miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p CSNK2A1 -0.0304750000000005 0.2544201287335 0.290677885621728 0.00160379724667918 miRNAWalker2_validate;TargetScan -0.70017724266611 0.00552826352220561 hsa-let-7b-5p CSNK2A1 -0.118293750000001 0.000772100831422107 0.290677885621728 0.00160379724667918 miRNAWalker2_validate -0.895964742584629 1.1763281417239e-06 hsa-let-7b-5p EP300 -0.118293750000001 0.000772100831422107 0.106443973458177 0.0571948587983776 miRNAWalker2_validate -0.355625601670104 0.00158794954552633 hsa-let-7c-5p CSNK2A1 -0.129896875000002 0.000858548240310724 0.290677885621728 0.00160379724667918 miRNAWalker2_validate -0.814246134133967 9.55407322486361e-07 hsa-let-7e-5p PPP2R1A -0.058575 0.0129021331137325 0.188887135965384 0.000948166169007954 miRNAWalker2_validate -0.694658430015838 7.15209112787486e-05 hsa-miR-101-3p FZD6 -0.128581250000001 3.94323443134545e-05 0.197084128682963 0.170965211951985 miRNAWalker2_validate;MirTarget -1.37363603163473 1.94774169844361e-05 hsa-miR-101-3p RAC1 -0.128581250000001 3.94323443134545e-05 0.120957872181554 0.000358597454614627 miRNAWalker2_validate;MirTarget -0.624210563286132 4.12085526393242e-19 hsa-miR-106b-5p CCND1 0.171446874999999 6.25884640153194e-09 -0.489663700767601 0.00116327564880174 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -1.84430422355467 1.30377841273609e-07 23087084 Furthermore miR-106b upregulation in hepatoma cells modulated entry into the G1/S transitional phase by upregulating cyclin D1 and downregulating APC liver cancer hsa-miR-106b-5p CCND2 0.171446874999999 6.25884640153194e-09 -0.0166722150535952 0.799625753551218 miRNAWalker2_validate;miRTarBase;miRNATAP -0.44669006050993 0.00358841140312301 hsa-miR-10a-5p BTRC -0.290757291666668 1.5263463717526e-09 0.115058906471312 0.0399921555489253 miRNAWalker2_validate;miRTarBase;miRNATAP -0.21292387803745 0.00767194381997323 hsa-miR-10a-5p CSNK2A1 -0.290757291666668 1.5263463717526e-09 0.290677885621728 0.00160379724667918 miRNAWalker2_validate -0.754865672804526 3.91044285930673e-09 hsa-miR-10a-5p MAP3K7 -0.290757291666668 1.5263463717526e-09 0.197672808642468 0.0112927777039728 miRNAWalker2_validate;miRTarBase;MirTarget -0.513983712719477 2.83193855781538e-06 hsa-miR-10b-5p CSNK2A1 -0.027772916666667 0.440518724214005 0.290677885621728 0.00160379724667918 miRNAWalker2_validate -0.44619754908068 0.0169792170712831 hsa-miR-122-5p RAC1 -0.135438541666669 0.00123475246427407 0.120957872181554 0.000358597454614627 miRNAWalker2_validate;miRTarBase -0.491462022277228 1.87376294921914e-21 hsa-miR-122-5p RHOA -0.135438541666669 0.00123475246427407 0.0900101512527449 3.597321051434e-05 miRNAWalker2_validate;miRTarBase -0.283518568694483 1.53009899319842e-17 hsa-miR-122-5p TBL1XR1 -0.135438541666669 0.00123475246427407 0.190962309927984 0.0376557917240184 miRNAWalker2_validate -0.480297382881844 0.00205301378632776 hsa-miR-125b-5p FRAT2 -0.187647916666668 1.01964050843717e-05 0.0314279064539722 0.708449567334936 miRNAWalker2_validate;miRNATAP -0.491959301600434 0.000345173339261034 hsa-miR-126-5p MMP7 0.00174583333333045 0.93995162076006 -1.39655921036109 2.78115729488154e-05 miRNAWalker2_validate -3.80640587063167 0.00035467109297261 hsa-miR-146a-5p ROCK1 -0.148920833333335 0.000192527035623475 -0.0369704386536434 0.563078873222201 miRNAWalker2_validate;miRTarBase -0.243374686702727 0.0315612503202359 hsa-miR-146a-5p SMAD4 -0.148920833333335 0.000192527035623475 -0.0193483612021588 0.537991502197394 miRNAWalker2_validate;miRTarBase -0.163818891085071 0.00260577073422743 hsa-miR-149-5p EP300 -0.0142947916666665 0.594117902122907 0.106443973458177 0.0571948587983776 miRNAWalker2_validate -0.326939247374432 0.0311888753347164 hsa-miR-155-5p SMAD4 0.0446697916666664 0.147941447721798 -0.0193483612021588 0.537991502197394 miRNAWalker2_validate -0.26670618510713 0.000184037228486906 hsa-miR-15b-5p CCND1 0.169857291666666 1.47790035184518e-07 -0.489663700767601 0.00116327564880174 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -1.99414313067549 2.82270779497389e-10 hsa-miR-16-5p TP53 0.0473343749999984 0.0231299407954158 -0.0118226990596053 0.882041063036832 miRNAWalker2_validate;miRTarBase -0.645224879671673 0.0203432758403971 hsa-miR-17-5p CCND1 0.0594531249999994 0.0577784446787179 -0.489663700767601 0.00116327564880174 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -1.30533547682115 0.000175742733492674 18695042 Mammary epithelial cell-targeted cyclin D1 expression induced miR-17-5p and miR-20a expression in vivo and cyclin D1 bound the miR-17/20 cluster promoter regulatory region breast cancer hsa-miR-17-5p CCND2 0.0594531249999994 0.0577784446787179 -0.0166722150535952 0.799625753551218 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.487380360889057 0.0011240273033224 hsa-miR-17-5p PRICKLE1 0.0594531249999994 0.0577784446787179 -0.857244431292353 8.05438071206138e-08 miRNAWalker2_validate -2.02821763827165 4.11127353544415e-08 hsa-miR-17-5p SMAD3 0.0594531249999994 0.0577784446787179 0.252092893656572 0.00235787885298325 miRNAWalker2_validate -0.461318380305278 0.016658796695997 hsa-miR-181a-5p NLK -0.0178312500000008 0.504202611435176 0.17841787778347 0.00756701122609011 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.436204660435418 0.017087543541814 hsa-miR-181a-5p WNT3A -0.0178312500000008 0.504202611435176 -0.0436278843468472 0.272309934158955 miRNAWalker2_validate -0.377925691398296 0.000366682000455939 hsa-miR-183-5p CCND1 0.20613125 6.32481790369784e-05 -0.489663700767601 0.00116327564880174 miRNAWalker2_validate -1.30975614940592 4.99863421431417e-11 hsa-miR-183-5p PPP3R1 0.20613125 6.32481790369784e-05 0.0189274812228692 0.752755399526254 miRNAWalker2_validate -0.178685876522456 0.0292307321546831 hsa-miR-184 NFATC2 0.211478125000001 2.26890637509929e-05 -0.211033921703619 0.0515244993059601 miRNAWalker2_validate -0.624514335496726 3.60183708877511e-05 hsa-miR-18a-5p DAAM2 0.195905208333333 7.199331158466e-05 -0.180255861829957 0.0353055854211658 miRNAWalker2_validate -0.794871281817386 9.46576259569953e-12 hsa-miR-192-5p FZD1 0.0112031249999982 0.726219431607783 -0.709587354482393 8.54998654653992e-08 miRNAWalker2_validate -1.67415478897541 2.69793800691247e-08 hsa-miR-192-5p FZD7 0.0112031249999982 0.726219431607783 -0.288843854014127 0.0509167632008534 miRNAWalker2_validate -2.06142581835785 1.4341191489606e-10 hsa-miR-192-5p PRICKLE1 0.0112031249999982 0.726219431607783 -0.857244431292353 8.05438071206138e-08 miRNAWalker2_validate -1.60956158075972 1.27646386799896e-05 hsa-miR-192-5p TCF7 0.0112031249999982 0.726219431607783 0.154560177240034 0.211770647214088 miRNAWalker2_validate;MirTarget -0.656014627446123 0.0194290773713888 hsa-miR-194-5p EP300 0.0261989583333311 0.382675312355506 0.106443973458177 0.0571948587983776 miRNAWalker2_validate -0.413601996502302 0.00207453325098212 hsa-miR-194-5p RAC1 0.0261989583333311 0.382675312355506 0.120957872181554 0.000358597454614627 miRNAWalker2_validate;miRTarBase;miRNATAP -0.343533080655675 1.95937669897666e-05 hsa-miR-196a-5p CCND2 0.0730552083333349 0.0112355029700135 -0.0166722150535952 0.799625753551218 miRNAWalker2_validate -0.475453115185131 0.0035015990858498 hsa-miR-199a-3p MAPK9 -0.473138541666669 2.11211326609588e-10 0.11555201208399 0.0380112767490297 miRNAWalker2_validate -0.187981355008385 0.000197235414362935 hsa-miR-19a-3p CCND1 0.0212885416666653 0.477294105669598 -0.489663700767601 0.00116327564880174 miRNAWalker2_validate;miRTarBase;miRNATAP -0.970584737350225 0.00857210561170069 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-3p CCND2 -0.0232406250000019 0.402772271458001 -0.0166722150535952 0.799625753551218 miRNAWalker2_validate;MirTarget;miRNATAP -0.392250783316843 0.0218651308328599 hsa-miR-19b-3p DAAM2 -0.0232406250000019 0.402772271458001 -0.180255861829957 0.0353055854211658 miRNAWalker2_validate -0.463133827636491 0.0396400568029918 hsa-miR-19b-3p PRKACB -0.0232406250000019 0.402772271458001 -0.138667096100081 0.140617869700975 miRNAWalker2_validate;MirTarget;miRNATAP -0.682446190877728 0.00546188583349049 hsa-miR-200a-3p TCF7L1 -0.478053125 5.4010344994489e-09 0.0338709240316986 0.578190497535283 miRNAWalker2_validate -0.104049880156354 0.0414154817579334 hsa-miR-200b-3p TCF7L1 -0.525884375 1.04581265194109e-09 0.0338709240316986 0.578190497535283 miRNAWalker2_validate -0.0974312740693898 0.0437427396645102 hsa-miR-206 CCND2 0.0323270833333327 0.132508035975732 -0.0166722150535952 0.799625753551218 miRNAWalker2_validate;PITA;miRNATAP -0.48812657845059 0.0284152000310111 23348698 Further studies demonstrated that miR-206 could suppress GC cells proliferation at least partially through targeting the cyclinD2 CCND2 stomach cancer hsa-miR-20a-5p CCND1 -0.0185229166666687 0.563457138702111 -0.489663700767601 0.00116327564880174 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.893658057160789 0.0095164814743096 hsa-miR-20a-5p CCND2 -0.0185229166666687 0.563457138702111 -0.0166722150535952 0.799625753551218 miRNAWalker2_validate;miRTarBase;miRNATAP -0.437670931863565 0.00293129958495448 hsa-miR-21-5p DAAM1 0.231863541666666 0.000179777588577221 -0.09736079888477 0.257360845225757 miRNAWalker2_validate -0.414458561070938 1.72628283467075e-05 hsa-miR-21-5p PRICKLE2 0.231863541666666 0.000179777588577221 -0.710410295531476 1.70850958175018e-05 miRNAWalker2_validate;MirTarget -0.796104386638856 2.83085160985424e-05 hsa-miR-210-3p APC 0.0719364583333333 0.155976099453465 0.0471771018660387 0.429776421832463 miRNAWalker2_validate -0.182578691387627 0.0305213046052025 hsa-miR-214-3p CTNNB1 -0.3224875 1.46111391717269e-10 0.212559188026568 0.0205459028691703 miRNAWalker2_validate;miRTarBase;MirTarget -0.291329254061143 0.0201234985238529 22962603;22962603 The enhancer of zeste homologue 2 EZH2 and β-catenin CTNNB1 was identified as two potential direct downstream targets of miR-214 through bioinformatics analysis and experimentally validated the miRNA-target interactions with a dual-firefly luciferase reporter assay;Furthermore the silencing of miR-214 or overexpression of EZH2 increased EpCAM+ stem-like cells through the activation of CTNNB1 ; liver cancer;liver cancer hsa-miR-215-5p FZD1 0.0409281249999989 0.214210582881428 -0.709587354482393 8.54998654653992e-08 miRNAWalker2_validate -1.71530163440808 3.38462382517478e-09 hsa-miR-215-5p FZD7 0.0409281249999989 0.214210582881428 -0.288843854014127 0.0509167632008534 miRNAWalker2_validate -2.02083834018026 8.0882601323279e-11 hsa-miR-215-5p PRICKLE1 0.0409281249999989 0.214210582881428 -0.857244431292353 8.05438071206138e-08 miRNAWalker2_validate -1.60747243082806 6.57180698867335e-06 hsa-miR-215-5p TCF7 0.0409281249999989 0.214210582881428 0.154560177240034 0.211770647214088 miRNAWalker2_validate;MirTarget -0.61774644679244 0.0231300452714887 hsa-miR-22-3p CSNK2A1 -0.076525 0.0267118796232183 0.290677885621728 0.00160379724667918 miRNAWalker2_validate -1.00594153907805 9.06581770451938e-08 hsa-miR-22-3p FRAT2 -0.076525 0.0267118796232183 0.0314279064539722 0.708449567334936 miRNAWalker2_validate;MirTarget;miRNATAP -0.734786644692507 1.87382961212205e-05 hsa-miR-221-3p LRP6 0.194085416666666 3.35284955391749e-06 -0.149405434713309 0.015290121892894 miRNAWalker2_validate -0.512174285301849 4.11675476383076e-07 hsa-miR-23b-3p EP300 0.00990312499999879 0.577638557352371 0.106443973458177 0.0571948587983776 miRNAWalker2_validate -0.477845509284824 0.0404071422446096 hsa-miR-24-3p FZD5 -0.00989687500000125 0.593028609143294 0.156615075177879 0.0518533853849842 miRNAWalker2_validate;miRNATAP -1.08414085177376 0.000691825689194414 hsa-miR-26a-5p CTBP1 -0.0802614583333372 6.57714639384254e-05 0.122510686475399 0.000376060446124626 miRNAWalker2_validate -0.414771140317075 0.000698523984364585 hsa-miR-26a-5p GSK3B -0.0802614583333372 6.57714639384254e-05 0.103984137985218 0.0904143607181575 miRNAWalker2_validate;miRNATAP -0.50664403004665 0.0210920642393015 hsa-miR-26b-5p EP300 -0.0469791666666701 0.0492766500438207 0.106443973458177 0.0571948587983776 miRNAWalker2_validate;miRNATAP -0.523189400525082 0.0019701530572461 hsa-miR-26b-5p RUVBL1 -0.0469791666666701 0.0492766500438207 0.32006751436692 6.29695771541672e-06 miRNAWalker2_validate -1.10006572555509 2.97132327085993e-07 hsa-miR-26b-5p SFRP4 -0.0469791666666701 0.0492766500438207 0.723042010172955 0.0177187855512114 miRNAWalker2_validate -5.00747664120475 3.06050036830568e-08 hsa-miR-26b-5p VANGL1 -0.0469791666666701 0.0492766500438207 0.114511596030802 0.21590508129194 miRNAWalker2_validate;mirMAP -0.640160256283435 0.0229815583730232 hsa-miR-26b-5p VANGL2 -0.0469791666666701 0.0492766500438207 -0.356510038890634 0.113213829021286 miRNAWalker2_validate;MirTarget -2.80091236008922 3.46021978968899e-05 hsa-miR-27b-3p CCND3 -0.0034427083333346 0.862641943637602 -0.193453444123804 0.0107139093322308 miRNAWalker2_validate -0.683363280788184 0.0153080568776036 hsa-miR-29a-3p DKK1 -0.0221583333333339 0.423651769453959 1.10210291263388 0.000275551601099095 