871 0.00048141723506022 NA NA NA hsa-miR-200a-3p PRKACB -1.49949292595657 3.18410995256133e-05 -0.439902334736784 5.50105175875769e-05 MirTarget;miRNATAP -0.0760218893087077 1.77479536401051e-07 NA NA NA hsa-miR-200b-3p PRKACB -1.29335788099229 0.000268623234305059 -0.439902334736784 5.50105175875769e-05 MirTarget;TargetScan -0.0781383049930156 1.18686460814441e-07 NA NA NA hsa-miR-200c-3p PRKACB -0.104675615392797 0.716957669484981 -0.439902334736784 5.50105175875769e-05 MirTarget;miRNATAP -0.0744003692144122 5.3618974829295e-05 NA NA NA hsa-miR-339-5p PRKACB 0.280589919878422 0.0355660282647215 -0.439902334736784 5.50105175875769e-05 miRanda -0.0825020804987786 0.0404941291442345 NA NA NA hsa-miR-429 PRKACB -1.40262535827285 6.93982219171912e-05 -0.439902334736784 5.50105175875769e-05 MirTarget;PITA;miRanda;miRNATAP -0.0841434611810318 2.04504821439335e-08 NA NA NA hsa-miR-93-5p PRKACB 1.39518349670953 2.84167728726712e-25 -0.439902334736784 5.50105175875769e-05 miRNAWalker2_validate -0.135496406586043 0.000297518311204663 NA NA NA hsa-miR-141-3p PRKAR1A -0.354316381352484 0.256996894288799 -0.221339462064076 0.0226218115406206 TargetScan -0.0728882848234903 1.20841107814403e-06 NA NA NA hsa-miR-150-5p PRKAR1A -1.14624309254329 1.51365525978726e-06 -0.221339462064076 0.0226218115406206 miRNATAP -0.0877819551183233 6.154303418397e-06 NA NA NA hsa-miR-155-5p PRKAR1A 0.0108524225071784 0.95651331033505 -0.221339462064076 0.0226218115406206 miRNAWalker2_validate -0.114318738366975 1.21359964338562e-06 NA NA NA hsa-miR-16-2-3p PRKAR1A -0.0336420826463706 0.805158952566973 -0.221339462064076 0.0226218115406206 mirMAP -0.132953751905959 0.00012681215248748 NA NA NA hsa-miR-182-5p PRKAR1A 1.96601340710222 4.39326175603633e-09 -0.221339462064076 0.0226218115406206 miRNATAP -0.0555618273465369 5.25526613763808e-05 NA NA NA hsa-miR-195-3p PRKAR1A -1.09375690196245 4.70092324819807e-09 -0.221339462064076 0.0226218115406206 mirMAP -0.0894819403435157 0.000363972795279819 NA NA NA hsa-miR-25-3p PRKAR1A 0.633062563556379 3.68686354834328e-10 -0.221339462064076 0.0226218115406206 miRNAWalker2_validate -0.106494004961097 0.0213899716260691 NA NA NA hsa-miR-320a PRKAR1A 0.325285936317332 0.0221415065838824 -0.221339462064076 0.0226218115406206 miRanda -0.0658140486640576 0.0485722082418309 NA NA NA hsa-miR-320b PRKAR1A 0.0919652022571331 0.607981643616945 -0.221339462064076 0.0226218115406206 miRanda -0.0585469048770488 0.0277539413325938 NA NA NA hsa-miR-324-3p PRKAR1A 0.260348469146494 0.0506141704203545 -0.221339462064076 0.0226218115406206 miRNAWalker2_validate -0.117454830748043 0.000948511276308163 NA NA NA hsa-miR-342-3p PRKAR1A -0.319677314984262 0.0449813878317147 -0.221339462064076 0.0226218115406206 miRanda -0.153816133332965 1.54784561086563e-07 NA NA NA hsa-miR-590-5p PRKAR1A -0.103355559980404 0.310027295317092 -0.221339462064076 0.0226218115406206 miRanda -0.10589962493971 0.0242194958189026 NA NA NA hsa-miR-155-5p PRKAR2A 0.0108524225071784 0.95651331033505 -0.445956894636509 0.039701655854281 miRNAWalker2_validate -0.109943534691235 0.039319351819679 NA NA NA hsa-miR-17-5p PRKAR2A 0.698861147045461 2.43854106455398e-05 -0.445956894636509 0.039701655854281 mirMAP -0.197176558926379 0.00184983862328776 NA NA NA hsa-miR-182-5p PRKAR2A 1.96601340710222 4.39326175603633e-09 -0.445956894636509 0.039701655854281 mirMAP -0.0621644469555247 0.0448607293148599 NA NA NA hsa-miR-20a-5p PRKAR2A 0.854326758727003 5.04256669663285e-07 -0.445956894636509 0.039701655854281 mirMAP -0.144423440498608 0.0189487099139109 NA NA NA