miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-17-5p	EGFR	0.698861147045461	2.43854106455398e-05	-1.01672920195188	6.69873186671412e-07	TargetScan	-0.161590563481239	0.00764134099999989		NA	NA	NA
hsa-miR-17-5p	EGLN1	0.698861147045461	2.43854106455398e-05	0.0756107370151957	0.405502512247036	TargetScan	-0.102696431475396	9.47932370331605e-05		NA	NA	NA
hsa-miR-17-5p	HIF1A	0.698861147045461	2.43854106455398e-05	-0.366176828296648	0.0111002186054683	TargetScan	-0.207486649592262	6.73419034465465e-07		NA	NA	NA
hsa-miR-17-5p	JAK1	0.698861147045461	2.43854106455398e-05	-0.491502741052473	2.21647945606145e-08	TargetScan	-0.268052325740918	3.25515675433912e-28		NA	NA	NA
hsa-miR-17-5p	PIK3R1	0.698861147045461	2.43854106455398e-05	-0.891953424131491	1.38465728969785e-08	TargetScan	-0.213954808771155	3.8587060059728e-06		NA	NA	NA
hsa-miR-17-5p	ROCK2	0.698861147045461	2.43854106455398e-05	-0.343723141838983	0.0978147147700846	TargetScan	-0.230848684676223	0.000132737616833034		NA	NA	NA
hsa-miR-17-5p	TGFBR2	0.698861147045461	2.43854106455398e-05	-0.522706741081292	3.47206054315007e-05	TargetScan	-0.203186001893041	2.94531720390227e-08	25011053;27120811	We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer	;	kidney renal cell cancer;gastric cancer
hsa-miR-501-3p	TGFBR2	0.999540908940094	2.77358485581974e-11	-0.522706741081292	3.47206054315007e-05	TargetScan	-0.116887889145825	0.0037841236086272		NA	NA	NA