miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-148a-3p A4GNT -0.748702855596996 3.93313343865641e-07 -1.23788904255124 0.00041788399420954 MirTarget -0.727930454392835 1.19337356882915e-10 NA NA NA hsa-miR-20b-5p AADAC 0.457668023910379 0.0285865211936156 -1.53356480638852 1.2937396141924e-06 MirTarget -0.222276623052243 0.00290346100031377 NA NA NA hsa-miR-27b-3p AAGAB -0.823491817819754 9.20935302746823e-14 0.452586391901909 1.6681499731678e-13 MirTarget -0.1257366499343 2.69803797606813e-06 NA NA NA hsa-miR-455-3p AAK1 -1.3998033821095 5.72010709806871e-17 0.62162910644816 6.70592413003848e-11 PITA -0.20443700481848 1.06421902534658e-14 NA NA NA hsa-miR-146b-5p AASS 0.419719546795449 0.0457375823220155 -1.86276668073123 4.05613977215642e-10 miRanda -0.168641670519287 0.0170188255961773 NA NA NA hsa-miR-182-5p AASS 1.96601340710222 4.39326175603633e-09 -1.86276668073123 4.05613977215642e-10 MirTarget -0.239661617667643 2.13043406737926e-08 NA NA NA hsa-miR-21-5p ABAT 1.51084295924322 1.54551622173259e-34 -2.16281544019696 3.93403666966165e-18 MirTarget -0.92627033209199 4.24502265699131e-25 NA NA NA hsa-miR-21-5p ABCA1 1.51084295924322 1.54551622173259e-34 -1.09636606966708 7.96780532063531e-16 mirMAP -0.285550113313049 1.80466337738302e-08 NA NA NA hsa-miR-21-5p ABCA10 1.51084295924322 1.54551622173259e-34 -1.06365527432395 3.8402730713037e-05 mirMAP -0.450522220378371 1.73922913330204e-06 NA NA NA hsa-miR-455-5p ABCA4 -0.270546034117157 0.0581320703577731 0.728345598774567 0.00376140596862793 miRanda -0.215235688971405 0.0127714394062866 NA NA NA hsa-miR-181a-5p ABCA5 0.250113435902954 0.0551933249319293 -0.135688344893514 0.307906525890114 mirMAP -0.262639747438346 9.3956837371013e-08 NA NA NA hsa-miR-181b-5p ABCA5 0.488256489401108 0.00105321129419701 -0.135688344893514 0.307906525890114 mirMAP -0.263200077061798 6.19679810308192e-10 NA NA NA hsa-miR-29c-3p ABCC5 -1.4367517608807 1.61767774905781e-21 1.23282495059029 1.29865153692267e-30 mirMAP -0.2837534717216 1.14019728847642e-16 NA NA NA hsa-miR-409-3p ABCC9 -0.499649792570937 0.0526751181520117 -2.33484904605969 1.85004493132718e-16 mirMAP -0.191351362057662 0.00056256933752651 NA NA NA hsa-miR-21-5p ABCD3 1.51084295924322 1.54551622173259e-34 -0.902074727071182 3.19852861835435e-18 miRNAWalker2_validate -0.37544948577207 7.02368348393481e-24 NA NA NA hsa-miR-455-5p ABCE1 -0.270546034117157 0.0581320703577731 -0.365474664039608 3.76937535156026e-06 miRanda -0.104373068898686 0.000117843297286932 NA NA NA hsa-miR-224-3p ABCG2 1.40770116795301 1.31426607144612e-08 -1.7076806057577 2.07418898418233e-09 mirMAP -0.135110427663466 0.0177489557502928 NA NA NA hsa-miR-181b-5p ABHD13 0.488256489401108 0.00105321129419701 -0.675509398353543 1.01147666568484e-14 MirTarget -0.107355672286902 0.00024307849858895 NA NA NA hsa-miR-181b-5p ABHD15 0.488256489401108 0.00105321129419701 -1.30485636745916 1.43347474031291e-12 mirMAP -0.437228081342153 3.82119743580348e-13 NA NA NA hsa-miR-19b-3p ABHD2 0.601279551368824 0.00016685097085251 -1.20462139360653 3.09717296882448e-15 mirMAP -0.236264843739319 6.63709060446833e-07 NA NA NA hsa-miR-20a-5p ABHD2 0.854326758727003 5.04256669663285e-07 -1.20462139360653 3.09717296882448e-15 miRNATAP -0.280755866928053 1.59918873748929e-10 NA NA NA hsa-miR-20b-5p ABHD2 0.457668023910379 0.0285865211936156 -1.20462139360653 3.09717296882448e-15 miRNATAP -0.137281334005477 0.000180676081515189 NA NA NA hsa-miR-19b-3p ABHD5 0.601279551368824 0.00016685097085251 -0.597165516206204 1.07129426217362e-09 miRNAWalker2_validate -0.112081799455001 0.000201389629700295 NA NA NA hsa-miR-20a-5p ABHD5 0.854326758727003 5.04256669663285e-07 -0.597165516206204 1.07129426217362e-09 MirTarget -0.124155074971842 9.40698978083883e-06 NA NA NA hsa-miR-192-3p ABL2 -0.6401165114007 0.000266272092403814 0.604144141236531 5.10108537709865e-11 MirTarget -0.132455576431082 2.38671466579862e-07 NA NA NA hsa-miR-30e-5p ABL2 -0.627815042856657 3.02205690184908e-10 0.604144141236531 5.10108537709865e-11 mirMAP -0.182238354023163 5.40133886853721e-05 NA NA NA hsa-miR-34a-5p ABLIM3 1.03694231790865 5.74864019540594e-14 -1.27480272127387 3.6217012383643e-14 miRNATAP -0.155716360013707 0.00909720274124164 NA NA NA hsa-miR-455-5p ABLIM3 -0.270546034117157 0.0581320703577731 -1.27480272127387 3.6217012383643e-14 miRanda -0.142353574963733 0.0168275918573379 NA NA NA hsa-miR-30e-5p ABR -0.627815042856657 3.02205690184908e-10 -0.282817694608605 0.111870381994612 mirMAP -0.254419733653841 0.00304539909678276 NA NA NA hsa-miR-34a-5p ABR 1.03694231790865 5.74864019540594e-14 -0.282817694608605 0.111870381994612 miRNATAP -0.186153605772293 0.00227464144602648 NA NA NA hsa-miR-181a-5p ABTB2 0.250113435902954 0.0551933249319293 -0.433245274232974 0.00309618873065253 MirTarget;miRNATAP -0.307634495851197 1.47143177002636e-08 NA NA NA hsa-miR-181b-5p ABTB2 0.488256489401108 0.00105321129419701 -0.433245274232974 0.00309618873065253 MirTarget;miRNATAP -0.335782834467882 6.43366504390091e-13 NA NA NA hsa-miR-181a-5p ACAD8 0.250113435902954 0.0551933249319293 -0.524681533173251 9.68967331022413e-09 MirTarget -0.139325650333643 5.77059274088198e-05 NA NA NA hsa-miR-181b-5p ACAD8 0.488256489401108 0.00105321129419701 -0.524681533173251 9.68967331022413e-09 MirTarget -0.145164990680537 1.30987425524445e-06 NA NA NA hsa-miR-182-5p ACADSB 1.96601340710222 4.39326175603633e-09 -2.10604065735705 5.36295714659088e-25 mirMAP -0.258299760816515 3.08870803473294e-18 NA NA NA hsa-miR-224-3p ACADSB 1.40770116795301 1.31426607144612e-08 -2.10604065735705 5.36295714659088e-25 mirMAP -0.155338870323361 0.000238417098455365 NA NA NA hsa-miR-455-3p ACAN -1.3998033821095 5.72010709806871e-17 2.7233738320701 7.61686125061809e-13 MirTarget;miRNATAP -0.815226201166809 1.93745045523116e-14 NA NA NA hsa-miR-21-5p ACAT1 1.51084295924322 1.54551622173259e-34 -1.61982651854581 1.24371695502075e-23 miRNAWalker2_validate -0.618343622608645 6.65323276600699e-26 NA NA NA hsa-miR-19b-3p ACBD5 0.601279551368824 0.00016685097085251 -0.747355613421877 3.97123554106721e-11 MirTarget;miRNATAP -0.168326881893766 1.32451199793407e-06 NA NA NA hsa-miR-21-5p ACBD5 1.51084295924322 1.54551622173259e-34 -0.747355613421877 3.97123554106721e-11 miRNAWalker2_validate;miRNATAP -0.327371319483953 1.04628864477185e-15 NA NA NA hsa-miR-455-5p ACER2 -0.270546034117157 0.0581320703577731 -1.22071687076465 4.7957349673267e-08 miRanda -0.319200990194576 3.69391265293937e-05 NA NA NA hsa-miR-20a-5p ACER3 0.854326758727003 5.04256669663285e-07 0.019931089805842 0.84603738107892 mirMAP -0.123555370663773 1.73924053330843e-05 NA NA NA hsa-miR-30b-5p ACER3 -0.54056186708617 2.44688760798341e-05 0.019931089805842 0.84603738107892 miRNAWalker2_validate -0.133668805968959 0.000539367795958024 NA NA NA hsa-miR-148a-3p ACHE -0.748702855596996 3.93313343865641e-07 0.0664775463470139 0.84521711408755 miRNATAP -0.644498628240824 3.7505390632337e-09 NA NA NA hsa-miR-194-5p ACHE -0.292530160992458 0.0996141384876663 0.0664775463470139 0.84521711408755 MirTarget -0.379563659346616 4.407926862501e-05 NA NA NA hsa-miR-146b-5p ACO1 0.419719546795449 0.0457375823220155 -0.901613172142564 1.72939371106116e-12 miRanda -0.118656246747412 8.87843348016993e-05 NA NA NA hsa-miR-181a-5p ACOT12 0.250113435902954 0.0551933249319293 -2.27070132490093 1.82901371185644e-09 miRNAWalker2_validate -0.847262417727994 2.58102221249291e-09 NA NA NA hsa-miR-15a-5p ACOX1 0.349521211668244 0.000770735998804736 -1.15808823365487 5.04381483675569e-16 miRNATAP -0.296029207582436 1.93762698415884e-05 NA NA NA hsa-miR-20a-5p ACOX1 0.854326758727003 5.04256669663285e-07 -1.15808823365487 5.04381483675569e-16 mirMAP -0.146498998226335 0.000460144478820645 NA NA NA hsa-miR-20b-5p ACOX1 0.457668023910379 0.0285865211936156 -1.15808823365487 5.04381483675569e-16 mirMAP -0.165640850118116 1.22667906431298e-06 NA NA NA hsa-miR-192-5p ACPP -0.50188499512787 0.00344713341196035 -0.469596543578405 0.142691148120666 MirTarget -0.440640771483494 9.58060705830871e-07 NA NA NA hsa-miR-181a-5p ACSL1 0.250113435902954 0.0551933249319293 -2.33415071716027 1.71568734924942e-22 MirTarget -0.603299739561566 8.14631368219994e-11 NA NA NA hsa-miR-181b-5p ACSL1 0.488256489401108 0.00105321129419701 -2.33415071716027 1.71568734924942e-22 MirTarget -0.687895701481087 3.7949325394145e-18 NA NA NA hsa-miR-30c-5p ACSL3 -0.432111642767632 0.000159764714931007 0.0486045423342691 0.650439477521926 mirMAP -0.163063255723669 0.000324959613312219 NA NA NA hsa-miR-30e-5p ACSL3 -0.627815042856657 3.02205690184908e-10 0.0486045423342691 0.650439477521926 mirMAP -0.148167439395447 0.00409135262838913 NA NA NA hsa-miR-148a-3p ACSL4 -0.748702855596996 3.93313343865641e-07 2.07128895001209 1.06074462060898e-08 miRNATAP -0.646374144431349 5.43959417232703e-08 NA NA NA hsa-miR-181a-5p ACSL6 0.250113435902954 0.0551933249319293 0.391527588368073 0.264580316303862 miRNATAP -0.700546429668702 7.0293032449896e-08 NA NA NA hsa-miR-181b-5p ACSL6 0.488256489401108 0.00105321129419701 0.391527588368073 0.264580316303862 miRNATAP -0.746850334596502 2.61440384460246e-11 NA NA NA hsa-miR-20a-5p ACSL6 0.854326758727003 5.04256669663285e-07 0.391527588368073 0.264580316303862 mirMAP -0.211210152354206 0.033875040869321 NA NA NA hsa-miR-20b-5p ACSL6 0.457668023910379 0.0285865211936156 0.391527588368073 0.264580316303862 mirMAP -0.25735916708834 0.00160207620024541 NA NA NA hsa-miR-127-3p ACSM2A -1.0751374948053 2.19322892330221e-05 -2.2183339660143 2.74557581326559e-09 miRanda -0.142670213635525 0.0495232718836286 NA NA NA hsa-miR-192-3p ACSS1 -0.6401165114007 0.000266272092403814 0.291106962822674 0.182854176004533 mirMAP -0.354102849687618 2.39778794104008e-09 NA NA NA hsa-miR-34a-5p ACSS1 1.03694231790865 5.74864019540594e-14 0.291106962822674 0.182854176004533 miRNAWalker2_validate -0.229704085683972 0.00217265480905038 NA NA NA hsa-miR-181a-5p ACSS3 0.250113435902954 0.0551933249319293 -1.23440155322414 0.00018681401186901 MirTarget -0.95245123550659 3.32371957674369e-15 NA NA NA hsa-miR-181b-5p ACSS3 0.488256489401108 0.00105321129419701 -1.23440155322414 0.00018681401186901 MirTarget -1.00354902484031 2.36850449271824e-22 NA NA NA hsa-miR-192-3p ACTB -0.6401165114007 0.000266272092403814 -0.0594999724655967 0.433128836571127 MirTarget -0.114722865620584 2.28978260087367e-08 NA NA NA hsa-miR-29c-3p ACTN4 -1.4367517608807 1.61767774905781e-21 0.356064928891251 5.05249759908574e-07 mirMAP -0.125115258895195 7.1837773388298e-09 NA NA NA hsa-miR-30c-5p ACTR1A -0.432111642767632 0.000159764714931007 0.159115540278934 0.0215341604094933 miRNATAP -0.114628837411712 8.60192456496178e-05 NA NA NA hsa-miR-192-3p ACTR3 -0.6401165114007 0.000266272092403814 0.0510136297649586 0.43435255813018 MirTarget -0.123502330799841 1.30010071341171e-12 NA NA NA hsa-miR-194-5p ACTR3 -0.292530160992458 0.0996141384876663 0.0510136297649586 0.43435255813018 mirMAP -0.14015553536129 2.96983349605872e-16 NA NA NA hsa-miR-455-5p ACTR3 -0.270546034117157 0.0581320703577731 0.0510136297649586 0.43435255813018 miRanda -0.141340513603176 7.02472777745888e-11 NA NA NA hsa-miR-20a-5p ACTR3C 0.854326758727003 5.04256669663285e-07 -0.985194095129949 4.59271183901734e-09 mirMAP -0.213829247859042 8.91705073520534e-06 NA NA NA hsa-miR-20b-5p ACTR3C 0.457668023910379 0.0285865211936156 -0.985194095129949 4.59271183901734e-09 mirMAP -0.164659666997429 3.24549017687961e-05 NA NA NA hsa-miR-148a-3p ACVR1 -0.748702855596996 3.93313343865641e-07 -0.436041316598948 1.42037811134341e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.127757812095218 0.000102607735840908 NA NA NA hsa-miR-181a-5p ACVR1C 0.250113435902954 0.0551933249319293 -2.19871896765337 7.84657232630462e-19 miRNATAP -0.670634770966393 1.62470917032778e-12 NA NA NA hsa-miR-181b-5p ACVR1C 0.488256489401108 0.00105321129419701 -2.19871896765337 7.84657232630462e-19 miRNATAP -0.665132657201591 4.28032049160444e-16 NA NA NA hsa-miR-409-3p ACVR1C -0.499649792570937 0.0526751181520117 -2.19871896765337 7.84657232630462e-19 MirTarget -0.10171007159956 0.0381045111036601 NA NA NA hsa-miR-21-5p ACVR2A 1.51084295924322 1.54551622173259e-34 -0.549017310001321 8.35009567429434e-13 miRNATAP -0.169607048854855 1.73814737029117e-09 NA NA NA hsa-miR-409-3p ADAL -0.499649792570937 0.0526751181520117 -0.152716147328261 0.225630766817378 mirMAP -0.124528576814491 1.07064015045368e-07 NA NA NA hsa-miR-148a-3p ADAM10 -0.748702855596996 3.93313343865641e-07 -0.00403457779534389 0.978295883029657 MirTarget -0.110219431820108 0.02275270707882 NA NA NA hsa-miR-455-5p ADAM10 -0.270546034117157 0.0581320703577731 -0.00403457779534389 0.978295883029657 miRanda -0.175079166239213 0.000527551977771948 NA NA NA hsa-miR-29c-3p ADAM11 -1.4367517608807 1.61767774905781e-21 1.25087795197574 5.34939899503878e-07 mirMAP -0.410773074562109 9.05460125216374e-08 NA NA NA hsa-miR-455-5p ADAM15 -0.270546034117157 0.0581320703577731 1.18314808839129 7.44026159830969e-21 miRanda -0.163114049222302 0.0003119330066162 NA NA NA hsa-miR-148a-3p ADAM19 -0.748702855596996 3.93313343865641e-07 -0.32160702928448 0.0232139582513919 mirMAP -0.325649695504387 5.14611973715324e-13 NA NA NA hsa-miR-30e-5p ADAM19 -0.627815042856657 3.02205690184908e-10 -0.32160702928448 0.0232139582513919 MirTarget -0.17063321603898 0.0128078388659421 NA NA NA hsa-miR-148a-3p ADAM22 -0.748702855596996 3.93313343865641e-07 1.16776109376783 0.000384818007613429 MirTarget;miRNATAP -0.570717351275375 9.08076638454519e-08 NA NA NA hsa-miR-29c-3p ADAM22 -1.4367517608807 1.61767774905781e-21 1.16776109376783 0.000384818007613429 miRNATAP -0.456645137020027 6.2526269393795e-06 NA NA NA hsa-miR-34a-5p ADAM22 1.03694231790865 5.74864019540594e-14 1.16776109376783 0.000384818007613429 MirTarget;miRNATAP -0.294699666494387 0.00956742300285192 NA NA NA hsa-miR-455-5p ADAM22 -0.270546034117157 0.0581320703577731 1.16776109376783 0.000384818007613429 PITA;miRanda;miRNATAP -0.452526914221096 5.97775968559026e-05 NA NA NA hsa-miR-148a-3p ADAM23 -0.748702855596996 3.93313343865641e-07 1.53172738337562 0.000126500167051167 MirTarget -0.471790043846003 0.000320728545434591 NA NA NA hsa-miR-192-3p ADAM23 -0.6401165114007 0.000266272092403814 1.53172738337562 0.000126500167051167 mirMAP -0.425757678313134 0.000120784444847057 NA NA NA hsa-miR-455-5p ADAM28 -0.270546034117157 0.0581320703577731 -0.445148755425014 0.164089299522239 miRanda -0.526342776659963 1.22281255240763e-06 NA NA NA hsa-miR-20a-5p ADAM9 0.854326758727003 5.04256669663285e-07 0.469254461950823 0.0058074096052033 miRNATAP -0.235866281897525 8.13909538840547e-07 NA NA NA hsa-miR-27b-3p ADAMTS10 -0.823491817819754 9.20935302746823e-14 0.72666035489938 0.0018715247175307 MirTarget;miRNATAP -0.258537966322947 0.0105853013951589 NA NA NA hsa-miR-505-5p ADAMTS14 -0.768282569967001 1.14662846595407e-05 1.07686305285388 1.5135705287134e-05 mirMAP -0.224260041776283 0.00119799196903332 NA NA NA hsa-miR-148a-3p ADAMTS15 -0.748702855596996 3.93313343865641e-07 -0.880416409258241 0.00205636793456789 MirTarget;miRNATAP -0.407109521853394 1.22320303172348e-05 NA NA NA hsa-miR-17-3p ADAMTS15 0.410352776142368 0.00422200500748636 -0.880416409258241 0.00205636793456789 MirTarget;miRNATAP -0.41611902150875 1.74765759980328e-05 NA NA NA hsa-miR-192-3p ADAMTS15 -0.6401165114007 0.000266272092403814 -0.880416409258241 0.00205636793456789 mirMAP -0.335566330268901 2.03309408569833e-05 NA NA NA hsa-miR-148a-3p ADAMTS18 -0.748702855596996 3.93313343865641e-07 1.43554458022524 5.55511372449862e-06 miRNATAP -0.208100007448669 0.0466744182094337 NA NA NA hsa-miR-455-3p ADAMTS18 -1.3998033821095 5.72010709806871e-17 1.43554458022524 5.55511372449862e-06 PITA -0.25649314591668 0.00420877857760366 NA NA NA hsa-miR-34a-5p ADAMTS2 1.03694231790865 5.74864019540594e-14 -2.30943429471583 3.31328280089205e-13 MirTarget -0.519018870130346 3.12390850709929e-06 NA NA NA hsa-miR-148a-3p ADAMTS5 -0.748702855596996 3.93313343865641e-07 -0.158955986983549 0.364991157590809 miRNATAP -0.306850769456875 5.57468547782841e-08 NA NA NA hsa-miR-15a-5p ADAMTS5 0.349521211668244 0.000770735998804736 -0.158955986983549 0.364991157590809 miRNATAP -0.204250797100681 0.0133997675113739 NA NA NA hsa-miR-192-3p ADAMTS5 -0.6401165114007 0.000266272092403814 -0.158955986983549 0.364991157590809 mirMAP -0.244537732037194 3.22678540506101e-07 NA NA NA hsa-miR-194-5p ADAMTS5 -0.292530160992458 0.0996141384876663 -0.158955986983549 0.364991157590809 mirMAP -0.29182080610592 6.59023697726048e-10 NA NA NA hsa-miR-20a-5p ADAMTS5 0.854326758727003 5.04256669663285e-07 -0.158955986983549 0.364991157590809 miRNATAP -0.16016847364099 0.00122472300616835 NA NA NA hsa-miR-27b-3p ADAMTS6 -0.823491817819754 9.20935302746823e-14 0.701299206204912 0.00474632625270224 miRNATAP -0.259661369852688 0.0156682886243402 NA NA NA hsa-miR-29c-3p ADAMTS6 -1.4367517608807 1.61767774905781e-21 0.701299206204912 0.00474632625270224 MirTarget;miRNATAP -0.404354588728363 9.31142960146076e-08 NA NA NA hsa-miR-29c-3p ADAMTS7 -1.4367517608807 1.61767774905781e-21 0.91142277207195 1.23571565032124e-09 MirTarget;miRNATAP -0.136546078800296 0.00370240670382023 NA NA NA hsa-miR-29c-3p ADAMTS9 -1.4367517608807 1.61767774905781e-21 0.803614851989758 4.10280431675718e-06 miRNATAP -0.226837909026802 2.5981454490251e-05 NA NA NA hsa-miR-30c-5p ADAMTS9 -0.432111642767632 0.000159764714931007 0.803614851989758 4.10280431675718e-06 miRNATAP -0.193800396859917 0.00991559482811477 NA NA NA hsa-miR-17-3p ADAMTSL1 0.410352776142368 0.00422200500748636 -0.645183299106734 0.00587489922771081 mirMAP -0.33122045096589 3.00913523503579e-05 NA NA NA hsa-miR-455-5p ADAMTSL1 -0.270546034117157 0.0581320703577731 -0.645183299106734 0.00587489922771081 miRanda -0.185555355548652 0.0212205049347589 NA NA NA hsa-miR-15a-5p ADAMTSL3 0.349521211668244 0.000770735998804736 -1.85839492489896 3.61028199051418e-10 MirTarget -0.469675857159421 0.000976070660489695 NA NA NA hsa-miR-19b-3p ADAMTSL3 0.601279551368824 0.00016685097085251 -1.85839492489896 3.61028199051418e-10 miRNATAP -0.241718704577333 0.00865183436089073 NA NA NA hsa-miR-192-3p ADARB1 -0.6401165114007 0.000266272092403814 -0.132229476875825 0.222084732765285 mirMAP -0.114932530647042 0.00010812099954368 NA NA NA hsa-miR-192-5p ADARB1 -0.50188499512787 0.00344713341196035 -0.132229476875825 0.222084732765285 mirMAP -0.127398503530106 2.81068891888585e-05 NA NA NA hsa-miR-20a-5p ADARB1 0.854326758727003 5.04256669663285e-07 -0.132229476875825 0.222084732765285 MirTarget -0.112052206383323 0.000235724844781083 NA NA NA hsa-miR-455-5p ADAT1 -0.270546034117157 0.0581320703577731 -0.154666632826003 0.331011064922593 miRanda -0.246004551758331 5.11639884801838e-06 NA NA NA hsa-miR-132-3p ADCY1 0.323796239695997 0.00272093067935091 -2.70370487380383 7.2704291027202e-13 mirMAP -0.612992943094588 0.000476842117394949 NA NA NA hsa-miR-146b-5p ADCY1 0.419719546795449 0.0457375823220155 -2.70370487380383 7.2704291027202e-13 mirMAP -0.411747373321659 3.92848095012024e-06 NA NA NA hsa-miR-181a-5p ADCY1 0.250113435902954 0.0551933249319293 -2.70370487380383 7.2704291027202e-13 miRNATAP -0.332588819902657 0.0225677653398582 NA NA NA hsa-miR-181b-5p ADCY1 0.488256489401108 0.00105321129419701 -2.70370487380383 7.2704291027202e-13 miRNATAP -0.494927599091523 8.65582994023564e-05 NA NA NA hsa-miR-34a-5p ADCY1 1.03694231790865 5.74864019540594e-14 -2.70370487380383 7.2704291027202e-13 mirMAP -0.744597458152758 1.43499469738413e-08 NA NA NA hsa-miR-27b-3p ADCY3 -0.823491817819754 9.20935302746823e-14 0.145108134687769 0.339294243758741 miRNATAP -0.164435507463425 0.0118469252612308 NA NA NA hsa-miR-15a-5p ADCY5 0.349521211668244 0.000770735998804736 -1.7545347744664 9.8871180365877e-08 MirTarget;miRNATAP -0.634517464328263 5.14579027988055e-05 NA NA NA hsa-miR-27b-3p ADCY6 -0.823491817819754 9.20935302746823e-14 1.2491833959113 3.10957713063109e-35 MirTarget;miRNATAP -0.211478858423228 6.61477941867918e-06 NA NA NA hsa-miR-181a-5p ADCY9 0.250113435902954 0.0551933249319293 -0.112772641173273 0.305182803085656 miRNATAP -0.160577913908521 8.7749701933068e-05 NA NA NA hsa-miR-181b-5p ADCY9 0.488256489401108 0.00105321129419701 -0.112772641173273 0.305182803085656 miRNATAP -0.141141664717883 7.37217908544658e-05 24269684 miR 181b promotes cell proliferation and reduces apoptosis by repressing the expression of adenylyl cyclase 9 AC9 in cervical cancer cells; Phenotypic experiments indicated that miR-181b and AC9 exerted opposite effects on cell proliferation and apoptosis cervical and endocervical cancer hsa-miR-19b-3p ADCY9 0.601279551368824 0.00016685097085251 -0.112772641173273 0.305182803085656 miRNATAP -0.104173585376187 0.00172917657365646 NA NA NA hsa-miR-132-3p ADH1A 0.323796239695997 0.00272093067935091 -2.68512458013945 7.87889070276589e-14 miRNAWalker2_validate -1.26570454598493 8.26198466548329e-15 NA NA NA hsa-miR-181a-5p ADM 0.250113435902954 0.0551933249319293 -1.25701281969115 8.72037958641707e-12 MirTarget;miRNATAP -0.178178274348166 0.012027576917086 NA NA NA hsa-miR-181b-5p ADM 0.488256489401108 0.00105321129419701 -1.25701281969115 8.72037958641707e-12 MirTarget;miRNATAP -0.183092555044565 0.00296714842857999 NA NA NA hsa-miR-148a-3p ADM2 -0.748702855596996 3.93313343865641e-07 1.7229047600607 3.16835442282685e-11 mirMAP -0.426317474351994 7.21843489038708e-07 NA NA NA hsa-miR-29c-3p ADM2 -1.4367517608807 1.61767774905781e-21 1.7229047600607 3.16835442282685e-11 mirMAP -0.459329264794339 1.23550520561836e-08 NA NA NA hsa-miR-505-5p ADM2 -0.768282569967001 1.14662846595407e-05 1.7229047600607 3.16835442282685e-11 mirMAP -0.333630064921709 4.62168690845622e-06 NA NA NA hsa-miR-34a-5p ADNP 1.03694231790865 5.74864019540594e-14 0.171367872920075 0.103350599956348 miRNAWalker2_validate -0.11385833036478 0.00155548793835638 NA NA NA hsa-miR-34a-5p ADO 1.03694231790865 5.74864019540594e-14 -0.240231511983187 0.000241401535720107 miRNAWalker2_validate;MirTarget -0.108308270316774 1.09596061033657e-06 NA NA NA hsa-miR-148a-3p ADPRH -0.748702855596996 3.93313343865641e-07 -0.127900064307657 0.267398619612325 MirTarget -0.246854409712485 1.81775560789359e-11 NA NA NA hsa-miR-455-5p ADPRH -0.270546034117157 0.0581320703577731 -0.127900064307657 0.267398619612325 miRanda -0.214780325786656 3.17700165665196e-08 NA NA NA hsa-miR-30c-5p ADRA1D -0.432111642767632 0.000159764714931007 1.07242814838479 0.00499267952301502 MirTarget;miRNATAP -0.486785441356311 0.00285322263849756 NA NA NA hsa-miR-30e-5p ADRA1D -0.627815042856657 3.02205690184908e-10 1.07242814838479 0.00499267952301502 MirTarget -1.10940406756868 1.09845342553668e-09 NA NA NA hsa-miR-20a-5p ADRA2A 0.854326758727003 5.04256669663285e-07 -0.755954292905646 0.0255837717858082 miRNATAP -0.403357526197757 2.40618643447532e-05 NA NA NA hsa-miR-30e-5p ADRA2A -0.627815042856657 3.02205690184908e-10 -0.755954292905646 0.0255837717858082 MirTarget -0.529062036894358 0.00122600125614382 NA NA NA hsa-miR-192-3p AFAP1 -0.6401165114007 0.000266272092403814 0.333594871057281 0.0594854227669168 mirMAP -0.468736465143474 3.76962042177854e-24 NA NA NA hsa-miR-192-5p AFAP1 -0.50188499512787 0.00344713341196035 0.333594871057281 0.0594854227669168 mirMAP -0.48561537237124 1.2156716957883e-24 NA NA NA hsa-miR-192-5p AFAP1L1 -0.50188499512787 0.00344713341196035 0.539121502171087 1.03832634002658e-05 miRNAWalker2_validate -0.178239775876725 2.48832203322505e-07 NA NA NA hsa-miR-146b-5p AFAP1L2 0.419719546795449 0.0457375823220155 -0.547563736714806 0.000773346086336465 miRanda;miRNATAP -0.129251620129889 0.000633105725055363 NA NA NA hsa-miR-34a-5p AFAP1L2 1.03694231790865 5.74864019540594e-14 -0.547563736714806 0.000773346086336465 miRNAWalker2_validate -0.261334465816831 2.70904928149658e-06 NA NA NA hsa-miR-132-3p AFF1 0.323796239695997 0.00272093067935091 -0.706365229864835 1.27878377206924e-10 mirMAP -0.197052462215325 9.91588897283639e-05 NA NA NA hsa-miR-192-3p AFF2 -0.6401165114007 0.000266272092403814 1.39588537883969 0.000457287577801629 mirMAP -0.481916845385271 1.16704871919741e-05 NA NA NA hsa-miR-192-5p AFF2 -0.50188499512787 0.00344713341196035 1.39588537883969 0.000457287577801629 mirMAP -0.511809488487438 5.61390476636637e-06 NA NA NA hsa-miR-194-5p AFF2 -0.292530160992458 0.0996141384876663 1.39588537883969 0.000457287577801629 mirMAP -0.516766476526246 2.18012908442226e-06 NA NA NA hsa-miR-432-5p AFF2 -0.536178819038888 0.0748623258271085 1.39588537883969 0.000457287577801629 mirMAP;miRNATAP -0.195374187806758 0.00263876202626551 NA NA NA hsa-miR-132-3p AFF4 0.323796239695997 0.00272093067935091 -0.640374726233926 1.97427244265237e-11 mirMAP;miRNATAP -0.243698301082769 2.31753070989515e-08 NA NA NA hsa-miR-15a-5p AFF4 0.349521211668244 0.000770735998804736 -0.640374726233926 1.97427244265237e-11 MirTarget;miRNATAP -0.184647886731362 5.38038786951284e-05 NA NA NA hsa-miR-181a-5p AFF4 0.250113435902954 0.0551933249319293 -0.640374726233926 1.97427244265237e-11 mirMAP;miRNATAP -0.137502759738699 0.000163016276095479 NA NA NA hsa-miR-181b-5p AFF4 0.488256489401108 0.00105321129419701 -0.640374726233926 1.97427244265237e-11 mirMAP;miRNATAP -0.143174481452508 5.89379807066163e-06 NA NA NA hsa-miR-20a-5p AFF4 0.854326758727003 5.04256669663285e-07 -0.640374726233926 1.97427244265237e-11 miRNATAP -0.128546625882855 2.71936066374717e-06 NA NA NA hsa-miR-181a-5p AFG3L2 0.250113435902954 0.0551933249319293 -0.28998014178049 0.00030377062530172 MirTarget;miRNATAP -0.149698120120569 5.28086225586502e-07 NA NA NA hsa-miR-181b-5p AFG3L2 0.488256489401108 0.00105321129419701 -0.28998014178049 0.00030377062530172 MirTarget;miRNATAP -0.142360062365536 3.79557820002773e-08 NA NA NA hsa-miR-181a-5p AGFG2 0.250113435902954 0.0551933249319293 -0.0193527168337146 0.870605356857287 mirMAP -0.186057169360665 2.51414633534497e-05 NA NA NA hsa-miR-181b-5p AGFG2 0.488256489401108 0.00105321129419701 -0.0193527168337146 0.870605356857287 mirMAP -0.185383995429184 1.28072102143324e-06 NA NA NA hsa-miR-20b-5p AGFG2 0.457668023910379 0.0285865211936156 -0.0193527168337146 0.870605356857287 miRNATAP -0.100367161899126 0.000258449629603692 NA NA NA hsa-miR-181a-5p AGGF1 0.250113435902954 0.0551933249319293 0.137594763085771 0.0302630023319463 mirMAP -0.131154495183753 1.86077757233203e-08 NA NA NA hsa-miR-181b-5p AGGF1 0.488256489401108 0.00105321129419701 0.137594763085771 0.0302630023319463 mirMAP -0.115950572164104 1.06533517125863e-08 NA NA NA hsa-miR-181a-5p AGPAT3 0.250113435902954 0.0551933249319293 -0.179576731247055 0.0550734832332654 MirTarget -0.125013386177407 0.000342918356585904 NA NA NA hsa-miR-181b-5p AGPAT3 0.488256489401108 0.00105321129419701 -0.179576731247055 0.0550734832332654 MirTarget -0.114435707539793 0.000162584766447576 NA NA NA hsa-miR-192-3p AGPAT4 -0.6401165114007 0.000266272092403814 0.868498368821504 6.97076886009297e-05 mirMAP -0.309688611514618 2.56772406516042e-07 NA NA NA hsa-miR-29c-3p AGPAT4 -1.4367517608807 1.61767774905781e-21 0.868498368821504 6.97076886009297e-05 MirTarget;miRNATAP -0.370223866049547 2.97716929430795e-08 NA NA NA hsa-miR-455-3p AGPAT4 -1.3998033821095 5.72010709806871e-17 0.868498368821504 6.97076886009297e-05 mirMAP -0.248076907517164 5.37539736887939e-05 NA NA NA hsa-miR-27b-3p AGRN -0.823491817819754 9.20935302746823e-14 0.715007721538266 3.92826741843964e-07 MirTarget;miRNATAP -0.234750701169806 0.000126157039693138 NA NA NA hsa-miR-15a-5p AHCYL2 0.349521211668244 0.000770735998804736 -0.161875813443272 0.114567560639292 miRNATAP -0.108812314315305 0.0241252261324113 NA NA NA hsa-miR-148a-3p AHDC1 -0.748702855596996 3.93313343865641e-07 -0.233452674379399 0.0262629700720901 miRNATAP -0.118432059847956 0.000531083692723168 NA NA NA hsa-miR-455-5p AHI1 -0.270546034117157 0.0581320703577731 0.0665730370321114 0.63637184349978 miRanda -0.273693783088873 7.45304015134535e-09 NA NA NA hsa-miR-34a-5p AHNAK 1.03694231790865 5.74864019540594e-14 -0.0507753852017654 0.654285665013952 miRNAWalker2_validate -0.107127917786759 0.005757749475757 NA NA NA hsa-miR-182-5p AHR 1.96601340710222 4.39326175603633e-09 -0.968267522881224 8.36031294776249e-10 miRNATAP -0.12671347052275 2.09575195979123e-08 NA NA NA hsa-miR-224-3p AHR 1.40770116795301 1.31426607144612e-08 -0.968267522881224 8.36031294776249e-10 MirTarget -0.113785764122388 0.000290930810427337 NA NA NA hsa-miR-20a-5p AHRR 0.854326758727003 5.04256669663285e-07 0.374731818843264 0.0937279302372394 MirTarget -0.128518879972634 0.0428800248545702 NA NA NA hsa-miR-215-5p AHSA2 -0.981544773246509 3.14452272477156e-05 1.40797883181737 3.95534161646942e-23 miRNAWalker2_validate -0.153997744975509 4.14177573964746e-07 NA NA NA hsa-miR-30e-5p AIDA -0.627815042856657 3.02205690184908e-10 0.391907662880329 2.71263058504648e-06 MirTarget -0.155677473228584 0.000120088814087009 NA NA NA hsa-miR-21-5p AIM1 1.51084295924322 1.54551622173259e-34 -1.46469358428655 1.2646301993896e-12 miRNAWalker2_validate -0.351580360018553 4.71693671375075e-06 NA NA NA hsa-miR-455-5p AKAP10 -0.270546034117157 0.0581320703577731 -0.495734388132287 0.00585360188056289 miRanda -0.133707122889313 0.0306280779070861 NA NA NA hsa-miR-181a-5p AKAP12 0.250113435902954 0.0551933249319293 -1.35597968849681 6.58582399222702e-07 miRNAWalker2_validate -0.24688443103748 0.0173928498658619 NA NA NA hsa-miR-455-5p AKAP12 -0.270546034117157 0.0581320703577731 -1.35597968849681 6.58582399222702e-07 miRanda -0.46569010071444 6.58320763335892e-07 NA NA NA hsa-miR-146b-5p AKAP13 0.419719546795449 0.0457375823220155 -0.316044656326872 0.00142457099117573 miRanda -0.118703265432101 1.76907557590392e-07 NA NA NA hsa-miR-20a-5p AKAP13 0.854326758727003 5.04256669663285e-07 -0.316044656326872 0.00142457099117573 MirTarget;mirMAP;miRNATAP -0.12287674826508 1.06980359153594e-05 NA NA NA hsa-miR-19b-3p AKAP2 0.601279551368824 0.00016685097085251 -1.89739764962263 1.40768906126947e-06 mirMAP -0.274698493176685 0.0233910156992913 NA NA NA hsa-miR-21-5p AKAP6 1.51084295924322 1.54551622173259e-34 -0.968677768825482 1.23169099553274e-07 MirTarget -0.541064541522812 1.32687890881404e-16 NA NA NA hsa-miR-409-3p AKAP6 -0.499649792570937 0.0526751181520117 -0.968677768825482 1.23169099553274e-07 MirTarget;PITA -0.130116549339238 0.000195673040126945 NA NA NA hsa-miR-192-5p AKAP7 -0.50188499512787 0.00344713341196035 -0.934162506524967 8.3523005694695e-09 miRNAWalker2_validate -0.116255612050066 0.01300691891511 NA NA NA hsa-miR-146b-5p AKAP9 0.419719546795449 0.0457375823220155 -0.793970431680178 2.34289104389822e-08 miRanda -0.175231419701972 1.169901961131e-07 NA NA NA hsa-miR-21-5p AKAP9 1.51084295924322 1.54551622173259e-34 -0.793970431680178 2.34289104389822e-08 miRNAWalker2_validate -0.290501060527038 2.26170828191353e-08 NA NA NA hsa-miR-15a-5p AKIRIN1 0.349521211668244 0.000770735998804736 -0.726962157087393 2.07022326698311e-14 miRNATAP -0.141744857889251 0.00209987167981911 NA NA NA hsa-miR-181a-5p AKIRIN1 0.250113435902954 0.0551933249319293 -0.726962157087393 2.07022326698311e-14 MirTarget;miRNATAP -0.105063770710657 0.0042419781277249 NA NA NA hsa-miR-21-5p AKIRIN1 1.51084295924322 1.54551622173259e-34 -0.726962157087393 2.07022326698311e-14 miRNATAP -0.126515681462167 0.000383737994199711 NA NA NA hsa-miR-455-5p AKR1B15 -0.270546034117157 0.0581320703577731 2.58726823894982 2.57679312562241e-06 miRanda -0.651580983410505 0.000613779604936607 NA NA NA hsa-miR-181a-5p AKR1C1 0.250113435902954 0.0551933249319293 -0.121013255853734 0.654126652200671 mirMAP -0.59721855791776 1.96634501411262e-09 NA NA NA hsa-miR-181b-5p AKR1C1 0.488256489401108 0.00105321129419701 -0.121013255853734 0.654126652200671 mirMAP -0.524319440121615 1.37226137432425e-09 NA NA NA hsa-miR-182-5p AKR1C1 1.96601340710222 4.39326175603633e-09 -0.121013255853734 0.654126652200671 mirMAP -0.190865296214882 5.23555167058931e-07 NA NA NA hsa-miR-224-3p AKR1C1 1.40770116795301 1.31426607144612e-08 -0.121013255853734 0.654126652200671 mirMAP -0.11384323738825 0.0314119344809798 NA NA NA hsa-miR-432-5p AKR1C1 -0.536178819038888 0.0748623258271085 -0.121013255853734 0.654126652200671 mirMAP -0.102497241563575 0.0193487137825929 NA NA NA hsa-miR-21-5p AKT2 1.51084295924322 1.54551622173259e-34 -0.343608685894869 1.25471482871759e-05 miRNAWalker2_validate -0.246625533117166 4.43585626011661e-19 NA NA NA hsa-miR-146b-5p AKT3 0.419719546795449 0.0457375823220155 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate -0.159678144375669 0.000263366078999813 NA NA NA hsa-miR-15a-5p AKT3 0.349521211668244 0.000770735998804736 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265425410812535 0.00291348888530609 NA NA NA hsa-miR-17-3p AKT3 0.410352776142368 0.00422200500748636 -0.658799312069129 0.000471762262250455 miRNATAP -0.350392140268267 3.46133659001702e-08 NA NA NA hsa-miR-20a-5p AKT3 0.854326758727003 5.04256669663285e-07 -0.658799312069129 0.000471762262250455 miRNATAP -0.294574079686222 2.60181650003526e-08 NA NA NA hsa-miR-20a-5p AKTIP 0.854326758727003 5.04256669663285e-07 -0.372267282592632 0.000538928886172555 MirTarget;miRNATAP -0.250968335671779 1.42167261059228e-17 NA NA NA hsa-miR-19b-3p ALAD 0.601279551368824 0.00016685097085251 -0.92200316544688 2.31935972499156e-09 miRNAWalker2_validate -0.126812542231838 0.00795573271683322 NA NA NA hsa-miR-455-3p ALDH1A2 -1.3998033821095 5.72010709806871e-17 -0.704038124711956 0.0112369834842861 PITA -0.210525190831417 0.0070448411200052 NA NA NA hsa-miR-20a-5p ALDH1A3 0.854326758727003 5.04256669663285e-07 -2.13218776108874 9.32543225662656e-10 mirMAP -0.584921054666842 3.66358641228591e-09 NA NA NA hsa-miR-99b-5p ALDH1B1 -0.204769880349524 0.240836989110525 -1.60411395522393 4.48967687924072e-20 miRNAWalker2_validate -0.219679252925933 1.61946538900765e-05 NA NA NA hsa-miR-192-3p ALDH1L2 -0.6401165114007 0.000266272092403814 0.455013135347751 0.0446530343795595 mirMAP -0.532988497334253 7.1167341372757e-19 NA NA NA hsa-miR-194-5p ALDH1L2 -0.292530160992458 0.0996141384876663 0.455013135347751 0.0446530343795595 mirMAP -0.538133652299637 1.83349453351935e-19 NA NA NA hsa-miR-20a-5p ALDH3A2 0.854326758727003 5.04256669663285e-07 -0.549782198205341 0.000215333966024332 mirMAP -0.104054385711556 0.0140413640546679 NA NA NA hsa-miR-505-5p ALDH3B1 -0.768282569967001 1.14662846595407e-05 0.20235758093028 0.204540568786175 MirTarget -0.171500153967935 8.85456135110732e-05 NA NA NA hsa-miR-30b-5p ALG10 -0.54056186708617 2.44688760798341e-05 -0.135769096441567 0.193189255423276 MirTarget -0.208790565009123 8.10660330413044e-08 NA NA NA hsa-miR-455-3p ALPK3 -1.3998033821095 5.72010709806871e-17 1.31950289656162 7.07896178270265e-07 mirMAP -0.344168296238873 4.5124319229862e-06 NA NA NA hsa-miR-34a-5p ALS2 1.03694231790865 5.74864019540594e-14 -0.378669084168692 7.49659051291097e-06 miRNAWalker2_validate -0.18205441146874 2.0700137276203e-10 NA NA NA hsa-miR-221-3p AMOT 1.12244756358612 3.48370308238012e-13 -0.89778365109471 0.000787406411317435 miRNAWalker2_validate -0.321933225160784 9.090255444677e-05 NA NA NA hsa-miR-15a-5p AMOTL1 0.349521211668244 0.000770735998804736 -0.530839640793762 0.026029167727027 MirTarget;miRNATAP -0.361178758976199 0.00130123587752886 NA NA NA hsa-miR-146b-5p AMOTL2 0.419719546795449 0.0457375823220155 -1.28813448091337 1.58706341051733e-15 miRanda -0.143753842534241 0.000200643439640265 NA NA NA hsa-miR-182-5p AMT 1.96601340710222 4.39326175603633e-09 -0.849284315228912 5.98433042510704e-07 MirTarget -0.156111370588888 8.61173898808286e-11 NA NA NA hsa-miR-148a-3p AMZ1 -0.748702855596996 3.93313343865641e-07 -1.27523518848137 0.00014004218753246 mirMAP -0.439309250759227 6.17486486218864e-05 NA NA NA hsa-miR-146b-5p ANGPTL1 0.419719546795449 0.0457375823220155 -2.91139143461267 3.12387290064664e-17 miRanda -0.403223692759676 1.00868117925934e-06 NA NA NA hsa-miR-17-3p ANGPTL1 0.410352776142368 0.00422200500748636 -2.91139143461267 3.12387290064664e-17 MirTarget -0.505209690796112 3.1574699050036e-05 NA NA NA hsa-miR-455-5p ANGPTL1 -0.270546034117157 0.0581320703577731 -2.91139143461267 3.12387290064664e-17 miRanda -0.265622711928113 0.0310889481956742 NA NA NA hsa-miR-148a-3p ANK2 -0.748702855596996 3.93313343865641e-07 -0.936784357118896 8.39839404737194e-05 MirTarget;miRNATAP -0.442851290420514 9.87487353462611e-09 NA NA NA hsa-miR-34a-5p ANK2 1.03694231790865 5.74864019540594e-14 -0.936784357118896 8.39839404737194e-05 MirTarget;miRNATAP -0.382254600558528 2.91741890367213e-06 NA NA NA hsa-miR-34a-5p ANK3 1.03694231790865 5.74864019540594e-14 -2.36553833917389 3.37582780769611e-15 miRNATAP -0.691371655450349 3.83344109056233e-11 NA NA NA hsa-miR-19b-3p ANKIB1 0.601279551368824 0.00016685097085251 0.067345906471652 0.505512136479813 miRNATAP -0.116303896594572 0.000134509479904088 NA NA NA hsa-miR-20a-5p ANKIB1 0.854326758727003 5.04256669663285e-07 0.067345906471652 0.505512136479813 miRNATAP -0.113921563191973 5.98025631506191e-05 NA NA NA hsa-miR-455-5p ANKIB1 -0.270546034117157 0.0581320703577731 0.067345906471652 0.505512136479813 miRanda -0.147600335152444 1.64068477743234e-05 NA NA NA hsa-miR-30b-5p ANKRA2 -0.54056186708617 2.44688760798341e-05 -0.132992674514093 0.17594803012652 MirTarget -0.122356321078959 0.000953341344400888 NA NA NA hsa-miR-29c-3p ANKRD13B -1.4367517608807 1.61767774905781e-21 1.56995687270482 7.21236439677884e-16 MirTarget;miRNATAP -0.427336322891681 1.74364828061385e-12 NA NA NA hsa-miR-455-5p ANKRD13B -0.270546034117157 0.0581320703577731 1.56995687270482 7.21236439677884e-16 miRanda -0.151200694303728 0.0289556280123175 NA NA NA hsa-miR-181a-5p ANKRD13C 0.250113435902954 0.0551933249319293 -0.187927935968376 0.0180006001784129 miRNAWalker2_validate;MirTarget -0.116590413999923 8.03408707315499e-05 NA NA NA hsa-miR-455-5p ANKRD17 -0.270546034117157 0.0581320703577731 -0.340646114614708 0.00102538293672161 PITA;miRanda -0.133724875239841 0.000161988061103409 NA NA NA hsa-miR-148a-3p ANKRD27 -0.748702855596996 3.93313343865641e-07 0.900670804616695 4.42329061698872e-15 mirMAP -0.177436391740684 3.94392699827362e-06 NA NA NA hsa-miR-27b-3p ANKRD27 -0.823491817819754 9.20935302746823e-14 0.900670804616695 4.42329061698872e-15 MirTarget -0.291289051724581 7.18671140773929e-09 NA NA NA hsa-miR-455-5p ANKRD27 -0.270546034117157 0.0581320703577731 0.900670804616695 4.42329061698872e-15 PITA;miRanda -0.122491171725052 0.00254767116323907 NA NA NA hsa-miR-132-3p ANKRD28 0.323796239695997 0.00272093067935091 -0.356990023333576 5.78744492945674e-06 miRNAWalker2_validate -0.152511216335448 1.90139209982692e-05 NA NA NA hsa-miR-21-5p ANKRD28 1.51084295924322 1.54551622173259e-34 -0.356990023333576 5.78744492945674e-06 miRNAWalker2_validate -0.174630027645497 7.45048491311049e-10 NA NA NA hsa-miR-15a-5p ANKRD29 0.349521211668244 0.000770735998804736 1.13442887011441 3.88269238474571e-05 MirTarget -0.458753427952349 0.000445626462512995 NA NA NA hsa-miR-20a-5p ANKRD29 0.854326758727003 5.04256669663285e-07 1.13442887011441 3.88269238474571e-05 MirTarget -0.339619682018072 1.42784915371571e-05 NA NA NA hsa-miR-20b-5p ANKRD29 0.457668023910379 0.0285865211936156 1.13442887011441 3.88269238474571e-05 MirTarget -0.170539696415621 0.00847674006355352 NA NA NA hsa-miR-19b-3p ANKRD42 0.601279551368824 0.00016685097085251 -0.374966770178384 3.50978554793106e-05 MirTarget -0.185972491603763 5.78960703756139e-12 NA NA NA hsa-miR-21-5p ANKRD46 1.51084295924322 1.54551622173259e-34 -0.781694714145421 7.42587619630524e-10 miRNAWalker2_validate;miRTarBase -0.406156253153047 2.75148411405391e-19 21219636 Knockdown of miR-21 significantly increased the expression of ANKRD46 at both mRNA and protein levels; ANKRD46 is newly identified as a direct target of miR-21 in BC breast cancer hsa-miR-17-3p ANKRD50 0.410352776142368 0.00422200500748636 -0.252776516079819 0.0443267488846649 MirTarget;miRNATAP -0.237587925929478 1.63454062374059e-08 NA NA NA hsa-miR-181a-5p ANKRD50 0.250113435902954 0.0551933249319293 -0.252776516079819 0.0443267488846649 MirTarget;miRNATAP -0.131742321139728 0.00517791557545154 NA NA NA hsa-miR-181b-5p ANKRD50 0.488256489401108 0.00105321129419701 -0.252776516079819 0.0443267488846649 MirTarget;miRNATAP -0.111613112295002 0.00648394189363301 NA NA NA hsa-miR-20a-5p ANKRD50 0.854326758727003 5.04256669663285e-07 -0.252776516079819 0.0443267488846649 MirTarget;miRNATAP -0.204431209041044 5.30055881780065e-09 NA NA NA hsa-miR-148a-3p ANKRD52 -0.748702855596996 3.93313343865641e-07 1.45719998646575 1.747377108051e-36 mirMAP;miRNATAP -0.254983576295231 2.94153541356069e-10 NA NA NA hsa-miR-192-3p ANKRD52 -0.6401165114007 0.000266272092403814 1.45719998646575 1.747377108051e-36 mirMAP -0.198127230193821 7.94600390954342e-09 NA NA NA hsa-miR-192-5p ANKRD52 -0.50188499512787 0.00344713341196035 1.45719998646575 1.747377108051e-36 mirMAP -0.161920111656283 5.09500737908452e-06 NA NA NA hsa-miR-27b-3p ANKRD52 -0.823491817819754 9.20935302746823e-14 1.45719998646575 1.747377108051e-36 miRNAWalker2_validate -0.284938653452139 1.13235136495351e-07 NA NA NA hsa-miR-29c-3p ANKRD52 -1.4367517608807 1.61767774905781e-21 1.45719998646575 1.747377108051e-36 MirTarget;miRNATAP -0.382692935525422 1.36547375414266e-25 NA NA NA hsa-miR-30c-5p ANKRD52 -0.432111642767632 0.000159764714931007 1.45719998646575 1.747377108051e-36 miRNATAP -0.147210467045776 0.00619669943585396 NA NA NA hsa-miR-505-5p ANKRD52 -0.768282569967001 1.14662846595407e-05 1.45719998646575 1.747377108051e-36 MirTarget;miRNATAP -0.167844968284628 1.14812279006559e-06 NA NA NA hsa-miR-148a-3p ANKS6 -0.748702855596996 3.93313343865641e-07 0.759243866236994 0.0152104928778901 mirMAP -0.627092112569914 4.43139828118081e-10 NA NA NA hsa-miR-192-5p ANLN -0.50188499512787 0.00344713341196035 3.88656909930585 1.21152402703192e-46 miRNAWalker2_validate -0.203999078919904 0.0182411785223461 NA NA NA hsa-miR-215-5p ANLN -0.981544773246509 3.14452272477156e-05 3.88656909930585 1.21152402703192e-46 miRNAWalker2_validate -0.175179870303222 0.00495204547134963 NA NA NA hsa-miR-19b-3p ANO1 0.601279551368824 0.00016685097085251 -2.23371833074271 6.73977010602325e-12 MirTarget;miRNATAP -0.260804998579913 0.0102480180365033 NA NA NA hsa-miR-19b-3p ANO3 0.601279551368824 0.00016685097085251 -2.29674689433524 3.8766367804959e-09 miRNATAP -0.361769970137119 0.00271860174512941 NA NA NA hsa-miR-21-5p ANO3 1.51084295924322 1.54551622173259e-34 -2.29674689433524 3.8766367804959e-09 mirMAP -0.983667262898009 3.76138226056672e-12 NA NA NA hsa-miR-30e-5p ANO4 -0.627815042856657 3.02205690184908e-10 1.35799914292886 3.42007165442038e-06 MirTarget -0.627407304148621 9.86888411063048e-06 NA NA NA hsa-miR-455-5p ANO4 -0.270546034117157 0.0581320703577731 1.35799914292886 3.42007165442038e-06 miRanda -0.420648473246223 2.9413517813741e-05 NA NA NA hsa-miR-20a-5p ANO6 0.854326758727003 5.04256669663285e-07 -0.291765828721766 0.00463644529629324 MirTarget -0.106904979606777 0.00023908900938888 NA NA NA hsa-miR-34a-5p ANP32B 1.03694231790865 5.74864019540594e-14 -0.0226391349433763 0.806282020109498 miRNATAP -0.13829097174882 1.00574931435793e-05 NA NA NA hsa-miR-19b-3p ANTXR1 0.601279551368824 0.00016685097085251 -0.48250313082928 0.04008545083989 MirTarget -0.284260896832564 6.38597077542781e-05 NA NA NA hsa-miR-30e-5p ANTXR1 -0.627815042856657 3.02205690184908e-10 -0.48250313082928 0.04008545083989 mirMAP -0.225722082718949 0.0476008305466785 NA NA NA hsa-miR-455-5p ANTXR2 -0.270546034117157 0.0581320703577731 -1.46615350419417 9.74591534416521e-25 miRanda -0.12221130498752 0.0185897657644492 NA NA NA hsa-miR-30c-5p ANXA11 -0.432111642767632 0.000159764714931007 0.351931703132002 4.07367680220268e-05 mirMAP -0.143086111815439 8.92303697764093e-05 NA NA NA hsa-miR-30e-5p ANXA11 -0.627815042856657 3.02205690184908e-10 0.351931703132002 4.07367680220268e-05 mirMAP -0.322043752491144 1.24354480593299e-15 NA NA NA hsa-miR-146b-5p ANXA3 0.419719546795449 0.0457375823220155 -2.62089554349329 1.14883781161726e-13 miRanda -0.28661619556096 0.00066931028499601 NA NA NA hsa-miR-148a-3p ANXA4 -0.748702855596996 3.93313343865641e-07 -0.204045790335896 0.167003285162076 MirTarget -0.35947112824918 1.42075019192064e-14 NA NA NA hsa-miR-34a-5p ANXA4 1.03694231790865 5.74864019540594e-14 -0.204045790335896 0.167003285162076 miRNAWalker2_validate -0.140633153382514 0.00547810973631272 NA NA NA hsa-miR-146b-5p AOC3 0.419719546795449 0.0457375823220155 -0.852357919238112 1.89555598424004e-10 miRanda -0.1030429140777 0.0011202774979939 NA NA NA hsa-miR-21-5p AP1AR 1.51084295924322 1.54551622173259e-34 -0.606234109288887 7.43586488835338e-08 MirTarget;miRNATAP -0.254779994139421 4.6831692514021e-10 NA NA NA hsa-miR-181a-5p AP1G1 0.250113435902954 0.0551933249319293 -0.476980051128284 2.74183835894147e-09 miRNATAP -0.1623083304393 7.3264680185055e-08 NA NA NA hsa-miR-181b-5p AP1G1 0.488256489401108 0.00105321129419701 -0.476980051128284 2.74183835894147e-09 miRNATAP -0.136421575290936 2.0456925590208e-07 NA NA NA hsa-miR-19b-3p AP1G1 0.601279551368824 0.00016685097085251 -0.476980051128284 2.74183835894147e-09 miRNATAP -0.169264270617969 2.2318983024835e-12 NA NA NA hsa-miR-652-3p AP1G1 0.135945800164278 0.391695970197646 -0.476980051128284 2.74183835894147e-09 miRNAWalker2_validate -0.104490113515397 2.77071051733338e-05 NA NA NA hsa-miR-192-5p AP1S2 -0.50188499512787 0.00344713341196035 -0.395973387919881 0.000493972914950454 miRNAWalker2_validate -0.327460865551955 3.57573083470452e-27 NA NA NA hsa-miR-455-5p AP1S2 -0.270546034117157 0.0581320703577731 -0.395973387919881 0.000493972914950454 miRanda -0.18464183928592 1.82680241881429e-06 NA NA NA hsa-miR-30b-5p AP2A1 -0.54056186708617 2.44688760798341e-05 0.191339113399971 0.0090307625672161 miRNAWalker2_validate;miRNATAP -0.140020673666954 3.1066743260237e-07 NA NA NA hsa-miR-455-5p AP3B1 -0.270546034117157 0.0581320703577731 0.632267344636405 1.63239533876199e-17 miRanda -0.136579356826373 1.53354434956686e-07 NA NA NA hsa-miR-192-5p AP3M2 -0.50188499512787 0.00344713341196035 0.873042146815553 2.35328106646397e-15 miRNAWalker2_validate -0.278654218086517 2.0527304232252e-19 NA NA NA hsa-miR-215-5p AP3M2 -0.981544773246509 3.14452272477156e-05 0.873042146815553 2.35328106646397e-15 miRNAWalker2_validate -0.106550178241087 4.14318933913069e-06 NA NA NA hsa-miR-20a-5p APBB2 0.854326758727003 5.04256669663285e-07 -0.236685537022579 0.0308537760053906 MirTarget;miRNATAP -0.191936597293415 2.83430270311816e-10 NA NA NA hsa-miR-21-5p APC 1.51084295924322 1.54551622173259e-34 -0.178106776451097 0.0679159506996304 miRNAWalker2_validate -0.170963654395431 1.15664392926358e-06 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-miR-505-5p APC2 -0.768282569967001 1.14662846595407e-05 1.72078641102954 8.65364092042936e-19 mirMAP -0.146052163078095 0.00923653240014872 NA NA NA hsa-miR-20a-5p APCDD1 0.854326758727003 5.04256669663285e-07 -1.30282968453375 0.000425498278202489 MirTarget -0.340479221311948 0.00121126699273569 NA NA NA hsa-miR-181a-5p API5 0.250113435902954 0.0551933249319293 -0.322976149788153 2.1337750512996e-08 MirTarget -0.179985416195864 8.62189814259411e-18 NA NA NA hsa-miR-181b-5p API5 0.488256489401108 0.00105321129419701 -0.322976149788153 2.1337750512996e-08 MirTarget -0.1603804940941 1.13508903128198e-18 NA NA NA hsa-miR-30b-5p APLN -0.54056186708617 2.44688760798341e-05 3.68748588694903 4.52095574250086e-43 miRNAWalker2_validate -0.393879003995436 0.000479137210501393 NA NA NA hsa-miR-30c-5p APLN -0.432111642767632 0.000159764714931007 3.68748588694903 4.52095574250086e-43 miRNAWalker2_validate -0.323522294542745 0.0109866696655126 NA NA NA hsa-miR-455-3p APLN -1.3998033821095 5.72010709806871e-17 3.68748588694903 4.52095574250086e-43 MirTarget;miRNATAP -0.261680600223833 0.00175194516081339 NA NA NA hsa-miR-15a-5p APLNR 0.349521211668244 0.000770735998804736 -0.977972128143673 8.97237243860362e-05 MirTarget -0.450958755712188 0.000132924768526459 NA NA NA hsa-miR-21-5p APOLD1 1.51084295924322 1.54551622173259e-34 0.453740241904891 0.00928610512501684 miRNAWalker2_validate -0.1771891442795 0.0054502772943704 NA NA NA hsa-miR-15a-5p APP 0.349521211668244 0.000770735998804736 -0.63175643594434 0.000103428491144879 miRNAWalker2_validate;miRNATAP -0.182347067557465 0.018264121507757 NA NA NA hsa-miR-146b-5p AQP1 0.419719546795449 0.0457375823220155 -0.674685617939914 0.00310290054638203 miRanda -0.177811537423959 0.000785767847562105 NA NA NA hsa-miR-221-3p AQP3 1.12244756358612 3.48370308238012e-13 -1.90428727360161 1.63416767229399e-21 MirTarget -0.171766599201336 0.00794925207301195 NA NA NA hsa-miR-409-3p AQP4 -0.499649792570937 0.0526751181520117 -2.60269555649257 1.10014775225101e-10 mirMAP -0.158736955642299 0.0420455445828748 NA NA NA hsa-miR-132-3p AR 0.323796239695997 0.00272093067935091 -2.65514434874701 6.79656050811819e-11 mirMAP -1.02664692740533 3.6724731555719e-08 NA NA NA hsa-miR-146a-5p AR -0.742958238440575 0.000765983177482633 -2.65514434874701 6.79656050811819e-11 mirMAP -0.423161029738674 3.10662522706658e-06 25123132 To study the cellular response to miR-146a upregulation in p53-impaired basal-like lines antagomir KD of miR-146a was performed; KD of miR-146a caused decreased proliferation and increased apoptosis effectively ablating the effects of p53 loss drug resistance breast cancer hsa-miR-181a-5p AR 0.250113435902954 0.0551933249319293 -2.65514434874701 6.79656050811819e-11 miRNATAP -1.22886594580632 4.1868974504783e-16 NA NA NA hsa-miR-181b-5p AR 0.488256489401108 0.00105321129419701 -2.65514434874701 6.79656050811819e-11 miRNATAP -1.29824857260422 6.54962591623091e-24 NA NA NA hsa-miR-19b-3p AR 0.601279551368824 0.00016685097085251 -2.65514434874701 6.79656050811819e-11 mirMAP -0.682837043449393 4.61947892618391e-08 NA NA NA hsa-miR-20a-5p AR 0.854326758727003 5.04256669663285e-07 -2.65514434874701 6.79656050811819e-11 mirMAP -0.725850826781021 3.75624697520003e-10 NA NA NA hsa-miR-20b-5p AR 0.457668023910379 0.0285865211936156 -2.65514434874701 6.79656050811819e-11 mirMAP -0.370935607734088 0.000123857294145519 NA NA NA hsa-miR-432-5p AR -0.536178819038888 0.0748623258271085 -2.65514434874701 6.79656050811819e-11 mirMAP -0.258158742479427 0.000126567740090846 NA NA NA hsa-miR-148a-3p ARAP2 -0.748702855596996 3.93313343865641e-07 -1.13466869294013 1.21001797842144e-11 MirTarget -0.263514528901823 2.11834622572004e-06 NA NA NA hsa-miR-19b-3p ARAP2 0.601279551368824 0.00016685097085251 -1.13466869294013 1.21001797842144e-11 MirTarget -0.166725075921007 0.00135756137820677 NA NA NA hsa-miR-20a-5p ARAP2 0.854326758727003 5.04256669663285e-07 -1.13466869294013 1.21001797842144e-11 MirTarget -0.20944314137112 1.44427566523601e-05 NA NA NA hsa-miR-221-3p ARAP2 1.12244756358612 3.48370308238012e-13 -1.13466869294013 1.21001797842144e-11 MirTarget -0.139559068683898 0.00818110075154483 NA NA NA hsa-miR-192-5p ARF3 -0.50188499512787 0.00344713341196035 0.177253463256622 0.00421607027312191 mirMAP -0.138664075567025 1.8621761611359e-16 NA NA NA hsa-miR-27b-3p ARF3 -0.823491817819754 9.20935302746823e-14 0.177253463256622 0.00421607027312191 MirTarget -0.149025281031523 1.19134496034957e-08 NA NA NA hsa-miR-181a-5p ARFGEF2 0.250113435902954 0.0551933249319293 0.0424551780056248 0.707114343548082 MirTarget;miRNATAP -0.145031077863132 0.000577258765137616 NA NA NA hsa-miR-181b-5p ARFGEF2 0.488256489401108 0.00105321129419701 0.0424551780056248 0.707114343548082 MirTarget;miRNATAP -0.105659517208244 0.00401934990541995 NA NA NA hsa-miR-19b-3p ARFIP1 0.601279551368824 0.00016685097085251 -0.205877254967544 0.00812115232004465 MirTarget;miRNATAP -0.151617220316142 4.88748847363874e-11 NA NA NA hsa-miR-19b-3p ARHGAP12 0.601279551368824 0.00016685097085251 0.0370899211582838 0.722482993769925 miRNAWalker2_validate;miRNATAP -0.116600808320263 0.000211315139249349 NA NA NA hsa-miR-27b-3p ARHGAP12 -0.823491817819754 9.20935302746823e-14 0.0370899211582838 0.722482993769925 miRNATAP -0.108189350969651 0.0158461411311389 NA NA NA hsa-miR-455-5p ARHGAP17 -0.270546034117157 0.0581320703577731 0.122001156894005 0.066958721231899 miRanda -0.106464375619572 2.07434543689801e-06 NA NA NA hsa-miR-29c-3p ARHGAP19 -1.4367517608807 1.61767774905781e-21 0.489045209278053 1.60619056308168e-07 mirMAP -0.187433904583076 4.33319640924656e-11 NA NA NA hsa-miR-505-5p ARHGAP19 -0.768282569967001 1.14662846595407e-05 0.489045209278053 1.60619056308168e-07 mirMAP -0.114771476692462 9.06499692587954e-06 NA NA NA hsa-miR-21-5p ARHGAP21 1.51084295924322 1.54551622173259e-34 -0.0901325619855351 0.372735683508637 miRNAWalker2_validate -0.109477885593189 0.00286441130824444 NA NA NA hsa-miR-20a-5p ARHGAP23 0.854326758727003 5.04256669663285e-07 -0.144534678234969 0.329845622280863 mirMAP -0.179798589478187 1.58782570453225e-05 NA NA NA hsa-miR-194-5p ARHGAP24 -0.292530160992458 0.0996141384876663 -0.989759863701917 1.90104401611984e-08 miRNATAP -0.14763248662455 0.00266204155533107 NA NA NA hsa-miR-20a-5p ARHGAP24 0.854326758727003 5.04256669663285e-07 -0.989759863701917 1.90104401611984e-08 MirTarget -0.239221669437707 1.94621639898914e-06 NA NA NA hsa-miR-21-5p ARHGAP24 1.51084295924322 1.54551622173259e-34 -0.989759863701917 1.90104401611984e-08 MirTarget;miRNATAP -0.361321405537448 2.02161621269502e-08 NA NA NA hsa-miR-455-5p ARHGAP27 -0.270546034117157 0.0581320703577731 0.305426275451165 0.0306499705221939 miRanda -0.18882541236176 8.80363701330703e-05 NA NA NA hsa-miR-455-5p ARHGAP28 -0.270546034117157 0.0581320703577731 0.592716397637913 0.0330797805481668 miRanda -0.364052056468905 0.000125888523335128 NA NA NA hsa-miR-132-3p ARHGAP32 0.323796239695997 0.00272093067935091 -0.199023023372693 0.099211320915758 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.192057790481427 0.000422687220060001 NA NA NA hsa-miR-146a-5p ARHGAP32 -0.742958238440575 0.000765983177482633 -0.199023023372693 0.099211320915758 mirMAP -0.107181009547051 4.62377527673774e-05 NA NA NA hsa-miR-181a-5p ARHGAP32 0.250113435902954 0.0551933249319293 -0.199023023372693 0.099211320915758 mirMAP -0.133359787450853 0.00316356243113345 NA NA NA hsa-miR-181b-5p ARHGAP32 0.488256489401108 0.00105321129419701 -0.199023023372693 0.099211320915758 mirMAP -0.145074366816109 0.000213938697578004 NA NA NA hsa-miR-21-5p ARHGAP32 1.51084295924322 1.54551622173259e-34 -0.199023023372693 0.099211320915758 MirTarget -0.291141695246814 1.24484805534917e-11 NA NA NA hsa-miR-221-3p ARHGAP42 1.12244756358612 3.48370308238012e-13 -1.24308952548647 4.86146691234769e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.402522335066655 1.85507356799353e-15 NA NA NA hsa-miR-455-5p ARHGAP42 -0.270546034117157 0.0581320703577731 -1.24308952548647 4.86146691234769e-14 miRanda -0.21511175842494 0.000211565545757695 NA NA NA hsa-miR-15a-5p ARHGAP5 0.349521211668244 0.000770735998804736 -0.390501975399923 8.01729872271933e-05 MirTarget;miRNATAP -0.140114967228855 0.00276448285918912 NA NA NA hsa-miR-181a-5p ARHGAP5 0.250113435902954 0.0551933249319293 -0.390501975399923 8.01729872271933e-05 mirMAP -0.178285338979484 1.42745874554536e-06 NA NA NA hsa-miR-181b-5p ARHGAP5 0.488256489401108 0.00105321129419701 -0.390501975399923 8.01729872271933e-05 mirMAP -0.156486821983914 1.13906378427161e-06 NA NA NA hsa-miR-19b-3p ARHGAP5 0.601279551368824 0.00016685097085251 -0.390501975399923 8.01729872271933e-05 miRNATAP -0.126249258755046 2.62351845075989e-05 NA NA NA hsa-miR-146b-5p ARHGAP6 0.419719546795449 0.0457375823220155 0.221635683333151 0.193992053311088 PITA;miRanda -0.107586349960902 0.00647010942917499 NA NA NA hsa-miR-192-5p ARHGEF10 -0.50188499512787 0.00344713341196035 0.0457284063732661 0.788871825212443 miRNAWalker2_validate -0.424443709514871 3.75969294346877e-20 NA NA NA hsa-miR-15a-5p ARHGEF12 0.349521211668244 0.000770735998804736 -0.860756828496805 1.466966277395e-15 MirTarget -0.282479585164631 5.13490039821753e-08 NA NA NA hsa-miR-17-3p ARHGEF12 0.410352776142368 0.00422200500748636 -0.860756828496805 1.466966277395e-15 MirTarget -0.208931736726904 2.29562067109369e-08 NA NA NA hsa-miR-19b-3p ARHGEF12 0.601279551368824 0.00016685097085251 -0.860756828496805 1.466966277395e-15 MirTarget;mirMAP;miRNATAP -0.200858519074373 1.63885185941101e-09 NA NA NA hsa-miR-21-5p ARHGEF12 1.51084295924322 1.54551622173259e-34 -0.860756828496805 1.466966277395e-15 miRNAWalker2_validate;MirTarget -0.259576540298464 7.48464022130423e-11 NA NA NA hsa-miR-455-5p ARHGEF12 -0.270546034117157 0.0581320703577731 -0.860756828496805 1.466966277395e-15 MirTarget;miRNATAP -0.112075538797026 0.00332346847492632 NA NA NA hsa-miR-148a-3p ARHGEF17 -0.748702855596996 3.93313343865641e-07 0.063804626387558 0.699136901516712 miRNATAP -0.457419364506958 7.79553515305781e-19 NA NA NA hsa-miR-455-5p ARHGEF17 -0.270546034117157 0.0581320703577731 0.063804626387558 0.699136901516712 miRanda -0.166165773784993 0.00319608657432163 NA NA NA hsa-miR-27b-3p ARHGEF37 -0.823491817819754 9.20935302746823e-14 1.10732664939969 7.07735549130854e-06 MirTarget -0.257123731542649 0.0167140143678827 NA NA NA hsa-miR-146b-5p ARHGEF4 0.419719546795449 0.0457375823220155 -1.68809750287374 2.53766305327756e-05 miRanda -0.267723058999981 0.00429847378483684 NA NA NA hsa-miR-30b-5p ARHGEF6 -0.54056186708617 2.44688760798341e-05 -0.583348603456455 0.000118289545402769 MirTarget -0.146380011993689 0.0113754787311568 NA NA NA hsa-miR-30b-5p ARHGEF9 -0.54056186708617 2.44688760798341e-05 0.259646650357336 0.0114230958518346 mirMAP -0.141776351972825 0.000252965227345607 NA NA NA hsa-miR-29c-3p ARID3A -1.4367517608807 1.61767774905781e-21 1.53198637867813 1.48041716318634e-09 mirMAP -0.737952797868609 1.56695605067584e-22 NA NA NA hsa-miR-30b-5p ARID3A -0.54056186708617 2.44688760798341e-05 1.53198637867813 1.48041716318634e-09 miRNAWalker2_validate;mirMAP -0.257368567220223 0.00865333757463069 NA NA NA hsa-miR-30e-5p ARID3A -0.627815042856657 3.02205690184908e-10 1.53198637867813 1.48041716318634e-09 mirMAP -0.499192815951663 5.93071721524847e-05 NA NA NA hsa-miR-21-5p ARID4A 1.51084295924322 1.54551622173259e-34 -0.895975441173601 4.13512367982488e-14 miRNAWalker2_validate -0.430336670497644 1.70726642436494e-24 NA NA NA hsa-miR-34a-5p ARID4A 1.03694231790865 5.74864019540594e-14 -0.895975441173601 4.13512367982488e-14 miRNATAP -0.180537983837051 1.49200953966219e-05 NA NA NA hsa-miR-17-3p ARID4B 0.410352776142368 0.00422200500748636 0.234755747131405 0.0124417716725212 miRNAWalker2_validate -0.105970573854466 0.000865440937036983 NA NA NA hsa-miR-192-3p ARID5B -0.6401165114007 0.000266272092403814 -0.51790455974164 0.000116493206015505 miRNATAP -0.147513993720732 7.20410728693333e-05 NA NA NA hsa-miR-192-5p ARID5B -0.50188499512787 0.00344713341196035 -0.51790455974164 0.000116493206015505 mirMAP -0.160948774805613 2.38284113447348e-05 NA NA NA hsa-miR-132-3p ARIH1 0.323796239695997 0.00272093067935091 -0.131545607366657 0.0699251677277551 MirTarget -0.108413716397033 0.000896519157457096 NA NA NA hsa-miR-181a-5p ARIH1 0.250113435902954 0.0551933249319293 -0.131545607366657 0.0699251677277551 MirTarget;mirMAP -0.130279323923282 1.1821682367591e-06 NA NA NA hsa-miR-181b-5p ARIH1 0.488256489401108 0.00105321129419701 -0.131545607366657 0.0699251677277551 MirTarget;mirMAP -0.125581048645029 6.59565969581704e-08 NA NA NA hsa-miR-20a-5p ARL10 0.854326758727003 5.04256669663285e-07 -0.416388129451091 0.0155583304348665 mirMAP -0.101112777931085 0.0387491076874815 NA NA NA hsa-miR-224-3p ARL11 1.40770116795301 1.31426607144612e-08 -0.76199287836168 8.55203756856903e-06 mirMAP -0.111378743050174 0.000975321142273788 NA NA NA hsa-miR-20a-5p ARL13B 0.854326758727003 5.04256669663285e-07 -0.316629429743313 0.0119647415921429 MirTarget -0.114333354634642 0.00134104046938039 NA NA NA hsa-miR-30b-5p ARL13B -0.54056186708617 2.44688760798341e-05 -0.316629429743313 0.0119647415921429 MirTarget;mirMAP -0.111651262143669 0.0195918381663734 NA NA NA hsa-miR-30b-5p ARL15 -0.54056186708617 2.44688760798341e-05 -0.0844459155420325 0.530391286462236 MirTarget -0.121364631592737 0.0171742492820179 NA NA NA hsa-miR-30b-5p ARL4A -0.54056186708617 2.44688760798341e-05 0.461216377404285 0.00448047411295597 MirTarget -0.178666947165943 0.00374122989035006 NA NA NA hsa-miR-30c-5p ARL4A -0.432111642767632 0.000159764714931007 0.461216377404285 0.00448047411295597 MirTarget -0.160227419995227 0.0209534514716344 NA NA NA hsa-miR-30e-5p ARL4A -0.627815042856657 3.02205690184908e-10 0.461216377404285 0.00448047411295597 MirTarget -0.21306249164483 0.00673766356385419 NA NA NA hsa-miR-192-5p ARL4C -0.50188499512787 0.00344713341196035 -0.828784149026158 1.2682062092253e-05 miRNAWalker2_validate -0.445961050684204 1.44230749334181e-17 NA NA NA hsa-miR-20a-5p ARL4C 0.854326758727003 5.04256669663285e-07 -0.828784149026158 1.2682062092253e-05 MirTarget;miRNATAP -0.110688777952846 0.0418836797572384 NA NA NA hsa-miR-215-5p ARL4C -0.981544773246509 3.14452272477156e-05 -0.828784149026158 1.2682062092253e-05 miRNAWalker2_validate -0.110290667068056 0.00493880898254631 NA NA NA hsa-miR-15a-5p ARMCX2 0.349521211668244 0.000770735998804736 -0.582047155561455 0.00217278516727805 MirTarget;miRNATAP -0.305729995964281 0.000639909818284133 NA NA NA hsa-miR-455-5p ARMCX3 -0.270546034117157 0.0581320703577731 -1.24741704057309 1.67840682950928e-06 MirTarget;miRanda;miRNATAP -0.460339790966538 2.50665527472117e-07 NA NA NA hsa-miR-192-5p ARNTL2 -0.50188499512787 0.00344713341196035 0.0223855120215825 0.941117167316514 miRNAWalker2_validate -0.265231940122221 0.00196654272615323 NA NA NA hsa-miR-30e-5p ARPC5 -0.627815042856657 3.02205690184908e-10 0.68549906803262 8.37228375149115e-19 MirTarget -0.208742415753219 5.50863994076996e-08 NA NA NA hsa-miR-455-5p ARPP19 -0.270546034117157 0.0581320703577731 0.0812891793793611 0.262068184569468 miRanda -0.100260619151421 4.27261270664391e-05 NA NA NA hsa-miR-181a-5p ARRDC3 0.250113435902954 0.0551933249319293 -0.701093957153481 3.22762889898878e-06 MirTarget;mirMAP;miRNATAP -0.187140766538602 0.00102409536657809 NA NA NA hsa-miR-181b-5p ARRDC3 0.488256489401108 0.00105321129419701 -0.701093957153481 3.22762889898878e-06 MirTarget;mirMAP;miRNATAP -0.19578924636293 7.46009942548185e-05 NA NA NA hsa-miR-455-5p ARSB -0.270546034117157 0.0581320703577731 0.000213595126902444 0.998666562553238 miRanda -0.102192039365202 0.0192885488189501 NA NA NA hsa-miR-20a-5p ARSD 0.854326758727003 5.04256669663285e-07 -1.15703048361889 2.52321723033514e-14 mirMAP -0.325380843692538 4.50390878399019e-14 NA NA NA hsa-miR-20b-5p ARSD 0.457668023910379 0.0285865211936156 -1.15703048361889 2.52321723033514e-14 mirMAP -0.152129312154428 2.74652548296137e-05 NA NA NA hsa-miR-21-5p ART4 1.51084295924322 1.54551622173259e-34 -1.74425490375507 1.67364109265157e-09 mirMAP -0.483938253913385 6.01331559838995e-06 NA NA NA hsa-miR-194-5p ASAP1 -0.292530160992458 0.0996141384876663 0.602171250732936 1.27059865202179e-05 MirTarget;miRNATAP -0.359762874594349 3.05186765984754e-23 NA NA NA hsa-miR-19b-3p ASAP2 0.601279551368824 0.00016685097085251 0.6918615834828 2.49307195490073e-05 MirTarget;miRNATAP -0.244041140803753 9.45027199981592e-07 NA NA NA hsa-miR-30b-5p ASAP2 -0.54056186708617 2.44688760798341e-05 0.6918615834828 2.49307195490073e-05 mirMAP -0.171292094276898 0.00631967606803768 NA NA NA hsa-miR-29c-3p ASB1 -1.4367517608807 1.61767774905781e-21 0.205969958581636 0.040797493321459 mirMAP -0.155196927825263 3.90009953618695e-07 NA NA NA hsa-miR-30c-5p ASB1 -0.432111642767632 0.000159764714931007 0.205969958581636 0.040797493321459 mirMAP -0.103487013818758 0.015731666850985 NA NA NA hsa-miR-30e-5p ASB1 -0.627815042856657 3.02205690184908e-10 0.205969958581636 0.040797493321459 mirMAP -0.232387793400062 1.36068547603405e-06 NA NA NA hsa-miR-181b-5p ASB13 0.488256489401108 0.00105321129419701 -0.761648880670108 5.02646663365169e-08 miRNAWalker2_validate -0.382795548186767 8.09796222428554e-18 NA NA NA hsa-miR-221-3p ASB4 1.12244756358612 3.48370308238012e-13 -0.619984466341846 0.0668344671524796 MirTarget -0.338696773167931 0.00111155215175412 NA NA NA hsa-miR-222-3p ASB4 1.08574156066353 1.76407192348131e-11 -0.619984466341846 0.0668344671524796 MirTarget -0.493976999384886 5.77140728352738e-07 NA NA NA hsa-miR-221-3p ASB7 1.12244756358612 3.48370308238012e-13 -0.199738778844576 0.00927477847644337 miRNATAP -0.101705955765497 1.34211428398082e-05 NA NA NA hsa-miR-30b-5p ASCC3 -0.54056186708617 2.44688760798341e-05 0.0310756465752471 0.784251058541654 MirTarget -0.170890752888657 6.1295270477658e-05 NA NA NA hsa-miR-19b-3p ASNA1 0.601279551368824 0.00016685097085251 0.581579212663772 5.45618031422578e-12 MirTarget;miRNATAP -0.123636102973371 1.92378827925859e-06 NA NA NA hsa-miR-181a-5p ASPA 0.250113435902954 0.0551933249319293 -2.87708424623409 2.78732403857851e-24 mirMAP -0.352963944636362 0.00170585619142801 NA NA NA hsa-miR-181b-5p ASPA 0.488256489401108 0.00105321129419701 -2.87708424623409 2.78732403857851e-24 mirMAP -0.463818940856489 1.78856178519175e-06 NA NA NA hsa-miR-20a-5p ASPA 0.854326758727003 5.04256669663285e-07 -2.87708424623409 2.78732403857851e-24 mirMAP -0.228916734793071 0.007122528796685 NA NA NA hsa-miR-221-3p ASPA 1.12244756358612 3.48370308238012e-13 -2.87708424623409 2.78732403857851e-24 MirTarget -0.664434785455406 1.31990121226134e-13 NA NA NA hsa-miR-222-3p ASPA 1.08574156066353 1.76407192348131e-11 -2.87708424623409 2.78732403857851e-24 MirTarget -0.557862349964748 1.29783767881019e-10 NA NA NA hsa-miR-224-3p ASPA 1.40770116795301 1.31426607144612e-08 -2.87708424623409 2.78732403857851e-24 mirMAP -0.230035784165903 8.42394385353825e-05 NA NA NA hsa-miR-181a-5p ASPH 0.250113435902954 0.0551933249319293 0.471205919674361 0.00524665556215563 mirMAP -0.127208493493615 0.0456061238316322 NA NA NA hsa-miR-192-5p ASPH -0.50188499512787 0.00344713341196035 0.471205919674361 0.00524665556215563 miRNAWalker2_validate -0.106928181337855 0.0260299670438736 NA NA NA hsa-miR-455-5p ASPH -0.270546034117157 0.0581320703577731 0.471205919674361 0.00524665556215563 miRanda -0.178427827804055 0.00204668633626461 NA NA NA hsa-miR-192-3p ASPN -0.6401165114007 0.000266272092403814 -1.64007252962853 7.34792651154405e-10 MirTarget -0.341817822852311 4.50759801696661e-06 NA NA NA hsa-miR-21-5p ASPN 1.51084295924322 1.54551622173259e-34 -1.64007252962853 7.34792651154405e-10 MirTarget;miRNATAP -0.195771684549619 0.0490195828246832 NA NA NA hsa-miR-15a-5p ASTN1 0.349521211668244 0.000770735998804736 -1.44041538863661 1.4737393473242e-07 MirTarget -0.459409660558686 0.000438800614095261 NA NA NA hsa-miR-17-3p ASTN1 0.410352776142368 0.00422200500748636 -1.44041538863661 1.4737393473242e-07 MirTarget -0.279681299541803 0.00307945280561783 NA NA NA hsa-miR-182-5p ASTN1 1.96601340710222 4.39326175603633e-09 -1.44041538863661 1.4737393473242e-07 miRNATAP -0.132558799496867 0.000805923994581534 NA NA NA hsa-miR-505-5p ASXL1 -0.768282569967001 1.14662846595407e-05 0.643009098868077 1.9064477563653e-16 MirTarget;miRNATAP -0.122951979550599 2.23559605244161e-08 NA NA NA hsa-miR-146b-5p ASXL2 0.419719546795449 0.0457375823220155 -0.286455507805721 0.180509718127653 miRanda -0.118861215134442 0.016567061451079 NA NA NA hsa-miR-15a-5p ASXL2 0.349521211668244 0.000770735998804736 -0.286455507805721 0.180509718127653 miRNAWalker2_validate -0.233421739509516 0.0206114889015848 NA NA NA hsa-miR-19b-3p ASXL2 0.601279551368824 0.00016685097085251 -0.286455507805721 0.180509718127653 MirTarget;miRNATAP -0.155648632221041 0.0166391444269372 NA NA NA hsa-miR-19b-3p ASXL3 0.601279551368824 0.00016685097085251 -2.68929167531641 1.94609933734597e-13 mirMAP -0.238143565877481 0.0380310999890062 NA NA NA hsa-miR-221-3p ASXL3 1.12244756358612 3.48370308238012e-13 -2.68929167531641 1.94609933734597e-13 miRNAWalker2_validate -0.946333249427835 2.29633026363543e-17 NA NA NA hsa-miR-21-5p ATAD2B 1.51084295924322 1.54551622173259e-34 -0.0635507129186372 0.479097593847395 miRNAWalker2_validate -0.136102764343005 2.65124149284912e-05 NA NA NA hsa-miR-34a-5p ATAD2B 1.03694231790865 5.74864019540594e-14 -0.0635507129186372 0.479097593847395 miRNATAP -0.134266115423146 1.04394495886564e-05 NA NA NA hsa-miR-215-5p ATAD5 -0.981544773246509 3.14452272477156e-05 1.62075220387752 5.7847793205543e-17 miRNAWalker2_validate -0.100819743890609 0.0146114442527728 NA NA NA hsa-miR-181a-5p ATE1 0.250113435902954 0.0551933249319293 -0.60221529485003 0.000898690867899849 mirMAP -0.174717185353719 0.0106525786073992 NA NA NA hsa-miR-181b-5p ATE1 0.488256489401108 0.00105321129419701 -0.60221529485003 0.000898690867899849 mirMAP -0.147580490607351 0.013161070971975 NA NA NA hsa-miR-20a-5p ATE1 0.854326758727003 5.04256669663285e-07 -0.60221529485003 0.000898690867899849 MirTarget -0.113270446654085 0.0284492547112625 NA NA NA hsa-miR-181a-5p ATF2 0.250113435902954 0.0551933249319293 -0.239353619837203 0.156190712870845 mirMAP;miRNATAP -0.1380691039949 0.0293886675894658 NA NA NA hsa-miR-21-5p ATF2 1.51084295924322 1.54551622173259e-34 -0.239353619837203 0.156190712870845 miRNAWalker2_validate -0.180342957288245 0.00335655702560994 NA NA NA hsa-miR-30b-5p ATF2 -0.54056186708617 2.44688760798341e-05 -0.239353619837203 0.156190712870845 mirMAP -0.223536389725042 0.000452180499441184 NA NA NA hsa-miR-15a-5p ATF6 0.349521211668244 0.000770735998804736 -0.0173962789843944 0.870548668789807 MirTarget -0.198309090789024 6.89817651846637e-05 NA NA NA hsa-miR-20b-5p ATF6 0.457668023910379 0.0285865211936156 -0.0173962789843944 0.870548668789807 mirMAP -0.101835331308615 3.50556925692092e-05 NA NA NA hsa-miR-181a-5p ATF7IP2 0.250113435902954 0.0551933249319293 -0.0938584832302367 0.508357029422166 miRNAWalker2_validate -0.147980304936348 0.00533469666928227 NA NA NA hsa-miR-181a-5p ATG10 0.250113435902954 0.0551933249319293 0.346641307647138 0.000519861295938401 miRNAWalker2_validate -0.228505724684997 5.90790179660372e-10 NA NA NA hsa-miR-30b-5p ATG12 -0.54056186708617 2.44688760798341e-05 0.220487935905037 0.0011232655371709 miRNAWalker2_validate;MirTarget -0.120775104208499 1.89952114211639e-06 NA NA NA hsa-miR-148a-3p ATG4D -0.748702855596996 3.93313343865641e-07 0.238017440609291 0.0358760810215454 MirTarget -0.177564676097827 1.28064680165471e-06 NA NA NA hsa-miR-455-5p ATL1 -0.270546034117157 0.0581320703577731 -0.0777056755852499 0.597838507551304 miRanda -0.108341355764028 0.0315814201323725 NA NA NA hsa-miR-221-3p ATL2 1.12244756358612 3.48370308238012e-13 -0.0961038265935708 0.239507878733616 miRNAWalker2_validate -0.101275516664927 4.55377195161898e-05 NA NA NA hsa-miR-19b-3p ATL3 0.601279551368824 0.00016685097085251 0.128948695025344 0.252547833929954 mirMAP -0.190643053669089 1.43870220709728e-08 NA NA NA hsa-miR-20a-5p ATL3 0.854326758727003 5.04256669663285e-07 0.128948695025344 0.252547833929954 miRNAWalker2_validate;MirTarget;miRNATAP -0.195920409876506 3.53974812154164e-10 NA NA NA hsa-miR-30b-5p ATL3 -0.54056186708617 2.44688760798341e-05 0.128948695025344 0.252547833929954 mirMAP -0.134255950257734 0.00159201294918061 NA NA NA hsa-miR-30c-5p ATL3 -0.432111642767632 0.000159764714931007 0.128948695025344 0.252547833929954 mirMAP -0.120894914778377 0.0116037697594965 NA NA NA hsa-miR-455-5p ATM -0.270546034117157 0.0581320703577731 -0.236058797850924 0.0173776926910908 miRanda -0.118715671502599 0.000450782297458542 NA NA NA hsa-miR-181a-5p ATMIN 0.250113435902954 0.0551933249319293 -0.371002750700502 5.51678829659403e-08 MirTarget -0.100333308589787 9.64429545824915e-05 NA NA NA hsa-miR-19b-3p ATMIN 0.601279551368824 0.00016685097085251 -0.371002750700502 5.51678829659403e-08 miRNAWalker2_validate -0.12110765778485 4.04203422240341e-09 NA NA NA hsa-miR-21-5p ATMIN 1.51084295924322 1.54551622173259e-34 -0.371002750700502 5.51678829659403e-08 miRNAWalker2_validate -0.12457794175966 5.46986481967043e-07 NA NA NA hsa-miR-19b-3p ATP10A 0.601279551368824 0.00016685097085251 0.423558174992768 0.129770428114507 MirTarget -0.295006415732775 0.000494844938136509 NA NA NA hsa-miR-146b-5p ATP10B 0.419719546795449 0.0457375823220155 -0.240054821493775 0.56639195970384 miRanda;miRNATAP -0.272899095563789 0.00487471547249301 NA NA NA hsa-miR-192-5p ATP10D -0.50188499512787 0.00344713341196035 -0.428042218506426 0.00646320508391909 miRNAWalker2_validate -0.125699577457152 0.00485942347009186 NA NA NA hsa-miR-148a-3p ATP11A -0.748702855596996 3.93313343865641e-07 0.189226775577938 0.159981440120013 MirTarget -0.168910484576989 0.000112028647058078 NA NA NA hsa-miR-21-5p ATP11B 1.51084295924322 1.54551622173259e-34 -0.346367156166827 0.00133271118765081 miRNAWalker2_validate -0.160915560238489 4.13017098875205e-05 NA NA NA hsa-miR-181a-5p ATP11C 0.250113435902954 0.0551933249319293 -1.59600836056671 1.48402272878339e-18 MirTarget;miRNATAP -0.555210921470812 6.86348240161472e-16 NA NA NA hsa-miR-181b-5p ATP11C 0.488256489401108 0.00105321129419701 -1.59600836056671 1.48402272878339e-18 MirTarget;miRNATAP -0.558459883888642 2.83012648582225e-21 NA NA NA hsa-miR-30b-5p ATP11C -0.54056186708617 2.44688760798341e-05 -1.59600836056671 1.48402272878339e-18 mirMAP -0.180025255735496 0.012315542740671 NA NA NA hsa-miR-455-5p ATP11C -0.270546034117157 0.0581320703577731 -1.59600836056671 1.48402272878339e-18 MirTarget;PITA;miRanda;miRNATAP -0.156869681366781 0.0157904260623033 NA NA NA hsa-miR-455-5p ATP13A2 -0.270546034117157 0.0581320703577731 0.916199024088815 1.08332996640179e-14 miRanda -0.177554964047665 2.00202134782471e-05 NA NA NA hsa-miR-15a-5p ATP13A3 0.349521211668244 0.000770735998804736 -0.599024874452984 3.11058586211371e-08 MirTarget;miRNATAP -0.166593062917535 0.00124966695909713 NA NA NA hsa-miR-99a-5p ATP1A1 -1.51481656384839 3.93230057259529e-14 0.440147433000591 0.000338942445963914 miRNAWalker2_validate -0.258085516674653 1.41857598469287e-20 NA NA NA hsa-miR-19b-3p ATP1A2 0.601279551368824 0.00016685097085251 0.511083548392086 0.111207698032313 MirTarget -0.331348973626515 0.000656494214391174 NA NA NA hsa-miR-20a-5p ATP1A2 0.854326758727003 5.04256669663285e-07 0.511083548392086 0.111207698032313 MirTarget;miRNATAP -0.320066988550342 0.000414612772175907 NA NA NA hsa-miR-455-3p ATP1B3 -1.3998033821095 5.72010709806871e-17 0.87044678799045 1.02682748957634e-07 PITA -0.29969210363009 4.90985258368557e-11 NA NA NA hsa-miR-455-3p ATP2A3 -1.3998033821095 5.72010709806871e-17 -0.318167561298274 0.122967244252675 mirMAP -0.291324599047481 3.5699737838777e-07 NA NA NA hsa-miR-29c-3p ATP2B1 -1.4367517608807 1.61767774905781e-21 -0.159908936957413 0.160796369285945 miRNATAP -0.222530345562326 8.57153406989403e-11 NA NA NA hsa-miR-21-5p ATP2B2 1.51084295924322 1.54551622173259e-34 -0.395324820466063 0.155178018219404 mirMAP -0.239511793571401 0.0183742080487048 NA NA NA hsa-miR-148a-3p ATP2B4 -0.748702855596996 3.93313343865641e-07 0.270147249141007 0.0673602510700001 MirTarget;miRNATAP -0.111342871164415 0.0211096551467596 NA NA NA hsa-miR-29c-3p ATP5G1 -1.4367517608807 1.61767774905781e-21 0.562901211655949 9.81793395077986e-06 MirTarget;miRNATAP -0.109277579996889 0.00568095869287874 NA NA NA hsa-miR-19b-3p ATP6V0E1 0.601279551368824 0.00016685097085251 0.233973293718859 0.0162516989332956 MirTarget -0.129062745681956 1.07552643552557e-05 NA NA NA hsa-miR-19b-3p ATP6V1B2 0.601279551368824 0.00016685097085251 -0.541453277558536 1.24353398203465e-09 MirTarget;miRNATAP -0.142260849898501 1.69332576817101e-07 NA NA NA hsa-miR-30b-5p ATP6V1B2 -0.54056186708617 2.44688760798341e-05 -0.541453277558536 1.24353398203465e-09 MirTarget -0.106308140650323 0.00193979438690064 NA NA NA hsa-miR-30c-5p ATP6V1C1 -0.432111642767632 0.000159764714931007 0.875287163526939 8.28405374117091e-15 miRNAWalker2_validate -0.262550730843759 8.2440141828803e-08 NA NA NA hsa-miR-148a-3p ATP7A -0.748702855596996 3.93313343865641e-07 0.251321858484382 0.0188455783467549 MirTarget;miRNATAP -0.117619391345964 0.000738334866649139 NA NA NA hsa-miR-455-5p ATP7A -0.270546034117157 0.0581320703577731 0.251321858484382 0.0188455783467549 miRanda -0.168623412696277 3.39896156301028e-06 NA NA NA hsa-miR-222-3p ATP7B 1.08574156066353 1.76407192348131e-11 -0.73149215480194 1.52550643042418e-05 miRNAWalker2_validate -0.142637406553656 0.00458846868993229 NA NA NA hsa-miR-30b-5p ATP8A1 -0.54056186708617 2.44688760798341e-05 -0.156454863558929 0.363663608776712 mirMAP -0.146212173994178 0.0250761948905681 NA NA NA hsa-miR-30b-5p ATP8B2 -0.54056186708617 2.44688760798341e-05 0.449375569488005 0.0172798987462009 miRNATAP -0.275014132532922 0.000115515967879705 NA NA NA hsa-miR-455-5p ATP8B3 -0.270546034117157 0.0581320703577731 0.807861432253821 0.000128740143543308 miRanda -0.347133458903967 1.46080408289727e-06 NA NA NA hsa-miR-192-5p ATP8B4 -0.50188499512787 0.00344713341196035 -1.1029205581874 1.42707460187988e-12 MirTarget -0.111997394935168 0.0136511900662527 NA NA NA hsa-miR-194-5p ATP8B4 -0.292530160992458 0.0996141384876663 -1.1029205581874 1.42707460187988e-12 MirTarget -0.136221929389087 0.00192113842833918 NA NA NA hsa-miR-505-5p ATP9A -0.768282569967001 1.14662846595407e-05 0.352728989524001 0.0303175660824993 mirMAP -0.142767245060118 0.00147318425039503 NA NA NA hsa-miR-21-5p ATRN 1.51084295924322 1.54551622173259e-34 0.11840720862332 0.341728688804806 miRNATAP -0.171300205806303 0.000147158588937355 NA NA NA hsa-miR-21-5p ATRNL1 1.51084295924322 1.54551622173259e-34 -2.27538406759707 4.17399658519262e-07 MirTarget -0.654556532527154 7.71322402871404e-05 NA NA NA hsa-miR-19b-3p ATRX 0.601279551368824 0.00016685097085251 -0.0677373088337614 0.487587480385071 MirTarget;miRNATAP -0.100054144922525 0.000675891893143838 NA NA NA hsa-miR-20a-5p ATRX 0.854326758727003 5.04256669663285e-07 -0.0677373088337614 0.487587480385071 mirMAP -0.125292083620034 4.43330227389919e-06 NA NA NA hsa-miR-21-5p ATRX 1.51084295924322 1.54551622173259e-34 -0.0677373088337614 0.487587480385071 miRNAWalker2_validate -0.103911084514062 0.00334972263417209 NA NA NA hsa-miR-455-5p ATRX -0.270546034117157 0.0581320703577731 -0.0677373088337614 0.487587480385071 miRNATAP -0.103515292163352 0.00183029359355249 NA NA NA hsa-miR-181a-5p ATXN1 0.250113435902954 0.0551933249319293 -0.14706644380352 0.164122106364193 miRNATAP -0.105683779662327 0.00754102467699507 NA NA NA hsa-miR-181b-5p ATXN1 0.488256489401108 0.00105321129419701 -0.14706644380352 0.164122106364193 miRNATAP -0.107973197961354 0.001670203706715 NA NA NA hsa-miR-30b-5p ATXN1 -0.54056186708617 2.44688760798341e-05 -0.14706644380352 0.164122106364193 mirMAP;miRNATAP -0.157000140289002 7.81218058966265e-05 NA NA NA hsa-miR-17-3p ATXN1L 0.410352776142368 0.00422200500748636 0.0891645419015585 0.389564952054527 miRNATAP -0.18382594287646 1.13280899113851e-07 NA NA NA hsa-miR-19b-3p ATXN1L 0.601279551368824 0.00016685097085251 0.0891645419015585 0.389564952054527 miRNATAP -0.134899422981934 1.4808840256852e-05 NA NA NA hsa-miR-20a-5p ATXN1L 0.854326758727003 5.04256669663285e-07 0.0891645419015585 0.389564952054527 miRNATAP -0.132523129952088 4.91843785893201e-06 NA NA NA hsa-miR-27b-3p ATXN2L -0.823491817819754 9.20935302746823e-14 0.611974248116638 1.12366931914732e-16 miRNATAP -0.181052371662931 2.32472693550681e-08 NA NA NA hsa-miR-21-5p ATXN3 1.51084295924322 1.54551622173259e-34 -0.293269047017985 0.000369461897713509 mirMAP -0.22240426764001 2.59427646320707e-14 NA NA NA hsa-miR-132-3p ATXN7 0.323796239695997 0.00272093067935091 -0.468011155586228 2.62773540153588e-07 MirTarget;miRNATAP -0.17306407427448 2.91873048206918e-05 NA NA NA hsa-miR-181b-5p ATXN7 0.488256489401108 0.00105321129419701 -0.468011155586228 2.62773540153588e-07 MirTarget -0.112981735252082 0.000154865012205089 NA NA NA hsa-miR-19b-3p ATXN7L1 0.601279551368824 0.00016685097085251 -0.241046795006661 0.0606470141841609 miRNAWalker2_validate;miRNATAP -0.25248956460461 3.65260913923109e-11 NA NA NA hsa-miR-148a-3p AURKB -0.748702855596996 3.93313343865641e-07 3.49342722879335 6.3137526890155e-40 miRNAWalker2_validate -0.529634555771283 1.73415568417495e-08 NA NA NA hsa-miR-21-5p AUTS2 1.51084295924322 1.54551622173259e-34 -1.19765271507382 9.8904416911024e-07 miRNAWalker2_validate -0.852360135392829 2.65946752125067e-23 NA NA NA hsa-miR-222-3p AUTS2 1.08574156066353 1.76407192348131e-11 -1.19765271507382 9.8904416911024e-07 miRNAWalker2_validate -0.354149804551788 9.99549312038688e-07 NA NA NA hsa-miR-181a-5p AVL9 0.250113435902954 0.0551933249319293 0.363254778951376 0.000323416937551397 MirTarget -0.112173010564899 0.0031614443689292 NA NA NA hsa-miR-30b-5p AVL9 -0.54056186708617 2.44688760798341e-05 0.363254778951376 0.000323416937551397 MirTarget;mirMAP -0.282874022911264 3.29898932674391e-14 NA NA NA hsa-miR-30c-5p AVL9 -0.432111642767632 0.000159764714931007 0.363254778951376 0.000323416937551397 MirTarget;mirMAP;miRNATAP -0.111191826050167 0.010053307421628 NA NA NA hsa-miR-34a-5p AXL 1.03694231790865 5.74864019540594e-14 -1.60150038405065 2.04803831000663e-19 miRNAWalker2_validate;miRTarBase;miRNATAP -0.372033493439335 3.25452435642409e-09 26667302;21814748;25895459 Negative feedback regulation of AXL by miR 34a modulates apoptosis in lung cancer cells; To clarify the role of miRNAs in this regulation loop approaches using bioinformatics and molecular techniques were applied revealing that miR-34a may target the 3' UTR of AXL mRNA to inhibit AXL expression; Therefore we propose that AXL is autoregulated by miR-34a in a feedback loop; this may provide a novel opportunity for developing AXL-targeted anticancer therapies;We identified human miR-34a expression as being >3-fold down from its median expression value across all cell lines in MDA-MB-231 cells and identified AXL as a putative mRNA target using multiple miRNA/target prediction algorithms; In reporter assays miR-34a binds to its putative target site within the AXL 3'UTR to inhibit luciferase expression; Finally we present an inverse correlative trend in miR-34a and AXL expression for both cell line and patient tumor samples;MiR 34a suppresses ovarian cancer proliferation and motility by targeting AXL; Overexpression of miR-34a led to the inhibition of AXL expression indicating that AXL is a target gene for miR-34a; Our data suggest that miR-34a may function as a tumor suppressor through repression of oncogenic AXL in ovarian cancer ;;motility lung cancer;breast cancer;ovarian cancer hsa-miR-30c-5p AZIN1 -0.432111642767632 0.000159764714931007 0.0896239818335802 0.429440769241766 mirMAP;miRNATAP -0.233118312187356 1.0168157598777e-06 NA NA NA hsa-miR-192-5p B3GALNT1 -0.50188499512787 0.00344713341196035 0.613905163989412 0.00100472420696999 miRNAWalker2_validate -0.416037686953911 5.40210677111514e-16 NA NA NA hsa-miR-215-5p B3GALNT1 -0.981544773246509 3.14452272477156e-05 0.613905163989412 0.00100472420696999 miRNAWalker2_validate -0.138908819906136 0.000282929353236825 NA NA NA hsa-miR-34a-5p B3GAT1 1.03694231790865 5.74864019540594e-14 -3.42907997928278 2.31569580096161e-14 MirTarget;miRNATAP -0.9091037495791 7.17525214677201e-09 NA NA NA hsa-miR-146b-5p B3GNT5 0.419719546795449 0.0457375823220155 0.793070163988416 0.000903109981778052 miRanda -0.147301747452803 0.00816148565229598 NA NA NA hsa-miR-192-5p B3GNT5 -0.50188499512787 0.00344713341196035 0.793070163988416 0.000903109981778052 miRNAWalker2_validate -0.18254791145049 0.00733849633082143 NA NA NA hsa-miR-29c-3p B3GNT5 -1.4367517608807 1.61767774905781e-21 0.793070163988416 0.000903109981778052 MirTarget -0.198079663130303 0.00736876982875174 NA NA NA hsa-miR-455-5p B4GALNT1 -0.270546034117157 0.0581320703577731 3.11045559383963 1.2344081776024e-16 miRanda -0.609692392232819 4.33050482252655e-06 NA NA NA hsa-miR-148a-3p B4GALT2 -0.748702855596996 3.93313343865641e-07 0.259508874283337 0.00786071208383262 miRNATAP -0.131729353475028 3.23468076819227e-05 NA NA NA hsa-miR-27b-3p B4GALT3 -0.823491817819754 9.20935302746823e-14 0.747431198851972 9.7665978149736e-18 MirTarget;miRNATAP -0.202875337431222 1.39346968332091e-07 NA NA NA hsa-miR-148a-3p B4GALT5 -0.748702855596996 3.93313343865641e-07 -0.523612200569853 3.66546987358603e-06 MirTarget;miRNATAP -0.326881094016732 4.65665310573306e-20 NA NA NA hsa-miR-409-3p BAAT -0.499649792570937 0.0526751181520117 -1.22078391735102 1.33400127612392e-05 PITA -0.198403890312202 0.000193065578632613 NA NA NA hsa-miR-21-5p BACE1 1.51084295924322 1.54551622173259e-34 -0.448698228025254 5.54093323862846e-07 mirMAP -0.285520961360197 1.62841748241726e-19 NA NA NA hsa-miR-15a-5p BACH2 0.349521211668244 0.000770735998804736 -1.98817818659277 2.20288210770245e-15 MirTarget;miRNATAP -0.364152683707579 0.00290573976340347 NA NA NA hsa-miR-19b-3p BACH2 0.601279551368824 0.00016685097085251 -1.98817818659277 2.20288210770245e-15 mirMAP -0.317234442662352 5.32787092934865e-05 NA NA NA hsa-miR-181a-5p BAG2 0.250113435902954 0.0551933249319293 0.547217615833161 0.000441980270190902 miRNAWalker2_validate -0.29557864691806 3.61974608037816e-07 NA NA NA hsa-miR-30b-5p BAG4 -0.54056186708617 2.44688760798341e-05 -0.821303974299604 1.73404066798239e-06 mirMAP -0.145590505863494 0.0272673650013317 NA NA NA hsa-miR-29c-3p BAK1 -1.4367517608807 1.61767774905781e-21 0.841822522200809 3.40565894621987e-10 miRNATAP -0.290105584106724 1.61335359476166e-12 NA NA NA hsa-miR-20b-5p BAMBI 0.457668023910379 0.0285865211936156 -0.221011903145495 0.426498976965747 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.160303232714705 0.0132291924628498 NA NA NA hsa-miR-455-5p BANK1 -0.270546034117157 0.0581320703577731 -0.620902030466746 0.0615119507198129 miRanda -0.246777339235111 0.0303890194810062 NA NA NA hsa-miR-30b-5p BARD1 -0.54056186708617 2.44688760798341e-05 0.550728358920836 0.0547327976779761 mirMAP -0.292991789045963 0.00706640673750558 NA NA NA hsa-miR-30b-5p BAZ1B -0.54056186708617 2.44688760798341e-05 0.137219966954402 0.0541828288120103 miRNAWalker2_validate -0.14429859144499 5.15280822292313e-08 NA NA NA hsa-miR-148a-3p BAZ2A -0.748702855596996 3.93313343865641e-07 0.461073155925693 4.28128289777929e-08 mirMAP;miRNATAP -0.15432037562048 1.83068832398087e-08 NA NA NA hsa-miR-27b-3p BAZ2A -0.823491817819754 9.20935302746823e-14 0.461073155925693 4.28128289777929e-08 miRNAWalker2_validate -0.109617976290385 0.00278390990591917 NA NA NA hsa-miR-99a-5p BAZ2A -1.51481656384839 3.93230057259529e-14 0.461073155925693 4.28128289777929e-08 MirTarget;miRNATAP -0.167618348946796 3.51583480343516e-18 NA NA NA hsa-miR-146b-5p BAZ2B 0.419719546795449 0.0457375823220155 -0.610687662126052 1.13780501941164e-07 miRanda -0.104232577749244 0.000108219521413453 NA NA NA hsa-miR-455-5p BAZ2B -0.270546034117157 0.0581320703577731 -0.610687662126052 1.13780501941164e-07 PITA;miRanda;miRNATAP -0.17353988948986 1.2162814362366e-05 NA NA NA hsa-miR-27b-3p BBC3 -0.823491817819754 9.20935302746823e-14 0.804667864310401 1.64815736901645e-10 miRNATAP -0.203869768027322 0.000220938302295931 NA NA NA hsa-miR-455-5p BBS2 -0.270546034117157 0.0581320703577731 0.00272998851387696 0.981777013157487 miRanda -0.113466027128579 0.00538771611995798 NA NA NA hsa-miR-192-5p BBS7 -0.50188499512787 0.00344713341196035 0.266690014901358 0.0901347389297157 miRNAWalker2_validate -0.167046709872477 0.000168465158422697 NA NA NA hsa-miR-17-3p BBX 0.410352776142368 0.00422200500748636 -0.0708140126861245 0.5432084569548 MirTarget;miRNATAP -0.25895559963039 1.93105130241677e-11 NA NA NA hsa-miR-192-3p BBX -0.6401165114007 0.000266272092403814 -0.0708140126861245 0.5432084569548 mirMAP -0.13047187495027 4.28365854179484e-05 NA NA NA hsa-miR-19b-3p BBX 0.601279551368824 0.00016685097085251 -0.0708140126861245 0.5432084569548 MirTarget;miRNATAP -0.17324307844589 6.90448807745182e-07 NA NA NA hsa-miR-20a-5p BBX 0.854326758727003 5.04256669663285e-07 -0.0708140126861245 0.5432084569548 MirTarget;miRNATAP -0.178232417606736 3.93270532841047e-08 NA NA NA hsa-miR-27b-3p BBX -0.823491817819754 9.20935302746823e-14 -0.0708140126861245 0.5432084569548 MirTarget;miRNATAP -0.114290335581857 0.0224693178035033 NA NA NA hsa-miR-27b-3p BCAN -0.823491817819754 9.20935302746823e-14 3.24529165288391 1.28551429438288e-16 miRNATAP -0.994538127054223 9.10432325558327e-09 NA NA NA hsa-miR-127-3p BCAS3 -1.0751374948053 2.19322892330221e-05 0.153911529370471 0.145042204046564 MirTarget;PITA;miRanda;miRNATAP -0.109259744781007 3.34044443181554e-08 NA NA NA hsa-miR-146b-5p BCAT2 0.419719546795449 0.0457375823220155 1.58400232037686 3.44418003749872e-20 miRNATAP -0.114894917256493 0.0060327957349417 NA NA NA hsa-miR-29c-3p BCL11A -1.4367517608807 1.61767774905781e-21 -0.11732578696554 0.708897593291357 miRNAWalker2_validate -0.204160155388779 0.0348906568191512 NA NA NA hsa-miR-34a-5p BCL11B 1.03694231790865 5.74864019540594e-14 -0.593505077674482 0.0136457116703732 miRNATAP -0.24810922418618 0.00271383562754772 NA NA NA hsa-miR-455-5p BCL11B -0.270546034117157 0.0581320703577731 -0.593505077674482 0.0136457116703732 miRanda -0.183298712254268 0.0266433554191956 NA NA NA hsa-miR-148a-3p BCL2 -0.748702855596996 3.93313343865641e-07 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate;miRTarBase -0.309765293468013 4.08540378699783e-10 21455217;23975374 MiR 148a promotes apoptosis by targeting Bcl 2 in colorectal cancer;MiR 148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl 2; Using western blot and luciferase activity assay CCKBR and Bcl-2 were identified as targets of miR-148a; Moreover we also found that the expression of Bcl-2 lacking in 3'UTR could abrogate the pro-apoptosis function of miR-148a ; colorectal cancer;pancreatic cancer hsa-miR-15a-5p BCL2 0.349521211668244 0.000770735998804736 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate;miRTarBase -0.167328042777219 0.021723913927065 25594541;26915294;18931683;25623762;22335947 MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 ;poor survival;;drug resistance; breast cancer;lung cancer;prostate cancer;colon cancer;breast cancer hsa-miR-192-5p BCL2 -0.50188499512787 0.00344713341196035 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate -0.343159016245154 5.19113742652329e-16 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192 drug resistance lung cancer hsa-miR-20a-5p BCL2 0.854326758727003 5.04256669663285e-07 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate;miRTarBase -0.309280985956287 4.00465486003896e-13 NA NA NA hsa-miR-34a-5p BCL2 1.03694231790865 5.74864019540594e-14 -0.34630447089245 0.0249701729768122 miRNAWalker2_validate;miRTarBase -0.113194223983593 0.0332892113643548 23862748;24565525;23155233;24444609;20687223;22623155;24988056;18803879;19714243;25053345;20433755;21399894;22964582 MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression;In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2 ;drug resistance;;poor survival;drug resistance;;;poor survival;differentiation;poor survival;drug resistance;;; liver cancer;breast cancer;glioblastoma;lung squamous cell cancer;prostate cancer;breast cancer;gastric cancer;gastric cancer;pancreatic cancer;prostate cancer;colon cancer;breast cancer;lung cancer hsa-miR-455-5p BCL2 -0.270546034117157 0.0581320703577731 -0.34630447089245 0.0249701729768122 mirMAP -0.187920872762485 0.00036775461526632 NA NA NA hsa-miR-15a-5p BCL2L13 0.349521211668244 0.000770735998804736 -0.455591541067221 6.40583739182602e-11 MirTarget -0.100758461132831 0.00253830025591163 NA NA NA hsa-miR-30e-5p BCL2L15 -0.627815042856657 3.02205690184908e-10 0.824812528570962 0.00091588054533015 MirTarget -0.367247368773783 0.00235116022046518 NA NA NA hsa-miR-15a-5p BCL2L2 0.349521211668244 0.000770735998804736 0.146896981458628 0.089790398449786 MirTarget;miRNATAP -0.10982496188434 0.00686242554464801 25874488 MicroRNA 15a induces cell apoptosis and inhibits metastasis by targeting BCL2L2 in non small cell lung cancer; Furthermore we identified that BCL2L2 was a target of miR-15a and negatively regulated by miR-15a at the translational level; miR-15a acts as a tumor suppressor in NSCLC by directly targeting BCL2L2 and may serve as a potential diagnostic biomarker and therapeutic target for NSCLC metastasis lung squamous cell cancer hsa-miR-19b-3p BCL3 0.601279551368824 0.00016685097085251 -0.765464597973532 1.56158576079728e-07 miRNATAP -0.159629714533915 0.000366703928083243 27572553 Notably miR-19b inversely regulated B-cell CLL/lymphoma 3 BCL3 abundance in gastric cancer cells; BCL3 was identified as a direct target of miR-19b using luciferase reporter assays; Moreover BCL3 knockdown abolished the effects of miR-19b knockdown on gastric cancer cells lymphoma hsa-miR-181a-5p BCL6 0.250113435902954 0.0551933249319293 -0.381728718096561 0.00304721869179574 miRNATAP -0.166314085346097 0.000578237148046448 NA NA NA hsa-miR-181b-5p BCL6 0.488256489401108 0.00105321129419701 -0.381728718096561 0.00304721869179574 miRNATAP -0.19439898428624 3.29254065682167e-06 NA NA NA hsa-miR-21-5p BCL6 1.51084295924322 1.54551622173259e-34 -0.381728718096561 0.00304721869179574 miRNAWalker2_validate -0.188140069576131 5.95723698698918e-05 NA NA NA hsa-miR-30c-5p BCL9 -0.432111642767632 0.000159764714931007 1.17619476675548 1.43287619580645e-16 miRNATAP -0.1360813912942 0.030989631473172 26998113 BCL9 a coactivator for Wnt/β catenin transcription is targeted by miR 30c and is associated with prostate cancer progression; The present study demonstrated that miR-30c serves as a key negative regulator targeting BCL9 transcription in PCa cells; After substantiating this finding by patient sample analysis BCL9 expression or activity was observed to be closely correlated with PCa biochemical recurrence BCR and disease progression whereas it was inversely associated with miR-30c; Furthermore overexpression of BCL9 in PCa acted cooperatively with miR-30c low expression to predict earlier BCR in PCa; Furthermore the combined analysis of miR-30c and BCL9 may be valuable tool for prediction of BCR in PCa patients following radical prostatectomy progression;recurrence prostate cancer hsa-miR-148a-3p BCL9L -0.748702855596996 3.93313343865641e-07 0.488893976862282 7.48836967061567e-05 mirMAP -0.252714926187226 2.14292604768469e-10 NA NA NA hsa-miR-192-3p BCL9L -0.6401165114007 0.000266272092403814 0.488893976862282 7.48836967061567e-05 mirMAP -0.16574024700074 1.07038242772309e-06 NA NA NA hsa-miR-29c-3p BCORL1 -1.4367517608807 1.61767774905781e-21 0.512301558321965 0.000319198853421924 miRNATAP -0.32638081874734 2.16185974824924e-14 NA NA NA hsa-miR-21-5p BDH2 1.51084295924322 1.54551622173259e-34 -1.59270294219311 1.02319078238481e-23 miRNAWalker2_validate -0.56515861454063 2.8021537723332e-22 NA NA NA hsa-miR-192-3p BDNF -0.6401165114007 0.000266272092403814 0.0509404608382562 0.831886089502745 MirTarget;miRNATAP -0.316265894039516 1.40962674503077e-06 NA NA NA hsa-miR-30b-5p BECN1 -0.54056186708617 2.44688760798341e-05 0.0722018142800431 0.271844685660497 MirTarget -0.114072198615357 3.15029869857669e-06 26209295 Fluorouracil induces autophagy related gastric carcinoma cell death through Beclin 1 upregulation by miR 30 suppression; Further microRNA miR-30 was found to be regulated by 5-FU and bioinformatics analysis showed that miR-30 targeted the 3'-UTR of Beclin-1 to inhibit its translation; Together these data suggest that 5-FU may suppress miR-30 to upregulate Beclin-1 to induce autophagic cell death and cell proliferation arrest in GC cells gastric cancer hsa-miR-27b-3p BEND3 -0.823491817819754 9.20935302746823e-14 1.01774373383669 5.6745626823253e-12 miRNATAP -0.128868398452988 0.048950430621724 NA NA NA hsa-miR-30c-5p BEND3 -0.432111642767632 0.000159764714931007 1.01774373383669 5.6745626823253e-12 mirMAP;miRNATAP -0.181131950435372 0.00502613270306621 NA NA NA hsa-miR-30e-5p BEND3 -0.627815042856657 3.02205690184908e-10 1.01774373383669 5.6745626823253e-12 mirMAP -0.350491373273906 1.37003045032463e-06 NA NA NA hsa-miR-27b-3p BEST1 -0.823491817819754 9.20935302746823e-14 0.397419440138162 0.0452322711716492 MirTarget -0.248426334905831 0.00366561485110677 NA NA NA hsa-miR-146b-5p BHLHB9 0.419719546795449 0.0457375823220155 0.0209214260736654 0.894142398165846 miRanda -0.142680166929973 8.04300609474563e-05 NA NA NA hsa-miR-192-5p BHLHE22 -0.50188499512787 0.00344713341196035 -1.8780713907135 1.9887576917688e-08 MirTarget;miRNATAP -0.517404829760929 5.59541756379103e-08 NA NA NA hsa-miR-181b-5p BHLHE40 0.488256489401108 0.00105321129419701 -1.42834263281938 2.56737972441221e-18 MirTarget;miRNATAP -0.133375202341344 0.0168411811221064 NA NA NA hsa-miR-148a-3p BHLHE41 -0.748702855596996 3.93313343865641e-07 -0.40186061667449 0.159058094290555 MirTarget -0.822231025139073 2.60286252642047e-20 NA NA NA hsa-miR-20a-5p BHLHE41 0.854326758727003 5.04256669663285e-07 -0.40186061667449 0.159058094290555 miRNATAP -0.42796250951698 8.21856768874901e-08 NA NA NA hsa-miR-192-5p BICD1 -0.50188499512787 0.00344713341196035 0.798278862498021 0.000395688075323181 miRNAWalker2_validate -0.457941514727123 2.37513682930315e-13 NA NA NA hsa-miR-30e-5p BICD1 -0.627815042856657 3.02205690184908e-10 0.798278862498021 0.000395688075323181 mirMAP -0.377419380442103 0.000550838028796386 NA NA NA hsa-miR-194-5p BICD2 -0.292530160992458 0.0996141384876663 -0.0560120973992033 0.436805254709591 miRNATAP -0.124428982066392 9.90908883139318e-11 NA NA NA hsa-miR-30c-5p BIRC5 -0.432111642767632 0.000159764714931007 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate -0.45333717178008 0.00191124919706276 NA NA NA hsa-miR-34a-5p BIRC6 1.03694231790865 5.74864019540594e-14 -0.304492499139085 0.00104386727172646 miRNAWalker2_validate -0.132295458335101 3.09058139395423e-05 NA NA NA hsa-miR-132-3p BLCAP 0.323796239695997 0.00272093067935091 -0.40718265160047 0.000208400422206877 MirTarget -0.317410442194746 9.16430079002883e-11 NA NA NA hsa-miR-19b-3p BLCAP 0.601279551368824 0.00016685097085251 -0.40718265160047 0.000208400422206877 miRNAWalker2_validate;MirTarget;miRNATAP -0.14027838628184 2.50623576851436e-05 NA NA NA hsa-miR-192-5p BLM -0.50188499512787 0.00344713341196035 2.50912465937782 1.07866310951508e-24 miRNAWalker2_validate -0.204767671899931 0.00540874533709116 NA NA NA hsa-miR-29c-3p BLMH -1.4367517608807 1.61767774905781e-21 0.0965690311449263 0.630257792052704 MirTarget;miRNATAP -0.368183993696558 1.2076310146292e-09 NA NA NA hsa-miR-505-5p BLOC1S3 -0.768282569967001 1.14662846595407e-05 0.941668551077184 4.10662446414623e-25 MirTarget -0.127351388826853 1.3394176915692e-06 NA NA NA hsa-miR-455-5p BLZF1 -0.270546034117157 0.0581320703577731 0.462039092845203 5.39780961924684e-06 miRanda -0.135895263540309 9.83272661561069e-05 NA NA NA hsa-miR-148a-3p BMF -0.748702855596996 3.93313343865641e-07 0.478799554865222 0.0182321819658814 mirMAP -0.313554651598086 1.85985160484412e-06 NA NA NA hsa-miR-29c-3p BMF -1.4367517608807 1.61767774905781e-21 0.478799554865222 0.0182321819658814 MirTarget;miRNATAP -0.50113832994507 9.20920606136018e-17 NA NA NA hsa-miR-192-5p BMP2K -0.50188499512787 0.00344713341196035 -0.818475794333253 1.85957627715201e-10 miRNAWalker2_validate -0.161167657397344 1.27324072367936e-05 NA NA NA hsa-miR-21-5p BMP2K 1.51084295924322 1.54551622173259e-34 -0.818475794333253 1.85957627715201e-10 mirMAP -0.123948593677391 0.00963381579892384 NA NA NA hsa-miR-30e-5p BMP7 -0.627815042856657 3.02205690184908e-10 0.826802462156244 0.0488671273441991 mirMAP -0.577684399384162 0.00443944182643628 NA NA NA hsa-miR-34a-5p BMP7 1.03694231790865 5.74864019540594e-14 0.826802462156244 0.0488671273441991 miRNAWalker2_validate -0.454356184389064 0.00161959499114198 NA NA NA hsa-miR-146b-5p BMP8A 0.419719546795449 0.0457375823220155 1.39179535627051 2.07768362972566e-10 miRanda -0.120676087827195 0.020239063262763 NA NA NA hsa-miR-455-5p BMP8A -0.270546034117157 0.0581320703577731 1.39179535627051 2.07768362972566e-10 MirTarget;miRanda -0.220675062526455 0.00398165917143642 NA NA NA hsa-miR-182-5p BMPER 1.96601340710222 4.39326175603633e-09 -6.22874722091532 2.3884684161097e-65 MirTarget -0.20804183321291 0.000654195359441107 NA NA NA hsa-miR-19b-3p BMPER 0.601279551368824 0.00016685097085251 -6.22874722091532 2.3884684161097e-65 miRNATAP -0.564082565774472 1.33306096268653e-05 NA NA NA hsa-miR-224-3p BMPER 1.40770116795301 1.31426607144612e-08 -6.22874722091532 2.3884684161097e-65 MirTarget -0.426200332999618 2.94944028648592e-07 NA NA NA hsa-miR-19b-3p BMPR2 0.601279551368824 0.00016685097085251 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.213406658258386 2.11523139256821e-11 NA NA NA hsa-miR-20a-5p BMPR2 0.854326758727003 5.04256669663285e-07 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.240712956475078 2.24570589605185e-16 NA NA NA hsa-miR-21-5p BMPR2 1.51084295924322 1.54551622173259e-34 -0.735692104466334 2.00485450351153e-12 miRNAWalker2_validate;miRTarBase;MirTarget -0.284574090091544 7.19521500454622e-14 NA NA NA hsa-miR-455-5p BMPR2 -0.270546034117157 0.0581320703577731 -0.735692104466334 2.00485450351153e-12 PITA -0.128605088499673 0.000444129926379739 NA NA NA hsa-miR-15a-5p BMX 0.349521211668244 0.000770735998804736 -1.54653358558291 4.80650063650888e-09 MirTarget;miRNATAP -0.262068568564272 0.0391848016217151 NA NA NA hsa-miR-19b-3p BNC2 0.601279551368824 0.00016685097085251 -0.388487485712339 0.0897285209798168 MirTarget;miRNATAP -0.302996780086806 1.14862147203179e-05 NA NA NA hsa-miR-20a-5p BNC2 0.854326758727003 5.04256669663285e-07 -0.388487485712339 0.0897285209798168 miRNATAP -0.360035085736884 1.7918056419551e-08 NA NA NA hsa-miR-30e-5p BNC2 -0.627815042856657 3.02205690184908e-10 -0.388487485712339 0.0897285209798168 mirMAP -0.28509932599661 0.0100278382826645 NA NA NA hsa-miR-455-5p BNC2 -0.270546034117157 0.0581320703577731 -0.388487485712339 0.0897285209798168 miRanda -0.516474824705047 1.60786340669443e-11 NA NA NA hsa-miR-132-3p BNIP2 0.323796239695997 0.00272093067935091 -0.737340242844743 1.28341402865274e-20 miRNAWalker2_validate;MirTarget;miRNATAP -0.105207033074629 0.00507258972562642 NA NA NA hsa-miR-221-3p BNIP3 1.12244756358612 3.48370308238012e-13 -0.56708142845002 7.502879446291e-06 miRNAWalker2_validate -0.191683138524634 8.17069300196437e-07 NA NA NA hsa-miR-20a-5p BNIP3L 0.854326758727003 5.04256669663285e-07 -0.67007493110919 3.59838811073751e-10 MirTarget -0.198826101982103 4.67122584810606e-11 NA NA NA hsa-miR-221-3p BNIP3L 1.12244756358612 3.48370308238012e-13 -0.67007493110919 3.59838811073751e-10 miRNAWalker2_validate;miRTarBase -0.123031734398075 0.000226666656146561 NA NA NA hsa-miR-127-3p BOLA1 -1.0751374948053 2.19322892330221e-05 0.719718064594598 2.65024614986922e-10 miRanda -0.14120931932097 7.3708228755075e-11 NA NA NA hsa-miR-15a-5p BPTF 0.349521211668244 0.000770735998804736 0.12229687542247 0.206763945594438 miRNATAP -0.125821382767703 0.00563207024026148 NA NA NA hsa-miR-21-5p BRD1 1.51084295924322 1.54551622173259e-34 -0.222201860531052 0.011729440795329 MirTarget -0.100100275047052 0.00179805204947613 NA NA NA hsa-miR-29c-3p BRD3 -1.4367517608807 1.61767774905781e-21 0.205193972794628 0.0635043351898928 miRNATAP -0.169778116381103 4.35986317073618e-07 NA NA NA hsa-miR-455-5p BRE -0.270546034117157 0.0581320703577731 0.406505170752868 1.85293467178474e-06 miRanda -0.144899167712805 6.41600775925176e-07 NA NA NA hsa-miR-127-3p BRIP1 -1.0751374948053 2.19322892330221e-05 1.05558710574343 4.98525951061219e-05 miRanda -0.10851863800366 0.0302003256325907 NA NA NA hsa-miR-17-3p BRMS1L 0.410352776142368 0.00422200500748636 -0.377131758878461 1.81736829428481e-06 MirTarget -0.12561977371442 2.79094180698316e-06 NA NA NA hsa-miR-27b-3p BRSK1 -0.823491817819754 9.20935302746823e-14 1.81105177787136 9.45669167882099e-16 MirTarget;miRNATAP -0.597414449434798 1.59945390904914e-09 NA NA NA hsa-miR-15a-5p BRSK2 0.349521211668244 0.000770735998804736 1.39040613056321 0.000399787455740901 mirMAP -0.45218290660546 0.0152541072260419 NA NA NA hsa-miR-27b-3p BRSK2 -0.823491817819754 9.20935302746823e-14 1.39040613056321 0.000399787455740901 MirTarget;miRNATAP -0.678037735755323 6.27192410895021e-05 NA NA NA hsa-miR-132-3p BRWD1 0.323796239695997 0.00272093067935091 -0.472319203635839 2.18876455365102e-07 MirTarget -0.298651488341936 1.98074533537466e-13 NA NA NA hsa-miR-181a-5p BRWD1 0.250113435902954 0.0551933249319293 -0.472319203635839 2.18876455365102e-07 MirTarget -0.137356717143762 6.50718262952356e-05 NA NA NA hsa-miR-181b-5p BRWD1 0.488256489401108 0.00105321129419701 -0.472319203635839 2.18876455365102e-07 MirTarget -0.154688424650566 1.94268680460216e-07 NA NA NA hsa-miR-221-3p BRWD1 1.12244756358612 3.48370308238012e-13 -0.472319203635839 2.18876455365102e-07 MirTarget -0.143440565347809 3.0138189803526e-07 NA NA NA hsa-miR-222-3p BRWD1 1.08574156066353 1.76407192348131e-11 -0.472319203635839 2.18876455365102e-07 MirTarget -0.135897194617538 4.28493445180945e-07 NA NA NA hsa-miR-29c-3p BRWD3 -1.4367517608807 1.61767774905781e-21 0.097389343514537 0.536703137535803 MirTarget;miRNATAP -0.11603133056838 0.0166456688179947 NA NA NA hsa-miR-30b-5p BRWD3 -0.54056186708617 2.44688760798341e-05 0.097389343514537 0.536703137535803 MirTarget -0.268826099983959 5.50080529957108e-06 NA NA NA hsa-miR-15a-5p BSDC1 0.349521211668244 0.000770735998804736 -0.680073983677536 4.27542041261853e-16 MirTarget -0.105129990128068 0.00988174658198716 NA NA NA hsa-miR-27b-3p BSN -0.823491817819754 9.20935302746823e-14 0.943588815475765 2.35563209281755e-05 mirMAP -0.19100696376582 0.0494604809951741 NA NA NA hsa-miR-132-3p BTAF1 0.323796239695997 0.00272093067935091 0.0259637569428586 0.839471752480506 MirTarget -0.180073789718552 0.00185695848727046 NA NA NA hsa-miR-455-5p BTBD1 -0.270546034117157 0.0581320703577731 -0.312261515812403 1.1031027279009e-05 miRanda -0.165102225769854 4.18376222721723e-12 NA NA NA hsa-miR-148a-3p BTBD10 -0.748702855596996 3.93313343865641e-07 0.283901647603299 2.32887164783357e-05 MirTarget;miRNATAP -0.173605296764223 2.61734389373406e-16 NA NA NA hsa-miR-192-3p BTBD10 -0.6401165114007 0.000266272092403814 0.283901647603299 2.32887164783357e-05 miRNATAP -0.140213695136333 6.46313482277187e-15 NA NA NA hsa-miR-455-3p BTBD10 -1.3998033821095 5.72010709806871e-17 0.283901647603299 2.32887164783357e-05 MirTarget -0.11186088672698 1.59370412680898e-09 NA NA NA hsa-miR-148a-3p BTBD3 -0.748702855596996 3.93313343865641e-07 0.299640501202244 0.00861061458292312 miRNAWalker2_validate;miRNATAP -0.165809468768616 7.41091066221071e-06 NA NA NA hsa-miR-192-5p BTF3L4 -0.50188499512787 0.00344713341196035 -0.100360507081779 0.172074476918219 miRNAWalker2_validate -0.122110499991506 1.94924301637388e-09 NA NA NA hsa-miR-455-3p BTG2 -1.3998033821095 5.72010709806871e-17 -0.630184582086319 0.000279781600661663 MirTarget;PITA;miRNATAP -0.124318090450866 0.0111437481276323 NA NA NA hsa-miR-455-3p BTN2A2 -1.3998033821095 5.72010709806871e-17 0.742221529578643 1.20884513092496e-09 mirMAP -0.12461608540129 0.000341264545280505 NA NA NA hsa-miR-20a-5p BTN3A1 0.854326758727003 5.04256669663285e-07 0.334169263969577 0.0147772190819653 miRNAWalker2_validate -0.20556452967795 8.45055210241498e-08 NA NA NA hsa-miR-192-5p BUB1B -0.50188499512787 0.00344713341196035 3.85682830100864 2.02974032557381e-43 miRNAWalker2_validate -0.221905021279395 0.0119217114033508 NA NA NA hsa-miR-215-5p BUB1B -0.981544773246509 3.14452272477156e-05 3.85682830100864 2.02974032557381e-43 miRNAWalker2_validate -0.164346842914509 0.0099257038268172 NA NA NA hsa-miR-15a-5p BVES 0.349521211668244 0.000770735998804736 -0.598065561585224 0.0036533054063061 MirTarget -0.300055226909297 0.00200602036576031 NA NA NA hsa-miR-192-5p BVES -0.50188499512787 0.00344713341196035 -0.598065561585224 0.0036533054063061 mirMAP -0.287669978983438 6.8159832940245e-07 NA NA NA hsa-miR-30c-5p C10orf76 -0.432111642767632 0.000159764714931007 0.00181010223953315 0.976632752112705 miRNATAP -0.134716023932163 1.65728667450761e-07 NA NA NA hsa-miR-34a-5p C10orf91 1.03694231790865 5.74864019540594e-14 0.694381906552283 0.023571481656619 mirMAP -0.288981320059523 0.0061724002203365 NA NA NA hsa-miR-192-3p C14orf132 -0.6401165114007 0.000266272092403814 -0.329646110513596 0.294128601475655 mirMAP -0.364728121584228 2.32772392665246e-05 NA NA NA hsa-miR-17-3p C15orf52 0.410352776142368 0.00422200500748636 0.415956597921443 0.0643992937880854 mirMAP -0.159313146593187 0.0376141384664059 NA NA NA hsa-miR-192-3p C15orf52 -0.6401165114007 0.000266272092403814 0.415956597921443 0.0643992937880854 mirMAP -0.383266014498291 3.28130411448557e-10 NA NA NA hsa-miR-192-5p C15orf52 -0.50188499512787 0.00344713341196035 0.415956597921443 0.0643992937880854 mirMAP -0.435287965298841 2.66460522560021e-12 NA NA NA hsa-miR-19b-3p C16orf52 0.601279551368824 0.00016685097085251 -0.498924156279034 2.0232126667381e-06 miRNATAP -0.179106178838184 1.65284427760643e-08 NA NA NA hsa-miR-20a-5p C16orf52 0.854326758727003 5.04256669663285e-07 -0.498924156279034 2.0232126667381e-06 miRNATAP -0.177480833579238 1.82259009146111e-09 NA NA NA hsa-miR-21-5p C16orf52 1.51084295924322 1.54551622173259e-34 -0.498924156279034 2.0232126667381e-06 miRNATAP -0.288699972211743 1.38137136690354e-14 NA NA NA hsa-miR-182-5p C16orf70 1.96601340710222 4.39326175603633e-09 -0.765094694813145 5.94169478628678e-11 miRNATAP -0.112919215699075 1.15907610968691e-11 NA NA NA hsa-miR-19b-3p C16orf70 0.601279551368824 0.00016685097085251 -0.765094694813145 5.94169478628678e-11 miRNATAP -0.117690275627983 0.00115866100388946 NA NA NA hsa-miR-20a-5p C16orf70 0.854326758727003 5.04256669663285e-07 -0.765094694813145 5.94169478628678e-11 miRNATAP -0.11381929252027 0.000750228065073346 NA NA NA hsa-miR-181a-5p C16orf87 0.250113435902954 0.0551933249319293 -0.852328170796381 9.88960275881957e-13 miRNATAP -0.238518298402568 1.60346671070869e-07 NA NA NA hsa-miR-181b-5p C16orf87 0.488256489401108 0.00105321129419701 -0.852328170796381 9.88960275881957e-13 miRNATAP -0.226491575098053 9.52186233186709e-09 NA NA NA hsa-miR-181b-5p C17orf51 0.488256489401108 0.00105321129419701 -0.666308125870991 0.001643343913341 mirMAP -0.150440087660372 0.0304162372972828 NA NA NA hsa-miR-192-3p C17orf51 -0.6401165114007 0.000266272092403814 -0.666308125870991 0.001643343913341 mirMAP -0.154466029684716 0.00853751683708669 NA NA NA hsa-miR-29c-3p C19orf47 -1.4367517608807 1.61767774905781e-21 0.211259527483663 0.00974809011389087 mirMAP -0.12002781333979 1.37234910264915e-06 NA NA NA hsa-miR-30c-5p C1QBP -0.432111642767632 0.000159764714931007 -0.204932778719307 0.0480902106906643 miRNAWalker2_validate -0.176989823205865 5.43127098179706e-05 NA NA NA hsa-miR-15a-5p C1QL3 0.349521211668244 0.000770735998804736 -0.930256852131001 0.00121058879117188 miRNATAP -0.409541773674128 0.00259002341417447 NA NA NA hsa-miR-215-5p C1QTNF3 -0.981544773246509 3.14452272477156e-05 1.5060238064027 1.54156123235381e-06 miRNAWalker2_validate -0.374496064520076 4.73798540716409e-09 NA NA NA hsa-miR-29c-3p C1QTNF6 -1.4367517608807 1.61767774905781e-21 0.940249767401212 1.97916332580251e-10 miRNATAP -0.366031680292137 3.40233741443302e-16 NA NA NA hsa-miR-148a-3p C1orf116 -0.748702855596996 3.93313343865641e-07 -1.07293974225301 0.00530380557251411 mirMAP -0.613864425757337 8.93655915053795e-07 NA NA NA hsa-miR-34a-5p C1orf116 1.03694231790865 5.74864019540594e-14 -1.07293974225301 0.00530380557251411 miRNATAP -0.465421712461142 0.000432967916478942 NA NA NA hsa-miR-192-3p C1orf198 -0.6401165114007 0.000266272092403814 1.07342856228451 2.84182091357201e-15 mirMAP -0.215362086220042 1.85864105911225e-08 NA NA NA hsa-miR-132-3p C1orf21 0.323796239695997 0.00272093067935091 -0.747097178874137 0.000448927531443378 mirMAP -0.268612854611613 0.00565104184932449 NA NA NA hsa-miR-146a-5p C1orf21 -0.742958238440575 0.000765983177482633 -0.747097178874137 0.000448927531443378 mirMAP -0.120458389271852 0.0104187586736454 NA NA NA hsa-miR-146b-5p C1orf21 0.419719546795449 0.0457375823220155 -0.747097178874137 0.000448927531443378 mirMAP -0.104748630304027 0.035123028606609 NA NA NA hsa-miR-15a-5p C1orf21 0.349521211668244 0.000770735998804736 -0.747097178874137 0.000448927531443378 mirMAP;miRNATAP -0.243644680931681 0.0157980156491802 NA NA NA hsa-miR-17-3p C1orf21 0.410352776142368 0.00422200500748636 -0.747097178874137 0.000448927531443378 mirMAP -0.331449530419349 4.39160771604771e-06 NA NA NA hsa-miR-409-3p C1orf21 -0.499649792570937 0.0526751181520117 -0.747097178874137 0.000448927531443378 PITA;mirMAP -0.12531422032394 0.00189397286147246 NA NA NA hsa-miR-21-5p C1orf226 1.51084295924322 1.54551622173259e-34 0.294177134343668 0.072174506797414 mirMAP -0.125474880304265 0.0358426145551995 NA NA NA hsa-miR-17-3p C1orf64 0.410352776142368 0.00422200500748636 1.35472441194989 0.00602555619755745 mirMAP -0.348714037823236 0.0385847351268817 NA NA NA hsa-miR-192-3p C20orf194 -0.6401165114007 0.000266272092403814 0.238037680827578 0.0793767985288294 mirMAP -0.284150667959588 4.67032019371791e-15 NA NA NA hsa-miR-27b-3p C20orf194 -0.823491817819754 9.20935302746823e-14 0.238037680827578 0.0793767985288294 miRNATAP -0.178709226168511 0.00218432834509195 NA NA NA hsa-miR-455-5p C20orf194 -0.270546034117157 0.0581320703577731 0.238037680827578 0.0793767985288294 miRNATAP -0.218159803177537 2.10313531751395e-06 NA NA NA hsa-miR-27b-3p C22orf29 -0.823491817819754 9.20935302746823e-14 1.09019898263552 1.10984149710713e-27 mirMAP -0.121191961464524 0.00840991427235954 NA NA NA hsa-miR-19b-3p C2CD2 0.601279551368824 0.00016685097085251 0.0379059338335348 0.761740129175128 mirMAP -0.150679436152959 6.30759610545332e-05 NA NA NA hsa-miR-20a-5p C2CD2 0.854326758727003 5.04256669663285e-07 0.0379059338335348 0.761740129175128 MirTarget;miRNATAP -0.190500339666864 4.53382021622743e-08 NA NA NA hsa-miR-27b-3p C2CD2 -0.823491817819754 9.20935302746823e-14 0.0379059338335348 0.761740129175128 MirTarget -0.159915185214851 0.00287159314916706 NA NA NA hsa-miR-192-5p C2CD4A -0.50188499512787 0.00344713341196035 0.228212273121767 0.594894906410024 mirMAP -0.27344393042256 0.0246760168528404 NA NA NA hsa-miR-181a-5p C2orf69 0.250113435902954 0.0551933249319293 -0.190645957879418 0.0407940707859741 miRNATAP -0.272280254168303 6.61125660188904e-16 NA NA NA hsa-miR-181b-5p C2orf69 0.488256489401108 0.00105321129419701 -0.190645957879418 0.0407940707859741 miRNATAP -0.24937263137335 1.30663265356443e-17 NA NA NA hsa-miR-132-3p C3orf58 0.323796239695997 0.00272093067935091 -0.745640119422575 5.4670302246289e-05 miRNATAP -0.322413996146639 0.000125914843767595 NA NA NA hsa-miR-30b-5p C4orf46 -0.54056186708617 2.44688760798341e-05 1.13505835779632 6.16051985241999e-22 mirMAP -0.11108078890697 0.0183072708482138 NA NA NA hsa-miR-455-5p C5AR1 -0.270546034117157 0.0581320703577731 -1.16551867305588 2.01005534320675e-11 miRanda -0.34299911167895 1.14140662855083e-08 NA NA NA hsa-miR-148a-3p C5orf30 -0.748702855596996 3.93313343865641e-07 0.905488139382461 0.000488976635207195 miRNATAP -0.740736014753206 1.17959742896383e-19 NA NA NA hsa-miR-181a-5p C5orf51 0.250113435902954 0.0551933249319293 0.245646842072128 0.00284809732816773 mirMAP -0.142228616286967 3.36247873344053e-06 NA NA NA hsa-miR-181b-5p C5orf51 0.488256489401108 0.00105321129419701 0.245646842072128 0.00284809732816773 mirMAP -0.114139238551824 1.87700233679776e-05 NA NA NA hsa-miR-132-3p C6orf106 0.323796239695997 0.00272093067935091 0.17028043460772 0.0607652379703991 miRNATAP -0.204834135678573 4.53575107583728e-07 NA NA NA hsa-miR-30e-5p C6orf132 -0.627815042856657 3.02205690184908e-10 -0.931284026636831 0.0129966976285094 mirMAP -0.435314180433253 0.0166807480512436 NA NA NA hsa-miR-192-5p C6orf223 -0.50188499512787 0.00344713341196035 0.669280204465648 0.189250898670159 mirMAP -0.401154733255861 0.00550023094876772 NA NA NA hsa-miR-30c-5p C7orf43 -0.432111642767632 0.000159764714931007 0.402282454450375 7.33158812399436e-06 miRNATAP -0.103217938168158 0.00730851130742136 NA NA NA hsa-miR-181a-5p C8A 0.250113435902954 0.0551933249319293 -2.64296437848277 1.37331913094116e-15 miRNAWalker2_validate -1.02845402979444 1.22956976846366e-16 NA NA NA hsa-miR-19b-3p C8orf4 0.601279551368824 0.00016685097085251 -2.72963175230849 2.76469480945754e-34 miRNATAP -0.203755606145647 0.00584192500900762 NA NA NA hsa-miR-432-5p C8orf46 -0.536178819038888 0.0748623258271085 -0.194156020160941 0.471387075043507 miRNATAP -0.208815207358166 1.40753889786084e-06 NA NA NA hsa-miR-182-5p C9orf72 1.96601340710222 4.39326175603633e-09 -1.08779192214551 6.70793848212492e-13 miRNATAP -0.107945718986517 8.96310279675189e-07 NA NA NA hsa-miR-192-5p CA12 -0.50188499512787 0.00344713341196035 2.34009290257016 5.88059078525048e-07 mirMAP -0.283610005786242 0.0355075315972785 NA NA NA hsa-miR-181a-5p CA13 0.250113435902954 0.0551933249319293 -1.25765459479166 8.96894103763698e-10 mirMAP -0.25854770468 0.000984932215371269 NA NA NA hsa-miR-181b-5p CA13 0.488256489401108 0.00105321129419701 -1.25765459479166 8.96894103763698e-10 mirMAP -0.287227471449388 2.38466126975356e-05 NA NA NA hsa-miR-19b-3p CA13 0.601279551368824 0.00016685097085251 -1.25765459479166 8.96894103763698e-10 miRNAWalker2_validate -0.133744572788983 0.0359430007661968 NA NA NA hsa-miR-20a-5p CA5B 0.854326758727003 5.04256669663285e-07 0.772932318052634 9.14252785241903e-06 mirMAP -0.158603429966099 0.00143335848151017 NA NA NA hsa-miR-192-5p CA8 -0.50188499512787 0.00344713341196035 1.30458530653828 6.77357214311562e-06 miRNAWalker2_validate -0.350278797623789 2.19532146421647e-05 NA NA NA hsa-miR-15a-5p CAB39 0.349521211668244 0.000770735998804736 -0.152804524606349 0.00962811714746276 miRNATAP -0.108425253583809 7.85731490720904e-05 NA NA NA hsa-miR-192-3p CAB39L -0.6401165114007 0.000266272092403814 -0.504869726858055 1.1927547950473e-05 mirMAP -0.122781017802891 0.0001220181908619 NA NA NA hsa-miR-192-5p CAB39L -0.50188499512787 0.00344713341196035 -0.504869726858055 1.1927547950473e-05 miRNAWalker2_validate -0.168189458314805 2.40399921852626e-07 NA NA NA hsa-miR-181b-5p CABLES1 0.488256489401108 0.00105321129419701 -0.23961548519258 0.15759844149133 mirMAP -0.132641625745201 0.0165615180037337 NA NA NA hsa-miR-30e-5p CACHD1 -0.627815042856657 3.02205690184908e-10 -0.358215394477564 0.101222328651448 MirTarget -0.208914968563804 0.0484275901349842 NA NA NA hsa-miR-34a-5p CACHD1 1.03694231790865 5.74864019540594e-14 -0.358215394477564 0.101222328651448 MirTarget -0.325580093733265 1.25657787199307e-05 NA NA NA hsa-miR-192-5p CACNA1C -0.50188499512787 0.00344713341196035 0.946440250430891 1.06436399202531e-05 mirMAP -0.485416252348342 3.06182549190867e-16 NA NA NA hsa-miR-30e-5p CACNA1C -0.627815042856657 3.02205690184908e-10 0.946440250430891 1.06436399202531e-05 mirMAP -0.383622413991233 0.000242519659254916 NA NA NA hsa-miR-148a-3p CACNA1E -0.748702855596996 3.93313343865641e-07 1.61336046300478 3.88892981462269e-05 mirMAP -0.551916698525026 1.72909128498258e-05 NA NA NA hsa-miR-505-5p CACNA1E -0.768282569967001 1.14662846595407e-05 1.61336046300478 3.88892981462269e-05 mirMAP -0.252249364560451 0.0210581970693645 NA NA NA hsa-miR-192-3p CACNA1I -0.6401165114007 0.000266272092403814 0.68856788879411 0.0811087983044381 mirMAP -0.241258141512071 0.0272798942620579 NA NA NA hsa-miR-34a-5p CACNA2D2 1.03694231790865 5.74864019540594e-14 -0.352692703137883 0.11173297477812 mirMAP -0.228063531597874 0.00272261615796924 NA NA NA hsa-miR-27b-3p CACNA2D3 -0.823491817819754 9.20935302746823e-14 0.363185883059655 0.207081897289803 miRNATAP -0.246050693953525 0.047645269677538 NA NA NA hsa-miR-30e-5p CACNB4 -0.627815042856657 3.02205690184908e-10 1.93077881386314 4.3815389499992e-11 mirMAP -0.415609879371581 0.00416054738535645 NA NA NA hsa-miR-29c-3p CACNG4 -1.4367517608807 1.61767774905781e-21 1.21398947224201 0.0158504303421043 miRNATAP -0.692310517334316 7.0137294815078e-06 NA NA NA hsa-miR-455-3p CAD -1.3998033821095 5.72010709806871e-17 1.30366063437095 3.77358876206119e-30 miRNAWalker2_validate -0.152316122378051 8.52339940065751e-06 NA NA NA hsa-miR-505-5p CAD -0.768282569967001 1.14662846595407e-05 1.30366063437095 3.77358876206119e-30 miRNAWalker2_validate -0.157731138307386 2.68983956559796e-06 NA NA NA hsa-miR-182-5p CADM1 1.96601340710222 4.39326175603633e-09 -0.0259171422650883 0.886286112596045 miRNATAP -0.113024578325019 1.00354596466421e-05 24445397 TGF β upregulates miR 182 expression to promote gallbladder cancer metastasis by targeting CADM1; We further identified that the cell adhesion molecule1 CADM1 is a new target gene of miR-182 miR-182 negatively regulates CADM1 expression in vitro and in vivo metastasis bladder cancer hsa-miR-21-5p CADM2 1.51084295924322 1.54551622173259e-34 -2.31674580160095 5.89007396472084e-10 mirMAP;miRNATAP -0.379737941440532 0.00647561026230968 NA NA NA hsa-miR-192-3p CADM3 -0.6401165114007 0.000266272092403814 -2.00301532743766 4.77110031398797e-08 mirMAP -0.556221831068184 4.47138930208908e-08 NA NA NA hsa-miR-455-3p CADM3 -1.3998033821095 5.72010709806871e-17 -2.00301532743766 4.77110031398797e-08 mirMAP -0.279233568422275 0.00764482002104434 NA NA NA hsa-miR-19b-3p CADM4 0.601279551368824 0.00016685097085251 -0.335843636232197 0.159341411564077 miRNATAP -0.200676336146742 0.00561121269165888 NA NA NA hsa-miR-455-5p CADPS2 -0.270546034117157 0.0581320703577731 0.0218088212398091 0.885514943251668 MirTarget;miRanda -0.26305929693325 2.70512694998938e-07 NA NA NA hsa-miR-146b-5p CALCRL 0.419719546795449 0.0457375823220155 0.113312063970645 0.548528453624408 miRanda -0.110683612588913 0.0113771167927904 NA NA NA hsa-miR-15a-5p CALD1 0.349521211668244 0.000770735998804736 -0.530621733887527 1.64156095327975e-08 miRNAWalker2_validate -0.174506640820017 9.41291417619924e-05 NA NA NA hsa-miR-20a-5p CALD1 0.854326758727003 5.04256669663285e-07 -0.530621733887527 1.64156095327975e-08 miRNATAP -0.195440267483236 9.46993586193112e-14 NA NA NA hsa-miR-20b-5p CALD1 0.457668023910379 0.0285865211936156 -0.530621733887527 1.64156095327975e-08 miRNATAP -0.102403624151832 3.25316355225017e-06 NA NA NA hsa-miR-21-5p CALD1 1.51084295924322 1.54551622173259e-34 -0.530621733887527 1.64156095327975e-08 miRNAWalker2_validate;MirTarget -0.273877053450713 3.45477925002901e-16 NA NA NA hsa-miR-27b-3p CALM3 -0.823491817819754 9.20935302746823e-14 0.208010932671678 0.0152703300792942 miRNAWalker2_validate;miRNATAP -0.106848099385636 0.00371755816496827 NA NA NA hsa-miR-29c-3p CALU -1.4367517608807 1.61767774905781e-21 0.322728190111391 0.000943151327461812 MirTarget -0.130411391006099 1.27281332352624e-05 NA NA NA hsa-miR-30b-5p CALU -0.54056186708617 2.44688760798341e-05 0.322728190111391 0.000943151327461812 MirTarget -0.118469443552983 0.00136183728012661 NA NA NA hsa-miR-17-3p CAMK1D 0.410352776142368 0.00422200500748636 -0.401457997700563 0.123544927768406 mirMAP -0.587387079353269 1.18021498522848e-11 NA NA NA hsa-miR-192-3p CAMK1D -0.6401165114007 0.000266272092403814 -0.401457997700563 0.123544927768406 mirMAP -0.255374153034918 0.00037432686891519 NA NA NA hsa-miR-34a-5p CAMK2B 1.03694231790865 5.74864019540594e-14 -3.79443915567367 4.19182064533683e-17 mirMAP -0.516635641071732 0.00134707229894061 NA NA NA hsa-miR-132-3p CAMTA1 0.323796239695997 0.00272093067935091 -0.308821305875669 0.001102834823798 MirTarget -0.174418620385188 4.48351320664028e-05 NA NA NA hsa-miR-221-3p CAMTA1 1.12244756358612 3.48370308238012e-13 -0.308821305875669 0.001102834823798 MirTarget -0.128246997831631 9.23948054031477e-06 NA NA NA hsa-miR-222-3p CAMTA1 1.08574156066353 1.76407192348131e-11 -0.308821305875669 0.001102834823798 MirTarget -0.11256448836706 5.16004861579148e-05 NA NA NA hsa-miR-20a-5p CAMTA2 0.854326758727003 5.04256669663285e-07 -0.349513498841022 7.64783665378357e-05 MirTarget -0.108244239607943 1.44349782249415e-05 NA NA NA hsa-miR-34a-5p CAPN6 1.03694231790865 5.74864019540594e-14 -2.67464448971242 3.55600727752968e-08 miRNATAP -0.474090388866239 0.00515692879270897 NA NA NA hsa-miR-146b-5p CAPS 0.419719546795449 0.0457375823220155 0.581176214710707 0.000272844966219162 miRanda -0.107023874860517 0.00401669155240795 NA NA NA hsa-miR-146b-5p CAPS2 0.419719546795449 0.0457375823220155 -0.808956284557473 7.63799717406795e-05 miRanda -0.181028434973401 0.000141410588510757 NA NA NA hsa-miR-27b-3p CAPZA1 -0.823491817819754 9.20935302746823e-14 0.0745832397420099 0.287801594621395 miRNATAP -0.108511153217582 0.00028298026400426 NA NA NA hsa-miR-455-5p CARD14 -0.270546034117157 0.0581320703577731 0.0885483724913634 0.674533541927276 miRanda -0.317155624326365 9.33141488029476e-06 NA NA NA hsa-miR-455-5p CARD8 -0.270546034117157 0.0581320703577731 0.132075523103739 0.180382608176828 MirTarget;miRanda -0.112322956318979 0.000816914786370328 NA NA NA hsa-miR-20a-5p CASC4 0.854326758727003 5.04256669663285e-07 -0.459665382720857 2.26052627896481e-06 MirTarget -0.190542702668712 2.01557220224231e-12 NA NA NA hsa-miR-21-5p CASC4 1.51084295924322 1.54551622173259e-34 -0.459665382720857 2.26052627896481e-06 miRNATAP -0.140945392919455 7.51563165261554e-05 NA NA NA hsa-miR-15a-5p CASK 0.349521211668244 0.000770735998804736 0.42777049580758 0.000114042576949703 MirTarget;miRNATAP -0.107551525308806 0.0408408945638451 NA NA NA hsa-miR-181a-5p CASK 0.250113435902954 0.0551933249319293 0.42777049580758 0.000114042576949703 mirMAP -0.15804764209001 0.000147222060393676 NA NA NA hsa-miR-181b-5p CASK 0.488256489401108 0.00105321129419701 0.42777049580758 0.000114042576949703 mirMAP -0.109001854494032 0.00270234160607011 NA NA NA hsa-miR-19b-3p CASK 0.601279551368824 0.00016685097085251 0.42777049580758 0.000114042576949703 mirMAP -0.197380809097737 3.04396880260588e-09 NA NA NA hsa-miR-20a-5p CASK 0.854326758727003 5.04256669663285e-07 0.42777049580758 0.000114042576949703 mirMAP -0.195138172194598 2.93563218335273e-10 NA NA NA hsa-miR-29c-3p CASKIN1 -1.4367517608807 1.61767774905781e-21 1.73450894991447 2.58018983860941e-08 mirMAP -0.665606570225816 2.65969491475836e-12 NA NA NA hsa-miR-455-5p CASP1 -0.270546034117157 0.0581320703577731 -0.651363840672725 9.15333066765817e-05 miRanda -0.32561364833753 8.42175427274093e-09 NA NA NA hsa-miR-455-5p CASP4 -0.270546034117157 0.0581320703577731 -0.409544916089211 0.000646082337545093 miRanda -0.241379210140365 2.67865947881455e-09 NA NA NA hsa-miR-455-5p CASP8 -0.270546034117157 0.0581320703577731 0.329003138913902 0.000294949473828384 miRanda -0.154954229285754 5.1724046517642e-07 NA NA NA hsa-miR-146b-5p CASR 0.419719546795449 0.0457375823220155 -3.09354922799373 1.45515579446105e-14 miRanda -0.193560961444894 0.0451904160013163 26178670 miR 135b and miR 146b dependent silencing of calcium sensing receptor expression in colorectal tumors; Inhibition of miR-135b and miR-146b expression led to high CaSR levels and significantly reduced proliferation; In samples of colorectal tumors we observed overexpression of miR-135b and miR-146b and this correlated inversely with CaSR expression miR-135b: r = -0.684 p < 0.001 and miR-146b: r = -0.448 p < 0.001 supporting our in vitro findings; We demonstrate that miR-135b and miR-146b target the CaSR and reduce its expression in colorectal tumors reducing the antiproliferative and prodifferentiating actions of calcium colorectal cancer hsa-miR-221-3p CASR 1.12244756358612 3.48370308238012e-13 -3.09354922799373 1.45515579446105e-14 MirTarget -0.387673661676025 0.00241027141784746 NA NA NA hsa-miR-222-3p CASR 1.08574156066353 1.76407192348131e-11 -3.09354922799373 1.45515579446105e-14 MirTarget -0.439445390430851 0.000327372341098158 NA NA NA hsa-miR-19b-3p CAST 0.601279551368824 0.00016685097085251 -0.326447157492815 2.68364578201594e-05 miRNATAP -0.159307399387286 5.84919487369529e-12 NA NA NA hsa-miR-222-3p CAST 1.08574156066353 1.76407192348131e-11 -0.326447157492815 2.68364578201594e-05 miRNAWalker2_validate -0.158864197438327 1.44083859123376e-12 NA NA NA hsa-miR-455-5p CAST -0.270546034117157 0.0581320703577731 -0.326447157492815 2.68364578201594e-05 miRanda;miRNATAP -0.119589597853589 6.44387894113961e-06 NA NA NA hsa-miR-148a-3p CASZ1 -0.748702855596996 3.93313343865641e-07 0.0447027176865755 0.759254760507176 miRNATAP -0.216249768226474 4.51223951061093e-06 NA NA NA hsa-miR-455-5p CASZ1 -0.270546034117157 0.0581320703577731 0.0447027176865755 0.759254760507176 miRanda;miRNATAP -0.154455046165385 0.00190530668892122 NA NA NA hsa-miR-181b-5p CAT 0.488256489401108 0.00105321129419701 -1.65049060277008 8.91987155536677e-23 miRNAWalker2_validate -0.498596106276817 2.48505880380441e-19 NA NA NA hsa-miR-20a-5p CAV1 0.854326758727003 5.04256669663285e-07 0.178366589482821 0.179773451413996 miRNATAP -0.170609324845359 4.77162158971638e-06 NA NA NA hsa-miR-192-3p CAV2 -0.6401165114007 0.000266272092403814 -0.672599196640157 0.00154731555861785 MirTarget -0.122678293035386 0.0377634219578066 NA NA NA hsa-miR-20a-5p CAV2 0.854326758727003 5.04256669663285e-07 -0.672599196640157 0.00154731555861785 mirMAP -0.330641103023048 2.91883907245052e-08 NA NA NA hsa-miR-148a-3p CBFA2T2 -0.748702855596996 3.93313343865641e-07 1.20918131407154 1.46538376039906e-30 mirMAP -0.144699434906485 8.4503321462579e-05 NA NA NA hsa-miR-29c-3p CBFA2T2 -1.4367517608807 1.61767774905781e-21 1.20918131407154 1.46538376039906e-30 mirMAP -0.362703447898535 7.38336534368061e-29 NA NA NA hsa-miR-15a-5p CBFA2T3 0.349521211668244 0.000770735998804736 -2.46986232951484 6.58727752397177e-29 MirTarget;miRNATAP -0.319119826911296 0.00434804496720368 NA NA NA hsa-miR-182-5p CBFA2T3 1.96601340710222 4.39326175603633e-09 -2.46986232951484 6.58727752397177e-29 MirTarget;miRNATAP -0.12526801919991 0.000205025698927401 NA NA NA hsa-miR-34a-5p CBFA2T3 1.03694231790865 5.74864019540594e-14 -2.46986232951484 6.58727752397177e-29 MirTarget;miRNATAP -0.382167003319208 2.31404108851503e-06 NA NA NA hsa-miR-27b-3p CBFB -0.823491817819754 9.20935302746823e-14 -0.0303437811013678 0.730639909137883 MirTarget;miRNATAP -0.190189250108295 3.5255897516604e-07 NA NA NA hsa-miR-192-5p CBL -0.50188499512787 0.00344713341196035 0.0549640409712908 0.654706328872111 mirMAP -0.235199499067807 3.95863847644446e-12 NA NA NA hsa-miR-29c-3p CBL -1.4367517608807 1.61767774905781e-21 0.0549640409712908 0.654706328872111 mirMAP -0.10899286694415 0.00381986136405013 NA NA NA hsa-miR-182-5p CBLN4 1.96601340710222 4.39326175603633e-09 -1.66592302163761 0.000149471902398456 miRNATAP -0.417226501178035 1.3218424282784e-11 NA NA NA hsa-miR-20a-5p CBLN4 0.854326758727003 5.04256669663285e-07 -1.66592302163761 0.000149471902398456 miRNATAP -0.545376138945613 1.18811195586234e-05 NA NA NA hsa-miR-132-3p CBWD3 0.323796239695997 0.00272093067935091 -0.675462571944565 1.19900987247376e-06 MirTarget -0.216360792838556 0.000673687775020618 NA NA NA hsa-miR-221-3p CBWD3 1.12244756358612 3.48370308238012e-13 -0.675462571944565 1.19900987247376e-06 MirTarget -0.164847279062406 0.000129011336258364 NA NA NA hsa-miR-222-3p CBWD3 1.08574156066353 1.76407192348131e-11 -0.675462571944565 1.19900987247376e-06 MirTarget -0.119917911562146 0.00383431550673116 NA NA NA hsa-miR-29c-3p CBX1 -1.4367517608807 1.61767774905781e-21 0.785716543008194 2.64595285870767e-18 miRNATAP -0.297838462001487 2.30637920845867e-28 NA NA NA hsa-miR-192-3p CBX2 -0.6401165114007 0.000266272092403814 2.25351244295968 1.73782786388514e-22 mirMAP -0.361931200652024 5.20156394487343e-08 NA NA NA hsa-miR-29c-3p CBX2 -1.4367517608807 1.61767774905781e-21 2.25351244295968 1.73782786388514e-22 miRNATAP -0.489743689744466 2.54398320619688e-11 NA NA NA hsa-miR-30e-5p CBX3 -0.627815042856657 3.02205690184908e-10 0.524741548804984 1.00573650688867e-13 MirTarget -0.183358159743634 1.07754401453522e-07 NA NA NA hsa-miR-148a-3p CBX5 -0.748702855596996 3.93313343865641e-07 0.352720475583158 0.00158496538783418 mirMAP -0.154538700330372 2.1011094438904e-05 NA NA NA hsa-miR-15a-5p CBX5 0.349521211668244 0.000770735998804736 0.352720475583158 0.00158496538783418 miRNATAP -0.112173267748632 0.0336546782146838 NA NA NA hsa-miR-192-3p CBX5 -0.6401165114007 0.000266272092403814 0.352720475583158 0.00158496538783418 mirMAP;miRNATAP -0.192483666709737 2.15486145465618e-10 NA NA NA hsa-miR-194-5p CBX5 -0.292530160992458 0.0996141384876663 0.352720475583158 0.00158496538783418 mirMAP -0.201008248352996 2.30337976172269e-11 NA NA NA hsa-miR-29c-3p CBX5 -1.4367517608807 1.61767774905781e-21 0.352720475583158 0.00158496538783418 miRNATAP -0.134070207088372 9.17675930101363e-05 NA NA NA hsa-miR-224-3p CBX6 1.40770116795301 1.31426607144612e-08 -0.135925898836227 0.562356772831778 mirMAP -0.163448648103912 0.000351212501632372 NA NA NA hsa-miR-29c-3p CBX6 -1.4367517608807 1.61767774905781e-21 -0.135925898836227 0.562356772831778 miRNATAP -0.185428111502926 0.0101621093593821 NA NA NA hsa-miR-181a-5p CBX7 0.250113435902954 0.0551933249319293 -0.0772822295902893 0.529369946505877 MirTarget;miRNATAP -0.274609406820937 1.20274953682673e-09 NA NA NA hsa-miR-181b-5p CBX7 0.488256489401108 0.00105321129419701 -0.0772822295902893 0.529369946505877 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.297526454109628 1.70841481752323e-14 NA NA NA hsa-miR-19b-3p CBX7 0.601279551368824 0.00016685097085251 -0.0772822295902893 0.529369946505877 mirMAP;miRNATAP -0.159618945045325 1.56807168851445e-05 NA NA NA hsa-miR-20a-5p CBX7 0.854326758727003 5.04256669663285e-07 -0.0772822295902893 0.529369946505877 mirMAP -0.169835367216151 7.64538648057388e-07 NA NA NA hsa-miR-29c-3p CBX8 -1.4367517608807 1.61767774905781e-21 1.25574859944463 2.18207641391983e-24 mirMAP -0.168904933607175 2.33004980837501e-05 NA NA NA hsa-miR-20a-5p CC2D1A 0.854326758727003 5.04256669663285e-07 0.260393841917763 0.00868880391181539 MirTarget;miRNATAP -0.119133698059461 1.97701215858317e-05 NA NA NA hsa-miR-192-3p CC2D2A -0.6401165114007 0.000266272092403814 0.0413438828029351 0.796767950710413 MirTarget -0.385316058030822 8.64702508767588e-20 NA NA NA hsa-miR-455-5p CC2D2A -0.270546034117157 0.0581320703577731 0.0413438828029351 0.796767950710413 miRanda -0.194028612349973 0.00038686114473203 NA NA NA hsa-miR-20a-5p CCBE1 0.854326758727003 5.04256669663285e-07 -5.45607436300535 1.74314530465254e-46 mirMAP -0.637723276198193 1.01620399244815e-07 NA NA NA hsa-miR-20a-5p CCDC103 0.854326758727003 5.04256669663285e-07 -0.0347332024261309 0.842632159365499 mirMAP -0.139448497133698 0.00479910785515642 NA NA NA hsa-miR-455-5p CCDC113 -0.270546034117157 0.0581320703577731 -0.246871340455217 0.303122188278183 miRanda;miRNATAP -0.517245817695006 1.22902727085555e-10 NA NA NA hsa-miR-29c-3p CCDC117 -1.4367517608807 1.61767774905781e-21 0.129046545647341 0.171605248088927 MirTarget;miRNATAP -0.10791250373646 0.000181071361899961 NA NA NA hsa-miR-21-5p CCDC121 1.51084295924322 1.54551622173259e-34 0.0857156966036231 0.430175996609146 MirTarget -0.211628505009972 5.68139329018811e-08 NA NA NA hsa-miR-222-3p CCDC126 1.08574156066353 1.76407192348131e-11 -0.21846019608397 0.0208559822914175 MirTarget -0.11485897902805 3.31893943408702e-05 NA NA NA hsa-miR-192-3p CCDC14 -0.6401165114007 0.000266272092403814 0.862276663854896 7.84466382269606e-13 MirTarget -0.117595823423101 0.000556999098394804 NA NA NA hsa-miR-15a-5p CCDC149 0.349521211668244 0.000770735998804736 -0.207125955392873 0.240182045752635 MirTarget -0.165812806244819 0.0461173748628528 NA NA NA hsa-miR-21-5p CCDC152 1.51084295924322 1.54551622173259e-34 -1.09230945352764 5.84433015164347e-09 mirMAP -0.609464701764088 6.12032620010967e-20 NA NA NA hsa-miR-127-3p CCDC40 -1.0751374948053 2.19322892330221e-05 1.02634614610991 2.39339583345177e-09 miRanda -0.173865609571042 1.35151149669908e-07 NA NA NA hsa-miR-409-3p CCDC40 -0.499649792570937 0.0526751181520117 1.02634614610991 2.39339583345177e-09 mirMAP -0.15836355397822 1.33437931693287e-06 NA NA NA hsa-miR-222-3p CCDC47 1.08574156066353 1.76407192348131e-11 0.0113470548316013 0.891678036762375 miRNAWalker2_validate -0.134518299721352 2.32039893934131e-08 NA NA NA hsa-miR-148a-3p CCDC6 -0.748702855596996 3.93313343865641e-07 0.0486288224569229 0.487131811557696 MirTarget -0.162224288737069 1.91367643340457e-13 NA NA NA hsa-miR-99a-5p CCDC6 -1.51481656384839 3.93230057259529e-14 0.0486288224569229 0.487131811557696 miRNAWalker2_validate -0.107375418665633 1.92330135613592e-11 NA NA NA hsa-miR-146b-5p CCDC85A 0.419719546795449 0.0457375823220155 0.737521480033408 9.22662034200037e-05 miRanda -0.132648907872973 0.00256985780829615 NA NA NA hsa-miR-148a-3p CCDC85A -0.748702855596996 3.93313343865641e-07 0.737521480033408 9.22662034200037e-05 miRNATAP -0.162313393513611 0.00894922650017325 NA NA NA hsa-miR-29c-3p CCDC85C -1.4367517608807 1.61767774905781e-21 0.715583791803459 8.12293475957308e-09 mirMAP -0.142940633384065 0.000219968741178564 NA NA NA hsa-miR-30e-5p CCDC97 -0.627815042856657 3.02205690184908e-10 0.764662989960692 1.22566229712115e-22 MirTarget -0.173128472097225 1.10672543953786e-05 NA NA NA hsa-miR-192-3p CCL18 -0.6401165114007 0.000266272092403814 0.307693769123854 0.328503771445359 MirTarget -0.20490785150647 0.0185435750613218 NA NA NA hsa-miR-34a-5p CCL22 1.03694231790865 5.74864019540594e-14 -1.06386932539822 0.000196807178151015 miRNAWalker2_validate;miRTarBase;MirTarget -0.373112833790649 0.000150013567554074 22975373 TGF β miR 34a CCL22 signaling induced Treg cell recruitment promotes venous metastases of HBV positive hepatocellular carcinoma; Mechanistically elevated TGF-β activity associated with the persistent presence of HBV in the liver tissue suppresses the expression of microRNA-34a leading to enhanced production of chemokine CCL22 which recruits regulatory T Treg cells to facilitate immune escape metastasis liver cancer hsa-miR-455-5p CCL26 -0.270546034117157 0.0581320703577731 1.62407692519363 1.16498331115593e-06 miRanda -0.269564320848 0.0201387244598147 NA NA NA hsa-miR-192-5p CCL3L1 -0.50188499512787 0.00344713341196035 -0.813822110806966 0.00487501953312684 miRNAWalker2_validate -0.283347648837424 0.000550015023804458 NA NA NA hsa-miR-27b-3p CCNA2 -0.823491817819754 9.20935302746823e-14 3.36794922367745 6.53886370047174e-43 miRNATAP -0.54120082992627 3.46716161944693e-06 NA NA NA hsa-miR-29c-3p CCNA2 -1.4367517608807 1.61767774905781e-21 3.36794922367745 6.53886370047174e-43 MirTarget -0.922743011617596 1.63915073620724e-32 NA NA NA hsa-miR-19b-3p CCND1 0.601279551368824 0.00016685097085251 -0.901747452525989 1.22363850855738e-05 miRNATAP -0.340975400639976 4.6454998539434e-08 NA NA NA hsa-miR-20a-5p CCND1 0.854326758727003 5.04256669663285e-07 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.332506713675419 1.04479750525145e-08 NA NA NA hsa-miR-20b-5p CCND1 0.457668023910379 0.0285865211936156 -0.901747452525989 1.22363850855738e-05 MirTarget;miRNATAP -0.230429652941375 1.603682834845e-06 NA NA NA hsa-miR-503-5p CCND1 0.191949282338049 0.268420664548092 -0.901747452525989 1.22363850855738e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.155187994375291 0.00815133470022587 26047605;23731275 MiR 503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression; Overexpression of miR-503 in breast cancer cell lines reduced cell proliferation through inducing G0/G1 cell cycle arrest by targeting CCND1;MicroRNA 503 suppresses proliferation and cell cycle progression of endometrioid endometrial cancer by negatively regulating cyclin D1; CCND1 has a binding sequence of miR-503 within its 3' untranslated region and was confirmed to be a direct target of miR-503 by the fluorescent reporter assays; Increasing the miR-503 level in EEC cells suppressed cell viability colon formation activity and cell-cycle progression and the inhibited oncogenic phenotypes induced by miR-503 were alleviated by ectopic expression of CCND1 without the untranslated region sequence; Collectively this study suggested that miR-503 plays a tumor-suppressor role by targeting CCND1; Abnormal suppression of miR-503 leads to an increase in the CCND1 level which may promote carcinogenesis and progression of EEC ;progression;tumorigenesis breast cancer;endometrial cancer hsa-miR-19b-3p CCND2 0.601279551368824 0.00016685097085251 0.356451160382274 0.0365641518216489 miRNAWalker2_validate;MirTarget;miRNATAP -0.119904158273959 0.0208215571869961 NA NA NA hsa-miR-20a-5p CCND2 0.854326758727003 5.04256669663285e-07 0.356451160382274 0.0365641518216489 miRNAWalker2_validate;miRTarBase;miRNATAP -0.156120931730772 0.0012098497067071 NA NA NA hsa-miR-27b-3p CCND3 -0.823491817819754 9.20935302746823e-14 0.0767102129984094 0.478427267753328 miRNAWalker2_validate -0.236832359235505 2.50262257150465e-07 NA NA NA hsa-miR-192-5p CCNE1 -0.50188499512787 0.00344713341196035 3.04640353472202 4.5986250804531e-28 miRNAWalker2_validate -0.353990461529605 2.35568212305901e-05 NA NA NA hsa-miR-215-5p CCNE1 -0.981544773246509 3.14452272477156e-05 3.04640353472202 4.5986250804531e-28 miRNAWalker2_validate -0.127382376766865 0.0366833296900111 NA NA NA hsa-miR-30c-5p CCNE2 -0.432111642767632 0.000159764714931007 2.01834184083791 5.42527234853282e-21 miRNATAP -0.190760531928298 0.0478037459406433 NA NA NA hsa-miR-132-3p CCNG1 0.323796239695997 0.00272093067935091 -0.0461189096804278 0.640330790441284 MirTarget -0.192885004183872 1.30455410377392e-05 NA NA NA hsa-miR-181a-5p CCNG1 0.250113435902954 0.0551933249319293 -0.0461189096804278 0.640330790441284 miRNAWalker2_validate -0.218994113425088 1.51341663088512e-09 NA NA NA hsa-miR-21-5p CCNG1 1.51084295924322 1.54551622173259e-34 -0.0461189096804278 0.640330790441284 miRNAWalker2_validate -0.131168170626415 0.000240629548489461 NA NA NA hsa-miR-192-3p CCNG2 -0.6401165114007 0.000266272092403814 0.198342536240394 0.0998646636491728 MirTarget -0.172909903443718 1.39509815706713e-07 NA NA NA hsa-miR-455-5p CCNI -0.270546034117157 0.0581320703577731 -1.00125469351946 4.23051901492723e-09 miRanda -0.145821987814868 0.0142310763314391 NA NA NA hsa-miR-29c-3p CCNI2 -1.4367517608807 1.61767774905781e-21 0.987990813889281 0.000261133291504858 MirTarget -0.339477473336234 4.66284510537003e-05 NA NA NA hsa-miR-146b-5p CCNJ 0.419719546795449 0.0457375823220155 -0.398192855653257 0.0818003883465896 PITA;miRanda;miRNATAP -0.125814591088204 0.0178360383675623 NA NA NA hsa-miR-15a-5p CCNJ 0.349521211668244 0.000770735998804736 -0.398192855653257 0.0818003883465896 miRNATAP -0.231725588585401 0.0318918418759286 NA NA NA hsa-miR-194-5p CCNJ -0.292530160992458 0.0996141384876663 -0.398192855653257 0.0818003883465896 MirTarget -0.235972277398735 0.000164066194799236 NA NA NA hsa-miR-455-3p CCNJ -1.3998033821095 5.72010709806871e-17 -0.398192855653257 0.0818003883465896 MirTarget;miRNATAP -0.130272154707473 0.042910901241805 NA NA NA hsa-miR-34a-5p CCNL1 1.03694231790865 5.74864019540594e-14 -0.433646578034029 6.59862017093543e-07 miRNAWalker2_validate -0.106449501419046 0.000411175275262379 NA NA NA hsa-miR-192-5p CCNO -0.50188499512787 0.00344713341196035 1.78909423167233 1.94025068480648e-05 miRNAWalker2_validate -0.510543705454595 1.817952514309e-05 NA NA NA hsa-miR-15a-5p CCNT1 0.349521211668244 0.000770735998804736 -0.888867136119737 0.00127505554590264 miRNATAP -0.319499589662663 0.0145207409450001 NA NA NA hsa-miR-132-3p CCNT2 0.323796239695997 0.00272093067935091 -0.125072957809514 0.25328235743992 miRNATAP -0.105371175048441 0.0335335421292547 NA NA NA hsa-miR-29c-3p CCNYL1 -1.4367517608807 1.61767774905781e-21 -0.103926823626262 0.234054684883571 MirTarget -0.153343452155816 5.72119890116977e-09 NA NA NA hsa-miR-19b-3p CCPG1 0.601279551368824 0.00016685097085251 -0.691239780213844 2.04230396227421e-10 MirTarget -0.185160997774916 2.4957084559951e-08 NA NA NA hsa-miR-455-5p CCPG1 -0.270546034117157 0.0581320703577731 -0.691239780213844 2.04230396227421e-10 miRanda -0.161124470001677 1.95444259447429e-05 NA NA NA hsa-miR-455-5p CCR5 -0.270546034117157 0.0581320703577731 -0.543856922971999 0.0152521610052174 miRanda -0.241646122064264 0.00164793703628127 NA NA NA hsa-miR-148a-3p CCT6A -0.748702855596996 3.93313343865641e-07 0.807199846325453 3.99983471227829e-24 MirTarget -0.142589901920738 1.49586171325104e-07 