miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-139-5p AKT3 -1.46099200329485 7.85040381494472e-22 0.757395805826156 5.24354425444781e-05 PITA;miRanda -0.204988506808972 7.26517518198736e-05 NA NA NA hsa-miR-15a-5p AKT3 0.783550182002274 2.60699595655907e-11 0.757395805826156 5.24354425444781e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265716982670402 0.000109391971495535 NA NA NA hsa-miR-17-5p AKT3 1.41924888736771 2.75805544953758e-18 0.757395805826156 5.24354425444781e-05 TargetScan;miRNATAP -0.210478431167346 1.46778910374435e-05 NA NA NA hsa-miR-205-3p AKT3 1.2960640797621 5.80786479909147e-11 0.757395805826156 5.24354425444781e-05 mirMAP -0.248708307357298 5.71786142986847e-10 NA NA NA hsa-miR-20a-5p AKT3 1.1531986665452 1.02385132917958e-11 0.757395805826156 5.24354425444781e-05 miRNATAP -0.244010493055021 2.19437052623105e-07 NA NA NA hsa-miR-29b-3p AKT3 -0.110721443686039 0.511264554091106 0.757395805826156 5.24354425444781e-05 miRNATAP -0.255169036216248 1.32894370465011e-07 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-362-3p AKT3 -0.697212068252854 2.61718493418184e-06 0.757395805826156 5.24354425444781e-05 miRanda -0.198442787422331 0.000314248564221821 NA NA NA hsa-miR-362-5p AKT3 0.41089772861323 0.0404254902071382 0.757395805826156 5.24354425444781e-05 PITA;TargetScan;miRNATAP -0.156881795440952 0.000120211641903581 NA NA NA hsa-miR-141-3p ARRB1 0.730011517758706 0.000120338355004032 -0.990899187402933 6.88372429307207e-11 MirTarget -0.235361596621459 1.15945338102369e-11 NA NA NA hsa-miR-148b-5p ARRB1 1.1533193737265 7.26420964688337e-13 -0.990899187402933 6.88372429307207e-11 mirMAP -0.112765966566694 0.00668850207905976 NA NA NA hsa-miR-149-5p ARRB1 0.443278770827687 0.0642022866136881 -0.990899187402933 6.88372429307207e-11 MirTarget -0.172897039720132 4.31875391320071e-10 NA NA NA hsa-miR-200a-3p ARRB1 0.607140814457753 0.00289840524858752 -0.990899187402933 6.88372429307207e-11 MirTarget -0.203264809926654 3.91524824250346e-10 NA NA NA hsa-miR-219a-1-3p ARRB1 0.54812960890496 0.000643480374673536 -0.990899187402933 6.88372429307207e-11 MirTarget -0.251072266835044 1.2504564611636e-09 NA NA NA hsa-miR-296-5p ARRB1 -0.425442682383961 0.0948240114267711 -0.990899187402933 6.88372429307207e-11 MirTarget;miRNATAP -0.115632603909247 1.7788427974233e-05 NA NA NA hsa-miR-324-3p ARRB1 0.867391246413545 3.63808540490361e-10 -0.990899187402933 6.88372429307207e-11 MirTarget -0.271678636250798 1.05665897770918e-08 NA NA NA hsa-miR-331-3p ARRB1 0.906385914819361 4.27653809739414e-11 -0.990899187402933 6.88372429307207e-11 MirTarget;miRNATAP -0.194823935307408 5.07936172537506e-05 NA NA NA hsa-miR-339-5p ARRB1 1.07771430326938 2.45772601859307e-09 -0.990899187402933 6.88372429307207e-11 miRanda -0.207908246607416 1.04463256621291e-08 NA NA NA hsa-miR-455-3p ARRB1 2.68574446868387 4.28975903022818e-42 -0.990899187402933 6.88372429307207e-11 MirTarget -0.158357690053142 3.55327643739777e-07 NA NA NA hsa-miR-550a-5p ARRB1 1.48775474412835 6.14204462566372e-18 -0.990899187402933 6.88372429307207e-11 MirTarget -0.135077616376533 0.000346879030010411 NA NA NA hsa-miR-671-5p ARRB1 1.90920358947989 6.8158317757852e-31 -0.990899187402933 6.88372429307207e-11 MirTarget -0.220745657752502 6.12643179189059e-09 NA NA NA hsa-miR-92a-3p ARRB1 0.994679542307232 1.32587679156217e-16 -0.990899187402933 6.88372429307207e-11 miRNAWalker2_validate -0.376717400450344 2.04342962483612e-12 NA NA NA hsa-let-7a-3p ATF2 0.0966652362351867 0.423761916840503 0.104371396863857 0.473734669024994 MirTarget;mirMAP;miRNATAP -0.203264433681785 0.000111795870563359 NA NA NA hsa-miR-10b-5p ATF2 -0.582989331935508 4.56688330655626e-06 0.104371396863857 0.473734669024994 MirTarget;miRNATAP -0.273722697904369 2.44697310743771e-08 NA NA NA hsa-miR-15a-5p ATF2 0.783550182002274 2.60699595655907e-11 0.104371396863857 0.473734669024994 miRNAWalker2_validate -0.445586009471093 5.23484994441582e-18 NA NA NA hsa-miR-181a-5p ATF2 0.819060835827404 1.38616688310277e-13 0.104371396863857 0.473734669024994 mirMAP;miRNATAP -0.20096756561152 0.000341029724542025 NA NA NA hsa-miR-181b-5p ATF2 0.974255518824355 2.64876280203475e-16 0.104371396863857 0.473734669024994 mirMAP;miRNATAP -0.143240188988564 0.00584341108166169 NA NA NA hsa-miR-19a-3p ATF2 1.35800152353624 2.80940447111944e-12 0.104371396863857 0.473734669024994 MirTarget;miRNATAP -0.265805757469969 8.34429353177816e-18 NA NA NA hsa-miR-19b-3p ATF2 0.538732279378089 0.000622008277870679 0.104371396863857 0.473734669024994 miRNAWalker2_validate;MirTarget;miRNATAP -0.362231701788782 7.48771210013745e-21 NA NA NA hsa-miR-222-3p ATF2 1.08197052578759 2.32604040301699e-14 0.104371396863857 0.473734669024994 MirTarget -0.176026243848901 5.18693517108327e-05 NA NA NA hsa-miR-26b-5p ATF2 -0.254478038884324 0.0285227763044636 0.104371396863857 0.473734669024994 MirTarget;miRNATAP -0.38217827412852 1.1347354511156e-12 21901137 Coordinated regulation of ATF2 by miR 26b in γ irradiated lung cancer cells; Concurrent analysis of time-series mRNA and microRNA profiles uncovered that expression of miR-26b was down regulated and its target activating transcription factor 2 ATF2 mRNA was up regulated in γ-irradiated H1299 cells; IR in miR-26b overexpressed H1299 cells could not induce expression of ATF2; From these results we concluded that IR-induced up-regulation of ATF2 was coordinately enhanced by suppression of miR-26b in lung cancer cells which may enhance the effect of IR in the MAPK signaling pathway lung cancer hsa-miR-29a-5p ATF2 0.323252792625584 0.0370417231222825 0.104371396863857 0.473734669024994 MirTarget;miRNATAP -0.216551920000306 9.1806205494168e-08 NA NA NA hsa-miR-30a-5p ATF2 -1.79779915425811 1.93360169837799e-26 0.104371396863857 0.473734669024994 mirMAP -0.119397648903742 0.000797054500428221 NA NA NA hsa-miR-30b-5p ATF2 -0.400238605368173 0.00346540992719245 0.104371396863857 0.473734669024994 mirMAP -0.323789672145047 9.74767489864219e-13 NA NA NA hsa-miR-30c-5p ATF2 0.021222006155897 0.886366656528128 0.104371396863857 0.473734669024994 mirMAP -0.357138874601189 7.87667906491707e-18 NA NA NA hsa-miR-320a ATF2 0.801356001806321 4.91397101474502e-09 0.104371396863857 0.473734669024994 miRanda -0.153624053512537 0.000767519462097854 NA NA NA hsa-miR-338-3p ATF2 -0.948755228846395 8.99167125682392e-08 0.104371396863857 0.473734669024994 miRanda -0.309897140896372 9.53284637253794e-20 NA NA NA hsa-miR-3607-3p ATF2 1.01377165357363 9.13355519701165e-05 0.104371396863857 0.473734669024994 mirMAP -0.126287135739983 1.5652976223426e-07 NA NA NA hsa-miR-374b-5p ATF2 -0.288413933608091 0.0041474558664058 0.104371396863857 0.473734669024994 miRNAWalker2_validate;mirMAP;miRNATAP -0.238849509375957 0.000158559195775339 NA NA NA hsa-miR-582-5p ATF2 -0.0366995972742474 0.821827119138923 0.104371396863857 0.473734669024994 MirTarget;miRNATAP -0.16855808035157 1.39388138974067e-05 NA NA NA hsa-miR-590-3p ATF2 0.221436901462551 0.0965904764063157 0.104371396863857 0.473734669024994 MirTarget;miRanda;mirMAP;miRNATAP -0.123694465854944 0.00961729064449703 NA NA NA hsa-let-7b-3p BDNF 0.120166961637302 0.299224004314356 0.0408778714112631 0.883450816679916 MirTarget;miRNATAP -0.485153955582307 3.78595524866656e-06 NA NA NA hsa-miR-142-5p BDNF 0.288897753038094 0.0900009317815725 0.0408778714112631 0.883450816679916 mirMAP -0.308543354723933 1.36682819592341e-05 NA NA NA hsa-miR-146b-5p BDNF 0.917975986853978 3.33749259316025e-09 0.0408778714112631 0.883450816679916 miRanda -0.295426001779662 0.000122805573761243 NA NA NA hsa-miR-155-5p BDNF 0.533437622040649 0.00248671179205372 0.0408778714112631 0.883450816679916 miRNATAP -0.22678558150571 0.000944767256917019 NA NA NA hsa-miR-22-3p BDNF 0.00776313533473072 0.926356548861307 0.0408778714112631 0.883450816679916 miRNAWalker2_validate;miRTarBase -0.427506450899018 0.00361347435585047 NA NA NA hsa-miR-29b-1-5p BDNF 1.39669186711325 4.36960953138935e-11 0.0408778714112631 0.883450816679916 mirMAP -0.226952768941406 5.14949172622145e-05 NA NA NA hsa-miR-338-5p BDNF -1.71946558699173 2.62649071488641e-23 0.0408778714112631 0.883450816679916 miRNATAP -0.232361738096582 0.000529367225285524 NA NA NA hsa-miR-365a-3p BDNF 0.446833934952926 0.00233857759218299 0.0408778714112631 0.883450816679916 miRNATAP -0.31502366808888 0.000131395532237701 NA NA NA hsa-miR-424-5p BDNF 1.48125289532143 9.10372985713165e-19 0.0408778714112631 0.883450816679916 MirTarget;miRNATAP -0.283162731321444 4.92699422656507e-05 NA NA NA hsa-miR-146b-5p BRAF 0.917975986853978 3.33749259316025e-09 -0.278461879502222 0.00862922800492509 miRanda -0.198608471305069 5.60541065764218e-12 21874046;26883911;20406109;21537871 Additionally the activation of thyroid most common oncogenes RET/PTC3 and BRAF in PCCL3 cells upregulated miR-146b-5p expression;miR-146b-5p positively regulates migration and invasion of thyroid normal and tumor follicular cells independently from their original mutation either BRAF or RET/PTC through a mechanism that involves the actin cytoskeleton but not an increased capacity of matrix degradation;The miR-146b expression levels in PTCs with BRAF mutation were significantly higher than those without this mutation p < 0.0001;Among BRAF-positive tumors overexpression of miR-146b was associated with aggressive behavior suggesting that it may further refine the prognostic importance of BRAF ;;; thyroid cancer;thyroid cancer;thyroid cancer;thyroid cancer hsa-miR-191-5p BRAF 0.648528205617075 5.59342922179914e-07 -0.278461879502222 0.00862922800492509 miRNAWalker2_validate -0.142799724118867 5.20266670384239e-05 NA NA NA hsa-miR-590-3p BRAF 0.221436901462551 0.0965904764063157 -0.278461879502222 0.00862922800492509 miRanda -0.107424528492695 0.00201203820994774 NA NA NA hsa-miR-27b-3p CACNA1A -0.732682718863563 2.26896143573324e-09 0.798148823308157 0.000400541214072837 MirTarget -0.234421313597383 0.00325906025868075 NA NA NA hsa-let-7a-2-3p CACNA1B 0.00246680275221167 0.991649532156321 2.26047577769852 4.66526246497752e-06 mirMAP -0.335204064736182 0.000345995653837305 NA NA NA hsa-miR-140-3p CACNA1B -0.967453553824782 7.6999446305445e-23 2.26047577769852 4.66526246497752e-06 MirTarget;miRNATAP -0.796867723857545 0.000177976093785636 NA NA NA hsa-miR-3614-5p CACNA1B 0.955957969488529 2.95347675446694e-05 2.26047577769852 4.66526246497752e-06 mirMAP;miRNATAP -0.573638511300993 6.56042009285108e-10 NA NA NA hsa-let-7a-3p CACNA1C 0.0966652362351867 0.423761916840503 0.719670378607149 0.000375621162906313 MirTarget -0.36367353010746 6.77202909811313e-07 NA NA NA hsa-let-7f-1-3p CACNA1C 0.700374242293247 8.65000484720084e-08 0.719670378607149 0.000375621162906313 MirTarget -0.183110690139896 0.00641509759203706 NA NA NA hsa-miR-148b-5p CACNA1C 1.1533193737265 7.26420964688337e-13 0.719670378607149 0.000375621162906313 mirMAP -0.228922694207488 2.546611170992e-05 NA NA NA hsa-miR-149-5p CACNA1C 0.443278770827687 0.0642022866136881 0.719670378607149 0.000375621162906313 MirTarget -0.171822433710296 2.82963236819279e-06 NA NA NA hsa-miR-186-5p CACNA1C 0.353452958261612 0.000145058448579496 0.719670378607149 0.000375621162906313 mirMAP -0.350883331934319 0.000240494636394959 NA NA NA hsa-miR-192-5p CACNA1C 0.380924502586635 0.00986961967409205 0.719670378607149 0.000375621162906313 mirMAP -0.183910200018589 0.0021808914407804 NA NA NA hsa-miR-1976 CACNA1C 0.638808083289405 2.94840228896364e-07 0.719670378607149 0.000375621162906313 MirTarget -0.301191412276501 1.83461464513685e-05 NA NA NA hsa-miR-19a-3p CACNA1C 1.35800152353624 2.80940447111944e-12 0.719670378607149 0.000375621162906313 MirTarget -0.334318574183962 1.60167955054915e-14 NA NA NA hsa-miR-19b-1-5p CACNA1C 0.757034032029085 2.99828133413343e-07 0.719670378607149 0.000375621162906313 MirTarget -0.483268398517784 5.63504033977118e-17 NA NA NA hsa-miR-19b-3p CACNA1C 0.538732279378089 0.000622008277870679 0.719670378607149 0.000375621162906313 MirTarget -0.479649555931592 1.02627363364154e-18 NA NA NA hsa-miR-200b-3p CACNA1C 0.0717138787925347 0.682858087587209 0.719670378607149 0.000375621162906313 MirTarget;TargetScan -0.403020744188939 2.50972657292567e-16 NA NA NA hsa-miR-200c-3p CACNA1C 0.630251054099546 0.000131975031451555 0.719670378607149 0.000375621162906313 MirTarget -0.310737395218999 4.06711638866768e-09 NA NA NA hsa-miR-205-3p CACNA1C 1.2960640797621 5.80786479909147e-11 0.719670378607149 0.000375621162906313 mirMAP -0.422679444043847 8.65543626093328e-24 NA NA NA hsa-miR-26b-5p CACNA1C -0.254478038884324 0.0285227763044636 0.719670378607149 0.000375621162906313 MirTarget;miRNATAP -0.407919298430317 7.63379324152362e-08 NA NA NA hsa-miR-29a-3p CACNA1C -1.26881270980079 2.82496991513463e-22 0.719670378607149 0.000375621162906313 MirTarget -0.207191424157746 0.00146184263585028 NA NA NA hsa-miR-29b-3p CACNA1C -0.110721443686039 0.511264554091106 0.719670378607149 0.000375621162906313 MirTarget -0.392147903332681 2.47745800029925e-14 NA NA NA hsa-miR-30b-5p CACNA1C -0.400238605368173 0.00346540992719245 0.719670378607149 0.000375621162906313 mirMAP -0.465093729316551 2.12295303248097e-13 NA NA NA hsa-miR-30c-5p CACNA1C 0.021222006155897 0.886366656528128 0.719670378607149 0.000375621162906313 mirMAP -0.302746924827628 3.41168191487491e-07 NA NA NA hsa-miR-30d-5p CACNA1C -0.38399848121878 0.000171129616944749 0.719670378607149 0.000375621162906313 mirMAP -0.305952144969268 0.000425924451086433 NA NA NA hsa-miR-30e-5p CACNA1C -1.02114836019762 6.81961221797866e-17 0.719670378607149 0.000375621162906313 mirMAP -0.316566151095296 6.35457135445227e-06 NA NA NA hsa-miR-320a CACNA1C 0.801356001806321 4.91397101474502e-09 0.719670378607149 0.000375621162906313 miRNATAP -0.273142849005883 1.75865562859355e-05 NA NA NA hsa-miR-320b CACNA1C 1.23473838180754 3.04337566045537e-14 0.719670378607149 0.000375621162906313 miRNATAP -0.172256516211967 0.0011840565115244 NA NA NA hsa-miR-338-3p CACNA1C -0.948755228846395 8.99167125682392e-08 0.719670378607149 0.000375621162906313 miRanda -0.222963088474443 5.47772492355434e-06 NA NA NA hsa-miR-33a-5p CACNA1C 1.12988965056352 3.35742517382153e-07 0.719670378607149 0.000375621162906313 MirTarget -0.252442028990467 8.62728301494135e-11 NA NA NA hsa-miR-33b-5p CACNA1C 0.681845193600723 0.00407790722487864 0.719670378607149 0.000375621162906313 MirTarget -0.214977565061889 1.4064332260262e-08 NA NA NA hsa-miR-342-3p CACNA1C 0.99756868977753 9.28499866272332e-10 0.719670378607149 0.000375621162906313 MirTarget;PITA;miRanda;miRNATAP -0.199667194710218 0.000184690322027061 NA NA NA hsa-miR-34a-5p CACNA1C -0.117372471043915 0.364001947180738 0.719670378607149 0.000375621162906313 MirTarget -0.281543990553634 4.05016803806942e-05 NA NA NA hsa-miR-361-3p CACNA1C 0.272298288982435 0.0147874880476998 0.719670378607149 0.000375621162906313 MirTarget -0.317747840556767 6.33557736969175e-05 NA NA NA hsa-miR-378a-5p CACNA1C -1.31095692407946 2.375328908085e-15 0.719670378607149 0.000375621162906313 MirTarget -0.308974516496181 1.84457785572863e-09 NA NA NA hsa-miR-429 CACNA1C 0.559451508722375 0.00563641638673083 0.719670378607149 0.000375621162906313 MirTarget;PITA;miRanda;miRNATAP -0.323116457351393 3.90292925790269e-14 NA NA NA hsa-miR-484 CACNA1C 0.918280909791707 1.39168306854263e-14 0.719670378607149 0.000375621162906313 PITA;miRNATAP -0.202635310282624 0.00531926096091697 NA NA NA hsa-miR-582-5p CACNA1C -0.0366995972742474 0.821827119138923 0.719670378607149 0.000375621162906313 PITA -0.321854099613993 2.1956067360973e-09 NA NA NA hsa-miR-589-3p CACNA1C 1.59559692667315 6.2886410639161e-15 0.719670378607149 0.000375621162906313 MirTarget;mirMAP -0.220689918937969 3.9626103128824e-07 NA NA NA hsa-miR-660-5p CACNA1C -0.202705992887645 0.101093376073573 0.719670378607149 0.000375621162906313 MirTarget -0.302147802770609 2.50302580395863e-05 NA NA NA hsa-miR-7-1-3p CACNA1C 1.13646121619622 1.49823237535933e-14 0.719670378607149 0.000375621162906313 MirTarget -0.391459953360243 9.4007512525519e-12 NA NA NA hsa-miR-93-3p CACNA1C 1.69225547123293 1.50964095575087e-25 0.719670378607149 0.000375621162906313 mirMAP -0.181875013391164 0.000469738774067375 NA NA NA hsa-miR-944 CACNA1C 1.47323925060177 2.61626403984929e-13 0.719670378607149 0.000375621162906313 mirMAP -0.171308426503231 6.17237647485807e-05 NA NA NA hsa-miR-96-5p CACNA1C 1.42326703011157 4.39736150032373e-14 0.719670378607149 0.000375621162906313 MirTarget;TargetScan -0.274412676192001 1.25521291351877e-09 NA NA NA hsa-miR-135b-5p CACNA1D 1.5570143078477 4.60753610971455e-13 -1.95639038936177 2.57110355457836e-11 MirTarget -0.22036623029135 0.000188422557958207 NA NA NA hsa-miR-330-5p CACNA1D 0.944693925383906 5.04972895657346e-13 -1.95639038936177 2.57110355457836e-11 miRanda -0.415599942933241 1.96294214941745e-05 NA NA NA hsa-miR-542-3p CACNA1D 0.643308814904977 8.81635403230104e-07 -1.95639038936177 2.57110355457836e-11 miRanda -0.28335773465289 0.00423409612103097 NA NA NA hsa-miR-203a-3p CACNA1E 0.0441399794719697 0.880456392176704 0.396070889177026 0.149698528736606 MirTarget -0.169460048318237 3.01488508431146e-05 NA NA NA hsa-miR-205-5p CACNA1E 1.50759485376634 2.0003886738248e-16 0.396070889177026 0.149698528736606 mirMAP -0.243166073857012 0.000119166365536208 NA NA NA hsa-miR-2355-5p CACNA1E 1.47205546931107 8.65192179636668e-19 0.396070889177026 0.149698528736606 MirTarget;miRNATAP -0.186874105914569 0.00728043534500553 NA NA NA hsa-miR-31-5p CACNA1E 2.79079137807505 1.72181058015659e-13 0.396070889177026 0.149698528736606 mirMAP -0.126149999667106 4.87774630295219e-05 NA NA NA hsa-miR-452-5p CACNA1E 0.373288744398455 0.0348485937209964 0.396070889177026 0.149698528736606 mirMAP -0.211890054841859 0.00173909496176258 NA NA NA hsa-miR-942-5p CACNA1E 0.678652135586536 2.58063518495056e-07 0.396070889177026 0.149698528736606 MirTarget -0.288482038284397 0.00138118409289659 NA NA NA hsa-miR-28-3p CACNA1G 0.459875450032895 3.47095927872566e-07 -0.187888865627363 0.448347005237004 MirTarget;PITA;miRNATAP -0.392490407051012 0.00102874003728656 NA NA NA hsa-miR-362-5p CACNA1G 0.41089772861323 0.0404254902071382 -0.187888865627363 0.448347005237004 miRNATAP -0.206619802120444 0.000115713546112295 NA NA NA hsa-miR-590-3p CACNA1G 0.221436901462551 0.0965904764063157 -0.187888865627363 0.448347005237004 miRanda -0.405989309883074 4.75261157666913e-07 NA NA NA hsa-miR-590-5p CACNA1G 0.763025362395968 3.65305892505623e-09 -0.187888865627363 0.448347005237004 miRanda -0.532364979859755 5.37708603522659e-11 NA NA NA hsa-miR-629-3p CACNA1G 1.43262037314105 2.37092217984413e-19 -0.187888865627363 0.448347005237004 MirTarget -0.199485282265046 0.00229697113340555 NA NA NA hsa-miR-96-5p CACNA1G 1.42326703011157 4.39736150032373e-14 -0.187888865627363 0.448347005237004 TargetScan -0.185496276115186 0.000870362168296845 NA NA NA hsa-miR-32-5p CACNA1H -0.317310201890053 0.0102525324475293 0.924883396260454 2.33919562031352e-05 miRNATAP -0.230634167749787 0.00306294825988506 NA NA NA hsa-miR-361-3p CACNA1H 0.272298288982435 