miRNAWalker2_validate;miRTarBase -2.19131392141445 0.00660890029786309 hsa-miR-301a-3p CCND2 0.3210625 1.40398117330319e-08 -0.0166722150535952 0.799625753551218 miRNAWalker2_validate -0.206186222694222 0.00970148919551925 hsa-miR-302a-3p CCND1 0.0161916666666673 0.580309964436337 -0.489663700767601 0.00116327564880174 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -1.39236428457898 0.000201715397896266 hsa-miR-302c-3p CCND1 0.0507364583333363 0.0669722395347607 -0.489663700767601 0.00116327564880174 miRNAWalker2_validate;miRTarBase -1.50664195941147 0.000134546815728292 hsa-miR-30a-3p EP300 0.0310927083333314 0.212235313484241 0.106443973458177 0.0571948587983776 miRNAWalker2_validate;MirTarget;miRNATAP -0.622214128430858 0.000113541848974564 hsa-miR-30c-5p CSNK1E -0.0468291666666689 0.0597963082931316 0.278817302483912 0.00101487072640408 miRNAWalker2_validate -1.74140723317955 1.28291841191075e-13 hsa-miR-30c-5p EP300 -0.0468291666666689 0.0597963082931316 0.106443973458177 0.0571948587983776 miRNAWalker2_validate -0.708152733561779 9.7495864038532e-06 hsa-miR-30c-5p PLCB1 -0.0468291666666689 0.0597963082931316 0.803184556911579 2.54367115402579e-06 miRNAWalker2_validate -3.75437213519339 3.39426876125308e-15 hsa-miR-30c-5p RAC1 -0.0468291666666689 0.0597963082931316 0.120957872181554 0.000358597454614627 miRNAWalker2_validate -0.652743814163433 2.86349510794686e-12 hsa-miR-30c-5p TBL1XR1 -0.0468291666666689 0.0597963082931316 0.190962309927984 0.0376557917240184 miRNAWalker2_validate -0.59486593519568 0.0271679821673112 hsa-miR-320a FRAT2 0.0244749999999987 0.226230360993065 0.0314279064539722 0.708449567334936 miRNAWalker2_validate -0.77044849482951 0.0112569799230034 hsa-miR-324-3p CSNK1A1 0.0222333333333327 0.245608749949032 -0.138624470628192 0.0227394315885017 miRNAWalker2_validate -0.477300260822957 0.042089643788721 hsa-miR-324-3p WNT9B 0.0222333333333327 0.245608749949032 -0.317909400606925 0.019808954791012 miRNAWalker2_validate -1.32775183531595 0.011824863109673 hsa-miR-335-5p FZD10 0.0194229166666655 0.799340877520213 0.213117453805136 0.0336419349181034 miRNAWalker2_validate -0.192360345551921 0.0428547487943896 hsa-miR-335-5p FZD8 0.0194229166666655 0.799340877520213 -0.263289416025741 0.048690560726977 miRNAWalker2_validate -0.335897764891752 0.00766488167940902 hsa-miR-335-5p PRICKLE2 0.0194229166666655 0.799340877520213 -0.710410295531476 1.70850958175018e-05 miRNAWalker2_validate -0.325826201008196 0.0410340931526179 hsa-miR-335-5p VANGL2 0.0194229166666655 0.799340877520213 -0.356510038890634 0.113213829021286 miRNAWalker2_validate -0.54235052857782 0.0106033150951479 hsa-miR-33a-5p MAPK8 0.159034374999999 2.69680061078e-07 -0.171765768887781 0.0118048295600565 miRNAWalker2_validate -0.906774834777096 1.17457696034423e-09 hsa-miR-34b-5p MYC 0.106034375000001 0.00022824345015252 -0.477164636319847 0.0167562282914519 miRNAWalker2_validate;miRTarBase -2.38180769840275 9.83674705130892e-07 hsa-miR-34c-5p MYC 0.200814583333336 5.32673441685204e-05 -0.477164636319847 0.0167562282914519 miRNAWalker2_validate;miRTarBase;miRanda -0.662224416671857 0.0203216033552727 22370637 We demonstrate that Bmf Bcl-2-modifying factor is a target of miR-34c-5p and that its silencing together with that of c-myc a known target of miR-34c-5p contributes to resistance to apoptosis induced by paclitaxel through p53 downregulation drug resistance; lung cancer hsa-miR-375 PRKCA -0.553344791666666 8.52426333986314e-09 0.185818287677706 0.0154752151667042 miRNAWalker2_validate -0.17945071949969 0.00107899422565883 23497265 The integrated analysis of miRNA and mRNA expression identified 35 known and novel target genes of miR-200c miR-205 and mir-375 including CFL2 LAMC1 TIMP2 ZEB1 CDH11 PRKCA PTPRJ PTPRM LDHB and SEC23A breast cancer hsa-miR-375 RHOA -0.553344791666666 8.52426333986314e-09 0.0900101512527449 3.597321051434e-05 miRNAWalker2_validate -0.0751787859991243 4.48314872479713e-07 hsa-miR-429 TCF7L1 -0.0799427083333338 0.00239378361551957 0.0338709240316986 0.578190497535283 miRNAWalker2_validate -0.545038120208939 0.000918993744931929 hsa-miR-7-5p CAMK2D 0.112319791666666 6.89435265439898e-05 -0.200760394239715 0.00604513510738709 miRNAWalker2_validate -0.516005328358472 0.00530331531198911 hsa-miR-7-5p LRP6 0.112319791666666 6.89435265439898e-05 -0.149405434713309 0.015290121892894 miRNAWalker2_validate;miRNATAP -0.613636763867305 6.51947311575657e-05 hsa-miR-9-5p CCND1 0.206358333333334 0.00474844163137852 -0.489663700767601 0.00116327564880174 miRNAWalker2_validate -0.510060266944109 0.000546908607868954 hsa-miR-9-5p NFATC3 0.206358333333334 0.00474844163137852 -0.197504610403103 0.000313375676516591 miRNAWalker2_validate;MirTarget;miRNATAP -0.162489352927906 0.00247239624526531 hsa-miR-92a-3p GSK3B -0.0250031250000018 0.378880808632843 0.103984137985218 0.0904143607181575 miRNAWalker2_validate -0.506473268399699 0.00113835744245679 hsa-miR-92a-3p PPARD -0.0250031250000018 0.378880808632843 0.118552935962505 0.0143804727683645 miRNAWalker2_validate -0.271896124981603 0.0280587209995606 hsa-miR-92a-3p PRKCA -0.0250031250000018 0.378880808632843 0.185818287677706 0.0154752151667042 miRNAWalker2_validate -0.551839082424296 0.00495081068033053 hsa-miR-93-5p CCND1 0.188120833333332 2.87978994240045e-10 -0.489663700767601 0.00116327564880174 miRNAWalker2_validate;MirTarget;miRNATAP -1.93546134841602 1.37539761137695e-08 25371073 Furthermore miR-93 may downregulate the Wnt/β-catenin pathway which was confirmed by measuring the expression level of the β-catenin axin c-Myc and cyclin-D1 in this pathway colorectal cancer hsa-miR-93-5p JUN 0.188120833333332 2.87978994240045e-10 -0.501788712602393 4.9924247594369e-05 miRNAWalker2_validate -1.05512114602959 0.00025823578074446 hsa-miR-135b-5p APC -0.108287499999999 0.00127396707132353 0.0471771018660387 0.429776421832463 miRTarBase;MirTarget -0.276601429478955 0.0288144548693035 hsa-miR-100-5p FZD5 -0.138515625000001 0.00081394770627749 0.156615075177879 0.0518533853849842 MirTarget;miRNATAP -0.474732016361777 0.00056455265428372 hsa-miR-101-3p NLK -0.128581250000001 3.94323443134545e-05 0.17841787778347 0.00756701122609011 MirTarget;miRNATAP -0.3373550345048 0.0268319717789668 hsa-miR-103a-3p WNT7A 0.111741666666665 2.24432368503744e-06 -0.108413571375356 0.0168746103341194 MirTarget -0.299098142114777 0.0279361435656359 hsa-miR-105-5p PRICKLE2 0.172322916666667 0.00159136123673933 -0.710410295531476 1.70850958175018e-05 MirTarget;miRNATAP -0.762420445046548 0.00048322230302906 hsa-miR-105-5p PRKX 0.172322916666667 0.00159136123673933 0.0295582203370106 0.735259443898609 MirTarget -0.310960204434783 0.00607639626722648 hsa-miR-106a-5p CCND1 0.0520072916666667 0.124210545689816 -0.489663700767601 0.00116327564880174 MirTarget;miRNATAP -1.17066463974754 0.000286379668532775 hsa-miR-10a-5p CAMK2G -0.290757291666668 1.5263463717526e-09 0.203579825180791 0.00105262020237704 MirTarget;miRNATAP -0.555411055136799 8.20903618884671e-11 hsa-miR-10b-5p CAMK2G -0.027772916666667 0.440518724214005 0.203579825180791 0.00105262020237704 MirTarget;miRNATAP -0.339638766477904 0.006838672365728 hsa-miR-124-3p NFATC2 0.0765510416666685 0.0406801811765009 -0.211033921703619 0.0515244993059601 MirTarget;miRNATAP -0.514474458459657 0.0138122660583814 hsa-miR-125a-5p CSNK2A1 -0.127755208333335 0.000138704165746353 0.290677885621728 0.00160379724667918 MirTarget;PITA;miRanda -0.64022828052579 0.00109358161407665 hsa-miR-125b-5p CSNK2A1 -0.187647916666668 1.01964050843717e-05 0.290677885621728 0.00160379724667918 MirTarget;miRNATAP -0.857650638943658 8.06163187846953e-09 hsa-miR-126-5p PRKX 0.00174583333333045 0.93995162076006 0.0295582203370106 0.735259443898609 MirTarget;miRNATAP -0.898320400504223 0.00101321363210952 hsa-miR-126-5p MAP3K7 0.00174583333333045 0.93995162076006 0.197672808642468 0.0112927777039728 MirTarget -0.944011281262889 0.00011279717154809 hsa-miR-128-3p PPP2R1B 0.0802104166666665 0.00179639587493942 -0.0180197149409391 0.78139480749852 MirTarget -0.445203453907186 0.0138398323478393 hsa-miR-128-3p VANGL2 0.0802104166666665 0.00179639587493942 -0.356510038890634 0.113213829021286 MirTarget -2.59373891835954 3.09540797015871e-05 hsa-miR-128-3p PRKX 0.0802104166666665 0.00179639587493942 0.0295582203370106 0.735259443898609 MirTarget -0.540412901445521 0.0270348672600776 hsa-miR-129-5p EP300 -0.00798437499999771 0.794722371016669 0.106443973458177 0.0571948587983776 MirTarget;PITA;miRanda;miRNATAP -0.292986422084828 0.0266771668681812 hsa-miR-130a-3p TBL1XR1 -0.191241666666667 4.92233337068236e-06 0.190962309927984 0.0376557917240184 MirTarget -0.440453133265361 0.00428994807445435 hsa-miR-130b-3p FOSL1 0.187960416666667 4.08884220213037e-05 -0.543265687537282 0.00108910764212718 MirTarget -1.34100035045685 1.03927162273212e-07 hsa-miR-130b-3p DAAM1 0.187960416666667 4.08884220213037e-05 -0.09736079888477 0.257360845225757 MirTarget;miRNATAP -0.543718185161884 2.99164763541603e-05 hsa-miR-136-5p FZD4 -0.0527270833333332 0.32506258632716 0.0472296826427225 0.558273177603475 MirTarget -0.297832477378097 0.00572133118352769 hsa-miR-137 MAP3K7 0.0312114583333318 0.288380289785221 0.197672808642468 0.0112927777039728 MirTarget;miRanda -0.501944874314354 0.00935611061025542 hsa-miR-138-5p DVL2 -0.209624999999998 0.000133819772849317 0.392328080664631 8.7563438221752e-08 MirTarget;miRNATAP -0.265009136140758 0.0065172050538058 hsa-miR-138-5p CAMK2A -0.209624999999998 0.000133819772849317 0.154859457150701 0.0544358635832875 MirTarget -0.270098667847559 0.00921302795515993 hsa-miR-139-5p PRKX -0.0753822916666668 0.00238689962038074 0.0295582203370106 0.735259443898609 MirTarget -0.978425685583719 9.10703118370647e-05 hsa-miR-139-5p MAP3K7 -0.0753822916666668 0.00238689962038074 0.197672808642468 0.0112927777039728 MirTarget -1.25001302210479 1.32849860910519e-08 hsa-miR-139-5p PPP3CB -0.0753822916666668 0.00238689962038074 0.204701290405443 0.00444522807319962 MirTarget;PITA;miRanda -0.651345123867712 0.00185273372292522 hsa-miR-142-3p TBL1X -0.061707291666669 0.145842401503657 0.309411886883789 0.00218320488622219 MirTarget;PITA;miRanda;miRNATAP -0.536482462939566 0.00183586717267009 hsa-miR-143-3p CSNK2A1 -0.0935458333333352 0.00823730512879721 0.290677885621728 0.00160379724667918 MirTarget -0.739459502138602 7.07877266781792e-05 hsa-miR-143-3p MAP3K7 -0.0935458333333352 0.00823730512879721 0.197672808642468 0.0112927777039728 MirTarget;miRNATAP -0.476188568573193 0.00259792119931057 hsa-miR-144-3p TBL1XR1 -0.112929166666666 0.0224448327150592 0.190962309927984 0.0376557917240184 MirTarget -0.348202339551854 0.00894488122504446 hsa-miR-144-3p PRKX -0.112929166666666 0.0224448327150592 0.0295582203370106 0.735259443898609 MirTarget -0.285962460928244 0.0235565837704988 hsa-miR-145-5p SENP2 -0.195591666666668 1.95566035199164e-06 0.153793745225116 0.00900042829073861 MirTarget -0.417557693279652 2.55127813709534e-05 hsa-miR-145-5p SMAD2 -0.195591666666668 1.95566035199164e-06 0.233004999272719 0.0002706418147499 MirTarget -0.390154500021946 0.000366173990029636 hsa-miR-146a-5p RAC1 -0.148920833333335 0.000192527035623475 0.120957872181554 0.000358597454614627 MirTarget -0.188914919179115 0.00158063265017875 hsa-miR-147a CCND1 0.0934770833333343 0.00179214699390234 -0.489663700767601 0.00116327564880174 MirTarget -2.2981558822957 4.08971568031492e-11 hsa-miR-147a NFAT5 0.0934770833333343 0.00179214699390234 -0.117746017099222 0.309971021909308 MirTarget;miRNATAP -0.611451946169764 0.0277958456374122 hsa-miR-148a-3p SMAD2 -0.0141499999999994 0.738059428971636 0.233004999272719 0.0002706418147499 MirTarget;mirMAP -0.597742026341011 2.24222427936135e-08 hsa-miR-148a-3p PRKX -0.0141499999999994 0.738059428971636 0.0295582203370106 0.735259443898609 MirTarget -0.78718383371488 4.74915998792601e-08 hsa-miR-148b-3p PRICKLE2 0.138957291666665 6.22558400405251e-09 -0.710410295531476 1.70850958175018e-05 MirTarget;miRNATAP -2.72945993093603 1.05394773070822e-08 hsa-miR-150-5p DVL3 -0.176727083333334 0.000745566468765205 0.114446993590549 0.000831052646869237 MirTarget -0.279857430745727 2.53680292882204e-10 hsa-miR-150-5p NLK -0.176727083333334 0.000745566468765205 0.17841787778347 0.00756701122609011 MirTarget -0.444853883873523 5.23207911298566e-07 hsa-miR-152-3p PRICKLE2 -0.000978125000000718 0.97674098120955 -0.710410295531476 1.70850958175018e-05 MirTarget -0.99122445137415 0.00650029428716199 hsa-miR-152-3p SMAD2 -0.000978125000000718 0.97674098120955 0.233004999272719 0.0002706418147499 MirTarget -0.62660770398591 4.85592436179116e-06 hsa-miR-152-3p PRKX -0.000978125000000718 0.97674098120955 0.0295582203370106 0.735259443898609 MirTarget -0.61783757178288 0.000950498235003577 hsa-miR-154-5p CAMK2G -0.193282291666667 0.00377873532464293 0.203579825180791 0.00105262020237704 MirTarget;miRNATAP -0.15484988126624 0.0206064463996162 hsa-miR-155-5p TCF7L2 0.0446697916666664 0.147941447721798 -0.12476485755165 0.075666606325994 MirTarget;miRNATAP -0.404264389022701 0.0139826517044401 