NA NA NA hsa-miR-30e-5p CCT6A -0.627815042856657 3.02205690184908e-10 0.807199846325453 3.99983471227829e-24 miRNAWalker2_validate -0.309396141231563 3.77302765515096e-15 NA NA NA hsa-miR-15a-5p CCT6B 0.349521211668244 0.000770735998804736 -1.70232187588657 1.38695508577499e-11 miRNAWalker2_validate -0.365452372959822 0.0026532838798942 NA NA NA hsa-miR-455-5p CD226 -0.270546034117157 0.0581320703577731 -2.15141566557593 1.24720391579337e-17 miRanda -0.178864087055484 0.0469250224419622 NA NA NA hsa-miR-20a-5p CD274 0.854326758727003 5.04256669663285e-07 -1.27197015327625 1.91338057077084e-08 MirTarget;miRNATAP -0.419422834501942 5.11594503516805e-11 NA NA NA hsa-miR-224-3p CD274 1.40770116795301 1.31426607144612e-08 -1.27197015327625 1.91338057077084e-08 MirTarget -0.134382337881586 0.00285144800801034 NA NA NA hsa-miR-455-5p CD274 -0.270546034117157 0.0581320703577731 -1.27197015327625 1.91338057077084e-08 miRanda -0.373712699409087 1.71811340616817e-06 NA NA NA hsa-miR-29c-3p CD276 -1.4367517608807 1.61767774905781e-21 -0.250922258401801 0.00880868889174289 MirTarget;miRNATAP -0.168783898062081 5.85120298630789e-09 24577056 Identifying microRNAs regulating B7 H3 in breast cancer: the clinical impact of microRNA 29c breast cancer hsa-miR-27b-3p CD28 -0.823491817819754 9.20935302746823e-14 0.296648468301709 0.11433598708989 miRNATAP -0.207263340327522 0.010451315584138 NA NA NA hsa-miR-455-3p CD3E -1.3998033821095 5.72010709806871e-17 -0.683417323754103 0.00530115605535861 miRNATAP -0.235574122089077 0.000619278539286069 NA NA NA hsa-miR-455-5p CD3G -0.270546034117157 0.0581320703577731 -0.598282330915523 0.0375710166007396 miRanda -0.358696614137159 0.00026273481588115 NA NA NA hsa-miR-221-3p CD4 1.12244756358612 3.48370308238012e-13 -2.19805487067597 2.60882227268234e-32 MirTarget;miRNATAP -0.346525489965451 1.27856306501111e-08 NA NA NA hsa-miR-222-3p CD4 1.08574156066353 1.76407192348131e-11 -2.19805487067597 2.60882227268234e-32 MirTarget;miRNATAP -0.272198321306655 3.71087346944381e-06 NA NA NA hsa-miR-455-5p CD40 -0.270546034117157 0.0581320703577731 -0.616611813433681 0.00118040627612664 miRanda -0.218186453430219 0.000823000702341848 NA NA NA hsa-miR-27b-3p CD44 -0.823491817819754 9.20935302746823e-14 -0.0861213298199726 0.717927779502077 miRNATAP -0.346982595786675 0.000695530690953447 NA NA NA hsa-miR-181a-5p CD46 0.250113435902954 0.0551933249319293 0.355683608102144 0.000590741887482439 miRNAWalker2_validate;mirMAP -0.105907925470407 0.00655467965227416 NA NA NA hsa-miR-652-3p CD46 0.135945800164278 0.391695970197646 0.355683608102144 0.000590741887482439 miRNAWalker2_validate -0.120932545047172 0.000146898678131637 NA NA NA hsa-miR-15a-5p CD47 0.349521211668244 0.000770735998804736 -0.116991958454649 0.315813375960739 MirTarget -0.136293996877326 0.0129074855492666 NA NA NA hsa-miR-19b-3p CD47 0.601279551368824 0.00016685097085251 -0.116991958454649 0.315813375960739 MirTarget -0.202884852481428 5.34864168421854e-09 NA NA NA hsa-miR-455-5p CD47 -0.270546034117157 0.0581320703577731 -0.116991958454649 0.315813375960739 miRanda -0.195846506672299 6.69192315868028e-07 NA NA NA hsa-miR-224-3p CD53 1.40770116795301 1.31426607144612e-08 -0.795471947647577 3.11406924708723e-05 MirTarget -0.103389293632682 0.00611308253246105 NA NA NA hsa-miR-455-5p CD53 -0.270546034117157 0.0581320703577731 -0.795471947647577 3.11406924708723e-05 miRanda -0.305044370599891 3.08338902172328e-06 NA NA NA hsa-miR-19b-3p CD69 0.601279551368824 0.00016685097085251 -1.74691450716 3.50683306201239e-12 miRNATAP -0.154698293391138 0.0489230610687212 NA NA NA hsa-miR-20a-5p CD69 0.854326758727003 5.04256669663285e-07 -1.74691450716 3.50683306201239e-12 miRNATAP -0.219544994735417 0.00264853195477804 NA NA NA hsa-miR-455-3p CD80 -1.3998033821095 5.72010709806871e-17 -0.854953285713832 0.000389215029454455 MirTarget;PITA -0.274603838160275 4.94946663271419e-05 NA NA NA hsa-miR-192-5p CD83 -0.50188499512787 0.00344713341196035 -0.752923537233197 3.68171723467509e-07 miRNAWalker2_validate -0.15847156507221 0.000182702809873103 NA NA NA hsa-miR-19b-3p CD84 0.601279551368824 0.00016685097085251 -1.07374907964932 7.85138047657634e-06 MirTarget -0.215538832105879 0.00344554628852017 NA NA NA hsa-miR-192-5p CD93 -0.50188499512787 0.00344713341196035 0.152893293585773 0.246481042677798 MirTarget -0.232543254915553 2.08107954892632e-10 NA NA NA hsa-miR-455-3p CD93 -1.3998033821095 5.72010709806871e-17 0.152893293585773 0.246481042677798 miRNATAP -0.180542573121512 7.90934769133787e-07 NA NA NA hsa-miR-15a-5p CDC14B 0.349521211668244 0.000770735998804736 -1.18862488716786 6.19212759828214e-11 miRNAWalker2_validate;MirTarget -0.264133561370897 0.00255856972749859 NA NA NA hsa-miR-17-3p CDC14B 0.410352776142368 0.00422200500748636 -1.18862488716786 6.19212759828214e-11 MirTarget -0.411816770017806 2.8300203911774e-11 NA NA NA hsa-miR-192-5p CDC20 -0.50188499512787 0.00344713341196035 4.43876134810924 2.33731245396441e-49 miRNAWalker2_validate -0.257887721839452 0.00747315576024174 NA NA NA hsa-miR-215-5p CDC20 -0.981544773246509 3.14452272477156e-05 4.43876134810924 2.33731245396441e-49 miRNAWalker2_validate -0.210290018213749 0.00250187708869541 NA NA NA hsa-miR-29c-3p CDC23 -1.4367517608807 1.61767774905781e-21 0.463635495366116 5.65757358389337e-10 miRNAWalker2_validate -0.137258097204054 2.34594396923131e-09 NA NA NA hsa-miR-34a-5p CDC25A 1.03694231790865 5.74864019540594e-14 1.92057841155944 2.96621670231863e-18 miRNAWalker2_validate;miRNATAP -0.189467294029441 0.0166404872038177 NA NA NA hsa-miR-148a-3p CDC25B -0.748702855596996 3.93313343865641e-07 0.802575978153976 1.68584041760539e-08 miRNAWalker2_validate;miRNATAP -0.29297329943429 2.56785527501486e-10 25341915 Gene CDC25B might be the target gene of miR-148a according to the results of targetscan; CDC25B may be the target gene of miR-148a that plays a role in tumor suppressor gastric cancer hsa-miR-27b-3p CDC25B -0.823491817819754 9.20935302746823e-14 0.802575978153976 1.68584041760539e-08 miRNATAP -0.298569829692256 1.30532384058526e-06 NA NA NA hsa-miR-15a-5p CDC37L1 0.349521211668244 0.000770735998804736 -1.68074286794396 1.35044263041101e-36 MirTarget;miRNATAP -0.226522807323438 0.000926828285381459 NA NA NA hsa-miR-20a-5p CDC37L1 0.854326758727003 5.04256669663285e-07 -1.68074286794396 1.35044263041101e-36 MirTarget;miRNATAP -0.321174697738291 7.5246516441106e-16 NA NA NA hsa-miR-20b-5p CDC37L1 0.457668023910379 0.0285865211936156 -1.68074286794396 1.35044263041101e-36 MirTarget;miRNATAP -0.12165297860307 0.000314885051549026 NA NA NA hsa-miR-181a-5p CDC42BPA 0.250113435902954 0.0551933249319293 0.0504128376522637 0.704432077177647 MirTarget;miRNATAP -0.250733587935735 3.42852214318448e-07 NA NA NA hsa-miR-181b-5p CDC42BPA 0.488256489401108 0.00105321129419701 0.0504128376522637 0.704432077177647 MirTarget;miRNATAP -0.218747219015265 3.15924555392319e-07 NA NA NA hsa-miR-19b-3p CDC42BPA 0.601279551368824 0.00016685097085251 0.0504128376522637 0.704432077177647 MirTarget;miRNATAP -0.187090361706875 2.74924423944062e-06 NA NA NA hsa-miR-455-3p CDC42EP3 -1.3998033821095 5.72010709806871e-17 -0.402417005297056 0.00744881473009377 MirTarget -0.103901980800098 0.0140492591991813 NA NA NA hsa-miR-455-5p CDC42SE2 -0.270546034117157 0.0581320703577731 0.0960716529346435 0.220254646090276 miRanda -0.145358798058353 3.28284709045813e-08 NA NA NA hsa-miR-455-3p CDC45 -1.3998033821095 5.72010709806871e-17 4.18336861300281 2.12601818248365e-50 miRNAWalker2_validate -0.431328852958487 1.03919719048379e-06 NA NA NA hsa-miR-181b-5p CDC5L 0.488256489401108 0.00105321129419701 0.176206413769978 0.029009075721495 mirMAP -0.107017818513578 4.12480864395034e-05 NA NA NA hsa-miR-192-5p CDC7 -0.50188499512787 0.00344713341196035 2.01751950910415 4.47781393592943e-28 miRNAWalker2_validate -0.19830872980512 0.000359320910618898 NA NA NA hsa-miR-215-5p CDC7 -0.981544773246509 3.14452272477156e-05 2.01751950910415 4.47781393592943e-28 miRNAWalker2_validate -0.107716575020922 0.00749268034794886 NA NA NA hsa-miR-455-5p CDC7 -0.270546034117157 0.0581320703577731 2.01751950910415 4.47781393592943e-28 miRanda -0.141288330591948 0.0362291855247305 NA NA NA hsa-miR-455-5p CDC73 -0.270546034117157 0.0581320703577731 0.13214269415202 0.101689992373089 miRanda -0.109550073877788 6.24313812795378e-05 NA NA NA hsa-miR-192-5p CDCA4 -0.50188499512787 0.00344713341196035 1.27278228859461 1.15861071696374e-22 miRNAWalker2_validate -0.170399204355543 9.94973963518653e-06 NA NA NA hsa-miR-215-5p CDCA4 -0.981544773246509 3.14452272477156e-05 1.27278228859461 1.15861071696374e-22 miRNAWalker2_validate -0.136866796857177 8.37155707104647e-07 NA NA NA hsa-miR-29c-3p CDCA4 -1.4367517608807 1.61767774905781e-21 1.27278228859461 1.15861071696374e-22 MirTarget -0.467142257852647 3.90721594536045e-33 NA NA NA hsa-miR-30e-5p CDCA7 -0.627815042856657 3.02205690184908e-10 2.57202359254754 6.79638114277778e-12 MirTarget -0.73435881268712 7.29967393094028e-05 NA NA NA hsa-miR-146b-5p CDH1 0.419719546795449 0.0457375823220155 -0.925620688902025 3.54334396234e-05 miRanda -0.209827116364557 5.56204266800899e-05 NA NA NA hsa-miR-214-5p CDH13 -1.91497809567701 3.92955595018147e-12 2.78568708356452 4.86055423461083e-60 miRNATAP -0.122575315315724 0.000361100151040225 NA NA NA hsa-miR-30c-5p CDH13 -0.432111642767632 0.000159764714931007 2.78568708356452 4.86055423461083e-60 miRNATAP -0.312746112589712 0.000196030755521387 NA NA NA hsa-miR-27b-3p CDH24 -0.823491817819754 9.20935302746823e-14 2.17913448396389 2.09594267152664e-31 miRNATAP -0.38655213215607 7.56658561897812e-06 NA NA NA hsa-miR-505-5p CDH24 -0.768282569967001 1.14662846595407e-05 2.17913448396389 2.09594267152664e-31 miRNATAP -0.252190057596742 5.07387277764847e-06 NA NA NA hsa-miR-30b-5p CDK12 -0.54056186708617 2.44688760798341e-05 0.0633910075392592 0.431643772446267 MirTarget -0.125011544427262 3.45236094568576e-05 NA NA NA hsa-miR-132-3p CDK14 0.323796239695997 0.00272093067935091 -0.0249968813971337 0.858766472747201 MirTarget;miRNATAP -0.196865558258738 0.00191477519611863 NA NA NA hsa-miR-432-5p CDK14 -0.536178819038888 0.0748623258271085 -0.0249968813971337 0.858766472747201 miRNATAP -0.108573994459799 1.42584078855675e-06 NA NA NA hsa-miR-29c-3p CDK16 -1.4367517608807 1.61767774905781e-21 0.839140856433652 2.14206419096552e-18 miRNATAP -0.268607928479747 6.17604435079433e-20 NA NA NA hsa-miR-15a-5p CDK17 0.349521211668244 0.000770735998804736 -0.446838594295981 3.86782568298519e-07 MirTarget;miRNATAP -0.100794637194682 0.0162001197115672 NA NA NA hsa-miR-148a-3p CDK19 -0.748702855596996 3.93313343865641e-07 0.118030592068031 0.294061978811636 miRNAWalker2_validate;MirTarget;miRNATAP -0.236428879384442 4.30907764913248e-11 NA NA NA hsa-miR-192-3p CDK19 -0.6401165114007 0.000266272092403814 0.118030592068031 0.294061978811636 mirMAP -0.109047031522514 0.000413902548082403 NA NA NA hsa-miR-194-5p CDK19 -0.292530160992458 0.0996141384876663 0.118030592068031 0.294061978811636 MirTarget;miRNATAP -0.113222056710999 0.000224919940688928 NA NA NA hsa-miR-148a-3p CDK5R1 -0.748702855596996 3.93313343865641e-07 1.08475307136185 2.13782053288791e-11 MirTarget;miRNATAP -0.168450901534998 0.00186813487415298 NA NA NA hsa-miR-27b-3p CDK5R1 -0.823491817819754 9.20935302746823e-14 1.08475307136185 2.13782053288791e-11 miRNATAP -0.252961308884038 0.000387463806986018 NA NA NA hsa-miR-182-5p CDK6 1.96601340710222 4.39326175603633e-09 -0.306731100792328 0.220566158555725 mirMAP -0.10653370302744 0.0027913600827753 NA NA NA hsa-miR-20a-5p CDK6 0.854326758727003 5.04256669663285e-07 -0.306731100792328 0.220566158555725 mirMAP -0.336108073900107 1.71022894952879e-06 NA NA NA hsa-miR-20b-5p CDK6 0.457668023910379 0.0285865211936156 -0.306731100792328 0.220566158555725 mirMAP -0.209722611209641 0.000304623744169473 26166554 The transfection of miR-20b into EJ cells induced G1 phase cell cycle arrest via the decreased expression of cyclin D1 CDK2 and CDK6 without affecting another G1 phase cell cycle regulator cyclin E bladder cancer hsa-miR-224-3p CDK6 1.40770116795301 1.31426607144612e-08 -0.306731100792328 0.220566158555725 mirMAP -0.144127925871375 0.00324265854216547 NA NA NA hsa-miR-30c-5p CDK6 -0.432111642767632 0.000159764714931007 -0.306731100792328 0.220566158555725 mirMAP -0.216218252196024 0.0429693986026234 NA NA NA hsa-miR-132-3p CDK9 0.323796239695997 0.00272093067935091 -0.537402036038928 4.62631522084404e-10 mirMAP -0.140155897852595 0.000410755928615713 NA NA NA hsa-miR-146b-5p CDKN1A 0.419719546795449 0.0457375823220155 -0.769088197669944 5.80039048047741e-05 miRNAWalker2_validate -0.153153076910721 0.000589578943698456 27602131 During the search for potential targets of miR-146b in ATC p21 also known as p21Waf1/Cip1 or CDKN1A was noted for its role in cell cycle progression and tumor pathogenesis progression thyroid cancer hsa-miR-20a-5p CDKN1A 0.854326758727003 5.04256669663285e-07 -0.769088197669944 5.80039048047741e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.281025701374886 1.92150921220327e-07 26012475 Using the poorly tumorigenic and TGF-β-sensitive FET cell line that expresses low miR-20a levels we first confirmed that miR-20a downmodulated CDKN1A expression both at mRNA and protein level through direct binding to its 3'-UTR; Moreover besides modulating CDKN1A miR-20a blocked TGF-β-induced transactivation of its promoter without affecting the post-receptor activation of Smad3/4 effectors directly; Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex colon cancer hsa-miR-503-5p CDKN1A 0.191949282338049 0.268420664548092 -0.769088197669944 5.80039048047741e-05 miRNAWalker2_validate;miRTarBase -0.140430121948101 0.00973159792553366 NA NA NA hsa-miR-181a-5p CDKN1B 0.250113435902954 0.0551933249319293 -0.231452033928625 0.00482071055692889 miRNAWalker2_validate;miRTarBase -0.134068475887496 1.13890102336643e-05 NA NA NA hsa-miR-221-3p CDKN1B 1.12244756358612 3.48370308238012e-13 -0.231452033928625 0.00482071055692889 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.153438831523776 5.56071406720925e-10 20146005;23637992;19953484;23939688;19126397;23967190;17569667;22992757;17721077;20461750 Matched HCC and adjacent non-cancerous samples were assayed for the expression of miR-221 and three G1/S transition inhibitors: p27Kip1 p21WAF1/Cip1and TGF-β1 by in situ hybridization and immunohistochemistry respectively; Real time qRT-PCR was used to investigate miR-221 and p27Kip1 transcripts in different clinical stages; In result miR-221 and TGF-β1 are frequently up-regulated in HCC while p27Kip1 and p21WAF1/Cip1 proteins are frequently down-regulated; In conclusion miR-221 is important in tumorigenesis of HCC possibly by specifically down-regulating p27Kip1 a cell-cycle inhibitor;miR-221 knockdown not only blocked cell cycle progression induced cell apoptosis and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27kip1;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;A Slug/miR-221 network has been suggested linking miR-221 activity with the downregulation of a Slug repressor leading to Slug/miR-221 upregulation and p27Kip1 downregulation; Interference with this process can be achieved using antisense miRNA antagomiR molecules targeting miR-221 inducing the downregulation of Slug and the upregulation of p27Kip1;Moreover a series of functional assays demonstrated that mir-221 could directly inhibit cKit p27Kip1 and possibly other pivotal proteins in melanoma;Additionally the PDGF-dependent increase in cell proliferation appears to be mediated by inhibition of a specific target of miR-221 and down-regulation of p27Kip1;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;Peptide nucleic acids targeting miR 221 modulate p27Kip1 expression in breast cancer MDA MB 231 cells; Targeting miR-221 by PNA resulted in i lowering of the hybridization levels of miR-221 measured by RT-qPCR ii upregulation of p27Kip1 gene expression measured by RT-qPCR and western blot analysis;Antagonism of either microRNA 221 or 222 in glioblastoma cells also caused an increase in p27Kip1 levels and enhanced expression of the luciferase reporter gene fused to the p27Kip1 3'UTR;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression staging;tumorigenesis;progression;;;;;;;;poor survival liver cancer;breast cancer;glioblastoma;breast cancer;melanoma;pancreatic cancer;prostate cancer;breast cancer;glioblastoma;ovarian cancer hsa-miR-222-3p CDKN1B 1.08574156066353 1.76407192348131e-11 -0.231452033928625 0.00482071055692889 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.140430207935426 3.56247154847449e-09 19953484;26912358;24895988;24137356;17569667;27282281;20461750 Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;Besides microvesicle marker characterization we evidenced that miR-222 exosomal expression mostly reflected its abundance in the cells of origin correctly paralleled by repression of its target genes such as p27Kip1 and induction of the PI3K/AKT pathway thus confirming its functional implication in cancer;MiR-222 plays an important role in the tumorigenesis of CC possibly by specifically down-regulating p27Kip1 and PTEN;miR 222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27kip1; miR-222 upregulation induced an enhancement of ovarian cancer cell proliferation potential possibly by downregulating its target P27Kip1; A bioinformatic analysis showed that the 3'-UTR of the P27Kip1 mRNA contained a highly-conserved putative miR-222 binding site; Luciferase reporter assays demonstrated that P27Kip1 was a direct target of miR-222; Consistently there was an inverse correlation between the P27Kip1 and miR-222 expression levels in the ovarian cancer cell lines and tissues;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;miR 222 confers the resistance of breast cancer cells to Adriamycin through suppression of p27kip1 expression; Immunofluorescence showed that miR-222 altered the subcellular location of p27kip1 in nucleus; The results showed that downregulation of miR-222 in MCF-7/Adr increased sensitivity to Adr and Adr-induced apoptosis and arrested the cells in G1 phase accompanied by more expressions of p27kip1 especially in nucleus; Taken together the results found that miR-222 induced Adr-resistance at least in part via suppressing p27kip1 expression and altering its subcellular localization and miR-222 inhibitors could reverse Adr-resistance of breast cancer cells;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression ;;tumorigenesis;;;drug resistance;poor survival glioblastoma;melanoma;cervical and endocervical cancer;ovarian cancer;prostate cancer;breast cancer;ovarian cancer hsa-miR-34a-5p CDKN1C 1.03694231790865 5.74864019540594e-14 -0.792468549580106 0.00223062723240569 miRNATAP -0.21687755974993 0.0153510990836739 NA NA NA hsa-miR-215-5p CDKN2A -0.981544773246509 3.14452272477156e-05 3.99778785884008 5.9152054899506e-37 miRNAWalker2_validate -0.173889591255305 0.0139599519993765 NA NA NA hsa-miR-455-3p CDKN2A -1.3998033821095 5.72010709806871e-17 3.99778785884008 5.9152054899506e-37 miRNAWalker2_validate -0.424733120907109 9.98850494017421e-06 NA NA NA hsa-miR-451a CDKN2B -2.1025161666445 6.82555767537341e-17 1.37191742600332 3.8601745589837e-15 MirTarget -0.162386705840671 1.05027558906518e-06 NA NA NA hsa-miR-192-5p CDKN2D -0.50188499512787 0.00344713341196035 0.290727219677442 0.00930996537957609 miRNAWalker2_validate -0.138849298331389 1.02446714787693e-05 NA NA NA hsa-miR-215-5p CDKN3 -0.981544773246509 3.14452272477156e-05 4.30293915974951 2.17117758910494e-57 miRNAWalker2_validate -0.138542545444261 0.0298703297010969 NA NA NA hsa-miR-127-3p CDRT1 -1.0751374948053 2.19322892330221e-05 1.63595015467407 4.5809516315446e-06 miRanda -0.237202183364509 0.000542635011649973 NA NA NA hsa-miR-146b-5p CDS1 0.419719546795449 0.0457375823220155 -0.320537686923673 0.401665556750745 miRanda;miRNATAP -0.218626877739521 0.0136121382933578 NA NA NA hsa-miR-148a-3p CDS1 -0.748702855596996 3.93313343865641e-07 -0.320537686923673 0.401665556750745 miRNATAP -0.62382426469952 4.34120367054976e-07 NA NA NA hsa-miR-27b-3p CDYL -0.823491817819754 9.20935302746823e-14 0.406635443252195 1.20554482771922e-07 miRNATAP -0.110850847875399 0.000886736113506495 NA NA NA hsa-miR-29c-3p CECR6 -1.4367517608807 1.61767774905781e-21 0.392226039618319 0.0399877472539567 mirMAP -0.173678440003256 0.00312050475608688 NA NA NA hsa-miR-30c-5p CECR6 -0.432111642767632 0.000159764714931007 0.392226039618319 0.0399877472539567 mirMAP;miRNATAP -0.207434168073399 0.0108791333199492 NA NA NA hsa-miR-192-3p CELF2 -0.6401165114007 0.000266272092403814 -0.739701752181153 7.71802060056074e-05 mirMAP;miRNATAP -0.428402902137407 1.20501896308748e-17 NA NA NA hsa-miR-20a-5p CELF2 0.854326758727003 5.04256669663285e-07 -0.739701752181153 7.71802060056074e-05 miRNATAP -0.224526709174511 2.33049039740751e-05 NA NA NA hsa-miR-34a-5p CELF2 1.03694231790865 5.74864019540594e-14 -0.739701752181153 7.71802060056074e-05 miRNATAP -0.207924368139257 0.00129571652073981 NA NA NA hsa-miR-455-5p CELF2 -0.270546034117157 0.0581320703577731 -0.739701752181153 7.71802060056074e-05 miRanda -0.372902647191655 4.3279606982038e-09 NA NA NA hsa-miR-148a-3p CELSR1 -0.748702855596996 3.93313343865641e-07 0.364471201671942 0.107126693908784 MirTarget -0.208015418033919 0.00486931864679582 NA NA NA hsa-miR-30b-5p CELSR3 -0.54056186708617 2.44688760798341e-05 3.20386657067565 1.42274406912876e-34 MirTarget -0.361098055651926 0.000794968384611379 NA NA NA hsa-miR-30c-5p CELSR3 -0.432111642767632 0.000159764714931007 3.20386657067565 1.42274406912876e-34 miRNAWalker2_validate;MirTarget;miRNATAP -0.325750696056631 0.00723694979019419 NA NA NA hsa-miR-30e-5p CELSR3 -0.627815042856657 3.02205690184908e-10 3.20386657067565 1.42274406912876e-34 MirTarget -0.399465107085684 0.00366922272415224 NA NA NA hsa-miR-192-5p CENPA -0.50188499512787 0.00344713341196035 3.96964552344392 5.7307306371057e-43 miRNAWalker2_validate -0.210866144790898 0.0208834714440388 NA NA NA hsa-miR-215-5p CENPA -0.981544773246509 3.14452272477156e-05 3.96964552344392 5.7307306371057e-43 miRNAWalker2_validate -0.138753993272178 0.0354579457272508 NA NA NA hsa-miR-192-5p CENPE -0.50188499512787 0.00344713341196035 3.34412617436963 8.3241907160162e-43 miRNAWalker2_validate -0.168885819050718 0.0283464029127194 NA NA NA hsa-miR-215-5p CENPE -0.981544773246509 3.14452272477156e-05 3.34412617436963 8.3241907160162e-43 miRNAWalker2_validate -0.126946531982951 0.0224966317220544 NA NA NA hsa-miR-192-5p CENPF -0.50188499512787 0.00344713341196035 3.79236503476937 1.25674067170883e-49 miRNAWalker2_validate -0.180264560459754 0.0284939797929093 NA NA NA hsa-miR-215-5p CENPF -0.981544773246509 3.14452272477156e-05 3.79236503476937 1.25674067170883e-49 miRNAWalker2_validate -0.140726840124412 0.0178709155776648 NA NA NA hsa-miR-192-5p CENPI -0.50188499512787 0.00344713341196035 3.2049585053102 7.34752072975322e-29 miRNAWalker2_validate -0.226734285653858 0.009599189452 NA NA NA hsa-miR-215-5p CENPI -0.981544773246509 3.14452272477156e-05 3.2049585053102 7.34752072975322e-29 miRNAWalker2_validate -0.213094879809157 0.00072728512780691 NA NA NA hsa-miR-215-5p CENPK -0.981544773246509 3.14452272477156e-05 2.91476240486479 2.54766199959213e-30 miRNAWalker2_validate -0.140823009909813 0.0122988638462114 NA NA NA hsa-miR-148a-3p CENPP -0.748702855596996 3.93313343865641e-07 1.58562892488644 4.26649488498792e-22 mirMAP -0.152643938238212 0.00690454136350145 NA NA NA hsa-miR-192-3p CENPP -0.6401165114007 0.000266272092403814 1.58562892488644 4.26649488498792e-22 mirMAP -0.133120090131108 0.00531580498870934 NA NA NA hsa-miR-505-5p CENPP -0.768282569967001 1.14662846595407e-05 1.58562892488644 4.26649488498792e-22 mirMAP -0.134899210944819 0.00469161607826815 NA NA NA hsa-miR-181b-5p CEP120 0.488256489401108 0.00105321129419701 -0.38529251765269 1.61409004225275e-05 MirTarget -0.107221869943166 0.000243460725969443 NA NA NA hsa-miR-30b-5p CEP152 -0.54056186708617 2.44688760798341e-05 1.40026752029813 4.88255682520073e-17 miRNAWalker2_validate -0.199505452645697 0.00240339146389961 NA NA NA hsa-miR-194-5p CEP170 -0.292530160992458 0.0996141384876663 0.261439428412392 0.0283739958407734 miRNATAP -0.194215530287589 1.59059568723414e-09 NA NA NA hsa-miR-30b-5p CEP350 -0.54056186708617 2.44688760798341e-05 0.488306436373169 6.10029026629057e-08 MirTarget;miRNATAP -0.142400269966468 3.45950866492249e-05 NA NA NA hsa-miR-148a-3p CEP55 -0.748702855596996 3.93313343865641e-07 2.874986535696 2.48808404875451e-31 MirTarget -0.761706377152175 6.27881131213199e-20 NA NA NA hsa-miR-192-5p CEP55 -0.50188499512787 0.00344713341196035 2.874986535696 2.48808404875451e-31 miRNAWalker2_validate -0.39326043275467 1.41666164296471e-07 NA NA NA hsa-miR-215-5p CEP55 -0.981544773246509 3.14452272477156e-05 2.874986535696 2.48808404875451e-31 miRNAWalker2_validate -0.189425885032756 0.000507286227894504 NA NA NA hsa-miR-29c-3p CEP68 -1.4367517608807 1.61767774905781e-21 0.644038069041604 5.15553965753215e-16 miRNAWalker2_validate;MirTarget -0.115594740758264 3.91037436321457e-06 NA NA NA hsa-miR-30b-5p CEP76 -0.54056186708617 2.44688760798341e-05 -0.326177023241967 0.00214304718435848 MirTarget -0.17152816027109 1.86445869486067e-05 NA NA NA hsa-miR-20a-5p CEP97 0.854326758727003 5.04256669663285e-07 0.291198246303295 0.0718443054357866 MirTarget;miRNATAP -0.122187549811516 0.00766093527928555 NA NA NA hsa-miR-20a-5p CERCAM 0.854326758727003 5.04256669663285e-07 -0.11834200381201 0.648161793551643 MirTarget -0.189904373601208 0.00968204082674771 NA NA NA hsa-miR-146a-5p CFH -0.742958238440575 0.000765983177482633 -0.878690229382148 2.91880585804383e-05 miRNAWalker2_validate;miRTarBase -0.109139574250413 0.0192057006585646 NA NA NA hsa-miR-222-3p CFHR5 1.08574156066353 1.76407192348131e-11 -1.75145602133745 0.000267176560995415 MirTarget -0.907799998189017 8.35565496514001e-11 NA NA NA hsa-miR-181a-5p CFI 0.250113435902954 0.0551933249319293 -1.67954631248812 1.7499902529916e-19 miRNAWalker2_validate -0.388192373890316 7.51072622553607e-08 NA NA NA hsa-miR-132-3p CFL2 0.323796239695997 0.00272093067935091 -1.18046432826413 1.44423082204062e-19 MirTarget;miRNATAP -0.416955984946849 5.21885347176423e-12 NA NA NA hsa-miR-19b-3p CFL2 0.601279551368824 0.00016685097085251 -1.18046432826413 1.44423082204062e-19 MirTarget -0.146954804508412 0.000377110030518428 NA NA NA hsa-miR-20a-5p CFL2 0.854326758727003 5.04256669663285e-07 -1.18046432826413 1.44423082204062e-19 MirTarget;miRNATAP -0.161827805421383 2.54251193863767e-05 NA NA NA hsa-miR-455-5p CFLAR -0.270546034117157 0.0581320703577731 -0.332671102072829 2.00694636367654e-06 miRanda -0.110213584277723 3.95957481119902e-06 NA NA NA hsa-miR-15a-5p CHAC1 0.349521211668244 0.000770735998804736 -0.275879940251682 0.332731765484065 miRNATAP -0.330787721378195 0.0136898577191468 NA NA NA hsa-miR-15a-5p CHD9 0.349521211668244 0.000770735998804736 -0.511590175184198 2.71332522550186e-05 miRNATAP -0.269376510553751 2.62907206032945e-06 NA NA NA hsa-miR-181a-5p CHD9 0.250113435902954 0.0551933249319293 -0.511590175184198 2.71332522550186e-05 miRNATAP -0.167085178881312 0.000274128644014403 NA NA NA hsa-miR-181b-5p CHD9 0.488256489401108 0.00105321129419701 -0.511590175184198 2.71332522550186e-05 miRNATAP -0.154636621343966 0.000106459019244057 NA NA NA hsa-miR-20a-5p CHD9 0.854326758727003 5.04256669663285e-07 -0.511590175184198 2.71332522550186e-05 MirTarget;miRNATAP -0.236626189894067 3.15411664380204e-12 NA NA NA hsa-miR-20b-5p CHD9 0.457668023910379 0.0285865211936156 -0.511590175184198 2.71332522550186e-05 MirTarget;miRNATAP -0.123191406199838 1.4365386027736e-05 NA NA NA hsa-miR-27b-3p CHKA -0.823491817819754 9.20935302746823e-14 1.03066945671527 4.50639789726118e-14 miRNATAP -0.174426485767567 0.00403524593117461 NA NA NA hsa-miR-30e-5p CHKA -0.627815042856657 3.02205690184908e-10 1.03066945671527 4.50639789726118e-14 MirTarget -0.203034905860909 0.00283967779860527 NA NA NA hsa-miR-17-3p CHM 0.410352776142368 0.00422200500748636 -0.144900743999015 0.173677209845794 MirTarget -0.184918771513666 2.18191347222478e-07 NA NA NA hsa-miR-455-5p CHM -0.270546034117157 0.0581320703577731 -0.144900743999015 0.173677209845794 miRanda -0.124618712934421 0.000588706929424748 NA NA NA hsa-miR-192-3p CHML -0.6401165114007 0.000266272092403814 1.36046818922419 4.56839592537351e-13 MirTarget -0.121560242353846 0.0231558102550994 NA NA NA hsa-miR-181a-5p CHMP1B 0.250113435902954 0.0551933249319293 -0.234526742527025 0.00393277321058343 MirTarget -0.107342318304637 0.000411067877692343 NA NA NA hsa-miR-455-5p CHRFAM7A -0.270546034117157 0.0581320703577731 0.768053302560379 0.00964557083077357 miRanda -0.293868312726318 0.00390097488852321 NA NA NA hsa-miR-30b-5p CHRM3 -0.54056186708617 2.44688760798341e-05 0.639825919544099 0.0558578477040502 mirMAP -0.473288309668257 0.00018196385099285 NA NA NA hsa-miR-148a-3p CHST1 -0.748702855596996 3.93313343865641e-07 0.685732737107354 0.00199386228629166 MirTarget -0.733860751670885 6.4615399196172e-27 NA NA NA hsa-miR-30e-5p CHST1 -0.627815042856657 3.02205690184908e-10 0.685732737107354 0.00199386228629166 MirTarget -0.463473330047621 1.46147860192723e-05 NA NA NA hsa-miR-455-3p CHST11 -1.3998033821095 5.72010709806871e-17 0.212129982459871 0.371243396667812 miRNATAP -0.367942113533476 1.99060708796954e-08 NA NA NA hsa-miR-192-5p CHST12 -0.50188499512787 0.00344713341196035 0.217162104581685 0.0165950178679844 miRNAWalker2_validate -0.22511938636416 4.12108652391851e-20 NA NA NA hsa-miR-192-3p CHST15 -0.6401165114007 0.000266272092403814 -0.153338445523413 0.30844723320558 miRNATAP -0.150239547566443 0.00028139968809516 NA NA NA hsa-miR-19b-3p CHST15 0.601279551368824 0.00016685097085251 -0.153338445523413 0.30844723320558 mirMAP -0.234572349225506 1.99873743713261e-07 NA NA NA hsa-miR-27b-3p CHST2 -0.823491817819754 9.20935302746823e-14 0.253750766454774 0.0776793157765737 miRNATAP -0.247383741863137 5.90487628803464e-05 NA NA NA hsa-miR-30e-5p CHST2 -0.627815042856657 3.02205690184908e-10 0.253750766454774 0.0776793157765737 MirTarget -0.19173573978975 0.00576527490627639 NA NA NA hsa-miR-148a-3p CHST3 -0.748702855596996 3.93313343865641e-07 -0.197541925922359 0.301297241668114 mirMAP -0.543542392297203 7.99217300956161e-20 NA NA NA hsa-miR-192-5p CHSY3 -0.50188499512787 0.00344713341196035 -1.1705830419215 8.35489202868046e-09 miRNAWalker2_validate -0.197495798803328 0.00073594034946924 NA NA NA hsa-miR-15a-5p CHUK 0.349521211668244 0.000770735998804736 -0.19932080126218 0.00863163957240649 miRNAWalker2_validate;miRTarBase;MirTarget -0.122536038974783 0.000565424625908096 NA NA NA hsa-miR-192-5p CIB2 -0.50188499512787 0.00344713341196035 1.05115223730211 8.5015227327244e-05 miRNAWalker2_validate -0.376172513964881 6.57490138733288e-07 NA NA NA hsa-miR-148a-3p CIITA -0.748702855596996 3.93313343865641e-07 0.267952742521313 0.180108388943748 mirMAP -0.264823270812163 4.50203150079269e-05 NA NA NA hsa-miR-194-5p CIITA -0.292530160992458 0.0996141384876663 0.267952742521313 0.180108388943748 mirMAP -0.372478282937465 3.52667264422411e-12 NA NA NA hsa-miR-20a-5p CIITA 0.854326758727003 5.04256669663285e-07 0.267952742521313 0.180108388943748 mirMAP -0.186755125497455 0.000942814576563259 NA NA NA hsa-miR-455-5p CIITA -0.270546034117157 0.0581320703577731 0.267952742521313 0.180108388943748 mirMAP -0.392492958682484 5.54051707276185e-09 NA NA NA hsa-miR-192-3p CILP -0.6401165114007 0.000266272092403814 -2.62579341294171 3.57676119994075e-18 MirTarget -0.247827393942324 0.00443781794121967 NA NA NA hsa-miR-148a-3p CIT -0.748702855596996 3.93313343865641e-07 0.474922759349472 0.00990742942099617 miRNATAP -0.151727650508733 0.0118981318787957 NA NA NA hsa-miR-27b-3p CIT -0.823491817819754 9.20935302746823e-14 0.474922759349472 0.00990742942099617 miRNATAP -0.170365755132697 0.0323960193359166 NA NA NA hsa-miR-192-5p CKAP4 -0.50188499512787 0.00344713341196035 0.831324304717088 2.24371704954539e-11 miRNAWalker2_validate -0.154306803181703 1.65048180727524e-05 NA NA NA hsa-miR-27b-3p CKAP4 -0.823491817819754 9.20935302746823e-14 0.831324304717088 2.24371704954539e-11 miRNATAP -0.206026894566588 0.000160215157075604 NA NA NA hsa-miR-30c-5p CKAP4 -0.432111642767632 0.000159764714931007 0.831324304717088 2.24371704954539e-11 miRNAWalker2_validate -0.172897536250794 0.00139559869212013 NA NA NA hsa-miR-15a-5p CLCN3 0.349521211668244 0.000770735998804736 -0.341384908537399 0.0121834530701077 miRTarBase -0.290424531311434 5.13383107984748e-06 NA NA NA hsa-miR-17-3p CLCN3 0.410352776142368 0.00422200500748636 -0.341384908537399 0.0121834530701077 mirMAP -0.27445997349951 1.67576303018246e-09 NA NA NA hsa-miR-181a-5p CLCN5 0.250113435902954 0.0551933249319293 -0.778462528596492 1.09010470162582e-08 mirMAP -0.152755188274904 0.00326240424526109 NA NA NA hsa-miR-181b-5p CLCN5 0.488256489401108 0.00105321129419701 -0.778462528596492 1.09010470162582e-08 mirMAP -0.145186839362961 0.00129240986340382 NA NA NA hsa-miR-21-5p CLCN5 1.51084295924322 1.54551622173259e-34 -0.778462528596492 1.09010470162582e-08 miRNAWalker2_validate;mirMAP -0.326165630569137 4.23073780387319e-11 NA NA NA hsa-miR-181a-5p CLCN6 0.250113435902954 0.0551933249319293 -0.000861885614773961 0.99311005057538 mirMAP -0.118455952447118 0.00146078478933429 NA NA NA hsa-miR-146b-5p CLDN10 0.419719546795449 0.0457375823220155 -5.17559899812778 4.22957526364631e-22 miRanda -0.25810791569571 0.0492628313879522 NA NA NA hsa-miR-15a-5p CLDN12 0.349521211668244 0.000770735998804736 -0.374004014225565 0.00034798002039704 MirTarget;miRNATAP -0.106787509854349 0.0310085999912548 NA NA NA hsa-miR-29c-3p CLDN19 -1.4367517608807 1.61767774905781e-21 0.664547149654215 0.101293695037712 mirMAP -0.498794196274358 5.94041327793337e-05 NA NA NA hsa-miR-222-3p CLDN23 1.08574156066353 1.76407192348131e-11 -0.482843874483971 0.000451675511590809 miRNAWalker2_validate -0.159785671200253 8.25946957065681e-05 NA NA NA hsa-miR-192-3p CLEC2B -0.6401165114007 0.000266272092403814 -0.829412613549136 6.12520776004944e-07 MirTarget -0.264447295900266 7.8054508743312e-09 NA NA NA hsa-miR-29c-3p CLEC2L -1.4367517608807 1.61767774905781e-21 1.62385264949693 0.000126498035061922 MirTarget;miRNATAP -0.689162182335824 1.09033083844845e-07 NA NA NA hsa-miR-455-5p CLEC5A -0.270546034117157 0.0581320703577731 -0.596046626685126 0.055346694069956 miRanda -0.328935749104071 0.00200558742005996 NA NA NA hsa-miR-455-5p CLEC7A -0.270546034117157 0.0581320703577731 -1.12693204745581 2.92876149157236e-07 miRanda -0.394422519750267 1.68829714955666e-07 NA NA NA hsa-miR-192-5p CLIC1 -0.50188499512787 0.00344713341196035 0.769904485927027 1.7810853875854e-08 miRNAWalker2_validate -0.233527854498628 1.60324341964638e-09 NA NA NA hsa-miR-146b-5p CLIC5 0.419719546795449 0.0457375823220155 0.654179205260766 0.00496444099844159 miRanda -0.148723820785143 0.00601948197770975 NA NA NA hsa-miR-455-5p CLIC5 -0.270546034117157 0.0581320703577731 0.654179205260766 0.00496444099844159 miRanda -0.388160943786719 9.51484674548403e-07 NA NA NA hsa-miR-20a-5p CLIC6 0.854326758727003 5.04256669663285e-07 -3.64273918141813 1.0632287091366e-18 mirMAP -0.731639335918485 1.11738721848211e-09 NA NA NA hsa-miR-181a-5p CLIP1 0.250113435902954 0.0551933249319293 -0.277457644294426 0.00917645327427696 MirTarget;miRNATAP -0.167513297439869 2.46472331933494e-05 NA NA NA hsa-miR-181b-5p CLIP1 0.488256489401108 0.00105321129419701 -0.277457644294426 0.00917645327427696 MirTarget;miRNATAP -0.149344504492455 1.5223432806567e-05 NA NA NA hsa-miR-192-5p CLIP4 -0.50188499512787 0.00344713341196035 -0.223789354668674 0.439544374325892 miRNAWalker2_validate -0.383858187296679 2.32080371754578e-06 NA NA NA hsa-miR-194-5p CLIP4 -0.292530160992458 0.0996141384876663 -0.223789354668674 0.439544374325892 MirTarget -0.391504035835542 6.40553920124539e-07 NA NA NA hsa-miR-19b-3p CLIP4 0.601279551368824 0.00016685097085251 -0.223789354668674 0.439544374325892 MirTarget;miRNATAP -0.297551461288584 0.000686358663159669 NA NA NA hsa-miR-20a-5p CLIP4 0.854326758727003 5.04256669663285e-07 -0.223789354668674 0.439544374325892 MirTarget -0.302741686946667 0.000208432298227346 NA NA NA hsa-miR-215-5p CLIP4 -0.981544773246509 3.14452272477156e-05 -0.223789354668674 0.439544374325892 miRNAWalker2_validate -0.250459312093365 2.08568780947113e-05 NA NA NA hsa-miR-27b-3p CLK2 -0.823491817819754 9.20935302746823e-14 0.920082317853538 3.42213492570439e-25 miRNATAP -0.100574962788244 0.0130853716960662 NA NA NA hsa-miR-29c-3p CLK2 -1.4367517608807 1.61767774905781e-21 0.920082317853538 3.42213492570439e-25 MirTarget;miRNATAP -0.192965691236652 8.67924733012006e-12 NA NA NA hsa-miR-221-3p CLN8 1.12244756358612 3.48370308238012e-13 -0.897397341277566 2.6962794902646e-12 mirMAP -0.139109615720654 0.000570745837446507 NA NA NA hsa-miR-146b-5p CLOCK 0.419719546795449 0.0457375823220155 -0.52744295488734 0.00745405676073919 mirMAP -0.18544237654454 4.68673151334468e-05 NA NA NA hsa-miR-15a-5p CLOCK 0.349521211668244 0.000770735998804736 -0.52744295488734 0.00745405676073919 MirTarget -0.371225353514772 6.10486234664708e-05 NA NA NA hsa-miR-181a-5p CLOCK 0.250113435902954 0.0551933249319293 -0.52744295488734 0.00745405676073919 mirMAP -0.20099222834149 0.00672120277084073 NA NA NA hsa-miR-181b-5p CLOCK 0.488256489401108 0.00105321129419701 -0.52744295488734 0.00745405676073919 mirMAP -0.13136442574215 0.0421021972963017 NA NA NA hsa-miR-19b-3p CLOCK 0.601279551368824 0.00016685097085251 -0.52744295488734 0.00745405676073919 MirTarget -0.242674743771583 4.79875047021731e-05 NA NA NA hsa-miR-20a-5p CLOCK 0.854326758727003 5.04256669663285e-07 -0.52744295488734 0.00745405676073919 MirTarget -0.283818732522307 2.93587035640901e-07 NA NA NA hsa-miR-21-5p CLOCK 1.51084295924322 1.54551622173259e-34 -0.52744295488734 0.00745405676073919 miRNAWalker2_validate -0.260389633076203 0.000290149185096459 NA NA NA hsa-miR-30b-5p CLOCK -0.54056186708617 2.44688760798341e-05 -0.52744295488734 0.00745405676073919 MirTarget -0.180249120709271 0.016200321814959 NA NA NA hsa-miR-34a-5p CLOCK 1.03694231790865 5.74864019540594e-14 -0.52744295488734 0.00745405676073919 MirTarget -0.156168795054685 0.0215545193543451 NA NA NA hsa-miR-455-5p CLOCK -0.270546034117157 0.0581320703577731 -0.52744295488734 0.00745405676073919 MirTarget -0.324317745464245 1.30082672463026e-06 NA NA NA hsa-miR-192-5p CLSPN -0.50188499512787 0.00344713341196035 2.7969110828425 3.03477840103e-20 miRNAWalker2_validate -0.298993623901868 0.000906240962654405 NA NA NA hsa-miR-215-5p CLSPN -0.981544773246509 3.14452272477156e-05 2.7969110828425 3.03477840103e-20 miRNAWalker2_validate -0.13865453679748 0.033855451080362 NA NA NA hsa-miR-192-5p CLSTN1 -0.50188499512787 0.00344713341196035 0.327988364183752 0.0351370589579253 miRNAWalker2_validate -0.336638831802042 3.36297746483766e-15 NA NA NA hsa-miR-215-5p CLSTN1 -0.981544773246509 3.14452272477156e-05 0.327988364183752 0.0351370589579253 miRNAWalker2_validate -0.100559598650288 0.00158707138418194 NA NA NA hsa-miR-455-3p CLSTN1 -1.3998033821095 5.72010709806871e-17 0.327988364183752 0.0351370589579253 miRNAWalker2_validate -0.213749520079061 7.74722274048334e-07 NA NA NA hsa-miR-30b-5p CLTC -0.54056186708617 2.44688760798341e-05 0.162133171144898 0.0191337762970226 mirMAP -0.163393682300171 1.67003484901756e-10 NA NA NA hsa-miR-34a-5p CMAS 1.03694231790865 5.74864019540594e-14 -0.295659821413277 0.000605521731225176 miRNAWalker2_validate -0.106017608327963 0.000333773541921837 NA NA NA hsa-miR-30c-5p CMC1 -0.432111642767632 0.000159764714931007 0.291827935225109 0.00196527149345877 mirMAP -0.154552190930185 0.000112182847826543 NA NA NA hsa-miR-15a-5p CMPK1 0.349521211668244 0.000770735998804736 -0.676924575484083 5.30937933904552e-18 miRNATAP -0.19300387167312 3.45505973020804e-07 NA NA NA hsa-miR-20a-5p CMPK1 0.854326758727003 5.04256669663285e-07 -0.676924575484083 5.30937933904552e-18 MirTarget;miRNATAP -0.151343219588845 1.7954021975112e-11 NA NA NA hsa-miR-455-5p CMPK2 -0.270546034117157 0.0581320703577731 -0.614376262866122 0.00215021044104904 miRanda -0.211661178340909 0.00207231985935241 NA NA NA hsa-miR-20a-5p CNDP1 0.854326758727003 5.04256669663285e-07 -6.38507387239177 1.75288227225597e-27 mirMAP -0.706549117006544 6.76377547523147e-05 NA NA NA hsa-miR-148a-3p CNIH4 -0.748702855596996 3.93313343865641e-07 1.00667194671376 1.24728003967923e-20 MirTarget -0.10088285082769 0.00643146069475781 NA NA NA hsa-miR-181a-5p CNKSR2 0.250113435902954 0.0551933249319293 -0.547020289576205 0.157714486315915 MirTarget;miRNATAP -0.565645313867427 9.19601730083696e-05 NA NA NA hsa-miR-181b-5p CNKSR2 0.488256489401108 0.00105321129419701 -0.547020289576205 0.157714486315915 MirTarget;miRNATAP -0.691635497149149 2.88603014926427e-08 NA NA NA hsa-miR-148a-3p CNN1 -0.748702855596996 3.93313343865641e-07 0.406994515021795 0.0928241685509811 miRNATAP -0.497670787813982 1.39514602371003e-10 NA NA NA hsa-miR-15a-5p CNN1 0.349521211668244 0.000770735998804736 0.406994515021795 0.0928241685509811 miRNATAP -0.410440640061199 0.000307006298502032 NA NA NA hsa-miR-652-3p CNN3 0.135945800164278 0.391695970197646 0.000263645439876115 0.998162153700641 miRNAWalker2_validate -0.104857970880803 0.00282161082476119 NA NA NA hsa-miR-181a-5p CNNM2 0.250113435902954 0.0551933249319293 0.0459983088368134 0.648766534465195 miRNATAP -0.180023419047011 1.46302665210059e-06 NA NA NA hsa-miR-181b-5p CNNM2 0.488256489401108 0.00105321129419701 0.0459983088368134 0.648766534465195 miRNATAP -0.179090615638109 3.16048440845905e-08 NA NA NA hsa-miR-30e-5p CNOT6 -0.627815042856657 3.02205690184908e-10 0.531193574530853 1.98771174981903e-08 MirTarget -0.174525669815111 0.000157526991082922 NA NA NA hsa-miR-455-3p CNOT6 -1.3998033821095 5.72010709806871e-17 0.531193574530853 1.98771174981903e-08 PITA -0.128810979724166 1.36565760302483e-06 NA NA NA hsa-miR-19b-3p CNOT6L 0.601279551368824 0.00016685097085251 -0.534635871042822 7.73221918729952e-09 mirMAP -0.103751437589281 0.000264346340135498 NA NA NA hsa-miR-30b-5p CNR1 -0.54056186708617 2.44688760798341e-05 0.689541168623682 0.0674287187185731 mirMAP -0.304957387263502 0.0333055101453313 NA NA NA hsa-miR-221-3p CNRIP1 1.12244756358612 3.48370308238012e-13 -0.549923028422068 3.33463829283631e-05 miRNAWalker2_validate -0.120503414878902 0.00329937879148511 NA NA NA hsa-miR-181a-5p CNST 0.250113435902954 0.0551933249319293 -0.204837317225117 0.03828693885939 mirMAP -0.157699872073777 1.80929442886142e-05 NA NA NA hsa-miR-181b-5p CNST 0.488256489401108 0.00105321129419701 -0.204837317225117 0.03828693885939 mirMAP -0.178641505069534 1.83051666229557e-08 NA NA NA hsa-miR-146b-5p CNTFR 0.419719546795449 0.0457375823220155 -3.51076939120689 5.09275920906821e-11 miRNATAP -0.264771734273822 0.0374148420628102 NA NA NA hsa-miR-21-5p CNTFR 1.51084295924322 1.54551622173259e-34 -3.51076939120689 5.09275920906821e-11 miRNATAP -1.10448148913803 2.07872949243695e-08 NA NA NA hsa-miR-146b-5p CNTN1 0.419719546795449 0.0457375823220155 -2.31898322380772 8.24976131487461e-08 miRanda -0.230454935707639 0.0238914748685569 NA NA NA hsa-miR-148a-3p CNTN4 -0.748702855596996 3.93313343865641e-07 -2.23654576737969 6.05144113270082e-19 miRNATAP -0.267873351717936 0.00180831931684552 NA NA NA hsa-miR-181a-5p CNTNAP3 0.250113435902954 0.0551933249319293 0.106558723996186 0.742851881030026 MirTarget -0.284580688460938 0.019560126063906 NA NA NA hsa-miR-181b-5p CNTNAP3 0.488256489401108 0.00105321129419701 0.106558723996186 0.742851881030026 MirTarget -0.340083445890052 0.00129626018763495 NA NA NA hsa-miR-20a-5p CNTNAP3 0.854326758727003 5.04256669663285e-07 0.106558723996186 0.742851881030026 MirTarget -0.362604672355679 7.34184730089002e-05 NA NA NA hsa-miR-215-5p CNTNAP3 -0.981544773246509 3.14452272477156e-05 0.106558723996186 0.742851881030026 miRNAWalker2_validate -0.1893050496293 0.00436286266103583 NA NA NA hsa-miR-181a-5p COBL 0.250113435902954 0.0551933249319293 -0.625889423404631 0.000231830653158842 mirMAP -0.15358908238588 0.0168185115173517 NA NA NA hsa-miR-181b-5p COBL 0.488256489401108 0.00105321129419701 -0.625889423404631 0.000231830653158842 mirMAP -0.168685018771801 0.00248953182296669 NA NA NA hsa-miR-21-5p COBLL1 1.51084295924322 1.54551622173259e-34 -1.47196788797961 8.44363885667744e-17 miRNAWalker2_validate -0.802903087494741 1.14645324287371e-39 NA NA NA hsa-miR-455-5p COG5 -0.270546034117157 0.0581320703577731 0.471194651110495 9.73196559946646e-09 miRanda -0.109930218098181 0.000107106804030049 NA NA NA hsa-miR-29c-3p COL11A1 -1.4367517608807 1.61767774905781e-21 1.54551268520343 0.000618478933133262 MirTarget;miRNATAP -0.293538109336037 0.0360454968816281 NA NA NA hsa-miR-455-3p COL11A1 -1.3998033821095 5.72010709806871e-17 1.54551268520343 0.000618478933133262 MirTarget;PITA -0.758640755066561 1.38013331414381e-09 NA NA NA hsa-miR-15a-5p COL12A1 0.349521211668244 0.000770735998804736 -0.132213117983103 0.570362613274865 MirTarget;miRNATAP -0.437667227253736 5.96515706718496e-05 NA NA NA hsa-miR-17-3p COL12A1 0.410352776142368 0.00422200500748636 -0.132213117983103 0.570362613274865 MirTarget;miRNATAP -0.35616026263185 5.64589449417937e-06 NA NA NA hsa-miR-34a-5p COL12A1 1.03694231790865 5.74864019540594e-14 -0.132213117983103 0.570362613274865 MirTarget;miRNATAP -0.25473884489828 0.00140704114035112 NA NA NA hsa-miR-455-5p COL13A1 -0.270546034117157 0.0581320703577731 -0.0416877346972222 0.875067868990597 miRanda -0.277958064837517 0.00214332409656018 NA NA NA hsa-miR-29c-3p COL15A1 -1.4367517608807 1.61767774905781e-21 4.12846416187194 6.5314403333065e-56 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.363956732061469 8.02302671833046e-05 NA NA NA hsa-miR-455-5p COL15A1 -0.270546034117157 0.0581320703577731 4.12846416187194 6.5314403333065e-56 miRanda -0.365770582260791 0.000376239612357309 NA NA NA hsa-miR-20a-5p COL1A1 0.854326758727003 5.04256669663285e-07 0.826702197173396 0.00648724292232758 mirMAP -0.233621814946948 0.00679703428396713 NA NA NA hsa-miR-19b-3p COL1A2 0.601279551368824 0.00016685097085251 0.58018696776109 0.0267399288126224 MirTarget -0.171394957625176 0.0317489700467597 NA NA NA hsa-miR-29c-3p COL22A1 -1.4367517608807 1.61767774905781e-21 1.98323443832446 2.9366792216991e-05 miRNATAP -0.538071521740175 0.00024996698261773 NA NA NA hsa-miR-29c-3p COL2A1 -1.4367517608807 1.61767774905781e-21 2.31956756673828 0.000172146394351314 MirTarget;miRNATAP -1.27860412529072 8.10710043682058e-12 NA NA NA hsa-miR-455-3p COL3A1 -1.3998033821095 5.72010709806871e-17 -0.474803338347196 0.0877747183989073 miRNAWalker2_validate -0.362011875342883 2.90736869784078e-06 NA NA NA hsa-miR-148a-3p COL4A1 -0.748702855596996 3.93313343865641e-07 1.64595918385092 3.29766696573805e-22 miRNATAP -0.506696445918838 1.45523526380931e-19 NA NA NA hsa-miR-29c-3p COL4A1 -1.4367517608807 1.61767774905781e-21 1.64595918385092 3.29766696573805e-22 miRNAWalker2_validate;miRTarBase;miRNATAP -0.17365265771026 0.00160253083531795 NA NA NA hsa-miR-99a-5p COL4A1 -1.51481656384839 3.93230057259529e-14 1.64595918385092 3.29766696573805e-22 miRNAWalker2_validate -0.194902289048293 3.21789355543509e-06 NA NA NA hsa-miR-29c-3p COL4A2 -1.4367517608807 1.61767774905781e-21 1.44307871157488 7.7234079265155e-18 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.147672102686362 0.00605514035830943 NA NA NA hsa-miR-20a-5p COL4A3 0.854326758727003 5.04256669663285e-07 -0.92673315541801 0.00622463110440454 MirTarget;miRNATAP -0.275914518317586 0.00414348195590725 NA NA NA hsa-miR-15a-5p COL4A3BP 0.349521211668244 0.000770735998804736 -0.613641621350786 2.25554083957521e-14 MirTarget;miRNATAP -0.154591125014668 6.60249946854567e-05 NA NA NA hsa-miR-455-5p COL4A5 -0.270546034117157 0.0581320703577731 0.0635599577482339 0.881381174188716 miRanda -0.384902949893891 0.00826052024568226 NA NA NA hsa-miR-192-5p COL5A1 -0.50188499512787 0.00344713341196035 0.157717020532577 0.575064051526938 miRNATAP -0.69106442525522 1.23228181782937e-19 NA NA NA hsa-miR-29c-3p COL5A2 -1.4367517608807 1.61767774905781e-21 0.523957991319594 0.00488074596388077 MirTarget;miRNATAP -0.362723299809565 1.16833536591495e-10 NA NA NA hsa-miR-34a-5p COL5A2 1.03694231790865 5.74864019540594e-14 0.523957991319594 0.00488074596388077 MirTarget -0.219312055701001 0.000604452427539009 NA NA NA hsa-miR-455-5p COL5A2 -0.270546034117157 0.0581320703577731 0.523957991319594 0.00488074596388077 miRanda -0.185656765062945 0.00365335222424077 NA NA NA hsa-miR-146b-5p COL6A3 0.419719546795449 0.0457375823220155 0.169833671007575 0.432293683806163 miRanda -0.130033763284282 0.00943159485447041 NA NA NA hsa-miR-29c-3p COL7A1 -1.4367517608807 1.61767774905781e-21 2.91025161716558 1.66351001849965e-13 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.505811148582802 4.93285925553647e-05 NA NA NA hsa-miR-20a-5p COL8A2 0.854326758727003 5.04256669663285e-07 -0.974645375504798 0.000903968905923106 mirMAP -0.233448175322622 0.00524062360588325 NA NA NA hsa-miR-29c-3p COL9A1 -1.4367517608807 1.61767774905781e-21 2.78909880839119 5.63828792375664e-23 miRNATAP -0.435276338625617 1.77750960156697e-06 NA NA NA hsa-miR-29c-3p COMMD2 -1.4367517608807 1.61767774905781e-21 0.443110605839986 4.17243018155205e-10 MirTarget;miRNATAP -0.21355172046629 2.00453370009419e-24 NA NA NA hsa-miR-30e-5p COPS7B -0.627815042856657 3.02205690184908e-10 0.641973815480622 1.99581786116502e-17 mirMAP -0.166705613370727 9.13605508800424e-06 NA NA NA hsa-miR-19b-3p COQ10B 0.601279551368824 0.00016685097085251 -0.453143083702114 6.44780994602295e-09 MirTarget -0.119258224385585 5.26882731115623e-07 NA NA NA hsa-miR-146b-5p COQ9 0.419719546795449 0.0457375823220155 -0.616160145618963 9.35564819994638e-08 miRanda -0.100209631006924 0.000207194161528345 NA NA NA hsa-miR-192-5p CORO2B -0.50188499512787 0.00344713341196035 -0.778344883116467 0.00171267913877174 miRNAWalker2_validate -0.369365150680618 1.2148605675754e-07 NA NA NA hsa-miR-20a-5p CORO2B 0.854326758727003 5.04256669663285e-07 -0.778344883116467 0.00171267913877174 MirTarget;miRNATAP -0.173835235490549 0.013916097836381 NA NA NA hsa-miR-215-5p CORO2B -0.981544773246509 3.14452272477156e-05 -0.778344883116467 0.00171267913877174 miRNAWalker2_validate -0.122664335979348 0.0163753310208853 NA NA NA hsa-miR-29c-3p CORO6 -1.4367517608807 1.61767774905781e-21 0.843646567921258 6.48117727511291e-05 miRNATAP -0.156904894041618 0.0167196728623663 NA NA NA hsa-miR-455-5p CPA4 -0.270546034117157 0.0581320703577731 0.055606222876432 0.855985510169103 miRanda;miRNATAP -0.222731315399079 0.033833173964808 NA NA NA hsa-miR-148a-3p CPD -0.748702855596996 3.93313343865641e-07 0.599470550586786 4.65999718552314e-06 MirTarget;miRNATAP -0.141323955894331 0.00103892821521111 NA NA NA hsa-miR-27b-3p CPD -0.823491817819754 9.20935302746823e-14 0.599470550586786 4.65999718552314e-06 miRNATAP -0.244988094196586 1.47465599885245e-05 NA NA NA hsa-miR-30c-5p CPD -0.432111642767632 0.000159764714931007 0.599470550586786 4.65999718552314e-06 mirMAP -0.229045027025591 4.29479904602042e-05 NA NA NA hsa-miR-30e-5p CPD -0.627815042856657 3.02205690184908e-10 0.599470550586786 4.65999718552314e-06 mirMAP -0.1997662042067 0.00173505986601705 NA NA NA hsa-miR-15a-5p CPEB2 0.349521211668244 0.000770735998804736 -0.777113534729999 2.2574055916853e-08 miRNATAP -0.203773238306035 0.00216274361921829 NA NA NA hsa-miR-15a-5p CPEB3 0.349521211668244 0.000770735998804736 -2.73760799365771 6.08365930201296e-43 MirTarget;miRNATAP -0.437993335622186 2.45601504208893e-05 NA NA NA hsa-miR-17-3p CPEB3 0.410352776142368 0.00422200500748636 -2.73760799365771 6.08365930201296e-43 MirTarget;miRNATAP -0.359243578664339 1.50350318283461e-06 NA NA NA hsa-miR-19b-3p CPEB3 0.601279551368824 0.00016685097085251 -2.73760799365771 6.08365930201296e-43 MirTarget -0.389976771323369 4.00425592108106e-09 NA NA NA hsa-miR-20a-5p CPEB3 0.854326758727003 5.04256669663285e-07 -2.73760799365771 6.08365930201296e-43 miRNATAP -0.445462831110694 3.20580969307668e-13 NA NA NA hsa-miR-20b-5p CPEB3 0.457668023910379 0.0285865211936156 -2.73760799365771 6.08365930201296e-43 miRNATAP -0.222464217887538 1.43877614716701e-05 NA NA NA hsa-miR-21-5p CPEB3 1.51084295924322 1.54551622173259e-34 -2.73760799365771 6.08365930201296e-43 miRNAWalker2_validate;MirTarget;miRNATAP -0.980746493840046 7.30211745183844e-41 NA NA NA hsa-miR-224-3p CPEB3 1.40770116795301 1.31426607144612e-08 -2.73760799365771 6.08365930201296e-43 mirMAP -0.145163272039773 0.000805278481730715 NA NA NA hsa-miR-34a-5p CPEB3 1.03694231790865 5.74864019540594e-14 -2.73760799365771 6.08365930201296e-43 miRNATAP -0.197453478951789 0.00956041493718287 NA NA NA hsa-miR-132-3p CPEB4 0.323796239695997 0.00272093067935091 -1.06097838176943 9.01316045116939e-14 miRNATAP -0.28242339052308 1.92508586470439e-05 NA NA NA hsa-miR-181a-5p CPEB4 0.250113435902954 0.0551933249319293 -1.06097838176943 9.01316045116939e-14 miRNATAP -0.289302303462762 1.03157414337608e-07 NA NA NA hsa-miR-181b-5p CPEB4 0.488256489401108 0.00105321129419701 -1.06097838176943 9.01316045116939e-14 miRNATAP -0.293627483456073 4.15505130809149e-10 NA NA NA hsa-miR-19b-3p CPEB4 0.601279551368824 0.00016685097085251 -1.06097838176943 9.01316045116939e-14 mirMAP;miRNATAP -0.198815822829552 6.92040914397599e-06 NA NA NA hsa-miR-20a-5p CPEB4 0.854326758727003 5.04256669663285e-07 -1.06097838176943 9.01316045116939e-14 mirMAP -0.221772086536128 6.43257989653563e-08 NA NA NA hsa-miR-20b-5p CPEB4 0.457668023910379 0.0285865211936156 -1.06097838176943 9.01316045116939e-14 mirMAP -0.14033394853334 3.59115458126349e-05 NA NA NA hsa-miR-30c-5p CPLX1 -0.432111642767632 0.000159764714931007 0.817008398608116 0.00266488469970708 mirMAP -0.485472473656033 2.68741472730432e-05 NA NA NA hsa-miR-30e-5p CPLX1 -0.627815042856657 3.02205690184908e-10 0.817008398608116 0.00266488469970708 mirMAP -0.415663734237142 0.00160943246779734 NA NA NA hsa-miR-214-5p CPLX2 -1.91497809567701 3.92955595018147e-12 5.16430096205473 2.83212867957316e-12 mirMAP;miRNATAP -0.645939044777816 8.36344807674174e-07 NA NA NA hsa-miR-27b-3p CPLX2 -0.823491817819754 9.20935302746823e-14 5.16430096205473 2.83212867957316e-12 mirMAP -2.34864563500762 1.65938410416298e-13 NA NA NA hsa-miR-17-3p CPNE8 0.410352776142368 0.00422200500748636 -0.764323108203908 3.17718650291404e-08 MirTarget -0.182470050246214 0.000121896405394482 NA NA NA hsa-miR-221-3p CPNE8 1.12244756358612 3.48370308238012e-13 -0.764323108203908 3.17718650291404e-08 MirTarget;miRNATAP -0.299051871575289 1.13961265873534e-12 NA NA NA hsa-miR-222-3p CPNE8 1.08574156066353 1.76407192348131e-11 -0.764323108203908 3.17718650291404e-08 MirTarget;miRNATAP -0.224287973552576 3.95842059106719e-08 NA NA NA hsa-miR-181a-5p CPOX 0.250113435902954 0.0551933249319293 -0.645483352349819 2.25342441240631e-12 MirTarget -0.156533147062433 8.18923724766753e-06 NA NA NA hsa-miR-181b-5p CPOX 0.488256489401108 0.00105321129419701 -0.645483352349819 2.25342441240631e-12 MirTarget -0.16613920486179 4.38128953909762e-08 NA NA NA hsa-miR-19b-3p CPPED1 0.601279551368824 0.00016685097085251 0.161877607319542 0.18491305944346 miRNAWalker2_validate -0.117335324774701 0.00149279932061543 NA NA NA hsa-miR-30b-5p CPSF2 -0.54056186708617 2.44688760798341e-05 0.00900725462432561 0.883837193964709 mirMAP -0.102923798449425 7.2379641581675e-06 NA NA NA hsa-miR-30e-5p CPSF6 -0.627815042856657 3.02205690184908e-10 0.528850368138479 7.89466331012242e-16 MirTarget -0.112655028338967 0.000545279326550635 NA NA NA hsa-miR-224-3p CR1 1.40770116795301 1.31426607144612e-08 -2.56605616284755 6.18825669692394e-18 mirMAP -0.299325303160799 6.42539659140613e-07 NA NA NA hsa-miR-34a-5p CR2 1.03694231790865 5.74864019540594e-14 -0.586208934608462 0.11485583970786 MirTarget -0.327210640432696 0.0104616524803239 NA NA NA hsa-miR-146b-5p CRB3 0.419719546795449 0.0457375823220155 -0.0660505356732926 0.720719076998658 PITA;miRanda -0.13774221386858 0.00124675366768684 NA NA NA hsa-miR-20a-5p CREB5 0.854326758727003 5.04256669663285e-07 0.00174118159445535 0.993131455555257 MirTarget;miRNATAP -0.146915422744345 0.0102509871192745 NA NA NA hsa-miR-15a-5p CREBL2 0.349521211668244 0.000770735998804736 -0.86271516459951 5.41073501751202e-18 miRNAWalker2_validate -0.188930204189878 0.00010444069549546 NA NA NA hsa-miR-181a-5p CREBL2 0.250113435902954 0.0551933249319293 -0.86271516459951 5.41073501751202e-18 MirTarget -0.256855421490494 1.56102997939327e-11 NA NA NA hsa-miR-181b-5p CREBL2 0.488256489401108 0.00105321129419701 -0.86271516459951 5.41073501751202e-18 MirTarget -0.275659614826832 3.03458501290093e-17 NA NA NA hsa-miR-19b-3p CREBL2 0.601279551368824 0.00016685097085251 -0.86271516459951 5.41073501751202e-18 miRNAWalker2_validate;miRNATAP -0.229027341347348 7.85586558111367e-14 NA NA NA hsa-miR-21-5p CREBL2 1.51084295924322 1.54551622173259e-34 -0.86271516459951 5.41073501751202e-18 miRNATAP -0.279086534335069 3.23834303999446e-14 NA NA NA hsa-miR-221-3p CREBL2 1.12244756358612 3.48370308238012e-13 -0.86271516459951 5.41073501751202e-18 MirTarget -0.263088230630059 1.03665184994387e-17 NA NA NA hsa-miR-222-3p CREBL2 1.08574156066353 1.76407192348131e-11 -0.86271516459951 5.41073501751202e-18 MirTarget -0.261419620252231 5.34336889122515e-19 NA NA NA hsa-miR-503-5p CREBL2 0.191949282338049 0.268420664548092 -0.86271516459951 5.41073501751202e-18 MirTarget -0.102942801204191 0.000414994550947535 NA NA NA hsa-miR-15a-5p CRIM1 0.349521211668244 0.000770735998804736 -0.427323666964741 0.0396278582056627 MirTarget;miRNATAP -0.344528467851632 0.000416599296704137 NA NA NA hsa-miR-20a-5p CRIM1 0.854326758727003 5.04256669663285e-07 -0.427323666964741 0.0396278582056627 miRTarBase;MirTarget;miRNATAP -0.44427476286557 6.87894558189768e-15 NA NA NA hsa-miR-21-5p CRIM1 1.51084295924322 1.54551622173259e-34 -0.427323666964741 0.0396278582056627 miRNATAP -0.151258114496889 0.0465522385435014 NA NA NA hsa-miR-20a-5p CRK 0.854326758727003 5.04256669663285e-07 -0.66019370420832 1.97619097308481e-10 MirTarget;miRNATAP -0.120757871328387 5.13100158700272e-05 NA NA NA hsa-miR-20b-5p CRK 0.457668023910379 0.0285865211936156 -0.66019370420832 1.97619097308481e-10 MirTarget;miRNATAP -0.104407248587283 2.00406443364122e-05 NA NA NA hsa-miR-505-5p CRMP1 -0.768282569967001 1.14662846595407e-05 1.02616128117857 2.20763467869246e-05 MirTarget -0.305550849098525 4.82579869574085e-06 NA NA NA hsa-miR-20a-5p CRYBG3 0.854326758727003 5.04256669663285e-07 -0.701440679666375 0.0115118986767452 MirTarget;miRNATAP -0.482353837183608 4.55438910089713e-10 NA NA NA hsa-miR-148a-3p CS -0.748702855596996 3.93313343865641e-07 0.630496195920363 1.14583127791941e-12 miRNATAP -0.1545115311895 1.37525350059388e-07 NA NA NA hsa-miR-148a-3p CSF1 -0.748702855596996 3.93313343865641e-07 -0.5853277886696 0.00153229238014141 miRNATAP -0.256768312227477 2.00461329540934e-05 NA NA NA hsa-miR-20a-5p CSF1 0.854326758727003 5.04256669663285e-07 -0.5853277886696 0.00153229238014141 miRNATAP -0.281846084837308 5.48117776284526e-08 NA NA NA hsa-miR-455-3p CSF1 -1.3998033821095 5.72010709806871e-17 -0.5853277886696 0.00153229238014141 mirMAP -0.11714078431287 0.0246073498421681 NA NA NA hsa-miR-34a-5p CSF1R 1.03694231790865 5.74864019540594e-14 -1.22973996011932 1.03080978200997e-10 MirTarget;miRNATAP -0.170397067894218 0.0108753863449133 NA NA NA hsa-miR-19b-3p CSF2RB 0.601279551368824 0.00016685097085251 -0.510057706101157 0.00683192745956236 MirTarget -0.154504842048333 0.0071335754861484 NA NA NA hsa-miR-455-5p CSF2RB -0.270546034117157 0.0581320703577731 -0.510057706101157 0.00683192745956236 miRanda -0.37382538214599 4.3712193850043e-09 NA NA NA hsa-miR-20a-5p CSGALNACT1 0.854326758727003 5.04256669663285e-07 0.194748522387815 0.229122552908902 MirTarget -0.208588980914546 4.42121116516048e-06 NA NA NA hsa-miR-409-3p CSMD1 -0.499649792570937 0.0526751181520117 3.23745692089652 4.45194111243163e-09 mirMAP -0.287094230372258 0.00685288221510104 NA NA NA hsa-miR-19b-3p CSNK1A1 0.601279551368824 0.00016685097085251 -0.337358696279789 1.0388780822195e-09 mirMAP -0.102374765378003 7.70223411359268e-10 NA NA NA hsa-miR-21-5p CSNK1A1 1.51084295924322 1.54551622173259e-34 -0.337358696279789 1.0388780822195e-09 miRNAWalker2_validate -0.104077813571288 2.3200921239842e-07 NA NA NA hsa-miR-29c-3p CSNK1D -1.4367517608807 1.61767774905781e-21 0.4731959867792 3.43904217952384e-13 mirMAP -0.153963096922558 8.21998200113075e-15 NA NA NA hsa-miR-30b-5p CSNK1G1 -0.54056186708617 2.44688760798341e-05 0.5242161160821 3.26619328715997e-11 MirTarget;mirMAP -0.115443491202922 0.000147011549397768 NA NA NA hsa-miR-181a-5p CSNK1G3 0.250113435902954 0.0551933249319293 -0.368768249275336 6.89562099916135e-07 mirMAP;miRNATAP -0.119212755516649 1.92467720367577e-05 NA NA NA hsa-miR-181b-5p CSNK1G3 0.488256489401108 0.00105321129419701 -0.368768249275336 6.89562099916135e-07 mirMAP;miRNATAP -0.116637274657514 1.4293217699323e-06 NA NA NA hsa-miR-30c-5p CSNK2A2 -0.432111642767632 0.000159764714931007 0.0716365631905207 0.389146554448819 mirMAP -0.107697084400435 0.00221143602273193 NA NA NA hsa-miR-148a-3p CSPG4 -0.748702855596996 3.93313343865641e-07 2.20938998217354 1.93186590158878e-35 miRNATAP -0.47109794771531 1.88996499141413e-14 NA NA NA hsa-miR-505-5p CSPP1 -0.768282569967001 1.14662846595407e-05 0.598987869305078 6.80759567326541e-06 miRNAWalker2_validate -0.123351289750119 0.000854730171929692 NA NA NA hsa-miR-15a-5p CSRNP1 0.349521211668244 0.000770735998804736 -2.34479696949524 3.99644267118318e-52 MirTarget -0.22686905358562 0.00611415400298197 NA NA NA hsa-miR-146b-5p CTBP2 0.419719546795449 0.0457375823220155 -0.39317918949034 0.0225071278697855 miRanda -0.176036756804994 9.21105923068651e-06 NA NA NA hsa-miR-194-5p CTDSPL -0.292530160992458 0.0996141384876663 0.0757033671137659 0.487293695066413 mirMAP -0.107773523765341 0.000288194172310088 NA NA NA hsa-miR-99a-5p CTDSPL -1.51481656384839 3.93230057259529e-14 0.0757033671137659 0.487293695066413 MirTarget;miRNATAP -0.14471219102009 9.4201281463867e-09 NA NA NA hsa-miR-29c-3p CTDSPL2 -1.4367517608807 1.61767774905781e-21 -0.0476560238772321 0.630877276868522 MirTarget -0.124008277466869 4.05603608439671e-05 NA NA NA hsa-miR-30c-5p CTHRC1 -0.432111642767632 0.000159764714931007 3.17822009022244 8.77701727783127e-20 MirTarget -0.434766973376751 0.00530609194063901 NA NA NA hsa-miR-30e-5p CTHRC1 -0.627815042856657 3.02205690184908e-10 3.17822009022244 8.77701727783127e-20 MirTarget -1.26947796546048 1.62346037971745e-13 NA NA NA hsa-miR-146b-5p CTNNA3 0.419719546795449 0.0457375823220155 -2.93718508917758 1.13925248568176e-18 miRanda -0.226544923718825 0.00498984553126637 NA NA NA hsa-miR-34a-5p CTNND2 1.03694231790865 5.74864019540594e-14 -1.18454154034261 0.0540804866207506 MirTarget -1.44873269316095 2.17523705117805e-12 NA NA NA hsa-miR-19b-3p CTSB 0.601279551368824 0.00016685097085251 -0.936613099353503 3.42235462744283e-13 mirMAP -0.132183947976646 0.000990319328795726 NA NA NA hsa-miR-148a-3p CTTNBP2NL -0.748702855596996 3.93313343865641e-07 0.0265420118187079 0.819395334474897 MirTarget;miRNATAP -0.400219991755329 7.16863410683787e-30 NA NA NA hsa-miR-194-5p CTTNBP2NL -0.292530160992458 0.0996141384876663 0.0265420118187079 0.819395334474897 MirTarget -0.331089026144075 8.00751560915828e-29 NA NA NA hsa-miR-30b-5p CUL2 -0.54056186708617 2.44688760798341e-05 0.221493309659475 0.000775493336759859 MirTarget;mirMAP;miRNATAP -0.104130690012811 2.59410967342164e-05 NA NA NA hsa-miR-27b-3p CUL4B -0.823491817819754 9.20935302746823e-14 0.321392957566996 8.06539050055239e-06 miRNAWalker2_validate -0.106007625746476 0.000643446334148388 NA NA NA hsa-miR-30b-5p CUL4B -0.54056186708617 2.44688760798341e-05 0.321392957566996 8.06539050055239e-06 mirMAP -0.105921248697871 0.000102849585059723 NA NA NA hsa-miR-30c-5p CUX1 -0.432111642767632 0.000159764714931007 -0.187927348104609 0.0398134377996123 mirMAP -0.108913424995932 0.00503079989547292 NA NA NA hsa-miR-181a-5p CXADR 0.250113435902954 0.0551933249319293 -0.234780594951993 0.196678109410481 miRNATAP -0.244137876341052 0.000327208843969134 NA NA NA hsa-miR-181b-5p CXADR 0.488256489401108 0.00105321129419701 -0.234780594951993 0.196678109410481 miRNATAP -0.173380879235352 0.00343841362321261 NA NA NA hsa-miR-455-5p CXCL11 -0.270546034117157 0.0581320703577731 0.567735170963921 0.0675290779314295 miRanda -0.290544481387034 0.00632480853617806 NA NA NA hsa-miR-221-3p CXCL12 1.12244756358612 3.48370308238012e-13 -3.59146357807385 1.03718574480494e-35 MirTarget -0.313249809796118 0.00117662736734837 NA NA NA hsa-miR-222-3p CXCL12 1.08574156066353 1.76407192348131e-11 -3.59146357807385 1.03718574480494e-35 MirTarget -0.247137611961592 0.00776299898035471 NA NA NA hsa-miR-20a-5p CXCL6 0.854326758727003 5.04256669663285e-07 -3.43495201431017 2.61831723964962e-09 MirTarget -0.840433867564058 3.46698534970176e-07 NA NA NA hsa-miR-20a-5p CXorf23 0.854326758727003 5.04256669663285e-07 0.430761186308626 9.49129189428509e-06 mirMAP -0.10083578676636 0.000265555846338066 NA NA NA hsa-miR-455-3p CXorf36 -1.3998033821095 5.72010709806871e-17 2.29398728639761 1.97899103408404e-58 mirMAP -0.310600346171132 5.59808512377137e-12 NA NA NA hsa-miR-20a-5p CXorf38 0.854326758727003 5.04256669663285e-07 -0.20690073441604 0.0251657719260332 mirMAP -0.127422909367595 8.33539229786413e-07 NA NA NA hsa-miR-192-5p CYB561D1 -0.50188499512787 0.00344713341196035 1.35618855619484 4.53684308721849e-24 mirMAP -0.202495820420795 3.58922576334244e-07 NA NA NA hsa-miR-194-5p CYB561D1 -0.292530160992458 0.0996141384876663 1.35618855619484 4.53684308721849e-24 mirMAP -0.183032708879684 2.16301771865049e-06 NA NA NA hsa-miR-29c-3p CYB561D1 -1.4367517608807 1.61767774905781e-21 1.35618855619484 4.53684308721849e-24 mirMAP -0.303422804873668 1.01156941366739e-12 NA NA NA hsa-miR-30e-5p CYB561D1 -0.627815042856657 3.02205690184908e-10 1.35618855619484 4.53684308721849e-24 mirMAP -0.290587994570127 2.00688867133405e-05 NA NA NA hsa-miR-505-5p CYB561D1 -0.768282569967001 1.14662846595407e-05 1.35618855619484 4.53684308721849e-24 MirTarget -0.16622845367457 1.93763748604883e-05 NA NA NA hsa-miR-30b-5p CYB5B -0.54056186708617 2.44688760798341e-05 0.0140340773849958 0.888360430421686 miRNAWalker2_validate;mirMAP -0.102540111047914 0.00655640850302147 NA NA NA hsa-miR-146b-5p CYB5D1 0.419719546795449 0.0457375823220155 -0.738980430951122 5.158587364402e-14 mirMAP -0.101695726905217 1.23178456683939e-05 NA NA NA hsa-miR-192-5p CYBRD1 -0.50188499512787 0.00344713341196035 -1.29333537908526 9.44725361000613e-10 mirMAP -0.300732503720988 6.7769310823661e-07 NA NA NA hsa-miR-20a-5p CYBRD1 0.854326758727003 5.04256669663285e-07 -1.29333537908526 9.44725361000613e-10 MirTarget -0.366559433107161 1.03284392805768e-09 NA NA NA hsa-miR-21-5p CYBRD1 1.51084295924322 1.54551622173259e-34 -1.29333537908526 9.44725361000613e-10 miRNAWalker2_validate -0.314388439169356 5.96588466109424e-05 NA NA NA hsa-miR-224-3p CYBRD1 1.40770116795301 1.31426607144612e-08 -1.29333537908526 9.44725361000613e-10 mirMAP -0.122421761260854 0.0037368845933181 NA NA NA hsa-miR-19b-3p CYLD 0.601279551368824 0.00016685097085251 -0.423088167274311 1.00113522728174e-06 miRNATAP -0.165838281816206 1.72495010949886e-10 NA NA NA hsa-miR-30b-5p CYLD -0.54056186708617 2.44688760798341e-05 -0.423088167274311 1.00113522728174e-06 mirMAP -0.110632068010283 0.000797142509893685 NA NA NA hsa-miR-30e-5p CYP19A1 -0.627815042856657 3.02205690184908e-10 1.83361302420833 2.08463700012796e-05 mirMAP -0.643508452409046 0.0021851268708534 NA NA NA hsa-miR-146b-5p CYP1B1 0.419719546795449 0.0457375823220155 -0.0782876655143347 0.760967318096207 miRanda -0.12194005018059 0.0410629412351803 NA NA NA hsa-miR-221-3p CYP1B1 1.12244756358612 3.48370308238012e-13 -0.0782876655143347 0.760967318096207 miRNAWalker2_validate;MirTarget -0.243561056612926 0.002022863297573 NA NA NA hsa-miR-222-3p CYP1B1 1.08574156066353 1.76407192348131e-11 -0.0782876655143347 0.760967318096207 MirTarget -0.202706409791028 0.00750386401803817 NA NA NA hsa-miR-132-3p CYP26A1 0.323796239695997 0.00272093067935091 -5.43003774879853 9.27168290711595e-33 miRNAWalker2_validate -0.45989839645696 0.0405233102511065 NA NA NA hsa-miR-192-3p CYP26B1 -0.6401165114007 0.000266272092403814 -0.867744723637369 0.0171433375851216 MirTarget -0.40232224018924 6.0082331894744e-05 NA NA NA hsa-miR-194-5p CYP26B1 -0.292530160992458 0.0996141384876663 -0.867744723637369 0.0171433375851216 mirMAP -0.571803227084593 6.85196227784281e-09 NA NA NA hsa-miR-99a-5p CYP26B1 -1.51481656384839 3.93230057259529e-14 -0.867744723637369 0.0171433375851216 miRNATAP -0.255217475151687 0.00297801954435737 NA NA NA hsa-miR-132-3p CYP2E1 0.323796239695997 0.00272093067935091 -4.32881841635836 5.53063911805581e-12 miRNAWalker2_validate -0.969046572691262 0.000906394643072438 NA NA NA hsa-miR-19b-3p CYP2U1 0.601279551368824 0.00016685097085251 -1.01838808023932 3.26776270502471e-10 miRNAWalker2_validate;MirTarget -0.298206686512773 1.58404033730678e-09 NA NA NA hsa-miR-20a-5p CYP2U1 0.854326758727003 5.04256669663285e-07 -1.01838808023932 3.26776270502471e-10 MirTarget -0.331028787727269 4.09019841310736e-13 NA NA NA hsa-miR-30b-5p CYP2U1 -0.54056186708617 2.44688760798341e-05 -1.01838808023932 3.26776270502471e-10 mirMAP -0.178134311477301 0.00449652585336022 NA NA NA hsa-miR-181a-5p CYP4F3 0.250113435902954 0.0551933249319293 -1.55307662086169 1.07679103282901e-07 mirMAP -0.769185103989242 1.42446818442085e-12 NA NA NA hsa-miR-181b-5p CYP4F3 0.488256489401108 0.00105321129419701 -1.55307662086169 1.07679103282901e-07 mirMAP -0.808038178475637 3.98523550732589e-18 NA NA NA hsa-miR-21-5p CYP4V2 1.51084295924322 1.54551622173259e-34 -1.71426542413107 2.57937029230203e-24 miRNAWalker2_validate -0.70899133339694 8.38005084001024e-32 NA NA NA hsa-miR-15a-5p CYS1 0.349521211668244 0.000770735998804736 -3.27202242326171 1.69945462804925e-16 mirMAP -0.906122224357138 2.5901975547775e-06 NA NA NA hsa-miR-148a-3p CYTH3 -0.748702855596996 3.93313343865641e-07 0.609753795487233 1.49167558303658e-06 MirTarget;miRNATAP -0.287885455378431 1.71620007242084e-12 NA NA NA hsa-miR-17-3p CYTH3 0.410352776142368 0.00422200500748636 0.609753795487233 1.49167558303658e-06 MirTarget -0.22005525163094 3.188206460795e-07 NA NA NA hsa-miR-194-5p CYTH3 -0.292530160992458 0.0996141384876663 0.609753795487233 1.49167558303658e-06 mirMAP -0.284668686786984 4.4727424110496e-17 NA NA NA hsa-miR-455-5p CYTH4 -0.270546034117157 0.0581320703577731 -0.0320490491804084 0.851298391951766 miRanda -0.24229612016498 3.008122958015e-05 NA NA NA hsa-miR-181a-5p DAAM1 0.250113435902954 0.0551933249319293 -0.820319075229238 3.16122030911227e-05 mirMAP -0.206291476669735 0.00568464658531029 NA NA NA hsa-miR-181b-5p DAAM1 0.488256489401108 0.00105321129419701 -0.820319075229238 3.16122030911227e-05 mirMAP -0.244543574167562 0.000154525603721181 NA NA NA hsa-miR-19b-3p DAAM1 0.601279551368824 0.00016685097085251 -0.820319075229238 3.16122030911227e-05 miRNATAP -0.251357652633507 2.81850564678398e-05 NA NA NA hsa-miR-21-5p DAAM1 1.51084295924322 1.54551622173259e-34 -0.820319075229238 3.16122030911227e-05 miRNAWalker2_validate -0.578036099340168 1.45141919650478e-16 NA NA NA hsa-miR-146b-5p DAAM2 0.419719546795449 0.0457375823220155 -0.827336419502445 6.34713523969009e-05 miRanda -0.119810383092939 0.0132408049997276 NA NA NA hsa-miR-182-5p DAAM2 1.96601340710222 4.39326175603633e-09 -0.827336419502445 6.34713523969009e-05 mirMAP -0.151231784560416 2.6298365470906e-07 NA NA NA hsa-miR-19b-3p DAAM2 0.601279551368824 0.00016685097085251 -0.827336419502445 6.34713523969009e-05 miRNAWalker2_validate -0.245450167728416 9.86406700949337e-05 NA NA NA hsa-miR-20a-5p DAB2 0.854326758727003 5.04256669663285e-07 -0.0812678108323723 0.659390389044208 MirTarget;miRNATAP -0.149841610964144 0.00403571251642021 NA NA NA hsa-miR-505-5p DAB2IP -0.768282569967001 1.14662846595407e-05 0.538900746345808 3.78367252969261e-05 mirMAP -0.116126828502663 0.00137520446744831 NA NA NA hsa-miR-30c-5p DAGLA -0.432111642767632 0.000159764714931007 1.16197262256378 7.56867119602314e-06 miRNATAP -0.276304160986499 0.0134835971334183 NA NA NA hsa-miR-455-5p DAPP1 -0.270546034117157 0.0581320703577731 -0.890941342221901 5.86894518840803e-05 miRanda -0.266614869424436 0.000476322736327222 NA NA NA hsa-miR-20a-5p DAZAP2 0.854326758727003 5.04256669663285e-07 -0.394188137321676 2.84409057316998e-10 MirTarget;miRNATAP -0.11332417819355 1.16334033949638e-10 NA NA NA hsa-miR-30b-5p DBF4 -0.54056186708617 2.44688760798341e-05 0.924895042673626 1.9008434964275e-15 MirTarget -0.115375084345556 0.011497459671902 NA NA NA hsa-miR-30e-5p DBF4 -0.627815042856657 3.02205690184908e-10 0.924895042673626 1.9008434964275e-15 MirTarget -0.167793410853246 0.00390640864782242 NA NA NA hsa-miR-215-5p DBF4B -0.981544773246509 3.14452272477156e-05 1.55009756540313 1.30826586160845e-27 miRNAWalker2_validate -0.13384641275561 1.53102636548703e-05 NA NA NA hsa-miR-27b-3p DBF4B -0.823491817819754 9.20935302746823e-14 1.55009756540313 1.30826586160845e-27 MirTarget -0.278647490530304 1.88561296441866e-05 NA NA NA hsa-miR-505-5p DBN1 -0.768282569967001 1.14662846595407e-05 1.22908274202267 1.07132266803334e-08 miRNATAP -0.342929821925476 8.01502676565265e-09 NA NA NA hsa-miR-30c-5p DBNL -0.432111642767632 0.000159764714931007 0.31972388863359 3.12541022895006e-05 mirMAP -0.136028113394491 3.0466878432027e-05 NA NA NA hsa-miR-30e-5p DBNL -0.627815042856657 3.02205690184908e-10 0.31972388863359 3.12541022895006e-05 mirMAP -0.246126552730558 1.34684401251158e-11 NA NA NA hsa-miR-21-5p DCAF10 1.51084295924322 1.54551622173259e-34 -0.27023416404054 0.000162269494983322 miRNAWalker2_validate -0.1886444046417 1.1767746170605e-13 NA NA NA hsa-miR-455-5p DCAF4L1 -0.270546034117157 0.0581320703577731 1.82732435390596 2.33240027694037e-14 miRanda -0.169765470423439 0.0455637417356508 NA NA NA hsa-miR-29c-3p DCAF7 -1.4367517608807 1.61767774905781e-21 0.251218863383806 0.00107426725385292 MirTarget;miRNATAP -0.144889336158128 4.10061589341847e-10 NA NA NA hsa-miR-30b-5p DCAF7 -0.54056186708617 2.44688760798341e-05 0.251218863383806 0.00107426725385292 mirMAP -0.137439988543511 1.86455484041883e-06 NA NA NA hsa-miR-132-3p DCAF8 0.323796239695997 0.00272093067935091 -0.0265942497922618 0.751662897530488 miRNATAP -0.288803917476954 3.38931793850498e-15 NA NA NA hsa-miR-21-5p DCAF8 1.51084295924322 1.54551622173259e-34 -0.0265942497922618 0.751662897530488 miRNAWalker2_validate -0.162351371603683 6.7996925496588e-08 NA NA NA hsa-miR-15a-5p DCLK1 0.349521211668244 0.000770735998804736 0.506332104006503 0.0548943698262157 miRNATAP -0.381597652739602 0.00212307328812188 NA NA NA hsa-miR-17-3p DCLK1 0.410352776142368 0.00422200500748636 0.506332104006503 0.0548943698262157 MirTarget;miRNATAP -0.199261138753086 0.0265945046843562 NA NA NA hsa-miR-146b-5p DCLK2 0.419719546795449 0.0457375823220155 0.179869431235858 0.29607841437226 miRanda -0.139463998747644 0.000447505223039629 NA NA NA hsa-miR-146b-5p DCN 0.419719546795449 0.0457375823220155 -4.16086251487049 1.15620570061837e-21 miRanda -0.226596464669267 0.0333660092962088 NA NA NA hsa-miR-29c-3p DCP2 -1.4367517608807 1.61767774905781e-21 0.261080000757517 0.00123409478740543 MirTarget -0.186574055200945 9.789541214902e-15 NA NA NA hsa-miR-15a-5p DCUN1D1 0.349521211668244 0.000770735998804736 -0.454096561519516 2.98980089676835e-05 MirTarget -0.233138584543926 5.20257885751273e-06 NA NA NA hsa-miR-181a-5p DCUN1D1 0.250113435902954 0.0551933249319293 -0.454096561519516 2.98980089676835e-05 MirTarget;mirMAP -0.110944209189268 0.00693360963312391 NA NA NA hsa-miR-221-3p DCUN1D1 1.12244756358612 3.48370308238012e-13 -0.454096561519516 2.98980089676835e-05 MirTarget -0.182188557878299 4.09071502586311e-08 NA NA NA hsa-miR-222-3p DCUN1D1 1.08574156066353 1.76407192348131e-11 -0.454096561519516 2.98980089676835e-05 MirTarget -0.142351109825055 8.97752555169531e-06 NA NA NA hsa-miR-132-3p DCUN1D3 0.323796239695997 0.00272093067935091 -1.24556558748867 1.01261431238042e-35 MirTarget -0.162987093243277 0.000931964196997364 NA NA NA hsa-miR-20a-5p DCUN1D3 0.854326758727003 5.04256669663285e-07 -1.24556558748867 1.01261431238042e-35 MirTarget -0.160550668144602 1.34972646858528e-07 NA NA NA hsa-miR-221-3p DCUN1D4 1.12244756358612 3.48370308238012e-13 -0.241051443609763 0.00351891274628995 MirTarget -0.100305199054875 7.0338674223595e-05 NA NA NA hsa-miR-222-3p DCUN1D4 1.08574156066353 1.76407192348131e-11 -0.241051443609763 0.00351891274628995 MirTarget -0.122160077700631 3.86583225895706e-07 NA NA NA hsa-miR-30e-5p DCX -0.627815042856657 3.02205690184908e-10 1.11436535387574 0.000685870057148693 mirMAP -0.402520370229269 0.0116871453816594 NA NA NA hsa-miR-455-3p DCX -1.3998033821095 5.72010709806871e-17 1.11436535387574 0.000685870057148693 miRNATAP -0.23931212105487 0.00980677129740882 NA NA NA hsa-miR-21-5p DDAH1 1.51084295924322 1.54551622173259e-34 -0.918386843412848 3.01044229943748e-09 miRNAWalker2_validate -0.392903247297597 2.61310628460181e-12 26741162 In vitro study showed QTsome/AM-21 induced upregulation of miR-21 targets including PTEN and DDAH1 in A549 cells while increasing their sensitivity toward paclitaxel PTX lung cancer hsa-miR-221-3p DDAH1 1.12244756358612 3.48370308238012e-13 -0.918386843412848 3.01044229943748e-09 miRNAWalker2_validate -0.231632930713386 1.41877548281945e-06 NA NA NA hsa-miR-192-5p DDHD1 -0.50188499512787 0.00344713341196035 0.275816408841005 0.021963997897021 miRNAWalker2_validate -0.127991076982228 0.00016546494069896 NA NA NA hsa-miR-19b-3p DDI2 0.601279551368824 0.00016685097085251 -1.53096229477393 2.81259482387215e-06 mirMAP -0.266248480558007 0.00805977027382086 NA NA NA hsa-miR-409-3p DDI2 -0.499649792570937 0.0526751181520117 -1.53096229477393 2.81259482387215e-06 mirMAP -0.137250955328459 0.0280976098776364 NA NA NA hsa-miR-432-5p DDI2 -0.536178819038888 0.0748623258271085 -1.53096229477393 2.81259482387215e-06 MirTarget -0.13590653372943 0.0113831134602357 NA NA NA hsa-miR-146b-5p DDIT4L 0.419719546795449 0.0457375823220155 0.436551660589106 0.0942038404706412 miRanda -0.166034247067451 0.00604382604189294 NA NA NA hsa-miR-34a-5p DDR1 1.03694231790865 5.74864019540594e-14 0.19463335306942 0.483361341487924 mirMAP -0.336092527775466 0.000402664286007172 NA NA NA hsa-miR-21-5p DDR2 1.51084295924322 1.54551622173259e-34 -0.840962754160993 0.00127709673572228 miRNAWalker2_validate -0.303610798872828 0.00148820739751815 NA NA NA hsa-miR-192-3p DDX11 -0.6401165114007 0.000266272092403814 1.44752503641813 4.09048996563645e-17 mirMAP -0.201912281427773 4.04417295981153e-05 NA NA NA hsa-miR-34a-5p DDX21 1.03694231790865 5.74864019540594e-14 -0.639054499739112 0.000259980915278802 miRNAWalker2_validate -0.145694757197931 0.0160530352092621 NA NA NA hsa-miR-15a-5p DDX3X 0.349521211668244 0.000770735998804736 -0.695107825481528 1.74554774697009e-17 miRNATAP -0.144684435352344 0.00027527028173289 NA NA NA hsa-miR-21-5p DDX3X 1.51084295924322 1.54551622173259e-34 -0.695107825481528 1.74554774697009e-17 miRNAWalker2_validate -0.201463309127107 2.71491429159216e-11 NA NA NA hsa-miR-221-3p DDX3X 1.12244756358612 3.48370308238012e-13 -0.695107825481528 1.74554774697009e-17 miRNATAP -0.100622298174859 0.000104064592416466 NA NA NA hsa-miR-29c-3p DDX46 -1.4367517608807 1.61767774905781e-21 0.245459109531455 0.000284588648765968 MirTarget -0.123984819219942 1.29337496099407e-09 NA NA NA hsa-miR-17-3p DDX5 0.410352776142368 0.00422200500748636 -0.0924295851697927 0.146621310444743 MirTarget -0.104837635754241 7.95012724208848e-07 NA NA NA hsa-miR-181a-5p DDX60L 0.250113435902954 0.0551933249319293 -0.811104267116272 3.25564263019604e-07 MirTarget -0.144548656230519 0.0167821603643121 NA NA NA hsa-miR-181b-5p DDX60L 0.488256489401108 0.00105321129419701 -0.811104267116272 3.25564263019604e-07 MirTarget -0.169427467105289 0.00123147545717295 NA NA NA hsa-miR-192-5p DEAF1 -0.50188499512787 0.00344713341196035 0.730388231552352 6.33628408362944e-15 miRNAWalker2_validate -0.116881065661527 1.74444308703138e-05 NA NA NA hsa-miR-17-3p DEFB132 0.410352776142368 0.00422200500748636 0.751047410323858 0.0935342175873046 miRNATAP -0.539390893669778 0.000382237908470286 NA NA NA hsa-miR-192-5p DEGS1 -0.50188499512787 0.00344713341196035 0.402759746150533 4.33549672472546e-05 miRNAWalker2_validate -0.130817180464935 2.58661311896181e-06 NA NA NA hsa-miR-30b-5p DENND1B -0.54056186708617 2.44688760798341e-05 0.184119225845451 0.312131121857309 mirMAP -0.159118437193553 0.021171543491485 NA NA NA hsa-miR-15a-5p DENND4A 0.349521211668244 0.000770735998804736 -0.853867719776376 8.19443473956909e-12 MirTarget -0.226396123373907 0.000163780403073732 NA NA NA hsa-miR-181a-5p DENND4C 0.250113435902954 0.0551933249319293 -0.449333876796266 4.55066587024558e-06 MirTarget -0.101383466850775 0.00623834242130019 NA NA NA hsa-miR-181b-5p DENND4C 0.488256489401108 0.00105321129419701 -0.449333876796266 4.55066587024558e-06 MirTarget -0.117986711712167 0.000240486972135867 NA NA NA hsa-miR-19b-3p DENND4C 0.601279551368824 0.00016685097085251 -0.449333876796266 4.55066587024558e-06 MirTarget -0.133772336247006 7.04258884880786e-06 NA NA NA hsa-miR-455-3p DENND5A -1.3998033821095 5.72010709806871e-17 0.394981824614894 2.3234778263553e-06 miRNATAP -0.126597969281213 5.72512161816595e-08 NA NA NA hsa-miR-181a-5p DENND5B 0.250113435902954 0.0551933249319293 -0.618139309020725 4.9388184165447e-08 MirTarget;mirMAP -0.265527660867198 3.52507554117054e-10 NA NA NA hsa-miR-181b-5p DENND5B 0.488256489401108 0.00105321129419701 -0.618139309020725 4.9388184165447e-08 MirTarget;mirMAP -0.253407974729127 4.59295916203923e-12 NA NA NA hsa-miR-194-5p DEPDC1B -0.292530160992458 0.0996141384876663 2.81995289547286 3.64152756583752e-21 miRNATAP -0.258605556379842 0.00271626414657615 NA NA NA hsa-miR-27b-3p DEPDC1B -0.823491817819754 9.20935302746823e-14 2.81995289547286 3.64152756583752e-21 MirTarget -0.602856302949885 7.24923243948977e-06 NA NA NA hsa-miR-146b-5p DEPDC5 0.419719546795449 0.0457375823220155 -0.32305448900824 0.00441905864246784 miRanda -0.136860380087087 1.44246253192662e-07 NA NA NA hsa-miR-132-3p DEPDC7 0.323796239695997 0.00272093067935091 -1.67732789584739 2.69773016119405e-13 miRNAWalker2_validate -0.706824962773146 1.56536839544021e-11 NA NA NA hsa-miR-222-3p DERA 1.08574156066353 1.76407192348131e-11 -0.670216740166478 3.27001133185604e-10 miRNAWalker2_validate -0.26205850140215 2.06508298706159e-17 NA NA NA hsa-miR-181a-5p DERL1 0.250113435902954 0.0551933249319293 0.117647235923305 0.20253397831506 MirTarget;miRNATAP -0.13793192354648 5.83612857973373e-05 NA NA NA hsa-miR-181b-5p DERL1 0.488256489401108 0.00105321129419701 0.117647235923305 0.20253397831506 MirTarget;miRNATAP -0.142372595425966 1.67898859100791e-06 NA NA NA hsa-miR-19b-3p DERL1 0.601279551368824 0.00016685097085251 0.117647235923305 0.20253397831506 miRNAWalker2_validate -0.142200564304468 2.5887478066624e-07 NA NA NA hsa-miR-27b-3p DGCR14 -0.823491817819754 9.20935302746823e-14 0.507649776620343 1.75813829818611e-11 mirMAP -0.129981330854806 8.2165049316989e-05 NA NA NA hsa-miR-29c-3p DGCR2 -1.4367517608807 1.61767774905781e-21 0.480917046414169 4.64032272088744e-09 mirMAP -0.114301299602621 6.9252376192053e-06 NA NA NA hsa-miR-127-3p DGCR6 -1.0751374948053 2.19322892330221e-05 -0.335148708746183 0.0437459400339866 miRanda -0.105836567067818 0.000807907521784532 NA NA NA hsa-miR-455-5p DGKA -0.270546034117157 0.0581320703577731 0.171947370366045 0.350313389239957 miRanda -0.264136896508163 2.41565209308252e-05 NA NA NA hsa-miR-29c-3p DGKD -1.4367517608807 1.61767774905781e-21 0.711034021867333 8.46501341224824e-13 MirTarget;miRNATAP -0.24338737488773 1.06434152594802e-15 NA NA NA hsa-miR-505-5p DGKD -0.768282569967001 1.14662846595407e-05 0.711034021867333 8.46501341224824e-13 MirTarget -0.113224783674945 5.25824288438714e-05 NA NA NA hsa-miR-17-3p DGKE 0.410352776142368 0.00422200500748636 -0.855065779351597 4.0361991167554e-06 MirTarget -0.261948025922824 3.56788707709485e-05 NA NA NA hsa-miR-19b-3p DGKE 0.601279551368824 0.00016685097085251 -0.855065779351597 4.0361991167554e-06 MirTarget;miRNATAP -0.166983372396375 0.00334616361529621 NA NA NA hsa-miR-20a-5p DGKE 0.854326758727003 5.04256669663285e-07 -0.855065779351597 4.0361991167554e-06 MirTarget -0.234462315968758 8.71988897326527e-06 NA NA NA hsa-miR-221-3p DGKE 1.12244756358612 3.48370308238012e-13 -0.855065779351597 4.0361991167554e-06 miRNATAP -0.357373219511501 2.59209263594667e-10 NA NA NA hsa-miR-222-3p DGKE 1.08574156066353 1.76407192348131e-11 -0.855065779351597 4.0361991167554e-06 miRNATAP -0.237577254588055 1.52710102346772e-05 NA NA NA hsa-miR-455-5p DGKE -0.270546034117157 0.0581320703577731 -0.855065779351597 4.0361991167554e-06 MirTarget;miRanda -0.244816812444849 0.000128136112943223 NA NA NA hsa-miR-192-3p DGKG -0.6401165114007 0.000266272092403814 -0.360347187415291 0.169251151377798 mirMAP -0.304985698081316 2.24012125069149e-05 NA NA NA hsa-miR-30c-5p DGKH -0.432111642767632 0.000159764714931007 0.210341644336773 0.0696965426298757 MirTarget -0.170649790852051 0.000521364994089255 NA NA NA hsa-miR-30c-5p DGKZ -0.432111642767632 0.000159764714931007 0.732808180745531 1.57387360194658e-17 MirTarget;miRNATAP -0.161484512810345 1.91675964034141e-05 NA NA NA hsa-miR-30e-5p DGKZ -0.627815042856657 3.02205690184908e-10 0.732808180745531 1.57387360194658e-17 MirTarget -0.286650995443687 1.04662590390766e-11 NA NA NA hsa-miR-503-5p DHCR24 0.191949282338049 0.268420664548092 -0.296400686970518 0.02120923867843 MirTarget -0.133441453645811 0.000218517529501072 NA NA NA hsa-miR-19b-3p DHX40 0.601279551368824 0.00016685097085251 -0.118232522860019 0.195443271490095 miRNATAP -0.14501549874362 1.06015136181697e-07 NA NA NA hsa-miR-30b-5p DHX40 -0.54056186708617 2.44688760798341e-05 -0.118232522860019 0.195443271490095 MirTarget -0.135393776146975 7.88593548163008e-05 NA NA NA hsa-miR-455-5p DHX40 -0.270546034117157 0.0581320703577731 -0.118232522860019 0.195443271490095 miRNATAP -0.113786046909209 0.000244386843736278 NA NA NA hsa-miR-15a-5p DIAPH1 0.349521211668244 0.000770735998804736 -0.401899970495966 2.22782677309071e-05 MirTarget -0.132100839402758 0.0032381868039818 NA NA NA hsa-miR-181b-5p DIAPH1 0.488256489401108 0.00105321129419701 -0.401899970495966 2.22782677309071e-05 mirMAP -0.2822980294356 1.59048713253967e-21 NA NA NA hsa-miR-17-3p DIAPH2 0.410352776142368 0.00422200500748636 -0.328796656964736 0.00404652455620109 miRNAWalker2_validate -0.159264141923404 3.88049586340006e-05 NA NA NA hsa-miR-30b-5p DIO2 -0.54056186708617 2.44688760798341e-05 1.74798259848111 3.86024401348235e-05 mirMAP;miRNATAP -0.516312782289766 0.00145369857080391 NA NA NA hsa-miR-181a-5p DIP2C 0.250113435902954 0.0551933249319293 -0.777858675870751 4.97084735087691e-05 MirTarget;miRNATAP -0.313645394617314 1.33396286383963e-05 NA NA NA hsa-miR-181b-5p DIP2C 0.488256489401108 0.00105321129419701 -0.777858675870751 4.97084735087691e-05 MirTarget;miRNATAP -0.276723694674535 9.95957435216485e-06 NA NA NA hsa-miR-19b-3p DIP2C 0.601279551368824 0.00016685097085251 -0.777858675870751 4.97084735087691e-05 miRNATAP -0.171569335988817 0.00344894677989445 NA NA NA hsa-miR-20a-5p DIP2C 0.854326758727003 5.04256669663285e-07 -0.777858675870751 4.97084735087691e-05 miRNATAP -0.251988168401984 3.45920914574403e-06 NA NA NA hsa-miR-455-5p DIP2C -0.270546034117157 0.0581320703577731 -0.777858675870751 4.97084735087691e-05 miRanda -0.131991421260681 0.0465282024815954 NA NA NA hsa-miR-29c-3p DIRAS1 -1.4367517608807 1.61767774905781e-21 1.55100938428268 4.69784557391614e-05 mirMAP -0.445950161963568 0.00015365398332915 NA NA NA hsa-miR-221-3p DIRAS3 1.12244756358612 3.48370308238012e-13 -4.17016298624992 2.73003492088956e-33 miRTarBase -0.985400240957357 7.11911280907473e-19 21071579;23801152;22117988 Further studies on a new mechanism of ARHI downregulation showed a significant inverse relationship between ARHI and miR-221 and 222 which were upregulated in prostate cancer cell lines; Transfection of miR-221 and 222 inhibitors into PC-3 cells caused a significant induction of ARHI expression; A direct interaction of miR-221 or 222 with a target site on the 3'UTR of ARHI was confirmed by a dual luciferase pMIR-REPORT assay; Finally we also found that genistein upregulates ARHI by downregulating miR-221 and 222 in PC-3 cells;Effects of ARHI on breast cancer cell biological behavior regulated by microRNA 221; The downregulation of ARHI was regulated by miR-221 in prostate cancer cell lines; However it has not been reported whether ARHI is regulated by miR-221 in breast cancer; To address whether ARHI is regulated by miR-221 in breast cancer cell lines the results in this study showed that a significant inverse correlation existed between ARHI and miR-221; The inhibition of miR-221 induced a significant upregulation of ARHI in MCF-7 cells; To prove a direct interaction between miR-221 and ARHI mRNA ARHI 3'UTR which includes the potential target site for miR-221 was cloned downstream of the luciferase reporter gene of the pMIR-REPORT vector to generate the pMIR-ARHI-3'UTR vector; The results confirmed a direct interaction of miR-221 with a target site on the 3'UTR of ARHI; This study demonstrated for the first time that the downregulation of ARHI in breast cancer cells could be regulated by miR-221;MicroRNA 221 and 222 have been shown to regulate ARHI expression negatively; Expression of ARHI and microRNA 221 and 222 was measured by real-time reverse transcription-polymerase chain reaction; Whether ARHI and microRNA 221 and 222 could be considered as biomarkers for disease progression in prostate cancer requires further investigation ;;progression prostate cancer;breast cancer;prostate cancer hsa-miR-222-3p DIRAS3 1.08574156066353 1.76407192348131e-11 -4.17016298624992 2.73003492088956e-33 miRTarBase -0.84025850970062 6.01836344622582e-15 NA NA NA hsa-miR-20a-5p DIRC2 0.854326758727003 5.04256669663285e-07 -0.0583843779576894 0.490426282360048 MirTarget;miRNATAP -0.217969462965237 7.28336614394969e-22 NA NA NA hsa-miR-146b-5p DIS3L 0.419719546795449 0.0457375823220155 -0.312319132355653 0.000448366711945419 miRanda -0.108332819327842 1.109889947545e-07 NA NA NA hsa-miR-194-5p DISC1 -0.292530160992458 0.0996141384876663 -0.0478074033519262 0.793823181607198 MirTarget -0.345560591255119 1.59201568054397e-12 NA NA NA hsa-miR-15a-5p DIXDC1 0.349521211668244 0.000770735998804736 -1.03337855682211 1.80344543578202e-10 MirTarget -0.235820922669781 0.00248146296782177 NA NA NA hsa-miR-181a-5p DIXDC1 0.250113435902954 0.0551933249319293 -1.03337855682211 1.80344543578202e-10 mirMAP -0.15647615110565 0.0118746900197173 NA NA NA hsa-miR-181b-5p DIXDC1 0.488256489401108 0.00105321129419701 -1.03337855682211 1.80344543578202e-10 mirMAP -0.179992547275748 0.00084859759025075 NA NA NA hsa-miR-20a-5p DIXDC1 0.854326758727003 5.04256669663285e-07 -1.03337855682211 1.80344543578202e-10 mirMAP -0.281889296972183 9.60235865890741e-10 NA NA NA hsa-miR-20b-5p DIXDC1 0.457668023910379 0.0285865211936156 -1.03337855682211 1.80344543578202e-10 mirMAP -0.110169126260847 0.00426326468895077 NA NA NA hsa-miR-455-5p DKK2 -0.270546034117157 0.0581320703577731 0.712159035258033 0.0313122411685687 miRanda -0.451655268783954 6.27129067973938e-05 NA NA NA hsa-miR-19b-3p DKK3 0.601279551368824 0.00016685097085251 0.261595737055162 0.276632540684522 miRNATAP -0.292435874309854 5.62218485502241e-05 NA NA NA hsa-miR-455-3p DKK3 -1.3998033821095 5.72010709806871e-17 0.261595737055162 0.276632540684522 PITA -0.168315109147889 0.0126033297633948 NA NA NA hsa-miR-181b-5p DLC1 0.488256489401108 0.00105321129419701 -1.42279739514993 6.69575982669214e-23 mirMAP -0.131453198036123 0.0082874541581851 NA NA NA hsa-miR-19b-3p DLC1 0.601279551368824 0.00016685097085251 -1.42279739514993 6.69575982669214e-23 mirMAP;miRNATAP -0.17326129142917 0.000172837161631576 NA NA NA hsa-miR-20a-5p DLC1 0.854326758727003 5.04256669663285e-07 -1.42279739514993 6.69575982669214e-23 miRNAWalker2_validate;miRNATAP -0.177390403581051 3.6245603031967e-05 NA NA NA hsa-miR-21-5p DLG1 1.51084295924322 1.54551622173259e-34 -0.138873477942219 0.0841159694184806 miRNAWalker2_validate -0.189341396834391 3.40040140631564e-11 NA NA NA hsa-miR-146b-5p DLG2 0.419719546795449 0.0457375823220155 -1.94736926226419 3.34813832074824e-14 miRanda -0.136862887250907 0.0262563136399173 NA NA NA hsa-miR-182-5p DLG2 1.96601340710222 4.39326175603633e-09 -1.94736926226419 3.34813832074824e-14 miRNATAP -0.102326912137778 0.00679899154112103 NA NA NA hsa-miR-19b-3p DLG2 0.601279551368824 0.00016685097085251 -1.94736926226419 3.34813832074824e-14 mirMAP -0.227850181928977 0.00467340085902087 NA NA NA hsa-miR-20a-5p DLG2 0.854326758727003 5.04256669663285e-07 -1.94736926226419 3.34813832074824e-14 mirMAP -0.365285100773836 9.13655135441683e-07 NA NA NA hsa-miR-192-5p DLG5 -0.50188499512787 0.00344713341196035 1.50511854034316 3.93408903539969e-21 miRNAWalker2_validate -0.159449173907036 0.000775276233348482 NA NA NA hsa-miR-215-5p DLG5 -0.981544773246509 3.14452272477156e-05 1.50511854034316 3.93408903539969e-21 miRNAWalker2_validate -0.232378328822028 4.17801717253643e-12 NA NA NA hsa-miR-30c-5p DLG5 -0.432111642767632 0.000159764714931007 1.50511854034316 3.93408903539969e-21 miRNATAP -0.186149156720118 0.00921002112781085 NA NA NA hsa-miR-30e-5p DLGAP4 -0.627815042856657 3.02205690184908e-10 0.616384781844966 4.24155614328603e-13 MirTarget -0.26602554409032 1.20002136282784e-10 NA NA NA hsa-miR-192-5p DLGAP5 -0.50188499512787 0.00344713341196035 4.10741783900744 2.38289419329605e-47 miRNAWalker2_validate -0.202888895855437 0.0254710736562676 NA NA NA hsa-miR-215-5p DLGAP5 -0.981544773246509 3.14452272477156e-05 4.10741783900744 2.38289419329605e-47 miRNAWalker2_validate -0.139466565972432 0.033555169853703 NA NA NA hsa-miR-146b-5p DLL1 0.419719546795449 0.0457375823220155 -0.548830846531552 0.0160272291862025 miRanda -0.175688247040319 0.000878870145815347 NA NA NA hsa-miR-15a-5p DLL1 0.349521211668244 0.000770735998804736 -0.548830846531552 0.0160272291862025 miRNATAP -0.367212146758552 0.000619658629327403 NA NA NA hsa-miR-27b-3p DLL4 -0.823491817819754 9.20935302746823e-14 1.07379585219093 2.85322047024912e-15 miRNATAP -0.153412966174776 0.011415697218425 NA NA NA hsa-miR-30c-5p DLL4 -0.432111642767632 0.000159764714931007 1.07379585219093 2.85322047024912e-15 miRNATAP -0.174410218216806 0.003592820944387 NA NA NA hsa-miR-505-5p DMBX1 -0.768282569967001 1.14662846595407e-05 1.32448000928066 6.92609588264051e-05 mirMAP -0.453205383276245 7.71008897334028e-07 NA NA NA hsa-miR-20a-5p DMD 0.854326758727003 5.04256669663285e-07 -1.6618166260325 2.70344741582688e-17 mirMAP -0.275398809271483 1.6121705940957e-06 NA NA NA hsa-miR-21-5p DMD 1.51084295924322 1.54551622173259e-34 -1.6618166260325 2.70344741582688e-17 miRNAWalker2_validate -0.770128026941647 2.69472437841492e-28 NA NA NA hsa-miR-132-3p DMGDH 0.323796239695997 0.00272093067935091 -2.32013955738422 1.57455346616401e-15 miRNAWalker2_validate -1.01613326727826 1.9559842213094e-14 NA NA NA hsa-miR-148a-3p DMPK -0.748702855596996 3.93313343865641e-07 0.656614767219979 1.80881732624839e-07 MirTarget -0.30785961316669 2.61560071271051e-14 NA NA NA hsa-miR-455-5p DMXL1 -0.270546034117157 0.0581320703577731 -0.303980292854454 0.00262015559931254 miRanda -0.141335330732079 4.03243909472966e-05 NA NA NA hsa-miR-27b-3p DMXL2 -0.823491817819754 9.20935302746823e-14 0.350388524150803 0.00209064181253301 miRNATAP -0.122751476742272 0.0125750712949817 NA NA NA hsa-miR-132-3p DNAJA2 0.323796239695997 0.00272093067935091 -0.306446654215278 0.000859844830484026 miRNATAP -0.109401764012393 0.00880804157823342 NA NA NA hsa-miR-15a-5p DNAJA2 0.349521211668244 0.000770735998804736 -0.306446654215278 0.000859844830484026 miRNATAP -0.124916432351485 0.00395862096318468 NA NA NA hsa-miR-19b-3p DNAJA2 0.601279551368824 0.00016685097085251 -0.306446654215278 0.000859844830484026 miRNAWalker2_validate;miRNATAP -0.163765664038541 2.61820434313164e-09 NA NA NA hsa-miR-29c-3p DNAJB11 -1.4367517608807 1.61767774905781e-21 0.853927523668179 2.13811491658948e-21 miRNATAP -0.16152556444309 1.63509301039585e-08 NA NA NA hsa-miR-19b-3p DNAJB14 0.601279551368824 0.00016685097085251 -0.327204840089198 0.00343768514090228 mirMAP -0.199903831866017 2.27742153353488e-09 NA NA NA hsa-miR-192-5p DNAJB5 -0.50188499512787 0.00344713341196035 0.366457775682137 0.000167813461757478 miRNAWalker2_validate -0.164090642735937 1.69105367324604e-09 NA NA NA hsa-miR-20a-5p DNAJB9 0.854326758727003 5.04256669663285e-07 -0.631181264981697 8.66249196538849e-07 miRNATAP -0.20096568172869 2.96222695664608e-08 NA NA NA hsa-miR-30b-5p DNAJC13 -0.54056186708617 2.44688760798341e-05 0.178657241654522 0.0236307003815148 MirTarget -0.130448811070332 1.04411840386826e-05 NA NA NA hsa-miR-455-5p DNAJC13 -0.270546034117157 0.0581320703577731 0.178657241654522 0.0236307003815148 miRanda -0.152024827114363 9.92745872773945e-09 NA NA NA hsa-miR-148a-3p DNAJC18 -0.748702855596996 3.93313343865641e-07 0.379578184862879 0.00785785435417525 MirTarget -0.482256465265997 2.60755726904746e-28 NA NA NA hsa-miR-192-3p DNAJC18 -0.6401165114007 0.000266272092403814 0.379578184862879 0.00785785435417525 mirMAP -0.377707784163816 5.11680747301645e-24 NA NA NA hsa-miR-20a-5p DNAJC27 0.854326758727003 5.04256669663285e-07 -0.350802101061359 0.000255703839327469 MirTarget;miRNATAP -0.140515052548109 1.83689397879291e-07 NA NA NA hsa-miR-29c-3p DNAJC5 -1.4367517608807 1.61767774905781e-21 0.729723241275518 1.53708391771805e-17 mirMAP -0.214502238552896 4.61771468136897e-16 NA NA NA hsa-miR-27b-3p DNAJC5B -0.823491817819754 9.20935302746823e-14 -0.393343492416372 0.121626961014019 miRNATAP -0.220345017711243 0.0445644618528854 NA NA NA hsa-miR-192-5p DNAL1 -0.50188499512787 0.00344713341196035 -0.0875635311142695 0.300992092038673 miRNAWalker2_validate -0.198548317578036 4.84586710712504e-18 NA NA NA hsa-miR-148a-3p DNER -0.748702855596996 3.93313343865641e-07 1.29255242782277 0.00336209766653278 MirTarget;miRNATAP -1.04467659125513 1.06494193352452e-13 NA NA NA hsa-miR-30e-5p DNM3 -0.627815042856657 3.02205690184908e-10 1.36736147579245 1.02047986055836e-15 mirMAP -0.209665261014427 0.0141297227438758 NA NA NA hsa-miR-132-3p DNMBP 0.323796239695997 0.00272093067935091 -0.66456706009434 1.57585783411954e-08 MirTarget -0.275303179941975 2.70158500535832e-07 NA NA NA hsa-miR-148a-3p DNMT1 -0.748702855596996 3.93313343865641e-07 1.07072601011042 3.56408109602049e-16 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.222357078113257 4.38571155341952e-07 25865490;26111756;25950085;22167392 miR 148a dependent apoptosis of bladder cancer cells is mediated in part by the epigenetic modifier DNMT1; We additionally show that miR-148a exerts this effect partially by attenuating expression of DNA methyltransferase 1 DNMT1;Moreover we found that miR-148a appeared to be a target of bufalin and miR-148a further regulated DNMT1 and p27 to control the stemness of OS cells;The Interplay Between miR 148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy; We discovered the expression level of miR-148a significantly decreased in pancreatic cancer tissues whereas that of DNMT1 increased; In ASPC-1 cancer cells the overexpression of miR-148a led to a decreased level of DNMT1 and reduced the proliferation and metastasis of ASPC-1 cells; Interestingly it was shown that the DNMT1 inhibition enhanced the expression of miR-148a; In vivo studies demonstrated that the tumorigenesis of ASPC-1 was significantly arrested by either the overexpression of miR-148a or the inhibition of DNMT1;Studies have shown that microRNA-148a miR-148a was proved to be silenced while DNA methyltransferase 1 DNMT1 was over-expressed in gastric cancer; But the mechanism of aberrant expression of miR-148a and DNMT1 and their relationships in gastric cancer are still unknown; The aims of this study were to investigate the expression profile of miR-148a and DNMT1 and reveal whether they have any relationships; We used reverse-transcriptase quantitative real-time PCR methylation-specific PCR and Western blot to measure the level of miR-148a expression DNA methylation level and DNMT1 expression respectively; DNMT1 was over-expressed in primary tumors and cell lines while knockdown of DNMT1 using siRNA could decrease methylation level of miR-148a promoter and restore its expression; Furthermore ectopic over-expression of miR-148a in cancer cell lines caused reduction in DNMT1 expression and inhibited cell proliferation but no obvious change was found in apoptosis rate; These results suggest that miR-148a is inactivated by DNA hypermethylation of promoter region in gastric cancer which is mediated through DNMT1 over-expression; Additionally the silence of miR-148a reduces its suppression to DNMT1 in gastric cancer and this may in turn result in over-expression of DNMT1 and promote DNA hypermethylation ;;metastasis;tumorigenesis; bladder cancer;sarcoma;pancreatic cancer;gastric cancer hsa-miR-30b-5p DNMT1 -0.54056186708617 2.44688760798341e-05 1.07072601011042 3.56408109602049e-16 miRNAWalker2_validate -0.119890371274427 0.0203544236610841 24913034 Decreased miR 30b 5p expression by DNMT1 methylation regulation involved in gastric cancer metastasis; The level of miR-30b-5p may be restored by DNA demethylation and DNMT1 induced miR-30b-5p promoter methylation metastasis gastric cancer hsa-miR-29c-3p DNMT3A -1.4367517608807 1.61767774905781e-21 1.18820126942617 6.93286101815213e-19 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.528551841163263 3.45450033944761e-42 21081840 Overall an increase in miR-29c expression inversely correlated to both DNMT3A and DNMT3B protein expression in melanomas melanoma hsa-miR-30c-5p DNMT3A -0.432111642767632 0.000159764714931007 1.18820126942617 6.93286101815213e-19 MirTarget;miRNATAP -0.1394134255833 0.0194086535671629 NA NA NA hsa-miR-30e-5p DNMT3A -0.627815042856657 3.02205690184908e-10 1.18820126942617 6.93286101815213e-19 MirTarget -0.265087767439435 8.0916949331952e-05 NA NA NA hsa-miR-148a-3p DNMT3B -0.748702855596996 3.93313343865641e-07 1.61793226634891 7.24162651287187e-19 miRNAWalker2_validate;miRTarBase -0.192692774033865 0.00195212252979673 20841507 Low ERG expressers presented with down-regulation of genes involved in the DNA-methylation machinery and up-regulation of miR-148a which targets DNMT3B acute myeloid leukemia hsa-miR-29c-3p DNMT3B -1.4367517608807 1.61767774905781e-21 1.61793226634891 7.24162651287187e-19 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.562308323582278 3.86742126393607e-24 21081840 Overall an increase in miR-29c expression inversely correlated to both DNMT3A and DNMT3B protein expression in melanomas; Expression of DNMT3B and miR-29c were significantly p=0.004 and p=0.002 respectively associated with overall survivalOS in AJCC stage III melanoma patients by multivariate analysis; The studies demonstrated that both miR-29c and DNMT3B have significant roles in melanoma progression and may be useful epigenetic biomarkers for disease outcome staging;poor survival;progression melanoma hsa-miR-146b-5p DOCK1 0.419719546795449 0.0457375823220155 -0.334142630820963 0.0330893798122011 miRanda -0.105369671252715 0.00373568926388722 NA NA NA hsa-miR-19b-3p DOCK10 0.601279551368824 0.00016685097085251 -1.11247888855297 1.81436882873985e-07 miRNATAP -0.16125664942486 0.0142132779973189 NA NA NA hsa-miR-455-5p DOCK10 -0.270546034117157 0.0581320703577731 -1.11247888855297 1.81436882873985e-07 miRanda -0.383677106668839 1.58855148626623e-07 NA NA NA hsa-miR-148a-3p DOCK3 -0.748702855596996 3.93313343865641e-07 1.89917396490138 8.65073654235979e-17 miRNATAP -0.283819265304344 0.000239484898895635 NA NA NA hsa-miR-181a-5p DOCK4 0.250113435902954 0.0551933249319293 -0.196572963974556 0.0730533705216442 MirTarget -0.120816553369754 0.00324108219118675 NA NA NA hsa-miR-20a-5p DOCK4 0.854326758727003 5.04256669663285e-07 -0.196572963974556 0.0730533705216442 MirTarget -0.136682179554845 8.95116115068355e-06 NA NA NA hsa-miR-21-5p DOCK4 1.51084295924322 1.54551622173259e-34 -0.196572963974556 0.0730533705216442 miRNAWalker2_validate;miRTarBase -0.112445237932462 0.00485054593393611 NA NA NA hsa-miR-30b-5p DOCK4 -0.54056186708617 2.44688760798341e-05 -0.196572963974556 0.0730533705216442 mirMAP -0.151069519126087 0.000257244595032846 NA NA NA hsa-miR-455-5p DOCK4 -0.270546034117157 0.0581320703577731 -0.196572963974556 0.0730533705216442 PITA;miRanda -0.153546920769983 3.76898566259177e-05 NA NA NA hsa-miR-146b-5p DOCK5 0.419719546795449 0.0457375823220155 -0.642812791721581 0.000979588907494083 miRanda -0.215538243567158 1.66694289649102e-06 NA NA NA hsa-miR-19b-3p DOCK5 0.601279551368824 0.00016685097085251 -0.642812791721581 0.000979588907494083 MirTarget -0.161515653338813 0.00664808117344485 NA NA NA hsa-miR-21-5p DOCK5 1.51084295924322 1.54551622173259e-34 -0.642812791721581 0.000979588907494083 miRNAWalker2_validate;miRTarBase -0.250802976494196 0.000433372119735922 NA NA NA hsa-miR-222-3p DOCK5 1.08574156066353 1.76407192348131e-11 -0.642812791721581 0.000979588907494083 miRNAWalker2_validate -0.131772905126665 0.022774528291384 NA NA NA hsa-miR-455-5p DOCK5 -0.270546034117157 0.0581320703577731 -0.642812791721581 0.000979588907494083 miRanda -0.281330287824553 2.44271174563905e-05 NA NA NA hsa-miR-148a-3p DOCK6 -0.748702855596996 3.93313343865641e-07 0.921029085267333 4.1395349862803e-24 MirTarget -0.242316323155687 1.46606073675809e-15 NA NA NA hsa-miR-181a-5p DOCK7 0.250113435902954 0.0551933249319293 0.0354510785273701 0.747532702005791 MirTarget;miRNATAP -0.113825558280494 0.00568959380699761 NA NA NA hsa-miR-30b-5p DOCK7 -0.54056186708617 2.44688760798341e-05 0.0354510785273701 0.747532702005791 MirTarget -0.220100634574084 8.27395505286496e-08 NA NA NA hsa-miR-455-5p DOCK7 -0.270546034117157 0.0581320703577731 0.0354510785273701 0.747532702005791 miRanda -0.135818063018183 0.000285331534698392 NA NA NA hsa-miR-455-5p DOCK9 -0.270546034117157 0.0581320703577731 -0.0562179943872674 0.673245642901786 MirTarget;PITA;miRanda;miRNATAP -0.141632809377596 0.00183295866473378 NA NA NA hsa-miR-192-5p DOK6 -0.50188499512787 0.00344713341196035 -1.91134260561967 2.47519280623105e-09 mirMAP -0.307832195941665 0.000873173634559653 NA NA NA hsa-miR-21-5p DOK6 1.51084295924322 1.54551622173259e-34 -1.91134260561967 2.47519280623105e-09 mirMAP -0.470056189254098 7.50851899469102e-05 NA NA NA hsa-miR-148a-3p DOT1L -0.748702855596996 3.93313343865641e-07 0.585703387018246 2.71031330751421e-07 mirMAP -0.105927324502338 0.00490233486966271 NA NA NA hsa-miR-29c-3p DOT1L -1.4367517608807 1.61767774905781e-21 0.585703387018246 2.71031330751421e-07 MirTarget;miRNATAP -0.293638083074286 7.32340173958927e-18 NA NA NA hsa-miR-455-5p DPEP2 -0.270546034117157 0.0581320703577731 -1.17940916210468 5.29584542991946e-11 miRanda -0.170418256409671 0.00683393567880514 NA NA NA hsa-miR-182-5p DPF3 1.96601340710222 4.39326175603633e-09 -2.58738288059242 1.74995213728726e-21 mirMAP -0.163099007204789 5.85450395943741e-05 NA NA NA hsa-miR-148a-3p DPP3 -0.748702855596996 3.93313343865641e-07 0.367930824003208 7.7340018984217e-06 miRNATAP -0.13173717479097 8.52306013192258e-07 NA NA NA hsa-miR-221-3p DPP8 1.12244756358612 3.48370308238012e-13 -0.274761779428937 0.0691793168762807 MirTarget -0.104806082957886 0.0242641125646373 NA NA NA hsa-miR-30b-5p DPP8 -0.54056186708617 2.44688760798341e-05 -0.274761779428937 0.0691793168762807 mirMAP -0.205727860867706 0.000313626540077283 NA NA NA hsa-miR-17-3p DPT 0.410352776142368 0.00422200500748636 -4.36309973983215 2.02924136973829e-20 MirTarget -0.369544222923814 0.0283056782308703 NA NA NA hsa-miR-455-5p DPY19L3 -0.270546034117157 0.0581320703577731 -0.379253834608332 0.0412954227879793 miRanda -0.226275630400076 0.000363773877147548 NA NA NA hsa-miR-20a-5p DPYSL2 0.854326758727003 5.04256669663285e-07 -0.459626007194783 0.000892653964210093 MirTarget;miRNATAP -0.330848399343528 1.93357247682817e-18 NA NA NA hsa-miR-29c-3p DSC2 -1.4367517608807 1.61767774905781e-21 -0.618654593947357 0.000820559055966933 MirTarget -0.305662570397354 6.08318681646291e-08 NA NA NA hsa-miR-15a-5p DSEL 0.349521211668244 0.000770735998804736 -1.55071531718368 6.25577121966913e-09 MirTarget;miRNATAP -0.4141635087333 0.00119990556811216 NA NA NA hsa-miR-146b-5p DST 0.419719546795449 0.0457375823220155 -0.376077518150669 0.00154802384484121 miRanda -0.115846477778592 2.419088044855e-05 NA NA NA hsa-miR-21-5p DST 1.51084295924322 1.54551622173259e-34 -0.376077518150669 0.00154802384484121 mirMAP -0.192141258894703 8.41432997112948e-06 22403704 While the EDCs and estrogen similarly altered the expression of multiple microRNAs in MCF-7 cells including miR-21 differential patterns of microRNA expression were induced by DDT and BPA compared to estrogen breast cancer hsa-miR-455-5p DSTN -0.270546034117157 0.0581320703577731 -0.149659441213252 0.0711427871720715 miRanda -0.124704529317035 8.85321377623812e-06 NA NA NA hsa-miR-148a-3p DSTYK -0.748702855596996 3.93313343865641e-07 1.00504202460505 2.41375496861128e-19 miRNAWalker2_validate -0.200328046355734 1.06054134520476e-07 NA NA NA hsa-miR-192-5p DSTYK -0.50188499512787 0.00344713341196035 1.00504202460505 2.41375496861128e-19 miRNAWalker2_validate -0.26635143039323 6.98100480748641e-17 NA NA NA hsa-miR-30e-5p DSTYK -0.627815042856657 3.02205690184908e-10 1.00504202460505 2.41375496861128e-19 MirTarget -0.238743307125572 2.07192322523506e-05 NA NA NA hsa-miR-215-5p DTL -0.981544773246509 3.14452272477156e-05 3.44226759429604 9.90217851205717e-45 miRNAWalker2_validate -0.121578119424086 0.0306944251705116 21752725;20433742 miR-215 is a tumor suppressor candidate due to the upregulation of p53 and p21 by targeting DTL; However high levels of miR-215 conferred chemoresistance due to cell cycle arrest and reduced cell proliferation by suppressing DTL; DTL was significantly over-expressed and was inversely correlated with miR-215 further suggesting an in vivo physiologic relevance of miR-215 mediated DTL suppression; Furthermore an elevated expression of a miR-215 target protein DTL was detected in colon cancer tissues whereas no expression was present in normal tissues;Taken together our results indicate that miR-215 through the suppression of DTL expression induces a decreased cell proliferation by causing G2-arrest thereby leading to an increase in chemoresistance to MTX and TDX drug resistance;drug resistance colon cancer;sarcoma hsa-miR-148a-3p DTNA -0.748702855596996 3.93313343865641e-07 1.85440917822318 1.2434230849807e-10 miRNATAP -0.419016677215032 1.19731795266872e-05 NA NA NA hsa-miR-27b-3p DTNA -0.823491817819754 9.20935302746823e-14 1.85440917822318 1.2434230849807e-10 MirTarget;miRNATAP -0.297124202192461 0.0195354631628679 NA NA NA hsa-miR-455-5p DTNA -0.270546034117157 0.0581320703577731 1.85440917822318 1.2434230849807e-10 miRanda -0.258546778135672 0.0105151773465625 NA NA NA hsa-miR-132-3p DTWD2 0.323796239695997 0.00272093067935091 -0.416234660342353 0.000228815065008349 mirMAP -0.178963496950209 0.000485274922762982 NA NA NA hsa-miR-21-5p DUSP10 1.51084295924322 1.54551622173259e-34 -1.25031678861182 9.23323170092562e-16 miRNAWalker2_validate;miRTarBase -0.33582473632279 6.72233513653455e-09 NA NA NA hsa-miR-505-5p DUSP15 -0.768282569967001 1.14662846595407e-05 0.484513855936604 0.145314143341741 MirTarget -0.201235388162269 0.0286694057087901 NA NA NA hsa-miR-455-5p DUSP18 -0.270546034117157 0.0581320703577731 0.521402838825816 1.31734329988244e-05 miRanda -0.244816834178647 1.62573540670962e-09 NA NA NA hsa-miR-17-3p DUSP19 0.410352776142368 0.00422200500748636 -0.328303309759416 0.00807962546161295 mirMAP -0.127598642691221 0.00245377083923086 NA NA NA hsa-miR-15a-5p DUSP3 0.349521211668244 0.000770735998804736 0.0872836900439955 0.276723760000984 MirTarget;miRNATAP -0.145054839460179 0.000105362750446951 NA NA NA hsa-miR-192-3p DUSP4 -0.6401165114007 0.000266272092403814 -0.0822318791590862 0.744228977818766 mirMAP -0.532579059848036 2.48325221024225e-15 NA NA NA hsa-miR-20b-5p DUSP8 0.457668023910379 0.0285865211936156 0.597479289630443 0.00290374045782047 MirTarget;miRNATAP -0.177462429238997 0.000144067841699229 NA NA NA hsa-miR-505-5p DUSP8 -0.768282569967001 1.14662846595407e-05 0.597479289630443 0.00290374045782047 mirMAP -0.109207110116454 0.0498764255622515 NA NA NA hsa-miR-99a-5p DUSP9 -1.51481656384839 3.93230057259529e-14 3.1269142024265 1.25405437803303e-16 mirMAP -0.717445128410628 1.12779438331928e-15 NA NA NA hsa-miR-27b-3p DVL2 -0.823491817819754 9.20935302746823e-14 0.932937814675565 4.78146420278758e-20 miRNATAP -0.221394297021235 1.09073127725023e-06 NA NA NA hsa-miR-455-3p DYNC1H1 -1.3998033821095 5.72010709806871e-17 0.54022065131203 1.45925457972054e-14 miRNAWalker2_validate -0.152090219862722 9.22396084366991e-15 NA NA NA hsa-miR-182-5p DYNC1I1 1.96601340710222 4.39326175603633e-09 1.66864494169359 1.46552904583527e-05 MirTarget -0.123257474000718 0.0263908751821537 NA NA NA hsa-miR-192-3p DYNC1LI2 -0.6401165114007 0.000266272092403814 -0.0593819216914442 0.412674243061 MirTarget -0.13684438937209 1.6393924776309e-12 NA NA NA hsa-miR-19b-3p DYNC1LI2 0.601279551368824 0.00016685097085251 -0.0593819216914442 0.412674243061 MirTarget -0.117228216766889 5.44687977720204e-08 NA NA NA hsa-miR-20a-5p DYNC1LI2 0.854326758727003 5.04256669663285e-07 -0.0593819216914442 0.412674243061 MirTarget;miRNATAP -0.121628876378183 1.2491959709815e-09 NA NA NA hsa-miR-455-5p DYNC1LI2 -0.270546034117157 0.0581320703577731 -0.0593819216914442 0.412674243061 MirTarget;PITA;miRanda;miRNATAP -0.121847998092387 5.75922305330907e-07 NA NA NA hsa-miR-27b-3p DYNC2LI1 -0.823491817819754 9.20935302746823e-14 0.33945373719519 5.25531155032593e-05 MirTarget -0.122980208954955 0.000681994547554579 NA NA NA hsa-miR-19b-3p DYNLL2 0.601279551368824 0.00016685097085251 -0.626535692486098 7.86372375431067e-08 miRNAWalker2_validate;MirTarget -0.151880071825845 2.09131018413899e-05 NA NA NA hsa-miR-148a-3p DYRK1B -0.748702855596996 3.93313343865641e-07 0.432980103635144 0.000665367161987308 miRNATAP -0.226263129684861 3.85397710195182e-08 NA NA NA hsa-miR-455-3p DYRK2 -1.3998033821095 5.72010709806871e-17 0.389542654251892 0.00213564801591695 PITA -0.129262362127877 0.000278011774107997 NA NA NA hsa-miR-192-5p DYRK3 -0.50188499512787 0.00344713341196035 -0.123384598809894 0.439896233886906 MirTarget;miRNATAP -0.29301169186636 3.46788053219141e-11 NA NA NA hsa-miR-15a-5p DZIP1 0.349521211668244 0.000770735998804736 -0.753653256285659 0.0026006219518212 MirTarget -0.274955450529585 0.0203337665829265 NA NA NA hsa-miR-455-5p DZIP1 -0.270546034117157 0.0581320703577731 -0.753653256285659 0.0026006219518212 miRanda -0.211277812490015 0.0141350461653827 NA NA NA hsa-miR-214-5p E2F2 -1.91497809567701 3.92955595018147e-12 2.82262179260901 6.90997126839698e-33 MirTarget;miRNATAP -0.177970455644998 6.17643330181357e-05 NA NA NA hsa-miR-148a-3p E2F3 -0.748702855596996 3.93313343865641e-07 0.679179223655044 3.98775697474768e-07 miRNATAP -0.286439887340466 4.00406934916546e-11 NA NA NA hsa-miR-194-5p E2F3 -0.292530160992458 0.0996141384876663 0.679179223655044 3.98775697474768e-07 miRNATAP -0.170298851438611 4.06002835298195e-06 NA NA NA hsa-miR-455-5p E2F3 -0.270546034117157 0.0581320703577731 0.679179223655044 3.98775697474768e-07 miRanda -0.124732321929516 0.00724459816666969 NA NA NA hsa-miR-192-5p E2F5 -0.50188499512787 0.00344713341196035 0.730554652437087 0.000401890915871585 miRNAWalker2_validate -0.165569976807069 0.00489423335560786 NA NA NA hsa-miR-27b-3p E2F6 -0.823491817819754 9.20935302746823e-14 0.329712583456323 5.20721454340624e-05 miRNATAP -0.109439121091417 0.00186337699356186 NA NA NA hsa-miR-148a-3p E2F7 -0.748702855596996 3.93313343865641e-07 3.06815276582178 3.19808997821633e-30 miRNATAP -0.243822828282522 0.00994914998543976 NA NA NA hsa-miR-27b-3p E2F7 -0.823491817819754 9.20935302746823e-14 3.06815276582178 3.19808997821633e-30 miRNATAP -0.554743182226216 7.34719457907851e-06 NA NA NA hsa-miR-29c-3p E2F7 -1.4367517608807 1.61767774905781e-21 3.06815276582178 3.19808997821633e-30 miRNATAP -0.853565242395374 3.83219750953783e-24 NA NA NA hsa-miR-181b-5p EAF1 0.488256489401108 0.00105321129419701 -0.37347071039571 1.91389687543601e-05 mirMAP -0.1075909990336 0.000164494107116915 NA NA NA hsa-miR-146a-5p EARS2 -0.742958238440575 0.000765983177482633 0.0207909985366879 0.820518608333665 mirMAP -0.100608104282153 3.71654929099927e-07 NA NA NA hsa-miR-455-5p EBF1 -0.270546034117157 0.0581320703577731 1.93068987874298 7.85878306597582e-25 miRNATAP -0.324654019860579 1.5609622745754e-06 NA NA NA hsa-miR-132-3p EBPL 0.323796239695997 0.00272093067935091 -0.783050405364213 2.79846674895884e-07 miRNAWalker2_validate -0.454556054288175 3.32140898578111e-11 NA NA NA hsa-miR-192-5p ECT2 -0.50188499512787 0.00344713341196035 2.35414440886737 1.90301512891325e-30 miRNAWalker2_validate -0.231432070728605 0.000212033641687837 NA NA NA hsa-miR-215-5p ECT2 -0.981544773246509 3.14452272477156e-05 2.35414440886737 1.90301512891325e-30 miRNAWalker2_validate -0.112743475986521 0.0128904950575959 NA NA NA hsa-miR-15a-5p EDA 0.349521211668244 0.000770735998804736 -0.451949726910863 0.1007806774962 MirTarget;miRNATAP -0.456286097997895 0.000420725134933204 NA NA NA hsa-miR-20a-5p EDA2R 0.854326758727003 5.04256669663285e-07 0.557823623183193 0.0666300815964547 MirTarget -0.349896313309194 4.49449080159799e-05 NA NA NA hsa-miR-432-5p EDA2R -0.536178819038888 0.0748623258271085 0.557823623183193 0.0666300815964547 MirTarget -0.123893278403407 0.0121824521085532 NA NA NA hsa-miR-455-3p EDA2R -1.3998033821095 5.72010709806871e-17 0.557823623183193 0.0666300815964547 PITA -0.198078403498569 0.0205318352806862 NA NA NA hsa-miR-455-5p EDA2R -0.270546034117157 0.0581320703577731 0.557823623183193 0.0666300815964547 miRanda -0.409128809316058 7.97446774935555e-05 NA NA NA hsa-miR-29c-3p EDC3 -1.4367517608807 1.61767774905781e-21 0.728251649618274 7.59128130821528e-26 MirTarget;miRNATAP -0.187677002399767 4.92376302697332e-18 NA NA NA hsa-miR-132-3p EDEM1 0.323796239695997 0.00272093067935091 -0.854125196107966 8.48935244483275e-15 mirMAP -0.323801860904875 1.43695725645568e-10 NA NA NA hsa-miR-19b-3p EDEM1 0.601279551368824 0.00016685097085251 -0.854125196107966 8.48935244483275e-15 mirMAP -0.129971993335108 0.000155945209341094 NA NA NA hsa-miR-20a-5p EDEM1 0.854326758727003 5.04256669663285e-07 -0.854125196107966 8.48935244483275e-15 mirMAP -0.16890991285102 1.07819115404201e-07 NA NA NA hsa-miR-30b-5p EDEM3 -0.54056186708617 2.44688760798341e-05 0.0146542965491152 0.899151321280748 MirTarget -0.106874426144056 0.0144693093727109 NA NA NA hsa-miR-99b-5p EDF1 -0.204769880349524 0.240836989110525 0.0772316020977559 0.514286260415462 miRNAWalker2_validate -0.165002085668706 4.40162662298615e-07 NA NA NA hsa-miR-194-5p EDN1 -0.292530160992458 0.0996141384876663 -0.965661923166048 5.20602087013405e-06 MirTarget;miRNATAP -0.286040426755896 9.1285406895522e-07 NA NA NA hsa-miR-455-5p EDN1 -0.270546034117157 0.0581320703577731 -0.965661923166048 5.20602087013405e-06 MirTarget;PITA;miRanda;miRNATAP -0.247342920007437 0.000723802209900228 NA NA NA hsa-miR-30e-5p EDNRA -0.627815042856657 3.02205690184908e-10 -0.0247461473937958 0.894159315280006 mirMAP -0.197633162598163 0.0278589291377978 NA NA NA hsa-miR-146b-5p EDNRB 0.419719546795449 0.0457375823220155 -1.78299843437792 7.09394782957022e-23 miRanda;miRNATAP -0.139481325175038 0.00163208260580427 NA NA NA hsa-miR-182-5p EDNRB 1.96601340710222 4.39326175603633e-09 -1.78299843437792 7.09394782957022e-23 miRNATAP -0.147320227344145 4.32982154209692e-08 NA NA NA hsa-miR-30e-5p EED -0.627815042856657 3.02205690184908e-10 0.570431696770329 3.87407211322809e-15 MirTarget -0.117228842027613 0.0011437147475047 NA NA NA hsa-miR-192-5p EEF1A2 -0.50188499512787 0.00344713341196035 3.15424331884889 1.24880876453237e-06 miRNAWalker2_validate -0.442810056416726 0.0179285880904937 NA NA NA hsa-miR-99b-5p EEF2 -0.204769880349524 0.240836989110525 -0.146386545397036 0.0860435997374046 miRNAWalker2_validate -0.100916636712588 1.90671460967767e-05 NA NA NA hsa-miR-27b-3p EFNA3 -0.823491817819754 9.20935302746823e-14 1.74857523726189 1.89670377349898e-17 miRNATAP -0.583190806894562 1.14503674353614e-10 NA NA NA hsa-miR-30c-5p EFNA3 -0.432111642767632 0.000159764714931007 1.74857523726189 1.89670377349898e-17 MirTarget;mirMAP;miRNATAP -0.272889750837349 0.00277347446519368 NA NA NA hsa-miR-30e-5p EFNA3 -0.627815042856657 3.02205690184908e-10 1.74857523726189 1.89670377349898e-17 MirTarget;mirMAP -0.485030662588513 2.3026107671749e-06 NA NA NA hsa-miR-19b-3p EFNA5 0.601279551368824 0.00016685097085251 -1.35514027226431 0.000692469246595569 miRNATAP -0.40467492977246 0.00088980599521387 NA NA NA hsa-miR-192-3p EFNB1 -0.6401165114007 0.000266272092403814 -0.0364954474014203 0.756378948827121 mirMAP -0.199454830791294 3.43265014692381e-10 NA NA NA hsa-miR-20a-5p EFNB1 0.854326758727003 5.04256669663285e-07 -0.0364954474014203 0.756378948827121 miRNATAP -0.13113223545145 7.23593446328842e-05 NA NA NA hsa-miR-146b-5p EFNB2 0.419719546795449 0.0457375823220155 0.0997333215214327 0.477026029683948 miRNATAP -0.137244157325279 2.05422274634423e-05 NA NA NA hsa-miR-148a-3p EFNB2 -0.748702855596996 3.93313343865641e-07 0.0997333215214327 0.477026029683948 MirTarget;miRNATAP -0.186304808477715 4.15657096208185e-05 NA NA NA hsa-miR-15a-5p EFNB2 0.349521211668244 0.000770735998804736 0.0997333215214327 0.477026029683948 miRNATAP -0.26917206542744 4.00554467384293e-05 NA NA NA hsa-miR-192-5p EFNB2 -0.50188499512787 0.00344713341196035 0.0997333215214327 0.477026029683948 miRNAWalker2_validate;miRNATAP -0.167969783572693 2.02210945072605e-05 NA NA NA hsa-miR-19b-3p EFNB2 0.601279551368824 0.00016685097085251 0.0997333215214327 0.477026029683948 miRNATAP -0.15123641557929 0.000356936872648333 NA NA NA hsa-miR-34a-5p EFNB3 1.03694231790865 5.74864019540594e-14 -2.97294174553494 1.00790111127231e-28 miRNATAP -0.5799596750042 2.1667163018711e-09 NA NA NA hsa-miR-19b-3p EFR3A 0.601279551368824 0.00016685097085251 -0.119153209175691 0.320887144206676 MirTarget -0.27100197299928 1.52488908229176e-14 NA NA NA hsa-miR-30c-5p EFR3A -0.432111642767632 0.000159764714931007 -0.119153209175691 0.320887144206676 mirMAP;miRNATAP -0.120881907435238 0.0178857743455836 NA NA NA hsa-miR-146b-5p EFR3B 0.419719546795449 0.0457375823220155 0.419893657122922 0.00614160314164536 miRanda -0.102081200244341 0.00411411895824305 NA NA NA hsa-miR-192-5p EFR3B -0.50188499512787 0.00344713341196035 0.419893657122922 0.00614160314164536 mirMAP -0.267653467596125 3.69126874444107e-10 NA NA NA hsa-miR-146b-5p EFS 0.419719546795449 0.0457375823220155 -1.11774497222674 1.32917915137612e-05 miRanda -0.175056848201661 0.00355128038200037 NA NA NA hsa-miR-146a-5p EGFR -0.742958238440575 0.000765983177482633 -1.01672920195188 6.69873186671412e-07 miRNAWalker2_validate -0.224421920698198 6.22524592924969e-07 24895573;25242818;22161865;25596948;25417703;23555954;24839931;21632853 Furthermore western blot showed that miR-146a mimic downregulated EGFR ERK1/2 and stat5 signalings; These effects were less potent compared to that of a siRNA targeting EGFR a known target gene of miR-146a; Moreover miR-146a mimic could enhance the cell growth inhibition and apoptosis induction impact of various EGFR targeting agents;Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;MiR 146a suppresses tumor growth and progression by targeting EGFR pathway and in a p ERK dependent manner in castration resistant prostate cancer; Mechanistic studies revealed that miR-146a repressed the expression of EGFR through binding to its 3'-untranslated region; Our findings suggest that ubiquitous loss of miR-146a is a critical mechanism for overexpression of EGFR in CRPC which is crucial to better understanding the pathogenesis of CRPC;Furthermore the expressions of bax and cleaved-caspase-3 mainly were increased in control and overexpression miR-146a groups however the expression of EGFR was inverse; All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells which was performed by up-regulating miR-146a expression then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways and inhibiting invasion through down-regulating the expression of EGFR;Here we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a; We show that BRCA1 binds to MIR146A promoter and activates transcription which in turn attenuates EGFR expression;In functional experiments miR-146a suppressed cell growth induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines H358 H1650 H1975 HCC827 and H292 miR-146a also inhibited the migratory capacity of these NSCLC cells; On the other hand miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR including both TKIs gefitinib erlotinib and afatinib and a monoclonal antibody cetuximab; Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling;Deregulation of miR 146a expression in a mouse model of pancreatic cancer affecting EGFR signaling; Treatment of PC cells with CDF a novel synthetic compound led to re-expression of miR-146a resulting in the down-regulation of EGFR expression; Further knock-down of miR-146a in AsPC-1 cells led to the up-regulation of EGFR expression and showed increased clonogenic growth; In addition knock-down of EGFR by EGFR siRNA transfection of parental AsPC-1 cells and AsPC-1 cells stably transfected with pre-miR-146a resulted in decreased invasive capacity which was further confirmed by reduced luciferase activity in cells transfected with pMIR-Luc reporter vector containing miR-146a binding site; Collectively these results suggest that the loss of expression of miR-146a is a fundamental mechanism for over-expression of EGFR signaling and that re-expression of miR-146a by CDF treatment could be useful in designing personalized strategy for the treatment of human PC;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;;progression;;;;; liver cancer;pancreatic cancer;prostate cancer;breast cancer;breast cancer;lung squamous cell cancer;pancreatic cancer;gastric cancer hsa-miR-146b-5p EGFR 0.419719546795449 0.0457375823220155 -1.01672920195188 6.69873186671412e-07 miRNATAP -0.221138858293073 3.44879306513365e-06 NA NA NA hsa-miR-21-5p EGFR 1.51084295924322 1.54551622173259e-34 -1.01672920195188 6.69873186671412e-07 miRNAWalker2_validate;miRTarBase -0.440371363258275 3.21604130567409e-09 24198203;20113523;24012640;24331411;26563758;19597153;26026961;20048743 In radically resected NSCLC patients the expression levels of miR-21 10b in patients with EGFR mutation were much higher than those without mutation;Thus the miR-21 inhibitor might interrupt the activity of EGFR pathways independently of PTEN status;Further the expression of miR-21 is regulated by EGFR via the activation of β-catenin and AP-1; These data indicate that a feedback loop exists between miR-21 and EGFR; These results clarify a novel association between miR-21 and EGFR in the regulation of cancer cell progression;MiR 21 overexpression is associated with acquired resistance of EGFR TKI in non small cell lung cancer;Higher expression levels of miR-21 AmiR-27a and miR-218 detected in this study suggest potential roles of these miRNAs in primary resistance to EGFR-TKI in advanced NSCLC patients with EGFR exon 19 deletion mutations;MiR 21 is an EGFR regulated anti apoptotic factor in lung cancer in never smokers; The changes in expression of some of these miRNAs including miR-21 were more remarkable in cases with EGFR mutations than in those without these mutations; In the never-smoker-derived lung adenocarcinoma cell line H3255 with mutant EGFR and high levels of p-EGFR and miR-21 antisense inhibition of miR-21 enhanced AG1478-induced apoptosis; In a never-smoker-derived adenocarcinoma cell line H441 with wild-type EGFR the antisense miR-21 not only showed the additive effect with AG1478 but also induced apoptosis by itself; These results suggest that aberrantly increased expression of miR-21 which is enhanced further by the activated EGFR signaling pathway plays a significant role in lung carcinogenesis in never-smokers as well as in smokers and is a potential therapeutic target in both EGFR-mutant and wild-type cases;Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR mutated lung cancer via nickel induced microRNA 21 expression;Downregulation of miR 21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status ;;progression;drug resistance;staging;drug resistance;tumorigenesis;; lung squamous cell cancer;glioblastoma;glioblastoma;lung squamous cell cancer;lung squamous cell cancer;lung cancer;lung cancer;glioblastoma hsa-miR-455-5p EGFR -0.270546034117157 0.0581320703577731 -1.01672920195188 6.69873186671412e-07 miRanda -0.226922724788645 0.00135818927133814 NA NA NA hsa-miR-15a-5p EGLN1 0.349521211668244 0.000770735998804736 0.0756107370151957 0.405502512247036 MirTarget -0.199232552642064 2.38498365947827e-06 NA NA NA hsa-miR-194-5p EGR2 -0.292530160992458 0.0996141384876663 -2.92720452155501 5.23330307324282e-27 miRNATAP -0.449792912344151 1.07031361411781e-08 NA NA NA hsa-miR-20a-5p EGR2 0.854326758727003 5.04256669663285e-07 -2.92720452155501 5.23330307324282e-27 MirTarget;miRNATAP -0.392517470696261 1.49319772446471e-06 23924943 Involvement of miR 20a in promoting gastric cancer progression by targeting early growth response 2 EGR2; Luciferase activity and Western blot confirmed that miR-20a negatively regulated EGR2 expression; Overexpression of EGR2 significantly attenuated the oncogenic effect of miR-20a miR-20a was involved in the carcinogenesis of GC through modulation of the EGR2 signaling pathway progression;drug resistance;tumorigenesis gastric cancer hsa-miR-148a-3p EGR3 -0.748702855596996 3.93313343865641e-07 -2.49025618015861 9.70314095894188e-25 MirTarget -0.209189146874948 0.0129875229995118 NA NA NA hsa-miR-409-3p EHBP1 -0.499649792570937 0.0526751181520117 -0.729939271070903 1.55759368035134e-10 PITA -0.100997191004728 3.55624209829509e-06 NA NA NA hsa-miR-192-5p EHBP1L1 -0.50188499512787 0.00344713341196035 0.331486249355696 0.00123833313803043 miRNAWalker2_validate -0.149522454377421 2.10263925524772e-07 NA NA NA hsa-miR-455-5p EHD2 -0.270546034117157 0.0581320703577731 0.509834796600586 0.000749157758690256 miRanda -0.215289239418544 3.12518858013755e-05 NA NA NA hsa-miR-146b-5p EHD3 0.419719546795449 0.0457375823220155 -2.40191462006911 4.07784594091942e-34 miRanda -0.111474315239213 0.0252309111444328 NA NA NA hsa-miR-17-3p EHD3 0.410352776142368 0.00422200500748636 -2.40191462006911 4.07784594091942e-34 MirTarget -0.207963510485688 0.00433878914996452 NA NA NA hsa-miR-27b-3p EHMT2 -0.823491817819754 9.20935302746823e-14 1.30916131333971 6.434117976644e-33 miRNAWalker2_validate -0.244496105915327 1.35799566097197e-06 NA NA NA hsa-miR-455-5p EID3 -0.270546034117157 0.0581320703577731 -0.038842657067151 0.82314695261914 miRanda -0.24357543023113 3.70107227782998e-05 NA NA NA hsa-miR-21-5p EIF1AX 1.51084295924322 1.54551622173259e-34 -0.291968132466788 0.00113929910702412 miRNATAP -0.23005485673981 5.66462566420026e-13 NA NA NA hsa-miR-19b-3p EIF2AK2 0.601279551368824 0.00016685097085251 -0.0743296928421406 0.469391726504632 mirMAP -0.120341565527709 0.000100301468240269 NA NA NA hsa-miR-27b-3p EIF2AK2 -0.823491817819754 9.20935302746823e-14 -0.0743296928421406 0.469391726504632 mirMAP -0.151761569808996 0.000556375195833077 NA NA NA hsa-miR-30b-5p EIF2AK2 -0.54056186708617 2.44688760798341e-05 -0.0743296928421406 0.469391726504632 mirMAP -0.102713968054953 0.00809981634767649 NA NA NA hsa-miR-30c-5p EIF2S1 -0.432111642767632 0.000159764714931007 -0.153544948774539 0.0218786983450725 mirMAP -0.112789772778846 6.40898253266323e-05 NA NA NA hsa-miR-27b-3p EIF2S2 -0.823491817819754 9.20935302746823e-14 0.317957817884656 2.49059742366842e-05 miRNATAP -0.115910394349106 0.00036114562038191 NA NA NA hsa-miR-29c-3p EIF2S2 -1.4367517608807 1.61767774905781e-21 0.317957817884656 2.49059742366842e-05 miRNATAP -0.162061887252421 9.21645953801183e-13 NA NA NA hsa-miR-132-3p EIF4A2 0.323796239695997 0.00272093067935091 0.0307503733646621 0.737001132372133 miRNATAP -0.167436736592274 4.57633826092439e-05 NA NA NA hsa-miR-194-5p EIF4E3 -0.292530160992458 0.0996141384876663 -1.65776517548242 5.25920384886669e-14 miRNATAP -0.275040162221109 9.21362307260286e-06 NA NA NA hsa-miR-221-3p EIF4E3 1.12244756358612 3.48370308238012e-13 -1.65776517548242 5.25920384886669e-14 miRNATAP -0.356271018925111 2.54218264646758e-07 NA NA NA hsa-miR-222-3p EIF4E3 1.08574156066353 1.76407192348131e-11 -1.65776517548242 5.25920384886669e-14 miRNATAP -0.158494639702832 0.0182707207722329 NA NA NA hsa-miR-21-5p EIF4EBP2 1.51084295924322 1.54551622173259e-34 -0.113333423080928 0.274925870028417 miRNAWalker2_validate -0.25252138439241 7.37948303219334e-12 NA NA NA hsa-miR-21-5p EIF5 1.51084295924322 1.54551622173259e-34 -0.718800486296156 2.12840695796032e-16 miRNAWalker2_validate -0.256656216236592 9.41542312025708e-16 NA NA NA hsa-miR-30e-5p EIF5A2 -0.627815042856657 3.02205690184908e-10 0.50245173358611 0.0807610460010779 mirMAP -0.653576022288779 2.13910315436168e-06 NA NA NA hsa-miR-21-5p ELF2 1.51084295924322 1.54551622173259e-34 -0.389705823694809 5.48578362990734e-07 MirTarget;miRNATAP -0.166817795102023 3.10695031389035e-09 NA NA NA hsa-miR-148a-3p ELFN2 -0.748702855596996 3.93313343865641e-07 2.86706730299717 2.25493376503085e-09 mirMAP -0.483208813462652 0.00248298597422395 NA NA NA hsa-miR-19b-3p ELK3 0.601279551368824 0.00016685097085251 -0.374593711821051 0.0677288387929772 MirTarget;miRNATAP -0.198024706304583 0.00145423922294138 NA NA NA hsa-miR-20a-5p ELK3 0.854326758727003 5.04256669663285e-07 -0.374593711821051 0.0677288387929772 MirTarget;miRNATAP -0.260010389374476 6.49942666577106e-06 NA NA NA hsa-miR-19b-3p ELK4 0.601279551368824 0.00016685097085251 0.23519596686873 0.0267189511596387 mirMAP -0.150861509627552 2.28615934127865e-06 NA NA NA hsa-miR-20a-5p ELK4 0.854326758727003 5.04256669663285e-07 0.23519596686873 0.0267189511596387 miRNATAP -0.130494503212055 1.21344676733769e-05 NA NA NA hsa-miR-30b-5p ELK4 -0.54056186708617 2.44688760798341e-05 0.23519596686873 0.0267189511596387 mirMAP -0.126803765220563 0.0015757498127986 NA NA NA hsa-miR-182-5p ELL2 1.96601340710222 4.39326175603633e-09 -0.765981836031949 3.63519932659754e-07 MirTarget;miRNATAP -0.147936363447877 3.08014915785526e-12 NA NA NA hsa-miR-19b-3p ELMOD2 0.601279551368824 0.00016685097085251 -0.0311749578700296 0.70879596560202 MirTarget;miRNATAP -0.149384512893344 1.62751204057106e-09 NA NA NA hsa-miR-192-5p ELOVL1 -0.50188499512787 0.00344713341196035 0.772132123121458 7.40013744177412e-22 miRNAWalker2_validate -0.130972869698946 2.74902140074231e-08 NA NA NA hsa-miR-455-3p ELOVL1 -1.3998033821095 5.72010709806871e-17 0.772132123121458 7.40013744177412e-22 miRNAWalker2_validate -0.125322435850412 8.10415245680592e-08 NA NA NA hsa-miR-29c-3p ELOVL4 -1.4367517608807 1.61767774905781e-21 0.351738066991718 0.180683584274715 miRNATAP -0.305747450662569 0.000145783678087711 NA NA NA hsa-miR-19b-3p ELOVL5 0.601279551368824 0.00016685097085251 0.0625432125684764 0.603208257430648 miRNAWalker2_validate;MirTarget;miRNATAP -0.135682867491536 0.000184574135198369 NA NA NA hsa-miR-181a-5p ELOVL6 0.250113435902954 0.0551933249319293 -1.01433709478282 1.15410707798086e-06 mirMAP -0.373874883155177 1.92518751531998e-06 NA NA NA hsa-miR-181b-5p ELOVL6 0.488256489401108 0.00105321129419701 -1.01433709478282 1.15410707798086e-06 mirMAP -0.412266139684575 1.14967553910155e-09 NA NA NA hsa-miR-30e-5p ELOVL7 -0.627815042856657 3.02205690184908e-10 -0.108433535124748 0.800367929821267 mirMAP -0.541008054552371 0.00899796716358509 NA NA NA hsa-miR-192-5p EMB -0.50188499512787 0.00344713341196035 -0.51114171042416 0.0227127805618997 miRNAWalker2_validate -0.465964670702723 4.98075890858267e-14 NA NA NA hsa-miR-30e-5p EMB -0.627815042856657 3.02205690184908e-10 -0.51114171042416 0.0227127805618997 MirTarget -0.218022227507836 0.0451246463296037 NA NA NA hsa-miR-455-5p EMB -0.270546034117157 0.0581320703577731 -0.51114171042416 0.0227127805618997 miRanda -0.382831912371009 4.91928453411449e-07 NA NA NA hsa-miR-215-5p EME1 -0.981544773246509 3.14452272477156e-05 3.02905521254264 1.10248206102695e-42 miRNAWalker2_validate -0.166133311656346 0.000950991758476558 NA NA NA hsa-miR-192-5p EML1 -0.50188499512787 0.00344713341196035 -0.62886462630818 0.000194859905761294 miRNAWalker2_validate -0.225326163106881 2.33447679051203e-06 NA NA NA hsa-miR-455-5p EML1 -0.270546034117157 0.0581320703577731 -0.62886462630818 0.000194859905761294 miRanda -0.182203423836797 0.00170137496627611 NA NA NA hsa-miR-29c-3p EML4 -1.4367517608807 1.61767774905781e-21 0.0557983745651924 0.517942698387788 MirTarget;miRNATAP -0.138066022182405 1.20878835618361e-07 NA NA NA hsa-miR-29c-3p EML6 -1.4367517608807 1.61767774905781e-21 1.72004100743374 8.69237572626887e-13 miRNATAP -0.351319460524647 3.31979917349392e-06 NA NA NA hsa-miR-34a-5p EMP1 1.03694231790865 5.74864019540594e-14 -0.626120147682813 0.00206873304567627 miRNAWalker2_validate -0.169774300557831 0.0155225133149708 NA NA NA hsa-miR-181b-5p EMP2 0.488256489401108 0.00105321129419701 -0.2961927570137 0.0244099527389396 mirMAP -0.296298361509613 1.51240889807068e-12 NA NA NA hsa-miR-146b-5p EMX1 0.419719546795449 0.0457375823220155 2.21293111250738 1.63197126982681e-07 miRanda -0.299244063354977 0.00259705686862454 NA NA NA hsa-miR-27b-3p EN2 -0.823491817819754 9.20935302746823e-14 0.979515878391363 0.00653397638746686 MirTarget;miRNATAP -0.386228831891449 0.0131678915762146 NA NA NA hsa-miR-30e-5p EN2 -0.627815042856657 3.02205690184908e-10 0.979515878391363 0.00653397638746686 mirMAP -0.476588009761905 0.0063519957997576 NA NA NA hsa-miR-194-5p ENAH -0.292530160992458 0.0996141384876663 1.39629433723863 3.42757488063496e-20 mirMAP;miRNATAP -0.215056024206748 6.5926629049463e-07 NA NA NA hsa-miR-27b-3p ENAH -0.823491817819754 9.20935302746823e-14 1.39629433723863 3.42757488063496e-20 miRNATAP -0.376842331240528 2.44055180499439e-08 NA NA NA hsa-miR-192-5p ENC1 -0.50188499512787 0.00344713341196035 -1.087792569799 1.5617178371754e-09 miRNAWalker2_validate -0.165619390590527 0.00144767299135608 NA NA NA hsa-miR-19b-3p ENC1 0.601279551368824 0.00016685097085251 -1.087792569799 1.5617178371754e-09 MirTarget -0.149833197404179 0.00726784503774335 NA NA NA hsa-miR-215-5p ENC1 -0.981544773246509 3.14452272477156e-05 -1.087792569799 1.5617178371754e-09 miRNAWalker2_validate -0.142176335611224 0.000147940755342304 NA NA NA hsa-miR-192-5p ENDOD1 -0.50188499512787 0.00344713341196035 -0.998600185815336 9.70620010845927e-08 miRNAWalker2_validate -0.463066599557689 2.93930391048484e-19 NA NA NA hsa-miR-19b-3p ENDOD1 0.601279551368824 0.00016685097085251 -0.998600185815336 9.70620010845927e-08 mirMAP -0.342674812633697 1.56455489467667e-09 NA NA NA hsa-miR-224-3p ENDOD1 1.40770116795301 1.31426607144612e-08 -0.998600185815336 9.70620010845927e-08 mirMAP -0.101105612989004 0.00660341538433555 NA NA NA hsa-miR-29c-3p ENHO -1.4367517608807 1.61767774905781e-21 -0.587190384379513 0.0995530535914025 MirTarget;miRNATAP -0.259368618818062 0.0182640881712638 NA NA NA hsa-miR-30b-5p ENPP1 -0.54056186708617 2.44688760798341e-05 -1.11112717299379 2.16026245265541e-12 mirMAP -0.149941040986459 0.0150103202936068 NA NA NA hsa-miR-148a-3p ENTPD1 -0.748702855596996 3.93313343865641e-07 0.548264152440102 1.02295823309827e-09 mirMAP -0.300291742240826 8.25145845724624e-27 NA NA NA hsa-miR-192-3p ENTPD1 -0.6401165114007 0.000266272092403814 0.548264152440102 1.02295823309827e-09 mirMAP -0.223417933356223 1.73608057360225e-20 NA NA NA hsa-miR-30c-5p ENTPD1 -0.432111642767632 0.000159764714931007 0.548264152440102 1.02295823309827e-09 mirMAP -0.100074116025338 0.0101350795382755 NA NA NA hsa-miR-30e-5p ENTPD1 -0.627815042856657 3.02205690184908e-10 0.548264152440102 1.02295823309827e-09 mirMAP -0.218274186405979 5.79675456269329e-07 NA NA NA hsa-miR-455-3p ENTPD1 -1.3998033821095 5.72010709806871e-17 0.548264152440102 1.02295823309827e-09 mirMAP -0.212664443281066 5.84051894427302e-18 NA NA NA hsa-miR-192-5p ENTPD3 -0.50188499512787 0.00344713341196035 0.296163404386955 0.380560088941134 miRNAWalker2_validate -0.515033294773545 4.8899737507346e-08 NA NA NA hsa-miR-21-5p ENTPD4 1.51084295924322 1.54551622173259e-34 -0.411856151063958 0.000793591455053331 mirMAP -0.139222165419153 0.00192356522289834 NA NA NA hsa-miR-182-5p ENTPD5 1.96601340710222 4.39326175603633e-09 -1.12067424960293 7.40905747722605e-09 MirTarget -0.108849012400236 0.000101219605798385 25115394 The inverse relation between miR-182 and the expression of its target gene ENTPD5 was investigated by immunohistochemical analysis; Our results strengthen the hypothesis of a central role of miR-182 dysregulation in colon mucosa transformation demonstrate the concomitant progressive down-regulation of ENTPD5 levels during colon carcinogenesis and indicate the potential of circulating miR-182 as blood based biomarker for screening and monitoring CRC during the follow-up progression;tumorigenesis colorectal cancer hsa-miR-15a-5p ENTPD7 0.349521211668244 0.000770735998804736 -0.302510047544772 0.0170788864380501 MirTarget -0.131680239205157 0.0278119742958132 NA NA NA hsa-miR-20a-5p EPAS1 0.854326758727003 5.04256669663285e-07 -0.884989955981347 7.97509276269862e-17 miRNATAP -0.132064017426939 2.07565893687308e-05 NA NA NA hsa-miR-30b-5p EPB41 -0.54056186708617 2.44688760798341e-05 0.00964115585676772 0.926635447208956 MirTarget -0.123578072728132 0.00173770035674178 NA NA NA hsa-miR-148a-3p EPB41L1 -0.748702855596996 3.93313343865641e-07 0.134154503301847 0.605658196491617 MirTarget -0.302843609687242 0.000339392792749624 NA NA NA hsa-miR-15a-5p EPB41L1 0.349521211668244 0.000770735998804736 0.134154503301847 0.605658196491617 MirTarget -0.308422197285012 0.0116973345918035 NA NA NA hsa-miR-34a-5p EPB41L2 1.03694231790865 5.74864019540594e-14 -0.156032263885083 0.261569667549103 miRNAWalker2_validate -0.165040221175775 0.000512496349250972 NA NA NA hsa-miR-181a-5p EPB41L4B 0.250113435902954 0.0551933249319293 -1.96928704307134 1.79757456187987e-18 miRNATAP -0.283461804548773 0.00125735669614572 NA NA NA hsa-miR-181b-5p EPB41L4B 0.488256489401108 0.00105321129419701 -1.96928704307134 1.79757456187987e-18 miRNATAP -0.360462374881105 2.03779917294123e-06 NA NA NA hsa-miR-182-5p EPB41L4B 1.96601340710222 4.39326175603633e-09 -1.96928704307134 1.79757456187987e-18 miRNATAP -0.201539462073586 8.37857037246094e-10 NA NA NA hsa-miR-192-5p EPDR1 -0.50188499512787 0.00344713341196035 0.218631967122443 0.25962335180911 miRNAWalker2_validate -0.255870434514823 2.60146198251815e-06 NA NA NA hsa-miR-215-5p EPDR1 -0.981544773246509 3.14452272477156e-05 0.218631967122443 0.25962335180911 miRNAWalker2_validate -0.147206222542909 0.000195441207874723 NA NA NA hsa-miR-30e-5p EPDR1 -0.627815042856657 3.02205690184908e-10 0.218631967122443 0.25962335180911 MirTarget -0.404561631273005 1.35886035499285e-05 NA NA NA hsa-miR-455-5p EPDR1 -0.270546034117157 0.0581320703577731 0.218631967122443 0.25962335180911 PITA;miRanda -0.274345387194358 3.17726521379134e-05 NA NA NA hsa-miR-99a-5p EPDR1 -1.51481656384839 3.93230057259529e-14 0.218631967122443 0.25962335180911 MirTarget;miRNATAP -0.178755567148637 8.37867685916654e-05 NA NA NA hsa-miR-29c-3p EPHA10 -1.4367517608807 1.61767774905781e-21 