0.0147874880476998 0.924883396260454 2.33919562031352e-05 MirTarget;mirMAP -0.349152276622908 4.95576017135063e-05 NA NA NA hsa-miR-92a-3p CACNA1H 0.994679542307232 1.32587679156217e-16 0.924883396260454 2.33919562031352e-05 miRNATAP -0.328540556322014 2.19881447471904e-05 NA NA NA hsa-miR-22-5p CACNA1I 0.706731861922839 3.44318705980007e-07 -0.393073835778259 0.191692389395473 mirMAP -0.368002270670345 8.36838955578898e-05 NA NA NA hsa-miR-222-5p CACNA1I -0.100210968274912 0.597652996754512 -0.393073835778259 0.191692389395473 mirMAP -0.292105079963885 2.21377570821373e-05 NA NA NA hsa-miR-2355-5p CACNA1I 1.47205546931107 8.65192179636668e-19 -0.393073835778259 0.191692389395473 MirTarget -0.387882684662092 2.83386553553021e-07 NA NA NA hsa-miR-138-5p CACNA1S 0.702468796115049 0.0082478986123581 -3.12754160837629 3.20648625494297e-06 MirTarget -0.488018329509392 3.26224183145225e-05 NA NA NA hsa-miR-423-5p CACNA1S 0.60141781325829 1.62940950644999e-07 -3.12754160837629 3.20648625494297e-06 MirTarget -0.875789863489524 0.000607703164060762 NA NA NA hsa-let-7a-3p CACNA2D1 0.0966652362351867 0.423761916840503 -1.54368523099861 0.00017186367663955 mirMAP -0.826046527184582 2.59277635136427e-08 NA NA NA hsa-miR-103a-3p CACNA2D1 0.556219385347418 1.55815736455067e-09 -1.54368523099861 0.00017186367663955 miRNATAP -0.708372634697737 0.00026421712241301 NA NA NA hsa-miR-141-3p CACNA2D1 0.730011517758706 0.000120338355004032 -1.54368523099861 0.00017186367663955 TargetScan -0.584070649250647 3.31058710423269e-10 NA NA NA hsa-miR-16-2-3p CACNA2D1 1.1567130855258 1.01867256952189e-14 -1.54368523099861 0.00017186367663955 mirMAP -0.583734675946641 5.52654777103049e-07 NA NA NA hsa-miR-181a-5p CACNA2D1 0.819060835827404 1.38616688310277e-13 -1.54368523099861 0.00017186367663955 mirMAP -0.479731916866264 0.00267193559177596 NA NA NA hsa-miR-181b-5p CACNA2D1 0.974255518824355 2.64876280203475e-16 -1.54368523099861 0.00017186367663955 mirMAP -0.745565654641559 3.5309777966605e-07 NA NA NA hsa-miR-182-5p CACNA2D1 1.15060905311096 6.25565852529946e-10 -1.54368523099861 0.00017186367663955 miRNATAP -0.424546431174718 7.31050754741838e-06 NA NA NA hsa-miR-200b-3p CACNA2D1 0.0717138787925347 0.682858087587209 -1.54368523099861 0.00017186367663955 TargetScan -0.271248983133819 0.00837341718041804 NA NA NA hsa-miR-21-3p CACNA2D1 1.25126438776674 2.4124216716282e-17 -1.54368523099861 0.00017186367663955 mirMAP -0.606789003312369 2.29061727681236e-07 NA NA NA hsa-miR-26b-5p CACNA2D1 -0.254478038884324 0.0285227763044636 -1.54368523099861 0.00017186367663955 mirMAP -0.593011870017444 0.000134665261506328 NA NA NA hsa-miR-338-3p CACNA2D1 -0.948755228846395 8.99167125682392e-08 -1.54368523099861 0.00017186367663955 miRanda -0.58499929346739 3.50164157038936e-09 NA NA NA hsa-miR-450b-5p CACNA2D1 1.25529820885833 1.18847120528666e-15 -1.54368523099861 0.00017186367663955 mirMAP -0.38009712049964 0.000659213453617534 NA NA NA hsa-miR-576-5p CACNA2D1 0.940432050128373 6.90227595663302e-12 -1.54368523099861 0.00017186367663955 mirMAP -1.1269188601817 1.57411048263392e-19 NA NA NA hsa-miR-590-3p CACNA2D1 0.221436901462551 0.0965904764063157 -1.54368523099861 0.00017186367663955 mirMAP -0.351290061263415 0.00966907708643448 NA NA NA hsa-miR-7-1-3p CACNA2D1 1.13646121619622 1.49823237535933e-14 -1.54368523099861 0.00017186367663955 mirMAP -0.523825905084215 9.46123891858358e-06 NA NA NA hsa-miR-944 CACNA2D1 1.47323925060177 2.61626403984929e-13 -1.54368523099861 0.00017186367663955 mirMAP -0.28814627491828 0.000945062203874566 NA NA NA hsa-miR-96-5p CACNA2D1 1.42326703011157 4.39736150032373e-14 -1.54368523099861 0.00017186367663955 TargetScan;miRNATAP -0.541853244678946 3.80555669491793e-09 NA NA NA hsa-miR-181b-5p CACNA2D2 0.974255518824355 2.64876280203475e-16 -1.3923459216616 1.63670422073682e-10 miRNATAP -0.289092077272338 0.000254745012613325 NA NA NA hsa-miR-193a-3p CACNA2D2 0.22120710726779 0.111827069464729 -1.3923459216616 1.63670422073682e-10 miRanda -0.301480315623725 1.38191716349437e-05 NA NA NA hsa-miR-205-5p CACNA2D2 1.50759485376634 2.0003886738248e-16 -1.3923459216616 1.63670422073682e-10 miRNATAP -0.415396088161785 6.15031697078702e-17 NA NA NA hsa-miR-22-5p CACNA2D2 0.706731861922839 3.44318705980007e-07 -1.3923459216616 1.63670422073682e-10 mirMAP -0.359887284219425 1.51457080289273e-07 NA NA NA hsa-miR-3614-5p CACNA2D2 0.955957969488529 2.95347675446694e-05 -1.3923459216616 1.63670422073682e-10 mirMAP -0.257961940509553 4.35722457831217e-10 NA NA NA hsa-miR-455-3p CACNA2D2 2.68574446868387 4.28975903022818e-42 -1.3923459216616 1.63670422073682e-10 PITA;miRNATAP -0.388663222312757 3.8672389928875e-19 NA NA NA hsa-miR-96-5p CACNA2D2 1.42326703011157 4.39736150032373e-14 -1.3923459216616 1.63670422073682e-10 MirTarget;TargetScan;miRNATAP -0.148239447402727 0.00300843145664146 NA NA NA hsa-miR-125a-3p CACNA2D3 0.116035800853173 0.444825559956959 -1.01088425094627 5.45351468160873e-05 miRanda -0.281810564070034 9.82713550903624e-05 NA NA NA hsa-miR-18a-3p CACNA2D3 1.82583720936229 7.51297960972179e-19 -1.01088425094627 5.45351468160873e-05 miRNAWalker2_validate -0.178089284389161 0.000746369649229354 NA NA NA hsa-miR-193a-3p CACNA2D3 0.22120710726779 0.111827069464729 -1.01088425094627 5.45351468160873e-05 miRanda -0.391671974592391 6.32499408268379e-07 NA NA NA hsa-miR-324-5p CACNA2D4 1.66709479707179 1.45961450445769e-23 -0.165475171969882 0.311789498249756 miRanda -0.121960409184157 0.00283271463835968 NA NA NA hsa-miR-429 CACNA2D4 0.559451508722375 0.00563641638673083 -0.165475171969882 0.311789498249756 miRanda -0.133459367286253 0.000139334917407417 NA NA NA hsa-miR-15b-5p CACNB1 0.85315666454713 3.79816274836297e-12 -1.1328681694474 1.83385385901281e-06 miRNATAP -0.268781197951087 0.0012972358047708 NA NA NA hsa-miR-320b CACNB1 1.23473838180754 3.04337566045537e-14 -1.1328681694474 1.83385385901281e-06 miRanda -0.19228304820629 0.00215846705802387 NA NA NA hsa-miR-331-3p CACNB1 0.906385914819361 4.27653809739414e-11 -1.1328681694474 1.83385385901281e-06 miRNATAP -0.29048079964761 9.77658003697373e-05 NA NA NA hsa-miR-429 CACNB1 0.559451508722375 0.00563641638673083 -1.1328681694474 1.83385385901281e-06 miRNATAP -0.27656988863233 6.03009462902346e-08 NA NA NA hsa-miR-576-5p CACNB1 0.940432050128373 6.90227595663302e-12 -1.1328681694474 1.83385385901281e-06 PITA;mirMAP -0.223382494908726 0.00284193007080285 NA NA NA hsa-miR-96-5p CACNB1 1.42326703011157 4.39736150032373e-14 -1.1328681694474 1.83385385901281e-06 TargetScan;miRNATAP -0.224676975024163 2.95017966480464e-05 NA NA NA hsa-let-7a-3p CACNB2 0.0966652362351867 0.423761916840503 -0.724019732770298 7.45304913827331e-05 MirTarget;mirMAP -0.196299276653564 0.00325856218602462 NA NA NA hsa-let-7f-1-3p CACNB2 0.700374242293247 8.65000484720084e-08 -0.724019732770298 7.45304913827331e-05 MirTarget;mirMAP -0.274253858495192 5.56016790065814e-06 NA NA NA hsa-miR-103a-2-5p CACNB2 1.37988337975616 6.74852943995612e-08 -0.724019732770298 7.45304913827331e-05 MirTarget -0.141943756943069 2.33411741243603e-05 NA NA NA hsa-miR-182-5p CACNB2 1.15060905311096 6.25565852529946e-10 -0.724019732770298 7.45304913827331e-05 miRNATAP -0.164778833098588 9.48472069637539e-05 NA NA NA hsa-miR-200c-5p CACNB2 0.904697667677842 1.36157973413856e-06 -0.724019732770298 7.45304913827331e-05 MirTarget;miRNATAP -0.2514261527589 1.82427689863497e-09 NA NA NA hsa-miR-23a-3p CACNB2 0.348231698801568 6.4911858506572e-05 -0.724019732770298 7.45304913827331e-05 mirMAP -0.436439696428077 2.06489947086201e-06 NA NA NA hsa-miR-27a-3p CACNB2 0.348456440505425 0.00126682892514312 -0.724019732770298 7.45304913827331e-05 MirTarget;miRNATAP -0.398310771498815 6.42370946125117e-08 NA NA NA hsa-miR-29a-5p CACNB2 0.323252792625584 0.0370417231222825 -0.724019732770298 7.45304913827331e-05 MirTarget -0.151924363353258 0.00332080056433389 NA NA NA hsa-miR-31-5p CACNB2 2.79079137807505 1.72181058015659e-13 -0.724019732770298 7.45304913827331e-05 MirTarget;miRNATAP -0.155920883972894 1.89840666005546e-14 NA NA NA hsa-miR-339-5p CACNB2 1.07771430326938 2.45772601859307e-09 -0.724019732770298 7.45304913827331e-05 miRNATAP -0.194227232012109 7.75848033619509e-06 NA NA NA hsa-miR-429 CACNB2 0.559451508722375 0.00563641638673083 -0.724019732770298 7.45304913827331e-05 PITA;miRanda;miRNATAP -0.149184187617659 0.000154494527088257 NA NA NA hsa-miR-550a-3p CACNB2 1.63595944765448 5.87048146042097e-24 -0.724019732770298 7.45304913827331e-05 MirTarget;miRNATAP -0.222822265883456 3.02244998429631e-06 NA NA NA hsa-miR-7-1-3p CACNB2 1.13646121619622 1.49823237535933e-14 -0.724019732770298 7.45304913827331e-05 mirMAP -0.238061444308659 5.99466172937325e-06 NA NA NA hsa-miR-96-5p CACNB2 1.42326703011157 4.39736150032373e-14 -0.724019732770298 7.45304913827331e-05 miRNATAP -0.215380400713149 1.54655662099898e-07 NA NA NA hsa-miR-361-3p CACNB3 0.272298288982435 0.0147874880476998 0.00802960214726678 0.938342246284262 mirMAP -0.122510571084831 0.00252280133218529 NA NA NA hsa-miR-146b-5p CACNB4 0.917975986853978 3.33749259316025e-09 -3.54491535291983 6.36788976029661e-29 miRanda -0.368619515466989 7.18355298827755e-05 NA NA NA hsa-miR-15a-5p CACNB4 0.783550182002274 2.60699595655907e-11 -3.54491535291983 6.36788976029661e-29 miRNATAP -0.405109698098423 0.00097417732615068 NA NA NA hsa-miR-181a-5p CACNB4 0.819060835827404 1.38616688310277e-13 -3.54491535291983 6.36788976029661e-29 mirMAP -0.400141550642712 0.00208190593398206 NA NA NA hsa-miR-181b-5p CACNB4 0.974255518824355 2.64876280203475e-16 -3.54491535291983 6.36788976029661e-29 mirMAP -0.754003839377826 1.86598879976802e-10 NA NA NA hsa-miR-196a-5p CACNB4 4.37328069546676 8.16720434501581e-34 -3.54491535291983 6.36788976029661e-29 miRNATAP -0.267381607164912 6.30961342887926e-13 NA NA NA hsa-miR-196b-5p CACNB4 3.78958266598891 1.12771732893771e-44 -3.54491535291983 6.36788976029661e-29 miRNATAP -0.240902957508414 9.55419799547098e-07 NA NA NA hsa-miR-205-3p CACNB4 1.2960640797621 5.80786479909147e-11 -3.54491535291983 6.36788976029661e-29 mirMAP -0.285302907013881 8.14644810502297e-05 NA NA NA hsa-miR-20a-3p CACNB4 1.34885093664027 2.07697464119202e-12 -3.54491535291983 6.36788976029661e-29 miRNATAP -0.272134451208705 0.00026177287182927 NA NA NA hsa-miR-221-3p CACNB4 0.410625614724387 0.000741090075261272 -3.54491535291983 6.36788976029661e-29 miRNATAP -0.570761516957985 1.87820517720162e-06 NA NA NA hsa-miR-222-3p CACNB4 1.08197052578759 2.32604040301699e-14 -3.54491535291983 6.36788976029661e-29 miRNATAP -0.725937143701577 2.05749079736631e-13 NA NA NA hsa-miR-29b-1-5p CACNB4 1.39669186711325 4.36960953138935e-11 -3.54491535291983 6.36788976029661e-29 mirMAP -0.462164763138419 4.18451866775743e-12 NA NA NA hsa-miR-421 CACNB4 0.945488088619653 2.35762398527362e-09 -3.54491535291983 6.36788976029661e-29 PITA;miRanda;miRNATAP -0.321296749949962 0.000438863070352166 NA NA NA hsa-miR-424-5p CACNB4 1.48125289532143 9.10372985713165e-19 -3.54491535291983 6.36788976029661e-29 miRNATAP -0.619030330348655 7.02573925852616e-14 NA NA NA hsa-miR-450b-5p CACNB4 1.25529820885833 1.18847120528666e-15 -3.54491535291983 6.36788976029661e-29 miRNATAP -0.508326553136288 1.59589812602146e-08 NA NA NA hsa-miR-455-5p CACNB4 1.408595672323 5.52039116456697e-22 -3.54491535291983 6.36788976029661e-29 PITA;miRanda;miRNATAP -0.972340927874085 3.14470205285285e-26 NA NA NA hsa-miR-542-3p CACNB4 0.643308814904977 8.81635403230104e-07 -3.54491535291983 6.36788976029661e-29 miRanda -0.499434449062351 6.43505918048019e-06 NA NA NA hsa-miR-550a-3p CACNB4 1.63595944765448 5.87048146042097e-24 -3.54491535291983 6.36788976029661e-29 miRNATAP -0.573816553734445 3.08888065549121e-11 NA NA NA hsa-miR-589-3p CACNB4 1.59559692667315 6.2886410639161e-15 -3.54491535291983 6.36788976029661e-29 mirMAP -0.334462124743405 3.5710996775141e-06 NA NA NA hsa-miR-92a-3p CACNB4 0.994679542307232 1.32587679156217e-16 -3.54491535291983 6.36788976029661e-29 mirMAP -0.352522752066331 0.0029940189267833 NA NA NA hsa-miR-944 CACNB4 1.47323925060177 2.61626403984929e-13 -3.54491535291983 6.36788976029661e-29 PITA;mirMAP -0.490689882403291 1.83895599320653e-12 NA NA NA hsa-miR-590-5p CACNG1 0.763025362395968 3.65305892505623e-09 -2.1385940133294 0.000296678501503111 miRanda -0.597239926940883 0.00255279486376012 NA NA NA hsa-miR-186-5p CACNG4 0.353452958261612 0.000145058448579496 -0.0214055245945487 0.959865085967095 mirMAP -0.532556883394814 0.00786748606553903 NA NA NA hsa-miR-29b-3p CACNG4 -0.110721443686039 0.511264554091106 -0.0214055245945487 0.959865085967095 miRNATAP -0.321338812666019 0.00351883721652981 NA NA NA hsa-miR-425-3p CACNG4 -0.131758691803062 0.298544127488224 -0.0214055245945487 0.959865085967095 mirMAP -0.493353057127014 0.000781637326118771 NA NA NA hsa-miR-582-3p CACNG4 -0.248056267546012 0.143798829508405 -0.0214055245945487 0.959865085967095 miRNATAP -0.301977051854584 0.00574101840065222 NA NA NA hsa-miR-330-5p CACNG6 0.944693925383906 5.04972895657346e-13 -2.93914584829723 5.4932745451534e-09 miRanda -0.556579500317371 0.000862449664823185 NA NA NA hsa-let-7a-5p CDC25B -0.439381775414001 3.1119785480023e-05 1.62195703561335 8.32279262690367e-29 miRNAWalker2_validate -0.199816860480063 0.00169742354140644 NA NA NA hsa-miR-148a-3p CDC25B -0.428944290834563 0.00954246923521465 1.62195703561335 8.32279262690367e-29 miRNAWalker2_validate;miRNATAP -0.207437187419087 2.44696616447647e-07 25341915 Gene CDC25B might be the target gene of miR-148a according to the results of targetscan; CDC25B may be the target gene of miR-148a that plays a role in tumor suppressor gastric cancer hsa-miR-27b-3p CDC25B -0.732682718863563 2.26896143573324e-09 1.62195703561335 8.32279262690367e-29 miRNATAP -0.225524824628289 2.91259262252813e-05 NA NA NA hsa-miR-106b-5p CDC42 0.50378717276868 1.45412404526866e-05 0.0129593551240648 0.846406884079324 miRNAWalker2_validate -0.131295640190421 9.81003904528409e-08 NA NA NA hsa-miR-107 CDC42 -0.0447040564279497 0.671618791096755 0.0129593551240648 0.846406884079324 miRanda -0.130309156837011 2.19468768424638e-06 23627613 Quantitative real-time PCR was used to analyze the expression of miR-107 and its bioinformatically identified targets PIM-1 and CDC42 esophageal cancer hsa-miR-28-3p CDC42 0.459875450032895 3.47095927872566e-07 0.0129593551240648 0.846406884079324 PITA -0.127737879674437 6.54245576973787e-05 NA NA NA hsa-let-7a-3p CRK 0.0966652362351867 0.423761916840503 -0.0814815970417762 0.345915316348875 MirTarget;miRNATAP -0.108875579233768 0.000481006610863016 NA NA NA hsa-miR-125a-5p CRK 0.215366061934933 0.119550904549401 -0.0814815970417762 0.345915316348875 miRNAWalker2_validate -0.211280598305849 1.57695895753221e-15 NA NA NA hsa-miR-126-3p CRK 0.0487843863772834 0.730130847436008 -0.0814815970417762 0.345915316348875 miRNAWalker2_validate;miRTarBase;miRNATAP -0.153162466455067 5.8966375713083e-09 21702040;22845403;25027343;18602365;20619534 The overexpression of mir-34b and mir-126 decreased the expression of c-Met and Crk respectively;miR-126 is also known to target other crucial oncogenes in PDAC such as KRAS and CRK;MiR 126 inhibits the invasion of gastric cancer cell in part by targeting Crk; Moreover overexpression of miR-126 significantly decreased p < 0.05 the protein levels of Crk which has previously been identified as a direct target of miR-126; Our results demonstrated that overexpression of miR-126 inhibited GC cells invasion in part by targeting Crk;Crk is a predicted putative target gene for miR-126; Over-expression of miR126 in a lung cancer cell line resulted in a decrease in Crk protein without any alteration in the associated mRNA; MiR-126 alters lung cancer cell phenotype by inhibiting adhesion migration and invasion and the effects on invasion may be partially mediated through Crk regulation;Mechanistically we identified the adaptor protein Crk as a target of miR-126; Taken together our results suggest that miR-126 may function as a tumour suppressor in gastric cancer with Crk as a direct target ;;;; lung squamous cell cancer;pancreatic cancer;gastric cancer;lung squamous cell cancer;gastric cancer hsa-miR-142-3p CRK 1.12754191614028 1.68798138028946e-08 -0.0814815970417762 0.345915316348875 PITA;miRanda;miRNATAP -0.115662663148418 2.22593681714229e-10 NA NA NA hsa-miR-146a-5p CRK -0.0201236699646614 0.905882759106561 -0.0814815970417762 0.345915316348875 MirTarget -0.127781751149833 4.74365094113634e-09 NA NA NA hsa-miR-146b-5p CRK 0.917975986853978 3.33749259316025e-09 -0.0814815970417762 0.345915316348875 MirTarget -0.119053097010402 4.82607518489724e-07 NA NA NA hsa-miR-186-5p CRK 0.353452958261612 0.000145058448579496 -0.0814815970417762 0.345915316348875 miRNATAP -0.227935632822043 1.31813619305264e-08 NA NA NA hsa-miR-20a-5p CRK 1.1531986665452 1.02385132917958e-11 -0.0814815970417762 0.345915316348875 MirTarget;miRNATAP -0.126073710865343 4.03996487988588e-09 NA NA NA hsa-miR-20b-5p CRK 0.345967670847176 0.232014828043601 -0.0814815970417762 0.345915316348875 MirTarget;miRNATAP -0.105940717175617 3.69142183917491e-17 NA NA NA hsa-miR-30a-5p CRK -1.79779915425811 1.93360169837799e-26 -0.0814815970417762 0.345915316348875 miRNATAP -0.114904019363501 3.76048741711619e-08 NA NA NA hsa-miR-30c-5p CRK 0.021222006155897 0.886366656528128 -0.0814815970417762 0.345915316348875 miRNATAP -0.233690942434138 9.04449412602839e-22 NA NA NA hsa-miR-320a CRK 0.801356001806321 4.91397101474502e-09 -0.0814815970417762 0.345915316348875 miRNATAP -0.129728228408606 1.38962738572384e-06 NA NA NA hsa-miR-362-3p CRK -0.697212068252854 2.61718493418184e-06 -0.0814815970417762 0.345915316348875 miRanda -0.160817070995251 9.12248972439057e-11 NA NA NA hsa-miR-374a-5p CRK -0.621903385111545 6.61791773205282e-12 -0.0814815970417762 0.345915316348875 mirMAP -0.127601156764261 0.00186318077118061 NA NA NA hsa-miR-374b-5p CRK -0.288413933608091 0.0041474558664058 -0.0814815970417762 0.345915316348875 mirMAP -0.291252214036466 1.6689365207603e-15 NA NA NA hsa-miR-590-3p CRK 0.221436901462551 0.0965904764063157 -0.0814815970417762 0.345915316348875 mirMAP -0.124469824258207 9.48800746302805e-06 NA NA NA hsa-miR-93-5p CRK 1.61042951896619 5.1280369606967e-24 -0.0814815970417762 0.345915316348875 MirTarget;miRNATAP -0.138240646889777 4.59606999186152e-10 NA NA NA hsa-miR-140-5p CRKL -0.412389003031485 0.000136051708543369 0.528918151929006 5.6460064779249e-08 MirTarget;miRanda -0.148286846296565 0.000184095130885934 NA NA NA hsa-miR-15a-5p CRKL 0.783550182002274 2.60699595655907e-11 0.528918151929006 5.6460064779249e-08 miRTarBase;MirTarget;miRNATAP -0.144538033530944 5.53643177410427e-05 NA NA NA hsa-miR-181c-5p CRKL -0.168991199007857 0.196949106150297 0.528918151929006 5.6460064779249e-08 mirMAP -0.126526013991964 0.000114352461152686 NA NA NA hsa-miR-29a-3p CRKL -1.26881270980079 2.82496991513463e-22 0.528918151929006 5.6460064779249e-08 miRNAWalker2_validate -0.107501254237066 0.00064337575741096 NA NA NA hsa-miR-29a-5p CRKL 0.323252792625584 0.0370417231222825 0.528918151929006 