hsa-miR-15b-5p WNT7A 0.169857291666666 1.47790035184518e-07 -0.108413571375356 0.0168746103341194 MirTarget -0.198364566462103 0.0431849823560681 hsa-miR-15b-5p NFATC3 0.169857291666666 1.47790035184518e-07 -0.197504610403103 0.000313375676516591 MirTarget;miRNATAP -0.567345242607962 1.24342992842937e-06 hsa-miR-16-5p WNT7A 0.0473343749999984 0.0231299407954158 -0.108413571375356 0.0168746103341194 MirTarget -0.498630325819841 0.00154763419311145 hsa-miR-16-5p NFATC3 0.0473343749999984 0.0231299407954158 -0.197504610403103 0.000313375676516591 MirTarget;miRNATAP -0.517687820875356 0.0074360831351557 hsa-miR-17-3p PPP3CA 0.00967708333333311 0.633038751711409 -0.163058424706868 0.00164514523193859 MirTarget -0.45429819072111 0.0161825726260574 hsa-miR-17-5p FZD3 0.0594531249999994 0.0577784446787179 -0.0766252193650088 0.497157021376042 MirTarget;TargetScan;mirMAP;miRNATAP -0.528807268942599 0.0421499643078822 hsa-miR-181a-5p TBL1X -0.0178312500000008 0.504202611435176 0.309411886883789 0.00218320488622219 MirTarget;miRNATAP -0.641544085997424 0.0210836813543982 hsa-miR-181c-5p TBL1X -0.0391416666666661 0.24873704977008 0.309411886883789 0.00218320488622219 MirTarget;miRNATAP -0.540164511453114 0.0128731647843582 hsa-miR-182-5p PRICKLE2 0.137020833333333 0.00166040840475327 -0.710410295531476 1.70850958175018e-05 MirTarget -1.3499152091491 5.55241411026378e-07 hsa-miR-182-5p PRKACB 0.137020833333333 0.00166040840475327 -0.138667096100081 0.140617869700975 MirTarget;miRNATAP -0.311009464817594 0.0438606709271188 hsa-miR-183-5p DAAM1 0.20613125 6.32481790369784e-05 -0.09736079888477 0.257360845225757 MirTarget;miRNATAP -0.492153504762693 2.11593834193324e-05 hsa-miR-183-5p PRKACB 0.20613125 6.32481790369784e-05 -0.138667096100081 0.140617869700975 MirTarget -0.322051460047863 0.012469788254981 hsa-miR-183-5p PPP2R5C 0.20613125 6.32481790369784e-05 -0.150909959174399 0.0114911146917879 MirTarget;miRNATAP -0.267457237096886 0.00102655437918859 hsa-miR-183-5p TCF7L2 0.20613125 6.32481790369784e-05 -0.12476485755165 0.075666606325994 MirTarget;miRNATAP -0.220155364153178 0.0222036739217349 hsa-miR-184 FZD1 0.211478125000001 2.26890637509929e-05 -0.709587354482393 8.54998654653992e-08 MirTarget -1.07253466401392 9.8460927767169e-09 hsa-miR-184 CAMK2B 0.211478125000001 2.26890637509929e-05 -0.845476560565095 1.72449919556697e-07 MirTarget;miRanda -0.608344960478468 0.00992688440635337 hsa-miR-185-5p CCND2 0.114770833333333 3.04516894436275e-07 -0.0166722150535952 0.799625753551218 MirTarget;miRNATAP -0.594075206818316 0.00385185970403877 hsa-miR-185-5p VANGL2 0.114770833333333 3.04516894436275e-07 -0.356510038890634 0.113213829021286 MirTarget -4.25548995176566 4.46740349155549e-10 hsa-miR-185-5p NFATC2 0.114770833333333 3.04516894436275e-07 -0.211033921703619 0.0515244993059601 MirTarget -1.28158974822125 0.000158399166225069 hsa-miR-185-5p NFATC3 0.114770833333333 3.04516894436275e-07 -0.197504610403103 0.000313375676516591 MirTarget;miRNATAP -0.476663783497979 0.00623508168689815 hsa-miR-186-5p PRICKLE2 0.119613541666665 4.08271418900568e-07 -0.710410295531476 1.70850958175018e-05 MirTarget -2.28840117126376 3.89083556527741e-06 hsa-miR-193a-3p BTRC 0.0943291666666665 0.0034681283330623 0.115058906471312 0.0399921555489253 MirTarget;miRanda -0.314916897002434 0.0112006182105736 hsa-miR-194-5p FZD6 0.0261989583333311 0.382675312355506 0.197084128682963 0.170965211951985 MirTarget -1.60855514504958 2.37351684917215e-06 hsa-miR-195-5p TBL1XR1 -0.182735416666667 8.68760983755402e-06 0.190962309927984 0.0376557917240184 MirTarget -0.535218700206898 0.00063485688427772 hsa-miR-195-5p BTRC -0.182735416666667 8.68760983755402e-06 0.115058906471312 0.0399921555489253 MirTarget;miRNATAP -0.404282256992363 1.80852265384963e-05 23544130 Among the candidates we successfully identified CCNE1 CDC25A CCND3 CDK4 and BTRC as direct targets for miR-497 and miR-195 liver cancer hsa-miR-199a-3p FBXW11 -0.473138541666669 2.11211326609588e-10 0.103076252948277 0.0132185858141707 MirTarget;PITA;miRNATAP -0.0851858358827924 0.0251563223212006 hsa-miR-199a-3p NLK -0.473138541666669 2.11211326609588e-10 0.17841787778347 0.00756701122609011 MirTarget;PITA;miRNATAP -0.288108093169524 1.70800129215019e-06 hsa-miR-199a-5p NLK -0.439753125000001 5.11264621396001e-10 0.17841787778347 0.00756701122609011 MirTarget;PITA;miRanda;miRNATAP -0.281881768451124 9.9686358099622e-06 hsa-miR-199a-5p BTRC -0.439753125000001 5.11264621396001e-10 0.115058906471312 0.0399921555489253 MirTarget;miRanda;miRNATAP -0.158587346749265 0.00329237679522062 hsa-miR-199b-5p NLK -0.220826041666666 0.000676554402277228 0.17841787778347 0.00756701122609011 MirTarget;PITA;miRanda;miRNATAP -0.26190228061524 0.000306014271365411 hsa-miR-199b-5p BTRC -0.220826041666666 0.000676554402277228 0.115058906471312 0.0399921555489253 MirTarget;miRanda;miRNATAP -0.159364020416008 0.00896514695036582 hsa-miR-19a-3p CCND2 0.0212885416666653 0.477294105669598 -0.0166722150535952 0.799625753551218 MirTarget;miRNATAP -0.365860014172244 0.020889152314887 hsa-miR-19a-3p PRKACB 0.0212885416666653 0.477294105669598 -0.138667096100081 0.140617869700975 MirTarget;miRNATAP -0.549395828754299 0.0159580257592828 hsa-miR-19a-3p FOSL1 0.0212885416666653 0.477294105669598 -0.543265687537282 0.00108910764212718 MirTarget -1.72180912953575 1.78789527545689e-05 23831570;23831570;23831570 MicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogene;Further transfection of RAW264.7 macrophage cells with the miR-19a-3p mimic decreased the expression of the Fra-1 downstream genes VEGF STAT3 and pSTAT3;Taken together these findings indicate that miR-19a-3p is capable of downregulating the M2 phenotype in M2 macrophages and that the low expression of this miRNA has an important role in the upregulation of Fra-1 expression and induction of M2 macrophage polarization metastasis;progression;;; breast cancer;breast cancer;breast cancer hsa-miR-19a-3p FZD6 0.0212885416666653 0.477294105669598 0.197084128682963 0.170965211951985 MirTarget -0.708447244809961 0.0428600392609864 hsa-miR-19b-3p FOSL1 -0.0232406250000019 0.402772271458001 -0.543265687537282 0.00108910764212718 MirTarget -1.06101571311894 0.0160622442180084 hsa-miR-19b-3p FZD6 -0.0232406250000019 0.402772271458001 0.197084128682963 0.170965211951985 MirTarget -1.34766869926028 0.000307978295766931 hsa-miR-200b-3p RHOA -0.525884375 1.04581265194109e-09 0.0900101512527449 3.597321051434e-05 MirTarget;TargetScan -0.0580939113380336 0.000553810987227434 hsa-miR-200b-3p TBL1XR1 -0.525884375 1.04581265194109e-09 0.190962309927984 0.0376557917240184 MirTarget;TargetScan;mirMAP -0.170898649279544 0.0198146750891451 hsa-miR-200b-3p FBXW11 -0.525884375 1.04581265194109e-09 0.103076252948277 0.0132185858141707 MirTarget;TargetScan -0.130003532202598 6.41622406754749e-05 hsa-miR-203a-3p CUL1 -0.272541666666666 2.72800682847338e-05 0.620515023663135 1.82070009279316e-08 MirTarget -0.511689539521811 2.84754369816908e-05 hsa-miR-204-5p TCF7L1 0.0144822916666668 0.790232989544289 0.0338709240316986 0.578190497535283 MirTarget;miRNATAP -0.288663701140888 0.000276979491303011 hsa-miR-206 SFRP1 0.0323270833333327 0.132508035975732 -0.918311685823821 4.23744371853458e-08 MirTarget;PITA;miRanda;miRNATAP -1.32311331146078 0.025628560119367 hsa-miR-206 FZD7 0.0323270833333327 0.132508035975732 -0.288843854014127 0.0509167632008534 MirTarget;PITA;miRanda;miRNATAP -1.52725863428235 0.0024069863281379 hsa-miR-206 NFATC2 0.0323270833333327 0.132508035975732 -0.211033921703619 0.0515244993059601 MirTarget;miRNATAP -0.740186274639998 0.0459543936867241 hsa-miR-20a-5p FZD3 -0.0185229166666687 0.563457138702111 -0.0766252193650088 0.497157021376042 MirTarget;mirMAP;miRNATAP -0.594462313092441 0.0196775371329628 hsa-miR-212-3p TCF7L1 0.0388781249999999 0.0317156285118969 0.0338709240316986 0.578190497535283 MirTarget;miRNATAP -0.607282398184526 0.0136215174288737 hsa-miR-212-3p DAAM1 0.0388781249999999 0.0317156285118969 -0.09736079888477 0.257360845225757 MirTarget;miRNATAP -0.734285667978859 0.0356633912138025 hsa-miR-214-3p TBL1XR1 -0.3224875 1.46111391717269e-10 0.190962309927984 0.0376557917240184 MirTarget -0.436931118012541 0.000434120550878695 hsa-miR-214-3p CTBP1 -0.3224875 1.46111391717269e-10 0.122510686475399 0.000376060446124626 MirTarget -0.0948414907015459 0.0430853826323496 hsa-miR-214-3p CAMK2A -0.3224875 1.46111391717269e-10 0.154859457150701 0.0544358635832875 MirTarget;mirMAP -0.240257053839093 0.0285879041004228 hsa-miR-214-3p BTRC -0.3224875 1.46111391717269e-10 0.115058906471312 0.0399921555489253 MirTarget -0.213524779235706 0.00487189455136611 hsa-miR-217 NFAT5 0.0874812500000005 0.117292906648424 -0.117746017099222 0.309971021909308 MirTarget;miRanda -0.431527815381162 0.00366518952984429 hsa-miR-217 PPP2R5E 0.0874812500000005 0.117292906648424 -0.0680113241094285 0.488239722399933 MirTarget -0.36652822984852 0.00348773335181237 hsa-miR-217 TCF7L2 0.0874812500000005 0.117292906648424 -0.12476485755165 0.075666606325994 MirTarget;miRanda;miRNATAP -0.377994939694291 2.08571604860691e-05 hsa-miR-218-5p PPP2R5A -0.138427083333333 0.00268394855424833 0.0231605922470068 0.523579611581263 MirTarget;miRNATAP -0.163719320663484 0.00293869354667924 hsa-miR-22-3p EP300 -0.076525 0.0267118796232183 0.106443973458177 0.0571948587983776 MirTarget;miRNATAP -0.816675545124324 6.96262843695264e-14 hsa-miR-221-3p NFATC3 0.194085416666666 3.35284955391749e-06 -0.197504610403103 0.000313375676516591 MirTarget;miRNATAP -0.416342962312547 5.07215166394607e-06 hsa-miR-222-3p NFATC3 0.154138541666667 3.31108124679705e-05 -0.197504610403103 0.000313375676516591 MirTarget;miRNATAP -0.473587965935862 4.5794720221447e-06 hsa-miR-24-1-5p TCF7L2 0.0185166666666668 0.391075093967781 -0.12476485755165 0.075666606325994 MirTarget -0.772217458562743 0.00111051873325025 hsa-miR-24-3p VANGL2 -0.00989687500000125 0.593028609143294 -0.356510038890634 0.113213829021286 MirTarget -4.87775416722059 2.16102563294376e-08 hsa-miR-24-3p NFATC2 -0.00989687500000125 0.593028609143294 -0.211033921703619 0.0515244993059601 MirTarget -1.91262397158234 7.04575802568611e-06 hsa-miR-27a-3p SMAD4 -0.00334791666666856 0.862458239652667 -0.0193483612021588 0.537991502197394 MirTarget -0.281934638383142 0.0163131689071469 hsa-miR-27b-3p PRKX -0.0034427083333346 0.862641943637602 0.0295582203370106 0.735259443898609 MirTarget;miRNATAP -0.951875372491671 0.00305103882768162 hsa-miR-296-5p PPP2R5B -0.051979166666666 0.317929286008195 0.140697784708815 0.016178286052138 MirTarget;miRNATAP -0.279460076108612 0.000504863592273604 hsa-miR-29a-3p PRICKLE2 -0.0221583333333339 0.423651769453959 -0.710410295531476 1.70850958175018e-05 MirTarget;miRNATAP -1.44417220481061 0.00105051232742651 hsa-miR-29b-3p PRICKLE2 0.0261354166666654 0.47093801212574 -0.710410295531476 1.70850958175018e-05 MirTarget;miRNATAP -1.43176947413163 1.56981162897299e-05 hsa-miR-29c-3p PRICKLE2 -0.119800000000001 0.0103503840465436 -0.710410295531476 1.70850958175018e-05 MirTarget;miRNATAP -0.552079081037502 0.0331593345352846 hsa-miR-301a-3p FOSL1 0.3210625 1.40398117330319e-08 -0.543265687537282 0.00108910764212718 MirTarget -1.10812252105068 2.62584002459148e-08 hsa-miR-301a-3p DAAM1 0.3210625 1.40398117330319e-08 -0.09736079888477 0.257360845225757 MirTarget;miRNATAP -0.369377311034725 0.000377738348253236 hsa-miR-302b-3p PPP3R1 -0.0521843749999984 0.249006520516215 0.0189274812228692 0.752755399526254 MirTarget -0.213694547165232 0.0246919165573853 hsa-miR-302c-3p FZD3 0.0507364583333363 0.0669722395347607 -0.0766252193650088 0.497157021376042 MirTarget -0.935852068182684 0.00140258796797539 hsa-miR-302c-5p SFRP1 0.0869791666666674 0.0136966249723328 -0.918311685823821 4.23744371853458e-08 MirTarget -2.04982988094074 1.72071254038374e-09 hsa-miR-302c-5p FZD4 0.0869791666666674 0.0136966249723328 0.0472296826427225 0.558273177603475 MirTarget -0.744635930554975 3.42575811512387e-06 hsa-miR-302c-5p WNT2 0.0869791666666674 0.0136966249723328 -0.908591483294797 1.27750228597462e-10 MirTarget -1.21005041934597 5.08774445929239e-05 hsa-miR-302d-3p FZD3 0.0472260416666677 0.112646882151868 -0.0766252193650088 0.497157021376042 MirTarget -0.65410727996298 0.0169907901257991 hsa-miR-30a-3p CACYBP 0.0310927083333314 0.212235313484241 0.422038682623345 1.39499697971974e-06 MirTarget -0.578344480294047 0.0277849888609032 hsa-miR-30a-3p MAP3K7 0.0310927083333314 0.212235313484241 0.197672808642468 0.0112927777039728 MirTarget -0.892791102790349 7.8458278396397e-05 hsa-miR-30b-5p NFATC2 0.0675958333333311 0.0250792126411936 -0.211033921703619 0.0515244993059601 MirTarget;mirMAP -1.17909831128378 3.61226468292934e-06 hsa-miR-30c-5p FZD3 -0.0468291666666689 0.0597963082931316 -0.0766252193650088 0.497157021376042 MirTarget;miRNATAP -0.65032858614227 0.0486390132704395 hsa-miR-30c-5p NFATC2 -0.0468291666666689 0.0597963082931316 -0.211033921703619 0.0515244993059601 MirTarget;mirMAP -0.958091142552675 0.00242110562353926 hsa-miR-30d-5p NFATC2 0.0889593749999984 