1.45302267765796 0.000731318496582353 miRNATAP -0.336559031703226 0.0115381216281526 NA NA NA hsa-miR-34a-5p EPHA2 1.03694231790865 5.74864019540594e-14 -2.12469060332663 2.01316632998596e-28 miRNAWalker2_validate -0.219033843498792 0.00193427032704837 NA NA NA hsa-miR-194-5p EPHA3 -0.292530160992458 0.0996141384876663 -1.75532340990487 1.13157153732929e-08 miRNATAP -0.446486866064484 1.48020863862061e-07 NA NA NA hsa-miR-455-5p EPHA3 -0.270546034117157 0.0581320703577731 -1.75532340990487 1.13157153732929e-08 miRanda -0.38073447168385 0.000366081259258422 NA NA NA hsa-miR-20a-5p EPHA4 0.854326758727003 5.04256669663285e-07 -0.0136675398232678 0.946218625851897 miRNATAP -0.211339657032399 0.000213656396565315 NA NA NA hsa-miR-34a-5p EPHA4 1.03694231790865 5.74864019540594e-14 -0.0136675398232678 0.946218625851897 miRNATAP -0.15835170568816 0.0228198024220174 NA NA NA hsa-miR-182-5p EPM2A 1.96601340710222 4.39326175603633e-09 -1.15770706080728 3.57362529045184e-22 miRNATAP -0.116013550404543 3.95599422692745e-11 NA NA NA hsa-miR-21-5p EPM2A 1.51084295924322 1.54551622173259e-34 -1.15770706080728 3.57362529045184e-22 miRNAWalker2_validate -0.563090697791134 5.72879488783456e-42 NA NA NA hsa-miR-132-3p EPM2AIP1 0.323796239695997 0.00272093067935091 -0.295909832927366 0.00243576222358727 MirTarget -0.315939834121061 2.28880895219992e-13 NA NA NA hsa-miR-21-5p EPM2AIP1 1.51084295924322 1.54551622173259e-34 -0.295909832927366 0.00243576222358727 mirMAP -0.279763209592185 4.45838175922043e-16 NA NA NA hsa-miR-148a-3p EPN2 -0.748702855596996 3.93313343865641e-07 0.0353361937087526 0.693340512927564 MirTarget;miRNATAP -0.116478658095663 5.79350548452928e-05 NA NA NA hsa-miR-181a-5p EPS15 0.250113435902954 0.0551933249319293 -0.299266773136494 8.77908615019208e-06 miRNATAP -0.114999885575644 4.73880701116304e-06 NA NA NA hsa-miR-181b-5p EPS15 0.488256489401108 0.00105321129419701 -0.299266773136494 8.77908615019208e-06 miRNATAP -0.126453539543329 5.55974457882669e-09 NA NA NA hsa-miR-19b-3p EPS15 0.601279551368824 0.00016685097085251 -0.299266773136494 8.77908615019208e-06 MirTarget;miRNATAP -0.14456127220433 4.47361926987748e-13 NA NA NA hsa-miR-20a-5p ERAP1 0.854326758727003 5.04256669663285e-07 -0.0558751979920373 0.664128805537484 MirTarget -0.159909130653423 9.33581675488412e-06 NA NA NA hsa-miR-34a-5p ERC1 1.03694231790865 5.74864019540594e-14 -0.21801324351835 0.0127296421455448 mirMAP;miRNATAP -0.100724628522124 0.000763292822219872 NA NA NA hsa-miR-148a-3p ERC2 -0.748702855596996 3.93313343865641e-07 1.31841593023186 2.0512747793649e-05 MirTarget -0.310718760201474 0.00231511105017742 NA NA NA hsa-miR-455-5p ERC2 -0.270546034117157 0.0581320703577731 1.31841593023186 2.0512747793649e-05 MirTarget;miRanda;miRNATAP -0.262427659082247 0.014267521495516 NA NA NA hsa-miR-19b-3p ERCC4 0.601279551368824 0.00016685097085251 -0.398490625556519 0.000316330847829454 MirTarget -0.182333167667438 4.31223712699318e-08 NA NA NA hsa-miR-221-3p ERCC4 1.12244756358612 3.48370308238012e-13 -0.398490625556519 0.000316330847829454 MirTarget -0.235928816218724 1.36429369950774e-12 NA NA NA hsa-miR-222-3p ERCC4 1.08574156066353 1.76407192348131e-11 -0.398490625556519 0.000316330847829454 MirTarget -0.225252640075628 1.78776833513893e-12 NA NA NA hsa-miR-30b-5p ERCC4 -0.54056186708617 2.44688760798341e-05 -0.398490625556519 0.000316330847829454 MirTarget;mirMAP -0.137548838857277 0.00106120001533528 NA NA NA hsa-miR-15a-5p ERCC6 0.349521211668244 0.000770735998804736 -0.296790596393036 0.00192692286682122 MirTarget -0.108970770555028 0.0158274096220848 NA NA NA hsa-miR-192-5p ERCC6L -0.50188499512787 0.00344713341196035 2.80133333720022 1.52716959352411e-34 miRNAWalker2_validate -0.143546239673975 0.0423567403392569 NA NA NA hsa-miR-215-5p ERCC6L -0.981544773246509 3.14452272477156e-05 2.80133333720022 1.52716959352411e-34 miRNAWalker2_validate -0.145153212823859 0.00439425401673053 NA NA NA hsa-miR-146b-5p ERG 0.419719546795449 0.0457375823220155 -0.946364162149151 2.89201137044475e-11 miRanda -0.111628522225852 0.000922996561632499 NA NA NA hsa-miR-34a-5p ERLIN1 1.03694231790865 5.74864019540594e-14 -1.4133557265875 4.37725865760753e-30 miRNAWalker2_validate -0.162127143182714 0.00038442697071653 NA NA NA hsa-miR-146b-5p ERLIN2 0.419719546795449 0.0457375823220155 -0.765814822219247 2.25238859952501e-10 miRanda -0.108743801940182 0.000131834110641602 NA NA NA hsa-miR-181a-5p ERLIN2 0.250113435902954 0.0551933249319293 -0.765814822219247 2.25238859952501e-10 MirTarget -0.209436929117961 4.99453028917944e-06 NA NA NA hsa-miR-181b-5p ERLIN2 0.488256489401108 0.00105321129419701 -0.765814822219247 2.25238859952501e-10 MirTarget -0.181481990891556 5.44161625142249e-06 NA NA NA hsa-miR-148a-3p ERMP1 -0.748702855596996 3.93313343865641e-07 0.542622265078398 5.31729874404597e-06 MirTarget -0.255518323160464 3.01191040047704e-11 NA NA NA hsa-miR-192-5p ERMP1 -0.50188499512787 0.00344713341196035 0.542622265078398 5.31729874404597e-06 miRNAWalker2_validate -0.122926009117854 0.00029724995055624 NA NA NA hsa-miR-409-3p ESM1 -0.499649792570937 0.0526751181520117 4.20711739039803 3.17446765555696e-44 MirTarget -0.231101569868066 0.000263268434347144 NA NA NA hsa-miR-132-3p ESR1 0.323796239695997 0.00272093067935091 -4.11885094897542 1.63160126578307e-28 mirMAP -0.976422932593229 4.49956617170777e-08 NA NA NA hsa-miR-181a-5p ESR1 0.250113435902954 0.0551933249319293 -4.11885094897542 1.63160126578307e-28 miRNATAP -0.764905967462692 2.36823796277528e-07 NA NA NA hsa-miR-181b-5p ESR1 0.488256489401108 0.00105321129419701 -4.11885094897542 1.63160126578307e-28 miRNATAP -0.93245685386221 1.82901466028359e-13 NA NA NA hsa-miR-19b-3p ESR1 0.601279551368824 0.00016685097085251 -4.11885094897542 1.63160126578307e-28 miRNAWalker2_validate;miRTarBase;miRNATAP -0.87866460920166 8.60632923405163e-14 NA NA NA hsa-miR-20b-5p ESR1 0.457668023910379 0.0285865211936156 -4.11885094897542 1.63160126578307e-28 miRNAWalker2_validate;miRTarBase -0.300958505167502 0.00117158475746545 NA NA NA hsa-miR-221-3p ESR1 1.12244756358612 3.48370308238012e-13 -4.11885094897542 1.63160126578307e-28 miRNAWalker2_validate;miRNATAP -1.10370333584046 3.63055649331572e-21 25483016 HBx protein induced upregulation of microRNA 221 promotes aberrant proliferation in HBV‑related hepatocellular carcinoma by targeting estrogen receptor α liver cancer hsa-miR-222-3p ESR1 1.08574156066353 1.76407192348131e-11 -4.11885094897542 1.63160126578307e-28 miRNAWalker2_validate;miRNATAP -1.11367453777358 1.66419995127483e-23 NA NA NA hsa-miR-409-3p ESR1 -0.499649792570937 0.0526751181520117 -4.11885094897542 1.63160126578307e-28 mirMAP -0.207334729762513 0.00587853256444165 NA NA NA hsa-miR-182-5p ESRRG 1.96601340710222 4.39326175603633e-09 -2.51599370184769 6.04312161539017e-10 mirMAP;miRNATAP -0.139582144853157 0.018515471363933 NA NA NA hsa-miR-455-5p ESRRG -0.270546034117157 0.0581320703577731 -2.51599370184769 6.04312161539017e-10 PITA;miRanda -0.385052464044038 0.00678647598725881 NA NA NA hsa-miR-20a-5p ESYT2 0.854326758727003 5.04256669663285e-07 -0.172147082999767 0.039027418424603 mirMAP -0.141888770769474 8.4393527551558e-10 NA NA NA hsa-miR-21-5p ESYT2 1.51084295924322 1.54551622173259e-34 -0.172147082999767 0.039027418424603 miRNAWalker2_validate;MirTarget -0.121583148574807 5.55345929002504e-05 NA NA NA hsa-miR-15a-5p ETNK1 0.349521211668244 0.000770735998804736 -0.276315368433913 0.00161606201585604 MirTarget -0.104561286853395 0.0113852397712741 NA NA NA hsa-miR-132-3p ETNK2 0.323796239695997 0.00272093067935091 -1.42301778283554 7.52967048096134e-07 miRNAWalker2_validate -0.92139097765097 8.39191343214563e-13 NA NA NA hsa-miR-221-3p ETS1 1.12244756358612 3.48370308238012e-13 -0.888146453921594 7.30600721510989e-10 miRTarBase;miRNATAP -0.163620716574743 0.000282330030340872 21711453 To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions melanoma hsa-miR-222-3p ETS1 1.08574156066353 1.76407192348131e-11 -0.888146453921594 7.30600721510989e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.114027687122358 0.00860678284178252 21711453 Constitutive activation of the ETS 1 miR 222 circuitry in metastatic melanoma; We demonstrate that the proto-oncogene ETS-1 involved in the pathogenesis of cancers of different origin is a transcriptional regulator of miR-222 by direct binding to its promoter region; Differently from 293FT cells or early stage melanomas where unphosphorylated ETS-1 represses miR-222 transcription in metastatic melanoma the constitutively Thr-38 phosphorylated fraction of ETS-1 induces miR-222; To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions staging melanoma hsa-miR-455-5p ETS1 -0.270546034117157 0.0581320703577731 -0.888146453921594 7.30600721510989e-10 MirTarget;PITA;miRanda;miRNATAP -0.234313961624189 2.69025876931775e-06 NA NA NA hsa-miR-221-3p ETS2 1.12244756358612 3.48370308238012e-13 -1.75880257972087 1.4083094059301e-32 miRNATAP -0.357161643234593 8.61994145380732e-14 NA NA NA hsa-miR-222-3p ETS2 1.08574156066353 1.76407192348131e-11 -1.75880257972087 1.4083094059301e-32 miRNATAP -0.317374648542082 6.19864720553015e-12 NA NA NA hsa-miR-19b-3p ETV1 0.601279551368824 0.00016685097085251 -0.467778656758692 0.0521717741982034 MirTarget;miRNATAP -0.210501555125072 0.00402886697891088 NA NA NA hsa-miR-20a-5p ETV1 0.854326758727003 5.04256669663285e-07 -0.467778656758692 0.0521717741982034 MirTarget;miRNATAP -0.240188015746806 0.000419927774962963 NA NA NA hsa-miR-146b-5p ETV3 0.419719546795449 0.0457375823220155 -0.413342953759138 0.0915197652904334 miRanda -0.145199103761469 0.0106131856478993 NA NA NA hsa-miR-29c-3p ETV4 -1.4367517608807 1.61767774905781e-21 1.7822026212355 2.76801788603885e-05 miRNATAP -0.519316646256947 7.78016905648978e-05 NA NA NA hsa-miR-148a-3p ETV5 -0.748702855596996 3.93313343865641e-07 -0.145389102256725 0.355370993767523 MirTarget;miRNATAP -0.296784259819511 4.1170913506311e-09 NA NA NA hsa-miR-455-3p ETV6 -1.3998033821095 5.72010709806871e-17 -0.0931517298015985 0.289571007464479 miRNATAP -0.104390065952324 1.87950607803829e-05 NA NA NA hsa-miR-34a-5p EVC 1.03694231790865 5.74864019540594e-14 -1.28243340028546 0.000576145142605745 mirMAP -0.487682370965553 0.000141778973007783 NA NA NA hsa-miR-455-5p EVI2A -0.270546034117157 0.0581320703577731 -0.444459432480852 0.0152609111166265 miRanda -0.314821791342039 4.05973298619677e-07 NA NA NA hsa-miR-181b-5p EVI5 0.488256489401108 0.00105321129419701 -0.656558367861793 2.14847579134138e-11 mirMAP -0.108767267739994 0.000864299892478488 NA NA NA hsa-miR-30b-5p EVI5L -0.54056186708617 2.44688760798341e-05 0.640952367525351 1.90698350251893e-12 mirMAP -0.102245610947016 0.00379981373156784 NA NA NA hsa-miR-30e-5p EXO1 -0.627815042856657 3.02205690184908e-10 4.15542592055912 5.44502372441313e-52 miRNAWalker2_validate -0.72793612847533 1.08073826682895e-06 NA NA NA hsa-miR-15a-5p EXOC3L2 0.349521211668244 0.000770735998804736 0.339651138262192 0.0232394653930726 miRNATAP -0.152574398566532 0.0308234821721621 NA NA NA hsa-miR-181a-5p EXOC5 0.250113435902954 0.0551933249319293 -0.381869800654396 2.14629338906463e-06 MirTarget -0.100878423389802 0.000898836041306851 NA NA NA hsa-miR-21-5p EXOC5 1.51084295924322 1.54551622173259e-34 -0.381869800654396 2.14629338906463e-06 miRNAWalker2_validate -0.199036570313502 5.77507937444715e-12 NA NA NA hsa-miR-214-5p EXOC7 -1.91497809567701 3.92955595018147e-12 0.570694756710907 2.44771582692024e-19 mirMAP -0.10590582011501 2.96397096991005e-22 NA NA NA hsa-miR-146b-5p EXPH5 0.419719546795449 0.0457375823220155 -2.77336815804163 2.69759398127693e-14 miRanda -0.2013826258875 0.0212264089800064 NA NA NA hsa-miR-17-3p EXPH5 0.410352776142368 0.00422200500748636 -2.77336815804163 2.69759398127693e-14 MirTarget -0.98932799104929 1.3389882546919e-15 NA NA NA hsa-miR-505-5p EXT1 -0.768282569967001 1.14662846595407e-05 -0.116219835522597 0.337006077868152 MirTarget -0.114695276844317 0.000555747624544554 NA NA NA hsa-miR-30b-5p EXTL2 -0.54056186708617 2.44688760798341e-05 0.184798342946352 0.0519914137335449 MirTarget -0.126360384060306 0.000422175236311488 NA NA NA hsa-miR-99a-5p EXTL3 -1.51481656384839 3.93230057259529e-14 0.602291383610503 5.83978727779557e-08 miRNAWalker2_validate -0.111187787095505 2.48592794084231e-05 NA NA NA hsa-miR-30b-5p EYA3 -0.54056186708617 2.44688760798341e-05 -0.0554598036939685 0.758683442786551 miRNAWalker2_validate -0.160678265254225 0.0187636387266426 NA NA NA hsa-miR-194-5p EYA4 -0.292530160992458 0.0996141384876663 -0.945709764353046 0.0203125816946371 miRNATAP -0.295467350063734 0.00846741855645883 NA NA NA hsa-miR-146b-5p EYS 0.419719546795449 0.0457375823220155 -0.15480072317379 0.505593807144114 miRanda -0.129163071928746 0.0165357642024361 NA NA NA hsa-miR-34a-5p F2RL2 1.03694231790865 5.74864019540594e-14 -1.06031688649944 0.000891134254190815 MirTarget;miRNATAP -0.233344553575455 0.0345213667619734 NA NA NA hsa-miR-148a-3p F3 -0.748702855596996 3.93313343865641e-07 -1.77735272391257 4.53941856275069e-12 MirTarget -0.587483900043743 2.87917611994749e-12 NA NA NA hsa-miR-20a-5p F3 0.854326758727003 5.04256669663285e-07 -1.77735272391257 4.53941856275069e-12 MirTarget;miRNATAP -0.165197021230371 0.0273527859606424 NA NA NA hsa-miR-455-5p F3 -0.270546034117157 0.0581320703577731 -1.77735272391257 4.53941856275069e-12 miRanda -0.20140911287494 0.0260199102941347 NA NA NA hsa-miR-455-3p FA2H -1.3998033821095 5.72010709806871e-17 -1.26435011606672 0.00271055986812812 miRNATAP -0.508956969414517 1.61607396234046e-05 NA NA NA hsa-miR-192-5p FAIM -0.50188499512787 0.00344713341196035 0.589207851373054 1.02493249390092e-06 miRNAWalker2_validate -0.179088764169198 1.55634241957254e-07 NA NA NA hsa-miR-27b-3p FAM104A -0.823491817819754 9.20935302746823e-14 0.382548867340036 2.14628142056169e-09 miRNATAP -0.158596180848725 7.31027875965331e-09 NA NA NA hsa-miR-30e-5p FAM104A -0.627815042856657 3.02205690184908e-10 0.382548867340036 2.14628142056169e-09 MirTarget -0.102101126608639 0.00105901395343356 NA NA NA hsa-miR-455-3p FAM105A -1.3998033821095 5.72010709806871e-17 -0.108902489138179 0.584499658729071 MirTarget -0.314396656637551 1.06094837399212e-08 NA NA NA hsa-miR-182-5p FAM107A 1.96601340710222 4.39326175603633e-09 -0.856670386549353 7.24543915654175e-06 MirTarget -0.155308324424776 9.69411061730247e-09 NA NA NA hsa-miR-21-5p FAM107B 1.51084295924322 1.54551622173259e-34 -0.783707675483699 1.16417578511053e-13 miRNATAP -0.235074428188822 1.61942879549264e-09 NA NA NA hsa-miR-505-5p FAM109A -0.768282569967001 1.14662846595407e-05 0.0403720962657506 0.716957097286577 mirMAP -0.105787221956921 0.000530948421373902 NA NA NA hsa-miR-455-3p FAM110A -1.3998033821095 5.72010709806871e-17 0.784589325053161 7.64768894925362e-09 miRNATAP -0.150832995016169 9.26925203655611e-05 NA NA NA hsa-miR-15a-5p FAM110C 0.349521211668244 0.000770735998804736 -2.10619527169283 1.5711658097408e-10 MirTarget -0.900014411289545 8.45033657657525e-09 NA NA NA hsa-miR-19b-3p FAM114A1 0.601279551368824 0.00016685097085251 -0.535044401555146 0.000661785559182086 MirTarget;miRNATAP -0.168676737225705 0.000418032639329402 NA NA NA hsa-miR-34a-5p FAM117B 1.03694231790865 5.74864019540594e-14 0.103695795405027 0.442637591978479 MirTarget -0.266873334289491 4.60766975803414e-09 NA NA NA hsa-miR-455-5p FAM124A -0.270546034117157 0.0581320703577731 -0.648019087622329 0.00198441278706468 miRanda -0.312230381635773 1.27264285784961e-05 NA NA NA hsa-miR-146b-5p FAM124B 0.419719546795449 0.0457375823220155 0.333976493789109 0.166839315576266 miRanda -0.150123107601671 0.00733453840602192 NA NA NA hsa-miR-30b-5p FAM126A -0.54056186708617 2.44688760798341e-05 -0.313727812847248 0.0135852425322176 mirMAP -0.163637364028511 0.000665861885119853 NA NA NA hsa-miR-21-5p FAM126B 1.51084295924322 1.54551622173259e-34 -0.636777402416019 9.26093586171305e-12 miRNAWalker2_validate -0.284805117357217 2.09374309898492e-17 NA NA NA hsa-miR-34a-5p FAM126B 1.03694231790865 5.74864019540594e-14 -0.636777402416019 9.26093586171305e-12 miRNATAP -0.184139364469862 1.22562023330393e-08 NA NA NA hsa-miR-20a-5p FAM129B 0.854326758727003 5.04256669663285e-07 -0.133693429940162 0.416336428141766 miRNATAP -0.151836023746115 0.00107229987436081 NA NA NA hsa-miR-182-5p FAM134B 1.96601340710222 4.39326175603633e-09 -3.8750438495845 3.40772200182201e-21 MirTarget;miRNATAP -0.174770316910521 0.00448387286444479 NA NA NA hsa-miR-15a-5p FAM135A 0.349521211668244 0.000770735998804736 -0.0838386568716531 0.537253454241857 miRNATAP -0.253052309829325 6.78573613260252e-05 NA NA NA hsa-miR-455-5p FAM135A -0.270546034117157 0.0581320703577731 -0.0838386568716531 0.537253454241857 miRanda -0.248431955700058 5.81377948305465e-08 NA NA NA hsa-miR-221-3p FAM13A 1.12244756358612 3.48370308238012e-13 -2.57744428571964 2.57406538004678e-26 miRNATAP -0.57412851838564 1.18945467601914e-13 NA NA NA hsa-miR-222-3p FAM13A 1.08574156066353 1.76407192348131e-11 -2.57744428571964 2.57406538004678e-26 miRNATAP -0.572371574472888 1.08861980073397e-14 NA NA NA hsa-miR-409-3p FAM13A -0.499649792570937 0.0526751181520117 -2.57744428571964 2.57406538004678e-26 mirMAP -0.15172528025652 0.00187641688112002 NA NA NA hsa-miR-146b-5p FAM149A 0.419719546795449 0.0457375823220155 -1.70116988216999 2.17958552506598e-16 miRanda -0.207702603762964 2.80348629523084e-05 NA NA NA hsa-miR-19b-3p FAM149A 0.601279551368824 0.00016685097085251 -1.70116988216999 2.17958552506598e-16 MirTarget -0.237273708329273 0.000269963835237403 NA NA NA hsa-miR-19b-3p FAM155A 0.601279551368824 0.00016685097085251 -0.0108397977393486 0.967335271279681 MirTarget -0.263112950044584 0.00102530238350408 NA NA NA hsa-miR-455-5p FAM155B -0.270546034117157 0.0581320703577731 1.18777993849153 0.00400870110034955 miRanda -0.364726649952252 0.0101879699829417 NA NA NA hsa-miR-146b-5p FAM160A1 0.419719546795449 0.0457375823220155 -2.10651757735929 2.26608040482486e-12 miRanda -0.429934166551634 9.56068729086389e-10 NA NA NA hsa-miR-19b-3p FAM160A1 0.601279551368824 0.00016685097085251 -2.10651757735929 2.26608040482486e-12 MirTarget;miRNATAP -0.27150330458465 0.00376391256331231 NA NA NA hsa-miR-148a-3p FAM160B2 -0.748702855596996 3.93313343865641e-07 0.170041130884332 0.0540544370833985 mirMAP -0.161281958630114 1.22626225985271e-08 NA NA NA hsa-miR-29c-3p FAM168B -1.4367517608807 1.61767774905781e-21 0.493717680404587 1.89568382604716e-08 MirTarget -0.177881587940423 3.18908136528151e-11 NA NA NA hsa-miR-181a-5p FAM169A 0.250113435902954 0.0551933249319293 0.365458857393713 0.13290757956596 mirMAP -0.431969994641908 1.7752642666898e-06 NA NA NA hsa-miR-181b-5p FAM169A 0.488256489401108 0.00105321129419701 0.365458857393713 0.13290757956596 mirMAP -0.505002472264281 8.31683679317798e-11 NA NA NA hsa-miR-192-5p FAM171B -0.50188499512787 0.00344713341196035 0.778198641601071 0.000133185104883409 miRNAWalker2_validate -0.490320367180017 1.52905309018984e-18 NA NA NA hsa-miR-455-3p FAM171B -1.3998033821095 5.72010709806871e-17 0.778198641601071 0.000133185104883409 MirTarget;miRNATAP -0.301844785797858 1.09698373891785e-07 NA NA NA hsa-miR-146b-5p FAM174B 0.419719546795449 0.0457375823220155 -0.106516020351106 0.587388124703541 miRanda -0.187364525979081 3.34545239041714e-05 NA NA NA hsa-miR-455-5p FAM178B -0.270546034117157 0.0581320703577731 1.07705755117316 0.0127480067811912 miRanda -0.346998032460009 0.0195593664588723 NA NA NA hsa-miR-132-3p FAM184A 0.323796239695997 0.00272093067935091 -0.0143574235908157 0.956617794277901 MirTarget -0.385486854163386 0.00123227414633238 NA NA NA hsa-miR-192-5p FAM189A2 -0.50188499512787 0.00344713341196035 -0.0450400191974518 0.824442625113164 miRNAWalker2_validate -0.414168948858265 1.21955548739979e-13 NA NA NA hsa-miR-181a-5p FAM199X 0.250113435902954 0.0551933249319293 0.308382023470061 0.000848432873409528 mirMAP -0.124650964671133 0.000317620356508724 NA NA NA hsa-miR-30b-5p FAM199X -0.54056186708617 2.44688760798341e-05 0.308382023470061 0.000848432873409528 mirMAP -0.107407868382398 0.00217493873058292 NA NA NA hsa-miR-194-5p FAM19A5 -0.292530160992458 0.0996141384876663 -1.12507674916914 0.0181139725262512 miRNATAP -0.460659446660008 0.0004236166746521 NA NA NA hsa-miR-505-5p FAM19A5 -0.768282569967001 1.14662846595407e-05 -1.12507674916914 0.0181139725262512 MirTarget -0.57261112367775 1.19323076191647e-05 NA NA NA hsa-miR-192-5p FAM26E -0.50188499512787 0.00344713341196035 -0.107372888081332 0.496336542380078 mirMAP -0.304381445099328 2.8178877804066e-12 NA NA NA hsa-miR-34a-5p FAM3C 1.03694231790865 5.74864019540594e-14 -0.425935507572763 1.75944944561868e-05 miRNAWalker2_validate -0.112105984803136 0.00105420058232397 NA NA NA hsa-miR-19b-3p FAM43A 0.601279551368824 0.00016685097085251 0.150355065681873 0.433204776736207 MirTarget -0.237173412155383 4.14990571578763e-05 NA NA NA hsa-miR-30c-5p FAM43A -0.432111642767632 0.000159764714931007 0.150355065681873 0.433204776736207 MirTarget -0.207700594637365 0.0109726595373261 NA NA NA hsa-miR-181a-5p FAM46A 0.250113435902954 0.0551933249319293 -1.45135702962017 1.01521313725168e-19 mirMAP;miRNATAP -0.245116856027616 8.73890955494237e-05 NA NA NA hsa-miR-181b-5p FAM46A 0.488256489401108 0.00105321129419701 -1.45135702962017 1.01521313725168e-19 mirMAP;miRNATAP -0.242846450679644 7.43686108188156e-06 NA NA NA hsa-miR-21-5p FAM46A 1.51084295924322 1.54551622173259e-34 -1.45135702962017 1.01521313725168e-19 miRNAWalker2_validate;miRNATAP -0.306527061274061 3.82955649227577e-07 NA NA NA hsa-miR-34a-5p FAM46A 1.03694231790865 5.74864019540594e-14 -1.45135702962017 1.01521313725168e-19 miRNAWalker2_validate;miRNATAP -0.156287808687737 0.00652607908676051 NA NA NA hsa-miR-19b-3p FAM46C 0.601279551368824 0.00016685097085251 -1.65510942063513 7.80605621031549e-14 miRNATAP -0.170861861604187 0.0139178261363437 NA NA NA hsa-miR-20a-5p FAM46C 0.854326758727003 5.04256669663285e-07 -1.65510942063513 7.80605621031549e-14 MirTarget;miRNATAP -0.23687630172238 0.000240559026938884 NA NA NA hsa-miR-181a-5p FAM47E 0.250113435902954 0.0551933249319293 0.197698893797714 0.232506817700832 mirMAP -0.17976211110592 0.00374992124986447 NA NA NA hsa-miR-181b-5p FAM47E 0.488256489401108 0.00105321129419701 0.197698893797714 0.232506817700832 mirMAP -0.224877980302697 2.77476364991836e-05 NA NA NA hsa-miR-148a-3p FAM53B -0.748702855596996 3.93313343865641e-07 0.971989850032648 4.87327424473216e-17 mirMAP -0.286212044971369 6.7551492819291e-14 NA NA NA hsa-miR-455-3p FAM53B -1.3998033821095 5.72010709806871e-17 0.971989850032648 4.87327424473216e-17 mirMAP -0.242637606056605 1.47753123986305e-13 NA NA NA hsa-miR-505-5p FAM53B -0.768282569967001 1.14662846595407e-05 0.971989850032648 4.87327424473216e-17 mirMAP -0.181629768912623 2.9353326207262e-08 NA NA NA hsa-miR-194-5p FAM60A -0.292530160992458 0.0996141384876663 0.192304077099517 0.226575212179834 miRNATAP -0.22963468284151 9.79469304222854e-08 NA NA NA hsa-miR-192-3p FAM63B -0.6401165114007 0.000266272092403814 -0.544563365894281 0.0024060920267518 mirMAP -0.106418873882892 0.0326877036091168 NA NA NA hsa-miR-192-5p FAM63B -0.50188499512787 0.00344713341196035 -0.544563365894281 0.0024060920267518 miRNAWalker2_validate -0.105779153820658 0.0385950551807212 NA NA NA hsa-miR-194-5p FAM63B -0.292530160992458 0.0996141384876663 -0.544563365894281 0.0024060920267518 miRNATAP -0.120967343111853 0.0145447416312058 NA NA NA hsa-miR-21-5p FAM63B 1.51084295924322 1.54551622173259e-34 -0.544563365894281 0.0024060920267518 miRNATAP -0.211932275839677 0.00123083612197724 NA NA NA hsa-miR-132-3p FAM76B 0.323796239695997 0.00272093067935091 -0.0783398811392955 0.464123853512256 MirTarget;miRNATAP -0.114168670927427 0.0183148626887107 NA NA NA hsa-miR-192-5p FAM78A -0.50188499512787 0.00344713341196035 0.0903525081525882 0.529997378795919 mirMAP -0.289851963096595 2.44007378015315e-13 NA NA NA hsa-miR-27b-3p FAM78A -0.823491817819754 9.20935302746823e-14 0.0903525081525882 0.529997378795919 MirTarget;miRNATAP -0.225735536898208 0.000248369174004847 NA NA NA hsa-miR-15a-5p FAM84B 0.349521211668244 0.000770735998804736 0.0375117314354485 0.82270733370101 MirTarget -0.29000185149676 0.000216507931735501 NA NA NA hsa-miR-20b-5p FAM84B 0.457668023910379 0.0285865211936156 0.0375117314354485 0.82270733370101 mirMAP;miRNATAP -0.186247977760559 1.33840660277679e-06 NA NA NA hsa-miR-99b-5p FAM8A1 -0.204769880349524 0.240836989110525 -0.45284131007862 0.00119725011194704 miRNAWalker2_validate -0.161477323321825 3.49793183489786e-05 NA NA NA hsa-miR-27b-3p FAM98A -0.823491817819754 9.20935302746823e-14 0.0180974020493805 0.783041392639418 miRNATAP -0.102008237447877 0.000262123037598327 NA NA NA hsa-miR-192-5p FANCI -0.50188499512787 0.00344713341196035 2.58883645204084 1.64497704333454e-42 miRNAWalker2_validate -0.176796714534105 0.00303346372639052 NA NA NA hsa-miR-30c-5p FAP -0.432111642767632 0.000159764714931007 2.71241298924825 4.48305215459696e-14 miRNATAP -0.403412537500498 0.0108115583538576 NA NA NA hsa-miR-455-5p FAR1 -0.270546034117157 0.0581320703577731 -0.280233283195839 0.0657019089165307 miRanda -0.227522864665785 1.09585981196135e-05 NA NA NA hsa-miR-21-5p FAS 1.51084295924322 1.54551622173259e-34 -1.01888565147264 1.11378826495697e-07 miRNAWalker2_validate -0.345881974093154 8.950367188801e-07 24710931 miR 21 targets Fas ligand mediated apoptosis in breast cancer cell line MCF 7 breast cancer hsa-miR-181a-5p FAT1 0.250113435902954 0.0551933249319293 0.764603807824783 8.63239772873677e-05 miRNAWalker2_validate -0.302330521948381 3.62532727580462e-05 NA NA NA hsa-miR-15a-5p FAT3 0.349521211668244 0.000770735998804736 -0.401092487292614 0.118283580636844 MirTarget;miRNATAP -0.270239575899031 0.0256997057587497 NA NA NA hsa-miR-34a-5p FAT3 1.03694231790865 5.74864019540594e-14 -0.401092487292614 0.118283580636844 miRNATAP -0.404119366173049 3.83303791268222e-06 NA NA NA hsa-miR-132-3p FAT4 0.323796239695997 0.00272093067935091 -1.89155225461558 9.6858796116854e-13 miRNAWalker2_validate -0.291451991410502 0.0186182646760671 NA NA NA hsa-miR-15a-5p FAT4 0.349521211668244 0.000770735998804736 -1.89155225461558 9.6858796116854e-13 MirTarget -0.501508511944067 8.8378238339135e-05 NA NA NA hsa-miR-20a-5p FAT4 0.854326758727003 5.04256669663285e-07 -1.89155225461558 9.6858796116854e-13 MirTarget;miRNATAP -0.496036601832729 5.58352564019072e-11 NA NA NA hsa-miR-34a-5p FAT4 1.03694231790865 5.74864019540594e-14 -1.89155225461558 9.6858796116854e-13 MirTarget -0.210954869223682 0.0245807374316747 NA NA NA hsa-miR-192-5p FBN1 -0.50188499512787 0.00344713341196035 0.042762327488989 0.844747911420757 miRNAWalker2_validate -0.450531498850048 6.18310358582424e-14 NA NA NA hsa-miR-21-5p FBXL17 1.51084295924322 1.54551622173259e-34 -0.248708925063077 0.00488542308997094 miRNAWalker2_validate;miRNATAP -0.189629901093539 2.1369479396319e-09 NA NA NA hsa-miR-148a-3p FBXL19 -0.748702855596996 3.93313343865641e-07 1.09129763767905 3.05430880690495e-25 miRNATAP -0.383651844314371 1.41544005302887e-29 NA NA NA hsa-miR-455-3p FBXL19 -1.3998033821095 5.72010709806871e-17 1.09129763767905 3.05430880690495e-25 miRNATAP -0.185642228596347 1.59036318159426e-09 NA NA NA hsa-miR-132-3p FBXL20 0.323796239695997 0.00272093067935091 -0.0426660274453414 0.62109119303902 MirTarget -0.105426647856469 0.00674806847952577 NA NA NA hsa-miR-20a-5p FBXL5 0.854326758727003 5.04256669663285e-07 -0.357457961344926 0.000593569927680263 miRNATAP -0.207724562110672 5.42148505974551e-13 NA NA NA hsa-miR-455-5p FBXL7 -0.270546034117157 0.0581320703577731 0.390910139697845 0.0287747821329142 miRanda;miRNATAP -0.137950527605349 0.0245392591590159 NA NA NA hsa-miR-132-3p FBXO21 0.323796239695997 0.00272093067935091 -0.791852341837471 6.92465708640045e-12 MirTarget -0.162594104850524 0.00240801191945601 NA NA NA hsa-miR-132-3p FBXO28 0.323796239695997 0.00272093067935091 -0.503712735174914 1.26784281427187e-10 miRNAWalker2_validate;MirTarget -0.149169415605744 3.32287468586214e-05 NA NA NA hsa-miR-19b-3p FBXO28 0.601279551368824 0.00016685097085251 -0.503712735174914 1.26784281427187e-10 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.116308601989409 1.24256942252833e-06 NA NA NA hsa-miR-20a-5p FBXO28 0.854326758727003 5.04256669663285e-07 -0.503712735174914 1.26784281427187e-10 MirTarget;miRNATAP -0.12845013161489 7.68431904164944e-09 NA NA NA hsa-miR-21-5p FBXO28 1.51084295924322 1.54551622173259e-34 -0.503712735174914 1.26784281427187e-10 MirTarget -0.193267594867859 1.05986699358805e-11 NA NA NA hsa-miR-15a-5p FBXO3 0.349521211668244 0.000770735998804736 -0.544237692707206 2.24798669719614e-09 miRNAWalker2_validate -0.219489938540422 3.51893377260061e-07 NA NA NA hsa-miR-20a-5p FBXO3 0.854326758727003 5.04256669663285e-07 -0.544237692707206 2.24798669719614e-09 miRNAWalker2_validate;mirMAP -0.131693301098245 3.74930518188946e-07 25115392 F box protein FBXO31 is down regulated in gastric cancer and negatively regulated by miR 17 and miR 20a; miR-20a and miR-17 directly bind to the 3'-UTR of FBXO31; Moreover a highly significant negative correlation between miR-20a miR-17 and FBXO31 was observed in these GC samples gastric cancer hsa-miR-21-5p FBXO3 1.51084295924322 1.54551622173259e-34 -0.544237692707206 2.24798669719614e-09 miRNAWalker2_validate -0.271169014440239 7.74693142357381e-17 NA NA NA hsa-miR-20a-5p FBXO31 0.854326758727003 5.04256669663285e-07 -0.0963682529727059 0.572770500648494 MirTarget -0.168739569512217 0.000460471078682578 25115392 F box protein FBXO31 is down regulated in gastric cancer and negatively regulated by miR 17 and miR 20a; miR-20a and miR-17 directly bind to the 3'-UTR of FBXO31; Moreover a highly significant negative correlation between miR-20a miR-17 and FBXO31 was observed in these GC samples gastric cancer hsa-miR-20b-5p FBXO31 0.457668023910379 0.0285865211936156 -0.0963682529727059 0.572770500648494 MirTarget -0.191573362559307 1.10711377168564e-06 NA NA NA hsa-miR-192-3p FBXO32 -0.6401165114007 0.000266272092403814 1.49973264070402 1.35888111194844e-11 mirMAP -0.416011661149065 1.26508248581647e-11 NA NA NA hsa-miR-19b-3p FBXO32 0.601279551368824 0.00016685097085251 1.49973264070402 1.35888111194844e-11 miRNATAP -0.23913099726224 0.000520544202177325 NA NA NA hsa-miR-27b-3p FBXO32 -0.823491817819754 9.20935302746823e-14 1.49973264070402 1.35888111194844e-11 miRNATAP -0.516688019767081 9.38353902752944e-08 NA NA NA hsa-miR-455-3p FBXO32 -1.3998033821095 5.72010709806871e-17 1.49973264070402 1.35888111194844e-11 mirMAP -0.352227247366592 2.18536409018519e-08 NA NA NA hsa-miR-181a-5p FBXO33 0.250113435902954 0.0551933249319293 -0.47614236683939 5.37442717754754e-09 miRNAWalker2_validate -0.23481886107701 5.91332203585103e-15 NA NA NA hsa-miR-455-5p FBXO36 -0.270546034117157 0.0581320703577731 -0.206059790196518 0.217688338229136 miRanda -0.136694073392541 0.0168975485696667 NA NA NA hsa-miR-29c-3p FBXO41 -1.4367517608807 1.61767774905781e-21 0.395728773948549 0.102434434149993 mirMAP -0.254522009395784 0.000622584697660373 NA NA NA hsa-miR-34a-5p FBXO41 1.03694231790865 5.74864019540594e-14 0.395728773948549 0.102434434149993 miRNATAP -0.299583992823395 0.000304458349195353 NA NA NA hsa-miR-455-3p FBXO41 -1.3998033821095 5.72010709806871e-17 0.395728773948549 0.102434434149993 mirMAP -0.277232400564266 4.13214296315626e-05 NA NA NA hsa-miR-127-3p FBXO43 -1.0751374948053 2.19322892330221e-05 3.60741474977024 2.47094293559151e-45 miRanda -0.154688751504431 0.00448610112850301 NA NA NA hsa-miR-19b-3p FBXO8 0.601279551368824 0.00016685097085251 -0.896460803945479 2.93921441385328e-15 miRNAWalker2_validate;MirTarget;miRNATAP -0.11820418596249 0.000894355302291768 NA NA NA hsa-miR-29c-3p FBXW9 -1.4367517608807 1.61767774905781e-21 0.568770156870279 3.73483037838346e-08 MirTarget -0.237307474454707 3.44722165527056e-14 NA NA NA hsa-miR-30b-5p FEM1B -0.54056186708617 2.44688760798341e-05 -0.348276122234088 4.42827856481569e-05 miRNAWalker2_validate;mirMAP -0.103773581048256 0.00135927957774334 NA NA NA hsa-miR-132-3p FEM1C 0.323796239695997 0.00272093067935091 -0.503681375330292 2.07828929078027e-07 MirTarget;miRNATAP -0.185437704227971 2.74421142806005e-05 NA NA NA hsa-miR-20a-5p FEM1C 0.854326758727003 5.04256669663285e-07 -0.503681375330292 2.07828929078027e-07 MirTarget;miRNATAP -0.101327781636578 0.000253456735866326 NA NA NA hsa-miR-192-3p FERMT1 -0.6401165114007 0.000266272092403814 1.14528954642755 0.00602104982484306 mirMAP -0.575034714180058 4.94333244362454e-07 NA NA NA hsa-miR-192-5p FERMT1 -0.50188499512787 0.00344713341196035 1.14528954642755 0.00602104982484306 miRNAWalker2_validate -0.516729220766827 1.146972710071e-05 NA NA NA hsa-miR-215-5p FERMT1 -0.981544773246509 3.14452272477156e-05 1.14528954642755 0.00602104982484306 miRNAWalker2_validate -0.469246711974141 2.79946913503497e-08 NA NA NA hsa-miR-21-5p FERMT2 1.51084295924322 1.54551622173259e-34 -1.17471907439772 6.50761494287311e-25 miRNAWalker2_validate -0.471357960010248 1.37679112814546e-30 NA NA NA hsa-miR-221-3p FERMT2 1.12244756358612 3.48370308238012e-13 -1.17471907439772 6.50761494287311e-25 MirTarget;miRNATAP -0.153189097329362 3.36111787442557e-05 NA NA NA hsa-miR-222-3p FERMT2 1.08574156066353 1.76407192348131e-11 -1.17471907439772 6.50761494287311e-25 MirTarget;miRNATAP -0.186527634714023 1.17564460119085e-07 NA NA NA hsa-miR-181a-5p FGD4 0.250113435902954 0.0551933249319293 -1.15544171645474 1.45947973849956e-12 miRNATAP -0.192535835038674 0.00220252041003175 NA NA NA hsa-miR-181b-5p FGD4 0.488256489401108 0.00105321129419701 -1.15544171645474 1.45947973849956e-12 mirMAP -0.208491827217426 0.000131797572532732 NA NA NA hsa-miR-20a-5p FGD4 0.854326758727003 5.04256669663285e-07 -1.15544171645474 1.45947973849956e-12 MirTarget -0.339502877510144 2.09715099852461e-13 NA NA NA hsa-miR-21-5p FGD4 1.51084295924322 1.54551622173259e-34 -1.15544171645474 1.45947973849956e-12 MirTarget -0.493369028543639 6.13846194813968e-17 NA NA NA hsa-miR-20a-5p FGD5 0.854326758727003 5.04256669663285e-07 -0.0869101677163209 0.581625732970603 MirTarget;miRNATAP -0.120006135249983 0.00711832346596723 NA NA NA hsa-miR-34a-5p FGD6 1.03694231790865 5.74864019540594e-14 0.314033910840616 0.0439181907931429 MirTarget;miRNATAP -0.207709284699254 9.69646132436628e-05 NA NA NA hsa-miR-455-5p FGF12 -0.270546034117157 0.0581320703577731 1.12701565396445 0.000125070474588253 miRanda -0.2955118739476 0.00352688948327299 NA NA NA hsa-miR-455-5p FGF13 -0.270546034117157 0.0581320703577731 1.04387202836938 0.000243713997792116 PITA;miRanda -0.315950161217624 0.00124978729248725 NA NA NA hsa-miR-181a-5p FGF2 0.250113435902954 0.0551933249319293 -1.08625533231299 0.000324809942833161 mirMAP -0.406045352280239 0.000358497143826792 NA NA NA hsa-miR-181b-5p FGF2 0.488256489401108 0.00105321129419701 -1.08625533231299 0.000324809942833161 mirMAP -0.523910277677257 9.1015168945214e-08 NA NA NA hsa-miR-21-5p FGF2 1.51084295924322 1.54551622173259e-34 -1.08625533231299 0.000324809942833161 mirMAP -0.443381765546842 5.91228766084995e-05 NA NA NA hsa-miR-215-5p FGF2 -0.981544773246509 3.14452272477156e-05 -1.08625533231299 0.000324809942833161 miRNAWalker2_validate -0.153448795618752 0.0138240489461602 NA NA NA hsa-miR-222-3p FGF2 1.08574156066353 1.76407192348131e-11 -1.08625533231299 0.000324809942833161 mirMAP -0.206975558906397 0.0212088626227192 NA NA NA hsa-miR-15a-5p FGF7 0.349521211668244 0.000770735998804736 -0.653895802717462 0.00602323864930533 miRTarBase;miRNATAP -0.366019587762154 0.00111409761072969 NA NA NA hsa-miR-20a-5p FGF7 0.854326758727003 5.04256669663285e-07 -0.653895802717462 0.00602323864930533 miRNAWalker2_validate -0.341470101333498 3.32475785382172e-07 NA NA NA hsa-miR-455-3p FGF7 -1.3998033821095 5.72010709806871e-17 -0.653895802717462 0.00602323864930533 PITA;miRNATAP -0.173570787405519 0.00961793201913047 NA NA NA hsa-miR-15a-5p FGFR1 0.349521211668244 0.000770735998804736 -1.10351511026112 4.12675064572266e-07 miRNATAP -0.352840830794253 0.000677757595811867 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-20a-5p FGFR1 0.854326758727003 5.04256669663285e-07 -1.10351511026112 4.12675064572266e-07 mirMAP -0.287282538249605 3.68706352846777e-06 NA NA NA hsa-miR-455-5p FGFR1 -0.270546034117157 0.0581320703577731 -1.10351511026112 4.12675064572266e-07 miRanda -0.249494978181263 0.000949827332507152 NA NA NA hsa-miR-146b-5p FGFR2 0.419719546795449 0.0457375823220155 -2.28582334954307 1.14765468936708e-05 miRanda -0.240513289535335 0.0492394721603946 NA NA NA hsa-miR-99a-5p FGFR3 -1.51481656384839 3.93230057259529e-14 0.189024805500786 0.340204942325551 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.302096873169716 3.68370160731018e-11 23409016;24456664;23298836 Photofrin based photodynamic therapy and miR 99a transfection inhibited FGFR3 and PI3K/Akt signaling mechanisms to control growth of human glioblastoma In vitro and in vivo; Further photofrin based PDT followed by miR-99a transfection dramatically increased miR-99a expression and also increased apoptosis in glioblastoma cell cultures and drastically reduced tumor growth in athymic nude mice due to down regulation of fibroblast growth factor receptor 3 FGFR3 and PI3K/Akt signaling mechanisms leading to inhibition of cell proliferation and induction of molecular mechanisms of apoptosis;miR 99a promotes proliferation targeting FGFR3 in human epithelial ovarian cancer cells; Importantly fibroblast growth factor receptor 3 FGFR3 predicted to be one target gene of miR-99a using computational algorithms was higher in expression in EOC cells; Subsequently FGFR3 was proved to be direct target of miR-99a by dual luciferase assay; Furthermore overexpression of miR-99a dramatically suppressed expression level of FGFR3 at both mRNA and protein levels proving FGFR3 to be inversely correlated with miR-99a; Finally overexpression of miR-99a could significantly inhibit EOC cell proliferation in vitro by decreasing the expression of FGFR3 which also reduced the EOC cell growth after siRNA knockdown; Conclusively miR-99a expression was remarkably downregulated in serums tissues and cell and suppresses EOC cell proliferation by targeting FGFR3 suggesting miR-99a as a prospective prognosis marker and potential tumor suppressor for EOC therapeutics;The tumorigenic FGFR3 TACC3 gene fusion escapes miR 99a regulation in glioblastoma; The fusion caused by tandem duplication on 4p16.3 led to the loss of the 3'-UTR of FGFR3 blocking gene regulation of miR-99a and enhancing expression of the fusion gene ;worse prognosis; glioblastoma;ovarian cancer;glioblastoma hsa-miR-20a-5p FGL2 0.854326758727003 5.04256669663285e-07 -1.57400116275033 9.67186609155287e-17 MirTarget -0.296408617212126 7.39384140087011e-08 NA NA NA hsa-miR-192-5p FHDC1 -0.50188499512787 0.00344713341196035 1.32319998637117 1.26356481591792e-07 miRNAWalker2_validate;MirTarget -0.438392625074586 5.7916971813987e-10 NA NA NA hsa-miR-146b-5p FHL2 0.419719546795449 0.0457375823220155 -1.48982772048475 2.74414125249484e-09 miRanda;mirMAP -0.131171257395469 0.027007125905475 NA NA NA hsa-miR-20a-5p FHL2 0.854326758727003 5.04256669663285e-07 -1.48982772048475 2.74414125249484e-09 mirMAP -0.569805616964817 3.57503576277774e-16 NA NA NA hsa-miR-146b-5p FHOD3 0.419719546795449 0.0457375823220155 -1.00261027183315 0.00467927048807083 miRanda -0.167185768583039 0.0430574186953302 NA NA NA hsa-miR-19b-3p FIBIN 0.601279551368824 0.00016685097085251 -1.08654865070202 0.00125372317323056 MirTarget -0.241006830640231 0.0192083674495353 NA NA NA hsa-miR-20a-5p FIBIN 0.854326758727003 5.04256669663285e-07 -1.08654865070202 0.00125372317323056 MirTarget -0.380954691513929 6.51644464790147e-05 NA NA NA hsa-miR-34a-5p FIGN 1.03694231790865 5.74864019540594e-14 -1.19617153168227 1.17312640494732e-06 miRNAWalker2_validate -0.556745400143642 2.98329351701962e-11 NA NA NA hsa-miR-455-5p FILIP1 -0.270546034117157 0.0581320703577731 -0.581375453321553 0.00446585031212186 miRanda -0.240043534748272 0.00061038005838437 NA NA NA hsa-miR-21-5p FILIP1L 1.51084295924322 1.54551622173259e-34 -1.18591508212985 2.30526943213347e-11 miRNAWalker2_validate -0.219368868643445 0.000918628151324769 NA NA NA hsa-miR-20a-5p FJX1 0.854326758727003 5.04256669663285e-07 -0.0578285980687501 0.721991012392702 MirTarget;miRNATAP -0.158121392126183 0.000558689914263595 NA NA NA hsa-miR-132-3p FKBP2 0.323796239695997 0.00272093067935091 -0.0668978537337681 0.603383957658749 MirTarget;miRNATAP -0.229859127495602 7.24444565202434e-05 NA NA NA hsa-miR-146a-5p FKBP5 -0.742958238440575 0.000765983177482633 -0.232073250029758 0.19420333201796 mirMAP -0.124142801797377 0.00151625495753003 NA NA NA hsa-miR-20a-5p FKBP5 0.854326758727003 5.04256669663285e-07 -0.232073250029758 0.19420333201796 mirMAP -0.229419740768159 4.84211785897638e-06 NA NA NA hsa-miR-20b-5p FKBP5 0.457668023910379 0.0285865211936156 -0.232073250029758 0.19420333201796 mirMAP -0.113231438364862 0.00646584588622917 NA NA NA hsa-miR-221-3p FKBP5 1.12244756358612 3.48370308238012e-13 -0.232073250029758 0.19420333201796 mirMAP -0.219251177999315 5.95058700008135e-05 NA NA NA hsa-miR-222-3p FKBP5 1.08574156066353 1.76407192348131e-11 -0.232073250029758 0.19420333201796 mirMAP -0.247025035708644 2.22579520028561e-06 NA NA NA hsa-miR-181a-5p FKBP7 0.250113435902954 0.0551933249319293 -0.722672710779835 2.24696522041559e-09 miRNAWalker2_validate -0.133117322230264 0.00392375978416666 NA NA NA hsa-miR-192-5p FLI1 -0.50188499512787 0.00344713341196035 -0.394821639499866 0.00277147867169758 MirTarget -0.230615224508645 3.6514514909311e-10 NA NA NA hsa-miR-194-5p FLI1 -0.292530160992458 0.0996141384876663 -0.394821639499866 0.00277147867169758 MirTarget -0.213599692299006 2.24971743584367e-09 NA NA NA hsa-miR-146b-5p FLNA 0.419719546795449 0.0457375823220155 0.227340527470956 0.203430797039815 miRanda -0.102330131350885 0.0135007435750139 NA NA NA hsa-miR-20a-5p FLNA 0.854326758727003 5.04256669663285e-07 0.227340527470956 0.203430797039815 miRNAWalker2_validate -0.238395501979443 1.97781492413483e-06 NA NA NA hsa-miR-455-5p FLNC -0.270546034117157 0.0581320703577731 1.11832216142873 0.00729726825244788 miRanda -0.448018525003576 0.00172675169218686 NA NA NA hsa-miR-148a-3p FLOT2 -0.748702855596996 3.93313343865641e-07 0.174241659619787 0.0839095721996099 MirTarget -0.135661337188965 3.25812696544883e-05 NA NA NA hsa-miR-192-3p FLRT2 -0.6401165114007 0.000266272092403814 -2.1592326653748 8.94227258133224e-11 mirMAP -0.560409186911759 1.41677961000714e-09 NA NA NA hsa-miR-19b-3p FLT1 0.601279551368824 0.00016685097085251 0.348253937407654 0.00775687550206773 MirTarget -0.106879008818879 0.00722041764726757 NA NA NA hsa-miR-20a-5p FLT1 0.854326758727003 5.04256669663285e-07 0.348253937407654 0.00775687550206773 MirTarget;miRNATAP -0.123502068793973 0.000848936793187574 NA NA NA hsa-miR-30b-5p FLVCR1 -0.54056186708617 2.44688760798341e-05 2.21281107028163 8.50446492402864e-36 MirTarget -0.252454448010611 0.000559312012491533 NA NA NA hsa-miR-30c-5p FLVCR1 -0.432111642767632 0.000159764714931007 2.21281107028163 8.50446492402864e-36 MirTarget -0.376677248806012 4.10707469010809e-06 NA NA NA hsa-miR-30e-5p FLVCR1 -0.627815042856657 3.02205690184908e-10 2.21281107028163 8.50446492402864e-36 MirTarget -0.446412072863694 1.45488830883506e-06 NA NA NA hsa-miR-30b-5p FLVCR2 -0.54056186708617 2.44688760798341e-05 -0.706439528484593 1.88281473202466e-05 MirTarget;miRNATAP -0.144712934169552 0.0220613314472681 NA NA NA hsa-miR-20a-5p FMN1 0.854326758727003 5.04256669663285e-07 -0.641575890494061 0.0277147350428254 mirMAP -0.399544884856271 1.06761398743688e-06 NA NA NA hsa-miR-17-3p FMNL2 0.410352776142368 0.00422200500748636 0.0524311775006261 0.807723354715146 MirTarget -0.320301894789811 1.02185223670974e-05 NA NA NA hsa-miR-455-3p FMNL2 -1.3998033821095 5.72010709806871e-17 0.0524311775006261 0.807723354715146 MirTarget;PITA -0.302433340476635 4.06914617593792e-07 NA NA NA hsa-miR-455-5p FMNL2 -0.270546034117157 0.0581320703577731 0.0524311775006261 0.807723354715146 miRanda -0.367741015620147 4.47834428991664e-07 NA NA NA hsa-miR-148a-3p FMNL3 -0.748702855596996 3.93313343865641e-07 0.665131482558671 1.67762417764945e-07 miRNATAP -0.454255007976079 2.93997652908655e-31 NA NA NA hsa-miR-182-5p FMO2 1.96601340710222 4.39326175603633e-09 -1.96300403692723 1.00033705253178e-10 MirTarget -0.164079151212685 0.000200103403157759 NA NA NA hsa-miR-432-5p FMO4 -0.536178819038888 0.0748623258271085 -1.24749117913486 9.83691192348328e-09 MirTarget -0.193790226500881 4.65585275542207e-08 NA NA NA hsa-miR-132-3p FMR1 0.323796239695997 0.00272093067935091 0.0205799660201702 0.848215525236684 miRNATAP -0.299746675589384 3.132406512068e-10 NA NA NA hsa-miR-21-5p FMR1 1.51084295924322 1.54551622173259e-34 0.0205799660201702 0.848215525236684 miRNAWalker2_validate -0.179786227316967 3.48177677419723e-06 NA NA NA hsa-miR-17-3p FNBP1L 0.410352776142368 0.00422200500748636 0.327459444323646 0.00322091956560441 miRNATAP -0.157660012709648 2.75999290426033e-05 NA NA NA hsa-miR-181a-5p FNDC3A 0.250113435902954 0.0551933249319293 -0.995884475839302 2.03718393267477e-13 MirTarget;miRNATAP -0.207008115112334 7.12332091953693e-05 NA NA NA hsa-miR-181b-5p FNDC3A 0.488256489401108 0.00105321129419701 -0.995884475839302 2.03718393267477e-13 MirTarget;mirMAP;miRNATAP -0.173833003664333 0.000127087539454222 NA NA NA hsa-miR-19b-3p FNDC3A 0.601279551368824 0.00016685097085251 -0.995884475839302 2.03718393267477e-13 miRNATAP -0.151665346229029 0.00033164117545523 NA NA NA hsa-miR-20a-5p FNDC3A 0.854326758727003 5.04256669663285e-07 -0.995884475839302 2.03718393267477e-13 MirTarget;miRNATAP -0.163778149537746 3.08732263491971e-05 NA NA NA hsa-miR-20b-5p FNDC3A 0.457668023910379 0.0285865211936156 -0.995884475839302 2.03718393267477e-13 MirTarget;miRNATAP -0.14121269012965 1.20917406560379e-05 NA NA NA hsa-miR-221-3p FNDC3A 1.12244756358612 3.48370308238012e-13 -0.995884475839302 2.03718393267477e-13 MirTarget;miRNATAP -0.14342992972706 0.000806093199924562 NA NA NA hsa-miR-222-3p FNDC3A 1.08574156066353 1.76407192348131e-11 -0.995884475839302 2.03718393267477e-13 MirTarget;miRNATAP -0.143341801783073 0.000479622188870539 NA NA NA hsa-miR-34a-5p FNDC3B 1.03694231790865 5.74864019540594e-14 -0.181974575670901 0.0863787981395837 miRNATAP -0.182675032059125 3.7849592109728e-07 NA NA NA hsa-miR-146b-5p FNDC5 0.419719546795449 0.0457375823220155 -2.06928347545742 5.81031480759579e-06 miRanda -0.479632161901838 6.26683189292803e-06 NA NA NA hsa-miR-20a-5p FNIP2 0.854326758727003 5.04256669663285e-07 -1.97277564777211 1.79187762303784e-13 MirTarget -0.233422413182353 0.0028341350099152 NA NA NA hsa-miR-221-3p FOS 1.12244756358612 3.48370308238012e-13 -3.63859914445361 9.27794861825719e-37 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.561899061238752 3.60354241869353e-09 NA NA NA hsa-miR-222-3p FOS 1.08574156066353 1.76407192348131e-11 -3.63859914445361 9.27794861825719e-37 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.444477688664767 1.35122650868218e-06 NA NA NA hsa-miR-19b-3p FOSL1 0.601279551368824 0.00016685097085251 -1.28809880442401 1.10466405136613e-07 MirTarget -0.20838470159538 0.00535183413101081 NA NA NA hsa-miR-17-3p FOSL2 0.410352776142368 0.00422200500748636 -0.435467547734661 0.00385233400608047 mirMAP -0.362907768395134 3.86353274361459e-13 NA NA NA hsa-miR-132-3p FOXA1 0.323796239695997 0.00272093067935091 -0.316495621757761 0.0845543462338977 miRNATAP -0.335543633392833 5.00622001202614e-05 NA NA NA hsa-miR-148a-3p FOXF1 -0.748702855596996 3.93313343865641e-07 -1.93657438569129 8.48580930399672e-18 MirTarget -0.314860376896413 3.72189697847819e-05 NA NA NA hsa-miR-20a-5p FOXJ2 0.854326758727003 5.04256669663285e-07 0.0215239532173994 0.812716242710092 MirTarget;miRNATAP -0.107015818950805 2.59631251490628e-05 NA NA NA hsa-miR-148a-3p FOXK1 -0.748702855596996 3.93313343865641e-07 1.204250755958 4.1435634806038e-25 mirMAP -0.278355247713312 1.45950739758757e-12 NA NA NA hsa-miR-27b-3p FOXK1 -0.823491817819754 9.20935302746823e-14 1.204250755958 4.1435634806038e-25 mirMAP -0.211784357880967 6.26620134274736e-05 NA NA NA hsa-miR-29c-3p FOXK1 -1.4367517608807 1.61767774905781e-21 1.204250755958 4.1435634806038e-25 mirMAP -0.329125950836106 1.40261952865962e-19 NA NA NA hsa-miR-30e-5p FOXK1 -0.627815042856657 3.02205690184908e-10 1.204250755958 4.1435634806038e-25 mirMAP -0.224390580090763 0.000159248962347663 NA NA NA hsa-miR-455-3p FOXK1 -1.3998033821095 5.72010709806871e-17 1.204250755958 4.1435634806038e-25 mirMAP -0.200566776468247 3.99266134199477e-09 NA NA NA hsa-miR-148a-3p FOXK2 -0.748702855596996 3.93313343865641e-07 0.559422556682597 5.5934596281655e-10 miRNATAP -0.122231023757654 4.16509173410562e-05 NA NA NA hsa-miR-29c-3p FOXK2 -1.4367517608807 1.61767774905781e-21 0.559422556682597 5.5934596281655e-10 mirMAP -0.177638041727401 1.40873741301047e-10 NA NA NA hsa-miR-34a-5p FOXN2 1.03694231790865 5.74864019540594e-14 -0.0753584354365984 0.522442317679656 miRNATAP -0.109059871152988 0.00685698778688431 NA NA NA hsa-miR-132-3p FOXN3 0.323796239695997 0.00272093067935091 -0.433290741984388 5.6274900890093e-05 MirTarget;miRNATAP -0.272998021398564 1.63242020926016e-08 NA NA NA hsa-miR-182-5p FOXN3 1.96601340710222 4.39326175603633e-09 -0.433290741984388 5.6274900890093e-05 MirTarget;miRNATAP -0.116228670061793 7.26386847508075e-15 NA NA NA hsa-miR-21-5p FOXN3 1.51084295924322 1.54551622173259e-34 -0.433290741984388 5.6274900890093e-05 miRNAWalker2_validate;mirMAP -0.363687314557807 3.15767982646235e-22 NA NA NA hsa-miR-132-3p FOXO1 0.323796239695997 0.00272093067935091 -1.85047773748744 1.95333497559347e-31 miRNAWalker2_validate -0.438272020728244 1.02204518632321e-08 26298723 miR 132 upregulation promotes gastric cancer cell growth through suppression of FoxO1 translation; Bioinformatics analyses showed that miR-132 bound to 3'-untranslated region 3'-UTR of FoxO1 messenger RNA mRNA to prevent its translation which was confirmed by luciferase reporter assay; Moreover miR-132-mediated suppression of FoxO1 in GC cells resulted in a significant increase in GC cell growth in vitro and in vivo while increases in FoxO1 by expression of antisense of miR-132 significantly decreased GC cell growth in vitro and in vivo; Together our data suggest that miR-132 upregulation in GC cells may promote cell growth through suppression of FoxO1 translation gastric cancer hsa-miR-182-5p FOXO1 1.96601340710222 4.39326175603633e-09 -1.85047773748744 1.95333497559347e-31 miRNAWalker2_validate;miRTarBase;miRNATAP -0.158607289905668 3.16942463086285e-11 24865442;26640590;23313739 Immunohistochemical analysis revealed that the levels of FOXO1 and FOXO3A two potential miR-182 targets are reduced in AA tumors;MiR 182 Is Associated with Growth Migration and Invasion in Prostate Cancer via Suppression of FOXO1; Our findings suggest that miR-182 may act to increase prostate cancer proliferation migration and invasion through suppression of FOXO1;Western blot flow cytometry and pathway analysis for the HeLa cells with miR-182 over/down-expression in vitro showed that miR-182 was involved in apoptosis and cell cycle pathways it also associated with the regulation of FOXO1 ;; colon cancer;prostate cancer;cervical and endocervical cancer hsa-miR-224-3p FOXO1 1.40770116795301 1.31426607144612e-08 -1.85047773748744 1.95333497559347e-31 mirMAP -0.137768717679753 3.61947664123796e-05 NA NA NA hsa-miR-132-3p FOXP1 0.323796239695997 0.00272093067935091 0.13330392204595 0.183148877784263 miRNATAP -0.103018897349895 0.0229903551481808 NA NA NA hsa-miR-19b-3p FOXP2 0.601279551368824 0.00016685097085251 -3.24994941369723 1.71142859920958e-14 MirTarget;miRNATAP -0.264901775376226 0.0470280989948514 NA NA NA hsa-miR-21-5p FOXP2 1.51084295924322 1.54551622173259e-34 -3.24994941369723 1.71142859920958e-14 mirMAP -0.735827260635865 3.46535182735824e-06 NA NA NA hsa-miR-222-3p FPGS 1.08574156066353 1.76407192348131e-11 -0.400194996205355 0.000137927988021499 miRNAWalker2_validate -0.115876526810136 0.000184078101145263 NA NA NA hsa-miR-455-5p FPR3 -0.270546034117157 0.0581320703577731 -1.13174340821664 5.45854896925606e-09 miRanda -0.357091375143381 9.0942769035691e-08 NA NA NA hsa-miR-29c-3p FRAS1 -1.4367517608807 1.61767774905781e-21 -0.924871924759696 0.0331586871598162 miRNATAP -0.687746566795409 2.0040652004388e-07 NA NA NA hsa-miR-29c-3p FRAT2 -1.4367517608807 1.61767774905781e-21 0.225546147167742 0.0512402780577874 miRNATAP -0.195012447145813 2.66822962952396e-08 NA NA NA hsa-miR-21-5p FREM2 1.51084295924322 1.54551622173259e-34 -5.80688485224769 4.9991869723566e-26 mirMAP -1.22416237431968 6.30716303810603e-09 NA NA NA hsa-miR-34a-5p FRK 1.03694231790865 5.74864019540594e-14 -0.582697382356121 0.000322296032876141 MirTarget -0.158615523387099 0.00456683464890771 NA NA NA hsa-miR-21-5p FRMD3 1.51084295924322 1.54551622173259e-34 0.199205669298484 0.521900499692411 MirTarget -0.384481377544254 0.000675378904605147 NA NA NA hsa-miR-34a-5p FRMD4A 1.03694231790865 5.74864019540594e-14 -0.295942667178682 0.0369259224949523 MirTarget -0.195515624420368 5.45315160519035e-05 NA NA NA hsa-miR-146b-5p FRMD6 0.419719546795449 0.0457375823220155 -1.21152640864769 5.47511255884304e-11 MirTarget;miRanda -0.110382424384038 0.0118805220930802 NA NA NA hsa-miR-20a-5p FRMD6 0.854326758727003 5.04256669663285e-07 -1.21152640864769 5.47511255884304e-11 MirTarget;miRNATAP -0.279756250197403 1.25931771546973e-07 NA NA NA hsa-miR-132-3p FRY 0.323796239695997 0.00272093067935091 -0.425459175801124 0.00295852647768929 miRNAWalker2_validate -0.138666253938917 0.0334264217593433 NA NA NA hsa-miR-15a-5p FRYL 0.349521211668244 0.000770735998804736 0.0143478174315508 0.866552629535314 miRNATAP -0.12420156514006 0.00186683449316967 NA NA NA hsa-miR-30e-5p FRZB -0.627815042856657 3.02205690184908e-10 0.701009968619498 0.000998580207648309 MirTarget -0.393803982802311 0.000131701385319284 NA NA NA hsa-miR-455-5p FRZB -0.270546034117157 0.0581320703577731 0.701009968619498 0.000998580207648309 miRanda -0.183378199077313 0.0123996843335769 NA NA NA hsa-miR-17-3p FSCN1 0.410352776142368 0.00422200500748636 -0.0511343247270117 0.741400658089115 miRNAWalker2_validate -0.103356105069568 0.0496798432437257 NA NA NA hsa-miR-455-5p FSD1L -0.270546034117157 0.0581320703577731 0.800482039865012 2.61274557191708e-06 miRanda -0.118675291707921 0.0446067530748059 NA NA NA hsa-miR-455-5p FSTL1 -0.270546034117157 0.0581320703577731 -0.53295806881748 0.00292082806371731 miRanda -0.299441858184359 8.81757042017881e-07 NA NA NA hsa-miR-17-3p FTO 0.410352776142368 0.00422200500748636 -0.232812028117052 0.00922973083936813 mirMAP -0.18286596195913 8.56691079946457e-10 NA NA NA hsa-miR-20a-5p FTO 0.854326758727003 5.04256669663285e-07 -0.232812028117052 0.00922973083936813 mirMAP -0.167029963182185 1.43329087776647e-11 NA NA NA hsa-miR-30b-5p FTO -0.54056186708617 2.44688760798341e-05 -0.232812028117052 0.00922973083936813 mirMAP -0.127255174035186 0.000159717964351959 NA NA NA hsa-miR-132-3p FUBP3 0.323796239695997 0.00272093067935091 -0.384319652438786 4.56520872825586e-06 miRNATAP -0.14899420753484 9.14049624426903e-05 NA NA NA hsa-miR-192-5p FUT11 -0.50188499512787 0.00344713341196035 -0.315279657472101 0.0136223466695405 miRNAWalker2_validate -0.127162726232481 0.000433381025657782 NA NA NA hsa-miR-455-5p FUT11 -0.270546034117157 0.0581320703577731 -0.315279657472101 0.0136223466695405 miRanda -0.118102120726261 0.00698532223106178 NA NA NA hsa-miR-30e-5p FUT4 -0.627815042856657 3.02205690184908e-10 -0.446193249796337 0.0576043872013691 mirMAP -0.332662945576996 0.00339925052547806 NA NA NA hsa-miR-455-3p FUT4 -1.3998033821095 5.72010709806871e-17 -0.446193249796337 0.0576043872013691 mirMAP -0.214334177019673 0.00113575672916969 NA NA NA hsa-miR-34a-5p FUT8 1.03694231790865 5.74864019540594e-14 -0.357579793987703 0.0591834336766341 miRNATAP -0.321732587646362 5.9278910602786e-07 27533464 Furthermore using microRNA array we identified FUT8 as one of the miR-26a miR-34a and miR-146a-targeted genes liver cancer hsa-miR-221-3p FXN 1.12244756358612 3.48370308238012e-13 -1.37523749344236 9.95432558430183e-29 MirTarget -0.155802968185431 0.000122146660224215 NA NA NA hsa-miR-222-3p FXN 1.08574156066353 1.76407192348131e-11 -1.37523749344236 9.95432558430183e-29 MirTarget -0.204854609465653 1.1175572103948e-07 NA NA NA hsa-miR-34a-5p FXYD2 1.03694231790865 5.74864019540594e-14 -2.26013496213811 0.000355902741187264 MirTarget -1.08885360584032 4.93728399010152e-07 NA NA NA hsa-miR-17-3p FXYD6 0.410352776142368 0.00422200500748636 -1.0291947907352 1.04928876518021e-09 MirTarget -0.178842734884673 0.0022043244050567 NA NA NA hsa-miR-19b-3p FYCO1 0.601279551368824 0.00016685097085251 -0.0148324387984431 0.883365385401447 miRNAWalker2_validate -0.196328494910908 5.41368342871275e-11 NA NA NA hsa-miR-20a-5p FYCO1 0.854326758727003 5.04256669663285e-07 -0.0148324387984431 0.883365385401447 MirTarget -0.187319599335118 1.83690964964603e-11 NA NA NA hsa-miR-30b-5p FYCO1 -0.54056186708617 2.44688760798341e-05 -0.0148324387984431 0.883365385401447 MirTarget;miRNATAP -0.112533164627685 0.00315510979841312 NA NA NA hsa-miR-20a-5p FYN 0.854326758727003 5.04256669663285e-07 -1.05543942235431 1.10191754676925e-15 miRNATAP -0.231854719621814 1.0029459490739e-09 NA NA NA hsa-miR-146b-5p FZD1 0.419719546795449 0.0457375823220155 -0.990655512447529 2.10933438723933e-07 MirTarget;PITA;miRanda -0.181547752240403 4.76064172222519e-05 NA NA NA hsa-miR-192-5p FZD1 -0.50188499512787 0.00344713341196035 -0.990655512447529 2.10933438723933e-07 miRNAWalker2_validate -0.45834591686859 3.50571643482894e-18 NA NA NA hsa-miR-15a-5p FZD10 0.349521211668244 0.000770735998804736 1.18521144835282 0.000162683525329498 miRNATAP -0.438409856444815 0.003263536270437 NA NA NA hsa-miR-455-3p FZD10 -1.3998033821095 5.72010709806871e-17 1.18521144835282 0.000162683525329498 PITA;miRNATAP -0.56334164531716 9.62780657403636e-11 NA NA NA hsa-miR-194-5p FZD3 -0.292530160992458 0.0996141384876663 -0.431602727356764 0.0760494397449049 miRNATAP -0.163368946568916 0.0146280231481158 NA NA NA hsa-miR-19b-3p FZD3 0.601279551368824 0.00016685097085251 -0.431602727356764 0.0760494397449049 mirMAP -0.24031433694887 0.00112634324256369 NA NA NA hsa-miR-20a-5p FZD3 0.854326758727003 5.04256669663285e-07 -0.431602727356764 0.0760494397449049 MirTarget;mirMAP;miRNATAP -0.263395197675831 0.000124585706310954 NA NA NA hsa-miR-30e-5p FZD3 -0.627815042856657 3.02205690184908e-10 -0.431602727356764 0.0760494397449049 MirTarget -0.313017658821363 0.00780190229296611 NA NA NA hsa-miR-132-3p FZD4 0.323796239695997 0.00272093067935091 -0.346477770504521 0.0109747315056824 mirMAP -0.197762210860301 0.00135588231940112 NA NA NA hsa-miR-17-3p FZD4 0.410352776142368 0.00422200500748636 -0.346477770504521 0.0109747315056824 MirTarget -0.252002356659912 3.55104649644788e-08 NA NA NA hsa-miR-20a-5p FZD4 0.854326758727003 5.04256669663285e-07 -0.346477770504521 0.0109747315056824 miRNATAP -0.232364507622619 9.13182947842467e-10 NA NA NA hsa-miR-21-5p FZD4 1.51084295924322 1.54551622173259e-34 -0.346477770504521 0.0109747315056824 mirMAP -0.321725677881532 3.91700387140416e-11 NA NA NA hsa-miR-194-5p FZD6 -0.292530160992458 0.0996141384876663 0.589500198001939 0.00374127878510925 MirTarget -0.265420163621645 1.75074747054336e-06 NA NA NA hsa-miR-455-5p FZD6 -0.270546034117157 0.0581320703577731 0.589500198001939 0.00374127878510925 miRanda -0.230555626016252 0.000940179578305785 NA NA NA hsa-miR-192-5p FZD7 -0.50188499512787 0.00344713341196035 -0.284533887049024 0.256557978536031 miRNAWalker2_validate -0.59446912784293 2.96084223842181e-18 NA NA NA hsa-miR-215-5p FZD7 -0.981544773246509 3.14452272477156e-05 -0.284533887049024 0.256557978536031 miRNAWalker2_validate -0.176488344117398 0.00056453629652869 NA NA NA hsa-miR-192-5p FZD9 -0.50188499512787 0.00344713341196035 -0.243785341556497 0.505341223526538 miRNATAP -0.306354280194544 0.00309846297489247 NA NA NA hsa-miR-19b-3p G0S2 0.601279551368824 0.00016685097085251 -2.07670656507786 2.38871174750404e-11 MirTarget -0.212991077426063 0.0280929183133112 NA NA NA hsa-miR-19b-3p G3BP2 0.601279551368824 0.00016685097085251 -0.452515291133634 1.38574303203514e-07 MirTarget;miRNATAP -0.110929069591502 2.31628639231025e-05 NA NA NA hsa-miR-132-3p GAB1 0.323796239695997 0.00272093067935091 -0.316010954422049 0.00456197149339329 mirMAP -0.156184858478685 0.00198393470110477 NA NA NA hsa-miR-221-3p GAB1 1.12244756358612 3.48370308238012e-13 -0.316010954422049 0.00456197149339329 MirTarget;miRNATAP -0.141495019686334 3.2987590560242e-05 NA NA NA hsa-miR-222-3p GAB1 1.08574156066353 1.76407192348131e-11 -0.316010954422049 0.00456197149339329 MirTarget;miRNATAP -0.113511940450049 0.000539576846072762 NA NA NA hsa-miR-34a-5p GAB1 1.03694231790865 5.74864019540594e-14 -0.316010954422049 0.00456197149339329 MirTarget -0.104287091677839 0.00647406484540799 NA NA NA hsa-miR-455-5p GAB3 -0.270546034117157 0.0581320703577731 -0.338940644345141 0.0197446260921705 miRanda -0.229721358041004 3.30431274395092e-06 NA NA NA hsa-miR-15a-5p GABPA 0.349521211668244 0.000770735998804736 -0.40218657317038 1.30713108764544e-06 MirTarget -0.104052630974366 0.00838615485077287 NA NA NA hsa-miR-30c-5p GABPB2 -0.432111642767632 0.000159764714931007 0.8104559893402 3.81209247158567e-10 mirMAP -0.12677887446343 0.0244586182590493 NA NA NA hsa-miR-30e-5p GABPB2 -0.627815042856657 3.02205690184908e-10 0.8104559893402 3.81209247158567e-10 mirMAP -0.156175269721837 0.0145103122329633 NA NA NA hsa-miR-455-3p GABPB2 -1.3998033821095 5.72010709806871e-17 0.8104559893402 3.81209247158567e-10 PITA -0.139984946024544 0.000148935786302527 NA NA NA hsa-miR-30e-5p GABRA2 -0.627815042856657 3.02205690184908e-10 0.509413168038816 0.19598617670863 mirMAP -0.728214581543953 0.000122168342221611 NA NA NA hsa-miR-194-5p GABRB3 -0.292530160992458 0.0996141384876663 -4.16765140959954 2.31842522891125e-14 mirMAP;miRNATAP -0.552116123949939 0.000355805899784592 NA NA NA hsa-miR-455-5p GABRB3 -0.270546034117157 0.0581320703577731 -4.16765140959954 2.31842522891125e-14 miRNATAP -0.475196167894017 0.0140541746988542 NA NA NA hsa-miR-455-5p GAD1 -0.270546034117157 0.0581320703577731 2.23136701042023 1.0226624349735e-07 miRanda -0.748677882575226 2.05199689506122e-07 NA NA NA hsa-miR-127-3p GADD45G -1.0751374948053 2.19322892330221e-05 -1.8078339802055 7.96436141465682e-13 miRanda;miRNATAP -0.127395391416082 0.010086377064882 NA NA NA hsa-miR-181a-5p GADD45G 0.250113435902954 0.0551933249319293 -1.8078339802055 7.96436141465682e-13 miRNAWalker2_validate -0.541338211358986 1.77478587318898e-08 NA NA NA hsa-miR-455-5p GAL3ST4 -0.270546034117157 0.0581320703577731 0.631223797822951 0.00488098364080145 miRanda -0.476086248330396 2.95947552275996e-10 NA NA NA hsa-miR-30b-5p GALNT1 -0.54056186708617 2.44688760798341e-05 0.0414221776323931 0.654635129472205 MirTarget -0.151565359751484 1.23632353654397e-05 NA NA NA hsa-miR-17-3p GALNT10 0.410352776142368 0.00422200500748636 0.831350337705815 6.36030803570338e-11 mirMAP -0.163490808762553 0.00020581515394356 NA NA NA hsa-miR-455-5p GALNT10 -0.270546034117157 0.0581320703577731 0.831350337705815 6.36030803570338e-11 miRanda -0.324771525257047 6.05437913151651e-14 NA NA NA hsa-miR-192-5p GALNT12 -0.50188499512787 0.00344713341196035 -0.63804508821255 0.043770525430056 miRNAWalker2_validate -0.393099848798327 1.04134877468359e-05 NA NA NA hsa-miR-15a-5p GALNT7 0.349521211668244 0.000770735998804736 -0.27652761191448 0.222052571963854 MirTarget -0.38933439467797 0.000247131582215264 NA NA NA hsa-miR-194-5p GALNT7 -0.292530160992458 0.0996141384876663 -0.27652761191448 0.222052571963854 MirTarget -0.546211681859789 3.75062238548324e-20 NA NA NA hsa-miR-27b-3p GALNT7 -0.823491817819754 9.20935302746823e-14 -0.27652761191448 0.222052571963854 MirTarget;miRNATAP -0.405362308033425 2.87854634577228e-05 NA NA NA hsa-miR-34a-5p GALNT7 1.03694231790865 5.74864019540594e-14 -0.27652761191448 0.222052571963854 MirTarget;miRNATAP -0.318127971298515 3.85104721291527e-05 NA NA NA hsa-miR-455-3p GALNT7 -1.3998033821095 5.72010709806871e-17 -0.27652761191448 0.222052571963854 miRNATAP -0.432137588804442 3.08526572121776e-12 NA NA NA hsa-miR-181a-5p GAN 0.250113435902954 0.0551933249319293 -0.684958975626295 2.31241918352254e-08 mirMAP -0.190371742615427 4.17014215638235e-05 NA NA NA hsa-miR-181b-5p GAN 0.488256489401108 0.00105321129419701 -0.684958975626295 2.31241918352254e-08 mirMAP -0.163207435435014 5.40283380623868e-05 NA NA NA hsa-miR-181a-5p GANC 0.250113435902954 0.0551933249319293 -0.013778864336826 0.89063946497633 MirTarget -0.130283353555182 0.000482828329604642 NA NA NA hsa-miR-181b-5p GANC 0.488256489401108 0.00105321129419701 -0.013778864336826 0.89063946497633 MirTarget -0.154552846068202 1.66569752708126e-06 NA NA NA hsa-miR-29c-3p GAPDH -1.4367517608807 1.61767774905781e-21 0.480767917732015 7.88084504602343e-05 miRNAWalker2_validate -0.113898460562926 0.00249189997397085 NA NA NA hsa-miR-146b-5p GARNL3 0.419719546795449 0.0457375823220155 -0.93670235449509 5.40638240148627e-05 miRanda -0.282248469831158 1.37296235200074e-07 NA NA NA hsa-miR-148a-3p GAS1 -0.748702855596996 3.93313343865641e-07 -2.01123836877249 1.00269358999977e-12 miRNAWalker2_validate -0.446935540677881 1.98427341642504e-06 NA NA NA hsa-miR-34a-5p GAS1 1.03694231790865 5.74864019540594e-14 -2.01123836877249 1.00269358999977e-12 miRNAWalker2_validate;miRNATAP -0.40385806079271 4.64900181940774e-05 24220341 MiR 34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K/Akt/Bad pathway; Both miR-34a and GAS1 are frequently down-regulated in various tumors; However it has been reported that while GAS1 is down-regulated in papillary thyroid carcinoma PTC miR-34a is up-regulated in this specific type of cancer although their potential roles in PTC tumorigenesis have not been examined to date; A computational search revealed that miR-34a putatively binds to the 3'-UTR of GAS1 gene; In the present study we confirmed previous findings that miR-34a is up-regulated and GAS1 down-regulated in PTC tissues; Further studies indicated that GAS1 is directly targeted by miR-34a; Silencing of GAS1 had similar growth-promoting effects as overexpression of miR-34a; Taken together our results demonstrate that miR-34a regulates GAS1 expression to promote proliferation and suppress apoptosis in PTC cells via PI3K/Akt/Bad pathway tumorigenesis thyroid cancer hsa-miR-194-5p GAS7 -0.292530160992458 0.0996141384876663 -0.0839516177440096 0.676022872611456 mirMAP -0.512821199967693 1.05020086638116e-22 NA NA NA hsa-miR-34a-5p GATA3 1.03694231790865 5.74864019540594e-14 -1.71321917243751 7.94731206842048e-12 MirTarget -0.551678107083525 1.88353117362784e-10 NA NA NA hsa-miR-34a-5p GATA4 1.03694231790865 5.74864019540594e-14 -0.822427101935285 5.67287828795947e-10 miRNAWalker2_validate -0.271175676872862 3.00452143229167e-09 NA NA NA hsa-miR-20a-5p GATA6 0.854326758727003 5.04256669663285e-07 -1.09329244365753 9.73202176150752e-11 miRNAWalker2_validate -0.182406476921655 0.0001839014146683 NA NA NA hsa-miR-194-5p GATAD2A -0.292530160992458 0.0996141384876663 -0.0527608054512365 0.435650190910679 mirMAP -0.109733802240223 1.37223088173121e-09 NA NA NA hsa-miR-181a-5p GATM 0.250113435902954 0.0551933249319293 -1.67872610104551 6.33871234809562e-13 MirTarget -0.37517733801518 2.83813089158717e-05 NA NA NA hsa-miR-181b-5p GATM 0.488256489401108 0.00105321129419701 -1.67872610104551 6.33871234809562e-13 MirTarget -0.45193088677117 4.77628229854381e-09 NA NA NA hsa-miR-455-3p GBAS -1.3998033821095 5.72010709806871e-17 0.626397510758599 2.56186532075617e-08 MirTarget -0.234793631411575 4.37698651039279e-14 NA NA NA hsa-miR-455-5p GBGT1 -0.270546034117157 0.0581320703577731 0.219571826225104 0.180863707276777 miRanda -0.266576550788535 1.62970153806543e-06 NA NA NA hsa-miR-20a-5p GBP4 0.854326758727003 5.04256669663285e-07 -0.650160615796805 0.000187737985372556 mirMAP -0.278560661052495 1.21269341759649e-08 NA NA NA hsa-miR-34a-5p GBP5 1.03694231790865 5.74864019540594e-14 -0.694499142260316 0.0141117083551714 MirTarget -0.28544451898768 0.0033627830356517 NA NA NA hsa-miR-20a-5p GCA 0.854326758727003 5.04256669663285e-07 -0.56871649988492 0.000267567519146868 MirTarget -0.137354807188299 0.00197386476031777 NA NA NA hsa-miR-19b-3p GCLM 0.601279551368824 0.00016685097085251 -0.490472345051649 0.00239558983173471 mirMAP -0.152443255340606 0.00192975165900659 NA NA NA hsa-miR-20a-5p GCLM 0.854326758727003 5.04256669663285e-07 -0.490472345051649 0.00239558983173471 mirMAP -0.142887688343017 0.00182984460395035 NA NA NA hsa-miR-20b-5p GCLM 0.457668023910379 0.0285865211936156 -0.490472345051649 0.00239558983173471 mirMAP -0.115473902434174 0.00218589698150978 NA NA NA hsa-miR-146b-5p GCNT4 0.419719546795449 0.0457375823220155 -0.356605715930898 0.144778964659476 miRanda -0.125815955058604 0.0266527296947288 NA NA NA hsa-miR-20a-5p GCNT4 0.854326758727003 5.04256669663285e-07 -0.356605715930898 0.144778964659476 MirTarget -0.306926373858422 8.02814582313197e-06 NA NA NA hsa-miR-146b-5p GCOM1 0.419719546795449 0.0457375823220155 -1.46306485629338 6.80693033828188e-11 miRanda -0.153401168989898 0.00392863764220298 NA NA NA hsa-miR-17-3p GCOM1 0.410352776142368 0.00422200500748636 -1.46306485629338 6.80693033828188e-11 MirTarget -0.228437043496933 0.00339950720273575 NA NA NA hsa-miR-181a-5p GDA 0.250113435902954 0.0551933249319293 -1.84723490700582 3.83899286012136e-06 miRNATAP -0.46981661764564 0.00194212890772798 NA NA NA hsa-miR-181b-5p GDA 0.488256489401108 0.00105321129419701 -1.84723490700582 3.83899286012136e-06 miRNATAP -0.3929900712458 0.00289508616497044 NA NA NA hsa-miR-148a-3p GDF6 -0.748702855596996 3.93313343865641e-07 -2.10139054692363 1.01669881798518e-11 miRNATAP -0.327974606729441 0.00151705432220982 NA NA NA hsa-miR-224-3p GDF7 1.40770116795301 1.31426607144612e-08 -1.70565631034897 1.45352939577227e-07 mirMAP -0.33032138163421 2.19235580868161e-07 NA NA NA hsa-miR-192-5p GDPD5 -0.50188499512787 0.00344713341196035 0.0440112951343092 0.780082492291835 mirMAP -0.237511551530035 6.771421543163e-08 NA NA NA hsa-miR-224-3p GEM 1.40770116795301 1.31426607144612e-08 -1.33419875801541 8.85114971471045e-07 MirTarget -0.142917036291866 0.00795564313541513 NA NA NA hsa-miR-132-3p GFOD1 0.323796239695997 0.00272093067935091 -0.739136473829968 1.54144336609472e-06 mirMAP -0.290306155416435 3.47794203380233e-05 NA NA NA hsa-miR-181b-5p GFOD1 0.488256489401108 0.00105321129419701 -0.739136473829968 1.54144336609472e-06 mirMAP -0.388676785260715 2.61455745827552e-15 NA NA NA hsa-miR-182-5p GFOD1 1.96601340710222 4.39326175603633e-09 -0.739136473829968 1.54144336609472e-06 mirMAP -0.114391248424087 1.77586434116472e-07 NA NA NA hsa-miR-19b-3p GFOD1 0.601279551368824 0.00016685097085251 -0.739136473829968 1.54144336609472e-06 miRNAWalker2_validate -0.103448387499686 0.0288215389309219 NA NA NA hsa-miR-21-5p GFOD1 1.51084295924322 1.54551622173259e-34 -0.739136473829968 1.54144336609472e-06 mirMAP -0.365376621578094 4.83300398323549e-11 NA NA NA hsa-miR-34a-5p GFPT1 1.03694231790865 5.74864019540594e-14 0.100055458679413 0.277499200932347 miRNAWalker2_validate -0.116543479569087 0.000204169155238568 NA NA NA hsa-miR-30e-5p GFPT2 -0.627815042856657 3.02205690184908e-10 -1.12444193256749 0.00225668167232903 MirTarget -0.902611096792059 3.27936759700206e-07 NA NA NA hsa-miR-132-3p GFRA1 0.323796239695997 0.00272093067935091 -2.5486406119615 2.43457108723549e-08 mirMAP -0.98174829427871 2.63531404902569e-06 NA NA NA hsa-miR-17-3p GFRA1 0.410352776142368 0.00422200500748636 -2.5486406119615 2.43457108723549e-08 miRNATAP -0.394774437563572 0.0125581220939068 NA NA NA hsa-miR-181a-5p GFRA1 0.250113435902954 0.0551933249319293 -2.5486406119615 2.43457108723549e-08 mirMAP -0.606201601956751 0.000493974206522243 NA NA NA hsa-miR-181b-5p GFRA1 0.488256489401108 0.00105321129419701 -2.5486406119615 2.43457108723549e-08 mirMAP -0.891805619611309 2.29624707713787e-09 NA NA NA hsa-miR-20a-5p GFRA1 0.854326758727003 5.04256669663285e-07 -2.5486406119615 2.43457108723549e-08 mirMAP -0.422901475150633 0.00129882390540228 NA NA NA hsa-miR-409-3p GFRA1 -0.499649792570937 0.0526751181520117 -2.5486406119615 2.43457108723549e-08 mirMAP -0.291970368600025 0.000851592004116005 NA NA NA hsa-miR-432-5p GFRA1 -0.536178819038888 0.0748623258271085 -2.5486406119615 2.43457108723549e-08 mirMAP -0.287448296446267 0.000130090109449751 NA NA NA hsa-miR-214-5p GGA3 -1.91497809567701 3.92955595018147e-12 0.711679336404982 1.46861146142528e-21 MirTarget -0.1090792042414 9.77952627620365e-17 NA NA NA hsa-miR-181a-5p GHITM 0.250113435902954 0.0551933249319293 -0.677442442991533 3.66188296517632e-14 MirTarget;miRNATAP -0.235785640072167 2.64564070489522e-12 NA NA NA hsa-miR-181b-5p GHITM 0.488256489401108 0.00105321129419701 -0.677442442991533 3.66188296517632e-14 MirTarget;miRNATAP -0.242226297113184 6.06744366083344e-17 NA NA NA hsa-miR-15a-5p GHR 0.349521211668244 0.000770735998804736 -3.0731350188505 2.37156410493146e-28 MirTarget;miRNATAP -0.550186371213254 8.39585599580478e-05 NA NA NA hsa-miR-409-3p GHR -0.499649792570937 0.0526751181520117 -3.0731350188505 2.37156410493146e-28 PITA -0.116898392522362 0.0382340380022587 NA NA NA hsa-miR-19b-3p GIMAP6 0.601279551368824 0.00016685097085251 -0.664782195381983 1.03600938605496e-05 mirMAP -0.190720661955606 3.30615530927815e-05 NA NA NA hsa-miR-455-5p GIPR -0.270546034117157 0.0581320703577731 0.407371186018338 0.173011672305006 miRanda -0.382994859086437 0.000171885640775716 NA NA NA hsa-miR-505-5p GIT1 -0.768282569967001 1.14662846595407e-05 0.949279055711163 7.51097379368972e-25 miRNATAP -0.125685903592614 2.53671874991949e-06 NA NA NA hsa-miR-19b-3p GJA1 0.601279551368824 0.00016685097085251 0.506352390170207 0.00155115110748353 MirTarget;miRNATAP -0.150005836493063 0.00207536126151614 NA NA NA hsa-miR-30e-5p GJA1 -0.627815042856657 3.02205690184908e-10 0.506352390170207 0.00155115110748353 MirTarget -0.166795386967395 0.0319084774333872 NA NA NA hsa-miR-455-5p GJA1 -0.270546034117157 0.0581320703577731 0.506352390170207 0.00155115110748353 miRanda -0.208190142876 0.000143167014644293 NA NA NA hsa-miR-455-5p GJC1 -0.270546034117157 0.0581320703577731 2.11387274477961 2.08606725531307e-29 miRNATAP -0.269306997829449 8.97259318992943e-05 NA NA NA hsa-miR-132-3p GK 0.323796239695997 0.00272093067935091 -0.932721298936469 1.60339764790756e-07 miRNAWalker2_validate -0.163902678484077 0.0457381883077154 NA NA NA hsa-miR-146b-5p GLCCI1 0.419719546795449 0.0457375823220155 -0.285824127662563 0.0400950675736783 miRanda -0.10793203097942 0.000800844277397635 NA NA NA hsa-miR-21-5p GLCCI1 1.51084295924322 1.54551622173259e-34 -0.285824127662563 0.0400950675736783 miRNAWalker2_validate;MirTarget;miRNATAP -0.421184063560818 6.28784287543577e-18 NA NA NA hsa-miR-30b-5p GLCCI1 -0.54056186708617 2.44688760798341e-05 -0.285824127662563 0.0400950675736783 MirTarget;miRNATAP -0.148466475412248 0.00488029372010658 NA NA NA hsa-miR-455-5p GLDN -0.270546034117157 0.0581320703577731 1.85654071848598 4.54699264502673e-06 miRanda -0.276965492916746 0.048755489254077 NA NA NA hsa-miR-30e-5p GLI2 -0.627815042856657 3.02205690184908e-10 -1.14224882795575 0.000293659575288629 MirTarget -0.335253702287179 0.0291902300993384 NA NA NA hsa-miR-19b-3p GLIPR1 0.601279551368824 0.00016685097085251 -0.210856741137956 0.266406837563875 mirMAP -0.216604798024406 0.000157872510109536 NA NA NA hsa-miR-148a-3p GLIPR2 -0.748702855596996 3.93313343865641e-07 -0.261246364993241 0.126523092005897 MirTarget -0.572861369908527 5.79843097207256e-28 NA NA NA hsa-miR-455-5p GLIPR2 -0.270546034117157 0.0581320703577731 -0.261246364993241 0.126523092005897 miRanda -0.201657610740122 0.000547026161967144 NA NA NA hsa-miR-29c-3p GLIS2 -1.4367517608807 1.61767774905781e-21 0.562379009835414 0.0131617515622673 MirTarget;miRNATAP -0.280755802825285 5.46288958347257e-05 NA NA NA hsa-miR-34a-5p GLIS2 1.03694231790865 5.74864019540594e-14 0.562379009835414 0.0131617515622673 MirTarget -0.214153461528152 0.00608239567078316 NA NA NA hsa-miR-505-5p GLIS2 -0.768282569967001 1.14662846595407e-05 0.562379009835414 0.0131617515622673 MirTarget;miRNATAP -0.169442964549644 0.0069143245315341 NA NA NA hsa-miR-146b-5p GLIS3 0.419719546795449 0.0457375823220155 -0.851275924384664 0.000690675817272366 mirMAP -0.240936756953196 3.40190008895225e-05 NA NA NA hsa-miR-194-5p GLIS3 -0.292530160992458 0.0996141384876663 -0.851275924384664 0.000690675817272366 miRNATAP -0.454433989381706 1.99393112976169e-11 NA NA NA hsa-miR-20a-5p GLIS3 0.854326758727003 5.04256669663285e-07 -0.851275924384664 0.000690675817272366 miRNATAP -0.214941628315687 0.00260441279292911 NA NA NA hsa-miR-455-5p GLIS3 -0.270546034117157 0.0581320703577731 -0.851275924384664 0.000690675817272366 miRanda;miRNATAP -0.178500049342836 0.0391191600703628 NA NA NA hsa-miR-222-3p GLRX5 1.08574156066353 1.76407192348131e-11 -0.363361894214886 0.000526673125748046 miRNAWalker2_validate -0.151507107555683 7.9775321818949e-07 NA NA NA hsa-miR-455-5p GLS -0.270546034117157 0.0581320703577731 0.643014343434453 0.00121456577515448 miRanda -0.209603787287599 0.00213855273128523 NA NA NA hsa-miR-21-5p GLYR1 1.51084295924322 1.54551622173259e-34 -0.173595165539688 0.0275427557335278 miRNATAP -0.104856851434877 0.000236785879216891 NA NA NA hsa-miR-221-3p GLYR1 1.12244756358612 3.48370308238012e-13 -0.173595165539688 0.0275427557335278 miRNAWalker2_validate -0.10587081673189 9.80351392221864e-06 NA NA NA hsa-miR-30e-5p GMEB2 -0.627815042856657 3.02205690184908e-10 0.649674999709834 6.33331854886269e-19 MirTarget;miRNATAP -0.142882137235087 9.35981475846132e-05 NA NA NA hsa-miR-20a-5p GMPR 0.854326758727003 5.04256669663285e-07 -1.37298834189273 5.25559220935139e-06 miRNATAP -0.539895461182833 1.80876695530484e-10 NA NA NA hsa-miR-20a-5p GNA11 0.854326758727003 5.04256669663285e-07 -0.43119317908096 0.0174252610152971 mirMAP -0.123588186907321 0.0164045494778984 NA NA NA hsa-miR-19b-3p GNAI1 0.601279551368824 0.00016685097085251 0.100317624945054 0.491109257796602 miRNATAP -0.163727723392821 0.000197206431996122 NA NA NA hsa-miR-99a-5p GNAL -1.51481656384839 3.93230057259529e-14 1.33283669629593 1.09261153741281e-06 miRNAWalker2_validate -0.245978046135723 0.000154729679883613 NA NA NA hsa-miR-15a-5p GNAO1 0.349521211668244 0.000770735998804736 -3.67315176204714 3.1674815504488e-21 mirMAP -0.510322888453748 0.00807770639470999 NA NA NA hsa-miR-34a-5p GNAO1 1.03694231790865 5.74864019540594e-14 -3.67315176204714 3.1674815504488e-21 mirMAP -0.342207593088554 0.0149091128426452 NA NA NA hsa-miR-21-5p GNAQ 1.51084295924322 1.54551622173259e-34 -0.387863258052234 5.35620148383708e-06 miRNAWalker2_validate -0.246469163664991 3.51832080720891e-16 NA NA NA hsa-miR-27b-3p GNAZ -0.823491817819754 9.20935302746823e-14 2.76868512062906 9.54719404168263e-18 miRNATAP -0.643004767308374 7.91738782998592e-06 NA NA NA hsa-miR-455-5p GNB1 -0.270546034117157 0.0581320703577731 0.0958557110185971 0.13435411812339 miRanda -0.105145596215111 1.02847761734852e-06 NA NA NA hsa-miR-27b-3p GNB1L -0.823491817819754 9.20935302746823e-14 0.972387895486426 1.58066300637692e-14 mirMAP -0.179444012670643 0.0014106931612724 NA NA NA hsa-miR-20a-5p GNE 0.854326758727003 5.04256669663285e-07 -1.82350791069008 3.50187061744317e-25 mirMAP -0.281912030681587 6.94970927305595e-08 NA NA NA hsa-miR-20b-5p GNE 0.457668023910379 0.0285865211936156 -1.82350791069008 3.50187061744317e-25 mirMAP -0.104949837366907 0.016004438205913 NA NA NA hsa-miR-21-5p GNE 1.51084295924322 1.54551622173259e-34 -1.82350791069008 3.50187061744317e-25 miRNAWalker2_validate -0.756130062299966 3.40005906023502e-33 NA NA NA hsa-miR-409-3p GNE -0.499649792570937 0.0526751181520117 -1.82350791069008 3.50187061744317e-25 mirMAP -0.101593824870095 0.00395359492007512 NA NA NA hsa-miR-455-5p GNG12 -0.270546034117157 0.0581320703577731 -0.749024820971969 9.12787292602269e-08 miRanda -0.226520595073207 2.68617949312973e-06 NA NA NA hsa-miR-455-5p GNG2 -0.270546034117157 0.0581320703577731 -0.850794425511732 6.29859635775606e-10 miRanda -0.229407106619483 1.4480956300012e-06 NA NA NA hsa-miR-30e-5p GNPDA1 -0.627815042856657 3.02205690184908e-10 0.61028061251221 1.71578885600492e-08 MirTarget -0.359614835530671 3.96725094666189e-12 NA NA NA hsa-miR-20b-5p GNPNAT1 0.457668023910379 0.0285865211936156 -1.09215565280503 1.05388399592452e-20 mirMAP -0.113090822188322 7.01584602390206e-05 NA NA NA hsa-miR-455-5p GNPTAB -0.270546034117157 0.0581320703577731 0.205062389983289 0.0358881440504973 miRanda -0.100843660282505 0.00250140904520302 NA NA NA hsa-miR-192-5p GNRH1 -0.50188499512787 0.00344713341196035 0.981716836590702 6.04257350059458e-10 miRNAWalker2_validate -0.270554653117322 2.01527772341779e-09 NA NA NA hsa-miR-215-5p GNRH1 -0.981544773246509 3.14452272477156e-05 0.981716836590702 6.04257350059458e-10 miRNAWalker2_validate -0.161476493739635 8.65762518452015e-07 NA NA NA hsa-miR-27b-3p GNS -0.823491817819754 9.20935302746823e-14 0.326695508721711 3.76363852828077e-05 miRNATAP -0.216252562474521 1.1919492170072e-10 NA NA NA hsa-miR-181a-5p GOLGA1 0.250113435902954 0.0551933249319293 -0.0571328534655402 0.442142749734858 MirTarget;miRNATAP -0.144009801844495 1.41341432522524e-07 NA NA NA hsa-miR-181b-5p GOLGA1 0.488256489401108 0.00105321129419701 -0.0571328534655402 0.442142749734858 MirTarget;miRNATAP -0.139369749492396 4.1072194522484e-09 NA NA NA hsa-miR-99a-5p GOLGA3 -1.51481656384839 3.93230057259529e-14 0.64826667792101 5.34597237166584e-20 miRNAWalker2_validate -0.124441137020491 1.91996399680068e-13 NA NA NA hsa-miR-21-5p GOLGA4 1.51084295924322 1.54551622173259e-34 -0.24392104493269 0.0186334222534644 miRNAWalker2_validate -0.245719613261825 3.01269574706493e-11 NA NA NA hsa-miR-30b-5p GOLGA4 -0.54056186708617 2.44688760798341e-05 -0.24392104493269 0.0186334222534644 MirTarget;miRNATAP -0.157603743673764 5.42996286507815e-05 NA NA NA hsa-miR-19b-3p GOLGA6B 0.601279551368824 0.00016685097085251 -2.45834731979384 1.29136436166878e-09 MirTarget -0.345277489622541 0.00598602065517266 NA NA NA hsa-miR-30b-5p GOLIM4 -0.54056186708617 2.44688760798341e-05 -1.11708238293147 9.94129980037638e-06 mirMAP -0.205862703592831 0.0337672870525632 NA NA NA hsa-miR-27b-3p GOLM1 -0.823491817819754 9.20935302746823e-14 0.88777317418583 0.000185604842755544 MirTarget -0.593984386818351 4.66600227466396e-09 25115396 GOLM1 was directly regulated by miR-27b in PCa cells prostate cancer hsa-miR-146b-5p GOLPH3L 0.419719546795449 0.0457375823220155 0.878975535300631 3.45221988457114e-19 miRanda -0.120518934840362 2.8672958347881e-07 NA NA NA hsa-miR-181a-5p GPAM 0.250113435902954 0.0551933249319293 -0.472844151955403 0.0637965177079971 MirTarget;mirMAP -0.362780025198694 0.000142850929140858 NA NA NA hsa-miR-181b-5p GPAM 0.488256489401108 0.00105321129419701 -0.472844151955403 0.0637965177079971 MirTarget;mirMAP -0.457380185706351 2.59673752509555e-08 NA NA NA hsa-miR-182-5p GPAM 1.96601340710222 4.39326175603633e-09 -0.472844151955403 0.0637965177079971 mirMAP -0.232001614392938 7.43797749226807e-11 NA NA NA hsa-miR-21-5p GPAM 1.51084295924322 1.54551622173259e-34 -0.472844151955403 0.0637965177079971 miRNAWalker2_validate;mirMAP -0.627076677904986 5.37674526051361e-12 NA NA NA hsa-miR-192-5p GPC4 -0.50188499512787 0.00344713341196035 -0.913560136947943 0.0100287848448375 miRNAWalker2_validate -0.741597382018906 3.63224773665996e-14 NA NA NA hsa-miR-34a-5p GPC6 1.03694231790865 5.74864019540594e-14 -0.939350927313324 2.165546640636e-05 MirTarget -0.578012129339349 7.21451095614973e-15 NA NA NA hsa-miR-455-5p GPD1L -0.270546034117157 0.0581320703577731 0.459518744777133 0.00831621590013787 miRanda -0.242281822173838 4.54829965494163e-05 NA NA NA hsa-miR-27b-3p GPD2 -0.823491817819754 9.20935302746823e-14 0.404567318088859 0.000374344403235026 miRNATAP -0.204896504221934 2.7707300006123e-05 NA NA NA hsa-miR-455-3p GPD2 -1.3998033821095 5.72010709806871e-17 0.404567318088859 0.000374344403235026 PITA;miRNATAP -0.150947779787009 1.98189378250437e-06 NA NA NA hsa-miR-455-5p GPD2 -0.270546034117157 0.0581320703577731 0.404567318088859 0.000374344403235026 miRanda -0.199289394199173 2.50479683272724e-07 NA NA NA hsa-miR-221-3p GPM6A 1.12244756358612 3.48370308238012e-13 -4.84536564920804 3.01663369835863e-39 miRNATAP -0.872916127861325 8.87832692814009e-13 NA NA NA hsa-miR-222-3p GPM6A 1.08574156066353 1.76407192348131e-11 -4.84536564920804 3.01663369835863e-39 miRNATAP -0.739885495217361 3.62119317591856e-10 NA NA NA hsa-miR-146b-5p GPM6B 0.419719546795449 0.0457375823220155 -1.05065665616971 2.63522349194003e-07 miRanda -0.102095294746221 0.0336530974474336 NA NA NA hsa-miR-194-5p GPM6B -0.292530160992458 0.0996141384876663 -1.05065665616971 2.63522349194003e-07 miRNATAP -0.512754824777734 2.92617660144082e-21 NA NA NA hsa-miR-455-5p GPNMB -0.270546034117157 0.0581320703577731 -0.0537065419553917 0.803165586875699 miRanda -0.413425438553308 1.21732465794599e-08 NA NA NA hsa-miR-455-5p GPR132 -0.270546034117157 0.0581320703577731 -0.499982362176961 0.0175039742764344 miRanda -0.244659124310977 0.000677970521946792 NA NA NA hsa-miR-19b-3p GPR137B 0.601279551368824 0.00016685097085251 -0.63566282030445 0.00116530639793394 MirTarget;miRNATAP -0.149968518317573 0.0121004764489424 NA NA NA hsa-miR-20a-5p GPR137B 0.854326758727003 5.04256669663285e-07 -0.63566282030445 0.00116530639793394 miRNATAP -0.218862401168965 7.87350981745217e-05 NA NA NA hsa-miR-409-3p GPR155 -0.499649792570937 0.0526751181520117 -0.443288817063763 0.00200052357480386 MirTarget -0.111338085079404 3.71505621992789e-05 NA NA NA hsa-miR-455-5p GPR155 -0.270546034117157 0.0581320703577731 -0.443288817063763 0.00200052357480386 miRanda -0.145553700213409 0.00310867486102766 NA NA NA hsa-miR-146a-5p GPR157 -0.742958238440575 0.000765983177482633 -0.638212778111346 0.00618228794406771 mirMAP -0.106531057101806 0.0382872223236932 NA NA NA hsa-miR-30b-5p GPR157 -0.54056186708617 2.44688760798341e-05 -0.638212778111346 0.00618228794406771 mirMAP -0.210983403790738 0.0173805353166647 NA NA NA hsa-miR-409-3p GPR158 -0.499649792570937 0.0526751181520117 2.23744757647133 4.79988747049009e-07 mirMAP -0.318049839893094 0.000173526830826314 NA NA NA hsa-miR-192-5p GPR19 -0.50188499512787 0.00344713341196035 2.26877210340845 1.58451791616503e-23 miRNAWalker2_validate -0.167328803784092 0.01410253416713 NA NA NA hsa-miR-455-5p GPR85 -0.270546034117157 0.0581320703577731 -0.512745687174905 0.0113337656979268 PITA;miRanda -0.35207695766892 2.97396681015545e-07 NA NA NA hsa-miR-148a-3p GPRC5A -0.748702855596996 3.93313343865641e-07 -1.98790398617405 1.71576224263651e-08 MirTarget -0.64837950530788 2.02612216438666e-08 NA NA NA hsa-miR-20a-5p GPRC5A 0.854326758727003 5.04256669663285e-07 -1.98790398617405 1.71576224263651e-08 mirMAP -0.635015167621578 1.88323700836398e-10 NA NA NA hsa-miR-15a-5p GPRIN2 0.349521211668244 0.000770735998804736 -3.25654701349871 4.8807952090335e-15 mirMAP -0.746775896174857 0.000220979215787007 NA NA NA hsa-miR-19b-3p GPRIN2 0.601279551368824 0.00016685097085251 -3.25654701349871 4.8807952090335e-15 mirMAP -0.308539945346774 0.0185046536517726 NA NA NA hsa-miR-20a-5p GPRIN2 0.854326758727003 5.04256669663285e-07 -3.25654701349871 4.8807952090335e-15 mirMAP -0.434581475120863 0.00035356600732262 NA NA NA hsa-miR-455-5p GPRIN3 -0.270546034117157 0.0581320703577731 -0.836149193915687 0.000666854724822906 miRanda -0.622538112348863 3.43039974843834e-14 NA NA NA hsa-miR-192-5p GPSM2 -0.50188499512787 0.00344713341196035 1.45389191030237 4.5650425831655e-20 miRNAWalker2_validate -0.118432887357732 0.0119720676753909 NA NA NA hsa-miR-29c-3p GPX7 -1.4367517608807 1.61767774905781e-21 0.242748278541907 0.324017600889457 MirTarget;miRNATAP -0.362312577479615 1.34431746414644e-06 NA NA NA hsa-miR-146b-5p GRAMD1C 0.419719546795449 0.0457375823220155 -2.19730873706031 5.18505665584764e-22 miRanda -0.217074552632064 8.98344703106341e-05 NA NA NA hsa-miR-15a-5p GRAMD3 0.349521211668244 0.000770735998804736 -0.644653008314935 1.85257840666131e-12 MirTarget -0.140172986128134 0.00147753398372845 NA NA NA hsa-miR-21-5p GRAMD3 1.51084295924322 1.54551622173259e-34 -0.644653008314935 1.85257840666131e-12 MirTarget -0.269437888121112 3.43421721008377e-16 NA NA NA hsa-miR-455-3p GRAMD4 -1.3998033821095 5.72010709806871e-17 -0.393383820086743 0.0274859476862088 mirMAP -0.13331270416747 0.00782338879503323 NA NA NA hsa-miR-192-3p GRAP2 -0.6401165114007 0.000266272092403814 -0.313062061097117 0.227975848060346 MirTarget -0.295021594068143 3.48775957209015e-05 NA NA NA hsa-miR-19b-3p GRB10 0.601279551368824 0.00016685097085251 0.112334132178844 0.195686300080521 MirTarget -0.110420379408936 2.29504598581617e-05 NA NA NA hsa-miR-132-3p GREB1L 0.323796239695997 0.00272093067935091 0.518948993790798 0.0519108460329265 mirMAP -0.296033437806027 0.0146408698793541 NA NA NA hsa-miR-432-5p GREB1L -0.536178819038888 0.0748623258271085 0.518948993790798 0.0519108460329265 mirMAP -0.195822870800689 5.30659973819591e-06 NA NA NA hsa-miR-20a-5p GREM2 0.854326758727003 5.04256669663285e-07 -3.6542600937751 6.32290251963313e-12 mirMAP -0.474006133075032 0.00216553404000178 NA NA NA hsa-miR-503-5p GREM2 0.191949282338049 0.268420664548092 -3.6542600937751 6.32290251963313e-12 MirTarget -0.397986164527978 0.00972612789207246 NA NA NA hsa-miR-194-5p GRHL2 -0.292530160992458 0.0996141384876663 -3.71068446276051 1.97450241761239e-19 MirTarget;miRNATAP -0.438465370441165 0.000203239990224058 NA NA NA hsa-miR-20a-5p GRHL2 0.854326758727003 5.04256669663285e-07 -3.71068446276051 1.97450241761239e-19 miRNATAP -0.355380620365655 0.00360998252234944 NA NA NA hsa-miR-455-5p GRIA3 -0.270546034117157 0.0581320703577731 -2.25423263802013 1.18116781195467e-06 miRanda -0.424144969626875 0.00841903110184044 NA NA NA hsa-miR-146b-5p GRID1 0.419719546795449 0.0457375823220155 -0.061688542489256 0.885190528904441 PITA;miRanda;miRNATAP -0.277579076800782 0.00500776611044498 NA NA NA hsa-miR-27b-3p GRIN2D -0.823491817819754 9.20935302746823e-14 0.461684207778553 0.0401010164532733 miRNATAP -0.33255755619224 0.000586170418079747 NA NA NA hsa-miR-27b-3p GRK6 -0.823491817819754 9.20935302746823e-14 0.817674461563003 2.00625242116401e-19 MirTarget -0.171015198355863 2.4581985012161e-05 NA NA NA hsa-miR-29c-3p GRPEL2 -1.4367517608807 1.61767774905781e-21 0.65712951992937 1.31065567027786e-19 MirTarget -0.144873430856584 2.10534865155316e-10 NA NA NA hsa-miR-17-3p GRPR 0.410352776142368 0.00422200500748636 1.95894036197224 5.47026887537096e-07 miRNAWalker2_validate -0.786919738285158 2.9238960970136e-09 NA NA NA hsa-miR-15a-5p GRSF1 0.349521211668244 0.000770735998804736 -0.308770733373591 7.74543997813125e-06 mirMAP -0.186146368603861 6.88263219157898e-09 NA NA NA hsa-miR-19b-3p GRSF1 0.601279551368824 0.00016685097085251 -0.308770733373591 7.74543997813125e-06 MirTarget;miRNATAP -0.128850354253162 4.39258889566508e-10 NA NA NA hsa-miR-20a-5p GRSF1 0.854326758727003 5.04256669663285e-07 -0.308770733373591 7.74543997813125e-06 mirMAP -0.128451784311699 2.19549621556709e-11 NA NA NA hsa-miR-192-5p GSG2 -0.50188499512787 0.00344713341196035 2.50195748255043 2.70800537781259e-29 miRNAWalker2_validate -0.184595965944579 0.00650239577922525 NA NA NA hsa-miR-215-5p GSG2 -0.981544773246509 3.14452272477156e-05 2.50195748255043 2.70800537781259e-29 miRNAWalker2_validate -0.158124386006813 0.00122596831519111 NA NA NA hsa-miR-29c-3p GSTA4 -1.4367517608807 1.61767774905781e-21 0.792058037824552 6.38993516865996e-06 miRNATAP -0.196030531782807 0.000312087773895848 NA NA NA hsa-miR-15a-5p GSTCD 0.349521211668244 0.000770735998804736 0.314842908752809 0.00832404082779223 MirTarget -0.161131458718078 0.00415646415791735 NA NA NA hsa-miR-181a-5p GSTM2 0.250113435902954 0.0551933249319293 -1.68995962552465 6.56591679423331e-05 miRNAWalker2_validate -0.466279839091734 0.00359291430553736 NA NA NA hsa-miR-20a-5p GSTM3 0.854326758727003 5.04256669663285e-07 -0.312654249223946 0.273178695247407 mirMAP -0.309976845647473 0.000116105830842585 NA NA NA hsa-miR-455-5p GSTM3 -0.270546034117157 0.0581320703577731 -0.312654249223946 0.273178695247407 miRanda -0.196111401572928 0.0450148382335348 NA NA NA hsa-miR-19b-3p GTF2A1 0.601279551368824 0.00016685097085251 -0.686715241762695 0.00535884343767192 MirTarget;miRNATAP -0.192992409352529 0.0102589203184562 NA NA NA hsa-miR-21-5p GTF2A1 1.51084295924322 1.54551622173259e-34 -0.686715241762695 0.00535884343767192 miRNAWalker2_validate -0.432330601899388 1.32918511417795e-06 NA NA NA hsa-miR-30b-5p GTF2A1 -0.54056186708617 2.44688760798341e-05 -0.686715241762695 0.00535884343767192 mirMAP -0.305148233318218 0.00111166089466654 NA NA NA hsa-miR-99a-5p GTF2H2C -1.51481656384839 3.93230057259529e-14 0.749668785905835 8.49952527849053e-11 miRNAWalker2_validate -0.197082045440538 3.31872487531846e-13 NA NA NA hsa-miR-21-5p GTF2I 1.51084295924322 1.54551622173259e-34 -0.00748089243032002 0.968048343679462 miRNAWalker2_validate -0.228506436155094 0.000758135102357862 NA NA NA hsa-miR-146b-5p GTF2IRD2 0.419719546795449 0.0457375823220155 -0.265716477037074 0.0155099439762369 miRanda -0.13701439121917 4.80424486767986e-08 NA NA NA hsa-miR-146b-5p GTF2IRD2B 0.419719546795449 0.0457375823220155 -0.31868533854201 0.0160580009271973 miRanda -0.146016837296395 1.57817578853439e-06 NA NA NA hsa-miR-181a-5p GTPBP10 0.250113435902954 0.0551933249319293 -0.208858907279597 0.0121408412268073 mirMAP -0.181814934523779 3.04090560961174e-09 NA NA NA hsa-miR-181b-5p GTPBP10 0.488256489401108 0.00105321129419701 -0.208858907279597 0.0121408412268073 mirMAP -0.180967956266462 8.44032610646524e-12 NA NA NA hsa-miR-29c-3p GTPBP2 -1.4367517608807 1.61767774905781e-21 0.912600696484504 3.85659059390209e-18 miRNATAP -0.260055382801175 1.42305793269233e-15 NA NA NA hsa-miR-221-3p GUCY1A2 1.12244756358612 3.48370308238012e-13 0.0715677649443884 0.676881020366457 MirTarget -0.213204118706513 4.72670178076662e-05 NA NA NA hsa-miR-222-3p GUCY1A2 1.08574156066353 1.76407192348131e-11 0.0715677649443884 0.676881020366457 MirTarget -0.165369816417951 0.00104694682953543 NA NA NA hsa-miR-455-5p GUCY1B3 -0.270546034117157 0.0581320703577731 -0.627980755144916 0.000348078195483559 miRanda -0.308223978099136 2.50626134094444e-07 NA NA NA hsa-miR-192-5p GULP1 -0.50188499512787 0.00344713341196035 -0.40117278239696 0.328073008560451 miRNAWalker2_validate -0.677190576744881 3.15242584216331e-09 NA NA NA hsa-miR-455-5p GULP1 -0.270546034117157 0.0581320703577731 -0.40117278239696 0.328073008560451 miRanda -0.74824499967094 6.67291872610439e-08 NA NA NA hsa-miR-21-5p GXYLT1 1.51084295924322 1.54551622173259e-34 -0.349240174864085 3.06569030604751e-05 mirMAP -0.165206324251823 4.93697672660951e-08 NA NA NA hsa-miR-30b-5p GXYLT1 -0.54056186708617 2.44688760798341e-05 -0.349240174864085 3.06569030604751e-05 mirMAP -0.113497472365148 0.000356314284769128 NA NA NA hsa-miR-29c-3p GXYLT2 -1.4367517608807 1.61767774905781e-21 0.969591025254963 0.00462307972031421 MirTarget -0.339506387037115 0.00129801710895081 NA NA NA hsa-miR-194-5p GYG1 -0.292530160992458 0.0996141384876663 0.267519295497328 0.00477675130509514 MirTarget;miRNATAP -0.252627357582332 8.8317875625486e-25 NA NA NA hsa-miR-455-5p GYG1 -0.270546034117157 0.0581320703577731 0.267519295497328 0.00477675130509514 miRanda -0.145401960226954 6.3257218352591e-06 NA NA NA hsa-miR-27b-3p H2AFZ -0.823491817819754 9.20935302746823e-14 1.04060285300063 3.49847347703049e-19 miRNATAP -0.286705963252837 2.7410475707931e-08 NA NA NA hsa-miR-146a-5p H6PD -0.742958238440575 0.000765983177482633 -0.159284401461308 0.269264574065681 mirMAP -0.166565680849468 9.34231822544699e-08 NA NA NA hsa-miR-19b-3p HABP4 0.601279551368824 0.00016685097085251 0.383004886749933 0.0065168011083657 miRNAWalker2_validate -0.136736380686185 0.00138600595343432 NA NA NA hsa-miR-132-3p HAO1 0.323796239695997 0.00272093067935091 -2.20356042459299 6.06345075640698e-11 miRNATAP -1.12776811727105 1.2290552292999e-13 NA NA NA hsa-miR-122-3p HAPLN1 -1.75369011054591 1.52070648599898e-11 1.33038232891219 0.000123661512782167 MirTarget -0.266568910327166 2.66478985562167e-05 NA NA NA hsa-miR-27b-3p HAPLN1 -0.823491817819754 9.20935302746823e-14 1.33038232891219 0.000123661512782167 MirTarget;miRNATAP -0.681140839314463 5.0234333428161e-06 NA NA NA hsa-miR-127-3p HAPLN4 -1.0751374948053 2.19322892330221e-05 -1.19507848656308 3.30223182887354e-05 miRanda -0.146904107287042 0.00793688159789035 NA NA NA hsa-miR-132-3p HAPLN4 0.323796239695997 0.00272093067935091 -1.19507848656308 3.30223182887354e-05 mirMAP -0.959087986265892 6.60141085393442e-14 NA NA NA hsa-miR-15a-5p HAS2 0.349521211668244 0.000770735998804736 -2.63463009380978 1.12278136651369e-12 MirTarget -0.894679023091235 4.73868052789485e-07 NA NA NA hsa-miR-20a-5p HAS2 0.854326758727003 5.04256669663285e-07 -2.63463009380978 1.12278136651369e-12 MirTarget -0.440242041373886 4.12785612456204e-05 NA NA NA hsa-miR-148a-3p HAS3 -0.748702855596996 3.93313343865641e-07 0.499425712466684 0.000692477830824529 miRNATAP -0.169268758647117 0.000440496808434031 NA NA NA hsa-miR-192-3p HAS3 -0.6401165114007 0.000266272092403814 0.499425712466684 0.000692477830824529 mirMAP -0.101694525835144 0.0128385670236967 NA NA NA hsa-miR-192-5p HAS3 -0.50188499512787 0.00344713341196035 0.499425712466684 0.000692477830824529 miRNAWalker2_validate -0.114818402057775 0.00614909396360974 NA NA NA hsa-miR-29c-3p HAS3 -1.4367517608807 1.61767774905781e-21 0.499425712466684 0.000692477830824529 miRNATAP -0.124033308048094 0.00641023037110096 NA NA NA hsa-miR-455-5p HAVCR2 -0.270546034117157 0.0581320703577731 -0.759818094632805 9.89820300005107e-05 miRanda -0.362621740835893 4.76563228984559e-08 NA NA NA hsa-miR-17-3p HBEGF 0.410352776142368 0.00422200500748636 -0.836710148093972 5.03009801941881e-09 MirTarget -0.253187109664835 2.30933960212345e-07 NA NA NA hsa-miR-192-5p HBEGF -0.50188499512787 0.00344713341196035 -0.836710148093972 5.03009801941881e-09 miRNAWalker2_validate -0.234100358517178 8.58266797561741e-09 NA NA NA hsa-miR-194-5p HBEGF -0.292530160992458 0.0996141384876663 -0.836710148093972 5.03009801941881e-09 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.258733558316366 3.93546901756595e-11 NA NA NA hsa-miR-17-3p HBP1 0.410352776142368 0.00422200500748636 -0.357103377571568 1.81649948774568e-05 miRNAWalker2_validate;MirTarget -0.169879392197215 1.2329232226853e-09 20505989 miR 17 5p promotes human breast cancer cell migration and invasion through suppression of HBP1 cell migration breast cancer hsa-miR-19b-3p HBP1 0.601279551368824 0.00016685097085251 -0.357103377571568 1.81649948774568e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.118436736586274 2.61721378382982e-06 NA NA NA hsa-miR-20a-5p HBP1 0.854326758727003 5.04256669663285e-07 -0.357103377571568 1.81649948774568e-05 MirTarget;miRNATAP -0.113858473192472 1.25060213333006e-06 NA NA NA hsa-miR-21-5p HBP1 1.51084295924322 1.54551622173259e-34 -0.357103377571568 1.81649948774568e-05 miRNATAP -0.235889270910882 1.4074266579388e-15 26282675 MicroRNA 21 is a potential link between non alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1 p53 Srebp1c pathway; Further studies revealed that Hbp1 was a novel target of microRNA-21 and a transcriptional activator of p53 liver cancer hsa-miR-19b-3p HCFC2 0.601279551368824 0.00016685097085251 -0.267608506836593 0.00645363991292462 MirTarget -0.100336594771027 0.000748855294412809 NA NA NA hsa-miR-455-3p HCK -1.3998033821095 5.72010709806871e-17 -1.11641024244849 3.53677860354143e-09 miRNATAP -0.186187882265679 0.000553953639085291 NA NA NA hsa-miR-192-5p HCN4 -0.50188499512787 0.00344713341196035 -0.156605172711939 0.62901535993883 miRNAWalker2_validate -0.750320170158889 2.02075374764777e-17 NA NA NA hsa-miR-455-5p HCN4 -0.270546034117157 0.0581320703577731 -0.156605172711939 0.62901535993883 miRanda -0.557760661759862 3.64904681969317e-07 NA NA NA hsa-miR-192-3p HDAC4 -0.6401165114007 0.000266272092403814 1.00691818288109 6.96034330486747e-18 mirMAP -0.17138330494453 2.50163363044454e-07 NA NA NA hsa-miR-29c-3p HDAC4 -1.4367517608807 1.61767774905781e-21 1.00691818288109 6.96034330486747e-18 MirTarget;miRNATAP -0.22578693154779 8.29620742867992e-10 NA NA NA hsa-miR-181a-5p HDAC6 0.250113435902954 0.0551933249319293 -0.857516037204713 1.5281084242686e-12 miRNAWalker2_validate -0.365957379640252 5.13058368775291e-16 NA NA NA hsa-miR-455-5p HDAC9 -0.270546034117157 0.0581320703577731 -1.15719039438144 2.74522046804511e-08 miRanda -0.416152366236071 5.47966947735502e-09 NA NA NA hsa-miR-146b-5p HDX 0.419719546795449 0.0457375823220155 -0.727107457485361 0.00193923996731702 miRanda -0.213471617760629 8.57502805563573e-05 NA NA NA hsa-miR-20a-5p HECA 0.854326758727003 5.04256669663285e-07 -0.704842603143831 7.46272240332447e-12 miRNATAP -0.137811858167133 3.22184135934466e-06 NA NA NA hsa-miR-15a-5p HECTD1 0.349521211668244 0.000770735998804736 -0.512253958763233 2.26630270647066e-07 miRNATAP -0.144914612790967 0.00209041361764633 NA NA NA hsa-miR-21-5p HECTD1 1.51084295924322 1.54551622173259e-34 -0.512253958763233 2.26630270647066e-07 miRNAWalker2_validate -0.378550769030999 1.41086458902319e-28 NA NA NA hsa-miR-221-3p HECTD1 1.12244756358612 3.48370308238012e-13 -0.512253958763233 2.26630270647066e-07 miRNAWalker2_validate -0.122744599499136 6.07660978879542e-05 NA NA NA hsa-miR-19b-3p HECW2 0.601279551368824 0.00016685097085251 -0.453603053800375 0.00649211297206005 MirTarget -0.170955023353926 0.000731062681325776 NA NA NA hsa-miR-19b-3p HEG1 0.601279551368824 0.00016685097085251 0.175697577625922 0.209861547402414 miRNAWalker2_validate;mirMAP;miRNATAP -0.11980178304769 0.00478903295139033 NA NA NA hsa-miR-20a-5p HEG1 0.854326758727003 5.04256669663285e-07 0.175697577625922 0.209861547402414 miRNATAP -0.132679807492237 0.000789733039034406 NA NA NA hsa-miR-181a-5p HEMK1 0.250113435902954 0.0551933249319293 0.0638411526846525 0.448919076689463 mirMAP -0.12814111859113 4.19547891815035e-05 NA NA NA hsa-miR-181b-5p HEMK1 0.488256489401108 0.00105321129419701 0.0638411526846525 0.448919076689463 mirMAP -0.15943267250684 3.1555471532804e-09 NA NA NA hsa-miR-146b-5p HEPH 0.419719546795449 0.0457375823220155 -0.649904790726787 0.00203115358590629 miRanda -0.100104953149982 0.0415327487695047 NA NA NA hsa-miR-30b-5p HERC2 -0.54056186708617 2.44688760798341e-05 0.169506644964027 0.0521769816110822 MirTarget -0.137302347757172 2.79579445805021e-05 NA NA NA hsa-miR-181a-5p HERC3 0.250113435902954 0.0551933249319293 -1.05715572381348 2.92415816206899e-12 miRNAWalker2_validate -0.270623815195438 2.89282875215874e-06 NA NA NA hsa-miR-15a-5p HERC6 0.349521211668244 0.000770735998804736 -0.870566486509483 1.37012981254318e-05 miRNAWalker2_validate -0.371524982291968 8.82140914487057e-05 NA NA NA hsa-miR-20a-5p HES2 0.854326758727003 5.04256669663285e-07 1.80546502926672 2.25475279863592e-08 mirMAP -0.210635214254067 0.0238328380967858 NA NA NA hsa-miR-455-3p HES2 -1.3998033821095 5.72010709806871e-17 1.80546502926672 2.25475279863592e-08 mirMAP -0.401059675959291 1.18231358313712e-05 NA NA NA hsa-miR-455-3p HEY1 -1.3998033821095 5.72010709806871e-17 1.22795353714095 5.29983431753324e-16 PITA -0.134384466689679 0.00227722235657107 NA NA NA hsa-miR-181a-5p HEY2 0.250113435902954 0.0551933249319293 -1.34767831175623 1.66295690242859e-12 miRNAWalker2_validate;miRNATAP -0.315006445122757 1.66228537378966e-05 NA NA NA hsa-miR-181b-5p HEY2 0.488256489401108 0.00105321129419701 -1.34767831175623 1.66295690242859e-12 miRNATAP -0.325246834178081 2.82240288650486e-07 NA NA NA hsa-miR-146b-5p HEYL 0.419719546795449 0.0457375823220155 0.295845702141142 0.19216669936656 miRanda -0.106944628073281 0.0422619845877705 NA NA NA hsa-miR-20a-5p HFE 0.854326758727003 5.04256669663285e-07 -0.15872348517792 0.35310321637109 mirMAP -0.133374430060925 0.00579588610970805 NA NA NA hsa-miR-30b-5p HFE -0.54056186708617 2.44688760798341e-05 -0.15872348517792 0.35310321637109 mirMAP -0.312433930179638 1.07284615603083e-06 NA NA NA hsa-miR-224-3p HGF 1.40770116795301 1.31426607144612e-08 -3.45738625921135 1.44942707549128e-24 mirMAP -0.24700467708681 0.000422016473692453 NA NA NA hsa-miR-21-5p HHIP 1.51084295924322 1.54551622173259e-34 -5.86031709546153 8.91627452602351e-41 mirMAP -1.12169197316927 1.01232747513074e-10 NA NA NA hsa-miR-224-3p HHIP 1.40770116795301 1.31426607144612e-08 -5.86031709546153 8.91627452602351e-41 mirMAP -0.429279007664964 5.27129702360086e-06 NA NA NA hsa-miR-15a-5p HHIPL1 0.349521211668244 0.000770735998804736 -0.6627728247093 0.000915935659771985 mirMAP -0.33857427784257 0.000331183462402427 NA NA NA hsa-miR-194-5p HHLA2 -0.292530160992458 0.0996141384876663 -0.476210640721523 0.162062341199659 MirTarget -0.190213936898349 0.0424553104714464 NA NA NA hsa-miR-19b-3p HIC1 0.601279551368824 0.00016685097085251 -0.724123888659103 3.45513048538055e-06 MirTarget -0.179819566681726 0.000162878720413131 NA NA NA hsa-miR-34a-5p HIC2 1.03694231790865 5.74864019540594e-14 0.940776893137958 6.46839631810595e-09 mirMAP -0.165026721217665 0.0035679991236519 NA NA NA hsa-miR-20a-5p HIF1A 0.854326758727003 5.04256669663285e-07 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate;miRTarBase;MirTarget -0.245558453559623 9.83134714947215e-10 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-182-5p HIF3A 1.96601340710222 4.39326175603633e-09 -0.432790060092153 0.111359222900488 mirMAP -0.189338473805484 7.96453006330465e-07 NA NA NA hsa-miR-224-3p HIF3A 1.40770116795301 1.31426607144612e-08 -0.432790060092153 0.111359222900488 mirMAP -0.105857858236705 0.047201602314933 NA NA NA hsa-miR-127-3p HINT2 -1.0751374948053 2.19322892330221e-05 -0.694174247776646 9.49481656675262e-07 miRanda -0.106300448698885 9.08639289524197e-05 NA NA NA hsa-miR-146a-5p HIP1 -0.742958238440575 0.000765983177482633 -0.0194429374173284 0.918692239168554 mirMAP -0.149936559323519 0.000312740718069921 NA NA NA hsa-miR-146b-5p HIP1 0.419719546795449 0.0457375823220155 -0.0194429374173284 0.918692239168554 mirMAP -0.122897216945886 0.00528100064079103 NA NA NA hsa-miR-19b-3p HIP1 0.601279551368824 0.00016685097085251 -0.0194429374173284 0.918692239168554 MirTarget -0.14220373721341 0.0138717718278603 NA NA NA hsa-miR-20a-5p HIP1 0.854326758727003 5.04256669663285e-07 -0.0194429374173284 0.918692239168554 MirTarget -0.189500746866077 0.000416765539407245 NA NA NA hsa-miR-409-3p HIP1 -0.499649792570937 0.0526751181520117 -0.0194429374173284 0.918692239168554 mirMAP -0.102386445550898 0.00429534335528216 NA NA NA hsa-miR-455-5p HIP1 -0.270546034117157 0.0581320703577731 -0.0194429374173284 0.918692239168554 mirMAP -0.170554655334042 0.00880939406960925 NA NA NA hsa-miR-181a-5p HIPK1 0.250113435902954 0.0551933249319293 -0.16031440103832 0.127196102040304 mirMAP -0.128020646607132 0.00110953466530975 NA NA NA hsa-miR-21-5p HIPK1 1.51084295924322 1.54551622173259e-34 -0.16031440103832 0.127196102040304 mirMAP -0.108627540305843 0.00448750637888426 NA NA NA hsa-miR-221-3p HIPK1 1.12244756358612 3.48370308238012e-13 -0.16031440103832 0.127196102040304 MirTarget;miRNATAP -0.114800628703969 0.000350703360286203 NA NA NA hsa-miR-17-3p HIPK2 0.410352776142368 0.00422200500748636 -0.239689841914744 0.0838927941290475 mirMAP -0.138945105650751 0.00314606029936834 NA NA NA hsa-miR-181a-5p HIPK2 0.250113435902954 0.0551933249319293 -0.239689841914744 0.0838927941290475 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.318847288494212 4.1073988855542e-10 NA NA NA hsa-miR-181b-5p HIPK2 0.488256489401108 0.00105321129419701 -0.239689841914744 0.0838927941290475 mirMAP;miRNATAP -0.297128209508301 1.8229823488911e-11 NA NA NA hsa-miR-19b-3p HIPK2 0.601279551368824 0.00016685097085251 -0.239689841914744 0.0838927941290475 mirMAP -0.119877470542306 0.00436984217249601 NA NA NA hsa-miR-20a-5p HIPK2 0.854326758727003 5.04256669663285e-07 -0.239689841914744 0.0838927941290475 mirMAP -0.147341560656338 0.000163378093557306 NA NA NA hsa-miR-221-3p HIPK2 1.12244756358612 3.48370308238012e-13 -0.239689841914744 0.0838927941290475 miRNATAP -0.20708116108492 9.03305228275801e-07 NA NA NA hsa-miR-222-3p HIPK2 1.08574156066353 1.76407192348131e-11 -0.239689841914744 0.0838927941290475 miRNAWalker2_validate;miRNATAP -0.208284105869186 2.5222728961609e-07 NA NA NA hsa-miR-30b-5p HIPK2 -0.54056186708617 2.44688760798341e-05 -0.239689841914744 0.0838927941290475 miRNATAP -0.248692973844395 1.74905394060525e-06 NA NA NA hsa-miR-146b-5p HIPK3 0.419719546795449 0.0457375823220155 -1.50429429958896 1.36124385011385e-07 MirTarget -0.166910586228675 0.0130359893265189 NA NA NA hsa-miR-17-3p HIPK3 0.410352776142368 0.00422200500748636 -1.50429429958896 1.36124385011385e-07 MirTarget;miRNATAP -0.374879129334736 0.000132350754065365 NA NA NA hsa-miR-19b-3p HIPK3 0.601279551368824 0.00016685097085251 -1.50429429958896 1.36124385011385e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.256170781256075 0.00359094545925197 NA NA NA hsa-miR-21-5p HIPK3 1.51084295924322 1.54551622173259e-34 -1.50429429958896 1.36124385011385e-07 MirTarget -0.578663959515645 2.86739236558473e-08 NA NA NA hsa-miR-221-3p HIPK3 1.12244756358612 3.48370308238012e-13 -1.50429429958896 1.36124385011385e-07 MirTarget -0.301787858496408 0.000683773574086624 NA NA NA hsa-miR-222-3p HIPK3 1.08574156066353 1.76407192348131e-11 -1.50429429958896 1.36124385011385e-07 MirTarget -0.229263190907443 0.00732430676554254 NA NA NA hsa-miR-455-5p HIPK3 -0.270546034117157 0.0581320703577731 -1.50429429958896 1.36124385011385e-07 miRanda -0.282614423914441 0.00437918640569569 NA NA NA hsa-miR-27b-3p HIST1H1C -0.823491817819754 9.20935302746823e-14 0.809397548723961 0.000555269225773258 miRNAWalker2_validate -0.216663820228268 0.0332027419682172 NA NA NA hsa-miR-652-3p HIST1H1C 0.135945800164278 0.391695970197646 0.809397548723961 0.000555269225773258 miRNAWalker2_validate -0.191519158059256 0.00840190422719316 NA NA NA hsa-miR-99b-5p HIST1H1C -0.204769880349524 0.240836989110525 0.809397548723961 0.000555269225773258 miRNAWalker2_validate -0.265113512330983 5.32276460643545e-05 NA NA NA hsa-miR-652-3p HIST1H2BD 0.135945800164278 0.391695970197646 0.0575848369914294 0.768877155051809 miRNAWalker2_validate -0.237682840247663 7.42574774645682e-05 NA NA NA hsa-miR-221-3p HIVEP1 1.12244756358612 3.48370308238012e-13 -1.10787940806176 3.2752718772151e-16 miRNAWalker2_validate -0.20729234794859 1.32454788862852e-06 NA NA NA hsa-miR-455-5p HIVEP1 -0.270546034117157 0.0581320703577731 -1.10787940806176 3.2752718772151e-16 miRanda -0.103455556976981 0.0321310547907678 NA NA NA hsa-miR-215-5p HJURP -0.981544773246509 3.14452272477156e-05 3.99476358855405 1.38406738400505e-49 miRNAWalker2_validate -0.175757366021045 0.00494275042607333 NA NA NA hsa-miR-34a-5p HK1 1.03694231790865 5.74864019540594e-14 -0.0669879348030658 0.685045468712279 MirTarget;miRNATAP -0.214248925224056 0.000144233794060016 NA NA NA hsa-miR-455-5p HLA-DMB -0.270546034117157 0.0581320703577731 -0.2685157047933 0.172461505512085 miRanda -0.404089527364493 1.00535269217459e-09 NA NA NA hsa-miR-192-3p HLA-DOA -0.6401165114007 0.000266272092403814 -1.05538220409473 1.86886688832567e-06 mirMAP -0.329014569880305 7.23997551941172e-08 NA NA NA hsa-miR-455-5p HLA-DOA -0.270546034117157 0.0581320703577731 -1.05538220409473 1.86886688832567e-06 miRanda -0.371152076270561 1.02838635211004e-06 NA NA NA hsa-miR-455-5p HLA-DQA1 -0.270546034117157 0.0581320703577731 -0.691198730104436 0.00457115775466812 miRanda -0.365850244633145 1.07961320976605e-05 NA NA NA hsa-miR-181a-5p HLF 0.250113435902954 0.0551933249319293 -1.56359740264692 3.39928227602253e-08 MirTarget;miRNATAP -0.831627203116347 1.85388323838238e-15 NA NA NA hsa-miR-181b-5p HLF 0.488256489401108 0.00105321129419701 -1.56359740264692 3.39928227602253e-08 MirTarget;miRNATAP -0.906166223170333 2.02680662950786e-24 NA NA NA hsa-miR-19b-3p HLF 0.601279551368824 0.00016685097085251 -1.56359740264692 3.39928227602253e-08 miRNATAP -0.266959682023246 0.00225594094143058 NA NA NA hsa-miR-20a-5p HLF 0.854326758727003 5.04256669663285e-07 -1.56359740264692 3.39928227602253e-08 MirTarget;miRNATAP -0.227940593135166 0.00521161423637292 NA NA NA hsa-miR-20b-5p HLF 0.457668023910379 0.0285865211936156 -1.56359740264692 3.39928227602253e-08 MirTarget;miRNATAP -0.251744999467679 0.000164358461397303 NA NA NA hsa-miR-127-3p HLX -1.0751374948053 2.19322892330221e-05 -0.471491535693022 0.000986831563108467 miRanda -0.107693687176092 7.66210332521823e-05 NA NA NA hsa-miR-455-3p HM13 -1.3998033821095 5.72010709806871e-17 0.613339424464198 7.99869970795878e-11 MirTarget;PITA;miRNATAP -0.104536285004629 0.00010124831111284 NA NA NA hsa-miR-15a-5p HMBOX1 0.349521211668244 0.000770735998804736 -0.648299686508313 1.92402108459881e-07 MirTarget -0.170662855094798 0.00405771713627738 NA NA NA hsa-miR-20a-5p HMBOX1 0.854326758727003 5.04256669663285e-07 -0.648299686508313 1.92402108459881e-07 MirTarget;miRNATAP -0.166694525166171 2.52385249865366e-06 NA NA NA hsa-miR-221-3p HMBOX1 1.12244756358612 3.48370308238012e-13 -0.648299686508313 1.92402108459881e-07 MirTarget;miRNATAP -0.141745318893312 0.000243612435054518 NA NA NA hsa-miR-181a-5p HMBS 0.250113435902954 0.0551933249319293 0.408525618362018 9.51669585366333e-06 MirTarget -0.108584937974602 0.00180756143547574 NA NA NA hsa-miR-181b-5p HMBS 0.488256489401108 0.00105321129419701 0.408525618362018 9.51669585366333e-06 MirTarget -0.102339523846352 0.000714179744096593 NA NA NA hsa-miR-30c-5p HMGA1 -0.432111642767632 0.000159764714931007 1.52957485940098 1.79164981120061e-17 miRNAWalker2_validate -0.364863586420043 4.00700270230295e-06 NA NA NA hsa-miR-30e-5p HMGA2 -0.627815042856657 3.02205690184908e-10 1.11519648679255 0.015940340984894 mirMAP -0.798500838474147 0.000352279983828195 NA NA NA hsa-miR-34a-5p HMGA2 1.03694231790865 5.74864019540594e-14 1.11519648679255 0.015940340984894 miRNAWalker2_validate -0.544514172218724 0.000610403792176777 18803879 miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making poor survival;differentiation gastric cancer hsa-miR-181a-5p HMGB3 0.250113435902954 0.0551933249319293 0.214686464665506 0.255755943147257 mirMAP -0.193442993515394 0.00629756900038389 NA NA NA hsa-miR-29c-3p HMGCR -1.4367517608807 1.61767774905781e-21 -0.0255381303027127 0.860855033325736 miRNAWalker2_validate;miRNATAP -0.19468046465415 1.16519970420017e-05 NA NA NA hsa-miR-127-3p HMGN5 -1.0751374948053 2.19322892330221e-05 -1.78827193988144 6.06264629010839e-11 miRanda -0.168804404980408 0.00152315080133489 NA NA NA hsa-miR-455-3p HN1 -1.3998033821095 5.72010709806871e-17 1.07503304566676 4.2045253941593e-14 MirTarget;PITA;miRNATAP -0.222874353175391 4.15440709682617e-08 NA NA NA hsa-miR-29c-3p HNRNPUL1 -1.4367517608807 1.61767774905781e-21 0.351799893656354 1.65531888060193e-08 miRNATAP -0.140952968494119 6.42361209482956e-14 NA NA NA hsa-miR-148a-3p HOMER1 -0.748702855596996 3.93313343865641e-07 -0.0763641412081514 0.796151529043688 MirTarget -0.666575262467855 1.35873064627191e-12 NA NA NA hsa-miR-221-3p HOOK1 1.12244756358612 3.48370308238012e-13 -1.00940473494578 9.98206390806586e-11 MirTarget -0.208587200086646 1.88071993726591e-05 NA NA NA hsa-miR-222-3p HOOK1 1.08574156066353 1.76407192348131e-11 -1.00940473494578 9.98206390806586e-11 MirTarget -0.150309549395771 0.00138494249468454 NA NA NA hsa-miR-215-5p HOXA10 -0.981544773246509 3.14452272477156e-05 3.42398413145372 4.35734270924277e-13 miRNAWalker2_validate -0.204273597135269 0.0409446675273897 NA NA NA hsa-miR-17-3p HOXB2 0.410352776142368 0.00422200500748636 -0.163601232374304 0.248979207558921 miRNAWalker2_validate -0.11817094781201 0.0141918832058006 NA NA NA hsa-miR-146b-5p HOXB3 0.419719546795449 0.0457375823220155 0.00641821806054166 0.972231261941102 miRanda -0.122413077352389 0.00409024244040037 NA NA NA hsa-miR-455-3p HOXB5 -1.3998033821095 5.72010709806871e-17 -0.0885605067710944 0.618412773780255 PITA;miRNATAP -0.15913632186434 0.00136850135618191 NA NA NA hsa-miR-505-5p HOXB5 -0.768282569967001 1.14662846595407e-05 -0.0885605067710944 0.618412773780255 miRNATAP -0.117380942238825 0.0166521376357977 NA NA NA hsa-miR-455-5p HOXB6 -0.270546034117157 0.0581320703577731 -0.317836639417789 0.123588664566557 miRNATAP -0.228211014921726 0.00121156684643378 NA NA NA hsa-miR-455-3p HOXB7 -1.3998033821095 5.72010709806871e-17 0.803065713838819 0.000994365965542123 PITA -0.292443459525665 1.87766351976053e-05 NA NA NA hsa-miR-192-5p HOXB9 -0.50188499512787 0.00344713341196035 1.2945297060988 0.000123494835110063 miRNAWalker2_validate -0.817193266733572 9.01824638916809e-19 NA NA NA hsa-miR-215-5p HOXB9 -0.981544773246509 3.14452272477156e-05 1.2945297060988 0.000123494835110063 miRNAWalker2_validate -0.23784069806557 0.000609854860243427 NA NA NA hsa-miR-455-3p HOXC4 -1.3998033821095 5.72010709806871e-17 0.739698969245912 0.00639112605290768 PITA;miRNATAP -0.392669420851923 1.95194868518499e-07 NA NA NA hsa-miR-27b-3p HOXC6 -0.823491817819754 9.20935302746823e-14 1.6690034552265 1.06491141525181e-05 miRNATAP -0.598372323813569 0.000273458840499387 NA NA NA hsa-miR-148a-3p HOXC8 -0.748702855596996 3.93313343865641e-07 0.89168315412305 0.00741079667695049 miRNAWalker2_validate;miRNATAP -0.316760862079704 0.00368044169533115 NA NA NA hsa-miR-34a-5p HPRT1 1.03694231790865 5.74864019540594e-14 -0.318757051108572 0.00859144089987 miRNAWalker2_validate -0.129862477609094 0.00181391562106412 NA NA NA hsa-miR-20a-5p HPS5 0.854326758727003 5.04256669663285e-07 -1.54497064795797 1.96024564670947e-23 MirTarget -0.225036935244128 9.70098718500335e-07 NA NA NA hsa-miR-21-5p HPS5 1.51084295924322 1.54551622173259e-34 -1.54497064795797 1.96024564670947e-23 miRNAWalker2_validate -0.358324432918708 1.04352822729288e-09 NA NA NA hsa-miR-20a-5p HPSE 0.854326758727003 5.04256669663285e-07 -0.783944920967642 0.00198576706692966 mirMAP -0.164041864971541 0.0231280062388655 NA NA NA hsa-miR-34a-5p HPSE 1.03694231790865 5.74864019540594e-14 -0.783944920967642 0.00198576706692966 MirTarget -0.378243639055491 1.32783019255212e-05 NA NA NA hsa-miR-192-5p HRH1 -0.50188499512787 0.00344713341196035 0.340287230286828 0.0286188640920779 miRNAWalker2_validate -0.435253617003633 1.04272436194531e-25 NA NA NA hsa-miR-455-5p HRH1 -0.270546034117157 0.0581320703577731 0.340287230286828 0.0286188640920779 miRanda -0.384785853261599 1.06369647681834e-13 NA NA NA hsa-miR-146a-5p HS1BP3 -0.742958238440575 0.000765983177482633 0.385835796852614 0.00011202800525771 mirMAP -0.119669338882502 3.6166265378808e-08 NA NA NA hsa-miR-181a-5p HS2ST1 0.250113435902954 0.0551933249319293 -0.0411259109875024 0.604534462880814 mirMAP -0.111070767734925 0.000165058460794654 NA NA NA hsa-miR-30b-5p HS2ST1 -0.54056186708617 2.44688760798341e-05 -0.0411259109875024 0.604534462880814 mirMAP -0.102712383628093 0.000572012390668904 NA NA NA hsa-miR-20a-5p HS3ST1 0.854326758727003 5.04256669663285e-07 -0.516344907139293 0.0110139272698008 mirMAP -0.304719335203403 8.69461800851766e-08 NA NA NA hsa-miR-194-5p HS3ST2 -0.292530160992458 0.0996141384876663 0.521548702604161 0.0315606193984684 MirTarget;miRNATAP -0.266341158560432 6.00921433591594e-05 NA NA NA hsa-miR-455-5p HS3ST2 -0.270546034117157 0.0581320703577731 0.521548702604161 0.0315606193984684 miRanda;miRNATAP -0.409099349671547 6.69367852865942e-07 NA NA NA hsa-miR-21-5p HS3ST3B1 1.51084295924322 1.54551622173259e-34 -2.60592423161066 9.57213132909845e-18 miRNAWalker2_validate -0.976241117224746 1.34764029616548e-18 NA NA NA hsa-miR-146b-5p HS6ST2 0.419719546795449 0.0457375823220155 -0.0158151904707768 0.972541683951241 miRanda -0.221499059252064 0.0377171786058445 NA NA NA hsa-miR-21-5p HSD17B4 1.51084295924322 1.54551622173259e-34 -0.640677186239444 9.56450055730174e-06 MirTarget -0.49064613873703 3.4002637267839e-22 NA NA NA hsa-miR-27b-3p HSDL1 -0.823491817819754 9.20935302746823e-14 0.624658214600752 9.62712068001496e-10 miRNATAP -0.282093395819959 1.31895711711252e-10 NA NA NA hsa-miR-30c-5p HSP90AA1 -0.432111642767632 0.000159764714931007 0.358140551368157 9.85322237128818e-05 miRNAWalker2_validate -0.202157986427488 1.9883621574863e-07 NA NA NA hsa-miR-30e-5p HSP90AA1 -0.627815042856657 3.02205690184908e-10 0.358140551368157 9.85322237128818e-05 miRNAWalker2_validate -0.241505661403756 4.10597516818342e-08 NA NA NA hsa-miR-455-3p HSP90AB1 -1.3998033821095 5.72010709806871e-17 0.889713776257228 6.19114669909869e-19 miRNAWalker2_validate -0.1060610748927 0.000280397717598 NA NA NA hsa-miR-505-5p HSP90AB1 -0.768282569967001 1.14662846595407e-05 0.889713776257228 6.19114669909869e-19 MirTarget -0.175369328180102 5.66447338811247e-10 NA NA NA hsa-miR-455-5p HSPA13 -0.270546034117157 0.0581320703577731 0.0756800916042764 0.45588305259595 miRanda -0.113704452444879 0.000993631060329564 NA NA NA hsa-miR-192-5p HSPA2 -0.50188499512787 0.00344713341196035 0.245419691266019 0.113504150863356 miRNAWalker2_validate -0.206197602451252 2.16593621163362e-06 NA NA NA hsa-miR-30c-5p HSPA4 -0.432111642767632 0.000159764714931007 0.551172678948792 1.44335927853029e-10 miRNAWalker2_validate;miRTarBase -0.22717186455893 5.59650184362846e-10 NA NA NA hsa-miR-30c-5p HSPA5 -0.432111642767632 0.000159764714931007 0.430778579111895 1.35511482406206e-05 miRNATAP -0.165163244241474 9.30693186240472e-05 NA NA NA hsa-miR-192-5p HSPB7 -0.50188499512787 0.00344713341196035 -0.81967691208713 0.00575562764675916 mirMAP -0.715298487748838 1.0148758204378e-18 NA NA NA hsa-miR-192-5p HSPBAP1 -0.50188499512787 0.00344713341196035 0.430201326699575 2.59973730413392e-06 miRNAWalker2_validate -0.141327664152351 4.32027109534327e-08 NA NA NA hsa-miR-146b-5p HSPG2 0.419719546795449 0.0457375823220155 0.547232003403177 0.000340016191663061 miRanda -0.103599574434536 0.00358393060183562 NA NA NA hsa-miR-15a-5p HSPG2 0.349521211668244 0.000770735998804736 0.547232003403177 0.000340016191663061 MirTarget -0.224822189229871 0.00185482528408297 NA NA NA hsa-miR-455-3p HSPG2 -1.3998033821095 5.72010709806871e-17 0.547232003403177 0.000340016191663061 PITA;miRNATAP -0.15793624812411 0.000233890271472352 NA NA NA hsa-miR-30c-5p HSPH1 -0.432111642767632 0.000159764714931007 0.548171480625511 7.28210971283888e-07 miRNAWalker2_validate -0.220251677402087 3.13850910346967e-06 NA NA NA hsa-miR-27b-3p HYOU1 -0.823491817819754 9.20935302746823e-14 0.537023010893351 1.5998399781904e-06 MirTarget -0.106166853931173 0.0295056089900917 NA NA NA hsa-miR-455-3p HYOU1 -1.3998033821095 5.72010709806871e-17 0.537023010893351 1.5998399781904e-06 miRNAWalker2_validate -0.141259691323468 7.20056604543186e-06 NA NA NA hsa-miR-30b-5p ICK -0.54056186708617 2.44688760798341e-05 0.39119996904083 0.0104331872491703 MirTarget;miRNATAP -0.186572512156452 0.00126546589457456 NA NA NA hsa-miR-27b-3p ICOS -0.823491817819754 9.20935302746823e-14 0.273488185914632 0.356367830019625 miRNATAP -0.333247361615304 0.00906260480427004 NA NA NA hsa-miR-30c-5p ICOS -0.432111642767632 0.000159764714931007 0.273488185914632 0.356367830019625 miRNATAP -0.261323708091759 0.0388023665128044 NA NA NA hsa-miR-181b-5p ICOSLG 0.488256489401108 0.00105321129419701 -0.163710799030457 0.19950923039572 mirMAP -0.106120789669614 0.01071932015251 NA NA NA hsa-miR-192-5p ID1 -0.50188499512787 0.00344713341196035 -2.25178919025733 7.10820515452733e-23 miRNAWalker2_validate -0.14911812571484 0.0297833314669114 NA NA NA hsa-miR-192-5p ID4 -0.50188499512787 0.00344713341196035 -1.27298671386794 2.11782253912459e-06 miRNAWalker2_validate -0.512916510271531 9.38394493873178e-12 NA NA NA hsa-miR-30b-5p IDE -0.54056186708617 2.44688760798341e-05 -0.200075987210792 0.103159271121246 mirMAP -0.204340997702815 9.36222441144209e-06 NA NA NA hsa-miR-181a-5p IDH1 0.250113435902954 0.0551933249319293 -0.49663722146977 7.27088438098223e-06 MirTarget -0.343310160964314 1.63457906957726e-17 NA NA NA hsa-miR-181b-5p IDH1 0.488256489401108 0.00105321129419701 -0.49663722146977 7.27088438098223e-06 MirTarget -0.319164967831864 5.02985148736607e-20 NA NA NA hsa-miR-15a-5p IDH3A 0.349521211668244 0.000770735998804736 -0.233384049804163 0.00744794647062206 MirTarget -0.197497303895338 1.16634819442542e-06 NA NA NA hsa-miR-455-5p IDO1 -0.270546034117157 0.0581320703577731 0.412434143528648 0.186823693040647 miRanda -0.383797409200904 0.000317900495266747 NA NA NA hsa-miR-181a-5p IDO2 0.250113435902954 0.0551933249319293 -3.78490609470101 1.79547840614059e-19 mirMAP -0.540921903789244 0.00101447358856196 NA NA NA hsa-miR-181b-5p IDO2 0.488256489401108 0.00105321129419701 -3.78490609470101 1.79547840614059e-19 mirMAP -0.644793744552967 5.90364961076955e-06 NA NA NA hsa-miR-21-5p IDS 1.51084295924322 1.54551622173259e-34 -0.546753809841531 7.44193151771148e-07 mirMAP -0.101285486064705 0.0129830877855469 NA NA NA hsa-miR-192-3p IFFO2 -0.6401165114007 0.000266272092403814 0.3561399548351 0.00984902835621805 MirTarget -0.230151377846229 8.20115405151137e-10 NA NA NA hsa-miR-30e-5p IFFO2 -0.627815042856657 3.02205690184908e-10 0.3561399548351 0.00984902835621805 MirTarget -0.15560166728368 0.0199247209159833 NA NA NA hsa-miR-455-5p IFI44 -0.270546034117157 0.0581320703577731 -0.587571392595048 0.00856160308374098 miRanda -0.248210057174613 0.00118904072895814 NA NA NA hsa-miR-192-5p IFI44L -0.50188499512787 0.00344713341196035 -1.13811753747565 2.78017749792184e-05 MirTarget -0.226011440432251 0.00360269962780545 NA NA NA hsa-miR-19b-3p IFI44L 0.601279551368824 0.00016685097085251 -1.13811753747565 2.78017749792184e-05 MirTarget -0.234972243137517 0.00474974803169652 NA NA NA hsa-miR-17-3p IFIT5 0.410352776142368 0.00422200500748636 -0.481786761801999 5.45862252534383e-06 MirTarget -0.103785312805045 0.0042495428041671 NA NA NA hsa-miR-181b-5p IFNGR1 0.488256489401108 0.00105321129419701 -0.35955884207507 0.0116826908041428 miRNAWalker2_validate -0.265113774857758 7.56869583693282e-09 NA NA NA hsa-miR-192-5p IFRD1 -0.50188499512787 0.00344713341196035 0.558738711971646 9.00080994709618e-08 miRNAWalker2_validate -0.10932125958836 0.000256365878437799 NA NA NA hsa-miR-148a-3p IGDCC4 -0.748702855596996 3.93313343865641e-07 1.73062068710294 1.15353341113415e-06 miRNATAP -1.10203964346989 5.8953450678023e-23 NA NA NA hsa-miR-192-5p IGDCC4 -0.50188499512787 0.00344713341196035 1.73062068710294 1.15353341113415e-06 miRNAWalker2_validate;miRNATAP -0.738565967026633 1.03875864248912e-13 NA NA NA hsa-miR-215-5p IGDCC4 -0.981544773246509 3.14452272477156e-05 1.73062068710294 1.15353341113415e-06 miRNAWalker2_validate -0.26682172368439 0.000286643094883414 NA NA NA hsa-miR-181a-5p IGF1 0.250113435902954 0.0551933249319293 -3.09093589123239 2.87389370715384e-21 mirMAP -0.504463915639783 8.50109868625984e-05 NA NA NA hsa-miR-181b-5p IGF1 0.488256489401108 0.00105321129419701 -3.09093589123239 2.87389370715384e-21 mirMAP -0.623738116833257 1.69561535563835e-08 NA NA NA hsa-miR-19b-3p IGF1 0.601279551368824 0.00016685097085251 -3.09093589123239 2.87389370715384e-21 MirTarget -0.48361890440052 2.97870836726975e-06 NA NA NA hsa-miR-409-3p IGF1 -0.499649792570937 0.0526751181520117 -3.09093589123239 2.87389370715384e-21 PITA -0.129530044963349 0.0462392123008723 NA NA NA hsa-miR-146b-5p IGF1R 0.419719546795449 0.0457375823220155 -0.704819576268303 0.00353845530141102 miRanda -0.13076910673127 0.0201657634972399 NA NA NA hsa-miR-15a-5p IGF1R 0.349521211668244 0.000770735998804736 -0.704819576268303 0.00353845530141102 miRNATAP -0.46922259656765 3.61522699850867e-05 NA NA NA hsa-miR-192-5p IGF1R -0.50188499512787 0.00344713341196035 -0.704819576268303 0.00353845530141102 miRNAWalker2_validate -0.5797159058919 1.53799651190084e-18 NA NA NA hsa-miR-194-5p IGF1R -0.292530160992458 0.0996141384876663 -0.704819576268303 0.00353845530141102 miRNAWalker2_validate;miRTarBase;miRNATAP -0.583365945764816 5.17802935579868e-20 NA NA NA hsa-miR-34a-5p IGF1R 1.03694231790865 5.74864019540594e-14 -0.704819576268303 0.00353845530141102 miRNAWalker2_validate -0.278122778996491 0.000818572922363686 NA NA NA hsa-miR-455-5p IGF1R -0.270546034117157 0.0581320703577731 -0.704819576268303 0.00353845530141102 miRNATAP -0.33649940148595 4.6083750392036e-05 NA NA NA hsa-miR-99a-5p IGF1R -1.51481656384839 3.93230057259529e-14 -0.704819576268303 0.00353845530141102 miRNAWalker2_validate;miRTarBase;miRNATAP -0.199500914226479 0.00046535126029909 22425712 Furthermore ectopic transfection of miR-99 family members down-regulated the expression of insulin-like growth factor 1 receptor IGF1R and mechanistic target of rapamycin mTOR genes; The deregulation of miR-99 family contributes to the tumorigenesis of HNSCC in part by targeting IGF1R and mTOR signaling pathways tumorigenesis head and neck cancer hsa-miR-224-3p IGF2 1.40770116795301 1.31426607144612e-08 -3.69294069874179 5.99403820984858e-10 mirMAP -0.398994767968095 0.000807606270339222 NA NA NA hsa-miR-34a-5p IGF2 1.03694231790865 5.74864019540594e-14 -3.69294069874179 5.99403820984858e-10 mirMAP -1.25726555221864 9.83117679327442e-10 NA NA NA hsa-miR-455-5p IGF2BP3 -0.270546034117157 0.0581320703577731 2.42884018072337 1.74029814218083e-12 miRanda -0.284468833489169 0.0191323830855379 NA NA NA hsa-miR-34a-5p IGFBP3 1.03694231790865 5.74864019540594e-14 -2.55803658929415 1.7955269745611e-33 miRNATAP -0.464959768400917 2.32405323398958e-09 NA NA NA hsa-miR-146b-5p IGFBP5 0.419719546795449 0.0457375823220155 -0.795485319301285 0.00081396472061437 MirTarget;PITA;miRanda -0.194009384147851 0.000440329216885059 NA NA NA hsa-miR-192-3p IGFBP5 -0.6401165114007 0.000266272092403814 -0.795485319301285 0.00081396472061437 mirMAP -0.516493696791001 5.3518338796442e-16 NA NA NA hsa-miR-34a-5p IGFBP5 1.03694231790865 5.74864019540594e-14 -0.795485319301285 0.00081396472061437 mirMAP -0.162641698295568 0.0478669300696209 NA NA NA hsa-miR-455-5p IGFBP5 -0.270546034117157 0.0581320703577731 -0.795485319301285 0.00081396472061437 mirMAP -0.365786200939905 6.55271541022911e-06 NA NA NA hsa-miR-182-5p IGSF10 1.96601340710222 4.39326175603633e-09 -2.2164252355052 2.87605968192535e-13 MirTarget -0.173125470678718 9.6220895704877e-05 NA NA NA hsa-miR-20a-5p IGSF10 0.854326758727003 5.04256669663285e-07 -2.2164252355052 2.87605968192535e-13 MirTarget -0.493427501413456 1.62841933417548e-08 NA NA NA hsa-miR-30b-5p IKBIP -0.54056186708617 2.44688760798341e-05 0.54383327628486 7.47709800185819e-07 MirTarget -0.103194841113154 0.0143228245812707 NA NA NA hsa-miR-30e-5p IKBIP -0.627815042856657 3.02205690184908e-10 0.54383327628486 7.47709800185819e-07 MirTarget -0.115055863207828 0.0323948682832652 NA NA NA hsa-miR-19b-3p IKZF1 0.601279551368824 0.00016685097085251 -0.973272492309265 4.90450525854266e-07 mirMAP -0.140476926166041 0.0184671656234632 NA NA NA hsa-miR-17-3p IKZF2 0.410352776142368 0.00422200500748636 -0.832526663086801 1.47171329778731e-05 MirTarget;miRNATAP -0.332867254637056 3.29519484473874e-07 NA NA NA hsa-miR-192-5p IKZF2 -0.50188499512787 0.00344713341196035 -0.832526663086801 1.47171329778731e-05 MirTarget -0.188022439724816 0.000606109764283179 NA NA NA hsa-miR-20a-5p IKZF2 0.854326758727003 5.04256669663285e-07 -0.832526663086801 1.47171329778731e-05 mirMAP;miRNATAP -0.35339409166984 5.02584205066545e-11 NA NA NA hsa-miR-455-5p IKZF2 -0.270546034117157 0.0581320703577731 -0.832526663086801 1.47171329778731e-05 miRanda -0.361038378475982 3.54969731736823e-08 NA NA NA hsa-miR-455-5p IL10RA -0.270546034117157 0.0581320703577731 -0.991152842155614 4.01017794079741e-08 miRanda -0.295628807328655 2.03411461989517e-06 NA NA NA hsa-miR-455-5p IL12RB1 -0.270546034117157 0.0581320703577731 -0.723342262361193 0.00084365969926356 miRanda -0.336272780541351 5.48057159106083e-06 NA NA NA hsa-miR-148a-3p IL15 -0.748702855596996 3.93313343865641e-07 -0.299033597604689 0.133566104518099 MirTarget -0.360950562564519 1.84990625247238e-08 NA NA NA hsa-miR-192-5p IL15 -0.50188499512787 0.00344713341196035 -0.299033597604689 0.133566104518099 miRNAWalker2_validate -0.307919878200709 3.2482224824806e-08 NA NA NA hsa-miR-19b-3p IL15 0.601279551368824 0.00016685097085251 -0.299033597604689 0.133566104518099 MirTarget -0.248280940020467 3.69036895748539e-05 NA NA NA hsa-miR-455-5p IL16 -0.270546034117157 0.0581320703577731 -0.644605467709487 1.05245329848707e-05 miRanda -0.142650703425917 0.00475344190971947 NA NA NA hsa-miR-15a-5p IL17RA 0.349521211668244 0.000770735998804736 -0.295831383657008 0.00152127733486087 mirMAP -0.129034624814301 0.00333298994511258 NA NA NA hsa-miR-148a-3p IL17RD -0.748702855596996 3.93313343865641e-07 -0.125343297177237 0.609800523271957 miRNATAP -0.82706589585261 2.60537883515387e-28 NA NA NA hsa-miR-192-3p IL17RD -0.6401165114007 0.000266272092403814 -0.125343297177237 0.609800523271957 MirTarget -0.645408546483783 7.81504604281645e-24 NA NA NA hsa-miR-20a-5p IL17RD 0.854326758727003 5.04256669663285e-07 -0.125343297177237 0.609800523271957 miRNATAP -0.175414544830653 0.0116392994031397 NA NA NA hsa-miR-146b-5p IL17RE 0.419719546795449 0.0457375823220155 -0.197032891375348 0.398434231695978 miRanda -0.11137563038922 0.0396397605360286 NA NA NA hsa-miR-17-3p IL1R1 0.410352776142368 0.00422200500748636 -1.01045381057689 4.50684679449702e-13 mirMAP -0.39073755100076 1.02125622521434e-16 NA NA NA hsa-miR-181a-5p IL1R1 0.250113435902954 0.0551933249319293 -1.01045381057689 4.50684679449702e-13 mirMAP -0.2322434157224 1.42776581461954e-05 NA NA NA hsa-miR-181b-5p IL1R1 0.488256489401108 0.00105321129419701 -1.01045381057689 4.50684679449702e-13 mirMAP -0.246016811028355 1.07107101412662e-07 NA NA NA hsa-miR-182-5p IL6R 1.96601340710222 4.39326175603633e-09 -0.197357669964791 0.382548993653367 mirMAP -0.141778275229433 9.03668122661657e-06 NA NA NA hsa-miR-21-5p IL6R 1.51084295924322 1.54551622173259e-34 -0.197357669964791 0.382548993653367 MirTarget;miRNATAP -0.536139043119449 2.87865737326418e-11 NA NA NA hsa-miR-30b-5p IL6R -0.54056186708617 2.44688760798341e-05 -0.197357669964791 0.382548993653367 mirMAP -0.341317440343868 6.08305739490161e-05 NA NA NA hsa-miR-181a-5p IL6ST 0.250113435902954 0.0551933249319293 -1.91925864959166 1.59476897276323e-08 mirMAP -0.323338513042833 0.0127615914833384 NA NA NA hsa-miR-181b-5p IL6ST 0.488256489401108 0.00105321129419701 -1.91925864959166 1.59476897276323e-08 mirMAP -0.297659176110622 0.00837138676157886 NA NA NA hsa-miR-182-5p IL6ST 1.96601340710222 4.39326175603633e-09 -1.91925864959166 1.59476897276323e-08 mirMAP -0.117870096061415 0.0168557568924928 NA NA NA hsa-miR-19b-3p IL6ST 0.601279551368824 0.00016685097085251 -1.91925864959166 1.59476897276323e-08 mirMAP;miRNATAP -0.376995076356605 0.000315925805068915 NA NA NA hsa-miR-21-5p IL6ST 1.51084295924322 1.54551622173259e-34 -1.91925864959166 1.59476897276323e-08 mirMAP -0.643707080430308 2.44682283240179e-07 NA NA NA hsa-miR-455-5p IL6ST -0.270546034117157 0.0581320703577731 -1.91925864959166 1.59476897276323e-08 miRanda -0.381028018243511 0.0012613423948231 NA NA NA hsa-miR-132-3p IMPA1 0.323796239695997 0.00272093067935091 0.146295288091457 0.151619231073233 miRNAWalker2_validate -0.157324836051075 0.000625777097837605 NA NA NA hsa-miR-20a-5p IMPAD1 0.854326758727003 5.04256669663285e-07 0.0533427265900235 0.638136857901558 mirMAP -0.150802121945985 2.00212787075724e-06 NA NA NA hsa-miR-20b-5p IMPAD1 0.457668023910379 0.0285865211936156 0.0533427265900235 0.638136857901558 mirMAP -0.107398602387183 4.05093470349262e-05 NA NA NA hsa-miR-29c-3p IMPDH1 -1.4367517608807 1.61767774905781e-21 0.476220983398472 0.0158470858835824 miRNATAP -0.164672531135253 0.00681118300318764 NA NA NA hsa-miR-146b-5p ING1 0.419719546795449 0.0457375823220155 -0.116479586429514 0.275983652977486 miRanda -0.102652740508016 2.90335783622004e-05 NA NA NA hsa-miR-21-5p ING3 1.51084295924322 1.54551622173259e-34 -0.222016692366606 0.0136456256313062 MirTarget -0.175389774794838 5.94720107713985e-08 NA NA NA hsa-miR-29c-3p ING5 -1.4367517608807 1.61767774905781e-21 0.66784229641384 8.47792755654136e-13 mirMAP -0.207105943574425 5.33588087844621e-13 NA NA NA hsa-miR-34a-5p INHBB 1.03694231790865 5.74864019540594e-14 -0.716094510918822 0.000267948992937716 miRNATAP -0.284301776707405 2.5200278912638e-05 NA NA NA hsa-miR-181b-5p INO80B 0.488256489401108 0.00105321129419701 0.305267589114463 0.00479261589444966 miRNAWalker2_validate -0.13998065014107 6.91260218894386e-05 NA NA NA hsa-miR-192-3p INPP4A -0.6401165114007 0.000266272092403814 0.227138590990355 0.0155254726733909 mirMAP -0.210676550771265 2.86107728101967e-17 NA NA NA hsa-miR-455-5p INPP4A -0.270546034117157 0.0581320703577731 0.227138590990355 0.0155254726733909 miRanda -0.199215607775977 2.44500137153382e-10 NA NA NA hsa-miR-192-5p INPP5F -0.50188499512787 0.00344713341196035 0.439943780947461 4.31972239513017e-05 miRNAWalker2_validate -0.103055734867059 0.000758763205060818 NA NA NA hsa-miR-30c-5p INPP5F -0.432111642767632 0.000159764714931007 0.439943780947461 4.31972239513017e-05 miRNAWalker2_validate -0.136631609525863 0.00301586344256785 NA NA NA hsa-miR-27b-3p INPP5J -0.823491817819754 9.20935302746823e-14 1.51506447952545 5.95748863803298e-08 MirTarget;miRNATAP -0.52432642880818 1.61041876223075e-05 NA NA NA hsa-miR-27b-3p INPPL1 -0.823491817819754 9.20935302746823e-14 0.555628121445383 3.47480233047265e-10 miRNAWalker2_validate -0.152672935300165 7.7793998638279e-05 NA NA NA hsa-miR-182-5p INSIG1 1.96601340710222 4.39326175603633e-09 -0.982451848864065 0.000118571254506076 MirTarget;miRNATAP -0.193464154309233 8.98280893373766e-08 NA NA NA hsa-miR-19b-3p INSIG1 0.601279551368824 0.00016685097085251 -0.982451848864065 0.000118571254506076 MirTarget -0.19698523635569 0.0117232856937852 NA NA NA hsa-miR-20a-5p INSIG1 0.854326758727003 5.04256669663285e-07 -0.982451848864065 0.000118571254506076 miRNAWalker2_validate -0.197841600566252 0.00661179328132122 NA NA NA hsa-miR-221-3p INSIG1 1.12244756358612 3.48370308238012e-13 -0.982451848864065 0.000118571254506076 MirTarget;miRNATAP -0.66232636123501 2.64292654726766e-18 NA NA NA hsa-miR-222-3p INSIG1 1.08574156066353 1.76407192348131e-11 -0.982451848864065 0.000118571254506076 MirTarget;miRNATAP -0.688405183879528 1.52661242944454e-21 NA NA NA hsa-miR-409-3p INSIG1 -0.499649792570937 0.0526751181520117 -0.982451848864065 0.000118571254506076 PITA -0.133830578686282 0.00580373562496458 NA NA NA hsa-miR-15a-5p INSR 0.349521211668244 0.000770735998804736 -0.278293402111066 0.00785689311731476 miRNATAP -0.251138215261527 2.59574923914891e-07 NA NA NA hsa-miR-181a-5p INSR 0.250113435902954 0.0551933249319293 -0.278293402111066 0.00785689311731476 mirMAP -0.196102420475405 4.52506455097139e-07 NA NA NA hsa-miR-181b-5p INSR 0.488256489401108 0.00105321129419701 -0.278293402111066 0.00785689311731476 mirMAP -0.192792987659091 1.02091731606267e-08 NA NA NA hsa-miR-21-5p INSR 1.51084295924322 1.54551622173259e-34 -0.278293402111066 0.00785689311731476 mirMAP -0.133506275914425 0.00045620211593194 24804226;27220494;21618027 Downregulation of miR-21 in radioresistant NSCLC A549 cells inhibited the colony-forming ability and proliferation of A549 cells after IR; Moreover silencing miR-21 enhanced apoptosis of A549 cells induced by IR accompanied by decreased phosphorylated-Akt protein level; However PI3K activator IGF-1 reversed suppression of phosphorylated-Akt protein level and promotion of apoptosis of A549 cells after IR caused by miR-21 knockdown; Silencing miR-21 in radioresistant NSCLC A549 cells sensitized them to IR by inhibiting cell proliferation and enhancing cell apoptosis through inhibition of PI3K/Akt signaling pathway;In addition we also demonstrated that miR-21 confers decreased autophagy in cervical cancer cells after IR via the Akt-mTOR signaling pathway;In this study we found that miR-21 expression was upregulated in response to ionizing radiation IR in U251 cells which suggested that miR-21 could be involved in the response of U251 cells to radiation; We showed that a miR-21 inhibitor enhanced IR-induced glioblastoma cell growth arrest and increased the level of apoptosis which was probably caused by abrogation of the G2-M arrest induced by IR ;;drug resistance lung squamous cell cancer;cervical and endocervical cancer;glioblastoma hsa-miR-34a-5p INTS10 1.03694231790865 5.74864019540594e-14 -0.911806061839416 2.64382448557783e-22 miRNAWalker2_validate -0.144207690883047 1.87060265287911e-05 NA NA NA hsa-miR-455-5p INTS2 -0.270546034117157 0.0581320703577731 0.206931247919083 0.0805086423763968 PITA;miRanda -0.125040935417863 0.00197679078111102 NA NA NA hsa-miR-21-5p INTS6 1.51084295924322 1.54551622173259e-34 -0.650926189132886 9.71819582580471e-11 MirTarget -0.226990475333205 6.77043846342216e-10 NA NA NA hsa-miR-29c-3p IP6K1 -1.4367517608807 1.61767774905781e-21 0.889516693961123 4.04556190796781e-31 mirMAP -0.173259703292971 2.47912460185569e-12 NA NA NA hsa-miR-192-3p IPCEF1 -0.6401165114007 0.000266272092403814 -1.26877539036323 2.25222478955899e-10 mirMAP -0.228377610109421 4.80321290224465e-05 NA NA NA hsa-miR-194-5p IPCEF1 -0.292530160992458 0.0996141384876663 -1.26877539036323 2.25222478955899e-10 mirMAP -0.261952780410025 2.54668746322098e-06 NA NA NA hsa-miR-30b-5p IPMK -0.54056186708617 2.44688760798341e-05 -0.810745253988053 0.00209768104745479 mirMAP -0.241925124512285 0.0159910416934735 NA NA NA hsa-miR-15a-5p IPO7 0.349521211668244 0.000770735998804736 -0.12637692697336 0.126888447462856 MirTarget;miRNATAP -0.122314221806651 0.00159634774363724 NA NA NA hsa-miR-21-5p IPP 1.51084295924322 1.54551622173259e-34 -0.117789097974411 0.331754038056184 miRNAWalker2_validate -0.149850091403392 0.000668566581290115 NA NA NA hsa-miR-222-3p IPP 1.08574156066353 1.76407192348131e-11 -0.117789097974411 0.331754038056184 miRNAWalker2_validate -0.129615439258099 0.000268523246040146 NA NA NA hsa-miR-148a-3p IQCE -0.748702855596996 3.93313343865641e-07 1.21246761004316 4.22270897620511e-25 mirMAP -0.303477931958815 1.30626379135067e-14 NA NA NA hsa-miR-27b-3p IQCE -0.823491817819754 9.20935302746823e-14 1.21246761004316 4.22270897620511e-25 mirMAP -0.3250397712002 6.36489964936852e-10 NA NA NA hsa-miR-181a-5p IQCG 0.250113435902954 0.0551933249319293 0.47868225374327 0.000401976880621517 miRNAWalker2_validate -0.125556079500173 0.0138915021199967 NA NA NA hsa-miR-455-5p IQCK -0.270546034117157 0.0581320703577731 -0.0389884438836998 0.750066533012186 miRanda -0.136304348768808 0.00107645926119846 NA NA NA hsa-miR-192-5p IQGAP1 -0.50188499512787 0.00344713341196035 -0.355040840395703 0.0117780874619327 miRNAWalker2_validate -0.412627864720223 2.8039612101239e-28 NA NA NA hsa-miR-455-3p IQGAP1 -1.3998033821095 5.72010709806871e-17 -0.355040840395703 0.0117780874619327 miRNATAP -0.224712459484214 8.26016413642689e-09 NA NA NA hsa-miR-455-5p IQGAP1 -0.270546034117157 0.0581320703577731 -0.355040840395703 0.0117780874619327 miRanda -0.381033796369613 3.13563319012239e-16 NA NA NA hsa-miR-181a-5p IQGAP2 0.250113435902954 0.0551933249319293 -1.09691498655628 9.21601276995956e-14 miRNATAP -0.385146318006949 4.24629584152863e-12 NA NA NA hsa-miR-181b-5p IQGAP2 0.488256489401108 0.00105321129419701 -1.09691498655628 9.21601276995956e-14 miRNATAP -0.41433641854952 3.04425917921197e-18 NA NA NA hsa-miR-20a-5p IQSEC2 0.854326758727003 5.04256669663285e-07 -0.48464253606929 0.00305618147119171 miRNATAP -0.214829748320562 3.15454494462766e-06 NA NA NA hsa-miR-34a-5p IQSEC2 1.03694231790865 5.74864019540594e-14 -0.48464253606929 0.00305618147119171 mirMAP -0.205197694858938 0.000258773373741608 NA NA NA hsa-miR-224-3p IRAK3 1.40770116795301 1.31426607144612e-08 -1.13497721915457 1.79851071172739e-09 mirMAP -0.128614239192543 