5.6460064779249e-08 MirTarget -0.115690685174499 2.72902866724171e-05 NA NA NA hsa-miR-30a-5p CRKL -1.79779915425811 1.93360169837799e-26 0.528918151929006 5.6460064779249e-08 MirTarget;mirMAP;miRNATAP -0.194237239802538 1.19884840461708e-16 NA NA NA hsa-miR-30b-5p CRKL -0.400238605368173 0.00346540992719245 0.528918151929006 5.6460064779249e-08 MirTarget;mirMAP -0.171450781185709 3.24023569898963e-08 NA NA NA hsa-miR-30c-5p CRKL 0.021222006155897 0.886366656528128 0.528918151929006 5.6460064779249e-08 MirTarget;mirMAP;miRNATAP -0.164563387390684 9.25291288122559e-09 NA NA NA hsa-miR-30d-5p CRKL -0.38399848121878 0.000171129616944749 0.528918151929006 5.6460064779249e-08 MirTarget;mirMAP;miRNATAP -0.16588953991778 7.7513235830595e-05 NA NA NA hsa-miR-30e-5p CRKL -1.02114836019762 6.81961221797866e-17 0.528918151929006 5.6460064779249e-08 MirTarget;mirMAP -0.174965236001469 2.35549918395175e-07 NA NA NA hsa-miR-320a CRKL 0.801356001806321 4.91397101474502e-09 0.528918151929006 5.6460064779249e-08 MirTarget;miRanda;miRNATAP -0.111656485690013 0.000299381746100226 NA NA NA hsa-miR-497-5p CRKL -0.966244470847844 5.26505649147857e-12 0.528918151929006 5.6460064779249e-08 MirTarget;miRNATAP -0.12106305811323 5.30486111800867e-05 NA NA NA hsa-let-7i-5p DUSP1 0.249440992451337 0.00426823922424972 -1.63248446721276 2.08825586652006e-15 miRNATAP -0.352219895038081 0.000962679160662121 NA NA NA hsa-miR-200c-3p DUSP1 0.630251054099546 0.000131975031451555 -1.63248446721276 2.08825586652006e-15 MirTarget;miRNATAP -0.171674206318347 0.00204202551827774 NA NA NA hsa-miR-324-3p DUSP1 0.867391246413545 3.63808540490361e-10 -1.63248446721276 2.08825586652006e-15 MirTarget -0.401267902900462 5.87710746938537e-10 NA NA NA hsa-miR-331-5p DUSP1 0.851618030062133 1.42670149420057e-14 -1.63248446721276 2.08825586652006e-15 PITA;miRNATAP -0.405626952888443 5.56210693131416e-07 NA NA NA hsa-miR-425-3p DUSP1 -0.131758691803062 0.298544127488224 -1.63248446721276 2.08825586652006e-15 MirTarget -0.192236112185177 0.00871568133290049 NA NA NA hsa-miR-429 DUSP1 0.559451508722375 0.00563641638673083 -1.63248446721276 2.08825586652006e-15 MirTarget;PITA;miRanda;miRNATAP -0.14239171766777 0.00174429341760274 NA NA NA hsa-miR-25-3p DUSP10 0.76549796417801 3.32282098247097e-11 0.458398614306813 0.00486910665107833 MirTarget;miRNATAP -0.199428806169828 0.00101573920568236 NA NA NA hsa-miR-361-5p DUSP10 0.0803683277369505 0.314043140368058 0.458398614306813 0.00486910665107833 miRanda -0.284652165784694 0.00167839651810921 NA NA NA hsa-miR-363-3p DUSP10 -0.608157508016978 0.0186109501272176 0.458398614306813 0.00486910665107833 MirTarget -0.100378587637513 0.000244082093971446 NA NA NA hsa-miR-92a-3p DUSP10 0.994679542307232 1.32587679156217e-16 0.458398614306813 0.00486910665107833 MirTarget;miRNATAP -0.198133793260213 0.000570805353041114 24332650 DUSP10 is responsible for miR-92a induced JNK signalling and cell proliferation pancreatic cancer hsa-miR-942-5p DUSP10 0.678652135586536 2.58063518495056e-07 0.458398614306813 0.00486910665107833 MirTarget -0.15272961120808 0.00436045745929873 NA NA NA hsa-miR-107 DUSP14 -0.0447040564279497 0.671618791096755 0.852593807317095 5.37712311852287e-09 miRanda -0.319518427815356 1.83965704597673e-07 NA NA NA hsa-miR-16-5p DUSP14 0.521122945828175 1.40561786410572e-06 0.852593807317095 5.37712311852287e-09 miRNAWalker2_validate -0.163780033894596 0.00605885621523591 NA NA NA hsa-miR-320a DUSP14 0.801356001806321 4.91397101474502e-09 0.852593807317095 5.37712311852287e-09 miRanda -0.124745068168473 0.00746641019044575 NA NA NA hsa-miR-628-5p DUSP14 -0.554239048796013 4.92386883216087e-05 0.852593807317095 5.37712311852287e-09 PITA -0.35776786755137 7.40481113902381e-15 NA NA NA hsa-miR-103a-2-5p DUSP16 1.37988337975616 6.74852943995612e-08 -0.582828984633543 2.2907036890164e-08 mirMAP -0.106244425696984 2.82297342518594e-08 NA NA NA hsa-miR-342-3p DUSP16 0.99756868977753 9.28499866272332e-10 -0.582828984633543 2.2907036890164e-08 miRNATAP -0.129939234276133 2.51410108312943e-06 NA NA NA hsa-let-7a-5p DUSP22 -0.439381775414001 3.1119785480023e-05 -0.666617939511668 2.25527677018091e-11 TargetScan -0.145587922793569 0.000508251126900289 NA NA NA hsa-miR-28-5p DUSP22 -0.026996999089909 0.733047113251652 -0.666617939511668 2.25527677018091e-11 miRanda -0.410979383685817 1.55900037784705e-13 NA NA NA hsa-miR-320a DUSP22 0.801356001806321 4.91397101474502e-09 -0.666617939511668 2.25527677018091e-11 miRanda -0.104741252922871 0.00101165579359591 NA NA NA hsa-miR-320b DUSP22 1.23473838180754 3.04337566045537e-14 -0.666617939511668 2.25527677018091e-11 miRanda -0.174828522352486 2.03046586905386e-11 NA NA NA hsa-miR-96-5p DUSP22 1.42326703011157 4.39736150032373e-14 -0.666617939511668 2.25527677018091e-11 TargetScan -0.101086899047938 8.71886501761739e-06 NA NA NA hsa-miR-130b-5p DUSP3 1.77265255049999 1.43627774829684e-29 -0.614736723154215 9.54841698364256e-16 MirTarget -0.191023180843735 4.46213088704378e-22 NA NA NA hsa-miR-141-3p DUSP3 0.730011517758706 0.000120338355004032 -0.614736723154215 9.54841698364256e-16 MirTarget;TargetScan;miRNATAP -0.176084011176474 7.67224883557249e-25 NA NA NA hsa-miR-15a-5p DUSP3 0.783550182002274 2.60699595655907e-11 -0.614736723154215 9.54841698364256e-16 MirTarget;miRNATAP -0.219529838138824 4.26858903873599e-15 NA NA NA hsa-miR-15b-5p DUSP3 0.85315666454713 3.79816274836297e-12 -0.614736723154215 9.54841698364256e-16 MirTarget;miRNATAP -0.191363016589537 9.85101566828301e-13 NA NA NA hsa-miR-16-5p DUSP3 0.521122945828175 1.40561786410572e-06 -0.614736723154215 9.54841698364256e-16 MirTarget;miRNATAP -0.205827995531794 3.41363902430095e-11 NA NA NA hsa-miR-182-5p DUSP3 1.15060905311096 6.25565852529946e-10 -0.614736723154215 9.54841698364256e-16 mirMAP -0.13579291345422 1.41202306214549e-14 NA NA NA hsa-miR-186-5p DUSP3 0.353452958261612 0.000145058448579496 -0.614736723154215 9.54841698364256e-16 mirMAP -0.18533596177146 4.33728287702414e-07 NA NA NA hsa-miR-197-3p DUSP3 0.878693269130833 3.84847526014135e-15 -0.614736723154215 9.54841698364256e-16 mirMAP -0.106534929695529 0.000363355616630944 NA NA NA hsa-miR-200a-3p DUSP3 0.607140814457753 0.00289840524858752 -0.614736723154215 9.54841698364256e-16 MirTarget;miRNATAP -0.179467952999569 6.76562469073908e-30 NA NA NA hsa-miR-221-3p DUSP3 0.410625614724387 0.000741090075261272 -0.614736723154215 9.54841698364256e-16 mirMAP -0.152341261556201 4.45823340004257e-08 NA NA NA hsa-miR-320a DUSP3 0.801356001806321 4.91397101474502e-09 -0.614736723154215 9.54841698364256e-16 mirMAP -0.161285697718045 2.96502717084665e-11 NA NA NA hsa-miR-320b DUSP3 1.23473838180754 3.04337566045537e-14 -0.614736723154215 9.54841698364256e-16 mirMAP -0.161884257548218 5.35195527534855e-16 NA NA NA hsa-miR-361-5p DUSP3 0.0803683277369505 0.314043140368058 -0.614736723154215 9.54841698364256e-16 miRNAWalker2_validate;miRanda -0.141060850091632 0.0012050733541246 NA NA NA hsa-miR-3913-5p DUSP3 0.48532077857571 0.00112373589405304 -0.614736723154215 9.54841698364256e-16 MirTarget -0.135609641839694 2.39292539502085e-09 NA NA NA hsa-miR-429 DUSP3 0.559451508722375 0.00563641638673083 -0.614736723154215 9.54841698364256e-16 miRNATAP -0.163676241618777 3.68680225627278e-24 NA NA NA hsa-miR-484 DUSP3 0.918280909791707 1.39168306854263e-14 -0.614736723154215 9.54841698364256e-16 mirMAP -0.173805062891689 3.23992433420343e-10 NA NA NA hsa-miR-589-3p DUSP3 1.59559692667315 6.2886410639161e-15 -0.614736723154215 9.54841698364256e-16 mirMAP -0.111510496870187 2.11697625776981e-11 NA NA NA hsa-miR-590-3p DUSP3 0.221436901462551 0.0965904764063157 -0.614736723154215 9.54841698364256e-16 MirTarget;miRanda;mirMAP -0.115864260660101 6.06492754378767e-06 NA NA NA hsa-miR-708-5p DUSP3 1.54207894190626 2.2887257992285e-19 -0.614736723154215 9.54841698364256e-16 mirMAP -0.128550976502024 1.05255895892888e-11 NA NA NA hsa-miR-141-5p DUSP4 0.623874471326586 0.0018690552472983 -0.561851288273301 0.00782378661650914 mirMAP -0.181616084699972 6.97234773077747e-05 NA NA NA hsa-miR-199a-5p DUSP4 -0.364835768178638 0.0435119211101981 -0.561851288273301 0.00782378661650914 miRanda -0.184853086629782 0.000283095105782761 NA NA NA hsa-miR-199b-5p DUSP4 -1.08432682485992 7.68241801134089e-10 -0.561851288273301 0.00782378661650914 miRanda -0.203688810547392 7.22193170727305e-05 NA NA NA hsa-miR-200b-3p DUSP4 0.0717138787925347 0.682858087587209 -0.561851288273301 0.00782378661650914 mirMAP -0.265518407692552 3.68609859951746e-07 NA NA NA hsa-miR-200c-3p DUSP4 0.630251054099546 0.000131975031451555 -0.561851288273301 0.00782378661650914 mirMAP -0.202927932528026 0.00026087088589744 NA NA NA hsa-miR-205-5p DUSP4 1.50759485376634 2.0003886738248e-16 -0.561851288273301 0.00782378661650914 mirMAP -0.283233934637781 4.21936880327713e-09 NA NA NA hsa-miR-23b-3p DUSP4 -0.497563803223134 3.31483353357535e-05 -0.561851288273301 0.00782378661650914 mirMAP -0.376204953466775 8.09227291258591e-07 NA NA NA hsa-miR-429 DUSP4 0.559451508722375 0.00563641638673083 -0.561851288273301 0.00782378661650914 miRanda;mirMAP -0.234567720950052 2.00838762797464e-07 NA NA NA hsa-miR-944 DUSP4 1.47323925060177 2.61626403984929e-13 -0.561851288273301 0.00782378661650914 mirMAP -0.169092736623207 0.000148007828531795 NA NA NA hsa-miR-324-5p DUSP5 1.66709479707179 1.45961450445769e-23 -1.29145980873426 2.77404644342612e-13 miRanda -0.161837586277211 0.000340884206965013 NA NA NA hsa-miR-331-3p DUSP5 0.906385914819361 4.27653809739414e-11 -1.29145980873426 2.77404644342612e-13 MirTarget;miRNATAP -0.151204955772763 0.00745935729945446 NA NA NA hsa-miR-450b-5p DUSP5 1.25529820885833 1.18847120528666e-15 -1.29145980873426 2.77404644342612e-13 miRNATAP -0.158216824899006 0.00121665281212156 NA NA NA hsa-miR-335-5p DUSP6 -1.17227779671552 1.49282618530733e-10 0.565431959404813 0.00233279651584595 miRNAWalker2_validate -0.205535817757446 2.04969401037074e-06 NA NA NA hsa-miR-361-5p DUSP6 0.0803683277369505 0.314043140368058 0.565431959404813 0.00233279651584595 PITA;miRanda -0.471396823229582 4.62840378277235e-06 NA NA NA hsa-miR-374a-5p DUSP6 -0.621903385111545 6.61791773205282e-12 0.565431959404813 0.00233279651584595 mirMAP -0.325156535920217 0.00024200393162647 NA NA NA hsa-let-7c-5p DUSP7 -2.07953368242668 3.46048888391218e-23 0.492217510050578 0.000331174099301001 miRNAWalker2_validate -0.185708782706109 4.49963819162256e-12 NA NA NA hsa-miR-107 DUSP7 -0.0447040564279497 0.671618791096755 0.492217510050578 0.000331174099301001 miRanda -0.202018940928468 0.000424052455318197 NA NA NA hsa-miR-10a-5p DUSP7 -0.316491613573591 0.148093857656453 0.492217510050578 0.000331174099301001 mirMAP -0.140711849622344 2.21153012200279e-07 NA NA NA hsa-miR-125a-5p DUSP7 0.215366061934933 0.119550904549401 0.492217510050578 0.000331174099301001 miRanda -0.141770170760342 0.0011066764102689 NA NA NA hsa-miR-29c-3p DUSP7 -2.08166260448948 8.3238369390898e-24 0.492217510050578 0.000331174099301001 mirMAP -0.158804313257935 6.28596706502607e-09 NA NA NA hsa-miR-335-5p DUSP7 -1.17227779671552 1.49282618530733e-10 0.492217510050578 0.000331174099301001 mirMAP -0.227384793290856 5.66907414266766e-13 NA NA NA hsa-miR-345-5p DUSP7 0.882162580294938 2.95895678052434e-07 0.492217510050578 0.000331174099301001 mirMAP -0.134674677841933 8.98477085644875e-05 NA NA NA hsa-miR-362-5p DUSP7 0.41089772861323 0.0404254902071382 0.492217510050578 0.000331174099301001 mirMAP -0.102052506408177 0.000627395323928262 NA NA NA hsa-miR-625-5p DUSP7 0.346770617079364 0.02860843739549 0.492217510050578 0.000331174099301001 mirMAP -0.182749668504355 1.38681049859332e-06 NA NA NA hsa-miR-1976 DUSP8 0.638808083289405 2.94840228896364e-07 -0.031948503406436 0.847814646225782 MirTarget -0.155750409436262 0.0070274510045905 NA NA NA hsa-miR-21-5p DUSP8 1.62465922021121 3.44191300985109e-58 -0.031948503406436 0.847814646225782 miRNAWalker2_validate;MirTarget -0.21434655035599 0.00083452385054582 NA NA NA hsa-miR-342-5p DUSP8 0.862385578881784 1.60007936373305e-08 -0.031948503406436 0.847814646225782 mirMAP -0.164866747548058 0.000427524571992011 NA NA NA hsa-let-7b-5p DUSP9 -0.2489842756826 0.0211384499461719 2.74743344854898 1.46260662722122e-19 miRNATAP -0.418176459533938 0.00107747652951821 NA NA NA hsa-miR-100-5p DUSP9 -1.85857794619369 1.248973638996e-25 2.74743344854898 1.46260662722122e-19 mirMAP -0.28981578647839 7.82938351451513e-05 NA NA NA hsa-miR-30a-3p DUSP9 -2.26144364746452 8.12421214153823e-31 2.74743344854898 1.46260662722122e-19 MirTarget -0.323628155179024 7.69649989047074e-07 NA NA NA hsa-miR-30e-3p DUSP9 -0.890635378639789 1.65740480611339e-16 2.74743344854898 1.46260662722122e-19 MirTarget -0.346789777726442 0.0052573075207699 NA NA NA hsa-miR-361-3p DUSP9 0.272298288982435 0.0147874880476998 2.74743344854898 1.46260662722122e-19 mirMAP -0.608555740156751 7.06939424892667e-07 NA NA NA hsa-miR-99a-5p DUSP9 -2.344442285007 7.11841214134739e-24 2.74743344854898 1.46260662722122e-19 mirMAP -0.28183238220878 4.5301802985377e-07 NA NA NA hsa-miR-455-3p ECSIT 2.68574446868387 4.28975903022818e-42 -0.403476077189072 8.17821802561068e-05 miRNATAP -0.119769913089845 6.06261078399386e-09 NA NA NA hsa-miR-590-3p EGF 0.221436901462551 0.0965904764063157 -2.10075991194281 5.08275628156253e-09 miRanda -0.330881763767121 0.00576591126865384 NA NA NA hsa-miR-629-3p EGF 1.43262037314105 2.37092217984413e-19 -2.10075991194281 5.08275628156253e-09 miRNATAP -0.795198092528241 2.00645853141744e-17 NA NA NA hsa-miR-125a-5p EGFR 0.215366061934933 0.119550904549401 0.421988255273135 0.0732089026211386 mirMAP -0.438449046612586 2.45858610383153e-09 19881956;27094723;24484870 We report that EGFR signaling leads to transcriptional repression of the miRNA miR-125a through the ETS family transcription factor PEA3;Suppression of microRNA 125a 5p upregulates the TAZ EGFR signaling pathway and promotes retinoblastoma proliferation; Moreover the overexpression of miR-125a-5p led to a decrease in TAZ expression and downstream EGFR signaling pathway activation both in vitro and vivo; Finally TAZ overexpression in retinoblastoma cells overexpressing miR-125a-5p restored retinoblastoma cell proliferation and EGFR pathway activation; Taken together our data demonstrated that miR-125a-5p functions as an important tumor suppressor that suppresses the EGFR pathway by targeting TAZ to inhibit tumor progression in retinoblastoma;miR 125a regulates cell cycle proliferation and apoptosis by targeting the ErbB pathway in acute myeloid leukemia; Profiling revealed the ErbB pathway as significantly decreased with ectopic miR-125a; Either ectopic expression of miR-125a or inhibition of ErbB via Mubritinib resulted in inhibition of cell cycle proliferation and progression with enhanced apoptosis revealing ErbB inhibitors as potential novel therapeutic agents for treating miR-125a-low AML ;progression;progression ovarian cancer;retinoblastoma;acute myeloid leukemia hsa-miR-140-5p EGFR -0.412389003031485 0.000136051708543369 0.421988255273135 0.0732089026211386 miRanda -0.396347951906697 2.8829446407085e-05 NA NA NA hsa-miR-141-3p EGFR 0.730011517758706 0.000120338355004032 0.421988255273135 0.0732089026211386 MirTarget -0.172797280203478 0.00130092154204067 26025929 Treatment with the EGFR inhibitor AG1478 or overexpression of miR141 blocked the activity of ERK downstream of EGFR and inhibited KLF8-depndent cell invasiveness proliferation and viability in cell culture and invasive growth and lung metastasis in nude mice metastasis breast cancer hsa-miR-142-3p EGFR 1.12754191614028 1.68798138028946e-08 0.421988255273135 0.0732089026211386 miRanda -0.211213785673619 2.81655424599246e-05 NA NA NA hsa-miR-146a-5p EGFR -0.0201236699646614 0.905882759106561 0.421988255273135 0.0732089026211386 miRNAWalker2_validate -0.160035522858436 0.00817015681506167 25242818;22161865;25596948;24895573;25417703;23555954;24839931;21632853 Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;MiR 146a suppresses tumor growth and progression by targeting EGFR pathway and in a p ERK dependent manner in castration resistant prostate cancer; Mechanistic studies revealed that miR-146a repressed the expression of EGFR through binding to its 3'-untranslated region; Our findings suggest that ubiquitous loss of miR-146a is a critical mechanism for overexpression of EGFR in CRPC which is crucial to better understanding the pathogenesis of CRPC;Furthermore the expressions of bax and cleaved-caspase-3 mainly were increased in control and overexpression miR-146a groups however the expression of EGFR was inverse; All the results demonstrated that quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells which was performed by up-regulating miR-146a expression then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways and inhibiting invasion through down-regulating the expression of EGFR;Furthermore western blot showed that miR-146a mimic downregulated EGFR ERK1/2 and stat5 signalings; These effects were less potent compared to that of a siRNA targeting EGFR a known target gene of miR-146a; Moreover miR-146a mimic could enhance the cell growth inhibition and apoptosis induction impact of various EGFR targeting agents;Here we report a previously unrecognized posttranscriptional mechanism by which BRCA1 regulates EGFR expression through the induction of miR-146a; We show that BRCA1 binds to MIR146A promoter and activates transcription which in turn attenuates EGFR expression;In functional experiments miR-146a suppressed cell growth induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines H358 H1650 H1975 HCC827 and H292 miR-146a also inhibited the migratory capacity of these NSCLC cells; On the other hand miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR including both TKIs gefitinib erlotinib and afatinib and a monoclonal antibody cetuximab; Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling;Deregulation of miR 146a expression in a mouse model of pancreatic cancer affecting EGFR signaling; Treatment of PC cells with CDF a novel synthetic compound led to re-expression of miR-146a resulting in the down-regulation of EGFR expression; Further knock-down of miR-146a in AsPC-1 cells led to the up-regulation of EGFR expression and showed increased clonogenic growth; In addition knock-down of EGFR by EGFR siRNA transfection of parental AsPC-1 cells and AsPC-1 cells stably transfected with pre-miR-146a resulted in decreased invasive capacity which was further confirmed by reduced luciferase activity in cells transfected with pMIR-Luc reporter vector containing miR-146a binding site; Collectively these results suggest that the loss of expression of miR-146a is a fundamental mechanism for over-expression of EGFR signaling and that re-expression of miR-146a by CDF treatment could be useful in designing personalized strategy for the treatment of human PC;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;progression;;;;;; pancreatic cancer;prostate cancer;breast cancer;liver cancer;breast cancer;lung squamous cell cancer;pancreatic