0.00165769192018322 -0.211033921703619 0.0515244993059601 MirTarget;mirMAP -0.792156919323448 0.00395660792919959 hsa-miR-30d-5p NFATC3 0.0889593749999984 0.00165769192018322 -0.197504610403103 0.000313375676516591 MirTarget;miRNATAP -0.481862015977498 0.000541511071148164 hsa-miR-30e-3p CACYBP -0.0753822916666668 0.0158956125513102 0.422038682623345 1.39499697971974e-06 MirTarget -1.26485712866325 1.59180165976284e-10 hsa-miR-30e-3p EP300 -0.0753822916666668 0.0158956125513102 0.106443973458177 0.0571948587983776 MirTarget -0.568388087103361 6.65865526131762e-06 hsa-miR-30e-3p MAP3K7 -0.0753822916666668 0.0158956125513102 0.197672808642468 0.0112927777039728 MirTarget -1.00321205388549 8.47851321421176e-09 hsa-miR-30e-3p CAMK2G -0.0753822916666668 0.0158956125513102 0.203579825180791 0.00105262020237704 MirTarget -0.516808233025863 0.000299272125282558 hsa-miR-30e-5p NFATC2 -0.0271500000000011 0.286699748910542 -0.211033921703619 0.0515244993059601 MirTarget -1.27230597501712 3.1925163662273e-05 hsa-miR-31-5p NFATC3 -0.0442958333333314 0.29411095127741 -0.197504610403103 0.000313375676516591 MirTarget -0.210664619829116 0.0259827038648719 hsa-miR-323a-3p NLK -0.0647520833333322 0.423729214327369 0.17841787778347 0.00756701122609011 MirTarget;miRNATAP -0.129336491576173 0.030153564202194 hsa-miR-326 WNT7B -0.0456083333333334 0.108670355811767 -0.0233939293061791 0.550966964308638 MirTarget;miRanda -0.220418787815623 0.0255819723533056 hsa-miR-326 TBL1XR1 -0.0456083333333334 0.108670355811767 0.190962309927984 0.0376557917240184 MirTarget;PITA;miRanda -0.53764503088914 0.0221186744657182 hsa-miR-328-3p TCF7L2 -0.0288135416666668 0.280297210540175 -0.12476485755165 0.075666606325994 MirTarget -0.378566714607421 0.048329098385592 hsa-miR-330-3p PRICKLE2 0.0475489583333344 0.000859543426581515 -0.710410295531476 1.70850958175018e-05 MirTarget -4.17460724742828 1.22387727594229e-06 hsa-miR-330-3p CCND3 0.0475489583333344 0.000859543426581515 -0.193453444123804 0.0107139093322308 MirTarget;miRNATAP -0.969052503112145 0.0145572669924161 hsa-miR-330-3p PRKX 0.0475489583333344 0.000859543426581515 0.0295582203370106 0.735259443898609 MirTarget -1.20850351634044 0.00767246696321265 hsa-miR-331-3p TCF7 0.142898958333333 1.85230841027855e-08 0.154560177240034 0.211770647214088 MirTarget;miRNATAP -0.74496767493483 0.0291179510157844 hsa-miR-33a-5p PRICKLE2 0.159034374999999 2.69680061078e-07 -0.710410295531476 1.70850958175018e-05 MirTarget -2.70416448526994 4.94237764880526e-14 hsa-miR-340-3p FZD2 0.0314968750000001 0.187919504901725 -0.0147186727874633 0.702074936835482 MirTarget -0.331105258858775 0.00405690326998544 hsa-miR-346 PRICKLE2 0.0869833333333349 1.21597589588412e-05 -0.710410295531476 1.70850958175018e-05 MirTarget;miRanda;miRNATAP -3.4613774002674 3.87566050120671e-09 hsa-miR-34b-5p DAAM1 0.106034375000001 0.00022824345015252 -0.09736079888477 0.257360845225757 MirTarget;miRNATAP -0.65176009183261 0.00210481918999088 hsa-miR-34b-5p NFAT5 0.106034375000001 0.00022824345015252 -0.117746017099222 0.309971021909308 MirTarget;miRNATAP -0.647259220479453 0.0245569572794177 hsa-miR-34c-5p PPP2R5A 0.200814583333336 5.32673441685204e-05 0.0231605922470068 0.523579611581263 MirTarget;PITA;miRanda;miRNATAP -0.130418739757144 0.0101282837001358 hsa-miR-34c-5p DAAM1 0.200814583333336 5.32673441685204e-05 -0.09736079888477 0.257360845225757 MirTarget;PITA;miRanda;miRNATAP -0.380605628977365 0.00169973711396609 hsa-miR-363-3p CAMK2A 0.0402572916666674 0.285465416838525 0.154859457150701 0.0544358635832875 MirTarget -0.339274466960907 0.0282484481560684 hsa-miR-370-3p PRKACB 0.0287135416666671 0.210944141240192 -0.138667096100081 0.140617869700975 MirTarget -1.44989144543619 6.97374314323394e-07 hsa-miR-373-5p TBL1XR1 -0.119583333333332 0.00146942333136967 0.190962309927984 0.0376557917240184 MirTarget;mirMAP -0.350666835168997 0.0454632660529672 hsa-miR-373-5p FZD2 -0.119583333333332 0.00146942333136967 -0.0147186727874633 0.702074936835482 MirTarget -0.187490430812881 0.00912035160443795 hsa-miR-376a-3p PPP2R5A -0.071173958333333 0.24451007780002 0.0231605922470068 0.523579611581263 MirTarget -0.109036399314952 0.00935390075520912 hsa-miR-376a-3p PRKACB -0.071173958333333 0.24451007780002 -0.138667096100081 0.140617869700975 MirTarget;TargetScan -0.263305498086585 0.0173228790352622 hsa-miR-376b-3p PPP2R5A -0.0304520833333324 0.634442506424438 0.0231605922470068 0.523579611581263 MirTarget -0.104503140272913 0.00917993063689157 hsa-miR-376b-3p PRKACB -0.0304520833333324 0.634442506424438 -0.138667096100081 0.140617869700975 MirTarget -0.210900959813042 0.0466786023377359 hsa-miR-376c-3p PPP2R5A -0.0703572916666665 0.16259714653536 0.0231605922470068 0.523579611581263 MirTarget -0.114701524485603 0.02468708831746 hsa-miR-376c-3p CREBBP -0.0703572916666665 0.16259714653536 -0.0398713366728938 0.332668797640848 MirTarget -0.153135247946836 0.00826252866376411 hsa-miR-376c-3p WNT3 -0.0703572916666665 0.16259714653536 0.0595096808011224 0.532006379818058 MirTarget -0.306358735172921 0.0240158601089585 hsa-miR-377-3p CUL1 -0.0218406249999997 0.661697016770062 0.620515023663135 1.82070009279316e-08 MirTarget -0.548573298228133 0.000845077773653131 hsa-miR-377-3p FZD4 -0.0218406249999997 0.661697016770062 0.0472296826427225 0.558273177603475 MirTarget -0.465595040646113 4.80087834656516e-05 hsa-miR-378a-3p WNT10A -0.134870833333334 0.0107938354842622 -0.0982836421915616 0.286048482573024 MirTarget;miRNATAP -0.343884504836707 0.00553948403212344 hsa-miR-378a-5p VANGL2 -0.185940625 9.58922808820003e-06 -0.356510038890634 0.113213829021286 MirTarget -1.71586413532553 3.64661113425479e-06 hsa-miR-381-3p PRKACB 0.0574104166666668 0.0371692809280114 -0.138667096100081 0.140617869700975 MirTarget -1.03379152843663 2.13127035475991e-05 hsa-miR-382-5p PPP3CC 0.00236041666666886 0.972714669796904 -0.0558324235696945 0.0670610277534223 MirTarget -0.0635052632396613 0.0423084069862906 hsa-miR-422a WNT10A 0.0441739583333365 0.0785288792652128 -0.0982836421915616 0.286048482573024 MirTarget;miRNATAP -0.775787125056633 0.00344687810494753 hsa-miR-424-5p TBL1XR1 -0.163364583333334 2.62229410811717e-07 0.190962309927984 0.0376557917240184 MirTarget -0.894607364361661 7.45865087551992e-06 hsa-miR-429 RHOA -0.0799427083333338 0.00239378361551957 0.0900101512527449 3.597321051434e-05 MirTarget;PITA;miRanda;miRNATAP -0.138102741682021 0.0177686930119754 hsa-miR-429 TBL1XR1 -0.0799427083333338 0.00239378361551957 0.190962309927984 0.0376557917240184 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.604493597243429 0.0163793962163987 hsa-miR-448 MAP3K7 0.029692708333334 0.16644209566908 0.197672808642468 0.0112927777039728 MirTarget;PITA;miRanda;miRNATAP -0.909958510808515 0.000603055254323061 hsa-miR-452-5p NFATC2 0.0885708333333341 0.000606518257781443 -0.211033921703619 0.0515244993059601 MirTarget;miRNATAP -1.69640536578365 5.63053303056119e-09 hsa-miR-452-5p DAAM1 0.0885708333333341 0.000606518257781443 -0.09736079888477 0.257360845225757 MirTarget -0.890752868842009 0.0001583843915795 hsa-miR-7-5p NFATC2 0.112319791666666 6.89435265439898e-05 -0.211033921703619 0.0515244993059601 MirTarget;miRNATAP -0.751328362850462 0.00603678564509538 hsa-miR-96-5p PPP3R1 0.249976041666667 0.00238507891968062 0.0189274812228692 0.752755399526254 MirTarget;TargetScan;miRNATAP -0.118743311713044 0.0214145896176332 hsa-miR-99a-5p FZD5 -0.175518750000001 0.00013917372253539 0.156615075177879 0.0518533853849842 MirTarget;miRNATAP -0.379301093305795 0.00210842495896335 hsa-miR-206 CTBP2 0.0323270833333327 0.132508035975732 -0.596087796624309 6.73554945917246e-08 PITA;miRanda -1.95716913422403 2.42915438693348e-07 hsa-miR-448 CTBP2 0.029692708333334 0.16644209566908 -0.596087796624309 6.73554945917246e-08 PITA;miRanda -2.46562676901669 3.19136546922812e-11 hsa-miR-188-5p CCND2 0.231419791666667 8.71778886104107e-13 -0.0166722150535952 0.799625753551218 PITA;mirMAP -0.371026174437323 0.00666705196445588 hsa-miR-199a-5p GSK3B -0.439753125000001 5.11264621396001e-10 0.103984137985218 0.0904143607181575 PITA;miRanda;miRNATAP -0.188867893063043 0.00136549299029166 hsa-miR-199b-5p GSK3B -0.220826041666666 0.000676554402277228 0.103984137985218 0.0904143607181575 PITA;miRanda;miRNATAP -0.219224927590692 0.000969907345548547 hsa-miR-330-3p LRP6 0.0475489583333344 0.000859543426581515 -0.149405434713309 0.015290121892894 PITA;mirMAP;miRNATAP -0.764139673622052 0.0174880462178214 hsa-miR-193a-3p PPP2R5C 0.0943291666666665 0.0034681283330623 -0.150909959174399 0.0114911146917879 PITA;miRanda;miRNATAP -0.33105119485139 0.012709217051359 hsa-miR-330-3p MAPK10 0.0475489583333344 0.000859543426581515 -0.403891331278732 8.38548943358056e-08 PITA;miRNATAP -2.62153521507947 1.01168169013577e-11 hsa-miR-188-5p WNT10B 0.231419791666667 8.71778886104107e-13 -0.0873257085563885 0.0153397452923544 PITA -0.19247906934374 0.0100769452442397 hsa-miR-342-3p FZD5 0.0121989583333333 0.814558160538235 0.156615075177879 0.0518533853849842 PITA -0.291199683479203 0.00908993636391021 hsa-miR-299-3p CUL1 -0.0750937499999992 0.133916719346714 0.620515023663135 1.82070009279316e-08 PITA;miRanda -0.688161321945074 2.11572916474235e-05 hsa-miR-199a-3p BTRC -0.473138541666669 2.11211326609588e-10 0.115058906471312 0.0399921555489253 PITA -0.154904453771631 0.00243591223795416 hsa-miR-125a-5p DVL3 -0.127755208333335 0.000138704165746353 0.114446993590549 0.000831052646869237 PITA -0.349576398117042 7.4070379000339e-07 hsa-miR-142-3p ROCK2 -0.061707291666669 0.145842401503657 0.23797083238613 0.000133129181518868 PITA;miRanda;miRNATAP -0.226251438747666 0.0350252099678823 hsa-miR-142-5p ROCK2 -0.118083333333333 0.00782838989880578 0.23797083238613 0.000133129181518868 PITA -0.230984475552012 0.0232058973058678 hsa-miR-34c-5p FOSL1 0.200814583333336 5.32673441685204e-05 -0.543265687537282 0.00108910764212718 PITA;miRanda;miRNATAP -0.690418097972632 0.0037915594044622 hsa-miR-198 NFAT5 -0.00236354166666586 0.968949868484192 -0.117746017099222 0.309971021909308 PITA -0.664642830218082 7.24502289402178e-07 hsa-miR-320a RAC1 0.0244749999999987 0.226230360993065 0.120957872181554 0.000358597454614627 PITA;miRanda;miRNATAP -0.306822272042815 0.0124641425178523 hsa-miR-449a DKK1 0.0338000000000005 0.112855788380633 1.10210291263388 0.000275551601099095 PITA;miRanda -5.11795180087866 6.99431416482446e-07 hsa-miR-369-3p FBXW11 0.0611989583333324 0.0174042479557122 0.103076252948277 0.0132185858141707 PITA;mirMAP;miRNATAP -0.259264289990254 0.0261475406237359 hsa-miR-137 PLCB1 0.0312114583333318 0.288380289785221 0.803184556911579 2.54367115402579e-06 PITA;miRanda;miRNATAP -0.966943929349909 0.0256887590204224 hsa-miR-199a-3p PLCB1 -0.473138541666669 2.11211326609588e-10 0.803184556911579 2.54367115402579e-06 PITA -0.836789420579528 8.64350869902651e-08 hsa-miR-142-5p CAMK2A -0.118083333333333 0.00782838989880578 0.154859457150701 0.0544358635832875 PITA;miRNATAP -0.408380513998203 0.00156386889210591 hsa-miR-422a VANGL2 0.0441739583333365 0.0785288792652128 -0.356510038890634 0.113213829021286 PITA;miRanda -1.6366284676228 0.0121273522764357 hsa-miR-107 WNT4 0.133714583333333 2.23857195703982e-06 -0.536523080512791 0.000660223576486418 PITA;miRNATAP -1.34056975913221 0.000712678183496037 hsa-miR-142-5p TCF7L1 -0.118083333333333 0.00782838989880578 0.0338709240316986 0.578190497535283 PITA -0.29861852960662 0.00210192267093754 hsa-miR-199a-3p VANGL1 -0.473138541666669 2.11211326609588e-10 0.114511596030802 0.21590508129194 PITA -0.25765017305484 0.00228287780021258 hsa-miR-154-3p APC -0.0302083333333325 0.698129908482012 0.0471771018660387 0.429776421832463 TargetScan -0.134470974168575 0.0142423591792217 hsa-miR-96-5p DAAM1 0.249976041666667 0.00238507891968062 -0.09736079888477 0.257360845225757 TargetScan;miRNATAP -0.351795902378521 1.18963687204025e-06 hsa-miR-17-5p FZD4 0.0594531249999994 0.0577784446787179 0.0472296826427225 0.558273177603475 TargetScan -0.457830252107115 0.0134504883719077 hsa-miR-96-5p LRP6 0.249976041666667 0.00238507891968062 -0.149405434713309 0.015290121892894 TargetScan;miRNATAP -0.183346247301328 0.000523948084736415 hsa-miR-96-5p PPP3CA 0.249976041666667 0.00238507891968062 -0.163058424706868 0.00164514523193859 TargetScan -0.183651939366856 3.37722622484287e-05 hsa-miR-17-5p PRKACB 0.0594531249999994 0.0577784446787179 -0.138667096100081 0.140617869700975 TargetScan -0.599481601210584 0.00558474009083522 hsa-miR-200b-3p PRKCA -0.525884375 1.04581265194109e-09 0.185818287677706 0.0154752151667042 TargetScan -0.140217462720274 0.0222913667765747 hsa-miR-200b-3p RAC1 -0.525884375 1.04581265194109e-09 0.120957872181554 0.000358597454614627 TargetScan -0.0553963529324227 0.0400721720545041 hsa-miR-200b-3p ROCK2 -0.525884375 1.04581265194109e-09 0.23797083238613 0.000133129181518868 TargetScan -0.123984238775296 0.0135440083729877 hsa-miR-376a-3p SENP2 -0.071173958333333 0.24451007780002 0.153793745225116 0.00900042829073861 TargetScan -0.140780102631468 0.0429155024737227 hsa-let-7a-5p