0.000620367595349101 NA NA NA hsa-miR-21-5p IREB2 1.51084295924322 1.54551622173259e-34 -0.370291061083076 1.38083203196362e-05 miRNAWalker2_validate -0.224298460304271 1.56840495630729e-13 NA NA NA hsa-miR-30b-5p IREB2 -0.54056186708617 2.44688760798341e-05 -0.370291061083076 1.38083203196362e-05 mirMAP -0.135015943039963 2.85505995820922e-05 NA NA NA hsa-miR-20a-5p IRF1 0.854326758727003 5.04256669663285e-07 -0.472051826973738 0.000392981425099119 MirTarget;miRNATAP -0.145650844922923 0.000113175393896431 NA NA NA hsa-miR-20a-5p IRF2 0.854326758727003 5.04256669663285e-07 -0.488730264470989 9.63225888653794e-08 miRTarBase -0.136935477498102 1.30952208570594e-07 NA NA NA hsa-miR-221-3p IRF2 1.12244756358612 3.48370308238012e-13 -0.488730264470989 9.63225888653794e-08 miRNATAP -0.127838277330377 6.17003025135955e-06 24607843 Survival in patients with high risk prostate cancer is predicted by miR 221 which regulates proliferation apoptosis and invasion of prostate cancer cells by inhibiting IRF2 and SOCS3; miR-221 directly inhibits the expression of SOCS3 and IRF2 two oncogenes that negatively regulate this signaling pathway poor survival prostate cancer hsa-miR-222-3p IRF2 1.08574156066353 1.76407192348131e-11 -0.488730264470989 9.63225888653794e-08 miRNATAP -0.123180795364565 5.62604077427923e-06 NA NA NA hsa-miR-29c-3p IRGQ -1.4367517608807 1.61767774905781e-21 0.902560453855328 7.48220981072122e-23 miRNAWalker2_validate;mirMAP -0.238042740843245 1.00474853280956e-16 NA NA NA hsa-miR-30c-5p IRGQ -0.432111642767632 0.000159764714931007 0.902560453855328 7.48220981072122e-23 mirMAP -0.113690694644874 0.00572722330253046 NA NA NA hsa-miR-30e-5p IRGQ -0.627815042856657 3.02205690184908e-10 0.902560453855328 7.48220981072122e-23 mirMAP -0.1867839098515 5.77468804728046e-05 NA NA NA hsa-miR-505-5p IRGQ -0.768282569967001 1.14662846595407e-05 0.902560453855328 7.48220981072122e-23 MirTarget -0.112972138579469 1.99803380767852e-05 NA NA NA hsa-miR-30b-5p IRS1 -0.54056186708617 2.44688760798341e-05 -0.221383948238947 0.137544848662312 MirTarget -0.185037722193096 0.0010185231802762 NA NA NA hsa-miR-181a-5p IRS2 0.250113435902954 0.0551933249319293 -0.811999517586244 8.14991854093828e-06 MirTarget;miRNATAP -0.419606989102411 5.79905601535079e-10 NA NA NA hsa-miR-181b-5p IRS2 0.488256489401108 0.00105321129419701 -0.811999517586244 8.14991854093828e-06 MirTarget;miRNATAP -0.464615763465426 1.1767859809815e-15 NA NA NA hsa-miR-214-5p IRX5 -1.91497809567701 3.92955595018147e-12 1.62223830123616 2.57949821198748e-06 miRNATAP -0.142173869086214 0.0195751531417681 NA NA NA hsa-miR-29c-3p ISG20L2 -1.4367517608807 1.61767774905781e-21 0.431482815078771 1.97782524980892e-06 MirTarget -0.136417401892395 9.87943257707832e-07 NA NA NA hsa-miR-15a-5p ISLR 0.349521211668244 0.000770735998804736 -1.90334320627613 1.64319359637083e-06 MirTarget;miRNATAP -0.832079623475006 9.67208172039549e-06 NA NA NA hsa-miR-652-3p ISOC1 0.135945800164278 0.391695970197646 -1.02099310117376 3.33401744444869e-18 miRNAWalker2_validate -0.107781406518802 0.00422044700482599 NA NA NA hsa-miR-34a-5p ITCH 1.03694231790865 5.74864019540594e-14 -0.763511552009159 4.85301452017852e-17 miRNATAP -0.138877886026545 1.60936214078016e-05 NA NA NA hsa-miR-20a-5p ITFG1 0.854326758727003 5.04256669663285e-07 -0.564982310127911 9.74861515129265e-07 MirTarget -0.232001532273386 5.5697974058041e-13 NA NA NA hsa-miR-20b-5p ITFG1 0.457668023910379 0.0285865211936156 -0.564982310127911 9.74861515129265e-07 MirTarget -0.110563023541762 4.22969671594383e-05 NA NA NA hsa-miR-181a-5p ITGA1 0.250113435902954 0.0551933249319293 -0.675046465429795 1.83477212641831e-07 mirMAP -0.159557519521478 0.00116192713555786 NA NA NA hsa-miR-181b-5p ITGA1 0.488256489401108 0.00105321129419701 -0.675046465429795 1.83477212641831e-07 mirMAP -0.17356111081698 4.57364400546711e-05 NA NA NA hsa-miR-21-5p ITGA1 1.51084295924322 1.54551622173259e-34 -0.675046465429795 1.83477212641831e-07 mirMAP -0.324725552717668 3.57684105241524e-12 NA NA NA hsa-miR-15a-5p ITGA2 0.349521211668244 0.000770735998804736 1.53120134028147 5.03620431516659e-09 MirTarget;miRNATAP -0.285589628102852 0.0233184893759413 NA NA NA hsa-miR-19b-3p ITGA2 0.601279551368824 0.00016685097085251 1.53120134028147 5.03620431516659e-09 MirTarget -0.34350775357453 2.00709629618829e-05 NA NA NA hsa-miR-27b-3p ITGA2 -0.823491817819754 9.20935302746823e-14 1.53120134028147 5.03620431516659e-09 miRNATAP -0.648959489127879 1.00730961424074e-08 NA NA NA hsa-miR-30b-5p ITGA2 -0.54056186708617 2.44688760798341e-05 1.53120134028147 5.03620431516659e-09 mirMAP -0.22382877707025 0.0271687178126922 NA NA NA hsa-miR-30c-5p ITGA2 -0.432111642767632 0.000159764714931007 1.53120134028147 5.03620431516659e-09 mirMAP -0.374655382724916 0.000961645145926353 NA NA NA hsa-miR-30e-5p ITGA2 -0.627815042856657 3.02205690184908e-10 1.53120134028147 5.03620431516659e-09 mirMAP -0.737206572787374 6.45205020884361e-09 NA NA NA hsa-miR-455-5p ITGA3 -0.270546034117157 0.0581320703577731 0.331189713134492 0.166738416790431 miRanda -0.470158293658707 5.65979836634134e-09 NA NA NA hsa-miR-455-5p ITGA4 -0.270546034117157 0.0581320703577731 -0.792197018745433 7.52858458455927e-05 miRanda -0.38475521770215 1.5530233128954e-08 NA NA NA hsa-miR-148a-3p ITGA5 -0.748702855596996 3.93313343865641e-07 0.471634888877482 5.29697754708897e-05 miRNATAP -0.307894492928595 8.35158872292536e-17 NA NA NA hsa-miR-27b-3p ITGA5 -0.823491817819754 9.20935302746823e-14 0.471634888877482 5.29697754708897e-05 miRNATAP -0.10096527373625 0.0463620780367348 NA NA NA hsa-miR-30b-5p ITGA8 -0.54056186708617 2.44688760798341e-05 -0.339101571383565 0.266122133539954 mirMAP -0.318911170549572 0.005761661684469 NA NA NA hsa-miR-194-5p ITGA9 -0.292530160992458 0.0996141384876663 -2.64633266303169 2.99434757393029e-24 miRNAWalker2_validate;miRTarBase -0.292723578816099 0.000106994877245331 NA NA NA hsa-miR-192-5p ITGAV -0.50188499512787 0.00344713341196035 0.42083458357731 0.00760476174317356 miRNAWalker2_validate;MirTarget -0.344370980466671 1.89013250176103e-15 NA NA NA hsa-miR-192-5p ITGB1 -0.50188499512787 0.00344713341196035 0.150635638369529 0.0875061080940868 miRNAWalker2_validate -0.159167916481672 6.60024481999039e-11 NA NA NA hsa-miR-146b-5p ITGB3 0.419719546795449 0.0457375823220155 -0.984722780911358 0.000225186373225592 miRanda -0.209405714984689 0.000753494487303087 NA NA NA hsa-miR-221-3p ITGB3 1.12244756358612 3.48370308238012e-13 -0.984722780911358 0.000225186373225592 MirTarget -0.386235530184791 2.395985878903e-06 NA NA NA hsa-miR-222-3p ITGB3 1.08574156066353 1.76407192348131e-11 -0.984722780911358 0.000225186373225592 MirTarget -0.292691325646809 0.000210297407328954 NA NA NA hsa-miR-30b-5p ITGB3 -0.54056186708617 2.44688760798341e-05 -0.984722780911358 0.000225186373225592 mirMAP -0.338348015277282 0.000871538256799819 20498642 Enforced constitutive expression of mir-30 in BT-ICs inhibits their self-renewal capacity by reducing Ubc9 and induces apoptosis through silencing ITGB3 breast cancer hsa-miR-148a-3p ITGB8 -0.748702855596996 3.93313343865641e-07 -2.87006066676904 1.87352126528694e-11 miRNATAP -1.14663315826581 1.03967657771964e-16 NA NA NA hsa-miR-19b-3p ITGB8 0.601279551368824 0.00016685097085251 -2.87006066676904 1.87352126528694e-11 MirTarget -0.397676292718566 0.00280329871319981 NA NA NA hsa-miR-20a-5p ITGB8 0.854326758727003 5.04256669663285e-07 -2.87006066676904 1.87352126528694e-11 MirTarget;miRNATAP -0.630843134227604 2.80236468955331e-07 NA NA NA hsa-miR-17-3p ITIH5 0.410352776142368 0.00422200500748636 -0.952871722270784 0.01107843189207 MirTarget -0.463350909757877 0.000276269725710872 NA NA NA hsa-miR-30c-5p ITPK1 -0.432111642767632 0.000159764714931007 0.275782540430693 0.0156122837519687 miRNATAP -0.116423438869167 0.0166659641090024 NA NA NA hsa-miR-194-5p ITPKB -0.292530160992458 0.0996141384876663 -0.0511821105190662 0.685499623217908 MirTarget;miRNATAP -0.27059980872147 5.88566940399985e-16 NA NA NA hsa-miR-34a-5p ITPKB 1.03694231790865 5.74864019540594e-14 -0.0511821105190662 0.685499623217908 mirMAP -0.107304407128448 0.0132216455639376 NA NA NA hsa-miR-455-5p ITPKB -0.270546034117157 0.0581320703577731 -0.0511821105190662 0.685499623217908 miRanda -0.191778136893188 7.48960773349679e-06 NA NA NA hsa-miR-15a-5p ITPR1 0.349521211668244 0.000770735998804736 -0.089448027293932 0.599627751005593 MirTarget;miRNATAP -0.257780475520877 0.0012664970833331 NA NA NA hsa-miR-19b-3p ITPR1 0.601279551368824 0.00016685097085251 -0.089448027293932 0.599627751005593 MirTarget;miRNATAP -0.181571040850891 0.000422672677535174 NA NA NA hsa-miR-30e-5p ITPRIPL2 -0.627815042856657 3.02205690184908e-10 0.0229178174980973 0.835912409983391 mirMAP -0.144370678997762 0.00672706813871226 NA NA NA hsa-miR-181a-5p ITSN1 0.250113435902954 0.0551933249319293 -0.745784549212654 1.16990524702238e-11 miRNATAP -0.16543437503213 8.28442787576848e-05 NA NA NA hsa-miR-181b-5p ITSN1 0.488256489401108 0.00105321129419701 -0.745784549212654 1.16990524702238e-11 miRNATAP -0.173554622209751 1.86588371838655e-06 NA NA NA hsa-miR-503-5p IVD 0.191949282338049 0.268420664548092 -1.41104888737809 2.44327162766251e-25 miRNAWalker2_validate -0.197327093128132 9.13838319363573e-07 NA NA NA hsa-miR-194-5p IVNS1ABP -0.292530160992458 0.0996141384876663 0.0567700023028399 0.581179227213777 MirTarget -0.134394746183759 1.43874307370665e-06 NA NA NA hsa-miR-455-5p IVNS1ABP -0.270546034117157 0.0581320703577731 0.0567700023028399 0.581179227213777 PITA;miRanda -0.117115027780058 0.000821427420813228 NA NA NA hsa-miR-181a-5p IYD 0.250113435902954 0.0551933249319293 -2.66179429977146 1.10383788101266e-13 mirMAP -0.572757098599121 3.30496647851301e-05 NA NA NA hsa-miR-181b-5p IYD 0.488256489401108 0.00105321129419701 -2.66179429977146 1.10383788101266e-13 mirMAP -0.686501158073007 7.68640272104804e-09 NA NA NA hsa-miR-182-5p IYD 1.96601340710222 4.39326175603633e-09 -2.66179429977146 1.10383788101266e-13 mirMAP -0.218885326938713 2.93891085987375e-05 NA NA NA hsa-miR-20a-5p IYD 0.854326758727003 5.04256669663285e-07 -2.66179429977146 1.10383788101266e-13 mirMAP -0.237042121408097 0.0238526235056877 NA NA NA hsa-miR-20b-5p IYD 0.457668023910379 0.0285865211936156 -2.66179429977146 1.10383788101266e-13 mirMAP -0.383196413318734 7.32299132931178e-06 NA NA NA hsa-miR-34a-5p JAG1 1.03694231790865 5.74864019540594e-14 0.284179809900906 0.0962289282729052 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.193173900876987 0.000964941592670474 NA NA NA hsa-miR-30c-5p JAG2 -0.432111642767632 0.000159764714931007 1.63935349038013 5.44903322246813e-19 miRNATAP -0.210976309334387 0.0101568475600097 NA NA NA hsa-miR-20a-5p JAK1 0.854326758727003 5.04256669663285e-07 -0.491502741052473 2.21647945606145e-08 MirTarget -0.23386116447226 1.56734608485868e-22 NA NA NA hsa-miR-455-5p JAK1 -0.270546034117157 0.0581320703577731 -0.491502741052473 2.21647945606145e-08 miRanda -0.167977882302863 2.26382130466332e-08 NA NA NA hsa-miR-30b-5p JAKMIP2 -0.54056186708617 2.44688760798341e-05 -0.850250373285728 0.00348445584858937 MirTarget -0.35849230248022 0.00118052807345266 NA NA NA hsa-miR-455-5p JAKMIP3 -0.270546034117157 0.0581320703577731 0.614477041005658 0.0377460459947292 miRanda -0.488590700053212 1.14168394115123e-06 NA NA NA hsa-miR-19b-3p JAM2 0.601279551368824 0.00016685097085251 -0.411475049759854 0.068165395262772 miRNATAP -0.204909043520286 0.00277385519726563 NA NA NA hsa-miR-29c-3p JARID2 -1.4367517608807 1.61767774905781e-21 0.389563833569475 2.66930964150282e-05 MirTarget;miRNATAP -0.187450143768688 2.4296724546674e-11 NA NA NA hsa-miR-181a-5p JAZF1 0.250113435902954 0.0551933249319293 -0.00573099240982522 0.96939333269824 MirTarget;miRNATAP -0.21143825265081 0.000146140309698267 NA NA NA hsa-miR-181b-5p JAZF1 0.488256489401108 0.00105321129419701 -0.00573099240982522 0.96939333269824 MirTarget;miRNATAP -0.20234329165734 2.8445229531137e-05 NA NA NA hsa-miR-19b-3p JAZF1 0.601279551368824 0.00016685097085251 -0.00573099240982522 0.96939333269824 MirTarget -0.139512887225434 0.00202393580906888 NA NA NA hsa-miR-20a-5p JAZF1 0.854326758727003 5.04256669663285e-07 -0.00573099240982522 0.96939333269824 MirTarget;miRNATAP -0.131616971924319 0.00179191886719271 NA NA NA hsa-miR-455-5p JAZF1 -0.270546034117157 0.0581320703577731 -0.00573099240982522 0.96939333269824 miRanda -0.135927196715449 0.00771913307582754 NA NA NA hsa-miR-192-5p JDP2 -0.50188499512787 0.00344713341196035 -1.36060874258205 6.48057311731977e-22 mirMAP -0.117036284044381 0.00555682048555764 NA NA NA hsa-miR-181a-5p JMY 0.250113435902954 0.0551933249319293 -0.0723925290319816 0.482620332419229 MirTarget -0.171984617697118 6.88727446980727e-06 NA NA NA hsa-miR-181b-5p JMY 0.488256489401108 0.00105321129419701 -0.0723925290319816 0.482620332419229 MirTarget -0.190802077897587 7.44084137539522e-09 NA NA NA hsa-miR-21-5p JMY 1.51084295924322 1.54551622173259e-34 -0.0723925290319816 0.482620332419229 miRNAWalker2_validate;mirMAP -0.167929539107582 6.27891328902698e-06 NA NA NA hsa-miR-99a-5p JPH1 -1.51481656384839 3.93230057259529e-14 0.687134640890904 0.0658260491600653 miRNAWalker2_validate -0.4633905647324 1.01264680623323e-07 NA NA NA hsa-miR-455-5p JPH2 -0.270546034117157 0.0581320703577731 0.879979261502041 0.000241987551148797 miRanda -0.310858678228673 0.00015817338010009 NA NA NA hsa-miR-146b-5p KALRN 0.419719546795449 0.0457375823220155 -0.965609985856982 5.18991450299309e-12 miRanda -0.127703443398976 0.000115849795712148 NA NA NA hsa-miR-15a-5p KALRN 0.349521211668244 0.000770735998804736 -0.965609985856982 5.18991450299309e-12 miRNATAP -0.197153708500583 0.00353039130363726 NA NA NA hsa-miR-181a-5p KALRN 0.250113435902954 0.0551933249319293 -0.965609985856982 5.18991450299309e-12 MirTarget -0.196514443607408 0.000251335877912033 NA NA NA hsa-miR-181b-5p KALRN 0.488256489401108 0.00105321129419701 -0.965609985856982 5.18991450299309e-12 MirTarget -0.19836929536185 2.04135961046944e-05 NA NA NA hsa-miR-181a-5p KANK1 0.250113435902954 0.0551933249319293 -0.665033230225995 7.24717327382789e-06 MirTarget;miRNATAP -0.191713927737079 0.000620228446805052 NA NA NA hsa-miR-181b-5p KANK1 0.488256489401108 0.00105321129419701 -0.665033230225995 7.24717327382789e-06 MirTarget;miRNATAP -0.217058069474394 7.57171588042218e-06 NA NA NA hsa-miR-30b-5p KANK1 -0.54056186708617 2.44688760798341e-05 -0.665033230225995 7.24717327382789e-06 mirMAP -0.132770126770298 0.0193801475826463 NA NA NA hsa-miR-181a-5p KAT2B 0.250113435902954 0.0551933249319293 -0.938558773689222 1.89276182546283e-10 miRNAWalker2_validate;miRTarBase;MirTarget -0.426890206635934 6.26669869314588e-15 NA NA NA hsa-miR-181b-5p KAT2B 0.488256489401108 0.00105321129419701 -0.938558773689222 1.89276182546283e-10 miRNAWalker2_validate;miRTarBase;MirTarget -0.457990357788594 9.28981291080347e-23 NA NA NA hsa-miR-19b-3p KAT2B 0.601279551368824 0.00016685097085251 -0.938558773689222 1.89276182546283e-10 miRNAWalker2_validate -0.300580910813304 1.79295987685863e-11 NA NA NA hsa-miR-20a-5p KAT2B 0.854326758727003 5.04256669663285e-07 -0.938558773689222 1.89276182546283e-10 MirTarget -0.323298461721723 5.05244582669315e-15 NA NA NA hsa-miR-20b-5p KAT2B 0.457668023910379 0.0285865211936156 -0.938558773689222 1.89276182546283e-10 MirTarget -0.113158413426819 0.00122118573242313 NA NA NA hsa-miR-19b-3p KATNAL1 0.601279551368824 0.00016685097085251 -0.587180254929299 2.39212781667801e-05 miRNAWalker2_validate;MirTarget -0.211083320614754 5.34692863122888e-07 NA NA NA hsa-miR-20a-5p KATNAL1 0.854326758727003 5.04256669663285e-07 -0.587180254929299 2.39212781667801e-05 MirTarget -0.223397949352903 1.10005459053819e-08 NA NA NA hsa-miR-132-3p KBTBD11 0.323796239695997 0.00272093067935091 -3.69441479326857 5.44862424107513e-27 mirMAP -0.421711394398244 0.0113213027580778 NA NA NA hsa-miR-19b-3p KBTBD11 0.601279551368824 0.00016685097085251 -3.69441479326857 5.44862424107513e-27 mirMAP -0.534142026526822 1.31469672895184e-06 NA NA NA hsa-miR-132-3p KBTBD3 0.323796239695997 0.00272093067935091 -0.0343513010930623 0.719471527797474 miRNAWalker2_validate -0.148819872977134 0.000544874377017218 NA NA NA hsa-miR-21-5p KBTBD6 1.51084295924322 1.54551622173259e-34 -0.188967726777397 0.0378562517960693 miRNAWalker2_validate;MirTarget -0.212823281956273 5.20842909132223e-11 NA NA NA hsa-miR-34a-5p KBTBD6 1.03694231790865 5.74864019540594e-14 -0.188967726777397 0.0378562517960693 miRNAWalker2_validate -0.11063758446177 0.000369951722704658 NA NA NA hsa-miR-181a-5p KBTBD7 0.250113435902954 0.0551933249319293 -0.935413933152499 3.50066588121242e-06 mirMAP -0.185337511409588 0.0155168260463289 NA NA NA hsa-miR-181b-5p KBTBD7 0.488256489401108 0.00105321129419701 -0.935413933152499 3.50066588121242e-06 mirMAP -0.18069132373 0.00663093120544326 NA NA NA hsa-miR-21-5p KBTBD7 1.51084295924322 1.54551622173259e-34 -0.935413933152499 3.50066588121242e-06 miRNAWalker2_validate -0.541976693322973 6.40797115655026e-14 NA NA NA hsa-miR-30b-5p KBTBD7 -0.54056186708617 2.44688760798341e-05 -0.935413933152499 3.50066588121242e-06 mirMAP -0.201877069076263 0.00901396259173298 NA NA NA hsa-miR-19b-3p KBTBD8 0.601279551368824 0.00016685097085251 -0.535277103367331 0.00302109600455283 MirTarget -0.221004443776944 5.36065847835358e-05 NA NA NA hsa-miR-20a-5p KBTBD8 0.854326758727003 5.04256669663285e-07 -0.535277103367331 0.00302109600455283 MirTarget -0.257962681991961 3.69449355423291e-07 NA NA NA hsa-miR-221-3p KBTBD8 1.12244756358612 3.48370308238012e-13 -0.535277103367331 0.00302109600455283 MirTarget -0.196397871725741 0.00040178822828246 NA NA NA hsa-miR-21-5p KCNA3 1.51084295924322 1.54551622173259e-34 -1.97421353774174 1.82123288049626e-13 miRNATAP -0.299637746508877 0.00295778536619722 NA NA NA hsa-miR-146a-5p KCNB1 -0.742958238440575 0.000765983177482633 -1.36493235155488 0.00106428111512555 mirMAP -0.523443888033259 7.67294945919341e-09 NA NA NA hsa-miR-146b-5p KCNB1 0.419719546795449 0.0457375823220155 -1.36493235155488 0.00106428111512555 mirMAP -0.200568718240681 0.0394166256848793 NA NA NA hsa-miR-409-3p KCNB1 -0.499649792570937 0.0526751181520117 -1.36493235155488 0.00106428111512555 mirMAP -0.40335515970234 2.50250214648741e-07 NA NA NA hsa-miR-455-5p KCNC4 -0.270546034117157 0.0581320703577731 0.108924131941052 0.454388838529205 miRanda;miRNATAP -0.12801124989866 0.0100965137463616 NA NA NA hsa-miR-455-3p KCND1 -1.3998033821095 5.72010709806871e-17 -0.0249564005260714 0.880809942248159 PITA;miRNATAP -0.222812174899468 1.38731021527028e-06 NA NA NA hsa-miR-455-5p KCND2 -0.270546034117157 0.0581320703577731 -0.745368636215275 0.015231944197855 miRanda -0.647197526050639 3.9147394683702e-10 NA NA NA hsa-miR-20a-5p KCND3 0.854326758727003 5.04256669663285e-07 -3.73766223806269 5.88031464564806e-19 mirMAP -0.862063091166258 1.26432104813851e-12 NA NA NA hsa-miR-146b-5p KCNE4 0.419719546795449 0.0457375823220155 -0.633866097690669 0.01553835552073 miRanda -0.169088511974383 0.00545187801944862 NA NA NA hsa-miR-20a-5p KCNE4 0.854326758727003 5.04256669663285e-07 -0.633866097690669 0.01553835552073 miRNATAP -0.377494278282656 2.84523868485696e-07 NA NA NA hsa-miR-29c-3p KCNIP2 -1.4367517608807 1.61767774905781e-21 0.363229978109951 0.0425651665921935 miRNATAP -0.139576849321509 0.0114226938755804 NA NA NA hsa-miR-146b-5p KCNIP3 0.419719546795449 0.0457375823220155 0.27585033015965 0.430199672686349 miRNATAP -0.315195355117712 9.23707647257072e-05 NA NA NA hsa-miR-194-5p KCNJ11 -0.292530160992458 0.0996141384876663 0.990681278027291 0.000402851409568322 miRNATAP -0.204303507005661 0.00830833523398844 NA NA NA hsa-miR-505-5p KCNJ11 -0.768282569967001 1.14662846595407e-05 0.990681278027291 0.000402851409568322 MirTarget -0.241373330467845 0.00187909494504296 NA NA NA hsa-miR-146b-5p KCNJ16 0.419719546795449 0.0457375823220155 -4.39686823652343 6.82157843264576e-21 MirTarget;miRanda -0.250122230809615 0.0289572595059475 NA NA NA hsa-miR-19b-3p KCNJ2 0.601279551368824 0.00016685097085251 0.347160694290722 0.0310374060119201 MirTarget;miRNATAP -0.103076230719497 0.0354459042598887 NA NA NA hsa-miR-455-3p KCNJ2 -1.3998033821095 5.72010709806871e-17 0.347160694290722 0.0310374060119201 PITA;miRNATAP -0.102721043285942 0.0232126145623274 NA NA NA hsa-miR-455-5p KCNJ2 -0.270546034117157 0.0581320703577731 0.347160694290722 0.0310374060119201 MirTarget;PITA;miRanda;miRNATAP -0.207622230880354 0.000156435672254614 NA NA NA hsa-miR-17-3p KCNJ5 0.410352776142368 0.00422200500748636 1.40144080962597 1.63524689586124e-08 mirMAP -0.279432421275225 0.00110962626843098 NA NA NA hsa-miR-19b-3p KCNJ5 0.601279551368824 0.00016685097085251 1.40144080962597 1.63524689586124e-08 mirMAP -0.190386600617781 0.0131457801945709 NA NA NA hsa-miR-146b-5p KCNK2 0.419719546795449 0.0457375823220155 -1.05245883813564 0.004513177443484 miRanda -0.236040824389411 0.00618890867517555 NA NA NA hsa-miR-221-3p KCNK2 1.12244756358612 3.48370308238012e-13 -1.05245883813564 0.004513177443484 MirTarget -0.341457459965925 0.00279992007191986 NA NA NA hsa-miR-222-3p KCNK2 1.08574156066353 1.76407192348131e-11 -1.05245883813564 0.004513177443484 MirTarget -0.219310005757635 0.0460718941784449 NA NA NA hsa-miR-15a-5p KCNK3 0.349521211668244 0.000770735998804736 -2.08254620993755 4.47773769423118e-10 mirMAP -0.490946748754727 0.00223639735041176 NA NA NA hsa-miR-34a-5p KCNK3 1.03694231790865 5.74864019540594e-14 -2.08254620993755 4.47773769423118e-10 MirTarget -0.594652437042294 2.89765101775678e-07 NA NA NA hsa-miR-17-3p KCNMA1 0.410352776142368 0.00422200500748636 -1.61689069754613 3.52157504789145e-11 miRNATAP -0.317784563267316 0.000175744276156095 NA NA NA hsa-miR-181b-5p KCNMA1 0.488256489401108 0.00105321129419701 -1.61689069754613 3.52157504789145e-11 miRNATAP -0.288278276628586 0.000399476528351128 NA NA NA hsa-miR-20a-5p KCNMA1 0.854326758727003 5.04256669663285e-07 -1.61689069754613 3.52157504789145e-11 miRNATAP -0.403459579869688 7.42258018508444e-09 NA NA NA hsa-miR-192-5p KCNMB4 -0.50188499512787 0.00344713341196035 -0.565600197461349 0.00811780048545861 miRNAWalker2_validate -0.49913293058438 1.28736199385812e-17 NA NA NA hsa-miR-215-5p KCNMB4 -0.981544773246509 3.14452272477156e-05 -0.565600197461349 0.00811780048545861 miRNAWalker2_validate -0.117500674707409 0.00739892062899261 NA NA NA hsa-miR-455-5p KCNN3 -0.270546034117157 0.0581320703577731 1.31693440233029 1.88465592169231e-10 miRanda -0.211183703447411 0.00350466858956857 NA NA NA hsa-miR-192-5p KCNS3 -0.50188499512787 0.00344713341196035 -0.63866106057285 0.0182642298998396 miRNAWalker2_validate -0.329965109991236 1.54493827464146e-05 NA NA NA hsa-miR-15a-5p KCTD1 0.349521211668244 0.000770735998804736 0.61675362734078 1.27856027286252e-05 miRNATAP -0.132037236196458 0.0497781330875265 NA NA NA hsa-miR-455-5p KCTD10 -0.270546034117157 0.0581320703577731 0.322240866701679 3.57260096087696e-06 miRanda -0.108691215022144 4.57774412106467e-06 NA NA NA hsa-miR-192-5p KCTD12 -0.50188499512787 0.00344713341196035 -0.70118053103332 3.33540431875856e-05 miRNAWalker2_validate -0.405918816304511 2.02681062305184e-18 NA NA NA hsa-miR-19b-3p KCTD12 0.601279551368824 0.00016685097085251 -0.70118053103332 3.33540431875856e-05 mirMAP -0.259720634692552 3.89474789812926e-07 NA NA NA hsa-miR-192-5p KCTD15 -0.50188499512787 0.00344713341196035 -0.0430097733946178 0.834208685250747 miRNAWalker2_validate -0.407163964667571 6.56885888036832e-13 NA NA NA hsa-miR-215-5p KCTD15 -0.981544773246509 3.14452272477156e-05 -0.0430097733946178 0.834208685250747 miRNAWalker2_validate -0.101478120265039 0.015803836769402 NA NA NA hsa-miR-455-3p KCTD15 -1.3998033821095 5.72010709806871e-17 -0.0430097733946178 0.834208685250747 mirMAP -0.21265901047756 0.000208471116017587 NA NA NA hsa-miR-455-5p KCTD15 -0.270546034117157 0.0581320703577731 -0.0430097733946178 0.834208685250747 miRanda;miRNATAP -0.203936392486125 0.00366844386045067 NA NA NA hsa-miR-148a-3p KCTD2 -0.748702855596996 3.93313343865641e-07 0.444262357803045 9.18948608129488e-08 mirMAP -0.140951745613528 2.08242607078795e-07 NA NA NA hsa-miR-30b-5p KCTD20 -0.54056186708617 2.44688760798341e-05 -0.125711334634429 0.379161923817538 MirTarget -0.140720516993637 0.00926532627015014 NA NA NA hsa-miR-192-5p KCTD7 -0.50188499512787 0.00344713341196035 1.34250062788809 1.70420639599115e-29 mirMAP -0.139496609377273 0.000109662023674193 NA NA NA hsa-miR-30b-5p KCTD7 -0.54056186708617 2.44688760798341e-05 1.34250062788809 1.70420639599115e-29 mirMAP -0.140353445489832 0.00373827339298883 NA NA NA hsa-miR-30e-5p KCTD7 -0.627815042856657 3.02205690184908e-10 1.34250062788809 1.70420639599115e-29 mirMAP -0.176497768173829 0.00425087434291983 NA NA NA hsa-miR-29c-3p KDELC1 -1.4367517608807 1.61767774905781e-21 0.312265832132728 0.0279604576715795 miRNATAP -0.299343744164755 2.26906379242634e-12 NA NA NA hsa-miR-192-3p KDELC2 -0.6401165114007 0.000266272092403814 -0.649277022737812 4.22286599020782e-06 mirMAP -0.13846154507391 0.000420427833731387 NA NA NA hsa-miR-192-5p KDELC2 -0.50188499512787 0.00344713341196035 -0.649277022737812 4.22286599020782e-06 miRNAWalker2_validate -0.154128350722706 0.000127719138751387 NA NA NA hsa-miR-20a-5p KDELC2 0.854326758727003 5.04256669663285e-07 -0.649277022737812 4.22286599020782e-06 mirMAP -0.18696431585746 3.01622700853284e-06 NA NA NA hsa-miR-455-5p KDELC2 -0.270546034117157 0.0581320703577731 -0.649277022737812 4.22286599020782e-06 miRanda -0.20314678761623 2.82075048923024e-05 NA NA NA hsa-miR-181b-5p KDELR2 0.488256489401108 0.00105321129419701 -0.114979701289307 0.117011025384267 mirMAP -0.134595174582584 9.27539453471284e-09 NA NA NA hsa-miR-29c-3p KDM5B -1.4367517608807 1.61767774905781e-21 0.579748004019151 7.00896705994528e-05 miRNAWalker2_validate;MirTarget -0.120628991462934 0.00759832294929716 NA NA NA hsa-miR-29c-3p KDM5C -1.4367517608807 1.61767774905781e-21 0.288107933589749 0.000275647234944698 miRNATAP -0.126657081037853 1.49943346131455e-07 NA NA NA hsa-miR-15a-5p KDR 0.349521211668244 0.000770735998804736 -0.806222400057247 9.66990863598643e-06 miRNATAP -0.372756033627348 1.49275800717172e-05 NA NA NA hsa-miR-455-5p KDR -0.270546034117157 0.0581320703577731 -0.806222400057247 9.66990863598643e-06 PITA;miRanda;miRNATAP -0.147638140508119 0.0192420100228486 NA NA NA hsa-miR-15a-5p KDSR 0.349521211668244 0.000770735998804736 -0.9262604928472 1.15465124411196e-28 miRNATAP -0.12934197881305 0.00203493572262837 NA NA NA hsa-miR-20a-5p KDSR 0.854326758727003 5.04256669663285e-07 -0.9262604928472 1.15465124411196e-28 mirMAP -0.170614440987005 4.4195348151241e-12 NA NA NA hsa-miR-17-3p KIAA0232 0.410352776142368 0.00422200500748636 0.388093668388449 4.46357119146804e-06 MirTarget -0.102210550766795 0.000395783262012819 NA NA NA hsa-miR-21-5p KIAA0355 1.51084295924322 1.54551622173259e-34 0.0309935715483438 0.728406529714885 MirTarget -0.149906051615669 3.03724363617167e-06 NA NA NA hsa-miR-221-3p KIAA0430 1.12244756358612 3.48370308238012e-13 -0.22181354906702 0.00175734986558445 MirTarget;miRNATAP -0.114871770181451 8.77375299524028e-08 NA NA NA hsa-miR-148a-3p KIAA0513 -0.748702855596996 3.93313343865641e-07 0.677391070221105 4.5635483547066e-07 mirMAP -0.253703395270591 6.57401063298589e-09 NA NA NA hsa-miR-19b-3p KIAA0513 0.601279551368824 0.00016685097085251 0.677391070221105 4.5635483547066e-07 mirMAP -0.131644875245607 0.00140775807203724 NA NA NA hsa-miR-20a-5p KIAA0513 0.854326758727003 5.04256669663285e-07 0.677391070221105 4.5635483547066e-07 MirTarget;miRNATAP -0.163197776938442 2.00326487179233e-05 NA NA NA hsa-miR-30c-5p KIAA0513 -0.432111642767632 0.000159764714931007 0.677391070221105 4.5635483547066e-07 mirMAP -0.191988139654946 0.000894405135517291 NA NA NA hsa-miR-455-3p KIAA0513 -1.3998033821095 5.72010709806871e-17 0.677391070221105 4.5635483547066e-07 mirMAP -0.281959752996363 2.62010100568908e-14 NA NA NA hsa-miR-505-5p KIAA0513 -0.768282569967001 1.14662846595407e-05 0.677391070221105 4.5635483547066e-07 mirMAP -0.106489318080932 0.00452264843543058 NA NA NA hsa-miR-192-3p KIAA0556 -0.6401165114007 0.000266272092403814 0.928114699642088 1.01412287428593e-18 mirMAP -0.14043132701345 2.86493967724253e-06 NA NA NA hsa-miR-20a-5p KIAA0922 0.854326758727003 5.04256669663285e-07 -0.958565281032929 8.72333409466684e-14 MirTarget -0.193109143479041 1.89920385030834e-07 NA NA NA hsa-miR-29c-3p KIAA1024 -1.4367517608807 1.61767774905781e-21 0.736573717526094 0.00555757243672091 MirTarget;miRNATAP -0.220996214908894 0.00705258502440715 NA NA NA hsa-miR-455-5p KIAA1211 -0.270546034117157 0.0581320703577731 -0.948503611762916 0.00378142372567747 miRanda -0.294719585857575 0.00886759081834722 NA NA NA hsa-miR-34a-5p KIAA1217 1.03694231790865 5.74864019540594e-14 -0.746538996164579 1.39364818108458e-11 MirTarget;miRNATAP -0.168432028896504 1.25473217389439e-05 NA NA NA hsa-miR-148a-3p KIAA1324L -0.748702855596996 3.93313343865641e-07 -0.50219104365772 0.0775324724611569 MirTarget;miRNATAP -0.427112379558327 3.63673905587508e-06 NA NA NA hsa-miR-455-5p KIAA1324L -0.270546034117157 0.0581320703577731 -0.50219104365772 0.0775324724611569 miRanda -0.405902940586016 2.78958535204572e-05 NA NA NA hsa-miR-29c-3p KIAA1522 -1.4367517608807 1.61767774905781e-21 1.42624754416946 2.16018298815645e-24 mirMAP -0.377750250850026 7.45984144135561e-18 NA NA NA hsa-miR-30c-5p KIAA1522 -0.432111642767632 0.000159764714931007 1.42624754416946 2.16018298815645e-24 mirMAP;miRNATAP -0.131250064445037 0.0381619696622513 NA NA NA hsa-miR-148a-3p KIAA1549 -0.748702855596996 3.93313343865641e-07 0.660027387081498 0.0355851637057295 miRNAWalker2_validate -0.332119877358287 0.00120295124376642 NA NA NA hsa-miR-192-3p KIAA1549 -0.6401165114007 0.000266272092403814 0.660027387081498 0.0355851637057295 mirMAP -0.603895117869421 9.82582043260026e-13 NA NA NA hsa-miR-30c-5p KIAA1549 -0.432111642767632 0.000159764714931007 0.660027387081498 0.0355851637057295 miRNATAP -0.492186785444161 0.000226894990174669 NA NA NA hsa-miR-27b-3p KIAA1614 -0.823491817819754 9.20935302746823e-14 1.19012149096204 4.91603849396984e-08 mirMAP -0.41211964337427 1.39968825837083e-05 NA NA NA hsa-miR-29c-3p KIAA1614 -1.4367517608807 1.61767774905781e-21 1.19012149096204 4.91603849396984e-08 mirMAP -0.298952626832753 1.02069473048697e-05 NA NA NA hsa-miR-455-3p KIAA1614 -1.3998033821095 5.72010709806871e-17 1.19012149096204 4.91603849396984e-08 mirMAP -0.203009267634137 0.00107805799931549 NA NA NA hsa-miR-148a-3p KIAA1644 -0.748702855596996 3.93313343865641e-07 -1.81284684066633 3.233194276281e-09 mirMAP -0.610055069449491 1.16426577116176e-09 NA NA NA hsa-miR-15a-5p KIAA1644 0.349521211668244 0.000770735998804736 -1.81284684066633 3.233194276281e-09 mirMAP -0.394142085661288 0.00739170055493142 NA NA NA hsa-miR-17-3p KIAA1644 0.410352776142368 0.00422200500748636 -1.81284684066633 3.233194276281e-09 mirMAP -0.382417224973383 0.000300878143903712 NA NA NA hsa-miR-194-5p KIAA1644 -0.292530160992458 0.0996141384876663 -1.81284684066633 3.233194276281e-09 mirMAP -0.636269494228493 2.10292372655431e-14 NA NA NA hsa-miR-34a-5p KIAA1644 1.03694231790865 5.74864019540594e-14 -1.81284684066633 3.233194276281e-09 MirTarget -0.283178472473828 0.00830852853407459 NA NA NA hsa-miR-146b-5p KIAA1671 0.419719546795449 0.0457375823220155 -0.839733934948399 1.10952867050449e-11 mirMAP -0.100307121393901 0.000614512572290355 NA NA NA hsa-miR-21-5p KIAA1671 1.51084295924322 1.54551622173259e-34 -0.839733934948399 1.10952867050449e-11 mirMAP -0.164845382686981 0.000345737631950021 NA NA NA hsa-miR-503-5p KIAA1671 0.191949282338049 0.268420664548092 -0.839733934948399 1.10952867050449e-11 miRNAWalker2_validate -0.141996594532264 6.31785073033928e-05 NA NA NA hsa-miR-192-5p KIAA1841 -0.50188499512787 0.00344713341196035 1.62652740403476 2.37568671779387e-32 miRNAWalker2_validate -0.179183516886591 1.86277536369118e-05 NA NA NA hsa-miR-30b-5p KIAA1958 -0.54056186708617 2.44688760798341e-05 -0.516263276208278 0.00431830868274674 mirMAP -0.258723773654267 0.000158003724456567 NA NA NA hsa-miR-30b-5p KIF11 -0.54056186708617 2.44688760798341e-05 2.12256950255577 1.1749435800197e-28 MirTarget -0.157344644549316 0.0432793975341663 NA NA NA hsa-miR-30e-5p KIF11 -0.627815042856657 3.02205690184908e-10 2.12256950255577 1.1749435800197e-28 MirTarget -0.320932566533637 0.00117382777442761 NA NA NA hsa-miR-15a-5p KIF13B 0.349521211668244 0.000770735998804736 -0.482636544771593 7.59212283236002e-06 mirMAP -0.222259148552227 1.23171157351755e-05 NA NA NA hsa-miR-148a-3p KIF14 -0.748702855596996 3.93313343865641e-07 2.98333269436721 7.27784939820496e-37 MirTarget -0.352344124898679 2.55851993740245e-05 NA NA NA hsa-miR-215-5p KIF15 -0.981544773246509 3.14452272477156e-05 3.46496144896513 1.75184188551877e-30 miRNAWalker2_validate -0.214759003835981 0.00125146429596479 NA NA NA hsa-miR-192-5p KIF18A -0.50188499512787 0.00344713341196035 3.68362475076135 8.5674684516454e-42 miRNAWalker2_validate -0.219605792296084 0.0103153094385285 NA NA NA hsa-miR-215-5p KIF18A -0.981544773246509 3.14452272477156e-05 3.68362475076135 8.5674684516454e-42 miRNAWalker2_validate -0.159929841938743 0.00970724439995468 NA NA NA hsa-miR-182-5p KIF19 1.96601340710222 4.39326175603633e-09 -3.2481765769351 8.46270539025339e-36 miRNATAP -0.169727546017997 2.49005617154579e-05 NA NA NA hsa-miR-34a-5p KIF1A 1.03694231790865 5.74864019540594e-14 -0.61833871884297 0.18596206750766 mirMAP -0.529719153847603 0.000947096234557464 NA NA NA hsa-miR-30b-5p KIF1B -0.54056186708617 2.44688760798341e-05 -0.0268150253504089 0.784984841184853 mirMAP -0.13479491876932 0.000263955016001824 NA NA NA hsa-miR-455-5p KIF1B -0.270546034117157 0.0581320703577731 -0.0268150253504089 0.784984841184853 PITA;miRanda;miRNATAP -0.138498898497324 3.18948901774901e-05 NA NA NA hsa-miR-192-5p KIF20A -0.50188499512787 0.00344713341196035 4.26453769688785 7.51182825648091e-50 miRNAWalker2_validate -0.238877638274429 0.00963840729740923 NA NA NA hsa-miR-215-5p KIF20A -0.981544773246509 3.14452272477156e-05 4.26453769688785 7.51182825648091e-50 miRNAWalker2_validate -0.196400623125643 0.00318131590708163 NA NA NA hsa-miR-148a-3p KIF21B -0.748702855596996 3.93313343865641e-07 1.1784578803772 5.28752515379585e-07 mirMAP -0.282228303711302 0.000272557559842213 NA NA NA hsa-miR-192-5p KIF21B -0.50188499512787 0.00344713341196035 1.1784578803772 5.28752515379585e-07 mirMAP -0.163458605405113 0.0155582786328581 NA NA NA hsa-miR-27b-3p KIF21B -0.823491817819754 9.20935302746823e-14 1.1784578803772 5.28752515379585e-07 miRNATAP -0.674623589337565 1.75552772532421e-11 NA NA NA hsa-miR-30c-5p KIF21B -0.432111642767632 0.000159764714931007 1.1784578803772 5.28752515379585e-07 mirMAP -0.277399607869543 0.00625088964404866 NA NA NA hsa-miR-455-3p KIF21B -1.3998033821095 5.72010709806871e-17 1.1784578803772 5.28752515379585e-07 mirMAP -0.347783635858719 1.37810525119751e-07 NA NA NA hsa-miR-455-5p KIF21B -0.270546034117157 0.0581320703577731 1.1784578803772 5.28752515379585e-07 miRanda -0.274475488191245 0.000740050656647041 NA NA NA hsa-miR-146a-5p KIF22 -0.742958238440575 0.000765983177482633 0.589082652701814 4.78709627056598e-07 miRNAWalker2_validate -0.116501490796731 6.2347271119732e-06 NA NA NA hsa-miR-192-5p KIF23 -0.50188499512787 0.00344713341196035 3.38260867585201 1.68312480021973e-36 miRNAWalker2_validate -0.294660430754535 0.000382369285256339 NA NA NA hsa-miR-215-5p KIF23 -0.981544773246509 3.14452272477156e-05 3.38260867585201 1.68312480021973e-36 miRNAWalker2_validate -0.159600593147677 0.00794540428697346 NA NA NA hsa-miR-192-5p KIF24 -0.50188499512787 0.00344713341196035 1.6808929894047 1.02551673781485e-23 miRNAWalker2_validate -0.172032148536495 0.000597193013295968 NA NA NA hsa-miR-215-5p KIF24 -0.981544773246509 3.14452272477156e-05 1.6808929894047 1.02551673781485e-23 miRNAWalker2_validate -0.10068655535872 0.00552821779100029 NA NA NA hsa-miR-148a-3p KIF26B -0.748702855596996 3.93313343865641e-07 0.149322876930793 0.640083141858917 mirMAP -0.839423184214391 6.45316185740642e-17 NA NA NA hsa-miR-192-3p KIF26B -0.6401165114007 0.000266272092403814 0.149322876930793 0.640083141858917 mirMAP -0.710836116341779 5.71173960397877e-17 NA NA NA hsa-miR-455-3p KIF26B -1.3998033821095 5.72010709806871e-17 0.149322876930793 0.640083141858917 mirMAP -0.370792875915789 3.08569366346775e-05 NA NA NA hsa-miR-27b-3p KIF3A -0.823491817819754 9.20935302746823e-14 0.691331553038427 1.99469350865959e-10 miRNATAP -0.18933309631604 6.78320317519226e-05 NA NA NA hsa-miR-455-5p KIF3A -0.270546034117157 0.0581320703577731 0.691331553038427 1.99469350865959e-10 miRanda -0.183601765928307 1.03936583831029e-06 NA NA NA hsa-miR-15a-5p KIF3B 0.349521211668244 0.000770735998804736 0.102047831870286 0.163597989974475 MirTarget -0.272741609883262 1.62291509641711e-16 NA NA NA hsa-miR-192-5p KIF5C -0.50188499512787 0.00344713341196035 0.269855133812925 0.290746010454243 miRNAWalker2_validate -0.302444148722263 2.60065043542956e-05 NA NA NA hsa-miR-215-5p KIFC1 -0.981544773246509 3.14452272477156e-05 3.81845068159089 7.73714657078986e-49 miRNAWalker2_validate -0.1659695357186 0.0057845255435337 NA NA NA hsa-miR-29c-3p KIFC2 -1.4367517608807 1.61767774905781e-21 1.89667653860792 5.58244612225434e-28 miRNATAP -0.298981642818688 1.08261439622495e-07 NA NA NA hsa-miR-192-5p KIRREL -0.50188499512787 0.00344713341196035 -0.920556464539881 0.00842298893942037 mirMAP -0.585518652995115 2.03826200929185e-09 NA NA NA hsa-miR-146b-5p KIT 0.419719546795449 0.0457375823220155 -0.36947956147857 0.0945270050690569 miRNAWalker2_validate -0.120535544137378 0.0187610976519063 NA NA NA hsa-miR-19b-3p KIT 0.601279551368824 0.00016685097085251 -0.36947956147857 0.0945270050690569 miRNATAP -0.141362307947708 0.035544991242993 NA NA NA hsa-miR-20a-5p KIT 0.854326758727003 5.04256669663285e-07 -0.36947956147857 0.0945270050690569 miRTarBase -0.225765388624807 0.000296472897214121 NA NA NA hsa-miR-34a-5p KIT 1.03694231790865 5.74864019540594e-14 -0.36947956147857 0.0945270050690569 MirTarget -0.159543555669109 0.0358933176735168 NA NA NA hsa-miR-192-3p KITLG -0.6401165114007 0.000266272092403814 0.795506881904605 2.04054574930174e-05 mirMAP -0.295004448161722 8.59654669637728e-09 NA NA NA hsa-miR-30b-5p KITLG -0.54056186708617 2.44688760798341e-05 0.795506881904605 2.04054574930174e-05 mirMAP -0.16449999136192 0.0213982425666408 NA NA NA hsa-miR-148a-3p KLC2 -0.748702855596996 3.93313343865641e-07 1.16492926016379 3.19134150923749e-23 miRNATAP -0.397394995398343 2.12082762386537e-25 NA NA NA hsa-miR-30c-5p KLC2 -0.432111642767632 0.000159764714931007 1.16492926016379 3.19134150923749e-23 miRNAWalker2_validate -0.137406487379411 0.00927474275757388 NA NA NA hsa-miR-20a-5p KLF11 0.854326758727003 5.04256669663285e-07 -1.24274309965741 2.39323027053722e-26 MirTarget;miRNATAP -0.111614999790648 0.00153641286067475 NA NA NA hsa-miR-132-3p KLF12 0.323796239695997 0.00272093067935091 -0.863221902725629 5.4142350807271e-09 mirMAP -0.478430597540018 6.37564951362206e-13 NA NA NA hsa-miR-181a-5p KLF12 0.250113435902954 0.0551933249319293 -0.863221902725629 5.4142350807271e-09 mirMAP -0.325941757768677 4.62599406759919e-09 NA NA NA hsa-miR-181b-5p KLF12 0.488256489401108 0.00105321129419701 -0.863221902725629 5.4142350807271e-09 mirMAP -0.391881112421738 1.42240874764241e-16 NA NA NA hsa-miR-21-5p KLF12 1.51084295924322 1.54551622173259e-34 -0.863221902725629 5.4142350807271e-09 mirMAP -0.545651132892819 4.906175473079e-26 NA NA NA hsa-miR-146a-5p KLF13 -0.742958238440575 0.000765983177482633 1.11571195583237 1.69897534012305e-15 mirMAP -0.161042072931607 3.17910942681477e-07 NA NA NA hsa-miR-29c-3p KLF13 -1.4367517608807 1.61767774905781e-21 1.11571195583237 1.69897534012305e-15 miRNATAP -0.165173060975356 0.00020465637556122 NA NA NA hsa-miR-455-3p KLF13 -1.3998033821095 5.72010709806871e-17 1.11571195583237 1.69897534012305e-15 PITA;miRNATAP -0.126414143288103 0.00187601444413353 NA NA NA hsa-miR-181a-5p KLF15 0.250113435902954 0.0551933249319293 -0.258492610641029 0.233857215291637 MirTarget;miRNATAP -0.547176528432154 5.91374434609888e-12 NA NA NA hsa-miR-181b-5p KLF15 0.488256489401108 0.00105321129419701 -0.258492610641029 0.233857215291637 MirTarget;miRNATAP -0.592776786977719 2.90270791267021e-18 NA NA NA hsa-miR-182-5p KLF15 1.96601340710222 4.39326175603633e-09 -0.258492610641029 0.233857215291637 MirTarget;miRNATAP -0.180816069350451 2.74957215017235e-09 NA NA NA hsa-miR-409-3p KLF15 -0.499649792570937 0.0526751181520117 -0.258492610641029 0.233857215291637 MirTarget;PITA -0.137072856488518 0.00079042956675302 NA NA NA hsa-miR-21-5p KLF3 1.51084295924322 1.54551622173259e-34 -0.612085068754795 1.13963384347611e-13 miRNATAP -0.230378723364208 1.47789299053091e-14 NA NA NA hsa-miR-148a-3p KLF4 -0.748702855596996 3.93313343865641e-07 -1.65022485340468 8.09789885316327e-13 MirTarget;miRNATAP -0.22838478886868 0.00318884817829108 NA NA NA hsa-miR-181a-5p KLF6 0.250113435902954 0.0551933249319293 -1.43852959018658 4.46638206050043e-20 miRNAWalker2_validate;miRTarBase;miRNATAP -0.231855010292488 0.000160207637173006 22581522 Site-directed mutagenesis and luciferase reporter assay demonstrated that miR-181a repressed KLF6 expression by targeting its 3'-UTR; Western blot analysis further showed that KLF6 protein was significantly decreased or increased when miR-181a mimic or inhibitor was transfected into SGC-7901 cells respectively; In summary these data suggest that KLF6 gene is a direct target of miR-181a and miR-181a functions as an oncomir in gastric cancer by repressing the expression of tumor suppressor KLF6 gastric cancer hsa-miR-181b-5p KLF6 0.488256489401108 0.00105321129419701 -1.43852959018658 4.46638206050043e-20 miRNATAP -0.235936980083028 9.42607903875365e-06 NA NA NA hsa-miR-19b-3p KLF6 0.601279551368824 0.00016685097085251 -1.43852959018658 4.46638206050043e-20 miRNATAP -0.199238380615214 6.02388556198622e-05 NA NA NA hsa-miR-21-5p KLF6 1.51084295924322 1.54551622173259e-34 -1.43852959018658 4.46638206050043e-20 miRNATAP -0.265009732469504 8.49803425647928e-06 NA NA NA hsa-miR-455-5p KLF6 -0.270546034117157 0.0581320703577731 -1.43852959018658 4.46638206050043e-20 miRanda -0.164233636389679 0.00349359984300218 NA NA NA hsa-miR-194-5p KLF7 -0.292530160992458 0.0996141384876663 -1.04701042856457 5.35024579653903e-05 miRNATAP -0.399177420779695 1.68287169595463e-08 NA NA NA hsa-miR-19b-3p KLF7 0.601279551368824 0.00016685097085251 -1.04701042856457 5.35024579653903e-05 MirTarget;miRNATAP -0.177967524667994 0.0251777573471557 NA NA NA hsa-miR-224-3p KLF7 1.40770116795301 1.31426607144612e-08 -1.04701042856457 5.35024579653903e-05 mirMAP -0.13642748970918 0.00768198367000682 NA NA NA hsa-miR-34a-5p KLF7 1.03694231790865 5.74864019540594e-14 -1.04701042856457 5.35024579653903e-05 miRNATAP -0.262969568663767 0.00337070959839393 NA NA NA hsa-miR-455-5p KLF8 -0.270546034117157 0.0581320703577731 -0.847230251421478 2.16714564459626e-05 miRanda -0.225925809700883 0.00102071539901077 NA NA NA hsa-miR-181b-5p KLF9 0.488256489401108 0.00105321129419701 -1.35905833834713 1.22932810880238e-12 mirMAP -0.612400156392753 7.19443960440113e-24 NA NA NA hsa-miR-20a-5p KLF9 0.854326758727003 5.04256669663285e-07 -1.35905833834713 1.22932810880238e-12 MirTarget;miRNATAP -0.30995057380615 1.69132518578895e-08 NA NA NA hsa-miR-20b-5p KLF9 0.457668023910379 0.0285865211936156 -1.35905833834713 1.22932810880238e-12 MirTarget;miRNATAP -0.158189613574083 0.000536864994037854 NA NA NA hsa-miR-21-5p KLF9 1.51084295924322 1.54551622173259e-34 -1.35905833834713 1.22932810880238e-12 miRNAWalker2_validate -0.607422599570453 1.16785059060082e-18 NA NA NA hsa-miR-221-3p KLF9 1.12244756358612 3.48370308238012e-13 -1.35905833834713 1.22932810880238e-12 miRNAWalker2_validate -0.558617680931615 2.50451535003869e-22 NA NA NA hsa-miR-409-3p KLF9 -0.499649792570937 0.0526751181520117 -1.35905833834713 1.22932810880238e-12 mirMAP -0.144256589014342 9.49494396827201e-05 NA NA NA hsa-miR-20a-5p KLHDC10 0.854326758727003 5.04256669663285e-07 -0.301845977708177 0.070704300321483 mirMAP -0.234470415341675 5.45674023510128e-07 NA NA NA hsa-miR-20b-5p KLHDC10 0.457668023910379 0.0285865211936156 -0.301845977708177 0.070704300321483 mirMAP -0.142492267484524 0.000234525635205629 NA NA NA hsa-miR-30b-5p KLHDC10 -0.54056186708617 2.44688760798341e-05 -0.301845977708177 0.070704300321483 mirMAP -0.215809649263491 0.000628786150861095 NA NA NA hsa-miR-29c-3p KLHDC3 -1.4367517608807 1.61767774905781e-21 0.390165827608807 0.000103456605658408 MirTarget;miRNATAP -0.150859011263005 9.37103614179135e-07 NA NA NA hsa-miR-181a-5p KLHL15 0.250113435902954 0.0551933249319293 -1.43616317329618 4.62856180062188e-29 miRNAWalker2_validate;mirMAP;miRNATAP -0.215710757778653 2.6610831100319e-05 NA NA NA hsa-miR-181b-5p KLHL15 0.488256489401108 0.00105321129419701 -1.43616317329618 4.62856180062188e-29 mirMAP;miRNATAP -0.237211100714084 9.0404508427053e-08 NA NA NA hsa-miR-19b-3p KLHL15 0.601279551368824 0.00016685097085251 -1.43616317329618 4.62856180062188e-29 miRNATAP -0.111903604232952 0.00746212577072972 NA NA NA hsa-miR-20a-5p KLHL15 0.854326758727003 5.04256669663285e-07 -1.43616317329618 4.62856180062188e-29 miRNAWalker2_validate;miRNATAP -0.178014150512801 4.18811751623471e-06 NA NA NA hsa-miR-21-5p KLHL15 1.51084295924322 1.54551622173259e-34 -1.43616317329618 4.62856180062188e-29 miRNAWalker2_validate;miRNATAP -0.656684809309307 3.29358691062809e-49 NA NA NA hsa-miR-148a-3p KLHL17 -0.748702855596996 3.93313343865641e-07 1.05691261770448 1.98597989430383e-20 MirTarget -0.16415613709474 2.35704886125403e-05 NA NA NA hsa-miR-148a-3p KLHL18 -0.748702855596996 3.93313343865641e-07 0.143407270163824 0.0265548542763812 mirMAP;miRNATAP -0.100825219689263 1.21939637109394e-06 NA NA NA hsa-miR-15a-5p KLHL2 0.349521211668244 0.000770735998804736 -1.16669881935719 4.68056312110186e-18 miRNATAP -0.266500334347395 5.09800294771088e-05 NA NA NA hsa-miR-181a-5p KLHL2 0.250113435902954 0.0551933249319293 -1.16669881935719 4.68056312110186e-18 miRNATAP -0.362370504973909 1.7573305337809e-12 NA NA NA hsa-miR-181b-5p KLHL2 0.488256489401108 0.00105321129419701 -1.16669881935719 4.68056312110186e-18 miRNATAP -0.401494260768221 4.98148474153148e-20 NA NA NA hsa-miR-182-5p KLHL2 1.96601340710222 4.39326175603633e-09 -1.16669881935719 4.68056312110186e-18 miRNATAP -0.120196624630421 9.64456987227061e-10 NA NA NA hsa-miR-20a-5p KLHL2 0.854326758727003 5.04256669663285e-07 -1.16669881935719 4.68056312110186e-18 miRNATAP -0.265328254818428 8.61387267689936e-12 NA NA NA hsa-miR-20b-5p KLHL2 0.457668023910379 0.0285865211936156 -1.16669881935719 4.68056312110186e-18 miRNATAP -0.115168774297734 0.00040989570632931 NA NA NA hsa-miR-455-5p KLHL2 -0.270546034117157 0.0581320703577731 -1.16669881935719 4.68056312110186e-18 miRanda -0.107463223429108 0.0256000635069318 NA NA NA hsa-miR-19b-3p KLHL20 0.601279551368824 0.00016685097085251 -0.255034662137329 0.0290056608745733 MirTarget;miRNATAP -0.133403699393376 0.000157957468281289 NA NA NA hsa-miR-20a-5p KLHL20 0.854326758727003 5.04256669663285e-07 -0.255034662137329 0.0290056608745733 MirTarget;miRNATAP -0.153322225407423 2.91009251249848e-06 NA NA NA hsa-miR-30b-5p KLHL20 -0.54056186708617 2.44688760798341e-05 -0.255034662137329 0.0290056608745733 MirTarget -0.106231263379 0.016443324218321 NA NA NA hsa-miR-146b-5p KLHL24 0.419719546795449 0.0457375823220155 -0.401981621711891 5.62016159465388e-05 miRanda -0.122965041584629 8.50391577885702e-08 NA NA NA hsa-miR-21-5p KLHL24 1.51084295924322 1.54551622173259e-34 -0.401981621711891 5.62016159465388e-05 miRNAWalker2_validate -0.302519889785232 8.17078443675782e-18 NA NA NA hsa-miR-146b-5p KLHL29 0.419719546795449 0.0457375823220155 0.702399434101004 0.0109280929385441 miRanda -0.184067015532784 0.00408881975831966 NA NA NA hsa-miR-27b-3p KLHL29 -0.823491817819754 9.20935302746823e-14 0.702399434101004 0.0109280929385441 miRNATAP -0.480395842021738 5.08250476487496e-05 NA NA NA hsa-miR-192-3p KLHL3 -0.6401165114007 0.000266272092403814 -0.82550240612119 0.00204726487055326 mirMAP -0.191525033982503 0.00995580584202869 NA NA NA hsa-miR-21-5p KLHL4 1.51084295924322 1.54551622173259e-34 -1.08539693977576 1.31560067160153e-06 mirMAP -0.175487393215786 0.0345586631691532 NA NA NA hsa-miR-148a-3p KLHL6 -0.748702855596996 3.93313343865641e-07 -0.339592374400176 0.0756406505671127 mirMAP -0.359369362340502 5.01732126782505e-09 NA NA NA hsa-miR-20a-5p KLHL8 0.854326758727003 5.04256669663285e-07 -0.860556861719106 3.7235566785704e-09 mirMAP -0.257869855292933 4.35449633462033e-10 NA NA NA hsa-miR-221-3p KLHL8 1.12244756358612 3.48370308238012e-13 -0.860556861719106 3.7235566785704e-09 miRNAWalker2_validate -0.331993361082056 7.49559007688179e-14 NA NA NA hsa-miR-34a-5p KLRK1 1.03694231790865 5.74864019540594e-14 -1.3438720667387 3.96199546501886e-08 MirTarget -0.271724198018642 0.00144321785749136 NA NA NA hsa-miR-181a-5p KPNA1 0.250113435902954 0.0551933249319293 -0.315101680458858 2.00299187243101e-06 MirTarget;miRNATAP -0.137711108681298 2.25846880787861e-08 NA NA NA hsa-miR-181b-5p KPNA1 0.488256489401108 0.00105321129419701 -0.315101680458858 2.00299187243101e-06 MirTarget;miRNATAP -0.12537756436499 4.56043164022635e-09 NA NA NA hsa-miR-19b-3p KPNA6 0.601279551368824 0.00016685097085251 -0.221388310063308 0.00128672982834015 MirTarget;miRNATAP -0.107512277510893 1.78091745897465e-07 NA NA NA hsa-miR-221-3p KPNA6 1.12244756358612 3.48370308238012e-13 -0.221388310063308 0.00128672982834015 miRNAWalker2_validate -0.119204640480054 9.51436736094924e-09 NA NA NA hsa-miR-17-3p KREMEN1 0.410352776142368 0.00422200500748636 0.207870784135165 0.217967443336046 mirMAP -0.135288946481329 0.0183169046803903 NA NA NA hsa-miR-455-3p KREMEN2 -1.3998033821095 5.72010709806871e-17 1.36177405578335 6.02066896824181e-06 miRNATAP -0.186389336150884 0.0292515454081673 NA NA NA hsa-miR-146b-5p KRT80 0.419719546795449 0.0457375823220155 -1.78330372707111 1.41618233654198e-05 miRanda -0.28920061232941 0.00261711681365954 NA NA NA hsa-miR-30c-5p KSR1 -0.432111642767632 0.000159764714931007 0.642891251299799 3.57442067630892e-06 MirTarget -0.141642578918507 0.0177701611380028 NA NA NA hsa-miR-30e-5p KSR1 -0.627815042856657 3.02205690184908e-10 0.642891251299799 3.57442067630892e-06 MirTarget -0.281376496008921 2.91224385327695e-05 NA NA NA hsa-miR-455-5p KSR1 -0.270546034117157 0.0581320703577731 0.642891251299799 3.57442067630892e-06 miRanda -0.142020753420233 0.00304759572991457 NA NA NA hsa-miR-148a-3p KSR2 -0.748702855596996 3.93313343865641e-07 0.506902986173332 0.110760452022147 mirMAP -0.476743808874194 3.69345752464517e-06 NA NA NA hsa-miR-192-5p KSR2 -0.50188499512787 0.00344713341196035 0.506902986173332 0.110760452022147 mirMAP -0.33303441995803 0.000208002549007142 NA NA NA hsa-miR-194-5p KSR2 -0.292530160992458 0.0996141384876663 0.506902986173332 0.110760452022147 mirMAP -0.33828430678493 9.97782396172317e-05 NA NA NA hsa-miR-29c-3p KSR2 -1.4367517608807 1.61767774905781e-21 0.506902986173332 0.110760452022147 mirMAP -0.290914822982681 0.00292330288589756 NA NA NA hsa-miR-30e-5p KSR2 -0.627815042856657 3.02205690184908e-10 0.506902986173332 0.110760452022147 mirMAP -0.406039884871926 0.0082508804785254 NA NA NA hsa-miR-30c-5p LACTB2 -0.432111642767632 0.000159764714931007 -0.190481353407825 0.165558442155251 miRNAWalker2_validate -0.125053525548524 0.0326204299788307 NA NA NA hsa-miR-146b-5p LAMA2 0.419719546795449 0.0457375823220155 -2.25093797189139 1.13318229560757e-08 miRanda -0.200973106106506 0.0311052794529279 NA NA NA hsa-miR-181a-5p LAMA3 0.250113435902954 0.0551933249319293 1.44669397870991 3.68334239314585e-06 miRNAWalker2_validate -0.480393838339496 4.68441145042477e-05 NA NA NA hsa-miR-29c-3p LAMC1 -1.4367517608807 1.61767774905781e-21 1.18164580989765 3.65525462453826e-17 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.247557685092554 2.2318434063202e-08 NA NA NA hsa-miR-192-3p LAMC3 -0.6401165114007 0.000266272092403814 -1.16336935602705 0.000136555756942437 mirMAP -0.2707235641559 0.00139897549549915 NA NA NA hsa-miR-192-5p LAMC3 -0.50188499512787 0.00344713341196035 -1.16336935602705 0.000136555756942437 mirMAP -0.298507199873094 0.00059027334318161 NA NA NA hsa-miR-19b-3p LAMP2 0.601279551368824 0.00016685097085251 -0.141489314494891 0.203338123114718 mirMAP -0.195954244431658 3.35620258397428e-09 NA NA NA hsa-miR-20a-5p LAMP2 0.854326758727003 5.04256669663285e-07 -0.141489314494891 0.203338123114718 mirMAP -0.226889701888816 1.09279668507289e-13 NA NA NA hsa-miR-20b-5p LAMP2 0.457668023910379 0.0285865211936156 -0.141489314494891 0.203338123114718 mirMAP -0.105101615242475 4.26016467392042e-05 NA NA NA hsa-miR-21-5p LAMP2 1.51084295924322 1.54551622173259e-34 -0.141489314494891 0.203338123114718 miRNAWalker2_validate -0.136266688445851 0.000736718604940198 NA NA NA hsa-miR-29c-3p LANCL1 -1.4367517608807 1.61767774905781e-21 0.346088652785245 0.000141876901316631 MirTarget -0.118707920428279 2.10238926397016e-05 NA NA NA hsa-miR-20a-5p LAPTM4A 0.854326758727003 5.04256669663285e-07 -0.311055806827135 9.12551693197731e-06 MirTarget;miRNATAP -0.159836195718942 8.84860927771635e-17 NA NA NA hsa-miR-27b-3p LAPTM4B -0.823491817819754 9.20935302746823e-14 1.07428089690096 5.86976228026329e-07 miRNAWalker2_validate -0.311046889368618 0.000898655529855941 NA NA NA hsa-miR-455-5p LAPTM5 -0.270546034117157 0.0581320703577731 -0.294369858612781 0.0736747501272379 miRanda -0.24686016258857 1.01520208536968e-05 NA NA NA hsa-miR-30c-5p LARP1 -0.432111642767632 0.000159764714931007 0.631280547716208 2.42762598419254e-16 miRNATAP -0.137223747597699 4.69836541733385e-05 NA NA NA hsa-miR-181a-5p LARP4 0.250113435902954 0.0551933249319293 -0.606974985036527 4.17599364737609e-12 MirTarget;miRNATAP -0.313992069562177 7.43412576581523e-23 NA NA NA hsa-miR-181b-5p LARP4 0.488256489401108 0.00105321129419701 -0.606974985036527 4.17599364737609e-12 MirTarget;miRNATAP -0.31541091413399 3.43274288049146e-31 NA NA NA hsa-miR-19b-3p LARP4 0.601279551368824 0.00016685097085251 -0.606974985036527 4.17599364737609e-12 mirMAP -0.113104152120082 2.90691042551818e-05 NA NA NA hsa-miR-29c-3p LARP4B -1.4367517608807 1.61767774905781e-21 0.424958931309075 1.60883657990558e-10 MirTarget;miRNATAP -0.1694713568053 2.28897397401291e-17 NA NA NA hsa-miR-146b-5p LARP6 0.419719546795449 0.0457375823220155 -0.92135432451261 0.00184946422428944 miRanda -0.25394153618758 0.000216457191018161 NA NA NA hsa-miR-29c-3p LASP1 -1.4367517608807 1.61767774905781e-21 0.523794786889897 6.87898834597451e-10 miRNATAP -0.19772139045597 1.70179917762428e-14 NA NA NA hsa-miR-505-5p LASP1 -0.768282569967001 1.14662846595407e-05 0.523794786889897 6.87898834597451e-10 miRNAWalker2_validate -0.135505154975582 7.6839769618006e-09 NA NA NA hsa-miR-20a-5p LAT2 0.854326758727003 5.04256669663285e-07 -0.473548619847502 0.00516998708211561 mirMAP -0.16301438064001 0.000679686226255119 NA NA NA hsa-miR-21-5p LATS1 1.51084295924322 1.54551622173259e-34 -0.730797585786345 4.24866694321044e-05 miRNAWalker2_validate -0.259052381224193 7.34088380250575e-05 25769949 miR 21 modulates resistance of HR HPV positive cervical cancer cells to radiation through targeting LATS1; By using dual luciferase assay we verified a binding site between miR-21 and 3'-UTR of large tumor suppressor kinase 1 LATS1; Through direct binding miR-21 can regulate LATS1 expression in cervical cancer cells; LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment drug resistance cervical and endocervical cancer hsa-miR-455-5p LAYN -0.270546034117157 0.0581320703577731 0.598417721423175 0.000265757395901991 miRanda;miRNATAP -0.261744542596661 2.98379126429422e-06 NA NA NA hsa-miR-146b-5p LCA5 0.419719546795449 0.0457375823220155 -1.01345286955957 2.78628329318733e-08 miRanda -0.107286581455491 0.0126459406811356 NA NA NA hsa-miR-455-5p LCA5 -0.270546034117157 0.0581320703577731 -1.01345286955957 2.78628329318733e-08 miRanda -0.155396294694431 0.0144885953263644 NA NA NA hsa-miR-181a-5p LCLAT1 0.250113435902954 0.0551933249319293 0.0671043462289371 0.494598904823525 miRNAWalker2_validate;MirTarget;miRNATAP -0.112980168789077 0.00205732415024079 NA NA NA hsa-miR-146b-5p LCOR 0.419719546795449 0.0457375823220155 -0.828225234134718 0.000381975258357077 miRNATAP -0.110661757976898 0.0422285597843812 NA NA NA hsa-miR-15a-5p LCOR 0.349521211668244 0.000770735998804736 -0.828225234134718 0.000381975258357077 miRNATAP -0.23336899399407 0.0350062661582779 NA NA NA hsa-miR-21-5p LCOR 1.51084295924322 1.54551622173259e-34 -0.828225234134718 0.000381975258357077 mirMAP -0.300233861296471 0.000433982911945699 NA NA NA hsa-miR-21-5p LCORL 1.51084295924322 1.54551622173259e-34 -0.465224089674271 0.000125378997414632 miRNAWalker2_validate;miRNATAP -0.169008923460901 0.000136559612734448 NA NA NA hsa-miR-455-5p LCP1 -0.270546034117157 0.0581320703577731 -0.690723067632548 0.000125187156132808 miRanda -0.300918871038932 9.7933420646332e-07 NA NA NA hsa-miR-146b-5p LDB3 0.419719546795449 0.0457375823220155 0.461919625079895 0.0250406895130154 miRanda -0.104082015732211 0.0298686574118509 NA NA NA hsa-miR-34a-5p LDHA 1.03694231790865 5.74864019540594e-14 -0.775434438225197 4.63774981304723e-13 miRNAWalker2_validate;MirTarget;miRNATAP -0.102932776252485 0.00649173851541761 26902416;25333573;27186405 The miR 34a LDHA axis regulates glucose metabolism and tumor growth in breast cancer; We also performed luciferase reporter assays and found that LDHA was a direct target of miR-34a; Repression of LDHA by miR-34a suppressed glycolysis and cell proliferation in breast cancer cells in vitro; Our findings provide clues regarding the role of miR-34a as a tumor suppressor in breast cancer through the inhibition of LDHA both in vitro and in vivo; Targeting LDHA through miR-34a could be a potential therapeutic strategy in breast cancer;Inhibition of lactate dehydrogenase A by microRNA 34a resensitizes colon cancer cells to 5 fluorouracil; Furthermore LDHA was shown to be a direct target of miR-34a; Overexpression of miR-34a reduced the expression of LDHA probably through binding to the 3' untranslated region leading to the re-sensitization of 5-FU-resistant cancer cells to 5-FU; In conclusion the current study showed that miR-34a is involved in sensitivity to 5-FU in part through its effects on LDHA expression;HPV E6/p53 mediated down regulation of miR 34a inhibits Warburg effect through targeting LDHA in cervical cancer; Subsequently lactate dehydrogenase A LDHA which catalyzes the last key step in glycolysis was identified as a direct target of miR-34a; Silencing of LDHA or introduction of miR-34a significantly attenuated colony formation ability and invasive capacity of SiHa and HeLa cells and these effects were fully compromised by reintroduction of LDHA ;; breast cancer;colon cancer;cervical and endocervical cancer hsa-miR-20a-5p LDHB 0.854326758727003 5.04256669663285e-07 -0.47508964220614 0.00689354591337264 miRNAWalker2_validate -0.134243847858072 0.00717756019266304 NA NA NA hsa-miR-19b-3p LDLR 0.601279551368824 0.00016685097085251 -1.46283255505596 2.87241408741105e-21 miRNAWalker2_validate -0.208497070123314 2.12468126364113e-05 NA NA NA hsa-miR-20a-5p LDLR 0.854326758727003 5.04256669663285e-07 -1.46283255505596 2.87241408741105e-21 miRNATAP -0.213073152973632 3.02998935851509e-06 NA NA NA hsa-miR-20b-5p LDLR 0.457668023910379 0.0285865211936156 -1.46283255505596 2.87241408741105e-21 miRNATAP -0.176421337809616 2.54867427803803e-06 NA NA NA hsa-miR-224-3p LDLR 1.40770116795301 1.31426607144612e-08 -1.46283255505596 2.87241408741105e-21 mirMAP -0.106658812679911 0.000778317925943514 NA NA NA hsa-miR-20a-5p LDLRAP1 0.854326758727003 5.04256669663285e-07 -0.353413008060407 0.000695104372865604 MirTarget;miRNATAP -0.130850616126016 8.43098861239753e-06 NA NA NA hsa-miR-15a-5p LDOC1L 0.349521211668244 0.000770735998804736 -0.661168203841977 0.000563897974207453 mirMAP -0.399256319714064 9.44320856019983e-06 NA NA NA hsa-miR-20a-5p LDOC1L 0.854326758727003 5.04256669663285e-07 -0.661168203841977 0.000563897974207453 mirMAP -0.117537854203184 0.0316298828109269 NA NA NA hsa-miR-455-3p LDOC1L -1.3998033821095 5.72010709806871e-17 -0.661168203841977 0.000563897974207453 MirTarget -0.188896315031476 0.000460152009941043 NA NA NA hsa-miR-455-5p LEF1 -0.270546034117157 0.0581320703577731 2.65801616612257 2.07740338608884e-15 miRanda -0.352774280915771 0.00297563964985378 NA NA NA hsa-miR-21-5p LEMD3 1.51084295924322 1.54551622173259e-34 -0.241034061384027 0.00152124310234342 miRNATAP -0.124267537760017 6.15901201616457e-06 NA NA NA hsa-miR-148a-3p LENG8 -0.748702855596996 3.93313343865641e-07 0.75934588482606 9.40854812638038e-12 miRNATAP -0.17903107934032 1.24127378758558e-06 NA NA NA hsa-miR-455-3p LENG8 -1.3998033821095 5.72010709806871e-17 0.75934588482606 9.40854812638038e-12 MirTarget;PITA;miRNATAP -0.116695607696744 0.000254236189157267 NA NA NA hsa-miR-181a-5p LEPROT 0.250113435902954 0.0551933249319293 -0.766289999290305 0.00143475208504872 MirTarget -0.285831155204884 0.00158479362908884 NA NA NA hsa-miR-181b-5p LEPROT 0.488256489401108 0.00105321129419701 -0.766289999290305 0.00143475208504872 MirTarget -0.246459837803959 0.00174384932132757 NA NA NA hsa-miR-222-3p LEPROT 1.08574156066353 1.76407192348131e-11 -0.766289999290305 0.00143475208504872 MirTarget -0.271646688038311 0.000128138029333047 NA NA NA hsa-miR-192-5p LEPROTL1 -0.50188499512787 0.00344713341196035 -0.22955247257624 0.0167550852758737 miRNAWalker2_validate -0.146250428336066 4.86021306220363e-08 NA NA NA hsa-miR-30e-5p LEPROTL1 -0.627815042856657 3.02205690184908e-10 -0.22955247257624 0.0167550852758737 mirMAP -0.149358493044813 0.00123415074582784 NA NA NA hsa-miR-455-5p LETM2 -0.270546034117157 0.0581320703577731 0.572116813787658 0.00326323709502078 miRanda -0.262617042726724 7.81230804776031e-05 NA NA NA hsa-miR-455-5p LGALS9 -0.270546034117157 0.0581320703577731 0.033344917867792 0.84689606594587 MirTarget;miRanda -0.274205297320052 2.76578389038335e-06 NA NA NA hsa-miR-455-5p LGALS9C -0.270546034117157 0.0581320703577731 -0.132635669930986 0.621775770749311 miRanda -0.217867995573039 0.0179292453972865 NA NA NA hsa-miR-455-3p LGI2 -1.3998033821095 5.72010709806871e-17 0.878946059281759 0.00041399405246749 mirMAP -0.475063230743867 4.34173465367369e-12 NA NA NA hsa-miR-132-3p LGR4 0.323796239695997 0.00272093067935091 -0.788391850340954 1.17910105860239e-08 miRNAWalker2_validate -0.252094168312373 7.03155021294597e-05 NA NA NA hsa-miR-34a-5p LGR4 1.03694231790865 5.74864019540594e-14 -0.788391850340954 1.17910105860239e-08 MirTarget;miRNATAP -0.386519166308727 1.01490746697299e-16 NA NA NA hsa-miR-132-3p LGSN 0.323796239695997 0.00272093067935091 -2.52633123363191 1.49953406371445e-10 mirMAP -0.995206659643076 3.55027449966447e-08 NA NA NA hsa-miR-182-5p LGSN 1.96601340710222 4.39326175603633e-09 -2.52633123363191 1.49953406371445e-10 MirTarget -0.306995556178137 6.43981048542477e-08 NA NA NA hsa-miR-224-3p LGSN 1.40770116795301 1.31426607144612e-08 -2.52633123363191 1.49953406371445e-10 mirMAP -0.191745186752344 0.0153587433910606 NA NA NA hsa-miR-409-3p LGSN -0.499649792570937 0.0526751181520117 -2.52633123363191 1.49953406371445e-10 miRNATAP -0.185831316863835 0.0147822610571387 NA NA NA hsa-miR-146b-5p LHFP 0.419719546795449 0.0457375823220155 -0.123835706003002 0.4719215089579 miRanda -0.11145692739372 0.00512961656977033 NA NA NA hsa-miR-192-5p LHFP -0.50188499512787 0.00344713341196035 -0.123835706003002 0.4719215089579 miRNAWalker2_validate -0.409168721965413 2.13895611689874e-18 NA NA NA hsa-miR-30e-5p LHFPL2 -0.627815042856657 3.02205690184908e-10 0.0860745571518011 0.643643601257953 MirTarget;mirMAP -0.459077236043495 2.2966756088302e-07 NA NA NA hsa-miR-455-5p LHFPL2 -0.270546034117157 0.0581320703577731 0.0860745571518011 0.643643601257953 miRanda -0.327424341137219 1.8905024597456e-07 NA NA NA hsa-miR-34a-5p LHX2 1.03694231790865 5.74864019540594e-14 -2.96551900124184 3.14609698542522e-26 miRNATAP -0.49225993188251 1.24658804198679e-06 NA NA NA hsa-miR-194-5p LHX6 -0.292530160992458 0.0996141384876663 0.558194088934288 0.0143299162908477 miRNATAP -0.300837397315603 1.29194538602621e-06 NA NA NA hsa-miR-20a-5p LHX6 0.854326758727003 5.04256669663285e-07 0.558194088934288 0.0143299162908477 MirTarget;miRNATAP -0.152320765043608 0.0186992156229048 NA NA NA hsa-miR-19b-3p LHX9 0.601279551368824 0.00016685097085251 -0.611454506104065 0.137411458344879 mirMAP -0.49193631152585 7.7197568143221e-05 NA NA NA hsa-miR-20a-5p LIF 0.854326758727003 5.04256669663285e-07 -0.722255918484923 0.0325743370034823 miRNATAP -0.249921952355473 0.00917214825956543 NA NA NA hsa-miR-455-3p LIF -1.3998033821095 5.72010709806871e-17 -0.722255918484923 0.0325743370034823 mirMAP -0.372145729781505 8.23233339597696e-05 NA NA NA hsa-miR-182-5p LIFR 1.96601340710222 4.39326175603633e-09 -3.54791005337671 1.62449725318617e-42 mirMAP -0.153695282447375 0.000176299649114969 NA NA NA hsa-miR-19b-3p LIFR 0.601279551368824 0.00016685097085251 -3.54791005337671 1.62449725318617e-42 mirMAP -0.360267832609079 3.58944375683591e-05 NA NA NA hsa-miR-21-5p LIFR 1.51084295924322 1.54551622173259e-34 -3.54791005337671 1.62449725318617e-42 miRNAWalker2_validate -0.970873248845757 3.02875243005404e-22 NA NA NA hsa-miR-221-3p LIFR 1.12244756358612 3.48370308238012e-13 -3.54791005337671 1.62449725318617e-42 miRNATAP -0.543309890221884 4.42342545438935e-10 NA NA NA hsa-miR-222-3p LIFR 1.08574156066353 1.76407192348131e-11 -3.54791005337671 1.62449725318617e-42 miRNATAP -0.427882092016526 3.76311937486636e-07 NA NA NA hsa-miR-224-3p LIFR 1.40770116795301 1.31426607144612e-08 -3.54791005337671 1.62449725318617e-42 mirMAP -0.26591755475668 2.05976172840671e-06 NA NA NA hsa-miR-132-3p LIG4 0.323796239695997 0.00272093067935091 -0.526853993165358 1.7283249935127e-05 miRNAWalker2_validate -0.286338573501028 2.33581224559294e-07 NA NA NA hsa-miR-181a-5p LIG4 0.250113435902954 0.0551933249319293 -0.526853993165358 1.7283249935127e-05 MirTarget -0.152469243859901 0.000983114819477961 NA NA NA hsa-miR-181b-5p LIG4 0.488256489401108 0.00105321129419701 -0.526853993165358 1.7283249935127e-05 MirTarget -0.156220402450582 9.96587903366717e-05 NA NA NA hsa-miR-455-5p LILRA6 -0.270546034117157 0.0581320703577731 -1.12267947155802 6.17691121871655e-08 miRanda -0.266195609381599 0.000211838889708286 NA NA NA hsa-miR-20a-5p LIMA1 0.854326758727003 5.04256669663285e-07 -0.0238020816121152 0.838430946766389 MirTarget;miRNATAP -0.103290213829126 0.00169430507389475 NA NA NA hsa-miR-146b-5p LIMCH1 0.419719546795449 0.0457375823220155 -1.12216634710894 4.98886861121512e-07 miRanda -0.255175481442717 8.92102232946067e-07 NA NA NA hsa-miR-192-5p LIMCH1 -0.50188499512787 0.00344713341196035 -1.12216634710894 4.98886861121512e-07 miRNAWalker2_validate -0.441869246854339 1.6031039768036e-12 NA NA NA hsa-miR-194-5p LIMCH1 -0.292530160992458 0.0996141384876663 -1.12216634710894 4.98886861121512e-07 MirTarget -0.468824149547109 7.0057102923953e-15 NA NA NA hsa-miR-19b-3p LIMCH1 0.601279551368824 0.00016685097085251 -1.12216634710894 4.98886861121512e-07 miRNATAP -0.408859505456155 1.4178520565013e-09 NA NA NA hsa-miR-132-3p LIMD1 0.323796239695997 0.00272093067935091 0.242601733850809 0.0190447425498849 mirMAP -0.174395926009479 0.000187337688040687 NA NA NA hsa-miR-146a-5p LIMD1 -0.742958238440575 0.000765983177482633 0.242601733850809 0.0190447425498849 mirMAP -0.125293595298433 2.13163126213186e-08 NA NA NA hsa-miR-192-5p LIMD2 -0.50188499512787 0.00344713341196035 -0.214037676050721 0.282021903246009 mirMAP -0.292953214544803 1.41555874438372e-07 NA NA NA hsa-miR-34a-5p LIMD2 1.03694231790865 5.74864019540594e-14 -0.214037676050721 0.282021903246009 MirTarget;miRNATAP -0.339678901022431 4.91445009381935e-07 NA NA NA hsa-miR-27b-3p LIMK1 -0.823491817819754 9.20935302746823e-14 1.07371358822101 6.47096899356271e-13 MirTarget;miRNATAP -0.482019268690296 6.45470221361992e-14 NA NA NA hsa-miR-194-5p LIMK2 -0.292530160992458 0.0996141384876663 0.891712220823075 3.4499668982677e-09 miRNATAP -0.262212351957116 2.41558338582082e-10 NA NA NA hsa-miR-27b-3p LIMK2 -0.823491817819754 9.20935302746823e-14 0.891712220823075 3.4499668982677e-09 miRNATAP -0.320719355848057 1.00103636289881e-06 NA NA NA hsa-miR-30c-5p LIMK2 -0.432111642767632 0.000159764714931007 0.891712220823075 3.4499668982677e-09 mirMAP -0.25606793908615 8.5175999615255e-05 NA NA NA hsa-miR-192-5p LIMS1 -0.50188499512787 0.00344713341196035 -0.53231394759922 0.0185999713916091 miRNAWalker2_validate;MirTarget -0.154960037196009 0.0159385177083704 NA NA NA hsa-miR-30b-5p LIMS1 -0.54056186708617 2.44688760798341e-05 -0.53231394759922 0.0185999713916091 MirTarget -0.213432199674479 0.0130105734385778 NA NA NA hsa-miR-30b-5p LIN28B -0.54056186708617 2.44688760798341e-05 2.26854994708754 4.69141976850235e-05 MirTarget;miRNATAP -1.03878147062526 8.50979827225323e-07 NA NA NA hsa-miR-181a-5p LIN7A 0.250113435902954 0.0551933249319293 -0.539444523114043 0.000887680837455538 mirMAP -0.422890784477737 1.32508928604542e-12 NA NA NA hsa-miR-181b-5p LIN7A 0.488256489401108 0.00105321129419701 -0.539444523114043 0.000887680837455538 mirMAP -0.418821397200742 3.61277916908684e-16 NA NA NA hsa-miR-181a-5p LIN7C 0.250113435902954 0.0551933249319293 -0.778211251236792 5.38883335125652e-24 mirMAP;miRNATAP -0.178699096967302 2.52136057308277e-09 NA NA NA hsa-miR-181b-5p LIN7C 0.488256489401108 0.00105321129419701 -0.778211251236792 5.38883335125652e-24 mirMAP;miRNATAP -0.178250132772279 5.88494625460495e-12 NA NA NA hsa-miR-21-5p LIN7C 1.51084295924322 1.54551622173259e-34 -0.778211251236792 5.38883335125652e-24 miRNAWalker2_validate -0.316945336013872 1.32056596586162e-30 NA NA NA hsa-miR-215-5p LIN9 -0.981544773246509 3.14452272477156e-05 1.53758985014096 2.9412533171642e-23 miRNAWalker2_validate -0.100983196342572 0.0025516213728218 NA NA NA hsa-miR-15a-5p LITAF 0.349521211668244 0.000770735998804736 -0.221177898256862 0.0579742828236894 MirTarget;miRNATAP -0.196225518402421 0.000333980386211782 NA NA NA hsa-miR-27b-3p LITAF -0.823491817819754 9.20935302746823e-14 -0.221177898256862 0.0579742828236894 MirTarget;miRNATAP -0.141356603870439 0.00484003921524013 NA NA NA hsa-miR-30e-5p LIX1L -0.627815042856657 3.02205690184908e-10 0.478716447740913 2.70006748422122e-06 mirMAP -0.113068594465487 0.0231991768324058 NA NA NA hsa-miR-30c-5p LLPH -0.432111642767632 0.000159764714931007 0.216128578559967 0.00083576925199987 miRNAWalker2_validate -0.100537660851356 0.000240405930954337 NA NA NA hsa-miR-181a-5p LMAN1 0.250113435902954 0.0551933249319293 -0.935085324207848 9.35847745172939e-17 MirTarget -0.242014942580514 2.09928616290784e-08 NA NA NA hsa-miR-181b-5p LMAN1 0.488256489401108 0.00105321129419701 -0.935085324207848 9.35847745172939e-17 MirTarget -0.219979209122281 4.47020306760259e-09 NA NA NA hsa-miR-34a-5p LMAN1 1.03694231790865 5.74864019540594e-14 -0.935085324207848 9.35847745172939e-17 MirTarget;miRNATAP -0.138952384639345 0.000510652356964225 NA NA NA hsa-miR-17-3p LMBR1 0.410352776142368 0.00422200500748636 -0.126617891799222 0.154766250119006 MirTarget -0.161658322896383 5.3482325692315e-08 NA NA NA hsa-miR-19b-3p LMBR1 0.601279551368824 0.00016685097085251 -0.126617891799222 0.154766250119006 mirMAP -0.129440466699939 1.19496861863765e-06 NA NA NA hsa-miR-21-5p LMBR1 1.51084295924322 1.54551622173259e-34 -0.126617891799222 0.154766250119006 miRNAWalker2_validate -0.12248170979845 0.000141864653574036 NA NA NA hsa-miR-30b-5p LMBR1 -0.54056186708617 2.44688760798341e-05 -0.126617891799222 0.154766250119006 MirTarget -0.120190208313972 0.000329459031354728 NA NA NA hsa-miR-181a-5p LMBRD2 0.250113435902954 0.0551933249319293 -0.379556645489973 0.0216178458484519 MirTarget;mirMAP -0.329167342799075 7.80805811076529e-08 NA NA NA hsa-miR-181b-5p LMBRD2 0.488256489401108 0.00105321129419701 -0.379556645489973 0.0216178458484519 MirTarget;mirMAP -0.27256662376182 3.31195134854114e-07 NA NA NA hsa-miR-17-3p LMLN 0.410352776142368 0.00422200500748636 -0.166069500007594 0.301560342444305 MirTarget -0.325821291687845 1.21158837273948e-09 NA NA NA hsa-miR-19b-3p LMLN 0.601279551368824 0.00016685097085251 -0.166069500007594 0.301560342444305 MirTarget;miRNATAP -0.228642647664441 2.21771429056829e-06 NA NA NA hsa-miR-27b-3p LMLN -0.823491817819754 9.20935302746823e-14 -0.166069500007594 0.301560342444305 MirTarget -0.225063595203432 0.00110812462534771 NA NA NA hsa-miR-455-5p LMLN -0.270546034117157 0.0581320703577731 -0.166069500007594 0.301560342444305 miRanda -0.304579249820639 1.87052551020603e-08 NA NA NA hsa-miR-192-5p LMNB2 -0.50188499512787 0.00344713341196035 1.15533579106848 2.8635849155846e-19 miRNAWalker2_validate -0.286225570514038 1.00336825060293e-14 NA NA NA hsa-miR-215-5p LMNB2 -0.981544773246509 3.14452272477156e-05 1.15533579106848 2.8635849155846e-19 miRNAWalker2_validate -0.138983534889371 3.4167299463477e-07 NA NA NA hsa-miR-182-5p LMOD1 1.96601340710222 4.39326175603633e-09 0.223610478528773 0.336694263695608 miRNATAP -0.15349044576768 2.9852674127441e-06 NA NA NA hsa-miR-148a-3p LMX1B -0.748702855596996 3.93313343865641e-07 0.364650040807185 0.351279745807035 mirMAP -0.833948271652518 2.48999705809489e-11 NA NA NA hsa-miR-15a-5p LMX1B 0.349521211668244 0.000770735998804736 0.364650040807185 0.351279745807035 mirMAP -0.593140027335857 0.00125477553873725 NA NA NA hsa-miR-34a-5p LMX1B 1.03694231790865 5.74864019540594e-14 0.364650040807185 0.351279745807035 mirMAP -0.310974060122044 0.0207312391899379 NA NA NA hsa-miR-505-5p LMX1B -0.768282569967001 1.14662846595407e-05 0.364650040807185 0.351279745807035 mirMAP -0.535610633945186 5.2594516428574e-07 NA NA NA hsa-miR-181a-5p LNPEP 0.250113435902954 0.0551933249319293 0.0381901216213942 0.796318936192664 mirMAP -0.157682053104731 0.0043969449750391 NA NA NA hsa-miR-181b-5p LNPEP 0.488256489401108 0.00105321129419701 0.0381901216213942 0.796318936192664 mirMAP -0.123213166021816 0.0105853812238958 NA NA NA hsa-miR-19b-3p LNPEP 0.601279551368824 0.00016685097085251 0.0381901216213942 0.796318936192664 MirTarget;mirMAP;miRNATAP -0.271073926616889 7.39091857601859e-10 NA NA NA hsa-miR-20a-5p LNPEP 0.854326758727003 5.04256669663285e-07 0.0381901216213942 0.796318936192664 mirMAP -0.237736137811097 7.7153738054967e-09 NA NA NA hsa-miR-30b-5p LNPEP -0.54056186708617 2.44688760798341e-05 0.0381901216213942 0.796318936192664 mirMAP -0.247575148181675 8.23583416823928e-06 NA NA NA hsa-miR-132-3p LONP2 0.323796239695997 0.00272093067935091 -1.15752181481711 1.20062079208437e-15 mirMAP -0.341700631252572 3.65544665995624e-07 NA NA NA hsa-miR-17-3p LONP2 0.410352776142368 0.00422200500748636 -1.15752181481711 1.20062079208437e-15 mirMAP -0.228049019517775 6.38024624231695e-06 NA NA NA hsa-miR-181a-5p LONP2 0.250113435902954 0.0551933249319293 -1.15752181481711 1.20062079208437e-15 mirMAP -0.394977883487647 5.4127484003815e-13 NA NA NA hsa-miR-181b-5p LONP2 0.488256489401108 0.00105321129419701 -1.15752181481711 1.20062079208437e-15 mirMAP -0.38913258616929 1.6122770850947e-16 NA NA NA hsa-miR-19b-3p LONRF1 0.601279551368824 0.00016685097085251 -1.11533120137683 3.91786752222707e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.164699754455545 7.66996887214623e-05 NA NA NA hsa-miR-148a-3p LONRF2 -0.748702855596996 3.93313343865641e-07 -1.03606777199417 0.00951581549876641 mirMAP -0.681330104510286 1.38533515320194e-07 NA NA NA hsa-miR-30e-5p LONRF2 -0.627815042856657 3.02205690184908e-10 -1.03606777199417 0.00951581549876641 mirMAP -0.470221288008067 0.0152860267762769 NA NA NA hsa-miR-455-3p LONRF2 -1.3998033821095 5.72010709806871e-17 -1.03606777199417 0.00951581549876641 mirMAP -0.330241032629169 0.00329307677314027 NA NA NA hsa-miR-19b-3p LONRF3 0.601279551368824 0.00016685097085251 -0.69388697643543 3.2523505908316e-05 MirTarget -0.225712627557617 8.73390279793025e-06 NA NA NA hsa-miR-27b-3p LOX -0.823491817819754 9.20935302746823e-14 1.12460456664183 4.86114109294809e-06 miRNATAP -0.30480513226165 0.0044372476136409 NA NA NA hsa-miR-455-3p LOX -1.3998033821095 5.72010709806871e-17 1.12460456664183 4.86114109294809e-06 PITA;miRNATAP -0.18750511581047 0.00723327461313756 NA NA NA hsa-miR-455-5p LOX -0.270546034117157 0.0581320703577731 1.12460456664183 4.86114109294809e-06 miRanda;miRNATAP -0.183471186613627 0.0315164022492138 NA NA NA hsa-miR-192-5p LOXL2 -0.50188499512787 0.00344713341196035 1.63969538101948 3.81782645914369e-28 miRNAWalker2_validate -0.406183915121298 4.54599624471813e-21 NA NA NA hsa-miR-34a-5p LOXL3 1.03694231790865 5.74864019540594e-14 0.0107326013149585 0.946699725545573 MirTarget;miRNATAP -0.1156422280138 0.0358822090343973 NA NA NA hsa-miR-455-5p LOXL3 -0.270546034117157 0.0581320703577731 0.0107326013149585 0.946699725545573 miRanda -0.24694363207728 5.66890566118432e-06 NA NA NA hsa-miR-29c-3p LOXL4 -1.4367517608807 1.61767774905781e-21 0.557577293252236 0.172258024536537 MirTarget;miRNATAP -0.360787796439132 0.00408832099008522 NA NA NA hsa-miR-21-5p LPA 1.51084295924322 1.54551622173259e-34 -3.96486166434916 7.78567900365653e-23 MirTarget -1.32367982780015 6.65823633941695e-19 26098771 DNA microarray and real-time PCR analyses further demonstrated that LPA up-regulated the oncomiR miR-21 through an LPA1/Pi3K/ZEB1-dependent mechanism breast cancer hsa-miR-27b-3p LPCAT1 -0.823491817819754 9.20935302746823e-14 0.979301235361667 4.14787419947705e-08 MirTarget -0.601395945528285 1.81668876458417e-15 NA NA NA hsa-miR-30e-5p LPGAT1 -0.627815042856657 3.02205690184908e-10 0.635448072301032 7.01404383798336e-07 MirTarget -0.167271945999 0.00757443736821865 NA NA NA hsa-miR-19b-3p LPIN1 0.601279551368824 0.00016685097085251 -0.135731511477539 0.370548383872963 mirMAP -0.201948965590896 9.55566821308563e-06 NA NA NA hsa-miR-21-5p LPIN2 1.51084295924322 1.54551622173259e-34 -1.28920874369498 9.96607683916703e-16 mirMAP -0.32154832087112 8.22951864870956e-08 NA NA NA hsa-miR-29c-3p LPL -1.4367517608807 1.61767774905781e-21 2.28010324035066 5.5045312934226e-24 miRNATAP -0.166518285403257 0.0239289185831175 NA NA NA hsa-miR-15a-5p LPP 0.349521211668244 0.000770735998804736 -0.386324215418135 0.00226265643427216 mirMAP;miRNATAP -0.196890730544979 0.000958533751318843 NA NA NA hsa-miR-19b-3p LPP 0.601279551368824 0.00016685097085251 -0.386324215418135 0.00226265643427216 MirTarget;mirMAP;miRNATAP -0.215458419125127 1.37771284077059e-08 NA NA NA hsa-miR-20a-5p LPP 0.854326758727003 5.04256669663285e-07 -0.386324215418135 0.00226265643427216 mirMAP -0.195254600915517 3.60365794828199e-08 NA NA NA hsa-miR-20b-5p LPP 0.457668023910379 0.0285865211936156 -0.386324215418135 0.00226265643427216 mirMAP -0.111590416468544 0.000147859602220123 NA NA NA hsa-miR-194-5p LPXN -0.292530160992458 0.0996141384876663 -0.365580939505187 0.000135302046148433 MirTarget -0.128047119920471 9.77801222190598e-07 NA NA NA hsa-miR-181a-5p LRAT 0.250113435902954 0.0551933249319293 -4.13158473453449 2.38539906898597e-44 mirMAP -0.28992958599228 0.0195189244400401 NA NA NA hsa-miR-181b-5p LRAT 0.488256489401108 0.00105321129419701 -4.13158473453449 2.38539906898597e-44 mirMAP -0.350904560479799 0.00111585158564376 NA NA NA hsa-miR-17-3p LRCH2 0.410352776142368 0.00422200500748636 0.138549001076077 0.509005945461395 MirTarget -0.143476230134509 0.0443555929758973 NA NA NA hsa-miR-194-5p LRCH2 -0.292530160992458 0.0996141384876663 0.138549001076077 0.509005945461395 MirTarget -0.359594482929451 1.85297135962521e-10 NA NA NA hsa-miR-148a-3p LRFN1 -0.748702855596996 3.93313343865641e-07 0.250715581306462 0.275069133493013 miRNATAP -0.511549192387535 2.7107957688765e-12 NA NA NA hsa-miR-15a-5p LRIG1 0.349521211668244 0.000770735998804736 -0.493686164714059 8.66910284289362e-05 MirTarget -0.139582932846422 0.0193351369930091 NA NA NA hsa-miR-19b-3p LRIG1 0.601279551368824 0.00016685097085251 -0.493686164714059 8.66910284289362e-05 MirTarget -0.110784533701139 0.00392692460354206 NA NA NA hsa-miR-20a-5p LRIG1 0.854326758727003 5.04256669663285e-07 -0.493686164714059 8.66910284289362e-05 MirTarget -0.13207684088835 0.000216970712207246 25960225 miR 20a mediates temozolomide resistance in glioblastoma cells via negatively regulating LRIG1 expression; Here we aimed to elucidate the relationship between miR-20a its predicted target genes leucine-rich repeats and immunoglobulin-like domains 1 LRIG1 and TMZ resistance in GBM; Real-time PCR or western blot was used to measure the levels of miR-20a and LRIG1; The interaction between miR-20a and its predicted target gene LRIG1 was confirmed by 3'-UTR dual-luciferase reporter assay; MiR-20a was highly expressed and LRIG1 lowly expressed in U251/TMZ cells; The levels of LRIG1 were inversely related to miR-20a levels; And the luciferase reporter assays showed that miR-20a directly targeted the 3'UTR of LRIG1; In addition functional knock-down of LRIG1 by gene specific siRNA reversed the effect of miR-20a inhibitor; MiR-20a mediated TMZ-resistance in glioblastoma cells through negatively regulating LRIG1 expression which suggesting that miR-20a and LRIG1 would be potential therapeutic targets for glioma therapy drug resistance glioblastoma hsa-miR-455-5p LRP12 -0.270546034117157 0.0581320703577731 0.456838554349231 0.0312242549766872 miRanda -0.372527973032817 2.16310178190115e-07 NA NA NA hsa-miR-455-5p LRP1B -0.270546034117157 0.0581320703577731 -1.66988275957729 9.68113918882022e-05 miRanda -0.566348337580109 0.000119186814695954 NA NA NA hsa-miR-15a-5p LRP6 0.349521211668244 0.000770735998804736 -0.374410866893442 0.0013487864538849 miRNATAP -0.161392611628997 0.00341573687442505 NA NA NA hsa-miR-181a-5p LRP6 0.250113435902954 0.0551933249319293 -0.374410866893442 0.0013487864538849 mirMAP -0.131385397631165 0.00276797465432674 NA NA NA hsa-miR-181b-5p LRP6 0.488256489401108 0.00105321129419701 -0.374410866893442 0.0013487864538849 mirMAP -0.118078225864745 0.00198310355409659 NA NA NA hsa-miR-221-3p LRP6 1.12244756358612 3.48370308238012e-13 -0.374410866893442 0.0013487864538849 miRNAWalker2_validate -0.100566445726281 0.00520193003801261 NA NA NA hsa-miR-192-5p LRP8 -0.50188499512787 0.00344713341196035 0.86386782073676 0.000478944145486285 miRNAWalker2_validate -0.721581622511402 8.95123147358363e-28 NA NA NA hsa-miR-215-5p LRP8 -0.981544773246509 3.14452272477156e-05 0.86386782073676 0.000478944145486285 miRNAWalker2_validate -0.231620165601558 4.5838044868649e-06 NA NA NA hsa-miR-455-5p LRP8 -0.270546034117157 0.0581320703577731 0.86386782073676 0.000478944145486285 miRanda -0.417830325022571 7.22908773546133e-07 NA NA NA hsa-miR-192-5p LRRC10B -0.50188499512787 0.00344713341196035 1.39185459151367 1.50898746252049e-10 MirTarget -0.218431101484903 0.000509451021313216 NA NA NA hsa-miR-215-5p LRRC10B -0.981544773246509 3.14452272477156e-05 1.39185459151367 1.50898746252049e-10 MirTarget -0.103646807107519 0.0229876803172079 NA NA NA hsa-miR-17-3p LRRC15 0.410352776142368 0.00422200500748636 -0.934213828577622 0.00924441278375808 mirMAP -0.449246926254015 0.00022852366492109 NA NA NA hsa-miR-122-3p LRRC17 -1.75369011054591 1.52070648599898e-11 -0.262041137799498 0.147975667075437 MirTarget -0.12675035833306 0.000119575449421297 NA NA NA hsa-miR-455-5p LRRC25 -0.270546034117157 0.0581320703577731 -1.03829692077221 2.61078428889978e-09 miRanda -0.271707855490645 6.80821097502762e-06 NA NA NA hsa-miR-34a-5p LRRC28 1.03694231790865 5.74864019540594e-14 -0.468260026227046 0.000256762924949485 miRNAWalker2_validate -0.180343797934304 4.09472684521969e-05 NA NA NA hsa-miR-146b-5p LRRC32 0.419719546795449 0.0457375823220155 -0.330671720417453 0.0453871645139858 miRanda -0.1148073908794 0.00270494336130459 NA NA NA hsa-miR-34a-5p LRRC40 1.03694231790865 5.74864019540594e-14 -0.846124981301566 3.49820139027552e-13 miRNAWalker2_validate;MirTarget -0.135124612141812 0.000980526830291855 NA NA NA hsa-miR-20a-5p LRRC55 0.854326758727003 5.04256669663285e-07 -3.40869096246176 2.95454085746275e-31 MirTarget -0.356420989120398 6.52934963704133e-05 NA NA NA hsa-miR-21-5p LRRC55 1.51084295924322 1.54551622173259e-34 -3.40869096246176 2.95454085746275e-31 mirMAP -0.782400175562664 4.02887388179652e-12 NA NA NA hsa-miR-34a-5p LRRC55 1.03694231790865 5.74864019540594e-14 -3.40869096246176 2.95454085746275e-31 MirTarget;miRNATAP -0.724919101750224 9.05247777542566e-12 NA NA NA hsa-miR-30b-5p LRRC58 -0.54056186708617 2.44688760798341e-05 -0.0356408411546276 0.759787480699555 mirMAP -0.139156170429293 0.00154612559973597 NA NA NA hsa-miR-15a-5p LRRC7 0.349521211668244 0.000770735998804736 -2.0700468671659 2.45263430400919e-10 MirTarget -0.407645725095327 0.00971030056495797 NA NA NA hsa-miR-34a-5p LRRC7 1.03694231790865 5.74864019540594e-14 -2.0700468671659 2.45263430400919e-10 MirTarget -0.51485869619252 6.288174405368e-06 NA NA NA hsa-miR-146b-5p LRRC8B 0.419719546795449 0.0457375823220155 -0.654336651065766 0.000402530838893617 miRanda -0.113517571791348 0.00846878215128742 NA NA NA hsa-miR-148a-3p LRRC8B -0.748702855596996 3.93313343865641e-07 -0.654336651065766 0.000402530838893617 mirMAP -0.436351948687831 1.51375647413546e-13 NA NA NA hsa-miR-192-5p LRRC8C -0.50188499512787 0.00344713341196035 -0.320611805711573 0.0133620124738904 miRNAWalker2_validate -0.27353820000798 1.69534848749154e-14 NA NA NA hsa-miR-181a-5p LRRC8D 0.250113435902954 0.0551933249319293 0.302080319292119 0.000965409775769997 MirTarget -0.159546109342752 2.87402866666309e-06 NA NA NA hsa-miR-181b-5p LRRC8D 0.488256489401108 0.00105321129419701 0.302080319292119 0.000965409775769997 MirTarget -0.150735024599196 3.49014390500572e-07 NA NA NA hsa-miR-30b-5p LRRC8D -0.54056186708617 2.44688760798341e-05 0.302080319292119 0.000965409775769997 MirTarget;miRNATAP -0.150305159940317 1.31572700813742e-05 NA NA NA hsa-miR-146b-5p LRRC8E 0.419719546795449 0.0457375823220155 0.000973930045667259 0.996613364046769 miRanda -0.115779762186135 0.0295072207368457 NA NA NA hsa-miR-221-3p LRRCC1 1.12244756358612 3.48370308238012e-13 0.0427198654794261 0.831958818301209 MirTarget -0.20232256254731 0.00103300782777049 NA NA NA hsa-miR-222-3p LRRCC1 1.08574156066353 1.76407192348131e-11 0.0427198654794261 0.831958818301209 MirTarget -0.153205046941886 0.00978803361027935 NA NA NA hsa-miR-181a-5p LRRFIP1 0.250113435902954 0.0551933249319293 -0.587622691682438 1.09608882717065e-10 MirTarget -0.120884812720207 0.00050350460762621 NA NA NA hsa-miR-181b-5p LRRFIP1 0.488256489401108 0.00105321129419701 -0.587622691682438 1.09608882717065e-10 MirTarget -0.122870430539651 4.58252949580185e-05 NA NA NA hsa-miR-21-5p LRRFIP1 1.51084295924322 1.54551622173259e-34 -0.587622691682438 1.09608882717065e-10 miRNAWalker2_validate;miRTarBase -0.17386208053287 2.08191255544983e-07 19559015 MicroRNA 21 targets LRRFIP1 and contributes to VM 26 resistance in glioblastoma multiforme; We further identified and validated LRRFIP1 whose product is an inhibitor of NF-kappaB signaling as a direct target gene of miR-21 drug resistance glioblastoma hsa-miR-15a-5p LRRK1 0.349521211668244 0.000770735998804736 -0.717203025303643 0.000298203132615988 MirTarget -0.199067018619531 0.0344667268950528 NA NA NA hsa-miR-455-5p LRRK1 -0.270546034117157 0.0581320703577731 -0.717203025303643 0.000298203132615988 miRanda -0.288891238787231 2.07489579243494e-05 NA NA NA hsa-miR-15a-5p LRRN3 0.349521211668244 0.000770735998804736 -3.40205098548004 3.99371153788303e-36 MirTarget;miRNATAP -0.520377168372387 0.000184408048134423 NA NA NA hsa-miR-192-5p LSAMP -0.50188499512787 0.00344713341196035 -0.941773692937136 0.00579276461338465 MirTarget -0.723497447820975 1.54136158700982e-14 NA NA NA hsa-miR-20a-5p LSAMP 0.854326758727003 5.04256669663285e-07 -0.941773692937136 0.00579276461338465 miRNATAP -0.28492095285676 0.00329343734899716 NA NA NA hsa-miR-215-5p LSAMP -0.981544773246509 3.14452272477156e-05 -0.941773692937136 0.00579276461338465 MirTarget -0.140652368063076 0.0453363401265304 NA NA NA hsa-miR-29c-3p LSM11 -1.4367517608807 1.61767774905781e-21 0.758646663868328 2.93737544855881e-13 miRNATAP -0.307233619430775 6.94015604987773e-23 NA NA NA hsa-miR-29c-3p LSM14B -1.4367517608807 1.61767774905781e-21 0.435904204745383 1.7100051386832e-07 mirMAP;miRNATAP -0.175609913381342 3.88890357475977e-12 NA NA NA hsa-miR-29c-3p LSS -1.4367517608807 1.61767774905781e-21 0.143989311838791 0.343379084936067 mirMAP -0.101348240504897 0.0301794940816033 NA NA NA hsa-miR-455-5p LTA -0.270546034117157 0.0581320703577731 0.541951284853821 0.0223951539504111 miRanda -0.25737244887129 0.00153882123125588 NA NA NA hsa-miR-224-3p LTBP1 1.40770116795301 1.31426607144612e-08 -1.32612816740388 3.79930867511623e-09 MirTarget -0.107927802475616 0.0163560348383435 NA NA NA hsa-miR-20a-5p LUZP1 0.854326758727003 5.04256669663285e-07 0.206618637628015 0.0231918761468685 mirMAP;miRNATAP -0.119012701019953 3.06591851116491e-06 NA NA NA hsa-miR-181a-5p LUZP2 0.250113435902954 0.0551933249319293 1.08272464345489 0.00317141578198537 mirMAP -0.403563052531686 0.00349309343616157 NA NA NA hsa-miR-181b-5p LUZP2 0.488256489401108 0.00105321129419701 1.08272464345489 0.00317141578198537 mirMAP -0.403233217903606 0.000778420166449559 NA NA NA hsa-miR-15a-5p LY6E 0.349521211668244 0.000770735998804736 -3.19057128154329 4.19557506181795e-24 miRNATAP -0.309556839692135 0.0497141333984885 NA NA NA hsa-miR-122-3p LY6H -1.75369011054591 1.52070648599898e-11 2.98068937154464 3.36448745611972e-20 mirMAP -0.41595004164672 7.26284456789746e-12 NA NA NA hsa-miR-194-5p LYN -0.292530160992458 0.0996141384876663 -0.0911270231906292 0.429320299576595 MirTarget -0.119510144214069 0.000143687590328956 NA NA NA hsa-miR-30c-5p LYN -0.432111642767632 0.000159764714931007 -0.0911270231906292 0.429320299576595 MirTarget -0.170531150753635 0.000477425672322227 NA NA NA hsa-miR-30e-5p LYN -0.627815042856657 3.02205690184908e-10 -0.0911270231906292 0.429320299576595 MirTarget -0.240499397390259 1.29988392391577e-05 NA NA NA hsa-miR-222-3p LYNX1 1.08574156066353 1.76407192348131e-11 0.0416489629136718 0.869448587301387 MirTarget -0.154235109448954 0.0391600201476969 NA NA NA hsa-miR-27b-3p LYPD3 -0.823491817819754 9.20935302746823e-14 0.645532255745848 0.00275677959072978 MirTarget;miRNATAP -0.393416274531398 2.17533559619025e-05 NA NA NA hsa-miR-455-3p LYPD3 -1.3998033821095 5.72010709806871e-17 0.645532255745848 0.00275677959072978 MirTarget;PITA;miRNATAP -0.144649233732998 0.017345822167105 NA NA NA hsa-miR-192-5p LYPD6 -0.50188499512787 0.00344713341196035 -0.725999845710353 0.0490901980483611 miRNAWalker2_validate -0.392939703752258 0.00016461291037544 NA NA NA hsa-miR-30c-5p LYPLAL1 -0.432111642767632 0.000159764714931007 0.334284012812255 0.00426402531538069 MirTarget -0.128219535921115 0.0102154609758401 NA NA NA hsa-miR-30e-5p LYPLAL1 -0.627815042856657 3.02205690184908e-10 0.334284012812255 0.00426402531538069 MirTarget -0.166622045102593 0.00322129253077024 NA NA NA hsa-miR-181a-5p LYRM1 0.250113435902954 0.0551933249319293 -0.775358606006421 8.6004568006887e-13 MirTarget -0.267386198222971 6.30907861910371e-11 NA NA NA hsa-miR-181b-5p LYRM1 0.488256489401108 0.00105321129419701 -0.775358606006421 8.6004568006887e-13 MirTarget -0.269478146580459 2.12179173814499e-14 NA NA NA hsa-miR-181a-5p LYRM7 0.250113435902954 0.0551933249319293 -0.285114105890549 0.000746869763807281 mirMAP -0.198339133170779 1.88964968444397e-10 NA NA NA hsa-miR-181b-5p LYRM7 0.488256489401108 0.00105321129419701 -0.285114105890549 0.000746869763807281 mirMAP -0.176985069986944 6.02236498240913e-11 NA NA NA hsa-miR-21-5p LYRM7 1.51084295924322 1.54551622173259e-34 -0.285114105890549 0.000746869763807281 miRNAWalker2_validate -0.246685558442981 1.19117649166692e-16 NA NA NA hsa-miR-29c-3p LYSMD1 -1.4367517608807 1.61767774905781e-21 0.752930498310399 6.73219652186409e-16 MirTarget;miRNATAP -0.166079001094624 1.34545358697478e-08 NA NA NA hsa-miR-181a-5p LYSMD3 0.250113435902954 0.0551933249319293 -0.504034718871008 9.84126014307241e-07 miRNAWalker2_validate;mirMAP -0.267845264899783 1.97581384532636e-12 NA NA NA hsa-miR-181b-5p LYSMD3 0.488256489401108 0.00105321129419701 -0.504034718871008 9.84126014307241e-07 mirMAP -0.243094121263968 1.81814648251232e-13 NA NA NA hsa-miR-21-5p LZTFL1 1.51084295924322 1.54551622173259e-34 -1.00294712153243 8.04932478902966e-12 MirTarget -0.342375510020902 1.99016002722285e-10 NA NA NA hsa-miR-455-3p LZTS1 -1.3998033821095 5.72010709806871e-17 1.15079584218538 1.12530178825836e-10 mirMAP -0.31755667834694 2.59606941316348e-10 NA NA NA hsa-miR-505-5p LZTS1 -0.768282569967001 1.14662846595407e-05 1.15079584218538 1.12530178825836e-10 mirMAP -0.155271315036665 0.0020275368579383 NA NA NA hsa-miR-146b-5p MAB21L2 0.419719546795449 0.0457375823220155 -1.93737687662999 4.90630126371944e-07 miRanda;miRNATAP -0.192890068143846 0.0334375779738019 NA NA NA hsa-miR-19b-3p MAB21L2 0.601279551368824 0.00016685097085251 -1.93737687662999 4.90630126371944e-07 miRNATAP -0.313245140889412 0.00829964908349797 NA NA NA hsa-miR-192-5p MACC1 -0.50188499512787 0.00344713341196035 -2.20994472326424 5.38353974740277e-10 mirMAP -0.658497044265371 7.06012824979267e-11 NA NA NA hsa-miR-20a-5p MACC1 0.854326758727003 5.04256669663285e-07 -2.20994472326424 5.38353974740277e-10 mirMAP -0.603382261775362 2.63903793407364e-09 NA NA NA hsa-miR-192-5p MAD2L1 -0.50188499512787 0.00344713341196035 2.12271197949055 2.5877373631959e-30 miRNAWalker2_validate -0.122583021058259 0.030751139239146 NA NA NA hsa-miR-132-3p MAF 0.323796239695997 0.00272093067935091 -0.855722850331053 1.97147531780957e-13 miRNATAP -0.208525822658678 0.000114996039689702 NA NA NA hsa-miR-19b-3p MAF 0.601279551368824 0.00016685097085251 -0.855722850331053 1.97147531780957e-13 mirMAP -0.100753578910634 0.00561008104147372 NA NA NA hsa-miR-20a-5p MAF 0.854326758727003 5.04256669663285e-07 -0.855722850331053 1.97147531780957e-13 mirMAP -0.122832704018951 0.000280653557683106 NA NA NA hsa-miR-148a-3p MAF1 -0.748702855596996 3.93313343865641e-07 0.587254598885209 1.4790557878107e-07 MirTarget;miRNATAP -0.200491523719441 3.87334746762256e-08 NA NA NA hsa-miR-505-5p MAF1 -0.768282569967001 1.14662846595407e-05 0.587254598885209 1.4790557878107e-07 MirTarget -0.108731285627813 0.000480704996355312 NA NA NA hsa-miR-148a-3p MAFG -0.748702855596996 3.93313343865641e-07 1.20304222370093 2.42633916447559e-19 MirTarget -0.167941692314853 0.000226466679423781 NA NA NA hsa-miR-29c-3p MAFG -1.4367517608807 1.61767774905781e-21 1.20304222370093 2.42633916447559e-19 MirTarget;miRNATAP -0.189830629150413 8.94473702805362e-06 NA NA NA hsa-miR-30c-5p MAFG -0.432111642767632 0.000159764714931007 1.20304222370093 2.42633916447559e-19 mirMAP;miRNATAP -0.136900061514325 0.0218051878911244 NA NA NA hsa-miR-19b-3p MAGI2 0.601279551368824 0.00016685097085251 -0.990214709412416 4.07215252848078e-08 MirTarget;miRNATAP -0.172423228685122 0.00193366442414586 NA NA NA hsa-miR-181a-5p MAGI3 0.250113435902954 0.0551933249319293 -0.591034618812482 1.94730768066587e-06 MirTarget -0.138054553830573 0.00334722462930963 NA NA NA hsa-miR-181b-5p MAGI3 0.488256489401108 0.00105321129419701 -0.591034618812482 1.94730768066587e-06 MirTarget -0.138766709611934 0.000683433116032401 NA NA NA hsa-miR-182-5p MAN1A1 1.96601340710222 4.39326175603633e-09 -1.49548600720255 2.93918068639419e-15 MirTarget -0.105160827848387 0.000159063935552839 NA NA NA hsa-miR-455-5p MAN1A1 -0.270546034117157 0.0581320703577731 -1.49548600720255 2.93918068639419e-15 PITA;miRanda;miRNATAP -0.134650354423492 0.0454580399850164 NA NA NA hsa-miR-146b-5p MAN1A2 0.419719546795449 0.0457375823220155 -0.493930822804955 0.000153700923534437 mirMAP -0.118949164454764 8.51728557191369e-05 NA NA NA hsa-miR-181a-5p MAN1A2 0.250113435902954 0.0551933249319293 -0.493930822804955 0.000153700923534437 mirMAP -0.165055647946669 0.000780479416670882 NA NA NA hsa-miR-181b-5p MAN1A2 0.488256489401108 0.00105321129419701 -0.493930822804955 0.000153700923534437 mirMAP -0.138798480058296 0.0011689394697069 NA NA NA hsa-miR-30b-5p MAN1A2 -0.54056186708617 2.44688760798341e-05 -0.493930822804955 0.000153700923534437 MirTarget -0.163600405828912 0.000979730953603221 NA NA NA hsa-miR-30c-5p MAN1B1 -0.432111642767632 0.000159764714931007 0.360805326287257 1.6993355848775e-05 MirTarget -0.101431802384033 0.00472500196251478 NA NA NA hsa-miR-30e-5p MAN1B1 -0.627815042856657 3.02205690184908e-10 0.360805326287257 1.6993355848775e-05 MirTarget -0.216106593116414 7.77401359213499e-08 NA NA NA hsa-miR-146b-5p MAN1C1 0.419719546795449 0.0457375823220155 -2.43169678885209 2.06495307195248e-21 mirMAP -0.194140974577653 0.0018568629171661 NA NA NA hsa-miR-19b-3p MAN1C1 0.601279551368824 0.00016685097085251 -2.43169678885209 2.06495307195248e-21 MirTarget -0.405207721170644 5.65096506229616e-07 NA NA NA hsa-miR-20a-5p MAN1C1 0.854326758727003 5.04256669663285e-07 -2.43169678885209 2.06495307195248e-21 miRNAWalker2_validate -0.50253332736108 1.66348308508865e-11 NA NA NA hsa-miR-455-5p MAN2A1 -0.270546034117157 0.0581320703577731 -0.552067047617014 0.00197680560071321 miRanda -0.206979930001571 0.000716301187329363 NA NA NA hsa-miR-132-3p MAOA 0.323796239695997 0.00272093067935091 -0.905034495217683 1.14375510544539e-07 MirTarget -0.476274156433901 6.56524521701497e-10 NA NA NA hsa-miR-146b-5p MAOA 0.419719546795449 0.0457375823220155 -0.905034495217683 1.14375510544539e-07 miRanda -0.1308648394412 0.0010914225985134 NA NA NA hsa-miR-194-5p MAP1B -0.292530160992458 0.0996141384876663 0.751522072716614 1.33167615372873e-05 MirTarget -0.444859644054886 1.18350397035332e-22 NA NA NA hsa-miR-19b-3p MAP1B 0.601279551368824 0.00016685097085251 0.751522072716614 1.33167615372873e-05 mirMAP -0.197839772391335 0.00017363238901555 NA NA NA hsa-miR-20a-5p MAP1B 0.854326758727003 5.04256669663285e-07 0.751522072716614 1.33167615372873e-05 mirMAP -0.218717402491076 7.96590919224439e-06 NA NA NA hsa-miR-27b-3p MAP1B -0.823491817819754 9.20935302746823e-14 0.751522072716614 1.33167615372873e-05 miRNATAP -0.194174188305758 0.00969019656533064 NA NA NA hsa-miR-455-3p MAP1B -1.3998033821095 5.72010709806871e-17 0.751522072716614 1.33167615372873e-05 miRNAWalker2_validate -0.316085000949783 3.8806477912246e-11 NA NA NA hsa-miR-455-5p MAP1B -0.270546034117157 0.0581320703577731 0.751522072716614 1.33167615372873e-05 miRanda -0.34528838063363 3.98605158023294e-09 NA NA NA hsa-miR-192-5p MAP1LC3B -0.50188499512787 0.00344713341196035 -0.350337274997815 0.000859321673451714 miRNAWalker2_validate -0.134510341717157 5.65402881349677e-06 NA NA NA hsa-miR-455-5p MAP1LC3B -0.270546034117157 0.0581320703577731 -0.350337274997815 0.000859321673451714 miRanda -0.195258743322806 4.11271339649799e-08 NA NA NA hsa-miR-194-5p MAP2 -0.292530160992458 0.0996141384876663 1.05154488256307 5.66592949255683e-05 MirTarget;miRNATAP -0.162243016611614 0.0251153590981889 NA NA NA hsa-miR-20a-5p MAP2 0.854326758727003 5.04256669663285e-07 1.05154488256307 5.66592949255683e-05 miRNATAP -0.1921213460759 0.0100504096501512 NA NA NA hsa-miR-409-3p MAP2 -0.499649792570937 0.0526751181520117 1.05154488256307 5.66592949255683e-05 MirTarget -0.110886232833149 0.0258519933787469 NA NA NA hsa-miR-34a-5p MAP2K1 1.03694231790865 5.74864019540594e-14 -1.22814648702538 4.27448032410174e-41 miRNAWalker2_validate;miRTarBase -0.229470281840033 1.32655977381036e-11 NA NA NA hsa-miR-15a-5p MAP2K3 0.349521211668244 0.000770735998804736 -1.21754800169498 4.92442767488047e-26 MirTarget;miRNATAP -0.176252893813344 0.00227092078142843 NA NA NA hsa-miR-20a-5p MAP2K3 0.854326758727003 5.04256669663285e-07 -1.21754800169498 4.92442767488047e-26 miRTarBase -0.146114431767222 2.34481412513752e-05 NA NA NA hsa-miR-21-5p MAP2K3 1.51084295924322 1.54551622173259e-34 -1.21754800169498 4.92442767488047e-26 MirTarget -0.296630051548559 1.21863335298365e-11 24112539 The 3'-untranslated region 3'-UTR of MAP2K3 combined with miR-21 was experimentally verified by a miRNA luciferase reporter approach; More importantly the repression of MAP2K3 was inversely correlated with the expression of miR-21 in HCC; Further study demonstrated that the MAP2K3 was a novel direct target of miR-21 which was experimentally validated by a miRNA luciferase reporter approach; In HepG2 cells inhibition of miR-21 expression with an adenoviral miR-21 sponge vector profoundly suppressed cell proliferation by up-regulating MAP2K3 expression at both mRNA and protein levels; These results provide a clinical evidence that MAP2K3 may be a tumor repressor gene and it is a direct target of miR-21 in HCC indicating an underlying mechanism by which miR-21 is able to directly target MAP2K3 and inhibit its expression during the carcinogenesis of HCC at both transcriptional and post-translational levels tumorigenesis liver cancer hsa-miR-34a-5p MAP2K3 1.03694231790865 5.74864019540594e-14 -1.21754800169498 4.92442767488047e-26 miRNATAP -0.115763181314296 0.00601948155472633 NA NA NA hsa-miR-192-5p MAP3K1 -0.50188499512787 0.00344713341196035 0.0159561891588775 0.877325572084852 miRNAWalker2_validate -0.12056340177866 3.22770061138135e-05 NA NA NA hsa-miR-27b-3p MAP3K12 -0.823491817819754 9.20935302746823e-14 0.334893786989642 0.0179755392811318 miRNATAP -0.211348277410436 0.000513662281963951 NA NA NA hsa-miR-30e-5p MAP3K12 -0.627815042856657 3.02205690184908e-10 0.334893786989642 0.0179755392811318 MirTarget -0.26126055014286 0.000126359732055004 NA NA NA hsa-miR-181a-5p MAP3K13 0.250113435902954 0.0551933249319293 -0.448996281023736 0.0575259551730977 mirMAP -0.286787909446984 0.00120999917165148 NA NA NA hsa-miR-181b-5p MAP3K13 0.488256489401108 0.00105321129419701 -0.448996281023736 0.0575259551730977 mirMAP -0.272541117721565 0.00039983088740065 NA NA NA hsa-miR-20a-5p MAP3K13 0.854326758727003 5.04256669663285e-07 -0.448996281023736 0.0575259551730977 miRNATAP -0.184087143328605 0.00601036434848416 NA NA NA hsa-miR-20b-5p MAP3K13 0.457668023910379 0.0285865211936156 -0.448996281023736 0.0575259551730977 miRNATAP -0.186126371506842 0.000705483110765845 NA NA NA hsa-miR-432-5p MAP3K13 -0.536178819038888 0.0748623258271085 -0.448996281023736 0.0575259551730977 MirTarget -0.100713357730632 0.00871923501642769 NA NA NA hsa-miR-17-3p MAP3K14 0.410352776142368 0.00422200500748636 -0.256732855579524 0.0805960527428211 MirTarget -0.134473480210187 0.00705656422421302 NA NA NA hsa-miR-20a-5p MAP3K14 0.854326758727003 5.04256669663285e-07 -0.256732855579524 0.0805960527428211 MirTarget -0.157807215094265 0.000138930673437178 NA NA NA hsa-miR-181a-5p MAP3K2 0.250113435902954 0.0551933249319293 -0.770538748173389 6.13734867546361e-08 mirMAP -0.222650024281137 3.59806321392436e-05 NA NA NA hsa-miR-181b-5p MAP3K2 0.488256489401108 0.00105321129419701 -0.770538748173389 6.13734867546361e-08 mirMAP -0.179966533909382 0.000126100967797753 NA NA NA hsa-miR-19b-3p MAP3K2 0.601279551368824 0.00016685097085251 -0.770538748173389 6.13734867546361e-08 MirTarget;mirMAP;miRNATAP -0.230067258644107 1.09698861161858e-07 NA NA NA hsa-miR-20a-5p MAP3K2 0.854326758727003 5.04256669663285e-07 -0.770538748173389 6.13734867546361e-08 MirTarget;miRNATAP -0.25799642930204 1.23793599245169e-10 NA NA NA hsa-miR-21-5p MAP3K2 1.51084295924322 1.54551622173259e-34 -0.770538748173389 6.13734867546361e-08 miRNAWalker2_validate;mirMAP -0.282876404225472 5.34149880909856e-08 NA NA NA hsa-miR-221-3p MAP3K2 1.12244756358612 3.48370308238012e-13 -0.770538748173389 6.13734867546361e-08 MirTarget -0.239445403358139 4.60022991721426e-08 NA NA NA hsa-miR-222-3p MAP3K2 1.08574156066353 1.76407192348131e-11 -0.770538748173389 6.13734867546361e-08 MirTarget -0.190649654673579 6.47923726771857e-06 NA NA NA hsa-miR-30b-5p MAP3K2 -0.54056186708617 2.44688760798341e-05 -0.770538748173389 6.13734867546361e-08 mirMAP;miRNATAP -0.150237123045351 0.00605408298920415 NA NA NA hsa-miR-455-5p MAP3K2 -0.270546034117157 0.0581320703577731 -0.770538748173389 6.13734867546361e-08 miRNATAP -0.242113129076012 7.56196724527458e-07 NA NA NA hsa-miR-146b-5p MAP3K5 0.419719546795449 0.0457375823220155 -1.33601122467136 1.03028348684945e-07 miRanda -0.319441648919432 4.29798576572251e-08 NA NA NA hsa-miR-20a-5p MAP3K5 0.854326758727003 5.04256669663285e-07 -1.33601122467136 1.03028348684945e-07 miRNATAP -0.349691468275886 1.01213992658686e-06 NA NA NA hsa-miR-20a-5p MAP3K8 0.854326758727003 5.04256669663285e-07 -0.159965748968671 0.44777579319131 MirTarget;miRNATAP -0.117316128957401 0.049568903288141 NA NA NA hsa-miR-181a-5p MAP3K9 0.250113435902954 0.0551933249319293 0.681574787109281 3.69974619451209e-07 mirMAP -0.194912020161265 0.000121629006102773 NA NA NA hsa-miR-181b-5p MAP3K9 0.488256489401108 0.00105321129419701 0.681574787109281 3.69974619451209e-07 mirMAP -0.11289028667318 0.0108959392866681 NA NA NA hsa-miR-17-3p MAP4 0.410352776142368 0.00422200500748636 0.399832636864958 1.14509582949846e-08 MirTarget;miRNATAP -0.109215218197495 4.81268009293353e-06 NA NA NA hsa-miR-29c-3p MAP4K4 -1.4367517608807 1.61767774905781e-21 0.521517663752677 1.06487649030441e-08 miRNATAP -0.199275181647567 6.56755058404354e-13 NA NA NA hsa-miR-15a-5p MAP7 0.349521211668244 0.000770735998804736 -1.05909886037011 4.31384656448488e-08 MirTarget;miRNATAP -0.371732777856019 5.39561551133019e-05 NA NA NA hsa-miR-19b-3p MAP7 0.601279551368824 0.00016685097085251 -1.05909886037011 4.31384656448488e-08 miRNAWalker2_validate -0.208946350412469 0.000445606833544659 NA NA NA hsa-miR-20a-5p MAP7 0.854326758727003 5.04256669663285e-07 -1.05909886037011 4.31384656448488e-08 miRNATAP -0.25568560830628 3.61392749909034e-06 NA NA NA hsa-miR-20b-5p MAP7 0.457668023910379 0.0285865211936156 -1.05909886037011 4.31384656448488e-08 miRNATAP -0.167379472758477 0.000240565628194529 NA NA NA hsa-miR-148a-3p MAP7D2 -0.748702855596996 3.93313343865641e-07 0.763166018662374 0.0866664092768403 MirTarget -0.466762788951956 0.00132535874257167 NA NA NA hsa-miR-20a-5p MAP9 0.854326758727003 5.04256669663285e-07 -1.37818477884312 4.1786518609997e-07 miRNATAP -0.35926355321719 3.63734604244686e-06 NA NA NA hsa-miR-146b-5p MAPK10 0.419719546795449 0.0457375823220155 -1.09210524801043 3.20431274629696e-05 miRanda -0.252372073662625 3.58793936262133e-05 NA NA NA hsa-miR-19b-3p MAPK10 0.601279551368824 0.00016685097085251 -1.09210524801043 3.20431274629696e-05 miRNATAP -0.202245351611927 0.0120351860236733 NA NA NA hsa-miR-221-3p MAPK10 1.12244756358612 3.48370308238012e-13 -1.09210524801043 3.20431274629696e-05 miRNATAP -0.345546531666561 1.95748420882985e-05 NA NA NA hsa-miR-222-3p MAPK10 1.08574156066353 1.76407192348131e-11 -1.09210524801043 3.20431274629696e-05 miRNATAP -0.215253828844877 0.00588066987412212 NA NA NA hsa-miR-455-5p MAPK10 -0.270546034117157 0.0581320703577731 -1.09210524801043 3.20431274629696e-05 miRanda -0.235174401855498 0.00956735979323835 NA NA NA hsa-miR-27b-3p MAPK7 -0.823491817819754 9.20935302746823e-14 0.305136164161477 0.000440978428375878 miRNATAP -0.123415319315889 0.000963752517439649 NA NA NA hsa-miR-30b-5p MAPK8 -0.54056186708617 2.44688760798341e-05 -0.855423391564126 4.38860774117184e-05 mirMAP -0.211224878227047 0.0083058660521866 NA NA NA hsa-miR-27b-3p MAPK8IP3 -0.823491817819754 9.20935302746823e-14 1.01234491290533 3.03085078878221e-14 miRNATAP -0.159381047264504 0.00713313993309301 NA NA NA hsa-miR-29c-3p MAPKBP1 -1.4367517608807 1.61767774905781e-21 0.70444398177884 4.76261581875458e-17 MirTarget -0.138150841276816 1.77075103447967e-07 NA NA NA hsa-miR-29c-3p MAPRE1 -1.4367517608807 1.61767774905781e-21 0.332650746770886 0.000501958694685901 MirTarget -0.239534935095754 3.31621855775642e-17 NA NA NA hsa-miR-20a-5p MAPRE2 0.854326758727003 5.04256669663285e-07 -0.72153637646019 1.20155521437307e-08 mirMAP -0.234453366692199 5.01188103722971e-11 NA NA NA hsa-miR-19b-3p MAPRE3 0.601279551368824 0.00016685097085251 -0.343621594450327 0.00477525960848748 miRNAWalker2_validate -0.219054657147623 1.78678583997082e-09 NA NA NA hsa-miR-20a-5p MAPRE3 0.854326758727003 5.04256669663285e-07 -0.343621594450327 0.00477525960848748 MirTarget;miRNATAP -0.256639529832754 1.88980795269617e-14 NA NA NA hsa-miR-20b-5p MAPRE3 0.457668023910379 0.0285865211936156 -0.343621594450327 0.00477525960848748 MirTarget;miRNATAP -0.104310463672921 0.00022660786771975 NA NA NA hsa-miR-214-5p MAPT -1.91497809567701 3.92955595018147e-12 2.58490052544186 2.18799071553378e-25 MirTarget -0.134299912062498 0.00349347879837339 NA NA NA hsa-miR-27b-3p MAPT -0.823491817819754 9.20935302746823e-14 2.58490052544186 2.18799071553378e-25 miRNATAP -0.53917741089395 1.73408872285656e-06 NA NA NA hsa-miR-505-5p MAPT -0.768282569967001 1.14662846595407e-05 2.58490052544186 2.18799071553378e-25 MirTarget -0.381437731747387 1.17393222103414e-07 NA NA NA hsa-miR-148a-3p MARCH3 -0.748702855596996 3.93313343865641e-07 0.616348863709913 0.0025556726558054 MirTarget;miRNATAP -0.624353117326105 9.30331919035579e-23 NA NA NA hsa-miR-192-5p MARCH3 -0.50188499512787 0.00344713341196035 0.616348863709913 0.0025556726558054 mirMAP -0.295123164251184 2.82948293495367e-07 NA NA NA hsa-miR-30e-5p MARCH3 -0.627815042856657 3.02205690184908e-10 0.616348863709913 0.0025556726558054 mirMAP -0.461947436535415 2.57796465979948e-06 NA NA NA hsa-miR-181a-5p MARCH6 0.250113435902954 0.0551933249319293 0.136690343626456 0.204152843148062 MirTarget -0.124999052604996 0.00188292303975389 NA NA NA hsa-miR-19b-3p MARCH8 0.601279551368824 0.00016685097085251 -0.373395342611516 0.0861484318288631 mirMAP -0.228630513119174 0.000523596777644733 NA NA NA hsa-miR-20a-5p MARCH8 0.854326758727003 5.04256669663285e-07 -0.373395342611516 0.0861484318288631 MirTarget;miRNATAP -0.266166660232652 1.37890600926122e-05 NA NA NA hsa-miR-192-3p MARCKS -0.6401165114007 0.000266272092403814 0.47891030020215 0.00159784808861844 MirTarget -0.294288353300008 6.83192090199099e-13 NA NA NA hsa-miR-27b-3p MARCKS -0.823491817819754 9.20935302746823e-14 0.47891030020215 0.00159784808861844 MirTarget -0.223293023884137 0.000643271291176012 NA NA NA hsa-miR-34a-5p MARCKS 1.03694231790865 5.74864019540594e-14 0.47891030020215 0.00159784808861844 MirTarget -0.143974944525062 0.00589873065252314 NA NA NA hsa-miR-34a-5p MARCKSL1 1.03694231790865 5.74864019540594e-14 0.308949751259346 0.0647399541617895 MirTarget;miRNATAP -0.137514074533044 0.016777184940542 NA NA NA hsa-miR-30e-5p MARK1 -0.627815042856657 3.02205690184908e-10 0.0714268590059156 0.762956488431703 mirMAP -0.385154681792473 0.000730385783980133 NA NA NA hsa-miR-29c-3p MARK2 -1.4367517608807 1.61767774905781e-21 0.295221812881808 0.000110382690471215 mirMAP -0.127185789876622 4.3328600648974e-08 NA NA NA hsa-miR-15a-5p MASP1 0.349521211668244 0.000770735998804736 -2.15158700520982 9.54273004956584e-22 MirTarget -0.263836677365156 0.0180550121840676 NA NA NA hsa-miR-20a-5p MAT2B 0.854326758727003 5.04256669663285e-07 -0.273105814463069 0.00263130083756265 MirTarget;miRNATAP -0.130845195810981 2.67912570648619e-07 NA NA NA hsa-miR-21-5p MATN2 1.51084295924322 1.54551622173259e-34 -0.692218006755673 0.0026937518103409 miRNATAP -0.439006230822363 1.45013185590069e-07 NA NA NA hsa-miR-148a-3p MATN3 -0.748702855596996 3.93313343865641e-07 2.24574154450948 1.20068691324261e-08 MirTarget -0.571507102978337 1.13120648716878e-05 NA NA NA hsa-miR-27b-3p MATN3 -0.823491817819754 9.20935302746823e-14 2.24574154450948 1.20068691324261e-08 MirTarget;miRNATAP -0.87816733952884 2.77796099819256e-07 NA NA NA hsa-miR-29c-3p MAZ -1.4367517608807 1.61767774905781e-21 0.857666124638355 9.29488846188585e-23 miRNATAP -0.225733515017237 1.3233569132395e-16 NA NA NA hsa-miR-146b-5p MBD5 0.419719546795449 0.0457375823220155 0.0812181526143048 0.482792962394029 miRanda -0.109187949696919 4.00777759689317e-05 NA NA NA hsa-miR-182-5p MBLAC2 1.96601340710222 4.39326175603633e-09 -0.651946233751667 4.55219397233215e-07 MirTarget -0.100721303643839 4.35861904791487e-08 NA NA NA hsa-miR-21-5p MBLAC2 1.51084295924322 1.54551622173259e-34 -0.651946233751667 4.55219397233215e-07 MirTarget -0.420975094961421 2.6165956891375e-20 NA NA NA hsa-miR-15a-5p MBNL2 0.349521211668244 0.000770735998804736 -1.32208886120192 1.96175870553543e-18 MirTarget -0.289434703810661 8.89557419398001e-05 NA NA NA hsa-miR-181a-5p MBNL2 0.250113435902954 0.0551933249319293 -1.32208886120192 1.96175870553543e-18 MirTarget;miRNATAP -0.225253054381771 0.000129795479925439 NA NA NA hsa-miR-181b-5p MBNL2 0.488256489401108 0.00105321129419701 -1.32208886120192 1.96175870553543e-18 MirTarget;miRNATAP -0.232666303233361 5.09560915535265e-06 NA NA NA hsa-miR-182-5p MBNL2 1.96601340710222 4.39326175603633e-09 -1.32208886120192 1.96175870553543e-18 MirTarget;miRNATAP -0.104901107763857 2.42757177003634e-06 NA NA NA hsa-miR-19b-3p MBNL2 0.601279551368824 0.00016685097085251 -1.32208886120192 1.96175870553543e-18 miRNATAP -0.213921162806546 6.62961287529011e-06 NA NA NA hsa-miR-132-3p MBNL3 0.323796239695997 0.00272093067935091 -0.597245834128655 0.0142379871483953 mirMAP -0.356184148512709 0.00126961032218325 NA NA NA hsa-miR-181a-5p MBNL3 0.250113435902954 0.0551933249319293 -0.597245834128655 0.0142379871483953 mirMAP -0.199749178256047 0.0295221048906677 NA NA NA hsa-miR-181b-5p MBNL3 0.488256489401108 0.00105321129419701 -0.597245834128655 0.0142379871483953 mirMAP -0.217365679302565 0.00638945619654699 NA NA NA hsa-miR-21-5p MBNL3 1.51084295924322 1.54551622173259e-34 -0.597245834128655 0.0142379871483953 MirTarget;mirMAP -0.4533266262411 2.65298361951513e-07 NA NA NA hsa-miR-30b-5p MBNL3 -0.54056186708617 2.44688760798341e-05 -0.597245834128655 0.0142379871483953 MirTarget;mirMAP -0.342438938431876 0.000203690934228326 NA NA NA hsa-miR-148a-3p MBP -0.748702855596996 3.93313343865641e-07 -0.401034568218827 0.00152582531127159 mirMAP -0.101868769145895 0.0140733136781751 NA NA NA hsa-miR-19b-3p MBP 0.601279551368824 0.00016685097085251 -0.401034568218827 0.00152582531127159 mirMAP -0.100728189898724 0.00898259609518544 NA NA NA hsa-miR-21-5p MBP 1.51084295924322 1.54551622173259e-34 -0.401034568218827 0.00152582531127159 mirMAP -0.141180976134 0.00226478841976692 NA NA NA hsa-miR-20a-5p MBTPS1 0.854326758727003 5.04256669663285e-07 -0.204180275737213 0.00573895216061998 miRNATAP -0.117277483246402 1.17772683008292e-08 NA NA NA hsa-miR-21-5p MBTPS2 1.51084295924322 1.54551622173259e-34 -0.319653122535307 0.000361871015724243 miRNATAP -0.201114962301786 4.01285459715525e-10 NA NA NA hsa-miR-192-5p MCAM -0.50188499512787 0.00344713341196035 1.33945352136389 1.93175099944524e-20 miRNAWalker2_validate -0.407079648231632 1.54803944429173e-23 NA NA NA hsa-miR-215-5p MCAM -0.981544773246509 3.14452272477156e-05 1.33945352136389 1.93175099944524e-20 miRNAWalker2_validate -0.119242497186045 0.00011484146496496 NA NA NA hsa-miR-146b-5p MCC 0.419719546795449 0.0457375823220155 -2.36915505634884 5.46995786737825e-22 miRanda -0.175677638449804 0.00343256163100709 NA NA NA hsa-miR-181b-5p MCC 0.488256489401108 0.00105321129419701 -2.36915505634884 5.46995786737825e-22 MirTarget -0.186852753088202 0.0274464436745467 NA NA NA hsa-miR-20a-5p MCC 0.854326758727003 5.04256669663285e-07 -2.36915505634884 5.46995786737825e-22 MirTarget -0.271809542484128 0.000202316721973451 NA NA NA hsa-miR-21-5p MCC 1.51084295924322 1.54551622173259e-34 -2.36915505634884 5.46995786737825e-22 mirMAP -0.582634900768505 3.39690430566654e-10 NA NA NA hsa-miR-224-3p MCC 1.40770116795301 1.31426607144612e-08 -2.36915505634884 5.46995786737825e-22 mirMAP -0.131373543417198 0.00966019406779107 NA NA NA hsa-miR-132-3p MCFD2 0.323796239695997 0.00272093067935091 -0.251093559120312 0.00682863731205307 mirMAP -0.242067896644295 4.96438211264536e-09 NA NA NA hsa-miR-30b-5p MCFD2 -0.54056186708617 2.44688760798341e-05 -0.251093559120312 0.00682863731205307 miRNAWalker2_validate -0.172989152685222 6.6234086793477e-07 NA NA NA hsa-miR-15a-5p MCL1 0.349521211668244 0.000770735998804736 -1.08478249996404 1.88833352070372e-27 miRNAWalker2_validate -0.144477692829072 0.00399514264598915 NA NA NA hsa-miR-20a-5p MCL1 0.854326758727003 5.04256669663285e-07 -1.08478249996404 1.88833352070372e-27 MirTarget;miRNATAP -0.114471714846913 0.000140895848956066 23594563 Subsequent investigations revealed that miR-20a directly targeted myeloid cell leukemia sequence 1 Mcl-1 and reduced the endogenous protein level of Mcl-1 in HCC cells liver cancer hsa-miR-192-5p MCM10 -0.50188499512787 0.00344713341196035 3.44644537200841 1.46743341445993e-36 miRNAWalker2_validate -0.205997953722998 0.0151367215753814 NA NA NA hsa-miR-215-5p MCM10 -0.981544773246509 3.14452272477156e-05 3.44644537200841 1.46743341445993e-36 miRNAWalker2_validate -0.15731858222731 0.0101978997891122 NA NA NA hsa-miR-192-5p MCM3 -0.50188499512787 0.00344713341196035 1.38245898490982 6.59458276841991e-26 miRNAWalker2_validate -0.118151752469436 0.00283190558585697 NA NA NA hsa-miR-192-5p MCM6 -0.50188499512787 0.00344713341196035 1.68713872113643 5.47744551594301e-30 miRNAWalker2_validate -0.129535871289776 0.00415957553139546 NA NA NA hsa-miR-99a-5p MCM8 -1.51481656384839 3.93230057259529e-14 1.26713752120723 4.49769252025548e-15 miRNAWalker2_validate -0.216656612997587 2.48024203127108e-08 NA NA NA hsa-miR-146b-5p MCTP2 0.419719546795449 0.0457375823220155 -1.15678038284127 0.000687454226895558 MirTarget;miRanda -0.251471848436108 0.0015228299606568 NA NA NA hsa-miR-455-5p MCTP2 -0.270546034117157 0.0581320703577731 -1.15678038284127 0.000687454226895558 miRanda -0.561853312404359 1.33952377170012e-06 NA NA NA hsa-miR-19b-3p MDFIC 0.601279551368824 0.00016685097085251 -0.770786921792818 0.000159033069942859 MirTarget;miRNATAP -0.376532580691061 8.12929415210692e-10 NA NA NA hsa-miR-27b-3p MDGA1 -0.823491817819754 9.20935302746823e-14 1.09023577522186 0.00025808585973707 mirMAP -0.419485130139583 0.00116288148560143 NA NA NA hsa-miR-455-3p MDGA1 -1.3998033821095 5.72010709806871e-17 1.09023577522186 0.00025808585973707 mirMAP -0.260935630337113 0.0019347536638436 NA NA NA hsa-miR-455-5p MDGA1 -0.270546034117157 0.0581320703577731 1.09023577522186 0.00025808585973707 mirMAP -0.36420616063128 0.00038161798444254 NA NA NA hsa-miR-214-5p MDGA2 -1.91497809567701 3.92955595018147e-12 0.095338851975197 0.824518766363714 miRNATAP -0.207767863401804 0.00548431854717244 NA NA NA hsa-miR-27b-3p MDH2 -0.823491817819754 9.20935302746823e-14 0.0705623377515829 0.50753860917769 miRNAWalker2_validate -0.104734148077956 0.0220775013193601 NA NA NA hsa-miR-30e-5p MDM4 -0.627815042856657 3.02205690184908e-10 0.73357660128009 1.75853291398166e-12 mirMAP -0.103460747571472 0.0452314704413228 NA NA NA hsa-miR-222-3p MDN1 1.08574156066353 1.76407192348131e-11 -0.913913212145325 3.68643910191393e-06 miRNAWalker2_validate -0.147424699226069 0.0123545839486091 NA NA NA hsa-miR-19b-3p MECOM 0.601279551368824 0.00016685097085251 0.959512171082984 9.09579943703071e-08 miRNATAP -0.129331453668629 0.0196315279663432 NA NA NA hsa-miR-455-5p MECOM -0.270546034117157 0.0581320703577731 0.959512171082984 9.09579943703071e-08 miRanda -0.34626889403173 1.80675931190258e-08 NA NA NA hsa-miR-148a-3p MECP2 -0.748702855596996 3.93313343865641e-07 0.263893569030019 0.000429500323071978 miRNATAP -0.107629546729185 9.50479455092943e-06 NA NA NA hsa-miR-192-5p MECP2 -0.50188499512787 0.00344713341196035 0.263893569030019 0.000429500323071978 mirMAP;miRNATAP -0.130299154032966 4.0946454337433e-10 NA NA NA hsa-miR-194-5p MECP2 -0.292530160992458 0.0996141384876663 0.263893569030019 0.000429500323071978 mirMAP;miRNATAP -0.124314918081839 7.78472356420858e-10 NA NA NA hsa-miR-15a-5p MED13 0.349521211668244 0.000770735998804736 -0.257825410256131 0.00586345422218079 miRNATAP -0.131770534165073 0.00275509689110432 NA NA NA hsa-miR-122-3p MED22 -1.75369011054591 1.52070648599898e-11 0.901475361439055 2.19971977737607e-20 mirMAP -0.172819655431128 1.71847296154468e-22 NA NA NA hsa-miR-192-3p MED22 -0.6401165114007 0.000266272092403814 0.901475361439055 2.19971977737607e-20 mirMAP -0.178311585371081 1.05554143600926e-10 NA NA NA hsa-miR-192-5p MED22 -0.50188499512787 0.00344713341196035 0.901475361439055 2.19971977737607e-20 miRNAWalker2_validate;mirMAP -0.169635883856321 2.43222104424426e-09 NA NA NA hsa-miR-215-5p MED22 -0.981544773246509 3.14452272477156e-05 0.901475361439055 2.19971977737607e-20 miRNAWalker2_validate -0.103350159861403 5.73185729238249e-07 NA NA NA hsa-miR-132-3p MED9 0.323796239695997 0.00272093067935091 -0.159669590141547 0.0955422333529577 MirTarget -0.151030117380659 0.000467802144242198 NA NA NA hsa-miR-132-3p MEF2A 0.323796239695997 0.00272093067935091 -0.4924154435107 8.54172101119762e-06 miRNAWalker2_validate -0.101122589272738 0.0459547101659198 NA NA NA hsa-miR-21-5p MEF2A 1.51084295924322 1.54551622173259e-34 -0.4924154435107 8.54172101119762e-06 miRNAWalker2_validate -0.209572178655664 1.86913254606396e-07 NA NA NA hsa-miR-455-5p MEF2A -0.270546034117157 0.0581320703577731 -0.4924154435107 8.54172101119762e-06 miRanda -0.127989089546929 0.000779199650163116 NA NA NA hsa-miR-194-5p MEF2C -0.292530160992458 0.0996141384876663 0.0778716667649269 0.518249252095398 miRNATAP -0.200113971660217 6.62610057126619e-10 NA NA NA hsa-miR-19b-3p MEF2C 0.601279551368824 0.00016685097085251 0.0778716667649269 0.518249252095398 miRNATAP -0.125599767113762 0.000559225556173317 NA NA NA hsa-miR-30c-5p MEF2D -0.432111642767632 0.000159764714931007 0.55349304057489 3.92683185651606e-10 mirMAP -0.135586125400984 0.000392227001939828 NA NA NA hsa-miR-30e-5p MEF2D -0.627815042856657 3.02205690184908e-10 0.55349304057489 3.92683185651606e-10 mirMAP -0.10718457161929 0.0138608435149686 NA NA NA hsa-miR-455-3p MEGF6 -1.3998033821095 5.72010709806871e-17 -0.450114201763533 0.123474613222427 MirTarget -0.236117255474175 0.00396686151071532 NA NA NA hsa-miR-181a-5p MEGF9 0.250113435902954 0.0551933249319293 -0.767121149729698 4.19664132638782e-10 MirTarget -0.186903528248944 6.44320487076665e-05 NA NA NA hsa-miR-181b-5p MEGF9 0.488256489401108 0.00105321129419701 -0.767121149729698 4.19664132638782e-10 MirTarget -0.186817572281339 4.10481932153354e-06 NA NA NA hsa-miR-21-5p MEGF9 1.51084295924322 1.54551622173259e-34 -0.767121149729698 4.19664132638782e-10 miRNAWalker2_validate;mirMAP;miRNATAP -0.33278690568075 6.687300960684e-14 NA NA NA hsa-miR-221-3p MEGF9 1.12244756358612 3.48370308238012e-13 -0.767121149729698 4.19664132638782e-10 MirTarget;miRNATAP -0.153028854885442 6.49570820433605e-05 NA NA NA hsa-miR-222-3p MEGF9 1.08574156066353 1.76407192348131e-11 -0.767121149729698 4.19664132638782e-10 MirTarget;miRNATAP -0.172535611152183 2.47029814648977e-06 NA NA NA hsa-miR-192-5p MEIS2 -0.50188499512787 0.00344713341196035 0.156457406703811 0.32841086989024 miRNAWalker2_validate -0.251184999337731 1.85224113713703e-08 NA NA NA hsa-miR-194-5p MEIS2 -0.292530160992458 0.0996141384876663 0.156457406703811 0.32841086989024 MirTarget;miRNATAP -0.219199989965156 4.48170941860142e-07 NA NA NA hsa-miR-27b-3p MEIS2 -0.823491817819754 9.20935302746823e-14 0.156457406703811 0.32841086989024 MirTarget;miRNATAP -0.201420413922627 0.00341615257701412 NA NA NA hsa-miR-30e-5p MEIS2 -0.627815042856657 3.02205690184908e-10 0.156457406703811 0.32841086989024 MirTarget -0.20574840240558 0.00773804468678315 NA NA NA hsa-miR-455-3p MEOX1 -1.3998033821095 5.72010709806871e-17 0.957298126718039 0.00329715647493116 miRNATAP -0.450189559380739 7.19833137618722e-07 NA NA NA hsa-miR-30c-5p MEOX2 -0.432111642767632 0.000159764714931007 1.3378919040585 2.13602029063847e-06 miRNATAP -0.268316577932969 0.0277178072371461 NA NA NA hsa-miR-132-3p MEPCE 0.323796239695997 0.00272093067935091 0.255283721593848 0.00176043051414384 miRNATAP -0.11778885570564 0.0014227357351829 NA NA NA hsa-miR-181b-5p MEPCE 0.488256489401108 0.00105321129419701 0.255283721593848 0.00176043051414384 miRNAWalker2_validate -0.132053343405733 5.38159780833237e-07 NA NA NA hsa-miR-29c-3p MEST -1.4367517608807 1.61767774905781e-21 -0.745223908511012 6.12641025738862e-06 MirTarget;miRNATAP -0.262535551165514 2.16073906123927e-07 NA NA NA hsa-miR-30b-5p METTL2B -0.54056186708617 2.44688760798341e-05 0.29920735075176 0.00010097847583241 mirMAP -0.144377529486716 5.95676404625678e-07 NA NA NA hsa-miR-20b-5p METTL7A 0.457668023910379 0.0285865211936156 -1.15038870624553 1.17460294487533e-12 mirMAP -0.137745669572901 0.000361149730970424 NA NA NA hsa-miR-192-5p METTL9 -0.50188499512787 0.00344713341196035 0.228543330129342 0.0119977624175472 miRNAWalker2_validate -0.221384327901342 2.76868031081088e-19 NA NA NA hsa-miR-192-3p MEX3B -0.6401165114007 0.000266272092403814 0.521497613312576 0.00979968275068838 mirMAP -0.382612697724552 2.26966130616186e-12 NA NA NA hsa-miR-192-5p MEX3B -0.50188499512787 0.00344713341196035 0.521497613312576 0.00979968275068838 miRNAWalker2_validate -0.413107534163523 1.29160027577422e-13 NA NA NA hsa-miR-215-5p MEX3B -0.981544773246509 3.14452272477156e-05 0.521497613312576 0.00979968275068838 miRNAWalker2_validate -0.103686209660829 0.0124049588144798 NA NA NA hsa-miR-455-3p MEX3B -1.3998033821095 5.72010709806871e-17 0.521497613312576 0.00979968275068838 miRNATAP -0.201416611434742 0.00037318664241772 NA NA NA hsa-miR-34a-5p MEX3C 1.03694231790865 5.74864019540594e-14 -0.106102831368297 0.302202681688335 MirTarget -0.179967285911572 2.29617898538876e-07 NA NA NA hsa-miR-29c-3p MFAP2 -1.4367517608807 1.61767774905781e-21 0.623279740175152 0.116457718316371 miRNATAP -0.678894561745588 1.75007597338861e-08 NA NA NA hsa-miR-181a-5p MFAP3L 0.250113435902954 0.0551933249319293 -2.99511248620354 4.97173912475439e-19 mirMAP;miRNATAP -0.924638257899851 6.37087455540834e-13 NA NA NA hsa-miR-181b-5p MFAP3L 0.488256489401108 0.00105321129419701 -2.99511248620354 4.97173912475439e-19 mirMAP;miRNATAP -1.03781549854935 2.30763502509261e-21 NA NA NA hsa-miR-182-5p MFAP3L 1.96601340710222 4.39326175603633e-09 -2.99511248620354 4.97173912475439e-19 miRNATAP -0.258059620347335 1.89366917601675e-07 NA NA NA hsa-miR-20a-5p MFAP3L 0.854326758727003 5.04256669663285e-07 -2.99511248620354 4.97173912475439e-19 MirTarget;miRNATAP -0.827194212004749 5.69897325485743e-18 NA NA NA hsa-miR-455-5p MFAP3L -0.270546034117157 0.0581320703577731 -2.99511248620354 4.97173912475439e-19 PITA;miRanda;miRNATAP -0.239205048160411 0.0474445946826924 NA NA NA hsa-miR-455-5p MFGE8 -0.270546034117157 0.0581320703577731 0.980930670797802 1.45880246249867e-09 miRanda -0.227031691414597 5.54934033822295e-05 NA NA NA hsa-miR-30b-5p MFHAS1 -0.54056186708617 2.44688760798341e-05 -0.266888053937675 0.214504037764653 mirMAP -0.194445942993153 0.0170640861665427 NA NA NA hsa-miR-455-5p MFHAS1 -0.270546034117157 0.0581320703577731 -0.266888053937675 0.214504037764653 miRNATAP -0.165014072991525 0.0250953751250078 NA NA NA hsa-miR-17-3p MFN2 0.410352776142368 0.00422200500748636 -0.60468815586085 4.04345111138286e-11 MirTarget -0.104472626763744 0.000988092227106997 NA NA NA hsa-miR-20a-5p MFN2 0.854326758727003 5.04256669663285e-07 -0.60468815586085 4.04345111138286e-11 MirTarget -0.140131360767352 8.41876408813981e-08 NA NA NA hsa-miR-221-3p MFN2 1.12244756358612 3.48370308238012e-13 -0.60468815586085 4.04345111138286e-11 miRNAWalker2_validate -0.207769422705299 1.03150022618557e-13 NA NA NA hsa-miR-192-5p MFSD10 -0.50188499512787 0.00344713341196035 0.829274707400239 3.50865672604536e-08 miRNAWalker2_validate -0.435263868555597 9.92627944751977e-27 NA NA NA hsa-miR-146b-5p MFSD2A 0.419719546795449 0.0457375823220155 -4.65733198145912 1.51611385182154e-20 miRanda -0.380061162690273 0.00182823410479347 NA NA NA hsa-miR-181b-5p MFSD8 0.488256489401108 0.00105321129419701 -0.3605492062265 6.85176011402975e-06 MirTarget -0.100217071712647 0.000130375364338969 NA NA NA hsa-miR-148a-3p MGAT4A -0.748702855596996 3.93313343865641e-07 0.104155687943847 0.347191347682603 MirTarget;miRNATAP -0.189467335208124 1.05295218983964e-07 NA NA NA hsa-miR-15a-5p MGAT4A 0.349521211668244 0.000770735998804736 0.104155687943847 0.347191347682603 MirTarget;miRNATAP -0.103890343023336 0.0462541296215408 NA NA NA hsa-miR-194-5p MGAT4A -0.292530160992458 0.0996141384876663 0.104155687943847 0.347191347682603 miRNATAP -0.104428000381343 0.000556568319906284 NA NA NA hsa-miR-34a-5p MGAT4A 1.03694231790865 5.74864019540594e-14 0.104155687943847 0.347191347682603 MirTarget;miRNATAP -0.182990618167464 1.10439245640158e-06 NA NA NA hsa-miR-146b-5p MGAT5 0.419719546795449 0.0457375823220155 -0.048940912253241 0.86560089431757 mirMAP -0.1983624049014 0.00302188291429085 NA NA NA hsa-miR-15a-5p MGAT5 0.349521211668244 0.000770735998804736 -0.048940912253241 0.86560089431757 mirMAP -0.371706832133778 0.00628924762727632 NA NA NA hsa-miR-20a-5p MGAT5 0.854326758727003 5.04256669663285e-07 -0.048940912253241 0.86560089431757 mirMAP -0.323078633968526 7.22811007213867e-05 NA NA NA hsa-miR-652-3p MGST1 0.135945800164278 0.391695970197646 -1.25381905797549 6.6563285633603e-08 miRNAWalker2_validate -0.244114267698205 0.00076212917849627 NA NA NA hsa-miR-132-3p MIA3 0.323796239695997 0.00272093067935091 -0.209214323545272 0.0718582390655248 MirTarget;miRNATAP -0.353078174352228 6.3744009754727e-12 NA NA NA hsa-miR-222-3p MIA3 1.08574156066353 1.76407192348131e-11 -0.209214323545272 0.0718582390655248 MirTarget;miRNATAP -0.130604290282109 0.000126806074019864 NA NA NA hsa-miR-30b-5p MIA3 -0.54056186708617 2.44688760798341e-05 -0.209214323545272 0.0718582390655248 MirTarget -0.201995505523356 3.62784687815149e-06 NA NA NA hsa-miR-21-5p MIB1 1.51084295924322 1.54551622173259e-34 -0.0264398771590288 0.808071482948044 miRNAWalker2_validate;mirMAP -0.125529680447218 0.00148022035997289 NA NA NA hsa-miR-30b-5p MIB1 -0.54056186708617 2.44688760798341e-05 -0.0264398771590288 0.808071482948044 MirTarget;mirMAP -0.130904604564369 0.00141745487429936 NA NA NA hsa-miR-30c-5p MICAL1 -0.432111642767632 0.000159764714931007 1.01227467063933 4.1069938923571e-08 MirTarget;miRNATAP -0.156891422856294 0.0499879112183034 NA NA NA hsa-miR-30e-5p MICAL1 -0.627815042856657 3.02205690184908e-10 1.01227467063933 4.1069938923571e-08 MirTarget -0.684597657932489 6.29273401618938e-15 NA NA NA hsa-miR-19b-3p MICAL2 0.601279551368824 0.00016685097085251 0.116541536928325 0.419459906483774 MirTarget -0.222485036341812 2.69330299260947e-07 NA NA NA hsa-miR-19b-3p MIER1 0.601279551368824 0.00016685097085251 -0.824909145213854 1.42440055744365e-21 MirTarget;miRNATAP -0.145908654651914 8.19035112832246e-08 NA NA NA hsa-miR-455-5p MIER1 -0.270546034117157 0.0581320703577731 -0.824909145213854 1.42440055744365e-21 MirTarget;miRanda -0.13450208711358 1.29817613864272e-05 NA NA NA hsa-miR-17-3p MIER3 0.410352776142368 0.00422200500748636 -0.289689451855984 0.00044472169352925 MirTarget;miRNATAP -0.11542961642123 3.52666724597996e-05 NA NA NA hsa-miR-181a-5p MIER3 0.250113435902954 0.0551933249319293 -0.289689451855984 0.00044472169352925 MirTarget;miRNATAP -0.15755661966597 2.70933222466173e-07 NA NA NA hsa-miR-181b-5p MIER3 0.488256489401108 0.00105321129419701 -0.289689451855984 0.00044472169352925 MirTarget;miRNATAP -0.169730173681719 1.3195551531538e-10 NA NA NA hsa-miR-221-3p MIER3 1.12244756358612 3.48370308238012e-13 -0.289689451855984 0.00044472169352925 MirTarget;miRNATAP -0.110138217681738 1.24570866635589e-05 NA NA NA hsa-miR-148a-3p MITF -0.748702855596996 3.93313343865641e-07 -0.406319701896632 0.0146105141167573 miRNATAP -0.467580582447595 3.04864215131373e-19 20644734 miR 148 regulates Mitf in melanoma cells; Furthermore miR-148 was shown to affect Mitf mRNA expression in melanoma cells through a conserved binding site in the 3'UTR sequence of mouse and human Mitf; Our data show that miR-148 and miR-137 present an additional level of regulating Mitf expression in melanocytes and melanoma cells melanoma hsa-miR-27b-3p MITF -0.823491817819754 9.20935302746823e-14 -0.406319701896632 0.0146105141167573 miRNATAP -0.179489017011341 0.0124662237784175 NA NA NA hsa-miR-192-5p MKI67 -0.50188499512787 0.00344713341196035 3.30854921974502 2.49149463242045e-41 miRNAWalker2_validate;mirMAP -0.15986443725674 0.03876631267078 NA NA NA hsa-miR-15a-5p MKL2 0.349521211668244 0.000770735998804736 0.0186170121960836 0.857399442963303 mirMAP -0.197206065415164 4.49502869981872e-05 NA NA NA hsa-miR-19b-3p MKL2 0.601279551368824 0.00016685097085251 0.0186170121960836 0.857399442963303 MirTarget;miRNATAP -0.155024095712679 5.75139732194575e-07 NA NA NA hsa-miR-21-5p MKNK2 1.51084295924322 1.54551622173259e-34 -0.0576836459714736 0.518912431453789 miRNAWalker2_validate -0.119547802728919 0.000218174804414907 NA NA NA hsa-miR-30b-5p MKRN3 -0.54056186708617 2.44688760798341e-05 2.45759898527845 1.63558898585444e-09 MirTarget -0.498814863361059 0.00153073079779387 NA NA NA hsa-miR-15a-5p MKX 0.349521211668244 0.000770735998804736 -2.29244460120159 2.37060428966561e-09 MirTarget -0.911414014248142 6.0257659627753e-07 NA NA NA hsa-miR-194-5p MLKL -0.292530160992458 0.0996141384876663 0.129902996881461 0.303454053499736 MirTarget -0.189666684359384 2.68278902801038e-08 NA NA NA hsa-miR-455-5p MLKL -0.270546034117157 0.0581320703577731 0.129902996881461 0.303454053499736 miRanda -0.241509451457751 1.30206271753994e-08 NA NA NA hsa-miR-34a-5p MLLT3 1.03694231790865 5.74864019540594e-14 -0.149677392522711 0.542059105158668 MirTarget;miRNATAP -0.25238782013817 0.00270092569600422 NA NA NA hsa-miR-455-3p MLLT3 -1.3998033821095 5.72010709806871e-17 -0.149677392522711 0.542059105158668 MirTarget -0.29104487391338 2.06725080130742e-05 NA NA NA hsa-miR-148a-3p MLLT6 -0.748702855596996 3.93313343865641e-07 0.653121837157595 1.00755151884882e-10 mirMAP -0.162803763078442 1.0554539412223e-06 NA NA NA hsa-miR-27b-3p MLPH -0.823491817819754 9.20935302746823e-14 -0.644970890675596 0.0208638141164866 MirTarget -0.529922088939426 9.40951871153178e-06 NA NA NA hsa-miR-181a-5p MLXIP 0.250113435902954 0.0551933249319293 -0.153118946482325 0.153700787364517 MirTarget -0.103833720592689 0.00976204695041358 NA NA NA hsa-miR-20a-5p MLXIP 0.854326758727003 5.04256669663285e-07 -0.153118946482325 0.153700787364517 miRNAWalker2_validate;MirTarget -0.125249220521966 3.24690509700645e-05 NA NA NA hsa-miR-15a-5p MLYCD 0.349521211668244 0.000770735998804736 -1.56369713487938 5.78200135002191e-26 MirTarget -0.297152485780833 5.96475183891688e-05 NA NA NA hsa-miR-148a-3p MMD -0.748702855596996 3.93313343865641e-07 -0.0416538737688885 0.789780769629193 miRNATAP -0.372734806931057 4.84148415492915e-14 NA NA NA hsa-miR-19b-3p MMGT1 0.601279551368824 0.00016685097085251 0.056468805450256 0.538735805487467 MirTarget;miRNATAP -0.108018715838493 9.25615675670479e-05 NA NA NA hsa-miR-455-3p MMP12 -1.3998033821095 5.72010709806871e-17 2.32747531947452 3.23493457706164e-07 MirTarget -0.734758246259244 8.77875915785385e-09 NA NA NA hsa-miR-148a-3p MMP15 -0.748702855596996 3.93313343865641e-07 -0.201202119912763 0.130626873491951 MirTarget;miRNATAP -0.120782391393074 0.00539566749823154 NA NA NA hsa-miR-19b-3p MMP16 0.601279551368824 0.00016685097085251 -0.556297005522388 0.04844968434014 mirMAP -0.29712127464201 0.000508676339841177 NA NA NA hsa-miR-20a-5p MMP16 0.854326758727003 5.04256669663285e-07 -0.556297005522388 0.04844968434014 mirMAP -0.343341610850167 1.53217272980872e-05 NA NA NA hsa-miR-30e-5p MMP16 -0.627815042856657 3.02205690184908e-10 -0.556297005522388 0.04844968434014 mirMAP -0.433297739187225 0.00146141814333037 NA NA NA hsa-miR-20a-5p MMP24 0.854326758727003 5.04256669663285e-07 0.184611798780092 0.309671788462752 MirTarget;miRNATAP -0.219332211542697 1.75072630868641e-05 NA NA NA hsa-miR-20b-5p MMP24 0.457668023910379 0.0285865211936156 0.184611798780092 0.309671788462752 MirTarget;miRNATAP -0.116478590288912 0.0058353129916503 NA NA NA hsa-miR-20a-5p MMP3 0.854326758727003 5.04256669663285e-07 0.206938536377007 0.549747904802987 MirTarget -0.30137535401111 0.00205862590490503 NA NA NA hsa-miR-455-5p MMP7 -0.270546034117157 0.0581320703577731 -2.01551939575685 0.000378454690134257 miRanda -0.544946507919829 0.00528291990396599 NA NA NA hsa-miR-451a MMP9 -2.1025161666445 6.82555767537341e-17 1.49468636413798 3.25627904376465e-05 miRNAWalker2_validate;miRTarBase -0.194578310764471 0.00392266711105327 NA NA NA hsa-miR-29c-3p MMS19 -1.4367517608807 1.61767774905781e-21 0.545909684871816 7.75436453228806e-14 miRNAWalker2_validate -0.197056404661095 4.77493173109613e-19 NA NA NA hsa-miR-15a-5p MN1 0.349521211668244 0.000770735998804736 0.163287297638916 0.495690680485637 miRTarBase -0.659870607491326 2.68347715684059e-09 NA NA NA hsa-miR-19b-3p MN1 0.601279551368824 0.00016685097085251 0.163287297638916 0.495690680485637 miRNATAP -0.191085585804532 0.00861073900155144 NA NA NA hsa-miR-455-5p MN1 -0.270546034117157 0.0581320703577731 0.163287297638916 0.495690680485637 miRanda -0.30921070712107 0.000151698928341205 NA NA NA hsa-miR-148a-3p MNT -0.748702855596996 3.93313343865641e-07 0.184227791568378 0.0189335590228023 MirTarget;miRNATAP -0.134672890349733 9.4698522376505e-08 NA NA NA hsa-miR-146b-5p MNX1 0.419719546795449 0.0457375823220155 1.06785003790784 0.00949441679457583 miRanda -0.37616076982698 7.84345633121427e-05 NA NA NA hsa-miR-21-5p MOAP1 1.51084295924322 1.54551622173259e-34 -0.300255392027902 0.000344464463896101 miRNAWalker2_validate -0.177136746595483 4.29370776021504e-09 NA NA NA hsa-miR-20a-5p MOCOS 0.854326758727003 5.04256669663285e-07 -0.6837763432576 5.79876842070152e-05 mirMAP -0.258075523792502 7.21580665037759e-08 NA NA NA hsa-miR-20b-5p MOCOS 0.457668023910379 0.0285865211936156 -0.6837763432576 5.79876842070152e-05 mirMAP -0.150736940460308 0.000148152656436108 NA NA NA hsa-miR-132-3p MOCS3 0.323796239695997 0.00272093067935091 0.0560368539268783 0.435291116463034 MirTarget -0.109748304751906 0.000662840104568353 NA NA NA hsa-miR-181a-5p MON1B 0.250113435902954 0.0551933249319293 -0.0943712249946733 0.255339014596288 mirMAP -0.132017453802056 1.77200180132381e-05 NA NA NA hsa-miR-181b-5p MON1B 0.488256489401108 0.00105321129419701 -0.0943712249946733 0.255339014596288 mirMAP -0.106062520730226 7.57870982795256e-05 NA NA NA hsa-miR-30b-5p MON1B -0.54056186708617 2.44688760798341e-05 -0.0943712249946733 0.255339014596288 mirMAP -0.118181087641542 0.000147661978529867 NA NA NA hsa-miR-132-3p MON2 0.323796239695997 0.00272093067935091 -0.365012009899068 9.80646639998691e-06 mirMAP -0.212042637120191 1.06878565006104e-08 NA NA NA hsa-miR-21-5p MON2 1.51084295924322 1.54551622173259e-34 -0.365012009899068 9.80646639998691e-06 miRNAWalker2_validate;MirTarget;mirMAP -0.220754527266474 6.21137821016038e-14 NA NA NA hsa-miR-34a-5p MON2 1.03694231790865 5.74864019540594e-14 -0.365012009899068 9.80646639998691e-06 MirTarget -0.116853361403644 3.7476309040348e-05 NA NA NA hsa-miR-181a-5p MORC3 0.250113435902954 0.0551933249319293 -0.493622872657661 7.75189399922391e-06 MirTarget -0.176747445951571 2.04554374180232e-05 NA NA NA hsa-miR-181b-5p MORC3 0.488256489401108 0.00105321129419701 -0.493622872657661 7.75189399922391e-06 MirTarget -0.1777186147211 7.71407478874961e-07 NA NA NA hsa-miR-21-5p MORC3 1.51084295924322 1.54551622173259e-34 -0.493622872657661 7.75189399922391e-06 miRNAWalker2_validate -0.336982344826891 5.83692743621512e-18 NA NA NA hsa-miR-148a-3p MOSPD1 -0.748702855596996 3.93313343865641e-07 0.488835757295254 0.000448347658243513 MirTarget;miRNATAP -0.134050229300976 0.00334048594892656 NA NA NA hsa-miR-455-3p MOSPD1 -1.3998033821095 5.72010709806871e-17 0.488835757295254 0.000448347658243513 MirTarget;PITA;miRNATAP -0.164113478458909 2.60050021653696e-05 NA NA NA hsa-miR-455-5p MOSPD1 -0.270546034117157 0.0581320703577731 0.488835757295254 0.000448347658243513 miRanda -0.150865276445092 0.00161050738525684 NA NA NA hsa-miR-455-5p MPHOSPH9 -0.270546034117157 0.0581320703577731 0.00595348107741556 0.963938661030716 miRanda -0.131334853253995 0.00345849377447286 NA NA NA hsa-miR-148a-3p MPP2 -0.748702855596996 3.93313343865641e-07 0.359448868876671 0.193649765772268 mirMAP -0.576663912966332 7.06024094033857e-11 NA NA NA hsa-miR-194-5p MPP2 -0.292530160992458 0.0996141384876663 0.359448868876671 0.193649765772268 mirMAP -0.496505194649638 2.31365296225449e-11 NA NA NA hsa-miR-29c-3p MPP2 -1.4367517608807 1.61767774905781e-21 0.359448868876671 0.193649765772268 mirMAP -0.506996501381837 1.32360246076041e-09 NA NA NA hsa-miR-34a-5p MPP2 1.03694231790865 5.74864019540594e-14 0.359448868876671 0.193649765772268 MirTarget;miRNATAP -0.331310721898384 0.000466061587201598 NA NA NA hsa-miR-181a-5p MPP5 0.250113435902954 0.0551933249319293 -0.288077654324143 0.00156212311296768 MirTarget -0.201571449433359 2.04181329475018e-09 NA NA NA hsa-miR-181b-5p MPP5 0.488256489401108 0.00105321129419701 -0.288077654324143 0.00156212311296768 MirTarget -0.186364240958831 1.66154880493207e-10 NA NA NA hsa-miR-21-5p MPP5 1.51084295924322 1.54551622173259e-34 -0.288077654324143 0.00156212311296768 miRNAWalker2_validate -0.261426709918366 3.95335462458201e-16 NA NA NA hsa-miR-192-5p MPPED2 -0.50188499512787 0.00344713341196035 0.656713801192978 0.0163326393553169 mirMAP -0.247409591002721 0.00142247867669735 NA NA NA hsa-miR-19b-3p MPPED2 0.601279551368824 0.00016685097085251 0.656713801192978 0.0163326393553169 MirTarget -0.215368275284524 0.00970596808776362 NA NA NA hsa-miR-20a-5p MPPED2 0.854326758727003 5.04256669663285e-07 0.656713801192978 0.0163326393553169 mirMAP -0.269131241664383 0.00050838119290716 NA NA NA hsa-miR-192-5p MPZL1 -0.50188499512787 0.00344713341196035 0.782707469550616 4.62671433445359e-14 miRNAWalker2_validate -0.21525697920572 2.86773310660736e-13 NA NA NA hsa-miR-19b-3p MR1 0.601279551368824 0.00016685097085251 -0.0140226098593721 0.925161101378291 mirMAP -0.203536026071139 5.74649598819883e-06 NA NA NA hsa-miR-20a-5p MR1 0.854326758727003 5.04256669663285e-07 -0.0140226098593721 0.925161101378291 mirMAP -0.184347610917532 1.07534920484514e-05 NA NA NA hsa-miR-455-5p MR1 -0.270546034117157 0.0581320703577731 -0.0140226098593721 0.925161101378291 miRanda -0.260215720622417 2.43244733903249e-07 NA NA NA hsa-miR-221-3p MRAP 1.12244756358612 3.48370308238012e-13 -1.1227534347457 0.0175857112926596 MirTarget -0.337299951028342 0.0207787687025171 NA NA NA hsa-miR-15a-5p MRAS 0.349521211668244 0.000770735998804736 0.754170829241627 1.65059029700012e-05 miRNATAP -0.198825720664118 0.0170026993462943 NA NA NA hsa-miR-181a-5p MRO 0.250113435902954 0.0551933249319293 -2.92283865752237 1.66304468359331e-30 mirMAP -0.478873367728744 2.74459295522348e-06 NA NA NA hsa-miR-181b-5p MRO 0.488256489401108 0.00105321129419701 -2.92283865752237 1.66304468359331e-30 mirMAP -0.597035693652266 9.17517440008746e-12 NA NA NA hsa-miR-30c-5p MRPL22 -0.432111642767632 0.000159764714931007 0.229402887642969 0.0120063520316233 mirMAP -0.100386732146133 0.00979305012427262 NA NA NA hsa-miR-30e-5p MRPL22 -0.627815042856657 3.02205690184908e-10 0.229402887642969 0.0120063520316233 mirMAP -0.15787190546708 0.00032545762446075 NA NA NA hsa-miR-30c-5p MRPL38 -0.432111642767632 0.000159764714931007 0.108446713558878 0.260674284695975 miRNAWalker2_validate -0.114606308937799 0.00507203194313579 NA NA NA hsa-miR-30c-5p MRPS16 -0.432111642767632 0.000159764714931007 0.171338749811962 0.0272772683436491 miRNAWalker2_validate -0.104867002230455 0.0014234122037799 NA NA NA hsa-miR-181a-5p MRPS25 0.250113435902954 0.0551933249319293 0.0188558426537258 0.840264321840341 mirMAP -0.110010129173708 0.00160842670046178 NA NA NA hsa-miR-181b-5p MRPS25 0.488256489401108 0.00105321129419701 0.0188558426537258 0.840264321840341 mirMAP -0.120754847978789 6.47664042703703e-05 NA NA NA hsa-miR-146b-5p MRS2 0.419719546795449 0.0457375823220155 0.37675345499823 4.28238645214564e-06 miRanda -0.11129983989683 3.24513187766704e-09 NA NA NA hsa-miR-146b-5p MRVI1 0.419719546795449 