cancer;gastric cancer hsa-miR-146b-5p EGFR 0.917975986853978 3.33749259316025e-09 0.421988255273135 0.0732089026211386 miRNATAP -0.204870248909093 0.00168265901828329 NA NA NA hsa-miR-148b-5p EGFR 1.1533193737265 7.26420964688337e-13 0.421988255273135 0.0732089026211386 mirMAP -0.286420865380633 5.32215159627121e-06 NA NA NA hsa-miR-155-5p EGFR 0.533437622040649 0.00248671179205372 0.421988255273135 0.0732089026211386 miRNAWalker2_validate;MirTarget -0.315457381088104 4.08354886790646e-08 NA NA NA hsa-miR-16-2-3p EGFR 1.1567130855258 1.01867256952189e-14 0.421988255273135 0.0732089026211386 mirMAP -0.358641825525018 6.42478479617906e-08 NA NA NA hsa-miR-16-5p EGFR 0.521122945828175 1.40561786410572e-06 0.421988255273135 0.0732089026211386 miRNAWalker2_validate -0.328580412453127 0.000519061828104517 NA NA NA hsa-miR-17-5p EGFR 1.41924888736771 2.75805544953758e-18 0.421988255273135 0.0732089026211386 TargetScan -0.226636907400546 0.000196756202717447 NA NA NA hsa-miR-186-5p EGFR 0.353452958261612 0.000145058448579496 0.421988255273135 0.0732089026211386 mirMAP -0.576889529374807 1.57349391573345e-07 NA NA NA hsa-miR-188-5p EGFR 0.559328953885106 0.000430338888594543 0.421988255273135 0.0732089026211386 mirMAP -0.24946956675347 0.000110017792853201 NA NA NA hsa-miR-192-5p EGFR 0.380924502586635 0.00986961967409205 0.421988255273135 0.0732089026211386 mirMAP -0.285652307836721 3.76566486689093e-05 NA NA NA hsa-miR-194-3p EGFR 0.735945243226384 8.65425299041628e-05 0.421988255273135 0.0732089026211386 MirTarget -0.203346613744587 0.000253896402950562 NA NA NA hsa-miR-195-3p EGFR -0.624259620429699 0.000164279659144497 0.421988255273135 0.0732089026211386 mirMAP -0.19497730351888 0.00166149772991568 24282590 Plasma levels of miR-195 and miR-122 expression were also associated with overall survival in the patients especially in those with advanced stage HR=0.23 95%CI:0.07-0.84; and HR=0.22 95%CI:0.06-0.77 and EGFR mutation HR=0.27 95%CI:0.08-0.96; and HR=0.23 95%CI=0.06-0.81; Circulating miR-195 and miR-122 may have prognostic values in predicting the overall survival as well as predicting EGFR mutation status in non-smoking female patients with lung adenocarcinoma; Measuring plasma levels of miR-195 and miR-122 may especially be useful in EGFR mutant patients with lung adenocarcinoma staging;poor survival lung cancer hsa-miR-19b-1-5p EGFR 0.757034032029085 2.99828133413343e-07 0.421988255273135 0.0732089026211386 MirTarget;mirMAP -0.264619317805959 0.000116525502311464 NA NA NA hsa-miR-200a-3p EGFR 0.607140814457753 0.00289840524858752 0.421988255273135 0.0732089026211386 MirTarget -0.185851016039293 0.0002060718259245 26184032;19671845 MicroRNA 200a Targets EGFR and c Met to Inhibit Migration Invasion and Gefitinib Resistance in Non Small Cell Lung Cancer; In this study we found that miR-200a is downregulated in NSCLC cells where it directly targets the 3'-UTR of both EGFR and c-Met mRNA; Overexpression of miR-200a in NSCLC cells significantly downregulates both EGFR and c-Met levels and severely inhibits cell migration and invasion;Protein expression and signaling pathway modulation as well as intracellular distribution of EGFR and ERRFI-1 were validated through Western blot analysis and confocal microscopy whereas ERRFI-1 direct target of miR-200 members was validated by using the wild-type and mutant 3'-untranslated region/ERRFI-1/luciferse reporters; We identified a tight association between the expression of miRNAs of the miR-200 family epithelial phenotype and sensitivity to EGFR inhibitors-induced growth inhibition in bladder carcinoma cell lines; The changes in EGFR sensitivity by silencing or forced expression of ERRFI-1 or by miR-200 expression have also been validated in additional cell lines UMUC5 and T24; Members of the miR-200 family appear to control the EMT process and sensitivity to EGFR therapy in bladder cancer cells and the expression of miR-200 is sufficient to restore EGFR dependency at least in some of the mesenchymal bladder cancer cells drug resistance;cell migration; lung squamous cell cancer;bladder cancer hsa-miR-29a-5p EGFR 0.323252792625584 0.0370417231222825 0.421988255273135 0.0732089026211386 mirMAP -0.315796770084768 1.62274156486412e-06 27477273 Feedback Loop Regulation of SCAP/SREBP 1 by miR 29 Modulates EGFR Signaling Driven Glioblastoma Growth glioblastoma hsa-miR-29b-1-5p EGFR 1.39669186711325 4.36960953138935e-11 0.421988255273135 0.0732089026211386 mirMAP -0.139979215565319 0.00326868198559164 NA NA NA hsa-miR-29b-2-5p EGFR -0.502720326849742 0.000730448246894952 0.421988255273135 0.0732089026211386 mirMAP -0.497369532233757 1.56245540377723e-13 NA NA NA hsa-miR-30a-5p EGFR -1.79779915425811 1.93360169837799e-26 0.421988255273135 0.0732089026211386 miRNAWalker2_validate -0.306757641684714 8.20602294984162e-08 NA NA NA hsa-miR-30d-3p EGFR -0.577371911152798 2.02950840095287e-06 0.421988255273135 0.0732089026211386 mirMAP -0.55614047964665 1.90273921147636e-11 NA NA NA hsa-miR-320a EGFR 0.801356001806321 4.91397101474502e-09 0.421988255273135 0.0732089026211386 miRanda;mirMAP -0.4112815999507 1.99503458536141e-08 NA NA NA hsa-miR-339-5p EGFR 1.07771430326938 2.45772601859307e-09 0.421988255273135 0.0732089026211386 miRanda -0.301182089829907 5.46692321863833e-08 NA NA NA hsa-miR-342-3p EGFR 0.99756868977753 9.28499866272332e-10 0.421988255273135 0.0732089026211386 miRanda -0.470164440540375 8.18136541285207e-15 NA NA NA hsa-miR-362-5p EGFR 0.41089772861323 0.0404254902071382 0.421988255273135 0.0732089026211386 mirMAP -0.490166529371809 1.47272058402061e-23 NA NA NA hsa-miR-374a-3p EGFR -0.299190081500425 0.00682975596757891 0.421988255273135 0.0732089026211386 mirMAP -0.471337447459554 3.48991327357632e-07 NA NA NA hsa-miR-491-5p EGFR -0.541680329196715 0.00135829217561865 0.421988255273135 0.0732089026211386 miRanda -0.223393265101076 0.000416870423604875 25299770 This latter effect is due to direct targeting of epidermal growth factor receptor EGFR by miR-491-5p and consequent inhibition of downstream AKT and MAPK signalling pathways; Induction of apoptosis by miR-491-5p in this cell line is mimicked by a combination of EGFR inhibition together with a BH3-mimetic molecule ovarian cancer hsa-miR-501-5p EGFR 1.02806906860218 1.63456814370548e-09 0.421988255273135 0.0732089026211386 mirMAP -0.286508470352779 1.61039937416558e-06 NA NA NA hsa-miR-590-3p EGFR 0.221436901462551 0.0965904764063157 0.421988255273135 0.0732089026211386 mirMAP -0.316063504281599 4.07580543518307e-05 NA NA NA hsa-miR-590-5p EGFR 0.763025362395968 3.65305892505623e-09 0.421988255273135 0.0732089026211386 miRanda;mirMAP -0.335383582937528 1.76757509066129e-05 NA NA NA hsa-miR-7-1-3p EGFR 1.13646121619622 1.49823237535933e-14 0.421988255273135 0.0732089026211386 mirMAP -0.275683965863029 4.44815829786658e-05 NA NA NA hsa-miR-9-5p EGFR 1.65694862043766 2.08325802567323e-05 0.421988255273135 0.0732089026211386 mirMAP -0.148975590966979 7.78083247312223e-09 23365639 We elected to validate our model in vitro by testing the effects of EGFR inhibition on downstream MYC miR-9 and let-7a expression; Our mathematical model explains the signaling link among EGFR MYC and miR-9 but not let-7 lung cancer hsa-let-7a-3p ELK4 0.0966652362351867 0.423761916840503 0.356303519103072 0.00595480968167607 mirMAP -0.191397464340374 4.46480586018177e-05 NA NA NA hsa-miR-145-5p ELK4 -0.46917511594055 0.000685297625493134 0.356303519103072 0.00595480968167607 miRNATAP -0.140613335464447 0.000568096622182483 NA NA NA hsa-miR-16-1-3p ELK4 0.955017760172879 5.95379292601146e-11 0.356303519103072 0.00595480968167607 mirMAP -0.103555708066142 0.00670854297313355 NA NA NA hsa-miR-17-5p ELK4 1.41924888736771 2.75805544953758e-18 0.356303519103072 0.00595480968167607 TargetScan;miRNATAP -0.147755466044595 9.80838411166961e-06 NA NA NA hsa-miR-181a-5p ELK4 0.819060835827404 1.38616688310277e-13 0.356303519103072 0.00595480968167607 mirMAP -0.151220312787697 0.00255764991950109 NA NA NA hsa-miR-181b-5p ELK4 0.974255518824355 2.64876280203475e-16 0.356303519103072 0.00595480968167607 mirMAP -0.139678167677112 0.00256393237975155 NA NA NA hsa-miR-186-5p ELK4 0.353452958261612 0.000145058448579496 0.356303519103072 0.00595480968167607 mirMAP -0.263859008474928 1.43172510875076e-05 NA NA NA hsa-miR-19a-3p ELK4 1.35800152353624 2.80940447111944e-12 0.356303519103072 0.00595480968167607 mirMAP -0.22730870159175 2.10659999148619e-16 NA NA NA hsa-miR-19b-3p ELK4 0.538732279378089 0.000622008277870679 0.356303519103072 0.00595480968167607 mirMAP -0.312207039316985 1.80293282485284e-19 NA NA NA hsa-miR-20a-5p ELK4 1.1531986665452 1.02385132917958e-11 0.356303519103072 0.00595480968167607 miRNATAP -0.188522160168213 5.32368438821761e-09 NA NA NA hsa-miR-26b-5p ELK4 -0.254478038884324 0.0285227763044636 0.356303519103072 0.00595480968167607 mirMAP -0.284741899932026 3.69322813734642e-09 NA NA NA hsa-miR-29a-5p ELK4 0.323252792625584 0.0370417231222825 0.356303519103072 0.00595480968167607 mirMAP -0.254054314601866 1.24914494886013e-12 NA NA NA hsa-miR-30a-5p ELK4 -1.79779915425811 1.93360169837799e-26 0.356303519103072 0.00595480968167607 mirMAP -0.125665879574927 7.30859532422767e-05 NA NA NA hsa-miR-30b-5p ELK4 -0.400238605368173 0.00346540992719245 0.356303519103072 0.00595480968167607 mirMAP -0.265318978369202 6.64772888709078e-11 NA NA NA hsa-miR-30c-5p ELK4 0.021222006155897 0.886366656528128 0.356303519103072 0.00595480968167607 mirMAP -0.314621637264943 2.10837495414705e-17 NA NA NA hsa-miR-338-3p ELK4 -0.948755228846395 8.99167125682392e-08 0.356303519103072 0.00595480968167607 MirTarget;miRanda -0.292630889270311 3.7746761311593e-22 NA NA NA hsa-miR-342-3p ELK4 0.99756868977753 9.28499866272332e-10 0.356303519103072 0.00595480968167607 mirMAP -0.203864703158898 1.46644004424191e-09 NA NA NA hsa-miR-362-5p ELK4 0.41089772861323 0.0404254902071382 0.356303519103072 0.00595480968167607 mirMAP -0.236233819413596 4.89138161156677e-18 NA NA NA hsa-miR-365a-3p ELK4 0.446833934952926 0.00233857759218299 0.356303519103072 0.00595480968167607 mirMAP -0.30025792119848 1.11990916055708e-15 NA NA NA hsa-miR-369-3p ELK4 -1.2344419076994 2.66882944171146e-10 0.356303519103072 0.00595480968167607 mirMAP -0.104393400280066 0.00024115348542385 NA NA NA hsa-miR-495-3p ELK4 -1.47803501311999 6.88839745293927e-13 0.356303519103072 0.00595480968167607 mirMAP -0.116916893966993 1.25676297499967e-05 NA NA NA hsa-miR-500a-5p ELK4 0.675401699376111 8.24389004707854e-05 0.356303519103072 0.00595480968167607 mirMAP -0.228908677348117 1.03955581914037e-12 NA NA NA hsa-miR-501-5p ELK4 1.02806906860218 1.63456814370548e-09 0.356303519103072 0.00595480968167607 mirMAP -0.149012006737153 5.98891436521894e-06 NA NA NA hsa-miR-582-5p ELK4 -0.0366995972742474 0.821827119138923 0.356303519103072 0.00595480968167607 mirMAP -0.125442122620465 0.00030017176005277 NA NA NA hsa-miR-589-3p ELK4 1.59559692667315 6.2886410639161e-15 0.356303519103072 0.00595480968167607 mirMAP -0.106638986818162 0.000133520393706573 NA NA NA hsa-miR-590-5p ELK4 0.763025362395968 3.65305892505623e-09 0.356303519103072 0.00595480968167607 mirMAP -0.137395531960711 0.00146394319957642 NA NA NA hsa-miR-660-5p ELK4 -0.202705992887645 0.101093376073573 0.356303519103072 0.00595480968167607 mirMAP -0.313930220447967 3.31525973400829e-12 NA NA NA hsa-miR-664a-3p ELK4 -0.256108763664991 0.0513188660751664 0.356303519103072 0.00595480968167607 mirMAP -0.241462140901688 1.53374536614395e-08 NA NA NA hsa-miR-361-5p FAS 0.0803683277369505 0.314043140368058 -0.353746390296431 0.0224836395610983 miRanda -0.254638067114056 0.00313062697979385 NA NA NA hsa-miR-590-5p FAS 0.763025362395968 3.65305892505623e-09 -0.353746390296431 0.0224836395610983 miRanda -0.179002441556527 0.000520949899474374 NA NA NA hsa-let-7e-5p FASLG 0.0857356192778891 0.512869729833211 0.394703525705912 0.21882393973136 miRNATAP -0.353388568642215 0.000974735688504158 NA NA NA hsa-miR-199a-5p FASLG -0.364835768178638 0.0435119211101981 0.394703525705912 0.21882393973136 miRanda -0.273318512204072 0.000400614015733864 NA NA NA hsa-miR-452-3p FASLG 1.09618110917892 2.21867884261816e-07 0.394703525705912 0.21882393973136 mirMAP -0.298192608882689 4.3334365675638e-06 NA NA NA hsa-miR-18a-5p FGF1 1.65455873230328 3.76457892277775e-20 -0.258011343667108 0.26760431731263 MirTarget -0.277496437672487 2.43959718026235e-07 NA NA NA hsa-miR-193a-3p FGF1 0.22120710726779 0.111827069464729 -0.258011343667108 0.26760431731263 PITA -0.202240172681954 0.00567870004542482 NA NA NA hsa-miR-205-5p FGF1 1.50759485376634 2.0003886738248e-16 -0.258011343667108 0.26760431731263 mirMAP -0.198163178508369 0.000211883664826537 NA NA NA hsa-miR-2355-5p FGF1 1.47205546931107 8.65192179636668e-19 -0.258011343667108 0.26760431731263 MirTarget -0.185602955162296 0.00160680328845676 NA NA NA hsa-miR-484 FGF1 0.918280909791707 1.39168306854263e-14 -0.258011343667108 0.26760431731263 MirTarget;PITA;miRNATAP -0.389291918702885 2.4520525029842e-06 NA NA NA hsa-miR-532-3p FGF1 0.80240056676907 1.08989551712617e-09 -0.258011343667108 0.26760431731263 miRNATAP -0.216024621372653 0.004507077796501 NA NA NA hsa-miR-576-5p FGF1 0.940432050128373 6.90227595663302e-12 -0.258011343667108 0.26760431731263 PITA;mirMAP -0.292914912309583 5.16069042343911e-05 NA NA NA hsa-miR-590-5p FGF1 0.763025362395968 3.65305892505623e-09 -0.258011343667108 0.26760431731263 MirTarget;miRanda;miRNATAP -0.317241137495249 3.95390401682399e-05 NA NA NA hsa-miR-629-5p FGF1 0.461215538037447 8.95262667860215e-06 -0.258011343667108 0.26760431731263 MirTarget -0.658892526979509 6.2109593316048e-12 NA NA NA hsa-miR-944 FGF1 1.47323925060177 2.61626403984929e-13 -0.258011343667108 0.26760431731263 mirMAP -0.319683604411362 3.57117911228316e-11 NA NA NA hsa-let-7f-5p FGF11 -0.441845198213823 0.00242957484218694 0.817619191220799 0.000125130498795574 mirMAP;miRNATAP -0.252953039973085 7.44143657639289e-05 NA NA NA hsa-let-7g-5p FGF11 -0.250780249469264 0.00939610188330072 0.817619191220799 0.000125130498795574 mirMAP;miRNATAP -0.370971716833525 0.000137291311349804 NA NA NA hsa-miR-125b-5p FGF11 -0.993460109818276 5.07736727659894e-12 0.817619191220799 0.000125130498795574 mirMAP -0.24169989978906 0.000142160166852154 NA NA NA hsa-miR-181c-5p FGF11 -0.168991199007857 0.196949106150297 0.817619191220799 0.000125130498795574 mirMAP -0.20614633962775 0.00401693406111408 NA NA NA hsa-miR-195-5p FGF11 -1.8367376818177 6.9944883988895e-31 0.817619191220799 0.000125130498795574 mirMAP -0.198302055931528 0.000331638911045397 NA NA NA hsa-miR-217 FGF11 -1.35391381055929 2.42394951427902e-09 0.817619191220799 0.000125130498795574 PITA;miRanda -0.10449304001688 0.0099270377926623 NA NA NA hsa-miR-221-5p FGF11 -0.53190793287441 0.0379158336541952 0.817619191220799 0.000125130498795574 miRNATAP -0.119704813324824 0.000984850545712735 NA NA NA hsa-miR-28-5p FGF11 -0.026996999089909 0.733047113251652 0.817619191220799 0.000125130498795574 miRanda -0.404088723713172 0.000764907597908066 NA NA NA hsa-miR-326 FGF11 -0.425943992128769 0.0415010315530797 0.817619191220799 0.000125130498795574 MirTarget;PITA;miRanda;miRNATAP -0.205709585070413 3.91411336469149e-06 NA NA NA hsa-miR-628-5p FGF11 -0.554239048796013 4.92386883216087e-05 0.817619191220799 0.000125130498795574 miRNATAP -0.361198975570433 8.93992785542876e-08 NA NA NA hsa-miR-142-5p FGF12 0.288897753038094 0.0900009317815725 -0.582614717688515 0.0551727720869136 miRNATAP -0.329957050688491 2.05218174125255e-05 NA NA NA hsa-miR-205-3p FGF12 1.2960640797621 5.80786479909147e-11 -0.582614717688515 0.0551727720869136 MirTarget -0.272629135698617 3.0622926253504e-05 NA NA NA hsa-miR-2355-3p FGF12 1.58434563546762 4.06578912176206e-18 -0.582614717688515 0.0551727720869136 MirTarget;miRNATAP -0.38448285919751 3.04446467725463e-08 NA NA NA hsa-miR-29a-5p FGF12 0.323252792625584 0.0370417231222825 -0.582614717688515 0.0551727720869136 MirTarget -0.38111533263344 7.52153613120094e-06 NA NA NA hsa-miR-342-3p FGF12 0.99756868977753 9.28499866272332e-10 -0.582614717688515 0.0551727720869136 miRanda -0.340856513705552 1.90111712777334e-05 NA NA NA hsa-miR-450b-5p FGF12 1.25529820885833 1.18847120528666e-15 -0.582614717688515 0.0551727720869136 miRNATAP -0.237099192523695 0.00393637076050291 NA NA NA hsa-miR-455-5p FGF12 1.408595672323 5.52039116456697e-22 -0.582614717688515 0.0551727720869136 miRanda -0.551210175951459 1.29665519180675e-10 NA NA NA hsa-miR-511-5p FGF12 0.214339847118675 0.232372953100021 -0.582614717688515 0.0551727720869136 MirTarget -0.232230880342727 0.00166625415209001 NA NA NA hsa-miR-542-3p FGF12 0.643308814904977 8.81635403230104e-07 -0.582614717688515 0.0551727720869136 miRanda -0.329632103105734 0.00104162237655472 NA NA NA hsa-miR-576-5p FGF12 0.940432050128373 6.90227595663302e-12 -0.582614717688515 0.0551727720869136 mirMAP -0.408242189119232 1.55698433321357e-05 NA NA NA hsa-let-7b-3p FGF13 0.120166961637302 0.299224004314356 -1.46301246813209 1.10281013324847e-05 MirTarget;miRNATAP -0.395582167462648 0.00186130582510831 NA NA NA hsa-let-7f-1-3p FGF13 0.700374242293247 8.65000484720084e-08 -1.46301246813209 1.10281013324847e-05 MirTarget -0.413328586300836 0.000184731392195485 NA NA NA hsa-miR-141-3p FGF13 0.730011517758706 0.000120338355004032 -1.46301246813209 1.10281013324847e-05 TargetScan -0.217008682104236 0.00461729582654458 NA NA NA hsa-miR-142-5p FGF13 0.288897753038094 0.0900009317815725 -1.46301246813209 1.10281013324847e-05 PITA -0.257065161129666 0.00275687664306998 NA NA NA hsa-miR-31-3p FGF13 2.10124531535908 1.70135756565194e-08 -1.46301246813209 1.10281013324847e-05 miRNATAP -0.318757205751666 1.9138000549862e-17 NA NA NA hsa-miR-3682-3p FGF13 0.707626231028898 1.50609185515014e-05 -1.46301246813209 1.10281013324847e-05 MirTarget -0.251232120368971 0.00488545679786259 NA NA NA hsa-miR-455-5p FGF13 1.408595672323 5.52039116456697e-22 -1.46301246813209 1.10281013324847e-05 PITA;miRanda -0.744922261520023 1.82247837214577e-15 NA NA NA hsa-miR-7-1-3p FGF13 1.13646121619622 1.49823237535933e-14 -1.46301246813209 1.10281013324847e-05 MirTarget;mirMAP -0.347115115224032 0.000314178039831248 NA NA NA hsa-miR-193a-5p FGF14 0.351460703308937 0.00347717541215117 -1.62704249037492 1.3148897101317e-07 TargetScan -0.406581901327017 0.0003265222795513 NA NA NA hsa-miR-590-3p FGF14 0.221436901462551 0.0965904764063157 -1.62704249037492 1.3148897101317e-07 miRanda -0.42830851823148 2.68300448941013e-05 NA NA NA hsa-miR-96-5p FGF14 1.42326703011157 4.39736150032373e-14 -1.62704249037492 1.3148897101317e-07 TargetScan -0.337834021759798 1.31045376791808e-06 NA NA NA hsa-miR-103a-3p FGF18 0.556219385347418 1.55815736455067e-09 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.496370794423683 0.000332281911081466 NA NA NA hsa-miR-15a-5p FGF18 0.783550182002274 2.60699595655907e-11 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.702693009108968 3.09754498733063e-11 NA NA NA hsa-miR-15b-5p FGF18 0.85315666454713 3.79816274836297e-12 