hsa-miR-21-5p PRKAR2A 1.51084295924322 1.54551622173259e-34 -0.445956894636509 0.039701655854281 mirMAP -0.324627317167112 3.73345274692546e-05 NA NA NA hsa-miR-330-3p PRKAR2A -0.332364259424489 0.0316051913061459 -0.445956894636509 0.039701655854281 mirMAP -0.212639809934197 0.00237969257187532 NA NA NA hsa-miR-330-5p PRKAR2A 0.442231058604099 0.0053308560843808 -0.445956894636509 0.039701655854281 miRanda -0.146631544169208 0.0279152956985126 NA NA NA hsa-miR-766-3p PRKAR2A 0.199979324759329 0.257230732626744 -0.445956894636509 0.039701655854281 mirMAP -0.12476771309893 0.0380902352945277 NA NA NA hsa-miR-769-3p PRKAR2A 0.618139013155289 0.000147293288426878 -0.445956894636509 0.039701655854281 miRNAWalker2_validate -0.1775777282247 0.00738096929492439 NA NA NA hsa-miR-92b-3p PRKAR2A 0.220374930803974 0.296187538889092 -0.445956894636509 0.039701655854281 mirMAP -0.107950929856527 0.0317503273530871 NA NA NA hsa-miR-107 PRKAR2B 0.241662461253461 0.0170788899505389 -2.84864349816651 1.88295295481915e-25 miRanda -0.526935700945379 0.000176603848469258 NA NA NA hsa-miR-32-5p PRKAR2B 0.0806126674664016 0.548984992497432 -2.84864349816651 1.88295295481915e-25 miRNATAP -0.401821346272686 0.000140234241165594 NA NA NA hsa-miR-362-3p PRKAR2B 0.814007335895913 2.00108618836568e-09 -2.84864349816651 1.88295295481915e-25 miRanda -0.308186223710963 0.00269517694271484 NA NA NA hsa-miR-452-5p PRKAR2B 1.91544498799508 1.81995982853313e-14 -2.84864349816651 1.88295295481915e-25 miRNATAP -0.226491062848928 3.22037962571609e-05 NA NA NA hsa-miR-128-3p PRKX 0.289735108018712 0.0114419474207889 -0.240211607134995 0.240371070351319 MirTarget -0.177065931374921 0.0432124195545335 NA NA NA hsa-miR-140-3p PRKX 0.546012239205329 4.84578261098777e-11 -0.240211607134995 0.240371070351319 mirMAP -0.414153706871003 0.000486275257531284 NA NA NA hsa-miR-148a-3p PRKX -0.748702855596996 3.93313343865641e-07 -0.240211607134995 0.240371070351319 MirTarget -0.590431480469924 2.08013051455884e-20 NA NA NA hsa-miR-16-1-3p PRKX 0.392360028038559 0.00112481918108198 -0.240211607134995 0.240371070351319 MirTarget -0.244568911489674 0.00313195084634789 NA NA NA hsa-miR-23b-3p PRKX -0.530561587109023 5.43807206823652e-07 -0.240211607134995 0.240371070351319 mirMAP -0.336626794798551 0.000311507204483922 NA NA NA hsa-miR-26b-3p PRKX -1.25503731613309 4.45390890119649e-27 -0.240211607134995 0.240371070351319 mirMAP -0.22275165341533 0.00569151212175373 NA NA NA hsa-miR-33a-5p PRKX -0.767474460958522 1.09948756118522e-05 -0.240211607134995 0.240371070351319 mirMAP -0.202109755439834 0.000339503602376678 NA NA NA hsa-miR-33b-5p PRKX -2.28852395459234 2.69046626645242e-22 -0.240211607134995 0.240371070351319 mirMAP -0.0910154182275712 0.0242733999483607 NA NA NA hsa-miR-374a-3p PRKX -0.207171354826929 0.0623494608399903 -0.240211607134995 0.240371070351319 mirMAP -0.334277813432835 0.000202864124975447 NA NA NA hsa-miR-576-5p PRKX -0.377452008285847 0.00470735657343984 -0.240211607134995 0.240371070351319 mirMAP -0.216716249090268 0.00370148195253601 NA NA NA hsa-miR-125a-3p RIPK1 -0.841683158494395 3.51202687176603e-05 -0.188124658177485 0.00314321575757941 miRanda -0.0817075013322314 7.9113092375883e-08 NA NA NA hsa-miR-21-3p RIPK1 -0.484219378716006 0.00299941098417659 -0.188124658177485 0.00314321575757941 MirTarget -0.0884931207747174 2.3277346499882e-06 26080425 Importantly down-regulation of caspase-8 by miR-21 blocks receptor interacting protein-1 cleavage and induces the activation of NF-κB which regulates these miRNAs lung cancer hsa-miR-421 RIPK1 