0.0457375823220155 0.373164450527025 0.0453434028338391 miRanda -0.104424550645751 0.015835265122672 NA NA NA hsa-miR-455-5p MS4A7 -0.270546034117157 0.0581320703577731 -1.71962200076271 7.92222790717353e-19 miRanda -0.318896556368257 3.66531833624828e-06 NA NA NA hsa-miR-30b-5p MSI2 -0.54056186708617 2.44688760798341e-05 0.659006306234202 0.000101465399699385 mirMAP -0.231184162419672 0.000337416736967968 NA NA NA hsa-miR-30e-5p MSI2 -0.627815042856657 3.02205690184908e-10 0.659006306234202 0.000101465399699385 mirMAP -0.173178599515827 0.0361525014874937 NA NA NA hsa-miR-192-5p MSN -0.50188499512787 0.00344713341196035 -0.0535957526194801 0.689537550504795 miRNAWalker2_validate;MirTarget -0.292878639001823 1.40979531895973e-15 NA NA NA hsa-miR-192-5p MSRB3 -0.50188499512787 0.00344713341196035 -0.120755130016823 0.51722938086688 miRNAWalker2_validate -0.423410475326262 8.58947258953307e-17 NA NA NA hsa-miR-20a-5p MSRB3 0.854326758727003 5.04256669663285e-07 -0.120755130016823 0.51722938086688 mirMAP -0.245890793784045 2.55192562214054e-06 NA NA NA hsa-miR-455-5p MSX2 -0.270546034117157 0.0581320703577731 -1.21361114481064 2.69643595704794e-05 miRanda -0.233563387893185 0.0195371198589052 NA NA NA hsa-miR-17-3p MTCP1 0.410352776142368 0.00422200500748636 -0.522159393260238 0.00195658202473798 MirTarget -0.162274535152001 0.00477066598810189 NA NA NA hsa-miR-30c-5p MTDH -0.432111642767632 0.000159764714931007 0.177720075923273 0.0631175983210122 miRNAWalker2_validate;miRNATAP -0.223708780739741 2.33426036396531e-08 NA NA NA hsa-miR-30e-5p MTDH -0.627815042856657 3.02205690184908e-10 0.177720075923273 0.0631175983210122 miRNATAP -0.173082298434187 0.000162718034836918 NA NA NA hsa-miR-19b-3p MTF1 0.601279551368824 0.00016685097085251 -0.000383067301068074 0.996459540723077 MirTarget -0.12224181425799 2.22997722556255e-06 NA NA NA hsa-miR-20a-5p MTF1 0.854326758727003 5.04256669663285e-07 -0.000383067301068074 0.996459540723077 MirTarget -0.144552367927515 1.45063627382606e-09 NA NA NA hsa-miR-17-3p MTHFD1 0.410352776142368 0.00422200500748636 -1.6644659291078 4.208503835821e-18 miRNAWalker2_validate -0.338397946173194 5.03664540880847e-07 NA NA NA hsa-miR-30e-5p MTHFD2 -0.627815042856657 3.02205690184908e-10 0.0234989731794792 0.901533344360344 miRNAWalker2_validate -0.311185177689665 0.000662030194643889 NA NA NA hsa-miR-132-3p MTMR10 0.323796239695997 0.00272093067935091 -0.348582480627911 0.000141222859443133 miRNAWalker2_validate;MirTarget -0.352521032978802 1.16136147322015e-18 NA NA NA hsa-miR-21-5p MTMR12 1.51084295924322 1.54551622173259e-34 -0.30433091231081 8.46080653212321e-05 miRNAWalker2_validate;miRNATAP -0.153608728333415 3.79045501898405e-08 NA NA NA hsa-miR-34a-5p MTMR2 1.03694231790865 5.74864019540594e-14 0.400709772822859 0.00100054348711912 miRNAWalker2_validate -0.174181016007212 2.96323571167438e-05 NA NA NA hsa-miR-19b-3p MTMR6 0.601279551368824 0.00016685097085251 -0.438933829344032 1.45894330320039e-06 MirTarget -0.100571603351265 0.000300681180305264 NA NA NA hsa-miR-21-5p MTMR9 1.51084295924322 1.54551622173259e-34 -0.787590544067709 5.77939416034669e-15 miRNAWalker2_validate -0.204464978203831 4.90417157828363e-08 NA NA NA hsa-miR-34a-5p MTMR9 1.03694231790865 5.74864019540594e-14 -0.787590544067709 5.77939416034669e-15 miRNAWalker2_validate -0.175522674385689 7.07460384241347e-07 NA NA NA hsa-miR-132-3p MTO1 0.323796239695997 0.00272093067935091 -0.454949779396419 3.1940905112147e-07 mirMAP -0.138986428641975 0.000630772153032758 NA NA NA hsa-miR-181b-5p MTOR 0.488256489401108 0.00105321129419701 0.127337008584315 0.234493252196033 miRNAWalker2_validate -0.222677068776147 6.82613635172636e-11 NA NA NA hsa-miR-30b-5p MTR -0.54056186708617 2.44688760798341e-05 0.570575904059039 1.01722538415224e-05 mirMAP -0.122950653400998 0.0129180203251318 NA NA NA hsa-miR-182-5p MTSS1 1.96601340710222 4.39326175603633e-09 -0.158641289745661 0.2101510371787 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.125852646034016 7.14227162775029e-13 22681717;23474751 MicroRNA 182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma; Metastasis suppressor 1 MTSS1 one target gene of miR-182 plays an important role in the metastasis of cancers; The expression of MTSS1 was evaluated by immunohistochemistry and western blot in the above tissues and its correlation with miR-182 expression was analyzed; In addition luciferase assays was performed to confirm the regulation of miR-182 on MTSS1; Compared with normal tissue miR-182 was up-regulated and MTSS1 was down-regulated in HCC tissues; There was a negative correlation between miR-182 and MTSS1 expression in both HCC tissues r = -0.673 p < 0.01 and HCC cell lines r = -0.931 p = 0.021; Furthermore the up-regulation of miR-182 resulted in the down-regulation of MTSS1 and increased invasive potential of HUH-1 and reverse results were also confirmed when the expression of miR-182 was inhibited;Suppression of MIM by microRNA 182 activates RhoA and promotes breast cancer metastasis; In breast tumor samples miR-182 induction is linked to downregulation of MIM RhoA activation and poor prognosis metastasis;metastasis;worse prognosis liver cancer;breast cancer hsa-miR-19b-3p MTUS1 0.601279551368824 0.00016685097085251 -0.739466595648691 1.26108348307137e-08 miRNATAP -0.243818942094714 5.97032365061239e-10 NA NA NA hsa-miR-20a-5p MUC20 0.854326758727003 5.04256669663285e-07 -0.24196350030529 0.404864489685391 mirMAP -0.175175343045231 0.0334308652631991 NA NA NA hsa-miR-20b-5p MUC20 0.457668023910379 0.0285865211936156 -0.24196350030529 0.404864489685391 mirMAP -0.145891901972626 0.0311393878024263 NA NA NA hsa-miR-148a-3p MXRA7 -0.748702855596996 3.93313343865641e-07 0.0792703555372567 0.610154190820347 mirMAP -0.327411438179438 4.10632025038244e-11 NA NA NA hsa-miR-30e-5p MXRA7 -0.627815042856657 3.02205690184908e-10 0.0792703555372567 0.610154190820347 mirMAP -0.241294152385355 0.00126398022739826 NA NA NA hsa-miR-34a-5p MYADM 1.03694231790865 5.74864019540594e-14 -0.876765995225898 5.02636856478243e-11 MirTarget -0.186957486108053 6.1209350661734e-05 NA NA NA hsa-miR-192-5p MYB -0.50188499512787 0.00344713341196035 0.832619773672674 0.00191922988334194 miRNAWalker2_validate -0.161558899446576 0.0348070283826992 NA NA NA hsa-miR-34a-5p MYB 1.03694231790865 5.74864019540594e-14 0.832619773672674 0.00191922988334194 miRNAWalker2_validate;miRTarBase -0.28113576142756 0.00236602949553086 NA NA NA hsa-miR-148a-3p MYBL1 -0.748702855596996 3.93313343865641e-07 1.1480718167108 4.98869165631426e-13 miRNATAP -0.223597573663347 2.53522339869195e-05 NA NA NA hsa-miR-29c-3p MYBL2 -1.4367517608807 1.61767774905781e-21 4.08434617053484 2.28158156759939e-36 miRNATAP -1.34170681129874 3.72972269659478e-42 NA NA NA hsa-miR-30c-5p MYBL2 -0.432111642767632 0.000159764714931007 4.08434617053484 2.28158156759939e-36 MirTarget;miRNATAP -0.366526653110521 0.0154861779160844 NA NA NA hsa-miR-30e-5p MYBL2 -0.627815042856657 3.02205690184908e-10 4.08434617053484 2.28158156759939e-36 miRTarBase;MirTarget -0.987211085918653 5.06046826522651e-09 NA NA NA hsa-miR-20a-5p MYC 0.854326758727003 5.04256669663285e-07 -1.53204423111148 3.53987625613016e-10 miRNAWalker2_validate -0.165031814042356 0.0197576054298013 26012475 Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex colon cancer hsa-miR-21-5p MYCBP2 1.51084295924322 1.54551622173259e-34 -0.593972864681513 6.8369331659891e-07 miRNAWalker2_validate -0.207075485776808 2.20253115650157e-06 NA NA NA hsa-miR-29c-3p MYCN -1.4367517608807 1.61767774905781e-21 2.4097398140758 1.13995179469792e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.574376350076033 8.3662216909109e-07 NA NA NA hsa-miR-30e-5p MYEF2 -0.627815042856657 3.02205690184908e-10 0.808248214059432 0.0267356184561659 mirMAP -0.414952863133364 0.0189593689873397 NA NA NA hsa-miR-455-5p MYEF2 -0.270546034117157 0.0581320703577731 0.808248214059432 0.0267356184561659 miRanda -0.422974938895063 0.000703599869023022 NA NA NA hsa-miR-146b-5p MYH11 0.419719546795449 0.0457375823220155 -0.692628128167121 0.0185658225542382 miRanda -0.205763275523651 0.00257943366034807 NA NA NA hsa-miR-19b-3p MYH11 0.601279551368824 0.00016685097085251 -0.692628128167121 0.0185658225542382 MirTarget -0.251177183856488 0.00502193768934567 NA NA NA hsa-miR-19b-3p MYLIP 0.601279551368824 0.00016685097085251 0.210233410108909 0.114112793362647 miRNAWalker2_validate;miRTarBase;MirTarget -0.110383193788102 0.00623443696489503 NA NA NA hsa-miR-455-5p MYLIP -0.270546034117157 0.0581320703577731 0.210233410108909 0.114112793362647 MirTarget;PITA;miRanda;miRNATAP -0.297912978382436 2.14334790338261e-11 NA NA NA hsa-miR-146b-5p MYLK 0.419719546795449 0.0457375823220155 -1.14236369623552 6.9999057137519e-11 miRanda -0.158511280553425 0.00012794381552573 NA NA NA hsa-miR-15a-5p MYLK 0.349521211668244 0.000770735998804736 -1.14236369623552 6.9999057137519e-11 MirTarget;miRNATAP -0.224315263940168 0.00792609402220537 NA NA NA hsa-miR-409-3p MYLK -0.499649792570937 0.0526751181520117 -1.14236369623552 6.9999057137519e-11 MirTarget;PITA -0.147159859350932 1.18335044196222e-05 NA NA NA hsa-miR-20a-5p MYO10 0.854326758727003 5.04256669663285e-07 -1.59578787890497 5.76385780041621e-13 miRNATAP -0.365311951533274 9.32436479754336e-09 NA NA NA hsa-miR-221-3p MYO10 1.12244756358612 3.48370308238012e-13 -1.59578787890497 5.76385780041621e-13 MirTarget;miRNATAP -0.155827611349414 0.0264178140204685 NA NA NA hsa-miR-455-5p MYO10 -0.270546034117157 0.0581320703577731 -1.59578787890497 5.76385780041621e-13 miRanda -0.169010818111052 0.030659069522988 NA NA NA hsa-miR-432-5p MYO1B -0.536178819038888 0.0748623258271085 -1.35871038040116 5.51897953328734e-21 miRNATAP -0.103483404130238 2.3874544168609e-05 NA NA NA hsa-miR-148a-3p MYO5A -0.748702855596996 3.93313343865641e-07 0.557773632662129 0.000490007069603743 mirMAP -0.345280552201393 1.79580634840643e-11 NA NA NA hsa-miR-17-3p MYO5A 0.410352776142368 0.00422200500748636 0.557773632662129 0.000490007069603743 mirMAP -0.126237724132971 0.0210648686021072 NA NA NA hsa-miR-194-5p MYO5A -0.292530160992458 0.0996141384876663 0.557773632662129 0.000490007069603743 mirMAP -0.272279442255365 3.31729877422094e-10 NA NA NA hsa-miR-19b-3p MYO5A 0.601279551368824 0.00016685097085251 0.557773632662129 0.000490007069603743 mirMAP -0.14760431230917 0.00248371280991244 NA NA NA hsa-miR-20a-5p MYO5A 0.854326758727003 5.04256669663285e-07 0.557773632662129 0.000490007069603743 mirMAP -0.166408397175256 0.00024596073719397 NA NA NA hsa-miR-30b-5p MYO5A -0.54056186708617 2.44688760798341e-05 0.557773632662129 0.000490007069603743 mirMAP;miRNATAP -0.178977764379017 0.00329302806872398 NA NA NA hsa-miR-181b-5p MYO5B 0.488256489401108 0.00105321129419701 -0.176936939172443 0.203327370730779 mirMAP -0.311706557903158 1.7557541578634e-12 NA NA NA hsa-miR-30b-5p MYO5B -0.54056186708617 2.44688760798341e-05 -0.176936939172443 0.203327370730779 mirMAP -0.249376692132998 1.72673241045392e-06 NA NA NA hsa-miR-146b-5p MYO5C 0.419719546795449 0.0457375823220155 0.704041865777547 1.35098259847515e-06 miRanda -0.117525972766176 0.000560965803984318 NA NA NA hsa-miR-455-5p MYO6 -0.270546034117157 0.0581320703577731 -0.0102768547102698 0.938333318335632 miRanda -0.196115329403408 1.33246317872634e-05 NA NA NA hsa-miR-181a-5p MYO9A 0.250113435902954 0.0551933249319293 -1.00759496257002 7.50264844143602e-06 mirMAP -0.263321280972173 0.00199588196727032 NA NA NA hsa-miR-181b-5p MYO9A 0.488256489401108 0.00105321129419701 -1.00759496257002 7.50264844143602e-06 mirMAP -0.23594270315154 0.00144804532065528 NA NA NA hsa-miR-21-5p MYO9A 1.51084295924322 1.54551622173259e-34 -1.00759496257002 7.50264844143602e-06 miRNAWalker2_validate -0.453185104639855 3.01731319012402e-08 NA NA NA hsa-miR-30b-5p MYO9A -0.54056186708617 2.44688760798341e-05 -1.00759496257002 7.50264844143602e-06 mirMAP -0.296623875159399 0.000555965954306298 NA NA NA hsa-miR-30b-5p MYSM1 -0.54056186708617 2.44688760798341e-05 0.039132402304356 0.842818200667781 mirMAP -0.161746385428245 0.0305625726812482 NA NA NA hsa-miR-21-5p N4BP2L1 1.51084295924322 1.54551622173259e-34 -1.71399858767707 1.0517231633165e-27 MirTarget -0.739815199438225 2.03614634263877e-40 NA NA NA hsa-miR-192-5p N4BP3 -0.50188499512787 0.00344713341196035 1.8217286140426 3.52289215295134e-19 mirMAP -0.438310435315736 7.94117558497158e-14 NA NA NA hsa-miR-29c-3p N4BP3 -1.4367517608807 1.61767774905781e-21 1.8217286140426 3.52289215295134e-19 mirMAP -0.368710212242618 1.12681242488956e-08 NA NA NA hsa-miR-505-5p N4BP3 -0.768282569967001 1.14662846595407e-05 1.8217286140426 3.52289215295134e-19 mirMAP -0.320493088735481 3.23205812857491e-08 NA NA NA hsa-miR-181a-5p NAA30 0.250113435902954 0.0551933249319293 -0.454004458262681 8.01308724482182e-10 mirMAP -0.11115773013517 7.20940846357765e-05 NA NA NA hsa-miR-181b-5p NAA30 0.488256489401108 0.00105321129419701 -0.454004458262681 8.01308724482182e-10 mirMAP -0.108278485449583 8.36100022820392e-06 NA NA NA hsa-miR-21-5p NAA30 1.51084295924322 1.54551622173259e-34 -0.454004458262681 8.01308724482182e-10 miRNAWalker2_validate;MirTarget -0.225387831025051 1.09431284378073e-17 NA NA NA hsa-miR-29c-3p NAA40 -1.4367517608807 1.61767774905781e-21 1.03189170931086 9.06044364623226e-21 MirTarget;miRNATAP -0.337041319215079 1.76726037272012e-23 NA NA NA hsa-miR-146b-5p NAALADL2 0.419719546795449 0.0457375823220155 -2.03717143238746 1.35038942458769e-12 miRanda -0.188408668414067 0.00597231275681723 NA NA NA hsa-miR-19b-3p NAALADL2 0.601279551368824 0.00016685097085251 -2.03717143238746 1.35038942458769e-12 MirTarget -0.414947101161793 3.16116216605599e-06 NA NA NA hsa-miR-132-3p NAB1 0.323796239695997 0.00272093067935091 -0.63838841312247 6.55627584170104e-14 MirTarget -0.102463622403159 0.00986922111905401 NA NA NA hsa-miR-30c-5p NACC2 -0.432111642767632 0.000159764714931007 0.183092329359772 0.117391567370094 mirMAP;miRNATAP -0.119129618835195 0.0166635528530967 NA NA NA hsa-miR-30b-5p NAGPA -0.54056186708617 2.44688760798341e-05 0.723959751497631 2.19291944786425e-12 MirTarget -0.10237135462302 0.0106595537499639 NA NA NA hsa-miR-30c-5p NAGPA -0.432111642767632 0.000159764714931007 0.723959751497631 2.19291944786425e-12 MirTarget;miRNATAP -0.123007499463787 0.00630705951854814 NA NA NA hsa-miR-30e-5p NAGPA -0.627815042856657 3.02205690184908e-10 0.723959751497631 2.19291944786425e-12 MirTarget -0.210721505472967 3.34533405883967e-05 NA NA NA hsa-miR-455-5p NAIP -0.270546034117157 0.0581320703577731 0.321717102046791 0.104126589295581 miRanda -0.260451867053439 0.000113038289548375 NA NA NA hsa-miR-29c-3p NANP -1.4367517608807 1.61767774905781e-21 0.204006333758349 0.00721211432067055 MirTarget -0.116024687610955 4.80280360294185e-07 NA NA NA hsa-miR-148a-3p NAP1L1 -0.748702855596996 3.93313343865641e-07 0.48873822323481 4.44413744556636e-06 MirTarget -0.222421584730968 9.79324697889936e-11 NA NA NA hsa-miR-30b-5p NAP1L2 -0.54056186708617 2.44688760798341e-05 -0.777872498045082 0.0331551365188119 MirTarget -0.360587271107341 0.00931740851509571 NA NA NA hsa-miR-455-5p NAP1L2 -0.270546034117157 0.0581320703577731 -0.777872498045082 0.0331551365188119 miRanda -0.600681488841242 1.27968982648746e-06 NA NA NA hsa-miR-221-3p NAP1L5 1.12244756358612 3.48370308238012e-13 -1.29692509941602 3.32250714880114e-12 MirTarget;miRNATAP -0.34607457043993 2.16429669348486e-09 NA NA NA hsa-miR-222-3p NAP1L5 1.08574156066353 1.76407192348131e-11 -1.29692509941602 3.32250714880114e-12 MirTarget;miRNATAP -0.304462180896109 4.54631285270591e-08 NA NA NA hsa-miR-29c-3p NAPB -1.4367517608807 1.61767774905781e-21 0.506566982332465 2.85103710572652e-09 MirTarget -0.117778475289939 8.46038942493822e-06 NA NA NA hsa-miR-15a-5p NAPG 0.349521211668244 0.000770735998804736 -0.0147809048331702 0.839524435921277 MirTarget -0.134279554566577 7.63384321401422e-05 NA NA NA hsa-miR-29c-3p NASP -1.4367517608807 1.61767774905781e-21 0.461088662260567 4.0113762566776e-06 MirTarget -0.231584591038966 1.39634371145357e-14 NA NA NA hsa-miR-148a-3p NAT14 -0.748702855596996 3.93313343865641e-07 0.762454549118796 2.23303909352019e-05 miRNATAP -0.456270487898184 1.74702579708855e-15 NA NA NA hsa-miR-148a-3p NAT8L -0.748702855596996 3.93313343865641e-07 1.21195978404762 0.000153977148692105 MirTarget -0.624254951064272 1.68451566801213e-09 NA NA NA hsa-miR-192-5p NAT8L -0.50188499512787 0.00344713341196035 1.21195978404762 0.000153977148692105 mirMAP -0.607552074927247 1.05556548107848e-11 NA NA NA hsa-miR-27b-3p NAT8L -0.823491817819754 9.20935302746823e-14 1.21195978404762 0.000153977148692105 miRNATAP -0.418909031811915 0.00255056833285611 NA NA NA hsa-miR-29c-3p NAT8L -1.4367517608807 1.61767774905781e-21 1.21195978404762 0.000153977148692105 mirMAP -0.393525525042715 6.77712174117684e-05 NA NA NA hsa-miR-15a-5p NAV1 0.349521211668244 0.000770735998804736 0.457357293208876 0.00149629098704196 MirTarget;miRNATAP -0.221414805635224 0.00111985814953711 NA NA NA hsa-miR-192-3p NAV1 -0.6401165114007 0.000266272092403814 0.457357293208876 0.00149629098704196 mirMAP -0.376693117758458 2.31058917756512e-23 NA NA NA hsa-miR-19b-3p NAV1 0.601279551368824 0.00016685097085251 0.457357293208876 0.00149629098704196 mirMAP;miRNATAP -0.17794986389108 4.58018360451454e-05 NA NA NA hsa-miR-27b-3p NAV1 -0.823491817819754 9.20935302746823e-14 0.457357293208876 0.00149629098704196 miRNATAP -0.154734556101065 0.0130129836680515 NA NA NA hsa-miR-30e-5p NAV1 -0.627815042856657 3.02205690184908e-10 0.457357293208876 0.00149629098704196 mirMAP -0.274822633943669 7.68655501841317e-05 NA NA NA hsa-miR-148a-3p NBEA -0.748702855596996 3.93313343865641e-07 -0.95438160847924 0.000354673661355781 miRNATAP -0.517605225217207 2.06161972192119e-09 NA NA NA hsa-miR-192-3p NBEA -0.6401165114007 0.000266272092403814 -0.95438160847924 0.000354673661355781 MirTarget -0.323105158273243 1.18173126347165e-05 NA NA NA hsa-miR-194-5p NBEA -0.292530160992458 0.0996141384876663 -0.95438160847924 0.000354673661355781 miRNATAP -0.404246436092162 2.85843770275539e-08 NA NA NA hsa-miR-146b-5p NBEAL1 0.419719546795449 0.0457375823220155 -0.743165914970633 5.52240194593875e-06 miRanda -0.168337623476659 9.5205696927009e-06 NA NA NA hsa-miR-20a-5p NBL1 0.854326758727003 5.04256669663285e-07 0.411559687908337 0.0538190096622874 miRNATAP -0.212576305873646 0.00042454664006649 NA NA NA hsa-miR-146b-5p NBPF10 0.419719546795449 0.0457375823220155 -0.378706866017082 0.187738689520688 miRanda -0.241039820294495 0.000282996900700471 NA NA NA hsa-miR-15a-5p NBR1 0.349521211668244 0.000770735998804736 -0.387955725178678 1.49342788712596e-05 MirTarget -0.203715646663672 1.26717688186442e-06 NA NA NA hsa-miR-148a-3p NCAM1 -0.748702855596996 3.93313343865641e-07 -3.20651653818541 4.82483086836138e-22 miRNATAP -0.269720143732448 0.0186234539799905 NA NA NA hsa-miR-224-3p NCAM1 1.40770116795301 1.31426607144612e-08 -3.20651653818541 4.82483086836138e-22 MirTarget -0.210440029638278 0.00213630882871295 NA NA NA hsa-miR-192-5p NCAPH -0.50188499512787 0.00344713341196035 3.18695185270844 3.33326623129278e-40 miRNAWalker2_validate -0.26091051426793 0.000505758185848569 NA NA NA hsa-miR-215-5p NCAPH -0.981544773246509 3.14452272477156e-05 3.18695185270844 3.33326623129278e-40 miRNAWalker2_validate -0.191147550592609 0.000419239330312899 NA NA NA hsa-miR-192-5p NCEH1 -0.50188499512787 0.00344713341196035 -0.168281646804029 0.373785981981435 miRNAWalker2_validate -0.372404785674142 9.68584824490217e-13 NA NA NA hsa-miR-20a-5p NCEH1 0.854326758727003 5.04256669663285e-07 -0.168281646804029 0.373785981981435 MirTarget -0.217192619044951 4.49941518756095e-05 NA NA NA hsa-miR-34a-5p NCEH1 1.03694231790865 5.74864019540594e-14 -0.168281646804029 0.373785981981435 miRNATAP -0.222446376957437 0.000588415512385712 NA NA NA hsa-miR-146b-5p NCK2 0.419719546795449 0.0457375823220155 -0.0215428774682662 0.91249283819926 miRanda -0.126970863433227 0.0051112815012138 NA NA NA hsa-miR-30e-5p NCK2 -0.627815042856657 3.02205690184908e-10 -0.0215428774682662 0.91249283819926 miRNATAP -0.193329853995882 0.0413248112508621 NA NA NA hsa-miR-505-5p NCK2 -0.768282569967001 1.14662846595407e-05 -0.0215428774682662 0.91249283819926 MirTarget;miRNATAP -0.140011547553508 0.00955335295979552 NA NA NA hsa-miR-19b-3p NCKAP5 0.601279551368824 0.00016685097085251 -1.99554121140322 2.30439992781689e-15 miRNAWalker2_validate;MirTarget -0.297569071821137 0.000163888687478389 NA NA NA hsa-miR-20a-5p NCKAP5 0.854326758727003 5.04256669663285e-07 -1.99554121140322 2.30439992781689e-15 MirTarget;miRNATAP -0.34172743550512 3.13490750141241e-06 NA NA NA hsa-miR-455-5p NCKAP5 -0.270546034117157 0.0581320703577731 -1.99554121140322 2.30439992781689e-15 miRanda -0.214970590316547 0.0162426272445935 NA NA NA hsa-miR-29c-3p NCKAP5L -1.4367517608807 1.61767774905781e-21 0.108475746464931 0.422813107286325 miRNATAP -0.188985226749027 4.51490068434876e-06 NA NA NA hsa-miR-29c-3p NCOA3 -1.4367517608807 1.61767774905781e-21 0.177253631549581 0.0707264527612757 miRNATAP -0.160772738928886 6.25568785248e-08 NA NA NA hsa-miR-30b-5p NCOA6 -0.54056186708617 2.44688760798341e-05 0.424079598528568 7.75958285971715e-07 miRNAWalker2_validate -0.101798182107663 0.00189287298155212 NA NA NA hsa-miR-455-5p NCOA7 -0.270546034117157 0.0581320703577731 -1.0880284499043 5.27567246510644e-11 miRanda -0.173027198129216 0.00287775086092327 NA NA NA hsa-miR-29c-3p NCOR2 -1.4367517608807 1.61767774905781e-21 0.534673791894968 2.12570475503387e-10 miRNATAP -0.156976806568187 1.39279933464e-09 NA NA NA hsa-miR-15a-5p NCS1 0.349521211668244 0.000770735998804736 0.264220147058111 0.258470388947291 MirTarget;miRNATAP -0.257638404740833 0.0193820964154022 NA NA NA hsa-miR-192-3p NCS1 -0.6401165114007 0.000266272092403814 0.264220147058111 0.258470388947291 mirMAP -0.52393623851935 3.48140138962054e-17 NA NA NA hsa-miR-29c-3p NCS1 -1.4367517608807 1.61767774905781e-21 0.264220147058111 0.258470388947291 mirMAP -0.158246954871436 0.0279894267896338 NA NA NA hsa-miR-99a-5p NCS1 -1.51481656384839 3.93230057259529e-14 0.264220147058111 0.258470388947291 mirMAP -0.294688217085456 5.90978228425764e-08 NA NA NA hsa-miR-192-5p NDE1 -0.50188499512787 0.00344713341196035 0.525156796072816 3.72868495053221e-06 miRNAWalker2_validate -0.164692563352345 2.91127523917972e-07 NA NA NA hsa-miR-20a-5p NDEL1 0.854326758727003 5.04256669663285e-07 -0.93256260809174 5.64997674586862e-21 MirTarget;miRNATAP -0.135613977825564 3.51075440125052e-06 NA NA NA hsa-miR-221-3p NDFIP1 1.12244756358612 3.48370308238012e-13 -0.228407565966697 0.00532073775853203 miRNAWalker2_validate -0.149849589513468 1.33268201682902e-09 NA NA NA hsa-miR-181a-5p NDFIP2 0.250113435902954 0.0551933249319293 -0.965495107934266 1.87718124112122e-18 mirMAP -0.222139749453408 1.82625469511563e-07 NA NA NA hsa-miR-181b-5p NDFIP2 0.488256489401108 0.00105321129419701 -0.965495107934266 1.87718124112122e-18 mirMAP -0.247064458758544 1.56527663101575e-11 NA NA NA hsa-miR-148a-3p NDOR1 -0.748702855596996 3.93313343865641e-07 1.05020501516652 5.12624788472277e-23 mirMAP -0.198297115609242 4.09966479091354e-08 NA NA NA hsa-miR-20a-5p NDRG4 0.854326758727003 5.04256669663285e-07 -0.54286699943328 0.0347192341596574 mirMAP -0.16047481349172 0.0280038658884103 NA NA NA hsa-miR-29c-3p NDST1 -1.4367517608807 1.61767774905781e-21 0.772480980277764 3.45707692578057e-12 mirMAP;miRNATAP -0.167080755157913 1.47329738252757e-06 NA NA NA hsa-miR-221-3p NDST3 1.12244756358612 3.48370308238012e-13 -5.21438460909548 2.47688530616434e-64 MirTarget -0.506438753862259 4.32396104959882e-06 NA NA NA hsa-miR-222-3p NDST3 1.08574156066353 1.76407192348131e-11 -5.21438460909548 2.47688530616434e-64 MirTarget -0.492543489537869 3.17396134535774e-06 NA NA NA hsa-miR-132-3p NDUFB10 0.323796239695997 0.00272093067935091 -0.0459910243582433 0.692515103252967 miRNAWalker2_validate -0.123085965176094 0.0193102012618997 NA NA NA hsa-miR-221-3p NDUFS1 1.12244756358612 3.48370308238012e-13 -0.676344923057284 6.13862508636795e-12 miRNAWalker2_validate -0.205293687765296 1.14953251431145e-11 NA NA NA hsa-miR-27b-3p NDUFS6 -0.823491817819754 9.20935302746823e-14 0.529305162889796 3.55320960048051e-05 miRNAWalker2_validate -0.120698677984857 0.0300386866553856 NA NA NA hsa-miR-146a-5p NEB -0.742958238440575 0.000765983177482633 2.15292878143338 1.03240129364552e-08 MirTarget -0.234574006131002 0.00526366806211578 NA NA NA hsa-miR-148a-3p NEBL -0.748702855596996 3.93313343865641e-07 -1.60837717002858 3.41970971707568e-05 mirMAP -0.515068828584662 5.20804366302462e-05 NA NA NA hsa-miR-192-5p NEBL -0.50188499512787 0.00344713341196035 -1.60837717002858 3.41970971707568e-05 mirMAP -0.444164748552869 5.79787961566426e-05 NA NA NA hsa-miR-27b-3p NECAB1 -0.823491817819754 9.20935302746823e-14 -0.000563338784403067 0.99830111759913 MirTarget -0.292100236329217 0.0103193271064198 NA NA NA hsa-miR-30b-5p NEDD4 -0.54056186708617 2.44688760798341e-05 -0.211886112092802 0.209669364741357 MirTarget;miRNATAP -0.280511620377521 9.91800867972182e-06 NA NA NA hsa-miR-127-3p NEDD4L -1.0751374948053 2.19322892330221e-05 0.864887679249782 8.63340597856756e-11 miRanda -0.103123811198301 6.5047114824905e-05 NA NA NA hsa-miR-30b-5p NEDD4L -0.54056186708617 2.44688760798341e-05 0.864887679249782 8.63340597856756e-11 miRNATAP -0.183108453165057 0.000375567318706755 NA NA NA hsa-miR-30c-5p NEDD4L -0.432111642767632 0.000159764714931007 0.864887679249782 8.63340597856756e-11 miRNATAP -0.142740549883177 0.0140144631398212 NA NA NA hsa-miR-20b-5p NEDD9 0.457668023910379 0.0285865211936156 -0.00645871831418354 0.968927148892877 mirMAP -0.102212895928035 0.00798207607459967 NA NA NA hsa-miR-21-5p NEK1 1.51084295924322 1.54551622173259e-34 -0.421013421815401 0.00013611043051042 miRNAWalker2_validate -0.217073502904145 5.42988662846301e-08 NA NA NA hsa-miR-27b-3p NEK2 -0.823491817819754 9.20935302746823e-14 4.21788709235454 1.27998914185694e-50 miRNATAP -0.775511487038549 1.1163500997741e-08 NA NA NA hsa-miR-181b-5p NEK3 0.488256489401108 0.00105321129419701 0.398398228720978 0.0233441139517675 miRNAWalker2_validate -0.279182502290718 9.0191751853468e-07 NA NA NA hsa-miR-192-3p NEO1 -0.6401165114007 0.000266272092403814 -0.0479925722932082 0.674278574877372 miRNATAP -0.168262517396454 5.81670021015279e-08 NA NA NA hsa-miR-132-3p NET1 0.323796239695997 0.00272093067935091 -0.257283308116178 0.00689999829857687 miRNATAP -0.189732392148208 9.49010505673641e-06 NA NA NA hsa-miR-17-3p NEU3 0.410352776142368 0.00422200500748636 -0.0922777632719871 0.656503691679937 MirTarget -0.149598299571391 0.033936212530184 NA NA NA hsa-miR-30b-5p NEU3 -0.54056186708617 2.44688760798341e-05 -0.0922777632719871 0.656503691679937 mirMAP -0.250194145599542 0.00141355699628294 NA NA NA hsa-miR-148a-3p NEURL4 -0.748702855596996 3.93313343865641e-07 0.227746874329284 0.00320954632248109 MirTarget;miRNATAP -0.112466163069294 6.8940335334216e-06 NA NA NA hsa-miR-15a-5p NF1 0.349521211668244 0.000770735998804736 -0.152901353808947 0.101850652339859 MirTarget -0.148929467960257 0.000666418015083739 NA NA NA hsa-miR-455-5p NF1 -0.270546034117157 0.0581320703577731 -0.152901353808947 0.101850652339859 miRanda -0.117633756266104 0.00021315047674953 NA NA NA hsa-miR-29c-3p NF2 -1.4367517608807 1.61767774905781e-21 0.664388802089412 1.31735413428132e-13 mirMAP -0.158125558632293 1.55838293866251e-08 NA NA NA hsa-miR-148a-3p NFAM1 -0.748702855596996 3.93313343865641e-07 -1.5126511002004 1.93686430698698e-15 mirMAP -0.282215369366512 1.02973421453975e-05 NA NA NA hsa-miR-34a-5p NFAM1 1.03694231790865 5.74864019540594e-14 -1.5126511002004 1.93686430698698e-15 MirTarget -0.251383008693486 0.000195321186858465 NA NA NA hsa-miR-15a-5p NFASC 0.349521211668244 0.000770735998804736 -0.522066844629388 0.0155574931536179 MirTarget -0.373599235179838 0.000231747953659862 NA NA NA hsa-miR-17-3p NFASC 0.410352776142368 0.00422200500748636 -0.522066844629388 0.0155574931536179 MirTarget -0.210311981102736 0.0041958542833011 NA NA NA hsa-miR-19b-3p NFASC 0.601279551368824 0.00016685097085251 -0.522066844629388 0.0155574931536179 mirMAP -0.189615923400414 0.00386614344346015 NA NA NA hsa-miR-20a-5p NFASC 0.854326758727003 5.04256669663285e-07 -0.522066844629388 0.0155574931536179 mirMAP -0.258189779448579 2.21454270602185e-05 NA NA NA hsa-miR-17-3p NFAT5 0.410352776142368 0.00422200500748636 -0.326144498869474 0.00164314559569324 mirMAP -0.104599542268839 0.00299701612631111 NA NA NA hsa-miR-192-3p NFAT5 -0.6401165114007 0.000266272092403814 -0.326144498869474 0.00164314559569324 MirTarget;miRNATAP -0.128669502769738 6.06524882230981e-06 NA NA NA hsa-miR-194-5p NFAT5 -0.292530160992458 0.0996141384876663 -0.326144498869474 0.00164314559569324 miRNATAP -0.121386239180467 1.81500128575235e-05 NA NA NA hsa-miR-21-5p NFAT5 1.51084295924322 1.54551622173259e-34 -0.326144498869474 0.00164314559569324 miRNAWalker2_validate;mirMAP -0.110763353790018 0.00341649802767152 NA NA NA hsa-miR-455-5p NFATC1 -0.270546034117157 0.0581320703577731 -0.746396319507337 4.35096501526645e-05 miRanda -0.308343970820935 7.69222772176338e-07 NA NA NA hsa-miR-15a-5p NFATC3 0.349521211668244 0.000770735998804736 -0.644444487566839 5.42635056668801e-13 MirTarget;miRNATAP -0.140535010330653 0.0011067840013694 NA NA NA hsa-miR-222-3p NFATC3 1.08574156066353 1.76407192348131e-11 -0.644444487566839 5.42635056668801e-13 MirTarget;miRNATAP -0.132741702448246 6.9873783779618e-07 NA NA NA hsa-miR-29c-3p NFATC4 -1.4367517608807 1.61767774905781e-21 0.864010892322999 1.90169048902368e-05 miRNATAP -0.144412784703952 0.0215414373459198 NA NA NA hsa-miR-15a-5p NFE2L1 0.349521211668244 0.000770735998804736 0.0185639503970148 0.845911916772548 miRNATAP -0.129466007382189 0.00381612234124097 NA NA NA hsa-miR-132-3p NFE2L2 0.323796239695997 0.00272093067935091 -0.957109369492801 9.99737994383364e-19 MirTarget -0.2117677438712 3.21478423821807e-05 NA NA NA hsa-miR-19b-3p NFIA 0.601279551368824 0.00016685097085251 -0.924685216157224 2.60745966247054e-13 miRNATAP -0.205664359100484 1.38121234653324e-07 NA NA NA hsa-miR-20a-5p NFIA 0.854326758727003 5.04256669663285e-07 -0.924685216157224 2.60745966247054e-13 mirMAP -0.220307604692219 1.17522520181388e-09 NA NA NA hsa-miR-20b-5p NFIA 0.457668023910379 0.0285865211936156 -0.924685216157224 2.60745966247054e-13 mirMAP -0.124870652536193 3.37991819917738e-05 NA NA NA hsa-miR-21-5p NFIA 1.51084295924322 1.54551622173259e-34 -0.924685216157224 2.60745966247054e-13 MirTarget;miRNATAP -0.531732418939975 5.46694443575908e-34 NA NA NA hsa-miR-409-3p NFIA -0.499649792570937 0.0526751181520117 -0.924685216157224 2.60745966247054e-13 mirMAP -0.119709116625505 8.40021342754261e-07 NA NA NA hsa-miR-132-3p NFIB 0.323796239695997 0.00272093067935091 -0.473125743246742 0.000230272053316789 mirMAP;miRNATAP -0.291331588293801 4.90129588510581e-07 NA NA NA hsa-miR-17-3p NFIB 0.410352776142368 0.00422200500748636 -0.473125743246742 0.000230272053316789 MirTarget;miRNATAP -0.233220539336301 7.30513616336245e-08 NA NA NA hsa-miR-181b-5p NFIB 0.488256489401108 0.00105321129419701 -0.473125743246742 0.000230272053316789 miRNATAP -0.112830195352577 0.00742939681176461 NA NA NA hsa-miR-19b-3p NFIB 0.601279551368824 0.00016685097085251 -0.473125743246742 0.000230272053316789 miRNAWalker2_validate;miRNATAP -0.233278162514631 1.4187724242619e-09 NA NA NA hsa-miR-20a-5p NFIB 0.854326758727003 5.04256669663285e-07 -0.473125743246742 0.000230272053316789 mirMAP;miRNATAP -0.237769487514429 3.03499805824516e-11 NA NA NA hsa-miR-20b-5p NFIB 0.457668023910379 0.0285865211936156 -0.473125743246742 0.000230272053316789 mirMAP;miRNATAP -0.120003660508863 5.99420231425077e-05 NA NA NA hsa-miR-21-5p NFIB 1.51084295924322 1.54551622173259e-34 -0.473125743246742 0.000230272053316789 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.229349055079126 8.74417104722524e-07 NA NA NA hsa-miR-409-3p NFIB -0.499649792570937 0.0526751181520117 -0.473125743246742 0.000230272053316789 PITA;mirMAP -0.110447376472385 4.85576201237671e-06 NA NA NA hsa-miR-17-3p NFIC 0.410352776142368 0.00422200500748636 -0.577436174020039 0.00748919731318304 mirMAP -0.265314725139927 0.000297292926733514 NA NA NA hsa-miR-19b-3p NFIC 0.601279551368824 0.00016685097085251 -0.577436174020039 0.00748919731318304 miRNATAP -0.186441242876713 0.00456423560895714 NA NA NA hsa-miR-20a-5p NFIC 0.854326758727003 5.04256669663285e-07 -0.577436174020039 0.00748919731318304 miRNATAP -0.257221821315235 2.44112891586052e-05 NA NA NA hsa-miR-20b-5p NFIC 0.457668023910379 0.0285865211936156 -0.577436174020039 0.00748919731318304 miRNATAP -0.145167675981084 0.00395935579597145 NA NA NA hsa-miR-21-5p NFIC 1.51084295924322 1.54551622173259e-34 -0.577436174020039 0.00748919731318304 mirMAP -0.483685235297627 4.40025750800735e-10 NA NA NA hsa-miR-432-5p NFIC -0.536178819038888 0.0748623258271085 -0.577436174020039 0.00748919731318304 mirMAP -0.131027413874262 0.000180730589173953 NA NA NA hsa-miR-146a-5p NFIX -0.742958238440575 0.000765983177482633 -0.0507190853125827 0.707056383209184 mirMAP -0.158971080976966 4.9608788016279e-08 NA NA NA hsa-miR-146b-5p NFIX 0.419719546795449 0.0457375823220155 -0.0507190853125827 0.707056383209184 mirMAP;miRNATAP -0.116045343442919 0.000188162938479516 NA NA NA hsa-miR-409-3p NFIX -0.499649792570937 0.0526751181520117 -0.0507190853125827 0.707056383209184 PITA;mirMAP -0.138418719870169 3.26143968063146e-08 NA NA NA hsa-miR-15a-5p NFKB1 0.349521211668244 0.000770735998804736 -0.538916955748098 1.42993670239858e-08 miRNAWalker2_validate -0.153048958379264 0.000730484492411411 NA NA NA hsa-miR-27b-3p NFKBID -0.823491817819754 9.20935302746823e-14 0.15868940224537 0.380896735951309 miRNATAP -0.268247051136389 0.000555043837990117 NA NA NA hsa-miR-455-3p NFKBID -1.3998033821095 5.72010709806871e-17 0.15868940224537 0.380896735951309 miRNATAP -0.26860318469061 8.25213498965582e-08 NA NA NA hsa-miR-222-3p NFS1 1.08574156066353 1.76407192348131e-11 -0.269480145618274 0.000369277181019047 miRNAWalker2_validate -0.102943367980855 3.31544441959947e-06 NA NA NA hsa-miR-34a-5p NGFR 1.03694231790865 5.74864019540594e-14 -3.21029001367102 1.44390076140831e-24 mirMAP -0.558348892128834 8.29526099358313e-07 NA NA NA hsa-miR-214-5p NHEJ1 -1.91497809567701 3.92955595018147e-12 0.227380782980183 0.0118468096990922 miRNATAP -0.100787840213259 5.72801896682211e-11 NA NA NA hsa-miR-181a-5p NHLRC2 0.250113435902954 0.0551933249319293 -1.1330149468621 2.05949478884869e-14 mirMAP -0.128938758012222 0.0249290837800839 NA NA NA hsa-miR-181b-5p NHLRC2 0.488256489401108 0.00105321129419701 -1.1330149468621 2.05949478884869e-14 mirMAP -0.111877500292654 0.025298554329014 NA NA NA hsa-miR-19b-3p NHLRC2 0.601279551368824 0.00016685097085251 -1.1330149468621 2.05949478884869e-14 mirMAP -0.186190807178582 5.63543537575525e-05 NA NA NA hsa-miR-21-5p NHLRC2 1.51084295924322 1.54551622173259e-34 -1.1330149468621 2.05949478884869e-14 mirMAP -0.402866583052703 1.13908305342286e-13 NA NA NA hsa-miR-20a-5p NHLRC3 0.854326758727003 5.04256669663285e-07 -0.752710457579298 8.05410213066884e-14 MirTarget -0.115813820031321 7.43742321072744e-05 NA NA NA hsa-miR-148a-3p NHS -0.748702855596996 3.93313343865641e-07 0.0267805163013115 0.897730201737297 MirTarget;miRNATAP -0.58530039907232 2.38805824257e-19 NA NA NA hsa-miR-19b-3p NHS 0.601279551368824 0.00016685097085251 0.0267805163013115 0.897730201737297 miRNATAP -0.169630990277723 0.00726531356662525 NA NA NA hsa-miR-20a-5p NHS 0.854326758727003 5.04256669663285e-07 0.0267805163013115 0.897730201737297 miRNATAP -0.245126122005119 2.85188428653405e-05 NA NA NA hsa-miR-27b-3p NHS -0.823491817819754 9.20935302746823e-14 0.0267805163013115 0.897730201737297 miRNATAP -0.264461277599143 0.00314226775451808 NA NA NA hsa-miR-30e-5p NHS -0.627815042856657 3.02205690184908e-10 0.0267805163013115 0.897730201737297 MirTarget -0.274350448576664 0.00635241794024475 NA NA NA hsa-miR-29c-3p NID1 -1.4367517608807 1.61767774905781e-21 -0.446050291669521 0.00207774963654252 MirTarget -0.193988331166979 1.25321838426661e-05 NA NA NA hsa-miR-146b-5p NID2 0.419719546795449 0.0457375823220155 -0.0802964384348819 0.635707085737926 miRanda -0.149753150145886 0.000125254193140163 NA NA NA hsa-miR-192-3p NIN -0.6401165114007 0.000266272092403814 0.65727987135705 1.81289405977022e-08 mirMAP -0.187339477760466 6.23635295150076e-09 26743688 MiR 192 suppresses the tumorigenicity of prostate cancer cells by targeting and inhibiting nin one binding protein prostate cancer hsa-miR-192-5p NIN -0.50188499512787 0.00344713341196035 0.65727987135705 1.81289405977022e-08 miRNAWalker2_validate -0.161020480125805 1.320755580245e-06 26743688 MiR 192 suppresses the tumorigenicity of prostate cancer cells by targeting and inhibiting nin one binding protein prostate cancer hsa-miR-455-5p NIPAL2 -0.270546034117157 0.0581320703577731 0.373983098650203 0.11630572529975 miRanda -0.253337166407884 0.00186189979963527 NA NA NA hsa-miR-181a-5p NKAIN2 0.250113435902954 0.0551933249319293 0.282151651650571 0.496700380775914 MirTarget;miRNATAP -0.31795389128732 0.041487811875557 NA NA NA hsa-miR-181b-5p NKAIN2 0.488256489401108 0.00105321129419701 0.282151651650571 0.496700380775914 MirTarget;miRNATAP -0.328018629024826 0.0155102783136241 NA NA NA hsa-miR-20a-5p NKIRAS1 0.854326758727003 5.04256669663285e-07 -1.03217749329624 2.29315553156374e-18 MirTarget;miRNATAP -0.185857979438144 6.6889869956806e-08 NA NA NA hsa-miR-21-5p NKIRAS1 1.51084295924322 1.54551622173259e-34 -1.03217749329624 2.29315553156374e-18 MirTarget -0.463907525797565 2.32268152012086e-28 NA NA NA hsa-miR-29c-3p NKIRAS2 -1.4367517608807 1.61767774905781e-21 0.498667168432674 1.95803169770802e-13 miRNAWalker2_validate;miRNATAP -0.154763140744847 9.19046320975968e-14 NA NA NA hsa-miR-29c-3p NKTR -1.4367517608807 1.61767774905781e-21 0.473169872664043 0.000140527697400655 MirTarget;miRNATAP -0.140875886526712 0.000236152906016198 NA NA NA hsa-miR-455-5p NKX3-1 -0.270546034117157 0.0581320703577731 -2.0946554312216 1.15462076436185e-17 miRanda -0.317820712283425 0.000261949401076522 NA NA NA hsa-miR-30c-5p NLE1 -0.432111642767632 0.000159764714931007 0.691175093309583 4.19043198742371e-09 miRNAWalker2_validate -0.210482662410955 3.26751796633788e-05 NA NA NA hsa-miR-132-3p NLK 0.323796239695997 0.00272093067935091 0.22134800606754 0.00116385654486987 miRNATAP -0.128638110704715 2.68599518720146e-05 NA NA NA hsa-miR-19b-3p NLN 0.601279551368824 0.00016685097085251 -0.816592692260158 8.70031751400168e-08 mirMAP -0.216386391157484 3.48086961032493e-06 NA NA NA hsa-miR-455-5p NLRC3 -0.270546034117157 0.0581320703577731 -0.376510460971801 0.0104682481148463 miRanda -0.167092015963969 0.00089747218518082 NA NA NA hsa-miR-194-5p NMB -0.292530160992458 0.0996141384876663 1.75897686367225 1.31725530796709e-18 MirTarget -0.207443459673975 0.000283303946509133 NA NA NA hsa-miR-27b-3p NMB -0.823491817819754 9.20935302746823e-14 1.75897686367225 1.31725530796709e-18 MirTarget -0.404969560167753 5.66051455838046e-06 NA NA NA hsa-miR-181a-5p NNT 0.250113435902954 0.0551933249319293 -1.00636428911703 1.46289096561224e-10 MirTarget;mirMAP -0.396077985093936 1.76141797187394e-11 NA NA NA hsa-miR-181b-5p NNT 0.488256489401108 0.00105321129419701 -1.00636428911703 1.46289096561224e-10 MirTarget;mirMAP -0.378580519646715 1.06404373137532e-13 NA NA NA hsa-miR-409-3p NNT -0.499649792570937 0.0526751181520117 -1.00636428911703 1.46289096561224e-10 PITA -0.135084106732912 6.97845049996133e-06 NA NA NA hsa-miR-30e-5p NOL12 -0.627815042856657 3.02205690184908e-10 0.999658761112782 1.77902212379803e-23 miRNAWalker2_validate -0.342375877639529 6.78099134625428e-12 NA NA NA hsa-miR-181a-5p NOL4 0.250113435902954 0.0551933249319293 -3.34785387311656 6.2589012007234e-19 miRNAWalker2_validate;mirMAP;miRNATAP -0.428646605215613 0.00373758821084824 NA NA NA hsa-miR-181b-5p NOL4 0.488256489401108 0.00105321129419701 -3.34785387311656 6.2589012007234e-19 mirMAP;miRNATAP -0.511486834468801 6.45774136480916e-05 NA NA NA hsa-miR-20a-5p NOL4 0.854326758727003 5.04256669663285e-07 -3.34785387311656 6.2589012007234e-19 miRNATAP -0.320425074528421 0.00409282207731523 NA NA NA hsa-miR-432-5p NOL4 -0.536178819038888 0.0748623258271085 -3.34785387311656 6.2589012007234e-19 miRNATAP -0.15288978289923 0.0169474341933775 NA NA NA hsa-miR-34a-5p NOTCH1 1.03694231790865 5.74864019540594e-14 -0.0333826274090256 0.795560724559869 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.239301431096606 3.83055699888448e-08 22438124;23140286;24349627;24565525;25783790;20351093;27082152;23642368;22347519;23430952;23902763;21743299;22992310;23145211;25623761;23085450 Delta tocotrienol suppresses Notch 1 pathway by upregulating miR 34a in nonsmall cell lung cancer cells; In our study using miRNA microarray we observed that downregulation of the Notch-1 pathway by delta-tocotrienol correlated with upregulation of miR-34a in nonsmall cell lung cancer cells NSCLC;We found that Re-expression forced expression of miR-34a inhibits cell growth and induces apoptosis with concomitant down-regulation of Notch-1 signaling pathway one of the target of miR-34a; Moreover treatment of PC cells with a natural compound genistein led to the up-regulation of miR-34a resulting in the down-regulation of Notch-1 which was correlated with inhibition of cell growth and induction of apoptosis;Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed reexpression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens;In addition intracellular restoration of miR-34a inhibited breast cancer cell migration via targeting Notch-1 signaling;MicroRNA 34a suppresses the breast cancer stem cell like characteristics by downregulating Notch1 pathway; In this study we verified that miR-34a directly and functionally targeted Notch1 in MCF-7 cells; We reported that miR-34a negatively regulated cell proliferation migration and invasion and breast cancer stem cell propagation by downregulating Notch1; The expression of miR-34a was negatively correlated with tumor stages metastasis and Notch1 expression in breast cancer tissues; Furthermore overexpression of miR-34a increased chemosensitivity of breast cancer cells to paclitaxel PTX by downregulating the Notch1 pathway; Taken together our results indicate that miR-34a inhibited breast cancer stemness and increased the chemosensitivity to PTX partially by downregulating the Notch1 pathway suggesting that miR-34a/Notch1 play an important role in regulating breast cancer stem cells;MicroRNA 34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells; Computational miRNA target prediction suggested that Notch1 and Jagged1 were targets of miR-34a; By using functional assays miR-34a was demonstrated to bind to the 3' untranslated regions of Notch1 and Jagged1; Forced expression of miR-34a altered the expression of Notch1 and Jagged1 protein as well as Notch signaling as shown by the response of Hairy Enhancer of Split-1 protein to these treatments using western blot analysis;We showed that miR-34a as a tumor suppressor could separately reduce the stemness of BCSCs and activate the cytotoxic susceptibility of BCSCs to natural killer NK cells in vitro via down regulating the expression of Notch1 signaling molecules;Mechanistically miR-34a sequesters Notch1 mRNA to generate a sharp threshold response where a bimodal Notch signal specifies the choice between self-renewal and differentiation;Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed re-expression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens;We also found that reexpression of miR-34a and miR-200b by transfection led to reduced expression of Notch-1 resulting in the inhibition of osteosarcoma cell proliferation invasion and angiogenesis;Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial mesenchymal transition EMT by miR 34a mediated suppression of Notch 1 expression in non small cell lung cancer cell lines; Indeed rhamnetin and cirsiliol increased the expression of tumor-suppressive microRNA miR-34a in a p53-dependent manner leading to inhibition of Notch-1 expression;MicroRNA 34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme; Also we identified notch1 as a direct target gene of miR-34a; Knockdown of notch1 showed similar cellular functions as overexpression of miR-34a both in vitro and in vivo; Collectively our findings show that miR-34a is downregulated in GBM cells and inhibits GBM growth by targeting notch1;The re-expression of miR-34 led to a marked reduction in the expression of its target gene Notch-1;Inactivation of AR and Notch 1 signaling by miR 34a attenuates prostate cancer aggressiveness; We found that over-expression of miR-34a led to reduced expression of AR PSA and Notch-1; These findings suggest that the loss of miR-34a is directly linked with up-regulation of AR and Notch-1 both of which are highly expressed in PCa and thus finding innovative approaches by which miR-34a expression could be up-regulated will have a huge impact on the treatment of PCa especially for the treatment of mCRPC;miR 34a may regulate sensitivity of breast cancer cells to adriamycin via targeting Notch1; To explore the influence of miR-34a on Notch1 expression in breast cancer cells and to explore the role of miR-34a in the sensitivity of breast cancer cells to Adriamycin ADR; The expression levels of Notch1 mRNA and protein in MCF-7/ADR cells transfected with miR-34a mimics were significantly up-regulated; On the contrary the expressions of Notch1 mRNA and protein in MCF-7 cells transfected with miR-34a inhibitor were down-regulated; miR-34a negatively regulates the expression of Notch1 at both mRNA and protein levels;MicroRNA 34a modulates chemosensitivity of breast cancer cells to adriamycin by targeting Notch1; The association of miR-34a and Notch1 was analyzed by dual-luciferase reporter assay and Notch1-siRNA technology; Real-time PCR assay was performed to test the expression of miR-34a and Notch1 in 38 selective breast cancer tissue samples; MiR-34a mimic could inhibit the luciferase activity of the construct containing wild-type 3' UTR of Notch1 in MCF-7/ADR cells; Further there was an inverse association between Notch1 and miR-34a expression in breast cancer; Dysregulation of miR-34a plays critical roles in the acquired ADR resistance of breast cancer at least in part via targeting Notch1 ;;;cell migration;staging;metastasis;drug resistance;;differentiation;drug resistance;;;;;;;;drug resistance lung squamous cell cancer;pancreatic cancer;prostate cancer;breast cancer;breast cancer;cervical and endocervical cancer;breast cancer;colon cancer;prostate cancer;sarcoma;lung squamous cell cancer;glioblastoma;colon cancer;prostate cancer;breast cancer;breast cancer hsa-miR-146b-5p NOTCH2 0.419719546795449 0.0457375823220155 -0.382079512558875 0.00411077346024402 miRanda -0.13767547742131 7.26853497786302e-06 NA NA NA hsa-miR-15a-5p NOTCH2 0.349521211668244 0.000770735998804736 -0.382079512558875 0.00411077346024402 MirTarget -0.211011609000242 0.000764396919128515 NA NA NA hsa-miR-34a-5p NOTCH2 1.03694231790865 5.74864019540594e-14 -0.382079512558875 0.00411077346024402 miRNAWalker2_validate;miRNATAP -0.209801751186156 3.89799565892934e-06 NA NA NA hsa-miR-455-5p NOTCH2 -0.270546034117157 0.0581320703577731 -0.382079512558875 0.00411077346024402 miRanda -0.109772030304636 0.0163620331180249 NA NA NA hsa-miR-30e-5p NOTCH2NL -0.627815042856657 3.02205690184908e-10 0.00358194574453119 0.981228187269236 mirMAP -0.193089865355544 0.00853812224990979 NA NA NA hsa-miR-30e-5p NOV -0.627815042856657 3.02205690184908e-10 0.672591505505637 0.00289608619086141 MirTarget -0.395919520498491 0.000287094895171899 NA NA NA hsa-miR-146b-5p NOVA1 0.419719546795449 0.0457375823220155 -0.237953091882935 0.490244872279506 PITA;miRanda;miRNATAP -0.200678876499541 0.0120536146041457 26673617 NOVA1 inhibition by miR 146b 5p in the remnant tissue microenvironment defines occult residual disease after gastric cancer removal; NOVA1 a target gene of miR-146b-5p was decreased in remnant tissues of patients with a poor prognosis; In vitro analysis showed that the NOVA1 gene was inhibited by miR-146b-5p; In immune cells as well as stromal spindle cells decreased NOVA1 possibly inhibited by miR-146b-5p is a candidate biomarker predicting poor prognosis of gastric cancer patients and is also a biomarker of occult residual disease in remnant tissues after gastric cancer removal worse prognosis gastric cancer hsa-miR-148a-3p NOVA1 -0.748702855596996 3.93313343865641e-07 -0.237953091882935 0.490244872279506 miRNATAP -0.784526571402052 8.59261064718394e-13 NA NA NA hsa-miR-27b-3p NOVA1 -0.823491817819754 9.20935302746823e-14 -0.237953091882935 0.490244872279506 miRNATAP -0.449530647378964 0.00243571143594966 NA NA NA hsa-miR-455-3p NOVA1 -1.3998033821095 5.72010709806871e-17 -0.237953091882935 0.490244872279506 MirTarget;PITA;miRNATAP -0.493756895944169 2.39929969932495e-07 NA NA NA hsa-miR-455-3p NOVA2 -1.3998033821095 5.72010709806871e-17 0.996708200639387 1.91065340241348e-13 mirMAP -0.165543276647991 2.08764080032407e-05 NA NA NA hsa-miR-99a-5p NOX4 -1.51481656384839 3.93230057259529e-14 2.85543175218989 1.84008744683765e-40 MirTarget;miRNATAP -0.369339656395231 1.38010061840036e-11 26986073 MiR 99a regulates ROS mediated invasion and migration of lung adenocarcinoma cells by targeting NOX4; We then identified NOX4 as a target gene of miR-99a and NOX4 mediated the inhibition of invasion and migration of lung adenocarcinoma cells by miR-99a; Immunohistochemical staining analysis of the mouse tumor tissues revealed that NOX4 levels were downregulated in the miR-99a treatment group confirming the in vitro data of NOX4 as a direct target gene of miR-99a; Taken together these data indicate for the first time that miR-99a directly regulates the invasion and migration in lung adenocarcinoma by targeting NOX4 and that overexpression of miR-99a may become a therapeutic strategy for lung adenocarcinoma lung cancer hsa-miR-148a-3p NPEPL1 -0.748702855596996 3.93313343865641e-07 1.0134980247578 2.1959859851927e-21 MirTarget -0.275426794015186 8.58260763868164e-15 NA NA NA hsa-miR-27b-3p NPEPPS -0.823491817819754 9.20935302746823e-14 0.261825419108992 0.00402637895532677 miRNAWalker2_validate;MirTarget -0.18267052964986 2.59424625961267e-06 NA NA NA hsa-miR-17-3p NPL 0.410352776142368 0.00422200500748636 -0.120135284431252 0.54362806859635 miRNATAP -0.140002417383454 0.0373738982134236 NA NA NA hsa-miR-29c-3p NPLOC4 -1.4367517608807 1.61767774905781e-21 0.845631975356786 1.12914723995965e-25 mirMAP -0.116314732277807 8.59085754873361e-06 NA NA NA hsa-miR-99a-5p NPM3 -1.51481656384839 3.93230057259529e-14 0.673858371855758 0.000159639883324279 miRNAWalker2_validate -0.177279801325625 2.52390748975012e-05 NA NA NA hsa-miR-192-5p NPNT -0.50188499512787 0.00344713341196035 0.531754123141975 0.0583025915811082 miRNAWalker2_validate -0.467076031724044 2.50656825736623e-09 NA NA NA hsa-miR-146b-5p NPR3 0.419719546795449 0.0457375823220155 -1.42920372769258 1.19506405595807e-05 miRanda;miRNATAP -0.327769633550671 1.58431207338603e-05 NA NA NA hsa-miR-19b-3p NPR3 0.601279551368824 0.00016685097085251 -1.42920372769258 1.19506405595807e-05 mirMAP -0.624941850720006 1.97998899393592e-10 NA NA NA hsa-miR-148a-3p NPTX1 -0.748702855596996 3.93313343865641e-07 0.929025880461533 0.00584289763512414 miRNATAP -1.16655047743286 9.17100827578766e-30 NA NA NA hsa-miR-19b-3p NPTX1 0.601279551368824 0.00016685097085251 0.929025880461533 0.00584289763512414 mirMAP -0.253721895488485 0.0135834636679236 NA NA NA hsa-miR-20a-5p NPTX1 0.854326758727003 5.04256669663285e-07 0.929025880461533 0.00584289763512414 mirMAP -0.27668254450585 0.00385588968114642 NA NA NA hsa-miR-27b-3p NPTX1 -0.823491817819754 9.20935302746823e-14 0.929025880461533 0.00584289763512414 mirMAP -0.427830906679308 0.00329514659906769 NA NA NA hsa-miR-29c-3p NPTX1 -1.4367517608807 1.61767774905781e-21 0.929025880461533 0.00584289763512414 mirMAP -0.29739398739434 0.00425117619323195 NA NA NA hsa-miR-192-3p NPTXR -0.6401165114007 0.000266272092403814 -0.560890830244132 0.0974541871007386 mirMAP -0.554590214053961 1.61255875134486e-09 NA NA NA hsa-miR-192-5p NPTXR -0.50188499512787 0.00344713341196035 -0.560890830244132 0.0974541871007386 miRNAWalker2_validate -0.558598861403254 3.29441205098301e-09 NA NA NA hsa-miR-19b-3p NPTXR 0.601279551368824 0.00016685097085251 -0.560890830244132 0.0974541871007386 mirMAP -0.271454913358816 0.00832297818500501 NA NA NA hsa-miR-20a-5p NPTXR 0.854326758727003 5.04256669663285e-07 -0.560890830244132 0.0974541871007386 mirMAP -0.316277236819742 0.00095246636309681 NA NA NA hsa-miR-132-3p NR1D2 0.323796239695997 0.00272093067935091 -0.431324257008006 4.19730114867347e-05 miRNAWalker2_validate -0.206198767859439 1.54184662954813e-05 NA NA NA hsa-miR-181a-5p NR1D2 0.250113435902954 0.0551933249319293 -0.431324257008006 4.19730114867347e-05 miRNATAP -0.186345856197712 2.23891254598488e-06 NA NA NA hsa-miR-181b-5p NR1D2 0.488256489401108 0.00105321129419701 -0.431324257008006 4.19730114867347e-05 miRNATAP -0.185985364652182 4.99649745975419e-08 NA NA NA hsa-miR-148a-3p NR2C2AP -0.748702855596996 3.93313343865641e-07 1.32716879157984 4.32641725625968e-31 MirTarget -0.218700998017347 3.7715743430841e-08 NA NA NA hsa-miR-17-3p NR3C1 0.410352776142368 0.00422200500748636 -0.4313634018742 3.79689238088369e-06 miRNATAP -0.160279582450076 3.9980164995748e-07 NA NA NA hsa-miR-181a-5p NR3C1 0.250113435902954 0.0551933249319293 -0.4313634018742 3.79689238088369e-06 miRNATAP -0.224644123269224 8.10929241794079e-11 NA NA NA hsa-miR-181b-5p NR3C1 0.488256489401108 0.00105321129419701 -0.4313634018742 3.79689238088369e-06 mirMAP;miRNATAP -0.22908968686461 1.4146603968692e-14 NA NA NA hsa-miR-19b-3p NR3C1 0.601279551368824 0.00016685097085251 -0.4313634018742 3.79689238088369e-06 miRNAWalker2_validate -0.14746616405018 1.75089801018747e-07 NA NA NA hsa-miR-19b-3p NR3C2 0.601279551368824 0.00016685097085251 -1.75071237386377 1.19472080156654e-18 miRNAWalker2_validate -0.249759488328082 6.83019464368642e-05 NA NA NA hsa-miR-409-3p NR3C2 -0.499649792570937 0.0526751181520117 -1.75071237386377 1.19472080156654e-18 PITA -0.119060619387302 0.0023349061571951 NA NA NA hsa-miR-455-5p NR4A2 -0.270546034117157 0.0581320703577731 -2.31314700292971 8.68869977700057e-19 PITA;miRanda -0.364627678712597 9.0347316704086e-05 NA NA NA hsa-miR-181a-5p NR6A1 0.250113435902954 0.0551933249319293 1.08256390882413 4.4003513734213e-08 miRNAWalker2_validate;miRNATAP -0.155632900439005 0.0394197420257092 NA NA NA hsa-miR-30b-5p NR6A1 -0.54056186708617 2.44688760798341e-05 1.08256390882413 4.4003513734213e-08 mirMAP -0.236980274040195 0.00183574142247836 NA NA NA hsa-miR-148a-3p NRARP -0.748702855596996 3.93313343865641e-07 0.806873954048561 5.97890763868229e-07 MirTarget -0.408607463172978 2.94880871586574e-15 NA NA NA hsa-miR-29c-3p NRAS -1.4367517608807 1.61767774905781e-21 0.301156333096785 0.000285671613438218 miRNATAP -0.195416271463693 3.04370398757482e-15 NA NA NA hsa-miR-29c-3p NRBP1 -1.4367517608807 1.61767774905781e-21 0.26396663832335 0.000177471192913107 miRNATAP -0.150035034494036 1.21983928378936e-12 NA NA NA hsa-miR-30b-5p NRBP1 -0.54056186708617 2.44688760798341e-05 0.26396663832335 0.000177471192913107 MirTarget -0.108383328098971 4.43012054503486e-05 NA NA NA hsa-miR-30e-5p NRBP1 -0.627815042856657 3.02205690184908e-10 0.26396663832335 0.000177471192913107 MirTarget -0.130377208201441 0.000119006856400977 NA NA NA hsa-miR-221-3p NRG1 1.12244756358612 3.48370308238012e-13 -3.95953255287574 8.76353628841238e-16 miRNATAP -1.23477474002632 3.94326582819637e-16 NA NA NA hsa-miR-222-3p NRG1 1.08574156066353 1.76407192348131e-11 -3.95953255287574 8.76353628841238e-16 miRNATAP -1.04996571628849 8.66931217534908e-13 NA NA NA hsa-miR-455-5p NRG1 -0.270546034117157 0.0581320703577731 -3.95953255287574 8.76353628841238e-16 miRanda -0.613382593210354 0.000436853318971772 NA NA NA hsa-miR-17-3p NRIP1 0.410352776142368 0.00422200500748636 -0.82531109781187 2.66112725361499e-13 MirTarget -0.173157016844953 9.88064869896386e-06 NA NA NA hsa-miR-148a-3p NRP1 -0.748702855596996 3.93313343865641e-07 -0.0892756788072155 0.498410902584577 miRNATAP -0.18925467975584 9.1215690162959e-06 26967387 Mechanistically miR-148a appears to suppress the extravasation process of cancer cells likely by targeting two genes WNT1 and NRP1 in a cell non-autonomous manner breast cancer hsa-miR-194-5p NRP1 -0.292530160992458 0.0996141384876663 -0.0892756788072155 0.498410902584577 miRNATAP -0.269035682601714 1.61605325817804e-14 NA NA NA hsa-miR-192-3p NRP2 -0.6401165114007 0.000266272092403814 -0.674856646653151 5.65037785901106e-05 mirMAP -0.367841752094888 3.12974788568996e-16 NA NA NA hsa-miR-27b-3p NSD1 -0.823491817819754 9.20935302746823e-14 0.62757997714685 2.58183062912293e-14 miRNATAP -0.109422770536978 0.00269941190094211 NA NA NA hsa-miR-29c-3p NSD1 -1.4367517608807 1.61767774905781e-21 0.62757997714685 2.58183062912293e-14 MirTarget;miRNATAP -0.130042640648096 4.6510403991265e-07 NA NA NA hsa-miR-455-3p NT5DC2 -1.3998033821095 5.72010709806871e-17 2.16871503598175 2.70972887150847e-20 miRNAWalker2_validate -0.220885105363023 0.00138951586852671 NA NA NA hsa-miR-30c-5p NT5E -0.432111642767632 0.000159764714931007 -1.22090773788306 8.8702357666604e-10 miRNATAP -0.194331439593249 0.0250925312313473 NA NA NA hsa-miR-34a-5p NT5E 1.03694231790865 5.74864019540594e-14 -1.22090773788306 8.8702357666604e-10 miRNAWalker2_validate -0.192356981917961 0.00587873964838024 NA NA NA hsa-miR-21-5p NTF3 1.51084295924322 1.54551622173259e-34 -3.97962534066229 2.44784627289438e-41 miRTarBase;miRNATAP -1.02982933864977 2.33503442659123e-19 NA NA NA hsa-miR-221-3p NTF3 1.12244756358612 3.48370308238012e-13 -3.97962534066229 2.44784627289438e-41 miRNATAP -0.487132834663555 1.03773554125066e-06 NA NA NA hsa-miR-222-3p NTF3 1.08574156066353 1.76407192348131e-11 -3.97962534066229 2.44784627289438e-41 miRNATAP -0.44960074696525 2.69176815020579e-06 NA NA NA hsa-miR-122-3p NTM -1.75369011054591 1.52070648599898e-11 1.33853224720958 0.000643118047043159 miRNATAP -0.595092010865499 9.60921036628071e-18 NA NA NA hsa-miR-20a-5p NTN4 0.854326758727003 5.04256669663285e-07 -1.69514452471032 1.94972293728933e-19 MirTarget;miRNATAP -0.562725693111189 5.9049386822628e-27 NA NA NA hsa-miR-20b-5p NTN4 0.457668023910379 0.0285865211936156 -1.69514452471032 1.94972293728933e-19 MirTarget;miRNATAP -0.156126013708269 0.000638162428975642 NA NA NA hsa-miR-146b-5p NTRK2 0.419719546795449 0.0457375823220155 -2.30467079336051 6.66762032408277e-09 PITA;miRanda -0.211307147584135 0.0245992788491132 NA NA NA hsa-miR-17-3p NTRK2 0.410352776142368 0.00422200500748636 -2.30467079336051 6.66762032408277e-09 miRNATAP -0.453219975208752 0.000970000263503074 NA NA NA hsa-miR-21-5p NTRK2 1.51084295924322 1.54551622173259e-34 -2.30467079336051 6.66762032408277e-09 mirMAP -0.307805996175828 0.0376038333861936 NA NA NA hsa-miR-224-3p NTRK2 1.40770116795301 1.31426607144612e-08 -2.30467079336051 6.66762032408277e-09 mirMAP -0.174340903906123 0.0281465723728938 NA NA NA hsa-miR-455-3p NTRK2 -1.3998033821095 5.72010709806871e-17 -2.30467079336051 6.66762032408277e-09 mirMAP -0.236935148889472 0.0374236181020148 NA NA NA hsa-miR-30b-5p NUAK1 -0.54056186708617 2.44688760798341e-05 0.794259973271986 6.86027622473925e-11 miRNATAP -0.129287684890741 0.00612374561402766 NA NA NA hsa-miR-20a-5p NUBPL 0.854326758727003 5.04256669663285e-07 -0.487181955870277 0.000338824031290841 mirMAP -0.193617400121834 4.24127360189023e-07 NA NA NA hsa-miR-20b-5p NUBPL 0.457668023910379 0.0285865211936156 -0.487181955870277 0.000338824031290841 mirMAP -0.134429607573096 2.10415699996219e-05 NA NA NA hsa-miR-21-5p NUBPL 1.51084295924322 1.54551622173259e-34 -0.487181955870277 0.000338824031290841 miRNAWalker2_validate -0.390836294612581 4.75661868182593e-16 NA NA NA hsa-miR-181a-5p NUDT12 0.250113435902954 0.0551933249319293 -0.913123810950026 1.69707017169193e-05 miRNAWalker2_validate -0.562330871911008 7.05073839834535e-13 NA NA NA hsa-miR-182-5p NUDT13 1.96601340710222 4.39326175603633e-09 -0.432082929084188 0.0143058788336358 miRNATAP -0.108899382711946 1.32984777944085e-05 NA NA NA hsa-miR-21-5p NUDT16 1.51084295924322 1.54551622173259e-34 -0.306472623503673 0.00173007556301039 mirMAP -0.195353647088521 2.96129833416772e-08 NA NA NA hsa-miR-127-3p NUDT7 -1.0751374948053 2.19322892330221e-05 -0.838346290126138 2.28770793563735e-07 miRanda -0.104545448231986 0.000810310280343762 NA NA NA hsa-miR-215-5p NUF2 -0.981544773246509 3.14452272477156e-05 4.67230101715264 5.60994581439997e-55 miRNAWalker2_validate -0.208962705532909 0.00292659274785858 NA NA NA hsa-miR-29c-3p NUP160 -1.4367517608807 1.61767774905781e-21 0.0580476104598864 0.515008533495551 MirTarget;miRNATAP -0.142638108369321 1.21850205848045e-07 NA NA NA hsa-miR-15a-5p NUP50 0.349521211668244 0.000770735998804736 -0.154667224043349 0.0509712309246497 miRNATAP -0.114374926962987 0.00205904628456073 NA NA NA hsa-miR-30c-5p NUP93 -0.432111642767632 0.000159764714931007 0.683301866755991 5.39935317923476e-15 MirTarget -0.105754013598471 0.00587800299394249 NA NA NA hsa-miR-30e-5p NUP93 -0.627815042856657 3.02205690184908e-10 0.683301866755991 5.39935317923476e-15 MirTarget -0.269813238660382 2.70458417337784e-10 NA NA NA hsa-miR-181a-5p NUS1 0.250113435902954 0.0551933249319293 -0.427303709834115 2.28636311182502e-08 MirTarget;mirMAP -0.116435261204726 5.50666747229246e-05 NA NA NA hsa-miR-455-5p OAS2 -0.270546034117157 0.0581320703577731 -0.819893707243843 0.000143362233843533 miRanda -0.219235689146956 0.00316617805105624 NA NA NA hsa-miR-222-3p OAZ2 1.08574156066353 1.76407192348131e-11 -0.344754669275794 6.55566204103316e-07 miRNAWalker2_validate -0.138992526742212 4.48922571256697e-12 NA NA NA hsa-miR-148a-3p OBSCN -0.748702855596996 3.93313343865641e-07 0.486867072596689 0.143711952566939 mirMAP -0.963676081304784 1.74328515884929e-20 NA NA NA hsa-miR-181a-5p OCIAD1 0.250113435902954 0.0551933249319293 -0.363945364154922 2.88737977727414e-07 MirTarget -0.106238406107376 6.86328078875015e-05 NA NA NA hsa-miR-181b-5p OCIAD1 0.488256489401108 0.00105321129419701 -0.363945364154922 2.88737977727414e-07 MirTarget -0.106340014094103 4.32148383508894e-06 NA NA NA hsa-miR-455-5p ODF2L -0.270546034117157 0.0581320703577731 -0.246569531898302 0.21402070783807 miRanda -0.41710273000532 3.80484653803639e-10 NA NA NA hsa-miR-192-5p OGFRL1 -0.50188499512787 0.00344713341196035 -0.0390871680110974 0.773149067173146 miRNAWalker2_validate -0.281905869784042 3.56744239803102e-14 NA NA NA hsa-miR-146b-5p OGN 0.419719546795449 0.0457375823220155 -1.55982376576111 0.000506867967825776 miRanda -0.232588059069955 0.0264463747718233 NA NA NA hsa-miR-29c-3p OIP5 -1.4367517608807 1.61767774905781e-21 2.94467357918934 2.50419782910699e-34 miRNAWalker2_validate -0.959138415167226 6.28043813456914e-39 NA NA NA hsa-miR-27b-3p OLA1 -0.823491817819754 9.20935302746823e-14 0.52316411098601 2.99376745478249e-10 mirMAP -0.100559995408859 0.00574171838670775 NA NA NA hsa-miR-146b-5p OLFM1 0.419719546795449 0.0457375823220155 -2.165579921676 6.7701870263171e-13 miRanda -0.172604787948697 0.0165539023349427 NA NA NA hsa-miR-17-3p OLFM1 0.410352776142368 0.00422200500748636 -2.165579921676 6.7701870263171e-13 miRNATAP -0.361277330380532 0.000596721835870348 NA NA NA hsa-miR-34a-5p OLFML1 1.03694231790865 5.74864019540594e-14 -0.938453928888915 6.48694963061488e-05 MirTarget -0.175964341031667 0.0307949616904958 NA NA NA hsa-miR-455-3p OLFML2A -1.3998033821095 5.72010709806871e-17 2.22497603418815 1.75452564698925e-28 mirMAP -0.411408147791361 3.13107560970885e-12 NA NA NA hsa-miR-505-5p OLFML2A -0.768282569967001 1.14662846595407e-05 2.22497603418815 1.75452564698925e-28 mirMAP -0.197944606718761 0.000851386373226674 NA NA NA hsa-miR-30b-5p OLFML2B -0.54056186708617 2.44688760798341e-05 2.97101469614559 1.92073418418798e-42 miRNAWalker2_validate -0.229947660775389 0.0121850849842124 NA NA NA hsa-miR-181a-5p ONECUT2 0.250113435902954 0.0551933249319293 0.120890541524141 0.551384233388767 miRNATAP -0.411975786149004 3.9818898992316e-08 NA NA NA hsa-miR-181b-5p ONECUT2 0.488256489401108 0.00105321129419701 0.120890541524141 0.551384233388767 miRNATAP -0.39813190440824 8.91061008627239e-10 NA NA NA hsa-miR-30b-5p ONECUT2 -0.54056186708617 2.44688760798341e-05 0.120890541524141 0.551384233388767 mirMAP -0.210012545636341 0.00624525668903263 NA NA NA hsa-miR-455-5p OPHN1 -0.270546034117157 0.0581320703577731 0.532607187807659 0.00456117838675496 miRanda -0.373616110530078 3.87590646625606e-09 NA NA NA hsa-miR-455-5p OPN3 -0.270546034117157 0.0581320703577731 0.605073571980075 7.59189180325343e-05 miRanda -0.219600968710051 2.77939891896753e-05 NA NA NA hsa-miR-148a-3p ORAI2 -0.748702855596996 3.93313343865641e-07 0.147939436354318 0.336648923993268 mirMAP -0.628934430358564 3.04155769826223e-44 NA NA NA hsa-miR-192-5p ORAI2 -0.50188499512787 0.00344713341196035 0.147939436354318 0.336648923993268 mirMAP -0.542034181754501 1.59692192661204e-43 NA NA NA hsa-miR-27b-3p ORAI2 -0.823491817819754 9.20935302746823e-14 0.147939436354318 0.336648923993268 mirMAP -0.191637385984906 0.00377868186094634 NA NA NA hsa-miR-29c-3p ORAI2 -1.4367517608807 1.61767774905781e-21 0.147939436354318 0.336648923993268 mirMAP -0.100172194500516 0.0344965605872658 NA NA NA hsa-miR-455-3p ORAI2 -1.3998033821095 5.72010709806871e-17 0.147939436354318 0.336648923993268 mirMAP -0.246334736777742 6.54404658731731e-09 NA NA NA hsa-miR-455-5p ORAI2 -0.270546034117157 0.0581320703577731 0.147939436354318 0.336648923993268 mirMAP -0.184953621229972 0.000422813184478854 NA NA NA hsa-miR-20b-5p ORMDL3 0.457668023910379 0.0285865211936156 -0.586540806595568 3.16554240885597e-06 MirTarget;miRNATAP -0.109330828072015 0.00020879336733033 NA NA NA hsa-miR-192-5p OSBPL10 -0.50188499512787 0.00344713341196035 -0.476374175815799 0.0254876734402078 miRNAWalker2_validate -0.484281305155656 1.07042567892179e-16 NA NA NA hsa-miR-30e-5p OSBPL10 -0.627815042856657 3.02205690184908e-10 -0.476374175815799 0.0254876734402078 mirMAP -0.412694620210373 5.82109015485493e-05 NA NA NA hsa-miR-455-3p OSBPL10 -1.3998033821095 5.72010709806871e-17 -0.476374175815799 0.0254876734402078 mirMAP -0.283527522642784 1.78955347509166e-06 NA NA NA hsa-miR-132-3p OSBPL11 0.323796239695997 0.00272093067935091 -0.799904171828814 5.51246180930698e-12 miRNATAP -0.179323248702279 0.000863146090517031 NA NA NA hsa-miR-17-3p OSBPL11 0.410352776142368 0.00422200500748636 -0.799904171828814 5.51246180930698e-12 MirTarget -0.158778155026616 7.95286242255601e-05 NA NA NA hsa-miR-181a-5p OSBPL11 0.250113435902954 0.0551933249319293 -0.799904171828814 5.51246180930698e-12 mirMAP -0.164752434075649 0.000211877433748934 NA NA NA hsa-miR-181b-5p OSBPL11 0.488256489401108 0.00105321129419701 -0.799904171828814 5.51246180930698e-12 mirMAP -0.181956901057965 2.27267984348015e-06 NA NA NA hsa-miR-19b-3p OSBPL11 0.601279551368824 0.00016685097085251 -0.799904171828814 5.51246180930698e-12 MirTarget -0.125804407263697 0.000480237620660196 NA NA NA hsa-miR-21-5p OSBPL1A 1.51084295924322 1.54551622173259e-34 -0.743477471816192 2.63416935352607e-06 miRNAWalker2_validate -0.155153775737544 0.0078788472837604 NA NA NA hsa-miR-20a-5p OSBPL5 0.854326758727003 5.04256669663285e-07 -0.232687135902777 0.200278988219421 miRNATAP -0.172938092478945 0.000747897043301927 NA NA NA hsa-miR-21-5p OSBPL6 1.51084295924322 1.54551622173259e-34 -0.977274624507167 6.64307851482683e-05 mirMAP -0.344549480682748 0.00012294985070846 NA NA NA hsa-miR-146b-5p OSBPL9 0.419719546795449 0.0457375823220155 -0.463319524685029 2.85724233917132e-05 miRanda -0.111863960088596 1.30076188781608e-05 NA NA NA hsa-miR-30e-5p OSGIN2 -0.627815042856657 3.02205690184908e-10 -0.155101196476452 0.18350102938637 mirMAP -0.174260668842738 0.00190995369560243 NA NA NA hsa-miR-20a-5p OSR1 0.854326758727003 5.04256669663285e-07 0.85668860217344 0.00884127717216095 MirTarget;miRNATAP -0.448880355184299 1.08383075736431e-06 NA NA NA hsa-miR-20b-5p OSR1 0.457668023910379 0.0285865211936156 0.85668860217344 0.00884127717216095 MirTarget;miRNATAP -0.195922549076559 0.0103835192083689 NA NA NA hsa-miR-194-5p OSTM1 -0.292530160992458 0.0996141384876663 -0.0118349071088613 0.908633127122421 MirTarget -0.143836648622925 2.4901508090314e-07 NA NA NA hsa-miR-21-5p OTUD1 1.51084295924322 1.54551622173259e-34 -0.719143389849849 2.30062508510608e-14 miRNAWalker2_validate -0.218830236552547 2.98514655251898e-10 NA NA NA hsa-miR-192-5p OTUD3 -0.50188499512787 0.00344713341196035 0.701071239885856 4.04593404284281e-08 miRNAWalker2_validate -0.121855348182671 0.000889895702798122 NA NA NA hsa-miR-194-5p OTUD3 -0.292530160992458 0.0996141384876663 0.701071239885856 4.04593404284281e-08 mirMAP -0.136740504695233 0.000114741246600321 NA NA NA hsa-miR-15a-5p OTUD4 0.349521211668244 0.000770735998804736 -0.781147538845887 2.89406618341624e-12 miRNATAP -0.14310803708841 0.00810875149124944 NA NA NA hsa-miR-17-3p OTUD4 0.410352776142368 0.00422200500748636 -0.781147538845887 2.89406618341624e-12 miRNATAP -0.209566642642452 5.15102728377353e-08 NA NA NA hsa-miR-181a-5p OTUD4 0.250113435902954 0.0551933249319293 -0.781147538845887 2.89406618341624e-12 miRNATAP -0.116475601912424 0.00682230752147198 NA NA NA hsa-miR-181b-5p OTUD4 0.488256489401108 0.00105321129419701 -0.781147538845887 2.89406618341624e-12 mirMAP;miRNATAP -0.12119326423328 0.0011858364532463 NA NA NA hsa-miR-19b-3p OTUD4 0.601279551368824 0.00016685097085251 -0.781147538845887 2.89406618341624e-12 miRNAWalker2_validate -0.139324882251399 5.83761506202483e-05 NA NA NA hsa-miR-20a-5p OTUD4 0.854326758727003 5.04256669663285e-07 -0.781147538845887 2.89406618341624e-12 miRNATAP -0.171495159155073 9.09646779950092e-08 NA NA NA hsa-miR-21-5p OTUD4 1.51084295924322 1.54551622173259e-34 -0.781147538845887 2.89406618341624e-12 mirMAP -0.2461519497621 2.22000817829873e-09 NA NA NA hsa-miR-30c-5p OTUD6B -0.432111642767632 0.000159764714931007 0.720488164691301 4.05780168803687e-11 MirTarget -0.1385314121027 0.00353693314798609 NA NA NA hsa-miR-30e-5p OTUD6B -0.627815042856657 3.02205690184908e-10 0.720488164691301 4.05780168803687e-11 MirTarget -0.119482953443228 0.0269155335179681 NA NA NA hsa-miR-148a-3p OTX1 -0.748702855596996 3.93313343865641e-07 3.02229789234294 1.88083127727288e-19 miRNATAP -0.710081313126758 2.7674669266848e-10 NA NA NA hsa-miR-455-5p OTX1 -0.270546034117157 0.0581320703577731 3.02229789234294 1.88083127727288e-19 miRanda -0.333914412007302 0.00546169725377917 NA NA NA hsa-miR-20b-5p OXR1 0.457668023910379 0.0285865211936156 -0.236948422851376 0.0550505793224436 MirTarget;miRNATAP -0.137480951371199 1.35460632389355e-06 NA NA NA hsa-miR-29c-3p OXTR -1.4367517608807 1.61767774905781e-21 0.808924093526337 0.00174396860147485 miRNATAP -0.25383793596229 0.00145641278329754 NA NA NA hsa-miR-455-5p P2RY6 -0.270546034117157 0.0581320703577731 0.158911921906215 0.502227574381671 miRanda -0.41040174917552 2.98007230280234e-07 NA NA NA hsa-miR-30e-5p P4HA1 -0.627815042856657 3.02205690184908e-10 -0.764719862708628 0.000104051413632472 mirMAP -0.223113796962311 0.0201667288087096 NA NA NA hsa-miR-30c-5p P4HA2 -0.432111642767632 0.000159764714931007 1.28443986350754 2.47987914950334e-16 MirTarget;miRNATAP -0.326603743104138 1.97773104804779e-06 NA NA NA hsa-miR-30e-5p P4HA2 -0.627815042856657 3.02205690184908e-10 1.28443986350754 2.47987914950334e-16 MirTarget -0.564879848414925 1.48263396477079e-13 NA NA NA hsa-miR-455-5p PABPC4L -0.270546034117157 0.0581320703577731 1.27596977567225 8.30822407761245e-12 miRanda -0.165738128371665 0.0115771126581133 NA NA NA hsa-miR-132-3p PACRG 0.323796239695997 0.00272093067935091 -1.70413035437494 7.21588441052533e-07 MirTarget -0.665929074952664 2.23324676901242e-05 NA NA NA hsa-miR-148a-3p PACS2 -0.748702855596996 3.93313343865641e-07 0.778484820044494 1.37066720672879e-21 mirMAP -0.232363228345673 5.01661787042785e-18 NA NA NA hsa-miR-455-3p PACS2 -1.3998033821095 5.72010709806871e-17 0.778484820044494 1.37066720672879e-21 mirMAP -0.140594665466279 2.57239478410519e-09 NA NA NA hsa-miR-15a-5p PAFAH1B1 0.349521211668244 0.000770735998804736 -0.434065106493069 1.93053961424578e-10 MirTarget;miRNATAP -0.132414185465547 4.45853238359289e-05 NA NA NA hsa-miR-20a-5p PAFAH1B1 0.854326758727003 5.04256669663285e-07 -0.434065106493069 1.93053961424578e-10 MirTarget;miRNATAP -0.13262019175507 4.32224535325188e-12 NA NA NA hsa-miR-15a-5p PAFAH1B2 0.349521211668244 0.000770735998804736 -0.49682050496285 0.00261299670984924 MirTarget;miRNATAP -0.314799885317578 4.95937982980277e-05 NA NA NA hsa-miR-20a-5p PAFAH1B2 0.854326758727003 5.04256669663285e-07 -0.49682050496285 0.00261299670984924 MirTarget;miRNATAP -0.198399147598427 2.07666220081291e-05 NA NA NA hsa-miR-221-3p PAFAH1B2 1.12244756358612 3.48370308238012e-13 -0.49682050496285 0.00261299670984924 MirTarget -0.143740707434348 0.00473106063053187 NA NA NA hsa-miR-30b-5p PAFAH1B2 -0.54056186708617 2.44688760798341e-05 -0.49682050496285 0.00261299670984924 MirTarget -0.17978821046347 0.00415665431129414 NA NA NA hsa-miR-34a-5p PAFAH1B2 1.03694231790865 5.74864019540594e-14 -0.49682050496285 0.00261299670984924 miRNATAP -0.143926802018501 0.0114349757115938 NA NA NA hsa-miR-455-5p PAFAH1B2 -0.270546034117157 0.0581320703577731 -0.49682050496285 0.00261299670984924 miRanda -0.253432893825748 6.65105717745655e-06 NA NA NA hsa-miR-148a-3p PAG1 -0.748702855596996 3.93313343865641e-07 -0.0641776217701535 0.737132600565642 MirTarget -0.299690578625903 1.21889656248684e-06 NA NA NA hsa-miR-455-5p PAG1 -0.270546034117157 0.0581320703577731 -0.0641776217701535 0.737132600565642 miRNATAP -0.148178888931702 0.023547098725257 NA NA NA hsa-miR-181a-5p PAH 0.250113435902954 0.0551933249319293 -1.52529569245637 3.89232247248622e-07 mirMAP -0.755636599073019 1.41162393640504e-11 NA NA NA hsa-miR-181b-5p PAH 0.488256489401108 0.00105321129419701 -1.52529569245637 3.89232247248622e-07 mirMAP -0.798906311595117 8.28060611340199e-17 NA NA NA hsa-miR-146b-5p PAIP2B 0.419719546795449 0.0457375823220155 -2.26694774889415 1.51639004034747e-12 mirMAP -0.255079550750163 0.00082362216882797 NA NA NA hsa-miR-21-5p PAIP2B 1.51084295924322 1.54551622173259e-34 -2.26694774889415 1.51639004034747e-12 miRNATAP -0.581637444658434 1.05014180588205e-06 NA NA NA hsa-miR-224-3p PAIP2B 1.40770116795301 1.31426607144612e-08 -2.26694774889415 1.51639004034747e-12 mirMAP -0.274739015284262 1.84027018226725e-05 NA NA NA hsa-miR-146b-5p PAK3 0.419719546795449 0.0457375823220155 0.150855460957377 0.674226767074732 miRanda -0.288743894927408 0.000493441932863671 NA NA NA hsa-miR-455-5p PAK3 -0.270546034117157 0.0581320703577731 0.150855460957377 0.674226767074732 miRanda -0.701253277265095 6.5172343656553e-09 NA NA NA hsa-miR-192-5p PAK6 -0.50188499512787 0.00344713341196035 0.189417226280461 0.547602921696693 miRNAWalker2_validate -0.370069240297406 2.99780053131704e-05 NA NA NA hsa-miR-19b-3p PALLD 0.601279551368824 0.00016685097085251 0.398313180785046 0.0389413988733361 miRNAWalker2_validate;miRNATAP -0.24745544743575 2.16620232445483e-05 NA NA NA hsa-miR-29c-3p PALM -1.4367517608807 1.61767774905781e-21 -0.0655231523710262 0.759159380054956 miRNATAP -0.132010995786108 0.0448294070203297 NA NA NA hsa-miR-146a-5p PALM2 -0.742958238440575 0.000765983177482633 -2.07895743328401 4.60304002325711e-20 mirMAP -0.236585383998891 4.89758758925479e-06 NA NA NA hsa-miR-17-3p PALM2 0.410352776142368 0.00422200500748636 -2.07895743328401 4.60304002325711e-20 mirMAP -0.219810661077961 0.00653235302499623 NA NA NA hsa-miR-21-5p PALM2 1.51084295924322 1.54551622173259e-34 -2.07895743328401 4.60304002325711e-20 mirMAP -0.717919756509347 7.43976394867784e-18 NA NA NA hsa-miR-19b-3p PALM2-AKAP2 0.601279551368824 0.00016685097085251 -1.02926505695689 4.19912182896168e-20 mirMAP -0.180375856079835 3.10507214392091e-07 NA NA NA hsa-miR-15a-5p PAM 0.349521211668244 0.000770735998804736 -0.165087024136878 0.347728483097048 miRNATAP -0.212456458855537 0.0102306386021498 NA NA NA hsa-miR-222-3p PAN2 1.08574156066353 1.76407192348131e-11 -0.124303685559878 0.24512533602074 miRNAWalker2_validate -0.147597706350808 2.17315530144211e-06 NA NA NA hsa-miR-148a-3p PAN3 -0.748702855596996 3.93313343865641e-07 0.0449402615838541 0.627403000327265 miRNAWalker2_validate -0.103849251615092 0.000540183980733424 NA NA NA hsa-miR-181b-5p PANK1 0.488256489401108 0.00105321129419701 -1.78611804711646 1.3683840906107e-26 mirMAP -0.389465018551984 7.8042991270847e-12 NA NA NA hsa-miR-21-5p PANK3 1.51084295924322 1.54551622173259e-34 -0.310601166776069 0.00575629167578977 mirMAP -0.232870955587185 8.54810274373579e-09 NA NA NA hsa-miR-20a-5p PAPD5 0.854326758727003 5.04256669663285e-07 -0.465833219458179 6.1500280151066e-07 mirMAP -0.135919034114632 2.68881804105274e-07 NA NA NA hsa-miR-455-5p PAPOLG -0.270546034117157 0.0581320703577731 -0.00923157615531744 0.920659446002861 MirTarget;PITA;miRanda;miRNATAP -0.115011925193533 0.000255969429602249 NA NA NA hsa-miR-15a-5p PAPPA 0.349521211668244 0.000770735998804736 -1.03415639268326 0.000196134327811758 MirTarget;miRNATAP -0.515533755193504 8.40972974097998e-05 NA NA NA hsa-miR-192-3p PAPPA -0.6401165114007 0.000266272092403814 -1.03415639268326 0.000196134327811758 mirMAP -0.50726687919749 1.87235845227553e-11 NA NA NA hsa-miR-224-3p PAPPA 1.40770116795301 1.31426607144612e-08 -1.03415639268326 0.000196134327811758 mirMAP -0.142758325665949 0.00914879995832576 NA NA NA hsa-miR-455-5p PAPSS2 -0.270546034117157 0.0581320703577731 -1.24995797203062 1.62046868961677e-13 miRanda -0.141772823209242 0.0178481582357227 NA NA NA hsa-miR-146b-5p PAQR3 0.419719546795449 0.0457375823220155 -0.422130989192833 0.0100177400202432 miRanda -0.105307612194339 0.00565708558560382 NA NA NA hsa-miR-19b-3p PAQR3 0.601279551368824 0.00016685097085251 -0.422130989192833 0.0100177400202432 mirMAP -0.167716154545404 0.000750237886987312 NA NA NA hsa-miR-30b-5p PAQR3 -0.54056186708617 2.44688760798341e-05 -0.422130989192833 0.0100177400202432 mirMAP -0.188272629426301 0.00245927889347987 NA NA NA hsa-miR-505-5p PAQR4 -0.768282569967001 1.14662846595407e-05 1.8466008783271 2.81813263806879e-23 MirTarget -0.193189457703368 0.000351745433857556 NA NA NA hsa-miR-192-3p PAQR5 -0.6401165114007 0.000266272092403814 0.326853439746379 0.42344701227831 mirMAP -0.550070659618596 8.24586636821282e-07 NA NA NA hsa-miR-30e-5p PAQR8 -0.627815042856657 3.02205690184908e-10 0.592484852225167 0.00429681645950127 mirMAP -0.378356018349346 0.000159070309683512 NA NA NA hsa-miR-455-3p PAQR8 -1.3998033821095 5.72010709806871e-17 0.592484852225167 0.00429681645950127 MirTarget;miRNATAP -0.125440623606981 0.032020587558211 NA NA NA hsa-miR-29c-3p PARG -1.4367517608807 1.61767774905781e-21 0.247521704912623 0.000456814401580648 MirTarget;miRNATAP -0.151792960656939 7.16272186090745e-13 NA NA NA hsa-miR-20a-5p PARK2 0.854326758727003 5.04256669663285e-07 -0.287668490464694 0.172950123873518 mirMAP -0.182126283767888 0.00228235578762873 NA NA NA hsa-miR-20b-5p PARK2 0.457668023910379 0.0285865211936156 -0.287668490464694 0.172950123873518 mirMAP -0.162697629053671 0.000902593839437382 NA NA NA hsa-miR-222-3p PARK7 1.08574156066353 1.76407192348131e-11 -0.19227019349302 0.0821556435554917 miRNAWalker2_validate -0.133952581034085 3.49766086748295e-05 NA NA NA hsa-miR-192-5p PARM1 -0.50188499512787 0.00344713341196035 0.492215081013945 0.0241931172963899 miRNAWalker2_validate;mirMAP -0.333971237723307 4.76225412561361e-08 NA NA NA hsa-miR-30b-5p PARP1 -0.54056186708617 2.44688760798341e-05 0.628853958878323 1.64054860772973e-12 miRNAWalker2_validate -0.109943140875542 0.00144778912843681 NA NA NA hsa-miR-21-5p PARP9 1.51084295924322 1.54551622173259e-34 -0.616306428128511 2.79656140991419e-08 miRNAWalker2_validate -0.169817598803572 3.2104242462217e-05 NA NA NA hsa-miR-30c-5p PARP9 -0.432111642767632 0.000159764714931007 -0.616306428128511 2.79656140991419e-08 mirMAP -0.122877488277812 0.0104583801111815 NA NA NA hsa-miR-214-5p PARS2 -1.91497809567701 3.92955595018147e-12 0.348894373574521 6.92206820264045e-05 MirTarget -0.106619817196838 9.65980277478953e-13 NA NA NA hsa-miR-15a-5p PARVA 0.349521211668244 0.000770735998804736 -0.603616827028396 2.29156209936632e-08 MirTarget -0.224314680630344 1.213062514241e-05 NA NA NA hsa-miR-194-5p PARVA -0.292530160992458 0.0996141384876663 -0.603616827028396 2.29156209936632e-08 MirTarget -0.250265332042563 5.14291157910926e-18 NA NA NA hsa-miR-455-5p PARVA -0.270546034117157 0.0581320703577731 -0.603616827028396 2.29156209936632e-08 PITA;miRanda -0.172947683535961 3.35181255308148e-06 NA NA NA hsa-miR-192-5p PASK -0.50188499512787 0.00344713341196035 0.811499355321663 2.31433002104328e-09 miRNAWalker2_validate -0.135088754737217 0.000552979463699365 NA NA NA hsa-miR-505-5p PAX2 -0.768282569967001 1.14662846595407e-05 -0.221560973075754 0.531453941615371 mirMAP -0.265320667017066 0.00657193291202343 NA NA NA hsa-miR-192-3p PAX6 -0.6401165114007 0.000266272092403814 -0.16403255174223 0.257740348671898 mirMAP;miRNATAP -0.100513960944553 0.0119509596740684 NA NA NA hsa-miR-192-3p PAX8 -0.6401165114007 0.000266272092403814 1.00713968822611 1.70021691141874e-06 mirMAP -0.22767346526878 0.000101013774350519 NA NA NA hsa-miR-21-5p PBRM1 1.51084295924322 1.54551622173259e-34 -0.300407126251519 0.000299318324625375 miRNAWalker2_validate -0.18266380398239 9.06357874420144e-10 NA NA NA hsa-miR-20a-5p PBX1 0.854326758727003 5.04256669663285e-07 -1.3362034667203 5.80856733969378e-07 mirMAP -0.167472755856604 0.0294148534171729 NA NA NA hsa-miR-21-5p PBX1 1.51084295924322 1.54551622173259e-34 -1.3362034667203 5.80856733969378e-07 miRNAWalker2_validate -0.391114448383062 7.03160449429696e-05 NA NA NA hsa-miR-224-3p PBX1 1.40770116795301 1.31426607144612e-08 -1.3362034667203 5.80856733969378e-07 mirMAP -0.115838245564904 0.0292844826618325 NA NA NA hsa-miR-182-5p PC 1.96601340710222 4.39326175603633e-09 -1.26401090425995 9.18675557116438e-11 MirTarget;miRNATAP -0.249478269556611 4.51694805156163e-20 NA NA NA hsa-miR-21-5p PCBP2 1.51084295924322 1.54551622173259e-34 -0.236371834912035 0.00019771729259111 MirTarget;miRNATAP -0.110749884572612 1.33904259299185e-06 NA NA NA hsa-miR-20b-5p PCCB 0.457668023910379 0.0285865211936156 -0.680050604129235 3.63211805735208e-09 mirMAP -0.106256276419177 9.2087378747981e-05 NA NA NA hsa-miR-15a-5p PCDH17 0.349521211668244 0.000770735998804736 1.14188483229928 4.69947531605855e-09 MirTarget;miRNATAP -0.25791618273191 0.00583022362413902 NA NA NA hsa-miR-30b-5p PCDH17 -0.54056186708617 2.44688760798341e-05 1.14188483229928 4.69947531605855e-09 MirTarget -0.228601589638792 0.00236304016863109 NA NA NA hsa-miR-455-5p PCDH18 -0.270546034117157 0.0581320703577731 -1.02759479313716 9.87053267234499e-07 miRanda -0.1996185602216 0.00610148876253959 NA NA NA hsa-miR-192-5p PCDH7 -0.50188499512787 0.00344713341196035 -1.76464420465503 6.29135849130623e-08 miRNAWalker2_validate -0.546455946718252 3.39158982574729e-09 NA NA NA hsa-miR-29c-3p PCDHA1 -1.4367517608807 1.61767774905781e-21 2.03421582854944 8.2069018136988e-06 MirTarget -0.521522755095228 0.000225207239876564 NA NA NA hsa-miR-19b-3p PCDHA10 0.601279551368824 0.00016685097085251 -2.05011691863699 3.29170998767101e-07 MirTarget -0.539816221446544 1.11356856445099e-05 NA NA NA hsa-miR-15a-5p PCDHA11 0.349521211668244 0.000770735998804736 -1.46456579546239 0.000248254184143325 MirTarget -0.642595122943484 0.000679926411720936 NA NA NA hsa-miR-19b-3p PCDHA11 0.601279551368824 0.00016685097085251 -1.46456579546239 0.000248254184143325 MirTarget -0.255692165206103 0.0368322538241858 NA NA NA hsa-miR-20a-5p PCDHA11 0.854326758727003 5.04256669663285e-07 -1.46456579546239 0.000248254184143325 MirTarget -0.325273998106852 0.00431756249615817 NA NA NA hsa-miR-15a-5p PCDHA12 0.349521211668244 0.000770735998804736 -2.68228512919554 1.22349401150652e-09 MirTarget -0.626166282955626 0.00316055111748991 NA NA NA hsa-miR-19b-3p PCDHA12 0.601279551368824 0.00016685097085251 -2.68228512919554 1.22349401150652e-09 MirTarget -0.459838782702826 0.000759996316784391 NA NA NA hsa-miR-20a-5p PCDHA12 0.854326758727003 5.04256669663285e-07 -2.68228512919554 1.22349401150652e-09 MirTarget -0.56635301040964 7.84695704223838e-06 NA NA NA hsa-miR-221-3p PCDHA12 1.12244756358612 3.48370308238012e-13 -2.68228512919554 1.22349401150652e-09 MirTarget -0.463108560507881 0.000806976964917824 NA NA NA hsa-miR-222-3p PCDHA12 1.08574156066353 1.76407192348131e-11 -2.68228512919554 1.22349401150652e-09 MirTarget -0.352713899315946 0.00798499710598703 NA NA NA hsa-miR-15a-5p PCDHA13 0.349521211668244 0.000770735998804736 -2.25664029288571 8.67102156279892e-07 MirTarget -0.547327131971439 0.0125054527032041 NA NA NA hsa-miR-19b-3p PCDHA13 0.601279551368824 0.00016685097085251 -2.25664029288571 8.67102156279892e-07 MirTarget -0.476044414733341 0.000726552278862687 NA NA NA hsa-miR-20a-5p PCDHA13 0.854326758727003 5.04256669663285e-07 -2.25664029288571 8.67102156279892e-07 MirTarget -0.586484966556765 7.21344070675617e-06 NA NA NA hsa-miR-221-3p PCDHA13 1.12244756358612 3.48370308238012e-13 -2.25664029288571 8.67102156279892e-07 MirTarget -0.504720242506018 0.000395994502377721 NA NA NA hsa-miR-222-3p PCDHA13 1.08574156066353 1.76407192348131e-11 -2.25664029288571 8.67102156279892e-07 MirTarget -0.447664199302904 0.00107106403814659 NA NA NA hsa-miR-15a-5p PCDHAC1 0.349521211668244 0.000770735998804736 -2.39947483963875 3.46248760946361e-10 MirTarget -0.444239060193802 0.0159453766465085 NA NA NA hsa-miR-19b-3p PCDHAC1 0.601279551368824 0.00016685097085251 -2.39947483963875 3.46248760946361e-10 MirTarget -0.37929044768027 0.00137511924469408 NA NA NA hsa-miR-20a-5p PCDHAC1 0.854326758727003 5.04256669663285e-07 -2.39947483963875 3.46248760946361e-10 MirTarget -0.489261768578764 8.5466725444888e-06 NA NA NA hsa-miR-221-3p PCDHAC1 1.12244756358612 3.48370308238012e-13 -2.39947483963875 3.46248760946361e-10 MirTarget -0.479141329586346 6.12131524523156e-05 NA NA NA hsa-miR-222-3p PCDHAC1 1.08574156066353 1.76407192348131e-11 -2.39947483963875 3.46248760946361e-10 MirTarget -0.416564776222927 0.00028866397987559 NA NA NA hsa-miR-15a-5p PCDHAC2 0.349521211668244 0.000770735998804736 -2.81338526483965 3.55719413756446e-10 MirTarget -0.812553457060012 0.000159227960866064 NA NA NA hsa-miR-19b-3p PCDHAC2 0.601279551368824 0.00016685097085251 -2.81338526483965 3.55719413756446e-10 MirTarget -0.529712952553144 0.000134221296559573 NA NA NA hsa-miR-20a-5p PCDHAC2 0.854326758727003 5.04256669663285e-07 -2.81338526483965 3.55719413756446e-10 MirTarget -0.6966287827296 5.55532984843863e-08 NA NA NA hsa-miR-221-3p PCDHAC2 1.12244756358612 3.48370308238012e-13 -2.81338526483965 3.55719413756446e-10 MirTarget -0.579687250037446 3.54355659202688e-05 NA NA NA hsa-miR-222-3p PCDHAC2 1.08574156066353 1.76407192348131e-11 -2.81338526483965 3.55719413756446e-10 MirTarget -0.368800288617871 0.00640818455955297 NA NA NA hsa-miR-455-5p PCDHB9 -0.270546034117157 0.0581320703577731 0.288755897241481 0.258411268157165 miRanda -0.234576403113675 0.00729945704726391 NA NA NA hsa-miR-29c-3p PCGF3 -1.4367517608807 1.61767774905781e-21 0.167536921370584 0.0398744101142924 MirTarget;miRNATAP -0.134518678739105 4.89532557201664e-08 NA NA NA hsa-miR-15a-5p PCGF5 0.349521211668244 0.000770735998804736 -0.536598424916245 4.26862146890107e-10 miRNATAP -0.188002957273202 4.19595398334933e-06 NA NA NA hsa-miR-21-5p PCGF5 1.51084295924322 1.54551622173259e-34 -0.536598424916245 4.26862146890107e-10 mirMAP -0.23487459167029 3.37819673993488e-14 NA NA NA hsa-miR-182-5p PCOLCE2 1.96601340710222 4.39326175603633e-09 -0.290703988032813 0.388022584574282 miRNAWalker2_validate -0.118239120984521 0.0137632557544773 NA NA NA hsa-miR-215-5p PCOLCE2 -0.981544773246509 3.14452272477156e-05 -0.290703988032813 0.388022584574282 miRNAWalker2_validate -0.253873956699374 0.000217496345803066 NA NA NA hsa-miR-21-5p PCSK6 1.51084295924322 1.54551622173259e-34 -1.18950076181489 3.29501368019698e-09 MirTarget;miRNATAP -0.577125974927784 1.46237272255029e-15 NA NA NA hsa-miR-99b-5p PCSK9 -0.204769880349524 0.240836989110525 0.423836119666947 0.0754546259825649 MirTarget -0.288318469933817 1.35849704859545e-05 NA NA NA hsa-miR-146b-5p PCYOX1 0.419719546795449 0.0457375823220155 -0.710952952600329 8.62737880229856e-10 miRanda -0.13290659331826 9.47265845294838e-07 NA NA NA hsa-miR-181a-5p PCYOX1 0.250113435902954 0.0551933249319293 -0.710952952600329 8.62737880229856e-10 mirMAP -0.271426700724814 4.40321593832289e-10 NA NA NA hsa-miR-181b-5p PCYOX1 0.488256489401108 0.00105321129419701 -0.710952952600329 8.62737880229856e-10 mirMAP -0.278018118123087 1.20321689740947e-13 NA NA NA hsa-miR-20a-5p PCYT1A 0.854326758727003 5.04256669663285e-07 -0.115598905849767 0.125639430650331 mirMAP -0.107568239494339 3.08655718171154e-07 NA NA NA hsa-miR-503-5p PCYT2 0.191949282338049 0.268420664548092 0.00446147360920346 0.974419085805155 mirMAP -0.16352699467993 2.55022962077384e-05 NA NA NA hsa-miR-652-3p PCYT2 0.135945800164278 0.391695970197646 0.00446147360920346 0.974419085805155 mirMAP -0.135920894786483 0.00145200498251837 NA NA NA hsa-miR-19b-3p PDCD1LG2 0.601279551368824 0.00016685097085251 -1.71871038152299 5.07295006749358e-14 MirTarget -0.342937390471194 1.31998070601128e-06 NA NA NA hsa-miR-20a-5p PDCD1LG2 0.854326758727003 5.04256669663285e-07 -1.71871038152299 5.07295006749358e-14 MirTarget -0.412141774307485 3.1199013893093e-10 NA NA NA hsa-miR-455-5p PDCD1LG2 -0.270546034117157 0.0581320703577731 -1.71871038152299 5.07295006749358e-14 miRanda -0.358832348838849 7.43142841369956e-06 NA NA NA hsa-miR-21-5p PDCD4 1.51084295924322 1.54551622173259e-34 -0.0963058046431708 0.345660764291274 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.133707586805023 0.000300820272836491 22322403;23604124;20978511;25973032;25575817;25316501;22072622;22267128;19836969;22212233;25520758;19682430;23272133;25477028;26252635;25994220;25991676;22747440;23827854;23824073;24865582;24902663;24888238;24149370;17991735;22689922;27355932;19308091;24331411;26169933;22547075;20372781;23558936;23201752;20815812;17968323;25310697;21842656;23567619;20581857;23888942;23548551;19013014;21685938;26142886;24472409;26418978;24659669;22086602;26212010;25543482;25543261;23904372;27725205;23564788;25400316;26150475;21546206;19509156;27035745;23052036;22353043;19633292;25566594;21412018;19276261;21330826;26864640;22335905;21636706 miR 21 promotes migration and invasion by the miR 21 PDCD4 AP 1 feedback loop in human hepatocellular carcinoma; The expression level of miR-21 was inversely correlated with the protein expression level of a previously identified target gene programmed cell death 4 PDCD4;HBx mediated miR 21 upregulation represses tumor suppressor function of PDCD4 in hepatocellular carcinoma; HBx downregulates PDCD4 expression at least partially through miR-21; Taken together this study reported for the first time that HBx downregulates PDCD4 and upregulates miR-21 expression; The deregulation of PDCD4 by HBx through miR-21 represents a potential novel mechanism of the downregulation of PDCD4 in HBV-related HCC and provides new insights into HCC development;Transfection of anti-miR-21 rendered HCC cells sensitive to IFN-α/5-FU and such sensitivity was weakened by transfection of siRNAs of target molecules PETN and PDCD4 miR-21 expression in clinical HCC specimens was significantly associated with the clinical response to the IFN-α/5-FU combination therapy and survival rate;PDCD4 and PTEN expression was decreased gradually after tumor induction and negatively correlated with miR-21 expression; Our in vivo experiments further confirmed that miR-21 plays an important role in promoting the occurrence and development of HCC by regulating PDCD4 and PTEN;We identified miR-21 was directly downregulated by RBP2 and found that miR-21 downregulated PDCD4 expression in leukemia cells;MTCs were consistently associated with miR-21 up-regulation P < .0016 and featured significant PDCD4 nuclear down-regulation; An inverse correlation emerged between miR-21 overexpression and PDCD4 down-regulation P = .0013; This study showed in MTCs that miR-21 regulates PDCD4 expression and also that the miR-21/PDCD4 pathway correlates with clinicopathological variables and prognosis;Although microRNA-21 miR-21 is emerging as an oncogene and has been shown to target several tumor suppressor genes including programmed cell death 4 PDCD4 its precise mechanism of action on cancer stem cells CSCs is unclear; Herein we report that FOLFOX-resistant HCT-116 and HT-29 cells that are enriched in CSCs show a 3- to 7-fold upregulation of pre- and mature miR-21 and downregulation of PDCD4; Likewise overexpression of miR-21 in HCT-116 cells achieved through stable transfection led to the downregulation of PDCD4 and transforming growth factor beta receptor 2 TGFβR2;Prognostic significance of PDCD4 expression and association with microRNA 21 in each Dukes' stage of colorectal cancer patients; Furthermore relationships between the PDCD4 mRNA and microRNA-21 miR-21 were evaluated; The PDCD4 mRNA was investigated by the quantitative real-time RT-PCR method and miR-21 was examined by TaqMan microRNA assays; Significant inverse correlations were demonstrated between PDCD4 and miR-21;This short review will focus on our recent finding that the microRNA miR-21 posttranscriptionally regulates Pdcd4 as well as invasion intravasation and metastasis;PDCD4 expression inversely correlated with miR 21 levels in gastric cancers;MicroRNA 21 Down regulates Rb1 Expression by Targeting PDCD4 in Retinoblastoma; MicroRNA-21 miR-21 possesses the oncogenic potential to target several tumor suppressor genes including PDCD4 and regulates tumor progression and metastasis; However the mechanism of how miR-21 regulates PDCD4 is poorly understood in RB; Using the TargetScan program we identified a list of potential target genes of these miRNAs of which PDCD4 is one the targets of miR-21; In this study we focused on the regulatory mechanism of miR-21 on PDCD4 in RB; We demonstrated an inverse correlation between miR-21 and PDCD4 expression in Weri-Rb1 and Y79 cells; These data suggest that miR-21 down-regulates Rb1 by targeting PDCD4 tumor suppressor;MicroRNA 21 promotes cell proliferation and down regulates the expression of programmed cell death 4 PDCD4 in HeLa cervical carcinoma cells; In this study we found that the inhibition of miR-21 in HeLa cervical cancer cells caused profound suppression of cell proliferation and up-regulated the expression of the tumor suppressor gene PDCD4;Additionally resveratrol increased the expression of tumor suppressors PDCD4 and maspin which are negatively regulated by miR-21; Short interfering si RNA against PDCD4 attenuated resveratrol's effect on prostate cancer cells and similar effects were observed following over expression of miR-21 with pre-miR-21 oligonucleotides; MiR-21 expression in these cells appeared to be dependent on Akt as LY294002 reduced the levels of miR-21 along with a concurrent increase in PDCD4 expression; These tumor- and metastatic-suppressive effects of resveratrol were associated with reduced miR-21 and pAkt and elevated PDCD4 levels;The expression of miR-21 and PDCD4 mRNA in transfected cells was quantified by real-time polymerase chain reaction and the expression of PDCD4 protein by Western blot; Cell proliferation apoptosis migration and invasion assays were performed to determine the biological effects of miR-21 expression and PDCD4 inhibition; Co-transfection of miR-21-sponge with PDCD4 siRNA upregulated miR-21 expression in these cells; PDCD4 mRNA and protein levels were increased 2.14-fold and 2.16-fold respectively following inhibition of miR-21 expression; Depletion of PDCD4 by siRNA transfection reversed the reduction of cell proliferation migration and invasion induced by inhibition of miR-21 in A549 cells; It indicates that miR-21 is highly expressed in patients with NSCLC and inhibition of miR-21 expression reduces proliferation migration and invasion of A549 cells by upregulating PDCD4 expression; Modulation of miR-21 or PDCD4 expression may provide a potentially novel therapeutic approach for NSCLC;IL 6 Inhibits the Targeted Modulation of PDCD4 by miR 21 in Prostate Cancer; In this study we evaluated the role of IL-6 in PDCD4 gene expression and how the microRNA miR-21 regulates this process in prostate cancer cell lines PC-3 and LNCaP; The expression of PDCD4 was inhibited by IL-6 but this effect was weakened in cell lines with low expression of miR-21; These findings support the feasibility of future efforts for diagnosis and gene therapy for prostate cancer that are based on IL-6 miR-21 and PDCD4;Furthermore the absence of miR-21 increased the expression of its target gene PDCD4 and subsequently modulated nuclear factor NF-κB activation;In this study using reverse phase protein arrays RPPAs we assessed MPS1 mediated cell signaling pathways and demonstrated that inhibiting MPS1 could upregulate the expression of the tumor suppressor PDCD4 and MSH2 genes by down regulating micro RNA-21 miR-21; We also show the prognostic effect of miR21 PDCD4 and MSH2 levels to patient survival across different GBM molecular subtypes;We also analyzed the immunohistochemical expression of PDCD4 an miR-21 gene target; PDCD4 expression was significantly downregulated in MTC samples consistent with miR-21 upregulation;Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA 21 mediated programmed cell death 4 PDCD4 expression; Further AR inhibition also increased PDCD4 a putative target of miR-21 in human colon cancer cells; Collectively these results indicate that AR inhibition prevents growth factor-induced colon cancer growth by down-regulating miR-21 expression and increasing PDCD4 levels through the reactive oxygen species ROS/AMPK/mTOR/AP1/4E-BP1 pathway;Berberine could inhibit miR-21 expression and function in ovarian cancer as shown by an enhancement of its target PDCD4 an important tumor suppressor in ovarian cancer;Overexpression of miR-21 in cisplatin sensitive cells decreased PDCD4 levels and increased cell proliferation;MicroRNA 21 miR 21 post transcriptionally downregulates tumor suppressor PDCD4 and promotes cell transformation proliferation and metastasis in renal cell carcinoma; MiR-21 induces neoplastic transformation cell proliferation and metastasis and downregulates programmed cell death4 PDCD4 in some cancers; The aim of this study was to investigate the roles and interactions of PDCD4 and miR-21 in human renal cell carcinoma RCC; The expression levels of PDCD4 protein and mRNA and miR-21 were examined by Western blot analysis and by qRT-PCR and luciferase reporter assays; MiR-21 not only promoted cancer cell hyperplasia and contributed to tumor cell transformation and metastasis but also post-transcriptionally downregulated PDCD4 protein expression; PDCD4 and miR-21 expression levels potentially play an important role in renal cell cancer;Programmed cell death 4 PDCD4 is a tumor suppressor gene whose expression is directly controlled by microRNA-21 miR-21; This PDCD4 and miR-21 inverse expression was also noted in cells and exosomes from OSC peritoneal effusions compared with nonneoplastic effusions; PDCD4 and miR-21 are involved in OSC oncogenesis;Finally in a subgroup of tumor specimens ROC curve analysis performed on quantitative PCR data sets for miR-21 ITGβ4 and PDCD4 shows that the combination of high miR-21 with low ITGβ4 and PDCD4 expression is able to predict presence of metastasis; In conclusion miR-21 is a key player in oncogenic EMT its overexpression is controlled by the cooperation of genetic and epigenetic alterations and its levels along with ITGβ4 and PDCD4 expression could be exploited as a prognostic tool for CRC metastasis;Programmed cell death 4 PDCD4 is an important functional target of the microRNA miR 21 in breast cancer cells;In ZD esophagus and tongue oncogenic miR-31 and miR-21 overexpression was accompanied by down-regulation of their respective tumor-suppressor targets PPP2R2A and PDCD4;Due to inhibition of miR-21 expression of the programed cell death 4 PDCD4 gene was promoted in tumors resulting in the induction of apoptosis of tumor cells;We also demonstrated that BMP-6-induced downregulation of miR-21 modified the activity of PDCD4 3'UTR and inhibited MDA-MB-231 cell invasion;The level of miR-21 was reversely correlated with the expression of PTEN and PDCD4 and positive correlated with PI3K/Akt pathway; miR-21 is involved in acquired resistance of EGFR-TKI in NSCLC which is mediated by down-regulating PTEN and PDCD4 and activating PI3K/Akt pathway;The results indicated that the miR-21 inhibition could induce the cell cycle arrest in G1 phase upregulate the expression of Programmed Cell Death Protein 4 PDCD4 and thus active the caspase-3 apoptosis pathway;Induction of miR-21 may enable cancer cells to elude DNA damage-induced apoptosis and enhance the metastatic potential of breast cancer cells through repressing expression of PTEN and PDCD4;Clinicopathological and prognostic significance of PDCD4 and microRNA 21 in human gastric cancer; Recent studies have demonstrated that the novel tumor suppressor protein programmed cell death 4 PDCD4 is downregulated in several human solid cancer types and is suppressed by microRNA-21 miR-21; The objectives of this study were: i to establish the clinicopathological and prognostic significance of PDCD4 mRNA and ii to elucidate any correlation between PDCD4 mRNA and miR-21 in gastric cancer; We also performed an association study comparing PDCD4 mRNA and miR-21 in eight cell lines and 49 gastric cancers; An inverse correlation between PDCD4 mRNA and miR-21 was found in gastric cancer; Furthermore our findings suggest that PDCD4 mRNA is negatively regulated by miR-21 in gastric cancer and may serve as a target for effective therapies;Furthermore miR-21 mimic or inhibitor significantly reduced or increased the expression of PDCD4 and TPM1; MiR-21 is overexpressed in RCC tissue and modulates the growth apoptosis and cell cycle progression of RCC cells and regulates the expression of PDCD4 and TPM1;Moreover we demonstrate that oligonucleotide-mediated miR-21 silencing in U87 human GBM cells resulted in increased levels of the tumor suppressors PTEN and PDCD4 caspase 3/7 activation and decreased tumor cell proliferation;Curcumin treatment reduced miR-21 promoter activity and expression in a dose-dependent manner by inhibiting AP-1 binding to the promoter and induced the expression of the tumour suppressor Pdcd4 programmed cell death protein 4 which is a target of miR-21; Taken together this is the first paper to show that curcumin inhibits the transcriptional regulation of miR-21 via AP-1 suppresses cell proliferation tumour growth invasion and in vivo metastasis and stabilizes the expression of the tumour suppressor Pdcd4 in colorectal cancer;MicroRNA 21 miR 21 post transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion intravasation and metastasis in colorectal cancer; This is the first study to show that Pdcd4 is negatively regulated by miR-21;Inflammation and MiR 21 pathways functionally interact to downregulate PDCD4 in colorectal cancer; These findings indicate that miR-21 is a component of the COX-2 inflammation pathway and that this pathway promotes worsening of disease stage in colorectal cancer by inducing accumulation of PGE2 and increasing expression of miR-21 with consequent downregulation of the tumour suppressor gene PDCD4;The expression of miR-21 PTEN and PDCD4 were determined by Real-time PCR; Glossy ganoderma spore oil down-regulated the expression of miR-21 and up-regulated the expression of PTEN and PDCD4 significantly;Interestingly NVP-LDE-225 induced PDCD4 and apoptosis and inhibited cell viability by suppressing miR-21;PDCD4 a direct target gene of miR-21 could mediate chemoresistance to docetaxel in PC3 cells;Oxidative stress upregulates PDCD4 expression in patients with gastric cancer via miR 21; The expression of miR-21 and PDCD4 was highly correlated with the degree of differentiation tumor staging local lymphatic node metastasis and remote metastasis; In addition the relative expression of PDCD4 was negatively correlated with miR-21; Thus we conclude that ROS promotes gastric carcinogenesis via upregulating miR-21 expression which in turn down-regulates the expression of PDCD4 in gastric cancer cells;Moreover knockdown of miR-21 increased PDCD4 and PTEN expression at the protein level but not at the mRNA level;MicroRNA 21 down regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G; Expression of PDCD4 protein correlates inversely with expression of miR-21 in a number of human glioblastoma cell lines such as T98G A172 U87 and U251; Inhibition of miR-21 increases endogenous levels of PDCD4 in cell line T98G and over-expression miR-21 inhibits PDCD4-dependent apoptosis;Treatment of HSC-3 cells with Nanog- and/or Stat-3-specific small interfering RNAs effectively blocks HA-mediated Nanog-Stat-3 signaling events abrogates miR-21 production and increases PDCD4 expression;Programmed cell death 4 PDCD4 is critical in mediating apoptosis in GBM and is downregulated by miR-21 which may mediate the resistance of glioblastoma cells against chemotherapy or radiation via its target genes PDCD4; This review will focus on the roles of miRNAs family members particularly miR-21 and its target gene PDCD4 in tumors like glioblastoma and new targeting strategies as examples some new targeting therapeutic methods and molecular mechanisms of signal pathways in glioblastoma therapeutics to give the reader the current trends of approach to target regulation of these miRNA and genes for future glioma therapies;Using Western blot analysis miR-21 knockdown enhanced the expression of tumor suppressor PDCD4 and attenuated apoptosis inhibitor c-IAP2;METHODS 3-45-dimethylthiazol-2-yl-25-diphenyltetrazolium bromide MTT assay was used to determine the effect of 5-FU on the viability of RKO cells with knockout of miR-21 or high expression of PDCD4;The protein levels of miR-21 targets PTEN and PDCD4 were estimated; In the control experiment miR-21 mimic significantly inhibited the expression of PTEN and PDCD4 proteins in the two gastric cell lines leading to an increase in cell invasion and migration; miR-21 is overexpressed in gastric cancer and its aberrant expression may have important role in gastric cancer growth and dissemination by modulating the expression of the tumor suppressors PTEN and PDCD4 as well as by modulating the pathways involved in mediating cell growth migration invasion and apoptosis;The effects were accompanied by up-regulation of tumor suppressor PDCD4 a known miR-21 target; as well as up-regulation of cofilin and profilin two key proteins involved in actin polymerization and cytoskeleton maintenance as a consequence of miR-182 down-regulation;Increased levels of miR-21 in turn downregulate the expression of the metastasis-suppressor protein programmed cell death 4 PDCD4 a validated miR-21 target;Moreover knockdown of miR-21 increased the expressions of PDCD4 and PTEN at the protein level but not at the mRNA level;In this study we analyzed the expression of miR-21 and of its target PDCD4 Programmed Cell Death 4 during normal hematopoietic differentiation and in AMLs;MiR 21 mediates the radiation resistance of glioblastoma cells by regulating PDCD4 and hMSH2; In addition miR-21 knockdown increased the expression of endogenous PDCD4 and hMSH2 which contributed to the apoptosis and G2 arrest of T98G cells; The findings suggested that miR-21 may mediate the resistance of glioblastoma cells against radiation via its target genes PDCD4 and hMSH2;The results showed that upon exposure to mUA miR-21 expression was decreased and the expression of PTEN and Pdcd4 protein was elevated;The expression of programmed cell death-4 PDCD4 was increased by I3C and reduced by miR-21 transfection; Such enhanced chemosensitivity might be explained by the increased expression of PDCD4 which is a downstream target which miR-21 negatively regulates;It has been reported that miR-21 was upregulated in most malignant cancers the proposed mechanism of which was through suppressing expression of programmed cell death 4 PDCD4; In present study it is firstly reported that miR-21 was upregulated in Kazakh's ESCC and that miR-21 played a negative role in regulating PDCD4 using in situ hybridization ISH and luciferase reporter approach;To measure levels of microRNA miR-21 and its target gene programmed cell death 4 PDCD4 in samples of human cutaneous malignant melanoma and normal non-malignant control skin; Relative levels of miR-21 and PDCD4 mRNA were measured using a quantitative real-time reverse transcription-polymerase chain reaction; Compared with normal skin samples the relative level of miR-21 was significantly higher and the relative level of PDCD4 mRNA was significantly lower in the melanoma specimens; A significant negative correlation between PDCD4 mRNA and miR-21 was demonstrated in malignant melanoma r = -0.602; Elevated miR-21 and reduced PDCD4 mRNA levels were both significantly correlated with increased tumour size a higher Clark classification level and the presence of lymph node metastases in malignant melanoma; These findings suggest that miR-21 and PDCD4 might be potential biomarkers for malignant melanoma and might provide treatment targets in the future;MicroRNA 21 and PDCD4 expression in colorectal cancer; Studies have shown that miR-21 exerts its oncogenic activity by targeting the PDCD4 tumour suppressor 3'-UTR; The purpose of this study was to delineate the interaction between PDCD4 and its oncogenic modulator miR-21 in colorectal cancer; A cohort of 48 colorectal tumours 61 normal tissues and 7 polyps were profiled for miR-21 and PDCD4 gene expression; A significant inverse relationship between miR-21 and PDCD4 gene expression p < 0.001 was identified by RT-qPCR; In addition significant reduction of PDCD4 p < 0.001 expression and reciprocal upregulation of miR-21 p = 0.005 in a progressive manner from tumour-polyp-normal mucosae was identified; This study demonstrates the inverse relationship between miR-21 and PDCD4 thus suggesting that miR-21 post-transcriptionally modulates PDCD4 via mRNA degradation;Expression patterns of miR-21 RNA and its target tumor suppressor protein PDCD4 were mutually exclusive;Exosome shuttling microRNA 21 promotes cell migration and invasion targeting PDCD4 in esophageal cancer;Fenhexamid and fludioxonil stimulated miR-21 expression in a concentration-dependent manner and reduced the expression of miR-21 target Pdcd4 protein; Antisense to miR-21 blocked the increase in Pdcd4 protein by fenhexamid and fludioxonil;The expression of programmed cell death 4 PDCD4 which is a miR-21 targeting apoptotic gene has also been enhanced by UA; And over-expression of miR-21 in U251 cells abolished the enhancement of PDCD4 protein by UA;This process leads to microRNA-21 miR-21 production and a tumor suppressor protein e.g PDCD4 program cell death 4 reduction; Transfection of MCF-7 cells with PKCepsilon or Nanog-specific small interfering RNAs effectively blocks HA-mediated PKCepsilon-Nanog signaling events abrogates miR-21 production and increases PDCD4 expression/eIF4A binding;Through dual-luciferase method it was verified that PDCD4 and PDCD10 were real target genes of miR-21 and miR-200c respectively;miR-21 and miR-155 expression was assessed in tumor tissue and in adjacent normal tissue of 156 CRC patients by TaqMan MicroRNA assays and PDCD4 and TP53INP1 mRNA levels were measured by quantitative real-time reverse transcriptase PCR RT-PCR; Significant inverse correlations were demonstrated between miR-21 and PDCD4 mRNA and miR-155 and TP53INP1 mRNA;The aim of this study was a to determine a role of microRNA-21 in esophageal squamous cell carcinoma and b to elucidate the regulation of the programmed cell death 4 PDCD4 gene by microRNA-21; In addition the regulation of PDCD4 by microRNA-21 was elucidated to identify the mechanisms of this regulation; The PDCD4 protein levels in esophageal squamous cell carcinoma cells have an inverse correlation with microRNA-21 expression; MicroRNA-21 targets PDCD4 at the posttranscriptional level and regulates cell proliferation and invasion in esophageal squamous cell carcinoma;Maspin Pdcd4 and miR-21 expressions were evaluated by a real-time polymerase chain reaction in 20 endometrial cancer and 10 normal endometrium samples; Comparison between IA and more advanced International Federation of Gynecology and Obstetrics stages of endometrial cancer in regard to expression levels of maspin Pdcd4 and miR-21 did not reveal any significant differences;MicroRNA 21 induces 5 fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4; The proresistance effects of miR-21 were attributed to the attenuated expression of tumor suppressor genes including PTEN and PDCD4;Sequence prediction and gene expression regulation assays showed that miR-21 could reversely regulate the expression of PDCD4 P < 0.01; Suppression of miR-21 expression is associated with an elevation of Pdcd4 resulting in a significant reduction of proliferation and the apoptosis rate 2.6% was increased to 10.9%; Moreover the anti-proliferation and pro-apoptotic effect by miR-21 suppression could be reversed by PDCD4 knock down;Downregulation of Pdcd4 by mir 21 facilitates glioblastoma proliferation in vivo; We demonstrate that downregulation of mir-21 in glioblastoma-derived cell lines results in increased expression of its target programmed cell death 4 Pdcd4 a known tumor-suppressor gene; In addition our data indicate that either downregulation of mir-21 or overexpression of its target Pdcd4 in glioblastoma-derived cell lines leads to decreased proliferation increased apoptosis and decreased colony formation in soft agar; Using a glioblastoma xenograft model in immune-deficient nude mice we observe that glioblastoma-derived cell lines in which mir-21 levels are downregulated or Pdcd4 is over-expressed exhibit decreased tumor formation and growth; These critical in vivo findings demonstrate an important functional linkage between mir-21 and Pdcd4 and further elucidate the molecular mechanisms by which the known high level of mir-21 expression in glioblastoma can attribute to tumorigenesis--namely inhibition of Pdcd4 and its tumor-suppressive functions ;;poor survival;drug resistance;;;worse prognosis;;staging;metastasis;;metastasis;progression;;;;;;poor survival;;;;;metastasis;;metastasis;;;;;drug resistance;;;;progression;;metastasis;metastasis;staging;;;drug resistance;staging;metastasis;differentiation;tumorigenesis;;;;drug resistance;;;;;metastasis;;differentiation;drug resistance;;;malignant trasformation;malignant trasformation;metastasis;progression;;cell migration;;;;;;;staging;drug resistance;;tumorigenesis liver cancer;liver cancer;liver cancer;liver cancer;chronic myeloid leukemia;thyroid cancer;colon cancer;colorectal cancer;colon cancer;gastric cancer;retinoblastoma;cervical and endocervical cancer;prostate cancer;lung squamous cell cancer;prostate cancer;colorectal cancer;glioblastoma;thyroid cancer;colon cancer;ovarian cancer;ovarian cancer;kidney renal cell cancer;ovarian cancer;colorectal cancer;breast cancer;esophageal cancer;glioblastoma;breast cancer;lung squamous cell cancer;breast cancer;breast cancer;gastric cancer;kidney renal cell cancer;glioblastoma;colorectal cancer;colorectal cancer;colorectal cancer;lung cancer;prostate cancer;prostate cancer;gastric cancer;B cell lymphoma;glioblastoma;head and neck cancer;glioblastoma;ovarian cancer;colon cancer;gastric cancer;breast cancer;breast cancer;B cell lymphoma;acute myeloid leukemia;glioblastoma;prostate cancer;pancreatic cancer;esophageal cancer;melanoma;colorectal cancer;colorectal cancer;esophageal cancer;breast cancer;glioblastoma;breast cancer;breast cancer;colorectal cancer;esophageal cancer;endometrial cancer;pancreatic cancer;lung squamous cell cancer;glioblastoma hsa-miR-181a-5p PDCD6IP 0.250113435902954 0.0551933249319293 -0.0996773536816402 0.0954765940413755 miRNATAP -0.113183997155323 2.57177457947147e-07 NA NA NA hsa-miR-181b-5p PDCD6IP 0.488256489401108 0.00105321129419701 -0.0996773536816402 0.0954765940413755 miRNATAP -0.104831362602946 3.84001514613507e-08 NA NA NA hsa-miR-146b-5p PDE10A 0.419719546795449 0.0457375823220155 -0.489848882980236 0.0167561652560711 miRanda -0.172730901383096 0.000267020864095937 NA NA NA hsa-miR-34a-5p PDE4B 1.03694231790865 5.74864019540594e-14 -1.30083898680808 1.55011568537053e-09 MirTarget -0.266496668743165 0.000397652496653674 NA NA NA hsa-miR-19b-3p PDE4D 0.601279551368824 0.00016685097085251 -0.666934323578114 0.000685777052439917 miRNAWalker2_validate -0.157006646459827 0.0088656715735691 NA NA NA hsa-miR-224-3p PDE4D 1.40770116795301 1.31426607144612e-08 -0.666934323578114 0.000685777052439917 mirMAP -0.102870903172725 0.00779840382627374 NA NA NA hsa-miR-455-5p PDE4D -0.270546034117157 0.0581320703577731 -0.666934323578114 0.000685777052439917 miRanda -0.456549853680975 4.5814092760497e-12 NA NA NA hsa-miR-181a-5p PDE4DIP 0.250113435902954 0.0551933249319293 -0.268391772056326 0.0604161803169821 mirMAP -0.26645098858348 5.07637854559174e-07 NA NA NA hsa-miR-181b-5p PDE4DIP 0.488256489401108 0.00105321129419701 -0.268391772056326 0.0604161803169821 mirMAP -0.306617891821878 1.76198320183446e-11 NA NA NA hsa-miR-30b-5p PDE4DIP -0.54056186708617 2.44688760798341e-05 -0.268391772056326 0.0604161803169821 mirMAP -0.1919280449465 0.000376676979298117 NA NA NA hsa-miR-409-3p PDE4DIP -0.499649792570937 0.0526751181520117 -0.268391772056326 0.0604161803169821 mirMAP -0.12465753043893 3.09133211669812e-06 NA NA NA hsa-miR-148a-3p PDE5A -0.748702855596996 3.93313343865641e-07 0.186921756686946 0.309659365294452 MirTarget -0.553041668936523 3.21460058912989e-22 NA NA NA hsa-miR-19b-3p PDE5A 0.601279551368824 0.00016685097085251 0.186921756686946 0.309659365294452 MirTarget;miRNATAP -0.168780470292063 0.00246811157107229 NA NA NA hsa-miR-30e-5p PDE5A -0.627815042856657 3.02205690184908e-10 0.186921756686946 0.309659365294452 MirTarget;mirMAP -0.21571196183321 0.0152323431082456 NA NA NA hsa-miR-132-3p PDE7B 0.323796239695997 0.00272093067935091 -2.15823176849595 1.26609046048699e-26 miRNATAP -0.307821745799419 0.00161696723612651 NA NA NA hsa-miR-146b-5p PDE7B 0.419719546795449 0.0457375823220155 -2.15823176849595 1.26609046048699e-26 miRanda;mirMAP -0.233164751885736 2.52982123677996e-06 NA NA NA hsa-miR-182-5p PDE7B 1.96601340710222 4.39326175603633e-09 -2.15823176849595 1.26609046048699e-26 miRNATAP -0.104413850738381 0.000658994167391884 NA NA NA hsa-miR-19b-3p PDE7B 0.601279551368824 0.00016685097085251 -2.15823176849595 1.26609046048699e-26 miRNATAP -0.314252306415736 1.27352560965679e-06 NA NA NA hsa-miR-20a-5p PDE7B 0.854326758727003 5.04256669663285e-07 -2.15823176849595 1.26609046048699e-26 mirMAP;miRNATAP -0.402508154704112 1.59163039354182e-11 NA NA NA hsa-miR-20a-5p PDGFRA 0.854326758727003 5.04256669663285e-07 -3.44515402293711 2.35408080284508e-16 MirTarget;miRNATAP -0.429411714989606 0.000497563648177803 NA NA NA hsa-miR-34a-5p PDGFRA 1.03694231790865 5.74864019540594e-14 -3.44515402293711 2.35408080284508e-16 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -1.20419826674778 7.99910511006868e-17 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-29c-3p PDGFRB -1.4367517608807 1.61767774905781e-21 0.903688818724302 2.6429876964178e-08 miRNATAP -0.139148992716859 0.00615874031219039 NA NA NA hsa-miR-181b-5p PDHX 0.488256489401108 0.00105321129419701 -0.357960061322459 1.41986259575707e-06 miRNAWalker2_validate -0.18548710492398 4.00606242537035e-15 NA NA NA hsa-miR-181a-5p PDIK1L 0.250113435902954 0.0551933249319293 -0.0468630905538001 0.608073460423057 MirTarget;mirMAP -0.174894628985528 2.14404848975164e-07 NA NA NA hsa-miR-181b-5p PDIK1L 0.488256489401108 0.00105321129419701 -0.0468630905538001 0.608073460423057 MirTarget;mirMAP -0.170220598980027 5.63481141361996e-09 NA NA NA hsa-miR-221-3p PDIK1L 1.12244756358612 3.48370308238012e-13 -0.0468630905538001 0.608073460423057 miRNAWalker2_validate -0.105968800033143 0.000140077432892211 NA NA NA hsa-miR-146b-5p PDK4 0.419719546795449 0.0457375823220155 -2.10593846974081 2.90436387273985e-14 miRanda -0.148384345916936 0.0255487263822663 NA NA NA hsa-miR-181a-5p PDK4 0.250113435902954 0.0551933249319293 -2.10593846974081 2.90436387273985e-14 miRNATAP -0.786697156863788 4.65275744763913e-14 NA NA NA hsa-miR-181b-5p PDK4 0.488256489401108 0.00105321129419701 -2.10593846974081 2.90436387273985e-14 miRNATAP -0.898754768262503 2.51839642855176e-24 NA NA NA hsa-miR-17-3p PDLIM2 0.410352776142368 0.00422200500748636 -0.897556099359769 5.80962825020819e-13 mirMAP -0.128726996730082 0.00307950600549556 NA NA NA hsa-miR-192-5p PDLIM3 -0.50188499512787 0.00344713341196035 -0.00843150695562267 0.968939178058972 miRNAWalker2_validate -0.496585206955558 4.0087952271627e-17 NA NA NA hsa-miR-215-5p PDLIM3 -0.981544773246509 3.14452272477156e-05 -0.00843150695562267 0.968939178058972 miRNAWalker2_validate -0.120078512676734 0.00667937629153091 NA NA NA hsa-miR-15a-5p PDLIM5 0.349521211668244 0.000770735998804736 -1.19395917699233 9.15580988544115e-26 miRNATAP -0.322802980091937 8.69229657101317e-09 NA NA NA hsa-miR-181a-5p PDLIM5 0.250113435902954 0.0551933249319293 -1.19395917699233 9.15580988544115e-26 mirMAP -0.173322259402769 0.000124903238530117 NA NA NA hsa-miR-181b-5p PDLIM5 0.488256489401108 0.00105321129419701 -1.19395917699233 9.15580988544115e-26 mirMAP -0.150138356163127 0.000133458965863036 NA NA NA hsa-miR-15a-5p PDP1 0.349521211668244 0.000770735998804736 -0.55248328428444 0.00829430941999616 MirTarget -0.269198191792457 0.00645396045471257 NA NA NA hsa-miR-192-5p PDP1 -0.50188499512787 0.00344713341196035 -0.55248328428444 0.00829430941999616 MirTarget -0.458563186270701 1.57682601421953e-15 NA NA NA hsa-miR-30b-5p PDPR -0.54056186708617 2.44688760798341e-05 0.147145655804702 0.33723232381781 mirMAP -0.169798909871703 0.00339739752613305 NA NA NA hsa-miR-29c-3p PDRG1 -1.4367517608807 1.61767774905781e-21 0.749420157972959 2.61864495045724e-15 MirTarget -0.256695307373053 6.05828376895453e-19 NA NA NA hsa-miR-181a-5p PDXDC1 0.250113435902954 0.0551933249319293 -0.618637369600821 4.64277780662657e-11 MirTarget -0.209825334692871 3.15474415690046e-09 NA NA NA hsa-miR-181b-5p PDXDC1 0.488256489401108 0.00105321129419701 -0.618637369600821 4.64277780662657e-11 MirTarget -0.209178404402996 8.18676228090527e-12 NA NA NA hsa-miR-222-3p PDXDC1 1.08574156066353 1.76407192348131e-11 -0.618637369600821 4.64277780662657e-11 miRNAWalker2_validate -0.235801448253328 4.29076293913904e-18 NA NA NA hsa-miR-27b-3p PDXK -0.823491817819754 9.20935302746823e-14 0.60795962520192 3.81588352286127e-09 miRNATAP -0.120075908333961 0.00788884207825353 NA NA NA hsa-miR-29c-3p PDXK -1.4367517608807 1.61767774905781e-21 0.60795962520192 3.81588352286127e-09 mirMAP -0.134794140304081 2.65043705756603e-05 NA NA NA hsa-miR-146b-5p PDZD2 0.419719546795449 0.0457375823220155 0.614576516910267 0.000550427143916576 miRanda -0.172754582714662 2.745129510123e-05 NA NA NA hsa-miR-455-5p PDZD2 -0.270546034117157 0.0581320703577731 0.614576516910267 0.000550427143916576 miRanda -0.226447329191515 0.000204635321325453 NA NA NA hsa-miR-455-5p PDZK1IP1 -0.270546034117157 0.0581320703577731 1.23114352633079 0.0236227314463087 miRanda -0.628621804044907 0.000735236239357388 NA NA NA hsa-miR-34a-5p PDZRN3 1.03694231790865 5.74864019540594e-14 -2.10033696492655 4.96718436746736e-10 miRNATAP -0.531125304194871 6.30597293436728e-06 NA NA NA hsa-miR-148a-3p PEA15 -0.748702855596996 3.93313343865641e-07 1.12311402840601 1.26777023794476e-31 MirTarget -0.164965212390181 8.2875656209855e-07 NA NA NA hsa-miR-455-3p PEA15 -1.3998033821095 5.72010709806871e-17 1.12311402840601 1.26777023794476e-31 miRNATAP -0.136117127544038 2.24959862536088e-06 NA NA NA hsa-miR-222-3p PEBP1 1.08574156066353 1.76407192348131e-11 -0.878608443206359 1.29047964027122e-09 miRNAWalker2_validate -0.335554267850001 1.61800153583977e-15 NA NA NA hsa-miR-34a-5p PEG10 1.03694231790865 5.74864019540594e-14 1.32430694329515 0.0306146820128554 miRNATAP -0.861404863518407 3.95325340286194e-05 NA NA NA hsa-miR-194-5p PELI1 -0.292530160992458 0.0996141384876663 -0.450193346737121 0.00196515483122718 miRNATAP -0.206737840675787 1.78909520742131e-07 NA NA NA hsa-miR-15a-5p PELI2 0.349521211668244 0.000770735998804736 -2.22288317422522 4.36031500280464e-22 miRNATAP -0.477926622365372 2.58676709668138e-05 NA NA NA hsa-miR-17-3p PELI2 0.410352776142368 0.00422200500748636 -2.22288317422522 4.36031500280464e-22 miRNATAP -0.402977360361535 7.98807552353822e-07 NA NA NA hsa-miR-222-3p PELI2 1.08574156066353 1.76407192348131e-11 -2.22288317422522 4.36031500280464e-22 miRNAWalker2_validate -0.189580721488993 0.00809003823704425 NA NA NA hsa-miR-181a-5p PER2 0.250113435902954 0.0551933249319293 -0.671467371709996 2.18508455717704e-08 MirTarget;miRNATAP -0.178149088324459 9.02436131658272e-05 NA NA NA hsa-miR-181b-5p PER2 0.488256489401108 0.00105321129419701 -0.671467371709996 2.18508455717704e-08 MirTarget -0.186511272683123 2.21976238415635e-06 NA NA NA hsa-miR-21-5p PER2 1.51084295924322 1.54551622173259e-34 -0.671467371709996 2.18508455717704e-08 MirTarget -0.31016960095489 7.92967821787459e-13 NA NA NA hsa-miR-181a-5p PER3 0.250113435902954 0.0551933249319293 -0.848602701375337 1.12316239584011e-06 MirTarget -0.234406078327402 0.000382577486272257 NA NA NA hsa-miR-181b-5p PER3 0.488256489401108 0.00105321129419701 -0.848602701375337 1.12316239584011e-06 MirTarget -0.295446922785539 2.09694736313518e-07 NA NA NA hsa-miR-21-5p PER3 1.51084295924322 1.54551622173259e-34 -0.848602701375337 1.12316239584011e-06 miRNAWalker2_validate -0.495600144148107 1.73737178564388e-15 NA NA NA hsa-miR-221-3p PEX1 1.12244756358612 3.48370308238012e-13 -0.293374407449564 0.0109875123548264 miRNAWalker2_validate -0.14198576420168 5.72115861711408e-05 NA NA NA hsa-miR-15a-5p PEX12 0.349521211668244 0.000770735998804736 -0.335738177428607 0.00165333863422164 MirTarget -0.18838208935507 0.000172745402785951 NA NA NA hsa-miR-15a-5p PEX13 0.349521211668244 0.000770735998804736 -0.769268840850009 9.78077692825193e-28 MirTarget -0.15810015563187 6.47255743738234e-06 NA NA NA hsa-miR-221-3p PEX19 1.12244756358612 3.48370308238012e-13 -0.223033990954226 0.0244750913396949 miRNAWalker2_validate -0.117045200308747 0.000111562529685485 NA NA NA hsa-miR-192-5p PFKFB2 -0.50188499512787 0.00344713341196035 1.02845639301179 4.08475002850898e-12 mirMAP -0.112331651767296 0.00926130538928353 NA NA NA hsa-miR-30b-5p PFKFB2 -0.54056186708617 2.44688760798341e-05 1.02845639301179 4.08475002850898e-12 mirMAP -0.195258874847819 0.000692144399164844 NA NA NA hsa-miR-30e-5p PFKFB2 -0.627815042856657 3.02205690184908e-10 1.02845639301179 4.08475002850898e-12 mirMAP -0.161767375405626 0.0281343484611033 NA NA NA hsa-miR-192-3p PFKFB3 -0.6401165114007 0.000266272092403814 -1.30750392590811 6.72544029163249e-08 mirMAP -0.501310040676497 2.99942782290446e-14 NA NA NA hsa-miR-19b-3p PFKFB3 0.601279551368824 0.00016685097085251 -1.30750392590811 6.72544029163249e-08 miRNATAP -0.20145600237314 0.00703849002427659 NA NA NA hsa-miR-20a-5p PFKFB3 0.854326758727003 5.04256669663285e-07 -1.30750392590811 6.72544029163249e-08 MirTarget -0.271681350187159 9.01121015520368e-05 NA NA NA hsa-miR-30b-5p PFKFB4 -0.54056186708617 2.44688760798341e-05 1.25161751152843 3.78691544751763e-10 mirMAP -0.193397018917018 0.0125230719303459 NA NA NA hsa-miR-30e-5p PFKFB4 -0.627815042856657 3.02205690184908e-10 1.25161751152843 3.78691544751763e-10 mirMAP -0.305461964382377 0.00194077086133083 NA NA NA hsa-miR-27b-3p PFKM -0.823491817819754 9.20935302746823e-14 0.138045606565713 0.433467052903604 MirTarget -0.421756812414256 1.64470387651258e-08 NA NA NA hsa-miR-20a-5p PFKP 0.854326758727003 5.04256669663285e-07 0.709669274361661 0.00796476514189581 MirTarget -0.268242425315447 0.000398143638122438 NA NA NA hsa-miR-455-3p PFKP -1.3998033821095 5.72010709806871e-17 0.709669274361661 0.00796476514189581 miRNAWalker2_validate -0.602737589358301 9.89569079858249e-17 NA NA NA hsa-miR-30c-5p PFN1 -0.432111642767632 0.000159764714931007 -0.130096331004149 0.165623501781936 miRNAWalker2_validate -0.159895792448685 5.41671760811874e-05 NA NA NA hsa-miR-194-5p PFN2 -0.292530160992458 0.0996141384876663 -1.30384490866722 4.73283772543551e-07 miRNATAP -0.441920192028256 4.19644133094824e-10 NA NA NA hsa-miR-20a-5p PFN2 0.854326758727003 5.04256669663285e-07 -1.30384490866722 4.73283772543551e-07 miRNATAP -0.152671827589902 0.0404006927595731 NA NA NA hsa-miR-30b-5p PGAP1 -0.54056186708617 2.44688760798341e-05 0.012333141833667 0.926382513383674 mirMAP -0.135369037090845 0.00729023882405391 NA NA NA hsa-miR-29c-3p PGAP2 -1.4367517608807 1.61767774905781e-21 0.175128352783613 0.0409029209446004 miRNATAP -0.119999703569166 4.11113280187186e-06 NA NA NA hsa-miR-20a-5p PGK1 0.854326758727003 5.04256669663285e-07 0.216934441634805 0.0428574353274189 miRNAWalker2_validate -0.150883278607544 4.81198111338975e-07 NA NA NA hsa-miR-15a-5p PGM1 0.349521211668244 0.000770735998804736 -1.40075825600012 2.10976465428731e-23 MirTarget -0.181992571466715 0.00933931526482135 NA NA NA hsa-miR-30b-5p PGM1 -0.54056186708617 2.44688760798341e-05 -1.40075825600012 2.10976465428731e-23 MirTarget -0.142521316681333 0.0114227788304973 NA NA NA hsa-miR-30b-5p PGM2 -0.54056186708617 2.44688760798341e-05 -0.619661718978993 0.000185463023478244 MirTarget -0.142395452863709 0.0244932500616765 NA NA NA hsa-miR-15a-5p PGM2L1 0.349521211668244 0.000770735998804736 0.0325808937730736 0.823878768591522 miRNATAP -0.158085869150469 0.0217159386403733 NA NA NA hsa-miR-19b-3p PGM2L1 0.601279551368824 0.00016685097085251 0.0325808937730736 0.823878768591522 miRNATAP -0.115838452906726 0.00903288660110904 NA NA NA hsa-miR-20a-5p PGM2L1 0.854326758727003 5.04256669663285e-07 0.0325808937730736 0.823878768591522 MirTarget;miRNATAP -0.140349823227095 0.000670544685701233 NA NA NA hsa-miR-27b-3p PGM2L1 -0.823491817819754 9.20935302746823e-14 0.0325808937730736 0.823878768591522 miRNATAP -0.234323502588402 0.000184297638644297 NA NA NA hsa-miR-30b-5p PGM3 -0.54056186708617 2.44688760798341e-05 -0.337625063501097 0.00318971196135641 miRNAWalker2_validate;MirTarget -0.180322090655738 2.9935379771561e-05 NA NA NA hsa-miR-132-3p PGPEP1 0.323796239695997 0.00272093067935091 0.167322965185669 0.143077647806586 mirMAP -0.208990326324965 4.78918779924388e-05 NA NA NA hsa-miR-181a-5p PGPEP1 0.250113435902954 0.0551933249319293 0.167322965185669 0.143077647806586 mirMAP -0.163349239649513 0.000125269843842886 NA NA NA hsa-miR-181b-5p PGPEP1 0.488256489401108 0.00105321129419701 0.167322965185669 0.143077647806586 mirMAP -0.150383497544233 4.829363611668e-05 NA NA NA hsa-miR-29c-3p PGPEP1 -1.4367517608807 1.61767774905781e-21 0.167322965185669 0.143077647806586 mirMAP -0.107698184701159 0.00211184603097798 NA NA NA hsa-miR-30b-5p PGPEP1 -0.54056186708617 2.44688760798341e-05 0.167322965185669 0.143077647806586 mirMAP -0.118697291438324 0.00599972296763821 NA NA NA hsa-miR-17-3p PGR 0.410352776142368 0.00422200500748636 -2.1793358458203 1.59838886951673e-10 mirMAP -0.625329517709588 9.16471561013809e-08 NA NA NA hsa-miR-192-5p PGR -0.50188499512787 0.00344713341196035 -2.1793358458203 1.59838886951673e-10 mirMAP -0.423797559048497 1.58785226195653e-05 NA NA NA hsa-miR-20a-5p PGR 0.854326758727003 5.04256669663285e-07 -2.1793358458203 1.59838886951673e-10 mirMAP -0.672733226493956 2.97305308992447e-12 NA NA NA hsa-miR-224-3p PGR 1.40770116795301 1.31426607144612e-08 -2.1793358458203 1.59838886951673e-10 mirMAP -0.150918317620471 0.0273060045541296 NA NA NA hsa-miR-181a-5p PGRMC2 0.250113435902954 0.0551933249319293 -0.34369815717862 7.20024903580005e-05 mirMAP -0.21440180579755 1.76762726139047e-11 NA NA NA hsa-miR-181b-5p PGRMC2 0.488256489401108 0.00105321129419701 -0.34369815717862 7.20024903580005e-05 mirMAP -0.223407583525163 3.46415940006866e-16 NA NA NA hsa-miR-21-5p PGRMC2 1.51084295924322 1.54551622173259e-34 -0.34369815717862 7.20024903580005e-05 miRNAWalker2_validate -0.181193895693892 6.43859631847864e-09 NA NA NA hsa-miR-30e-5p PHACTR1 -0.627815042856657 3.02205690184908e-10 0.520006432721148 0.00360065562458295 mirMAP -0.249580184058242 0.00393001443128084 NA NA NA hsa-miR-455-5p PHACTR1 -0.270546034117157 0.0581320703577731 0.520006432721148 0.00360065562458295 miRNATAP -0.209069409806311 0.00063370642307231 NA NA NA hsa-miR-21-5p PHACTR2 1.51084295924322 1.54551622173259e-34 -0.74980974150153 3.84085236018818e-07 miRNAWalker2_validate -0.139329194785773 0.0107368595820114 NA NA NA hsa-miR-181a-5p PHACTR4 0.250113435902954 0.0551933249319293 -0.269981995883152 0.000685262779050799 MirTarget -0.118791784784413 6.30944814003686e-05 NA NA NA hsa-miR-181b-5p PHACTR4 0.488256489401108 0.00105321129419701 -0.269981995883152 0.000685262779050799 MirTarget -0.109656457148818 2.12851709036252e-05 NA NA NA hsa-miR-192-5p PHF19 -0.50188499512787 0.00344713341196035 1.31515412555065 1.20077313718174e-18 miRNAWalker2_validate -0.222092476769903 3.69245912036561e-07 NA NA NA hsa-miR-30c-5p PHF20L1 -0.432111642767632 0.000159764714931007 0.386162581991988 8.19163052877354e-06 mirMAP -0.128537662285613 0.000514272315447397 NA NA NA hsa-miR-30e-5p PHF20L1 -0.627815042856657 3.02205690184908e-10 0.386162581991988 8.19163052877354e-06 mirMAP -0.125253594016757 0.00290473387867998 NA NA NA hsa-miR-192-3p PHF21A -0.6401165114007 0.000266272092403814 0.536739369729245 3.79383887055722e-09 mirMAP -0.196129545269971 2.14489312317617e-15 NA NA NA hsa-miR-192-5p PHF21A -0.50188499512787 0.00344713341196035 0.536739369729245 3.79383887055722e-09 mirMAP -0.186935978648832 2.3371831640115e-13 NA NA NA hsa-miR-27b-3p PHF21A -0.823491817819754 9.20935302746823e-14 0.536739369729245 3.79383887055722e-09 mirMAP -0.192230089570725 1.10894919490395e-06 NA NA NA hsa-miR-29c-3p PHF21A -1.4367517608807 1.61767774905781e-21 0.536739369729245 3.79383887055722e-09 MirTarget -0.170070465611221 1.19673538827132e-09 NA NA NA hsa-miR-505-5p PHF21A -0.768282569967001 1.14662846595407e-05 0.536739369729245 3.79383887055722e-09 mirMAP -0.158687411931093 2.31500464084512e-10 NA NA NA hsa-miR-30b-5p PHF6 -0.54056186708617 2.44688760798341e-05 0.503247405177014 4.63112158573096e-07 mirMAP -0.106362281101849 0.00540369777637545 NA NA NA hsa-miR-15a-5p PHKB 0.349521211668244 0.000770735998804736 -0.182840542049965 0.0604027724644025 miRNAWalker2_validate -0.154882050990863 0.000688424431399183 NA NA NA hsa-miR-181a-5p PHKG2 0.250113435902954 0.0551933249319293 0.0670569896420519 0.461670030596112 mirMAP -0.102640870596757 0.00252224837408455 NA NA NA hsa-miR-181b-5p PHKG2 0.488256489401108 0.00105321129419701 0.0670569896420519 0.461670030596112 mirMAP -0.112966880008944 0.000125745640576018 NA NA NA hsa-miR-19b-3p PHLDA1 0.601279551368824 0.00016685097085251 -2.61421375107065 3.80667249002625e-32 mirMAP -0.397556667000906 3.13168831282753e-08 NA NA NA hsa-miR-19b-3p PHLDA3 0.601279551368824 0.00016685097085251 0.589620691840005 0.0396907231401655 MirTarget -0.225069121050948 0.00986301713656258 NA NA NA hsa-miR-15a-5p PHLPP2 0.349521211668244 0.000770735998804736 -0.0462325263383927 0.691559726183747 MirTarget;miRNATAP -0.113585470877751 0.0382145296269402 NA NA NA hsa-miR-19b-3p PHLPP2 0.601279551368824 0.00016685097085251 -0.0462325263383927 0.691559726183747 mirMAP -0.233031999669343 1.39406664489008e-11 NA NA NA hsa-miR-20a-5p PHLPP2 0.854326758727003 5.04256669663285e-07 -0.0462325263383927 0.691559726183747 miRNATAP -0.267319009474098 3.22360794507594e-17 NA NA NA hsa-miR-27b-3p PHLPP2 -0.823491817819754 9.20935302746823e-14 -0.0462325263383927 0.691559726183747 MirTarget;miRNATAP -0.140894596676105 0.00484377792767415 NA NA NA hsa-miR-192-5p PHTF1 -0.50188499512787 0.00344713341196035 -0.0638230799417907 0.575687988687985 miRNAWalker2_validate -0.161998655473504 3.67704204137034e-07 NA NA NA hsa-miR-192-5p PHTF2 -0.50188499512787 0.00344713341196035 0.479833616664147 1.04897601040811e-06 miRNAWalker2_validate -0.18439724972846 2.03367562069468e-11 NA NA NA hsa-miR-30e-5p PHTF2 -0.627815042856657 3.02205690184908e-10 0.479833616664147 1.04897601040811e-06 MirTarget -0.151849021691288 0.00151691588088645 NA NA NA hsa-miR-20a-5p PHYHIP 0.854326758727003 5.04256669663285e-07 -0.612790074176789 0.0083593891744158 miRNATAP -0.243012272447005 0.000219193011615353 NA NA NA hsa-miR-182-5p PHYHIPL 1.96601340710222 4.39326175603633e-09 0.875425421453594 0.00299276786748856 miRNATAP -0.12616416414718 0.00276532356135566 NA NA NA hsa-miR-19b-3p PI15 0.601279551368824 0.00016685097085251 2.42014798732433 5.6014711887512e-09 MirTarget -0.253807959284323 0.0488361123531644 NA NA NA hsa-miR-29c-3p PI15 -1.4367517608807 1.61767774905781e-21 2.42014798732433 5.6014711887512e-09 MirTarget;miRNATAP -0.448293342300607 0.000558671181580667 NA NA NA hsa-miR-455-5p PI15 -0.270546034117157 0.0581320703577731 2.42014798732433 5.6014711887512e-09 miRNATAP -0.498368521789904 0.000564278283331077 NA NA NA hsa-miR-181a-5p PI4K2B 0.250113435902954 0.0551933249319293 -0.759829344931532 1.35039006281556e-09 MirTarget;miRNATAP -0.398305655058553 5.26185792401661e-18 NA NA NA hsa-miR-181b-5p PI4K2B 0.488256489401108 0.00105321129419701 -0.759829344931532 1.35039006281556e-09 MirTarget;miRNATAP -0.412772797118688 7.13930402934494e-26 NA NA NA hsa-miR-34a-5p PID1 1.03694231790865 5.74864019540594e-14 -1.13413413905438 3.13755806518741e-11 miRNATAP -0.21963568495015 0.000244231160048844 NA NA NA hsa-miR-192-5p PIF1 -0.50188499512787 0.00344713341196035 2.41082297409356 3.54735544684265e-24 miRNAWalker2_validate -0.172432715063759 0.0159099494489366 NA NA NA hsa-miR-132-3p PIGK 0.323796239695997 0.00272093067935091 -0.291923881998766 0.00135698257670697 MirTarget -0.105772761360613 0.0105726616634454 NA NA NA hsa-miR-30b-5p PIGM -0.54056186708617 2.44688760798341e-05 0.425424412297172 2.73259555683655e-07 mirMAP -0.101891730561082 0.00126589013435026 NA NA NA hsa-miR-30c-5p PIGM -0.432111642767632 0.000159764714931007 0.425424412297172 2.73259555683655e-07 mirMAP -0.11564024249637 0.00113291315743065 NA NA NA hsa-miR-21-5p PIGN 1.51084295924322 1.54551622173259e-34 -0.115796664312666 0.17921793826658 miRNAWalker2_validate -0.134350451621118 1.5560087613616e-05 NA NA NA hsa-miR-222-3p PIGQ 1.08574156066353 1.76407192348131e-11 -0.219387839891756 0.0346070227254521 miRNAWalker2_validate -0.12292887050893 5.30140511909415e-05 NA NA NA hsa-miR-132-3p PIGY 0.323796239695997 0.00272093067935091 -0.281447693839949 0.000443273542430731 MirTarget -0.248197156572507 2.60873263756318e-12 NA NA NA hsa-miR-21-5p PIK3C2A 1.51084295924322 1.54551622173259e-34 -0.190979416238561 0.0562063266883107 miRNAWalker2_validate -0.178042173346167 7.80247659980854e-07 NA NA NA hsa-miR-455-3p PIK3C2B -1.3998033821095 5.72010709806871e-17 0.902726755526454 2.91031962163582e-12 mirMAP -0.110477691993362 0.00297873699660576 NA NA NA hsa-miR-30e-5p PIK3CD -0.627815042856657 3.02205690184908e-10 -0.877858532886072 2.39332269929579e-06 MirTarget -0.253648851782905 0.00528999528593308 NA NA NA hsa-miR-148a-3p PIK3IP1 -0.748702855596996 3.93313343865641e-07 0.504536960127542 0.00150104183804736 MirTarget -0.412399483927594 2.45708221476412e-16 NA NA NA hsa-miR-132-3p PIK3R1 0.323796239695997 0.00272093067935091 -0.891953424131491 1.38465728969785e-08 MirTarget -0.517351445825174 2.17222827385203e-13 NA NA NA hsa-miR-20a-5p PIK3R1 0.854326758727003 5.04256669663285e-07 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.137431012149634 0.00237710222818209 NA NA NA hsa-miR-21-5p PIK3R1 1.51084295924322 1.54551622173259e-34 -0.891953424131491 1.38465728969785e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.626634426633867 6.01244523464713e-31 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-221-3p PIK3R1 1.12244756358612 3.48370308238012e-13 -0.891953424131491 1.38465728969785e-08 MirTarget -0.217914846238424 7.87055620620445e-06 NA NA NA hsa-miR-222-3p PIK3R1 1.08574156066353 1.76407192348131e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.256619417997498 3.41697791848384e-08 NA NA NA hsa-miR-409-3p PIK3R1 -0.499649792570937 0.0526751181520117 -0.891953424131491 1.38465728969785e-08 mirMAP -0.110448878014769 0.000237041711390918 NA NA NA hsa-miR-30e-5p PIK3R2 -0.627815042856657 3.02205690184908e-10 0.902461657566753 1.95242785807378e-14 miRNATAP -0.27051427660089 3.48529317139267e-06 NA NA NA hsa-miR-19b-3p PIK3R3 0.601279551368824 0.00016685097085251 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.156884173334155 7.42851910353984e-06 NA NA NA hsa-miR-21-5p PIKFYVE 1.51084295924322 1.54551622173259e-34 -0.360642566218591 0.00157442514854895 MirTarget -0.251222573601493 8.81825641630044e-10 NA NA NA hsa-miR-194-5p PIP4K2A -0.292530160992458 0.0996141384876663 -0.358701408306054 0.000429638184864051 MirTarget -0.191518801871381 2.67414996939188e-12 NA NA NA hsa-miR-181a-5p PITPNC1 0.250113435902954 0.0551933249319293 0.167033920726064 0.20212856268457 mirMAP -0.297891278041169 6.14659481410513e-10 NA NA NA hsa-miR-181b-5p PITPNC1 0.488256489401108 0.00105321129419701 0.167033920726064 0.20212856268457 mirMAP -0.276332092271579 3.61656786920082e-11 NA NA NA hsa-miR-30b-5p PITPNC1 -0.54056186708617 2.44688760798341e-05 0.167033920726064 0.20212856268457 MirTarget;mirMAP -0.129476468453526 0.00897331953167021 NA NA NA hsa-miR-221-3p PITPNM2 1.12244756358612 3.48370308238012e-13 0.252057635121367 0.0799674757736623 MirTarget -0.120283319820245 0.00652412301490194 NA NA NA hsa-miR-222-3p PITPNM2 1.08574156066353 1.76407192348131e-11 0.252057635121367 0.0799674757736623 MirTarget -0.139396875702707 0.000994118144732389 NA NA NA hsa-miR-432-5p PITPNM2 -0.536178819038888 0.0748623258271085 0.252057635121367 0.0799674757736623 mirMAP -0.133558228696803 6.1570239158225e-09 NA NA NA hsa-miR-148a-3p PITPNM3 -0.748702855596996 3.93313343865641e-07 -3.87084899319612 7.38035528475542e-40 mirMAP -0.339199491738163 0.00130873355554756 NA NA NA hsa-miR-15a-5p PITPNM3 0.349521211668244 0.000770735998804736 -3.87084899319612 7.38035528475542e-40 MirTarget -0.711723734810007 2.47154645154456e-06 NA NA NA hsa-miR-192-3p PITPNM3 -0.6401165114007 0.000266272092403814 -3.87084899319612 7.38035528475542e-40 mirMAP -0.39541093167741 8.3223602739249e-06 NA NA NA hsa-miR-30c-5p PITX1 -0.432111642767632 0.000159764714931007 4.07775096376809 6.48992389749092e-14 mirMAP;miRNATAP -0.792852254949816 0.000898522203968479 NA NA NA hsa-miR-30e-5p PITX1 -0.627815042856657 3.02205690184908e-10 4.07775096376809 6.48992389749092e-14 mirMAP -1.51516989976955 1.47823133978758e-08 NA NA NA hsa-miR-455-3p PITX1 -1.3998033821095 5.72010709806871e-17 4.07775096376809 6.48992389749092e-14 PITA;miRNATAP -0.877359776686177 1.61728963889996e-08 NA NA NA hsa-miR-146b-5p PIWIL4 0.419719546795449 0.0457375823220155 -0.279411101020563 0.30131293134223 miRanda -0.142893562530412 0.0226689923990282 NA NA NA hsa-miR-181b-5p PJA2 0.488256489401108 0.00105321129419701 -0.547154205949659 1.53194178694233e-08 mirMAP -0.182737048802674 6.7852682384658e-09 NA NA NA hsa-miR-21-5p PJA2 1.51084295924322 1.54551622173259e-34 -0.547154205949659 1.53194178694233e-08 MirTarget -0.246478997567002 1.64079176744364e-12 NA NA NA