SMAD2 -0.0304750000000005 0.2544201287335 0.233004999272719 0.0002706418147499 TargetScan -0.683013350659073 8.49300047448072e-05 hsa-let-7a-5p VANGL2 -0.0304750000000005 0.2544201287335 -0.356510038890634 0.113213829021286 TargetScan;miRNATAP -1.57998225580575 0.00991589552182636 hsa-miR-302a-3p WNT9A 0.0161916666666673 0.580309964436337 -0.589303230232116 5.86011641157039e-05 TargetScan -0.80293793751031 0.030631746174997 hsa-miR-28-5p CTNNB1 0.00902187499999979 0.573961937625452 0.212559188026568 0.0205459028691703 miRanda -1.09374793297582 0.0106605101846392 hsa-miR-107 WNT16 0.133714583333333 2.23857195703982e-06 0.0105083868778078 0.719104718803634 miRanda;miRNATAP -0.161403729406253 0.0234647636503948 hsa-miR-107 VANGL2 0.133714583333333 2.23857195703982e-06 -0.356510038890634 0.113213829021286 miRanda -1.94557998348585 0.000500500968126483 hsa-miR-199a-5p FBXW11 -0.439753125000001 5.11264621396001e-10 0.103076252948277 0.0132185858141707 miRanda -0.0792535733592781 0.0486855767174456 hsa-miR-199a-5p MAPK9 -0.439753125000001 5.11264621396001e-10 0.11555201208399 0.0380112767490297 miRanda -0.181691189169438 0.000674335950143057 hsa-miR-199a-5p WIF1 -0.439753125000001 5.11264621396001e-10 0.363650077730341 0.0145591465276953 miRanda -0.563559335883922 8.32225303119543e-05 hsa-miR-199a-5p PPP2R1A -0.439753125000001 5.11264621396001e-10 0.188887135965384 0.000948166169007954 miRanda -0.213970875784083 0.000102264641790689 hsa-miR-129-5p TCF7L2 -0.00798437499999771 0.794722371016669 -0.12476485755165 0.075666606325994 miRanda -0.370022238296742 0.0259785757678209 hsa-miR-129-5p MAPK8 -0.00798437499999771 0.794722371016669 -0.171765768887781 0.0118048295600565 miRanda -0.325509594874085 0.0448278188205915 hsa-miR-129-5p SFRP4 -0.00798437499999771 0.794722371016669 0.723042010172955 0.0177187855512114 miRanda -1.49466609162616 0.0398801015211792 hsa-miR-129-5p PRKX -0.00798437499999771 0.794722371016669 0.0295582203370106 0.735259443898609 miRanda;mirMAP -0.40712903677815 0.0487860166521397 hsa-miR-139-5p PLCB1 -0.0753822916666668 0.00238689962038074 0.803184556911579 2.54367115402579e-06 miRanda -3.95249387572059 3.56120599450911e-17 hsa-miR-139-5p NLK -0.0753822916666668 0.00238689962038074 0.17841787778347 0.00756701122609011 miRanda -0.43225159606732 0.0267261618127056 hsa-miR-139-5p VANGL2 -0.0753822916666668 0.00238689962038074 -0.356510038890634 0.113213829021286 miRanda -3.02564133998281 2.39979513171158e-06 hsa-miR-139-5p FZD6 -0.0753822916666668 0.00238689962038074 0.197084128682963 0.170965211951985 miRanda -1.21922144734639 0.00346308802473023 hsa-miR-139-5p EP300 -0.0753822916666668 0.00238689962038074 0.106443973458177 0.0571948587983776 miRanda -1.04679897264655 1.05275745795939e-11 hsa-miR-139-5p VANGL1 -0.0753822916666668 0.00238689962038074 0.114511596030802 0.21590508129194 miRanda -0.605074388126609 0.0243974184404258 hsa-miR-139-5p RBX1 -0.0753822916666668 0.00238689962038074 0.0783043133932377 0.0380127178572894 miRanda -0.63512691272891 1.12875420771177e-09 hsa-miR-199b-5p SMAD4 -0.220826041666666 0.000676554402277228 -0.0193483612021588 0.537991502197394 miRanda -0.108599934898669 0.00113229624253862 hsa-miR-199b-5p WIF1 -0.220826041666666 0.000676554402277228 0.363650077730341 0.0145591465276953 miRanda -0.54447547749969 0.00079837273265824 hsa-miR-199b-5p FRAT1 -0.220826041666666 0.000676554402277228 0.316403375622135 0.00137123458861494 miRanda -0.364816917888806 0.000755321713831908 hsa-miR-217 CTBP2 0.0874812500000005 0.117292906648424 -0.596087796624309 6.73554945917246e-08 miRanda -0.535696023678202 0.000234831185415307 hsa-miR-217 CAMK2D 0.0874812500000005 0.117292906648424 -0.200760394239715 0.00604513510738709 miRanda -0.21066805592681 0.0260443918479977 hsa-miR-217 PLCB4 0.0874812500000005 0.117292906648424 0.0132319084858308 0.785919194854058 miRanda -0.139929743233482 0.0243076883378489 hsa-miR-217 PRICKLE2 0.0874812500000005 0.117292906648424 -0.710410295531476 1.70850958175018e-05 miRanda -0.833457413112669 0.000103690626214514 hsa-miR-137 TBL1XR1 0.0312114583333318 0.288380289785221 0.190962309927984 0.0376557917240184 miRanda;mirMAP -0.734989726169622 0.00113856628632805 hsa-miR-137 MMP7 0.0312114583333318 0.288380289785221 -1.39655921036109 2.78115729488154e-05 miRanda -2.46998311908127 0.00318368989762648 hsa-miR-137 DKK1 0.0312114583333318 0.288380289785221 1.10210291263388 0.000275551601099095 miRanda -1.58453790111717 0.0374572965276878 hsa-miR-137 DKK2 0.0312114583333318 0.288380289785221 0.289580160909749 0.0557020653186319 miRanda -0.784405542507867 0.0366705768545858 hsa-miR-137 PPP2R5E 0.0312114583333318 0.288380289785221 -0.0680113241094285 0.488239722399933 miRanda -0.873544809704567 0.000261281893264509 hsa-miR-142-3p SENP2 -0.061707291666669 0.145842401503657 0.153793745225116 0.00900042829073861 miRanda -0.424419189679845 1.65246995394843e-05 hsa-miR-142-3p NLK -0.061707291666669 0.145842401503657 0.17841787778347 0.00756701122609011 miRanda -0.271990584910088 0.0169263697295286 hsa-miR-142-3p SIAH1 -0.061707291666669 0.145842401503657 -0.219570225447566 0.0197162099016641 miRanda -0.32489750866087 0.0434478008254993 hsa-miR-142-3p CACYBP -0.061707291666669 0.145842401503657 0.422038682623345 1.39499697971974e-06 miRanda -0.504996793449574 0.000855051275709556 hsa-miR-125a-5p NKD1 -0.127755208333335 0.000138704165746353 0.540732009903865 0.0360085175790133 miRanda -1.66506438976747 0.00233648610892002 hsa-miR-125a-5p PORCN -0.127755208333335 0.000138704165746353 0.284460470840869 2.39442404493328e-05 miRanda -0.537665298485241 0.000185945994595326 hsa-miR-125a-5p CTNNB1 -0.127755208333335 0.000138704165746353 0.212559188026568 0.0205459028691703 miRanda -0.394843096560729 0.0437767903593363 hsa-miR-125a-5p NLK -0.127755208333335 0.000138704165746353 0.17841787778347 0.00756701122609011 miRanda -0.354538194182761 0.0126414627697126 hsa-miR-125a-5p DVL2 -0.127755208333335 0.000138704165746353 0.392328080664631 8.7563438221752e-08 miRanda -0.879289182162274 1.48807989355658e-08 hsa-miR-184 RAC2 0.211478125000001 2.26890637509929e-05 -0.58880100295462 2.16824201752923e-05 miRanda -1.15850810131234 1.68322184671523e-09 hsa-miR-184 PRICKLE1 0.211478125000001 2.26890637509929e-05 -0.857244431292353 8.05438071206138e-08 miRanda -1.63755181448609 7.94137456223696e-14 hsa-miR-184 PRICKLE2 0.211478125000001 2.26890637509929e-05 -0.710410295531476 1.70850958175018e-05 miRanda -0.972198027268198 3.53269948016438e-05 hsa-miR-184 SFRP1 0.211478125000001 2.26890637509929e-05 -0.918311685823821 4.23744371853458e-08 miRanda -1.14790994059537 1.75064639395801e-06 hsa-miR-193a-3p TCF7L2 0.0943291666666665 0.0034681283330623 -0.12476485755165 0.075666606325994 miRanda -0.333533093401474 0.0327391507635048 hsa-miR-193a-3p MAPK10 0.0943291666666665 0.0034681283330623 -0.403891331278732 8.38548943358056e-08 miRanda;miRNATAP -0.64589730249275 0.000161161695481961 hsa-miR-193a-3p DAAM2 0.0943291666666665 0.0034681283330623 -0.180255861829957 0.0353055854211658 miRanda -0.613954965793265 0.00120029086085072 hsa-miR-193a-3p PRKACB 0.0943291666666665 0.0034681283330623 -0.138667096100081 0.140617869700975 miRanda -0.791203595206497 0.000128983621116077 hsa-miR-193a-3p PLCB2 0.0943291666666665 0.0034681283330623 -0.379934521876681 4.77529751942389e-07 miRanda -0.656900718890706 0.000116800086414275 hsa-miR-206 TCF7L2 0.0323270833333327 0.132508035975732 -0.12476485755165 0.075666606325994 miRanda;miRNATAP -0.568256268481194 0.0174332715848886 hsa-miR-206 EP300 0.0323270833333327 0.132508035975732 0.106443973458177 0.0571948587983776 miRanda -0.401201004555018 0.0351349690091573 hsa-miR-206 PRICKLE2 0.0323270833333327 0.132508035975732 -0.710410295531476 1.70850958175018e-05 miRanda -1.95289942597038 0.00062513522729111 hsa-miR-320a CACYBP 0.0244749999999987 0.226230360993065 0.422038682623345 1.39499697971974e-06 miRanda -0.916278172283444 0.00486153479259146 hsa-miR-34c-5p SMAD4 0.200814583333336 5.32673441685204e-05 -0.0193483612021588 0.537991502197394 miRanda;miRNATAP -0.158049676261866 0.000258559075930679 hsa-miR-34c-5p CAMK2D 0.200814583333336 5.32673441685204e-05 -0.200760394239715 0.00604513510738709 miRanda -0.285241459716711 0.00620952495223084 hsa-miR-34c-5p DAAM2 0.200814583333336 5.32673441685204e-05 -0.180255861829957 0.0353055854211658 miRanda -0.618437711538441 1.85475879147481e-07 hsa-miR-34c-5p CCND1 0.200814583333336 5.32673441685204e-05 -0.489663700767601 0.00116327564880174 miRanda;miRNATAP -0.856529563655122 6.25811196851031e-05 25064703 We found that expression levels of the known cell cycle-regulating miR-34 targets CCND1 CDK4 and CDK6 were downregulated upon miR-34c expression in breast cancer cell lines breast cancer hsa-miR-34c-5p AXIN2 0.200814583333336 5.32673441685204e-05 0.000123812425103065 0.997690310539718 miRanda -0.128378565717731 0.0327934197592937 hsa-miR-299-3p SENP2 -0.0750937499999992 0.133916719346714 0.153793745225116 0.00900042829073861 miRanda -0.206421304342345 0.0147895395612349 hsa-miR-299-3p DVL3 -0.0750937499999992 0.133916719346714 0.114446993590549 0.000831052646869237 miRanda -0.123651192269502 0.0115008095257749 hsa-miR-299-3p APC -0.0750937499999992 0.133916719346714 0.0471771018660387 0.429776421832463 miRanda -0.171457569292307 0.0448539523113423 hsa-miR-299-3p FZD4 -0.0750937499999992 0.133916719346714 0.0472296826427225 0.558273177603475 miRanda -0.356431432468192 0.00190814516183607 hsa-miR-375 CSNK2A1 -0.553344791666666 8.52426333986314e-09 0.290677885621728 0.00160379724667918 miRanda -0.175166001004682 0.00857683110208702 hsa-miR-375 CSNK1E -0.553344791666666 8.52426333986314e-09 0.278817302483912 0.00101487072640408 miRanda -0.248556573435384 4.13124915164234e-05 hsa-miR-375 MAP3K7 -0.553344791666666 8.52426333986314e-09 0.197672808642468 0.0112927777039728 miRanda -0.174531320431956 0.00180172672211195 hsa-miR-375 SFRP4 -0.553344791666666 8.52426333986314e-09 0.723042010172955 0.0177187855512114 miRanda -0.517872787315191 0.0186782452326213 hsa-miR-342-3p TCF7L2 0.0121989583333333 0.814558160538235 -0.12476485755165 0.075666606325994 miRanda -0.21534532398058 0.0270428642545548 hsa-miR-326 SMAD3 -0.0456083333333334 0.108670355811767 0.252092893656572 0.00235787885298325 miRanda -0.831540098971387 7.72701987305243e-05 hsa-miR-326 EP300 -0.0456083333333334 0.108670355811767 0.106443973458177 0.0571948587983776 miRanda -0.316839197259847 0.0261494499181368 hsa-miR-324-5p WNT2 0.232380208333334 1.48861851476432e-08 -0.908591483294797 1.27750228597462e-10 miRanda -1.78032996231539 3.80609131364993e-14 hsa-miR-338-3p PPP2R5D -0.120344791666666 0.00224547965794864 0.357614172953129 1.46589895140722e-09 miRanda -0.255797027922223 0.0221094369645998 hsa-miR-338-3p APC -0.120344791666666 0.00224547965794864 0.0471771018660387 0.429776421832463 miRanda -0.30354308770568 0.00472077516644366 hsa-miR-339-5p WNT16 0.141184375 1.23879495630912e-08 0.0105083868778078 0.719104718803634 miRanda -0.166277528744171 0.0389466597412581 hsa-miR-339-5p NFATC3 0.141184375 1.23879495630912e-08 -0.197504610403103 0.000313375676516591 miRanda -0.480787280974925 0.00196467879980932 hsa-miR-339-5p SFRP5 0.141184375 1.23879495630912e-08 -1.96217629356525 3.98680310767494e-12 miRanda -6.98559061738476 1.07117163840295e-19 hsa-miR-339-5p PLCB2 0.141184375 1.23879495630912e-08 -0.379934521876681 4.77529751942389e-07 miRanda -1.58162953635809 1.01251302074635e-14 hsa-miR-133b PPP2R5D -0.124987499999999 0.0111187647147627 0.357614172953129 1.46589895140722e-09 miRanda -0.334818540014684 0.000154867928229521 hsa-miR-346 TCF7L2 0.0869833333333349 1.21597589588412e-05 -0.12476485755165 0.075666606325994 miRanda -0.532735167422523 0.0358753460800789 hsa-miR-346 MMP7 0.0869833333333349 1.21597589588412e-05 -1.39655921036109 2.78115729488154e-05 miRanda -8.96559750370402 5.03901210526238e-15 hsa-miR-346 SFRP4 0.0869833333333349 1.21597589588412e-05 0.723042010172955 0.0177187855512114 miRanda;miRNATAP -2.32779220040952 0.0359979072398827 hsa-miR-384 CSNK2B -0.000405208333332574 0.99015192340482 0.107469995031789 0.00730441863958066 miRanda -0.184098493911142 0.0370070751202041 hsa-miR-384 CTNNB1 -0.000405208333332574 0.99015192340482 0.212559188026568 0.0205459028691703 miRanda -0.420200533368547 0.0392804591927603 hsa-miR-384 DKK2 -0.000405208333332574 0.99015192340482 0.289580160909749 0.0557020653186319 miRanda -1.14964442872604 0.00054726018264541 hsa-miR-384 SFRP4 -0.000405208333332574 0.99015192340482 0.723042010172955 0.0177187855512114 miRanda -1.96764374973894 0.00356941091011996 hsa-miR-422a PRICKLE1 0.0441739583333365 0.0785288792652128 -0.857244431292353 8.05438071206138e-08 miRanda -2.45507808807933 1.34605670562253e-07 hsa-miR-422a SFRP1 0.0441739583333365 0.0785288792652128 -0.918311685823821 4.23744371853458e-08 miRanda -2.00690891142795 5.29428129388074e-05 hsa-miR-448 PLCB1 0.029692708333334 0.16644209566908 0.803184556911579 2.54367115402579e-06 miRanda;miRNATAP -1.85949503406003 0.00179191946865509 hsa-miR-448 CTNNB1 0.029692708333334 