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.546279443338623 7.76425760723514e-08 NA NA NA hsa-miR-16-5p FGF18 0.521122945828175 1.40561786410572e-06 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.634380188554347 6.35545983795006e-08 NA NA NA hsa-miR-200b-3p FGF18 0.0717138787925347 0.682858087587209 -1.88786711762185 6.1965148779705e-11 TargetScan -0.338800867319404 3.20904303944546e-06 NA NA NA hsa-miR-200c-3p FGF18 0.630251054099546 0.000131975031451555 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.491042406920311 1.19246477608829e-10 NA NA NA hsa-miR-21-5p FGF18 1.62465922021121 3.44191300985109e-58 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.522565820217367 3.80501286581297e-06 NA NA NA hsa-miR-330-5p FGF18 0.944693925383906 5.04972895657346e-13 -1.88786711762185 6.1965148779705e-11 PITA;miRanda;miRNATAP -0.364911036381969 0.000141889829673744 NA NA NA hsa-miR-424-5p FGF18 1.48125289532143 9.10372985713165e-19 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.411226086316741 1.91859919749703e-08 NA NA NA hsa-miR-429 FGF18 0.559451508722375 0.00563641638673083 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.383425444613611 8.10623231086834e-10 NA NA NA hsa-miR-505-3p FGF18 0.912823669571645 4.0549774967148e-13 -1.88786711762185 6.1965148779705e-11 miRNATAP -0.45816431477501 4.02225324767235e-06 NA NA NA hsa-miR-590-5p FGF18 0.763025362395968 3.65305892505623e-09 -1.88786711762185 6.1965148779705e-11 miRanda;miRNATAP -0.628733840517059 7.22877221668898e-11 NA NA NA hsa-miR-193a-3p FGF19 0.22120710726779 0.111827069464729 1.92934227956647 8.15438676803874e-05 miRanda -0.541295534008293 0.000464328018223873 NA NA NA hsa-let-7a-3p FGF2 0.0966652362351867 0.423761916840503 -0.873895268607156 0.000749629544409884 mirMAP -0.346697326213815 0.000235155196874588 NA NA NA hsa-miR-15a-5p FGF2 0.783550182002274 2.60699595655907e-11 -0.873895268607156 0.000749629544409884 MirTarget;miRNATAP -0.337568241456238 0.000380629759701841 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-1-3p FGF2 0.955017760172879 5.95379292601146e-11 -0.873895268607156 0.000749629544409884 mirMAP -0.216053774665656 0.00482669676692554 NA NA NA hsa-miR-19b-1-5p FGF2 0.757034032029085 2.99828133413343e-07 -0.873895268607156 0.000749629544409884 mirMAP -0.299411866060348 7.91846938731196e-05 NA NA NA hsa-miR-20a-3p FGF2 1.34885093664027 2.07697464119202e-12 -0.873895268607156 0.000749629544409884 mirMAP -0.254686140332496 9.5611184793422e-06 NA NA NA hsa-miR-21-3p FGF2 1.25126438776674 2.4124216716282e-17 -0.873895268607156 0.000749629544409884 mirMAP -0.32497551048351 1.17275178306699e-05 NA NA NA hsa-miR-21-5p FGF2 1.62465922021121 3.44191300985109e-58 -0.873895268607156 0.000749629544409884 mirMAP -0.383531284677615 0.000132348473852467 NA NA NA hsa-miR-221-3p FGF2 0.410625614724387 0.000741090075261272 -0.873895268607156 0.000749629544409884 mirMAP -0.449825295563516 1.20603425503909e-06 NA NA NA hsa-miR-222-3p FGF2 1.08197052578759 2.32604040301699e-14 -0.873895268607156 0.000749629544409884 mirMAP -0.480077702405072 4.64663204454521e-10 NA NA NA hsa-miR-424-5p FGF2 1.48125289532143 9.10372985713165e-19 -0.873895268607156 0.000749629544409884 MirTarget;miRNATAP -0.246395124820535 0.000160269078978561 NA NA NA hsa-miR-429 FGF2 0.559451508722375 0.00563641638673083 -0.873895268607156 0.000749629544409884 mirMAP -0.179751399599829 0.00131313676812878 NA NA NA hsa-miR-450b-5p FGF2 1.25529820885833 1.18847120528666e-15 -0.873895268607156 0.000749629544409884 mirMAP -0.227108898055622 0.001244749731088 NA NA NA hsa-miR-452-5p FGF2 0.373288744398455 0.0348485937209964 -0.873895268607156 0.000749629544409884 mirMAP -0.346192872192568 4.93639730457593e-08 NA NA NA hsa-miR-503-5p FGF2 2.85210590411715 1.27298190263569e-35 -0.873895268607156 0.000749629544409884 miRNAWalker2_validate -0.222158187558667 3.87633414352609e-06 NA NA NA hsa-miR-589-3p FGF2 1.59559692667315 6.2886410639161e-15 -0.873895268607156 0.000749629544409884 mirMAP -0.162744204065903 0.00378641086950463 NA NA NA hsa-miR-590-5p FGF2 0.763025362395968 3.65305892505623e-09 -0.873895268607156 0.000749629544409884 miRanda;mirMAP -0.362188154730295 2.75175904757516e-05 NA NA NA hsa-miR-92a-3p FGF2 0.994679542307232 1.32587679156217e-16 -0.873895268607156 0.000749629544409884 miRNAWalker2_validate -0.350572454919679 0.000131198641822221 NA NA NA hsa-miR-944 FGF2 1.47323925060177 2.61626403984929e-13 -0.873895268607156 0.000749629544409884 MirTarget -0.297247292575655 4.68482644368958e-08 NA NA NA hsa-miR-155-5p FGF5 0.533437622040649 0.00248671179205372 2.03532963351149 1.96791908743617e-07 mirMAP -0.31284053064953 0.00133764239981059 NA NA NA hsa-miR-15b-5p FGF5 0.85315666454713 3.79816274836297e-12 2.03532963351149 1.96791908743617e-07 miRNAWalker2_validate -0.539510689376273 8.89932041304568e-05 NA NA NA hsa-miR-16-1-3p FGF5 0.955017760172879 5.95379292601146e-11 2.03532963351149 1.96791908743617e-07 mirMAP -0.435673839937129 0.000178123016562154 NA NA NA hsa-miR-30b-5p FGF5 -0.400238605368173 0.00346540992719245 2.03532963351149 1.96791908743617e-07 mirMAP -0.584264957941181 3.11677593098393e-06 NA NA NA hsa-miR-30c-5p FGF5 0.021222006155897 0.886366656528128 2.03532963351149 1.96791908743617e-07 mirMAP -0.414523178107725 0.000368274960248606 NA NA NA hsa-miR-30d-5p FGF5 -0.38399848121878 0.000171129616944749 2.03532963351149 1.96791908743617e-07 mirMAP -0.830892592830511 7.77553120763636e-07 NA NA NA hsa-miR-30e-5p FGF5 -1.02114836019762 6.81961221797866e-17 2.03532963351149 1.96791908743617e-07 mirMAP -1.010076240996 5.35877622269213e-14 NA NA NA hsa-miR-33a-3p FGF5 0.20371038027126 0.212335697664505 2.03532963351149 1.96791908743617e-07 mirMAP -0.564415390474596 1.13151442887737e-07 NA NA NA hsa-miR-3607-3p FGF5 1.01377165357363 9.13355519701165e-05 2.03532963351149 1.96791908743617e-07 miRNATAP -0.243752423074476 0.000221294949256888 NA NA NA hsa-miR-374a-5p FGF5 -0.621903385111545 6.61791773205282e-12 2.03532963351149 1.96791908743617e-07 mirMAP -0.578953744206145 0.00214972210165144 NA NA NA hsa-miR-374b-5p FGF5 -0.288413933608091 0.0041474558664058 2.03532963351149 1.96791908743617e-07 mirMAP -0.460448246804867 0.00769448722291093 NA NA NA hsa-miR-582-5p FGF5 -0.0366995972742474 0.821827119138923 2.03532963351149 1.96791908743617e-07 mirMAP -0.438895718657925 3.30028681894977e-05 NA NA NA hsa-miR-7-1-3p FGF5 1.13646121619622 1.49823237535933e-14 2.03532963351149 1.96791908743617e-07 mirMAP -0.491319043524203 1.46162304642574e-05 NA NA NA hsa-miR-9-5p FGF5 1.65694862043766 2.08325802567323e-05 2.03532963351149 1.96791908743617e-07 mirMAP;miRNATAP -0.319095858366486 1.04359689832769e-13 NA NA NA hsa-let-7a-3p FGF7 0.0966652362351867 0.423761916840503 -2.01548136096491 3.47916106415079e-16 MirTarget;miRNATAP -0.407412421508281 9.39576644959233e-06 NA NA NA hsa-miR-15a-5p FGF7 0.783550182002274 2.60699595655907e-11 -2.01548136096491 3.47916106415079e-16 miRTarBase;miRNATAP -0.758176143394721 5.17214837920814e-17 NA NA NA hsa-miR-15b-5p FGF7 0.85315666454713 3.79816274836297e-12 -2.01548136096491 3.47916106415079e-16 miRNATAP -0.568341530637 8.06625251176299e-11 NA NA NA hsa-miR-16-1-3p FGF7 0.955017760172879 5.95379292601146e-11 -2.01548136096491 3.47916106415079e-16 mirMAP -0.582550949106155 1.52037236233235e-15 NA NA NA hsa-miR-16-2-3p FGF7 1.1567130855258 1.01867256952189e-14 -2.01548136096491 3.47916106415079e-16 mirMAP -0.662388065162359 1.98377986171799e-21 NA NA NA hsa-miR-16-5p FGF7 0.521122945828175 1.40561786410572e-06 -2.01548136096491 3.47916106415079e-16 miRNATAP -0.528266917563882 2.01078150816863e-07 NA NA NA hsa-miR-18a-3p FGF7 1.82583720936229 7.51297960972179e-19 -2.01548136096491 3.47916106415079e-16 MirTarget -0.46844558781355 1.08349793094373e-19 NA NA NA hsa-miR-205-3p FGF7 1.2960640797621 5.80786479909147e-11 -2.01548136096491 3.47916106415079e-16 mirMAP -0.547481712642976 1.77873769265097e-25 NA NA NA hsa-miR-20a-5p FGF7 1.1531986665452 1.02385132917958e-11 -2.01548136096491 3.47916106415079e-16 miRNAWalker2_validate -0.613419630660297 2.02970970138624e-23 NA NA NA hsa-miR-27a-3p FGF7 0.348456440505425 0.00126682892514312 -2.01548136096491 3.47916106415079e-16 MirTarget -0.485890878724566 2.08331319035218e-06 NA NA NA hsa-miR-31-5p FGF7 2.79079137807505 1.72181058015659e-13 -2.01548136096491 3.47916106415079e-16 MirTarget -0.251497031870126 2.0735964251059e-19 NA NA NA hsa-miR-320a FGF7 0.801356001806321 4.91397101474502e-09 -2.01548136096491 3.47916106415079e-16 miRanda -0.344732081653175 1.52541649148947e-05 NA NA NA hsa-miR-320b FGF7 1.23473838180754 3.04337566045537e-14 -2.01548136096491 3.47916106415079e-16 miRanda -0.306922120859187 3.56854180676285e-06 NA NA NA hsa-miR-33a-3p FGF7 0.20371038027126 0.212335697664505 -2.01548136096491 3.47916106415079e-16 mirMAP -0.267156731589519 0.000105178848642306 NA NA NA hsa-miR-3607-3p FGF7 1.01377165357363 9.13355519701165e-05 -2.01548136096491 3.47916106415079e-16 mirMAP -0.231628164127034 3.82613094762849e-08 NA NA NA hsa-miR-424-5p FGF7 1.48125289532143 9.10372985713165e-19 -2.01548136096491 3.47916106415079e-16 miRNATAP -0.320726779959208 4.43814875864373e-07 NA NA NA hsa-miR-429 FGF7 0.559451508722375 0.00563641638673083 -2.01548136096491 3.47916106415079e-16 miRNATAP -0.456460483342231 8.35745432718304e-18 NA NA NA hsa-miR-452-5p FGF7 0.373288744398455 0.0348485937209964 -2.01548136096491 3.47916106415079e-16 mirMAP -0.295494838128618 2.11954883967322e-06 NA NA NA hsa-miR-455-3p FGF7 2.68574446868387 4.28975903022818e-42 -2.01548136096491 3.47916106415079e-16 PITA;miRNATAP -0.510499869886505 3.92708976432283e-25 NA NA NA hsa-miR-484 FGF7 0.918280909791707 1.39168306854263e-14 -2.01548136096491 3.47916106415079e-16 PITA -0.553887894998084 6.92443925890007e-10 NA NA NA hsa-miR-501-5p FGF7 1.02806906860218 1.63456814370548e-09 -2.01548136096491 3.47916106415079e-16 PITA;mirMAP -0.268272897559334 3.42494201805503e-05 NA NA NA hsa-miR-590-3p FGF7 0.221436901462551 0.0965904764063157 -2.01548136096491 3.47916106415079e-16 PITA;miRanda;mirMAP;miRNATAP -0.27812954133398 0.000866348391234384 NA NA NA hsa-miR-590-5p FGF7 0.763025362395968 3.65305892505623e-09 -2.01548136096491 3.47916106415079e-16 PITA;miRanda -0.701558117453836 1.5867556887698e-17 NA NA NA hsa-miR-7-1-3p FGF7 1.13646121619622 1.49823237535933e-14 -2.01548136096491 3.47916106415079e-16 mirMAP -0.458342824311289 2.15620787170561e-10 NA NA NA hsa-miR-708-3p FGF7 1.32647174389322 4.87465491977979e-16 -2.01548136096491 3.47916106415079e-16 mirMAP -0.437698752984361 1.47737195240182e-11 NA NA NA hsa-miR-944 FGF7 1.47323925060177 2.61626403984929e-13 -2.01548136096491 3.47916106415079e-16 mirMAP -0.37225697445087 1.67116584248206e-12 NA NA NA hsa-miR-142-3p FGF9 1.12754191614028 1.68798138028946e-08 -1.38200824505352 9.05347102190895e-06 miRanda -0.259765933502149 0.000113295496265394 NA NA NA hsa-miR-15a-5p FGF9 0.783550182002274 2.60699595655907e-11 -1.38200824505352 9.05347102190895e-06 miRNATAP -0.357865605085935 0.0018124991757053 NA NA NA hsa-miR-16-2-3p FGF9 1.1567130855258 1.01867256952189e-14 -1.38200824505352 9.05347102190895e-06 mirMAP -0.375706331819685 2.36450540389056e-05 NA NA NA hsa-miR-205-5p FGF9 1.50759485376634 2.0003886738248e-16 -1.38200824505352 9.05347102190895e-06 miRNATAP -0.416585862637498 5.72993182011151e-09 NA NA NA hsa-miR-330-5p FGF9 0.944693925383906 5.04972895657346e-13 -1.38200824505352 9.05347102190895e-06 miRanda;miRNATAP -0.282467140589527 0.00592832027325082 NA NA NA hsa-miR-455-5p FGF9 1.408595672323 5.52039116456697e-22 -1.38200824505352 9.05347102190895e-06 miRanda -0.519010790529783 5.18865705861902e-09 NA NA NA hsa-miR-590-5p FGF9 0.763025362395968 3.65305892505623e-09 -1.38200824505352 9.05347102190895e-06 miRanda -0.334500927773077 0.00137367059889734 NA NA NA hsa-miR-744-3p FGF9 1.18973028739247 4.23716909078104e-10 -1.38200824505352 9.05347102190895e-06 miRNATAP -0.209668103890808 0.00297574939478547 NA NA NA hsa-miR-944 FGF9 1.47323925060177 2.61626403984929e-13 -1.38200824505352 9.05347102190895e-06 mirMAP -0.244896095804246 0.000212430618962972 NA NA NA hsa-miR-96-5p FGF9 1.42326703011157 4.39736150032373e-14 -1.38200824505352 9.05347102190895e-06 TargetScan;miRNATAP -0.191745648143166 0.00674766951778037 NA NA NA hsa-miR-106a-5p FGFR1 0.67978010057847 0.00221925869726092 -0.285304743310302 0.171119486865196 mirMAP -0.129847841479432 0.00140745214014729 NA NA NA hsa-miR-135b-5p FGFR1 1.5570143078477 4.60753610971455e-13 -0.285304743310302 0.171119486865196 mirMAP -0.281548954961466 3.25890310081625e-12 NA NA NA hsa-miR-15a-5p FGFR1 0.783550182002274 2.60699595655907e-11 -0.285304743310302 0.171119486865196 miRNATAP -0.403658939025052 8.79750014830109e-08 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-15b-5p FGFR1 0.85315666454713 3.79816274836297e-12 -0.285304743310302 0.171119486865196 miRNATAP -0.214437670759984 0.00317282993888603 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-16-5p FGFR1 0.521122945828175 1.40561786410572e-06 -0.285304743310302 0.171119486865196 miRTarBase;miRNATAP -0.38922203488893 3.0006114587061e-06 21532615 Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts CAFs promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1 which act on both stromal and tumor cells to enhance cancer cell survival proliferation and migration progression;poor survival prostate cancer hsa-miR-17-5p FGFR1 1.41924888736771 2.75805544953758e-18 -0.285304743310302 0.171119486865196 mirMAP -0.338598823690165 1.88464331446601e-10 NA NA NA hsa-miR-200a-5p FGFR1 0.701063526850019 0.000188402923774663 -0.285304743310302 0.171119486865196 mirMAP -0.347565186416522 1.54236670618255e-13 NA NA NA hsa-miR-200b-5p FGFR1 0.02621402664548 0.883725338810228 -0.285304743310302 0.171119486865196 mirMAP -0.319684954127201 1.58203496685162e-10 NA NA NA hsa-miR-20a-5p FGFR1 1.1531986665452 1.02385132917958e-11 -0.285304743310302 0.171119486865196 mirMAP -0.317108473561725 9.27549337118698e-10 NA NA NA hsa-miR-2355-5p FGFR1 1.47205546931107 8.65192179636668e-19 -0.285304743310302 0.171119486865196 mirMAP -0.299822634669823 8.84769794668989e-09 NA NA NA hsa-miR-301a-3p FGFR1 2.14132004241926 4.46255413526808e-25 -0.285304743310302 0.171119486865196 mirMAP -0.169994723601377 4.35783491979539e-05 NA NA NA hsa-miR-455-5p FGFR1 1.408595672323 5.52039116456697e-22 -0.285304743310302 0.171119486865196 miRanda -0.313824859592463 1.11413040800983e-07 NA NA NA hsa-miR-590-3p FGFR1 0.221436901462551 0.0965904764063157 -0.285304743310302 0.171119486865196 miRanda;mirMAP -0.267304203534255 8.80534628406325e-05 NA NA NA hsa-miR-93-5p FGFR1 1.61042951896619 5.1280369606967e-24 -0.285304743310302 0.171119486865196 mirMAP -0.169176457028053 0.00188566230333975 NA NA NA hsa-let-7a-3p FGFR2 0.0966652362351867 0.423761916840503 -0.689192404124544 0.00027530593494015 miRNATAP -0.193564939031614 0.00509899325895667 NA NA NA hsa-miR-146b-5p FGFR2 0.917975986853978 3.33749259316025e-09 -0.689192404124544 0.00027530593494015 miRanda -0.315268061524928 1.36606510703905e-09 NA NA NA hsa-miR-186-5p FGFR2 0.353452958261612 0.000145058448579496 -0.689192404124544 0.00027530593494015 miRNAWalker2_validate -0.392401143571198 1.09634780638378e-05 NA NA NA hsa-miR-193a-3p FGFR2 0.22120710726779 0.111827069464729 -0.689192404124544 0.00027530593494015 miRanda -0.357501509299468 1.39512863622931e-09 NA NA NA hsa-miR-330-5p FGFR2 0.944693925383906 5.04972895657346e-13 -0.689192404124544 0.00027530593494015 miRanda -0.214084238420235 0.000567628023207746 NA NA NA hsa-miR-338-3p FGFR2 -0.948755228846395 8.99167125682392e-08 -0.689192404124544 0.00027530593494015 miRanda;miRNATAP -0.175050696307873 0.000145068088792403 NA NA NA hsa-miR-542-3p FGFR2 0.643308814904977 8.81635403230104e-07 -0.689192404124544 0.00027530593494015 miRanda -0.356945364566282 9.9855269919112e-09 NA NA NA hsa-miR-100-5p FGFR3 -1.85857794619369 1.248973638996e-25 0.0735667865321687 0.750912348559634 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.177527076547578 0.00100959147184781 25344675;26604796;26018508;23778527 MicroRNA 100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3; The predicted target of miR-100 fibroblast growth factor receptor 3 FGFR3 was downregulated by siRNA to examine its effect on pancreatic cancer cells; Luciferase essay showed FGFR3 was direct target of miR-100; FGFR3 was significantly downregulated by overexpressing miR-100 in pancreatic cancer cells and knocking down FGFR3 by siRNA exerted similar effect as miR-100; Our study demonstrated that miR-100 played an important role in pancreatic cancer development possibly through targeting FGFR3;Overexpression of miR 100 inhibits cell proliferation migration and chemosensitivity in human glioblastoma through FGFR3; Expression of fibroblast growth factor receptor 3 FGFR3 the bioinformatically predicted target of miR-100 was examined by Western blot in glioblastoma; FGFR3 was directly regulated by miR-100 in glioblastoma; Ectopically overexpressing FGFR3 was able to ameliorate the anticancer effects of upregulation of miR-100 on glioblastoma growth migration and chemosensitivity; Overexpressing miR-100 had anticancer effects on glioblastoma likely through regulation of FGFR3;Overexpression of miR 100 inhibits growth of osteosarcoma through FGFR3; Here we reported significantly higher levels of fibroblast growth factor receptor 3 FGFR3 and significantly lower levels of miR-100 in the OS specimen compared to those in the paired normal bone tissues; Bioinformatics analysis and luciferase reporter assay suggest that miR-100 binds to the 3'UTR of FGFR3 mRNA to prevent its translation; Taken together our data demonstrate that miR-100 may inhibit the growth of OS through FGFR3;Hypoxia regulates FGFR3 expression via HIF 1α and miR 100 and contributes to cell survival in non muscle invasive bladder cancer; We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100; In this study we investigated the effects of hypoxia on miR-100 and FGFR3 expression and the link between miR-100 and FGFR3 in hypoxia; Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR qPCR and western blotting and miR-100 by qPCR; The effect of FGFR3 and miR-100 on cell viability in two-dimensional 2-D and three-dimensional 3-D was examined by transfecting siRNA or mimic-100 respectively; Increased FGFR3 was also in part dependent on miR-100 levels which decreased in hypoxia; Hypoxia in part via suppression of miR-100 induces FGFR3 expression in bladder cancer both of which have an important role in maintaining cell viability under conditions of stress ;;;poor survival pancreatic cancer;glioblastoma;sarcoma;bladder cancer hsa-miR-337-3p FGFR3 -1.70091836051933 1.39844536073221e-13 0.0735667865321687 0.750912348559634 MirTarget -0.158736976879148 0.000197575798793529 NA NA NA hsa-miR-99b-5p FGFR3 0.44137573438014 9.0939587647735e-05 0.0735667865321687 0.750912348559634 MirTarget;miRNATAP -0.313791397643478 0.000443612699243026 22969861 miR-99b was downregulated and FGFR3 was upregulated in lung cancer