hsa-miR-455-5p PJA2 -0.270546034117157 0.0581320703577731 -0.547154205949659 1.53194178694233e-08 MirTarget;PITA;miRanda;miRNATAP -0.100799712571601 0.00266422054663171 NA NA NA hsa-miR-194-5p PKD2 -0.292530160992458 0.0996141384876663 -0.661271085670887 4.60860116109786e-05 miRNATAP -0.352354629206693 4.66761862842885e-16 NA NA NA hsa-miR-20a-5p PKD2 0.854326758727003 5.04256669663285e-07 -0.661271085670887 4.60860116109786e-05 MirTarget;miRNATAP -0.370799761416449 1.04110265083866e-16 NA NA NA hsa-miR-224-3p PKHD1 1.40770116795301 1.31426607144612e-08 -2.53067756599261 9.38995240519848e-10 mirMAP -0.189514451961853 0.022101352626283 NA NA NA hsa-miR-27b-3p PKIA -0.823491817819754 9.20935302746823e-14 0.259803934002916 0.404559580397709 MirTarget;miRNATAP -0.484500368486809 0.000290869590531062 NA NA NA hsa-miR-34a-5p PKIA 1.03694231790865 5.74864019540594e-14 0.259803934002916 0.404559580397709 MirTarget;miRNATAP -0.36180824116918 0.000697405939351095 NA NA NA hsa-miR-192-5p PKP1 -0.50188499512787 0.00344713341196035 0.100017778193532 0.757646246120147 mirMAP -0.417541080148801 4.50419320208487e-06 NA NA NA hsa-miR-455-3p PKP1 -1.3998033821095 5.72010709806871e-17 0.100017778193532 0.757646246120147 mirMAP -0.238956730853983 0.00854980203285939 NA NA NA hsa-miR-222-3p PKP2 1.08574156066353 1.76407192348131e-11 -0.937292077636494 1.04765575099144e-05 miRNAWalker2_validate -0.273784527970294 1.35414875681537e-05 NA NA NA hsa-miR-181a-5p PLA2G12A 0.250113435902954 0.0551933249319293 -0.791023748042462 1.18231931629012e-15 mirMAP -0.193778811048191 3.19565578842397e-07 NA NA NA hsa-miR-181b-5p PLA2G12A 0.488256489401108 0.00105321129419701 -0.791023748042462 1.18231931629012e-15 mirMAP -0.187398478397273 1.16778168992629e-08 NA NA NA hsa-miR-20a-5p PLA2G12A 0.854326758727003 5.04256669663285e-07 -0.791023748042462 1.18231931629012e-15 mirMAP -0.130236012494097 5.73845333718432e-06 NA NA NA hsa-miR-29c-3p PLAG1 -1.4367517608807 1.61767774905781e-21 1.04276161449411 0.000370375517337123 miRNAWalker2_validate;miRNATAP -0.255153241770635 0.00489378329751096 NA NA NA hsa-miR-30b-5p PLAGL2 -0.54056186708617 2.44688760798341e-05 0.336986331692996 0.00300478705110513 MirTarget;mirMAP -0.104323546494721 0.0156209041080542 NA NA NA hsa-miR-192-5p PLAU -0.50188499512787 0.00344713341196035 0.959311155204742 3.74075251162113e-09 miRNAWalker2_validate -0.53675875465802 1.47466599529483e-35 NA NA NA hsa-miR-215-5p PLAU -0.981544773246509 3.14452272477156e-05 0.959311155204742 3.74075251162113e-09 miRNAWalker2_validate -0.138182697500426 4.24042407566617e-05 NA NA NA hsa-miR-455-3p PLAU -1.3998033821095 5.72010709806871e-17 0.959311155204742 3.74075251162113e-09 miRNATAP -0.378030540894341 3.15780073257729e-17 NA NA NA hsa-miR-34a-5p PLCB1 1.03694231790865 5.74864019540594e-14 1.21243658346715 1.07604080006647e-07 miRNATAP -0.202032428233518 0.0111678174466371 NA NA NA hsa-miR-192-3p PLCB4 -0.6401165114007 0.000266272092403814 0.84042226647322 0.000567827430148375 miRNATAP -0.557224111035552 1.21106381609851e-17 NA NA NA hsa-miR-455-3p PLCD4 -1.3998033821095 5.72010709806871e-17 0.889540247031085 2.59186315053718e-09 miRNATAP -0.103450655786951 0.0154923144950273 NA NA NA hsa-miR-192-5p PLCE1 -0.50188499512787 0.00344713341196035 1.83443085070885 1.01603163205123e-17 miRNAWalker2_validate -0.326507983373389 1.74795253782827e-07 NA NA NA hsa-miR-215-5p PLCE1 -0.981544773246509 3.14452272477156e-05 1.83443085070885 1.01603163205123e-17 miRNAWalker2_validate -0.116910535149275 0.0105375816716153 NA NA NA hsa-miR-194-5p PLCH1 -0.292530160992458 0.0996141384876663 0.0445092939373148 0.875351483156071 miRNATAP -0.201616035154915 0.00962747189269129 NA NA NA hsa-miR-455-5p PLCH1 -0.270546034117157 0.0581320703577731 0.0445092939373148 0.875351483156071 miRanda -0.368195311518896 0.000138400031061819 NA NA NA hsa-miR-455-3p PLCH2 -1.3998033821095 5.72010709806871e-17 0.579752893837445 0.126241006407986 mirMAP -0.303708785909675 0.00430171419295784 NA NA NA hsa-miR-181a-5p PLCL2 0.250113435902954 0.0551933249319293 -0.522483808057969 0.00170145019411227 miRNAWalker2_validate;miRNATAP -0.143747368642208 0.0220768566500228 NA NA NA hsa-miR-181b-5p PLCL2 0.488256489401108 0.00105321129419701 -0.522483808057969 0.00170145019411227 miRNATAP -0.190909979212524 0.000448662867766351 NA NA NA hsa-miR-15a-5p PLD1 0.349521211668244 0.000770735998804736 -1.16313063789315 9.80903873525724e-10 MirTarget -0.380401161220259 2.87100002980444e-05 NA NA NA hsa-miR-15a-5p PLEKHA1 0.349521211668244 0.000770735998804736 -0.551113202524991 2.34631688636684e-09 MirTarget;miRNATAP -0.146110637725175 0.000918374370721114 NA NA NA hsa-miR-21-5p PLEKHA1 1.51084295924322 1.54551622173259e-34 -0.551113202524991 2.34631688636684e-09 miRNAWalker2_validate;MirTarget;miRNATAP -0.18932877131577 1.98834273745768e-08 NA NA NA hsa-miR-17-3p PLEKHA2 0.410352776142368 0.00422200500748636 -0.969562161830209 1.2701299627881e-11 mirMAP -0.101910682031816 0.0414209845958635 NA NA NA hsa-miR-19b-3p PLEKHA2 0.601279551368824 0.00016685097085251 -0.969562161830209 1.2701299627881e-11 mirMAP -0.102582767044916 0.0215231787973102 NA NA NA hsa-miR-20a-5p PLEKHA2 0.854326758727003 5.04256669663285e-07 -0.969562161830209 1.2701299627881e-11 mirMAP -0.130098561168356 0.0017227130047032 NA NA NA hsa-miR-181a-5p PLEKHA3 0.250113435902954 0.0551933249319293 -0.403395146399148 1.65329256934451e-07 MirTarget -0.208349692533991 2.1842324606592e-13 NA NA NA hsa-miR-181b-5p PLEKHA3 0.488256489401108 0.00105321129419701 -0.403395146399148 1.65329256934451e-07 MirTarget -0.181059458183546 2.31339698175958e-13 NA NA NA hsa-miR-20a-5p PLEKHA3 0.854326758727003 5.04256669663285e-07 -0.403395146399148 1.65329256934451e-07 MirTarget -0.159692015497215 8.83759148098903e-14 NA NA NA hsa-miR-148a-3p PLEKHB2 -0.748702855596996 3.93313343865641e-07 0.00560086814314076 0.957822592701461 MirTarget -0.38563730310529 6.3296530559203e-34 NA NA NA hsa-miR-19b-3p PLEKHG1 0.601279551368824 0.00016685097085251 -0.598437911901986 1.29008369603334e-05 mirMAP -0.149653410282609 0.000354411450307581 NA NA NA hsa-miR-192-5p PLEKHG2 -0.50188499512787 0.00344713341196035 1.10126051664067 3.21863245758859e-16 miRNAWalker2_validate -0.286918579075941 9.78124593620595e-14 NA NA NA hsa-miR-27b-3p PLEKHH1 -0.823491817819754 9.20935302746823e-14 1.25039195218202 7.83074573807631e-12 miRNATAP -0.469231159638081 3.56029835326662e-09 NA NA NA hsa-miR-146b-5p PLEKHH2 0.419719546795449 0.0457375823220155 -1.10251040690662 0.000133768249654324 miRanda;miRNATAP -0.145831701473368 0.0307893977707427 NA NA NA hsa-miR-27b-3p PLEKHJ1 -0.823491817819754 9.20935302746823e-14 0.462053181192892 6.74000515110976e-05 miRNATAP -0.110826200534401 0.0276342009771135 NA NA NA hsa-miR-20a-5p PLEKHM1 0.854326758727003 5.04256669663285e-07 -0.0220349253822141 0.762787471995565 MirTarget;miRNATAP -0.123971374860899 7.65950112554812e-10 NA NA NA hsa-miR-455-3p PLEKHM2 -1.3998033821095 5.72010709806871e-17 0.3976800949126 1.52438429298036e-07 miRNAWalker2_validate -0.111130384541885 1.58234447808898e-07 NA NA NA hsa-miR-20a-5p PLEKHM3 0.854326758727003 5.04256669663285e-07 -0.44092979439459 0.000176550137879797 miRNAWalker2_validate;MirTarget -0.11653447948224 0.000479658943226706 NA NA NA hsa-miR-20a-5p PLEKHO2 0.854326758727003 5.04256669663285e-07 -0.28499524807241 0.0207483976175056 MirTarget;miRNATAP -0.118000868708978 0.000702836197642093 NA NA NA hsa-miR-30c-5p PLEKHO2 -0.432111642767632 0.000159764714931007 -0.28499524807241 0.0207483976175056 MirTarget -0.11161200353684 0.0338105911342418 NA NA NA hsa-miR-30e-5p PLEKHO2 -0.627815042856657 3.02205690184908e-10 -0.28499524807241 0.0207483976175056 MirTarget -0.263420484518743 8.35027604817618e-06 NA NA NA hsa-miR-455-5p PLEKHO2 -0.270546034117157 0.0581320703577731 -0.28499524807241 0.0207483976175056 miRanda -0.194680581395936 3.2613635985755e-06 NA NA NA hsa-miR-30e-5p PLIN3 -0.627815042856657 3.02205690184908e-10 0.211761460820838 0.0329997103537109 MirTarget -0.230253044915268 1.22024201830348e-06 NA NA NA hsa-miR-505-5p PLK1 -0.768282569967001 1.14662846595407e-05 3.58200503456178 1.01936996392609e-41 MirTarget -0.372253566265304 3.64975232604557e-06 NA NA NA hsa-miR-192-5p PLK4 -0.50188499512787 0.00344713341196035 2.24309967329393 2.25251967570101e-29 miRNAWalker2_validate -0.182298256651921 0.00265855667422409 NA NA NA hsa-miR-215-5p PLK4 -0.981544773246509 3.14452272477156e-05 2.24309967329393 2.25251967570101e-29 miRNAWalker2_validate -0.126905787665991 0.00379889656877864 NA NA NA hsa-miR-181a-5p PLS1 0.250113435902954 0.0551933249319293 -0.343978850494421 0.037888216094636 MirTarget;miRNATAP -0.196235425262314 0.00157938905379615 NA NA NA hsa-miR-181b-5p PLS1 0.488256489401108 0.00105321129419701 -0.343978850494421 0.037888216094636 MirTarget;miRNATAP -0.127817037139185 0.018290923948897 NA NA NA hsa-miR-19b-3p PLS1 0.601279551368824 0.00016685097085251 -0.343978850494421 0.037888216094636 MirTarget -0.166282085483654 0.000933796523567145 NA NA NA hsa-miR-20a-5p PLS1 0.854326758727003 5.04256669663285e-07 -0.343978850494421 0.037888216094636 MirTarget;miRNATAP -0.14356134282351 0.00220626565740312 NA NA NA hsa-miR-20b-5p PLS1 0.457668023910379 0.0285865211936156 -0.343978850494421 0.037888216094636 MirTarget;miRNATAP -0.160613283203149 2.82791517014007e-05 NA NA NA hsa-miR-15a-5p PLSCR4 0.349521211668244 0.000770735998804736 -2.21840265832849 1.26161246830308e-31 MirTarget -0.311004291275862 0.00124938441686673 NA NA NA hsa-miR-20a-5p PLSCR4 0.854326758727003 5.04256669663285e-07 -2.21840265832849 1.26161246830308e-31 MirTarget -0.246445794720824 1.93225822678379e-05 NA NA NA hsa-miR-221-3p PLSCR4 1.12244756358612 3.48370308238012e-13 -2.21840265832849 1.26161246830308e-31 MirTarget -0.415370900712108 1.53717954104031e-11 NA NA NA hsa-miR-222-3p PLSCR4 1.08574156066353 1.76407192348131e-11 -2.21840265832849 1.26161246830308e-31 MirTarget -0.328056468063074 3.76441193167195e-08 NA NA NA hsa-miR-148a-3p PLXDC1 -0.748702855596996 3.93313343865641e-07 2.83957658613902 7.43247270561304e-40 mirMAP -0.883939730974154 2.16067872112889e-35 NA NA NA hsa-miR-194-5p PLXDC1 -0.292530160992458 0.0996141384876663 2.83957658613902 7.43247270561304e-40 mirMAP -0.643520698639128 1.03437834831044e-25 NA NA NA hsa-miR-29c-3p PLXDC1 -1.4367517608807 1.61767774905781e-21 2.83957658613902 7.43247270561304e-40 mirMAP -0.453154178219969 2.50954147228871e-10 NA NA NA hsa-miR-455-3p PLXDC1 -1.3998033821095 5.72010709806871e-17 2.83957658613902 7.43247270561304e-40 mirMAP -0.64064581571937 2.43518508851304e-24 NA NA NA hsa-miR-455-5p PLXDC2 -0.270546034117157 0.0581320703577731 -0.448681905500049 0.0487314725243558 miRanda -0.434998552098239 1.52261897493613e-08 NA NA NA hsa-miR-192-3p PLXNA1 -0.6401165114007 0.000266272092403814 1.2553610589373 5.18036905238032e-15 mirMAP -0.497251217613428 1.39894859042797e-31 NA NA NA hsa-miR-29c-3p PLXNA1 -1.4367517608807 1.61767774905781e-21 1.2553610589373 5.18036905238032e-15 MirTarget;miRNATAP -0.406695867065937 1.57130231018454e-16 NA NA NA hsa-miR-30c-5p PLXNA2 -0.432111642767632 0.000159764714931007 0.670712916849495 3.85732284396182e-10 MirTarget;mirMAP;miRNATAP -0.176577691328417 0.000138608081896572 NA NA NA hsa-miR-30e-5p PLXNA2 -0.627815042856657 3.02205690184908e-10 0.670712916849495 3.85732284396182e-10 MirTarget -0.177640375608812 0.000743885174541799 NA NA NA hsa-miR-19b-3p PLXNA4 0.601279551368824 0.00016685097085251 -2.32968209214848 9.4405095513922e-10 miRNATAP -0.362534391434861 0.00211980932297908 NA NA NA hsa-miR-34a-5p PLXNA4 1.03694231790865 5.74864019540594e-14 -2.32968209214848 9.4405095513922e-10 mirMAP -0.50329341172522 0.000154460250184565 NA NA NA hsa-miR-30b-5p PLXNC1 -0.54056186708617 2.44688760798341e-05 1.44759435164552 0.000116169553345041 mirMAP -0.75929680559867 8.31304845941328e-08 NA NA NA hsa-miR-455-5p PLXNC1 -0.270546034117157 0.0581320703577731 1.44759435164552 0.000116169553345041 PITA;miRanda;miRNATAP -0.370865947890466 0.00419733519351219 NA NA NA hsa-miR-27b-3p PLXND1 -0.823491817819754 9.20935302746823e-14 0.69765536803745 4.01395417482674e-09 MirTarget;miRNATAP -0.18938553597424 0.000254784159367628 NA NA NA hsa-miR-15a-5p PMEPA1 0.349521211668244 0.000770735998804736 -0.100015742263655 0.700739861057591 mirMAP -0.530371137330692 1.28820983743842e-05 NA NA NA hsa-miR-192-3p PMEPA1 -0.6401165114007 0.000266272092403814 -0.100015742263655 0.700739861057591 mirMAP -0.661419885758132 3.1941002031372e-22 NA NA NA hsa-miR-19b-3p PMEPA1 0.601279551368824 0.00016685097085251 -0.100015742263655 0.700739861057591 MirTarget;miRNATAP -0.16813254555221 0.0334982570008926 NA NA NA hsa-miR-455-5p PML -0.270546034117157 0.0581320703577731 0.389845452983164 5.53436758838558e-06 miRanda -0.137275514939852 2.82620406051193e-06 NA NA NA hsa-miR-224-3p PNMA2 1.40770116795301 1.31426607144612e-08 -1.85731298394428 7.34390157410046e-11 mirMAP -0.129484654632523 0.0237278295732609 NA NA NA hsa-miR-15a-5p PNMAL2 0.349521211668244 0.000770735998804736 -1.44060027608004 5.08000769629148e-14 MirTarget -0.444021001006679 1.44784373236631e-06 NA NA NA hsa-miR-146b-5p PNPLA4 0.419719546795449 0.0457375823220155 -0.73077585407305 8.93024606858533e-11 miRanda -0.118279885708887 7.98822281542226e-06 NA NA NA hsa-miR-20a-5p PNPO 0.854326758727003 5.04256669663285e-07 -0.728889693924063 7.74532063797697e-08 MirTarget -0.213850211080156 2.65499941117499e-08 NA NA NA hsa-miR-20b-5p PNPO 0.457668023910379 0.0285865211936156 -0.728889693924063 7.74532063797697e-08 MirTarget -0.205390887283424 5.89704696459154e-11 NA NA NA hsa-miR-132-3p PNRC1 0.323796239695997 0.00272093067935091 -1.21276537102405 5.27621253662257e-23 MirTarget -0.118959108314667 0.0433856822599828 NA NA NA hsa-miR-455-5p PODNL1 -0.270546034117157 0.0581320703577731 1.1933239013887 3.41342743294331e-07 miRanda -0.292855030708624 0.000298676987934244 NA NA NA hsa-miR-148a-3p PODXL -0.748702855596996 3.93313343865641e-07 1.44094860371079 1.88695975215765e-18 MirTarget -0.369390838413584 1.61834113480849e-11 NA NA NA hsa-miR-192-5p PODXL -0.50188499512787 0.00344713341196035 1.44094860371079 1.88695975215765e-18 miRNAWalker2_validate -0.297812792140288 4.48715853597399e-10 NA NA NA hsa-miR-27b-3p PODXL -0.823491817819754 9.20935302746823e-14 1.44094860371079 1.88695975215765e-18 mirMAP -0.223584225898895 0.00247322335562612 NA NA NA hsa-miR-148a-3p POFUT2 -0.748702855596996 3.93313343865641e-07 0.257896779627181 0.00304062880467066 mirMAP -0.123524909535533 1.20021947046028e-05 NA NA NA hsa-miR-29c-3p POFUT2 -1.4367517608807 1.61767774905781e-21 0.257896779627181 0.00304062880467066 mirMAP -0.135815050519467 2.87286078566435e-07 NA NA NA hsa-miR-99a-5p POGK -1.51481656384839 3.93230057259529e-14 0.625888080106357 7.94900288255434e-11 miRNAWalker2_validate -0.172399310993225 1.64998914911725e-14 NA NA NA hsa-miR-29c-3p POLE3 -1.4367517608807 1.61767774905781e-21 0.200584684295309 0.00379024799229057 MirTarget -0.144999424635814 2.64314383257237e-12 NA NA NA hsa-miR-455-5p POLK -0.270546034117157 0.0581320703577731 -0.199838030419762 0.0786958222490605 miRanda -0.141596048703318 0.000253548544912933 NA NA NA hsa-miR-17-3p POLR2A 0.410352776142368 0.00422200500748636 -0.409529469796079 1.17354573068042e-05 miRNAWalker2_validate -0.111227121667748 0.000484235073178126 NA NA NA hsa-miR-21-5p POLR3B 1.51084295924322 1.54551622173259e-34 -0.413501114011505 1.11276506966565e-07 miRNAWalker2_validate -0.188714653183677 1.78932901569377e-11 NA NA NA hsa-miR-455-5p POLR3D -0.270546034117157 0.0581320703577731 -0.139731139176389 0.177373822576576 miRanda -0.107215749993274 0.0023974096390574 NA NA NA hsa-miR-222-3p POMGNT1 1.08574156066353 1.76407192348131e-11 0.295858100373697 0.000363764023228817 miRNAWalker2_validate -0.102590085269051 2.53904415619123e-05 NA NA NA hsa-miR-30b-5p PON2 -0.54056186708617 2.44688760798341e-05 0.405257293689411 0.00147835699510172 MirTarget;miRNATAP -0.10081899052325 0.0378339229586882 NA NA NA hsa-miR-30c-5p PON2 -0.432111642767632 0.000159764714931007 0.405257293689411 0.00147835699510172 MirTarget;miRNATAP -0.231615908863066 1.86887168846129e-05 NA NA NA hsa-miR-30e-5p PON2 -0.627815042856657 3.02205690184908e-10 0.405257293689411 0.00147835699510172 MirTarget;miRNATAP -0.314561052857336 2.62096531978363e-07 NA NA NA hsa-miR-455-5p PORCN -0.270546034117157 0.0581320703577731 1.02534714775069 3.36165614457371e-14 miRanda -0.173425149892979 0.000268476293553168 NA NA NA hsa-miR-30c-5p POU2F1 -0.432111642767632 0.000159764714931007 0.0553305736340822 0.699732666585992 miRNAWalker2_validate -0.217831258169122 0.000337233238563762 NA NA NA hsa-miR-192-5p POU2F2 -0.50188499512787 0.00344713341196035 -1.33751623202634 1.7771030308953e-11 mirMAP -0.341125656110109 1.96291965964719e-09 NA NA NA hsa-miR-146a-5p PPARA -0.742958238440575 0.000765983177482633 -0.607171871846345 3.30592576448713e-05 mirMAP -0.171879393970977 7.42755429927351e-08 NA NA NA hsa-miR-181a-5p PPARA 0.250113435902954 0.0551933249319293 -0.607171871846345 3.30592576448713e-05 miRNATAP -0.42666439213697 1.5289865242608e-15 NA NA NA hsa-miR-181b-5p PPARA 0.488256489401108 0.00105321129419701 -0.607171871846345 3.30592576448713e-05 miRNATAP -0.44197902311784 4.35491871601128e-22 NA NA NA hsa-miR-20b-5p PPARA 0.457668023910379 0.0285865211936156 -0.607171871846345 3.30592576448713e-05 miRNATAP -0.114449170707505 0.000830578609960355 NA NA NA hsa-miR-21-5p PPARA 1.51084295924322 1.54551622173259e-34 -0.607171871846345 3.30592576448713e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.393331541274169 5.04548601402031e-14 22244963 In the final integrative analysis of lung cancer related miR-21-targets analysis 24 hub genes were identified by overlap calculation suggesting that miR-21 may play an important role in the development and progression of lung cancer through JAK/STAT signal pathway MAPK signaling pathway Wnt signaling pathway cell cycle PPAR signaling pathway apoptosis pathway and other pathways progression lung cancer hsa-miR-148a-3p PPARD -0.748702855596996 3.93313343865641e-07 0.429452867716368 0.000219062523065951 mirMAP -0.204207537151173 5.78289748261195e-08 NA NA NA hsa-miR-29c-3p PPARD -1.4367517608807 1.61767774905781e-21 0.429452867716368 0.000219062523065951 miRNATAP -0.122368442661711 0.00063748151355122 NA NA NA hsa-miR-19b-3p PPARGC1A 0.601279551368824 0.00016685097085251 -1.91181447721978 1.53762022606371e-08 mirMAP -0.223743537732007 0.0325546996216352 NA NA NA hsa-miR-221-3p PPARGC1A 1.12244756358612 3.48370308238012e-13 -1.91181447721978 1.53762022606371e-08 miRNATAP -0.865804752132837 1.77855991900398e-17 NA NA NA hsa-miR-222-3p PPARGC1A 1.08574156066353 1.76407192348131e-11 -1.91181447721978 1.53762022606371e-08 miRNATAP -0.780790597938095 1.81818525581664e-15 NA NA NA hsa-miR-409-3p PPARGC1A -0.499649792570937 0.0526751181520117 -1.91181447721978 1.53762022606371e-08 PITA -0.13696990156486 0.035169916526159 NA NA NA hsa-miR-181a-5p PPARGC1B 0.250113435902954 0.0551933249319293 -0.171170839113116 0.38344943912292 mirMAP -0.340583021657862 3.05343677859281e-06 NA NA NA hsa-miR-181b-5p PPARGC1B 0.488256489401108 0.00105321129419701 -0.171170839113116 0.38344943912292 mirMAP -0.321195405563286 3.94016241488117e-07 NA NA NA hsa-miR-19b-3p PPARGC1B 0.601279551368824 0.00016685097085251 -0.171170839113116 0.38344943912292 mirMAP -0.233702843432177 8.08195214385918e-05 NA NA NA hsa-miR-20a-5p PPARGC1B 0.854326758727003 5.04256669663285e-07 -0.171170839113116 0.38344943912292 miRNATAP -0.209661765880598 0.000151154852807879 NA NA NA hsa-miR-27b-3p PPARGC1B -0.823491817819754 9.20935302746823e-14 -0.171170839113116 0.38344943912292 mirMAP -0.200915831211865 0.0175340269443675 NA NA NA hsa-miR-409-3p PPARGC1B -0.499649792570937 0.0526751181520117 -0.171170839113116 0.38344943912292 mirMAP -0.106933051512718 0.00383726611227489 NA NA NA hsa-miR-194-5p PPFIBP1 -0.292530160992458 0.0996141384876663 -0.744896314834953 1.63767150832481e-10 MirTarget -0.136767786122332 2.54700159023465e-05 NA NA NA hsa-miR-19b-3p PPFIBP1 0.601279551368824 0.00016685097085251 -0.744896314834953 1.63767150832481e-10 mirMAP -0.105190928150912 0.00358458954728006 NA NA NA hsa-miR-29c-3p PPIC -1.4367517608807 1.61767774905781e-21 0.281500822429266 0.00428458804766994 MirTarget;miRNATAP -0.137838812629635 4.62934085264421e-06 23442884 RCC2 and PPIC were actually upregulated in gastric carcinoma tissues and therefore both were identified as possible targets of miR-29c in gastric carcinoma gastric cancer hsa-miR-21-5p PPIF 1.51084295924322 1.54551622173259e-34 -0.769387045826857 5.54110086115503e-11 miRNAWalker2_validate -0.367561626641704 2.21090335244967e-18 NA NA NA hsa-miR-194-5p PPIL6 -0.292530160992458 0.0996141384876663 -0.0465109908176669 0.794354378610582 mirMAP -0.156705955216275 0.00133237906523135 NA NA NA hsa-miR-181a-5p PPIP5K2 0.250113435902954 0.0551933249319293 -0.121113001332652 0.185235241842637 MirTarget;miRNATAP -0.150219232045387 9.44007462295652e-06 NA NA NA hsa-miR-181b-5p PPIP5K2 0.488256489401108 0.00105321129419701 -0.121113001332652 0.185235241842637 MirTarget;miRNATAP -0.122897280915088 3.17773373286669e-05 NA NA NA hsa-miR-30b-5p PPIP5K2 -0.54056186708617 2.44688760798341e-05 -0.121113001332652 0.185235241842637 MirTarget -0.133236526300184 0.000104696283991606 NA NA NA hsa-miR-15a-5p PPM1A 0.349521211668244 0.000770735998804736 -0.491863739444724 3.59260984655925e-09 MirTarget;miRNATAP -0.115578731408347 0.00369546544308881 NA NA NA hsa-miR-146b-5p PPM1B 0.419719546795449 0.0457375823220155 -0.275687173108442 0.000442253436356182 miRanda -0.105221645375473 4.19521559325583e-09 NA NA NA hsa-miR-181a-5p PPM1B 0.250113435902954 0.0551933249319293 -0.275687173108442 0.000442253436356182 mirMAP;miRNATAP -0.129226988201477 9.94632310168721e-06 NA NA NA hsa-miR-181b-5p PPM1B 0.488256489401108 0.00105321129419701 -0.275687173108442 0.000442253436356182 mirMAP;miRNATAP -0.114997723841133 6.11079243851445e-06 NA NA NA hsa-miR-27b-3p PPM1G -0.823491817819754 9.20935302746823e-14 0.574348560632392 2.1822247920007e-15 miRNATAP -0.163300387984826 2.75773895222118e-07 NA NA NA hsa-miR-146b-5p PPM1H 0.419719546795449 0.0457375823220155 -0.898968352231098 0.000570268284433191 miRanda;mirMAP -0.211221194990821 0.000497258571390223 NA NA NA hsa-miR-192-3p PPM1H -0.6401165114007 0.000266272092403814 -0.898968352231098 0.000570268284433191 mirMAP -0.201967398215826 0.00532162356062808 NA NA NA hsa-miR-192-3p PPM1J -0.6401165114007 0.000266272092403814 0.0175198468709874 0.933845244951608 MirTarget -0.255430993986428 9.85183423644853e-06 NA NA NA hsa-miR-146b-5p PPM1K 0.419719546795449 0.0457375823220155 -1.80173673515598 2.33082108102066e-18 MirTarget;miRanda -0.142979328614073 0.00414758298123656 NA NA NA hsa-miR-15a-5p PPM1K 0.349521211668244 0.000770735998804736 -1.80173673515598 2.33082108102066e-18 MirTarget -0.325657509455477 0.00129505047598408 NA NA NA hsa-miR-146b-5p PPM1L 0.419719546795449 0.0457375823220155 -0.358173274286561 0.0774099414261059 miRanda -0.116237471905946 0.0135091010610473 NA NA NA hsa-miR-15a-5p PPM1L 0.349521211668244 0.000770735998804736 -0.358173274286561 0.0774099414261059 MirTarget -0.200805781902911 0.0359373943267157 NA NA NA hsa-miR-181a-5p PPM1L 0.250113435902954 0.0551933249319293 -0.358173274286561 0.0774099414261059 mirMAP -0.381624945223448 4.01710544605393e-07 NA NA NA hsa-miR-181b-5p PPM1L 0.488256489401108 0.00105321129419701 -0.358173274286561 0.0774099414261059 mirMAP -0.324347698608955 7.48558798267414e-07 NA NA NA hsa-miR-20a-5p PPM1L 0.854326758727003 5.04256669663285e-07 -0.358173274286561 0.0774099414261059 mirMAP -0.311916768203704 3.74774994747641e-08 NA NA NA hsa-miR-21-5p PPM1L 1.51084295924322 1.54551622173259e-34 -0.358173274286561 0.0774099414261059 miRNAWalker2_validate -0.34957959654957 1.87441685478428e-06 NA NA NA hsa-miR-221-3p PPM1L 1.12244756358612 3.48370308238012e-13 -0.358173274286561 0.0774099414261059 mirMAP -0.347809048765759 1.51226412791389e-08 NA NA NA hsa-miR-222-3p PPM1L 1.08574156066353 1.76407192348131e-11 -0.358173274286561 0.0774099414261059 mirMAP -0.281168162026438 2.11954098809144e-06 NA NA NA hsa-miR-409-3p PPM1L -0.499649792570937 0.0526751181520117 -0.358173274286561 0.0774099414261059 mirMAP -0.107788383722297 0.00484562378296409 NA NA NA hsa-miR-455-5p PPP1CB -0.270546034117157 0.0581320703577731 -0.113089181371475 0.070517400699001 PITA;miRanda -0.108589825999147 2.28031215864973e-07 NA NA NA hsa-miR-27b-3p PPP1CC -0.823491817819754 9.20935302746823e-14 0.49737777455741 2.71927608312891e-12 miRNATAP -0.13676023941215 1.07893706554136e-05 NA NA NA hsa-miR-148a-3p PPP1R12A -0.748702855596996 3.93313343865641e-07 0.0309603223785082 0.720960796133803 MirTarget;miRNATAP -0.102194619282546 0.000270364516263776 NA NA NA hsa-miR-192-5p PPP1R12A -0.50188499512787 0.00344713341196035 0.0309603223785082 0.720960796133803 miRNAWalker2_validate -0.108797826979812 7.21116611846716e-06 NA NA NA hsa-miR-455-5p PPP1R12A -0.270546034117157 0.0581320703577731 0.0309603223785082 0.720960796133803 MirTarget;PITA;miRanda;miRNATAP -0.107263899740889 0.000264346477653572 NA NA NA hsa-miR-194-5p PPP1R12B -0.292530160992458 0.0996141384876663 -0.400775560101386 0.000211934336132358 mirMAP -0.111007259827951 0.000188360932468795 NA NA NA hsa-miR-19b-3p PPP1R12B 0.601279551368824 0.00016685097085251 -0.400775560101386 0.000211934336132358 mirMAP -0.101411822223436 0.0020921573418751 NA NA NA hsa-miR-505-5p PPP1R14B -0.768282569967001 1.14662846595407e-05 0.658960713330338 6.62140905744446e-07 miRNATAP -0.190496751706507 1.90679262891837e-07 NA NA NA hsa-miR-29c-3p PPP1R14C -1.4367517608807 1.61767774905781e-21 0.861992223126234 0.0105667533127022 miRNAWalker2_validate -0.409628447966099 7.60163786981373e-05 NA NA NA hsa-miR-30e-5p PPP1R14C -0.627815042856657 3.02205690184908e-10 0.861992223126234 0.0105667533127022 MirTarget -0.650919165246744 6.21959064199491e-05 NA NA NA hsa-miR-34a-5p PPP1R15B 1.03694231790865 5.74864019540594e-14 -0.473528343843502 1.32857809044433e-07 miRNATAP -0.102600033969134 0.000975493953678065 NA NA NA hsa-miR-132-3p PPP1R1C 0.323796239695997 0.00272093067935091 -2.22076468398843 1.88897890414879e-09 MirTarget -0.399262398678867 0.019746352767893 NA NA NA hsa-miR-20a-5p PPP1R3B 0.854326758727003 5.04256669663285e-07 -1.91981385054872 2.06614046154102e-21 MirTarget;miRNATAP -0.193609975216155 0.00128607596500601 NA NA NA hsa-miR-21-5p PPP1R3B 1.51084295924322 1.54551622173259e-34 -1.91981385054872 2.06614046154102e-21 MirTarget;miRNATAP -0.814270913907123 2.33116286083925e-29 NA NA NA hsa-miR-192-5p PPP1R3D -0.50188499512787 0.00344713341196035 -0.0770264679450831 0.62630578081029 MirTarget;miRNATAP -0.196047609762349 1.0181434476316e-05 NA NA NA hsa-miR-148a-3p PPP1R9A -0.748702855596996 3.93313343865641e-07 -0.189630957451167 0.529029203320251 MirTarget -0.382420008575662 9.31566121697617e-05 NA NA NA hsa-miR-505-5p PPP2R1A -0.768282569967001 1.14662846595407e-05 0.434617655824211 2.19736728815959e-07 miRNAWalker2_validate -0.101132276982143 1.32519884220096e-05 NA NA NA hsa-miR-15a-5p PPP2R1B 0.349521211668244 0.000770735998804736 -0.366373279268895 0.0120240053013953 MirTarget -0.149129894906409 0.0304654709530036 NA NA NA hsa-miR-30b-5p PPP2R1B -0.54056186708617 2.44688760798341e-05 -0.366373279268895 0.0120240053013953 miRNATAP -0.174282215186143 0.00161533222972509 NA NA NA hsa-miR-20a-5p PPP2R2A 0.854326758727003 5.04256669663285e-07 -0.893386744728836 1.42691109729952e-19 MirTarget;miRNATAP -0.124111638240801 1.90528354769801e-05 NA NA NA hsa-miR-192-5p PPP2R2C -0.50188499512787 0.00344713341196035 2.04406049288738 0.000156223168786157 mirMAP -0.907229698394586 2.29871744989232e-09 NA NA NA hsa-miR-194-5p PPP2R2C -0.292530160992458 0.0996141384876663 2.04406049288738 0.000156223168786157 miRNATAP -0.955546890731209 7.00101635982174e-11 NA NA NA hsa-miR-20a-5p PPP2R3A 0.854326758727003 5.04256669663285e-07 -0.234918525572345 0.207468150002507 mirMAP -0.126270382385945 0.0167740496803341 NA NA NA hsa-miR-34a-5p PPP2R3A 1.03694231790865 5.74864019540594e-14 -0.234918525572345 0.207468150002507 MirTarget;miRNATAP -0.266106623157513 2.83078545581018e-05 NA NA NA hsa-miR-192-5p PPP2R3B -0.50188499512787 0.00344713341196035 1.01219188204876 5.93858615542726e-19 miRNAWalker2_validate -0.108639411524065 0.0012321422143427 NA NA NA hsa-miR-215-5p PPP2R3B -0.981544773246509 3.14452272477156e-05 1.01219188204876 5.93858615542726e-19 miRNAWalker2_validate -0.128820590683626 8.21995950564856e-08 NA NA NA hsa-miR-132-3p PPP2R5C 0.323796239695997 0.00272093067935091 -0.197681049931807 0.00357159893729652 miRNATAP -0.13851439885365 5.20803505364117e-06 NA NA NA hsa-miR-146b-5p PPP2R5E 0.419719546795449 0.0457375823220155 -0.33926942209527 0.000598805950355048 miRanda -0.106437767995404 2.95231299168685e-06 NA NA NA hsa-miR-19b-3p PPP2R5E 0.601279551368824 0.00016685097085251 -0.33926942209527 0.000598805950355048 miRTarBase;MirTarget -0.105521131212065 0.000437479384635745 NA NA NA hsa-miR-455-5p PPP2R5E -0.270546034117157 0.0581320703577731 -0.33926942209527 0.000598805950355048 miRanda -0.122888449602669 0.000278155025334759 NA NA NA hsa-miR-17-3p PPP3CA 0.410352776142368 0.00422200500748636 -0.536165287387848 2.77787023947662e-11 MirTarget -0.148715997251777 6.8452735631761e-08 NA NA NA hsa-miR-20a-5p PPP3CA 0.854326758727003 5.04256669663285e-07 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.13596145796804 2.84983869383186e-09 NA NA NA hsa-miR-21-5p PPP3CA 1.51084295924322 1.54551622173259e-34 -0.536165287387848 2.77787023947662e-11 miRNATAP -0.143821297395015 1.2695170248385e-06 NA NA NA hsa-miR-181a-5p PPP3R1 0.250113435902954 0.0551933249319293 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.13691462952235 1.55708164198961e-08 NA NA NA hsa-miR-181b-5p PPP3R1 0.488256489401108 0.00105321129419701 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.13726473522507 5.36198845965272e-11 NA NA NA hsa-miR-29c-3p PPT1 -1.4367517608807 1.61767774905781e-21 0.240396189890022 0.0256384079899708 miRNAWalker2_validate -0.117810424512559 0.000358412504769618 NA NA NA hsa-miR-30b-5p PPTC7 -0.54056186708617 2.44688760798341e-05 -0.944376565774496 0.00024775259379255 MirTarget;mirMAP -0.270010952468585 0.00602499544852996 NA NA NA hsa-miR-146b-5p PQLC3 0.419719546795449 0.0457375823220155 -0.441550833103361 0.00124871420128405 miRanda -0.104451750565059 0.00100469635410672 NA NA NA hsa-miR-148a-3p PQLC3 -0.748702855596996 3.93313343865641e-07 -0.441550833103361 0.00124871420128405 MirTarget -0.227416925597569 2.92661541481649e-07 NA NA NA hsa-miR-181a-5p PRAP1 0.250113435902954 0.0551933249319293 -0.529522059151835 0.148965560219849 miRNAWalker2_validate;miRTarBase -0.686952718261687 4.599228315955e-07 NA NA NA hsa-miR-19b-3p PRDM1 0.601279551368824 0.00016685097085251 -0.369994804320361 0.0215976750638078 miRNATAP -0.130411934014131 0.00774442015307888 NA NA NA hsa-miR-20a-5p PRDM2 0.854326758727003 5.04256669663285e-07 -0.339899736847659 4.69085239503072e-05 miRNATAP -0.111009518622204 2.3953156098993e-06 NA NA NA hsa-miR-221-3p PRDM2 1.12244756358612 3.48370308238012e-13 -0.339899736847659 4.69085239503072e-05 miRNATAP -0.12549511481209 8.66247217462794e-07 NA NA NA hsa-miR-192-5p PRDM4 -0.50188499512787 0.00344713341196035 0.265885941113794 0.000114217472510259 miRNAWalker2_validate -0.10288977646582 9.70690120754843e-08 NA NA NA hsa-miR-146b-5p PRDM5 0.419719546795449 0.0457375823220155 -0.317067258225598 0.246070109990283 miRanda -0.160843762169445 0.0111385212598708 NA NA NA hsa-miR-192-3p PRDM5 -0.6401165114007 0.000266272092403814 -0.317067258225598 0.246070109990283 mirMAP -0.37421847122643 5.40446835222151e-07 NA NA NA hsa-miR-455-5p PRDM5 -0.270546034117157 0.0581320703577731 -0.317067258225598 0.246070109990283 miRanda -0.299624685136453 0.00133340670391606 NA NA NA hsa-miR-181a-5p PRDX3 0.250113435902954 0.0551933249319293 -0.775710711220344 3.34987294348607e-14 miRNAWalker2_validate;MirTarget -0.198462413756353 3.89405514938629e-07 NA NA NA hsa-miR-181b-5p PRDX3 0.488256489401108 0.00105321129419701 -0.775710711220344 3.34987294348607e-14 MirTarget -0.209590675235906 5.39948655363732e-10 NA NA NA hsa-miR-146b-5p PRELP 0.419719546795449 0.0457375823220155 -2.5558653032329 1.87476815966153e-13 mirMAP -0.182001235520772 0.0286653421585246 NA NA NA hsa-miR-192-3p PRELP -0.6401165114007 0.000266272092403814 -2.5558653032329 1.87476815966153e-13 mirMAP -0.442604566819637 6.57781464309321e-06 NA NA NA hsa-miR-20a-5p PRELP 0.854326758727003 5.04256669663285e-07 -2.5558653032329 1.87476815966153e-13 mirMAP -0.593531651610012 2.7477033723009e-09 NA NA NA hsa-miR-21-5p PREPL 1.51084295924322 1.54551622173259e-34 -0.0505743779794514 0.543479808946717 miRNAWalker2_validate -0.106206266700281 0.000417724264158222 NA NA NA hsa-miR-192-3p PREX1 -0.6401165114007 0.000266272092403814 0.191440345515606 0.183943559454544 mirMAP -0.197162394769547 5.31631245677043e-07 NA NA NA hsa-miR-194-5p PREX1 -0.292530160992458 0.0996141384876663 0.191440345515606 0.183943559454544 mirMAP -0.187321314215743 1.71469733687671e-06 NA NA NA hsa-miR-192-5p PRICKLE1 -0.50188499512787 0.00344713341196035 -1.74028095832004 2.56191738876965e-10 miRNAWalker2_validate -0.647920508976856 3.38291204645263e-17 NA NA NA hsa-miR-148a-3p PRICKLE2 -0.748702855596996 3.93313343865641e-07 -1.36375835552812 1.67599789165395e-08 MirTarget;miRNATAP -0.361824889511995 5.66694348602003e-06 NA NA NA hsa-miR-194-5p PRICKLE2 -0.292530160992458 0.0996141384876663 -1.36375835552812 1.67599789165395e-08 miRNATAP -0.255884515251328 0.000142668537041326 NA NA NA hsa-miR-21-5p PRICKLE2 1.51084295924322 1.54551622173259e-34 -1.36375835552812 1.67599789165395e-08 miRNAWalker2_validate;MirTarget -0.234850115033432 0.00889222361721155 NA NA NA hsa-miR-224-3p PRICKLE2 1.40770116795301 1.31426607144612e-08 -1.36375835552812 1.67599789165395e-08 mirMAP -0.194235568747061 5.0034200553647e-05 NA NA NA hsa-miR-15a-5p PRIMA1 0.349521211668244 0.000770735998804736 -3.76976020132228 1.35726706752041e-26 mirMAP -0.434541099722777 0.0145126816515879 NA NA NA hsa-miR-15a-5p PRKAA1 0.349521211668244 0.000770735998804736 -0.60864021207068 5.26267892833978e-12 MirTarget -0.127934215917556 0.00259652352236475 NA NA NA hsa-miR-30e-5p PRKAA2 -0.627815042856657 3.02205690184908e-10 0.910177606708893 0.0133266185680845 MirTarget -0.438345582649116 0.0139749918956882 NA NA NA hsa-miR-21-5p PRKAB2 1.51084295924322 1.54551622173259e-34 0.56659891692032 3.41527340619955e-05 miRNAWalker2_validate -0.138674962156893 0.00579019389615852 NA NA NA hsa-miR-29c-3p PRKAB2 -1.4367517608807 1.61767774905781e-21 0.56659891692032 3.41527340619955e-05 miRNAWalker2_validate;miRNATAP -0.112103704802727 0.0081989397988645 NA NA NA hsa-miR-19b-3p PRKACB 0.601279551368824 0.00016685097085251 -0.439902334736784 5.50105175875769e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.115986971473871 0.00048141723506022 NA NA NA hsa-miR-181a-5p PRKAG2 0.250113435902954 0.0551933249319293 -1.10180393486939 5.09146502361984e-14 miRNATAP -0.407255036398201 1.42238960893816e-13 NA NA NA hsa-miR-181b-5p PRKAG2 0.488256489401108 0.00105321129419701 -1.10180393486939 5.09146502361984e-14 miRNATAP -0.425871154369953 1.72572702795849e-19 NA NA NA hsa-miR-20a-5p PRKAR2A 0.854326758727003 5.04256669663285e-07 -0.445956894636509 0.039701655854281 mirMAP -0.144423440498608 0.0189487099139109 NA NA NA hsa-miR-21-5p PRKAR2A 1.51084295924322 1.54551622173259e-34 -0.445956894636509 0.039701655854281 mirMAP -0.324627317167112 3.73345274692546e-05 NA NA NA hsa-miR-146a-5p PRKCA -0.742958238440575 0.000765983177482633 0.662827897377551 1.5305893364122e-08 mirMAP -0.137245496572864 1.03630471721186e-07 NA NA NA hsa-miR-181a-5p PRKCA 0.250113435902954 0.0551933249319293 0.662827897377551 1.5305893364122e-08 mirMAP -0.254408568412877 7.16377375327665e-09 NA NA NA hsa-miR-181b-5p PRKCA 0.488256489401108 0.00105321129419701 0.662827897377551 1.5305893364122e-08 mirMAP -0.205095445188407 8.90870928470555e-08 NA NA NA hsa-miR-194-5p PRKCB -0.292530160992458 0.0996141384876663 -1.62067363753233 3.76201992658756e-13 miRNATAP -0.310861421038956 6.51903986219064e-07 NA NA NA hsa-miR-27b-3p PRKCD -0.823491817819754 9.20935302746823e-14 0.661163999475378 2.10919242029348e-07 miRNATAP -0.145306305033983 0.00898991443202175 NA NA NA hsa-miR-19b-3p PRKCE 0.601279551368824 0.00016685097085251 -0.525415812633483 0.00121438245155814 mirMAP -0.127907312060718 0.0098350417787119 NA NA NA hsa-miR-21-5p PRKCE 1.51084295924322 1.54551622173259e-34 -0.525415812633483 0.00121438245155814 miRNAWalker2_validate -0.368254580492906 2.77693046693172e-10 NA NA NA hsa-miR-34a-5p PRKCQ 1.03694231790865 5.74864019540594e-14 -0.802928469295256 0.000820998583679759 MirTarget -0.304675459218439 0.000223564844609025 NA NA NA hsa-miR-455-5p PRKCQ -0.270546034117157 0.0581320703577731 -0.802928469295256 0.000820998583679759 miRanda -0.224679365448967 0.0065259288783781 NA NA NA hsa-miR-15a-5p PRKG1 0.349521211668244 0.000770735998804736 -1.38853534989461 1.21422425786253e-07 miRNATAP -0.50665424001085 4.94126330305548e-05 NA NA NA hsa-miR-192-5p PRKG1 -0.50188499512787 0.00344713341196035 -1.38853534989461 1.21422425786253e-07 miRNATAP -0.363364288156679 1.18927836843635e-06 NA NA NA hsa-miR-21-5p PRKG1 1.51084295924322 1.54551622173259e-34 -1.38853534989461 1.21422425786253e-07 mirMAP -0.4069850497267 2.52993522002991e-05 NA NA NA hsa-miR-34a-5p PRKG1 1.03694231790865 5.74864019540594e-14 -1.38853534989461 1.21422425786253e-07 miRNATAP -0.360831587364883 7.41963200238258e-05 NA NA NA hsa-miR-148a-3p PRKX -0.748702855596996 3.93313343865641e-07 -0.240211607134995 0.240371070351319 MirTarget -0.590431480469924 2.08013051455884e-20 NA NA NA hsa-miR-455-3p PRKY -1.3998033821095 5.72010709806871e-17 1.04027139986286 0.0271317427328725 PITA -0.390927088204572 0.00311694008719063 NA NA NA hsa-miR-148a-3p PRNP -0.748702855596996 3.93313343865641e-07 -1.31457732397415 1.33903555838973e-11 miRNAWalker2_validate;MirTarget -0.397460387082465 5.03565447558832e-10 NA NA NA hsa-miR-192-5p PRNP -0.50188499512787 0.00344713341196035 -1.31457732397415 1.33903555838973e-11 miRNAWalker2_validate -0.341623379550827 7.41265782181979e-10 NA NA NA hsa-miR-455-5p PRNP -0.270546034117157 0.0581320703577731 -1.31457732397415 1.33903555838973e-11 miRanda -0.260352165498727 0.000127292849182052 NA NA NA hsa-miR-34a-5p PROM2 1.03694231790865 5.74864019540594e-14 -2.4961418282484 3.43202959675422e-12 mirMAP -0.584133943629434 3.28817876199879e-06 NA NA NA hsa-miR-132-3p PROSC 0.323796239695997 0.00272093067935091 -1.22355924251928 9.36227369097222e-25 miRNAWalker2_validate -0.308373669138088 4.83121536904231e-08 NA NA NA hsa-miR-15a-5p PROSC 0.349521211668244 0.000770735998804736 -1.22355924251928 9.36227369097222e-25 MirTarget -0.148057031440357 0.0128847323049957 NA NA NA hsa-miR-181a-5p PROSC 0.250113435902954 0.0551933249319293 -1.22355924251928 9.36227369097222e-25 miRNAWalker2_validate -0.212128004817004 6.45976387147507e-06 NA NA NA hsa-miR-34a-5p PROSC 1.03694231790865 5.74864019540594e-14 -1.22355924251928 9.36227369097222e-25 miRNAWalker2_validate -0.126298208592395 0.00357170366603007 NA NA NA hsa-miR-181a-5p PROX1 0.250113435902954 0.0551933249319293 -1.50692887128896 6.55353144337011e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.288121737020304 0.00675093067025243 25706394 In addition the ectopic expression of miR-181a in the gastric cancer cell line HGC-27 inhibited cell proliferation cell migration and invasion by directly interacting with the mRNA encoding the oncogenic factor Prox1 cell migration gastric cancer hsa-miR-181b-5p PROX1 0.488256489401108 0.00105321129419701 -1.50692887128896 6.55353144337011e-08 MirTarget;miRNATAP -0.246977112719661 0.00760607606347608 NA NA NA hsa-miR-20a-5p PROX1 0.854326758727003 5.04256669663285e-07 -1.50692887128896 6.55353144337011e-08 mirMAP -0.208543678262212 0.00942086750821076 NA NA NA hsa-miR-34a-5p PROX1 1.03694231790865 5.74864019540594e-14 -1.50692887128896 6.55353144337011e-08 miRNATAP -0.250792393885838 0.0100173161255836 NA NA NA hsa-miR-148a-3p PRR15 -0.748702855596996 3.93313343865641e-07 0.490966715538301 0.252618237144631 MirTarget -0.37711038705465 0.00714647584683602 NA NA NA hsa-miR-20a-5p PRR15 0.854326758727003 5.04256669663285e-07 0.490966715538301 0.252618237144631 MirTarget;miRNATAP -0.385613761194822 0.00148467680487152 NA NA NA hsa-miR-15a-5p PRR15L 0.349521211668244 0.000770735998804736 -0.243529763709024 0.552754963950431 MirTarget -0.58882150257063 0.00226559726146995 NA NA NA hsa-miR-27b-3p PRR16 -0.823491817819754 9.20935302746823e-14 0.998430301852498 2.32891081406947e-06 MirTarget -0.298346958357085 0.00117921722863416 NA NA NA hsa-miR-20b-5p PRR18 0.457668023910379 0.0285865211936156 -2.20511773295967 6.27626901339299e-15 mirMAP -0.218923320946892 0.00129254178316132 NA NA NA hsa-miR-192-3p PRR5L -0.6401165114007 0.000266272092403814 0.340313427554474 0.141376755649448 mirMAP -0.319075223812573 4.48510868671218e-07 NA NA NA hsa-miR-19b-3p PRR5L 0.601279551368824 0.00016685097085251 0.340313427554474 0.141376755649448 MirTarget;miRNATAP -0.428683316927391 5.13793608592791e-10 NA NA NA hsa-miR-194-5p PRR7 -0.292530160992458 0.0996141384876663 1.31247403829517 1.68475957995442e-09 miRNATAP -0.257609060696464 2.16308657584962e-05 NA NA NA hsa-miR-455-3p PRR7 -1.3998033821095 5.72010709806871e-17 1.31247403829517 1.68475957995442e-09 PITA;miRNATAP -0.165016148277563 0.0081447867509344 NA NA NA hsa-miR-181a-5p PRRG1 0.250113435902954 0.0551933249319293 -0.908192707084856 3.41333706973093e-12 mirMAP -0.210740766280328 2.44112594437153e-05 NA NA NA hsa-miR-181b-5p PRRG1 0.488256489401108 0.00105321129419701 -0.908192707084856 3.41333706973093e-12 mirMAP -0.222221738806921 2.7162951837363e-07 NA NA NA hsa-miR-20a-5p PRRG1 0.854326758727003 5.04256669663285e-07 -0.908192707084856 3.41333706973093e-12 MirTarget;miRNATAP -0.379972582979808 1.55743256143634e-26 NA NA NA hsa-miR-21-5p PRRG1 1.51084295924322 1.54551622173259e-34 -0.908192707084856 3.41333706973093e-12 MirTarget -0.29970624846694 4.07127207882099e-10 NA NA NA hsa-miR-146b-5p PRRT1 0.419719546795449 0.0457375823220155 -0.0893136891352508 0.593477169466613 miRanda -0.103376396300234 0.00757853766115637 NA NA NA hsa-miR-455-5p PRRX1 -0.270546034117157 0.0581320703577731 2.13747637731194 2.98162416691034e-16 miRanda -0.500366368942583 4.97619348289253e-08 NA NA NA hsa-miR-192-5p PRSS23 -0.50188499512787 0.00344713341196035 -0.308894863963872 0.0807584384856214 miRNAWalker2_validate -0.405857208642736 4.31384004876541e-17 NA NA NA hsa-miR-27b-3p PRX -0.823491817819754 9.20935302746823e-14 0.973700085344309 4.95602829998367e-13 miRNATAP -0.123045728858212 0.0396745642493614 NA NA NA hsa-miR-29c-3p PRX -1.4367517608807 1.61767774905781e-21 0.973700085344309 4.95602829998367e-13 mirMAP -0.228611741134947 5.58462336526964e-08 NA NA NA hsa-miR-505-5p PSAPL1 -0.768282569967001 1.14662846595407e-05 0.482594104957242 0.150716803966048 mirMAP -0.264945594393739 0.00423958755032822 NA NA NA hsa-miR-455-5p PSCA -0.270546034117157 0.0581320703577731 1.41644384506328 3.35588801143345e-06 miRanda -0.224856642131928 0.033474082872741 NA NA NA hsa-miR-17-3p PSD3 0.410352776142368 0.00422200500748636 -1.20252145080477 1.19868322011977e-09 mirMAP -0.170315852116293 0.0130973930956879 NA NA NA hsa-miR-181a-5p PSD3 0.250113435902954 0.0551933249319293 -1.20252145080477 1.19868322011977e-09 mirMAP -0.481364662661391 8.64884218593896e-11 NA NA NA hsa-miR-181b-5p PSD3 0.488256489401108 0.00105321129419701 -1.20252145080477 1.19868322011977e-09 mirMAP -0.461162772149117 6.63323598690523e-13 NA NA NA hsa-miR-20a-5p PSD3 0.854326758727003 5.04256669663285e-07 -1.20252145080477 1.19868322011977e-09 miRNAWalker2_validate -0.222849941727187 8.97636973532176e-05 NA NA NA hsa-miR-432-5p PSD3 -0.536178819038888 0.0748623258271085 -1.20252145080477 1.19868322011977e-09 mirMAP -0.116737260577426 0.000348292760704021 NA NA NA hsa-miR-30c-5p PSEN2 -0.432111642767632 0.000159764714931007 0.387153271232775 0.000693917785616684 miRNATAP -0.188330531569865 0.000105139735356388 NA NA NA hsa-miR-27b-3p PSMA1 -0.823491817819754 9.20935302746823e-14 0.237565655931445 4.93421992716562e-05 MirTarget -0.118656229357411 1.96143450937939e-06 NA NA NA hsa-miR-132-3p PSMA2 0.323796239695997 0.00272093067935091 -0.390800012363166 9.5449730317426e-07 miRNAWalker2_validate -0.130236368313688 0.000335900356604921 NA NA NA hsa-miR-181a-5p PSMA5 0.250113435902954 0.0551933249319293 -0.000190781838072418 0.998363086048208 mirMAP -0.161339607677061 2.76133111163557e-06 NA NA NA hsa-miR-181b-5p PSMA5 0.488256489401108 0.00105321129419701 -0.000190781838072418 0.998363086048208 mirMAP -0.144187844601641 1.4371657957329e-06 NA NA NA hsa-miR-30e-5p PSMA6 -0.627815042856657 3.02205690184908e-10 0.282750442366154 0.000263359154455377 miRNAWalker2_validate -0.10520933039004 0.00499347440803937 NA NA NA hsa-miR-30e-5p PSMB5 -0.627815042856657 3.02205690184908e-10 0.368600506141934 3.77259715179137e-07 miRNAWalker2_validate -0.189124333669544 5.85515425013481e-08 NA NA NA hsa-miR-192-5p PSMC3IP -0.50188499512787 0.00344713341196035 2.9342125654124 3.69090301103456e-32 miRNAWalker2_validate -0.2704228562381 0.000377197692451599 NA NA NA hsa-miR-215-5p PSMC3IP -0.981544773246509 3.14452272477156e-05 2.9342125654124 3.69090301103456e-32 miRNAWalker2_validate -0.191366097340252 0.0004977807123114 NA NA NA hsa-miR-192-5p PSRC1 -0.50188499512787 0.00344713341196035 1.87705568740869 1.48800397430135e-21 miRNAWalker2_validate -0.11621911267529 0.0483972413932611 NA NA NA hsa-miR-215-5p PSRC1 -0.981544773246509 3.14452272477156e-05 1.87705568740869 1.48800397430135e-21 miRNAWalker2_validate -0.153403598235942 0.000287087275912449 NA NA NA hsa-miR-30c-5p PSTPIP2 -0.432111642767632 0.000159764714931007 -0.0422756004845075 0.808247688808499 miRNATAP -0.148147919739374 0.0459102105749017 NA NA NA hsa-miR-21-5p PTAR1 1.51084295924322 1.54551622173259e-34 -0.30295618795535 0.00286391397269786 miRNAWalker2_validate;mirMAP -0.257873578273132 9.8848770375557e-13 NA NA NA hsa-miR-192-5p PTBP2 -0.50188499512787 0.00344713341196035 0.469748381960924 7.20177143528794e-06 miRNAWalker2_validate -0.118453910975341 6.86134286027003e-05 NA NA NA hsa-miR-146b-5p PTCH1 0.419719546795449 0.0457375823220155 -0.77814763515361 7.5867355509332e-05 miRanda -0.16038004140192 0.00046159966201589 NA NA NA hsa-miR-15a-5p PTCH1 0.349521211668244 0.000770735998804736 -0.77814763515361 7.5867355509332e-05 miRNATAP -0.286578570246224 0.00211093001191547 NA NA NA hsa-miR-21-5p PTCH1 1.51084295924322 1.54551622173259e-34 -0.77814763515361 7.5867355509332e-05 mirMAP -0.229498420855219 0.00147432260745022 NA NA NA hsa-miR-132-3p PTEN 0.323796239695997 0.00272093067935091 -0.546254680094508 2.77576587245444e-08 miRNATAP -0.25299424939486 1.34753285647319e-08 NA NA NA hsa-miR-181b-5p PTEN 0.488256489401108 0.00105321129419701 -0.546254680094508 2.77576587245444e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.114085044640472 0.000438213061284522 NA NA NA hsa-miR-21-5p PTEN 1.51084295924322 1.54551622173259e-34 -0.546254680094508 2.77576587245444e-08 miRNAWalker2_validate;miRTarBase;mirMAP -0.235206406510716 3.9272579156044e-11 23684551;17681183;25973032;26311740;26387181;22267008;26384051;22322462;27644439;21471222;21468550;20113523;26905520;21806946;24154840;27611950;24780321;25027758;23036707;26559642;26731559;26847601;27350731;24331411;21820606;25909227;24930006;24293118;26289851;22547075;26666820;24324076;23201752;25963606;27188433;22958183;22956424;19730150;21842656;21104017;23894315;23548551;26236156;23951172;24460329;20092645;25563770;24659669;25647415;26230405;25543482;20048743;27725205;23466500;22922228;25058005;20223231;27220494;22678116;24763002;24221338;22120473;21408027;23174819;22832383;19212625;22978663;25799148;26741162;23226804;26787105;26864640;25603978;26975392 MicroRNA 21 suppresses PTEN and hSulf 1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways;MicroRNA 21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer; PTEN was shown to be a direct target of miR-21 and to contribute to miR-21 effects on cell invasion; Modulation of miR-21 altered focal adhesion kinase phosphorylation and expression of matrix metalloproteases 2 and 9 both downstream mediators of PTEN involved in cell migration and invasion; Aberrant expression of miR-21 can contribute to HCC growth and spread by modulating PTEN expression and PTEN-dependent pathways involved in mediating phenotypic characteristics of cancer cells such as cell growth migration and invasion;PDCD4 and PTEN expression was decreased gradually after tumor induction and negatively correlated with miR-21 expression; Our in vivo experiments further confirmed that miR-21 plays an important role in promoting the occurrence and development of HCC by regulating PDCD4 and PTEN;Exposure of HCC cells to sorafenib led to an increase in miR-21 expression a decrease in PTEN expression and sequential Akt activation;In addition treated with 5-AZA resulted in significant increases of miR-21 expression in both MCF-7 and MDA-MB-231 cells P < 0.01 with the protein level of PTEN increased in MCF-7 cell which was further involved in the downregulation of AKT;microRNA 21 promotes tumor proliferation and invasion in gastric cancer by targeting PTEN; Thus in this study we focused on the expression and significance of miR-21 in gastric cancer tissues and the role of miR-21 in the biological behaviour and the expression of PTEN in gastric cancer cells; Western blotting and the Luciferase Reporter Assay were used to evaluate the change of PTEN expression after lowered expression of miR-21 in gastric cancer cell lines; The western blot results and Luciferase Reporter Assay demonstrated that PTEN expression was remarkably increased after miR-21 inhibition P<0.05 microRNA-21 expression was upregulated in gastric carcinoma tissues and was significantly associated with the degree of differentiation of tumour tissues local invasion and lymph node metastasis;Furthermore we identified that miR-21 overexpression could promote Hela and U2OS cells proliferation by targeting phosphatase-tensin homolog PTEN the result of which can be rescued by miR-21 inhibitor;Inhibition of microRNA-21 mir‑21 induced upregulation of Spry2 and PTEN which underscores the importance of mir-21 in Spry2-associated tumorigenesis of the colon;Bmi-1 also regulates p53 and PTEN via miR-21;Here we demonstrated that miR-21 expression was up-regulated and its function was elevated in HER2+ BT474 SKBR3 and MDA-MB-453 breast cancer cells that are induced to acquire trastuzumab resistance by long-term exposure to the antibody whereas protein expression of the PTEN gene a miR-21 target was reduced; Rescuing PTEN expression with a p3XFLAG-PTEN-mut construct with deleted miR-21 targeting sequence at its 3' UTR restored the growth inhibition of trastuzumab in the resistant cells by inducing PTEN activation and AKT inhibition; In vivo administering miR-21 antisense oligonucleotides restored trastuzumab sensitivity in the resistant breast cancer xenografts by inducing PTEN expression whereas injection of miR-21 mimics conferred trastuzumab resistant in the sensitive breast tumors via PTEN silence;The expression of miR-21 and its target PTEN was determined by real-time qRT-PCR and western blotting respectively in tumor tissues as well as adjacent non-tumor mucosa; miR-21 was significantly up-regulated in tumor tissues while PTEN was expressed in lower levels compared to non-tumor tissues; A negative correlation between expression of miR-21 and PTEN was established in vivo;MicroRNA 21 inhibitor sensitizes human glioblastoma cells U251 PTEN mutant and LN229 PTEN wild type to taxol; Human glioblastoma U251 PTEN-mutant and LN229 PTEN wild-type cells were treated with taxol and the miR-21 inhibitor in a poly amidoamine PAMAM dendrimer alone or in combination; Interestingly the above data suggested that in both the PTEN mutant and the wild-type GBM cells miR-21 blockage increased the chemosensitivity to taxol; Thus the miR-21 inhibitor might interrupt the activity of EGFR pathways independently of PTEN status;The effect of ZA on miR-21 expression was quantified by qRT-PCR and the amount of PTEN protein and its targets were analyzed by Western blot;NTR1 activation stimulates expression of miR-21 and miR-155 in colonocytes via Akt and NF-κB to down-regulate PTEN and SOCS1 and promote growth of tumors in mice;Correlations between the expression levels of miR-21 PTEN and p-AKT were analyzed by real-time PCR and Western blot test in HER2-positive GC cell lines; Overexpression of miR-21 down-regulated PTEN expression increased AKT phosphorylation and did not affect HER2 expression; Inversely suppression of miR-21 increased PTEN expression and down-regulated AKT phosphorylation but still did not affect HER2 expression;MicroRNA 21 promotes TGF β1 induced epithelial mesenchymal transition in gastric cancer through up regulating PTEN expression; In GC tissues the expressions of miR-21 Akt and p-Akt were up-regulated while PTEN expression was down-regulated; These results suggest that miR-21 could promote TGF-β1-induced EMT in GC cells through up-regulating PTEN expression;Expressions of PTEN were significantly down-regulated in CRC tissues and negatively correlated with expressions of Notch-1 r2=0.5207 p<0.01 and miR-21 r2=0.6996 p<0.01; These data indicate that the crosstalk between Notch-1 and miR-21 is involved in CRC development through degradation of PTEN;In the same patients we also compared miR-21 expression with the expression of its presumed target PTEN; miR-21 expression levels were found to significantly correlate with tumour size r = 0.403 p = 0.009; Spearman's rank whereas no relation was found between miR-21 and PTEN expression levels Kruskal-Wallis test;Over-expression of miR-21 suppressed its target PTEN and disrupted acinar morphogenesis;There was overexpression of the miR-21 target genes PTEN by 67% and caspase-3 by 15% upon cotreatment;We previously reported that microRNA-21 miR-21 was strongly expressed in melanoma relative to naevi and now sought to further assess the significance of this by assessing its relationship with its putative target PTEN; Clinical melanoma samples were analysed by immunohistochemical analysis for PTEN stem-loop qRT-PCR for miR-21 and PCR for BRAF/NRAS mutation status; miR-21 expression was inversely associated with nuclear PTEN expression but not with cytoplasmic PTEN expression; These data suggest miR-21 may exert an oncogenic effect in melanoma by favouring redistribution of PTEN to the nucleus;Triptolide reduces proliferation and enhances apoptosis of human non small cell lung cancer cells through PTEN by targeting miR 21; To the best of our knowledge the present study is the first to demonstrate that triptolide reduced the proliferation and enhanced the apoptosis of human NSCLC cells through PTEN by targeting miR-21;Quantitative real-time PCR qRT-PCR and Western blot were used to detect the expression levels of miR-21 and PTEN in HCT116 HT29 Colo32 and SW480 CRC cell lines; Also the expression levels of PTEN mRNA and its downstream proteins AKT and PI3K in HCT116 cells after downregulating miR-21 were investigated; In comparing the levels of PTEN protein and downstream AKT and PI3K in HCT116 cells after downregulation of miR-21 expression the levels of AKT and PI3K protein expression significantly decreased P < 0.05; PTEN is one of the direct target genes of miR-21;The level of miR-21 was reversely correlated with the expression of PTEN and PDCD4 and positive correlated with PI3K/Akt pathway; miR-21 is involved in acquired resistance of EGFR-TKI in NSCLC which is mediated by down-regulating PTEN and PDCD4 and activating PI3K/Akt pathway;MicroRNA 21 modulates chemosensitivity of breast cancer cells to doxorubicin by targeting PTEN; TaqMan RT-PCR or Western blot assay was performed to detect the expression of mature miR-21 and tumor suppressor gene PTEN protein; We showed that upregulation of miR-21 in MCF-7/ADR cells was concurrent with downregulation of PTEN protein; Overexpression of PTEN could mimic the same effects of miR-21 inhibitor in MCF-7/ADR cells and PTEN-siRNA could increase the resistance of MCF-7 cells to ADR; MiR-21 inhibitor could increase PTEN protein expression and the luciferase activity of a PTEN 3' untranslated region-based reporter construct in MCF-7/ADR cells; Dysregulation of miR-21 plays critical roles in the ADR resistance of breast cancer at least in part via targeting PTEN;MiR-21 level was inversely correlated with the levels of FOXO1 and PTEN in DLBCL cell lines; MiR-21 also down-regulated PTEN expression and consequently activated the PI3K/AKT/mTOR pathway which further decreased FOXO1 expression;In present study we determined the miR-21 levels in TNBC specimens and TNBC cell levels in vitro and then identified the role of miR-21 on tumor cell proliferation apoptosis and then identified PTEN as the possible target of the microRNA;MiR 21 suppresses the anticancer activities of curcumin by targeting PTEN gene in human non small cell lung cancer A549 cells; Transfection of A549 cells with microRNA-21 mimic or PTEN small interfering RNA was performed to modulate the expression of microRNA-21 and PTEN under the treatment of curcumin; Moreover the protein level of PTEN a putative target of microRNA-21 was significantly elevated in curcumin-treated A549 cells as determined by Western blot analysis; Transfection of A549 cells with microRNA-21 mimic or PTEN small interfering RNA significantly P < 0.05 reversed the growth suppression and apoptosis induction by curcumin compared to corresponding controls; Our data suggest a novel molecular mechanism in which inhibition of microRNA-21 and upregulation of PTEN mediate the anticancer activities of curcumin in NSCLC cells;PTEN gene expression was performed as a known target of miR-21;Induction of miR-21 may enable cancer cells to elude DNA damage-induced apoptosis and enhance the metastatic potential of breast cancer cells through repressing expression of PTEN and PDCD4;PTEN a direct target gene of miR-21 was significantly downregulated in gemcitabine-resistant breast cancer cells and restoration of PTEN expression blocked miR-21-induced EMT and gemcitabine resistance;We also found that Rawq01 up-regulated the expression of PTEN through mir-21 inhibition and therefore inhibited the PI3K-AKT pathway;Moreover we demonstrate that oligonucleotide-mediated miR-21 silencing in U87 human GBM cells resulted in increased levels of the tumor suppressors PTEN and PDCD4 caspase 3/7 activation and decreased tumor cell proliferation;Overexpression of miR 21 promotes the proliferation and migration of cervical cancer cells via the inhibition of PTEN; The aim of this study was to examine the expression of miR-21 and PTEN in cervical cancer specimens using quantitative PCR; miR-21 was upregulated in the cervical cancer specimens negatively correlating with the PTEN mRNA level; Transfection of the miR-21 mimics was markedly promoted whereas the miR-21 inhibitor suppressed the proliferation migration and invasion of cervical cancer cells with a significant inhibition of PTEN expression; The present study showed the upregulation of miR-21 in invasive cervical cancers and confirmed the promotion of miR-21 with regard to the proliferation migration and invasion in cervical cancer cells via inhibiting the PTEN expression;The expressions of miR-21 PTEN PI3K and AKT were detected in 89 esophageal cancer samples and 58 adjacent normal tissues respectively; MiR-21 PI3K and AKT have higher expressions but PTEN has lower expression in esophageal cancer tissues compared with adjacent normal tissues; Further PTEN was a target gene of miR-21;The expression level of miR-21 and PTEN messenger RNA were measured by quantitative real-time reverse transcription polymerase chain reaction or reverse transcription polymerase chain reaction; miR-21 was overexpressed and PTEN was suppressed in established radioresistant TE-R60 cells compared with the parent cells 1.3-fold and 70.83%; The inhibition of miR-21 significantly increased the cells' radiosensitivity P < 0.05 and the PTEN protein expression 2.3-fold in TE-1 cells; Knockdown of PTEN in anti-miR-21 TE-1 cells could abrogate the miR-21 inhibition-induced radiosensitization P < 0.05; Inhibition of miR-21 increased radiosensitivity of esophageal cancer TE-1 cells and this effect was possibly through the activation of PTEN;MicroRNA 21 miR 21 expression promotes growth metastasis and chemo or radioresistance in non small cell lung cancer cells by targeting PTEN; Taken together these results provide evidence to show the promotion role of miR-21 in NSCLC development through modulation of the PTEN signaling pathway;Protein levels of tumor suppressor targets of the miRNAs were increased by antisense to miR-21 PTEN and RECK and miR-221 p27;The expression of miR-21 PTEN and PDCD4 were determined by Real-time PCR; Glossy ganoderma spore oil down-regulated the expression of miR-21 and up-regulated the expression of PTEN and PDCD4 significantly;Role of microRNA 21 and effect on PTEN in Kazakh's esophageal squamous cell carcinoma; To evaluate the role of miR-21 and PTEN cell proliferations were analyzed with miR-21 mimics or their inhibitor-transfected cells; In Eca109 when transfected with miR-21 mimics accumulation of miR-21 was obviously increased and expression of PTEN protein was decreased to be approximately 40% which resulted in the promotion of cell proliferation; However when transfected with miR-21 inhibitor expression of miR-21 was declined and PTEN protein was overexpressed to be approximately 79% which resulted in the suppression of cell proliferation; Furthermore there was a significantly inverse correlation between miR-21 expression and PTEN protein levels p < 0.05; The author concluded that MiR-21 was overexpressed in vitro and ESCC and promoted the cell proliferation might target PTEN at post-transcriptional level and regulated the cancer invasion in Kazakh's ESCC;Difluorinated curcumin CDF restores PTEN expression in colon cancer cells by down regulating miR 21; Indeed our current data demonstrate a marked downregulation of PTEN in SCID mice xenografts of miR-21 over-expressing colon cancer HCT116 cells; Colonospheres that are highly enriched in cancer stem/stem like cells reveal increased miR-21 expression and decreased PTEN; Difluorinated curcumin CDF a novel analog of the dietary ingredient curcumin which has been shown to inhibit the growth of 5-Flurouracil + Oxaliplatin resistant colon cancer cells downregulated miR-21 in chemo-resistant colon cancer HCT116 and HT-29 cells and restored PTEN levels with subsequent reduction in Akt phosphorylation;Moreover knockdown of miR-21 increased PDCD4 and PTEN expression at the protein level but not at the mRNA level;Mechanistic evidence showed that down-regulation of miR-21 increased the expression of its target molecule PTEN in HCT116 cells;The results showed that knockdown of miR-21 by antagomir-21 decreased cell proliferation and induced apoptosis via targeting PTEN both in 4T1 cells and HUVECs;Finally invasion and metastasis assays were performed and alteration in mir-21 PTEN AKT and pAKT level was evaluated in these cells; Enhanced invasion and metastasis increased miR-21 expression decreased PTEN elevated pAKT level were demonstrated in gemcitabine-resistant HPAC and PANC-1 cells;In the present study we investigated the role of miR-21 and its potential as a therapeutic target in two prostate cancer cell lines characterized by different miR-21 expression levels and PTEN gene status;Expressions of microRNA-21 miR-21 PTEN MMP9 and p47 were detected by qPCR;The protein levels of miR-21 targets PTEN and PDCD4 were estimated; In the control experiment miR-21 mimic significantly inhibited the expression of PTEN and PDCD4 proteins in the two gastric cell lines leading to an increase in cell invasion and migration; miR-21 is overexpressed in gastric cancer and its aberrant expression may have important role in gastric cancer growth and dissemination by modulating the expression of the tumor suppressors PTEN and PDCD4 as well as by modulating the pathways involved in mediating cell growth migration invasion and apoptosis;MiR-21 upregulation contributes to PTEN downregulation which is beneficial for the activation of PI3K/AKT signaling;microRNA 21 Regulates Cell Proliferation and Migration and Cross Talk with PTEN and p53 in Bladder Cancer; MicroRNA-21 regulates proliferation and migration of bladder cancer cells and cross talk with PTEN and p53 in bladder cancer;Moreover knockdown of miR-21 increased the expressions of PDCD4 and PTEN at the protein level but not at the mRNA level;Downregulation of miR 21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status; To explore whether miR-21 can serve as a therapeutic target for glioblastoma we downregulated miR-21 with a specific antisense oligonucleotide and found that apoptosis was induced and cell-cycle progression was inhibited in vitro in U251 PTEN mutant and LN229 PTEN wild-type GBM cells; xenograft tumors from antisense-treated U251 cells were suppressed in vivo; Taken together our studies provide evidence that miR-21 may serve as a novel therapeutic target for malignant gliomas independent of PTEN status;The results showed that upon exposure to mUA miR-21 expression was decreased and the expression of PTEN and Pdcd4 protein was elevated; In conclusion our data suggest that mUA can suppress cell viability in DU145 cells through modulating miR-21 and its downstream series-wound targets including PTEN Akt and Wnt/β-catenin signaling;miR 21 confers cisplatin resistance in gastric cancer cells by regulating PTEN; In addition miR-21 induced cell survival and cisplatin resistance through downregulating the expression of phosphatase and tension homolog deleted on chromosome 10 PTEN and activation of Akt pathway;Finally we demonstrate that modulation of tumor suppressors PTEN and p53 in U87 cells does not affect the decrease in miR-21 levels associated with PDGF-B overexpression;This study aimed to investigate whether NSCLC miR-21 mediated resistance to TKIs also results from Pten targeting; Here we show miR-21 promotes cancer by negatively regulating Pten expression in human NSCLC tissues: high miR-21 expression levels were associated with shorter DFS in 47 NSCLC patients; high miR-21/low Pten expression levels indicated a poor TKI clinical response and shorter overall survival in another 46 NSCLC patients undergoing TKI treatment; In vitro assays showed that miR-21 was up-regulated concomitantly to down-regulation of Pten in pc-9/GR cells in comparison with pc-9 cells; Moreover over-expression of miR-21 significantly decreased gefitinib sensitivity by down-regulating Pten expression and activating Akt and ERK pathways in pc-9 cells while miR-21 knockdown dramatically restored gefitinib sensitivity of pc-9/GR cells by up-regulation of Pten expression and inactivation of AKT and ERK pathways in vivo and in vitro;MicroRNA 21 miR 21 represses tumor suppressor PTEN and promotes growth and invasion in non small cell lung cancer NSCLC; We identified the role of miR-21 in non-small cell lung cancer NSCLC and to clarify the regulation of PTEN by miR-21 and determine mechanisms of this regulation; Expression of miR-21 and PTEN in 20 paired NSCLC and adjacent non-tumor lung tissues was investigated by qRT-PCR and western blot respectively; Tumor tissues showed an inverse correlation between miR-21 and PTEN protein; miR-21 inhibitor transfection increased a luciferase-reporter activity containing the PTEN-3'-UTR construct and increased PTEN protein but not PTEN-mRNA levels in NSCLC cell lines; miR-21 post-transcriptionally down-regulates the expression of tumor suppressor PTEN and stimulates growth and invasion in NSCLC;MiR-21 overexpression decreases PTEN increases p-Akt and subsequently increases HIF-1α expression while miR-21 inhibition results in increased PTEN decreased p-Akt and then decreased HIF-1α;Furthermore miR-21-induced upregulation of CSF-1 mRNA and its transcription were prevented by expression of PTEN mRNA lacking 3'-untranslated region UTR and miR-21 recognition sequence; Our results reveal a novel mechanism for the therapeutic function of fish oil diet that blocks miR-21 thereby increasing PTEN levels to prevent expression of CSF-1 in breast cancer;This study was aimed to investigate the expression of microRNA-21 and its correlation with PTEN in diffuse large B cell lymphoma DLBCL paraffin-embedded tissues and evaluate its potential relevance with clinical characteristics; In patients with DLBCL the expression level of miR-21 was negatively correlated with the level of PTEN protein; These findings suggest that PTEN is possibly one of the targets of miR-21 in DLBCL;Down regulation of PTEN expression modulated by dysregulated miR 21 contributes to the progression of esophageal cancer; We demonstrated that knockdown of miR-21 significantly increased expression of PTEN protein; Our findings suggest that miR-21 could be a potential oncomiR probably by regulation of PTEN and a novel prognostic factor for ESCC patients;The levels of mir-21 did not associate with the expression of PTEN an important tumour suppressor in CRC and one of many putative targets of miR-21 but interestingly was associated with stage of disease in the PTEN expressing tumours;Anti tumor activity of a novel compound CDF is mediated by regulating miR 21 miR 200 and PTEN in pancreatic cancer; In a xenograft mouse model of human PC CDF treatment significantly inhibited tumor growth which was associated with decreased NF-κB DNA binding activity COX-2 and miR-21 expression and increased PTEN and miR-200 expression in tumor remnants;The PTEN protein levels in CRC tissues and cells had an inverse correlation with miR-21 expression; MiR-21 targets PTEN at the post-transcriptional level and regulates cell proliferation and invasion in CRC;After miR-21 was transfected in MCF-7 cells PTEN protein level was measured by Western blot; Matrine up-regulated PTEN by downregulating miR-21 which in turn dephosphorylated Akt resulting in accumulation of Bad p21/WAF1/CIP1 and p27/KIP1;To further determine the potential involvement of miR-21 in breast cancer we have evaluated the expression level of miR-21 by stem-loop real-time RT-PCR based on SYBR-Green I in human invasive ductal carcinoma of the breast and we have correlated the results with clinicopathologic features and PTEN protein expression; The expression levels of miR-21 were correlated with PTEN and commonly used clinicopathologic features of breast cancer; Expression of miR-21 was negatively correlated with expression of PTEN P=0.013; These findings suggest that PTEN is possibly one of the targets of miR-21 in breast cancer and high expression of mir-21 indicates a more aggressive phenotype;These findings demonstrate a novel role of AR in the regulation of miR-21 and its target PTEN in growth factor-induced colon cancer cell growth;Whether miR-21 regulated PTEN expression was assessed by luciferase assay; The RNA and protein levels of PTEN were significantly decreased by exogenous miR-21 and the 3'-untranslated region of PTEN was shown to be a target of miR-21;In vitro study showed QTsome/AM-21 induced upregulation of miR-21 targets including PTEN and DDAH1 in A549 cells while increasing their sensitivity toward paclitaxel PTX;microRNA 21 overexpression contributes to cell proliferation by targeting PTEN in endometrioid endometrial cancer; We performed a qRT-PCR assay with miR-21 and PTEN in 16 paired EEC tumor tissues and adjacent non-tumor endometrium; To validate the putative binding site of miR-21 in the 3' untranslated region 3'-UTR of PTEN messenger RNA mRNA a dual-luciferase reporter assay was carried out; The upregulation of miR-21 led to a significant decrease in the PTEN protein expression level P=0.007; The downregulation of miR-21 led to a significant increase in PTEN protein P=0.002; In conclusion we demonstrated that the expression of PTEN protein but not mRNA was negatively directly regulated by miR-21 in the KLE cell line; The overexpression of miR-21 modulated EEC cell proliferation through the downregulation of PTEN;The prognostic effect of PTEN expression status in colorectal cancer development and evaluation of factors affecting it: miR 21 and promoter methylation; In this study we investigated the effect of miR-21 and promoter methylation on the PTEN expression status in CRC tissues and analyzed association of the PTEN expression status with clinicopathological features in patients with CRC; PTEN mRNA level was negatively correlated with miR-21 level r = -0.595 P < 0.001; PTEN expression was also correlated directly with the PTEN mRNA level r = 0.583 P < 0.001 and conversely with miR-21 level r = -0.632 P < 0.001; This study suggests a high frequency of miR-21 overexpression and aberrant promoter methylation in down-regulation of PTEN expression in colorectal carcinoma;MicroRNA 21 induces 5 fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4; The proresistance effects of miR-21 were attributed to the attenuated expression of tumor suppressor genes including PTEN and PDCD4;MicroRNA 21 controls hTERT via PTEN in human colorectal cancer cell proliferation; The aim of this study was to determine a role of microRNA-21 miRNA-21 in colorectal cancer CRC and to elucidate miRNA-21 regulation of hTERT by phosphatase and tensin homologue PTEN;Relevance of miR 21 in regulation of tumor suppressor gene PTEN in human cervical cancer cells; We identified the tumor suppressor gene PTEN as a target of miR-21 and determined the mechanism of its regulation throughout reporter construct plasmids; Using this model we analyzed the expression of miR-21 and PTEN as well as functional effects such as autophagy and apoptosis induction; In SiHa cells there was an inverse correlation between miR-21 expression and PTEN mRNA level as well as PTEN protein expression in cervical cancer cells; We conclude that miR-21 post-transcriptionally down-regulates the expression of PTEN to promote cell proliferation and cervical cancer cell survival progression;cell migration;;;;metastasis;differentiation;;tumorigenesis;;drug resistance;;;;;;;;;;;;;;drug resistance;drug resistance;;;;;;drug resistance;;;;;;metastasis;drug resistance;;;;;;;;metastasis;;;;;;;progression;malignant trasformation;;drug resistance;poor survival;;drug resistance;poor survival;;;;;progression;staging;;;;;;;;;;drug resistance;;poor survival liver cancer;liver cancer;liver cancer;liver cancer;breast cancer;gastric cancer;cervical and endocervical cancer;colon cancer;gastric cancer;breast cancer;bladder cancer;glioblastoma;breast cancer;colon cancer;gastric cancer;gastric cancer;colorectal cancer;breast cancer;lung cancer;glioblastoma;melanoma;lung squamous cell cancer;colorectal cancer;lung squamous cell cancer;breast cancer;B cell lymphoma;breast cancer;lung squamous cell cancer;thyroid cancer;breast cancer;breast cancer;esophageal cancer;glioblastoma;cervical and endocervical cancer;esophageal cancer;esophageal cancer;lung squamous cell cancer;pancreatic cancer;lung cancer;esophageal cancer;colon cancer;B cell lymphoma;colon cancer;breast cancer;pancreatic cancer;prostate cancer;lung cancer;gastric cancer;breast cancer;bladder cancer;B cell lymphoma;glioblastoma;prostate cancer;gastric cancer;glioblastoma;lung squamous cell cancer;lung squamous cell cancer;cervical and endocervical cancer;breast cancer;B cell lymphoma;esophageal cancer;colorectal cancer;pancreatic cancer;colorectal cancer;breast cancer;breast cancer;colon cancer;lung squamous cell cancer;lung cancer;endometrial cancer;colorectal cancer;pancreatic cancer;colorectal cancer;cervical and endocervical cancer hsa-miR-455-5p PTGER3 -0.270546034117157 0.0581320703577731 0.469865433429818 0.0709042908017521 miRanda -0.324875894462322 0.000253943923280781 NA NA NA hsa-miR-146b-5p PTGFR 0.419719546795449 0.0457375823220155 -0.0123964951444543 0.979095747348308 miRanda -0.332936650205987 0.00234803214784257 NA NA NA hsa-miR-455-5p PTGFR -0.270546034117157 0.0581320703577731 -0.0123964951444543 0.979095747348308 miRanda -0.360487277591281 0.0261217170258498 NA NA NA hsa-miR-20a-5p PTGFRN 0.854326758727003 5.04256669663285e-07 0.507316306007716 0.00273384618681765 MirTarget;miRNATAP -0.18065095898388 0.000163701302124096 NA NA NA hsa-miR-27b-3p PTGFRN -0.823491817819754 9.20935302746823e-14 0.507316306007716 0.00273384618681765 MirTarget -0.325423895170273 7.44333339912034e-06 NA NA NA hsa-miR-30c-5p PTGFRN -0.432111642767632 0.000159764714931007 0.507316306007716 0.00273384618681765 MirTarget;miRNATAP -0.165789691402466 0.0221412299601048 NA NA NA hsa-miR-30e-5p PTGFRN -0.627815042856657 3.02205690184908e-10 0.507316306007716 0.00273384618681765 MirTarget -0.376683886338336 3.71577327564791e-06 NA NA NA hsa-miR-455-5p PTGFRN -0.270546034117157 0.0581320703577731 0.507316306007716 0.00273384618681765 MirTarget;miRanda;miRNATAP -0.304696859904942 1.13281426738934e-07 NA NA NA hsa-miR-29c-3p PTHLH -1.4367517608807 1.61767774905781e-21 1.18418240379439 0.00181078859052455 MirTarget -0.548905210937142 2.37742693690382e-06 NA NA NA hsa-miR-455-5p PTHLH -0.270546034117157 0.0581320703577731 1.18418240379439 0.00181078859052455 miRanda -0.274850386058098 0.0356354057816587 NA NA NA hsa-miR-20a-5p PTK2B 0.854326758727003 5.04256669663285e-07 -0.700590373264672 3.98424408987687e-08 mirMAP -0.126201135304202 0.000561193767707289 NA NA NA hsa-miR-34a-5p PTMS 1.03694231790865 5.74864019540594e-14 -0.992988085020651 1.37259745462155e-11 miRNAWalker2_validate -0.106571369595482 0.0396459847197291 NA NA NA hsa-miR-455-5p PTP4A2 -0.270546034117157 0.0581320703577731 -0.253788497636468 0.0014163295001538 MirTarget;PITA;miRanda;miRNATAP -0.181091565760803 9.68898200262741e-12 NA NA NA hsa-miR-192-5p PTP4A3 -0.50188499512787 0.00344713341196035 1.98288212330108 7.95134226476913e-18 miRNAWalker2_validate -0.393838101836757 4.31264740267398e-09 NA NA NA hsa-miR-181a-5p PTPN11 0.250113435902954 0.0551933249319293 -0.324998377632372 0.000647318034968802 miRNAWalker2_validate;miRTarBase -0.10436975560246 0.00355721073615052 NA NA NA hsa-miR-194-5p PTPN12 -0.292530160992458 0.0996141384876663 0.175155862696809 0.0513645273204438 miRNAWalker2_validate;miRTarBase -0.103584990859615 2.2884966147973e-05 27486333 Meanwhile bioinformatics tools were used to identify protein tyrosine phosphatase nonreceptor type 12 PTPN12 as a potential target of miR-194; The luciferase assay showed that miR-194 directly binds to the 3'-untranslated region of PTPN12; Western blot analysis and quantitative real-time polymerase chain reaction assay revealed that PTPN12 expression was negatively associated with miR-194 expression in both ovarian cancer tissues and cells; Thus we conclude that miR-194 targets PTPN12 and functions as an oncogene in ovarian cancer cells ovarian cancer hsa-miR-194-5p PTPN13 -0.292530160992458 0.0996141384876663 -2.49193507140468 1.28808676407305e-16 miRNAWalker2_validate;miRTarBase -0.775495082337471 3.04502639157388e-21 NA NA NA hsa-miR-455-5p PTPN13 -0.270546034117157 0.0581320703577731 -2.49193507140468 1.28808676407305e-16 miRanda -0.458080426472331 1.70349907216673e-05 NA NA NA hsa-miR-148a-3p PTPN14 -0.748702855596996 3.93313343865641e-07 0.635943426312836 0.000736881269593778 MirTarget;miRNATAP -0.430598688156951 9.08169553450041e-13 NA NA NA hsa-miR-15a-5p PTPN14 0.349521211668244 0.000770735998804736 0.635943426312836 0.000736881269593778 MirTarget -0.176859330408098 0.0478324429095268 NA NA NA hsa-miR-27b-3p PTPN14 -0.823491817819754 9.20935302746823e-14 0.635943426312836 0.000736881269593778 mirMAP -0.181913956809451 0.0259456455872694 NA NA NA hsa-miR-21-5p PTPN3 1.51084295924322 1.54551622173259e-34 -1.09679913983405 1.08772189092188e-15 miRNAWalker2_validate -0.346268834460471 7.08819192499444e-12 NA NA NA hsa-miR-15a-5p PTPN4 0.349521211668244 0.000770735998804736 -0.276283887533269 0.00146605292632864 miRNATAP -0.128968600148284 0.00159716375103857 NA NA NA hsa-miR-19b-3p PTPN4 0.601279551368824 0.00016685097085251 -0.276283887533269 0.00146605292632864 miRNAWalker2_validate -0.140430933950907 6.99721046323096e-08 NA NA NA hsa-miR-20a-5p PTPN4 0.854326758727003 5.04256669663285e-07 -0.276283887533269 0.00146605292632864 miRNATAP -0.139494556721343 8.61866201678084e-09 NA NA NA hsa-miR-21-5p PTPRB 1.51084295924322 1.54551622173259e-34 -1.32542877067513 1.77250908183134e-12 mirMAP -0.468187150825792 1.0789974921566e-11 NA NA NA hsa-miR-224-3p PTPRB 1.40770116795301 1.31426607144612e-08 -1.32542877067513 1.77250908183134e-12 mirMAP -0.117069983397373 0.00194439674413185 NA NA NA hsa-miR-194-5p PTPRD -0.292530160992458 0.0996141384876663 -2.42193981889629 1.33671056298661e-09 miRNATAP -0.226845274227427 0.0432989123065285 NA NA NA hsa-miR-19b-3p PTPRD 0.601279551368824 0.00016685097085251 -2.42193981889629 1.33671056298661e-09 miRNATAP -0.559911691883816 5.2147299124861e-06 NA NA NA hsa-miR-20a-5p PTPRD 0.854326758727003 5.04256669663285e-07 -2.42193981889629 1.33671056298661e-09 miRNATAP -0.578847888078726 4.0858725271912e-07 NA NA NA hsa-miR-192-5p PTPRE -0.50188499512787 0.00344713341196035 -0.302082448360899 0.0921369971160767 miRNAWalker2_validate -0.464635712302489 7.26899889346159e-22 NA NA NA hsa-miR-455-5p PTPRE -0.270546034117157 0.0581320703577731 -0.302082448360899 0.0921369971160767 miRanda -0.369001063769217 9.41840136329977e-10 NA NA NA hsa-miR-19b-3p PTPRG 0.601279551368824 0.00016685097085251 0.490912263823608 0.00324856263309075 miRNAWalker2_validate;MirTarget;miRNATAP -0.216432670603908 1.81008307335457e-05 27602768 MiR 19b suppresses PTPRG to promote breast tumorigenesis; We identified two specific binding sites for miR-19b in the 3'-untranslated region of PTPRG; We further identified an inverse correlation between miR-19b and PTPRG protein levels but not mRNA levels in human breast cancer tissues; By overexpressing or knocking down miR-19b in MCF-7 cells and MDA-231 cells we experimentally confirmed that miR-19b directly suppresses PTPRG expression; Furthermore we determined that the inhibition of PTPRG by miR-19b leads to increased proliferation stimulated cell migration and reduced apoptosis; Taken together our findings provide the first evidence that miR-19b inhibits PTPRG expression to promote tumorigenesis in human breast cancer tumorigenesis;cell migration breast cancer hsa-miR-148a-3p PTPRM -0.748702855596996 3.93313343865641e-07 0.0121830472151929 0.941670599603893 miRNATAP -0.257137605577313 1.74355883677486e-06 NA NA NA hsa-miR-20a-5p PTPRO 0.854326758727003 5.04256669663285e-07 -0.996319312073661 7.79820271688871e-06 miRNATAP -0.199817582784959 0.00170645067303651 NA NA NA hsa-miR-20a-5p PTPRS 0.854326758727003 5.04256669663285e-07 -2.31690961469515 2.64772737951824e-10 miRNAWalker2_validate -0.268396673286502 0.0115891346482372 NA NA NA hsa-miR-224-3p PTPRS 1.40770116795301 1.31426607144612e-08 -2.31690961469515 2.64772737951824e-10 mirMAP -0.275437367385569 0.000165920094700402 NA NA NA hsa-miR-21-5p PTPRT 1.51084295924322 1.54551622173259e-34 -1.89012666330824 4.99769771079087e-07 mirMAP -0.410670273096541 0.00313629325312729 NA NA NA hsa-miR-20a-5p PTRF 0.854326758727003 5.04256669663285e-07 0.145511639550823 0.264171131706134 mirMAP -0.227506046545491 3.05076642288136e-10 NA NA NA hsa-miR-132-3p PUM2 0.323796239695997 0.00272093067935091 -0.121610492133464 0.0463266511286663 miRNATAP -0.152474736078803 1.72227784083236e-08 NA NA NA hsa-miR-15a-5p PURA 0.349521211668244 0.000770735998804736 -0.370395647075075 1.00532282271468e-06 miRNAWalker2_validate;miRTarBase;MirTarget -0.131628603706365 0.000235881459463138 NA NA NA hsa-miR-21-5p PURA 1.51084295924322 1.54551622173259e-34 -0.370395647075075 1.00532282271468e-06 miRNAWalker2_validate -0.198963437888801 1.97908484987669e-13 NA NA NA hsa-miR-455-5p PVT1 -0.270546034117157 0.0581320703577731 2.64525352380863 4.53868311230541e-19 miRanda -0.198996642949821 0.0128250741280512 NA NA NA hsa-miR-192-5p PXDN -0.50188499512787 0.00344713341196035 -0.804786342551695 2.16750749800913e-06 miRNAWalker2_validate -0.352969347724555 8.82059106206006e-14 NA NA NA hsa-miR-19b-3p PXDN 0.601279551368824 0.00016685097085251 -0.804786342551695 2.16750749800913e-06 MirTarget -0.199184940878378 0.000126374566950281 NA NA NA hsa-miR-20a-5p PXDN 0.854326758727003 5.04256669663285e-07 -0.804786342551695 2.16750749800913e-06 MirTarget -0.265143082102066 3.33210281270668e-08 NA NA NA hsa-miR-503-5p PYCRL 0.191949282338049 0.268420664548092 0.830809890342951 7.37352070902481e-10 mirMAP -0.178265709976064 3.50839526594746e-06 NA NA NA hsa-miR-505-5p PYGO2 -0.768282569967001 1.14662846595407e-05 1.17890176614 2.86682262433208e-35 MirTarget -0.112418853411873 7.68254636317826e-05 NA NA NA hsa-miR-146b-5p QSOX1 0.419719546795449 0.0457375823220155 -0.998176284579899 0.000345773632396881 miRanda -0.20676968607399 0.00145889137327504 NA NA NA hsa-miR-192-3p QSOX1 -0.6401165114007 0.000266272092403814 -0.998176284579899 0.000345773632396881 mirMAP -0.520172288134819 6.48887635107979e-12 NA NA NA hsa-miR-192-5p QSOX1 -0.50188499512787 0.00344713341196035 -0.998176284579899 0.000345773632396881 mirMAP -0.556359066488718 7.12939650913052e-13 NA NA NA hsa-miR-34a-5p QSOX1 1.03694231790865 5.74864019540594e-14 -0.998176284579899 0.000345773632396881 mirMAP -0.644990627282221 7.46441108185982e-12 NA NA NA hsa-miR-30b-5p R3HDM1 -0.54056186708617 2.44688760798341e-05 0.700621654495913 2.64479014619206e-19 MirTarget -0.157502441146718 2.2982258585959e-07 NA NA NA hsa-miR-148a-3p RAB10 -0.748702855596996 3.93313343865641e-07 0.283852356286084 7.31286137720053e-05 miRNAWalker2_validate -0.101607342652178 1.24328558037831e-05 NA NA NA hsa-miR-146b-5p RAB11FIP1 0.419719546795449 0.0457375823220155 0.108952592671093 0.533553281978569 mirMAP -0.114148440193791 0.00480268994622072 NA NA NA hsa-miR-19b-3p RAB11FIP1 0.601279551368824 0.00016685097085251 0.108952592671093 0.533553281978569 mirMAP -0.117773961950627 0.0266660012066136 NA NA NA hsa-miR-181a-5p RAB11FIP2 0.250113435902954 0.0551933249319293 0.0463066186430496 0.661781012741478 mirMAP;miRNATAP -0.152649347741898 0.000106184557939951 NA NA NA hsa-miR-181b-5p RAB11FIP2 0.488256489401108 0.00105321129419701 0.0463066186430496 0.661781012741478 mirMAP;miRNATAP -0.152200762243869 8.36787296373822e-06 NA NA NA hsa-miR-21-5p RAB11FIP2 1.51084295924322 1.54551622173259e-34 0.0463066186430496 0.661781012741478 miRNAWalker2_validate -0.129344121684595 0.000750313312053913 NA NA NA hsa-miR-29c-3p RAB11FIP4 -1.4367517608807 1.61767774905781e-21 1.54437373311846 7.02562100479325e-17 mirMAP -0.424467411550964 1.70550428982485e-13 NA NA NA hsa-miR-505-5p RAB11FIP4 -0.768282569967001 1.14662846595407e-05 1.54437373311846 7.02562100479325e-17 mirMAP -0.265910660282129 4.14890439628992e-07 NA NA NA hsa-miR-20a-5p RAB11FIP5 0.854326758727003 5.04256669663285e-07 0.00512755246580143 0.969958157879948 MirTarget -0.135236885140177 0.000420517251326306 NA NA NA hsa-miR-29c-3p RAB15 -1.4367517608807 1.61767774905781e-21 0.191761348491017 0.18349645899402 miRNATAP -0.188135173967727 1.91515402187283e-05 NA NA NA hsa-miR-30c-5p RAB15 -0.432111642767632 0.000159764714931007 0.191761348491017 0.18349645899402 miRNATAP -0.176206991416358 0.00404297610439729 NA NA NA hsa-miR-30e-5p RAB15 -0.627815042856657 3.02205690184908e-10 0.191761348491017 0.18349645899402 miRNATAP -0.335246938499101 1.14008726351984e-06 NA NA NA hsa-miR-181a-5p RAB18 0.250113435902954 0.0551933249319293 -0.46249405944098 4.04460036073819e-11 mirMAP -0.121243132302688 4.9242925050504e-06 NA NA NA hsa-miR-19b-3p RAB18 0.601279551368824 0.00016685097085251 -0.46249405944098 4.04460036073819e-11 MirTarget;miRNATAP -0.100551493833286 2.82124918364429e-06 NA NA NA hsa-miR-192-5p RAB23 -0.50188499512787 0.00344713341196035 0.527982849286996 2.90025934855642e-07 miRNAWalker2_validate -0.15913992868139 4.61556135952921e-08 NA NA NA hsa-miR-192-5p RAB27B -0.50188499512787 0.00344713341196035 -0.982992130812183 0.00316826721508081 MirTarget -0.268391347828475 0.00462724907433718 NA NA NA hsa-miR-20a-5p RAB30 0.854326758727003 5.04256669663285e-07 -0.688840167280648 5.94886883391515e-06 mirMAP;miRNATAP -0.235096722416388 4.36557436475802e-08 NA NA NA hsa-miR-21-5p RAB30 1.51084295924322 1.54551622173259e-34 -0.688840167280648 5.94886883391515e-06 mirMAP -0.331290882284831 1.82601971707362e-09 NA NA NA hsa-miR-455-5p RAB31 -0.270546034117157 0.0581320703577731 -0.356598891460701 0.0310816261207448 miRanda -0.384866164994697 3.40849227266419e-12 NA NA NA hsa-miR-455-5p RAB33A -0.270546034117157 0.0581320703577731 -0.0359653307262704 0.863152040475096 miRanda -0.160934058695241 0.0242422670799846 NA NA NA hsa-miR-19b-3p RAB33B 0.601279551368824 0.00016685097085251 -0.971571032808348 1.9063931644726e-16 MirTarget;miRNATAP -0.132661253174432 0.000347098350334255 NA NA NA hsa-miR-148a-3p RAB34 -0.748702855596996 3.93313343865641e-07 0.412870987704762 0.126202873299987 miRNAWalker2_validate;MirTarget;miRNATAP -0.797089078971911 2.39755456296972e-21 NA NA NA hsa-miR-148a-3p RAB35 -0.748702855596996 3.93313343865641e-07 0.223741416752273 0.000176271000804346 miRNATAP -0.103218271982733 7.43644180741036e-08 NA NA NA hsa-miR-224-3p RAB36 1.40770116795301 1.31426607144612e-08 -1.40003875754033 7.76365843922162e-07 mirMAP -0.157766417008524 0.00499516505939397 NA NA NA hsa-miR-27b-3p RAB3B -0.823491817819754 9.20935302746823e-14 2.31148128583348 9.51479131264821e-10 miRNAWalker2_validate -0.656563986473433 7.22157614610585e-05 NA NA NA hsa-miR-29c-3p RAB3B -1.4367517608807 1.61767774905781e-21 2.31148128583348 9.51479131264821e-10 mirMAP -0.402500422031992 0.000680095462241964 NA NA NA hsa-miR-30c-5p RAB3B -0.432111642767632 0.000159764714931007 2.31148128583348 9.51479131264821e-10 mirMAP -0.595355564167132 0.000279333357294567 NA NA NA hsa-miR-30e-5p RAB3B -0.627815042856657 3.02205690184908e-10 2.31148128583348 9.51479131264821e-10 mirMAP -0.579996445166243 0.00184629361651035 NA NA NA hsa-miR-455-3p RAB3D -1.3998033821095 5.72010709806871e-17 0.773304623493939 0.0020137981864917 mirMAP -0.22402497731369 0.00147302158538018 NA NA NA hsa-miR-30e-5p RAB4B -0.627815042856657 3.02205690184908e-10 0.30220322555064 0.00188001332273077 MirTarget -0.207284542796006 9.00524061205028e-06 NA NA NA hsa-miR-21-5p RAB6A 1.51084295924322 1.54551622173259e-34 -0.425231925971688 6.4816140566381e-09 miRNAWalker2_validate;miRNATAP -0.10348788977009 0.000122896644917287 NA NA NA hsa-miR-148a-3p RAB6B -0.748702855596996 3.93313343865641e-07 1.14011669130437 2.23537791600293e-14 mirMAP -0.580164632188529 3.02823853653868e-36 NA NA NA hsa-miR-15a-5p RAB6B 0.349521211668244 0.000770735998804736 1.14011669130437 2.23537791600293e-14 mirMAP -0.155758215846156 0.0322569925911611 NA NA NA hsa-miR-194-5p RAB6B -0.292530160992458 0.0996141384876663 1.14011669130437 2.23537791600293e-14 miRNATAP -0.448765375093006 5.22744169259714e-30 NA NA NA hsa-miR-29c-3p RAB6B -1.4367517608807 1.61767774905781e-21 1.14011669130437 2.23537791600293e-14 mirMAP;miRNATAP -0.232010026705719 7.80285559400286e-07 NA NA NA hsa-miR-455-3p RAB6B -1.3998033821095 5.72010709806871e-17 1.14011669130437 2.23537791600293e-14 mirMAP -0.340633303522601 3.49621587892217e-16 NA NA NA hsa-miR-21-5p RAB6C 1.51084295924322 1.54551622173259e-34 -0.589269355987388 5.0901403406691e-07 miRNAWalker2_validate -0.156086876111219 0.000298090383111658 NA NA NA hsa-miR-17-3p RAB8B 0.410352776142368 0.00422200500748636 -0.221321521910201 0.0455526239538757 MirTarget;miRNATAP -0.116688244549162 0.0018690224206446 NA NA NA hsa-miR-20a-5p RAB8B 0.854326758727003 5.04256669663285e-07 -0.221321521910201 0.0455526239538757 miRNATAP -0.114857641117294 0.000231473698986588 NA NA NA hsa-miR-15a-5p RAB9A 0.349521211668244 0.000770735998804736 -0.195672682668297 0.0188690572428822 MirTarget -0.154136208951286 7.57421589650611e-05 NA NA NA hsa-miR-30c-5p RABIF -0.432111642767632 0.000159764714931007 0.834139340149566 3.27899432577764e-21 mirMAP -0.189505862561849 1.2022417884095e-06 NA NA NA hsa-miR-30e-5p RABIF -0.627815042856657 3.02205690184908e-10 0.834139340149566 3.27899432577764e-21 mirMAP -0.293859206681785 1.79236832411362e-11 NA NA NA hsa-miR-192-5p RACGAP1 -0.50188499512787 0.00344713341196035 2.47619748809122 3.80949763818893e-47 miRNAWalker2_validate -0.138545140214855 0.0114048690297015 NA NA NA hsa-miR-215-5p RACGAP1 -0.981544773246509 3.14452272477156e-05 2.47619748809122 3.80949763818893e-47 miRNAWalker2_validate -0.139001142307992 0.000420991841323929 NA NA NA hsa-miR-181a-5p RAD23B 0.250113435902954 0.0551933249319293 -0.349483835523183 2.52871873211643e-06 MirTarget -0.142840170017388 2.53939039536105e-07 NA NA NA hsa-miR-181b-5p RAD23B 0.488256489401108 0.00105321129419701 -0.349483835523183 2.52871873211643e-06 MirTarget -0.163805029928495 6.0022065657963e-12 NA NA NA hsa-miR-15a-5p RAD50 0.349521211668244 0.000770735998804736 0.172525089765549 0.0739985477348335 MirTarget -0.107316521684857 0.0181008932467063 NA NA NA hsa-miR-192-5p RAD51 -0.50188499512787 0.00344713341196035 2.44239687577714 3.5869762404792e-29 miRNAWalker2_validate -0.23074588667787 0.000486619447404882 NA NA NA hsa-miR-215-5p RAD51 -0.981544773246509 3.14452272477156e-05 2.44239687577714 3.5869762404792e-29 miRNAWalker2_validate -0.135092544623591 0.00480614982904731 NA NA NA hsa-miR-192-5p RAD54B -0.50188499512787 0.00344713341196035 1.72250911173302 8.3954343136252e-30 miRNAWalker2_validate -0.137500588773377 0.00295771914695639 NA NA NA hsa-miR-215-5p RAD54B -0.981544773246509 3.14452272477156e-05 1.72250911173302 8.3954343136252e-30 miRNAWalker2_validate -0.143042557137272 1.67025153896514e-05 NA NA NA hsa-miR-192-5p RADIL -0.50188499512787 0.00344713341196035 0.126144548325969 0.541753255795591 miRNAWalker2_validate -0.372271575053115 8.32754240117811e-11 NA NA NA hsa-miR-20a-5p RAG1 0.854326758727003 5.04256669663285e-07 -1.83334993331865 5.88133623260973e-11 mirMAP -0.453043947075455 1.54036134393619e-08 NA NA NA hsa-miR-194-5p RAI1 -0.292530160992458 0.0996141384876663 0.299976497612845 0.0203059955454792 miRNATAP -0.253205212140561 2.33185411991069e-13 NA NA NA hsa-miR-34a-5p RAI14 1.03694231790865 5.74864019540594e-14 0.0287063275824053 0.787204267049909 MirTarget -0.157969170966346 1.22345610951493e-05 NA NA NA hsa-miR-19b-3p RAI2 0.601279551368824 0.00016685097085251 -1.08948748698881 1.5782799770325e-07 miRNATAP -0.366786943868203 5.96996822553934e-09 NA NA NA hsa-miR-455-5p RAI2 -0.270546034117157 0.0581320703577731 -1.08948748698881 1.5782799770325e-07 miRanda -0.280038131199438 9.73994290811279e-05 NA NA NA hsa-miR-27b-3p RALA -0.823491817819754 9.20935302746823e-14 0.356889705448643 1.15054362861669e-08 miRNATAP -0.128080206262242 1.99992119450621e-06 NA NA NA hsa-miR-29c-3p RALA -1.4367517608807 1.61767774905781e-21 0.356889705448643 1.15054362861669e-08 miRNATAP -0.145205627535117 1.25874038751213e-14 NA NA NA hsa-miR-192-5p RALB -0.50188499512787 0.00344713341196035 -0.133157006154685 0.074563715411608 MirTarget -0.149704404771039 2.69040263284912e-13 NA NA NA hsa-miR-30b-5p RALGAPA2 -0.54056186708617 2.44688760798341e-05 -0.873507838249481 0.000487057852802789 mirMAP -0.225637698152022 0.0182436385024564 NA NA NA hsa-miR-146b-5p RALGPS1 0.419719546795449 0.0457375823220155 0.376167916836608 0.081230746695397 miRanda -0.112877807540741 0.0242256747995302 NA NA NA hsa-miR-148a-3p RALGPS1 -0.748702855596996 3.93313343865641e-07 0.376167916836608 0.081230746695397 mirMAP -0.16344418084918 0.0205836280387605 NA NA NA hsa-miR-194-5p RALGPS1 -0.292530160992458 0.0996141384876663 0.376167916836608 0.081230746695397 miRNATAP -0.138514318290346 0.0195913688591281 NA NA NA hsa-miR-21-5p RALGPS2 1.51084295924322 1.54551622173259e-34 -0.265145862108441 0.0452541902055679 miRNAWalker2_validate;MirTarget -0.298500023178292 2.94960664606271e-10 NA NA NA hsa-miR-30c-5p RAN -0.432111642767632 0.000159764714931007 0.604104001869836 9.24839787661052e-12 mirMAP -0.131963728564753 0.000607641554417456 NA NA NA hsa-miR-20a-5p RANBP10 0.854326758727003 5.04256669663285e-07 -0.164752457150059 0.142653302199525 mirMAP -0.12442572190602 8.25010664355178e-05 NA NA NA hsa-miR-20b-5p RANBP10 0.457668023910379 0.0285865211936156 -0.164752457150059 0.142653302199525 mirMAP -0.107976367869664 3.16422146507241e-05 NA NA NA hsa-miR-222-3p RANBP10 1.08574156066353 1.76407192348131e-11 -0.164752457150059 0.142653302199525 miRNAWalker2_validate -0.219063369200428 1.21408704957977e-11 NA NA NA hsa-miR-148a-3p RANGAP1 -0.748702855596996 3.93313343865641e-07 0.368298574723631 0.00096323372819063 MirTarget -0.276509616318188 5.75616246983203e-15 NA NA NA hsa-miR-455-3p RAP1GAP2 -1.3998033821095 5.72010709806871e-17 -0.150407243792527 0.591682167346389 mirMAP -0.304954759832306 9.68215791912027e-05 NA NA NA hsa-miR-30e-5p RAP2B -0.627815042856657 3.02205690184908e-10 0.0346031297557046 0.72839574434053 mirMAP -0.253202706049665 8.86063741377848e-08 NA NA NA hsa-miR-17-3p RAP2C 0.410352776142368 0.00422200500748636 -0.410431451936733 9.12222531349358e-05 MirTarget;miRNATAP -0.132276946261806 0.000210815679974546 NA NA NA hsa-miR-20a-5p RAP2C 0.854326758727003 5.04256669663285e-07 -0.410431451936733 9.12222531349358e-05 MirTarget;miRNATAP -0.126263809564664 2.08756964298057e-05 NA NA NA hsa-miR-15a-5p RAPGEF2 0.349521211668244 0.000770735998804736 -0.707388543717723 1.66316838166028e-08 miRNATAP -0.215335862739807 0.000315799124198883 NA NA NA hsa-miR-19b-3p RAPGEF2 0.601279551368824 0.00016685097085251 -0.707388543717723 1.66316838166028e-08 MirTarget;miRNATAP -0.1802486786036 2.58290295267383e-06 NA NA NA hsa-miR-20a-5p RAPGEF2 0.854326758727003 5.04256669663285e-07 -0.707388543717723 1.66316838166028e-08 MirTarget;miRNATAP -0.209073810761206 3.83769964779062e-09 NA NA NA hsa-miR-21-5p RAPGEF6 1.51084295924322 1.54551622173259e-34 -0.492574631515547 0.0475932470995822 miRNAWalker2_validate -0.275740488474668 0.00236685464406788 NA NA NA hsa-miR-30b-5p RAPGEF6 -0.54056186708617 2.44688760798341e-05 -0.492574631515547 0.0475932470995822 mirMAP -0.260268901928948 0.00578858119317417 NA NA NA hsa-miR-29c-3p RAPGEFL1 -1.4367517608807 1.61767774905781e-21 0.512757940233236 0.00610377319567469 miRNATAP -0.256808985720801 7.28993976728275e-06 NA NA NA hsa-miR-132-3p RAPH1 0.323796239695997 0.00272093067935091 -0.828501491561341 2.21189027809936e-08 mirMAP -0.518397583330735 4.36318471867684e-15 NA NA NA hsa-miR-21-5p RAPH1 1.51084295924322 1.54551622173259e-34 -0.828501491561341 2.21189027809936e-08 miRNAWalker2_validate;mirMAP -0.502969139994053 5.88322638281878e-22 NA NA NA hsa-miR-221-3p RAPH1 1.12244756358612 3.48370308238012e-13 -0.828501491561341 2.21189027809936e-08 mirMAP -0.245161829914477 7.98532935115403e-08 NA NA NA hsa-miR-222-3p RAPH1 1.08574156066353 1.76407192348131e-11 -0.828501491561341 2.21189027809936e-08 mirMAP -0.241778940581349 3.34832246770653e-08 NA NA NA hsa-miR-146b-5p RARA 0.419719546795449 0.0457375823220155 0.26381183745838 0.00504882339445867 miRanda -0.113842988881595 1.2506902289011e-07 NA NA NA hsa-miR-15a-5p RARB 0.349521211668244 0.000770735998804736 -1.31143497176009 3.56699995885221e-11 miRNATAP -0.275481223442223 0.00393412422735751 NA NA NA hsa-miR-20a-5p RARB 0.854326758727003 5.04256669663285e-07 -1.31143497176009 3.56699995885221e-11 miRNATAP -0.321109319269754 1.43912137729233e-08 NA NA NA hsa-miR-455-3p RARB -1.3998033821095 5.72010709806871e-17 -1.31143497176009 3.56699995885221e-11 PITA;miRNATAP -0.130500008339662 0.0220843453702903 NA NA NA hsa-miR-30e-5p RARG -0.627815042856657 3.02205690184908e-10 0.216124249904593 0.113960222085446 MirTarget -0.348884840463176 8.60690733401777e-08 NA NA NA hsa-miR-505-5p RARG -0.768282569967001 1.14662846595407e-05 0.216124249904593 0.113960222085446 MirTarget -0.101302863314137 0.00719018484117138 NA NA NA hsa-miR-99a-5p RARS -1.51481656384839 3.93230057259529e-14 0.386808833706126 4.26844186397357e-08 miRNAWalker2_validate -0.115353564157447 1.92820087386386e-12 NA NA NA hsa-miR-21-5p RASA1 1.51084295924322 1.54551622173259e-34 -0.0728742068751655 0.561743113598097 miRNATAP -0.101935589192876 0.0258841950427365 25663768;27101583 RKO cells were transfected with vectors overexpressing or down-regulating either miR-21 or RASA1; Furthermore a luciferase reporter assay was used to determine whether RASA1 is a gene target of miR-21; RASA1 protein levels were significantly decreased in RKO cells compared with the other 5 colon cancer cell lines and RASA1 was confirmed as a target gene of miR-21; Interestingly RASA1 mRNA and protein levels in pre-miR-21-LV up-regulation of miR-21 cells were lower than those in anti-miR-21-LV down-regulation of miR-21 cells P < 0.05; RASA1 is a target gene of miR-21 which promotes malignant behaviors of RKO cells through regulation of RASA1 expression;Circulating MicroRNA 21 Is Involved in Lymph Node Metastasis in Cervical Cancer by Targeting RASA1; Then cervical cancer cell lines HeLa HPV-18 DNA E6/E7RNA and HT-3 HPV DNA E6/E7RNA were used to confirm the interaction between miR-21 and RASA1; MicroRNA-21 reduces RASA1 expression in cervical cancer cell lines and promotes cervical cancer cell migration via RASA1 malignant trasformation;metastasis;cell migration colon cancer;cervical and endocervical cancer hsa-miR-30b-5p RASA1 -0.54056186708617 2.44688760798341e-05 -0.0728742068751655 0.561743113598097 MirTarget -0.161690428976581 0.000636074752042687 NA NA NA hsa-miR-30b-5p RASA2 -0.54056186708617 2.44688760798341e-05 -0.727100402961242 0.00330690041503877 mirMAP -0.20123856436322 0.0328767891660269 NA NA NA hsa-miR-29c-3p RASAL2 -1.4367517608807 1.61767774905781e-21 0.540621829902408 6.96559685302098e-05 MirTarget -0.101619256255681 0.015904072299387 NA NA NA hsa-miR-20a-5p RASD1 0.854326758727003 5.04256669663285e-07 -1.80141635813111 2.33478853508858e-09 MirTarget -0.344283302448969 7.1988869539664e-05 NA NA NA hsa-miR-20b-5p RASD1 0.457668023910379 0.0285865211936156 -1.80141635813111 2.33478853508858e-09 MirTarget -0.217339585231973 0.0023891487010502 NA NA NA hsa-miR-455-5p RASEF -0.270546034117157 0.0581320703577731 8.91335617283495e-05 0.999844830596708 miRanda -0.36914491471528 0.0186677668023423 NA NA NA hsa-miR-17-3p RASGEF1B 0.410352776142368 0.00422200500748636 -2.40154618069155 1.29739869332177e-25 MirTarget -0.339946785410389 3.85242378389622e-05 NA NA NA hsa-miR-19b-3p RASGEF1B 0.601279551368824 0.00016685097085251 -2.40154618069155 1.29739869332177e-25 mirMAP -0.313173282074193 2.17442669594715e-05 NA NA NA hsa-miR-20a-5p RASGEF1B 0.854326758727003 5.04256669663285e-07 -2.40154618069155 1.29739869332177e-25 mirMAP -0.414444961508052 1.10248244442407e-09 NA NA NA hsa-miR-20b-5p RASGEF1B 0.457668023910379 0.0285865211936156 -2.40154618069155 1.29739869332177e-25 mirMAP -0.124896971993369 0.0283979717071826 NA NA NA hsa-miR-148a-3p RASGRP1 -0.748702855596996 3.93313343865641e-07 -0.453717444218552 0.0529724316830882 MirTarget -0.453369512761064 1.78337663608658e-09 NA NA NA hsa-miR-34a-5p RASGRP4 1.03694231790865 5.74864019540594e-14 -1.28007060385661 1.33669859072194e-14 MirTarget -0.130282311803738 0.0274425711105352 NA NA NA hsa-miR-192-3p RASL11B -0.6401165114007 0.000266272092403814 -1.43422303010254 2.46646129541877e-05 MirTarget -0.584106459533257 3.41590313624754e-10 NA NA NA hsa-miR-20a-5p RASL11B 0.854326758727003 5.04256669663285e-07 -1.43422303010254 2.46646129541877e-05 MirTarget;miRNATAP -0.312615395724908 0.00127966080512951 NA NA NA hsa-miR-30c-5p RASL12 -0.432111642767632 0.000159764714931007 2.22348331254447 5.19610169875086e-37 miRNATAP -0.277604179125707 0.000655315255875746 NA NA NA hsa-miR-17-3p RASSF2 0.410352776142368 0.00422200500748636 -0.691373209584495 1.83971460491871e-05 mirMAP -0.139275604744056 0.0119016920357616 NA NA NA hsa-miR-192-3p RASSF2 -0.6401165114007 0.000266272092403814 -0.691373209584495 1.83971460491871e-05 mirMAP -0.385023077478215 4.07766024559668e-19 NA NA NA hsa-miR-19b-3p RASSF2 0.601279551368824 0.00016685097085251 -0.691373209584495 1.83971460491871e-05 miRNAWalker2_validate;MirTarget -0.121852476449389 0.0138164546798989 NA NA NA hsa-miR-20a-5p RASSF2 0.854326758727003 5.04256669663285e-07 -0.691373209584495 1.83971460491871e-05 MirTarget;miRNATAP -0.17826863778782 0.000103234837686686 NA NA NA hsa-miR-17-3p RASSF6 0.410352776142368 0.00422200500748636 -0.748768474661194 0.0102981957577591 MirTarget -0.479397024124286 1.13425422392804e-06 NA NA NA hsa-miR-20a-5p RASSF6 0.854326758727003 5.04256669663285e-07 -0.748768474661194 0.0102981957577591 mirMAP -0.416341562516064 3.8189794404351e-07 NA NA NA hsa-miR-148a-3p RASSF8 -0.748702855596996 3.93313343865641e-07 -0.720252468942172 0.000203633435082961 miRNAWalker2_validate;miRNATAP -0.252322899887963 6.96701184447254e-05 NA NA NA hsa-miR-192-5p RASSF8 -0.50188499512787 0.00344713341196035 -0.720252468942172 0.000203633435082961 miRNAWalker2_validate -0.294655537239289 6.82278712632995e-08 NA NA NA hsa-miR-99a-5p RAVER2 -1.51481656384839 3.93230057259529e-14 0.515366330391388 0.0259310601480161 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.299661846923993 2.6387128598997e-08 NA NA NA hsa-miR-20a-5p RB1 0.854326758727003 5.04256669663285e-07 -0.431695598029404 0.00179279020523563 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.144090309816489 0.000231958406673791 NA NA NA hsa-miR-21-5p RB1 1.51084295924322 1.54551622173259e-34 -0.431695598029404 0.00179279020523563 miRNAWalker2_validate -0.130479458630801 0.00994795669328339 NA NA NA hsa-miR-455-5p RB1CC1 -0.270546034117157 0.0581320703577731 0.296094195856814 0.0137714544143897 miRanda -0.100558847038998 0.0146618829908621 NA NA NA hsa-miR-20a-5p RBL2 0.854326758727003 5.04256669663285e-07 -0.988381422306337 9.82564074336519e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.264295882999639 1.60446558088321e-10 NA NA NA hsa-miR-192-3p RBM20 -0.6401165114007 0.000266272092403814 0.805630250198087 0.00223301201387115 MirTarget -0.366544144320892 3.98614404236267e-07 NA NA NA hsa-miR-30c-5p RBM3 -0.432111642767632 0.000159764714931007 1.00558144966015 2.62968112977202e-21 miRNAWalker2_validate -0.167625150828738 0.000396962685675559 NA NA NA hsa-miR-29c-3p RBM33 -1.4367517608807 1.61767774905781e-21 0.427922714212897 1.39440515934481e-10 mirMAP -0.102805173509446 6.23748842935776e-07 NA NA NA hsa-miR-20a-5p RBM43 0.854326758727003 5.04256669663285e-07 -0.466315768538577 0.00138975704061247 mirMAP -0.16769049292253 4.78652474282639e-05 NA NA NA hsa-miR-181a-5p RBM47 0.250113435902954 0.0551933249319293 -0.580007397723855 2.64624683422134e-07 miRNATAP -0.148412051450655 0.000506582508146623 NA NA NA hsa-miR-20a-5p RBM7 0.854326758727003 5.04256669663285e-07 -0.951426616863678 1.80594560797444e-23 mirMAP -0.119535189549173 2.42476541079713e-05 NA NA NA hsa-miR-194-5p RBMS2 -0.292530160992458 0.0996141384876663 -0.129510952127394 0.306339228966227 mirMAP -0.335507596793093 1.30010911381622e-24 NA NA NA hsa-miR-192-5p RBMS3 -0.50188499512787 0.00344713341196035 -1.89502188938102 2.39783861807597e-18 MirTarget -0.283492807663954 8.66770286802988e-06 NA NA NA hsa-miR-19b-3p RBMS3 0.601279551368824 0.00016685097085251 -1.89502188938102 2.39783861807597e-18 MirTarget;mirMAP -0.31606058913024 3.6119142316775e-06 NA NA NA hsa-miR-132-3p RC3H1 0.323796239695997 0.00272093067935091 -0.22445079327746 0.00102447817574616 mirMAP -0.15669131724548 2.97685886024827e-07 NA NA NA hsa-miR-30b-5p RC3H2 -0.54056186708617 2.44688760798341e-05 -0.343082610841661 0.00568417058525379 mirMAP -0.167258322038331 0.000365614468111899 NA NA NA hsa-miR-192-5p RCC2 -0.50188499512787 0.00344713341196035 0.694107774930846 9.98545852945955e-11 miRNAWalker2_validate -0.255103081716065 1.39339507760653e-17 NA NA NA hsa-miR-29c-3p RCC2 -1.4367517608807 1.61767774905781e-21 0.694107774930846 9.98545852945955e-11 MirTarget;miRNATAP -0.277300364610234 1.25776863204485e-17 23442884 MiR 29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2; RCC2 and PPIC were actually upregulated in gastric carcinoma tissues and therefore both were identified as possible targets of miR-29c in gastric carcinoma; We found that RCC2-knockdown decreased both cell viability and BrdU incorporation without any increase of caspase activity while PPIC-knockdown did not indicating that downregulation of RCC2 may be at least partly responsible for the growth suppression by miR-29c; Our findings indicate that miR-29c may have tumor-suppressive functions in gastric carcinoma cells and that its decreased expression may confer a growth advantage on tumor cells via aberrant expression of RCC2 gastric cancer hsa-miR-455-3p RCC2 -1.3998033821095 5.72010709806871e-17 0.694107774930846 9.98545852945955e-11 PITA;miRNATAP -0.10571841691905 0.000566334546538703 NA NA NA hsa-miR-34a-5p RCN1 1.03694231790865 5.74864019540594e-14 -0.291952116719679 0.0727379862149077 miRNAWalker2_validate -0.19978741437577 0.000332964533483244 NA NA NA hsa-miR-455-3p RCN1 -1.3998033821095 5.72010709806871e-17 -0.291952116719679 0.0727379862149077 MirTarget -0.178783626612083 8.26804875406262e-05 NA NA NA hsa-miR-99a-5p RCN2 -1.51481656384839 3.93230057259529e-14 0.702225807365378 7.57876878361327e-13 miRNAWalker2_validate -0.137155586173962 4.02979058443988e-09 NA NA NA hsa-miR-505-5p RCOR3 -0.768282569967001 1.14662846595407e-05 0.682612110290905 2.57158341609511e-13 MirTarget -0.100931812690817 0.000126832478731039 NA NA NA hsa-miR-21-5p RDH11 1.51084295924322 1.54551622173259e-34 -0.412846891947739 0.000434475737209474 miRNAWalker2_validate -0.242728961766966 9.83085113436111e-09 NA NA NA hsa-miR-15a-5p RDH13 0.349521211668244 0.000770735998804736 0.306351353841714 0.0553717301563321 MirTarget -0.211085185817132 0.00505565224881986 NA NA NA hsa-miR-132-3p RDX 0.323796239695997 0.00272093067935091 -0.539334145223494 1.81058771607047e-06 miRNATAP -0.106950677215177 0.0390934770177649 NA NA NA hsa-miR-21-5p RECK 1.51084295924322 1.54551622173259e-34 -0.815315461427365 1.96892620421425e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.243949385419305 0.000503969331428142 25720799;19730150;20480266;22642976;18794849 We verified that HMGB1-induced expression of miR-21 in HCC provides a posttranscriptional repression of the matrix metalloproteinase MMP inhibitors RECK and TIMP3 which are known to impact HCC progression and metastases; Finally we found that inhibition of miR-21 in murine HMGB1-overexpressing HCC xenografts led to reduced tumor MMP activity through released repression of the miR-21 targets RECK and TIMP3 which ultimately impeded tumor progression;Protein levels of tumor suppressor targets of the miRNAs were increased by antisense to miR-21 PTEN and RECK and miR-221 p27;Furthermore we identified that RECK reversion-inducing-cysteine-rich protein with kazal motifs a tumor suppressor gene was a direct target of miR-21; Our results suggest that miR-21 expression has a key role in regulating cellular processes in osteosarcoma likely through regulating RECK and may serve as a therapeutic target;miR 21 may acts as an oncomir by targeting RECK a matrix metalloproteinase regulator in prostate cancer; The micro RNA miRNA mir-21 has been shown to regulate invasiveness in cancer through translational repression of the Metaloproteinase MMP inhibitor RECK; Our aim is to investigate the levels of expression of RECK and miR-21 in PCa comparing with classical prognostic factors and disease outcome and also test if RECK is a target of miR-21 in in vitro study using PCa cell line; To determine if RECK is a target of miR-21 in prostate cancer we performed an in vitro assay with PCa cell line DU-145 transfected with pre-miR-21 and anti-miR-21; To determine miR-21 and RECK expression levels in PCa samples we performed quantitative real-time polymerase chain reaction qRT-PCR; From men who presented the second profile miR-21 overexpression and RECK underexpression 91.7% were staged pT3; Our results demonstrate RECK as a target of miR-21; We believe that miR-21 may be important in PCa progression through its regulation of RECK a known regulator of tumor cell invasion;Finally we showed that RECK a known tumor suppressor in gastric cancer is a bona fide target of miR-21; Taken together miR-21 may be important in the initiation and progression of gastric cancers as an oncomiR likely through regulating RECK; Our findings suggest a potential regulatory pathway in which H pylori infection upregulates expression of miR-21 which in turn downregulates RECK and then leads to the development of gastric cancer metastasis;progression;;;staging;progression;progression liver cancer;pancreatic cancer;sarcoma;prostate cancer;gastric cancer hsa-miR-192-5p RECQL -0.50188499512787 0.00344713341196035 0.461343766657584 8.30631534771756e-05 miRNAWalker2_validate -0.125629153287564 0.000160430200995184 NA NA NA hsa-miR-15a-5p REEP1 0.349521211668244 0.000770735998804736 -1.19516663577168 0.000201705359472497 MirTarget -0.394564947604182 0.00972546853574969 NA NA NA hsa-miR-19b-3p REEP3 0.601279551368824 0.00016685097085251 -0.539596553642068 2.34780145658624e-10 MirTarget;miRNATAP -0.120072583624896 4.28932394574434e-06 NA NA NA hsa-miR-20a-5p REEP3 0.854326758727003 5.04256669663285e-07 -0.539596553642068 2.34780145658624e-10 MirTarget;miRNATAP -0.123952193150281 3.34411039094693e-07 NA NA NA hsa-miR-21-5p REEP5 1.51084295924322 1.54551622173259e-34 -0.41097136505496 2.30189092122078e-06 mirMAP -0.103494196589679 0.00118513348610856 NA NA NA hsa-miR-20a-5p RELL1 0.854326758727003 5.04256669663285e-07 -0.141810188353169 0.221641911979925 MirTarget -0.105618408555217 0.0012477323792959 NA NA NA hsa-miR-192-3p RELT -0.6401165114007 0.000266272092403814 0.230690652493246 0.126823225950896 mirMAP -0.339601388075814 2.6745036790353e-17 NA NA NA hsa-miR-146b-5p REPS2 0.419719546795449 0.0457375823220155 -1.10574349357584 1.56638093233755e-10 miRanda -0.14666711389689 0.00032718824553352 NA NA NA hsa-miR-181a-5p REPS2 0.250113435902954 0.0551933249319293 -1.10574349357584 1.56638093233755e-10 MirTarget -0.316387582623717 1.45890250074242e-06 NA NA NA hsa-miR-181b-5p REPS2 0.488256489401108 0.00105321129419701 -1.10574349357584 1.56638093233755e-10 MirTarget -0.342323944020876 1.55453234963799e-09 NA NA NA hsa-miR-20a-5p REPS2 0.854326758727003 5.04256669663285e-07 -1.10574349357584 1.56638093233755e-10 miRNATAP -0.304202385643636 6.00758972605193e-10 NA NA NA hsa-miR-20b-5p REPS2 0.457668023910379 0.0285865211936156 -1.10574349357584 1.56638093233755e-10 miRNATAP -0.132182584614918 0.00128795076721286 NA NA NA hsa-miR-194-5p RERE -0.292530160992458 0.0996141384876663 0.0525248059482717 0.589424792988577 miRNATAP -0.102297036633167 0.000112798135260221 NA NA NA hsa-miR-20a-5p REST 0.854326758727003 5.04256669663285e-07 -1.00246189990012 0.000168942614777061 MirTarget;miRNATAP -0.205623360970824 0.00684826539877944 NA NA NA hsa-miR-21-5p REST 1.51084295924322 1.54551622173259e-34 -1.00246189990012 0.000168942614777061 miRNAWalker2_validate;miRTarBase;mirMAP -0.485307393654179 5.49786816225102e-07 NA NA NA hsa-miR-15a-5p RET 0.349521211668244 0.000770735998804736 -3.78013089933044 3.56433418082504e-23 MirTarget;miRNATAP -0.67246563912023 0.00038554462318188 NA NA NA hsa-miR-34a-5p RET 1.03694231790865 5.74864019540594e-14 -3.78013089933044 3.56433418082504e-23 MirTarget -0.872637434187161 1.3049522677183e-10 NA NA NA hsa-miR-21-5p REV1 1.51084295924322 1.54551622173259e-34 -0.0941519895887022 0.175117002553565 miRNAWalker2_validate -0.135012076309716 5.30171003159604e-08 NA NA NA hsa-miR-20a-5p REV3L 0.854326758727003 5.04256669663285e-07 -0.483702621543161 0.000164111273212257 miRNATAP -0.10999882645294 0.00259498316118163 NA NA NA hsa-miR-21-5p REV3L 1.51084295924322 1.54551622173259e-34 -0.483702621543161 0.000164111273212257 miRNAWalker2_validate -0.292308331723035 2.44981895454986e-10 NA NA NA hsa-miR-221-3p REV3L 1.12244756358612 3.48370308238012e-13 -0.483702621543161 0.000164111273212257 miRNATAP -0.141261854229422 0.00035348728523936 NA NA NA hsa-miR-222-3p REV3L 1.08574156066353 1.76407192348131e-11 -0.483702621543161 0.000164111273212257 miRNATAP -0.10308384332615 0.0067651627483365 NA NA NA hsa-miR-192-5p RFWD3 -0.50188499512787 0.00344713341196035 0.435632342748586 1.3132101658858e-06 miRNAWalker2_validate -0.111367387435235 1.32685837373949e-05 NA NA NA hsa-miR-146b-5p RFX2 0.419719546795449 0.0457375823220155 -0.676653033188787 0.000273610904741633 miRanda -0.11129019133745 0.0103076286115757 NA NA NA hsa-miR-29c-3p RFX7 -1.4367517608807 1.61767774905781e-21 0.210567553364805 0.028644092780508 MirTarget -0.106688563141715 0.000291772734389885 NA NA NA hsa-miR-17-3p RGAG4 0.410352776142368 0.00422200500748636 -1.76466483030876 1.17761300186306e-14 miRNATAP -0.339781551844517 2.0941311096656e-05 NA NA NA hsa-miR-19b-3p RGL1 0.601279551368824 0.00016685097085251 -0.973948619416663 1.26483337600823e-11 MirTarget;miRNATAP -0.346750056186831 1.14800358840507e-15 NA NA NA hsa-miR-20a-5p RGL1 0.854326758727003 5.04256669663285e-07 -0.973948619416663 1.26483337600823e-11 MirTarget;miRNATAP -0.370894710581805 1.31087181871098e-20 NA NA NA hsa-miR-455-5p RGL1 -0.270546034117157 0.0581320703577731 -0.973948619416663 1.26483337600823e-11 miRanda -0.237023712666923 2.14420252804157e-06 NA NA NA hsa-miR-27b-3p RGL2 -0.823491817819754 9.20935302746823e-14 0.662505393800065 9.47215024955331e-11 miRNATAP -0.120382501135317 0.00747149937726321 NA NA NA hsa-miR-148a-3p RGMA -0.748702855596996 3.93313343865641e-07 1.61034636670118 7.04556214896046e-13 miRNATAP -0.400326990300846 7.66740132539719e-08 NA NA NA hsa-miR-455-5p RGS4 -0.270546034117157 0.0581320703577731 -1.45690815898734 2.10409887435192e-06 PITA;miRanda -0.345862139770033 0.00113332396078148 NA NA NA hsa-miR-146a-5p RGS5 -0.742958238440575 0.000765983177482633 1.13782777301258 6.35983871996091e-09 MirTarget -0.134828215954823 0.00205875449753573 NA NA NA hsa-miR-146b-5p RGS5 0.419719546795449 0.0457375823220155 1.13782777301258 6.35983871996091e-09 MirTarget;miRanda -0.142196925595326 0.00208426837771429 NA NA NA hsa-miR-181a-5p RHBDD1 0.250113435902954 0.0551933249319293 -0.179853319819061 0.0490903635566751 mirMAP -0.100332364813392 0.00332306052283161 NA NA NA hsa-miR-455-3p RHBDF1 -1.3998033821095 5.72010709806871e-17 0.692593164605128 1.65730911234519e-06 MirTarget;PITA;miRNATAP -0.209381271891566 2.41359293754552e-07 NA NA NA hsa-miR-181b-5p RHBDL3 0.488256489401108 0.00105321129419701 1.4613952794321 0.000215161782120482 mirMAP -0.384951896769435 0.00300269176000599 NA NA NA hsa-miR-192-5p RHBDL3 -0.50188499512787 0.00344713341196035 1.4613952794321 0.000215161782120482 mirMAP -0.259658295704621 0.0214388955940487 NA NA NA hsa-miR-30c-5p RHEBL1 -0.432111642767632 0.000159764714931007 1.4822269050808 5.27910865253226e-17 miRNATAP -0.159947129964431 0.0416838529303333 NA NA NA hsa-miR-19b-3p RHOB 0.601279551368824 0.00016685097085251 -1.7358770639627 5.43143135520556e-23 MirTarget;miRNATAP -0.252457126016046 6.53608860264224e-06 NA NA NA hsa-miR-21-5p RHOB 1.51084295924322 1.54551622173259e-34 -1.7358770639627 5.43143135520556e-23 miRNAWalker2_validate;miRTarBase;miRNATAP -0.561330691774606 7.06300169113094e-18 21872591;25861727 miR 21 targets the tumor suppressor RhoB and regulates proliferation invasion and apoptosis in colorectal cancer cells; Here we show that expression of miR-21 in HEK293 and several colorectal cancer cells was found inversely correlated with ras homolog gene family member B RhoB expression; miR-21 expression significantly suppressed RhoB 3' UTR luciferase-reporter activity but the inhibitory effect was lost when the putative target sites were mutated; Exogenous miR-21 over-expression mimicked the effect of RhoB knockdown in promoting proliferation and invasion and inhibiting apoptosis whereas anti-miR-21 or RhoB expression yielded opposite effects in colorectal cancer cells; These results suggest that miR-21 is a regulator of RhoB expression and RhoB could be a useful target in exploring the potential therapeutic benefits of miR-21 mediated tumor cell behaviors in colorectal cancer;Here we demonstrate that intravenously-administered chlorotoxin CTX-coupled targeted stable nucleic acid lipid particle SNALP-formulated anti-miR-21 oligonucleotides accumulate preferentially within brain tumors and promote efficient miR-21 silencing which results in increased mRNA and protein levels of its target RhoB while showing no signs of systemic immunogenicity ; colorectal cancer;glioblastoma hsa-miR-224-3p RHOB 1.40770116795301 1.31426607144612e-08 -1.7358770639627 5.43143135520556e-23 mirMAP -0.113116500008515 0.00184583486508887 NA NA NA hsa-miR-182-5p RHOBTB1 1.96601340710222 4.39326175603633e-09 -0.137296947172223 0.622702437970867 miRNATAP -0.105689644816704 0.00780832860971299 NA NA NA hsa-miR-27b-3p RHOBTB1 -0.823491817819754 9.20935302746823e-14 -0.137296947172223 0.622702437970867 miRNATAP -0.457174181238675 0.000131385941935215 NA NA NA hsa-miR-455-3p RHOBTB2 -1.3998033821095 5.72010709806871e-17 0.696652833288109 7.13271675283038e-07 mirMAP -0.212345805957675 7.0154194550556e-08 NA NA NA hsa-miR-20a-5p RHOC 0.854326758727003 5.04256669663285e-07 0.547331579271749 6.06551674902971e-07 MirTarget;miRNATAP -0.123066154140941 8.29242129116106e-05 NA NA NA hsa-miR-455-3p RHOC -1.3998033821095 5.72010709806871e-17 0.547331579271749 6.06551674902971e-07 miRNAWalker2_validate -0.140800553422948 5.1007124843477e-06 NA NA NA hsa-miR-19b-3p RHOJ 0.601279551368824 0.00016685097085251 0.0847418168433807 0.564149076857352 mirMAP -0.127771734839086 0.00409371497766443 NA NA NA hsa-miR-132-3p RHOU 0.323796239695997 0.00272093067935091 -0.134435858694506 0.304373037130327 MirTarget -0.31541095779824 6.79649402155035e-08 NA NA NA hsa-miR-15a-5p RHPN2 0.349521211668244 0.000770735998804736 -0.401986373693008 0.00594253107367877 MirTarget -0.367686886414011 6.63860179011795e-08 NA NA NA hsa-miR-146b-5p RIC8B 0.419719546795449 0.0457375823220155 0.0633242659452633 0.517717652069902 PITA;miRanda -0.12023967659249 6.97589206594441e-08 NA NA NA hsa-miR-192-5p RIC8B -0.50188499512787 0.00344713341196035 0.0633242659452633 0.517717652069902 miRNAWalker2_validate;MirTarget -0.115537585517966 2.57512233984628e-05 NA NA NA hsa-miR-192-5p RIMKLA -0.50188499512787 0.00344713341196035 -0.0467149849825641 0.857277532379306 miRNAWalker2_validate -0.378132261073007 1.96123417592123e-07 NA NA NA hsa-miR-19b-3p RIMKLA 0.601279551368824 0.00016685097085251 -0.0467149849825641 0.857277532379306 miRNATAP -0.288925881864228 0.000232900270619565 NA NA NA hsa-miR-15a-5p RIMKLB 0.349521211668244 0.000770735998804736 -0.389370791281358 0.0331706644700425 MirTarget;miRNATAP -0.215028682253053 0.0126535032171187 NA NA NA hsa-miR-192-3p RIMKLB -0.6401165114007 0.000266272092403814 -0.389370791281358 0.0331706644700425 MirTarget -0.400496658194967 2.18141585528805e-16 NA NA NA hsa-miR-455-5p RIMKLB -0.270546034117157 0.0581320703577731 -0.389370791281358 0.0331706644700425 miRanda -0.279071187122276 7.14095244712296e-06 NA NA NA hsa-miR-455-3p RIMS3 -1.3998033821095 5.72010709806871e-17 0.886459280872801 5.2547274126985e-06 miRNATAP -0.357211724684948 3.76173605304268e-11 NA NA NA hsa-miR-505-5p RIMS3 -0.768282569967001 1.14662846595407e-05 0.886459280872801 5.2547274126985e-06 mirMAP -0.178797028034004 0.000965003128919277 NA NA NA hsa-miR-19b-3p RIN2 0.601279551368824 0.00016685097085251 -0.596393567207654 1.690638710553e-05 miRNATAP -0.156556185608967 0.00021444785532711 NA NA NA hsa-miR-455-5p RIN2 -0.270546034117157 0.0581320703577731 -0.596393567207654 1.690638710553e-05 miRanda;miRNATAP -0.113992750861224 0.0173379225133496 NA NA NA hsa-miR-29c-3p RIT1 -1.4367517608807 1.61767774905781e-21 0.595574837085402 2.76047144897777e-12 MirTarget -0.163125112241394 5.97868172632589e-10 NA NA NA hsa-miR-181a-5p RLF 0.250113435902954 0.0551933249319293 -0.463388101192929 2.9649077154719e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.119864722044111 0.00137624646994008 NA NA NA hsa-miR-181b-5p RLF 0.488256489401108 0.00105321129419701 -0.463388101192929 2.9649077154719e-06 MirTarget;miRNATAP -0.103563311867167 0.00148433212129687 NA NA NA hsa-miR-20a-5p RLIM 0.854326758727003 5.04256669663285e-07 -0.238618585783741 0.00274903628212624 MirTarget -0.107041090463252 1.64746466200643e-06 NA NA NA hsa-miR-181a-5p RMND5A 0.250113435902954 0.0551933249319293 -0.492348577397466 7.84892428586817e-07 mirMAP;miRNATAP -0.21013357976387 1.67158541845667e-08 NA NA NA hsa-miR-181b-5p RMND5A 0.488256489401108 0.00105321129419701 -0.492348577397466 7.84892428586817e-07 mirMAP;miRNATAP -0.222093130430039 4.46243719964206e-12 NA NA NA hsa-miR-21-5p RMND5A 1.51084295924322 1.54551622173259e-34 -0.492348577397466 7.84892428586817e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.403003232389479 2.03513171913892e-32 NA NA NA hsa-miR-20a-5p RNASEL 0.854326758727003 5.04256669663285e-07 -0.297651918005738 0.0884553326716658 MirTarget -0.384301464046521 9.44852630084857e-16 NA NA NA hsa-miR-21-5p RNF103 1.51084295924322 1.54551622173259e-34 -0.254183630226668 0.00489792672661882 MirTarget -0.159966535927483 9.34956974467895e-07 NA NA NA hsa-miR-19b-3p RNF11 0.601279551368824 0.00016685097085251 -0.638411154558487 5.72201685892189e-13 miRNAWalker2_validate;MirTarget;miRNATAP -0.266248859700488 1.75374439717132e-24 NA NA NA hsa-miR-21-5p RNF11 1.51084295924322 1.54551622173259e-34 -0.638411154558487 5.72201685892189e-13 miRNAWalker2_validate -0.255585765765577 1.58574927655847e-15 NA NA NA hsa-miR-455-5p RNF11 -0.270546034117157 0.0581320703577731 -0.638411154558487 5.72201685892189e-13 miRanda -0.112881396594262 0.000271184667405862 NA NA NA hsa-miR-15a-5p RNF111 0.349521211668244 0.000770735998804736 -0.210320255430396 0.0161550339003716 miRNATAP -0.145930053942034 0.000367745274193019 NA NA NA hsa-miR-17-3p RNF111 0.410352776142368 0.00422200500748636 -0.210320255430396 0.0161550339003716 MirTarget;miRNATAP -0.11149592285104 0.000159762700634299 NA NA NA hsa-miR-21-5p RNF111 1.51084295924322 1.54551622173259e-34 -0.210320255430396 0.0161550339003716 miRNATAP -0.135087044530108 1.94177510649676e-05 NA NA NA hsa-miR-132-3p RNF128 0.323796239695997 0.00272093067935091 -0.731583017031184 9.18291340209668e-08 miRNAWalker2_validate -0.322542345498206 2.20980088099921e-07 NA NA NA hsa-miR-20a-5p RNF128 0.854326758727003 5.04256669663285e-07 -0.731583017031184 9.18291340209668e-08 MirTarget;miRNATAP -0.18441988180697 2.25872693408926e-06 NA NA NA hsa-miR-20b-5p RNF128 0.457668023910379 0.0285865211936156 -0.731583017031184 9.18291340209668e-08 MirTarget;miRNATAP -0.118377885301176 0.000239162978404214 NA NA NA hsa-miR-455-5p RNF135 -0.270546034117157 0.0581320703577731 -0.878582735436686 6.71556010625788e-06 miRanda -0.212586425863099 0.00160921027092974 NA NA NA hsa-miR-192-3p RNF144A -0.6401165114007 0.000266272092403814 0.810171087466595 2.5048912384854e-06 mirMAP -0.334374740745163 9.45205022154096e-13 NA NA NA hsa-miR-27b-3p RNF144A -0.823491817819754 9.20935302746823e-14 0.810171087466595 2.5048912384854e-06 MirTarget;miRNATAP -0.321043758510163 1.62455799730643e-05 NA NA NA hsa-miR-182-5p RNF144B 1.96601340710222 4.39326175603633e-09 -1.17851543947476 1.84208554875109e-14 miRNATAP -0.109209280952833 1.11460846040821e-06 NA NA NA hsa-miR-146b-5p RNF150 0.419719546795449 0.0457375823220155 -2.1984220413943 5.55555217066012e-13 miRanda -0.165037683091883 0.0235569930756019 NA NA NA hsa-miR-17-3p RNF152 0.410352776142368 0.00422200500748636 -1.99846276106589 3.29375349002461e-27 mirMAP -0.133790150483415 0.0468924511961734 NA NA NA hsa-miR-181a-5p RNF152 0.250113435902954 0.0551933249319293 -1.99846276106589 3.29375349002461e-27 mirMAP -0.210979351845032 0.00443292298581936 NA NA NA hsa-miR-181b-5p RNF152 0.488256489401108 0.00105321129419701 -1.99846276106589 3.29375349002461e-27 mirMAP -0.211845675699934 0.00100162879022217 NA NA NA hsa-miR-19b-3p RNF152 0.601279551368824 0.00016685097085251 -1.99846276106589 3.29375349002461e-27 mirMAP -0.192391852344817 0.00132672101756227 NA NA NA hsa-miR-221-3p RNF152 1.12244756358612 3.48370308238012e-13 -1.99846276106589 3.29375349002461e-27 mirMAP -0.529799845859018 7.66563669791234e-20 NA NA NA hsa-miR-222-3p RNF152 1.08574156066353 1.76407192348131e-11 -1.99846276106589 3.29375349002461e-27 mirMAP -0.430735013271361 2.67974077557404e-14 NA NA NA hsa-miR-224-3p RNF152 1.40770116795301 1.31426607144612e-08 -1.99846276106589 3.29375349002461e-27 mirMAP -0.118813149364996 0.00211221701679897 NA NA NA hsa-miR-652-3p RNF152 0.135945800164278 0.391695970197646 -1.99846276106589 3.29375349002461e-27 miRNAWalker2_validate -0.161339092512712 0.00809180708471896 NA NA NA hsa-miR-132-3p RNF165 0.323796239695997 0.00272093067935091 -3.06109685929762 4.74971186974903e-22 mirMAP -0.482269673832235 0.00144886534530519 NA NA NA hsa-miR-19b-3p RNF165 0.601279551368824 0.00016685097085251 -3.06109685929762 4.74971186974903e-22 mirMAP;miRNATAP -0.229155193868949 0.0243108176060301 NA NA NA hsa-miR-20a-5p RNF165 0.854326758727003 5.04256669663285e-07 -3.06109685929762 4.74971186974903e-22 mirMAP -0.319694617444346 0.000720178924944203 NA NA NA hsa-miR-455-5p RNF19B -0.270546034117157 0.0581320703577731 -0.246215399753756 0.0304045952751044 miRanda -0.166463162948795 1.65360125791634e-05 NA NA NA hsa-miR-27b-3p RNF207 -0.823491817819754 9.20935302746823e-14 0.828705825765608 2.83913644606982e-10 miRNATAP -0.260027058787256 5.74935663313936e-06 NA NA NA hsa-miR-455-5p RNF213 -0.270546034117157 0.0581320703577731 0.881179822961089 8.81910677519113e-15 miRanda -0.177987450286598 8.02368626220879e-06 NA NA NA hsa-miR-182-5p RNF217 1.96601340710222 4.39326175603633e-09 -0.867667786029885 3.07330761625567e-05 mirMAP -0.132865887501484 7.69965161557211e-06 NA NA NA hsa-miR-19b-3p RNF217 0.601279551368824 0.00016685097085251 -0.867667786029885 3.07330761625567e-05 mirMAP -0.269467422063617 2.12092442512244e-05 NA NA NA hsa-miR-224-3p RNF217 1.40770116795301 1.31426607144612e-08 -0.867667786029885 3.07330761625567e-05 mirMAP -0.109696647849382 0.00763749129727933 NA NA NA hsa-miR-30b-5p RNF217 -0.54056186708617 2.44688760798341e-05 -0.867667786029885 3.07330761625567e-05 mirMAP -0.231157174735168 0.00365807766409212 NA NA NA hsa-miR-27b-3p RNF24 -0.823491817819754 9.20935302746823e-14 1.10714531329534 8.18323484435844e-11 mirMAP -0.409713529474916 3.19620219118214e-08 NA NA NA hsa-miR-148a-3p RNF44 -0.748702855596996 3.93313343865641e-07 0.663587868143992 1.70848468031349e-11 miRNATAP -0.205949484265224 1.81870928982656e-10 NA NA NA hsa-miR-181a-5p RNF6 0.250113435902954 0.0551933249319293 -0.192650958603799 0.0356267381099909 MirTarget;miRNATAP -0.107748311213541 0.00166384817375465 NA NA NA hsa-miR-181b-5p RNF6 0.488256489401108 0.00105321129419701 -0.192650958603799 0.0356267381099909 MirTarget;miRNATAP -0.106449094309103 0.000346893951393536 NA NA NA hsa-miR-30b-5p RNF8 -0.54056186708617 2.44688760798341e-05 0.684299202639712 6.08704098358966e-15 mirMAP -0.107909331521699 0.00161409735271121 NA NA NA hsa-miR-30e-5p RNF8 -0.627815042856657 3.02205690184908e-10 0.684299202639712 6.08704098358966e-15 mirMAP -0.108574451488416 0.0130463092930949 NA NA NA hsa-miR-20a-5p RNH1 0.854326758727003 5.04256669663285e-07 0.0423956504637601 0.606057902948997 miRNATAP -0.137925378303679 1.32340045810629e-09 NA NA NA hsa-miR-148a-3p ROBO1 -0.748702855596996 3.93313343865641e-07 2.32143722202073 1.044638687882e-16 MirTarget;miRNATAP -0.420616800754574 8.25510016639746e-06 NA NA NA hsa-miR-29c-3p ROBO1 -1.4367517608807 1.61767774905781e-21 2.32143722202073 1.044638687882e-16 MirTarget -0.612385165654035 2.35267850910656e-12 NA NA NA hsa-miR-148a-3p ROBO2 -0.748702855596996 3.93313343865641e-07 -1.20081293982521 0.00234813022306189 miRNATAP -0.266203176462404 0.0402513644855282 NA NA NA hsa-miR-146b-5p ROBO4 0.419719546795449 0.0457375823220155 -0.113841461867362 0.426767073353492 miRanda -0.119343657894217 0.0003008276566571 NA NA NA hsa-miR-15a-5p ROR1 0.349521211668244 0.000770735998804736 -0.491754583860676 0.154312136980948 MirTarget;miRNATAP -0.34557427122255 0.0339092304628976 NA NA NA hsa-miR-19b-3p ROR1 0.601279551368824 0.00016685097085251 -0.491754583860676 0.154312136980948 miRNAWalker2_validate;MirTarget -0.387507848816132 0.000207855405644965 NA NA NA hsa-miR-224-3p ROR1 1.40770116795301 1.31426607144612e-08 -0.491754583860676 0.154312136980948 mirMAP -0.14310128968974 0.0345755463028793 NA NA NA hsa-miR-27b-3p ROR1 -0.823491817819754 9.20935302746823e-14 -0.491754583860676 0.154312136980948 MirTarget;miRNATAP -0.469646389829807 0.00156411878262893 26576539 Bioinformatic prediction luciferase reporter assay quantitative real-time PCR qRT-PCR and western blotting were used to reveal the regulatory relationship between miR-27b-3p and ROR1; The expression patterns of miR-27b-3p and ROR1 in human gastric cancer GC specimens and cell lines were determined by microRNA RT-PCR and western blotting; miR-27b-3p suppressed ROR1 expression by binding to the 3'UTR of ROR1 mRNA in GC cells; miR-27b-3p was significantly downregulated and reversely correlated with ROR1 protein levels in clinical samples; Analysis of the clinicopathological significance showed that miR-27b-3p and ROR1 were closely correlated with GC characteristics; These results show that miR-27b-3p suppresses ROR1 expression through the binding site in the 3'UTR inhibiting the cell proliferation; These findings indicate that miR-27b-3p exerts tumor-suppressive effects in GC through the suppression of oncogene ROR1 expression and suggest a therapeutic application of miR-27b-3p in GC gastric cancer hsa-miR-132-3p RORA 0.323796239695997 0.00272093067935091 -1.18591701647076 1.08163415927424e-11 mirMAP -0.545118806656125 6.10880039358204e-12 NA NA NA hsa-miR-15a-5p RORA 0.349521211668244 0.000770735998804736 -1.18591701647076 1.08163415927424e-11 MirTarget;miRNATAP -0.178586570909124 0.034497601901814 NA NA NA hsa-miR-17-3p RORA 0.410352776142368 0.00422200500748636 -1.18591701647076 1.08163415927424e-11 miRNATAP -0.324956222992838 6.27087649088908e-08 NA NA NA hsa-miR-181a-5p RORA 0.250113435902954 0.0551933249319293 -1.18591701647076 1.08163415927424e-11 MirTarget;miRNATAP -0.441988877512522 1.70143680947594e-11 NA NA NA hsa-miR-181b-5p RORA 0.488256489401108 0.00105321129419701 -1.18591701647076 1.08163415927424e-11 MirTarget;miRNATAP -0.491703841118883 1.83302263910487e-18 NA NA NA hsa-miR-19b-3p RORA 0.601279551368824 0.00016685097085251 -1.18591701647076 1.08163415927424e-11 MirTarget;miRNATAP -0.209495261129072 0.000108577296604644 NA NA NA hsa-miR-20a-5p RORA 0.854326758727003 5.04256669663285e-07 -1.18591701647076 1.08163415927424e-11 MirTarget;miRNATAP -0.274250331473419 4.20968585910911e-08 NA NA NA hsa-miR-20b-5p RORA 0.457668023910379 0.0285865211936156 -1.18591701647076 1.08163415927424e-11 MirTarget;miRNATAP -0.166557727231825 5.8895142153919e-05 NA NA NA hsa-miR-409-3p RORA -0.499649792570937 0.0526751181520117 -1.18591701647076 1.08163415927424e-11 mirMAP -0.111600904684558 0.000928220637062844 NA NA NA hsa-miR-21-5p RP2 1.51084295924322 1.54551622173259e-34 -0.819209747170963 6.4575408341589e-09 miRNAWalker2_validate;miRNATAP -0.242080603331582 3.16543614744208e-06 NA NA NA hsa-miR-181a-5p RPAP2 0.250113435902954 0.0551933249319293 0.13738462327106 0.0752970261527869 MirTarget -0.114488943330826 6.58611531022851e-05 NA NA NA hsa-miR-181b-5p RPAP2 0.488256489401108 0.00105321129419701 0.13738462327106 0.0752970261527869 MirTarget -0.100204176075283 5.92381497576948e-05 NA NA NA hsa-miR-455-5p RPGR -0.270546034117157 0.0581320703577731 0.0985563688186515 0.478273275455989 miRanda -0.103149271347146 0.0300549071651442 NA NA NA hsa-miR-17-3p RPGRIP1L 0.410352776142368 0.00422200500748636 0.672861725371994 2.95668883160042e-07 miRNATAP -0.128307957046456 0.00450131302480491 NA NA NA hsa-miR-192-5p RPGRIP1L -0.50188499512787 0.00344713341196035 0.672861725371994 2.95668883160042e-07 miRNAWalker2_validate -0.29949373136012 1.76626747021087e-16 NA NA NA hsa-miR-27b-3p RPGRIP1L -0.823491817819754 9.20935302746823e-14 0.672861725371994 2.95668883160042e-07 MirTarget;miRNATAP -0.181986506407573 0.00145788753392262 NA NA NA hsa-miR-455-5p RPGRIP1L -0.270546034117157 0.0581320703577731 0.672861725371994 2.95668883160042e-07 miRanda -0.16324823196796 0.000319880174293518 NA NA NA hsa-miR-15a-5p RPH3AL 0.349521211668244 0.000770735998804736 -0.983084479734232 2.30167276323197e-13 MirTarget -0.200477018492297 0.00202524681849763 NA NA NA hsa-miR-30e-5p RPIA -0.627815042856657 3.02205690184908e-10 0.596191356011587 2.32659407207361e-14 miRNAWalker2_validate -0.19841629302567 2.33990487733816e-07 NA NA NA hsa-miR-30c-5p RPL27A -0.432111642767632 0.000159764714931007 0.234707534420435 0.0687896119858048 miRNAWalker2_validate -0.133318913227691 0.0152322629078287 NA NA NA hsa-miR-30c-5p RPL32 -0.432111642767632 0.000159764714931007 0.261487100591939 0.0411802906060375 miRNAWalker2_validate -0.166428159508611 0.00224564827402813 NA NA NA hsa-miR-99a-5p RPL36A -1.51481656384839 3.93230057259529e-14 1.6674642742218 9.30020984679361e-14 miRNAWalker2_validate -0.330308384044627 6.37175649786414e-10 NA NA NA hsa-miR-99a-5p RPL37A -1.51481656384839 3.93230057259529e-14 0.326434942142685 0.0178610827022925 miRNAWalker2_validate -0.137847238511366 1.96931545866735e-05 NA NA NA hsa-miR-30e-5p RPLP0 -0.627815042856657 3.02205690184908e-10 0.4870310721327 5.29851288044626e-05 miRNAWalker2_validate -0.297165812650813 2.92788023345277e-07 NA NA NA hsa-miR-505-5p RPLP2 -0.768282569967001 1.14662846595407e-05 0.479196330931666 0.00039433043165723 miRNAWalker2_validate -0.152246820941241 4.43624288432952e-05 NA NA NA hsa-miR-27b-3p RPN2 -0.823491817819754 9.20935302746823e-14 0.474714258889196 1.36911430658968e-11 miRNATAP -0.154968262295887 3.7245765251133e-07 NA NA NA hsa-miR-30e-5p RPP30 -0.627815042856657 3.02205690184908e-10 0.378237424018944 8.16438363363359e-07 mirMAP -0.141327454745421 0.000144501136145506 NA NA NA hsa-miR-15a-5p RPRD1B 0.349521211668244 0.000770735998804736 -0.539926954610961 9.40494592976686e-08 MirTarget -0.131853958140817 0.00627960305499575 NA NA NA hsa-miR-99b-5p RPS10 -0.204769880349524 0.240836989110525 0.628534632895926 3.61831272981553e-06 miRNAWalker2_validate -0.118474375320851 0.00197493738310957 NA NA NA hsa-miR-30c-5p RPS12 -0.432111642767632 0.000159764714931007 0.243980870752836 0.0730841529982439 miRNAWalker2_validate -0.154895476527633 0.00751824381151065 NA NA NA hsa-miR-99a-5p RPS15 -1.51481656384839 3.93230057259529e-14 0.306561366983481 0.0175521717825054 miRNAWalker2_validate -0.102143703911737 0.000768234212382054 NA NA NA hsa-miR-30c-5p RPS27A -0.432111642767632 0.000159764714931007 0.317404543049338 0.006769012872385 miRNAWalker2_validate -0.117131976788904 0.0192292132325846 NA NA NA hsa-miR-30c-5p RPS3 -0.432111642767632 0.000159764714931007 0.394140079752983 0.000834768525344542 miRNAWalker2_validate -0.153482509633064 0.00230632824215521 NA NA NA hsa-miR-99a-5p RPS6 -1.51481656384839 3.93230057259529e-14 0.185885010447493 0.120916808338817 miRNAWalker2_validate -0.141086052819295 4.22214050226356e-07 NA NA NA hsa-miR-20a-5p RPS6KA1 0.854326758727003 5.04256669663285e-07 -0.0193982843076919 0.895272926505225 miRNATAP -0.140420093444226 0.000724052018701145 NA NA NA hsa-miR-192-3p RPS6KA2 -0.6401165114007 0.000266272092403814 -0.429936688183553 0.00940192295734202 mirMAP -0.190995022600123 2.73504188366536e-05 NA NA NA hsa-miR-19b-3p RPS6KA2 0.601279551368824 0.00016685097085251 -0.429936688183553 0.00940192295734202 MirTarget -0.235922153431053 2.30069900396003e-06 NA NA NA hsa-miR-455-3p RPS6KA4 -1.3998033821095 5.72010709806871e-17 0.532916218348247 4.99919889760201e-13 PITA;miRNATAP -0.123389944483937 3.21577157483491e-09 NA NA NA hsa-miR-20a-5p RPS6KA5 0.854326758727003 5.04256669663285e-07 -0.827283685514513 1.58444228442933e-05 MirTarget -0.133604221805227 0.0148516181805604 NA NA NA hsa-miR-181a-5p RPS6KB1 0.250113435902954 0.0551933249319293 0.0405513114293425 0.579068505304799 MirTarget;miRNATAP -0.116671963226395 1.5972465565874e-05 NA NA NA hsa-miR-30e-5p RPS7 -0.627815042856657 3.02205690184908e-10 0.465755681089079 4.25824545301515e-05 miRNAWalker2_validate -0.23864279879007 1.41507766338404e-05 NA NA NA hsa-miR-30e-5p RPS8 -0.627815042856657 3.02205690184908e-10 0.338434745906953 0.00458695720644551 miRNAWalker2_validate -0.17361415874523 0.00263252858782296 NA NA NA hsa-miR-27b-3p RPTOR -0.823491817819754 9.20935302746823e-14 0.681970822272688 1.01116104311691e-17 miRNAWalker2_validate -0.116093691653188 0.001071699641235 NA NA NA hsa-miR-30e-5p RRAD -0.627815042856657 3.02205690184908e-10 -0.433500911663112 0.140544735292824 MirTarget -0.424845015263566 0.00277983782299064 NA NA NA hsa-miR-30c-5p RRM2 -0.432111642767632 0.000159764714931007 3.28040567179396 1.92251546747087e-44 miRNAWalker2_validate -0.448871386564653 5.30128645915653e-05 NA NA NA hsa-miR-30e-5p RRP8 -0.627815042856657 3.02205690184908e-10 -0.115274024128074 0.141596557176717 mirMAP -0.108970396166255 0.00381674056756933 NA NA NA hsa-miR-17-3p RSBN1 0.410352776142368 0.00422200500748636 -0.449018724973878 5.46712303920279e-08 MirTarget -0.113335497002307 6.03999202369434e-05 NA NA NA hsa-miR-21-5p RSBN1 1.51084295924322 1.54551622173259e-34 -0.449018724973878 5.46712303920279e-08 miRNATAP -0.161692680668615 7.78930500169261e-08 NA NA NA hsa-miR-21-5p RSF1 1.51084295924322 1.54551622173259e-34 -0.42651865559777 1.69657930050886e-05 miRNAWalker2_validate -0.223277086683801 4.14888167197538e-10 NA NA NA hsa-miR-181a-5p RSPO2 0.250113435902954 0.0551933249319293 -1.47503442551075 0.000466618278395286 MirTarget;miRNATAP -0.687508613013221 1.36887906462586e-05 NA NA NA hsa-miR-181b-5p RSPO2 0.488256489401108 0.00105321129419701 -1.47503442551075 0.000466618278395286 MirTarget;miRNATAP -0.876393534278742 1.04924147416766e-10 NA NA NA hsa-miR-192-3p RSPO2 -0.6401165114007 0.000266272092403814 -1.47503442551075 0.000466618278395286 MirTarget -0.405318192039028 0.000522808178268647 NA NA NA hsa-miR-15a-5p RSPO3 0.349521211668244 0.000770735998804736 -5.23808210769682 1.96815328553761e-37 MirTarget -0.817271252687934 0.00010677396898025 NA NA NA hsa-miR-19b-3p RSPO3 0.601279551368824 0.00016685097085251 -5.23808210769682 1.96815328553761e-37 MirTarget -0.6549449012121 1.30017039629501e-06 NA NA NA hsa-miR-21-5p RSPRY1 1.51084295924322 1.54551622173259e-34 -0.728312362542739 0.000260269767961343 miRNAWalker2_validate -0.287552771807177 7.92783272600922e-05 NA NA NA hsa-miR-215-5p RTKN2 -0.981544773246509 3.14452272477156e-05 2.57925113894623 4.76198655776531e-18 miRNAWalker2_validate -0.13035497542525 0.0410132408811955 NA NA NA hsa-miR-30e-5p RTKN2 -0.627815042856657 3.02205690184908e-10 2.57925113894623 4.76198655776531e-18 MirTarget -0.502756296981053 0.000798474132926716 NA NA NA hsa-miR-19b-3p RTN1 0.601279551368824 0.00016685097085251 0.0619133442933343 0.777858219400895 miRNATAP -0.169689725943548 0.0108310090216199 NA NA NA hsa-miR-132-3p RTN4 0.323796239695997 0.00272093067935091 -0.737552092106895 3.21720282494762e-12 miRNAWalker2_validate;miRNATAP -0.186079364081366 0.000145775179514667 NA NA NA hsa-miR-21-5p RTN4 1.51084295924322 1.54551622173259e-34 -0.737552092106895 3.21720282494762e-12 