0.941856334694081 6.12167297054077e-08 -0.188124658177485 0.00314321575757941 miRanda;mirMAP -0.0601973698186341 0.000595949277452741 NA NA NA hsa-miR-107 TNF 0.241662461253461 0.0170788899505389 -1.0038697460391 4.57018472897375e-05 miRanda -0.319449999519582 0.00803039535673001 NA NA NA hsa-miR-361-5p TNF 0.233202959858696 0.00961572812255327 -1.0038697460391 4.57018472897375e-05 miRanda -0.383465948256239 0.00478262683574898 NA NA NA hsa-miR-362-3p TNFRSF10A 0.814007335895913 2.00108618836568e-09 -0.423461160560914 0.0211508401486858 miRanda -0.157747292508836 0.0153709961281209 NA NA NA hsa-miR-17-5p TNFRSF10B 0.698861147045461 2.43854106455398e-05 -0.612825437825455 1.81500500305993e-08 miRNAWalker2_validate -0.118682318607652 0.000225544481104091 NA NA NA hsa-miR-92a-3p TNFRSF10B 0.212391012518195 0.134292268089997 -0.612825437825455 1.81500500305993e-08 miRNAWalker2_validate -0.0930176895166359 0.0147818500798577 NA NA NA hsa-miR-339-5p TNFRSF10D 0.280589919878422 0.0355660282647215 -0.956031437203694 1.87959873199565e-08 miRanda -0.168123800997569 0.00796780173214136 NA NA NA hsa-miR-340-5p TNFRSF10D -0.00477614531381576 0.968502722773791 -0.956031437203694 1.87959873199565e-08 mirMAP -0.147873899667141 0.0355448852664744 NA NA NA hsa-miR-362-3p TNFRSF10D 0.814007335895913 2.00108618836568e-09 -0.956031437203694 1.87959873199565e-08 miRanda -0.140835847455514 0.0213952593708663 NA NA NA hsa-let-7e-5p TNFRSF1A 0.0350298755544731 0.811068614727804 -0.779358458936897 4.22737006131824e-19 miRNAWalker2_validate -0.119647431964113 7.6612668803136e-05 NA NA NA hsa-miR-221-3p TNFSF10 1.12244756358612 3.48370308238012e-13 -0.719605061671142 5.12756319214624e-05 miRNAWalker2_validate;miRTarBase -0.279691652886283 2.76653565272805e-07 NA NA NA hsa-miR-222-3p TNFSF10 1.08574156066353 1.76407192348131e-11 -0.719605061671142 5.12756319214624e-05 miRNAWalker2_validate;miRTarBase -0.257653965579585 8.3406120984635e-07 NA NA NA hsa-miR-361-5p TNFSF10 0.233202959858696 0.00961572812255327 -0.719605061671142 5.12756319214624e-05 miRanda -0.230085953395336 0.0190700346824103 NA NA NA hsa-miR-98-5p TNFSF10 -0.0487189107419432 0.715911066732548 -0.719605061671142 5.12756319214624e-05 miRNAWalker2_validate -0.189663077777932 0.0038160795260408 NA NA NA hsa-miR-10b-5p TP53 2.86931593037303 6.97409423207806e-23 -0.163823087975333 0.268013799235932 miRNAWalker2_validate;miRTarBase -0.051632715248361 0.027182518355288 NA NA NA hsa-miR-122-5p TP53 -1.23907441373955 4.42181244888642e-06 -0.163823087975333 0.268013799235932 miRNATAP -0.104401376732605 6.76735273123785e-05 23221562;22235305 Loss of miR-122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G1-modulated P53 activity.;Surprisingly miR-122 overexpression decreased the sensitivity to the chemotherapy-induced apoptosis via a signaling circuit involving the activation of Akt and inhibition of p53 ; liver cancer;lymphoma hsa-miR-25-3p TP53 0.633062563556379 3.68686354834328e-10 -0.163823087975333 0.268013799235932 miRNAWalker2_validate -0.198477612132015 0.00480268903724675 22431589 The results define miR-25 and -32 as positive regulators of p53 underscoring their role in tumorigenesis in glioblastoma tumorigenesis glioblastoma hsa-miR-491-5p TP53 -0.369122930844418 0.0154047757048929 -0.163823087975333 0.268013799235932 MirTarget;miRanda -0.0985042615437481 0.0393892808171195 23519249 Targeted site prediction indicated that both Bcl-XL and TP53 contain miR-491-5p recognizing sites in their 3' UTRs; Overexpression of miR-491-5p in the pancreatic cancer cell line SW1990 effectively