patients; We demonstrated that the overexpression of miR-99b induced a reduction in FGFR3 expression and confirmed the target specificity between miR-99b and the FGFR3 3'-untranslated region by luciferase reporter assay; Taken together these results suggest that miR-99b may be a tumor suppressor through the downregulation of FGFR3 miR-99b may be a potent tumor suppressor and may be a potential therapeutic tool for patients with lung cancer lung squamous cell cancer hsa-miR-149-5p FLNA 0.443278770827687 0.0642022866136881 0.947112590683666 4.10779218943303e-11 miRNAWalker2_validate -0.193288206448008 9.91458613742898e-14 NA NA NA hsa-miR-200c-3p FLNA 0.630251054099546 0.000131975031451555 0.947112590683666 4.10779218943303e-11 miRNAWalker2_validate -0.123643796665393 0.00129609742511502 NA NA NA hsa-miR-20a-5p FLNA 1.1531986665452 1.02385132917958e-11 0.947112590683666 4.10779218943303e-11 miRNAWalker2_validate -0.166071403154824 5.82686500812721e-06 NA NA NA hsa-miR-23b-3p FLNA -0.497563803223134 3.31483353357535e-05 0.947112590683666 4.10779218943303e-11 miRNAWalker2_validate -0.219502723011033 3.27096444342722e-05 24443580 Kaplan-Meier and multivariate analysis showed a significant association with tumour relapses for miR-23b and with tumour-specific death for miR-150 in PD and oPD thyroid carcinomas thyroid cancer hsa-miR-378a-3p FLNA -1.50453783521372 9.41694954361173e-17 0.947112590683666 4.10779218943303e-11 miRNAWalker2_validate -0.162485536640263 1.63036682652758e-06 NA NA NA hsa-miR-92a-3p FLNA 0.994679542307232 1.32587679156217e-16 0.947112590683666 4.10779218943303e-11 miRNAWalker2_validate -0.187866206849575 0.000264676215032243 NA NA NA hsa-miR-16-2-3p FLNB 1.1567130855258 1.01867256952189e-14 0.367505605988825 0.00532671883049422 mirMAP -0.111231537589613 0.00304900372459689 NA NA NA hsa-miR-195-3p FLNB -0.624259620429699 0.000164279659144497 0.367505605988825 0.00532671883049422 mirMAP -0.137073317127033 7.63535363886183e-05 NA NA NA hsa-miR-532-5p FLNB -0.021857649390892 0.830992272120134 0.367505605988825 0.00532671883049422 mirMAP -0.386487714058146 3.98654665651822e-12 NA NA NA hsa-miR-582-3p FLNB -0.248056267546012 0.143798829508405 0.367505605988825 0.00532671883049422 mirMAP -0.105092403460286 0.00195778953247607 NA NA NA hsa-miR-9-5p FLNB 1.65694862043766 2.08325802567323e-05 0.367505605988825 0.00532671883049422 miRNAWalker2_validate -0.118673706805248 6.99602366304683e-17 NA NA NA hsa-miR-92a-3p FLNB 0.994679542307232 1.32587679156217e-16 0.367505605988825 0.00532671883049422 miRNAWalker2_validate -0.149446927021999 0.00133868990921592 NA NA NA hsa-miR-142-3p FLNC 1.12754191614028 1.68798138028946e-08 -1.71802993904208 9.07819243555977e-06 miRanda -0.461811719741876 2.67635398445525e-08 NA NA NA hsa-miR-19a-3p FLNC 1.35800152353624 2.80940447111944e-12 -1.71802993904208 9.07819243555977e-06 miRNATAP -0.489302432601561 7.38893142311994e-09 NA NA NA hsa-miR-19b-3p FLNC 0.538732279378089 0.000622008277870679 -1.71802993904208 9.07819243555977e-06 miRNATAP -0.607489927867179 1.19094555036017e-08 NA NA NA hsa-miR-320a FLNC 0.801356001806321 4.91397101474502e-09 -1.71802993904208 9.07819243555977e-06 PITA;miRanda;miRNATAP -0.544616546045914 8.17316578095705e-06 NA NA NA hsa-miR-320b FLNC 1.23473838180754 3.04337566045537e-14 -1.71802993904208 9.07819243555977e-06 PITA;miRanda;miRNATAP -0.641078568217636 1.83709125351465e-10 NA NA NA hsa-miR-330-5p FLNC 0.944693925383906 5.04972895657346e-13 -1.71802993904208 9.07819243555977e-06 miRanda -0.392742628779094 0.00207153825440707 NA NA NA hsa-miR-342-3p FLNC 0.99756868977753 9.28499866272332e-10 -1.71802993904208 9.07819243555977e-06 miRanda;miRNATAP -0.450532897113455 1.06092846211082e-05 NA NA NA hsa-miR-454-3p FLNC 1.54137391927201 4.15861570449376e-20 -1.71802993904208 9.07819243555977e-06 miRNAWalker2_validate -0.55606628110653 8.31265025852894e-09 NA NA NA hsa-miR-181a-5p FOS 0.819060835827404 1.38616688310277e-13 -1.94423725327751 3.36208860239677e-15 miRNAWalker2_validate;miRTarBase;miRNATAP -0.274872801400247 0.00511956545283254 NA NA NA hsa-miR-181b-5p FOS 0.974255518824355 2.64876280203475e-16 -1.94423725327751 3.36208860239677e-15 miRNATAP -0.273287281120582 0.00257555350634645 NA NA NA hsa-miR-28-3p FOS 0.459875450032895 3.47095927872566e-07 -1.94423725327751 3.36208860239677e-15 MirTarget;PITA;miRNATAP -0.365627245752112 0.00288837798368387 NA NA NA hsa-miR-589-3p FOS 1.59559692667315 6.2886410639161e-15 -1.94423725327751 3.36208860239677e-15 MirTarget -0.145187612797684 0.0081138830630564 NA NA NA hsa-miR-148a-3p GADD45A -0.428944290834563 0.00954246923521465 -0.148778543104967 0.244563831657349 MirTarget;miRNATAP -0.115529771802971 0.000569454583886927 NA NA NA hsa-miR-148b-3p GADD45A 0.386859166050437 4.6728211830726e-06 -0.148778543104967 0.244563831657349 MirTarget -0.297536185776573 6.20121677211309e-06 NA NA NA hsa-miR-152-3p GADD45A -0.382486223604156 0.00710736505198702 -0.148778543104967 0.244563831657349 MirTarget -0.124908349912319 0.00141434525214503 NA NA NA hsa-miR-1976 GADD45B 0.638808083289405 2.94840228896364e-07 -1.29500058031274 1.88372965534317e-17 miRNATAP -0.163735681565526 0.00273735021269302 NA NA NA hsa-miR-324-3p GADD45B 0.867391246413545 3.63808540490361e-10 -1.29500058031274 1.88372965534317e-17 MirTarget;miRNATAP -0.456604551243598 2.13998090154516e-22 NA NA NA hsa-miR-590-3p GADD45B 0.221436901462551 0.0965904764063157 -1.29500058031274 1.88372965534317e-17 miRanda -0.163308519334935 0.00155213230880389 NA NA NA hsa-miR-107 GADD45G -0.0447040564279497 0.671618791096755 -1.08524974570121 1.91330427119552e-06 miRanda -0.261360902067525 0.00649010053220016 NA NA NA hsa-miR-320b GADD45G 1.23473838180754 3.04337566045537e-14 -1.08524974570121 1.91330427119552e-06 miRanda -0.177971631376559 0.00309864212413347 NA NA NA hsa-miR-421 GADD45G 0.945488088619653 2.35762398527362e-09 -1.08524974570121 1.91330427119552e-06 miRanda -0.165999925954088 0.00807659341669784 NA NA NA hsa-miR-141-3p GNA12 0.730011517758706 0.000120338355004032 1.36704302693302 1.32194215858346e-32 mirMAP -0.126995432250531 4.89313835212141e-06 NA NA NA hsa-miR-149-5p GNA12 0.443278770827687 0.0642022866136881 1.36704302693302 1.32194215858346e-32 miRNAWalker2_validate -0.103762581485947 2.68388652772559e-06 NA NA NA hsa-miR-181c-5p GNA12 -0.168991199007857 0.196949106150297 1.36704302693302 1.32194215858346e-32 mirMAP -0.15886680833657 9.90553701540662e-05 NA NA NA hsa-miR-195-5p GNA12 -1.8367376818177 6.9944883988895e-31 1.36704302693302 1.32194215858346e-32 MirTarget -0.138264030332034 1.11654639087251e-05 NA NA NA hsa-miR-200a-3p GNA12 0.607140814457753 0.00289840524858752 1.36704302693302 1.32194215858346e-32 mirMAP -0.161380037404649 3.48561535943158e-10 NA NA NA hsa-miR-23b-3p GNA12 -0.497563803223134 3.31483353357535e-05 1.36704302693302 1.32194215858346e-32 miRNAWalker2_validate -0.197592261839166 7.87308219431862e-06 NA NA NA hsa-miR-3065-3p GNA12 -0.543069092777161 0.0213164885178151 1.36704302693302 1.32194215858346e-32 mirMAP -0.107531334664755 1.6144709246422e-06 NA NA NA hsa-miR-30a-3p GNA12 -2.26144364746452 8.12421214153823e-31 1.36704302693302 1.32194215858346e-32 MirTarget -0.125050936832985 8.8356792156083e-07 NA NA NA hsa-miR-30d-3p GNA12 -0.577371911152798 2.02950840095287e-06 1.36704302693302 1.32194215858346e-32 MirTarget -0.34146523320375 1.24174220362941e-15 NA NA NA hsa-miR-30e-3p GNA12 -0.890635378639789 1.65740480611339e-16 1.36704302693302 1.32194215858346e-32 MirTarget -0.292457820929444 7.96511019137629e-10 NA NA NA hsa-miR-335-5p GNA12 -1.17227779671552 1.49282618530733e-10 1.36704302693302 1.32194215858346e-32 mirMAP -0.162170127972582 1.03058475544805e-08 NA NA NA hsa-miR-497-5p GNA12 -0.966244470847844 5.26505649147857e-12 1.36704302693302 1.32194215858346e-32 MirTarget -0.216983467942105 4.32120186751498e-09 NA NA NA hsa-miR-140-5p GNG12 -0.412389003031485 0.000136051708543369 -0.229202139720909 0.0250475379704555 PITA;miRanda -0.134715839462402 0.0010850909223448 NA NA NA hsa-miR-28-5p GNG12 -0.026996999089909 0.733047113251652 -0.229202139720909 0.0250475379704555 PITA;miRanda -0.240049752558578 2.59100377532133e-05 NA NA NA hsa-miR-30d-3p GNG12 -0.577371911152798 2.02950840095287e-06 -0.229202139720909 0.0250475379704555 mirMAP -0.218992490146666 1.26213229239791e-09 NA NA NA hsa-miR-374a-5p GNG12 -0.621903385111545 6.61791773205282e-12 -0.229202139720909 0.0250475379704555 mirMAP -0.142652973262067 0.00340230327070474 NA NA NA hsa-miR-374b-5p GNG12 -0.288413933608091 0.0041474558664058 -0.229202139720909 0.0250475379704555 mirMAP -0.335371886812206 1.24401033850306e-14 NA NA NA hsa-miR-409-5p GNG12 0.491285368786351 0.0165413843067426 -0.229202139720909 0.0250475379704555 PITA -0.112255441775039 1.86101629997431e-07 NA NA NA hsa-miR-423-5p GNG12 0.60141781325829 1.62940950644999e-07 -0.229202139720909 0.0250475379704555 miRNAWalker2_validate -0.15452866245864 5.76708984314237e-05 NA NA NA hsa-miR-590-3p GNG12 0.221436901462551 0.0965904764063157 -0.229202139720909 0.0250475379704555 miRanda;mirMAP -0.109436768392884 0.00108913938845348 NA NA NA hsa-miR-590-5p GNG12 0.763025362395968 3.65305892505623e-09 -0.229202139720909 0.0250475379704555 PITA -0.162980782845926 1.42844920041051e-06 NA NA NA hsa-miR-96-5p GNG12 1.42326703011157 4.39736150032373e-14 -0.229202139720909 0.0250475379704555 TargetScan -0.119950329982978 1.45488060901013e-07 NA NA NA hsa-let-7a-5p HRAS -0.439381775414001 3.1119785480023e-05 0.26280245681614 0.0556242904507885 miRNAWalker2_validate;miRTarBase -0.301645525492195 8.02100955354543e-08 20607356;23134218;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer; Overexpression of let-7a can inhibit the growth of lung cancer transplanted subcutaneously in nude mice by suppression of k-Ras and c-Myc;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;;;;progression glioblastoma;lung squamous cell cancer;lung cancer;lung cancer;pancreatic cancer hsa-let-7b-5p HRAS -0.2489842756826 0.0211384499461719 0.26280245681614 0.0556242904507885 miRTarBase -0.216577181164546 9.6758212516064e-05 20607356;20881268;18344688;20033209;19323605 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells;On the basis of these data we suggest that the downregulation of let-7b and let-7e targeting K-ras and the upregulation of miR-17* a CRC marker could be considered as candidate molecular markers of cetuximab resistance;Using an established orthotopic mouse lung cancer model we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene;k-Ras and c-Myc two key oncogenes in lung cancer have been found to be targeted by let-7 in vitro; The aim of the present study is to determine the effect of let-7a a member of let-7 family on the growth of lung cancer in vivo and to investigate whether let-7-induced suppression of k-Ras and c-Myc is involved in lung cancer;Because let-7 microRNA targets the K-ras oncogene we aimed to characterize let-7 expression and function in PDAC in vitro and in vivo; Restoring let-7 levels in cancer-derived cell lines strongly inhibits cell proliferation K-ras expression and mitogen-activated protein kinase activation but fails to impede tumor growth progression after intratumoral gene transfer or after implantation of Capan-1 cells stably overexpressing let-7 microRNA ;drug resistance;;;progression glioblastoma;colorectal cancer;lung cancer;lung cancer;pancreatic cancer hsa-miR-143-3p HRAS -1.33760181792708 4.15335119989612e-12 0.26280245681614 0.0556242904507885 miRNAWalker2_validate;miRTarBase -0.249594509349032 2.27678793354297e-17 21276449 The Evi1 microRNA 143 K Ras axis in colon cancer colon cancer hsa-miR-181d-5p HRAS 0.367649966373544 0.00537300571455306 0.26280245681614 0.0556242904507885 miRNAWalker2_validate;miRTarBase -0.122856153096347 0.00677992276763114 NA NA NA hsa-miR-125a-5p HSPA1A 0.215366061934933 0.119550904549401 -0.225217909408428 0.158621861360515 miRanda -0.131332572784366 0.00928925903637449 NA NA NA hsa-miR-193b-3p HSPA1L 1.72788400801602 3.0722151264559e-21 -0.546567594756171 1.25989478797777e-06 miRNAWalker2_validate -0.138624874176531 7.78367773425478e-08 NA NA NA hsa-miR-192-5p HSPA2 0.380924502586635 0.00986961967409205 0.424319372866884 0.0842255479698425 miRNAWalker2_validate -0.280932640356129 0.000103671247614054 NA NA NA hsa-miR-217 HSPA2 -1.35391381055929 2.42394951427902e-09 0.424319372866884 0.0842255479698425 miRanda -0.169939987896652 0.000243617472386825 NA NA NA hsa-miR-339-5p HSPA2 1.07771430326938 2.45772601859307e-09 0.424319372866884 0.0842255479698425 miRanda -0.158958233088733 0.00650854410549121 NA NA NA hsa-miR-500a-3p HSPA2 0.457959128173392 0.000691656736597067 0.424319372866884 0.0842255479698425 miRNATAP -0.224899899269071 0.00458068462664675 NA NA NA hsa-miR-7-1-3p HSPA2 1.13646121619622 1.49823237535933e-14 0.424319372866884 0.0842255479698425 mirMAP -0.229677718272153 0.00114950334117457 NA NA NA hsa-miR-130b-5p HSPA8 1.77265255049999 1.43627774829684e-29 -0.229378760517056 0.0184748503113762 miRNAWalker2_validate -0.11927524859834 2.51692804988619e-06 NA NA NA hsa-miR-15b-5p HSPA8 0.85315666454713 3.79816274836297e-12 -0.229378760517056 0.0184748503113762 miRNAWalker2_validate -0.133554122145776 7.81216751356583e-05 NA NA NA hsa-miR-25-3p HSPA8 0.76549796417801 3.32282098247097e-11 -0.229378760517056 0.0184748503113762 miRNAWalker2_validate -0.162203002173622 6.67877310275573e-06 NA NA NA hsa-miR-125a-3p IKBKB 0.116035800853173 0.444825559956959 -0.396740795566287 2.1815201064403e-05 miRanda -0.108503103251697 5.57509033653017e-05 NA NA NA hsa-miR-151a-3p IKBKB 0.131002217498676 0.295273522160941 -0.396740795566287 2.1815201064403e-05 miRNAWalker2_validate -0.104928278750609 0.00139735412928447 NA NA NA hsa-miR-542-3p IKBKB 0.643308814904977 8.81635403230104e-07 -0.396740795566287 2.1815201064403e-05 miRanda -0.164952079150207 8.30758678680247e-08 NA NA NA hsa-miR-107 IKBKG -0.0447040564279497 0.671618791096755 0.570547337190534 1.55778741154943e-10 miRanda -0.193473702960341 2.35749871093699e-07 NA NA NA hsa-miR-143-3p IKBKG -1.33760181792708 4.15335119989612e-12 0.570547337190534 1.55778741154943e-10 mirMAP -0.136024640433278 4.28001868046101e-12 NA NA NA hsa-miR-338-5p IKBKG -1.71946558699173 2.62649071488641e-23 0.570547337190534 1.55778741154943e-10 mirMAP -0.122404174241048 1.41142850944174e-08 NA NA NA hsa-miR-140-5p IL1A -0.412389003031485 0.000136051708543369 2.00781280937654 2.39057383153864e-08 miRanda -0.463443253369586 0.00164689764755682 NA NA NA hsa-miR-181c-5p IL1A -0.168991199007857 0.196949106150297 2.00781280937654 2.39057383153864e-08 MirTarget -0.782886423215508 6.75756008155393e-11 NA NA NA hsa-miR-181d-5p IL1A 0.367649966373544 0.00537300571455306 2.00781280937654 2.39057383153864e-08 MirTarget -0.560619915059391 2.86075725406214e-06 NA NA NA hsa-miR-30a-5p IL1A -1.79779915425811 1.93360169837799e-26 2.00781280937654 2.39057383153864e-08 MirTarget -0.539003354188258 9.90088532260576e-10 NA NA NA hsa-miR-30b-5p IL1A -0.400238605368173 0.00346540992719245 2.00781280937654 2.39057383153864e-08 MirTarget -0.427928657146442 0.000221837776414958 NA NA NA hsa-miR-30d-5p IL1A -0.38399848121878 0.000171129616944749 2.00781280937654 2.39057383153864e-08 MirTarget -0.87176581079203 1.63368954450137e-08 NA NA NA hsa-miR-30e-5p IL1A -1.02114836019762 6.81961221797866e-17 2.00781280937654 2.39057383153864e-08 MirTarget -0.773246098522638 5.73332426287182e-10 NA NA NA hsa-miR-335-5p IL1A -1.17227779671552 1.49282618530733e-10 2.00781280937654 2.39057383153864e-08 miRNAWalker2_validate -0.510440454529664 1.33927056615795e-09 NA NA NA hsa-miR-493-5p IL1A -0.471586962917071 0.0221327433064002 2.00781280937654 2.39057383153864e-08 MirTarget -0.255026715020076 0.000936161326846365 NA NA NA hsa-miR-532-5p IL1A -0.021857649390892 0.830992272120134 2.00781280937654 2.39057383153864e-08 MirTarget -0.725499738545333 3.22575781197608e-06 NA NA NA hsa-miR-664a-3p IL1A -0.256108763664991 0.0513188660751664 2.00781280937654 2.39057383153864e-08 MirTarget -0.513123540284563 2.16945611283765e-05 NA NA NA hsa-miR-30a-3p IL1B -2.26144364746452 8.12421214153823e-31 0.985214888218113 0.000346207862322016 MirTarget -0.229852864730208 6.79100302627562e-05 NA NA NA hsa-miR-30e-3p IL1B -0.890635378639789 1.65740480611339e-16 0.985214888218113 0.000346207862322016 MirTarget -0.357623602024864 0.00102451793076387 NA NA NA hsa-miR-495-3p IL1B -1.47803501311999 6.88839745293927e-13 0.985214888218113 0.000346207862322016 MirTarget -0.268600495864042 2.48090523925614e-06 NA NA NA hsa-miR-130b-5p IL1R1 1.77265255049999 1.43627774829684e-29 -0.258477920400496 0.0877609962203384 mirMAP -0.139670672212031 0.000421618347532264 NA NA NA hsa-miR-17-3p IL1R1 -0.0127974722290336 0.909559935689875 -0.258477920400496 0.0877609962203384 mirMAP -0.461807121039164 9.08394287544504e-16 NA NA NA hsa-miR-186-5p IL1R1 0.353452958261612 0.000145058448579496 -0.258477920400496 0.0877609962203384 mirMAP -0.386553072720816 4.29792380331471e-08 NA NA NA hsa-miR-192-5p IL1R1 0.380924502586635 0.00986961967409205 -0.258477920400496 0.0877609962203384 miRNAWalker2_validate -0.161167488746724 0.000301106587755486 NA NA NA hsa-miR-197-3p IL1R1 0.878693269130833 3.84847526014135e-15 -0.258477920400496 0.0877609962203384 miRNAWalker2_validate -0.205631080664336 0.000358047432482296 NA NA NA hsa-miR-26b-5p IL1R1 -0.254478038884324 0.0285227763044636 -0.258477920400496 0.0877609962203384 mirMAP -0.274490276032267 1.25081787637527e-06 NA NA NA hsa-miR-30d-3p IL1R1 -0.577371911152798 2.02950840095287e-06 -0.258477920400496 0.0877609962203384 mirMAP -0.351357852961884 4.10939728424481e-11 NA NA NA hsa-miR-335-3p IL1R1 0.336785882180547 0.0542446207938138 -0.258477920400496 0.0877609962203384 mirMAP -0.174812331888298 3.05441157376742e-06 NA NA NA hsa-miR-361-5p IL1R1 0.0803683277369505 0.314043140368058 -0.258477920400496 0.0877609962203384 miRanda -0.277211246579818 0.000964849416429579 NA NA NA hsa-miR-590-3p IL1R1 0.221436901462551 0.0965904764063157 -0.258477920400496 0.0877609962203384 miRanda;miRNATAP -0.210628181729486 2.03716482577516e-05 NA NA NA hsa-miR-330-5p JMJD7-PLA2G4B 0.944693925383906 5.04972895657346e-13 -0.796367559924462 7.52402910355677e-07 miRNATAP -0.189036602989866 0.000362977794134276 NA NA NA hsa-miR-542-3p JMJD7-PLA2G4B 0.643308814904977 8.81635403230104e-07 -0.796367559924462 7.52402910355677e-07 miRNATAP -0.316324839983911 2.59499534311272e-09 NA NA NA hsa-miR-149-5p JUN 0.443278770827687 0.0642022866136881 -0.406452458333556 0.00529454262070968 miRNAWalker2_validate;miRNATAP -0.13798147635329 1.52011589067818e-07 NA NA NA hsa-miR-16-5p JUN 0.521122945828175 1.40561786410572e-06 -0.406452458333556 0.00529454262070968 miRNAWalker2_validate -0.156896269424296 0.00762361936521659 NA NA NA hsa-miR-200b-3p JUN 0.0717138787925347 0.682858087587209 -0.406452458333556 0.00529454262070968 MirTarget;TargetScan -0.1505246140756 3.14972638592719e-05 NA NA NA hsa-miR-200c-3p JUN 0.630251054099546 0.000131975031451555 -0.406452458333556 0.00529454262070968 