miRNAWalker2_validate;miRTarBase -0.270647009690661 2.41797685711415e-12 NA NA NA hsa-miR-34a-5p RTN4RL1 1.03694231790865 5.74864019540594e-14 0.0636442284094436 0.813175055555113 MirTarget;miRNATAP -0.308885836272814 0.000803490840228313 NA NA NA hsa-miR-132-3p RTTN 0.323796239695997 0.00272093067935091 -0.285081241991559 0.00998889216559707 mirMAP -0.172175326421263 0.000581431555766303 NA NA NA hsa-miR-15a-5p RUNDC3B 0.349521211668244 0.000770735998804736 -1.77231643639114 1.974302394488e-11 MirTarget -0.299543639283403 0.0190835169251236 NA NA NA hsa-miR-182-5p RUNDC3B 1.96601340710222 4.39326175603633e-09 -1.77231643639114 1.974302394488e-11 miRNATAP -0.275169215082673 2.41801366035942e-13 NA NA NA hsa-miR-221-3p RUNDC3B 1.12244756358612 3.48370308238012e-13 -1.77231643639114 1.974302394488e-11 miRNAWalker2_validate -0.644731514464414 1.20643721256973e-15 NA NA NA hsa-miR-192-5p RUNX1 -0.50188499512787 0.00344713341196035 -0.00485952026487979 0.975956818735336 mirMAP;miRNATAP -0.313304951639482 1.86103486307586e-12 NA NA NA hsa-miR-455-3p RUNX1 -1.3998033821095 5.72010709806871e-17 -0.00485952026487979 0.975956818735336 PITA -0.151761070302828 0.000751978402905429 NA NA NA hsa-miR-148a-3p RUNX2 -0.748702855596996 3.93313343865641e-07 -0.630390083285145 0.00682374266364812 miRNATAP -0.611751537093558 9.56180468519476e-17 NA NA NA hsa-miR-455-5p RUNX2 -0.270546034117157 0.0581320703577731 -0.630390083285145 0.00682374266364812 miRNATAP -0.259682464795973 0.00114682878707237 27748890 MicroRNA 455 regulates migration and invasion of human hepatocellular carcinoma by targeting Runx2; Moreover we identified that miR-455 inversely regulated Runx2 expression in HCC cells; In this investigation Runx2 was found to be a direct downstream target of miR-455; Evidently alteration in Runx2 expression suppressed the effect of miR-455 on HCC cell migration and invasion; In conclusion our data demonstrated that miR-455 promotes HCC growth by targeting Runx2 and can potentially be regarded as a novel prognostic indicator and valuable therapeutic strategy for HCC cell migration liver cancer hsa-miR-192-3p RUNX3 -0.6401165114007 0.000266272092403814 -1.01114722675633 2.35128238262054e-07 mirMAP -0.305834450652925 1.48341592408617e-08 NA NA NA hsa-miR-192-5p RUNX3 -0.50188499512787 0.00344713341196035 -1.01114722675633 2.35128238262054e-07 mirMAP -0.320525727272112 7.0875310616877e-09 NA NA NA hsa-miR-194-5p RUNX3 -0.292530160992458 0.0996141384876663 -1.01114722675633 2.35128238262054e-07 miRNATAP -0.340317552807197 1.90073801776771e-10 NA NA NA hsa-miR-20a-5p RUNX3 0.854326758727003 5.04256669663285e-07 -1.01114722675633 2.35128238262054e-07 MirTarget -0.142575383323139 0.0112321596436001 27748919 MicroRNA 20a 5p targets RUNX3 to regulate proliferation and migration of human hepatocellular cancer cells; Further studies revealed RUNX3 an important tumor-suppressor as a direct target of miR-20a-5p; Collectively our results support the viewpoint that miR-20-5p has an oncogenic property miR-20a overexpression contributed to HCC cell proliferation and migration through reducing the translation of RUNX3; The data provide a new mechanism of miR-20a regulating RUNX3 in HCC liver cancer hsa-miR-455-3p RUSC1 -1.3998033821095 5.72010709806871e-17 1.30017263372815 2.66258448189137e-27 miRNATAP -0.161823583584555 5.80786715742937e-06 NA NA NA hsa-miR-132-3p S100A1 0.323796239695997 0.00272093067935091 0.926536219891231 0.00102457487341893 miRNAWalker2_validate -0.256365625460829 0.0466624748140034 NA NA NA hsa-miR-181b-5p S1PR1 0.488256489401108 0.00105321129419701 -0.723869489322336 1.31811287279409e-06 MirTarget;miRNATAP -0.125397523699022 0.0112069870070847 NA NA NA hsa-miR-19b-3p S1PR1 0.601279551368824 0.00016685097085251 -0.723869489322336 1.31811287279409e-06 MirTarget;miRNATAP -0.157776972869095 0.000580586503696413 NA NA NA hsa-miR-20a-5p S1PR1 0.854326758727003 5.04256669663285e-07 -0.723869489322336 1.31811287279409e-06 MirTarget;miRNATAP -0.156524671817097 0.000249116225567984 NA NA NA hsa-miR-20b-5p S1PR1 0.457668023910379 0.0285865211936156 -0.723869489322336 1.31811287279409e-06 MirTarget;miRNATAP -0.104563008648894 0.00298629827537191 NA NA NA hsa-miR-146b-5p S1PR3 0.419719546795449 0.0457375823220155 -0.757855433845786 0.000623857511351866 miRanda -0.112489082305208 0.0296068867785853 NA NA NA hsa-miR-34a-5p S1PR3 1.03694231790865 5.74864019540594e-14 -0.757855433845786 0.000623857511351866 MirTarget -0.159662089621442 0.0372209343301902 NA NA NA hsa-miR-21-5p SACM1L 1.51084295924322 1.54551622173259e-34 -0.315204603662408 1.78726511835303e-06 miRNAWalker2_validate -0.236338892627455 3.65128683570502e-25 NA NA NA hsa-miR-148a-3p SACS -0.748702855596996 3.93313343865641e-07 0.236568458255628 0.160647331666559 MirTarget -0.235342582834692 1.67486040913103e-05 NA NA NA hsa-miR-132-3p SALL1 0.323796239695997 0.00272093067935091 -1.08990282256837 2.30542602372023e-08 MirTarget;miRNATAP -0.658164352784995 4.8962679062341e-14 NA NA NA hsa-miR-20b-5p SALL1 0.457668023910379 0.0285865211936156 -1.08990282256837 2.30542602372023e-08 MirTarget;miRNATAP -0.187916108464799 4.28738822389885e-05 NA NA NA hsa-miR-99a-5p SALL2 -1.51481656384839 3.93230057259529e-14 0.257703366669624 0.421215891958776 miRNAWalker2_validate -0.519062088504153 1.74296567594672e-12 NA NA NA hsa-miR-27b-3p SAMD10 -0.823491817819754 9.20935302746823e-14 0.872932422756584 1.87788574518353e-13 miRNATAP -0.226323562537202 1.47791099197243e-05 NA NA NA hsa-miR-20a-5p SAMD12 0.854326758727003 5.04256669663285e-07 -2.38933684023892 1.51021075610838e-11 miRNATAP -0.2858665945878 0.00548109075773982 NA NA NA hsa-miR-192-5p SAMD13 -0.50188499512787 0.00344713341196035 0.350362895121864 0.130706227613663 miRNAWalker2_validate -0.19925279594921 0.00239887256233847 NA NA NA hsa-miR-34a-5p SAMD14 1.03694231790865 5.74864019540594e-14 -0.0144444472362888 0.935408587535856 mirMAP -0.177384683239513 0.00366906622331786 NA NA NA hsa-miR-192-5p SAMD3 -0.50188499512787 0.00344713341196035 -0.65807084601691 0.00282704939406572 miRNAWalker2_validate -0.290151789940621 3.0567412640441e-06 NA NA NA hsa-miR-181a-5p SAMD4A 0.250113435902954 0.0551933249319293 -0.955832382695032 2.80164696716111e-12 mirMAP -0.123248896459794 0.019482313663236 NA NA NA hsa-miR-181b-5p SAMD4A 0.488256489401108 0.00105321129419701 -0.955832382695032 2.80164696716111e-12 mirMAP -0.190362800605672 2.94161710437205e-05 NA NA NA hsa-miR-182-5p SAMD4A 1.96601340710222 4.39326175603633e-09 -0.955832382695032 2.80164696716111e-12 MirTarget;miRNATAP -0.116847860795469 2.9108564228328e-09 NA NA NA hsa-miR-20a-5p SAMD5 0.854326758727003 5.04256669663285e-07 -3.18008032786867 6.30217447905566e-16 mirMAP -0.288636115784874 0.012672633787844 NA NA NA hsa-miR-221-3p SAMD5 1.12244756358612 3.48370308238012e-13 -3.18008032786867 6.30217447905566e-16 mirMAP -0.71879613241747 6.03121839066379e-09 NA NA NA hsa-miR-222-3p SAMD5 1.08574156066353 1.76407192348131e-11 -3.18008032786867 6.30217447905566e-16 mirMAP -0.40983580616276 0.000648248704718989 NA NA NA hsa-miR-194-5p SAMD8 -0.292530160992458 0.0996141384876663 -0.660046840397926 4.02497533644099e-07 MirTarget -0.121952395095751 0.000737989881658955 NA NA NA hsa-miR-19b-3p SAMD8 0.601279551368824 0.00016685097085251 -0.660046840397926 4.02497533644099e-07 miRNAWalker2_validate -0.19560166919306 8.07759953128965e-07 NA NA NA hsa-miR-21-5p SAMD8 1.51084295924322 1.54551622173259e-34 -0.660046840397926 4.02497533644099e-07 mirMAP -0.176847269609028 0.000224590266324053 NA NA NA hsa-miR-30b-5p SAMD8 -0.54056186708617 2.44688760798341e-05 -0.660046840397926 4.02497533644099e-07 MirTarget;miRNATAP -0.173965258296232 0.0004811197828441 NA NA NA hsa-miR-455-5p SAMD8 -0.270546034117157 0.0581320703577731 -0.660046840397926 4.02497533644099e-07 miRanda -0.248475143258538 2.37206693693498e-08 NA NA NA hsa-miR-455-5p SAMD9L -0.270546034117157 0.0581320703577731 -0.255643769918497 0.175280321185002 miRanda -0.454313015822328 4.80353183134041e-13 NA NA NA hsa-miR-181a-5p SAMHD1 0.250113435902954 0.0551933249319293 -0.219855252528804 0.21059107396466 MirTarget -0.153364596389044 0.019967061101647 NA NA NA hsa-miR-181b-5p SAMHD1 0.488256489401108 0.00105321129419701 -0.219855252528804 0.21059107396466 MirTarget -0.150110622113537 0.00877780794121613 NA NA NA hsa-miR-19b-3p SAMHD1 0.601279551368824 0.00016685097085251 -0.219855252528804 0.21059107396466 mirMAP -0.195274185509139 0.000234782244314585 NA NA NA hsa-miR-20a-5p SAMHD1 0.854326758727003 5.04256669663285e-07 -0.219855252528804 0.21059107396466 mirMAP -0.203285313284581 3.88734666921236e-05 NA NA NA hsa-miR-30b-5p SAMHD1 -0.54056186708617 2.44688760798341e-05 -0.219855252528804 0.21059107396466 MirTarget -0.318237703260412 1.34953863304513e-06 NA NA NA hsa-miR-132-3p SAP30L 0.323796239695997 0.00272093067935091 0.39637668016416 2.08535958030862e-06 MirTarget;miRNATAP -0.18379530888699 1.15142635048267e-06 NA NA NA hsa-miR-19b-3p SAR1B 0.601279551368824 0.00016685097085251 -0.602691569549908 4.60715859176311e-06 mirMAP -0.138188147988532 0.00059288718004092 NA NA NA hsa-miR-20a-5p SAR1B 0.854326758727003 5.04256669663285e-07 -0.602691569549908 4.60715859176311e-06 MirTarget;miRNATAP -0.128999389744833 0.000585913519230086 NA NA NA hsa-miR-21-5p SAR1B 1.51084295924322 1.54551622173259e-34 -0.602691569549908 4.60715859176311e-06 mirMAP -0.285426487057633 2.07980510331109e-09 NA NA NA hsa-miR-17-3p SASH1 0.410352776142368 0.00422200500748636 -0.641621637334084 3.36245859697969e-07 MirTarget -0.154033009215297 0.000356252723237895 NA NA NA hsa-miR-20a-5p SASH1 0.854326758727003 5.04256669663285e-07 -0.641621637334084 3.36245859697969e-07 MirTarget;miRNATAP -0.184641895216367 2.23399802113957e-07 NA NA NA hsa-miR-21-5p SASH1 1.51084295924322 1.54551622173259e-34 -0.641621637334084 3.36245859697969e-07 miRNAWalker2_validate;MirTarget -0.229739176617252 5.80981721365785e-07 NA NA NA hsa-miR-455-5p SASH3 -0.270546034117157 0.0581320703577731 -0.565734035431722 0.00284888178066204 miRNATAP -0.226150136767461 0.000499076345637989 NA NA NA hsa-miR-652-3p SAT1 0.135945800164278 0.391695970197646 -0.88727386577601 5.46294149352197e-11 miRNAWalker2_validate -0.123437103697464 0.00378229152616883 NA NA NA hsa-miR-194-5p SATB1 -0.292530160992458 0.0996141384876663 -1.66235785428604 6.97431443036821e-14 miRNATAP -0.134580750428564 0.0327838314495217 NA NA NA hsa-miR-19b-3p SATB1 0.601279551368824 0.00016685097085251 -1.66235785428604 6.97431443036821e-14 miRNATAP -0.172150078172972 0.0134448122903903 NA NA NA hsa-miR-21-5p SATB1 1.51084295924322 1.54551622173259e-34 -1.66235785428604 6.97431443036821e-14 MirTarget;miRNATAP -0.340471853554043 4.20923938471208e-05 27107063 SATB1 is Down regulated in Clear Cell Renal Cell Carcinoma and Correlates with miR 21 5p Overexpression and Poor Prognosis; This study aimed to determine the expression levels of SATB1 as well as miR-21-5p -the post-transcriptional repressor of SATB1 expression- in clear cell renal cell carcinoma ccRCC and to investigate their association with the progression of ccRCC; Immunohistochemistry and quantitative polymerase chain reaction were used to assess the expression of SATB1 protein and mRNA as well as miR-21-5p in tumor and matched normal kidney tissues collected from 56 ccRCC patients; SATB1 mRNA level was down-regulated in ccRCC tissue and inversely correlated with the content of miR-21-5p; Down-regulation of SATB1 mRNA and up-regulation of miR-21-5p were associated with shorter patient survival; Decreased expression of SATB1 in ccRCC may result from over-expressed miR-21-5p worse prognosis;progression;poor survival kidney renal cell cancer hsa-miR-34a-5p SATB1 1.03694231790865 5.74864019540594e-14 -1.66235785428604 6.97431443036821e-14 MirTarget;miRNATAP -0.374029558942121 1.60542096572095e-06 NA NA NA hsa-miR-132-3p SATB2 0.323796239695997 0.00272093067935091 0.52003541011141 0.00118691129677399 miRNATAP -0.214863500882548 0.00323452962851412 NA NA NA hsa-miR-30b-5p SATB2 -0.54056186708617 2.44688760798341e-05 0.52003541011141 0.00118691129677399 mirMAP;miRNATAP -0.271655218788999 7.31273563427712e-06 NA NA NA hsa-miR-30c-5p SBF1 -0.432111642767632 0.000159764714931007 1.06405585545956 5.63932142808997e-20 miRNATAP -0.111409414572655 0.0319794236530338 NA NA NA hsa-miR-19b-3p SBF2 0.601279551368824 0.00016685097085251 -0.144871095265673 0.248374594908118 MirTarget;miRNATAP -0.114274725565293 0.00263141069969797 NA NA NA hsa-miR-34a-5p SBK1 1.03694231790865 5.74864019540594e-14 0.360418639058519 0.140066277820954 miRNATAP -0.26315381419128 0.00167872478717627 NA NA NA hsa-miR-21-5p SBNO1 1.51084295924322 1.54551622173259e-34 -0.665259965543963 0.0143028966764536 mirMAP -0.404488518211087 4.20992560960646e-05 NA NA NA hsa-miR-17-3p SCAMP1 0.410352776142368 0.00422200500748636 -0.135318013191192 0.116531835887602 MirTarget -0.114177974572266 8.41984236995273e-05 NA NA NA hsa-miR-27b-3p SCAMP3 -0.823491817819754 9.20935302746823e-14 1.20056451579604 1.63329457117019e-29 miRNATAP -0.256428735108341 1.31537964944869e-07 NA NA NA hsa-miR-29c-3p SCAMP5 -1.4367517608807 1.61767774905781e-21 1.15748731177796 2.77268937994084e-07 miRNATAP -0.438114640201333 2.09322139503491e-10 NA NA NA hsa-miR-505-5p SCAMP5 -0.768282569967001 1.14662846595407e-05 1.15748731177796 2.77268937994084e-07 MirTarget -0.205414804894309 0.00109808235884566 NA NA NA hsa-miR-181a-5p SCAPER 0.250113435902954 0.0551933249319293 -0.367310646015773 0.0010383460763398 MirTarget -0.163535813332728 9.64852484534201e-05 NA NA NA hsa-miR-181b-5p SCAPER 0.488256489401108 0.00105321129419701 -0.367310646015773 0.0010383460763398 MirTarget -0.17761383169174 9.88648887939431e-07 NA NA NA hsa-miR-222-3p SCARB2 1.08574156066353 1.76407192348131e-11 -0.405844794428547 6.88219750589399e-07 miRNAWalker2_validate -0.164910826887902 3.67486195180214e-12 NA NA NA hsa-miR-30b-5p SCLT1 -0.54056186708617 2.44688760798341e-05 0.360667190837642 0.00177415415383484 mirMAP -0.157397415338498 0.000314561454507091 NA NA NA hsa-miR-192-5p SCMH1 -0.50188499512787 0.00344713341196035 0.430990022267255 9.70332644759149e-06 miRNAWalker2_validate -0.141555074158591 2.62835175056788e-07 NA NA NA hsa-miR-30b-5p SCML1 -0.54056186708617 2.44688760798341e-05 0.111677360556634 0.414392779208454 MirTarget -0.148342178778901 0.00411993261585625 NA NA NA hsa-miR-29c-3p SCML2 -1.4367517608807 1.61767774905781e-21 1.10658718457286 8.54027458479512e-10 MirTarget;miRNATAP -0.44529465136968 4.02100717718448e-16 NA NA NA hsa-miR-30b-5p SCML2 -0.54056186708617 2.44688760798341e-05 1.10658718457286 8.54027458479512e-10 mirMAP -0.215220512744485 0.00201251026260924 NA NA NA hsa-miR-19b-3p SCN1B 0.601279551368824 0.00016685097085251 -0.548658850513823 0.000514941323068981 miRNATAP -0.17264817438776 0.000328077082093311 NA NA NA hsa-miR-20a-5p SCN1B 0.854326758727003 5.04256669663285e-07 -0.548658850513823 0.000514941323068981 mirMAP -0.196545604647317 1.07491881096094e-05 NA NA NA hsa-miR-132-3p SCN2A 0.323796239695997 0.00272093067935091 -0.872185683333512 0.00294909111837711 MirTarget -0.395142947572944 0.00306701617220172 NA NA NA hsa-miR-182-5p SCN2A 1.96601340710222 4.39326175603633e-09 -0.872185683333512 0.00294909111837711 miRNATAP -0.155873508778122 0.000193207761827363 NA NA NA hsa-miR-432-5p SCN4A -0.536178819038888 0.0748623258271085 1.81438097558751 8.81770750257501e-15 mirMAP -0.127807970250928 0.00111313701834038 NA NA NA hsa-miR-21-5p SCN8A 1.51084295924322 1.54551622173259e-34 -0.0533720825097165 0.8138851401538 miRNATAP -0.346698629870095 2.40168964461047e-05 NA NA NA hsa-miR-30b-5p SCN8A -0.54056186708617 2.44688760798341e-05 -0.0533720825097165 0.8138851401538 MirTarget -0.20119832296569 0.0191618968049438 NA NA NA hsa-miR-148a-3p SCRN1 -0.748702855596996 3.93313343865641e-07 -0.166351597402062 0.455235320666996 mirMAP -0.565993533684603 7.92544326060182e-16 25399950 A genetic variant of miR 148a binding site in the SCRN1 3' UTR is associated with susceptibility and prognosis of gastric cancer; Using bioinformatics tools we selected two SNPs SCRN1 rs6976789 and PDYN rs2235749 located in miR-148a target sites worse prognosis gastric cancer hsa-miR-192-5p SCRN1 -0.50188499512787 0.00344713341196035 -0.166351597402062 0.455235320666996 mirMAP -0.650406147022789 2.93160025955298e-28 NA NA NA hsa-miR-455-5p SCRN1 -0.270546034117157 0.0581320703577731 -0.166351597402062 0.455235320666996 miRanda -0.512084533497426 5.84236036954717e-12 NA NA NA hsa-miR-503-5p SCRN2 0.191949282338049 0.268420664548092 0.0729264127718228 0.584890102318412 mirMAP -0.123972188695814 0.000922714402865162 NA NA NA hsa-miR-19b-3p SDC1 0.601279551368824 0.00016685097085251 -0.470843337275294 0.000957806893571993 MirTarget;miRNATAP -0.148688026990416 0.000605133639175132 NA NA NA hsa-miR-181a-5p SDC2 0.250113435902954 0.0551933249319293 -0.03087902282995 0.814769949243076 mirMAP -0.197477007832199 5.68887878744483e-05 NA NA NA hsa-miR-181b-5p SDC2 0.488256489401108 0.00105321129419701 -0.03087902282995 0.814769949243076 mirMAP -0.241361491882874 1.12082335235507e-08 NA NA NA hsa-miR-182-5p SDC2 1.96601340710222 4.39326175603633e-09 -0.03087902282995 0.814769949243076 miRNATAP -0.105321773222422 1.139484958576e-08 NA NA NA hsa-miR-192-5p SDC3 -0.50188499512787 0.00344713341196035 -0.897187533041453 1.4466200652116e-09 mirMAP -0.350631196480947 1.86371720007883e-17 NA NA NA hsa-miR-20a-5p SDCBP 0.854326758727003 5.04256669663285e-07 0.10062853278239 0.394470981999639 miRNATAP -0.189267199459337 8.47524331761686e-09 NA NA NA hsa-miR-30c-5p SDF2L1 -0.432111642767632 0.000159764714931007 0.74835587180817 2.06886879014805e-07 miRNAWalker2_validate -0.324293892390172 1.3235521916806e-07 NA NA NA hsa-miR-222-3p SDHA 1.08574156066353 1.76407192348131e-11 -0.847527561003088 1.4223709033092e-15 miRNAWalker2_validate -0.23441154321953 9.51161477094445e-14 NA NA NA hsa-miR-148a-3p SDK2 -0.748702855596996 3.93313343865641e-07 -0.809681459593403 0.027508642080261 mirMAP -0.283099945212776 0.018670514896433 NA NA NA hsa-miR-29c-3p SEC11A -1.4367517608807 1.61767774905781e-21 0.169673414091331 0.0177668124788409 MirTarget -0.100264433554812 3.99730583370628e-06 NA NA NA hsa-miR-132-3p SEC14L2 0.323796239695997 0.00272093067935091 -1.59020989986166 3.4235160920843e-08 MirTarget -1.12888854462989 8.06473393467008e-19 NA NA NA hsa-miR-503-5p SEC14L2 0.191949282338049 0.268420664548092 -1.59020989986166 3.4235160920843e-08 mirMAP -0.437864042784222 7.74399416826761e-08 NA NA NA hsa-miR-15a-5p SEC14L4 0.349521211668244 0.000770735998804736 -1.73757704803405 4.29507198180083e-07 MirTarget -0.356349317765996 0.0302596741375277 NA NA NA hsa-miR-15a-5p SEC14L5 0.349521211668244 0.000770735998804736 0.311980940356044 0.259327528499545 mirMAP -0.275447528958618 0.0347250121869964 NA NA NA hsa-miR-21-5p SEC14L5 1.51084295924322 1.54551622173259e-34 0.311980940356044 0.259327528499545 mirMAP -0.240988967484998 0.016991558309477 NA NA NA hsa-miR-132-3p SEC16A 0.323796239695997 0.00272093067935091 -0.0665051995867652 0.416479000268767 MirTarget -0.131203247206574 0.000359706617356644 NA NA NA hsa-miR-30b-5p SEC23A -0.54056186708617 2.44688760798341e-05 -0.751058909791861 9.54115837173632e-12 MirTarget -0.248884975779834 3.34667138548695e-09 NA NA NA hsa-miR-132-3p SEC24A 0.323796239695997 0.00272093067935091 -0.591377269954405 1.3877848945236e-07 MirTarget;miRNATAP -0.183220816296864 0.000364839680364065 NA NA NA hsa-miR-15a-5p SEC24A 0.349521211668244 0.000770735998804736 -0.591377269954405 1.3877848945236e-07 MirTarget;miRNATAP -0.162247009871933 0.00243111264505388 NA NA NA hsa-miR-181a-5p SEC24A 0.250113435902954 0.0551933249319293 -0.591377269954405 1.3877848945236e-07 MirTarget;miRNATAP -0.264441163428374 2.66394312198629e-10 NA NA NA hsa-miR-181b-5p SEC24A 0.488256489401108 0.00105321129419701 -0.591377269954405 1.3877848945236e-07 MirTarget;miRNATAP -0.23030008520952 2.5330299117093e-10 NA NA NA hsa-miR-132-3p SEC62 0.323796239695997 0.00272093067935091 -0.921906590113964 6.87913526550551e-31 miRNATAP -0.28407562176613 5.23832671084627e-14 NA NA NA hsa-miR-181a-5p SEC62 0.250113435902954 0.0551933249319293 -0.921906590113964 6.87913526550551e-31 mirMAP -0.150824040307635 2.23102717571015e-06 NA NA NA hsa-miR-181b-5p SEC62 0.488256489401108 0.00105321129419701 -0.921906590113964 6.87913526550551e-31 mirMAP -0.157570327188149 1.08289043000584e-08 NA NA NA hsa-miR-21-5p SEC62 1.51084295924322 1.54551622173259e-34 -0.921906590113964 6.87913526550551e-31 mirMAP -0.331904493045303 4.15393465049971e-30 NA NA NA hsa-miR-221-3p SEC62 1.12244756358612 3.48370308238012e-13 -0.921906590113964 6.87913526550551e-31 miRNATAP -0.184748336432645 6.05137407387986e-13 NA NA NA hsa-miR-222-3p SEC62 1.08574156066353 1.76407192348131e-11 -0.921906590113964 6.87913526550551e-31 miRNATAP -0.178043861621054 4.73360418546106e-13 NA NA NA hsa-miR-21-5p SEC63 1.51084295924322 1.54551622173259e-34 -0.325812925019161 4.09550265143784e-05 miRNAWalker2_validate;MirTarget -0.145396208223142 4.30963773886017e-07 NA NA NA hsa-miR-19b-3p SECISBP2L 0.601279551368824 0.00016685097085251 -0.667333440401773 2.01668926681874e-07 miRNAWalker2_validate;MirTarget -0.160788933528293 4.26701534939497e-05 NA NA NA hsa-miR-15a-5p SEL1L 0.349521211668244 0.000770735998804736 -0.497073293564348 3.72339072858383e-06 MirTarget -0.162010956182282 0.00148205215827233 NA NA NA hsa-miR-181a-5p SEL1L 0.250113435902954 0.0551933249319293 -0.497073293564348 3.72339072858383e-06 mirMAP;miRNATAP -0.184956918112765 4.55481222813321e-06 NA NA NA hsa-miR-181b-5p SEL1L 0.488256489401108 0.00105321129419701 -0.497073293564348 3.72339072858383e-06 mirMAP;miRNATAP -0.170535383069273 1.13358785386084e-06 NA NA NA hsa-miR-19b-3p SEL1L 0.601279551368824 0.00016685097085251 -0.497073293564348 3.72339072858383e-06 MirTarget -0.160606862448966 8.32113199020947e-07 NA NA NA hsa-miR-15a-5p SEL1L3 0.349521211668244 0.000770735998804736 -0.321740299766197 0.239676275511235 MirTarget -0.302812254991884 0.0188908216963976 NA NA NA hsa-miR-17-3p SELE 0.410352776142368 0.00422200500748636 -2.35025100185437 3.2370278829201e-13 miRNAWalker2_validate -0.612568898675268 3.94343075332586e-08 NA NA NA hsa-miR-181b-5p SELE 0.488256489401108 0.00105321129419701 -2.35025100185437 3.2370278829201e-13 MirTarget -0.23572975251646 0.0301557195284176 NA NA NA hsa-miR-221-3p SELE 1.12244756358612 3.48370308238012e-13 -2.35025100185437 3.2370278829201e-13 miRNAWalker2_validate -0.52896422861731 1.63448650320114e-07 NA NA NA hsa-miR-222-3p SELE 1.08574156066353 1.76407192348131e-11 -2.35025100185437 3.2370278829201e-13 miRNAWalker2_validate -0.519674469306346 8.04489670168285e-08 NA NA NA hsa-miR-181a-5p SEMA3B 0.250113435902954 0.0551933249319293 0.668562390600306 0.0188042749690616 MirTarget -0.275531147696881 0.0100605623926343 NA NA NA hsa-miR-181b-5p SEMA3B 0.488256489401108 0.00105321129419701 0.668562390600306 0.0188042749690616 MirTarget -0.234528312696168 0.011801454635489 NA NA NA hsa-miR-455-5p SEMA3C -0.270546034117157 0.0581320703577731 -1.16480784869402 0.000874995559324461 miRanda -0.398863079885428 0.000908904083072845 NA NA NA hsa-miR-15a-5p SEMA3D 0.349521211668244 0.000770735998804736 -1.42478747532489 2.53119812227229e-07 MirTarget;miRNATAP -0.294673161429966 0.0259067584079798 NA NA NA hsa-miR-455-3p SEMA3G -1.3998033821095 5.72010709806871e-17 1.12009195298451 3.90887452986156e-09 MirTarget -0.140649118145473 0.00974046858011755 NA NA NA hsa-miR-20a-5p SEMA4B 0.854326758727003 5.04256669663285e-07 -0.60655833810578 2.90170864411715e-06 MirTarget -0.161536541763846 1.16281515939978e-05 NA NA NA hsa-miR-34a-5p SEMA4B 1.03694231790865 5.74864019540594e-14 -0.60655833810578 2.90170864411715e-06 MirTarget -0.165641139866253 0.000219049717301623 NA NA NA hsa-miR-34a-5p SEMA4C 1.03694231790865 5.74864019540594e-14 -0.210793287735385 0.0381664594913213 MirTarget;miRNATAP -0.265949632799482 3.25726288707761e-15 NA NA NA hsa-miR-192-5p SEMA4D -0.50188499512787 0.00344713341196035 -0.485873273807039 0.0091347781226638 miRNAWalker2_validate -0.377262402597977 2.41600999211413e-13 NA NA NA hsa-miR-455-3p SEMA4F -1.3998033821095 5.72010709806871e-17 1.01208582172754 6.47089148904579e-05 mirMAP -0.357452755538784 4.61331396220545e-07 NA NA NA hsa-miR-132-3p SEMA4G 0.323796239695997 0.00272093067935091 -0.0601829020427669 0.724352048821439 miRNATAP -0.488361403364474 1.09077348805125e-10 NA NA NA hsa-miR-21-5p SEMA5A 1.51084295924322 1.54551622173259e-34 -1.1432007554504 2.30205619351887e-07 miRNAWalker2_validate -0.360641166634172 8.92713073935218e-06 NA NA NA hsa-miR-221-3p SEMA5A 1.12244756358612 3.48370308238012e-13 -1.1432007554504 2.30205619351887e-07 mirMAP -0.457359982916681 1.11177738447042e-11 NA NA NA hsa-miR-222-3p SEMA5A 1.08574156066353 1.76407192348131e-11 -1.1432007554504 2.30205619351887e-07 mirMAP -0.283137539151377 1.62779166594656e-05 NA NA NA hsa-miR-20a-5p SEMA6A 0.854326758727003 5.04256669663285e-07 -1.01308253607629 9.68055629258042e-05 mirMAP -0.150178925515583 0.0433463436385315 NA NA NA hsa-miR-30c-5p SEMA6B -0.432111642767632 0.000159764714931007 0.498651824179604 0.000243716519895294 MirTarget -0.183818583727324 0.00156153005818045 NA NA NA hsa-miR-30e-5p SEMA6B -0.627815042856657 3.02205690184908e-10 0.498651824179604 0.000243716519895294 MirTarget -0.253653411887117 0.000114040210470108 NA NA NA hsa-miR-15a-5p SEMA6D 0.349521211668244 0.000770735998804736 -1.73527979620398 1.31444245208132e-15 miRNATAP -0.418346694566149 7.32846457038186e-05 NA NA NA hsa-miR-19b-3p SEMA6D 0.601279551368824 0.00016685097085251 -1.73527979620398 1.31444245208132e-15 miRNATAP -0.187590730286424 0.00606718237099467 NA NA NA hsa-miR-221-3p SEMA6D 1.12244756358612 3.48370308238012e-13 -1.73527979620398 1.31444245208132e-15 mirMAP;miRNATAP -0.307723746797562 7.41427256696092e-06 NA NA NA hsa-miR-222-3p SEMA6D 1.08574156066353 1.76407192348131e-11 -1.73527979620398 1.31444245208132e-15 miRNATAP -0.206197753477734 0.00186982540405591 NA NA NA hsa-miR-20a-5p SEMA7A 0.854326758727003 5.04256669663285e-07 1.19314988680133 1.05996526123706e-06 MirTarget;miRNATAP -0.141546898688235 0.0440315622619618 NA NA NA hsa-miR-27b-3p SEMA7A -0.823491817819754 9.20935302746823e-14 1.19314988680133 1.05996526123706e-06 MirTarget;miRNATAP -0.46815610817365 9.84838265036026e-06 NA NA NA hsa-miR-29c-3p SENP1 -1.4367517608807 1.61767774905781e-21 0.459163816376363 1.4816891960384e-08 miRNATAP -0.192276220240101 3.89466104677117e-15 NA NA NA hsa-miR-30c-5p SENP3 -0.432111642767632 0.000159764714931007 0.255032626756023 0.000623266942599625 miRNAWalker2_validate -0.119801567916944 0.000150513767311267 NA NA NA hsa-miR-132-3p SEPSECS 0.323796239695997 0.00272093067935091 -1.01697472631097 3.96874363132228e-15 miRNATAP -0.557621880735348 4.31875716809667e-22 NA NA NA hsa-miR-182-5p SEPSECS 1.96601340710222 4.39326175603633e-09 -1.01697472631097 3.96874363132228e-15 miRNATAP -0.107931090770089 9.21928568317258e-09 NA NA NA hsa-miR-146b-5p SEPT3 0.419719546795449 0.0457375823220155 2.04173059346372 1.46360544494342e-11 mirMAP;miRNATAP -0.243734961573927 0.000681529188747089 NA NA NA hsa-miR-455-3p SEPT5 -1.3998033821095 5.72010709806871e-17 1.6037468893919 4.05188328509163e-12 PITA -0.289003637844787 1.26613796197989e-05 NA NA NA hsa-miR-146b-5p SEPT6 0.419719546795449 0.0457375823220155 0.198641188497735 0.243185306491161 miRanda -0.159128109177956 4.89793336743268e-05 NA NA NA hsa-miR-455-3p SEPT6 -1.3998033821095 5.72010709806871e-17 0.198641188497735 0.243185306491161 PITA;miRNATAP -0.160228297326162 0.000759282805117348 NA NA NA hsa-miR-192-3p SEPT7 -0.6401165114007 0.000266272092403814 0.0368475941839144 0.549740114951762 MirTarget -0.105306529618456 1.77844702951912e-10 NA NA NA hsa-miR-30e-5p SEPT8 -0.627815042856657 3.02205690184908e-10 0.761947942489662 8.46348824111217e-18 mirMAP;miRNATAP -0.166017796977308 0.000181529215555808 NA NA NA hsa-miR-148a-3p SEPT9 -0.748702855596996 3.93313343865641e-07 0.491611991206742 1.43369490340499e-09 mirMAP -0.217299710958597 5.96744758598083e-17 NA NA NA hsa-miR-19b-3p SERINC3 0.601279551368824 0.00016685097085251 -0.331460551281738 5.22316177237787e-05 miRNAWalker2_validate;MirTarget -0.110114534537477 8.91342016184423e-06 NA NA NA hsa-miR-132-3p SERP1 0.323796239695997 0.00272093067935091 -0.252864286371366 0.000556618706050377 MirTarget -0.195698377166968 2.01495442465144e-09 NA NA NA hsa-miR-148a-3p SERPINE1 -0.748702855596996 3.93313343865641e-07 -2.5626204615753 1.45202766560285e-19 miRNATAP -0.208585842910118 0.0317546494376279 NA NA NA hsa-miR-34a-5p SERPINE1 1.03694231790865 5.74864019540594e-14 -2.5626204615753 1.45202766560285e-19 miRNATAP -0.399999110948681 8.04313907897335e-05 NA NA NA hsa-miR-34a-5p SERPINF2 1.03694231790865 5.74864019540594e-14 -1.78479428666712 4.94002221824644e-11 MirTarget -0.232878882974941 0.0148934215936048 NA NA NA hsa-miR-29c-3p SERPINH1 -1.4367517608807 1.61767774905781e-21 0.857204942663188 1.18245152144085e-10 miRNATAP -0.352115575249427 1.86537676248473e-18 NA NA NA hsa-miR-21-5p SESN1 1.51084295924322 1.54551622173259e-34 -0.582017748855085 1.56850305646972e-06 miRNAWalker2_validate -0.309095857741543 1.28235786632969e-12 NA NA NA hsa-miR-181a-5p SESN3 0.250113435902954 0.0551933249319293 -0.821541570789657 0.00383798636487833 MirTarget -0.319299217345204 0.00282677245748294 NA NA NA hsa-miR-181b-5p SESN3 0.488256489401108 0.00105321129419701 -0.821541570789657 0.00383798636487833 MirTarget -0.324236880289917 0.00047836521786657 NA NA NA hsa-miR-192-3p SESN3 -0.6401165114007 0.000266272092403814 -0.821541570789657 0.00383798636487833 MirTarget -0.155864153431608 0.0483528915048638 NA NA NA hsa-miR-20a-5p SESN3 0.854326758727003 5.04256669663285e-07 -0.821541570789657 0.00383798636487833 MirTarget -0.40024159648166 5.55264508290224e-07 NA NA NA hsa-miR-148a-3p SESTD1 -0.748702855596996 3.93313343865641e-07 0.726908919315734 4.26585328930009e-09 miRNAWalker2_validate;MirTarget;miRNATAP -0.109379528086166 0.00785482875672258 NA NA NA hsa-miR-29c-3p SESTD1 -1.4367517608807 1.61767774905781e-21 0.726908919315734 4.26585328930009e-09 MirTarget;miRNATAP -0.156439214943404 4.92756998156353e-05 NA NA NA hsa-miR-192-5p SETD4 -0.50188499512787 0.00344713341196035 0.822795103734063 1.19357180170398e-22 miRNAWalker2_validate -0.116180063788143 2.89418575414034e-06 NA NA NA hsa-miR-20a-5p SETD7 0.854326758727003 5.04256669663285e-07 -0.645690628283917 3.04188071973992e-07 mirMAP -0.234270603961015 3.61885872394216e-11 NA NA NA hsa-miR-20b-5p SETD7 0.457668023910379 0.0285865211936156 -0.645690628283917 3.04188071973992e-07 mirMAP -0.102690446194434 0.000532319708814832 NA NA NA hsa-miR-455-5p SETD7 -0.270546034117157 0.0581320703577731 -0.645690628283917 3.04188071973992e-07 miRanda -0.109782082340743 0.0120811654522084 NA NA NA hsa-miR-29c-3p SETDB1 -1.4367517608807 1.61767774905781e-21 0.93930817996481 2.48480438198869e-25 MirTarget;miRNATAP -0.225150346459695 2.92825266918727e-15 NA NA NA hsa-miR-181a-5p SFMBT1 0.250113435902954 0.0551933249319293 -0.127597815189636 0.161968044655003 MirTarget;miRNATAP -0.116421079686356 0.000618890534185046 NA NA NA hsa-miR-181b-5p SFMBT1 0.488256489401108 0.00105321129419701 -0.127597815189636 0.161968044655003 MirTarget;miRNATAP -0.138926235179052 2.29177066830722e-06 NA NA NA hsa-miR-192-3p SFMBT2 -0.6401165114007 0.000266272092403814 -0.653813685456887 0.0100525670943711 MirTarget -0.349379958984861 5.17242445705488e-07 NA NA NA hsa-miR-29c-3p SFPQ -1.4367517608807 1.61767774905781e-21 0.125568329226642 0.0568093957704412 MirTarget;miRNATAP -0.120084355408337 1.29602660300032e-09 NA NA NA hsa-miR-146b-5p SFRP1 0.419719546795449 0.0457375823220155 -4.14637823674297 1.04005427998815e-32 MirTarget -0.215066445935128 0.0140810441727555 NA NA NA hsa-miR-182-5p SFRP1 1.96601340710222 4.39326175603633e-09 -4.14637823674297 1.04005427998815e-32 mirMAP -0.129762765663797 0.015988108793524 NA NA NA hsa-miR-192-3p SFRP1 -0.6401165114007 0.000266272092403814 -4.14637823674297 1.04005427998815e-32 MirTarget -0.424962367232444 4.17845072192868e-05 NA NA NA hsa-miR-455-5p SFRP2 -0.270546034117157 0.0581320703577731 0.468120194073395 0.289027671938249 miRanda -0.795717260851726 9.71330692924213e-08 NA NA NA hsa-miR-146b-5p SFRP5 0.419719546795449 0.0457375823220155 -6.77024588580237 2.41839018283144e-29 miRanda -0.322537811676363 0.0319024958905886 NA NA NA hsa-miR-20a-5p SFXN1 0.854326758727003 5.04256669663285e-07 -0.990318290801911 5.86324585320089e-17 mirMAP -0.143191583848751 3.53525790156213e-05 NA NA NA hsa-miR-21-5p SFXN1 1.51084295924322 1.54551622173259e-34 -0.990318290801911 5.86324585320089e-17 miRNAWalker2_validate -0.394828254121738 3.12485232263999e-20 NA NA NA hsa-miR-132-3p SFXN2 0.323796239695997 0.00272093067935091 -0.985470809227409 2.83961790885963e-10 miRNAWalker2_validate -0.534445452764041 2.75961454942561e-14 NA NA NA hsa-miR-15a-5p SGCA 0.349521211668244 0.000770735998804736 -2.48559697058161 1.91437305089774e-12 MirTarget -0.855298612094395 4.31950597435003e-07 NA NA NA hsa-miR-192-5p SGCB -0.50188499512787 0.00344713341196035 -0.991863016074027 7.13504872359113e-06 miRNAWalker2_validate -0.154794352463484 0.0145231978761119 NA NA NA hsa-miR-21-5p SGCB 1.51084295924322 1.54551622173259e-34 -0.991863016074027 7.13504872359113e-06 miRNAWalker2_validate -0.408063134168544 4.09056141654257e-07 NA NA NA hsa-miR-146b-5p SGCD 0.419719546795449 0.0457375823220155 -2.19675212080742 3.14480928648648e-10 mirMAP -0.164742793456498 0.0469934887751068 NA NA NA hsa-miR-15a-5p SGCD 0.349521211668244 0.000770735998804736 -2.19675212080742 3.14480928648648e-10 miRNATAP -0.603284840336993 0.000319777839971041 NA NA NA hsa-miR-19b-3p SGCD 0.601279551368824 0.00016685097085251 -2.19675212080742 3.14480928648648e-10 mirMAP -0.521974176567477 1.17565847476234e-06 NA NA NA hsa-miR-20a-5p SGCD 0.854326758727003 5.04256669663285e-07 -2.19675212080742 3.14480928648648e-10 mirMAP -0.68633576289089 3.5926399780433e-12 NA NA NA hsa-miR-21-5p SGK3 1.51084295924322 1.54551622173259e-34 -0.235888881337767 0.0629928865889445 miRNAWalker2_validate -0.158120464091527 0.000607322860528501 NA NA NA hsa-miR-17-3p SGPP1 0.410352776142368 0.00422200500748636 -0.885203784817445 2.63061154305831e-17 MirTarget -0.229573812749929 2.3470410824793e-10 NA NA NA hsa-miR-34a-5p SGPP1 1.03694231790865 5.74864019540594e-14 -0.885203784817445 2.63061154305831e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.116479304953135 0.00177856818092071 NA NA NA hsa-miR-99a-5p SGPP2 -1.51481656384839 3.93230057259529e-14 -0.421003821219622 0.254140451006052 miRNAWalker2_validate -0.469687156053051 4.44594596792026e-08 NA NA NA hsa-miR-27b-3p SGTB -0.823491817819754 9.20935302746823e-14 0.0810874123995056 0.438106771519805 MirTarget -0.161027975428053 0.000318010100863441 NA NA NA hsa-miR-20a-5p SH2B3 0.854326758727003 5.04256669663285e-07 -0.362619555502857 0.00114081856769928 MirTarget -0.109838156162695 0.000502146107066274 NA NA NA hsa-miR-505-5p SH2D5 -0.768282569967001 1.14662846595407e-05 1.15452129075747 4.29119316917744e-05 mirMAP -0.24318615567657 0.00193699150714249 NA NA NA hsa-miR-15a-5p SH3BGRL2 0.349521211668244 0.000770735998804736 -0.967834191230422 9.67498247511188e-10 miRNATAP -0.173865417526127 0.0224364824831512 NA NA NA hsa-miR-21-5p SH3BGRL2 1.51084295924322 1.54551622173259e-34 -0.967834191230422 9.67498247511188e-10 mirMAP -0.509292184634394 1.69575741221457e-19 NA NA NA hsa-miR-224-3p SH3BGRL2 1.40770116795301 1.31426607144612e-08 -0.967834191230422 9.67498247511188e-10 mirMAP -0.10939451505912 0.000520319753120399 NA NA NA hsa-miR-455-5p SH3BGRL3 -0.270546034117157 0.0581320703577731 0.170796376370744 0.187558849231191 miRanda -0.158934388413326 0.000317163272074431 NA NA NA hsa-miR-182-5p SH3BP4 1.96601340710222 4.39326175603633e-09 -0.172046131729646 0.234489669983901 miRNATAP -0.100625218766497 7.91226663942211e-07 NA NA NA hsa-miR-20a-5p SH3BP5 0.854326758727003 5.04256669663285e-07 -0.719247176940928 1.59549442781556e-06 miRNATAP -0.278297162107647 3.51453217893864e-11 NA NA NA hsa-miR-29c-3p SH3BP5L -1.4367517608807 1.61767774905781e-21 0.877049264079259 5.88036761472054e-24 miRNATAP -0.134204296002624 1.60363549088507e-06 NA NA NA hsa-miR-19b-3p SH3D19 0.601279551368824 0.00016685097085251 -0.821482116094042 8.83871291011707e-11 MirTarget;miRNATAP -0.241743004532401 3.72642810164192e-10 NA NA NA hsa-miR-27b-3p SH3GL3 -0.823491817819754 9.20935302746823e-14 0.563667600337586 0.172947352730134 miRNATAP -0.380394510388594 0.0330889860400037 NA NA NA hsa-miR-20a-5p SH3GLB1 0.854326758727003 5.04256669663285e-07 -0.324993114681338 1.11759082275534e-06 MirTarget -0.139846663138945 3.41550667393548e-14 NA NA NA hsa-miR-455-5p SH3GLB1 -0.270546034117157 0.0581320703577731 -0.324993114681338 1.11759082275534e-06 miRanda -0.143671110803357 1.75656772353109e-10 NA NA NA hsa-miR-29c-3p SH3PXD2A -1.4367517608807 1.61767774905781e-21 0.416720664438486 0.000333370925413981 MirTarget;miRNATAP -0.204906617839135 6.66824263285911e-09 NA NA NA hsa-miR-505-5p SH3PXD2B -0.768282569967001 1.14662846595407e-05 1.18897966754677 1.69468440699002e-21 mirMAP -0.167242869426405 3.23485350846616e-06 NA NA NA hsa-miR-146b-5p SH3RF1 0.419719546795449 0.0457375823220155 -0.764600709647254 7.09288463616756e-07 miRanda -0.169462541716424 2.29631529217938e-06 NA NA NA hsa-miR-30b-5p SH3RF2 -0.54056186708617 2.44688760798341e-05 0.279560747455942 0.242543606773245 mirMAP -0.193120770808181 0.0333568028025171 NA NA NA hsa-miR-17-3p SH3RF3 0.410352776142368 0.00422200500748636 0.372077452583573 0.136814784242837 mirMAP -0.575685161652832 3.96216872478914e-12 NA NA NA hsa-miR-192-5p SH3RF3 -0.50188499512787 0.00344713341196035 0.372077452583573 0.136814784242837 MirTarget;miRNATAP -0.576427639323703 3.05022832647926e-17 NA NA NA hsa-miR-19b-3p SH3RF3 0.601279551368824 0.00016685097085251 0.372077452583573 0.136814784242837 MirTarget;miRNATAP -0.364532689926478 1.2634453672483e-06 NA NA NA hsa-miR-215-5p SH3RF3 -0.981544773246509 3.14452272477156e-05 0.372077452583573 0.136814784242837 MirTarget -0.227076889410134 7.90294367330046e-06 NA NA NA hsa-miR-455-5p SH3TC2 -0.270546034117157 0.0581320703577731 -0.0135983841550522 0.943126272657465 miRanda -0.239140244913163 0.000229001852685429 NA NA NA hsa-miR-146b-5p SH3YL1 0.419719546795449 0.0457375823220155 -1.13152108482008 1.62722765057601e-07 MirTarget;miRanda -0.185202048905994 0.000254880371896773 NA NA NA hsa-miR-132-3p SHANK2 0.323796239695997 0.00272093067935091 0.0332648665683903 0.871563208301543 mirMAP -0.339137180553041 0.000258030269296242 NA NA NA hsa-miR-146b-5p SHANK2 0.419719546795449 0.0457375823220155 0.0332648665683903 0.871563208301543 mirMAP -0.107454897402365 0.0242175544319586 NA NA NA hsa-miR-148a-3p SHC3 -0.748702855596996 3.93313343865641e-07 1.52510778944018 2.16327808412124e-07 MirTarget -0.266138626489331 0.00635514525014243 NA NA NA hsa-miR-455-3p SHCBP1 -1.3998033821095 5.72010709806871e-17 3.10163168776454 4.23057100093613e-34 miRNAWalker2_validate -0.490824522158229 1.20781253311036e-10 NA NA NA hsa-miR-17-3p SHISA9 0.410352776142368 0.00422200500748636 -1.20843414172775 0.000663916656116767 MirTarget;miRNATAP -0.379633049047152 0.00173341653301442 NA NA NA hsa-miR-20a-5p SHISA9 0.854326758727003 5.04256669663285e-07 -1.20843414172775 0.000663916656116767 mirMAP -0.352548674263272 0.000473298312175861 NA NA NA hsa-miR-19b-3p SHROOM3 0.601279551368824 0.00016685097085251 -0.756340398661211 7.73287025254187e-05 mirMAP -0.176225770823323 0.00259239850556008 NA NA NA hsa-miR-15a-5p SHROOM4 0.349521211668244 0.000770735998804736 0.38170789610378 0.0117604023519324 miRNATAP -0.260195567035033 0.00025862419807093 NA NA NA hsa-miR-20a-5p SHROOM4 0.854326758727003 5.04256669663285e-07 0.38170789610378 0.0117604023519324 mirMAP -0.15930269229914 0.000198676259188657 NA NA NA hsa-miR-455-5p SIAE -0.270546034117157 0.0581320703577731 -0.883928221756694 1.39236089477694e-07 miRanda -0.169980198036843 0.00352768166844084 NA NA NA hsa-miR-146a-5p SIAH2 -0.742958238440575 0.000765983177482633 -0.180852424374594 0.16408312485548 MirTarget -0.104812744627083 0.000220709773982069 NA NA NA hsa-miR-214-5p SIAH2 -1.91497809567701 3.92955595018147e-12 -0.180852424374594 0.16408312485548 MirTarget -0.103951120226821 3.50707761136445e-06 NA NA NA hsa-miR-503-5p SIAH2 0.191949282338049 0.268420664548092 -0.180852424374594 0.16408312485548 miRNAWalker2_validate -0.147734075068657 4.79741640122438e-05 NA NA NA hsa-miR-34a-5p SIDT1 1.03694231790865 5.74864019540594e-14 -0.422483661613941 0.0341509067273572 miRNATAP -0.147531567659471 0.0317023781873922 NA NA NA hsa-miR-30e-5p SIGLEC8 -0.627815042856657 3.02205690184908e-10 -1.43739210584729 4.25283678534772e-07 MirTarget -0.363793133330519 0.00903286733946604 NA NA NA hsa-miR-15a-5p SIK1 0.349521211668244 0.000770735998804736 -1.56281900212212 2.20390485809155e-13 MirTarget;miRNATAP -0.433036014791789 2.52463916664006e-05 NA NA NA hsa-miR-182-5p SIK1 1.96601340710222 4.39326175603633e-09 -1.56281900212212 2.20390485809155e-13 miRNATAP -0.141264073821549 5.35336517819928e-06 NA NA NA hsa-miR-20a-5p SIK1 0.854326758727003 5.04256669663285e-07 -1.56281900212212 2.20390485809155e-13 MirTarget;miRNATAP -0.188334637550677 0.00243717192295782 NA NA NA hsa-miR-20b-5p SIK1 0.457668023910379 0.0285865211936156 -1.56281900212212 2.20390485809155e-13 MirTarget;miRNATAP -0.166874106875274 0.0010735286371609 NA NA NA hsa-miR-181a-5p SIK2 0.250113435902954 0.0551933249319293 -0.542824528961952 3.47126109215308e-05 miRNAWalker2_validate -0.158560045900552 0.00135140540806299 NA NA NA hsa-miR-181a-5p SIK3 0.250113435902954 0.0551933249319293 -0.558299327637913 1.91997192491462e-09 MirTarget -0.100373037256947 0.00464186496383217 NA NA NA hsa-miR-181b-5p SIK3 0.488256489401108 0.00105321129419701 -0.558299327637913 1.91997192491462e-09 MirTarget -0.109919569927828 0.000351491748797864 NA NA NA hsa-miR-30b-5p SIK3 -0.54056186708617 2.44688760798341e-05 -0.558299327637913 1.91997192491462e-09 mirMAP -0.105511469247181 0.00320241484685814 NA NA NA hsa-miR-21-5p SIKE1 1.51084295924322 1.54551622173259e-34 -0.25247843404849 0.000535002945958211 mirMAP -0.163668491824083 3.51523764041468e-10 NA NA NA hsa-miR-30b-5p SIKE1 -0.54056186708617 2.44688760798341e-05 -0.25247843404849 0.000535002945958211 MirTarget;mirMAP -0.107655459646118 8.97978517405574e-05 NA NA NA hsa-miR-19b-3p SIPA1L1 0.601279551368824 0.00016685097085251 -0.0168650073353556 0.837383768861183 MirTarget -0.114132281474042 3.46803296129295e-06 NA NA NA hsa-miR-20a-5p SIRPA 0.854326758727003 5.04256669663285e-07 -0.71524536340462 3.11665477449842e-07 miRNAWalker2_validate -0.185170761493752 3.23452227601708e-06 NA NA NA hsa-miR-132-3p SIRT1 0.323796239695997 0.00272093067935091 -0.851284120733399 2.9344741272993e-11 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.257351134001732 1.28849688297175e-05 NA NA NA hsa-miR-181a-5p SIRT1 0.250113435902954 0.0551933249319293 -0.851284120733399 2.9344741272993e-11 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.13610269518638 0.00562959271844008 NA NA NA hsa-miR-181b-5p SIRT1 0.488256489401108 0.00105321129419701 -0.851284120733399 2.9344741272993e-11 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.165616125888402 0.000100128448749756 NA NA NA hsa-miR-148a-3p SIX4 -0.748702855596996 3.93313343865641e-07 2.61579593202535 2.3706138390953e-15 miRNATAP -0.567991524754382 2.80120759528324e-07 NA NA NA hsa-miR-192-5p SIX4 -0.50188499512787 0.00344713341196035 2.61579593202535 2.3706138390953e-15 miRNAWalker2_validate -0.375289735370248 0.000102213669676659 NA NA NA hsa-miR-215-5p SIX4 -0.981544773246509 3.14452272477156e-05 2.61579593202535 2.3706138390953e-15 miRNAWalker2_validate -0.235780513264725 0.000747558838445851 NA NA NA hsa-miR-30c-5p SIX4 -0.432111642767632 0.000159764714931007 2.61579593202535 2.3706138390953e-15 miRNATAP -0.447795659140626 0.00211012462279394 NA NA NA hsa-miR-215-5p SKA1 -0.981544773246509 3.14452272477156e-05 4.36401671227727 6.25563819546619e-53 miRNAWalker2_validate -0.159469837029539 0.0167794241606712 NA NA NA hsa-miR-27b-3p SKA3 -0.823491817819754 9.20935302746823e-14 3.70437460242013 6.48201535159511e-47 MirTarget -0.618146032186515 5.5003056347753e-07 NA NA NA hsa-miR-21-5p SKI 1.51084295924322 1.54551622173259e-34 -0.298904352736227 0.00375499820753305 MirTarget;miRNATAP -0.257048686823694 2.62914030320397e-12 NA NA NA hsa-miR-21-5p SKP2 1.51084295924322 1.54551622173259e-34 0.422595289761893 0.0200334942687184 miRNAWalker2_validate;MirTarget -0.199555879642397 0.00262016397392478 NA NA NA hsa-miR-30b-5p SKP2 -0.54056186708617 2.44688760798341e-05 0.422595289761893 0.0200334942687184 MirTarget;miRNATAP -0.240712598784266 0.000463630582388284 NA NA NA hsa-miR-455-5p SLA -0.270546034117157 0.0581320703577731 -1.01789804324436 2.8651666830365e-07 miRanda -0.302706094056878 9.50209631386996e-06 NA NA NA hsa-miR-181a-5p SLAIN2 0.250113435902954 0.0551933249319293 -0.37865756950093 8.79283914288049e-08 MirTarget -0.126978294183693 1.73220249527452e-06 NA NA NA hsa-miR-181b-5p SLAIN2 0.488256489401108 0.00105321129419701 -0.37865756950093 8.79283914288049e-08 MirTarget -0.122297396502063 1.08434431919206e-07 NA NA NA hsa-miR-20a-5p SLAIN2 0.854326758727003 5.04256669663285e-07 -0.37865756950093 8.79283914288049e-08 MirTarget;miRNATAP -0.143824678103796 2.74641556653432e-13 NA NA NA hsa-miR-21-5p SLAIN2 1.51084295924322 1.54551622173259e-34 -0.37865756950093 8.79283914288049e-08 miRNAWalker2_validate -0.16620781375253 7.34738059339728e-11 NA NA NA hsa-miR-15a-5p SLC12A2 0.349521211668244 0.000770735998804736 -0.491172071796036 0.0265051390992754 MirTarget;miRNATAP -0.342748988015024 0.00100552975266331 NA NA NA hsa-miR-34a-5p SLC12A2 1.03694231790865 5.74864019540594e-14 -0.491172071796036 0.0265051390992754 miRNATAP -0.338968012415163 7.25438143409526e-06 NA NA NA hsa-miR-455-3p SLC12A2 -1.3998033821095 5.72010709806871e-17 -0.491172071796036 0.0265051390992754 PITA -0.178508567870473 0.00408763520850358 NA NA NA hsa-miR-30b-5p SLC12A6 -0.54056186708617 2.44688760798341e-05 -0.160897478711137 0.108027692964013 MirTarget -0.140547690099831 0.00019173060264824 NA NA NA hsa-miR-19b-3p SLC14A1 0.601279551368824 0.00016685097085251 -1.49982946868094 2.66839496478096e-09 MirTarget -0.334401348127297 1.61807268910967e-05 NA NA NA hsa-miR-21-5p SLC16A10 1.51084295924322 1.54551622173259e-34 -1.40592334895919 3.67016779027723e-07 miRNAWalker2_validate -0.637594864437139 2.07184643565534e-10 NA NA NA hsa-miR-224-3p SLC16A12 1.40770116795301 1.31426607144612e-08 -0.582701560249782 0.124002938826254 mirMAP -0.158352915124395 0.0331183999403127 NA NA NA hsa-miR-146b-5p SLC16A14 0.419719546795449 0.0457375823220155 0.013046081364418 0.962601334943825 PITA;miRanda -0.137720827225212 0.032800152339453 NA NA NA hsa-miR-29c-3p SLC16A3 -1.4367517608807 1.61767774905781e-21 0.84939478908221 0.000243885545657241 mirMAP -0.231157384452317 0.00124225101888511 NA NA NA hsa-miR-455-3p SLC16A3 -1.3998033821095 5.72010709806871e-17 0.84939478908221 0.000243885545657241 PITA -0.373291740791798 6.69149854688666e-09 NA NA NA hsa-miR-148a-3p SLC16A6 -0.748702855596996 3.93313343865641e-07 -0.236488661429015 0.313225012355655 MirTarget;miRNATAP -0.276157865502067 0.00029453291851848 NA NA NA hsa-miR-192-5p SLC16A6 -0.50188499512787 0.00344713341196035 -0.236488661429015 0.313225012355655 miRNAWalker2_validate -0.167554938859513 0.0116923570848654 NA NA NA hsa-miR-192-5p SLC16A7 -0.50188499512787 0.00344713341196035 -1.26418567420408 1.8151156622962e-05 miRNAWalker2_validate -0.25450344115478 0.00254476446577388 NA NA NA hsa-miR-194-5p SLC16A9 -0.292530160992458 0.0996141384876663 -1.06090990279424 0.0194477008756128 miRNAWalker2_validate -0.258258730084338 0.0391771783470697 NA NA NA hsa-miR-181a-5p SLC19A2 0.250113435902954 0.0551933249319293 -0.593493725054049 5.01535540839479e-05 MirTarget -0.231589086186535 2.53268521484402e-05 NA NA NA hsa-miR-181b-5p SLC19A2 0.488256489401108 0.00105321129419701 -0.593493725054049 5.01535540839479e-05 MirTarget -0.239459091461628 4.92960361161557e-07 NA NA NA hsa-miR-146b-5p SLC1A1 0.419719546795449 0.0457375823220155 -2.48716408312787 1.83542966329299e-11 miRanda;miRNATAP -0.24106145445651 0.00617684422681936 NA NA NA hsa-miR-182-5p SLC1A1 1.96601340710222 4.39326175603633e-09 -2.48716408312787 1.83542966329299e-11 miRNATAP -0.127112378170108 0.0189894815550205 NA NA NA hsa-miR-132-3p SLC1A2 0.323796239695997 0.00272093067935091 -2.05184743338733 5.07102901300161e-06 mirMAP -0.956453431588867 2.91385434922455e-06 NA NA NA hsa-miR-146a-5p SLC1A2 -0.742958238440575 0.000765983177482633 -2.05184743338733 5.07102901300161e-06 mirMAP -0.324231558517715 0.00114338685917044 NA NA NA hsa-miR-17-3p SLC1A2 0.410352776142368 0.00422200500748636 -2.05184743338733 5.07102901300161e-06 mirMAP -0.512253479065871 0.000900719851796207 NA NA NA hsa-miR-182-5p SLC1A2 1.96601340710222 4.39326175603633e-09 -2.05184743338733 5.07102901300161e-06 MirTarget;miRNATAP -0.493633112723223 3.74452006461092e-15 NA NA NA hsa-miR-19b-3p SLC1A2 0.601279551368824 0.00016685097085251 -2.05184743338733 5.07102901300161e-06 miRNATAP -0.327628988944869 0.0178642801113856 NA NA NA hsa-miR-20a-5p SLC1A2 0.854326758727003 5.04256669663285e-07 -2.05184743338733 5.07102901300161e-06 miRNATAP -0.315519514745736 0.0144392641505683 NA NA NA hsa-miR-20b-5p SLC1A2 0.457668023910379 0.0285865211936156 -2.05184743338733 5.07102901300161e-06 miRNATAP -0.361134940019828 0.000630674787765741 NA NA NA hsa-miR-224-3p SLC1A2 1.40770116795301 1.31426607144612e-08 -2.05184743338733 5.07102901300161e-06 mirMAP -0.284569783357791 0.00137282150228346 NA NA NA hsa-miR-455-3p SLC1A3 -1.3998033821095 5.72010709806871e-17 1.06581364763457 8.88198421254159e-07 PITA;miRNATAP -0.353477460359874 5.64462601090098e-09 NA NA NA hsa-miR-455-5p SLC1A3 -0.270546034117157 0.0581320703577731 1.06581364763457 8.88198421254159e-07 miRanda -0.387956685175211 1.78547560824473e-07 NA NA NA hsa-miR-34a-5p SLC1A5 1.03694231790865 5.74864019540594e-14 0.117133194597657 0.610333433839322 miRNAWalker2_validate -0.357277542548374 4.91320143037089e-06 NA NA NA hsa-miR-15a-5p SLC20A2 0.349521211668244 0.000770735998804736 -0.68218249424573 3.91735961922429e-06 miRNATAP -0.167669141618778 0.0172451888459569 NA NA NA hsa-miR-182-5p SLC22A11 1.96601340710222 4.39326175603633e-09 1.94604828124755 0.000773219228900025 mirMAP -0.28078774251077 0.000692148924905764 NA NA NA hsa-miR-505-5p SLC22A15 -0.768282569967001 1.14662846595407e-05 1.05635935807366 0.00201382112271283 MirTarget -0.23686579026639 0.0125601291756233 NA NA NA hsa-miR-27b-3p SLC22A23 -0.823491817819754 9.20935302746823e-14 0.632125395741205 5.61389746801226e-07 MirTarget;miRNATAP -0.253238840747903 3.52193146511478e-06 NA NA NA hsa-miR-132-3p SLC22A3 0.323796239695997 0.00272093067935091 -1.9854213857181 3.33178978711179e-12 MirTarget -0.923519437497928 9.95486022940582e-13 NA NA NA hsa-miR-181a-5p SLC22A3 0.250113435902954 0.0551933249319293 -1.9854213857181 3.33178978711179e-12 mirMAP -0.58334773149194 7.76587868293524e-08 NA NA NA hsa-miR-181b-5p SLC22A3 0.488256489401108 0.00105321129419701 -1.9854213857181 3.33178978711179e-12 mirMAP -0.664246012711787 1.04662788141655e-12 NA NA NA hsa-miR-455-5p SLC22A4 -0.270546034117157 0.0581320703577731 1.10791605313628 7.21707753732095e-06 miRanda -0.193784927974949 0.0235027353163076 NA NA NA hsa-miR-181a-5p SLC23A2 0.250113435902954 0.0551933249319293 -0.584703803315866 0.0010236404080005 mirMAP -0.349279944462148 1.38042224509108e-07 NA NA NA hsa-miR-181b-5p SLC23A2 0.488256489401108 0.00105321129419701 -0.584703803315866 0.0010236404080005 mirMAP -0.367598727245575 1.32097607325811e-10 NA NA NA hsa-miR-148a-3p SLC24A3 -0.748702855596996 3.93313343865641e-07 -1.47084747826355 6.82498530848671e-06 MirTarget;miRNATAP -0.89028739568033 1.00504027954793e-17 NA NA NA hsa-miR-15a-5p SLC24A3 0.349521211668244 0.000770735998804736 -1.47084747826355 6.82498530848671e-06 miRNATAP -0.760090470822769 8.15181919892447e-07 NA NA NA hsa-miR-19b-3p SLC24A3 0.601279551368824 0.00016685097085251 -1.47084747826355 6.82498530848671e-06 MirTarget;miRNATAP -0.376040529040311 0.000169220371900284 NA NA NA hsa-miR-222-3p SLC25A10 1.08574156066353 1.76407192348131e-11 -0.18513947836735 0.179262152010489 miRNAWalker2_validate -0.246928768933771 5.77220314380505e-10 NA NA NA hsa-miR-146b-5p SLC25A24 0.419719546795449 0.0457375823220155 -0.550300544089223 0.0245744787663875 miRanda -0.120068932623615 0.0349512049244855 NA NA NA hsa-miR-181a-5p SLC25A25 0.250113435902954 0.0551933249319293 -1.10505911433835 5.5242474077183e-09 MirTarget;miRNATAP -0.296961697653963 3.74056924300149e-05 NA NA NA hsa-miR-181b-5p SLC25A25 0.488256489401108 0.00105321129419701 -1.10505911433835 5.5242474077183e-09 MirTarget;miRNATAP -0.321583489702475 2.43987828502607e-07 NA NA NA hsa-miR-146b-5p SLC25A34 0.419719546795449 0.0457375823220155 -0.523432989408835 0.0214753396435232 miRanda -0.225556886808567 1.73796488171642e-05 NA NA NA hsa-miR-30b-5p SLC25A34 -0.54056186708617 2.44688760798341e-05 -0.523432989408835 0.0214753396435232 MirTarget -0.234909384168982 0.00655919261458703 NA NA NA hsa-miR-181a-5p SLC25A37 0.250113435902954 0.0551933249319293 -0.718161877117594 9.11526444419931e-09 MirTarget -0.142026655194208 0.002867940251803 NA NA NA hsa-miR-181b-5p SLC25A37 0.488256489401108 0.00105321129419701 -0.718161877117594 9.11526444419931e-09 MirTarget -0.141914780762832 0.000601857836063652 NA NA NA hsa-miR-19b-3p SLC25A37 0.601279551368824 0.00016685097085251 -0.718161877117594 9.11526444419931e-09 mirMAP -0.176430525841617 4.0309749220897e-06 NA NA NA hsa-miR-20a-5p SLC25A37 0.854326758727003 5.04256669663285e-07 -0.718161877117594 9.11526444419931e-09 mirMAP -0.17315361235863 1.18783290001245e-06 NA NA NA hsa-miR-455-5p SLC26A10 -0.270546034117157 0.0581320703577731 1.51576957133997 7.8768944563741e-10 miRanda -0.245552925728115 0.00437944726722261 NA NA NA hsa-miR-192-5p SLC26A2 -0.50188499512787 0.00344713341196035 1.09398018681738 4.62078215884211e-18 miRNAWalker2_validate -0.18929295889859 2.86751937479486e-07 NA NA NA hsa-miR-27b-3p SLC26A2 -0.823491817819754 9.20935302746823e-14 1.09398018681738 4.62078215884211e-18 MirTarget;mirMAP -0.217078303758547 0.000120093583037924 NA NA NA hsa-miR-455-3p SLC26A2 -1.3998033821095 5.72010709806871e-17 1.09398018681738 4.62078215884211e-18 MirTarget -0.193285071644833 1.16201246661156e-07 NA NA NA hsa-miR-19b-3p SLC26A7 0.601279551368824 0.00016685097085251 0.163358396010473 0.518493144754906 miRNATAP -0.220703987831556 0.00401837610372929 NA NA NA hsa-miR-34a-5p SLC26A9 1.03694231790865 5.74864019540594e-14 -0.222947281106455 0.517250441135712 MirTarget -0.52352127768129 8.01735693656588e-06 NA NA NA hsa-miR-30b-5p SLC29A3 -0.54056186708617 2.44688760798341e-05 -0.0667578295586497 0.523105108620896 MirTarget -0.112878227298197 0.00421513074091655 NA NA NA hsa-miR-30c-5p SLC29A3 -0.432111642767632 0.000159764714931007 -0.0667578295586497 0.523105108620896 MirTarget;miRNATAP -0.105669823013668 0.0173292603982489 NA NA NA hsa-miR-148a-3p SLC2A1 -0.748702855596996 3.93313343865641e-07 0.341472370166429 0.158776644395418 MirTarget;miRNATAP -0.348562751036544 9.14649062361368e-06 NA NA NA hsa-miR-17-3p SLC2A10 0.410352776142368 0.00422200500748636 -0.9546441634168 2.36808412411053e-05 miRNATAP -0.180088940303013 0.0202378780409293 NA NA NA hsa-miR-146b-5p SLC2A13 0.419719546795449 0.0457375823220155 -0.669417511857459 2.15685949976601e-05 mirMAP -0.127032078041566 0.000544612870551575 NA NA NA hsa-miR-34a-5p SLC2A13 1.03694231790865 5.74864019540594e-14 -0.669417511857459 2.15685949976601e-05 miRNATAP -0.430693631461288 3.01099771016782e-16 NA NA NA hsa-miR-455-5p SLC2A14 -0.270546034117157 0.0581320703577731 -0.522532636821002 0.0471213016678003 miRanda -0.201244133984809 0.0259073456683151 NA NA NA hsa-miR-148a-3p SLC2A3 -0.748702855596996 3.93313343865641e-07 -1.04127632515242 1.14147654600336e-07 miRNAWalker2_validate -0.190614379961144 0.00339947195751862 NA NA NA hsa-miR-15a-5p SLC2A3 0.349521211668244 0.000770735998804736 -1.04127632515242 1.14147654600336e-07 miRNATAP -0.247914523270874 0.00829963882412987 NA NA NA hsa-miR-194-5p SLC2A3 -0.292530160992458 0.0996141384876663 -1.04127632515242 1.14147654600336e-07 miRNATAP -0.304123447401868 1.74446736889436e-08 NA NA NA hsa-miR-20a-5p SLC2A3 0.854326758727003 5.04256669663285e-07 -1.04127632515242 1.14147654600336e-07 mirMAP -0.269088228510012 1.50616194401085e-06 NA NA NA hsa-miR-34a-5p SLC2A3 1.03694231790865 5.74864019540594e-14 -1.04127632515242 1.14147654600336e-07 miRNAWalker2_validate -0.146552870346614 0.032590298343565 NA NA NA hsa-miR-455-5p SLC2A3 -0.270546034117157 0.0581320703577731 -1.04127632515242 1.14147654600336e-07 miRanda -0.246606225053128 0.000287905404178997 NA NA NA hsa-miR-21-5p SLC30A10 1.51084295924322 1.54551622173259e-34 -0.0543453064095001 0.81132950410964 MirTarget -0.33819710274008 4.12133043822169e-05 NA NA NA hsa-miR-29c-3p SLC30A3 -1.4367517608807 1.61767774905781e-21 2.12377148785262 6.62978126874591e-08 miRNATAP -0.42337144053152 0.000557606335914182 NA NA NA hsa-miR-19b-3p SLC30A4 0.601279551368824 0.00016685097085251 -1.6297463081985 4.78960939907626e-09 mirMAP -0.318257848579265 0.000209887475891895 NA NA NA hsa-miR-30b-5p SLC30A4 -0.54056186708617 2.44688760798341e-05 -1.6297463081985 4.78960939907626e-09 mirMAP -0.423985997754927 7.42567859204022e-05 NA NA NA hsa-miR-409-3p SLC30A4 -0.499649792570937 0.0526751181520117 -1.6297463081985 4.78960939907626e-09 mirMAP -0.174269301852118 0.00110804873233658 NA NA NA hsa-miR-146b-5p SLC30A6 0.419719546795449 0.0457375823220155 -0.0189578644842108 0.883339104188036 miRanda -0.106162335084281 0.000360988301309962 NA NA NA hsa-miR-17-3p SLC30A7 0.410352776142368 0.00422200500748636 -0.168992150629458 0.0297751384329995 MirTarget -0.150180264640552 6.8334312972809e-09 NA NA NA hsa-miR-20a-5p SLC31A1 0.854326758727003 5.04256669663285e-07 -1.14463479413429 2.19129504521951e-22 mirMAP -0.142226517589456 4.62417018819386e-05 NA NA NA hsa-miR-21-5p SLC31A1 1.51084295924322 1.54551622173259e-34 -1.14463479413429 2.19129504521951e-22 miRNAWalker2_validate -0.495672539696826 2.26515771240959e-32 NA NA NA hsa-miR-19b-3p SLC31A2 0.601279551368824 0.00016685097085251 -1.16886067105462 2.12401692399079e-18 MirTarget -0.209199284096231 5.89597491692514e-07 NA NA NA hsa-miR-181b-5p SLC35A3 0.488256489401108 0.00105321129419701 -0.547853260400994 1.47231547250532e-05 mirMAP -0.342844443804445 1.06116211779551e-17 NA NA NA hsa-miR-20a-5p SLC35A3 0.854326758727003 5.04256669663285e-07 -0.547853260400994 1.47231547250532e-05 mirMAP -0.116258699262612 0.00125799273414361 NA NA NA hsa-miR-30b-5p SLC35A3 -0.54056186708617 2.44688760798341e-05 -0.547853260400994 1.47231547250532e-05 MirTarget -0.147035840851825 0.0023117530613048 NA NA NA hsa-miR-30b-5p SLC35A5 -0.54056186708617 2.44688760798341e-05 -0.432035691927913 6.38931855500987e-08 mirMAP -0.161210680871238 9.6679480741969e-08 NA NA NA hsa-miR-181a-5p SLC35B4 0.250113435902954 0.0551933249319293 0.122330329859142 0.249678861953627 miRNAWalker2_validate;mirMAP -0.258776014016107 2.83379704641187e-11 NA NA NA hsa-miR-181b-5p SLC35B4 0.488256489401108 0.00105321129419701 0.122330329859142 0.249678861953627 mirMAP -0.251940105869368 6.32976936802863e-14 NA NA NA hsa-miR-30b-5p SLC35B4 -0.54056186708617 2.44688760798341e-05 0.122330329859142 0.249678861953627 MirTarget -0.132417189874591 0.000947675999203635 NA NA NA hsa-miR-30e-5p SLC35C1 -0.627815042856657 3.02205690184908e-10 -0.305503742455431 0.0739389746796525 MirTarget -0.163362787854332 0.0484534042421256 NA NA NA hsa-miR-182-5p SLC35D1 1.96601340710222 4.39326175603633e-09 -1.52905192038684 6.67856673208906e-27 MirTarget -0.131709320614465 5.77214954326661e-10 NA NA NA hsa-miR-19b-3p SLC35D1 0.601279551368824 0.00016685097085251 -1.52905192038684 6.67856673208906e-27 miRNAWalker2_validate;MirTarget -0.113473371778668 0.0140101447475979 NA NA NA hsa-miR-192-3p SLC35F3 -0.6401165114007 0.000266272092403814 -0.462303983641436 0.153172594830782 MirTarget -0.470853315626633 9.66016813011108e-08 NA NA NA hsa-miR-192-5p SLC35F3 -0.50188499512787 0.00344713341196035 -0.462303983641436 0.153172594830782 miRNAWalker2_validate -0.547128220537391 1.28939029625719e-09 NA NA NA hsa-miR-194-5p SLC35F3 -0.292530160992458 0.0996141384876663 -0.462303983641436 0.153172594830782 miRNATAP -0.549176175618873 3.04448178894015e-10 NA NA NA hsa-miR-215-5p SLC35F3 -0.981544773246509 3.14452272477156e-05 -0.462303983641436 0.153172594830782 miRNAWalker2_validate -0.137950582234179 0.037750318153621 NA NA NA hsa-miR-15a-5p SLC35F5 0.349521211668244 0.000770735998804736 -0.347747668560416 0.000413266412082304 MirTarget -0.139139988601283 0.00275336233688472 NA NA NA hsa-miR-21-5p SLC35F5 1.51084295924322 1.54551622173259e-34 -0.347747668560416 0.000413266412082304 MirTarget -0.183358853918835 2.6404634334924e-07 NA NA NA hsa-miR-27b-3p SLC36A1 -0.823491817819754 9.20935302746823e-14 1.00108743458475 1.1038952891858e-17 mirMAP -0.327053304705245 1.96588203108573e-10 NA NA NA hsa-miR-30c-5p SLC36A1 -0.432111642767632 0.000159764714931007 1.00108743458475 1.1038952891858e-17 miRNATAP -0.120086648929465 0.0206642154996462 NA NA NA hsa-miR-222-3p SLC37A4 1.08574156066353 1.76407192348131e-11 -0.963308910959521 4.17930136908228e-11 miRNAWalker2_validate -0.284918864314112 3.99862497329826e-11 NA NA NA hsa-miR-181b-5p SLC38A11 0.488256489401108 0.00105321129419701 -0.145549128486136 0.574613575913413 MirTarget -0.179242563421328 0.0343258881566124 NA NA NA hsa-miR-181a-5p SLC38A2 0.250113435902954 0.0551933249319293 -1.71612155888541 1.01671436925464e-27 mirMAP;miRNATAP -0.352289694846823 1.48633247008317e-08 NA NA NA hsa-miR-181b-5p SLC38A2 0.488256489401108 0.00105321129419701 -1.71612155888541 1.01671436925464e-27 mirMAP;miRNATAP -0.363854669515172 1.20634773577144e-11 NA NA NA hsa-miR-182-5p SLC38A4 1.96601340710222 4.39326175603633e-09 -2.20440604206587 1.47282964888718e-12 miRNATAP -0.258887455556858 8.60936108412868e-09 NA NA NA hsa-miR-20a-5p SLC38A7 0.854326758727003 5.04256669663285e-07 0.104382958953614 0.530198765508847 mirMAP -0.117132603934739 0.0127942532299911 NA NA NA hsa-miR-30b-5p SLC38A7 -0.54056186708617 2.44688760798341e-05 0.104382958953614 0.530198765508847 MirTarget -0.221947082955509 0.000401484517848627 NA NA NA hsa-miR-30c-5p SLC39A1 -0.432111642767632 0.000159764714931007 0.676984930840535 1.23504219487475e-14 miRNAWalker2_validate -0.104690047704099 0.00657799519027616 NA NA NA hsa-miR-30e-5p SLC39A10 -0.627815042856657 3.02205690184908e-10 1.03363681046182 2.86152302488301e-10 mirMAP -0.329997347274629 4.12419140027079e-05 NA NA NA hsa-miR-148a-3p SLC39A13 -0.748702855596996 3.93313343865641e-07 0.702545531021421 5.82346425244418e-19 miRNATAP -0.222800867605752 6.15944021935761e-18 NA NA NA hsa-miR-27b-3p SLC39A13 -0.823491817819754 9.20935302746823e-14 0.702545531021421 5.82346425244418e-19 miRNATAP -0.12980897586579 0.00023476727009572 NA NA NA hsa-miR-20a-5p SLC39A14 0.854326758727003 5.04256669663285e-07 -1.85864021395129 3.32951300990533e-30 mirMAP -0.216461690158133 1.12426641584842e-05 NA NA NA hsa-miR-146b-5p SLC3A1 0.419719546795449 0.0457375823220155 -3.47176889198375 5.72181937883687e-13 miRanda -0.263059630746854 0.0223832087283929 NA NA NA hsa-miR-20a-5p SLC40A1 0.854326758727003 5.04256669663285e-07 -0.732233412510245 1.8108481356758e-08 miRNATAP -0.246179472239857 1.75567207064433e-11 NA NA NA hsa-miR-15a-5p SLC41A2 0.349521211668244 0.000770735998804736 -1.77892020784739 8.70104480681686e-18 MirTarget -0.566529081912377 1.58987528699179e-08 NA NA NA hsa-miR-148a-3p SLC45A4 -0.748702855596996 3.93313343865641e-07 1.20758734416733 6.6417314824029e-07 mirMAP -0.79388527746553 1.02781346364025e-25 NA NA NA hsa-miR-29c-3p SLC45A4 -1.4367517608807 1.61767774905781e-21 1.20758734416733 6.6417314824029e-07 mirMAP -0.384664744537088 2.80627171942128e-07 NA NA NA hsa-miR-455-3p SLC45A4 -1.3998033821095 5.72010709806871e-17 1.20758734416733 6.6417314824029e-07 mirMAP -0.36153445301039 1.1603585677171e-07 NA NA NA hsa-miR-505-5p SLC45A4 -0.768282569967001 1.14662846595407e-05 1.20758734416733 6.6417314824029e-07 mirMAP -0.28630995182027 2.21891589458103e-05 NA NA NA hsa-miR-20a-5p SLC46A3 0.854326758727003 5.04256669663285e-07 -2.30736008231442 6.1076171377924e-15 MirTarget -0.627945552818981 9.42496618319929e-14 NA NA NA hsa-miR-20b-5p SLC46A3 0.457668023910379 0.0285865211936156 -2.30736008231442 6.1076171377924e-15 MirTarget -0.146873268667011 0.0397599744949141 NA NA NA hsa-miR-455-5p SLC46A3 -0.270546034117157 0.0581320703577731 -2.30736008231442 6.1076171377924e-15 miRanda -0.257486759273818 0.0141235643698125 NA NA NA hsa-miR-15a-5p SLC4A4 0.349521211668244 0.000770735998804736 -2.23317622565422 7.81779722860372e-13 MirTarget;miRNATAP -0.798962116628677 8.68979568903402e-08 NA NA NA hsa-miR-181a-5p SLC4A4 0.250113435902954 0.0551933249319293 -2.23317622565422 7.81779722860372e-13 mirMAP -0.758693229830471 1.29353731633459e-10 NA NA NA hsa-miR-181b-5p SLC4A4 0.488256489401108 0.00105321129419701 -2.23317622565422 7.81779722860372e-13 mirMAP -0.804332139642516 2.11703095887466e-15 NA NA NA hsa-miR-182-5p SLC4A4 1.96601340710222 4.39326175603633e-09 -2.23317622565422 7.81779722860372e-13 mirMAP -0.19434652639763 1.89432765311187e-05 NA NA NA hsa-miR-20a-5p SLC4A4 0.854326758727003 5.04256669663285e-07 -2.23317622565422 7.81779722860372e-13 MirTarget -0.822836909023111 2.0355655458646e-21 NA NA NA hsa-miR-20b-5p SLC4A4 0.457668023910379 0.0285865211936156 -2.23317622565422 7.81779722860372e-13 MirTarget -0.277959151879267 0.000188197566204632 NA NA NA hsa-miR-221-3p SLC4A4 1.12244756358612 3.48370308238012e-13 -2.23317622565422 7.81779722860372e-13 miRNATAP -0.784979956472366 1.6201625395874e-16 NA NA NA hsa-miR-222-3p SLC4A4 1.08574156066353 1.76407192348131e-11 -2.23317622565422 7.81779722860372e-13 miRNATAP -0.738080936605192 7.15725792666426e-16 NA NA NA hsa-miR-432-5p SLC4A4 -0.536178819038888 0.0748623258271085 -2.23317622565422 7.81779722860372e-13 MirTarget -0.227132726005885 1.12013653877449e-05 NA NA NA hsa-miR-34a-5p SLC4A7 1.03694231790865 5.74864019540594e-14 -0.103567361149529 0.538348902217845 miRNAWalker2_validate;MirTarget;miRNATAP -0.218527373628711 0.000142720567043023 NA NA NA hsa-miR-30c-5p SLC5A11 -0.432111642767632 0.000159764714931007 1.33074236992381 0.00169764241929042 miRNATAP -0.433445125273436 0.0170527397034658 NA NA NA hsa-miR-30e-5p SLC5A11 -0.627815042856657 3.02205690184908e-10 1.33074236992381 0.00169764241929042 miRNATAP -0.600688510901237 0.003509987539213 NA NA NA hsa-miR-181a-5p SLC5A3 0.250113435902954 0.0551933249319293 -1.14202730091157 9.93875965261116e-13 mirMAP -0.12486103603245 0.0437412700623721 NA NA NA hsa-miR-181b-5p SLC5A3 0.488256489401108 0.00105321129419701 -1.14202730091157 9.93875965261116e-13 mirMAP -0.110059111313844 0.040998732942814 NA NA NA hsa-miR-194-5p SLC5A3 -0.292530160992458 0.0996141384876663 -1.14202730091157 9.93875965261116e-13 mirMAP -0.102414175475055 0.0237562136668521 NA NA NA hsa-miR-21-5p SLC5A3 1.51084295924322 1.54551622173259e-34 -1.14202730091157 9.93875965261116e-13 miRNAWalker2_validate -0.537351225066056 6.71065741144818e-21 NA NA NA hsa-miR-221-3p SLC5A3 1.12244756358612 3.48370308238012e-13 -1.14202730091157 9.93875965261116e-13 mirMAP -0.143811301491153 0.00447982622806733 NA NA NA hsa-miR-27b-3p SLC5A6 -0.823491817819754 9.20935302746823e-14 0.197307436899311 0.230852494089565 miRNAWalker2_validate -0.141925936029322 0.0455898319731579 NA NA NA hsa-miR-132-3p SLC6A1 0.323796239695997 0.00272093067935091 -1.17614916548093 6.73017890737053e-05 MirTarget;miRNATAP -1.17105881413753 1.16821012445279e-19 NA NA NA hsa-miR-455-5p SLC6A15 -0.270546034117157 0.0581320703577731 0.497584853225585 0.14038466590646 miRanda -0.242937812651357 0.0358762099187372 NA NA NA hsa-miR-192-3p SLC6A6 -0.6401165114007 0.000266272092403814 -0.096527667226542 0.716815862195345 mirMAP -0.64703432744178 2.80817326260588e-20 NA NA NA hsa-miR-27b-3p SLC6A6 -0.823491817819754 9.20935302746823e-14 -0.096527667226542 0.716815862195345 miRNATAP -0.454973244535813 6.50136825790604e-05 NA NA NA hsa-miR-34a-5p SLC6A6 1.03694231790865 5.74864019540594e-14 -0.096527667226542 0.716815862195345 MirTarget -0.249151390073058 0.00634433750849245 NA NA NA hsa-miR-455-5p SLC6A6 -0.270546034117157 0.0581320703577731 -0.096527667226542 0.716815862195345 mirMAP -0.591967122738217 2.95277507475079e-11 NA NA NA hsa-miR-30e-5p SLC6A9 -0.627815042856657 3.02205690184908e-10 1.60171675413333 2.53615434866147e-10 MirTarget -0.47937029298261 0.000119514775900116 NA NA NA hsa-miR-192-3p SLC7A1 -0.6401165114007 0.000266272092403814 0.502718713769507 0.0648822874814592 mirMAP -0.603933078701213 8.6699311123384e-17 NA NA NA hsa-miR-192-5p SLC7A1 -0.50188499512787 0.00344713341196035 0.502718713769507 0.0648822874814592 mirMAP -0.603441045872077 6.26149464563179e-16 NA NA NA hsa-miR-34a-5p SLC7A1 1.03694231790865 5.74864019540594e-14 0.502718713769507 0.0648822874814592 mirMAP -0.368806781458608 7.49649115735741e-05 NA NA NA hsa-miR-148a-3p SLC7A11 -0.748702855596996 3.93313343865641e-07 3.47167805920945 1.56674476751757e-19 miRNATAP -0.536459394778507 4.08618619144432e-05 NA NA NA hsa-miR-192-5p SLC7A11 -0.50188499512787 0.00344713341196035 3.47167805920945 1.56674476751757e-19 miRNAWalker2_validate;mirMAP -0.504382504388114 8.44260569578369e-06 NA NA NA hsa-miR-215-5p SLC7A11 -0.981544773246509 3.14452272477156e-05 3.47167805920945 1.56674476751757e-19 miRNAWalker2_validate -0.39067616995676 1.71852109358467e-06 NA NA NA hsa-miR-27b-3p SLC7A11 -0.823491817819754 9.20935302746823e-14 3.47167805920945 1.56674476751757e-19 miRNATAP -1.16619265566671 5.68697337740727e-12 NA NA NA hsa-miR-30c-5p SLC7A11 -0.432111642767632 0.000159764714931007 3.47167805920945 1.56674476751757e-19 mirMAP;miRNATAP -0.473837154572096 0.00571463307469318 NA NA NA hsa-miR-30e-5p SLC7A11 -0.627815042856657 3.02205690184908e-10 3.47167805920945 1.56674476751757e-19 mirMAP -1.08197789823018 1.66502724295e-08 NA NA NA hsa-miR-182-5p SLC7A14 1.96601340710222 4.39326175603633e-09 0.111640486716036 0.761457908255693 MirTarget -0.11879327463588 0.0234597787270653 NA NA NA hsa-miR-15a-5p SLC7A2 0.349521211668244 0.000770735998804736 -2.401238445104 3.47302530727145e-22 MirTarget;miRNATAP -0.510936235691793 3.02685650376086e-05 NA NA NA hsa-miR-181a-5p SLC7A2 0.250113435902954 0.0551933249319293 -2.401238445104 3.47302530727145e-22 MirTarget -0.388697605177306 6.89542530827914e-05 NA NA NA hsa-miR-181b-5p SLC7A2 0.488256489401108 0.00105321129419701 -2.401238445104 3.47302530727145e-22 MirTarget -0.344476706283616 4.98763727551343e-05 NA NA NA hsa-miR-34a-5p SLC7A2 1.03694231790865 5.74864019540594e-14 -2.401238445104 3.47302530727145e-22 miRNATAP -0.55897443706263 2.22804176795081e-10 NA NA NA hsa-miR-194-5p SLC7A5 -0.292530160992458 0.0996141384876663 -0.136370123412726 0.551559001435635 MirTarget -0.255790940628273 4.24011190612921e-05 NA NA NA hsa-miR-455-3p SLC7A5 -1.3998033821095 5.72010709806871e-17 -0.136370123412726 0.551559001435635 mirMAP -0.153329166013508 0.0170035001411926 NA NA NA hsa-miR-194-5p SLC7A6 -0.292530160992458 0.0996141384876663 1.05415038736953 3.23595493046086e-20 MirTarget -0.215694535821097 2.12236765779388e-11 NA NA NA hsa-miR-29c-3p SLC7A6 -1.4367517608807 1.61767774905781e-21 1.05415038736953 3.23595493046086e-20 MirTarget -0.131193298124674 0.000360514934669197 NA NA NA hsa-miR-30c-5p SLC7A6 -0.432111642767632 0.000159764714931007 1.05415038736953 3.23595493046086e-20 mirMAP -0.16569134332062 0.00115238471042738 NA NA NA hsa-miR-30e-5p SLC7A6 -0.627815042856657 3.02205690184908e-10 1.05415038736953 3.23595493046086e-20 mirMAP -0.359787690280588 2.42561513652084e-10 NA NA NA hsa-miR-148a-3p SLC8A1 -0.748702855596996 3.93313343865641e-07 -1.67234164835265 3.98185932744172e-20 MirTarget -0.196962024419765 0.00156195195265746 NA NA NA hsa-miR-19b-3p SLC8A1 0.601279551368824 0.00016685097085251 -1.67234164835265 3.98185932744172e-20 MirTarget -0.300897929684346 1.50413638131271e-07 NA NA NA hsa-miR-455-5p SLC8A1 -0.270546034117157 0.0581320703577731 -1.67234164835265 3.98185932744172e-20 miRanda -0.361057986771592 2.09924485019981e-08 NA NA NA hsa-miR-19b-3p SLC9A1 0.601279551368824 0.00016685097085251 0.165675299240051 0.168213985657365 MirTarget -0.143715272914156 7.37473806940187e-05 NA NA NA hsa-miR-181a-5p SLC9A6 0.250113435902954 0.0551933249319293 0.354720189606656 3.82887675091218e-05 miRNATAP -0.162913511401398 3.9192471508885e-07 NA NA NA hsa-miR-181b-5p SLC9A6 0.488256489401108 0.00105321129419701 0.354720189606656 3.82887675091218e-05 miRNATAP -0.133438886851361 1.85957769801553e-06 NA NA NA hsa-miR-19b-3p SLC9A6 0.601279551368824 0.00016685097085251 0.354720189606656 3.82887675091218e-05 MirTarget;miRNATAP -0.109044740688381 2.98925975789119e-05 NA NA NA hsa-miR-17-3p SLC9A7 0.410352776142368 0.00422200500748636 -0.844830400025242 6.21698408454966e-05 miRNATAP -0.340056011498594 2.06115026134904e-06 NA NA NA hsa-miR-182-5p SLCO1A2 1.96601340710222 4.39326175603633e-09 -1.53455538662681 4.79106917340698e-05 mirMAP -0.257376150507884 1.69210958313293e-06 NA NA NA hsa-miR-182-5p SLCO2B1 1.96601340710222 4.39326175603633e-09 -1.48136466043352 8.30231025172681e-13 MirTarget -0.185826970606698 4.46146569649033e-10 NA NA NA hsa-miR-146b-5p SLCO3A1 0.419719546795449 0.0457375823220155 0.0319186627851762 0.855727741201124 MirTarget;miRanda;miRNATAP -0.104039305939693 0.0104531473070921 NA NA NA hsa-miR-192-5p SLCO3A1 -0.50188499512787 0.00344713341196035 0.0319186627851762 0.855727741201124 miRNAWalker2_validate -0.393469014234583 2.23727777917774e-16 NA NA NA hsa-miR-34a-5p SLCO3A1 1.03694231790865 5.74864019540594e-14 0.0319186627851762 0.855727741201124 MirTarget;miRNATAP -0.137716118932732 0.0222752603867033 NA NA NA hsa-miR-27b-3p SLCO5A1 -0.823491817819754 9.20935302746823e-14 0.673563110902495 0.0153869463632922 MirTarget -0.542278204145694 5.25045832598219e-06 NA NA NA hsa-miR-30b-5p SLCO6A1 -0.54056186708617 2.44688760798341e-05 0.952306714055347 0.00411140749882226 MirTarget -0.363767526335244 0.00394243137794508 NA NA NA hsa-miR-432-5p SLCO6A1 -0.536178819038888 0.0748623258271085 0.952306714055347 0.00411140749882226 MirTarget -0.11823043321032 0.0289790347198245 NA NA NA hsa-miR-194-5p SLFN13 -0.292530160992458 0.0996141384876663 -0.628307489692556 0.0402974016169269 mirMAP -0.607851745445433 1.17439404301477e-13 NA NA NA hsa-miR-17-3p SLFN5 0.410352776142368 0.00422200500748636 -0.551587674528743 0.0044566272451042 mirMAP -0.392396491903226 1.56495782577367e-09 NA NA NA hsa-miR-192-3p SLFN5 -0.6401165114007 0.000266272092403814 -0.551587674528743 0.0044566272451042 mirMAP -0.116137136390171 0.0309565125259725 NA NA NA hsa-miR-20a-5p SLFN5 0.854326758727003 5.04256669663285e-07 -0.551587674528743 0.0044566272451042 mirMAP -0.403161741335862 4.97863429587109e-14 NA NA NA hsa-miR-20b-5p SLFN5 0.457668023910379 0.0285865211936156 -0.551587674528743 0.0044566272451042 mirMAP -0.145833839695726 0.0012583357788685 NA NA NA hsa-miR-27b-3p SLFN5 -0.823491817819754 9.20935302746823e-14 -0.551587674528743 0.0044566272451042 MirTarget -0.301425496157525 0.000307786052888751 NA NA NA hsa-miR-192-5p SLIT3 -0.50188499512787 0.00344713341196035 0.157466553388729 0.504736595264199 mirMAP -0.470658969765089 4.74981152368516e-13 NA NA NA hsa-miR-20a-5p SLITRK3 0.854326758727003 5.04256669663285e-07 -5.61860150003464 8.77286424520162e-28 miRNATAP -0.344476787536725 0.0275112446726135 NA NA NA hsa-miR-224-3p SLITRK3 1.40770116795301 1.31426607144612e-08 -5.61860150003464 8.77286424520162e-28 MirTarget -0.264885898329724 0.0141242988485984 NA NA NA hsa-miR-19b-3p SLITRK6 0.601279551368824 0.00016685097085251 -4.32481280312425 1.81848292071194e-42 miRNATAP -0.233290633786528 0.0294239629560723 NA NA NA hsa-miR-20a-5p SLK 0.854326758727003 5.04256669663285e-07 -0.352886234776743 0.000875676142405013 MirTarget -0.100483399287651 0.000825494029384894 NA NA NA hsa-miR-21-5p SLK 1.51084295924322 1.54551622173259e-34 -0.352886234776743 0.000875676142405013 miRNAWalker2_validate -0.159745655335613 3.43594750142475e-05 NA NA NA hsa-miR-146a-5p SLPI -0.742958238440575 0.000765983177482633 -1.2690886082659 0.0132718919506929 miRNAWalker2_validate -0.243140120389448 0.0314166747377826 NA NA NA hsa-miR-455-5p SMAD2 -0.270546034117157 0.0581320703577731 0.315604980822302 9.76507196938151e-07 miRanda -0.126014730396316 7.82261975485323e-09 NA NA NA hsa-miR-34a-5p SMAD4 1.03694231790865 5.74864019540594e-14 -0.30976054630181 7.55983294717014e-05 miRNATAP -0.106481148933391 7.14459232465546e-05 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-148a-3p SMAD5 -0.748702855596996 3.93313343865641e-07 0.163025158576987 0.0964365530955469 MirTarget -0.118682964369505 0.000191401765007103 NA NA NA hsa-miR-20a-5p SMAD7 0.854326758727003 5.04256669663285e-07 -0.723856409040082 1.50332971335389e-07 miRNATAP -0.116628969266854 0.00318831344924215 NA NA NA hsa-miR-21-5p SMAD7 1.51084295924322 1.54551622173259e-34 -0.723856409040082 1.50332971335389e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.273576086802476 5.38840691437798e-08 23372687;27185036;26531758 Furthermore the expression of MSH2 and SMAD7 two important molecules involving TGF-β pathway was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells;MicroRNA 21 Regulates Non Small Cell Lung Cancer Cell Invasion and Chemo Sensitivity through SMAD7; We performed bioinformatics analyses on the binding of microRNA-21 miR-21 to the 3'-UTR of SMAD7 mRNA and verified the biological effects of this binding using promoter luciferase reporter assay; Furthermore expression of miR-21 was found to be inhibited by Carboplatin and bioinformatics analyses showed that miR-21 targeted the 3'-UTR of SMAD7 mRNA to inhibit its translation which was confirmed by luciferase reporter assay; Carboplatin may upregulate SMAD7 through suppression of miR-21 to inhibit TGFβ receptor signaling mediated NSCLC cell invasion;MicroRNA 21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF β pathways; The present study was undertaken to determine the association of miR-21 smad7 EGF and TGF-β with breast cancer cell invasion and migration and to identify the molecular mechanisms involved using immunohistochemistry and western blot analysis; Smad7 was confirmed to be a direct target of miR-21 by luciferase reporter and western blot assays; The downregulation of smad7 by miR-21 or sismad7 enhanced EGF-dependent invasion and migration as well as TGF-β-dependent invasion and migration; The actions of miR-21 were abrogated by expressing a modified smad7 cDNA resistant to miR-21; In conclusion our results demonstrated that plasma miR-21 levels may serve as a diagnostic marker in breast cancers whereas miR-21 promotes breast cancer cell proliferation and invasion by suppressing smad7 which enhances EGF and TGF-β pathways ;; breast cancer;lung squamous cell cancer;breast cancer hsa-miR-34a-5p SMAD7 1.03694231790865 5.74864019540594e-14 -0.723856409040082 1.50332971335389e-07 MirTarget -0.188822980243553 7.67367411949942e-05 NA NA NA hsa-miR-20a-5p SMAD9 0.854326758727003 5.04256669663285e-07 -1.49767600167527 1.61311444052049e-07 mirMAP -0.324007275940665 7.46808100744451e-05 NA NA NA hsa-miR-455-5p SMAD9 -0.270546034117157 0.0581320703577731 -1.49767600167527 1.61311444052049e-07 MirTarget -0.205763141909193 0.0387283552319808 NA NA NA hsa-miR-505-5p SMAGP -0.768282569967001 1.14662846595407e-05 0.543675729429215 0.000383375037866114 miRNATAP -0.174913305642671 3.42878546742796e-05 NA NA NA hsa-miR-30b-5p SMAP2 -0.54056186708617 2.44688760798341e-05 -0.298341993548512 0.000285394286708245 miRNATAP -0.103968418064404 0.000842791791935411 NA NA NA hsa-miR-19b-3p SMARCA2 0.601279551368824 0.00016685097085251 -1.06583426873391 1.91446120660579e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.30687136768134 3.1502676582779e-11 NA NA NA hsa-miR-455-5p SMARCAD1 -0.270546034117157 0.0581320703577731 -0.353533465180224 0.00291654870575874 miRanda -0.178661500662031 1.00091070046705e-05 NA NA NA hsa-miR-29c-3p SMARCC1 -1.4367517608807 1.61767774905781e-21 0.453331771984192 2.34444535272705e-08 miRNATAP -0.233856152160327 2.13201159340804e-22 NA NA NA hsa-miR-148a-3p SMARCD1 -0.748702855596996 3.93313343865641e-07 0.643238619401545 1.43047276243426e-17 miRNATAP -0.179723038421978 4.85357530537153e-13 NA NA NA hsa-miR-181a-5p SMC1A 0.250113435902954 0.0551933249319293 0.0651833474337025 0.510370716253497 mirMAP -0.117542893899761 0.00146146139664929 NA NA NA hsa-miR-27b-3p SMCR8 -0.823491817819754 9.20935302746823e-14 0.453242799658724 3.50739679214307e-06 MirTarget -0.113122241716497 0.00769664924976443 NA NA NA hsa-miR-192-3p SMOC2 -0.6401165114007 0.000266272092403814 0.521075880519206 0.0476139845164226 mirMAP -0.296331079637402 4.18715693548693e-05 NA NA NA hsa-miR-15a-5p SMPD1 0.349521211668244 0.000770735998804736 -0.735905559536108 1.70137749459267e-11 MirTarget -0.209346192708317 6.55637577520556e-05 NA NA NA hsa-miR-20a-5p SMPD3 0.854326758727003 5.04256669663285e-07 -2.39946548240761 3.072395130044e-30 mirMAP -0.324689002767827 2.98851069807802e-07 NA NA NA hsa-miR-34a-5p SMPD3 1.03694231790865 5.74864019540594e-14 -2.39946548240761 3.072395130044e-30 mirMAP -0.304282142680891 8.30067139702774e-05 NA NA NA hsa-miR-148a-3p SMS -0.748702855596996 3.93313343865641e-07 0.164928667940139 0.0543736469004317 MirTarget;miRNATAP -0.129001086204858 3.12204121587798e-06 NA NA NA hsa-miR-29c-3p SMS -1.4367517608807 1.61767774905781e-21 0.164928667940139 0.0543736469004317 MirTarget -0.102854581671465 8.42478360865857e-05 NA NA NA hsa-miR-15a-5p SMURF1 0.349521211668244 0.000770735998804736 0.41243843797877 9.91971647783317e-06 MirTarget;miRNATAP -0.126773466642466 0.00415872019676827 NA NA NA hsa-miR-122-3p SMURF2 -1.75369011054591 1.52070648599898e-11 0.344618067830604 0.00268296348226083 MirTarget -0.140629048371772 7.54837110364061e-12 NA NA NA hsa-miR-30e-5p SNAI1 -0.627815042856657 3.02205690184908e-10 -1.12154757133066 1.27086429254762e-06 miRTarBase -0.276135653753563 0.0148865185848428 NA NA NA hsa-miR-181a-5p SNAI2 0.250113435902954 0.0551933249319293 0.384447886331124 0.102927984369101 miRNAWalker2_validate -0.261350612158367 0.00311299103180595 NA NA NA hsa-miR-182-5p SNAI2 1.96601340710222 4.39326175603633e-09 0.384447886331124 0.102927984369101 miRNAWalker2_validate;miRNATAP -0.103835953273872 0.00197162374541916 NA NA NA hsa-miR-34a-5p SNAP25 1.03694231790865 5.74864019540594e-14 -0.0700982369377097 0.862359285781652 miRNATAP -0.33703020242958 0.0152117605149681 NA NA NA hsa-miR-21-5p SNED1 1.51084295924322 1.54551622173259e-34 -0.697753140844763 1.06949754459612e-05 miRNATAP -0.573975270011572 1.6651715194934e-25 NA NA NA hsa-miR-148a-3p SNN -0.748702855596996 3.93313343865641e-07 0.139978056935726 0.1435877993436 MirTarget;miRNATAP -0.188024868908952 7.9924616995449e-10 NA NA NA hsa-miR-27b-3p SNN -0.823491817819754 9.20935302746823e-14 0.139978056935726 0.1435877993436 miRNATAP -0.255878709032127 2.1289737903032e-10 NA NA NA hsa-miR-148a-3p SNPH -0.748702855596996 3.93313343865641e-07 0.669218523436135 0.00151404681785838 mirMAP;miRNATAP -0.61217632083124 2.03479411590929e-20 NA NA NA hsa-miR-15a-5p SNRK 0.349521211668244 0.000770735998804736 -0.85262800892875 3.46352510534433e-18 MirTarget;miRNATAP -0.106445859201213 0.0270650590594742 NA NA NA hsa-miR-21-5p SNRK 1.51084295924322 1.54551622173259e-34 -0.85262800892875 3.46352510534433e-18 miRNAWalker2_validate -0.413281409472092 2.81445266762145e-33 NA NA NA hsa-miR-30b-5p SNRNP200 -0.54056186708617 2.44688760798341e-05 0.221628916933664 0.00174310307664295 miRNAWalker2_validate -0.12724425557033 1.59733140018078e-06 NA NA NA hsa-miR-148a-3p SNRPD1 -0.748702855596996 3.93313343865641e-07 0.672324466321794 7.13760714023798e-11 MirTarget -0.193675346146832 1.11177175064211e-08 NA NA NA hsa-miR-30c-5p SNRPD1 -0.432111642767632 0.000159764714931007 0.672324466321794 7.13760714023798e-11 mirMAP -0.187107414920635 2.73106153314161e-05 NA NA NA hsa-miR-30e-5p SNRPD1 -0.627815042856657 3.02205690184908e-10 0.672324466321794 7.13760714023798e-11 mirMAP -0.346115531557073 3.24990022613676e-12 NA NA NA hsa-miR-20a-5p SNTB2 0.854326758727003 5.04256669663285e-07 0.0360555273255536 0.678102231349933 miRNATAP -0.12323767013989 3.53516042068765e-07 NA NA NA hsa-miR-505-5p SNURF -0.768282569967001 1.14662846595407e-05 1.04125905379264 0.00965854407144642 MirTarget -0.260124331800562 0.0196526438998705 NA NA NA hsa-miR-181b-5p SNX1 0.488256489401108 0.00105321129419701 -0.199729686068656 0.00561090290533367 mirMAP -0.117503478896254 4.11444800763771e-07 NA NA NA hsa-miR-21-5p SNX1 1.51084295924322 1.54551622173259e-34 -0.199729686068656 0.00561090290533367 mirMAP -0.148423358085664 9.057605348543e-09 NA NA NA hsa-miR-20a-5p SNX12 0.854326758727003 5.04256669663285e-07 0.0904979691922572 0.516171836726953 miRNATAP -0.113338963700175 0.00398916157096421 NA NA NA hsa-miR-181a-5p SNX13 0.250113435902954 0.0551933249319293 -0.0282083258368075 0.737378753244596 mirMAP -0.112005422966252 0.000341965772633031 NA NA NA hsa-miR-19b-3p SNX20 0.601279551368824 0.00016685097085251 -0.491906068147153 0.0246568268123821 mirMAP -0.137473247237385 0.0393648606449832 NA NA NA hsa-miR-455-5p SNX24 -0.270546034117157 0.0581320703577731 0.159737088213358 0.0669375239820306 miRanda -0.124955437134735 2.35836989685423e-05 NA NA NA hsa-miR-30c-5p SNX27 -0.432111642767632 0.000159764714931007 0.701282370576235 4.48665293424922e-15 miRNATAP -0.105585154012019 0.00723456243640075 NA NA NA hsa-miR-194-5p SNX29 -0.292530160992458 0.0996141384876663 0.177502300758066 0.109329607346926 miRNATAP -0.241905555637489 1.53529528291239e-16 NA NA NA hsa-miR-29c-3p SNX30 -1.4367517608807 1.61767774905781e-21 0.0514003764836284 0.625541828460129 mirMAP -0.193174076742971 1.12482076236884e-09 NA NA NA hsa-miR-221-3p SNX4 1.12244756358612 3.48370308238012e-13 -0.536100687729702 1.28915337553997e-11 MirTarget -0.149748699874215 8.48339420719281e-10 NA NA NA hsa-miR-222-3p SNX4 1.08574156066353 1.76407192348131e-11 -0.536100687729702 1.28915337553997e-11 MirTarget -0.14936285555785 1.65959425736022e-10 NA NA NA hsa-miR-192-5p SOAT1 -0.50188499512787 0.00344713341196035 -0.0648381834249045 0.544577902932084 miRNAWalker2_validate -0.103656790977631 0.00058268637465778 NA NA NA hsa-miR-19b-3p SOCS2 0.601279551368824 0.00016685097085251 -2.6066749255576 8.74860477027169e-27 mirMAP -0.316467742568874 5.53737631720871e-05 NA NA NA hsa-miR-455-5p SOCS3 -0.270546034117157 0.0581320703577731 -2.30554269388213 1.3157298468501e-20 miRanda -0.360992723185637 4.63952771606627e-05 NA NA NA hsa-miR-455-5p SOCS4 -0.270546034117157 0.0581320703577731 -0.00799562822546118 0.920721716920263 miRanda -0.111227426429981 4.24940276023263e-05 NA NA NA hsa-miR-19b-3p SOCS6 0.601279551368824 0.00016685097085251 -1.07676840516879 9.71590997834803e-26 miRNATAP -0.107122453185057 0.00119378608361023 NA NA NA hsa-miR-20a-5p SOCS6 0.854326758727003 5.04256669663285e-07 -1.07676840516879 9.71590997834803e-26 miRNATAP -0.120227868735618 9.20661478497345e-05 NA NA NA hsa-miR-455-3p SOCS7 -1.3998033821095 5.72010709806871e-17 1.23630045260618 2.28814323600538e-14 miRNATAP -0.241140869300095 2.01109582124001e-07 NA NA NA hsa-miR-17-3p SOD2 0.410352776142368 0.00422200500748636 -0.690525669767364 9.88917819083763e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.197554038440491 0.00111333694742762 NA NA NA hsa-miR-221-3p SOD2 1.12244756358612 3.48370308238012e-13 -0.690525669767364 9.88917819083763e-05 MirTarget -0.307899581648328 1.25664929027329e-08 NA NA NA hsa-miR-222-3p SOD2 1.08574156066353 1.76407192348131e-11 -0.690525669767364 9.88917819083763e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.226729584532166 1.47155587285839e-05 NA NA NA hsa-miR-15a-5p SON 0.349521211668244 0.000770735998804736 -0.233972570797529 0.00322873559340571 miRNATAP -0.155502163209761 2.82842327853541e-05 NA NA NA hsa-miR-20a-5p SORBS2 0.854326758727003 5.04256669663285e-07 -1.05178871500438 1.28000308624213e-08 MirTarget -0.219491129300999 3.43262005500774e-05 NA NA NA hsa-miR-20b-5p SORBS2 0.457668023910379 0.0285865211936156 -1.05178871500438 1.28000308624213e-08 MirTarget -0.198319488265283 5.0167045238659e-06 NA NA NA hsa-miR-182-5p SORD 1.96601340710222 4.39326175603633e-09 -1.54687361507914 1.11505490567833e-12 mirMAP -0.251443673244012 3.06163055364109e-16 NA NA NA hsa-miR-19b-3p SORL1 0.601279551368824 0.00016685097085251 -1.76063037333749 3.20297520312196e-18 miRNATAP -0.228285966358851 0.000355745541439127 NA NA NA hsa-miR-20a-5p SORL1 0.854326758727003 5.04256669663285e-07 -1.76063037333749 3.20297520312196e-18 MirTarget;miRNATAP -0.28072917745071 2.18417619752167e-06 NA NA NA hsa-miR-20b-5p SORL1 0.457668023910379 0.0285865211936156 -1.76063037333749 3.20297520312196e-18 MirTarget;miRNATAP -0.183026437047721 0.000185829615826412 NA NA NA hsa-miR-505-5p SORT1 -0.768282569967001 1.14662846595407e-05 1.57067773298731 3.50162512345112e-17 MirTarget -0.116138087524185 0.0302997466965479 NA NA NA hsa-miR-20a-5p SOS1 0.854326758727003 5.04256669663285e-07 0.05751534180893 0.493041822065916 MirTarget;miRNATAP -0.100063123806167 2.02695724421345e-05 NA NA NA hsa-miR-30b-5p SOS1 -0.54056186708617 2.44688760798341e-05 0.05751534180893 0.493041822065916 mirMAP -0.125950231468023 6.21375879766061e-05 NA NA NA hsa-miR-146b-5p SOS2 0.419719546795449 0.0457375823220155 -0.326258424146275 0.000900714126323724 miRanda -0.110125845201631 1.10330856080798e-06 NA NA NA hsa-miR-21-5p SOS2 1.51084295924322 1.54551622173259e-34 -0.326258424146275 0.000900714126323724 miRNATAP -0.279899776012046 7.56477883436428e-16 NA NA NA hsa-miR-148a-3p SOX11 -0.748702855596996 3.93313343865641e-07 1.40787252269122 1.13853242912301e-05 miRNATAP -1.07091287526546 4.31008991786723e-27 NA NA NA hsa-miR-27b-3p SOX11 -0.823491817819754 9.20935302746823e-14 1.40787252269122 1.13853242912301e-05 miRNATAP -0.478067565459517 0.000596745384087221 NA NA NA hsa-miR-30e-5p SOX11 -0.627815042856657 3.02205690184908e-10 1.40787252269122 1.13853242912301e-05 mirMAP -0.642050185725221 3.74531692809174e-05 NA NA NA hsa-miR-455-5p SOX11 -0.270546034117157 0.0581320703577731 1.40787252269122 1.13853242912301e-05 PITA;miRanda;miRNATAP -0.305771688393231 0.00585183783644695 NA NA NA hsa-miR-29c-3p SOX12 -1.4367517608807 1.61767774905781e-21 1.13902221223852 8.89966671522395e-12 MirTarget;miRNATAP -0.519073066864083 1.36163327159808e-25 NA NA NA hsa-miR-30b-5p SOX12 -0.54056186708617 2.44688760798341e-05 1.13902221223852 8.89966671522395e-12 mirMAP -0.181302254703861 0.00520228946071506 NA NA NA hsa-miR-455-3p SOX12 -1.3998033821095 5.72010709806871e-17 1.13902221223852 8.89966671522395e-12 miRNATAP -0.111040352085672 0.0209888816267784 NA NA NA hsa-miR-34a-5p SOX4 1.03694231790865 5.74864019540594e-14 0.747197754187451 0.00273773360761816 miRNATAP -0.186182321617248 0.030671180058841 NA NA NA hsa-miR-132-3p SOX5 0.323796239695997 0.00272093067935091 -1.35870465626211 3.34572839723252e-09 MirTarget;miRNATAP -0.427259541658242 5.24157912472019e-05 NA NA NA hsa-miR-181a-5p SOX5 0.250113435902954 0.0551933249319293 -1.35870465626211 3.34572839723252e-09 miRNATAP -0.283679615205146 0.00122335290532398 NA NA NA hsa-miR-181b-5p SOX5 0.488256489401108 0.00105321129419701 -1.35870465626211 3.34572839723252e-09 miRNATAP -0.327867585217995 1.58088921796821e-05 NA NA NA hsa-miR-182-5p SOX5 1.96601340710222 4.39326175603633e-09 -1.35870465626211 3.34572839723252e-09 miRNATAP -0.158904197068443 1.54477504817868e-06 NA NA NA hsa-miR-21-5p SOX5 1.51084295924322 1.54551622173259e-34 -1.35870465626211 3.34572839723252e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.752563630948822 3.02619719501452e-20 NA NA NA hsa-miR-194-5p SOX6 -0.292530160992458 0.0996141384876663 -2.13149609157814 4.50445986535194e-12 miRNATAP -0.181463370101937 0.0372004085073772 NA NA NA hsa-miR-19b-3p SOX6 0.601279551368824 0.00016685097085251 -2.13149609157814 4.50445986535194e-12 MirTarget;miRNATAP -0.235051398723744 0.0145618336308158 NA NA NA hsa-miR-21-5p SOX6 1.51084295924322 1.54551622173259e-34 -2.13149609157814 4.50445986535194e-12 MirTarget;miRNATAP -0.442546399262666 0.00011832613787611 NA NA NA hsa-miR-224-3p SOX6 1.40770116795301 1.31426607144612e-08 -2.13149609157814 4.50445986535194e-12 mirMAP -0.132839091450254 0.0323344097601481 NA NA NA hsa-miR-34a-5p SOX6 1.03694231790865 5.74864019540594e-14 -2.13149609157814 4.50445986535194e-12 miRNATAP -0.420272368551711 0.000102613014878181 NA NA NA hsa-miR-21-5p SOX7 1.51084295924322 1.54551622173259e-34 -0.986286162209553 5.18629323126467e-07 miRNATAP -0.456800368812046 1.40622099782934e-10 NA NA NA hsa-miR-30e-5p SOX9 -0.627815042856657 3.02205690184908e-10 0.456898781063352 0.178110113816873 MirTarget -0.794789900236748 9.82298473299795e-07 NA NA NA hsa-miR-27b-3p SP6 -0.823491817819754 9.20935302746823e-14 2.23551885984922 1.02825725864058e-20 miRNATAP -0.420559598547192 9.77723698387977e-05 NA NA NA hsa-miR-15a-5p SPAG7 0.349521211668244 0.000770735998804736 -0.567072090952965 2.91589106094725e-07 miRNATAP -0.126842691625178 0.0162003882882043 NA NA NA hsa-miR-181a-5p SPAG9 0.250113435902954 0.0551933249319293 -0.425454130288859 8.56735152376549e-07 mirMAP;miRNATAP -0.175118524432518 5.87658112542314e-08 NA NA NA hsa-miR-181b-5p SPAG9 0.488256489401108 0.00105321129419701 -0.425454130288859 8.56735152376549e-07 mirMAP;miRNATAP -0.160978497530553 9.328769869473e-09 NA NA NA hsa-miR-192-5p SPARC -0.50188499512787 0.00344713341196035 0.718137488173 6.98854384110794e-07 miRNAWalker2_validate -0.376480630141672 1.70979260364267e-21 NA NA NA hsa-miR-455-5p SPARC -0.270546034117157 0.0581320703577731 0.718137488173 6.98854384110794e-07 miRanda -0.229838430645835 3.82495469501829e-06 NA NA NA hsa-miR-29c-3p SPAST -1.4367517608807 1.61767774905781e-21 0.0860364295301137 0.207982778574537 MirTarget;miRNATAP -0.111672670385282 5.83835208208972e-08 NA NA NA hsa-miR-30b-5p SPAST -0.54056186708617 2.44688760798341e-05 0.0860364295301137 0.207982778574537 MirTarget;mirMAP -0.116527353460473 4.82877225612104e-06 NA NA NA hsa-miR-192-3p SPATA17 -0.6401165114007 0.000266272092403814 0.670625412580457 0.0420481448904262 mirMAP -0.493897447541772 4.08539821687076e-08 NA NA NA hsa-miR-21-5p SPATA18 1.51084295924322 1.54551622173259e-34 -2.42440573416054 6.14787335383988e-13 mirMAP -0.888168123228807 5.84448638593106e-13 NA NA NA hsa-miR-455-5p SPEG -0.270546034117157 0.0581320703577731 -0.318044802616168 0.336019689075101 miRanda -0.395054364451505 0.000460806487028748 NA NA NA hsa-miR-21-5p SPG11 1.51084295924322 1.54551622173259e-34 -0.217404490510732 0.0127089782026275 miRNAWalker2_validate -0.131221875348133 3.25452731693718e-05 NA NA NA hsa-miR-19b-3p SPG20 0.601279551368824 0.00016685097085251 -2.0188037720553 2.56848033710916e-20 miRNAWalker2_validate;miRNATAP -0.26709374918425 0.000118516015008906 NA NA NA hsa-miR-21-5p SPG20 1.51084295924322 1.54551622173259e-34 -2.0188037720553 2.56848033710916e-20 miRNATAP -0.36514192341709 1.12103205042907e-05 NA NA NA hsa-miR-34a-5p SPI1 1.03694231790865 5.74864019540594e-14 -0.800193158521703 1.91855009176875e-06 miRNAWalker2_validate -0.152865570899956 0.00884977652379596 NA NA NA hsa-miR-146b-5p SPIN1 0.419719546795449 0.0457375823220155 -0.173743578973942 0.107261524360596 miRanda -0.103505831051958 2.98526519682382e-05 NA NA NA hsa-miR-21-5p SPIN1 1.51084295924322 1.54551622173259e-34 -0.173743578973942 0.107261524360596 miRNAWalker2_validate;miRNATAP -0.146320667513631 0.000182886372082751 NA NA NA hsa-miR-29c-3p SPIN4 -1.4367517608807 1.61767774905781e-21 0.282634245218971 0.0688547961399822 miRNAWalker2_validate;MirTarget -0.210741782337734 8.8925595454026e-06 NA NA NA hsa-miR-455-5p SPINK5 -0.270546034117157 0.0581320703577731 2.64420987169299 1.01420396118544e-11 miRanda -0.464156151281767 0.000658128850648802 NA NA NA hsa-miR-99a-5p SPIRE1 -1.51481656384839 3.93230057259529e-14 -0.807515058990267 0.00059390232481735 miRNAWalker2_validate -0.121270883591381 0.0298111599678265 NA NA NA hsa-miR-455-5p SPN -0.270546034117157 0.0581320703577731 -0.821701237306736 2.20709546225404e-05 mirMAP -0.199970641328117 0.00277369363644372 NA NA NA hsa-miR-29c-3p SPNS1 -1.4367517608807 1.61767774905781e-21 0.737651462121133 1.11217142100497e-17 miRNATAP -0.169656243122962 3.37017331192327e-10 NA NA NA hsa-miR-192-3p SPOCK2 -0.6401165114007 0.000266272092403814 0.102719482204722 0.565189656826931 mirMAP -0.223047112394766 4.97442206873427e-06 NA NA NA hsa-miR-15a-5p SPRED1 0.349521211668244 0.000770735998804736 -0.584055575592488 6.88990777515141e-05 miRNATAP -0.189523601555987 0.00647253346256402 NA NA NA hsa-miR-194-5p SPRED1 -0.292530160992458 0.0996141384876663 -0.584055575592488 6.88990777515141e-05 miRNATAP -0.3930772309152 1.1090686314509e-24 NA NA NA hsa-miR-20a-5p SPRED1 0.854326758727003 5.04256669663285e-07 -0.584055575592488 6.88990777515141e-05 miRNATAP -0.165176765151827 7.31830031380624e-05 NA NA NA hsa-miR-34a-5p SPRED1 1.03694231790865 5.74864019540594e-14 -0.584055575592488 6.88990777515141e-05 miRNATAP -0.271515837377171 5.93841154487705e-08 NA NA NA hsa-miR-21-5p SPRY1 1.51084295924322 1.54551622173259e-34 -0.191200095311501 0.161703034220406 miRNATAP -0.14613864441268 0.00329886441657982 24155920 Functional studies showed that miR-21 over-expression in GICs induced comparable cell differentiation features and targeted SPRY1 mRNA which encodes for a negative regulator of neural stem-cell differentiation differentiation glioblastoma hsa-miR-21-5p SPRY2 1.51084295924322 1.54551622173259e-34 -1.61009043608154 1.29635420799403e-31 miRNAWalker2_validate;miRTarBase;miRNATAP -0.425735867826972 4.40806254549318e-16 22322462 Inhibition of microRNA-21 mir‑21 induced upregulation of Spry2 and PTEN which underscores the importance of mir-21 in Spry2-associated tumorigenesis of the colon tumorigenesis colon cancer hsa-miR-192-5p SPRY4 -0.50188499512787 0.00344713341196035 -0.334402157998528 0.0123258475801913 miRNAWalker2_validate -0.12594333673096 0.000869467405159125 NA NA NA hsa-miR-29c-3p SPTAN1 -1.4367517608807 1.61767774905781e-21 0.68130865816582 4.44449039385979e-22 miRNATAP -0.184728181534582 3.42055067501409e-17 NA NA NA hsa-miR-192-3p SPTB -0.6401165114007 0.000266272092403814 0.423775285295859 0.021696187584307 mirMAP -0.307251808164845 8.95511559506921e-10 NA NA NA hsa-miR-505-5p SPTB -0.768282569967001 1.14662846595407e-05 0.423775285295859 0.021696187584307 mirMAP -0.102282046637763 0.0453754242097491 NA NA NA hsa-miR-15a-5p SPTBN2 0.349521211668244 0.000770735998804736 -2.08227120143273 3.02932939302785e-12 MirTarget;miRNATAP -0.36707663096198 0.011139117347768 NA NA NA hsa-miR-222-3p SPTBN2 1.08574156066353 1.76407192348131e-11 -2.08227120143273 3.02932939302785e-12 miRNAWalker2_validate -0.635056845520948 5.80062915583512e-13 NA NA NA hsa-miR-34a-5p SPTBN2 1.03694231790865 5.74864019540594e-14 -2.08227120143273 3.02932939302785e-12 miRNATAP -0.340726862968205 0.00119800789701576 NA NA NA hsa-miR-17-3p SPTLC2 0.410352776142368 0.00422200500748636 -0.0868232595913723 0.352460556805591 MirTarget -0.131292952565062 2.90441392460887e-05 NA NA NA hsa-miR-19b-3p SPTLC2 0.601279551368824 0.00016685097085251 -0.0868232595913723 0.352460556805591 mirMAP -0.117616743464124 2.77165466565118e-05 NA NA NA hsa-miR-30b-5p SPTLC2 -0.54056186708617 2.44688760798341e-05 -0.0868232595913723 0.352460556805591 mirMAP -0.110681760712483 0.00165178098227479 NA NA NA hsa-miR-455-5p SPTLC2 -0.270546034117157 0.0581320703577731 -0.0868232595913723 0.352460556805591 miRanda -0.149643474995875 2.08559312084384e-06 NA NA NA hsa-miR-21-5p SPTLC3 1.51084295924322 1.54551622173259e-34 -1.10803369124109 1.07050221229424e-07 miRNAWalker2_validate -0.301824182256997 8.61062447291768e-05 NA NA NA hsa-miR-21-5p SPTY2D1 1.51084295924322 1.54551622173259e-34 -0.240993112197188 0.000856993759157496 mirMAP -0.102380754626533 9.42383843828826e-05 NA NA NA hsa-miR-194-5p SRCAP -0.292530160992458 0.0996141384876663 0.421682590950924 3.73904929006151e-08 miRNAWalker2_validate -0.105321230314368 5.70141333157383e-07 NA NA NA hsa-miR-132-3p SRCIN1 0.323796239695997 0.00272093067935091 0.0572903847582404 0.79284156387504 mirMAP -0.206026137157591 0.0373184985006064 NA NA NA hsa-miR-20a-5p SRCIN1 0.854326758727003 5.04256669663285e-07 0.0572903847582404 0.79284156387504 MirTarget -0.156461625478448 0.0112678615010555 NA NA NA hsa-miR-20b-5p SRCIN1 0.457668023910379 0.0285865211936156 0.0572903847582404 0.79284156387504 MirTarget -0.224804318393794 7.96403507919007e-06 NA NA NA hsa-miR-146a-5p SRD5A2 -0.742958238440575 0.000765983177482633 -3.91305288902984 1.41711489044132e-19 MirTarget -0.312781365663085 0.00164081203310443 NA NA NA hsa-miR-19b-3p SRGAP1 0.601279551368824 0.00016685097085251 0.526529645216711 0.00998247204415749 mirMAP -0.247786955383109 6.24473098651675e-05 NA NA NA hsa-miR-27b-3p SRGAP2 -0.823491817819754 9.20935302746823e-14 0.77156783154035 3.52407714516935e-11 MirTarget -0.248550531210308 1.00887772701706e-06 NA NA NA hsa-miR-194-5p SRGAP3 -0.292530160992458 0.0996141384876663 0.271507432908788 0.17260362358842 mirMAP -0.149542661066227 0.00620691640833376 NA NA NA hsa-miR-19b-3p SRGAP3 0.601279551368824 0.00016685097085251 0.271507432908788 0.17260362358842 mirMAP;miRNATAP -0.20546459774104 0.000652501409267844 NA NA NA hsa-miR-20a-5p SRGAP3 0.854326758727003 5.04256669663285e-07 0.271507432908788 0.17260362358842 miRNATAP -0.154099853924408 0.00624812089790598 NA NA NA hsa-miR-20b-5p SRGAP3 0.457668023910379 0.0285865211936156 0.271507432908788 0.17260362358842 miRNATAP -0.113858122028921 0.0140482867887796 NA NA NA hsa-miR-27b-3p SRGAP3 -0.823491817819754 9.20935302746823e-14 0.271507432908788 0.17260362358842 miRNATAP -0.239084692378411 0.00526617019551541 NA NA NA hsa-miR-194-5p SRGN -0.292530160992458 0.0996141384876663 -1.26578086639201 1.76284690770496e-13 MirTarget -0.27060375320227 1.65731967043117e-08 NA NA NA hsa-miR-20a-5p SRL 0.854326758727003 5.04256669663285e-07 -0.709345641602721 8.73318839614034e-05 mirMAP -0.17860282416388 0.000517359452459933 NA NA NA hsa-miR-455-3p SRM -1.3998033821095 5.72010709806871e-17 0.688637840795698 7.19785272634918e-09 miRNAWalker2_validate -0.163332879381044 1.18723261302726e-06 NA NA NA hsa-miR-99a-5p SRPK1 -1.51481656384839 3.93230057259529e-14 0.546430300806312 9.51704538407861e-09 miRNAWalker2_validate -0.158347705547835 9.7176297034438e-13 NA NA NA hsa-miR-148a-3p SRRM3 -0.748702855596996 3.93313343865641e-07 1.37120942849299 0.000135491162818506 mirMAP -0.705228453146128 1.29888212423459e-09 NA NA NA hsa-miR-181a-5p SS18L1 0.250113435902954 0.0551933249319293 -0.296492401776284 0.0220761965048876 miRNATAP -0.444112993902365 7.71978273217747e-22 NA NA NA hsa-miR-181b-5p SS18L1 0.488256489401108 0.00105321129419701 -0.296492401776284 0.0220761965048876 miRNATAP -0.444233671193941 1.94729781151765e-29 NA NA NA hsa-miR-182-5p SS18L1 1.96601340710222 4.39326175603633e-09 -0.296492401776284 0.0220761965048876 miRNATAP -0.132570354678059 1.5272405549191e-13 NA NA NA hsa-miR-146b-5p SSBP2 0.419719546795449 0.0457375823220155 -0.124114637043314 0.588013472488598 mirMAP -0.133494789084205 0.0118902333188034 NA NA NA hsa-miR-148a-3p SSBP2 -0.748702855596996 3.93313343865641e-07 -0.124114637043314 0.588013472488598 MirTarget -0.630106222214928 1.58562698769295e-18 NA NA NA hsa-miR-21-5p SSFA2 1.51084295924322 1.54551622173259e-34 -1.04867750273814 9.35976525656476e-18 miRNAWalker2_validate;miRNATAP -0.440458857136484 1.21522358351572e-23 NA NA NA hsa-miR-194-5p SSH2 -0.292530160992458 0.0996141384876663 0.308455324497014 0.00122785737698821 miRNATAP -0.153073782233296 3.05017147955846e-09 NA NA NA hsa-miR-29c-3p SSTR5 -1.4367517608807 1.61767774905781e-21 1.29314726381889 0.00378788943107353 mirMAP -0.49374883847446 0.000331115136507935 NA NA NA hsa-miR-181a-5p SSX2IP 0.250113435902954 0.0551933249319293 0.284146878517911 0.111114755854163 MirTarget;mirMAP;miRNATAP -0.493449679706968 2.9689313886754e-14 NA NA NA hsa-miR-181b-5p SSX2IP 0.488256489401108 0.00105321129419701 0.284146878517911 0.111114755854163 MirTarget;mirMAP;miRNATAP -0.42597272142725 4.78310754424482e-14 NA NA NA hsa-miR-20a-5p SSX2IP 0.854326758727003 5.04256669663285e-07 0.284146878517911 0.111114755854163 MirTarget;miRNATAP -0.133345184368822 0.00829529021779053 NA NA NA hsa-miR-30b-5p SSX2IP -0.54056186708617 2.44688760798341e-05 0.284146878517911 0.111114755854163 MirTarget -0.218619084377488 0.00118801084966888 NA NA NA hsa-miR-182-5p ST3GAL1 1.96601340710222 4.39326175603633e-09 -0.767532914178657 6.27233158530294e-05 mirMAP -0.132487913550444 1.1907904868075e-06 NA NA NA hsa-miR-20b-5p ST3GAL1 0.457668023910379 0.0285865211936156 -0.767532914178657 6.27233158530294e-05 miRNATAP -0.120454925724035 0.00743880343881394 NA NA NA hsa-miR-19b-3p ST3GAL5 0.601279551368824 0.00016685097085251 -0.475534176178988 0.000105032462180366 MirTarget;miRNATAP -0.228827716900306 4.82099468625623e-10 NA NA NA hsa-miR-146b-5p ST5 0.419719546795449 0.0457375823220155 0.278068285654941 0.0176361883991604 miRNATAP -0.121431933050784 6.59884098161963e-06 NA NA NA hsa-miR-21-5p ST6GAL1 1.51084295924322 1.54551622173259e-34 -1.06038675540743 4.87924984478722e-10 miRNAWalker2_validate -0.381531456669473 9.47233085735488e-10 NA NA NA hsa-miR-146b-5p ST6GAL2 0.419719546795449 0.0457375823220155 -3.9429649510976 1.34875955382256e-24 miRanda -0.308137938280701 0.00113058910872754 NA NA NA hsa-miR-192-3p ST6GAL2 -0.6401165114007 0.000266272092403814 -3.9429649510976 1.34875955382256e-24 mirMAP -0.565666840496705 4.17618039141687e-07 NA NA NA hsa-miR-182-5p ST6GALNAC3 1.96601340710222 4.39326175603633e-09 -1.04258541098903 2.10396558808448e-09 mirMAP -0.115444617342645 4.1707303521318e-06 NA NA NA hsa-miR-20a-5p ST6GALNAC3 0.854326758727003 5.04256669663285e-07 -1.04258541098903 2.10396558808448e-09 MirTarget -0.297600391121308 1.71634357155285e-09 NA NA NA hsa-miR-20a-5p ST6GALNAC6 0.854326758727003 5.04256669663285e-07 -0.858012119719114 8.21086038364155e-13 MirTarget;miRNATAP -0.151524329670897 1.2219714559824e-05 NA NA NA hsa-miR-192-3p ST8SIA1 -0.6401165114007 0.000266272092403814 0.303148453883592 0.256284129204521 MirTarget -0.486344017827725 1.49715652786038e-11 NA NA NA hsa-miR-27b-3p ST8SIA1 -0.823491817819754 9.20935302746823e-14 0.303148453883592 0.256284129204521 miRNATAP -0.249800856180043 0.0300737664448183 NA NA NA hsa-miR-21-5p ST8SIA3 1.51084295924322 1.54551622173259e-34 -2.69127578966183 3.01156225530941e-11 mirMAP -0.719320570916538 1.65097221003899e-06 NA NA NA hsa-miR-30e-5p STAC -0.627815042856657 3.02205690184908e-10 -1.60463674281237 3.18193116669078e-06 MirTarget -0.375072281550512 0.0261849372689529 NA NA NA hsa-miR-30b-5p STAG1 -0.54056186708617 2.44688760798341e-05 -0.178198619776885 0.243967920887864 MirTarget -0.20850853639894 0.00030033116479739 NA NA NA hsa-miR-181a-5p STAG2 0.250113435902954 0.0551933249319293 -0.0714198831818473 0.421841747970601 miRNAWalker2_validate -0.136157385997054 3.70034379856412e-05 NA NA NA hsa-miR-21-5p STAG2 1.51084295924322 1.54551622173259e-34 -0.0714198831818473 0.421841747970601 miRNAWalker2_validate;MirTarget;miRNATAP -0.137742528039037 1.73808146164746e-05 NA NA NA hsa-miR-455-5p STAMBPL1 -0.270546034117157 0.0581320703577731 1.0623321332185 1.08478450170134e-07 miRanda -0.180183462235251 0.00956646090362133 NA NA NA hsa-miR-182-5p STARD13 1.96601340710222 4.39326175603633e-09 -0.434726833151241 0.000841151501879479 miRNATAP -0.122732460536177 1.57293196781861e-11 NA NA NA hsa-miR-455-5p STARD3NL -0.270546034117157 0.0581320703577731 0.140337006185873 0.201694234710223 miRanda -0.169897310430185 5.01346355801955e-06 NA NA NA hsa-miR-181a-5p STARD4 0.250113435902954 0.0551933249319293 -0.696471447741415 3.61296761564288e-05 MirTarget;mirMAP -0.162229680280553 0.0110183355846721 NA NA NA hsa-miR-181b-5p STARD4 0.488256489401108 0.00105321129419701 -0.696471447741415 3.61296761564288e-05 MirTarget;mirMAP -0.160338629134663 0.00383257436144798 NA NA NA hsa-miR-34a-5p STAT1 1.03694231790865 5.74864019540594e-14 0.0211728282562005 0.88997583338294 miRNAWalker2_validate -0.128228142214682 0.0145624375052668 NA NA NA hsa-miR-455-5p STAT1 -0.270546034117157 0.0581320703577731 0.0211728282562005 0.88997583338294 miRanda -0.147591756706305 0.0047396940322775 NA NA NA hsa-miR-20a-5p STAT3 0.854326758727003 5.04256669663285e-07 -0.787818268277734 2.21497977966771e-15 miRNAWalker2_validate;miRNATAP -0.204002628417709 5.95071178568667e-13 NA NA NA hsa-miR-132-3p STAU1 0.323796239695997 0.00272093067935091 -0.325342047009626 1.85181071649822e-05 miRNAWalker2_validate -0.146008452827478 2.14346785643525e-05 NA NA NA hsa-miR-30e-5p STC1 -0.627815042856657 3.02205690184908e-10 1.1939080061533 1.49954780653484e-08 mirMAP -0.21761433847902 0.036206883270572 NA NA NA hsa-miR-455-5p STC1 -0.270546034117157 0.0581320703577731 1.1939080061533 1.49954780653484e-08 PITA;miRanda -0.199940214077749 0.00649884507735575 NA NA NA hsa-miR-182-5p STEAP2 1.96601340710222 4.39326175603633e-09 -0.3879919292867 0.277011129421725 MirTarget -0.148355507204501 0.0035028422585781 NA NA NA hsa-miR-224-3p STEAP2 1.40770116795301 1.31426607144612e-08 -0.3879919292867 0.277011129421725 mirMAP -0.178170017434537 0.0107944912357547 NA NA NA hsa-miR-192-5p STIL -0.50188499512787 0.00344713341196035 2.27606240799083 3.73674028972289e-36 miRNAWalker2_validate -0.168612906064759 0.00267011641470547 NA NA NA hsa-miR-215-5p STIL -0.981544773246509 3.14452272477156e-05 2.27606240799083 3.73674028972289e-36 miRNAWalker2_validate -0.10403298924848 0.0104249941277857 NA NA NA hsa-miR-192-3p STK10 -0.6401165114007 0.000266272092403814 0.0752914305222703 0.466277639236209 mirMAP -0.192625954253145 3.894914140158e-12 NA NA NA hsa-miR-192-5p STK17B -0.50188499512787 0.00344713341196035 -0.443052997570354 0.011484300538988 miRNAWalker2_validate -0.326984567808828 1.84309115333926e-11 NA NA NA hsa-miR-455-3p STK17B -1.3998033821095 5.72010709806871e-17 -0.443052997570354 0.011484300538988 miRNATAP -0.291530504492222 1.75295196016957e-09 NA NA NA hsa-miR-29c-3p STK19 -1.4367517608807 1.61767774905781e-21 0.880171851686923 1.54924658483424e-18 miRNAWalker2_validate -0.177733071788086 1.99237759814219e-08 NA NA NA hsa-miR-148a-3p STK24 -0.748702855596996 3.93313343865641e-07 0.19247054896382 0.0273376591701568 mirMAP -0.171740620181524 7.53809919687189e-10 NA NA NA hsa-miR-19b-3p STK32B 0.601279551368824 0.00016685097085251 0.825477729275744 0.000150809942053144 MirTarget -0.203987683272128 0.00217346461787536 NA NA NA hsa-miR-27b-3p STK32B -0.823491817819754 9.20935302746823e-14 0.825477729275744 0.000150809942053144 MirTarget -0.214864106788388 0.0231588783641708 NA NA NA hsa-miR-455-5p STK32B -0.270546034117157 0.0581320703577731 0.825477729275744 0.000150809942053144 miRanda -0.393725766986408 1.10758077337087e-07 NA NA NA hsa-miR-29c-3p STK35 -1.4367517608807 1.61767774905781e-21 0.639486866463096 6.71501847710025e-11 mirMAP;miRNATAP -0.240279952681886 6.60312845221165e-16 NA NA NA hsa-miR-30b-5p STK35 -0.54056186708617 2.44688760798341e-05 0.639486866463096 6.71501847710025e-11 MirTarget;mirMAP -0.102566652206967 0.0068229885200341 NA NA NA hsa-miR-148a-3p STK38L -0.748702855596996 3.93313343865641e-07 -0.426911630799545 7.77556827907282e-05 MirTarget -0.167682651806632 1.85608742152544e-06 NA NA NA hsa-miR-17-3p STK38L 0.410352776142368 0.00422200500748636 -0.426911630799545 7.77556827907282e-05 MirTarget -0.10232782888713 0.00557178030493205 NA NA NA hsa-miR-34a-5p STK38L 1.03694231790865 5.74864019540594e-14 -0.426911630799545 7.77556827907282e-05 MirTarget -0.230676772002766 2.91409706654917e-10 NA NA NA hsa-miR-192-3p STK39 -0.6401165114007 0.000266272092403814 1.59540335392395 1.26186756425741e-09 MirTarget -0.547950462095597 2.49347132876159e-14 NA NA NA hsa-miR-27b-3p STK39 -0.823491817819754 9.20935302746823e-14 1.59540335392395 1.26186756425741e-09 MirTarget;miRNATAP -0.466264252532839 4.95886616233495e-05 NA NA NA hsa-miR-30e-5p STK39 -0.627815042856657 3.02205690184908e-10 1.59540335392395 1.26186756425741e-09 MirTarget -0.882294319882698 3.04169342686762e-12 NA NA NA hsa-miR-21-5p STK40 1.51084295924322 1.54551622173259e-34 -0.821847220109252 4.78818932052572e-18 MirTarget;miRNATAP -0.185491264902573 1.89215466830158e-07 NA NA NA hsa-miR-192-3p STMN3 -0.6401165114007 0.000266272092403814 0.135612094502139 0.569052800067295 mirMAP -0.480485864362819 5.05988838234408e-14 NA NA NA hsa-miR-20a-5p STOM 0.854326758727003 5.04256669663285e-07 -1.17367594082242 4.33645251602994e-16 MirTarget -0.131363211817613 0.00193036612853252 NA NA NA hsa-miR-30c-5p STOML1 -0.432111642767632 0.000159764714931007 0.652825199067254 6.92321661383767e-10 MirTarget -0.222876683191623 9.56560627770241e-07 NA NA NA hsa-miR-30e-5p STOML1 -0.627815042856657 3.02205690184908e-10 0.652825199067254 6.92321661383767e-10 MirTarget -0.305713350859013 2.43344221888362e-09 NA NA NA hsa-miR-15a-5p STON1 0.349521211668244 0.000770735998804736 -0.562349371044789 0.00511224870344449 MirTarget -0.489162038818366 1.82618686465418e-07 NA NA NA hsa-miR-17-3p STOX2 0.410352776142368 0.00422200500748636 -0.525554735878651 0.0469429734780629 mirMAP -0.270951046999182 0.00258271078121475 NA NA NA hsa-miR-455-5p STRA6 -0.270546034117157 0.0581320703577731 1.95364896362943 4.3338537722737e-07 miRanda -0.542180084845673 4.88847746949224e-05 NA NA NA hsa-miR-146b-5p STRN 0.419719546795449 0.0457375823220155 -0.58546343433889 0.00627909767123357 miRanda;miRNATAP -0.128022259130838 0.0101850203398451 NA NA NA hsa-miR-30b-5p STRN -0.54056186708617 2.44688760798341e-05 -0.58546343433889 0.00627909767123357 mirMAP -0.283925172106924 0.000470571777905936 NA NA NA hsa-miR-34a-5p STRN3 1.03694231790865 5.74864019540594e-14 -0.689706941078372 1.21970586430247e-14 MirTarget;miRNATAP -0.141018699092784 7.08962955861611e-06 NA NA NA hsa-miR-29c-3p STRN4 -1.4367517608807 1.61767774905781e-21 0.56791074979485 5.57133020759267e-16 miRNATAP -0.192278360947993 1.78680102848691e-19 NA NA NA hsa-miR-181a-5p STS 0.250113435902954 0.0551933249319293 -0.861172877158497 5.40693465418864e-06 mirMAP -0.151102929873477 0.0356636658366565 NA NA NA hsa-miR-455-5p STS -0.270546034117157 0.0581320703577731 -0.861172877158497 5.40693465418864e-06 miRanda -0.452635176397018 1.36554181914077e-12 NA NA NA hsa-miR-455-5p STT3B -0.270546034117157 0.0581320703577731 -0.0769758818709851 0.617711946589213 miRNATAP -0.110637684940283 0.0360729630295657 NA NA NA hsa-miR-181a-5p STX12 0.250113435902954 0.0551933249319293 -0.319661166824595 7.73724696997829e-07 mirMAP -0.145408932973694 1.31028607364386e-09 NA NA NA hsa-miR-181b-5p STX12 0.488256489401108 0.00105321129419701 -0.319661166824595 7.73724696997829e-07 mirMAP -0.134497094728664 9.82755217672181e-11 NA NA NA hsa-miR-29c-3p STX16 -1.4367517608807 1.61767774905781e-21 0.526929733235254 1.8845064804419e-12 MirTarget -0.146813380568911 2.01312927850053e-10 NA NA NA hsa-miR-34a-5p STX17 1.03694231790865 5.74864019540594e-14 -0.569012987211075 6.74630906549539e-13 MirTarget -0.115895307892053 2.85696218528765e-05 NA NA NA hsa-miR-182-5p STX1B 1.96601340710222 4.39326175603633e-09 -0.640719876691996 0.00172836284903972 mirMAP -0.117729132202814 5.23772063838262e-05 NA NA NA hsa-miR-20a-5p STX1B 0.854326758727003 5.04256669663285e-07 -0.640719876691996 0.00172836284903972 mirMAP -0.256725055224052 8.74254638986174e-06 NA NA NA hsa-miR-20b-5p STX1B 0.457668023910379 0.0285865211936156 -0.640719876691996 0.00172836284903972 mirMAP -0.126520839939248 0.00815226420961742 NA NA NA hsa-miR-221-3p STX1B 1.12244756358612 3.48370308238012e-13 -0.640719876691996 0.00172836284903972 miRNATAP -0.457879211104611 8.3348808250142e-14 NA NA NA hsa-miR-222-3p STX1B 1.08574156066353 1.76407192348131e-11 -0.640719876691996 0.00172836284903972 miRNATAP -0.477738364768145 3.09027831152936e-16 NA NA NA hsa-miR-192-5p STX3 -0.50188499512787 0.00344713341196035 0.268625915502391 0.0620467313021486 mirMAP -0.211737736672339 1.48582774569338e-07 NA NA NA hsa-miR-27b-3p STX6 -0.823491817819754 9.20935302746823e-14 0.82528361429447 1.08822274383182e-21 miRNATAP -0.160405645302782 3.51623310194333e-05 NA NA NA hsa-miR-30e-5p STX6 -0.627815042856657 3.02205690184908e-10 0.82528361429447 1.08822274383182e-21 mirMAP -0.274151776173967 1.63443697436258e-10 NA NA NA hsa-miR-455-3p STX6 -1.3998033821095 5.72010709806871e-17 0.82528361429447 1.08822274383182e-21 MirTarget -0.113070773815415 7.27262901058302e-06 NA NA NA hsa-miR-192-5p STX7 -0.50188499512787 0.00344713341196035 -0.0311327507585233 0.718803465757857 miRNAWalker2_validate -0.155186048793629 7.95347641737271e-11 NA NA NA hsa-miR-455-5p STXBP3 -0.270546034117157 0.0581320703577731 -0.237817206137129 0.00746448175053259 miRanda -0.120649911712418 6.62110227698405e-05 NA NA NA hsa-miR-27b-3p STXBP4 -0.823491817819754 9.20935302746823e-14 0.825288412971413 2.03775790430092e-09 mirMAP -0.321635616790522 6.9505961800388e-08 NA NA NA hsa-miR-455-5p STXBP4 -0.270546034117157 0.0581320703577731 0.825288412971413 2.03775790430092e-09 miRanda -0.197183598571176 3.62662992980914e-05 NA NA NA hsa-miR-30c-5p STXBP6 -0.432111642767632 0.000159764714931007 1.62128941420745 1.76704015017652e-15 mirMAP -0.323108080246852 0.00031375108478501 NA NA NA hsa-miR-30e-5p STXBP6 -0.627815042856657 3.02205690184908e-10 1.62128941420745 1.76704015017652e-15 mirMAP -0.417819946490364 3.83112454927612e-05 NA NA NA hsa-miR-29c-3p SUB1 -1.4367517608807 1.61767774905781e-21 0.583706814960803 1.03979976716946e-11 MirTarget -0.130209384456759 1.10986725108126e-06 NA NA NA hsa-miR-30e-5p SUB1 -0.627815042856657 3.02205690184908e-10 0.583706814960803 1.03979976716946e-11 mirMAP -0.241122013366274 7.62130880901144e-09 NA NA NA hsa-miR-17-3p SUCLG2 0.410352776142368 0.00422200500748636 -1.20459027018039 2.73963638862473e-20 MirTarget -0.134443384428543 0.00382484127339069 NA NA NA hsa-miR-181a-5p SUCLG2 0.250113435902954 0.0551933249319293 -1.20459027018039 2.73963638862473e-20 MirTarget -0.335184396928178 2.50348124348773e-11 NA NA NA hsa-miR-181b-5p SUCLG2 0.488256489401108 0.00105321129419701 -1.20459027018039 2.73963638862473e-20 MirTarget -0.353267035180522 2.54271032479074e-16 NA NA NA hsa-miR-148a-3p SULF1 -0.748702855596996 3.93313343865641e-07 0.197109789821601 0.550013822507954 miRNATAP -1.08819294190457 4.5465214196856e-27 NA NA NA hsa-miR-455-3p SULF1 -1.3998033821095 5.72010709806871e-17 0.197109789821601 0.550013822507954 PITA -0.517593171699363 1.32473837001195e-08 NA NA NA hsa-miR-27b-3p SULT4A1 -0.823491817819754 9.20935302746823e-14 0.999766279782465 0.0548748431251418 miRNATAP -0.523819206369966 0.01984545649168 NA NA NA hsa-miR-221-3p SUN2 1.12244756358612 3.48370308238012e-13 -0.932850868223685 1.96552976055956e-16 miRNATAP -0.177235744649676 7.34315451746358e-07 NA NA NA hsa-miR-222-3p SUN2 1.08574156066353 1.76407192348131e-11 -0.932850868223685 1.96552976055956e-16 miRNAWalker2_validate;miRNATAP -0.208676102533143 9.16263392685138e-10 NA NA NA hsa-miR-30e-5p SUPT3H -0.627815042856657 3.02205690184908e-10 0.819844906050205 1.7749535024518e-07 MirTarget -0.237599403726711 0.00198951017463479 NA NA NA hsa-miR-455-5p SUSD1 -0.270546034117157 0.0581320703577731 0.0975603311994271 0.554306463209484 miRanda -0.126627699014496 0.024902825406503 NA NA NA hsa-miR-455-5p SUSD5 -0.270546034117157 0.0581320703577731 -0.865501706448957 0.00678012077888868 miRanda -0.450676013979291 3.65602380748262e-05 NA NA NA hsa-miR-224-3p SV2B 1.40770116795301 1.31426607144612e-08 -0.646602435220179 0.0535943798302934 mirMAP -0.166648756839609 0.011195932451647 NA NA NA hsa-miR-146b-5p SVIL 0.419719546795449 0.0457375823220155 0.273118091237202 0.0741882650212855 PITA;miRanda -0.158323007913688 6.73985475255865e-06 NA NA NA hsa-miR-17-3p SYAP1 0.410352776142368 0.00422200500748636 -0.463033190243062 1.43154636189129e-07 mirMAP -0.124937536108775 3.246499876039e-05 NA NA NA hsa-miR-181a-5p SYAP1 0.250113435902954 0.0551933249319293 -0.463033190243062 1.43154636189129e-07 mirMAP -0.161012092379552 1.11971365218257e-06 NA NA NA hsa-miR-181b-5p SYAP1 0.488256489401108 0.00105321129419701 -0.463033190243062 1.43154636189129e-07 mirMAP -0.138657851610453 1.44132296636033e-06 NA NA NA hsa-miR-19b-3p SYBU 0.601279551368824 0.00016685097085251 -1.03424280598767 8.76454515036323e-06 miRNAWalker2_validate;MirTarget;miRNATAP -0.379410994046336 7.31955980071129e-08 NA NA NA hsa-miR-20a-5p SYBU 0.854326758727003 5.04256669663285e-07 -1.03424280598767 8.76454515036323e-06 MirTarget;miRNATAP -0.348242368017228 1.19166978473753e-07 NA NA NA hsa-miR-20b-5p SYBU 0.457668023910379 0.0285865211936156 -1.03424280598767 8.76454515036323e-06 MirTarget;miRNATAP -0.262011677481542 1.34207444905456e-06 NA NA NA hsa-miR-221-3p SYBU 1.12244756358612 3.48370308238012e-13 -1.03424280598767 8.76454515036323e-06 MirTarget;miRNATAP -0.533431254409308 2.80510282121204e-14 NA NA NA hsa-miR-222-3p SYBU 1.08574156066353 1.76407192348131e-11 -1.03424280598767 8.76454515036323e-06 MirTarget;miRNATAP -0.62455785333402 3.25513796276304e-21 NA NA NA hsa-miR-15a-5p SYDE1 0.349521211668244 0.000770735998804736 -0.0910974798508875 0.557737365754261 miRNATAP -0.18250281505893 0.0125355207678427 NA NA NA hsa-miR-27b-3p SYDE1 -0.823491817819754 9.20935302746823e-14 -0.0910974798508875 0.557737365754261 miRNATAP -0.168582477232069 0.011669253407176 NA NA NA hsa-miR-148a-3p SYNC -0.748702855596996 3.93313343865641e-07 0.753263996165908 0.0787951206130033 MirTarget -0.607317552921147 1.27523918840447e-05 NA NA NA hsa-miR-20a-5p SYNE1 0.854326758727003 5.04256669663285e-07 -1.52695550653289 5.12596851538943e-24 MirTarget -0.119834307514697 0.00821860657390401 NA NA NA hsa-miR-146b-5p SYNE2 0.419719546795449 0.0457375823220155 -0.596040988930904 1.98484771381191e-05 miRanda -0.14616149824799 6.42908632504195e-06 NA NA NA hsa-miR-21-5p SYNE2 1.51084295924322 1.54551622173259e-34 -0.596040988930904 1.98484771381191e-05 miRNAWalker2_validate -0.267941031650076 1.30549594293723e-07 NA NA NA hsa-miR-455-5p SYNE2 -0.270546034117157 0.0581320703577731 -0.596040988930904 1.98484771381191e-05 miRanda -0.153166247747802 0.00146518371194488 NA NA NA hsa-miR-192-5p SYNGR1 -0.50188499512787 0.00344713341196035 -0.0467874970365392 0.881901328445337 miRNAWalker2_validate -0.468226626727233 1.05709424992985e-07 NA NA NA hsa-miR-215-5p SYNGR1 -0.981544773246509 3.14452272477156e-05 -0.0467874970365392 0.881901328445337 miRNAWalker2_validate -0.19260776556627 0.00276381171984889 NA NA NA hsa-miR-505-5p SYNGR1 -0.768282569967001 1.14662846595407e-05 -0.0467874970365392 0.881901328445337 mirMAP -0.44900100578972 1.65819496912166e-07 NA NA NA hsa-miR-30e-5p SYNGR3 -0.627815042856657 3.02205690184908e-10 0.703275418575047 0.0219868854077355 miRNATAP -0.640783273491562 1.42771371640508e-05 NA NA NA hsa-miR-146b-5p SYNJ2 0.419719546795449 0.0457375823220155 0.152738589872901 0.377287055436838 miRanda -0.121804674465867 0.00232097974592075 NA NA NA hsa-miR-15a-5p SYNPO 0.349521211668244 0.000770735998804736 -0.38693360133088 0.00147471464510177 mirMAP -0.292382939301819 2.67764986405629e-07 NA NA NA hsa-miR-146b-5p SYNPO2 0.419719546795449 0.0457375823220155 -1.63358371067109 5.04985064481196e-15 miRanda -0.138814569164337 0.0055723114706907 NA NA NA hsa-miR-19b-3p SYNPO2 0.601279551368824 0.00016685097085251 -1.63358371067109 5.04985064481196e-15 miRNATAP -0.329892654916284 3.73625105548449e-07 NA NA NA hsa-miR-30c-5p SYP -0.432111642767632 0.000159764714931007 1.11601556044812 6.0544460832658e-08 mirMAP -0.353181867178697 6.85476497249749e-05 NA NA NA hsa-miR-181a-5p SYPL2 0.250113435902954 0.0551933249319293 -1.08471212520328 0.00118696926904982 miRNATAP -0.671089707136944 7.18294129852353e-08 NA NA NA hsa-miR-181b-5p SYPL2 0.488256489401108 0.00105321129419701 -1.08471212520328 0.00118696926904982 miRNATAP -0.724989120687629 1.42076309013101e-11 NA NA NA hsa-miR-34a-5p SYT1 1.03694231790865 5.74864019540594e-14 -0.909227689220105 0.0299110122453997 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.603014777163283 2.54039853678105e-05 NA NA NA hsa-miR-21-5p SYT15 1.51084295924322 1.54551622173259e-34 -0.962117365831715 0.000115018031669002 MirTarget -0.390773797269576 1.79311302132641e-05 NA NA NA hsa-miR-146b-5p SYT2 0.419719546795449 0.0457375823220155 0.802467229345947 0.00243072866414651 mirMAP -0.209917400526542 0.000635413774872252 NA NA NA hsa-miR-15a-5p SYT3 0.349521211668244 0.000770735998804736 1.08585842426938 0.0153893016853133 miRNATAP -0.611951611329026 0.00381198869290846 NA NA NA hsa-miR-146b-5p SYT9 0.419719546795449 0.0457375823220155 -6.06578910970632 3.09724173272226e-32 miRanda -0.45359043576352 0.000415813386150238 NA NA NA hsa-miR-181a-5p SYTL4 0.250113435902954 0.0551933249319293 -0.551448149757261 0.00433260079085029 mirMAP -0.479089273106514 1.64171343563264e-11 NA NA NA hsa-miR-181b-5p SYTL4 0.488256489401108 0.00105321129419701 -0.551448149757261 0.00433260079085029 mirMAP -0.508639223388709 7.61521375975593e-17 NA NA NA hsa-miR-19b-3p SYTL4 0.601279551368824 0.00016685097085251 -0.551448149757261 0.00433260079085029 mirMAP -0.321998908717619 2.95297092440985e-08 NA NA NA hsa-miR-20a-5p SYTL4 0.854326758727003 5.04256669663285e-07 -0.551448149757261 0.00433260079085029 mirMAP -0.338761210687631 3.24403485778431e-10 NA NA NA hsa-miR-20b-5p SYTL4 0.457668023910379 0.0285865211936156 -0.551448149757261 0.00433260079085029 mirMAP -0.144845655433461 0.00130819025817289 NA NA NA hsa-miR-181a-5p TAB2 0.250113435902954 0.0551933249319293 -0.889461263011888 3.1587069991003e-16 miRNAWalker2_validate -0.225006795587249 7.37045773172147e-08 NA NA NA hsa-miR-20a-5p TACC1 0.854326758727003 5.04256669663285e-07 -0.0525566877626078 0.725613334782706 MirTarget -0.276685411340598 2.3182074377097e-11 NA NA NA hsa-miR-181a-5p TADA1 0.250113435902954 0.0551933249319293 0.15524977247706 0.185752192849939 MirTarget -0.125824195105796 0.00415235788945826 NA NA NA hsa-miR-181b-5p TADA1 0.488256489401108 0.00105321129419701 0.15524977247706 0.185752192849939 MirTarget -0.121072709059908 0.00150232332095873 NA NA NA hsa-miR-132-3p TADA2B 0.323796239695997 0.00272093067935091 -0.283647927100808 4.4659054117794e-05 MirTarget -0.153547533461181 8.8745701765007e-07 NA NA NA hsa-miR-21-5p TAF1 1.51084295924322 1.54551622173259e-34 0.0712783642995616 0.555885290313746 miRNAWalker2_validate -0.138574765034134 0.0016161652445308 NA NA NA hsa-miR-29c-3p TAF11 -1.4367517608807 1.61767774905781e-21 0.500426721548112 2.96558065446294e-11 MirTarget -0.207372923405967 3.86664341977037e-20 NA NA NA hsa-miR-148a-3p TAF4B -0.748702855596996 3.93313343865641e-07 -0.601598142975973 0.0171657841614686 MirTarget -0.581392909704103 5.01906359473338e-13 NA NA NA hsa-miR-34a-5p TAF4B 1.03694231790865 5.74864019540594e-14 -0.601598142975973 0.0171657841614686 miRNATAP -0.278473673463303 0.0013224347006827 NA NA NA hsa-miR-455-5p TAF4B -0.270546034117157 0.0581320703577731 -0.601598142975973 0.0171657841614686 miRanda -0.35389735582621 3.96224711111968e-05 NA NA NA hsa-miR-29c-3p TAF5 -1.4367517608807 1.61767774905781e-21 0.389205133880753 4.64864126412305e-06 miRNATAP -0.146759791546038 1.5363854209564e-08 NA NA NA hsa-miR-34a-5p TAF5 1.03694231790865 5.74864019540594e-14 0.389205133880753 4.64864126412305e-06 miRNATAP -0.105642590057024 0.000308585349073346 NA NA NA hsa-miR-181a-5p TAF9B 0.250113435902954 0.0551933249319293 0.0168533538417588 0.873237203791974 MirTarget -0.171201906678251 1.25807517856418e-05 NA NA NA hsa-miR-181b-5p TAF9B 0.488256489401108 0.00105321129419701 0.0168533538417588 0.873237203791974 MirTarget -0.171462062907383 4.47826170178778e-07 NA NA NA hsa-miR-192-3p TAGAP -0.6401165114007 0.000266272092403814 -1.36952624608605 2.73884803345646e-09 MirTarget -0.249464092947114 0.000111982910246531 NA NA NA hsa-miR-20a-5p TANC1 0.854326758727003 5.04256669663285e-07 -0.394105811286722 0.0017117377806427 miRNATAP -0.127964743254188 0.000322164186851975 NA NA NA hsa-miR-455-5p TANC1 -0.270546034117157 0.0581320703577731 -0.394105811286722 0.0017117377806427 miRanda -0.204761351050029 1.66368107189034e-06 NA NA NA hsa-miR-146b-5p TANC2 0.419719546795449 0.0457375823220155 -0.0777608116505228 0.723192087672004 PITA;miRanda;mirMAP;miRNATAP -0.261153583564562 1.99264234145411e-07 NA NA NA hsa-miR-148a-3p TANC2 -0.748702855596996 3.93313343865641e-07 -0.0777608116505228 0.723192087672004 mirMAP -0.620627143687002 1.35989055902964e-19 NA NA NA hsa-miR-17-3p TANC2 0.410352776142368 0.00422200500748636 -0.0777608116505228 0.723192087672004 miRNATAP -0.249384046631639 0.000794589575543029 NA NA NA hsa-miR-20a-5p TANC2 0.854326758727003 5.04256669663285e-07 -0.0777608116505228 0.723192087672004 mirMAP;miRNATAP -0.201667171708266 0.00113912464289227 NA NA NA hsa-miR-34a-5p TANC2 1.03694231790865 5.74864019540594e-14 -0.0777608116505228 0.723192087672004 miRNATAP -0.251980472537603 0.000794827495917416 NA NA NA hsa-miR-15a-5p TAOK1 0.349521211668244 0.000770735998804736 -0.395598965266263 0.0493024563419061 MirTarget -0.235110758226723 0.0132473738345133 NA NA NA hsa-miR-19b-3p TAOK1 0.601279551368824 0.00016685097085251 -0.395598965266263 0.0493024563419061 MirTarget;miRNATAP -0.18747091921372 0.00214646020335936 NA NA NA hsa-miR-20a-5p TAOK1 0.854326758727003 5.04256669663285e-07 -0.395598965266263 0.0493024563419061 miRNATAP -0.188486126469257 0.000927273169437502 NA NA NA hsa-miR-221-3p TAOK1 1.12244756358612 3.48370308238012e-13 -0.395598965266263 0.0493024563419061 miRNATAP -0.15781076312396 0.0108208120585214 NA NA NA hsa-miR-30b-5p TAOK1 -0.54056186708617 2.44688760798341e-05 -0.395598965266263 0.0493024563419061 miRNAWalker2_validate;MirTarget -0.283739212169635 0.000189344321648577 NA NA NA hsa-miR-455-5p TAOK1 -0.270546034117157 0.0581320703577731 -0.395598965266263 0.0493024563419061 MirTarget;miRNATAP -0.296243768029307 1.5142502993155e-05 NA NA NA hsa-miR-182-5p TAPT1 1.96601340710222 4.39326175603633e-09 -1.13334263866931 3.16520734266326e-25 MirTarget;miRNATAP -0.113629238901394 1.7269257769417e-12 NA NA NA hsa-miR-30e-5p TBC1D10B -0.627815042856657 3.02205690184908e-10 0.430421226185847 3.94457058975053e-09 MirTarget -0.103475153879349 0.00382779877295188 NA NA NA hsa-miR-181a-5p TBC1D15 0.250113435902954 0.0551933249319293 -0.632204764840025 2.42607131989069e-23 mirMAP -0.158883704559931 9.15823238542748e-11 NA NA NA hsa-miR-181b-5p TBC1D15 0.488256489401108 0.00105321129419701 -0.632204764840025 2.42607131989069e-23 mirMAP -0.148824312091371 2.43001286802105e-12 NA NA NA hsa-miR-127-3p TBC1D16 -1.0751374948053 2.19322892330221e-05 1.09783247128337 3.62886274986965e-17 miRanda -0.121878233914462 1.87859630808581e-06 NA NA NA hsa-miR-146a-5p TBC1D16 -0.742958238440575 0.000765983177482633 1.09783247128337 3.62886274986965e-17 mirMAP -0.147116467503336 5.78832668572047e-07 NA NA NA hsa-miR-214-5p TBC1D16 -1.91497809567701 3.92955595018147e-12 1.09783247128337 3.62886274986965e-17 mirMAP -0.125938459151686 6.46351089761693e-08 NA NA NA hsa-miR-29c-3p TBC1D16 -1.4367517608807 1.61767774905781e-21 1.09783247128337 3.62886274986965e-17 mirMAP -0.207057786089531 5.19900716390851e-07 NA NA NA hsa-miR-455-3p TBC1D16 -1.3998033821095 5.72010709806871e-17 1.09783247128337 3.62886274986965e-17 mirMAP -0.109024250702277 0.00411574342799913 NA NA NA hsa-miR-192-5p TBC1D22B -0.50188499512787 0.00344713341196035 0.743744466929673 5.16477831720913e-15 miRNAWalker2_validate -0.153036094001149 2.38771328736762e-08 NA NA NA hsa-miR-132-3p TBC1D2B 0.323796239695997 0.00272093067935091 -0.400059050118139 0.00112893124682923 mirMAP -0.187546477867455 0.000767709580738912 NA NA NA hsa-miR-20a-5p TBC1D2B 0.854326758727003 5.04256669663285e-07 -0.400059050118139 0.00112893124682923 mirMAP -0.130138900881065 0.000182172966349087 NA NA NA hsa-miR-29c-3p TBC1D7 -1.4367517608807 1.61767774905781e-21 0.832395630823413 8.80554600633074e-16 MirTarget -0.174023912797499 8.90326263313412e-08 NA NA NA hsa-miR-20a-5p TBC1D8B 0.854326758727003 5.04256669663285e-07 -0.53149570598194 8.91145403097961e-05 MirTarget -0.195787037864496 3.04952109304305e-07 NA NA NA hsa-miR-20a-5p TBC1D9 0.854326758727003 5.04256669663285e-07 -0.444890138943172 0.00365007351651544 miRNATAP -0.318059650839762 4.92411174285087e-14 NA NA NA hsa-miR-27b-3p TBKBP1 -0.823491817819754 9.20935302746823e-14 0.916427652689533 7.35042591752853e-10 miRNATAP -0.281492405872563 1.47022921301917e-05 NA NA NA hsa-miR-181a-5p TBL1X 0.250113435902954 0.0551933249319293 -0.210527078758218 0.0538137802227018 MirTarget;miRNATAP -0.195981076452364 1.31283993255368e-06 NA NA NA hsa-miR-181b-5p TBL1X 0.488256489401108 0.00105321129419701 -0.210527078758218 0.0538137802227018 MirTarget;miRNATAP -0.174048839194183 7.72788457911812e-07 NA NA NA hsa-miR-455-5p TBX18 -0.270546034117157 0.0581320703577731 -0.408500377715692 0.211180893047495 MirTarget;miRanda -0.249395303191083 0.0259635028732391 NA NA NA hsa-miR-20a-5p TBX3 0.854326758727003 5.04256669663285e-07 -0.441002970053455 0.141364740921892 miRNATAP -0.201549871742771 0.0177860685029896 NA NA NA hsa-miR-20b-5p TBX3 0.457668023910379 0.0285865211936156 -0.441002970053455 0.141364740921892 miRNATAP -0.239222380343522 0.000592044423662692 NA NA NA hsa-miR-20a-5p TCEAL1 0.854326758727003 5.04256669663285e-07 0.223569716788717 0.0751012872781512 miRTarBase -0.13411777219916 0.000150865720190614 NA NA NA hsa-miR-34a-5p TCF12 1.03694231790865 5.74864019540594e-14 -0.127454835096152 0.199731397925712 MirTarget;miRNATAP -0.110586526327817 0.00112402729599773 NA NA NA hsa-miR-146b-5p TCF21 0.419719546795449 0.0457375823220155 -2.50041580080969 5.23151011651186e-23 miRanda -0.177902492806139 0.00412295694098634 NA NA NA hsa-miR-21-5p TCF21 1.51084295924322 1.54551622173259e-34 -2.50041580080969 5.23151011651186e-23 miRNAWalker2_validate -0.614038692243697 1.41229606334496e-10 NA NA NA hsa-miR-29c-3p TCF3 -1.4367517608807 1.61767774905781e-21 0.998940019737234 2.89327015478546e-22 mirMAP -0.314602989012805 2.32263523143657e-23 NA NA NA hsa-miR-148a-3p TCF4 -0.748702855596996 3.93313343865641e-07 -0.131793886763984 0.355169273660664 MirTarget;miRNATAP -0.199055475462496 1.6155869003118e-05 NA NA NA hsa-miR-19b-3p TCF4 0.601279551368824 0.00016685097085251 -0.131793886763984 0.355169273660664 miRNAWalker2_validate;mirMAP -0.172115790460859 6.21482066330633e-05 NA NA NA hsa-miR-20a-5p TCF4 0.854326758727003 5.04256669663285e-07 -0.131793886763984 0.355169273660664 miRNATAP -0.198194274703759 6.70106823990996e-07 NA NA NA hsa-miR-455-3p TCF4 -1.3998033821095 5.72010709806871e-17 -0.131793886763984 0.355169273660664 PITA -0.103414110277353 0.00959423694469612 NA NA NA hsa-miR-214-5p TCF7 -1.91497809567701 3.92955595018147e-12 0.316885181039244 0.149291794426295 mirMAP -0.191495267228143 4.22277775127685e-07 NA NA NA hsa-miR-215-5p TCF7 -0.981544773246509 3.14452272477156e-05 0.316885181039244 0.149291794426295 miRNAWalker2_validate;MirTarget -0.173472143860975 0.000107082025354146 NA NA NA hsa-miR-132-3p TCF7L2 0.323796239695997 0.00272093067935091 -0.337137194899186 7.09586898305443e-05 miRNATAP -0.163055557451342 2.13639390460484e-05 NA NA NA hsa-miR-20a-5p TCHH 0.854326758727003 5.04256669663285e-07 -2.31086632807075 2.70172735335336e-20 MirTarget -0.497604794921507 7.86063709665205e-12 NA NA NA hsa-miR-30b-5p TCHP -0.54056186708617 2.44688760798341e-05 0.722322726688777 2.46612499360806e-20 mirMAP -0.10932087193115 0.000395999449616481 NA NA NA hsa-miR-29c-3p TDG -1.4367517608807 1.61767774905781e-21 0.171205758208444 0.0410348183883524 miRNAWalker2_validate;miRTarBase;miRNATAP -0.201876761638725 4.10708656304342e-16 NA NA NA hsa-miR-146b-5p TEAD1 0.419719546795449 0.0457375823220155 -0.19170590497895 0.104550839525967 PITA;miRanda -0.149640399760542 2.80064361620845e-08 NA NA NA hsa-miR-181a-5p TEAD1 0.250113435902954 0.0551933249319293 -0.19170590497895 0.104550839525967 mirMAP;miRNATAP -0.146252843807353 0.000922010692389244 NA NA NA hsa-miR-181b-5p TEAD1 0.488256489401108 0.00105321129419701 -0.19170590497895 0.104550839525967 mirMAP;miRNATAP -0.118713199926625 0.00200784391763121 NA NA NA hsa-miR-19b-3p TEAD1 0.601279551368824 0.00016685097085251 -0.19170590497895 0.104550839525967 mirMAP -0.113967014897005 0.00143123944457348 NA NA NA hsa-miR-20a-5p TEAD1 0.854326758727003 5.04256669663285e-07 -0.19170590497895 0.104550839525967 mirMAP -0.128813035539309 0.000106602332750709 NA NA NA hsa-miR-455-3p TECPR1 -1.3998033821095 5.72010709806871e-17 0.635304351537571 6.77438214834604e-07 mirMAP -0.142506776357872 7.99244786333453e-05 NA NA NA hsa-miR-17-3p TECPR2 0.410352776142368 0.00422200500748636 -0.00190885352482439 0.980406721248931 mirMAP -0.15850634121396 7.62448185769749e-10 NA NA NA hsa-miR-455-5p TEK -0.270546034117157 0.0581320703577731 -2.10076794618928 8.11230955920562e-16 miRanda -0.236378289508641 0.0107994190329021 NA NA NA hsa-miR-21-5p TESK2 1.51084295924322 1.54551622173259e-34 -1.01560084238235 8.87948423764961e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.507273804433523 6.74819091283339e-26 NA NA NA hsa-miR-29c-3p TET1 -1.4367517608807 1.61767774905781e-21 1.01586909495566 6.35204436834337e-06 MirTarget;miRNATAP -0.761225192065957 8.4649970950427e-32 NA NA NA hsa-miR-20a-5p TET2 0.854326758727003 5.04256669663285e-07 -0.51360079629006 6.77317801124857e-06 miRNATAP -0.123533784404676 0.000141599777866497 NA NA NA hsa-miR-455-5p TET2 -0.270546034117157 0.0581320703577731 -0.51360079629006 6.77317801124857e-06 miRanda -0.104094812959821 0.00826055565774 NA NA NA hsa-miR-181a-5p TEX2 0.250113435902954 0.0551933249319293 -0.48823499308155 2.16745539140888e-07 MirTarget -0.136198429860931 0.000129120084909126 NA NA NA hsa-miR-181b-5p TEX2 0.488256489401108 0.00105321129419701 -0.48823499308155 2.16745539140888e-07 MirTarget -0.11796264024551 0.000138251173876437 NA NA NA hsa-miR-455-5p TFAP2A -0.270546034117157 0.0581320703577731 1.04765785650872 0.00261483520532383 miRanda -0.260384677047369 0.0298573058221522 NA NA NA hsa-miR-146b-5p TFCP2L1 0.419719546795449 0.0457375823220155 0.0691205247491691 0.814888444830697 MirTarget -0.14790819659743 0.0307436084364382 NA NA NA hsa-miR-148a-3p TFCP2L1 -0.748702855596996 3.93313343865641e-07 0.0691205247491691 0.814888444830697 mirMAP -0.700020888321756 7.52810321140122e-14 NA NA NA hsa-miR-15a-5p TFCP2L1 0.349521211668244 0.000770735998804736 0.0691205247491691 0.814888444830697 MirTarget -0.391978767321689 0.00475933898843671 NA NA NA hsa-miR-192-3p TFCP2L1 -0.6401165114007 0.000266272092403814 0.0691205247491691 0.814888444830697 mirMAP -0.460791916402403 9.24025491713779e-09 NA NA NA hsa-miR-192-5p TFCP2L1 -0.50188499512787 0.00344713341196035 0.0691205247491691 0.814888444830697 miRNAWalker2_validate -0.433183046361904 1.5634248782453e-07 NA NA NA hsa-miR-30e-5p TFCP2L1 -0.627815042856657 3.02205690184908e-10 0.0691205247491691 0.814888444830697 mirMAP -0.393968729788099 0.00569492401659562 NA NA NA hsa-miR-455-3p TFCP2L1 -1.3998033821095 5.72010709806871e-17 0.0691205247491691 0.814888444830697 mirMAP -0.413535725784514 4.36302384063055e-07 NA NA NA hsa-miR-148a-3p TFEB -0.748702855596996 3.93313343865641e-07 -0.0772531299287356 0.585189118739078 miRNATAP -0.129311975896433 0.0050431934936616 NA NA NA hsa-miR-132-3p TFPI 0.323796239695997 0.00272093067935091 -0.692334589210751 0.00101475366143222 miRNAWalker2_validate -0.255563127209823 0.00776541397340071 NA NA NA hsa-miR-20a-5p TFPI2 0.854326758727003 5.04256669663285e-07 -2.98724706930921 5.09535819315938e-23 miRNATAP -0.494670789290977 3.07715671804473e-08 NA NA NA hsa-miR-148a-3p TFRC -0.748702855596996 3.93313343865641e-07 0.937052448042543 3.46645820917872e-11 miRNATAP -0.216653819308525 3.86635919504837e-06 NA NA NA hsa-miR-148a-3p TGFA -0.748702855596996 3.93313343865641e-07 -2.03762583735332 1.70833612877746e-11 miRNATAP -0.794888513212377 5.2082388955199e-16 NA NA NA hsa-miR-148a-3p TGFB2 -0.748702855596996 3.93313343865641e-07 0.529934214584709 0.036730862150581 MirTarget;miRNATAP -0.661431979951743 1.43220896593668e-16 NA NA NA hsa-miR-19b-3p TGFBR2 0.601279551368824 0.00016685097085251 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRNATAP -0.16137896859351 2.62064707293945e-05 NA NA NA hsa-miR-20a-5p TGFBR2 0.854326758727003 5.04256669663285e-07 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.177394018081005 6.48951647363697e-07 NA NA NA hsa-miR-21-5p TGFBR2 1.51084295924322 1.54551622173259e-34 -0.522706741081292 3.47206054315007e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.236840105633096 2.41705180023436e-07 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-15a-5p TGFBR3 0.349521211668244 0.000770735998804736 -1.53475612080717 2.32211754233392e-15 MirTarget;miRNATAP -0.217345376681276 0.0216565038628408 NA NA NA hsa-miR-181a-5p TGFBR3 0.250113435902954 0.0551933249319293 -1.53475612080717 2.32211754233392e-15 miRNAWalker2_validate;mirMAP;miRNATAP -0.389031034293981 1.71466140133219e-07 NA NA NA hsa-miR-181b-5p TGFBR3 0.488256489401108 0.00105321129419701 -1.53475612080717 2.32211754233392e-15 mirMAP -0.467119604365662 2.30736536364399e-13 NA NA NA hsa-miR-182-5p TGFBR3 1.96601340710222 4.39326175603633e-09 -1.53475612080717 2.32211754233392e-15 miRNATAP -0.183612681218707 5.45847960443815e-11 NA NA NA hsa-miR-21-5p TGFBR3 1.51084295924322 1.54551622173259e-34 -1.53475612080717 2.32211754233392e-15 miRNAWalker2_validate -0.700530304569563 4.67202507056358e-24 NA NA NA hsa-miR-20a-5p TGFBRAP1 0.854326758727003 5.04256669663285e-07 -0.505136451922138 0.0449301720842251 MirTarget -0.168465523858867 0.0184818927101042 NA NA NA hsa-miR-19b-3p TGIF1 0.601279551368824 0.00016685097085251 -0.281520352933841 0.0190080751352769 MirTarget;miRNATAP -0.117036301707622 0.00129940050903918 NA NA NA hsa-miR-148a-3p TGIF2 -0.748702855596996 3.93313343865641e-07 0.183370689181392 0.147188585278003 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.247629083555228 9.91349025355731e-10 26638007 Down Regulation of miR 148a Promotes Metastasis by DNA Methylation and is Associated with Prognosis of Skin Cancer by Targeting TGIF2; The purpose of this study was to investigate the methylation status of miR-148a and its effects on the metastasis and prognosis of skin cancer as well as the interaction with TGIF2 gene; Luciferase reporter assay found that TGIF2 gene was a target gene and its expression was suppressed by miR-148a in skin cancer; CONCLUSIONS Taken together the expression of miR-148a was regulated by DNA methylation and targeted by TGIF2 metastasis;worse prognosis sarcoma hsa-miR-34a-5p TGIF2 1.03694231790865 5.74864019540594e-14 0.183370689181392 0.147188585278003 MirTarget;miRNATAP -0.232858394247066 5.29297273821025e-08 26464633 MicroRNA 34a inhibits tumor invasion and metastasis in gastric cancer by targeting Tgif2; First real-time polymerase chain reaction PCR and western blot analysis were used to analyze the expression of miR-34a and Tgif2 in gastric cancer tissues and the adjacent normal tissues; Next gastric cancer cells were transfected with miR-34a mimic and Tgif2 siRNA respectively; The expression of miR-34a in the adjacent non-tumor tissues was higher than that in gastric cancer tissues but Tgif2 was opposite; In gastric cancer cells transfected with miR-34a mimic/Tgif siRNA Tgif2 expression was remarkably down-regulated; Therefore we