inhibited both endogenous Bcl-XL and TP53 gene expressions pancreatic cancer hsa-miR-320a TRADD 0.325285936317332 0.0221415065838824 0.267724124720407 0.0111863412981626 miRanda -0.174207497115951 1.21612763364167e-06 NA NA NA hsa-miR-320b TRADD 0.0919652022571331 0.607981643616945 0.267724124720407 0.0111863412981626 miRanda -0.0926173502315304 0.00133229857669278 NA NA NA hsa-miR-214-5p TRAF2 -1.91497809567701 3.92955595018147e-12 1.09924183270994 1.20042007323204e-23 MirTarget -0.0789880968673896 8.44547488145796e-05 NA NA NA hsa-miR-106b-5p XIAP 0.648901865047099 8.24870862047885e-09 -0.15308594423064 0.0753030128680062 miRNATAP -0.125473079083479 0.000612516742455432 NA NA NA hsa-miR-140-3p XIAP 0.546012239205329 4.84578261098777e-11 -0.15308594423064 0.0753030128680062 mirMAP -0.139172884619669 0.0053077521694682 NA NA NA hsa-miR-155-5p XIAP 0.0108524225071784 0.95651331033505 -0.15308594423064 0.0753030128680062 MirTarget -0.0523429607668936 0.012897427370423 26779627 Bioinformatic predictions the dual-luciferase reporter assay and western blot analysis were used to detect how miR-155 regulates X-linked inhibitor of apoptosis protein XIAP; Furthermore the results from the luciferase assays and western blot analysis identified XIAP as the direct target of miR-155; In addition introducing XIAP cDNA without a three prime untranslated region 3'-UTR rescued the miR-155 promotion of apoptosis; These results indicate that miR-155 mediates cisplatin-induced apoptosis by targeting XIAP in ovarian cancer cells and that miR-155 could be a potential therapeutic target to increase the efficiency of ovarian cancer interventions ovarian cancer hsa-miR-16-1-3p XIAP 0.392360028038559 0.00112481918108198 -0.15308594423064 0.0753030128680062 mirMAP -0.104804633144744 0.00253046536387569 NA NA NA hsa-miR-17-5p XIAP 0.698861147045461 2.43854106455398e-05 -0.15308594423064 0.0753030128680062 miRNAWalker2_validate;TargetScan -0.160523036445281 6.000729723811e-11 NA NA NA hsa-miR-181a-5p XIAP 0.250113435902954 0.0551933249319293 -0.15308594423064 0.0753030128680062 miRNAWalker2_validate;miRTarBase;mirMAP -0.155528144427296 1.04965693208633e-06 NA NA NA hsa-miR-181b-5p XIAP 0.488256489401108 0.00105321129419701 -0.15308594423064 0.0753030128680062 miRNAWalker2_validate;miRTarBase;mirMAP -0.110373062475686 7.3789440913243e-05 NA NA NA hsa-miR-181c-5p XIAP -0.00639394152050299 0.969127212255928 -0.15308594423064 0.0753030128680062 mirMAP -0.0836637011878322 0.000955375459341138 NA NA NA hsa-miR-19a-3p XIAP 1.01712596153672 2.57753201450625e-07 -0.15308594423064 0.0753030128680062 mirMAP -0.0790876222980443 0.000141887432379118 NA NA NA hsa-miR-19b-1-5p XIAP -0.277804782598538 0.0783067794722916 -0.15308594423064 0.0753030128680062 MirTarget -0.148772325807858 1.26791111877443e-08 NA NA NA hsa-miR-19b-3p XIAP 0.601279551368824 0.00016685097085251 -0.15308594423064 0.0753030128680062 mirMAP -0.102901223661673 7.13974360361232e-05 NA NA NA hsa-miR-20a-5p XIAP 0.854326758727003 5.04256669663285e-07 -0.15308594423064 0.0753030128680062 miRNATAP -0.159439128688726 1.8964942127771e-11 NA NA NA hsa-miR-335-3p XIAP -0.275199247483111 0.106629165248783 -0.15308594423064 0.0753030128680062 mirMAP -0.0576939747338537 0.0188455960484341 NA NA NA hsa-miR-589-3p XIAP 1.16846704028095 5.88525574424201e-11 -0.15308594423064 0.0753030128680062 MirTarget -0.0913649771127463 8.6991519961848e-05 NA NA NA hsa-miR-92a-3p XIAP 0.212391012518195 0.134292268089997 -0.15308594423064 0.0753030128680062 mirMAP -0.139311624854438 2.00037414590705e-06 NA NA NA