0.16644209566908 0.212559188026568 0.0205459028691703 miRanda -1.35079261273204 1.22625583317045e-05 hsa-miR-448 EP300 0.029692708333334 0.16644209566908 0.106443973458177 0.0571948587983776 miRanda -0.68394288811896 0.000288440508162638 hsa-miR-448 MMP7 0.029692708333334 0.16644209566908 -1.39655921036109 2.78115729488154e-05 miRanda -5.56698178632234 9.31798198960236e-07 hsa-miR-448 FZD8 0.029692708333334 0.16644209566908 -0.263289416025741 0.048690560726977 miRanda -1.04905940658699 0.0218465865537442 hsa-miR-448 PRKX 0.029692708333334 0.16644209566908 0.0295582203370106 0.735259443898609 miRanda -1.59984828806033 2.69884408079039e-08 hsa-miR-429 NLK -0.0799427083333338 0.00239378361551957 0.17841787778347 0.00756701122609011 miRanda;miRNATAP -0.56580891480789 0.00192969478580758 hsa-miR-429 WIF1 -0.0799427083333338 0.00239378361551957 0.363650077730341 0.0145591465276953 miRanda -0.943818932773211 0.0212549365527837 hsa-miR-449a PLCB1 0.0338000000000005 0.112855788380633 0.803184556911579 2.54367115402579e-06 miRanda;miRNATAP -1.42838944327516 0.0177184708020059 hsa-miR-449a NFATC4 0.0338000000000005 0.112855788380633 0.126331695415399 0.0640387076256883 miRanda -1.02596679325225 7.96791436491144e-06 hsa-miR-449a EP300 0.0338000000000005 0.112855788380633 0.106443973458177 0.0571948587983776 miRanda -0.632052247421809 0.000896734483618724 hsa-miR-449a NKD2 0.0338000000000005 0.112855788380633 -0.600778198113319 0.000217134768563009 miRanda -1.77106775509415 0.0016808212985784 hsa-miR-142-5p CREBBP -0.118083333333333 0.00782838989880578 -0.0398713366728938 0.332668797640848 mirMAP -0.252844437144433 9.36242480191045e-05 hsa-miR-224-5p CREBBP 0.354696875 6.17656280490302e-05 -0.0398713366728938 0.332668797640848 mirMAP -0.0846502635868565 0.00882124361384771 hsa-miR-147a CAMK2B 0.0934770833333343 0.00179214699390234 -0.845476560565095 1.72449919556697e-07 mirMAP -1.21945487118568 0.00223682582899764 hsa-miR-18a-5p CAMK2B 0.195905208333333 7.199331158466e-05 -0.845476560565095 1.72449919556697e-07 mirMAP -1.78321166549452 1.04910783854895e-15 hsa-miR-193a-3p CAMK2B 0.0943291666666665 0.0034681283330623 -0.845476560565095 1.72449919556697e-07 mirMAP -1.44953707244412 7.84260885077745e-05 hsa-miR-205-5p CAMK2B 0.0115270833333347 0.710545677344024 -0.845476560565095 1.72449919556697e-07 mirMAP -1.03282488691131 0.00813245247324673 hsa-miR-34a-5p CAMK2B 0.0815322916666636 0.0361955645073578 -0.845476560565095 1.72449919556697e-07 mirMAP -0.616037017446745 0.046749464145702 hsa-miR-377-3p CAMK2B -0.0218406249999997 0.661697016770062 -0.845476560565095 1.72449919556697e-07 mirMAP -0.696327786714661 0.00384520632581249 hsa-miR-96-5p CAMK2B 0.249976041666667 0.00238507891968062 -0.845476560565095 1.72449919556697e-07 mirMAP -0.764713598927505 4.80994175246304e-08 hsa-miR-181a-5p LRP6 -0.0178312500000008 0.504202611435176 -0.149405434713309 0.015290121892894 mirMAP -0.494258760636637 0.00318500842405903 hsa-miR-181b-5p LRP6 0.0355343749999995 0.181114970996306 -0.149405434713309 0.015290121892894 mirMAP -0.645517992080948 0.000108121396395652 hsa-miR-181c-5p LRP6 -0.0391416666666661 0.24873704977008 -0.149405434713309 0.015290121892894 mirMAP -0.427681971631277 0.0010623641937379 hsa-miR-302c-5p LRP6 0.0869791666666674 0.0136966249723328 -0.149405434713309 0.015290121892894 mirMAP -0.364801726475929 0.00356115373930844 hsa-miR-93-5p LRP6 0.188120833333332 2.87978994240045e-10 -0.149405434713309 0.015290121892894 mirMAP -0.550038220439447 9.47177245429433e-05 hsa-miR-9-3p LRP6 0.169132291666668 0.0035773401279874 -0.149405434713309 0.015290121892894 mirMAP;miRNATAP -0.267059818029784 0.000373162370665562 hsa-miR-30b-5p CSNK2A2 0.0675958333333311 0.0250792126411936 0.06215601757496 0.293610338719952 mirMAP -0.332968748259699 0.0180399405294674 hsa-miR-373-5p CSNK2A2 -0.119583333333332 0.00146942333136967 0.06215601757496 0.293610338719952 mirMAP -0.254427001923744 0.0229743078386548 hsa-miR-27a-3p CAMK2A -0.00334791666666856 0.862458239652667 0.154859457150701 0.0544358635832875 mirMAP;miRNATAP -0.960095718462919 0.00170759469546336 hsa-miR-216a-5p NFATC3 0.166075000000001 0.000626168179963556 -0.197504610403103 0.000313375676516591 mirMAP -0.174742509115097 0.0311264741838423 hsa-miR-142-5p GSK3B -0.118083333333333 0.00782838989880578 0.103984137985218 0.0904143607181575 mirMAP;miRNATAP -0.254479694216607 0.00984509810274106 hsa-miR-181a-5p GSK3B -0.0178312500000008 0.504202611435176 0.103984137985218 0.0904143607181575 mirMAP -0.504915447500318 0.00239559325301461 hsa-miR-181b-5p GSK3B 0.0355343749999995 0.181114970996306 0.103984137985218 0.0904143607181575 mirMAP -0.40259180204241 0.0162821714473253 hsa-miR-181c-5p GSK3B -0.0391416666666661 0.24873704977008 0.103984137985218 0.0904143607181575 mirMAP -0.296925970305961 0.0230794988737165 hsa-miR-19b-3p GSK3B -0.0232406250000019 0.402772271458001 0.103984137985218 0.0904143607181575 mirMAP -0.366305225406397 0.0224332282505354 hsa-miR-181b-5p DAAM1 0.0355343749999995 0.181114970996306 -0.09736079888477 0.257360845225757 mirMAP -0.610878217638242 0.00915084293340626 hsa-miR-105-5p NFATC4 0.172322916666667 0.00159136123673933 0.126331695415399 0.0640387076256883 mirMAP -0.193876437139664 0.0293812001300671 hsa-miR-125b-5p NFATC4 -0.187647916666668 1.01964050843717e-05 0.126331695415399 0.0640387076256883 mirMAP -0.258902688178766 0.0219530148381768 hsa-miR-126-5p NFATC2 0.00174583333333045 0.93995162076006 -0.211033921703619 0.0515244993059601 mirMAP -1.26261191030961 0.000199837834944383 hsa-miR-182-5p NFATC2 0.137020833333333 0.00166040840475327 -0.211033921703619 0.0515244993059601 mirMAP -0.414637981348944 0.0197557944372739 hsa-miR-186-5p NFATC2 0.119613541666665 4.08271418900568e-07 -0.211033921703619 0.0515244993059601 mirMAP -1.69699554189328 7.57222335481917e-08 hsa-miR-374a-5p NFATC2 0.0364093749999981 0.144216889364782 -0.211033921703619 0.0515244993059601 mirMAP -1.58554507874018 2.8286340817798e-07 hsa-miR-26a-5p CSNK2A1 -0.0802614583333372 6.57714639384254e-05 0.290677885621728 0.00160379724667918 mirMAP -0.818874324730969 0.0140160785637561 hsa-miR-26b-5p CSNK2A1 -0.0469791666666701 0.0492766500438207 0.290677885621728 0.00160379724667918 mirMAP -0.76820607828699 0.00655367052127336 hsa-miR-373-5p CSNK2A1 -0.119583333333332 0.00146942333136967 0.290677885621728 0.00160379724667918 mirMAP -0.606594083294531 0.000537296101453335 hsa-miR-135b-5p TBL1X -0.108287499999999 0.00127396707132353 0.309411886883789 0.00218320488622219 mirMAP -0.779947505707842 0.000281267515659582 hsa-miR-23a-3p TBL1X -0.0224822916666669 0.180920975137738 0.309411886883789 0.00218320488622219 mirMAP -1.40056870343455 0.00177753388914812 hsa-miR-23b-3p TBL1X 0.00990312499999879 0.577638557352371 0.309411886883789 0.00218320488622219 mirMAP -0.982422643474648 0.0208365223259543 hsa-miR-374a-5p NFAT5 0.0364093749999981 0.144216889364782 -0.117746017099222 0.309971021909308 mirMAP;miRNATAP -1.40169745041787 2.56369316702291e-05 hsa-miR-19a-3p FZD3 0.0212885416666653 0.477294105669598 -0.0766252193650088 0.497157021376042 mirMAP -0.618249937266254 0.023648343539954 hsa-miR-19b-3p FZD3 -0.0232406250000019 0.402772271458001 -0.0766252193650088 0.497157021376042 mirMAP -1.04172671165004 0.000363540601148542 hsa-miR-211-5p FZD3 0.0854125000000003 0.0115410145748453 -0.0766252193650088 0.497157021376042 mirMAP -0.489321650074202 0.0413994321769136 hsa-miR-30a-3p FZD3 0.0310927083333314 0.212235313484241 -0.0766252193650088 0.497157021376042 mirMAP -0.655125793922743 0.0471457302509103 hsa-miR-30e-3p FZD3 -0.0753822916666668 0.0158956125513102 -0.0766252193650088 0.497157021376042 mirMAP -0.573384003135279 0.0273358579417933 hsa-miR-182-5p SFRP1 0.137020833333333 0.00166040840475327 -0.918311685823821 4.23744371853458e-08 mirMAP -1.22522542460347 1.1803349816974e-05 hsa-miR-96-5p SFRP1 0.249976041666667 0.00238507891968062 -0.918311685823821 4.23744371853458e-08 mirMAP -0.909196461385594 2.53104434183187e-10 hsa-miR-302b-5p SFRP4 0.00882187500000198 0.783437726190452 0.723042010172955 0.0177187855512114 mirMAP -1.66420425794662 0.016382394113096 hsa-miR-130b-3p MAPK8 0.187960416666667 4.08884220213037e-05 -0.171765768887781 0.0118048295600565 mirMAP -0.398294745359554 0.000133616203127718 hsa-miR-301a-3p MAPK8 0.3210625 1.40398117330319e-08 -0.171765768887781 0.0118048295600565 mirMAP -0.483212681798208 1.84481120119017e-09 hsa-miR-30d-5p MAPK8 0.0889593749999984 0.00165769192018322 -0.171765768887781 0.0118048295600565 mirMAP -0.473905073649726 0.00625287502540878 hsa-miR-30a-3p MAPK10 0.0310927083333314 0.212235313484241 -0.403891331278732 8.38548943358056e-08 mirMAP -0.55406522206186 0.014909865043787 hsa-miR-135a-5p CCND1 0.259042708333334 0.0155428289085859 -0.489663700767601 0.00116327564880174 mirMAP -0.326847391306503 0.00122534295974651 hsa-miR-182-3p CCND1 0.0753947916666695 0.035874933575007 -0.489663700767601 0.00116327564880174 mirMAP -1.51135906535771 3.89211108855043e-07 hsa-miR-186-5p CCND1 0.119613541666665 4.08271418900568e-07 -0.489663700767601 0.00116327564880174 mirMAP -1.1311649091679 0.013231462044433 23204228 Cyclin D1 CCND1 cyclin-dependent kinase CDK2 and CDK6 were each directly targeted for inhibition by miR-186 and restoring their expression reversed miR-186-mediated inhibition of cell-cycle progression progression; lung cancer hsa-miR-330-3p CCND1 0.0475489583333344 0.000859543426581515 -0.489663700767601 0.00116327564880174 mirMAP -4.04112331060711 1.736139401746e-07 hsa-miR-148a-3p PPARD -0.0141499999999994 0.738059428971636 0.118552935962505 0.0143804727683645 mirMAP -0.241461783543425 0.00332222912994318 hsa-miR-449a PPARD 0.0338000000000005 0.112855788380633 0.118552935962505 0.0143804727683645 mirMAP -0.328106337574425 0.0486313687077288 hsa-miR-34b-5p CCND3 0.106034375000001 0.00022824345015252 -0.193453444123804 0.0107139093322308 mirMAP -0.461587986258149 0.0145519109577952 hsa-miR-302b-3p CSNK1A1 -0.0521843749999984 0.249006520516215 -0.138624470628192 0.0227394315885017 mirMAP -0.194343456372839 0.045465321940232 hsa-miR-9-3p CSNK1A1 0.169132291666668 0.0035773401279874 -0.138624470628192 0.0227394315885017 mirMAP -0.186391148682084 0.0125870913589213 hsa-miR-26a-5p WNT5A -0.0802614583333372 6.57714639384254e-05 0.662661385024294 0.000934844185938212 mirMAP;miRNATAP -2.1755486418937 0.00265224790089392 hsa-miR-151a-3p CCND2 0.1604625 5.93234549735351e-08 -0.0166722150535952 0.799625753551218 mirMAP -0.32647463064626 0.0346821529919205 hsa-miR-124-3p RAC2 0.0765510416666685 0.0406801811765009 -0.58880100295462 2.16824201752923e-05 mirMAP -0.667959458315487 0.0142272045151047 hsa-miR-142-5p APC -0.118083333333333 0.00782838989880578 0.0471771018660387 0.429776421832463 mirMAP -0.196409423952767 0.0405921065114126 hsa-miR-373-5p MAP3K7 -0.119583333333332 0.00146942333136967 0.197672808642468 0.0112927777039728 mirMAP -0.710040668113096 1.03117784709829e-06 hsa-miR-374a-5p MYC 0.0364093749999981 0.144216889364782 -0.477164636319847 0.0167562282914519 mirMAP -1.48191687179477 0.0113708766110796 hsa-miR-30b-5p PRICKLE1 0.0675958333333311 0.0250792126411936 -0.857244431292353 8.05438071206138e-08 mirMAP -1.5011511138518 0.000124443279726163 hsa-miR-330-3p PRICKLE1 0.0475489583333344 0.000859543426581515 -0.857244431292353 8.05438071206138e-08 mirMAP;miRNATAP -5.85994907908097 5.6826527706478e-13 hsa-miR-142-5p SMAD4 -0.118083333333333 0.00782838989880578 -0.0193483612021588 0.537991502197394 mirMAP -0.182499481759745 0.000196448494633084 24895601 We identified three significantly associated mRNA-miRNA pairs: BCL2 was positively associated with miR-16 and SMAD4 was positively associated with miR-567 in the CRC tissue while MSH6 was positively associated with miR-142-5p in the normal tissue colorectal cancer hsa-miR-150-5p SMAD4 -0.176727083333334 0.000745566468765205 -0.0193483612021588 0.537991502197394 mirMAP -0.160668768261002 9.50641527771605e-05 hsa-miR-154-3p SMAD4 -0.0302083333333325 0.698129908482012 -0.0193483612021588 0.537991502197394 mirMAP -0.0560608460029839 0.0489397326904954 hsa-miR-363-3p SMAD4 0.0402572916666674 0.285465416838525 -0.0193483612021588 0.537991502197394 mirMAP -0.138882298846328 0.0184533530969159 hsa-miR-323a-3p PRKACB -0.0647520833333322 0.423729214327369 -0.138667096100081 0.140617869700975 mirMAP -0.226156347184884 0.00669105223485676 hsa-miR-148b-3p WNT9A 0.138957291666665 6.22558400405251e-09 -0.589303230232116 5.86011641157039e-05 mirMAP -2.55304135257887 1.18892260985373e-09 hsa-miR-15a-5p WNT9A 0.0147270833333326 0.571410997712819 -0.589303230232116 5.86011641157039e-05 mirMAP -1.34080276562968 0.00127315161489435 hsa-miR-15b-5p WNT9A 0.169857291666666 1.47790035184518e-07 -0.589303230232116 5.86011641157039e-05 mirMAP -1.48977140140439 2.57058556738865e-06 hsa-miR-16-5p WNT9A 0.0473343749999984 0.0231299407954158 -0.589303230232116 5.86011641157039e-05 mirMAP -1.35692921854425 0.00947251202195249 hsa-miR-193a-3p WNT9A 0.0943291666666665 0.0034681283330623 -0.589303230232116 5.86011641157039e-05 mirMAP -1.18426916619942 0.000320407292795022 hsa-miR-28-5p WNT9A 0.00902187499999979 0.573961937625452 -0.589303230232116 5.86011641157039e-05 mirMAP -1.70866478635053 0.0140269139729404 hsa-miR-32-5p WNT9A 0.158658333333333 1.2763158295478e-06 -0.589303230232116 5.86011641157039e-05 mirMAP -1.83051265435876 3.13687092977939e-09 hsa-miR-330-3p WNT9A 0.0475489583333344 0.000859543426581515 -0.589303230232116 5.86011641157039e-05 mirMAP -3.49388121436934 4.79155139628654e-06 hsa-miR-331-3p WNT9A 0.142898958333333 1.85230841027855e-08 -0.589303230232116 5.86011641157039e-05 mirMAP -2.11798698867328 1.20131144568017e-07 hsa-miR-96-5p WNT9A 0.249976041666667 0.00238507891968062 -0.589303230232116 5.86011641157039e-05 mirMAP -0.2553064433984 0.0486417798336747 hsa-miR-186-5p CAMK2D 0.119613541666665 4.08271418900568e-07 -0.200760394239715 0.00604513510738709 mirMAP -0.452608333752838 0.0401109747348107 hsa-miR-182-5p DAAM2 0.137020833333333 0.00166040840475327 -0.180255861829957 0.0353055854211658 mirMAP -0.412657912958129 0.00318575440175775 hsa-miR-9-5p DAAM2 0.206358333333334 0.00474844163137852 -0.180255861829957 0.0353055854211658 mirMAP -0.314081117554928 0.000146704685060002 hsa-miR-142-5p PRKCA -0.118083333333333 0.00782838989880578 0.185818287677706 0.0154752151667042 mirMAP -0.250931617402804 0.0436209566212719 hsa-miR-150-5p PRKCA -0.176727083333334 0.000745566468765205 0.185818287677706 0.0154752151667042 mirMAP -0.394596548800912 0.000131689125793864 hsa-miR-181a-5p PRKCA -0.0178312500000008 0.504202611435176 0.185818287677706 0.0154752151667042 mirMAP -0.481920128350103 0.0218353231354006 hsa-miR-181c-5p PRKCA -0.0391416666666661 0.24873704977008 0.185818287677706 0.0154752151667042 mirMAP -0.347972186035124 0.0343319440290331 hsa-miR-214-3p PRKCA -0.3224875 1.46111391717269e-10 0.185818287677706 0.0154752151667042 mirMAP -0.350856670248261 0.000740011670969227 hsa-miR-218-5p PRKCA -0.138427083333333 0.00268394855424833 0.185818287677706 0.0154752151667042 mirMAP -0.434291050708546 0.000230823322935252 hsa-miR-299-3p PRKCA -0.0750937499999992 0.133916719346714 0.185818287677706 0.0154752151667042 mirMAP -0.49187917448176 5.72581092880138e-06 hsa-miR-186-5p FZD7 0.119613541666665 4.08271418900568e-07 -0.288843854014127 0.0509167632008534 mirMAP -2.20885624678808 3.33032621111899e-07 hsa-miR-330-3p FZD7 0.0475489583333344 0.000859543426581515 -0.288843854014127 0.0509167632008534 mirMAP -2.84065634733799 0.000206968531533339 hsa-miR-373-5p FZD7 -0.119583333333332 0.00146942333136967 -0.288843854014127 0.0509167632008534 mirMAP -0.853157678303952 0.00236433973207396 hsa-miR-186-5p FZD1 0.119613541666665 4.08271418900568e-07 -0.709587354482393 8.54998654653992e-08 mirMAP -1.91309279923255 1.93064904900759e-06 hsa-miR-29a-3p FZD1 -0.0221583333333339 0.423651769453959 -0.709587354482393 8.54998654653992e-08 mirMAP -0.829144913500113 0.0214672489614919 hsa-miR-29b-3p FZD1 0.0261354166666654 0.47093801212574 -0.709587354482393 8.54998654653992e-08 mirMAP -0.730029722170837 0.00757085187604164 hsa-miR-148a-3p CTBP1 -0.0141499999999994 0.738059428971636 0.122510686475399 0.000376060446124626 mirMAP -0.305420337431805 8.36171884516658e-08 hsa-miR-365a-3p CTBP1 0.102759374999998 0.000922838847550007 0.122510686475399 0.000376060446124626 mirMAP -0.189112223305551 0.017157007790371 hsa-miR-449a CTBP1 0.0338000000000005 0.112855788380633 0.122510686475399 0.000376060446124626 mirMAP -0.30964895450194 0.00862931151493432 hsa-miR-143-3p DVL3 -0.0935458333333352 0.00823730512879721 0.114446993590549 0.000831052646869237 mirMAP -0.324501066322783 1.58380760323556e-06 hsa-miR-106b-5p VANGL2 0.171446874999999 6.25884640153194e-09 -0.356510038890634 0.113213829021286 mirMAP -1.60415949234582 0.00243245016737083 hsa-miR-186-5p VANGL2 0.119613541666665 4.08271418900568e-07 -0.356510038890634 0.113213829021286 mirMAP -3.4526728330879 1.43017653225421e-07 hsa-miR-196a-5p VANGL2 0.0730552083333349 0.0112355029700135 -0.356510038890634 0.113213829021286 mirMAP -1.83726596495008 0.00104877311414688 hsa-miR-30a-5p VANGL2 -0.103986458333335 0.00104622131231771 -0.356510038890634 0.113213829021286 mirMAP -1.37535884475569 0.00673506954957158 hsa-miR-30b-5p VANGL2 0.0675958333333311 0.0250792126411936 -0.356510038890634 0.113213829021286 mirMAP -3.41700064576739 2.75511181682154e-11 hsa-miR-30c-5p VANGL2 -0.0468291666666689 0.0597963082931316 -0.356510038890634 0.113213829021286 mirMAP -2.73449928672247 2.47889114809563e-05 hsa-miR-30d-5p VANGL2 0.0889593749999984 0.00165769192018322 -0.356510038890634 0.113213829021286 mirMAP -2.02302346157221 0.000363483141316154 hsa-miR-30e-5p VANGL2 -0.0271500000000011 0.286699748910542 -0.356510038890634 0.113213829021286 mirMAP -3.15312335089562 5.27674420966439e-07 hsa-miR-126-5p FZD5 0.00174583333333045 0.93995162076006 0.156615075177879 0.0518533853849842 mirMAP -0.726116812022422 0.0042232267468373 hsa-miR-142-5p FZD5 -0.118083333333333 0.00782838989880578 0.156615075177879 0.0518533853849842 mirMAP -0.579628303932409 5.38286715463966e-06 hsa-miR-30e-3p FZD5 -0.0753822916666668 0.0158956125513102 0.156615075177879 0.0518533853849842 mirMAP -0.420743492012162 0.023625705534674 hsa-miR-197-3p PRICKLE2 0.0443749999999999 0.00744353941884904 -0.710410295531476 1.70850958175018e-05 mirMAP -2.6215620685323 0.00043702315703843 hsa-miR-216a-5p PRICKLE2 0.166075000000001 0.000626168179963556 -0.710410295531476 1.70850958175018e-05 mirMAP -0.976012164359699 6.32080728015809e-05 hsa-miR-342-3p BTRC 0.0121989583333333 0.814558160538235 0.115058906471312 0.0399921555489253 mirMAP -0.160977965121847 0.0382177796060154 hsa-miR-373-5p BTRC -0.119583333333332 0.00146942333136967 0.115058906471312 0.0399921555489253 mirMAP -0.30086478180968 0.00448647602303325 hsa-miR-302b-3p SMAD3 -0.0521843749999984 0.249006520516215 0.252092893656572 0.00235787885298325 mirMAP -0.310153988103561 0.0198242101200759 hsa-miR-373-5p SMAD3 -0.119583333333332 0.00146942333136967 0.252092893656572 0.00235787885298325 mirMAP -0.32228295494946 0.0427853394729983 hsa-miR-21-5p CXXC4 0.231863541666666 0.000179777588577221 0.00742687751666082 0.971146080408158 mirMAP -0.506426476872282 0.0309523341989661 hsa-miR-126-5p VANGL1 0.00174583333333045 0.93995162076006 0.114511596030802 0.21590508129194 mirMAP -0.699570684607222 0.0165359947417587 hsa-miR-195-5p VANGL1 -0.182735416666667 8.68760983755402e-06 0.114511596030802 0.21590508129194 mirMAP -0.409564498533032 0.00965500217963581 hsa-miR-218-5p VANGL1 -0.138427083333333 0.00268394855424833 0.114511596030802 0.21590508129194 mirMAP -0.283085341912389 0.0482729047611534 hsa-miR-22-3p VANGL1 -0.076525 0.0267118796232183 0.114511596030802 0.21590508129194 mirMAP -0.486992442274239 0.0113941983283082 hsa-miR-376a-3p VANGL1 -0.071173958333333 0.24451007780002 0.114511596030802 0.21590508129194 mirMAP -0.245865812202912 0.0237998195242525 hsa-miR-214-3p VANGL1 -0.3224875 1.46111391717269e-10 0.114511596030802 0.21590508129194 mirMAP -0.34093675332614 0.00657247267448294 hsa-miR-154-3p FZD4 -0.0302083333333325 0.698129908482012 0.0472296826427225 0.558273177603475 mirMAP -0.33124717939183 5.42451593789104e-06 hsa-miR-200b-3p FZD4 -0.525884375 1.04581265194109e-09 0.0472296826427225 0.558273177603475 mirMAP -0.133692745961616 0.0370812251386658 hsa-miR-429 FZD4 -0.0799427083333338 0.00239378361551957 0.0472296826427225 0.558273177603475 mirMAP -0.468448865750551 0.03339031928463 hsa-miR-92a-3p FZD4 -0.0250031250000018 0.378880808632843 0.0472296826427225 0.558273177603475 mirMAP -0.665646395886408 0.00111950423112854 hsa-miR-101-3p SMAD2 -0.128581250000001 3.94323443134545e-05 0.233004999272719 0.0002706418147499 mirMAP -0.826218822694226 5.36915813355556e-09 hsa-miR-144-3p SMAD2 -0.112929166666666 0.0224448327150592 0.233004999272719 0.0002706418147499 mirMAP -0.292454604523909 0.00170886839738447 hsa-miR-146a-5p SMAD2 -0.148920833333335 0.000192527035623475 0.233004999272719 0.0002706418147499 mirMAP -0.306520219215399 0.00760549259391096 hsa-miR-26a-5p SMAD2 -0.0802614583333372 6.57714639384254e-05 0.233004999272719 0.0002706418147499 mirMAP -0.60355252694361 0.00917289273977687 hsa-miR-26b-5p SMAD2 -0.0469791666666701 0.0492766500438207 0.233004999272719 0.0002706418147499 mirMAP -0.875695416205914 5.84751379126145e-06 hsa-miR-30a-3p SMAD2 0.0310927083333314 0.212235313484241 0.233004999272719 0.0002706418147499 mirMAP -0.765193583084879 4.05442137330998e-05 hsa-miR-30c-5p SMAD2 -0.0468291666666689 0.0597963082931316 0.233004999272719 0.0002706418147499 mirMAP -1.02325132781683 2.19173178261017e-08 hsa-miR-30e-3p SMAD2 -0.0753822916666668 0.0158956125513102 0.233004999272719 0.0002706418147499 mirMAP -0.966603487399957 8.24353350788928e-12 hsa-miR-30e-5p SMAD2 -0.0271500000000011 0.286699748910542 0.233004999272719 0.0002706418147499 mirMAP -0.672649245835294 0.000239506776625534 hsa-miR-373-5p SMAD2 -0.119583333333332 0.00146942333136967 0.233004999272719 0.0002706418147499 mirMAP -0.64492849752131 6.30541719392184e-08 hsa-miR-192-5p SMAD2 0.0112031249999982 0.726219431607783 0.233004999272719 0.0002706418147499 mirMAP -0.538855245458106 0.000206065125237745 hsa-miR-302b-5p TBL1XR1 0.00882187500000198 0.783437726190452 0.190962309927984 0.0376557917240184 mirMAP -0.633273800288101 0.00223237965619878 hsa-miR-30e-3p TBL1XR1 -0.0753822916666668 0.0158956125513102 0.190962309927984 0.0376557917240184 mirMAP -0.753594027869546 0.000337132101579523 hsa-miR-373-5p PLCB1 -0.119583333333332 0.00146942333136967 0.803184556911579 2.54367115402579e-06 mirMAP -2.03357322828168 1.6915809198534e-10 hsa-miR-29c-3p PRKX -0.119800000000001 0.0103503840465436 0.0295582203370106 0.735259443898609 mirMAP -0.382881094764156 0.00398802336678297 hsa-miR-149-5p WNT7B -0.0142947916666665 0.594117902122907 -0.0233939293061791 0.550966964308638 mirMAP -0.36396772928947 0.000473136515772679 hsa-miR-448 WNT4 0.029692708333334 0.16644209566908 -0.536523080512791 0.000660223576486418 miRNATAP -1.63922122104265 0.00251343181052766 hsa-miR-448 FZD7 0.029692708333334 0.16644209566908 -0.288843854014127 0.0509167632008534 miRNATAP -2.56430169970003 1.94227382027336e-07 hsa-miR-448 PPARD 0.029692708333334 0.16644209566908 0.118552935962505 0.0143804727683645 miRNATAP -0.402368751410002 0.0147142891242987 hsa-miR-448 NFATC2 0.029692708333334 0.16644209566908 -0.211033921703619 0.0515244993059601 miRNATAP -1.70986285939049 2.45447561213488e-06 hsa-miR-448 DKK2 0.029692708333334 0.16644209566908 0.289580160909749 0.0557020653186319 miRNATAP -1.91919845396054 0.000180484763426214 hsa-miR-23a-3p FRAT2 -0.0224822916666669 0.180920975137738 0.0314279064539722 0.708449567334936 miRNATAP -0.961506772678844 0.00929379571538904 hsa-miR-23a-3p CSNK2A2 -0.0224822916666669 0.180920975137738 0.06215601757496 0.293610338719952 miRNATAP -0.662142750901822 0.0108586302125329 hsa-miR-23a-3p FZD5 -0.0224822916666669 0.180920975137738 0.156615075177879 0.0518533853849842 miRNATAP -1.27164858969388 0.000315288158209578 25422915 MiR-23a and/or miR-24 overexpression leads to gene silencing of FZD5 TMEM92 and/or HNF1B pancreatic cancer hsa-miR-375 WNT5A -0.553344791666666 8.52426333986314e-09 0.662661385024294 0.000934844185938212 miRNATAP -0.551419881924647 0.000126195686264926 hsa-miR-375 NLK -0.553344791666666 8.52426333986314e-09 0.17841787778347 0.00756701122609011 miRNATAP -0.153676760372486 0.00131284212438342 hsa-miR-302c-5p CREBBP 0.0869791666666674 0.0136966249723328 -0.0398713366728938 0.332668797640848 miRNATAP -0.225195684985011 0.00642353992103358 hsa-miR-330-3p WNT11 0.0475489583333344 0.000859543426581515 -0.844710998421271 3.67211916338716e-05 miRNATAP -3.85031888530953 0.000360260076086216 hsa-miR-32-5p JUN 0.158658333333333 1.2763158295478e-06 -0.501788712602393 4.9924247594369e-05 miRNATAP -0.788516603226027 0.00346879126815154 hsa-let-7b-5p NLK -0.118293750000001 0.000772100831422107 0.17841787778347 0.00756701122609011 miRNATAP -0.291536858036273 0.0323794703408559 hsa-let-7b-5p MAPK9 -0.118293750000001 0.000772100831422107 0.11555201208399 0.0380112767490297 miRNATAP -0.284471901369996 0.0115820840311504 hsa-miR-30a-5p PPP3CB -0.103986458333335 0.00104622131231771 0.204701290405443 0.00444522807319962 miRNATAP -0.600887812858032 0.000198619306187871 hsa-miR-30a-3p CSNK1E 0.0310927083333314 0.212235313484241 0.278817302483912 0.00101487072640408 miRNATAP -0.978711673265544 7.59312095321505e-05 hsa-miR-106b-5p PPP3CA 0.171446874999999 6.25884640153194e-09 -0.163058424706868 0.00164514523193859 miRNATAP -0.54541848371446 5.76810807934442e-06 hsa-miR-106b-5p FZD7 0.171446874999999 6.25884640153194e-09 -0.288843854014127 0.0509167632008534 miRNATAP -0.821357585070741 0.0189131834448811 hsa-miR-106a-5p PPP3CA 0.0520072916666667 0.124210545689816 -0.163058424706868 0.00164514523193859 miRNATAP -0.295209089881245 0.00778555032502832 hsa-miR-106a-5p CCND2 0.0520072916666667 0.124210545689816 -0.0166722150535952 0.799625753551218 miRNATAP -0.38520318676018 0.00563506552679278 hsa-miR-23b-3p CSNK2A2 0.00990312499999879 0.577638557352371 