concluded that miR-34a could inhibit tumor invasion and metastasis in gastric cancer by targeting Tgif2 and may be a novel therapeutic candidate for gastric cancer metastasis gastric cancer hsa-miR-20a-5p TGM2 0.854326758727003 5.04256669663285e-07 -0.875329681872056 2.87786913171852e-06 MirTarget -0.235089408184339 9.91861947467251e-06 NA NA NA hsa-miR-34a-5p TGM2 1.03694231790865 5.74864019540594e-14 -0.875329681872056 2.87786913171852e-06 miRNAWalker2_validate -0.18393836971424 0.00462220257161869 NA NA NA hsa-miR-19b-3p TGOLN2 0.601279551368824 0.00016685097085251 -0.429830131076565 1.22459702243077e-05 MirTarget;miRNATAP -0.118058619319328 7.91124989703344e-05 NA NA NA hsa-miR-20a-5p TGOLN2 0.854326758727003 5.04256669663285e-07 -0.429830131076565 1.22459702243077e-05 miRNATAP -0.117054523545595 2.65375505523254e-05 NA NA NA hsa-miR-20b-5p TGOLN2 0.457668023910379 0.0285865211936156 -0.429830131076565 1.22459702243077e-05 miRNATAP -0.11133744417616 1.06174353879051e-06 NA NA NA hsa-miR-146b-5p THAP10 0.419719546795449 0.0457375823220155 -0.0110723121414313 0.947375814379163 miRanda -0.132699762777377 0.000606339754373174 NA NA NA hsa-miR-192-5p THBD -0.50188499512787 0.00344713341196035 -1.54895902663437 4.76827970625926e-16 miRNAWalker2_validate -0.239998091360237 1.67811812932913e-05 NA NA NA hsa-miR-19b-3p THBS1 0.601279551368824 0.00016685097085251 -2.1667874641621 3.47909831637717e-17 MirTarget;mirMAP -0.258570375211438 0.00144531729895803 NA NA NA hsa-miR-20a-5p THBS1 0.854326758727003 5.04256669663285e-07 -2.1667874641621 3.47909831637717e-17 miRNAWalker2_validate -0.298190202548282 7.75927048516442e-05 NA NA NA hsa-miR-455-5p THBS1 -0.270546034117157 0.0581320703577731 -2.1667874641621 3.47909831637717e-17 miRanda -0.233762708630074 0.0107946964967754 NA NA NA hsa-miR-20a-5p THBS2 0.854326758727003 5.04256669663285e-07 -0.502816786435579 0.158172197533798 MirTarget -0.441793484244088 1.04186713814831e-05 NA NA NA hsa-miR-455-5p THEMIS -0.270546034117157 0.0581320703577731 -0.987265174716766 9.50186289149555e-05 miRanda -0.252350668086357 0.00381390474128649 NA NA NA hsa-miR-27b-3p THOC3 -0.823491817819754 9.20935302746823e-14 0.399276721087312 1.25813661136998e-05 miRNAWalker2_validate -0.100230624594301 0.0114805247490654 NA NA NA hsa-miR-146a-5p THRB -0.742958238440575 0.000765983177482633 -0.630015828817221 1.00813020178641e-06 MirTarget -0.122982937128459 1.49790140990337e-05 21159845 Direct interaction with THRB was shown for miR-21 and miR-146a thyroid cancer hsa-miR-181a-5p THRB 0.250113435902954 0.0551933249319293 -0.630015828817221 1.00813020178641e-06 MirTarget;mirMAP;miRNATAP -0.296816686469064 6.28267328575448e-10 21159845 We observed lower levels of THRB transcripts in cell lines transfected with miR-21 -146a and -221 down-regulation of 37-48%; P < 0.0001 but not with miR-181a thyroid cancer hsa-miR-181b-5p THRB 0.488256489401108 0.00105321129419701 -0.630015828817221 1.00813020178641e-06 MirTarget;mirMAP;miRNATAP -0.305643512648483 1.46230834503942e-13 NA NA NA hsa-miR-21-5p THRB 1.51084295924322 1.54551622173259e-34 -0.630015828817221 1.00813020178641e-06 MirTarget;miRNATAP -0.466517315998671 2.16976205749556e-25 21159845 Direct interaction with THRB was shown for miR-21 and miR-146a; We observed lower levels of THRB transcripts in cell lines transfected with miR-21 -146a and -221 down-regulation of 37-48%; P < 0.0001 but not with miR-181a; The analysis of tumor/normal tissue pairs revealed down-regulation of THRB in 11 of 13 pairs 1.3- to 9.1-fold and up-regulation of miR-21 -146a -181a and -221 in almost all pairs thyroid cancer hsa-miR-132-3p THSD4 0.323796239695997 0.00272093067935091 -1.03249520260707 2.68769926118397e-05 MirTarget -0.286862472692243 0.0108376230988152 NA NA NA hsa-miR-15a-5p THSD4 0.349521211668244 0.000770735998804736 -1.03249520260707 2.68769926118397e-05 MirTarget -0.392566357996222 0.000762703500983702 NA NA NA hsa-miR-20a-5p THSD4 0.854326758727003 5.04256669663285e-07 -1.03249520260707 2.68769926118397e-05 mirMAP -0.388484475320056 2.07528237316178e-08 NA NA NA hsa-miR-20b-5p THSD4 0.457668023910379 0.0285865211936156 -1.03249520260707 2.68769926118397e-05 mirMAP -0.129721717334266 0.0249721062072934 NA NA NA hsa-miR-455-5p THSD7A -0.270546034117157 0.0581320703577731 0.655648930436568 0.00549610436387998 PITA;miRanda;miRNATAP -0.431117203485401 7.27063838019927e-08 NA NA NA hsa-miR-146b-5p THSD7B 0.419719546795449 0.0457375823220155 -0.750131986999087 0.00627863516706569 miRanda -0.184424297999103 0.00383893217203493 NA NA NA hsa-miR-146b-5p TIAM1 0.419719546795449 0.0457375823220155 -1.56411477781397 6.02866811798354e-13 miRanda -0.181625377721919 0.000441828409003034 NA NA NA hsa-miR-20a-5p TIAM1 0.854326758727003 5.04256669663285e-07 -1.56411477781397 6.02866811798354e-13 MirTarget;miRNATAP -0.146807750673643 0.0206517910606264 NA NA NA hsa-miR-21-5p TIAM1 1.51084295924322 1.54551622173259e-34 -1.56411477781397 6.02866811798354e-13 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.321917397006639 7.35213503545411e-05 20826792 miR 21 and miR 31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells; We present compelling evidence that TIAM1 a guanidine exchange factor of the Rac GTPase is a direct target of both miR-21 and miR-31 colon cancer hsa-miR-221-3p TIAM1 1.12244756358612 3.48370308238012e-13 -1.56411477781397 6.02866811798354e-13 miRNAWalker2_validate -0.281862102724342 3.73338764540275e-05 NA NA NA hsa-miR-455-3p TIFAB -1.3998033821095 5.72010709806871e-17 0.964028681294563 0.000554081418971492 mirMAP -0.378127576871264 1.263684332235e-06 NA NA NA hsa-miR-181a-5p TIMM17A 0.250113435902954 0.0551933249319293 0.343890553338641 0.00122865755696632 MirTarget -0.262632418370694 1.91673127428149e-11 NA NA NA hsa-miR-181b-5p TIMM17A 0.488256489401108 0.00105321129419701 0.343890553338641 0.00122865755696632 MirTarget -0.23910385814719 1.86850502424537e-12 NA NA NA hsa-miR-505-5p TIMM50 -0.768282569967001 1.14662846595407e-05 0.575233750732028 5.54969666641848e-09 MirTarget -0.10111053122127 0.000243710560388608 NA NA NA hsa-miR-192-3p TIMP2 -0.6401165114007 0.000266272092403814 -0.599071024246221 0.00246039513439785 mirMAP -0.502874992812416 5.3377577151289e-22 NA NA NA hsa-miR-20a-5p TIMP2 0.854326758727003 5.04256669663285e-07 -0.599071024246221 0.00246039513439785 miRNATAP -0.205613097275286 0.00024396525545413 25803820 TIMP2 and ATG7 were proved to be direct targets of miR-20a using luciferase assay and western blot; These results indicate that miR-20a suppresses the proliferation migration and invasion of cervical cancer cell through targeting ATG7 and TIMP2 cervical and endocervical cancer hsa-miR-455-5p TIMP2 -0.270546034117157 0.0581320703577731 -0.599071024246221 0.00246039513439785 miRanda -0.209664261052815 0.00201585209435157 NA NA NA hsa-miR-181b-5p TIMP3 0.488256489401108 0.00105321129419701 -0.479569227754572 0.00042274706056242 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.118880966586347 0.0077111895916643 27383203 Moreover miR-181b was found to directly target the 3' untranslated region 3'UTR of Timp3 mRNA affecting TGF-β-induced EMT gastric cancer hsa-miR-20a-5p TIMP3 0.854326758727003 5.04256669663285e-07 -0.479569227754572 0.00042274706056242 miRNATAP -0.209156104661086 4.35176096892657e-08 NA NA NA hsa-miR-21-5p TIMP3 1.51084295924322 1.54551622173259e-34 -0.479569227754572 0.00042274706056242 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.285668268989237 5.87344757554495e-09 25720799;23936642;21820586;20346171;25587717 We verified that HMGB1-induced expression of miR-21 in HCC provides a posttranscriptional repression of the matrix metalloproteinase MMP inhibitors RECK and TIMP3 which are known to impact HCC progression and metastases; Finally we found that inhibition of miR-21 in murine HMGB1-overexpressing HCC xenografts led to reduced tumor MMP activity through released repression of the miR-21 targets RECK and TIMP3 which ultimately impeded tumor progression;Genetic heterogeneity of breast cancer metastasis may be related to miR 21 regulation of TIMP 3 in translation; The aim of this study is to determine whether microRNA-21 miR-21 a specific microRNA implicated in multiple aspects of carcinogenesis promoted breast cancer metastasis by regulating the tissue inhibitor of metalloproteinase 3 TIMP-3 gene; Correlation analysis was performed between miR-21 and TIMP-3; There was significantly inverse correlation between miR-21 and TIMP-3 extracted from tissue;The effect of TIMP3 on miR-21-induced cell survival was determined by transfection with TIMP3 lacking 3' untranslated region and miR-21;The aim of this study was to determine whether microRNA-21 miR-21 a specific microRNA implicated in multiple aspects of carcinogenesis impacts breast cancer invasion by regulating the tissue inhibitor of metalloproteinase 3 TIMP3 gene; In addition the regulation of tissue inhibitor of metalloproteinase 3 TIMP3 by miR-21 was evaluated by western blotting and luciferase assays; Evaluation of TIMP3 protein levels a peptidase involved in extarcellular matrix degredation inversely correlated with miR-21 expression; As knockdown of miR-21 increased TIMP3 protein expression and luciferase reporter activity our data suggests that miR-21 could promote invasion in breast cancer cells via its regulation of TIMP3;It was previously shown by our group that miR-21 a potential regulator of TIMP3 is over-expressed in cutaneous melanoma; It was therefore hypothesized that increased levels of miR-21 expression would lead to decreased expression of TIMP3 and thereby enhance the invasiveness of melanoma cells; Reduced expression of TIMP3 was achieved by siRNA knockdown and significantly enhanced invasion of melanoma cell lines mimicking the effects of miR-21 over-expression; Treatment of tumor cells with a linked nucleic acid antagomir to miR-21 inhibited tumor growth and increased tumor expression of TIMP3 in vivo in 01B74 Athymic NCr-nu/nu mice; This data shows that increased expression of miR-21 enhanced the invasive potential of melanoma cell lines through TIMP3 inhibition metastasis;progression;metastasis;tumorigenesis;poor survival;tumorigenesis; liver cancer;breast cancer;kidney renal cell cancer;breast cancer;melanoma hsa-miR-221-3p TIMP3 1.12244756358612 3.48370308238012e-13 -0.479569227754572 0.00042274706056242 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.144635283598806 0.000555681773778346 27077469 MiR 221 Exacerbate Cell Proliferation and Invasion by Targeting TIMP3 in Papillary Thyroid Carcinoma; The results indicated that miR-221 exacerbated PTC by downregulating the expression of TIMP3; The effects of miR-221 and TIMP3 in vivo were also confirmed by human PTC-bearing mice models which suggest consistent results with those in vitro studies thyroid cancer hsa-miR-222-3p TIMP3 1.08574156066353 1.76407192348131e-11 -0.479569227754572 0.00042274706056242 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.196480024645766 8.49146596783842e-07 NA NA NA hsa-miR-221-3p TIPARP 1.12244756358612 3.48370308238012e-13 -0.956038686169793 4.14382659036917e-16 miRNAWalker2_validate -0.122527915469409 0.0010411994646257 NA NA NA hsa-miR-455-5p TJP1 -0.270546034117157 0.0581320703577731 0.0011791046353169 0.990690010235753 MirTarget;PITA;miRanda;miRNATAP -0.100185345445058 0.00360669959194991 NA NA NA hsa-miR-34a-5p TJP2 1.03694231790865 5.74864019540594e-14 -1.0734182612141 9.84522909368765e-19 miRNAWalker2_validate -0.278771257629492 6.22764876336615e-11 NA NA NA hsa-miR-181b-5p TK2 0.488256489401108 0.00105321129419701 -0.656683086732082 2.72821191142893e-11 mirMAP -0.301318580097334 5.82160181162102e-22 NA NA NA hsa-miR-30c-5p TKT -0.432111642767632 0.000159764714931007 1.10881155846435 8.52116479307873e-10 miRNAWalker2_validate -0.318446623300914 4.60914384305313e-05 NA NA NA hsa-miR-221-3p TLE3 1.12244756358612 3.48370308238012e-13 -0.222524741699439 0.182669026941518 MirTarget;miRNATAP -0.130688892291307 0.0108537727293893 NA NA NA hsa-miR-34a-5p TLE3 1.03694231790865 5.74864019540594e-14 -0.222524741699439 0.182669026941518 miRNAWalker2_validate -0.266131379686652 2.78757093982151e-06 NA NA NA hsa-miR-146b-5p TLE4 0.419719546795449 0.0457375823220155 -0.926422023459501 3.58191158667048e-09 miRanda -0.109219766053241 0.00318212653760745 NA NA NA hsa-miR-15a-5p TLL1 0.349521211668244 0.000770735998804736 -1.05355499497705 1.32450894289782e-05 miRNATAP -0.291130068652071 0.0114482974067222 NA NA NA hsa-miR-455-5p TLL1 -0.270546034117157 0.0581320703577731 -1.05355499497705 1.32450894289782e-05 miRanda -0.277501261106362 0.000882526874134622 NA NA NA hsa-miR-455-5p TLN1 -0.270546034117157 0.0581320703577731 0.0308808520863355 0.704539869379264 miRanda -0.1184767825116 1.67002018370768e-05 NA NA NA hsa-miR-132-3p TLN2 0.323796239695997 0.00272093067935091 -0.356270347574193 0.0423959995051352 miRNAWalker2_validate;miRNATAP -0.201750281304288 0.0113373873573314 NA NA NA hsa-miR-146b-5p TLN2 0.419719546795449 0.0457375823220155 -0.356270347574193 0.0423959995051352 miRNATAP -0.154051227178268 0.000144504579619599 NA NA NA hsa-miR-21-5p TLR4 1.51084295924322 1.54551622173259e-34 -1.6828344992865 2.89483284631908e-26 miRNAWalker2_validate -0.447384108410163 8.62007595677013e-14 27286259 For in vivo relevance expression of TLR4 was correlated with miR-21 expression and ROS production in freshly isolated untreated primary human lung cancer cells lung cancer hsa-miR-127-3p TLX1 -1.0751374948053 2.19322892330221e-05 1.89721341453344 6.19139975978929e-08 miRanda;miRNATAP -0.187654070952479 0.00567390724081629 NA NA NA hsa-miR-20a-5p TM2D2 0.854326758727003 5.04256669663285e-07 -0.658110740005188 1.44619249421993e-09 MirTarget -0.139506870224655 7.42705790412749e-06 NA NA NA hsa-miR-30e-5p TM4SF20 -0.627815042856657 3.02205690184908e-10 2.55912350281616 2.17055605243071e-05 MirTarget -0.877554363216525 0.00282366169276684 NA NA NA hsa-miR-455-5p TM6SF1 -0.270546034117157 0.0581320703577731 -0.370882958378047 0.0359800169372212 miRanda -0.360993438415995 1.33444582281865e-09 NA NA NA hsa-miR-19b-3p TMBIM6 0.601279551368824 0.00016685097085251 -0.8739716428039 2.36157745837239e-20 miRNAWalker2_validate;MirTarget -0.151502805565806 3.44657976150481e-07 NA NA NA hsa-miR-20a-5p TMBIM6 0.854326758727003 5.04256669663285e-07 -0.8739716428039 2.36157745837239e-20 MirTarget -0.158620763573786 9.13566133953307e-09 NA NA NA hsa-miR-20b-5p TMBIM6 0.457668023910379 0.0285865211936156 -0.8739716428039 2.36157745837239e-20 MirTarget -0.121429652225819 9.42120297189768e-08 NA NA NA hsa-miR-30c-5p TMC7 -0.432111642767632 0.000159764714931007 2.03760714579858 4.07529066351364e-21 mirMAP -0.237571803755373 0.0142254060993941 NA NA NA hsa-miR-181a-5p TMCC1 0.250113435902954 0.0551933249319293 -0.104762238614036 0.46647436251659 miRNATAP -0.261494978479182 9.41746100302565e-07 NA NA NA hsa-miR-181b-5p TMCC1 0.488256489401108 0.00105321129419701 -0.104762238614036 0.46647436251659 mirMAP;miRNATAP -0.251994888501966 5.02351949914989e-08 NA NA NA hsa-miR-20a-5p TMCC1 0.854326758727003 5.04256669663285e-07 -0.104762238614036 0.46647436251659 miRNATAP -0.174456732740266 1.56291955192924e-05 NA NA NA hsa-miR-20b-5p TMCC1 0.457668023910379 0.0285865211936156 -0.104762238614036 0.46647436251659 miRNATAP -0.110221992858221 0.000949122088131022 NA NA NA hsa-miR-148a-3p TMCC3 -0.748702855596996 3.93313343865641e-07 0.117668394353186 0.425707008413695 MirTarget -0.155039139325215 0.00125905353152064 NA NA NA hsa-miR-34a-5p TMCC3 1.03694231790865 5.74864019540594e-14 0.117668394353186 0.425707008413695 MirTarget;miRNATAP -0.126760756630473 0.012344364458083 NA NA NA hsa-miR-181a-5p TMED4 0.250113435902954 0.0551933249319293 -0.140492267630687 0.118067623601933 miRNAWalker2_validate -0.100734042231039 0.00269011925500143 NA NA NA hsa-miR-181a-5p TMED5 0.250113435902954 0.0551933249319293 -0.33764879066855 0.00113254692388959 mirMAP;miRNATAP -0.272717361520806 7.09287535353649e-13 NA NA NA hsa-miR-181b-5p TMED5 0.488256489401108 0.00105321129419701 -0.33764879066855 0.00113254692388959 mirMAP -0.24657000908633 7.45058709754898e-14 NA NA NA hsa-miR-181b-5p TMED7 0.488256489401108 0.00105321129419701 -0.253890513639785 0.00735487003225511 miRNAWalker2_validate;miRTarBase -0.178569554619496 4.28085055040639e-09 NA NA NA hsa-miR-221-3p TMED7 1.12244756358612 3.48370308238012e-13 -0.253890513639785 0.00735487003225511 miRNAWalker2_validate;miRTarBase -0.129872834856252 6.87132678664697e-06 NA NA NA hsa-miR-222-3p TMED7 1.08574156066353 1.76407192348131e-11 -0.253890513639785 0.00735487003225511 miRNAWalker2_validate;miRTarBase -0.112285876198078 5.27205008014348e-05 NA NA NA hsa-miR-192-5p TMED8 -0.50188499512787 0.00344713341196035 -0.0859822378570407 0.256018887842563 mirMAP -0.167396847114565 4.28061364398208e-16 NA NA NA hsa-miR-192-5p TMEFF1 -0.50188499512787 0.00344713341196035 1.22531596486822 7.35301173500991e-15 miRNAWalker2_validate -0.322987843255821 6.94230029538015e-13 NA NA NA hsa-miR-215-5p TMEFF1 -0.981544773246509 3.14452272477156e-05 1.22531596486822 7.35301173500991e-15 miRNAWalker2_validate -0.169713306645191 2.65911688327985e-07 NA NA NA hsa-miR-455-3p TMEFF1 -1.3998033821095 5.72010709806871e-17 1.22531596486822 7.35301173500991e-15 MirTarget;PITA -0.118659069017882 0.00945703464679523 NA NA NA hsa-miR-15a-5p TMEM100 0.349521211668244 0.000770735998804736 -2.1394500641308 4.9240669004532e-09 MirTarget -0.502809036527036 0.00417926454605015 NA NA NA hsa-miR-192-5p TMEM106A -0.50188499512787 0.00344713341196035 -0.835180568547328 2.66119460421375e-05 miRNAWalker2_validate -0.138386763607983 0.0150211919278464 NA NA NA hsa-miR-181a-5p TMEM106B 0.250113435902954 0.0551933249319293 -0.291338163502867 0.00199329874426925 MirTarget -0.159354723925483 5.67521937531437e-06 NA NA NA hsa-miR-181b-5p TMEM106B 0.488256489401108 0.00105321129419701 -0.291338163502867 0.00199329874426925 MirTarget -0.112535458370346 0.000243891977534774 NA NA NA hsa-miR-30b-5p TMEM106B -0.54056186708617 2.44688760798341e-05 -0.291338163502867 0.00199329874426925 miRNAWalker2_validate -0.120739033617695 0.000709240569288003 NA NA NA hsa-miR-194-5p TMEM108 -0.292530160992458 0.0996141384876663 0.99389223387558 4.11528829750623e-05 MirTarget -0.379939543917886 9.17813623595709e-09 NA NA NA hsa-miR-17-3p TMEM117 0.410352776142368 0.00422200500748636 0.419604194860961 0.00165040326329788 MirTarget -0.117586207747932 0.00972418837619845 NA NA NA hsa-miR-192-3p TMEM117 -0.6401165114007 0.000266272092403814 0.419604194860961 0.00165040326329788 MirTarget;miRNATAP -0.107805706237652 0.00349895863251326 NA NA NA hsa-miR-455-5p TMEM119 -0.270546034117157 0.0581320703577731 0.504559482847502 0.104910449016493 miRanda -0.454815808514871 1.74130684456284e-05 NA NA NA hsa-miR-148a-3p TMEM120B -0.748702855596996 3.93313343865641e-07 1.34193310296135 3.11902100235044e-43 mirMAP -0.172599931857059 8.02056011224422e-07 NA NA NA hsa-miR-192-3p TMEM120B -0.6401165114007 0.000266272092403814 1.34193310296135 3.11902100235044e-43 mirMAP -0.105400228200427 0.000401239806403455 NA NA NA hsa-miR-181a-5p TMEM123 0.250113435902954 0.0551933249319293 -0.640741116109869 2.31897253373285e-08 MirTarget -0.112070301134851 0.0103529517459543 NA NA NA hsa-miR-17-3p TMEM127 0.410352776142368 0.00422200500748636 -0.0573335513156676 0.30489427729561 mirMAP -0.141847072337257 6.01139222183232e-15 NA NA NA hsa-miR-20a-5p TMEM127 0.854326758727003 5.04256669663285e-07 -0.0573335513156676 0.30489427729561 MirTarget -0.113349061962351 8.70324120705327e-14 NA NA NA hsa-miR-15a-5p TMEM130 0.349521211668244 0.000770735998804736 -0.582637496573184 0.122842329286515 mirMAP -0.481530958984609 0.00681015296390601 NA NA NA hsa-miR-455-5p TMEM130 -0.270546034117157 0.0581320703577731 -0.582637496573184 0.122842329286515 miRanda -0.300364437188307 0.0203615562750471 NA NA NA hsa-miR-29c-3p TMEM132A -1.4367517608807 1.61767774905781e-21 1.86230024554605 3.9469049148942e-14 MirTarget -0.541680105753152 1.25534102871866e-12 NA NA NA hsa-miR-146b-5p TMEM132E 0.419719546795449 0.0457375823220155 -2.57974837771017 3.50652086274908e-16 miRanda -0.170439305703782 0.0254661822245431 NA NA NA hsa-miR-192-5p TMEM136 -0.50188499512787 0.00344713341196035 1.15723298299266 1.09507071750269e-09 miRNAWalker2_validate -0.397818589478256 9.10564201932977e-14 NA NA NA hsa-miR-455-5p TMEM136 -0.270546034117157 0.0581320703577731 1.15723298299266 1.09507071750269e-09 miRanda;miRNATAP -0.239345126528217 0.000294070913247151 NA NA NA hsa-miR-181a-5p TMEM14A 0.250113435902954 0.0551933249319293 0.301048605099102 0.0227620000019524 miRNAWalker2_validate -0.352217255794238 2.99179616435334e-13 NA NA NA hsa-miR-182-5p TMEM150C 1.96601340710222 4.39326175603633e-09 -0.91514940836625 0.00028364789222253 MirTarget -0.245803238576425 3.283329886867e-12 NA NA NA hsa-miR-224-3p TMEM154 1.40770116795301 1.31426607144612e-08 -2.55127196617094 2.61178039289766e-16 mirMAP -0.186119780877792 0.00329261004789918 NA NA NA hsa-miR-19b-3p TMEM159 0.601279551368824 0.00016685097085251 -0.402647235600033 0.0457073835627161 MirTarget;miRNATAP -0.243929618607518 6.25072007886925e-05 NA NA NA hsa-miR-15a-5p TMEM161B 0.349521211668244 0.000770735998804736 -0.0647242131094456 0.518107256135851 MirTarget -0.10382979297472 0.0273153772435107 NA NA NA hsa-miR-192-5p TMEM164 -0.50188499512787 0.00344713341196035 1.2706908651988 7.63591092247221e-16 miRNAWalker2_validate -0.21707054410531 2.27782314707691e-06 NA NA NA hsa-miR-215-5p TMEM164 -0.981544773246509 3.14452272477156e-05 1.2706908651988 7.63591092247221e-16 miRNAWalker2_validate -0.117205283012579 0.000444463338800093 NA NA NA hsa-miR-27b-3p TMEM167A -0.823491817819754 9.20935302746823e-14 0.212640777093779 0.00146514175351927 MirTarget -0.146823135397722 2.28365971146748e-07 NA NA NA hsa-miR-455-5p TMEM167A -0.270546034117157 0.0581320703577731 0.212640777093779 0.00146514175351927 miRanda;miRNATAP -0.104655407437177 3.72362168529572e-06 NA NA NA hsa-miR-29c-3p TMEM169 -1.4367517608807 1.61767774905781e-21 0.766624565833857 1.53953654576761e-05 MirTarget;miRNATAP -0.206203224047917 0.000170523488122244 NA NA NA hsa-miR-182-5p TMEM170B 1.96601340710222 4.39326175603633e-09 -0.28665834823882 0.06540862544437 miRNATAP -0.107170135167115 1.04651604685769e-06 NA NA NA hsa-miR-21-5p TMEM170B 1.51084295924322 1.54551622173259e-34 -0.28665834823882 0.06540862544437 mirMAP -0.438717928720622 1.30887766625303e-15 NA NA NA hsa-miR-30b-5p TMEM170B -0.54056186708617 2.44688760798341e-05 -0.28665834823882 0.06540862544437 MirTarget -0.278125244310968 1.92378096137734e-06 NA NA NA hsa-miR-181a-5p TMEM184C 0.250113435902954 0.0551933249319293 -0.460467378541431 2.71070148754944e-06 MirTarget -0.132459994232067 0.000346772675342257 NA NA NA hsa-miR-181b-5p TMEM184C 0.488256489401108 0.00105321129419701 -0.460467378541431 2.71070148754944e-06 MirTarget -0.123940295368149 0.00011670095304155 NA NA NA hsa-miR-455-5p TMEM185A -0.270546034117157 0.0581320703577731 0.1825130120092 0.068803825631012 miRanda -0.110622473098407 0.00121405447248018 NA NA NA hsa-miR-181a-5p TMEM192 0.250113435902954 0.0551933249319293 -1.02995452969358 8.50907462678487e-17 miRNAWalker2_validate -0.338004633385 6.15961038664055e-13 NA NA NA hsa-miR-29c-3p TMEM198 -1.4367517608807 1.61767774905781e-21 1.11263779262795 9.21291761304099e-09 mirMAP -0.299691277897572 6.00283689062919e-07 NA NA NA hsa-miR-192-5p TMEM200A -0.50188499512787 0.00344713341196035 0.396404896579977 0.139145977799248 miRNAWalker2_validate -0.629992694002355 6.30227581488032e-18 NA NA NA hsa-miR-194-5p TMEM200A -0.292530160992458 0.0996141384876663 0.396404896579977 0.139145977799248 MirTarget -0.64159060297982 8.09754954829427e-20 NA NA NA hsa-miR-30b-5p TMEM209 -0.54056186708617 2.44688760798341e-05 0.457380050867418 6.36152406374587e-08 mirMAP -0.106401790712729 0.00100741148723133 NA NA NA hsa-miR-19b-3p TMEM231 0.601279551368824 0.00016685097085251 -0.959400772868259 7.64741558352663e-06 mirMAP -0.339743442270387 1.74024397988655e-07 NA NA NA hsa-miR-221-3p TMEM25 1.12244756358612 3.48370308238012e-13 -1.8651521520056 8.88146240297357e-13 MirTarget -0.655125853826896 2.01086228648022e-16 NA NA NA hsa-miR-222-3p TMEM25 1.08574156066353 1.76407192348131e-11 -1.8651521520056 8.88146240297357e-13 MirTarget -0.594069579662293 1.0388370918102e-14 NA NA NA hsa-miR-194-5p TMEM26 -0.292530160992458 0.0996141384876663 -2.5197384813827 9.78259484522984e-34 MirTarget -0.296836659909688 1.42311509956603e-06 NA NA NA hsa-miR-224-3p TMEM26 1.40770116795301 1.31426607144612e-08 -2.5197384813827 9.78259484522984e-34 mirMAP -0.252084730514209 7.4800202067195e-09 NA NA NA hsa-miR-181a-5p TMEM27 0.250113435902954 0.0551933249319293 -3.84360762472743 4.36959572638835e-30 MirTarget -0.587618404860726 1.43027370189674e-05 NA NA NA hsa-miR-181b-5p TMEM27 0.488256489401108 0.00105321129419701 -3.84360762472743 4.36959572638835e-30 MirTarget -0.618777407565115 1.28360332681645e-07 NA NA NA hsa-miR-181a-5p TMEM30A 0.250113435902954 0.0551933249319293 -0.622004505169995 5.60466386486971e-15 mirMAP -0.111391366872899 0.000281353838615721 NA NA NA hsa-miR-15a-5p TMEM33 0.349521211668244 0.000770735998804736 -0.23087655274425 0.00504872370251297 MirTarget;miRNATAP -0.114746933955515 0.00302087561282748 NA NA NA hsa-miR-15a-5p TMEM41A 0.349521211668244 0.000770735998804736 -0.0184860327860026 0.814316012850419 MirTarget -0.100180438967831 0.00651809256320169 NA NA NA hsa-miR-194-5p TMEM43 -0.292530160992458 0.0996141384876663 0.0103847757257327 0.898227779450032 MirTarget;miRNATAP -0.201660328730131 1.15310020785252e-21 NA NA NA hsa-miR-19b-3p TMEM45A 0.601279551368824 0.00016685097085251 -2.603351976093 5.44529040887099e-14 miRNAWalker2_validate;MirTarget -0.264538746734794 0.014937028510955 NA NA NA hsa-miR-146b-5p TMEM47 0.419719546795449 0.0457375823220155 -1.6215856228956 1.26274970190329e-13 miRanda -0.136163772182074 0.00927780636148614 NA NA NA hsa-miR-181a-5p TMEM47 0.250113435902954 0.0551933249319293 -1.6215856228956 1.26274970190329e-13 mirMAP -0.301009190881413 0.000363546899669207 NA NA NA hsa-miR-181b-5p TMEM47 0.488256489401108 0.00105321129419701 -1.6215856228956 1.26274970190329e-13 mirMAP -0.347860959288199 1.89046385251935e-06 NA NA NA hsa-miR-19b-3p TMEM47 0.601279551368824 0.00016685097085251 -1.6215856228956 1.26274970190329e-13 miRNATAP -0.499891589700123 6.07598403362296e-14 NA NA NA hsa-miR-409-3p TMEM47 -0.499649792570937 0.0526751181520117 -1.6215856228956 1.26274970190329e-13 PITA -0.124711410500446 0.0033827526124151 NA NA NA hsa-miR-148a-3p TMEM54 -0.748702855596996 3.93313343865641e-07 0.339956153918932 0.165699757140974 MirTarget -0.55222112886462 1.54566938175757e-12 NA NA NA hsa-miR-181a-5p TMEM56 0.250113435902954 0.0551933249319293 -1.75634225549522 4.44536598470124e-19 mirMAP -0.542804832043702 5.40006883662432e-13 NA NA NA hsa-miR-181b-5p TMEM56 0.488256489401108 0.00105321129419701 -1.75634225549522 4.44536598470124e-19 mirMAP -0.609294513803451 1.69608415469662e-21 NA NA NA hsa-miR-20a-5p TMEM56 0.854326758727003 5.04256669663285e-07 -1.75634225549522 4.44536598470124e-19 MirTarget -0.155425344672029 0.00770747316438073 NA NA NA hsa-miR-20b-5p TMEM56 0.457668023910379 0.0285865211936156 -1.75634225549522 4.44536598470124e-19 MirTarget -0.143848843629378 0.00266488774189909 NA NA NA hsa-miR-21-5p TMEM56 1.51084295924322 1.54551622173259e-34 -1.75634225549522 4.44536598470124e-19 miRNAWalker2_validate;mirMAP -0.819689688932153 4.87190400354451e-32 NA NA NA hsa-miR-221-3p TMEM56 1.12244756358612 3.48370308238012e-13 -1.75634225549522 4.44536598470124e-19 mirMAP -0.479846425572342 4.93899541777324e-15 NA NA NA hsa-miR-181a-5p TMEM64 0.250113435902954 0.0551933249319293 -0.00136604960589803 0.993609309009731 miRNAWalker2_validate;MirTarget -0.335759541722176 1.01997439726666e-07 NA NA NA hsa-miR-181b-5p TMEM64 0.488256489401108 0.00105321129419701 -0.00136604960589803 0.993609309009731 MirTarget -0.284246377533529 2.26908648016544e-07 NA NA NA hsa-miR-19b-3p TMEM64 0.601279551368824 0.00016685097085251 -0.00136604960589803 0.993609309009731 miRNATAP -0.192486352592005 0.000185380171305964 NA NA NA hsa-miR-20a-5p TMEM64 0.854326758727003 5.04256669663285e-07 -0.00136604960589803 0.993609309009731 MirTarget;miRNATAP -0.171418847947302 0.000361432121905777 NA NA NA hsa-miR-221-3p TMEM64 1.12244756358612 3.48370308238012e-13 -0.00136604960589803 0.993609309009731 miRNAWalker2_validate -0.120583762709932 0.0213365728251542 NA NA NA hsa-miR-29c-3p TMEM65 -1.4367517608807 1.61767774905781e-21 0.63134880636871 1.29269140897777e-05 MirTarget -0.302820098407083 5.15965879595575e-12 NA NA NA hsa-miR-455-5p TMEM86A -0.270546034117157 0.0581320703577731 -0.317170199070764 0.0163079984467626 PITA;miRanda;miRNATAP -0.20960326152131 2.9536103737293e-06 NA NA NA hsa-miR-455-3p TMEM87A -1.3998033821095 5.72010709806871e-17 0.181512729111779 0.0163661729391364 PITA;miRNATAP -0.114039668786256 4.51793358386377e-08 NA NA NA hsa-miR-148a-3p TMEM9B -0.748702855596996 3.93313343865641e-07 0.0287463993115633 0.684276222499031 miRNAWalker2_validate;miRNATAP -0.115744129064157 3.2275770465905e-07 NA NA NA hsa-miR-181a-5p TMLHE 0.250113435902954 0.0551933249319293 -0.601175322962394 3.92895521860534e-10 MirTarget -0.21896092812466 1.30625536711898e-09 NA NA NA hsa-miR-181b-5p TMLHE 0.488256489401108 0.00105321129419701 -0.601175322962394 3.92895521860534e-10 MirTarget -0.212770502245822 9.38032392376128e-12 NA NA NA hsa-miR-127-3p TMOD1 -1.0751374948053 2.19322892330221e-05 -0.908361389410957 1.39259506269618e-06 miRanda -0.108394086213069 0.00278776453027708 NA NA NA hsa-miR-182-5p TMOD1 1.96601340710222 4.39326175603633e-09 -0.908361389410957 1.39259506269618e-06 miRNATAP -0.10011628697447 0.000214077443846552 NA NA NA hsa-miR-20a-5p TMOD2 0.854326758727003 5.04256669663285e-07 0.273439557141349 0.0664976053061536 mirMAP -0.162530598469261 0.000108983811206762 NA NA NA hsa-miR-30c-5p TMOD2 -0.432111642767632 0.000159764714931007 0.273439557141349 0.0664976053061536 mirMAP;miRNATAP -0.148293982980456 0.0195722140006144 NA NA NA hsa-miR-30e-5p TMOD2 -0.627815042856657 3.02205690184908e-10 0.273439557141349 0.0664976053061536 mirMAP -0.206252431844793 0.00414693609812942 NA NA NA hsa-miR-148a-3p TMSB10 -0.748702855596996 3.93313343865641e-07 0.855988582085651 2.64785852790295e-05 miRNATAP -0.801496222431267 2.12040705537655e-39 NA NA NA hsa-miR-27b-3p TMSB10 -0.823491817819754 9.20935302746823e-14 0.855988582085651 2.64785852790295e-05 miRNATAP -0.315676324207405 0.000347704005746108 NA NA NA hsa-miR-224-3p TMTC1 1.40770116795301 1.31426607144612e-08 -0.480769767034272 0.0187157084560212 mirMAP -0.147947387866484 0.000212656845213608 NA NA NA hsa-miR-192-3p TMTC2 -0.6401165114007 0.000266272092403814 -0.146251758768581 0.50856985156897 MirTarget -0.418350132500968 2.09969315689401e-12 NA NA NA hsa-miR-192-5p TMTC2 -0.50188499512787 0.00344713341196035 -0.146251758768581 0.50856985156897 miRNAWalker2_validate -0.417459076838182 8.968195445829e-12 NA NA NA hsa-miR-27b-3p TMTC2 -0.823491817819754 9.20935302746823e-14 -0.146251758768581 0.50856985156897 MirTarget;miRNATAP -0.293952020200257 0.00198649367928741 NA NA NA hsa-miR-181a-5p TNFAIP1 0.250113435902954 0.0551933249319293 -0.25456481631844 0.00166535803744622 MirTarget -0.207775464800488 2.3054627294729e-12 26152285 Targeting of miR-181a on TNFAIP1 in pancreatic cancer was evaluated by dual-luciferase reporter assay and western blot; The subsequent effects of TNFAIP1 upregulation or down-regulation on miR-181a mediated pancreatic cancer regulation were also evaluated through in vitro proliferation and migration assays; MiR-181a down-regulation inhibited proliferation and migration in vitro and upregulated TNFAIP1 in pancreatic cancer cells; Ectopic TNFAIP1 overexpression had similar tumor-suppressive effects on pancreatic cancer proliferation and migration as miR-181a down-regulation whereas siRNA-mediated TNFAIP1 down-regulation had opposite or oncogenic effects on pancreatic cancer; In vivo pancreatic xenograft showed miR-181a recapitulated the in vitro anti-tumor effects and its regulation on TNFAIP1; MiR-181a played a critical role in regulating pancreatic cancer growth and migration likely interacting with TNFAIP1 pancreatic cancer hsa-miR-181b-5p TNFAIP1 0.488256489401108 0.00105321129419701 -0.25456481631844 0.00166535803744622 MirTarget -0.197231007931395 1.35814831277352e-14 NA NA NA hsa-miR-20a-5p TNFAIP1 0.854326758727003 5.04256669663285e-07 -0.25456481631844 0.00166535803744622 MirTarget -0.104426959927961 4.36585638472708e-06 NA NA NA hsa-miR-21-5p TNFAIP1 1.51084295924322 1.54551622173259e-34 -0.25456481631844 0.00166535803744622 mirMAP -0.134050497609676 4.70645131006535e-06 NA NA NA hsa-miR-455-5p TNFAIP8 -0.270546034117157 0.0581320703577731 -0.297277294066265 0.0654078770525814 miRanda;miRNATAP -0.331779886773743 9.63259788839725e-10 NA NA NA hsa-miR-192-5p TNFRSF11A -0.50188499512787 0.00344713341196035 0.244304748708084 0.307235137168618 mirMAP -0.27584547000856 4.25380209512195e-05 NA NA NA hsa-miR-194-5p TNFRSF11A -0.292530160992458 0.0996141384876663 0.244304748708084 0.307235137168618 mirMAP -0.346070094730865 9.47912461028967e-08 NA NA NA hsa-miR-20a-5p TNFRSF1B 0.854326758727003 5.04256669663285e-07 -0.842653559102565 4.93648097238325e-09 mirMAP -0.158235148112825 0.00013043223392706 NA NA NA hsa-miR-221-3p TNFSF10 1.12244756358612 3.48370308238012e-13 -0.719605061671142 5.12756319214624e-05 miRNAWalker2_validate;miRTarBase -0.279691652886283 2.76653565272805e-07 NA NA NA hsa-miR-222-3p TNFSF10 1.08574156066353 1.76407192348131e-11 -0.719605061671142 5.12756319214624e-05 miRNAWalker2_validate;miRTarBase -0.257653965579585 8.3406120984635e-07 NA NA NA hsa-miR-192-5p TNFSF13 -0.50188499512787 0.00344713341196035 -1.05870744956172 9.5489039983648e-11 miRNAWalker2_validate -0.230987916512773 8.64350878472076e-07 NA NA NA hsa-miR-192-5p TNFSF13B -0.50188499512787 0.00344713341196035 -0.866597065976523 0.000286882542745221 miRNAWalker2_validate -0.342820394368764 3.67666104026941e-07 NA NA NA hsa-miR-505-5p TNFSF15 -0.768282569967001 1.14662846595407e-05 0.585706854566371 0.0463104452610428 MirTarget -0.216932267819916 0.00756876454356844 NA NA NA hsa-miR-455-5p TNFSF8 -0.270546034117157 0.0581320703577731 -0.965054764292008 6.90563544227767e-05 miRanda -0.324933833617193 9.59911420341986e-05 NA NA NA hsa-miR-122-3p TNIK -1.75369011054591 1.52070648599898e-11 -1.30698718080542 2.11831969644423e-06 miRNATAP -0.182017867532971 0.000343625431615326 NA NA NA hsa-miR-455-5p TNIK -0.270546034117157 0.0581320703577731 -1.30698718080542 2.11831969644423e-06 miRanda -0.199352946480659 0.037227170640217 NA NA NA hsa-miR-221-3p TNIP1 1.12244756358612 3.48370308238012e-13 0.0469734113262685 0.641943434956956 miRNAWalker2_validate -0.139797546065847 5.17117232636577e-06 NA NA NA hsa-miR-30c-5p TNIP1 -0.432111642767632 0.000159764714931007 0.0469734113262685 0.641943434956956 mirMAP -0.101474008720889 0.0180021114760948 NA NA NA hsa-miR-148a-3p TNIP2 -0.748702855596996 3.93313343865641e-07 0.335021770072243 5.14349905101051e-05 MirTarget -0.153853270059096 8.46593726591456e-09 NA NA NA hsa-miR-30b-5p TNKS -0.54056186708617 2.44688760798341e-05 0.0955963871876104 0.350681367471954 MirTarget -0.107863568287514 0.00527434982407454 NA NA NA hsa-miR-20a-5p TNKS1BP1 0.854326758727003 5.04256669663285e-07 -0.420431716205674 1.90084489041169e-07 MirTarget;miRNATAP -0.16886938577336 5.04077278422703e-14 NA NA NA hsa-miR-20b-5p TNNI1 0.457668023910379 0.0285865211936156 -0.722976449583672 0.0417802178555415 mirMAP -0.200205684945536 0.0157117331938875 NA NA NA hsa-miR-455-5p TNPO1 -0.270546034117157 0.0581320703577731 -0.00802141246417154 0.909685787476322 MirTarget;PITA;miRanda -0.12675244764523 8.97742803366017e-08 NA NA NA hsa-miR-29c-3p TNRC18 -1.4367517608807 1.61767774905781e-21 0.610142294240987 5.19580615213061e-12 miRNATAP -0.200229295123363 1.39449390542208e-13 NA NA NA hsa-miR-132-3p TNRC6B 0.323796239695997 0.00272093067935091 -0.188109276425255 0.0335580000177885 mirMAP -0.130679668193973 0.00106750581393123 NA NA NA hsa-miR-15a-5p TNRC6B 0.349521211668244 0.000770735998804736 -0.188109276425255 0.0335580000177885 miRNATAP -0.137760278970109 0.000897129123851623 NA NA NA hsa-miR-21-5p TNRC6B 1.51084295924322 1.54551622173259e-34 -0.188109276425255 0.0335580000177885 miRNAWalker2_validate;miRNATAP -0.167703483989802 1.3501746958449e-07 NA NA NA hsa-miR-17-3p TNS1 0.410352776142368 0.00422200500748636 -0.453489796490956 0.000166208939177025 MirTarget -0.106809610277969 0.00946112086217386 NA NA NA hsa-miR-21-5p TNS3 1.51084295924322 1.54551622173259e-34 -0.178816306653718 0.126735298257505 miRNAWalker2_validate -0.17568323830764 3.3969387411453e-05 NA NA NA hsa-miR-182-5p TOB1 1.96601340710222 4.39326175603633e-09 -0.431174885164615 0.0092147974081398 miRNATAP -0.100735609306378 1.79489646113147e-05 NA NA NA hsa-miR-181a-5p TOM1L1 0.250113435902954 0.0551933249319293 -0.380676699923202 0.00715427307906511 MirTarget -0.393154562208586 2.64273704220883e-14 NA NA NA hsa-miR-181b-5p TOM1L1 0.488256489401108 0.00105321129419701 -0.380676699923202 0.00715427307906511 MirTarget -0.365891847865727 2.60556506054188e-16 NA NA NA hsa-miR-29c-3p TOMM20 -1.4367517608807 1.61767774905781e-21 0.593385998783792 6.69647218460373e-11 MirTarget -0.103269633335735 0.000282931891814986 NA NA NA hsa-miR-17-3p TOPORS 0.410352776142368 0.00422200500748636 -0.476181605025169 2.0539555781362e-07 MirTarget -0.137073901494103 1.17478624208958e-05 NA NA NA hsa-miR-21-5p TOPORS 1.51084295924322 1.54551622173259e-34 -0.476181605025169 2.0539555781362e-07 miRNAWalker2_validate -0.26999537294657 1.24551741581356e-16 NA NA NA hsa-miR-17-3p TOR1AIP2 0.410352776142368 0.00422200500748636 -0.337836449293359 0.0591267564574758 mirMAP -0.194015169986915 0.00140579997527062 NA NA NA hsa-miR-181a-5p TOR1AIP2 0.250113435902954 0.0551933249319293 -0.337836449293359 0.0591267564574758 MirTarget -0.277105064006476 3.34409374581573e-05 NA NA NA hsa-miR-181b-5p TOR1AIP2 0.488256489401108 0.00105321129419701 -0.337836449293359 0.0591267564574758 MirTarget -0.217006366520003 0.000193357831475857 NA NA NA hsa-miR-21-5p TOR1AIP2 1.51084295924322 1.54551622173259e-34 -0.337836449293359 0.0591267564574758 mirMAP -0.298788114919202 3.98871752967024e-06 NA NA NA hsa-miR-409-3p TOR1AIP2 -0.499649792570937 0.0526751181520117 -0.337836449293359 0.0591267564574758 mirMAP -0.106223834557649 0.00163664615641758 NA NA NA hsa-miR-192-3p TOX -0.6401165114007 0.000266272092403814 -0.725976975588079 0.0301887887319555 MirTarget;miRNATAP -0.565868962224843 4.93407198896625e-10 NA NA NA hsa-miR-27b-3p TOX -0.823491817819754 9.20935302746823e-14 -0.725976975588079 0.0301887887319555 miRNATAP -0.5483365925563 0.000138835469870354 NA NA NA hsa-miR-30e-5p TOX -0.627815042856657 3.02205690184908e-10 -0.725976975588079 0.0301887887319555 MirTarget -0.374786405586625 0.0209613772310833 NA NA NA hsa-miR-182-5p TOX3 1.96601340710222 4.39326175603633e-09 -0.252236521993092 0.424828745695369 miRNATAP -0.110828500978958 0.0138717386107943 NA NA NA hsa-miR-15a-5p TP53I11 0.349521211668244 0.000770735998804736 0.476046085457397 0.000316558602296656 mirMAP -0.201072487006268 0.00128457974711724 NA NA NA hsa-miR-192-3p TP53I11 -0.6401165114007 0.000266272092403814 0.476046085457397 0.000316558602296656 mirMAP -0.309627204450402 1.43024497524086e-18 NA NA NA hsa-miR-34a-5p TP53I11 1.03694231790865 5.74864019540594e-14 0.476046085457397 0.000316558602296656 mirMAP -0.123881669189898 0.00661561831090209 NA NA NA hsa-miR-146b-5p TP53INP2 0.419719546795449 0.0457375823220155 -0.426300708334499 0.00181395657125895 miRanda -0.11766446562478 0.000201504739236379 NA NA NA hsa-miR-19b-3p TP63 0.601279551368824 0.00016685097085251 0.286977029874556 0.302743474156408 miRNATAP -0.352880887979594 2.66412896696308e-05 NA NA NA hsa-miR-30b-5p TP63 -0.54056186708617 2.44688760798341e-05 0.286977029874556 0.302743474156408 MirTarget;mirMAP -0.277493930761762 0.00853265790427151 NA NA NA hsa-miR-17-3p TPBG 0.410352776142368 0.00422200500748636 -1.15581008833228 0.000118361190977804 miRNATAP -0.432528709309602 2.31096952035359e-05 NA NA NA hsa-miR-148a-3p TPCN1 -0.748702855596996 3.93313343865641e-07 0.601482422409012 3.05338746481423e-08 mirMAP -0.175550226951548 8.36740565092831e-07 NA NA NA hsa-miR-192-5p TPCN1 -0.50188499512787 0.00344713341196035 0.601482422409012 3.05338746481423e-08 mirMAP -0.117465561992072 0.000158835259431966 NA NA NA hsa-miR-192-5p TPM4 -0.50188499512787 0.00344713341196035 0.3605306383464 0.00979481452100365 miRNAWalker2_validate -0.441147882156579 1.54587215893729e-33 NA NA NA hsa-miR-15a-5p TPPP3 0.349521211668244 0.000770735998804736 -0.328575577382825 0.11769956605593 MirTarget;miRNATAP -0.345459267087249 0.00046051002952188 NA NA NA hsa-miR-99a-5p TPPP3 -1.51481656384839 3.93230057259529e-14 -0.328575577382825 0.11769956605593 miRNAWalker2_validate -0.123356056116302 0.0127524881023438 NA NA NA hsa-miR-21-5p TPRG1L 1.51084295924322 1.54551622173259e-34 -0.758883371513601 2.47046358234149e-10 miRNAWalker2_validate;MirTarget -0.319834211135076 1.78076309778345e-13 NA NA NA hsa-miR-20a-5p TRAF3IP2 0.854326758727003 5.04256669663285e-07 -0.495501255758086 0.000506806108002448 mirMAP -0.216942503737222 5.96011703902813e-08 NA NA NA hsa-miR-20b-5p TRAF3IP2 0.457668023910379 0.0285865211936156 -0.495501255758086 0.000506806108002448 mirMAP -0.103369200916444 0.00190035038461118 NA NA NA hsa-miR-192-5p TRAF3IP3 -0.50188499512787 0.00344713341196035 -0.165007606635018 0.391852764417264 miRNAWalker2_validate -0.221747549532359 4.35746573073182e-05 NA NA NA hsa-miR-29c-3p TRAFD1 -1.4367517608807 1.61767774905781e-21 0.226216444993726 0.00443005679697159 miRNATAP -0.119949989662502 6.92732990708237e-07 NA NA NA hsa-miR-215-5p TRAIP -0.981544773246509 3.14452272477156e-05 3.28644450772872 2.26380689657191e-46 miRNAWalker2_validate -0.224740060882462 1.86298731778377e-05 NA NA NA hsa-miR-148a-3p TRAK1 -0.748702855596996 3.93313343865641e-07 0.112414901890156 0.161096546776779 miRNATAP -0.138439950489541 7.44379860540538e-08 NA NA NA hsa-miR-148a-3p TRAK2 -0.748702855596996 3.93313343865641e-07 -0.134753128051574 0.118953684351514 MirTarget;miRNATAP -0.138259168259446 6.72843502340937e-07 NA NA NA hsa-miR-181a-5p TRANK1 0.250113435902954 0.0551933249319293 -1.15202311428733 6.18978510841254e-14 miRNATAP -0.167899844837417 0.00470529371434158 NA NA NA hsa-miR-181b-5p TRANK1 0.488256489401108 0.00105321129419701 -1.15202311428733 6.18978510841254e-14 miRNATAP -0.218942723452318 2.01637324610088e-05 NA NA NA hsa-miR-30e-5p TRAPPC9 -0.627815042856657 3.02205690184908e-10 0.432193249232422 3.28958162188908e-05 miRNAWalker2_validate -0.243212992149371 1.22027672034123e-06 NA NA NA hsa-miR-192-3p TRERF1 -0.6401165114007 0.000266272092403814 -0.366863939887298 0.0331874158506003 MirTarget;miRNATAP -0.373569669711164 4.54917330159182e-16 NA NA NA hsa-miR-192-5p TRERF1 -0.50188499512787 0.00344713341196035 -0.366863939887298 0.0331874158506003 miRNATAP -0.372471969641296 3.43892887381849e-15 NA NA NA hsa-miR-194-5p TRERF1 -0.292530160992458 0.0996141384876663 -0.366863939887298 0.0331874158506003 mirMAP -0.401421568561903 9.58950440519354e-19 NA NA NA hsa-miR-27b-3p TRERF1 -0.823491817819754 9.20935302746823e-14 -0.366863939887298 0.0331874158506003 miRNATAP -0.173842664639369 0.019362567526454 NA NA NA hsa-miR-455-3p TRERF1 -1.3998033821095 5.72010709806871e-17 -0.366863939887298 0.0331874158506003 miRNATAP -0.238449054314324 6.29759085545122e-07 NA NA NA hsa-miR-146b-5p TRHDE 0.419719546795449 0.0457375823220155 -2.08795332024082 1.91110452517853e-05 MirTarget;miRanda -0.268766521040485 0.0188786211554899 NA NA NA hsa-miR-27b-3p TRIL -0.823491817819754 9.20935302746823e-14 0.68492919428511 1.15435507123196e-06 MirTarget -0.153304836819414 0.0125478351411271 NA NA NA hsa-miR-132-3p TRIM2 0.323796239695997 0.00272093067935091 -0.669569001903942 0.000204730952595103 miRNATAP -0.287524751344561 0.000457157547799473 NA NA NA hsa-miR-15a-5p TRIM2 0.349521211668244 0.000770735998804736 -0.669569001903942 0.000204730952595103 miRNATAP -0.205522325904107 0.0163051585106428 NA NA NA hsa-miR-181a-5p TRIM2 0.250113435902954 0.0551933249319293 -0.669569001903942 0.000204730952595103 miRNAWalker2_validate;miRNATAP -0.345749547882104 2.81858196671245e-07 NA NA NA hsa-miR-181b-5p TRIM2 0.488256489401108 0.00105321129419701 -0.669569001903942 0.000204730952595103 miRNATAP -0.320204860240171 4.27516868705967e-08 NA NA NA hsa-miR-19b-3p TRIM2 0.601279551368824 0.00016685097085251 -0.669569001903942 0.000204730952595103 miRNAWalker2_validate -0.34446001900045 1.83786395925928e-10 NA NA NA hsa-miR-21-5p TRIM2 1.51084295924322 1.54551622173259e-34 -0.669569001903942 0.000204730952595103 miRNAWalker2_validate;mirMAP;miRNATAP -0.360649471365021 3.33786514044469e-08 NA NA NA hsa-miR-409-3p TRIM2 -0.499649792570937 0.0526751181520117 -0.669569001903942 0.000204730952595103 PITA;mirMAP -0.174652149286305 2.46898726038421e-07 NA NA NA hsa-miR-455-5p TRIM2 -0.270546034117157 0.0581320703577731 -0.669569001903942 0.000204730952595103 miRanda -0.256567056394717 3.26672654235684e-05 NA NA NA hsa-miR-27b-3p TRIM21 -0.823491817819754 9.20935302746823e-14 -0.16414063988104 0.114603639312823 MirTarget -0.11971312668288 0.00739964740946908 NA NA NA hsa-miR-455-5p TRIM22 -0.270546034117157 0.0581320703577731 -1.25585838559432 1.47478296008739e-08 miRanda -0.362928262900505 2.13012928349028e-06 NA NA NA hsa-miR-132-3p TRIM23 0.323796239695997 0.00272093067935091 -0.298910242960821 0.000941811896082851 miRNAWalker2_validate -0.188440677646714 3.6272307565521e-06 NA NA NA hsa-miR-181a-5p TRIM23 0.250113435902954 0.0551933249319293 -0.298910242960821 0.000941811896082851 mirMAP -0.228322870660361 5.73873562329345e-12 NA NA NA hsa-miR-181b-5p TRIM23 0.488256489401108 0.00105321129419701 -0.298910242960821 0.000941811896082851 mirMAP -0.216531365304488 4.3635143453713e-14 NA NA NA hsa-miR-455-5p TRIM23 -0.270546034117157 0.0581320703577731 -0.298910242960821 0.000941811896082851 miRNAWalker2_validate;miRNATAP -0.117415533740706 0.000141114790332709 NA NA NA hsa-miR-132-3p TRIM26 0.323796239695997 0.00272093067935091 -0.0258263759150745 0.748036660502722 MirTarget -0.230380171685405 8.35766945646481e-11 NA NA NA hsa-miR-505-5p TRIM28 -0.768282569967001 1.14662846595407e-05 0.651853250493276 7.91407664709318e-12 miRNAWalker2_validate -0.114299536621946 1.91055847307726e-05 NA NA NA hsa-miR-181a-5p TRIM35 0.250113435902954 0.0551933249319293 -0.908312943568019 1.50923347465387e-09 mirMAP -0.328292200461751 6.65163168657943e-09 NA NA NA hsa-miR-181b-5p TRIM35 0.488256489401108 0.00105321129419701 -0.908312943568019 1.50923347465387e-09 mirMAP -0.353586132758614 3.81031711319792e-13 NA NA NA hsa-miR-20a-5p TRIM36 0.854326758727003 5.04256669663285e-07 0.114048335730387 0.617831221674831 MirTarget;miRNATAP -0.266178362356448 3.47005917848808e-05 NA NA NA hsa-miR-29c-3p TRIM37 -1.4367517608807 1.61767774905781e-21 0.505705876409016 2.91553461671614e-08 miRNATAP -0.163072647507692 5.61980421282616e-09 NA NA NA hsa-miR-222-3p TRIM44 1.08574156066353 1.76407192348131e-11 -0.690095272813942 2.68648252061351e-08 miRNAWalker2_validate -0.149204533958374 5.43585546862838e-05 NA NA NA hsa-miR-455-5p TRIM44 -0.270546034117157 0.0581320703577731 -0.690095272813942 2.68648252061351e-08 miRanda -0.197226707933672 4.03258970219761e-06 NA NA NA hsa-miR-455-5p TRIM46 -0.270546034117157 0.0581320703577731 1.27101173214972 7.40127158592628e-10 miRanda;miRNATAP -0.143843330183542 0.0466771191970376 NA NA NA hsa-miR-148a-3p TRIM59 -0.748702855596996 3.93313343865641e-07 1.7356935499647 4.96522875209022e-19 miRNAWalker2_validate;MirTarget -0.530631145085023 1.38548428892168e-16 NA NA NA hsa-miR-192-5p TRIM59 -0.50188499512787 0.00344713341196035 1.7356935499647 4.96522875209022e-19 miRNAWalker2_validate -0.243147327759177 2.25863404843399e-05 NA NA NA hsa-miR-132-3p TRIM66 0.323796239695997 0.00272093067935091 0.807068904444835 4.08730410631591e-10 mirMAP -0.144816543110047 0.0154409816496244 NA NA NA hsa-miR-192-5p TRIM67 -0.50188499512787 0.00344713341196035 0.526474972444801 0.0261906603203476 mirMAP -0.293477263472278 1.09731353779698e-05 NA NA NA hsa-miR-27b-3p TRIM67 -0.823491817819754 9.20935302746823e-14 0.526474972444801 0.0261906603203476 mirMAP -0.232021312153903 0.0233250108376052 NA NA NA hsa-miR-29c-3p TRIM67 -1.4367517608807 1.61767774905781e-21 0.526474972444801 0.0261906603203476 mirMAP -0.231476629102388 0.00148816535868706 NA NA NA hsa-miR-20a-5p TRIP11 0.854326758727003 5.04256669663285e-07 -0.200994211822031 0.0443801393217673 miRNATAP -0.124161375309083 9.61909880244207e-06 NA NA NA hsa-miR-192-5p TRIP13 -0.50188499512787 0.00344713341196035 3.40696055788158 8.8617706442272e-44 miRNAWalker2_validate -0.323478417816599 2.76454108833635e-05 NA NA NA hsa-miR-215-5p TRIP13 -0.981544773246509 3.14452272477156e-05 3.40696055788158 8.8617706442272e-44 miRNAWalker2_validate -0.23479027343258 2.52625886117563e-05 NA NA NA hsa-miR-215-5p TROAP -0.981544773246509 3.14452272477156e-05 4.26965101571361 1.86376182702341e-47 miRNAWalker2_validate -0.174002808494368 0.0105807023323345 NA NA NA hsa-miR-192-5p TRPC1 -0.50188499512787 0.00344713341196035 0.308490971924318 0.14555420535354 miRNAWalker2_validate -0.348058000322841 3.86230960675937e-09 NA NA NA hsa-miR-215-5p TRPC1 -0.981544773246509 3.14452272477156e-05 0.308490971924318 0.14555420535354 miRNAWalker2_validate -0.185704400540967 1.64160806954841e-05 NA NA NA hsa-miR-21-5p TRPM7 1.51084295924322 1.54551622173259e-34 -0.386704410514037 0.00191776856143715 miRNAWalker2_validate;miRNATAP -0.364353905234612 1.1645509151234e-16 NA NA NA hsa-miR-30b-5p TRPM7 -0.54056186708617 2.44688760798341e-05 -0.386704410514037 0.00191776856143715 MirTarget -0.103375594489593 0.0293027361608508 NA NA NA hsa-miR-148a-3p TRPS1 -0.748702855596996 3.93313343865641e-07 0.234327311753334 0.28887714546093 miRNATAP -0.232765974533109 0.00122300098269749 NA NA NA hsa-miR-194-5p TRPS1 -0.292530160992458 0.0996141384876663 0.234327311753334 0.28887714546093 MirTarget;miRNATAP -0.194515373155686 0.00131102127495661 NA NA NA hsa-miR-19b-3p TRPS1 0.601279551368824 0.00016685097085251 0.234327311753334 0.28887714546093 mirMAP;miRNATAP -0.166773828660623 0.0129357829998983 NA NA NA hsa-miR-455-3p TRPS1 -1.3998033821095 5.72010709806871e-17 0.234327311753334 0.28887714546093 miRNATAP -0.28169972631544 4.53489703160503e-06 NA NA NA hsa-miR-455-5p TRPS1 -0.270546034117157 0.0581320703577731 0.234327311753334 0.28887714546093 MirTarget;PITA;miRanda;miRNATAP -0.41247059553637 3.13696965680738e-08 NA NA NA hsa-miR-20a-5p TRPV6 0.854326758727003 5.04256669663285e-07 -4.08292783556857 1.32667949131395e-19 miRNATAP -0.60668935528315 4.90662685916048e-06 NA NA NA hsa-miR-181a-5p TSC22D2 0.250113435902954 0.0551933249319293 -1.12090763359319 2.22265538164126e-16 MirTarget -0.192922536607501 0.000271551244412174 NA NA NA hsa-miR-181b-5p TSC22D2 0.488256489401108 0.00105321129419701 -1.12090763359319 2.22265538164126e-16 MirTarget -0.196034968115083 1.99198917257437e-05 NA NA NA hsa-miR-221-3p TSC22D2 1.12244756358612 3.48370308238012e-13 -1.12090763359319 2.22265538164126e-16 miRNAWalker2_validate -0.204958960929289 2.04978297616466e-06 NA NA NA hsa-miR-132-3p TSC22D3 0.323796239695997 0.00272093067935091 -0.6453644517172 0.00313634285713395 miRNATAP -0.197259595978604 0.0477062411745543 NA NA NA hsa-miR-182-5p TSC22D3 1.96601340710222 4.39326175603633e-09 -0.6453644517172 0.00313634285713395 miRNAWalker2_validate;miRNATAP -0.104952235044808 0.000760679055429719 NA NA NA hsa-miR-19b-3p TSC22D3 0.601279551368824 0.00016685097085251 -0.6453644517172 0.00313634285713395 miRNAWalker2_validate -0.251574851369585 0.000148660698983504 NA NA NA hsa-miR-455-3p TSC22D4 -1.3998033821095 5.72010709806871e-17 0.377362227182363 0.000323388209110541 miRNAWalker2_validate -0.106653496295048 0.000292891450470832 NA NA NA hsa-miR-21-5p TSHZ1 1.51084295924322 1.54551622173259e-34 -0.489626961191658 7.53435228390986e-07 miRNATAP -0.312475230791863 3.84129485458031e-19 NA NA NA hsa-miR-30c-5p TSHZ2 -0.432111642767632 0.000159764714931007 -0.91719022212394 0.000244558346636778 mirMAP -0.235063060035163 0.0286277548783987 NA NA NA hsa-miR-17-3p TSHZ3 0.410352776142368 0.00422200500748636 -0.769757153572753 6.19298715512245e-06 MirTarget;miRNATAP -0.269981602717962 3.2168865234587e-06 NA NA NA hsa-miR-192-3p TSHZ3 -0.6401165114007 0.000266272092403814 -0.769757153572753 6.19298715512245e-06 MirTarget;miRNATAP -0.428155498034576 3.21594025027486e-21 NA NA NA hsa-miR-19b-3p TSHZ3 0.601279551368824 0.00016685097085251 -0.769757153572753 6.19298715512245e-06 MirTarget;miRNATAP -0.241845487150345 3.0400778827066e-06 NA NA NA hsa-miR-20a-5p TSHZ3 0.854326758727003 5.04256669663285e-07 -0.769757153572753 6.19298715512245e-06 MirTarget;miRNATAP -0.292148188322042 1.04807086484758e-09 NA NA NA hsa-miR-455-3p TSHZ3 -1.3998033821095 5.72010709806871e-17 -0.769757153572753 6.19298715512245e-06 PITA;miRNATAP -0.178092987315597 0.000212800031599638 NA NA NA hsa-miR-455-5p TSHZ3 -0.270546034117157 0.0581320703577731 -0.769757153572753 6.19298715512245e-06 MirTarget;PITA;miRanda;miRNATAP -0.299319370494784 2.7533402444665e-07 NA NA NA hsa-miR-182-5p TSKU 1.96601340710222 4.39326175603633e-09 -1.30603627474332 1.4046551833908e-06 miRNATAP -0.29507965223203 6.40177756908263e-15 NA NA NA hsa-miR-432-5p TSKU -0.536178819038888 0.0748623258271085 -1.30603627474332 1.4046551833908e-06 mirMAP -0.158384331201218 0.000354216509691685 NA NA NA hsa-miR-34a-5p TSPAN11 1.03694231790865 5.74864019540594e-14 -2.03267887917473 8.60115528470112e-13 mirMAP -0.2929737988687 0.00353123604679875 NA NA NA hsa-miR-455-5p TSPAN11 -0.270546034117157 0.0581320703577731 -2.03267887917473 8.60115528470112e-13 mirMAP -0.208503764357361 0.0377613006025998 NA NA NA hsa-miR-455-3p TSPAN18 -1.3998033821095 5.72010709806871e-17 0.0414923398388827 0.790002401549476 miRNATAP -0.100323971846494 0.0216075792676743 NA NA NA hsa-miR-192-5p TSPAN3 -0.50188499512787 0.00344713341196035 0.0573084342867682 0.616032989656141 mirMAP -0.194699849091232 8.17946134781559e-10 NA NA NA hsa-miR-455-3p TSPAN32 -1.3998033821095 5.72010709806871e-17 -0.167958516507478 0.418035052583983 miRNATAP -0.175455988649833 0.00251088039775282 NA NA NA hsa-miR-20a-5p TSPAN5 0.854326758727003 5.04256669663285e-07 0.521509853347309 0.137106034516152 mirMAP -0.360911157856223 0.000268598415972188 NA NA NA hsa-miR-455-5p TSPAN5 -0.270546034117157 0.0581320703577731 0.521509853347309 0.137106034516152 MirTarget;miRNATAP -0.360575394473992 0.0026604469140073 NA NA NA hsa-miR-132-3p TSPAN6 0.323796239695997 0.00272093067935091 -0.337366333760285 0.00623756815620671 miRNAWalker2_validate -0.270851973593222 1.03710393940905e-06 NA NA NA hsa-miR-182-5p TSPAN9 1.96601340710222 4.39326175603633e-09 -0.768876967637944 2.01575911342252e-11 MirTarget;miRNATAP -0.10019508029085 1.0726424922496e-09 NA NA NA hsa-miR-20a-5p TSPYL5 0.854326758727003 5.04256669663285e-07 -1.77057901747748 4.6912848761307e-17 mirMAP -0.335016051284729 4.76732203816453e-08 NA NA NA hsa-miR-181a-5p TTBK1 0.250113435902954 0.0551933249319293 -0.828139372024007 0.00392617205238364 miRNATAP -0.229618321740625 0.034061194273121 NA NA NA hsa-miR-181b-5p TTBK1 0.488256489401108 0.00105321129419701 -0.828139372024007 0.00392617205238364 miRNATAP -0.298968230844976 0.00145777554039975 NA NA NA hsa-miR-146b-5p TTBK2 0.419719546795449 0.0457375823220155 -0.531323848038153 0.00119216636738993 mirMAP -0.118606404448443 0.00185530319855221 NA NA NA hsa-miR-34a-5p TTC19 1.03694231790865 5.74864019540594e-14 -0.747524552298525 5.12931843880723e-13 MirTarget;miRNATAP -0.159896702899957 1.02982271296335e-05 NA NA NA hsa-miR-30b-5p TTC30A -0.54056186708617 2.44688760798341e-05 -0.19242026544065 0.136374929332721 mirMAP -0.198156739175681 4.57503297017565e-05 NA NA NA hsa-miR-21-5p TTC33 1.51084295924322 1.54551622173259e-34 -0.109909665894112 0.210986735501256 miRNAWalker2_validate -0.195027613607619 4.74386595104879e-10 NA NA NA hsa-miR-146b-5p TTC39A 0.419719546795449 0.0457375823220155 2.64467452765163 1.3333642353103e-14 miRanda -0.169233592102463 0.0402138343755084 NA NA NA hsa-miR-192-3p TTC39A -0.6401165114007 0.000266272092403814 2.64467452765163 1.3333642353103e-14 mirMAP -0.565445268421723 4.73403222840762e-09 NA NA NA hsa-miR-27b-3p TTC39A -0.823491817819754 9.20935302746823e-14 2.64467452765163 1.3333642353103e-14 mirMAP -0.650911024455246 1.85447564392055e-05 NA NA NA hsa-miR-15a-5p TTC39B 0.349521211668244 0.000770735998804736 -1.71973555703333 1.52777146203724e-14 MirTarget -0.340405151206748 0.00176090208067026 NA NA NA hsa-miR-181a-5p TTC39B 0.250113435902954 0.0551933249319293 -1.71973555703333 1.52777146203724e-14 MirTarget;miRNATAP -0.313607709475092 0.000289513358654305 NA NA NA hsa-miR-181b-5p TTC39B 0.488256489401108 0.00105321129419701 -1.71973555703333 1.52777146203724e-14 MirTarget;miRNATAP -0.345269823928293 4.03390575882277e-06 NA NA NA hsa-miR-17-3p TTC9 0.410352776142368 0.00422200500748636 1.33647962627701 1.22234162293908e-06 miRNATAP -0.79663632168768 2.10724544338013e-18 NA NA NA hsa-miR-19b-3p TTC9 0.601279551368824 0.00016685097085251 1.33647962627701 1.22234162293908e-06 miRNATAP -0.667953021658632 3.24357140621413e-16 NA NA NA hsa-miR-20a-5p TTC9 0.854326758727003 5.04256669663285e-07 1.33647962627701 1.22234162293908e-06 miRNATAP -0.584639517192676 2.46906403320725e-14 NA NA NA hsa-miR-20b-5p TTC9 0.457668023910379 0.0285865211936156 1.33647962627701 1.22234162293908e-06 miRNATAP -0.214374814245962 0.000941766709084888 NA NA NA hsa-miR-30c-5p TTC9 -0.432111642767632 0.000159764714931007 1.33647962627701 1.22234162293908e-06 mirMAP -0.355045377118883 0.00278825262432957 NA NA NA hsa-miR-30e-5p TTC9 -0.627815042856657 3.02205690184908e-10 1.33647962627701 1.22234162293908e-06 mirMAP -0.532786280246677 7.14373607857834e-05 NA NA NA hsa-miR-192-5p TTF2 -0.50188499512787 0.00344713341196035 1.03578447746635 1.88065403311168e-12 miRNAWalker2_validate -0.208281845740539 8.99265624074137e-07 NA NA NA hsa-miR-215-5p TTF2 -0.981544773246509 3.14452272477156e-05 1.03578447746635 1.88065403311168e-12 miRNAWalker2_validate -0.101230673755716 0.00104216339602549 NA NA NA hsa-miR-215-5p TTK -0.981544773246509 3.14452272477156e-05 4.46695225538541 3.90954998066403e-48 miRNAWalker2_validate -0.154558614985227 0.0292381161076613 NA NA NA hsa-miR-455-3p TTK -1.3998033821095 5.72010709806871e-17 4.46695225538541 3.90954998066403e-48 miRNATAP -0.457661482122706 1.91508543926432e-06 NA NA NA hsa-miR-181a-5p TTLL7 0.250113435902954 0.0551933249319293 -0.174209860799301 0.581064288483948 MirTarget -0.468471605433407 6.94009375860676e-05 NA NA NA hsa-miR-181b-5p TTLL7 0.488256489401108 0.00105321129419701 -0.174209860799301 0.581064288483948 MirTarget -0.367587805517535 0.000340744906703221 NA NA NA hsa-miR-20a-5p TTLL7 0.854326758727003 5.04256669663285e-07 -0.174209860799301 0.581064288483948 mirMAP -0.3261995488826 0.00024800581064627 NA NA NA hsa-miR-455-5p TTLL7 -0.270546034117157 0.0581320703577731 -0.174209860799301 0.581064288483948 miRanda -0.728808968444109 4.73301055069921e-12 NA NA NA hsa-miR-17-3p TTPA 0.410352776142368 0.00422200500748636 -1.89717205654117 8.98711073774743e-09 MirTarget -0.309186775014645 0.00681421821817298 NA NA NA hsa-miR-122-3p TTYH3 -1.75369011054591 1.52070648599898e-11 0.770555614902691 1.06180020960171e-06 mirMAP -0.188749485244053 4.09052247159615e-11 NA NA NA hsa-miR-148a-3p TTYH3 -0.748702855596996 3.93313343865641e-07 0.770555614902691 1.06180020960171e-06 mirMAP -0.336909304109069 4.30253872401559e-11 NA NA NA hsa-miR-192-5p TTYH3 -0.50188499512787 0.00344713341196035 0.770555614902691 1.06180020960171e-06 mirMAP -0.229547107590934 2.97485668658504e-07 NA NA NA hsa-miR-27b-3p TTYH3 -0.823491817819754 9.20935302746823e-14 0.770555614902691 1.06180020960171e-06 miRNATAP -0.302565000871573 9.53937852045108e-06 NA NA NA hsa-miR-455-3p TTYH3 -1.3998033821095 5.72010709806871e-17 0.770555614902691 1.06180020960171e-06 mirMAP -0.112542868658964 0.0121279824937511 NA NA NA hsa-miR-29c-3p TUBB2A -1.4367517608807 1.61767774905781e-21 0.118209924765712 0.481108277074508 MirTarget;miRNATAP -0.200892995910453 8.99048142081535e-05 NA NA NA hsa-miR-29c-3p TUBB2B -1.4367517608807 1.61767774905781e-21 0.295467774255719 0.278138608826702 MirTarget;miRNATAP -0.338221257860993 4.94048293689684e-05 NA NA NA hsa-miR-29c-3p TUBD1 -1.4367517608807 1.61767774905781e-21 0.385254551702268 3.19507055886987e-05 MirTarget -0.246536974900602 2.61001864653802e-19 NA NA NA hsa-miR-99a-5p TUBG1 -1.51481656384839 3.93230057259529e-14 1.00556069919065 4.65567257361525e-21 miRNAWalker2_validate -0.148761289252258 1.08141477935516e-08 NA NA NA hsa-miR-181a-5p TUSC1 0.250113435902954 0.0551933249319293 -1.26160510206614 3.36710589850763e-09 miRNAWalker2_validate -0.193524097825664 0.0178588082773973 NA NA NA hsa-miR-194-5p TUSC3 -0.292530160992458 0.0996141384876663 -0.96167849477842 0.00399152213811475 MirTarget -0.681324512186601 2.49019429043628e-14 NA NA NA hsa-miR-455-5p TUSC3 -0.270546034117157 0.0581320703577731 -0.96167849477842 0.00399152213811475 miRanda -0.600040482841267 1.21634918459781e-07 NA NA NA hsa-miR-30b-5p TXLNG -0.54056186708617 2.44688760798341e-05 -0.38595475885819 0.0738924180655108 mirMAP -0.226479981718397 0.00566134924688827 NA NA NA hsa-miR-20a-5p TXNIP 0.854326758727003 5.04256669663285e-07 -1.09755600933445 1.08530493651829e-08 MirTarget -0.149396599341359 0.00695907025602225 NA NA NA hsa-miR-34a-5p TXNIP 1.03694231790865 5.74864019540594e-14 -1.09755600933445 1.08530493651829e-08 miRNAWalker2_validate -0.240634797184267 0.000321149278429377 NA NA NA hsa-miR-181a-5p TXNL1 0.250113435902954 0.0551933249319293 0.0602068041488337 0.485867472102786 mirMAP -0.151257400569865 2.20400378269351e-06 NA NA NA hsa-miR-181b-5p TXNL1 0.488256489401108 0.00105321129419701 0.0602068041488337 0.485867472102786 mirMAP -0.115923810113945 3.21073234136468e-05 NA NA NA hsa-miR-194-5p TYMS -0.292530160992458 0.0996141384876663 1.73887296208296 3.38348708195271e-19 miRNAWalker2_validate -0.117867394932888 0.0350280900659813 NA NA NA hsa-miR-99a-5p TYMS -1.51481656384839 3.93230057259529e-14 1.73887296208296 3.38348708195271e-19 miRNAWalker2_validate -0.32284017481856 5.05739555088123e-12 NA NA NA hsa-miR-99a-5p UBA2 -1.51481656384839 3.93230057259529e-14 0.264033483753511 0.000646839149305904 miRNAWalker2_validate -0.122133511729424 7.17458571335952e-12 NA NA NA hsa-miR-148a-3p UBASH3B -0.748702855596996 3.93313343865641e-07 -0.366176880641331 0.0811617780784009 MirTarget -0.844727394486042 1.96609914042261e-42 NA NA NA hsa-miR-192-3p UBASH3B -0.6401165114007 0.000266272092403814 -0.366176880641331 0.0811617780784009 mirMAP -0.543514399951535 5.08353942933072e-23 NA NA NA hsa-miR-192-5p UBASH3B -0.50188499512787 0.00344713341196035 -0.366176880641331 0.0811617780784009 miRNAWalker2_validate -0.600320995326487 6.37528716374657e-27 NA NA NA hsa-miR-215-5p UBASH3B -0.981544773246509 3.14452272477156e-05 -0.366176880641331 0.0811617780784009 miRNAWalker2_validate -0.112625420497695 0.00883919213498256 NA NA NA hsa-miR-27b-3p UBASH3B -0.823491817819754 9.20935302746823e-14 -0.366176880641331 0.0811617780784009 miRNATAP -0.253140145985266 0.00512869243775859 NA NA NA hsa-miR-455-5p UBASH3B -0.270546034117157 0.0581320703577731 -0.366176880641331 0.0811617780784009 miRanda;miRNATAP -0.412372694853776 5.65044072725476e-09 NA NA NA hsa-miR-181b-5p UBB 0.488256489401108 0.00105321129419701 -0.538601985573999 4.76332158900571e-08 miRNAWalker2_validate -0.194003959275969 1.4466728714083e-09 NA NA NA hsa-miR-20a-5p UBC 0.854326758727003 5.04256669663285e-07 -0.0906814920157917 0.264389268870947 miRNATAP -0.123562766810762 4.44028845336169e-08 NA NA NA hsa-miR-181b-5p UBE2B 0.488256489401108 0.00105321129419701 -0.102784203823933 0.199378542308151 MirTarget -0.106595210940937 3.72368496090919e-05 NA NA NA hsa-miR-148a-3p UBE2D1 -0.748702855596996 3.93313343865641e-07 0.0779402641757883 0.369347660871645 MirTarget;miRNATAP -0.171046474154817 6.65939304887809e-10 NA NA NA hsa-miR-192-5p UBE2D1 -0.50188499512787 0.00344713341196035 0.0779402641757883 0.369347660871645 miRNAWalker2_validate -0.106222155367363 1.24584492034061e-05 NA NA NA hsa-miR-132-3p UBE2D3 0.323796239695997 0.00272093067935091 -0.546454726317387 9.53324910574043e-17 miRNATAP -0.140986767552648 3.8594881012371e-06 NA NA NA hsa-miR-181b-5p UBE2D3 0.488256489401108 0.00105321129419701 -0.546454726317387 9.53324910574043e-17 MirTarget;mirMAP -0.120445731017042 3.57692975825359e-08 NA NA NA hsa-miR-21-5p UBE2D3 1.51084295924322 1.54551622173259e-34 -0.546454726317387 9.53324910574043e-17 MirTarget;miRNATAP -0.171121255574583 1.36981728044781e-12 NA NA NA hsa-miR-30c-5p UBE2F -0.432111642767632 0.000159764714931007 -0.0122806894841352 0.868343420804323 MirTarget;miRNATAP -0.105381629276342 0.000744683533325457 NA NA NA hsa-miR-30e-5p UBE2F -0.627815042856657 3.02205690184908e-10 -0.0122806894841352 0.868343420804323 MirTarget;miRNATAP -0.116544164367734 0.00101394063134697 NA NA NA hsa-miR-34a-5p UBE2G1 1.03694231790865 5.74864019540594e-14 -0.508140537363517 1.29132743391725e-11 miRNATAP -0.129194370060115 6.93992265993362e-07 NA NA NA hsa-miR-122-3p UBE2I -1.75369011054591 1.52070648599898e-11 0.437225260766186 9.08527064616308e-09 MirTarget;miRNATAP -0.115171810070314 1.96844494497749e-17 NA NA NA hsa-miR-29c-3p UBE2I -1.4367517608807 1.61767774905781e-21 0.437225260766186 9.08527064616308e-09 mirMAP -0.142341416387826 9.8396582170972e-10 NA NA NA hsa-miR-30e-5p UBE2I -0.627815042856657 3.02205690184908e-10 0.437225260766186 9.08527064616308e-09 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.150039078995558 5.08754178156335e-05 NA NA NA hsa-miR-30b-5p UBE2J1 -0.54056186708617 2.44688760798341e-05 -0.201879198163778 0.00502898980922 MirTarget;miRNATAP -0.110585928755191 4.30231449446542e-05 NA NA NA hsa-miR-214-5p UBE2O -1.91497809567701 3.92955595018147e-12 0.730608942171037 1.13826450024877e-20 MirTarget -0.131430437671011 3.44475208363861e-22 NA NA NA hsa-miR-30c-5p UBE2O -0.432111642767632 0.000159764714931007 0.730608942171037 1.13826450024877e-20 miRNATAP -0.121963591297578 0.000459001563506635 NA NA NA hsa-miR-27b-3p UBE2Q1 -0.823491817819754 9.20935302746823e-14 0.732919157465649 1.09455000536515e-20 miRNATAP -0.159343362586928 5.72262827193909e-06 NA NA NA hsa-miR-455-3p UBE2Q2 -1.3998033821095 5.72010709806871e-17 0.681211675549137 2.94083418901206e-05 MirTarget;PITA;miRNATAP -0.188298844332438 4.03648981645713e-05 NA NA NA hsa-miR-30e-5p UBE2V2 -0.627815042856657 3.02205690184908e-10 0.143036613005897 0.124537482167222 MirTarget -0.163183501048887 0.000259915376049571 NA NA NA hsa-miR-15a-5p UBE2W 0.349521211668244 0.000770735998804736 -0.253775104248129 0.00271466702277899 miRNATAP -0.106140556445063 0.00773586203141691 NA NA NA hsa-miR-20a-5p UBE2W 0.854326758727003 5.04256669663285e-07 -0.253775104248129 0.00271466702277899 miRNATAP -0.14523471171116 6.7036980285473e-10 NA NA NA hsa-miR-181a-5p UBE3C 0.250113435902954 0.0551933249319293 0.0110137435810636 0.905807612215828 MirTarget;miRNATAP -0.135321608743906 9.12965572091032e-05 NA NA NA hsa-miR-181b-5p UBE3C 0.488256489401108 0.00105321129419701 0.0110137435810636 0.905807612215828 MirTarget;miRNATAP -0.10704614742396 0.000381756152235473 NA NA NA hsa-miR-20a-5p UBE3C 0.854326758727003 5.04256669663285e-07 0.0110137435810636 0.905807612215828 MirTarget;miRNATAP -0.131292933667327 4.20100986749961e-07 NA NA NA hsa-miR-30b-5p UBE3C -0.54056186708617 2.44688760798341e-05 0.0110137435810636 0.905807612215828 MirTarget;miRNATAP -0.190716349121824 3.61109396766477e-08 NA NA NA hsa-miR-21-5p UBE4A 1.51084295924322 1.54551622173259e-34 -0.18436367635478 0.00481429470133437 MirTarget;miRNATAP -0.134852775740646 8.06058947743651e-09 NA NA NA hsa-miR-15a-5p UBFD1 0.349521211668244 0.000770735998804736 0.109959650870342 0.181356823499568 MirTarget;miRNATAP -0.11012025246697 0.00426416635714971 NA NA NA hsa-miR-222-3p UBIAD1 1.08574156066353 1.76407192348131e-11 0.0673700687374437 0.430968115372593 miRNAWalker2_validate -0.103105773597962 3.58073244720186e-05 NA NA NA hsa-miR-181a-5p UBL3 0.250113435902954 0.0551933249319293 -0.852818064860432 1.70418663179437e-14 MirTarget;miRNATAP -0.234793363047421 3.17173299151013e-08 NA NA NA hsa-miR-181b-5p UBL3 0.488256489401108 0.00105321129419701 -0.852818064860432 1.70418663179437e-14 MirTarget;mirMAP;miRNATAP -0.214804374974692 5.5599788443542e-09 NA NA NA hsa-miR-29c-3p UBN2 -1.4367517608807 1.61767774905781e-21 0.198392996969249 0.0254762976600423 miRNATAP -0.102949933167903 0.000149015638157676 NA NA NA hsa-miR-20a-5p UBR1 0.854326758727003 5.04256669663285e-07 -0.388222830350535 1.99950729008068e-05 miRNATAP -0.16222861718641 1.75388077295459e-10 NA NA NA hsa-miR-146b-5p UBR2 0.419719546795449 0.0457375823220155 -0.316767830174316 0.00113219683474938 miRanda -0.113958736399944 3.38316353648685e-07 NA NA NA hsa-miR-132-3p UBR3 0.323796239695997 0.00272093067935091 -0.651263693121249 4.19615459779866e-12 miRNATAP -0.22731160214482 1.33336692935895e-07 NA NA NA hsa-miR-15a-5p UBR3 0.349521211668244 0.000770735998804736 -0.651263693121249 4.19615459779866e-12 MirTarget;miRNATAP -0.17038225306744 0.000160177254212002 NA NA NA hsa-miR-21-5p UBR3 1.51084295924322 1.54551622173259e-34 -0.651263693121249 4.19615459779866e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.339040574154486 1.53829829139559e-24 NA NA NA hsa-miR-27b-3p UBR5 -0.823491817819754 9.20935302746823e-14 0.630017235825055 3.7913049521189e-11 MirTarget;miRNATAP -0.140975760866304 0.000750274945723454 NA NA NA hsa-miR-29c-3p UBTD2 -1.4367517608807 1.61767774905781e-21 0.0402573705231211 0.566376944551261 MirTarget;miRNATAP -0.105114656937188 7.19956160064509e-07 NA NA NA hsa-miR-17-3p UBXN10 0.410352776142368 0.00422200500748636 -1.75060710944774 2.42078409774784e-06 mirMAP -0.591140868899291 3.05403095506071e-06 NA NA NA hsa-miR-181b-5p UBXN10 0.488256489401108 0.00105321129419701 -1.75060710944774 2.42078409774784e-06 mirMAP -1.27160835977865 1.41632635035813e-28 NA NA NA hsa-miR-182-5p UBXN10 1.96601340710222 4.39326175603633e-09 -1.75060710944774 2.42078409774784e-06 miRNATAP -0.291984065641992 3.25710389095553e-08 NA NA NA hsa-miR-19b-3p UBXN10 0.601279551368824 0.00016685097085251 -1.75060710944774 2.42078409774784e-06 mirMAP -0.515171571858459 5.39922869324287e-06 NA NA NA hsa-miR-21-5p UBXN10 1.51084295924322 1.54551622173259e-34 -1.75060710944774 2.42078409774784e-06 mirMAP -0.749966978736364 2.92990620999404e-08 NA NA NA hsa-miR-146b-5p UBXN7 0.419719546795449 0.0457375823220155 -0.286357617240146 0.0464067719558195 miRanda;mirMAP -0.101319786986818 0.00233252970709147 NA NA NA hsa-miR-148a-3p UCP3 -0.748702855596996 3.93313343865641e-07 0.738404617511284 2.64780777542046e-07 MirTarget;miRNATAP -0.159569280850398 0.000757623579332943 NA NA NA hsa-miR-20a-5p UEVLD 0.854326758727003 5.04256669663285e-07 0.0899769025084192 0.456741370818853 miRNAWalker2_validate;MirTarget -0.133989226000398 8.03819083058733e-05 NA NA NA hsa-miR-181a-5p UGT3A1 0.250113435902954 0.0551933249319293 -2.70791090631122 2.96529066125781e-06 miRNAWalker2_validate -0.916366615332886 2.8026137263037e-05 NA NA NA hsa-miR-192-5p UGT8 -0.50188499512787 0.00344713341196035 0.668138341470101 0.0469987718329836 miRNAWalker2_validate -0.292812729409313 0.00213398234566189 NA NA NA hsa-miR-215-5p UGT8 -0.981544773246509 3.14452272477156e-05 0.668138341470101 0.0469987718329836 miRNAWalker2_validate -0.285269035967917 3.16731149909607e-05 NA NA NA hsa-miR-455-5p UGT8 -0.270546034117157 0.0581320703577731 0.668138341470101 0.0469987718329836 miRanda -0.252620821388408 0.0287115890588098 NA NA NA hsa-miR-15a-5p UHMK1 0.349521211668244 0.000770735998804736 -0.803204254827771 0.00347508080027661 MirTarget;miRNATAP -0.36088556061017 0.00548195032796662 NA NA NA hsa-miR-17-3p UHMK1 0.410352776142368 0.00422200500748636 -0.803204254827771 0.00347508080027661 MirTarget;miRNATAP -0.358755913349675 0.000121859873865464 NA NA NA hsa-miR-181a-5p UHMK1 0.250113435902954 0.0551933249319293 -0.803204254827771 0.00347508080027661 mirMAP -0.279384437466773 0.00697096920577365 NA NA NA hsa-miR-181b-5p UHMK1 0.488256489401108 0.00105321129419701 -0.803204254827771 0.00347508080027661 mirMAP -0.197196051374925 0.0288087973265019 NA NA NA hsa-miR-19b-3p UHMK1 0.601279551368824 0.00016685097085251 -0.803204254827771 0.00347508080027661 mirMAP;miRNATAP -0.306955412673169 0.000236716650346357 NA NA NA hsa-miR-20a-5p UHMK1 0.854326758727003 5.04256669663285e-07 -0.803204254827771 0.00347508080027661 mirMAP -0.329720592307185 2.18163348512908e-05 NA NA NA hsa-miR-21-5p UHMK1 1.51084295924322 1.54551622173259e-34 -0.803204254827771 0.00347508080027661 mirMAP -0.453633017143944 5.571326226094e-06 NA NA NA hsa-miR-27b-3p UHRF1BP1 -0.823491817819754 9.20935302746823e-14 0.5401627924825 2.70756975187287e-07 miRNATAP -0.108348341530582 0.018063405662785 NA NA NA hsa-miR-455-3p UHRF1BP1 -1.3998033821095 5.72010709806871e-17 0.5401627924825 2.70756975187287e-07 MirTarget -0.128272503286791 1.4809174015909e-05 NA NA NA hsa-miR-192-5p UNC119B -0.50188499512787 0.00344713341196035 1.21392832041535 7.88210718787103e-18 mirMAP -0.156987527395048 0.000155556485932823 NA NA NA hsa-miR-27b-3p UNC119B -0.823491817819754 9.20935302746823e-14 1.21392832041535 7.88210718787103e-18 mirMAP -0.146934003101591 0.0205159803633217 NA NA NA hsa-miR-505-5p UNC119B -0.768282569967001 1.14662846595407e-05 1.21392832041535 7.88210718787103e-18 MirTarget -0.195649439066451 1.12373481882906e-06 NA NA NA hsa-miR-148a-3p UNC13A -0.748702855596996 3.93313343865641e-07 1.88006027872507 4.70766140336401e-08 mirMAP -0.737009176311451 4.54389881051152e-11 NA NA NA hsa-miR-455-5p UNC13A -0.270546034117157 0.0581320703577731 1.88006027872507 4.70766140336401e-08 mirMAP -0.330437969366136 0.00581397472611015 NA NA NA hsa-miR-455-5p UNC5A -0.270546034117157 0.0581320703577731 1.46086450181082 6.53455896088854e-07 PITA;miRanda -0.298073409986158 0.00342240906732601 NA NA NA hsa-miR-192-3p UNC5B -0.6401165114007 0.000266272092403814 0.438096160366062 0.0182898518533137 mirMAP -0.396122256390234 1.53750975066839e-15 NA NA NA hsa-miR-29c-3p UNC5B -1.4367517608807 1.61767774905781e-21 0.438096160366062 0.0182898518533137 mirMAP -0.129053164117363 0.0242979570556807 NA NA NA hsa-miR-455-5p UNC5B -0.270546034117157 0.0581320703577731 0.438096160366062 0.0182898518533137 miRNATAP -0.229224403460595 0.000302505570395368 NA NA NA hsa-miR-505-5p UNC5B -0.768282569967001 1.14662846595407e-05 0.438096160366062 0.0182898518533137 mirMAP -0.166957939087815 0.00111328303471752 NA NA NA hsa-miR-29c-3p UNK -1.4367517608807 1.61767774905781e-21 0.665013703703401 1.18077802069437e-15 miRNATAP -0.215816324766545 1.94381317442539e-17 NA NA NA hsa-miR-27b-3p UNKL -0.823491817819754 9.20935302746823e-14 1.03406637414326 3.3981116867897e-18 miRNATAP -0.192465763822915 0.000296826295135369 NA NA NA hsa-miR-432-5p UPK3B -0.536178819038888 0.0748623258271085 -0.309550942429862 0.157609007728666 MirTarget -0.105903134555252 0.0028514470804702 NA NA NA hsa-miR-192-5p UPP1 -0.50188499512787 0.00344713341196035 -0.042917024406242 0.760665276477023 miRNAWalker2_validate -0.188379087453598 1.81656919109085e-06 NA NA NA hsa-miR-30c-5p UQCRB -0.432111642767632 0.000159764714931007 0.530904901896045 5.90747843765382e-05 MirTarget -0.226967491108861 5.70269374944806e-05 NA NA NA hsa-miR-30e-5p UQCRB -0.627815042856657 3.02205690184908e-10 0.530904901896045 5.90747843765382e-05 MirTarget -0.369400014645982 5.3547259928829e-09 NA NA NA hsa-miR-30c-5p UQCRC1 -0.432111642767632 0.000159764714931007 -0.25877924676415 0.0109004455031638 miRNAWalker2_validate -0.108880814480328 0.0119322066228185 NA NA NA hsa-miR-29c-3p URM1 -1.4367517608807 1.61767774905781e-21 0.377286722665545 4.08493862379565e-05 miRNATAP -0.135061993570542 1.637460946127e-06 NA NA NA hsa-miR-30c-5p URM1 -0.432111642767632 0.000159764714931007 0.377286722665545 4.08493862379565e-05 miRNATAP -0.11900683436701 0.00247724336929851 NA NA NA hsa-miR-222-3p UROD 1.08574156066353 1.76407192348131e-11 -0.19922311099289 0.0464352109324436 miRNAWalker2_validate -0.149895279118668 2.61421429394463e-07 NA NA NA hsa-miR-146b-5p USH2A 0.419719546795449 0.0457375823220155 -2.26734306551942 1.94801387719099e-11 miRanda -0.172458926171405 0.0321410497079729 NA NA NA hsa-miR-15a-5p USP12 0.349521211668244 0.000770735998804736 -1.36092631309918 3.84311050989167e-08 MirTarget;miRNATAP -0.253129569747897 0.0330424798175932 NA NA NA hsa-miR-19b-3p USP12 0.601279551368824 0.00016685097085251 -1.36092631309918 3.84311050989167e-08 MirTarget -0.212314292225847 0.00546929890170568 NA NA NA hsa-miR-21-5p USP15 1.51084295924322 1.54551622173259e-34 -0.501194395838042 8.03199763675317e-16 MirTarget -0.183025140623556 5.04387738895134e-16 NA NA NA hsa-miR-146b-5p USP2 0.419719546795449 0.0457375823220155 -1.07743930780701 1.89309748293681e-06 miRanda -0.137507685916857 0.00957107273121941 NA NA NA hsa-miR-15a-5p USP2 0.349521211668244 0.000770735998804736 -1.07743930780701 1.89309748293681e-06 miRNATAP -0.241490884951617 0.0253005754615208 NA NA NA hsa-miR-432-5p USP2 -0.536178819038888 0.0748623258271085 -1.07743930780701 1.89309748293681e-06 miRNATAP -0.130251337551185 0.000435153506544166 NA NA NA hsa-miR-19b-3p USP32 0.601279551368824 0.00016685097085251 -0.294622923243741 0.00152102677975573 MirTarget -0.102008007160487 0.000290771869043208 NA NA NA hsa-miR-29c-3p USP37 -1.4367517608807 1.61767774905781e-21 0.137344337394476 0.202332777644403 MirTarget;miRNATAP -0.236631854215476 1.82324690137105e-13 NA NA NA hsa-miR-132-3p USP38 0.323796239695997 0.00272093067935091 -1.03326457838017 5.36170633921046e-21 MirTarget -0.23626344287102 5.26440625866639e-06 NA NA NA hsa-miR-192-3p USP46 -0.6401165114007 0.000266272092403814 0.37866037663651 5.0736070332912e-05 mirMAP -0.106810604253525 3.43487199859675e-05 NA NA NA hsa-miR-27b-3p USP46 -0.823491817819754 9.20935302746823e-14 0.37866037663651 5.0736070332912e-05 MirTarget;miRNATAP -0.127230167124479 0.00163105940505326 NA NA NA hsa-miR-30b-5p USP46 -0.54056186708617 2.44688760798341e-05 0.37866037663651 5.0736070332912e-05 mirMAP -0.130410204111492 0.000234867096560691 NA NA NA hsa-miR-181b-5p USP47 0.488256489401108 0.00105321129419701 -0.288927257048455 1.31798435018082e-05 mirMAP -0.104888390679363 1.04415800709323e-06 NA NA NA hsa-miR-21-5p USP47 1.51084295924322 1.54551622173259e-34 -0.288927257048455 1.31798435018082e-05 miRNAWalker2_validate -0.192448823170205 1.94317660562691e-16 NA NA NA hsa-miR-15a-5p USP53 0.349521211668244 0.000770735998804736 -0.885109860248228 1.92362967555312e-09 miRNATAP -0.289913825838165 3.78608471566109e-05 NA NA NA hsa-miR-20a-5p USP53 0.854326758727003 5.04256669663285e-07 -0.885109860248228 1.92362967555312e-09 miRNATAP -0.308556869030845 8.6106929234526e-14 NA NA NA hsa-miR-192-5p USP54 -0.50188499512787 0.00344713341196035 0.621564566787767 0.00139361741036206 miRNAWalker2_validate -0.135230658318964 0.014674125054071 NA NA NA hsa-miR-215-5p USP54 -0.981544773246509 3.14452272477156e-05 0.621564566787767 0.00139361741036206 miRNAWalker2_validate -0.127330501337387 0.00142859874190331 NA NA NA hsa-miR-15a-5p USP9X 0.349521211668244 0.000770735998804736 -0.493726423500345 4.39699853803465e-09 miRNATAP -0.142154239381993 0.000390805725581998 NA NA NA hsa-miR-27b-3p UTP14A -0.823491817819754 9.20935302746823e-14 0.666909942791138 4.39528354807288e-15 miRNAWalker2_validate -0.164568511837303 1.1443127408687e-05 NA NA NA hsa-miR-30c-5p UXT -0.432111642767632 0.000159764714931007 0.0886316215846152 0.335684595901146 miRNAWalker2_validate -0.122662488445927 0.00165005550250536 NA NA NA hsa-miR-19b-3p VAMP3 0.601279551368824 0.00016685097085251 -0.172930065577045 0.0400335982715891 miRNAWalker2_validate;MirTarget -0.135735044904401 6.86798522000962e-08 NA NA NA hsa-miR-148a-3p VANGL1 -0.748702855596996 3.93313343865641e-07 0.205997711038247 0.0305684838094997 mirMAP -0.147424701729889 1.65338009649548e-06 NA NA NA hsa-miR-192-3p VANGL1 -0.6401165114007 0.000266272092403814 0.205997711038247 0.0305684838094997 mirMAP -0.219767721572736 2.87368717362652e-18 NA NA NA hsa-miR-192-5p VANGL1 -0.50188499512787 0.00344713341196035 0.205997711038247 0.0305684838094997 miRNAWalker2_validate -0.228603360029257 8.99222292327043e-19 NA NA NA hsa-miR-181a-5p VAPB 0.250113435902954 0.0551933249319293 0.0546737041423215 0.405598898246678 mirMAP -0.103412337943922 2.06748376179088e-05 NA NA NA hsa-miR-148a-3p VASH1 -0.748702855596996 3.93313343865641e-07 0.376667961316505 0.00837588570446168 mirMAP -0.483186841432644 2.09378989906879e-28 NA NA NA hsa-miR-192-5p VASH1 -0.50188499512787 0.00344713341196035 0.376667961316505 0.00837588570446168 mirMAP -0.342610515460023 1.31882880179242e-18 NA NA NA hsa-miR-192-5p VASH2 -0.50188499512787 0.00344713341196035 1.99409120294188 1.83824386478745e-12 miRNAWalker2_validate -0.167197626011626 0.0431316269095107 NA NA NA hsa-miR-30e-5p VAT1 -0.627815042856657 3.02205690184908e-10 0.562790262628507 4.63985079216808e-06 MirTarget -0.308455930015948 1.91398779823658e-07 NA NA NA hsa-miR-455-3p VAV1 -1.3998033821095 5.72010709806871e-17 -0.805601421816576 0.000238358659912836 miRNATAP -0.257628688670346 2.83762354953326e-05 NA NA NA hsa-miR-455-5p VCAN -0.270546034117157 0.0581320703577731 0.3467634039065 0.320202578720279 miRanda;miRNATAP -0.658824889693079 2.16486973028201e-08 NA NA NA hsa-miR-34a-5p VCL 1.03694231790865 5.74864019540594e-14 -0.258946887530579 0.0173448832237799 miRNAWalker2_validate;miRNATAP -0.142519028474765 0.000127267341803489 NA NA NA hsa-miR-455-5p VCL -0.270546034117157 0.0581320703577731 -0.258946887530579 0.0173448832237799 miRanda -0.154608108935136 2.95888205181105e-05 NA NA NA hsa-miR-181a-5p VCPIP1 0.250113435902954 0.0551933249319293 -0.270295344221587 0.00288329101974505 mirMAP -0.100302246681225 0.00318676874498925 NA NA NA hsa-miR-27b-3p VDR -0.823491817819754 9.20935302746823e-14 0.285990861463055 0.253050689197296 miRNAWalker2_validate;miRTarBase -0.228388027467094 0.0343140214017218 22213330 The expression of VDR mRNA protein and two candidates of VDR microRNAs miR-125b miR-27b were compared in 125OH2D3-responsive MeWo SK-Mel28 and -resistant SK-Mel5 IGR melanoma cell lines and in normal human melanocytes NHM using real time PCR and western blot analysis melanoma hsa-miR-27b-3p VGF -0.823491817819754 9.20935302746823e-14 1.16356565087002 0.000378418082123557 miRNATAP -0.667992401178543 2.03727683507418e-06 NA NA NA hsa-miR-192-5p VGLL3 -0.50188499512787 0.00344713341196035 -0.294230399406651 0.235396784808845 miRNAWalker2_validate -0.41378530704369 2.08640774662643e-09 NA NA NA hsa-miR-19b-3p VGLL3 0.601279551368824 0.00016685097085251 -0.294230399406651 0.235396784808845 mirMAP -0.295904075343081 7.80536699804896e-05 NA NA NA hsa-miR-20a-5p VGLL3 0.854326758727003 5.04256669663285e-07 -0.294230399406651 0.235396784808845 mirMAP -0.392910736979021 1.34602750647278e-08 NA NA NA hsa-miR-17-3p VGLL4 0.410352776142368 0.00422200500748636 0.462391501978053 1.44446047792629e-05 MirTarget -0.138268660853108 0.000142201548030173 NA NA NA hsa-miR-455-3p VGLL4 -1.3998033821095 5.72010709806871e-17 0.462391501978053 1.44446047792629e-05 PITA;miRNATAP -0.103623599006271 0.000563781180475882 NA NA NA hsa-miR-17-3p VIM 0.410352776142368 0.00422200500748636 0.238035988962227 0.0725461526598976 miRNAWalker2_validate;miRNATAP -0.10665167331801 0.0179413566257755 23418359;19771525 In contrast the passenger strand miR-17-3p repressed expression of vimentin an intermediate filament with the ability to modulate metabolism and GalNT7 an enzyme that regulates metabolism of liver toxin galactosamine;The lack of miR-17-3p expression correlated with an increase in vimentin synthesis and tumorigenicity; Stable expression of miR-17-3p in the M12 subline reduced vimentin levels 85% and reverted growth to organized polarized acini in lrECM gels ; liver cancer;prostate cancer hsa-miR-181a-5p VKORC1L1 0.250113435902954 0.0551933249319293 -0.437057501700886 5.88971250408357e-09 mirMAP -0.109384867082696 0.000118663326205077 NA NA NA hsa-miR-30b-5p VKORC1L1 -0.54056186708617 2.44688760798341e-05 -0.437057501700886 5.88971250408357e-09 MirTarget -0.116078475901072 5.16911324682255e-05 NA NA NA hsa-miR-20a-5p VLDLR 0.854326758727003 5.04256669663285e-07 -0.0354447533347528 0.927085642100091 MirTarget;miRNATAP -0.583432446282251 6.96273143743137e-08 NA NA NA hsa-miR-30c-5p VOPP1 -0.432111642767632 0.000159764714931007 0.423540105458752 6.49295901415064e-05 MirTarget;miRNATAP -0.139736556998181 0.00206738166033452 NA NA NA hsa-miR-30e-5p VOPP1 -0.627815042856657 3.02205690184908e-10 0.423540105458752 6.49295901415064e-05 MirTarget -0.352802528500663 2.23143885638822e-12 NA NA NA hsa-miR-21-5p VPS13A 1.51084295924322 1.54551622173259e-34 -0.258302170047732 0.0617206638390793 miRNAWalker2_validate -0.115758656468014 0.0218246546866006 NA NA NA hsa-miR-30e-5p VPS13B -0.627815042856657 3.02205690184908e-10 0.524969569350586 4.08830378695552e-07 miRNAWalker2_validate -0.105090396481035 0.0383626611263215 NA NA NA hsa-miR-20a-5p VPS13C 0.854326758727003 5.04256669663285e-07 -0.351124153310034 0.00206558617446539 MirTarget -0.188265323528369 3.30757552196579e-09 NA NA NA hsa-miR-455-5p VPS13C -0.270546034117157 0.0581320703577731 -0.351124153310034 0.00206558617446539 MirTarget;PITA;miRanda -0.220902232522652 9.69866348328215e-09 NA NA NA hsa-miR-29c-3p VPS25 -1.4367517608807 1.61767774905781e-21 0.334652043393858 5.05499552485946e-05 miRNATAP -0.127182052109355 4.62028617464338e-07 NA NA NA hsa-miR-17-3p VPS36 0.410352776142368 0.00422200500748636 -0.567458160061146 1.90597492149183e-08 miRNATAP -0.100839967799676 0.00375417350401107 NA NA NA hsa-miR-181a-5p VPS36 0.250113435902954 0.0551933249319293 -0.567458160061146 1.90597492149183e-08 mirMAP -0.142333308003483 0.000201442254840339 NA NA NA hsa-miR-181b-5p VPS36 0.488256489401108 0.00105321129419701 -0.567458160061146 1.90597492149183e-08 mirMAP -0.16210964164094 9.75256633910275e-07 NA NA NA hsa-miR-21-5p VPS36 1.51084295924322 1.54551622173259e-34 -0.567458160061146 1.90597492149183e-08 miRNAWalker2_validate -0.272758977873715 5.74486244863826e-14 NA NA NA hsa-miR-194-5p VPS37B -0.292530160992458 0.0996141384876663 -0.432660637098686 0.000132347664632214 mirMAP -0.208916312585699 7.73430163568641e-12 NA NA NA hsa-miR-29c-3p VPS37C -1.4367517608807 1.61767774905781e-21 0.523558943404517 1.59955591546831e-13 MirTarget -0.140824999158193 1.34399626250155e-10 NA NA NA hsa-miR-19b-3p VPS41 0.601279551368824 0.00016685097085251 0.0565720571540389 0.508094954768997 mirMAP -0.13287670921126 1.91121707151771e-07 NA NA NA hsa-miR-99a-5p VPS45 -1.51481656384839 3.93230057259529e-14 1.12270489816642 1.6416505013997e-44 miRNAWalker2_validate -0.127715298723187 6.32311023730463e-10 NA NA NA hsa-miR-15a-5p VPS4A 0.349521211668244 0.000770735998804736 -0.0577480350836463 0.447251296182323 MirTarget -0.111807355796318 0.00163063203044394 NA NA NA hsa-miR-19b-3p VPS4B 0.601279551368824 0.00016685097085251 -0.449061737304732 2.12825252432465e-09 miRNAWalker2_validate;MirTarget;miRNATAP -0.144415564236473 1.81597669930391e-10 NA NA NA hsa-miR-181a-5p VPS52 0.250113435902954 0.0551933249319293 0.349883435414734 2.09921089731539e-06 mirMAP -0.121637012170799 1.08057452491307e-05 NA NA NA hsa-miR-181b-5p VPS52 0.488256489401108 0.00105321129419701 0.349883435414734 2.09921089731539e-06 mirMAP -0.118562035576257 7.58482369308195e-07 NA NA NA hsa-miR-148a-3p VSIG1 -0.748702855596996 3.93313343865641e-07 1.90287436342957 8.4567956200768e-06 MirTarget -1.08529741673112 1.88037146106369e-15 NA NA NA hsa-miR-148a-3p VSIG10 -0.748702855596996 3.93313343865641e-07 0.873850880690775 6.42061314499011e-13 MirTarget -0.233949805248073 5.70720661265099e-09 NA NA NA hsa-miR-455-5p VSIG4 -0.270546034117157 0.0581320703577731 -2.36538186284695 2.18871150997747e-21 miRanda -0.438888605970737 7.9207177630846e-07 NA NA NA hsa-miR-181b-5p VSNL1 0.488256489401108 0.00105321129419701 -0.874873254541304 0.0199688194916894 miRNAWalker2_validate;miRTarBase -0.542565101990497 8.83517963771935e-06 NA NA NA hsa-miR-21-5p VSNL1 1.51084295924322 1.54551622173259e-34 -0.874873254541304 0.0199688194916894 MirTarget -0.326524166662513 0.0176627942750373 NA NA NA hsa-miR-15a-5p VTCN1 0.349521211668244 0.000770735998804736 -3.78440062258067 2.67000096346844e-15 miRNATAP -1.13689058393093 8.98605950040529e-07 NA NA NA hsa-miR-29c-3p WASF1 -1.4367517608807 1.61767774905781e-21 0.439540363305626 0.00258561023132441 MirTarget -0.372052024413204 8.32529595165071e-18 NA NA NA hsa-miR-34a-5p WASF1 1.03694231790865 5.74864019540594e-14 0.439540363305626 0.00258561023132441 MirTarget;miRNATAP -0.177366062622499 0.000398732266778735 NA NA NA hsa-miR-455-3p WASF2 -1.3998033821095 5.72010709806871e-17 0.714055052870812 1.10967798883342e-14 mirMAP -0.170832143013363 6.75979063283062e-11 NA NA NA hsa-miR-15a-5p WASL 0.349521211668244 0.000770735998804736 -0.151210138994514 0.0497433874528767 MirTarget;miRNATAP -0.117641509586538 0.00110360242778068 NA NA NA hsa-miR-181a-5p WASL 0.250113435902954 0.0551933249319293 -0.151210138994514 0.0497433874528767 MirTarget;miRNATAP -0.132883871468848 3.21128473852748e-06 NA NA NA hsa-miR-181b-5p WASL 0.488256489401108 0.00105321129419701 -0.151210138994514 0.0497433874528767 MirTarget;miRNATAP -0.116039090843406 2.93502543332777e-06 NA NA NA hsa-miR-146b-5p WDFY3 0.419719546795449 0.0457375823220155 -0.56665445395217 1.30950023006267e-05 miRanda -0.112254589538848 0.000208875386675096 NA NA NA hsa-miR-19b-3p WDFY3 0.601279551368824 0.00016685097085251 -0.56665445395217 1.30950023006267e-05 MirTarget;miRNATAP -0.20307034883908 2.48986356699701e-07 NA NA NA hsa-miR-20a-5p WDFY3 0.854326758727003 5.04256669663285e-07 -0.56665445395217 1.30950023006267e-05 MirTarget;miRNATAP -0.233851435646906 1.3191917612642e-10 NA NA NA hsa-miR-455-5p WDFY3 -0.270546034117157 0.0581320703577731 -0.56665445395217 1.30950023006267e-05 miRNATAP -0.248072620305688 2.06427469401294e-08 NA NA NA hsa-miR-34a-5p WDFY4 1.03694231790865 5.74864019540594e-14 -0.772515998360695 0.00122387279638213 mirMAP -0.310850017454915 0.000153293881916665 NA NA NA hsa-miR-455-3p WDFY4 -1.3998033821095 5.72010709806871e-17 -0.772515998360695 0.00122387279638213 mirMAP -0.279770230792177 2.9372672538894e-05 NA NA NA hsa-miR-455-5p WDFY4 -0.270546034117157 0.0581320703577731 -0.772515998360695 0.00122387279638213 mirMAP -0.251805252110165 0.00216096064602943 NA NA NA hsa-miR-146b-5p WDR31 0.419719546795449 0.0457375823220155 -0.785530686652774 0.0010331138522558 miRanda -0.124088887690319 0.0262945570146548 NA NA NA hsa-miR-455-5p WDR35 -0.270546034117157 0.0581320703577731 0.109655450770993 0.367950587479403 miRanda -0.116338596216324 0.005133285531652 NA NA NA hsa-miR-27b-3p WDR37 -0.823491817819754 9.20935302746823e-14 0.118154887215613 0.147861987325504 miRNATAP -0.104092327240391 0.00290740843368926 NA NA NA hsa-miR-19b-3p WDR44 0.601279551368824 0.00016685097085251 -0.544362894748902 4.16682403236022e-05 MirTarget;miRNATAP -0.222004220642526 3.03073302600256e-08 NA NA NA hsa-miR-192-5p WDR47 -0.50188499512787 0.00344713341196035 -0.0410364454978813 0.699801723145165 miRNAWalker2_validate -0.133275888079536 7.85584446595926e-06 NA NA NA hsa-miR-455-5p WDR47 -0.270546034117157 0.0581320703577731 -0.0410364454978813 0.699801723145165 miRanda -0.186559742426801 1.97982848057783e-07 NA NA NA hsa-miR-181b-5p WDR7 0.488256489401108 0.00105321129419701 -0.721226430814737 5.8107002873624e-15 mirMAP -0.215508760562926 1.17439975895588e-12 NA NA NA hsa-miR-21-5p WDR7 1.51084295924322 1.54551622173259e-34 -0.721226430814737 5.8107002873624e-15 miRNAWalker2_validate -0.337348716012021 8.71348629464671e-25 NA NA NA hsa-miR-15a-5p WISP1 0.349521211668244 0.000770735998804736 -0.954052774068313 0.000455131867008614 MirTarget -0.344850242636692 0.00750433258915291 NA NA NA hsa-miR-455-3p WISP2 -1.3998033821095 5.72010709806871e-17 -2.42297378958593 4.07723387739639e-09 miRNATAP -0.392973467382022 0.000834061180907858 NA NA NA hsa-miR-148a-3p WNK2 -0.748702855596996 3.93313343865641e-07 -1.89518323977929 0.000316140316980393 mirMAP -1.46012560842666 1.47894869196561e-18 NA NA NA hsa-miR-505-5p WNK2 -0.768282569967001 1.14662846595407e-05 -1.89518323977929 0.000316140316980393 mirMAP -0.439632933303499 0.00261244898793188 NA NA NA hsa-miR-146b-5p WNK3 0.419719546795449 0.0457375823220155 -0.836532944570787 0.00785592148273515 miRanda -0.163424915121321 0.025728368851299 NA NA NA hsa-miR-181a-5p WNK3 0.250113435902954 0.0551933249319293 -0.836532944570787 0.00785592148273515 miRNATAP -0.511997877403235 1.34755901390419e-05 NA NA NA hsa-miR-181b-5p WNK3 0.488256489401108 0.00105321129419701 -0.836532944570787 0.00785592148273515 miRNATAP -0.549486690120314 6.57334699929943e-08 NA NA NA hsa-miR-21-5p WNK3 1.51084295924322 1.54551622173259e-34 -0.836532944570787 0.00785592148273515 miRNAWalker2_validate -0.876883933429564 3.74623998197249e-15 NA NA NA hsa-miR-221-3p WNK3 1.12244756358612 3.48370308238012e-13 -0.836532944570787 0.00785592148273515 miRNATAP -0.359498038872179 0.000199806844922679 NA NA NA hsa-miR-222-3p WNK3 1.08574156066353 1.76407192348131e-11 -0.836532944570787 0.00785592148273515 miRNATAP -0.430718909338276 3.07021843650434e-06 NA NA NA hsa-miR-30b-5p WNK3 -0.54056186708617 2.44688760798341e-05 -0.836532944570787 0.00785592148273515 miRNATAP -0.234994747860448 0.0499871954767786 NA NA NA hsa-miR-409-3p WNK3 -0.499649792570937 0.0526751181520117 -0.836532944570787 0.00785592148273515 mirMAP -0.151146308655115 0.0112003699179312 NA NA NA hsa-miR-146a-5p WNT3 -0.742958238440575 0.000765983177482633 -0.0427691985857284 0.782956133291661 MirTarget -0.113145320629351 0.000853907137316349 NA NA NA hsa-miR-27b-3p WNT3A -0.823491817819754 9.20935302746823e-14 1.98708616870099 1.63071643507271e-06 miRNATAP -0.548421477531898 0.00239496180403094 NA NA NA hsa-miR-34a-5p WNT7B 1.03694231790865 5.74864019540594e-14 -2.49986156980565 3.55477150766295e-09 mirMAP -0.871435014929295 2.29802092991709e-09 NA NA NA hsa-miR-27b-3p WSB1 -0.823491817819754 9.20935302746823e-14 0.0151743647458531 0.894086000237508 MirTarget -0.121375020342005 0.0131677403362887 NA NA NA hsa-miR-29c-3p WSB2 -1.4367517608807 1.61767774905781e-21 0.424425260254082 1.45688999229631e-07 miRNAWalker2_validate -0.122470649667124 8.2017006937421e-07 NA NA NA hsa-miR-15a-5p WTIP 0.349521211668244 0.000770735998804736 -0.0832426426141142 0.690200115614904 mirMAP -0.29463639461455 0.00267774255027973 NA NA NA hsa-miR-192-3p WTIP -0.6401165114007 0.000266272092403814 -0.0832426426141142 0.690200115614904 mirMAP -0.518330466923842 3.62497039745491e-21 NA NA NA hsa-miR-194-5p WTIP -0.292530160992458 0.0996141384876663 -0.0832426426141142 0.690200115614904 mirMAP -0.518590841195274 1.9596398848406e-21 NA NA NA hsa-miR-224-3p WTIP 1.40770116795301 1.31426607144612e-08 -0.0832426426141142 0.690200115614904 mirMAP -0.136303154673275 0.000818990852537711 NA NA NA hsa-miR-34a-5p WTIP 1.03694231790865 5.74864019540594e-14 -0.0832426426141142 0.690200115614904 mirMAP -0.201436728429057 0.00489904366312482 NA NA NA hsa-miR-455-3p WTIP -1.3998033821095 5.72010709806871e-17 -0.0832426426141142 0.690200115614904 mirMAP -0.175801256772203 0.00263244869579529 NA NA NA hsa-miR-15a-5p WWC1 0.349521211668244 0.000770735998804736 -0.0161026660407861 0.921171669363241 MirTarget;miRNATAP -0.375295222921777 7.14197465337921e-07 NA NA NA hsa-miR-20a-5p WWC1 0.854326758727003 5.04256669663285e-07 -0.0161026660407861 0.921171669363241 mirMAP -0.128497978139045 0.00519897748400934 NA NA NA hsa-miR-20b-5p WWC1 0.457668023910379 0.0285865211936156 -0.0161026660407861 0.921171669363241 mirMAP -0.109817069384545 0.00365195437422561 NA NA NA hsa-miR-132-3p WWC2 0.323796239695997 0.00272093067935091 -0.895367958967769 3.36316136449853e-11 mirMAP -0.221503352611201 0.000392793493605304 NA NA NA hsa-miR-181a-5p WWC2 0.250113435902954 0.0551933249319293 -0.895367958967769 3.36316136449853e-11 mirMAP -0.117617510239626 0.0235544938079523 NA NA NA hsa-miR-181b-5p WWC2 0.488256489401108 0.00105321129419701 -0.895367958967769 3.36316136449853e-11 mirMAP -0.117743355113198 0.0090952729115219 NA NA NA hsa-miR-21-5p WWC2 1.51084295924322 1.54551622173259e-34 -0.895367958967769 3.36316136449853e-11 miRNAWalker2_validate -0.397341260935548 3.38337582715096e-16 NA NA NA hsa-miR-192-5p WWC3 -0.50188499512787 0.00344713341196035 0.418904533622248 0.000277343107042062 miRNAWalker2_validate -0.253775313448794 1.24286775769514e-15 NA NA NA hsa-miR-215-5p WWC3 -0.981544773246509 3.14452272477156e-05 0.418904533622248 0.000277343107042062 miRNAWalker2_validate -0.121751903982971 2.00785255039388e-07 NA NA NA hsa-miR-455-5p WWC3 -0.270546034117157 0.0581320703577731 0.418904533622248 0.000277343107042062 miRanda -0.211680329818006 6.1959097110243e-08 NA NA NA hsa-miR-19b-3p WWP1 0.601279551368824 0.00016685097085251 -0.284557742100827 0.0121583242148448 miRNATAP -0.117286878379094 0.000646986827186651 NA NA NA hsa-miR-30c-5p WWP1 -0.432111642767632 0.000159764714931007 -0.284557742100827 0.0121583242148448 MirTarget -0.100306831053726 0.0383742261269566 NA NA NA hsa-miR-17-3p WWTR1 0.410352776142368 0.00422200500748636 -0.430971920019913 0.016793119742098 MirTarget -0.374639628361785 4.93205986633625e-10 NA NA NA hsa-miR-455-5p XAF1 -0.270546034117157 0.0581320703577731 -0.708470222273448 0.000141494577416903 miRanda -0.191709849229909 0.00278801648188576 NA NA NA hsa-miR-455-3p XCL2 -1.3998033821095 5.72010709806871e-17 -0.715465127447571 0.00569128370583897 MirTarget -0.225557417174734 0.00192937587274019 NA NA NA hsa-miR-181a-5p XIAP 0.250113435902954 0.0551933249319293 -0.15308594423064 0.0753030128680062 miRNAWalker2_validate;miRTarBase;mirMAP -0.155528144427296 1.04965693208633e-06 NA NA NA hsa-miR-181b-5p XIAP 0.488256489401108 0.00105321129419701 -0.15308594423064 0.0753030128680062 miRNAWalker2_validate;miRTarBase;mirMAP -0.110373062475686 7.3789440913243e-05 NA NA NA hsa-miR-19b-3p XIAP 0.601279551368824 0.00016685097085251 -0.15308594423064 0.0753030128680062 mirMAP -0.102901223661673 7.13974360361232e-05 NA NA NA hsa-miR-20a-5p XIAP 0.854326758727003 5.04256669663285e-07 -0.15308594423064 0.0753030128680062 miRNATAP -0.159439128688726 1.8964942127771e-11 NA NA NA hsa-miR-181b-5p XKR9 0.488256489401108 0.00105321129419701 -0.811781509743297 0.0361203049863371 mirMAP -0.52490902119526 3.05513325742417e-05 NA NA NA hsa-miR-21-5p XPNPEP3 1.51084295924322 1.54551622173259e-34 -0.229940045643978 0.00504351402350879 mirMAP -0.124609379810193 2.69785828752746e-05 NA NA NA hsa-miR-27b-3p XPO1 -0.823491817819754 9.20935302746823e-14 0.457663973329897 3.78607050139453e-13 miRNATAP -0.105363493354515 0.000135972684704308 NA NA NA hsa-miR-29c-3p XPO5 -1.4367517608807 1.61767774905781e-21 0.924250934584309 5.58683264436527e-22 miRNATAP -0.320027278511149 2.83137909027398e-28 NA NA NA hsa-miR-30b-5p XPR1 -0.54056186708617 2.44688760798341e-05 0.544137944622799 1.91103515215534e-07 MirTarget;mirMAP -0.13458621115273 0.000762528897517718 NA NA NA hsa-miR-455-5p XRCC4 -0.270546034117157 0.0581320703577731 0.588804068054044 9.08376125031661e-08 MirTarget;miRanda;miRNATAP -0.145060661095756 0.000138175907364143 NA NA NA hsa-miR-20a-5p XRN1 0.854326758727003 5.04256669663285e-07 -0.583371990207323 2.03152104936498e-09 MirTarget;miRNATAP -0.103377808005773 0.000213791480229131 NA NA NA hsa-miR-34a-5p XRN1 1.03694231790865 5.74864019540594e-14 -0.583371990207323 2.03152104936498e-09 miRNAWalker2_validate -0.151127129004247 7.42929957573679e-06 25797256 Repression of miR-34a a known AR-targeting miRNA contributes AR expression by XRN1 prostate cancer hsa-miR-148a-3p XYLT1 -0.748702855596996 3.93313343865641e-07 -0.33071246838403 0.0992663538586554 mirMAP -0.574785330152198 4.45980178241601e-20 NA NA NA hsa-miR-15a-5p XYLT1 0.349521211668244 0.000770735998804736 -0.33071246838403 0.0992663538586554 mirMAP -0.332765806956021 0.000412127132225986 NA NA NA hsa-miR-19b-3p XYLT1 0.601279551368824 0.00016685097085251 -0.33071246838403 0.0992663538586554 mirMAP -0.204652664426322 0.000760830428190103 NA NA NA hsa-miR-20a-5p XYLT1 0.854326758727003 5.04256669663285e-07 -0.33071246838403 0.0992663538586554 mirMAP -0.267618441834841 2.01222160008557e-06 NA NA NA hsa-miR-30e-5p XYLT1 -0.627815042856657 3.02205690184908e-10 -0.33071246838403 0.0992663538586554 mirMAP -0.194801766334892 0.0449383761803398 NA NA NA hsa-miR-34a-5p XYLT1 1.03694231790865 5.74864019540594e-14 -0.33071246838403 0.0992663538586554 MirTarget;miRNATAP -0.189669249037874 0.00590087483834711 NA NA NA hsa-miR-455-3p XYLT1 -1.3998033821095 5.72010709806871e-17 -0.33071246838403 0.0992663538586554 mirMAP -0.269697603370512 1.31511382372511e-06 NA NA NA hsa-miR-181a-5p YIPF4 0.250113435902954 0.0551933249319293 -0.452912538074102 8.76433251729972e-10 mirMAP -0.121729685833637 1.3248098715454e-05 NA NA NA hsa-miR-181b-5p YIPF4 0.488256489401108 0.00105321129419701 -0.452912538074102 8.76433251729972e-10 mirMAP -0.115258425929666 2.01845212733732e-06 NA NA NA hsa-miR-15a-5p YIPF6 0.349521211668244 0.000770735998804736 -0.130504002208799 0.166772554218636 MirTarget;miRNATAP -0.16757437450381 0.000144982979494685 NA NA NA hsa-miR-181a-5p YIPF6 0.250113435902954 0.0551933249319293 -0.130504002208799 0.166772554218636 mirMAP -0.208254214389484 1.92634936590221e-09 NA NA NA hsa-miR-181b-5p YIPF6 0.488256489401108 0.00105321129419701 -0.130504002208799 0.166772554218636 mirMAP -0.16287487763089 7.64833777625043e-08 NA NA NA hsa-miR-30b-5p YIPF6 -0.54056186708617 2.44688760798341e-05 -0.130504002208799 0.166772554218636 MirTarget -0.122455803025024 0.000569785395243362 NA NA NA hsa-miR-455-5p YIPF6 -0.270546034117157 0.0581320703577731 -0.130504002208799 0.166772554218636 miRNATAP -0.110744175098113 0.000561661343038083 NA NA NA hsa-miR-192-5p YKT6 -0.50188499512787 0.00344713341196035 0.744521665004512 6.43148276458938e-19 mirMAP -0.184317352823526 1.58004815463837e-14 NA NA NA hsa-miR-20a-5p YPEL1 0.854326758727003 5.04256669663285e-07 -0.0280512828396375 0.84677585658497 MirTarget -0.118192189384931 0.0039389305228129 NA NA NA hsa-miR-146b-5p YPEL2 0.419719546795449 0.0457375823220155 -1.00622202873194 2.21196225043249e-15 miRanda -0.130152462332734 1.67294431044594e-05 NA NA NA hsa-miR-21-5p YPEL2 1.51084295924322 1.54551622173259e-34 -1.00622202873194 2.21196225043249e-15 mirMAP -0.2748162339351 5.62347618311405e-09 NA NA NA hsa-miR-34a-5p YTHDC1 1.03694231790865 5.74864019540594e-14 -0.284095264117558 3.25260344539654e-07 miRNATAP -0.106361290466504 1.76364361950763e-08 NA NA NA hsa-miR-181a-5p YTHDC2 0.250113435902954 0.0551933249319293 -0.261868884098192 0.00522420617690561 MirTarget -0.119489363949442 0.000659646862554132 NA NA NA hsa-miR-181b-5p YTHDC2 0.488256489401108 0.00105321129419701 -0.261868884098192 0.00522420617690561 MirTarget -0.116338635435983 0.000134061154737012 NA NA NA hsa-miR-148a-3p YWHAB -0.748702855596996 3.93313343865641e-07 0.173432047741129 0.000884243127746855 MirTarget;miRNATAP -0.132820922282045 4.13292521804208e-16 NA NA NA hsa-miR-192-3p YWHAH -0.6401165114007 0.000266272092403814 0.381424797266773 9.9564983661589e-07 MirTarget -0.123473061996178 7.45881423647248e-09 NA NA NA hsa-miR-30c-5p YWHAZ -0.432111642767632 0.000159764714931007 0.521348507448096 2.46588555709085e-06 MirTarget;miRNATAP -0.217149970191143 4.21662119138978e-06 24519092 Involvement of miR 30c in resistance to doxorubicin by regulating YWHAZ in breast cancer cells; Together our findings provided evidence that miR-30c was one of the important miRNAs in doxorubicin resistance by regulating YWHAZ in the breast cancer cell line MCF-7/ADR drug resistance breast cancer hsa-miR-30e-5p YWHAZ -0.627815042856657 3.02205690184908e-10 0.521348507448096 2.46588555709085e-06 MirTarget;miRNATAP -0.512830738492514 1.08747499679871e-23 NA NA NA hsa-miR-451a YWHAZ -2.1025161666445 6.82555767537341e-17 0.521348507448096 2.46588555709085e-06 MirTarget;miRNATAP -0.125160799099819 8.46499537092129e-10 26885274 miR 451 regulates FoxO3 nuclear accumulation through Ywhaz in human colorectal cancer; In this study expressions of miR-451 and Ywhaz in CRC tissues and adjacent normal tissues were detected by quantitative real-time PCR qRT-PCR and immunohistochemistry respectively; Ywhaz-3'UTR luciferase reporter assay confirmed Ywhaz as a direct target gene of miR-451; miR-451 may inhibit the colon cancer growth in vitro and in vivo likely through directly targeting Ywhaz and indirectly regulating the nuclear accumulation of FoxO3 colorectal cancer hsa-miR-455-3p YWHAZ -1.3998033821095 5.72010709806871e-17 0.521348507448096 2.46588555709085e-06 miRNAWalker2_validate -0.163253715474292 1.350262159478e-07 NA NA NA hsa-miR-505-5p YWHAZ -0.768282569967001 1.14662846595407e-05 0.521348507448096 2.46588555709085e-06 MirTarget;miRNATAP -0.138532797418727 5.93157816903527e-06 NA NA NA hsa-miR-30b-5p YY2 -0.54056186708617 2.44688760798341e-05 -0.688571686843905 0.00363321004347273 MirTarget -0.314262235771043 0.000465492023446714 NA NA NA hsa-miR-20a-5p ZADH2 0.854326758727003 5.04256669663285e-07 -1.17032856012737 5.54900778507354e-29 MirTarget -0.124416330397247 8.4080772800613e-05 NA NA NA hsa-miR-21-5p ZADH2 1.51084295924322 1.54551622173259e-34 -1.17032856012737 5.54900778507354e-29 miRNAWalker2_validate;mirMAP -0.449898962343669 1.55114134739767e-32 NA NA NA hsa-miR-221-3p ZADH2 1.12244756358612 3.48370308238012e-13 -1.17032856012737 5.54900778507354e-29 MirTarget -0.204256955835515 1.70495598867942e-09 NA NA NA hsa-miR-222-3p ZADH2 1.08574156066353 1.76407192348131e-11 -1.17032856012737 5.54900778507354e-29 MirTarget -0.175520156319588 7.83868490783052e-08 NA NA NA hsa-miR-146a-5p ZBED3 -0.742958238440575 0.000765983177482633 0.219745258993966 0.213330166431833 mirMAP -0.132820468333048 0.000583508096996526 NA NA NA hsa-miR-146b-5p ZBED3 0.419719546795449 0.0457375823220155 0.219745258993966 0.213330166431833 mirMAP -0.104804794433812 0.0104067918610426 NA NA NA hsa-miR-181a-5p ZBED3 0.250113435902954 0.0551933249319293 0.219745258993966 0.213330166431833 mirMAP -0.142780552605171 0.0312792966028402 NA NA NA hsa-miR-181b-5p ZBED3 0.488256489401108 0.00105321129419701 0.219745258993966 0.213330166431833 mirMAP -0.126427968960632 0.0283549982223334 NA NA NA hsa-miR-148a-3p ZBED4 -0.748702855596996 3.93313343865641e-07 0.53235542847144 2.61984249684361e-08 miRNATAP -0.143825624792037 4.72475716954346e-06 NA NA NA hsa-miR-132-3p ZBTB10 0.323796239695997 0.00272093067935091 -1.01864761075705 2.61637300384558e-12 mirMAP -0.165774847371845 0.0145439189663284 NA NA NA hsa-miR-19b-3p ZBTB10 0.601279551368824 0.00016685097085251 -1.01864761075705 2.61637300384558e-12 MirTarget;miRNATAP -0.128863069491514 0.00452407158537307 NA NA NA hsa-miR-181b-5p ZBTB20 0.488256489401108 0.00105321129419701 -0.721517199741877 6.05331504375829e-06 miRNAWalker2_validate -0.199630583842404 0.0001371165199711 NA NA NA hsa-miR-21-5p ZBTB20 1.51084295924322 1.54551622173259e-34 -0.721517199741877 6.05331504375829e-06 miRNAWalker2_validate -0.308921012280672 1.02102349879985e-07 NA NA NA hsa-miR-181a-5p ZBTB33 0.250113435902954 0.0551933249319293 0.176119332344838 0.119623028344143 mirMAP -0.107406099506631 0.0112908697754009 NA NA NA hsa-miR-29c-3p ZBTB34 -1.4367517608807 1.61767774905781e-21 0.377013703257521 0.000168925671855812 MirTarget;miRNATAP -0.244785207577524 2.64234403805196e-16 NA NA NA hsa-miR-21-5p ZBTB38 1.51084295924322 1.54551622173259e-34 -0.322190916866726 0.022072727436213 miRNAWalker2_validate -0.135442175892406 0.00840003737850539 NA NA NA hsa-miR-30b-5p ZBTB38 -0.54056186708617 2.44688760798341e-05 -0.322190916866726 0.022072727436213 miRNAWalker2_validate;mirMAP -0.198416350396865 0.000189655697013732 NA NA NA hsa-miR-30b-5p ZBTB39 -0.54056186708617 2.44688760798341e-05 0.298869678409894 0.00533252508909905 MirTarget -0.115127439249092 0.00463729683564399 NA NA NA hsa-miR-192-5p ZBTB4 -0.50188499512787 0.00344713341196035 -0.124027749172316 0.179982248480507 miRNATAP -0.272262427336687 5.98537345709053e-29 NA NA NA hsa-miR-19b-3p ZBTB4 0.601279551368824 0.00016685097085251 -0.124027749172316 0.179982248480507 miRNAWalker2_validate;MirTarget;miRNATAP -0.17419230921179 2.17709216386897e-10 NA NA NA hsa-miR-20a-5p ZBTB4 0.854326758727003 5.04256669663285e-07 -0.124027749172316 0.179982248480507 MirTarget;miRNATAP -0.188729695695599 1.00298776596306e-13 NA NA NA hsa-miR-29c-3p ZBTB40 -1.4367517608807 1.61767774905781e-21 1.05248854418575 1.34458961008934e-27 miRNATAP -0.227113611405085 1.90535603613798e-13 NA NA NA hsa-miR-30e-5p ZBTB40 -0.627815042856657 3.02205690184908e-10 1.05248854418575 1.34458961008934e-27 mirMAP -0.109526534942994 0.0282689639962591 NA NA NA hsa-miR-455-3p ZBTB40 -1.3998033821095 5.72010709806871e-17 1.05248854418575 1.34458961008934e-27 MirTarget -0.164998542563593 7.03951515516286e-09 NA NA NA hsa-miR-27b-3p ZBTB41 -0.823491817819754 9.20935302746823e-14 0.681392504641194 1.18278307943778e-07 MirTarget -0.173093239984597 0.00203901987506602 NA NA NA hsa-miR-15a-5p ZBTB44 0.349521211668244 0.000770735998804736 -0.241565705391832 0.00708087898285513 MirTarget;miRNATAP -0.166132526794439 7.63627774678942e-05 NA NA NA hsa-miR-148a-3p ZBTB46 -0.748702855596996 3.93313343865641e-07 0.368572640104064 0.00472649256163026 mirMAP -0.261027892187004 4.71083373690452e-10 NA NA NA hsa-miR-192-5p ZBTB46 -0.50188499512787 0.00344713341196035 0.368572640104064 0.00472649256163026 mirMAP -0.153748296687761 2.97987507117192e-05 NA NA NA hsa-miR-132-3p ZBTB5 0.323796239695997 0.00272093067935091 0.0873380853541432 0.310410192391979 mirMAP -0.125459672101752 0.00121041331761833 NA NA NA hsa-miR-29c-3p ZBTB5 -1.4367517608807 1.61767774905781e-21 0.0873380853541432 0.310410192391979 MirTarget;miRNATAP -0.167481602430851 8.7865110197912e-11 NA NA NA hsa-miR-34a-5p ZBTB5 1.03694231790865 5.74864019540594e-14 0.0873380853541432 0.310410192391979 MirTarget -0.130598229602144 7.70659609680475e-06 NA NA NA hsa-miR-20a-5p ZBTB7A 0.854326758727003 5.04256669663285e-07 -0.16342620037259 0.0332447232508199 MirTarget;miRNATAP -0.158307583516785 5.0814483994578e-14 NA NA NA hsa-miR-20b-5p ZBTB7A 0.457668023910379 0.0285865211936156 -0.16342620037259 0.0332447232508199 MirTarget;miRNATAP -0.11460790153602 4.69395623226042e-11 NA NA NA hsa-miR-15a-5p ZC3H12C 0.349521211668244 0.000770735998804736 -0.901395268828268 9.92571024572182e-11 MirTarget -0.216459894675743 0.00123355072498729 NA NA NA hsa-miR-20a-5p ZC3H12C 0.854326758727003 5.04256669663285e-07 -0.901395268828268 9.92571024572182e-11 MirTarget;miRNATAP -0.237873217891635 2.04220503571936e-09 NA NA NA hsa-miR-221-3p ZC3H13 1.12244756358612 3.48370308238012e-13 -0.683664609759774 3.46943555156077e-07 MirTarget -0.141864841939699 0.000660440736530989 NA NA NA hsa-miR-222-3p ZC3H13 1.08574156066353 1.76407192348131e-11 -0.683664609759774 3.46943555156077e-07 MirTarget -0.134261255929837 0.000784335512510069 NA NA NA hsa-miR-181a-5p ZC3H6 0.250113435902954 0.0551933249319293 -0.213328047752035 0.0574717114596243 miRNATAP -0.12122647469184 0.00393952822538377 NA NA NA hsa-miR-181b-5p ZC3H6 0.488256489401108 0.00105321129419701 -0.213328047752035 0.0574717114596243 miRNATAP -0.147413759142574 5.12832667274402e-05 NA NA NA hsa-miR-19b-3p ZC3H6 0.601279551368824 0.00016685097085251 -0.213328047752035 0.0574717114596243 mirMAP -0.158053032652951 2.84533907373442e-06 NA NA NA hsa-miR-30c-5p ZC3HAV1 -0.432111642767632 0.000159764714931007 0.177804762681042 0.0115795519752419 mirMAP -0.144382627844057 1.05053212214651e-06 NA NA NA hsa-miR-132-3p ZCCHC14 0.323796239695997 0.00272093067935091 -0.499988131084804 9.91660995682074e-07 mirMAP -0.205688848193845 9.51774452434389e-06 NA NA NA hsa-miR-181a-5p ZCCHC2 0.250113435902954 0.0551933249319293 -0.958784652047301 6.66946185116509e-17 mirMAP -0.155041736565727 0.000508875802569447 NA NA NA hsa-miR-181b-5p ZCCHC2 0.488256489401108 0.00105321129419701 -0.958784652047301 6.66946185116509e-17 mirMAP -0.160715602763594 3.25137583319238e-05 NA NA NA hsa-miR-132-3p ZCCHC6 0.323796239695997 0.00272093067935091 -0.805230488151026 1.39663489760061e-09 miRNATAP -0.290861191752392 1.77327334906309e-06 NA NA NA hsa-miR-20a-5p ZDHHC1 0.854326758727003 5.04256669663285e-07 -0.618301483420499 0.0045534659253571 MirTarget;miRNATAP -0.368953726193122 1.34601303638492e-09 NA NA NA hsa-miR-15a-5p ZDHHC15 0.349521211668244 0.000770735998804736 -1.05212931450714 4.19710859293851e-05 MirTarget -0.334888147486829 0.00606326306888716 NA NA NA hsa-miR-19b-3p ZDHHC15 0.601279551368824 0.00016685097085251 -1.05212931450714 4.19710859293851e-05 miRNATAP -0.254427598302818 0.00119843591271717 NA NA NA hsa-miR-21-5p ZDHHC17 1.51084295924322 1.54551622173259e-34 -0.16799106872775 0.0488926508637065 miRNATAP -0.128394985020913 3.10775657611721e-05 NA NA NA hsa-miR-34a-5p ZDHHC17 1.03694231790865 5.74864019540594e-14 -0.16799106872775 0.0488926508637065 MirTarget;miRNATAP -0.105793437347076 0.000275647029482819 NA NA NA hsa-miR-192-5p ZDHHC2 -0.50188499512787 0.00344713341196035 -1.00761289977392 6.32790244881183e-07 miRNAWalker2_validate;MirTarget -0.194580660815328 0.000787838638573794 NA NA NA hsa-miR-19b-3p ZDHHC2 0.601279551368824 0.00016685097085251 -1.00761289977392 6.32790244881183e-07 mirMAP -0.170714890576748 0.00609717937632214 NA NA NA hsa-miR-224-3p ZDHHC2 1.40770116795301 1.31426607144612e-08 -1.00761289977392 6.32790244881183e-07 mirMAP -0.126114507471233 0.00164598492348003 NA NA NA hsa-miR-30b-5p ZDHHC20 -0.54056186708617 2.44688760798341e-05 -0.850359370338993 0.00305845004418993 MirTarget -0.320294042567598 0.00334750855315162 NA NA NA hsa-miR-148a-3p ZDHHC23 -0.748702855596996 3.93313343865641e-07 0.31113543845786 0.027353194603354 MirTarget -0.193066199183344 2.48865332154847e-05 NA NA NA hsa-miR-15a-5p ZDHHC23 0.349521211668244 0.000770735998804736 0.31113543845786 0.027353194603354 MirTarget -0.149788666150553 0.0243643714423185 NA NA NA hsa-miR-34a-5p ZDHHC23 1.03694231790865 5.74864019540594e-14 0.31113543845786 0.027353194603354 miRNATAP -0.125185361723646 0.00979114782181029 NA NA NA hsa-miR-148a-3p ZDHHC7 -0.748702855596996 3.93313343865641e-07 0.0927070329222683 0.321096181728645 MirTarget;miRNATAP -0.348656796446493 6.48216350335255e-36 NA NA NA hsa-miR-15a-5p ZDHHC8 0.349521211668244 0.000770735998804736 -0.184074121122863 0.248060260599179 mirMAP -0.150079604294241 0.0457054968302458 NA NA NA hsa-miR-192-3p ZEB2 -0.6401165114007 0.000266272092403814 -1.50896689448163 2.21480558222559e-19 MirTarget -0.295642548158906 5.13579499161447e-10 NA NA NA hsa-miR-192-5p ZEB2 -0.50188499512787 0.00344713341196035 -1.50896689448163 2.21480558222559e-19 MirTarget;miRNATAP -0.325488676967802 2.20421079157058e-11 NA NA NA hsa-miR-19b-3p ZEB2 0.601279551368824 0.00016685097085251 -1.50896689448163 2.21480558222559e-19 miRNATAP -0.234905876662482 8.96880644411667e-06 NA NA NA hsa-miR-221-3p ZEB2 1.12244756358612 3.48370308238012e-13 -1.50896689448163 2.21480558222559e-19 miRNAWalker2_validate;MirTarget;miRNATAP -0.182551774312563 0.000690586802131325 NA NA NA hsa-miR-455-5p ZEB2 -0.270546034117157 0.0581320703577731 -1.50896689448163 2.21480558222559e-19 miRanda -0.311857815728672 1.48287293421499e-07 NA NA NA hsa-miR-30c-5p ZFAND1 -0.432111642767632 0.000159764714931007 0.0342370355978074 0.717442943605464 MirTarget -0.122120648903613 0.00230125125215377 NA NA NA hsa-miR-30e-5p ZFAND1 -0.627815042856657 3.02205690184908e-10 0.0342370355978074 0.717442943605464 MirTarget -0.115447517663705 0.0112173805957496 NA NA NA hsa-miR-19b-3p ZFAND5 0.601279551368824 0.00016685097085251 -0.89687020061194 5.59442964172277e-08 miRNAWalker2_validate -0.185151241199888 0.000264324436804183 NA NA NA hsa-miR-20a-5p ZFAND5 0.854326758727003 5.04256669663285e-07 -0.89687020061194 5.59442964172277e-08 mirMAP -0.182867722857365 0.000110197600724576 NA NA NA hsa-miR-15a-5p ZFHX3 0.349521211668244 0.000770735998804736 -0.0942819103546988 0.299802511049548 MirTarget;miRNATAP -0.1242893666382 0.00353087607818301 NA NA NA hsa-miR-181a-5p ZFHX4 0.250113435902954 0.0551933249319293 -0.832628706674559 7.07667307978028e-05 MirTarget;mirMAP;miRNATAP -0.191615784798454 0.0157002945465338 NA NA NA hsa-miR-181b-5p ZFHX4 0.488256489401108 0.00105321129419701 -0.832628706674559 7.07667307978028e-05 MirTarget;mirMAP;miRNATAP -0.257656077878309 0.000174853767443786 NA NA NA hsa-miR-146b-5p ZFP28 0.419719546795449 0.0457375823220155 -0.277907249259473 0.192279433932427 miRanda -0.120672919121306 0.0146115922371441 NA NA NA hsa-miR-146b-5p ZFP3 0.419719546795449 0.0457375823220155 -1.22908823820342 1.44462211407611e-07 miRanda -0.223967429990134 4.20209959878974e-05 NA NA NA hsa-miR-181a-5p ZFP36L1 0.250113435902954 0.0551933249319293 -1.16699812240509 1.50804518778222e-27 miRNATAP -0.108179137398542 0.0119027230356697 NA NA NA hsa-miR-181b-5p ZFP36L1 0.488256489401108 0.00105321129419701 -1.16699812240509 1.50804518778222e-27 miRNATAP -0.132009668030417 0.000398170174799281 NA NA NA hsa-miR-21-5p ZFP36L2 1.51084295924322 1.54551622173259e-34 -0.368277506129601 0.000489675160959715 MirTarget -0.126203314684949 0.00107280663992073 NA NA NA hsa-miR-29c-3p ZFP41 -1.4367517608807 1.61767774905781e-21 1.68571425193753 7.24184178265088e-33 mirMAP -0.320288907741131 3.1273303189608e-12 NA NA NA hsa-miR-505-5p ZFP41 -0.768282569967001 1.14662846595407e-05 1.68571425193753 7.24184178265088e-33 mirMAP -0.165361929832174 8.28951796327716e-05 NA NA NA hsa-miR-19b-3p ZFP91 0.601279551368824 0.00016685097085251 -0.225485146491446 0.00482633262124725 miRNATAP -0.100468442452636 3.08684941467151e-05 NA NA NA hsa-miR-20a-5p ZFP91 0.854326758727003 5.04256669663285e-07 -0.225485146491446 0.00482633262124725 MirTarget;miRNATAP -0.11317908809573 4.2408914804633e-07 NA NA NA hsa-miR-30b-5p ZFP91 -0.54056186708617 2.44688760798341e-05 -0.225485146491446 0.00482633262124725 MirTarget -0.106712700575428 0.000405063859556243 NA NA NA hsa-miR-146b-5p ZFPM2 0.419719546795449 0.0457375823220155 -2.22408950189141 1.94401967403455e-22 miRanda -0.175204183265854 0.00168003808563049 NA NA NA hsa-miR-148a-3p ZFPM2 -0.748702855596996 3.93313343865641e-07 -2.22408950189141 1.94401967403455e-22 miRNATAP -0.168857556123059 0.0322360782737704 NA NA NA hsa-miR-19b-3p ZFPM2 0.601279551368824 0.00016685097085251 -2.22408950189141 1.94401967403455e-22 miRNATAP -0.346944789690712 1.71248833178892e-06 NA NA NA hsa-miR-20a-5p ZFPM2 0.854326758727003 5.04256669663285e-07 -2.22408950189141 1.94401967403455e-22 miRNATAP -0.440517313452057 4.28744144255194e-11 NA NA NA hsa-miR-221-3p ZFPM2 1.12244756358612 3.48370308238012e-13 -2.22408950189141 1.94401967403455e-22 miRNATAP -0.46799720845663 1.13002039335422e-10 NA NA NA hsa-miR-222-3p ZFPM2 1.08574156066353 1.76407192348131e-11 -2.22408950189141 1.94401967403455e-22 miRNATAP -0.385845279837584 3.71622086421668e-08 NA NA NA hsa-miR-455-5p ZFPM2 -0.270546034117157 0.0581320703577731 -2.22408950189141 1.94401967403455e-22 miRanda;miRNATAP -0.213947590671196 0.00952994830547844 NA NA NA hsa-miR-146b-5p ZFX 0.419719546795449 0.0457375823220155 -0.288944862404029 0.0232109254931894 miRanda;mirMAP;miRNATAP -0.107772108836844 0.000246509762559999 NA NA NA hsa-miR-127-3p ZFY -1.0751374948053 2.19322892330221e-05 0.133807960077019 0.824120740455296 miRanda -0.225651415527097 0.0493770199062608 NA NA NA hsa-miR-30c-5p ZFY -0.432111642767632 0.000159764714931007 0.133807960077019 0.824120740455296 MirTarget -0.529521391137452 0.0391685645119105 NA NA NA hsa-miR-132-3p ZFYVE1 0.323796239695997 0.00272093067935091 -0.297630853530194 0.000518727671832388 miRNATAP -0.193779952504459 4.88881390613263e-07 NA NA NA hsa-miR-20a-5p ZFYVE21 0.854326758727003 5.04256669663285e-07 -0.507343806467437 4.4231530346861e-09 miRNATAP -0.174498640052848 5.70124909699998e-13 NA NA NA hsa-miR-30b-5p ZFYVE26 -0.54056186708617 2.44688760798341e-05 0.731504249335683 5.96293614718717e-19 miRNATAP -0.182144974734536 1.24009353393538e-08 NA NA NA hsa-miR-19b-3p ZFYVE9 0.601279551368824 0.00016685097085251 -0.342162134568488 0.000131097224279702 MirTarget;miRNATAP -0.122904614326875 5.52992723661209e-06 NA NA NA hsa-miR-20a-5p ZFYVE9 0.854326758727003 5.04256669663285e-07 -0.342162134568488 0.000131097224279702 MirTarget;miRNATAP -0.14106974348761 1.81731985175181e-08 NA NA NA hsa-miR-222-3p ZFYVE9 1.08574156066353 1.76407192348131e-11 -0.342162134568488 0.000131097224279702 miRNAWalker2_validate -0.111055700895238 2.43473696929075e-05 NA NA NA hsa-miR-146a-5p ZHX3 -0.742958238440575 0.000765983177482633 -0.0728476988937654 0.495793402490393 mirMAP -0.19777437897373 1.21158787136182e-18 NA NA NA hsa-miR-19b-3p ZHX3 0.601279551368824 0.00016685097085251 -0.0728476988937654 0.495793402490393 mirMAP -0.106361210098732 0.000989996349067709 NA NA NA hsa-miR-20a-5p ZHX3 0.854326758727003 5.04256669663285e-07 -0.0728476988937654 0.495793402490393 mirMAP -0.124549602671161 3.3127133818874e-05 NA NA NA hsa-miR-222-3p ZHX3 1.08574156066353 1.76407192348131e-11 -0.0728476988937654 0.495793402490393 mirMAP -0.26405531770803 2.08132759018697e-18 NA NA NA hsa-miR-30c-5p ZIC2 -0.432111642767632 0.000159764714931007 5.55427609991254 2.4522992307337e-33 miRNATAP -0.574180732505794 0.00721929227495083 NA NA NA hsa-miR-132-3p ZKSCAN1 0.323796239695997 0.00272093067935091 -0.0531372621259427 0.752266920384968 mirMAP -0.264309572282208 0.000502164679500779 NA NA NA hsa-miR-30b-5p ZKSCAN1 -0.54056186708617 2.44688760798341e-05 -0.0531372621259427 0.752266920384968 mirMAP -0.15002453212276 0.0185910361031585 NA NA NA hsa-miR-15a-5p ZMAT3 0.349521211668244 0.000770735998804736 -0.69014006285696 7.01619041120993e-05 MirTarget -0.318244124153394 0.000104023189915145 NA NA NA hsa-miR-19b-3p ZMAT3 0.601279551368824 0.00016685097085251 -0.69014006285696 7.01619041120993e-05 MirTarget -0.320735074486577 7.82081530608916e-10 NA NA NA hsa-miR-20a-5p ZMAT3 0.854326758727003 5.04256669663285e-07 -0.69014006285696 7.01619041120993e-05 mirMAP -0.279960410353906 9.5889879711568e-09 NA NA NA hsa-miR-20b-5p ZMAT3 0.457668023910379 0.0285865211936156 -0.69014006285696 7.01619041120993e-05 mirMAP -0.157885774368395 9.79108265057953e-05 NA NA NA hsa-miR-34a-5p ZMIZ1 1.03694231790865 5.74864019540594e-14 0.105313799919093 0.360093862824644 mirMAP -0.184743003469498 2.23173142442542e-06 NA NA NA hsa-miR-192-3p ZMIZ2 -0.6401165114007 0.000266272092403814 0.699655330406122 2.05296958871649e-18 mirMAP -0.109731172537941 1.388600431875e-06 NA NA NA hsa-miR-29c-3p ZMYM3 -1.4367517608807 1.61767774905781e-21 0.569841663388038 1.22836361242555e-10 MirTarget -0.264505943866572 8.06355792455264e-24 NA NA NA hsa-miR-19b-3p ZMYND11 0.601279551368824 0.00016685097085251 -0.222088828059046 0.00435961360891543 MirTarget;miRNATAP -0.123438543414262 1.20724910115057e-07 NA NA NA hsa-miR-146b-5p ZNF136 0.419719546795449 0.0457375823220155 -0.273076689197678 0.0145435802847022 MirTarget;miRanda -0.120440651867482 2.71631620288118e-06 NA NA NA hsa-miR-27b-3p ZNF207 -0.823491817819754 9.20935302746823e-14 0.476017454845254 1.69423309001909e-17 mirMAP -0.106393017895663 1.61926010616278e-05 NA NA NA hsa-miR-192-5p ZNF215 -0.50188499512787 0.00344713341196035 -0.017805184787929 0.954311069166935 miRNAWalker2_validate -0.361792049361037 3.53769318097667e-05 NA NA NA hsa-miR-192-5p ZNF226 -0.50188499512787 0.00344713341196035 0.398458396409257 0.000116569338540428 miRNAWalker2_validate -0.105832789571644 0.000310931043186551 NA NA NA hsa-miR-27b-3p ZNF226 -0.823491817819754 9.20935302746823e-14 0.398458396409257 0.000116569338540428 mirMAP -0.106502981001398 0.0174402392081609 NA NA NA hsa-miR-146b-5p ZNF229 0.419719546795449 0.0457375823220155 -0.0355308841724548 0.903067097202551 miRanda -0.135956529016638 0.0445539642480794 NA NA NA hsa-miR-21-5p ZNF24 1.51084295924322 1.54551622173259e-34 -0.418019959917853 3.16023417649809e-11 mirMAP -0.166170110277504 2.59599760704008e-13 NA NA NA hsa-miR-194-5p ZNF25 -0.292530160992458 0.0996141384876663 -0.0325069960638196 0.743673131785917 miRNATAP -0.125358938748127 3.30493350541426e-06 NA NA NA hsa-miR-19b-3p ZNF25 0.601279551368824 0.00016685097085251 -0.0325069960638196 0.743673131785917 mirMAP -0.163677661032103 3.37722449221478e-08 NA NA NA hsa-miR-20a-5p ZNF25 0.854326758727003 5.04256669663285e-07 -0.0325069960638196 0.743673131785917 miRNATAP -0.191684104663972 2.40053471367193e-12 NA NA NA hsa-miR-146b-5p ZNF253 0.419719546795449 0.0457375823220155 0.294978236955333 0.0184073373297236 MirTarget;miRanda -0.125758393893649 1.26915642568716e-05 NA NA NA hsa-miR-146b-5p ZNF254 0.419719546795449 0.0457375823220155 -0.523499667824194 0.00058213648009003 miRanda -0.11504110756135 0.00114556326577551 NA NA NA hsa-miR-192-5p ZNF267 -0.50188499512787 0.00344713341196035 0.126790283339464 0.175258122372413 miRNAWalker2_validate -0.144650552001258 2.78542220435761e-08 NA NA NA hsa-miR-181a-5p ZNF268 0.250113435902954 0.0551933249319293 -0.593152337415467 2.02863291106211e-05 MirTarget -0.115860198896497 0.0280216162061487 NA NA NA hsa-miR-181b-5p ZNF268 0.488256489401108 0.00105321129419701 -0.593152337415467 2.02863291106211e-05 MirTarget -0.10406262423761 0.0232743506727264 NA NA NA hsa-miR-192-5p ZNF273 -0.50188499512787 0.00344713341196035 0.827625040045322 1.67244417517975e-08 miRNAWalker2_validate -0.160569079152304 0.000135865747472366 NA NA NA hsa-miR-29c-3p ZNF28 -1.4367517608807 1.61767774905781e-21 0.306989270346882 0.257786445321441 MirTarget -0.324658441979837 9.252100217528e-05 NA NA NA hsa-miR-34a-5p ZNF281 1.03694231790865 5.74864019540594e-14 -0.492556695059223 0.0310933072517825 MirTarget;miRNATAP -0.19501174654901 0.0131294526679534 NA NA NA hsa-miR-29c-3p ZNF282 -1.4367517608807 1.61767774905781e-21 0.716140442901994 5.69756003400774e-20 MirTarget;miRNATAP -0.17863625505552 2.83124584699373e-13 NA NA NA hsa-miR-192-5p ZNF320 -0.50188499512787 0.00344713341196035 0.694463824214256 0.00996574099271424 miRNAWalker2_validate -0.331429833104643 1.31685798483608e-05 NA NA NA hsa-miR-21-5p ZNF326 1.51084295924322 1.54551622173259e-34 -0.426269705905494 6.21862215532185e-08 miRNAWalker2_validate -0.17477153056191 9.01092351909685e-10 NA NA NA hsa-miR-29c-3p ZNF346 -1.4367517608807 1.61767774905781e-21 0.50201482926775 2.29175498618488e-11 MirTarget -0.14216099469425 8.0035562081703e-10 NA NA NA hsa-miR-21-5p ZNF367 1.51084295924322 1.54551622173259e-34 -0.513348841626488 0.00175456475987379 miRNAWalker2_validate;miRNATAP -0.286148705844577 1.52740310844254e-06 NA NA NA hsa-miR-27b-3p ZNF385A -0.823491817819754 9.20935302746823e-14 0.146869024759309 0.313794922625405 miRNATAP -0.160966936151999 0.0102758937593206 NA NA NA hsa-miR-132-3p ZNF395 0.323796239695997 0.00272093067935091 -0.655052364497288 2.2684162658962e-08 miRNATAP -0.244468812627852 4.90756743833299e-06 NA NA NA hsa-miR-181a-5p ZNF396 0.250113435902954 0.0551933249319293 0.253036000851592 0.0549603177822499 miRNATAP -0.223518478507878 5.18155198108874e-06 NA NA NA hsa-miR-181b-5p ZNF396 0.488256489401108 0.00105321129419701 0.253036000851592 0.0549603177822499 miRNATAP -0.196847105189002 3.92416278217083e-06 NA NA NA hsa-miR-146b-5p ZNF41 0.419719546795449 0.0457375823220155 -0.299338758280992 0.00285805574232575 miRanda -0.120680130278592 1.55575327379417e-07 NA NA NA hsa-miR-146b-5p ZNF418 0.419719546795449 0.0457375823220155 0.00915024013614721 0.969567892716724 miRanda -0.171596425662789 0.00196827336327062 NA NA NA hsa-miR-15a-5p ZNF423 0.349521211668244 0.000770735998804736 -0.0193608514881518 0.924397085233393 miRNATAP -0.401294598844424 2.57112472776673e-05 NA NA NA hsa-miR-17-3p ZNF423 0.410352776142368 0.00422200500748636 -0.0193608514881518 0.924397085233393 miRNAWalker2_validate;MirTarget;miRNATAP -0.273217154357005 7.30213614602951e-05 NA NA NA hsa-miR-455-3p ZNF423 -1.3998033821095 5.72010709806871e-17 -0.0193608514881518 0.924397085233393 mirMAP -0.175855131207301 0.00206313369626561 NA NA NA hsa-miR-192-5p ZNF449 -0.50188499512787 0.00344713341196035 0.731857019114456 1.65613647215576e-14 miRNAWalker2_validate -0.113010234538614 4.51669954177748e-05 NA NA NA hsa-miR-132-3p ZNF451 0.323796239695997 0.00272093067935091 0.00667997245057173 0.935667435375475 MirTarget -0.16382495778773 9.6275690024007e-06 NA NA NA hsa-miR-181b-5p ZNF451 0.488256489401108 0.00105321129419701 0.00667997245057173 0.935667435375475 mirMAP -0.103631073127578 0.000105330048525823 NA NA NA hsa-miR-21-5p ZNF451 1.51084295924322 1.54551622173259e-34 0.00667997245057173 0.935667435375475 mirMAP -0.142196739648657 1.72736524516026e-06 NA NA NA hsa-miR-17-3p ZNF462 0.410352776142368 0.00422200500748636 -1.49325540515818 3.31882201026181e-09 MirTarget -0.493550121755515 1.02049618623758e-08 NA NA NA hsa-miR-146b-5p ZNF467 0.419719546795449 0.0457375823220155 0.677500592947488 0.00120451179207406 miRanda -0.105368094029807 0.0308595525283062 NA NA NA hsa-miR-29c-3p ZNF468 -1.4367517608807 1.61767774905781e-21 0.438299594431106 0.0969168606367628 MirTarget -0.373765281982936 3.52846718380645e-06 NA NA NA hsa-miR-19b-3p ZNF469 0.601279551368824 0.00016685097085251 -0.525222123924474 0.015528259270098 miRNATAP -0.134197626175035 0.042592811413413 NA NA NA hsa-miR-146b-5p ZNF471 0.419719546795449 0.0457375823220155 -1.02445139017411 0.000664294071232151 miRanda -0.206789657422254 0.00318149896579957 NA NA NA hsa-miR-146b-5p ZNF493 0.419719546795449 0.0457375823220155 0.129748322852176 0.408574147773814 MirTarget;miRanda -0.124909769814324 0.000564660430546777 NA NA NA hsa-miR-181b-5p ZNF503 0.488256489401108 0.00105321129419701 0.22587365787045 0.232944065367825 miRNAWalker2_validate -0.324352633058089 1.04751327918961e-07 NA NA NA hsa-miR-29c-3p ZNF512B -1.4367517608807 1.61767774905781e-21 0.949756749303405 1.79541489585724e-18 MirTarget;miRNATAP -0.257346727252607 2.27055818185701e-14 NA NA NA hsa-miR-192-5p ZNF519 -0.50188499512787 0.00344713341196035 0.767968415320557 0.000120210160797392 miRNAWalker2_validate -0.171072696299973 0.00266692177589701 NA NA NA hsa-miR-19b-3p ZNF521 0.601279551368824 0.00016685097085251 -0.124196566648493 0.549078463449505 miRNAWalker2_validate;MirTarget;miRNATAP -0.242689722246346 0.000105413380737763 NA NA NA hsa-miR-455-5p ZNF521 -0.270546034117157 0.0581320703577731 -0.124196566648493 0.549078463449505 miRanda -0.268576894231406 0.000141297847055729 NA NA NA hsa-miR-146b-5p ZNF527 0.419719546795449 0.0457375823220155 0.260675782849676 0.00547326878026242 miRanda -0.121002436820161 1.63484333663765e-08 NA NA NA hsa-miR-21-5p ZNF527 1.51084295924322 1.54551622173259e-34 0.260675782849676 0.00547326878026242 MirTarget -0.105578034047756 0.00200976037321645 NA NA NA hsa-miR-194-5p ZNF532 -0.292530160992458 0.0996141384876663 0.726511739143307 7.11049790812266e-06 miRNATAP -0.451331225457648 9.29510316869024e-27 NA NA NA hsa-miR-29c-3p ZNF532 -1.4367517608807 1.61767774905781e-21 0.726511739143307 7.11049790812266e-06 miRNATAP -0.207533269799687 3.29779518093572e-05 NA NA NA hsa-miR-34a-5p ZNF532 1.03694231790865 5.74864019540594e-14 0.726511739143307 7.11049790812266e-06 miRNATAP -0.22038335850107 7.92724550200979e-05 NA NA NA hsa-miR-30b-5p ZNF543 -0.54056186708617 2.44688760798341e-05 0.556824467835664 7.98084169422398e-07 miRNAWalker2_validate -0.112008454848123 0.00958522261051057 NA NA NA hsa-miR-146b-5p ZNF550 0.419719546795449 0.0457375823220155 0.658482767117193 9.06419487762518e-05 miRanda -0.104639139503888 0.00771638748023071 NA NA NA hsa-miR-30b-5p ZNF555 -0.54056186708617 2.44688760798341e-05 0.737605578319765 7.84990681060634e-11 mirMAP -0.105616500499463 0.0162841522663479 NA NA NA hsa-miR-181a-5p ZNF563 0.250113435902954 0.0551933249319293 0.853469338413236 4.82981330058587e-08 MirTarget;miRNATAP -0.117795206930569 0.0485635726418697 NA NA NA hsa-miR-181b-5p ZNF563 0.488256489401108 0.00105321129419701 0.853469338413236 4.82981330058587e-08 MirTarget;miRNATAP -0.176860351950483 0.000625364727112428 NA NA NA hsa-miR-146b-5p ZNF578 0.419719546795449 0.0457375823220155 0.426857621629919 0.0773223849343733 miRanda -0.123256648356599 0.0280818254832656 NA NA NA hsa-miR-148a-3p ZNF587 -0.748702855596996 3.93313343865641e-07 0.416605076067025 0.000245987062294619 mirMAP -0.132400344546222 0.000367574330535695 NA NA NA hsa-miR-132-3p ZNF599 0.323796239695997 0.00272093067935091 0.246543441388938 0.0661233820710823 mirMAP -0.183321750047841 0.00253531213775728 NA NA NA hsa-miR-15a-5p ZNF609 0.349521211668244 0.000770735998804736 -0.0859843237574855 0.336266324021442 miRNATAP -0.111373149502544 0.00789334940339564 NA NA NA hsa-miR-192-5p ZNF611 -0.50188499512787 0.00344713341196035 -0.0290277091796842 0.902176684001182 miRNAWalker2_validate -0.20875613485153 0.00176386318068331 NA NA NA hsa-miR-146b-5p ZNF618 0.419719546795449 0.0457375823220155 0.943831859691578 2.40047580237559e-12 mirMAP -0.105043619930327 0.00102135559334278 NA NA NA hsa-miR-148a-3p ZNF618 -0.748702855596996 3.93313343865641e-07 0.943831859691578 2.40047580237559e-12 miRNATAP -0.390230443941614 1.78915488594973e-19 NA NA NA hsa-miR-505-5p ZNF618 -0.768282569967001 1.14662846595407e-05 0.943831859691578 2.40047580237559e-12 mirMAP -0.187711383612129 6.65624107576444e-07 NA NA NA hsa-miR-146b-5p ZNF626 0.419719546795449 0.0457375823220155 -0.526102055720171 0.0264531004023447 miRanda -0.23747096737416 1.39083660805816e-05 NA NA NA hsa-miR-34a-5p ZNF641 1.03694231790865 5.74864019540594e-14 -0.540165425946128 0.00398674479500119 MirTarget -0.220709033075154 0.000617950564452846 NA NA NA hsa-miR-455-5p ZNF641 -0.270546034117157 0.0581320703577731 -0.540165425946128 0.00398674479500119 miRanda -0.184331948254232 0.00420648283310658 NA NA NA hsa-miR-132-3p ZNF644 0.323796239695997 0.00272093067935091 -0.272949227471648 0.00122760363679238 MirTarget;miRNATAP -0.119950237361867 0.00170858291609346 NA NA NA hsa-miR-30b-5p ZNF646 -0.54056186708617 2.44688760798341e-05 0.88201193364562 2.040000263053e-25 miRNAWalker2_validate -0.101259712360711 0.00287539434586587 NA NA NA hsa-miR-146b-5p ZNF649 0.419719546795449 0.0457375823220155 -0.792797838357691 3.5371205816942e-06 MirTarget;miRanda -0.144575746699996 0.000293080240945044 NA NA NA hsa-miR-132-3p ZNF652 0.323796239695997 0.00272093067935091 0.169367285673935 0.0353229494109345 miRNAWalker2_validate;MirTarget -0.174662740384976 1.2214137142449e-06 NA NA NA hsa-miR-181a-5p ZNF652 0.250113435902954 0.0551933249319293 0.169367285673935 0.0353229494109345 miRNAWalker2_validate -0.144950577436389 1.1393094376828e-06 NA NA NA hsa-miR-181a-5p ZNF654 0.250113435902954 0.0551933249319293 -0.621209689571205 1.69740975453914e-13 MirTarget -0.121717379361359 0.000167418786368602 NA NA NA hsa-miR-181b-5p ZNF654 0.488256489401108 0.00105321129419701 -0.621209689571205 1.69740975453914e-13 MirTarget -0.121792650181654 1.41505866216099e-05 NA NA NA hsa-miR-21-5p ZNF654 1.51084295924322 1.54551622173259e-34 -0.621209689571205 1.69740975453914e-13 miRNATAP -0.284418544182187 3.24854923597832e-21 NA NA NA hsa-miR-148a-3p ZNF665 -0.748702855596996 3.93313343865641e-07 -0.0424406995812787 0.875598989998811 MirTarget -0.24526069818326 0.00555092355538439 NA NA NA hsa-miR-21-5p ZNF667 1.51084295924322 1.54551622173259e-34 -0.675731521836621 0.0246747711488253 miRNAWalker2_validate -0.410646134854514 0.000176940975400381 NA NA NA hsa-miR-146b-5p ZNF676 0.419719546795449 0.0457375823220155 0.831715712452062 0.0422319137209506 MirTarget;miRanda -0.190441176961273 0.0455535930564101 NA NA NA hsa-miR-146b-5p ZNF678 0.419719546795449 0.0457375823220155 0.072393209142431 0.705898860518039 miRanda -0.179139850786077 4.96088806175111e-05 NA NA NA hsa-miR-455-3p ZNF678 -1.3998033821095 5.72010709806871e-17 0.072393209142431 0.705898860518039 MirTarget -0.126832874608847 0.0183840960413597 NA NA NA hsa-miR-21-5p ZNF680 1.51084295924322 1.54551622173259e-34 -0.548304197900761 0.000339937850652107 MirTarget -0.407989154462753 7.3992267622587e-14 NA NA NA hsa-miR-30b-5p ZNF680 -0.54056186708617 2.44688760798341e-05 -0.548304197900761 0.000339937850652107 mirMAP -0.152553507886769 0.00891137050348109 NA NA NA hsa-miR-30b-5p ZNF681 -0.54056186708617 2.44688760798341e-05 1.36344440019153 1.01462119013725e-06 mirMAP -0.33342987399061 0.00181939810540075 NA NA NA hsa-miR-30c-5p ZNF687 -0.432111642767632 0.000159764714931007 0.891394616348857 6.96466234164512e-16 miRNAWalker2_validate -0.123518912043863 0.0112724254051343 NA NA NA hsa-miR-146b-5p ZNF689 0.419719546795449 0.0457375823220155 -0.455196300000523 0.0174993323919554 miRanda -0.122141436743972 0.00602458105097536 NA NA NA hsa-miR-146b-5p ZNF701 0.419719546795449 0.0457375823220155 0.0789677403634204 0.717148346237302 mirMAP -0.120490235912861 0.0170410505994009 NA NA NA hsa-miR-192-3p ZNF701 -0.6401165114007 0.000266272092403814 0.0789677403634204 0.717148346237302 mirMAP -0.223490329233986 0.000190011453484281 NA NA NA hsa-miR-192-5p ZNF701 -0.50188499512787 0.00344713341196035 0.0789677403634204 0.717148346237302 miRNAWalker2_validate -0.249642377925715 4.73111216887737e-05 NA NA NA hsa-miR-192-5p ZNF704 -0.50188499512787 0.00344713341196035 -0.0623150478884346 0.775934225421731 miRNAWalker2_validate -0.214223153375824 0.000527010703395638 NA NA NA hsa-miR-19b-3p ZNF704 0.601279551368824 0.00016685097085251 -0.0623150478884346 0.775934225421731 miRNATAP -0.182120512024807 0.00608776719363071 NA NA NA hsa-miR-20a-5p ZNF704 0.854326758727003 5.04256669663285e-07 -0.0623150478884346 0.775934225421731 miRNATAP -0.201664569778215 0.00110311021623084 NA NA NA hsa-miR-455-5p ZNF704 -0.270546034117157 0.0581320703577731 -0.0623150478884346 0.775934225421731 miRNATAP -0.178045472589384 0.0174848125071008 NA NA NA hsa-miR-192-5p ZNF710 -0.50188499512787 0.00344713341196035 0.313248196006383 0.103373907581206 mirMAP -0.112345630849099 0.0396613229855268 NA NA NA hsa-miR-455-5p ZNF711 -0.270546034117157 0.0581320703577731 -0.0288932356090779 0.926637499360174 miRanda -0.289944147893315 0.00689760645155676 NA NA NA hsa-miR-27b-3p ZNF746 -0.823491817819754 9.20935302746823e-14 0.504549701393687 1.81855502334155e-07 MirTarget -0.138634682295428 0.000979547390864537 NA NA NA hsa-miR-30c-5p ZNF746 -0.432111642767632 0.000159764714931007 0.504549701393687 1.81855502334155e-07 MirTarget -0.119043997796888 0.00426733293829077 NA NA NA hsa-miR-30e-5p ZNF746 -0.627815042856657 3.02205690184908e-10 0.504549701393687 1.81855502334155e-07 MirTarget -0.148421017582376 0.00166742239796983 NA NA NA hsa-miR-181b-5p ZNF747 0.488256489401108 0.00105321129419701 -0.335136007141183 0.000287797653513016 miRNAWalker2_validate -0.214005619442387 3.66641898151081e-13 NA NA NA hsa-miR-181b-5p ZNF75D 0.488256489401108 0.00105321129419701 0.00169595616856633 0.986510624932447 mirMAP -0.107799805001994 0.000918834207854721 NA NA NA hsa-miR-29c-3p ZNF761 -1.4367517608807 1.61767774905781e-21 0.572046131811838 0.000884909207862784 MirTarget -0.361829638088677 3.1438209175722e-12 NA NA NA hsa-miR-222-3p ZNF770 1.08574156066353 1.76407192348131e-11 -0.419927633223283 4.63768336457145e-05 miRNAWalker2_validate -0.156964953706243 2.0664287906554e-07 NA NA NA hsa-miR-146b-5p ZNF793 0.419719546795449 0.0457375823220155 0.580218333297739 0.0247459145794045 mirMAP -0.145942960171454 0.0150866397436864 NA NA NA hsa-miR-192-3p ZNF793 -0.6401165114007 0.000266272092403814 0.580218333297739 0.0247459145794045 mirMAP -0.241596819575382 0.000705625772290356 NA NA NA hsa-miR-181a-5p ZNF800 0.250113435902954 0.0551933249319293 -0.688320107756163 4.23497321998893e-12 MirTarget;miRNATAP -0.100709205852871 0.00836814696916315 NA NA NA hsa-miR-19b-3p ZNF800 0.601279551368824 0.00016685097085251 -0.688320107756163 4.23497321998893e-12 miRNATAP -0.141974961671121 3.61211695036576e-06 NA NA NA hsa-miR-20a-5p ZNF800 0.854326758727003 5.04256669663285e-07 -0.688320107756163 4.23497321998893e-12 MirTarget;miRNATAP -0.17061546891495 1.72543865428922e-09 NA NA NA hsa-miR-148a-3p ZNF821 -0.748702855596996 3.93313343865641e-07 0.740296522200471 1.06023377674518e-11 miRNATAP -0.137566867283079 0.00014914298275068 NA NA NA hsa-miR-17-3p ZNF827 0.410352776142368 0.00422200500748636 -1.01635412446374 0.000468183081986259 miRNATAP -0.240302515900474 0.0156710591157501 NA NA NA hsa-miR-224-3p ZNF831 1.40770116795301 1.31426607144612e-08 -1.16618521835136 6.91838707233374e-06 mirMAP -0.106752063757608 0.0378927162121981 NA NA NA hsa-miR-192-5p ZNF85 -0.50188499512787 0.00344713341196035 1.13012759107508 4.57319672235305e-07 miRNAWalker2_validate -0.241934278219612 0.000161394543061707 NA NA NA hsa-miR-215-5p ZNF85 -0.981544773246509 3.14452272477156e-05 1.13012759107508 4.57319672235305e-07 miRNAWalker2_validate -0.109614592363442 0.0185711942196963 NA NA NA hsa-miR-192-3p ZNF862 -0.6401165114007 0.000266272092403814 0.967395608790016 9.5595719875666e-14 mirMAP -0.110539445493651 0.00276545328731543 NA NA NA hsa-miR-192-5p ZNF862 -0.50188499512787 0.00344713341196035 0.967395608790016 9.5595719875666e-14 mirMAP -0.109895159542478 0.00375226819341488 NA NA NA hsa-miR-20a-5p ZNFX1 0.854326758727003 5.04256669663285e-07 -0.0810183940261595 0.387805109153798 miRNAWalker2_validate;MirTarget;miRNATAP -0.279472822473921 8.35634406518181e-30 NA NA NA hsa-miR-181a-5p ZNRF2 0.250113435902954 0.0551933249319293 -0.338839245711862 0.000542965090087702 MirTarget -0.216411955789776 2.34947889879296e-09 NA NA NA hsa-miR-181b-5p ZNRF2 0.488256489401108 0.00105321129419701 -0.338839245711862 0.000542965090087702 MirTarget -0.205933710430854 5.34103000430317e-11 NA NA NA hsa-miR-20b-5p ZNRF3 0.457668023910379 0.0285865211936156 -0.167866805092005 0.391803552621188 mirMAP -0.175347904186162 0.000111382931397669 NA NA NA hsa-miR-148a-3p ZPLD1 -0.748702855596996 3.93313343865641e-07 -1.71908463654629 7.12931687350314e-05 MirTarget -0.890083843046829 1.93662188896187e-10 NA NA NA hsa-miR-181a-5p ZRANB1 0.250113435902954 0.0551933249319293 -0.533805690434926 1.19229356780518e-07 mirMAP -0.102400420238198 0.00751345766236553 NA NA NA hsa-miR-181b-5p ZRANB1 0.488256489401108 0.00105321129419701 -0.533805690434926 1.19229356780518e-07 mirMAP -0.141102512602061 2.02135089502776e-05 NA NA NA hsa-miR-21-5p ZRANB1 1.51084295924322 1.54551622173259e-34 -0.533805690434926 1.19229356780518e-07 miRNAWalker2_validate -0.415103924712192 1.29253349161736e-33 NA NA NA hsa-miR-30b-5p ZSCAN12 -0.54056186708617 2.44688760798341e-05 0.22290505067603 0.0866569405171493 mirMAP -0.107872346550479 0.028743995275835 NA NA NA hsa-miR-146b-5p ZSCAN16 0.419719546795449 0.0457375823220155 1.03772585901107 1.68186094670298e-17 miRanda -0.110508977288696 0.000159883890831721 NA NA NA hsa-miR-20a-5p ZXDA 0.854326758727003 5.04256669663285e-07 -0.478674582528762 0.000372541399840429 MirTarget -0.185835433107564 9.44958365628006e-07 NA NA NA hsa-miR-30b-5p ZXDA -0.54056186708617 2.44688760798341e-05 -0.478674582528762 0.000372541399840429 MirTarget;mirMAP -0.128168145424955 0.012395173418857 NA NA NA hsa-miR-17-3p ZYG11B 0.410352776142368 0.00422200500748636 -0.715499327103507 8.21161432354526e-11 mirMAP -0.224027746437983 2.56131342580242e-09 NA NA NA hsa-miR-21-5p ZYG11B 1.51084295924322 1.54551622173259e-34 -0.715499327103507 8.21161432354526e-11 miRNAWalker2_validate;mirMAP -0.391557188035884 6.60996513323152e-24 NA NA NA