MirTarget -0.149132086953986 9.85741819973546e-05 NA NA NA hsa-miR-3917 JUN 0.881206418103063 1.02921825829718e-05 -0.406452458333556 0.00529454262070968 MirTarget -0.138885380502224 2.55553984021909e-05 NA NA NA hsa-miR-429 JUN 0.559451508722375 0.00563641638673083 -0.406452458333556 0.00529454262070968 MirTarget;PITA;miRanda;miRNATAP -0.127337260989549 4.67151021689913e-05 NA NA NA hsa-miR-92a-3p JUN 0.994679542307232 1.32587679156217e-16 -0.406452458333556 0.00529454262070968 miRNATAP -0.22222740352937 1.47904297910557e-05 NA NA NA hsa-miR-93-5p JUN 1.61042951896619 5.1280369606967e-24 -0.406452458333556 0.00529454262070968 miRNAWalker2_validate -0.163687155850785 1.63570130702134e-05 NA NA NA hsa-miR-940 JUN 1.25303020594374 1.3005368359451e-10 -0.406452458333556 0.00529454262070968 MirTarget;PITA;miRNATAP -0.11176871246434 0.000559179228679763 NA NA NA hsa-let-7a-3p KRAS 0.0966652362351867 0.423761916840503 -0.0421192166497262 0.67210141138451 mirMAP;miRNATAP -0.136931356508913 0.000135436448739821 24727325;20603437;24890702;23324806;21994416;23167843;27620744;20177422;25183481;22584434;18922928 Association study of the let 7 miRNA complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer NCCTG N0147 Clinical Trial; A let-7 microRNA-complementary site LCS6 polymorphism in the 3' untranslated region of the KRAS gene has been shown to disrupt let-7 binding and upregulate KRAS expression;A let 7 microRNA binding site polymorphism in 3' untranslated region of KRAS gene predicts response in wild type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy; A polymorphism in a let-7 microRNA complementary site lcs6 in the KRAS 3' untranslated region UTR is associated with an increased cancer risk in non-small-cell lung cancer and reduced overall survival OS in oral cancers; the presence of KRAS let-7 lcs6 polymorphism was evaluated in 130 mCRC patients who were enrolled in a phase II study of cetuximab monotherapy IMCL-0144; KRAS let-7 lcs6 polymorphism was found to be related to object response rate ORR in mCRC patients whose tumors had KRASwt;Let 7 microRNA binding site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta analysis; There is a small but growing body of literature regarding the predictive utility of a Let-7 microRNA-binding-site polymorphism in the 3'-untranslated region UTR of KRAS KRAS-LCS6 for colorectal cancer outcome although the results are conflicting; A PubMed search was conducted to identify all studies reporting on KRAS let-7 microRNA-binding site polymorphism LCS6; rs61764370 and colorectal cancer outcome;The LCS6 polymorphism in the binding site of let 7 microRNA to the KRAS 3' untranslated region: its role in the efficacy of anti EGFR based therapy in metastatic colorectal cancer patients; The lethal-7 let-7 family of microRNAs regulates KRAS activity; We studied the association of the KRAS let-7 LCS6 polymorphism with the response in 100 refractory mCRC patients treated with anti-EGFR antibodies; The KRAS let-7 LCS6 polymorphism was genotyped using the BioMark system in blood and tumor DNA samples; The KRAS let-7 LCS6 G-allele showed a statistically significant association with nonresponse to anti-EGFR-based treatment: 31.9% of patients with the T/T genotype presented a complete or a partial response versus no patients with T/G or G/G genotypes P=0.004;A let 7 microRNA SNP in the KRAS 3'UTR is prognostic in early stage colorectal cancer; Recently a SNP in a lethal-7 let-7 miRNA complementary site LCS6 in the KRAS 3'untranslated region was suggested to affect survival in metastatic CRC;Let 7 miRNA binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5 fluorouracil and oxaliplatin +/ cetuximab; Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site LCS6 within the 3'untranslated region 3'UTR of KRAS rs61764370 and clinical outcome in metastatic colorectal cancer mCRC patients receiving cetuximab;A let 7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population; The let-7 microRNAs play a key role in regulating KRAS expression and a polymorphism in 3' untranslated region rs61764370 T/G of KRAS leads to its higher expression;Genetic modulation of the Let 7 microRNA binding to KRAS 3' untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab irinotecan; There is increasing evidence that the Let-7 microRNA miRNA exerts an effect as a tumor suppressor by targeting the KRAS mRNA; The Let-7 complementary site LCS6 T>G variant in the KRAS 3'-untranslated region weakens Let-7 binding;A let 7 microRNA binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy;High let 7a microRNA levels in KRAS mutated colorectal carcinomas may rescue anti EGFR therapy effects in patients with chemotherapy refractory metastatic disease; Preclinical and experimental data in vivo indicate that Lethal-7 Let-7 microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations; In 59 patients harboring KRAS mutations Let-7a levels were analyzed for association with overall survival OS and progression-free survival PFS times; An exploratory subgroup analysis was performed using the rs61764370 LCS6 T>G polymorphism that experimentally impairs Let-7 binding to KRAS mRNA; In patients with KRAS mutations Let-7a analysis may serve to identify subgroups of patients who may still benefit from EGFR inhibition and this may open up new perspectives for alternative treatment strategies;A SNP in a let 7 microRNA complementary site in the KRAS 3' untranslated region increases non small cell lung cancer risk; The purpose of this study was to identify single nucleotide polymorphisms SNP that could modify let-7 binding and to assess the effect of such SNPs on target gene regulation and risk for non-small cell lung cancer NSCLC let-7 complementary sites LCS were sequenced in the KRAS 3' untranslated region from 74 NSCLC cases to identify mutations and SNPs that correlated with NSCLC; The LCS6 variant allele in a KRAS miRANA complementary site is significantly associated with increased risk for NSCLC among moderate smokers and represents a new paradigm for let-7 miRNAs in lung cancer susceptibility staging;drug resistance;poor survival;;drug resistance;staging;poor survival;;poor survival;poor survival;;progression;poor survival; colon cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;colorectal cancer;bladder cancer;colorectal cancer;colorectal cancer;colorectal cancer;lung squamous cell cancer hsa-miR-126-3p KRAS 0.0487843863772834 0.730130847436008 -0.0421192166497262 0.67210141138451 miRNAWalker2_validate;miRTarBase -0.115990819317181 0.0001500081257996 22845403 miR-126 is also known to target other crucial oncogenes in PDAC such as KRAS and CRK pancreatic cancer hsa-miR-155-5p KRAS 0.533437622040649 0.00248671179205372 -0.0421192166497262 0.67210141138451 miRNAWalker2_validate;miRNATAP -0.106787251340147 1.12687232356945e-05 NA NA NA hsa-miR-181a-5p KRAS 0.819060835827404 1.38616688310277e-13 -0.0421192166497262 0.67210141138451 miRNAWalker2_validate -0.206488916827338 5.30264645500736e-08 24098024;27517749;26124189 The KRAS mutational status was determined by pyrosequencing and miR-181a expression was measured by quantitative RT-PCR in CRC tumour tissue and corresponding non-neoplastic colon tissue;Here we report that miR-181a directly binds to 3'-untranslated regions UTRs; downregulates KRAS NRAS and MAPK1; and decreases AML growth; The delivery of miR-181a mimics to target AML cells using transferrin-targeting lipopolyplex nanoparticles NP increased mature miR-181a; downregulated KRAS NRAS and MAPK1; and resulted in decreased phosphorylation of the downstream RAS effectors;MiR 181a 5p inhibits cell proliferation and migration by targeting Kras in non small cell lung cancer A549 cells; Luciferase activity assay results demonstrated that two binding sites of Kras could be directly targeted by miR-181a-5p; Furthermore Kras was down-regulated by miR-181a-5p at both transcriptional and translational levels; SiRNA-mediated Kras down-regulation could mimic the effects of miR-181a-5p mimic in A549 cells; Our findings suggest that miR-181a-5p plays a potential role in tumor suppression by partially targeting Kras and has the potential therapeutic application in NSCLC patients ;; colorectal cancer;acute myeloid leukemia;lung squamous cell cancer hsa-miR-186-5p KRAS 0.353452958261612 0.000145058448579496 -0.0421192166497262 0.67210141138451 mirMAP -0.20957782293178 6.43868544074746e-06 NA NA NA hsa-miR-30a-5p KRAS -1.79779915425811 1.93360169837799e-26 -0.0421192166497262 0.67210141138451 mirMAP;miRNATAP -0.109380981252874 6.01372957790632e-06 NA NA NA hsa-miR-30b-5p KRAS -0.400238605368173 0.00346540992719245 -0.0421192166497262 0.67210141138451 mirMAP;miRNATAP -0.14630304008033 3.12182870258392e-06 NA NA NA hsa-miR-30c-5p KRAS 0.021222006155897 0.886366656528128 -0.0421192166497262 0.67210141138451 mirMAP;miRNATAP -0.160986192000454 2.5135861758379e-08 22701724 Deregulated miRNAs in hereditary breast cancer revealed a role for miR 30c in regulating KRAS oncogene; In particular we experimentally validated KRAS as a miR-30c target; Luciferase assays confirmed that miR-30c binds the 3'UTR of KRAS transcripts and expression of pre-miR-30c down-regulated KRAS mRNA and protein; In addition we provide evidence that KRAS is a target of miR-30c and that this miRNA suppresses breast cancer cell growth potentially through inhibition of KRAS signaling breast cancer hsa-miR-501-3p KRAS 0.820141346319976 1.74562930463389e-08 -0.0421192166497262 0.67210141138451 MirTarget;PITA;TargetScan;miRNATAP -0.107029284719557 0.000261941382230982 NA NA NA hsa-miR-542-3p KRAS 0.643308814904977 8.81635403230104e-07 -0.0421192166497262 0.67210141138451 miRanda -0.137689698022332 2.50585208964673e-05 NA NA NA hsa-miR-30c-5p MAP2K1 0.021222006155897 0.886366656528128 0.142764606305617 0.0590440739007102 miRNAWalker2_validate -0.10505314483532 1.85439886243956e-06 NA NA NA hsa-miR-34a-5p MAP2K1 -0.117372471043915 0.364001947180738 0.142764606305617 0.0590440739007102 miRNAWalker2_validate;miRTarBase -0.123625149360131 1.05490001381872e-06 NA NA NA hsa-let-7b-5p MAP2K2 -0.2489842756826 0.0211384499461719 -0.140639001206001 0.11730805163915 miRNAWalker2_validate -0.227132527741912 2.24643017568319e-10 NA NA NA hsa-miR-107 MAP2K3 -0.0447040564279497 0.671618791096755 -0.65760441156697 1.61904357360552e-11 miRNATAP -0.150742230947281 0.000267598795288844 NA NA NA hsa-miR-1271-5p MAP2K3 0.564681884899804 0.000425257395055278 -0.65760441156697 1.61904357360552e-11 MirTarget -0.112365472072931 2.85726904820858e-05 NA NA NA hsa-miR-15b-5p MAP2K3 0.85315666454713 3.79816274836297e-12 -0.65760441156697 1.61904357360552e-11 MirTarget;miRNATAP -0.16108857295904 2.91551078500552e-06 NA NA NA hsa-miR-16-5p MAP2K3 0.521122945828175 1.40561786410572e-06 -0.65760441156697 1.61904357360552e-11 MirTarget;miRNATAP -0.119784253389249 0.00273901707376053 NA NA NA hsa-miR-21-5p MAP2K3 1.62465922021121 3.44191300985109e-58 -0.65760441156697 1.61904357360552e-11 MirTarget -0.153730706316769 5.8948892638757e-05 24112539 The 3'-untranslated region 3'-UTR of MAP2K3 combined with miR-21 was experimentally verified by a miRNA luciferase reporter approach; More importantly the repression of MAP2K3 was inversely correlated with the expression of miR-21 in HCC; Further study demonstrated that the MAP2K3 was a novel direct target of miR-21 which was experimentally validated by a miRNA luciferase reporter approach; In HepG2 cells inhibition of miR-21 expression with an adenoviral miR-21 sponge vector profoundly suppressed cell proliferation by up-regulating MAP2K3 expression at both mRNA and protein levels; These results provide a clinical evidence that MAP2K3 may be a tumor repressor gene and it is a direct target of miR-21 in HCC indicating an underlying mechanism by which miR-21 is able to directly target MAP2K3 and inhibit its expression during the carcinogenesis of HCC at both transcriptional and post-translational levels tumorigenesis liver cancer hsa-miR-324-3p MAP2K3 0.867391246413545 3.63808540490361e-10 -0.65760441156697 1.61904357360552e-11 MirTarget -0.114233834597244 0.000205995607021255 NA NA NA hsa-miR-3913-5p MAP2K3 0.48532077857571 0.00112373589405304 -0.65760441156697 1.61904357360552e-11 MirTarget;miRNATAP -0.195800640146426 7.83991373771302e-12 NA NA NA hsa-miR-15b-5p MAP2K4 0.85315666454713 3.79816274836297e-12 -0.423467552984938 4.10366424025969e-07 miRNAWalker2_validate -0.184501045320164 1.82978939326219e-10 NA NA NA hsa-miR-25-3p MAP2K4 0.76549796417801 3.32282098247097e-11 -0.423467552984938 4.10366424025969e-07 miRNATAP -0.3176538609033 2.04542910258871e-26 NA NA NA hsa-miR-26a-2-3p MAP2K4 -0.444498687388748 0.00325793861409413 -0.423467552984938 4.10366424025969e-07 mirMAP -0.121937864537599 4.25433230124197e-07 NA NA NA hsa-miR-30c-5p MAP2K4 0.021222006155897 0.886366656528128 -0.423467552984938 4.10366424025969e-07 miRNATAP -0.107220112754578 1.40543941283221e-05 NA NA NA hsa-miR-30d-5p MAP2K4 -0.38399848121878 0.000171129616944749 -0.423467552984938 4.10366424025969e-07 miRNATAP -0.104446926249224 0.00376732309316896 NA NA NA hsa-miR-32-5p MAP2K4 -0.317310201890053 0.0102525324475293 -0.423467552984938 4.10366424025969e-07 miRNATAP -0.117930869973216 7.1237433306363e-05 NA NA NA hsa-miR-374a-3p MAP2K4 -0.299190081500425 0.00682975596757891 -0.423467552984938 4.10366424025969e-07 mirMAP -0.136412763947711 4.01945472369358e-05 NA NA NA hsa-miR-374b-5p MAP2K4 -0.288413933608091 0.0041474558664058 -0.423467552984938 4.10366424025969e-07 miRNATAP -0.212608557089606 4.63850433724873e-09 NA NA NA hsa-miR-532-3p MAP2K4 0.80240056676907 1.08989551712617e-09 -0.423467552984938 4.10366424025969e-07 miRNATAP -0.115067180055355 2.71559683269998e-05 NA NA NA hsa-miR-582-5p MAP2K4 -0.0366995972742474 0.821827119138923 -0.423467552984938 4.10366424025969e-07 PITA;miRNATAP -0.128327553894398 9.00035134505252e-09 NA NA NA hsa-miR-92a-3p MAP2K4 0.994679542307232 1.32587679156217e-16 -0.423467552984938 4.10366424025969e-07 miRNATAP -0.131294202156664 9.10796845910341e-06 NA NA NA hsa-miR-125a-3p MAP2K6 0.116035800853173 0.444825559956959 -1.30037325052009 4.75253531631099e-10 miRanda -0.208758395180322 0.0006275104731642 NA NA NA hsa-miR-193a-3p MAP2K6 0.22120710726779 0.111827069464729 -1.30037325052009 4.75253531631099e-10 miRanda -0.427602638746949 7.53415448988712e-11 NA NA NA hsa-miR-425-5p MAP2K6 0.931027421598738 6.46235724408844e-08 -1.30037325052009 4.75253531631099e-10 miRNAWalker2_validate;MirTarget -0.145817116606766 0.00606997788756328 NA NA NA hsa-let-7d-5p MAP3K1 0.481757661442508 3.66030810124939e-07 -0.680645203420506 5.30630702530132e-08 miRNATAP -0.19550799819126 0.000769790688950881 NA NA NA hsa-miR-125a-5p MAP3K1 0.215366061934933 0.119550904549401 -0.680645203420506 5.30630702530132e-08 miRNAWalker2_validate -0.235828899243037 2.33104522968163e-09 NA NA NA hsa-miR-17-5p MAP3K1 1.41924888736771 2.75805544953758e-18 -0.680645203420506 5.30630702530132e-08 TargetScan;miRNATAP -0.227025304251578 1.62496269777463e-12 NA NA NA hsa-miR-186-5p MAP3K1 0.353452958261612 0.000145058448579496 -0.680645203420506 5.30630702530132e-08 miRNATAP -0.251371039636476 2.28879710487271e-05 NA NA NA hsa-miR-18a-5p MAP3K1 1.65455873230328 3.76457892277775e-20 -0.680645203420506 5.30630702530132e-08 miRNATAP -0.24321568195589 1.96318157781272e-17 NA NA NA hsa-miR-19a-3p MAP3K1 1.35800152353624 2.80940447111944e-12 -0.680645203420506 5.30630702530132e-08 miRNATAP -0.205407234994842 3.65132568055492e-14 NA NA NA hsa-miR-19b-3p MAP3K1 0.538732279378089 0.000622008277870679 -0.680645203420506 5.30630702530132e-08 miRNATAP -0.219643483964009 1.72795913694471e-10 NA NA NA hsa-miR-20a-5p MAP3K1 1.1531986665452 1.02385132917958e-11 -0.680645203420506 5.30630702530132e-08 miRNATAP -0.200997829346476 1.5671117838e-10 NA NA NA hsa-miR-21-5p MAP3K1 1.62465922021121 3.44191300985109e-58 -0.680645203420506 5.30630702530132e-08 miRNAWalker2_validate -0.237300583671259 1.0246007621873e-06 NA NA NA hsa-miR-26b-5p MAP3K1 -0.254478038884324 0.0285227763044636 -0.680645203420506 5.30630702530132e-08 miRNATAP -0.161507307114465 0.000697608502764288 NA NA NA hsa-miR-30c-5p MAP3K1 0.021222006155897 0.886366656528128 -0.680645203420506 5.30630702530132e-08 miRNATAP -0.188945578451036 3.18467218510461e-07 NA NA NA hsa-miR-338-3p MAP3K1 -0.948755228846395 8.99167125682392e-08 -0.680645203420506 5.30630702530132e-08 miRanda -0.13253150540563 1.44921098743846e-05 NA NA NA hsa-miR-339-5p MAP3K1 1.07771430326938 2.45772601859307e-09 -0.680645203420506 5.30630702530132e-08 miRanda -0.226499458323676 1.17093507263991e-14 NA NA NA hsa-miR-34a-5p MAP3K1 -0.117372471043915 0.364001947180738 -0.680645203420506 5.30630702530132e-08 miRNAWalker2_validate -0.139157830128188 0.00115808314688296 NA NA NA hsa-miR-423-3p MAP3K1 1.20230884409188 2.57129723627633e-23 -0.680645203420506 5.30630702530132e-08 miRNAWalker2_validate -0.236166116759096 5.245577687157e-08 NA NA NA hsa-miR-501-5p MAP3K1 1.02806906860218 1.63456814370548e-09 -0.680645203420506 5.30630702530132e-08 PITA -0.181789846501427 1.25461460481523e-08 NA NA NA hsa-miR-590-5p MAP3K1 0.763025362395968 3.65305892505623e-09 -0.680645203420506 5.30630702530132e-08 PITA;miRanda;miRNATAP -0.218635281482478 1.67760581002581e-07 NA NA NA hsa-miR-93-5p MAP3K1 1.61042951896619 5.1280369606967e-24 -0.680645203420506 5.30630702530132e-08 miRNATAP -0.213220571637156 5.69907028717147e-11 NA NA NA hsa-miR-125b-5p MAP3K11 -0.993460109818276 5.07736727659894e-12 0.362723510942587 6.64930238537574e-06 miRNATAP -0.128159401492586 7.31974737604095e-08 24635082 Expression of the miRNA miR-125b and serine/threonine kinase mixed lineage kinase MLK3 was assessed in primary malignant melanoma tissues and several melanoma cell lines by quantitative reverse transcription PCR; The effect of MLK3 and miR-125b on cell proliferation was evaluated by MTS assay and cell invasion was evaluated by Transwell invasion assays; Targeting of MLK3 by miR-125b was evaluated using luciferase reporter assay and western blotting; Using bioinformatics we identified MLK3 as one potential target of miR-125b; miRNA transfection and luciferase assay confirmed that MLK3 was regulated by miR-125b at both the transcriptional and translational levels; MLK3 is a direct target of miR-125b malignant trasformation melanoma hsa-miR-378a-5p MAP3K11 -1.31095692407946 2.375328908085e-15 0.362723510942587 6.64930238537574e-06 miRNATAP -0.107660921087246 1.58608938413901e-07 NA NA NA hsa-miR-17-5p MAP3K12 1.41924888736771 2.75805544953758e-18 0.359014440909096 0.0124430360968829 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.16403893897515 9.48687910021055e-06 NA NA NA hsa-miR-19a-3p MAP3K12 1.35800152353624 2.80940447111944e-12 0.359014440909096 0.0124430360968829 MirTarget -0.127306432342173 5.0754426479153e-05 NA NA NA hsa-miR-19b-3p MAP3K12 0.538732279378089 0.000622008277870679 0.359014440909096 0.0124430360968829 MirTarget -0.158575994582815 6.07880402270031e-05 NA NA NA hsa-miR-20a-5p MAP3K12 1.1531986665452 