0.06215601757496 0.293610338719952 miRNATAP -0.670988878258269 0.00613056880140691 hsa-miR-23b-3p FRAT2 0.00990312499999879 0.577638557352371 0.0314279064539722 0.708449567334936 miRNATAP -0.82084071281882 0.0187371831427244 hsa-miR-23b-3p FZD5 0.00990312499999879 0.577638557352371 0.156615075177879 0.0518533853849842 miRNATAP -1.06185714873191 0.00148462611858519 hsa-miR-126-5p AXIN1 0.00174583333333045 0.93995162076006 0.189152261779095 0.00643398296171833 miRNATAP -0.445405644167023 0.0435949600102593 hsa-miR-9-3p TCF7L2 0.169132291666668 0.0035773401279874 -0.12476485755165 0.075666606325994 miRNATAP -0.197648866105193 0.021862291957962 hsa-miR-144-3p WIF1 -0.112929166666666 0.0224448327150592 0.363650077730341 0.0145591465276953 miRNATAP -0.543757328610251 0.0121155151930557 hsa-miR-218-5p PPP2R5D -0.138427083333333 0.00268394855424833 0.357614172953129 1.46589895140722e-09 miRNATAP -0.322243242370696 0.000653886181968532 hsa-miR-135a-5p SIAH1 0.259042708333334 0.0155428289085859 -0.219570225447566 0.0197162099016641 miRNATAP -0.252400560656854 4.87887486489474e-05 hsa-miR-93-5p CCND2 0.188120833333332 2.87978994240045e-10 -0.0166722150535952 0.799625753551218 miRNATAP -0.410819537002923 0.00641777334198088 22180714 The miRNA microarray results were further validated with quantitative RT-PCR miR-93 was downregulated and its predicted mRNA targets included BAMBI CCND2 CDKN1A HDAC8 KIF23 MAP3K9 MAP3K11 MYCN PPARD TLE4 and ZDHHC1 colorectal cancer hsa-miR-93-5p PPP3CA 0.188120833333332 2.87978994240045e-10 -0.163058424706868 0.00164514523193859 miRNATAP -0.5251549559444 8.7996302281806e-06 hsa-miR-367-3p FZD10 0.0829458333333344 0.000944507545783653 0.213117453805136 0.0336419349181034 miRNATAP -1.14244482293009 5.99637742161154e-05 hsa-miR-200a-3p MAP3K7 -0.478053125 5.4010344994489e-09 0.197672808642468 0.0112927777039728 miRNATAP -0.129578398671622 0.0497719247857466 hsa-miR-155-5p FZD5 0.0446697916666664 0.147941447721798 0.156615075177879 0.0518533853849842 miRNATAP -0.629973483761312 0.000789994078255986 hsa-miR-18a-5p PRKACB 0.195905208333333 7.199331158466e-05 -0.138667096100081 0.140617869700975 miRNATAP -0.398559833092781 0.00298147000440335 hsa-miR-29b-3p LRP6 0.0261354166666654 0.47093801212574 -0.149405434713309 0.015290121892894 miRNATAP -0.365584189098946 0.00286384680604166 hsa-miR-29b-3p FRAT2 0.0261354166666654 0.47093801212574 0.0314279064539722 0.708449567334936 miRNATAP -0.609057247439361 0.000231638923469864 hsa-miR-148a-3p EP300 -0.0141499999999994 0.738059428971636 0.106443973458177 0.0571948587983776 miRNATAP -0.401100599249843 1.88181707096324e-05 hsa-miR-124-3p SFRP5 0.0765510416666685 0.0406801811765009 -1.96217629356525 3.98680310767494e-12 miRNATAP -1.27040552056808 0.0281667087161428 hsa-miR-222-3p AXIN2 0.154138541666667 3.31108124679705e-05 0.000123812425103065 0.997690310539718 miRNATAP -0.232555603739266 0.00374897958768707 hsa-miR-222-3p MAPK10 0.154138541666667 3.31108124679705e-05 -0.403891331278732 8.38548943358056e-08 miRNATAP -0.59408544946237 4.91941083260339e-05 hsa-miR-221-3p MAPK10 0.194085416666666 3.35284955391749e-06 -0.403891331278732 8.38548943358056e-08 miRNATAP -0.656397515137983 2.66748850250715e-07 hsa-miR-212-3p PPP2R5C 0.0388781249999999 0.0317156285118969 -0.150909959174399 0.0114911146917879 miRNATAP -0.509029460457276 0.0367380624287319 hsa-miR-452-5p CXXC4 0.0885708333333341 0.000606518257781443 0.00742687751666082 0.971146080408158 miRNATAP -1.29390572017029 0.0233015367171216 hsa-miR-150-5p FRAT2 -0.176727083333334 0.000745566468765205 0.0314279064539722 0.708449567334936 miRNATAP -0.32377026391727 0.00423052524341821 hsa-miR-150-5p GSK3B -0.176727083333334 0.000745566468765205 0.103984137985218 0.0904143607181575 miRNATAP -0.280467385890846 0.000667058711156781 hsa-miR-150-5p FZD4 -0.176727083333334 0.000745566468765205 0.0472296826427225 0.558273177603475 miRNATAP -0.26606074022865 0.0146247555862704 hsa-miR-150-5p PPP2CB -0.176727083333334 0.000745566468765205 -0.03790965447081 0.24492446926387 miRNATAP -0.13662896356929 0.00153803289650263 hsa-miR-105-5p VANGL2 0.172322916666667 0.00159136123673933 -0.356510038890634 0.113213829021286 miRNATAP -1.19046019640089 4.00982062182778e-05 hsa-miR-105-5p FZD7 0.172322916666667 0.00159136123673933 -0.288843854014127 0.0509167632008534 miRNATAP -0.598421258079507 0.00188649401808791 hsa-miR-26a-5p NLK -0.0802614583333372 6.57714639384254e-05 0.17841787778347 0.00756701122609011 miRNATAP -0.897814069417852 0.000158713339849998 hsa-miR-26a-5p PLCB1 -0.0802614583333372 6.57714639384254e-05 0.803184556911579 2.54367115402579e-06 miRNATAP -3.03019054989985 7.89056509848666e-07 hsa-miR-26a-5p LEF1 -0.0802614583333372 6.57714639384254e-05 0.200563151628987 1.75899802161241e-05 miRNATAP -0.607043590189195 0.000306301425401212 hsa-miR-26a-5p FRAT2 -0.0802614583333372 6.57714639384254e-05 0.0314279064539722 0.708449567334936 miRNATAP -0.681704460224324 0.0232494244171357 hsa-miR-137 MAPK10 0.0312114583333318 0.288380289785221 -0.403891331278732 8.38548943358056e-08 miRNATAP -0.395820347859423 0.0398984774119641 hsa-miR-183-5p LRP6 0.20613125 6.32481790369784e-05 -0.149405434713309 0.015290121892894 miRNATAP -0.206420855315718 0.0146277845736954 hsa-miR-183-5p CCND2 0.20613125 6.32481790369784e-05 -0.0166722150535952 0.799625753551218 miRNATAP -0.227757989612634 0.0109020560079636 hsa-miR-214-3p GSK3B -0.3224875 1.46111391717269e-10 0.103984137985218 0.0904143607181575 miRNATAP -0.274270485816832 0.000918622206325122 hsa-miR-21-5p PPP3CA 0.231863541666666 0.000179777588577221 -0.163058424706868 0.00164514523193859 miRNATAP -0.196732737107536 0.00086411653055345 hsa-miR-197-3p CAMK2D 0.0443749999999999 0.00744353941884904 -0.200760394239715 0.00604513510738709 miRNATAP -0.707252127140608 0.0308719405251689 hsa-miR-30d-5p PPP3CA 0.0889593749999984 0.00165769192018322 -0.163058424706868 0.00164514523193859 miRNATAP -0.300955761287835 0.0228146694179137 hsa-miR-30d-5p PRICKLE1 0.0889593749999984 0.00165769192018322 -0.857244431292353 8.05438071206138e-08 miRNATAP -1.68514167424324 4.76693532557472e-05 hsa-miR-17-5p PPP3CA 0.0594531249999994 0.0577784446787179 -0.163058424706868 0.00164514523193859 miRNATAP -0.31610736679818 0.00830030311253676 hsa-miR-202-3p MAPK9 -0.187226041666666 1.15049557220475e-06 0.11555201208399 0.0380112767490297 miRNATAP -0.280264454798402 0.00554512387935798 hsa-miR-19a-3p DAAM1 0.0212885416666653 0.477294105669598 -0.09736079888477 0.257360845225757 miRNATAP -0.824528612490385 5.8175575802855e-05 hsa-miR-19a-3p MAPK10 0.0212885416666653 0.477294105669598 -0.403891331278732 8.38548943358056e-08 miRNATAP -0.64519891747312 0.000569041560757039 hsa-miR-19b-3p DAAM1 -0.0232406250000019 0.402772271458001 -0.09736079888477 0.257360845225757 miRNATAP -0.468145683804168 0.0374539825095884 hsa-miR-19b-3p MAPK10 -0.0232406250000019 0.402772271458001 -0.403891331278732 8.38548943358056e-08 miRNATAP -0.456633091260184 0.0252371165085704 hsa-miR-26b-5p PLCB1 -0.0469791666666701 0.0492766500438207 0.803184556911579 2.54367115402579e-06 miRNATAP -3.46456798834309 7.85200377786736e-12 hsa-miR-26b-5p FRAT2 -0.0469791666666701 0.0492766500438207 0.0314279064539722 0.708449567334936 miRNATAP -0.536271964131844 0.0357318471790979 hsa-miR-378a-5p NFATC2 -0.185940625 9.58922808820003e-06 -0.211033921703619 0.0515244993059601 miRNATAP -0.43501409409955 0.0169556057985746 hsa-miR-20a-5p FZD4 -0.0185229166666687 0.563457138702111 0.0472296826427225 0.558273177603475 miRNATAP -0.490927383542411 0.00681501281708153 hsa-miR-301a-3p MAPK10 0.3210625 1.40398117330319e-08 -0.403891331278732 8.38548943358056e-08 miRNATAP -0.501833233048804 5.36857601829661e-08 hsa-miR-429 PLCB1 -0.0799427083333338 0.00239378361551957 0.803184556911579 2.54367115402579e-06 miRNATAP -1.19565535956551 0.012629436755002 hsa-miR-429 WNT2B -0.0799427083333338 0.00239378361551957 0.0877035000244186 0.209989232432612 miRNATAP -0.501858712316549 0.00841165211344969 hsa-miR-429 CTNNBIP1 -0.0799427083333338 0.00239378361551957 0.00197407904286706 0.959835743307648 miRNATAP -0.215659669934932 0.0416647511091857 hsa-miR-429 DVL3 -0.0799427083333338 0.00239378361551957 0.114446993590549 0.000831052646869237 miRNATAP -0.194851645947302 0.0370784364921706 hsa-miR-15b-5p LRP6 0.169857291666666 1.47790035184518e-07 -0.149405434713309 0.015290121892894 miRNATAP -0.491902472266434 0.000197207350826496 hsa-miR-15b-5p PPP2R5C 0.169857291666666 1.47790035184518e-07 -0.150909959174399 0.0114911146917879 miRNATAP -0.470435675569712 0.000242757972954863 hsa-miR-15b-5p SIAH1 0.169857291666666 1.47790035184518e-07 -0.219570225447566 0.0197162099016641 miRNATAP -0.737564548002971 0.000273574997784205 hsa-miR-15b-5p FOSL1 0.169857291666666 1.47790035184518e-07 -0.543265687537282 0.00108910764212718 miRNATAP -1.68568921749195 2.29735932490187e-06 hsa-miR-29c-3p NFATC4 -0.119800000000001 0.0103503840465436 0.126331695415399 0.0640387076256883 miRNATAP -0.316649642998915 0.00230964940834435 hsa-miR-29c-3p FRAT2 -0.119800000000001 0.0103503840465436 0.0314279064539722 0.708449567334936 miRNATAP -0.46409356077112 0.000257679467164421 hsa-let-7f-5p VANGL2 -0.0293635416666693 0.45178215359693 -0.356510038890634 0.113213829021286 miRNATAP -1.00102927839261 0.0165428375023772 hsa-let-7d-5p VANGL2 -0.00841145833333479 0.75459096821833 -0.356510038890634 0.113213829021286 miRNATAP -1.38058313837917 0.0238385459302887 hsa-miR-206 CCND1 0.0323270833333327 0.132508035975732 -0.489663700767601 0.00116327564880174 miRNATAP -1.79914585493454 0.00048064191527603 hsa-miR-338-3p CAMK2A -0.120344791666666 0.00224547965794864 0.154859457150701 0.0544358635832875 miRNATAP -0.351109796635639 0.0162932026769953 hsa-miR-338-3p CAMK2G -0.120344791666666 0.00224547965794864 0.203579825180791 0.00105262020237704 miRNATAP -0.226154800436585 0.0470295958280603 hsa-miR-27a-3p PPP3R1 -0.00334791666666856 0.862458239652667 0.0189274812228692 0.752755399526254 miRNATAP -0.635202791428473 0.00520776768818762 hsa-miR-185-5p CAMK2D 0.114770833333333 3.04516894436275e-07 -0.200760394239715 0.00604513510738709 miRNATAP -0.487732492635447 0.035950347333421 hsa-miR-9-5p CSNK1A1 0.206358333333334 0.00474844163137852 -0.138624470628192 0.0227394315885017 miRNATAP -0.160460643339697 0.00674774931477838 hsa-miR-323a-3p FBXW11 -0.0647520833333322 0.423729214327369 0.103076252948277 0.0132185858141707 miRNATAP -0.109644361529703 0.00275473046255181 hsa-miR-182-5p DAAM1 0.137020833333333 0.00166040840475327 -0.09736079888477 0.257360845225757 miRNATAP -0.428183305954561 0.00218336994257662 hsa-miR-182-5p TCF7L2 0.137020833333333 0.00166040840475327 -0.12476485755165 0.075666606325994 miRNATAP -0.284762588943678 0.0131085486732099 hsa-miR-30c-5p WNT7B -0.0468291666666689 0.0597963082931316 -0.0233939293061791 0.550966964308638 miRNATAP -0.230335159814262 0.0419298832784329 hsa-miR-30c-5p PPP3CB -0.0468291666666689 0.0597963082931316 0.204701290405443 0.00444522807319962 miRNATAP -0.472956374445815 0.0254064861301929 hsa-miR-92a-3p DAAM1 -0.0250031250000018 0.378880808632843 -0.09736079888477 0.257360845225757 miRNATAP -0.524833554203848 0.0167484116361665 hsa-miR-29a-3p NFATC4 -0.0221583333333339 0.423651769453959 0.126331695415399 0.0640387076256883 miRNATAP -0.423403538679337 0.0180252915240446 hsa-miR-29a-3p FRAT2 -0.0221583333333339 0.423651769453959 0.0314279064539722 0.708449567334936 miRNATAP -0.671902837363298 0.00213891587894906 hsa-miR-15a-5p LRP6 0.0147270833333326 0.571410997712819 -0.149405434713309 0.015290121892894 miRNATAP -0.35190885059454 0.0420973643372408 hsa-miR-125b-5p DVL3 -0.187647916666668 1.01964050843717e-05 0.114446993590549 0.000831052646869237 miRNATAP -0.225989053780101 5.00951204688994e-05 hsa-miR-125b-5p PLCB1 -0.187647916666668 1.01964050843717e-05 0.803184556911579 2.54367115402579e-06 miRNATAP -2.59264864520394 8.32705225645816e-24 hsa-miR-424-5p PPP3CB -0.163364583333334 2.62229410811717e-07 0.204701290405443 0.00444522807319962 miRNATAP -0.558491063819421 0.000425830764261871 hsa-miR-194-5p PRICKLE2 0.0261989583333311 0.382675312355506 -0.710410295531476 1.70850958175018e-05 miRNATAP -1.05899091028316 0.00944584714595638 hsa-miR-320a PPP2R5B 0.0244749999999987 0.226230360993065 0.140697784708815 0.016178286052138 miRNATAP -0.51900057778483 0.0146543451095444 hsa-miR-130b-3p MAPK10 0.187960416666667 4.08884220213037e-05 -0.403891331278732 8.38548943358056e-08 miRNATAP -0.696889533173132 1.5420725936779e-09 hsa-miR-27b-3p VANGL2 -0.0034427083333346 0.862641943637602 -0.356510038890634 0.113213829021286 miRNATAP -3.31936642144864 5.5889582402893e-05 hsa-miR-27b-3p DVL2 -0.0034427083333346 0.862641943637602 0.392328080664631 8.7563438221752e-08 miRNATAP -0.926310845928656 0.000880647442843547 hsa-miR-16-5p LRP6 0.0473343749999984 0.0231299407954158 -0.149405434713309 0.015290121892894 miRNATAP -0.699690087363833 0.00111962452364689 hsa-miR-16-5p SIAH1 0.0473343749999984 0.0231299407954158 -0.219570225447566 0.0197162099016641 miRNATAP -0.697122069456677 0.0356169017500731