1.02385132917958e-11 0.359014440909096 0.0124430360968829 miRNAWalker2_validate;miRTarBase;MirTarget -0.152039197128794 2.51002782812622e-05 NA NA NA hsa-miR-429 MAP3K12 0.559451508722375 0.00563641638673083 0.359014440909096 0.0124430360968829 miRNATAP -0.146839706842511 1.73459860196212e-06 NA NA NA hsa-let-7a-3p MAP3K13 0.0966652362351867 0.423761916840503 -0.275233697227031 0.183974658221674 mirMAP -0.331339812675328 9.28435940886031e-06 NA NA NA hsa-miR-139-5p MAP3K13 -1.46099200329485 7.85040381494472e-22 -0.275233697227031 0.183974658221674 miRanda -0.213596830754541 0.000170114324321966 NA NA NA hsa-miR-17-5p MAP3K13 1.41924888736771 2.75805544953758e-18 -0.275233697227031 0.183974658221674 miRNATAP -0.327186953283551 6.08678059379291e-10 NA NA NA hsa-miR-181a-5p MAP3K13 0.819060835827404 1.38616688310277e-13 -0.275233697227031 0.183974658221674 mirMAP -0.287450062547219 0.000319945219301698 NA NA NA hsa-miR-181b-5p MAP3K13 0.974255518824355 2.64876280203475e-16 -0.275233697227031 0.183974658221674 mirMAP -0.321898061581167 1.21613394305548e-05 NA NA NA hsa-miR-186-5p MAP3K13 0.353452958261612 0.000145058448579496 -0.275233697227031 0.183974658221674 mirMAP -0.443611291271965 4.77553590198778e-06 NA NA NA hsa-miR-188-5p MAP3K13 0.559328953885106 0.000430338888594543 -0.275233697227031 0.183974658221674 mirMAP -0.163693767170843 0.00399390299180423 NA NA NA hsa-miR-20a-3p MAP3K13 1.34885093664027 2.07697464119202e-12 -0.275233697227031 0.183974658221674 mirMAP -0.261942527899783 8.27359828743623e-09 NA NA NA hsa-miR-20a-5p MAP3K13 1.1531986665452 1.02385132917958e-11 -0.275233697227031 0.183974658221674 miRNATAP -0.328501559739884 1.63868283519475e-10 NA NA NA hsa-miR-22-5p MAP3K13 0.706731861922839 3.44318705980007e-07 -0.275233697227031 0.183974658221674 mirMAP -0.280933931138113 1.22383987599763e-05 NA NA NA hsa-miR-30b-5p MAP3K13 -0.400238605368173 0.00346540992719245 -0.275233697227031 0.183974658221674 MirTarget;mirMAP -0.198578343727608 0.00259087999353946 NA NA NA hsa-miR-30c-5p MAP3K13 0.021222006155897 0.886366656528128 -0.275233697227031 0.183974658221674 MirTarget;mirMAP;miRNATAP -0.297037060452982 9.22209125029477e-07 NA NA NA hsa-miR-320a MAP3K13 0.801356001806321 4.91397101474502e-09 -0.275233697227031 0.183974658221674 mirMAP -0.249369490387557 0.000122125674470367 NA NA NA hsa-miR-339-5p MAP3K13 1.07771430326938 2.45772601859307e-09 -0.275233697227031 0.183974658221674 miRanda -0.238859523126467 9.95663604030354e-07 NA NA NA hsa-miR-369-3p MAP3K13 -1.2344419076994 2.66882944171146e-10 -0.275233697227031 0.183974658221674 mirMAP;miRNATAP -0.156474327448487 0.000571493801496443 NA NA NA hsa-miR-374a-3p MAP3K13 -0.299190081500425 0.00682975596757891 -0.275233697227031 0.183974658221674 mirMAP -0.226265808728783 0.00579670317056111 NA NA NA hsa-miR-376c-3p MAP3K13 -1.70422793441579 1.16555506116207e-15 -0.275233697227031 0.183974658221674 mirMAP -0.111238259639074 0.00696868954773222 NA NA NA hsa-miR-450b-5p MAP3K13 1.25529820885833 1.18847120528666e-15 -0.275233697227031 0.183974658221674 MirTarget;PITA;mirMAP;miRNATAP -0.236057431787059 2.28527053249119e-05 NA NA NA hsa-miR-500a-5p MAP3K13 0.675401699376111 8.24389004707854e-05 -0.275233697227031 0.183974658221674 mirMAP -0.347001831107029 1.48167431175214e-11 NA NA NA hsa-miR-505-3p MAP3K13 0.912823669571645 4.0549774967148e-13 -0.275233697227031 0.183974658221674 mirMAP -0.267922189661471 0.000133359589141137 NA NA NA hsa-miR-542-3p MAP3K13 0.643308814904977 8.81635403230104e-07 -0.275233697227031 0.183974658221674 MirTarget -0.345357737162361 3.74244941829096e-07 NA NA NA hsa-miR-576-5p MAP3K13 0.940432050128373 6.90227595663302e-12 -0.275233697227031 0.183974658221674 MirTarget -0.360417567247908 1.73382872266916e-08 NA NA NA hsa-miR-589-3p MAP3K13 1.59559692667315 6.2886410639161e-15 -0.275233697227031 0.183974658221674 mirMAP -0.16830633423956 0.000159257700579971 NA NA NA hsa-miR-93-5p MAP3K13 1.61042951896619 5.1280369606967e-24 -0.275233697227031 0.183974658221674 miRNAWalker2_validate;miRNATAP -0.148987978647494 0.00593284015156682 NA NA NA hsa-miR-17-5p MAP3K14 1.41924888736771 2.75805544953758e-18 -0.820531706687164 8.24898608505683e-10 MirTarget -0.180703236855232 2.16010787102818e-07 NA NA NA hsa-miR-20a-5p MAP3K14 1.1531986665452 1.02385132917958e-11 -0.820531706687164 8.24898608505683e-10 MirTarget -0.122103687330653 0.000348942989232876 NA NA NA hsa-miR-542-3p MAP3K14 0.643308814904977 8.81635403230104e-07 -0.820531706687164 8.24898608505683e-10 miRanda -0.141071427870492 0.00167669092004037 27107696 miR 542 3p suppresses invasion and metastasis by targeting the proto oncogene serine/threonine protein kinase PIM1 in melanoma; The proto-oncogene serine/threonine protein kinase PIM1 was identified as a direct target of miR-542-3p using luciferase reporter assay qRT-PCR and western blot analyses metastasis melanoma hsa-miR-101-5p MAP3K2 -1.429324744941 4.00032662184937e-18 0.298189134827425 0.0186234500376514 mirMAP -0.101454687293007 0.00175570339799205 NA NA NA hsa-miR-10b-5p MAP3K2 -0.582989331935508 4.56688330655626e-06 0.298189134827425 0.0186234500376514 miRNATAP -0.256569747650253 1.83127325176685e-09 NA NA NA hsa-miR-139-5p MAP3K2 -1.46099200329485 7.85040381494472e-22 0.298189134827425 0.0186234500376514 miRanda;mirMAP -0.129042904170975 0.000207375122620489 NA NA NA hsa-miR-141-3p MAP3K2 0.730011517758706 0.000120338355004032 0.298189134827425 0.0186234500376514 MirTarget;TargetScan;miRNATAP -0.13228579214971 4.2185472810156e-06 NA NA NA hsa-miR-148b-5p MAP3K2 1.1533193737265 7.26420964688337e-13 0.298189134827425 0.0186234500376514 mirMAP -0.168715855586398 5.90344418441297e-07 NA NA NA hsa-miR-16-2-3p MAP3K2 1.1567130855258 1.01867256952189e-14 0.298189134827425 0.0186234500376514 mirMAP -0.178229300191941 6.21398871702225e-07 NA NA NA hsa-miR-17-5p MAP3K2 1.41924888736771 2.75805544953758e-18 0.298189134827425 0.0186234500376514 MirTarget;TargetScan;miRNATAP -0.201522630933908 4.73123033944394e-10 NA NA NA hsa-miR-186-5p MAP3K2 0.353452958261612 0.000145058448579496 0.298189134827425 0.0186234500376514 MirTarget;miRNATAP -0.303837013479353 2.87661286855784e-07 27498924 MicroRNA 186 suppresses cell proliferation and metastasis through targeting MAP3K2 in non small cell lung cancer; Furthermore we observed tthat the overexpression of MAP3K2 partially reversed the inhibitory effect of miR-186 on the proliferation and metastasis of A549 and HCC827 cell lines; Taken together our data indicated that miR-186 regulates lung cancer growth and metastasis through suppressing MAP3K2 expression at least partly metastasis lung squamous cell cancer hsa-miR-19a-3p MAP3K2 1.35800152353624 2.80940447111944e-12 0.298189134827425 0.0186234500376514 MirTarget;mirMAP;miRNATAP -0.243366756594642 1.26135271783903e-19 NA NA NA hsa-miR-19b-3p MAP3K2 0.538732279378089 0.000622008277870679 0.298189134827425 0.0186234500376514 MirTarget;mirMAP;miRNATAP -0.356118664592463 1.05092808653681e-26 NA NA NA hsa-miR-200a-3p MAP3K2 0.607140814457753 0.00289840524858752 0.298189134827425 0.0186234500376514 MirTarget;miRNATAP -0.110967708032087 3.6907959220517e-05 NA NA NA hsa-miR-20a-5p MAP3K2 1.1531986665452 1.02385132917958e-11 0.298189134827425 0.0186234500376514 MirTarget;miRNATAP -0.242943542241716 6.44186359991121e-15 NA NA NA hsa-miR-22-5p MAP3K2 0.706731861922839 3.44318705980007e-07 0.298189134827425 0.0186234500376514 MirTarget -0.150466073526009 0.000134504268293113 NA NA NA hsa-miR-26a-2-3p MAP3K2 -0.444498687388748 0.00325793861409413 0.298189134827425 0.0186234500376514 mirMAP -0.220888878185854 9.14984216200603e-10 NA NA NA hsa-miR-26b-5p MAP3K2 -0.254478038884324 0.0285227763044636 0.298189134827425 0.0186234500376514 mirMAP;miRNATAP -0.357991613259982 1.65920891685887e-14 NA NA NA hsa-miR-30a-5p MAP3K2 -1.79779915425811 1.93360169837799e-26 0.298189134827425 0.0186234500376514 mirMAP;miRNATAP -0.172921952049398 1.82932319212726e-08 NA NA NA hsa-miR-30b-5p MAP3K2 -0.400238605368173 0.00346540992719245 0.298189134827425 0.0186234500376514 mirMAP;miRNATAP -0.359612753394019 2.49115183374827e-20 NA NA NA hsa-miR-30c-5p MAP3K2 0.021222006155897 0.886366656528128 0.298189134827425 0.0186234500376514 mirMAP;miRNATAP -0.34658476244962 4.27850222808917e-22 NA NA NA hsa-miR-30d-3p MAP3K2 -0.577371911152798 2.02950840095287e-06 0.298189134827425 0.0186234500376514 MirTarget -0.295201304827345 3.57669515718683e-11 NA NA NA hsa-miR-30e-5p MAP3K2 -1.02114836019762 6.81961221797866e-17 0.298189134827425 0.0186234500376514 mirMAP -0.121425697287777 0.00577459118415468 NA NA NA hsa-miR-320a MAP3K2 0.801356001806321 4.91397101474502e-09 0.298189134827425 0.0186234500376514 miRanda;mirMAP -0.233519607268716 2.94732311887913e-09 NA NA NA hsa-miR-338-3p MAP3K2 -0.948755228846395 8.99167125682392e-08 0.298189134827425 0.0186234500376514 miRNATAP -0.289021149594157 1.23020564568438e-22 NA NA NA hsa-miR-342-3p MAP3K2 0.99756868977753 9.28499866272332e-10 0.298189134827425 0.0186234500376514 MirTarget;miRanda -0.244289740116966 7.15270380858188e-14 NA NA NA hsa-miR-3607-3p MAP3K2 1.01377165357363 9.13355519701165e-05 0.298189134827425 0.0186234500376514 MirTarget;miRNATAP -0.11038309235158 1.44009866608847e-07 NA NA NA hsa-miR-374b-5p MAP3K2 -0.288413933608091 0.0041474558664058 0.298189134827425 0.0186234500376514 MirTarget;miRNATAP -0.29937664745772 4.43084315077263e-08 NA NA NA hsa-miR-576-5p MAP3K2 0.940432050128373 6.90227595663302e-12 0.298189134827425 0.0186234500376514 mirMAP -0.213905999931231 4.76713175866717e-08 NA NA NA hsa-miR-582-5p MAP3K2 -0.0366995972742474 0.821827119138923 0.298189134827425 0.0186234500376514 mirMAP -0.19564070140273 5.62362046699162e-09 NA NA NA hsa-miR-590-3p MAP3K2 0.221436901462551 0.0965904764063157 0.298189134827425 0.0186234500376514 miRanda;miRNATAP -0.126493210375283 0.00235226659141342 NA NA NA hsa-miR-590-5p MAP3K2 0.763025362395968 3.65305892505623e-09 0.298189134827425 0.0186234500376514 mirMAP -0.203345684693225 1.23542354322553e-06 NA NA NA hsa-miR-664a-3p MAP3K2 -0.256108763664991 0.0513188660751664 0.298189134827425 0.0186234500376514 mirMAP -0.268240140648111 1.03481799661859e-10 NA NA NA hsa-miR-7-1-3p MAP3K2 1.13646121619622 1.49823237535933e-14 0.298189134827425 0.0186234500376514 MirTarget;mirMAP -0.112193952611373 0.00208160876995298 NA NA NA hsa-miR-93-5p MAP3K2 1.61042951896619 5.1280369606967e-24 0.298189134827425 0.0186234500376514 MirTarget;miRNATAP -0.180366724063543 3.78591797882918e-08 NA NA NA hsa-miR-96-5p MAP3K2 1.42326703011157 4.39736150032373e-14 0.298189134827425 0.0186234500376514 TargetScan -0.11477174509016 5.4794909095407e-05 NA NA NA hsa-miR-106b-5p MAP3K3 0.50378717276868 1.45412404526866e-05 -0.380400865148764 2.00538789400966e-05 MirTarget;miRNATAP -0.118737065729052 0.000390176417652698 NA NA NA hsa-miR-141-3p MAP3K3 0.730011517758706 0.000120338355004032 -0.380400865148764 2.00538789400966e-05 miRNATAP -0.255803814390387 5.7926723112848e-42 NA NA NA hsa-miR-15a-5p MAP3K3 0.783550182002274 2.60699595655907e-11 -0.380400865148764 2.00538789400966e-05 MirTarget;miRNATAP -0.232471532428084 4.25818334395765e-13 NA NA NA hsa-miR-17-5p MAP3K3 1.41924888736771 2.75805544953758e-18 -0.380400865148764 2.00538789400966e-05 MirTarget;TargetScan;miRNATAP -0.257288368129438 4.65612899507498e-32 NA NA NA hsa-miR-182-5p MAP3K3 1.15060905311096 6.25565852529946e-10 -0.380400865148764 2.00538789400966e-05 miRNATAP -0.183656985436204 2.77560713220215e-20 NA NA NA hsa-miR-193b-3p MAP3K3 1.72788400801602 3.0722151264559e-21 -0.380400865148764 2.00538789400966e-05 miRNAWalker2_validate;miRNATAP -0.124659506122166 7.36066344558362e-10 NA NA NA hsa-miR-200a-3p MAP3K3 0.607140814457753 0.00289840524858752 -0.380400865148764 2.00538789400966e-05 miRNATAP -0.216105315958897 1.49694326180692e-33 NA NA NA hsa-miR-20a-5p MAP3K3 1.1531986665452 1.02385132917958e-11 -0.380400865148764 2.00538789400966e-05 MirTarget;miRNATAP -0.240239817068566 2.51902178903543e-29 NA NA NA hsa-miR-2355-5p MAP3K3 1.47205546931107 8.65192179636668e-19 -0.380400865148764 2.00538789400966e-05 miRNATAP -0.145263673844882 7.5547330213925e-11 NA NA NA hsa-miR-33a-5p MAP3K3 1.12988965056352 3.35742517382153e-07 -0.380400865148764 2.00538789400966e-05 miRNATAP -0.120432480438125 1.79563546116848e-12 NA NA NA hsa-miR-429 MAP3K3 0.559451508722375 0.00563641638673083 -0.380400865148764 2.00538789400966e-05 miRNATAP -0.213389064928498 5.51535494791199e-32 NA NA NA hsa-miR-484 MAP3K3 0.918280909791707 1.39168306854263e-14 -0.380400865148764 2.00538789400966e-05 miRNATAP -0.12627344666982 7.63781313919229e-05 NA NA NA hsa-miR-505-3p MAP3K3 0.912823669571645 4.0549774967148e-13 -0.380400865148764 2.00538789400966e-05 miRNATAP -0.140072006446262 3.64589482408328e-06 NA NA NA hsa-miR-7-1-3p MAP3K3 1.13646121619622 1.49823237535933e-14 -0.380400865148764 2.00538789400966e-05 mirMAP -0.107106878696954 3.00426975268051e-05 NA NA NA hsa-miR-708-5p MAP3K3 1.54207894190626 2.2887257992285e-19 -0.380400865148764 2.00538789400966e-05 MirTarget;miRNATAP -0.157819161177373 2.17758623936782e-13 NA NA NA hsa-miR-93-5p MAP3K3 1.61042951896619 5.1280369606967e-24 -0.380400865148764 2.00538789400966e-05 MirTarget;miRNATAP -0.223173969605366 2.69128063402107e-23 NA NA NA hsa-miR-96-5p MAP3K3 1.42326703011157 4.39736150032373e-14 -0.380400865148764 2.00538789400966e-05 MirTarget;TargetScan;miRNATAP -0.212384612001346 1.19765181444708e-28 NA NA NA hsa-miR-16-5p MAP3K4 0.521122945828175 1.40561786410572e-06 -0.0763878181081594 0.361356682546704 miRNATAP -0.102022275835601 0.00233681251252623 NA NA NA hsa-miR-320a MAP3K4 0.801356001806321 4.91397101474502e-09 -0.0763878181081594 0.361356682546704 miRanda -0.130843616564453 4.77745733645623e-07 NA NA NA hsa-miR-320b MAP3K4 1.23473838180754 3.04337566045537e-14 -0.0763878181081594 0.361356682546704 miRanda -0.10664411315143 8.18754827701497e-07 NA NA NA hsa-miR-34a-5p MAP3K7 -0.117372471043915 0.364001947180738 0.156076953982623 0.0290717069126645 miRNAWalker2_validate -0.131051914210823 4.05863054241424e-08 NA NA NA hsa-miR-374a-5p MAP3K7 -0.621903385111545 6.61791773205282e-12 0.156076953982623 0.0290717069126645 mirMAP -0.108854397484665 0.00133067551793497 NA NA NA hsa-miR-374b-5p MAP3K7 -0.288413933608091 0.0041474558664058 0.156076953982623 0.0290717069126645 mirMAP -0.123352040948618 6.70833151697066e-05 NA NA NA hsa-miR-664a-3p MAP3K7 -0.256108763664991 0.0513188660751664 0.156076953982623 0.0290717069126645 MirTarget;mirMAP -0.124053258642684 1.26589173107656e-07 NA NA NA hsa-let-7a-2-3p MAP3K8 0.00246680275221167 0.991649532156321 -1.03790741763165 1.31111064157906e-11 MirTarget -0.118859303784253 5.18105322260668e-05 NA NA NA hsa-let-7a-3p MAP3K8 0.0966652362351867 0.423761916840503 -1.03790741763165 1.31111064157906e-11 MirTarget -0.157051155288088 0.00568911064078083 NA NA NA hsa-miR-17-5p MAP3K8 1.41924888736771 2.75805544953758e-18 -1.03790741763165 1.31111064157906e-11 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.150992872636533 0.000186851039122703 NA NA NA hsa-miR-181a-5p MAP3K8 0.819060835827404 1.38616688310277e-13 -1.03790741763165 1.31111064157906e-11 MirTarget -0.278955161065136 3.46736901044126e-06 NA NA NA hsa-miR-181b-5p MAP3K8 0.974255518824355 2.64876280203475e-16 -1.03790741763165 1.31111064157906e-11 MirTarget -0.420941300528388 1.18435559655957e-14 NA NA NA hsa-miR-181d-5p MAP3K8 0.367649966373544 0.00537300571455306 -1.03790741763165 1.31111064157906e-11 MirTarget -0.147180592764006 0.00442007890829577 NA NA NA hsa-miR-20a-5p MAP3K8 1.1531986665452 1.02385132917958e-11 -1.03790741763165 1.31111064157906e-11 MirTarget;miRNATAP -0.109310436947433 0.00558969463072235 NA NA NA hsa-miR-370-3p MAP3K8 -0.362239506850908 0.0857012995712968 -1.03790741763165 1.31111064157906e-11 miRNAWalker2_validate;miRTarBase;MirTarget -0.169743082070913 1.30085955196595e-07 NA NA NA hsa-miR-589-5p MAP3K8 0.807877250867909 4.12262850391353e-14 -1.03790741763165 1.31111064157906e-11 MirTarget;miRNATAP -0.189239836867069 0.00250144657155946 NA NA NA hsa-let-7a-3p MAP4K3 0.0966652362351867 0.423761916840503 -0.0832968976679487 0.368143524727499 mirMAP -0.121265348921275 0.00028139929135093 NA NA NA hsa-miR-155-5p MAP4K3 0.533437622040649 0.00248671179205372 -0.0832968976679487 0.368143524727499 MirTarget -0.139210223228112 5.21983593176919e-10 NA NA NA hsa-miR-186-5p MAP4K3 0.353452958261612 0.000145058448579496 -0.0832968976679487 0.368143524727499 miRNATAP -0.183804275894451 2.13838344910108e-05 NA NA NA hsa-miR-26b-5p MAP4K3 -0.254478038884324 0.0285227763044636 -0.0832968976679487 0.368143524727499 miRNAWalker2_validate -0.123042817675317 0.000389788928496791 NA NA NA hsa-miR-342-3p MAP4K3 0.99756868977753 9.28499866272332e-10 -0.0832968976679487 0.368143524727499 miRanda -0.163145187158955 7.86612463140358e-12 NA NA NA hsa-let-7c-5p MAP4K4 -2.07953368242668 3.46048888391218e-23 0.53744933005158 3.91532736300518e-07 MirTarget -0.176083147439417 1.22246714507239e-17 NA NA NA hsa-let-7d-5p MAP4K4 0.481757661442508 3.66030810124939e-07 0.53744933005158 3.91532736300518e-07 MirTarget -0.20029588805326 4.31463112358949e-05 NA NA NA hsa-let-7g-5p MAP4K4 -0.250780249469264 0.00939610188330072 0.53744933005158 3.91532736300518e-07 MirTarget -0.31138526055947 7.859216387915e-11 NA NA NA hsa-miR-10a-5p MAP4K4 -0.316491613573591 0.148093857656453 0.53744933005158 3.91532736300518e-07 MirTarget -0.104574773398422 7.32340181794919e-07 NA NA NA hsa-miR-141-3p MAP4K4 0.730011517758706 0.000120338355004032 0.53744933005158 3.91532736300518e-07 TargetScan -0.108510662846869 7.76466009036957e-06 24013097 To understand how miR-141 mediates the phenotype of pancreatic cancer cells a bioinformatics tool was used to identify MAP4K4 as a potential target of miR-141; The Dual-Luciferase reporter gene assay showed that miR-141 binds directly to the 3'-untranslated region 3'UTR of MAP4K4 to inhibit MAP4K4 expression; Western blot and quantitative real-time PCR qRT-PCR analyses revealed that MAP4K4 expression was inversely correlated with miR-141 expression both in pancreatic cancer samples and cell lines; In a nude mouse xenograft model both overexpression of miR-141 and knockdown of MAP4K4 significantly repressed pancreatic cancer cell growth; Therefore we conclude that miR-141 targets MAP4K4 acts as a tumor suppressor in pancreatic cancer cells and may serve as a novel therapeutic agent for miRNA-based pancreatic cancer therapy pancreatic cancer hsa-miR-142-5p MAP4K4 0.288897753038094 0.0900009317815725 0.53744933005158 3.91532736300518e-07 PITA -0.125141029589021 4.19793825855822e-06 NA NA NA hsa-miR-148a-5p MAP4K4 -1.00478606532747 1.38045244999229e-07 0.53744933005158 3.91532736300518e-07 MirTarget;miRNATAP -0.128052833523055 8.46512367570428e-08 NA NA NA hsa-miR-200b-3p MAP4K4 0.0717138787925347 0.682858087587209 0.53744933005158 3.91532736300518e-07 TargetScan -0.16957524554745 9.19212717990763e-11 NA NA NA hsa-miR-217 MAP4K4 -1.35391381055929 2.42394951427902e-09 0.53744933005158 3.91532736300518e-07 miRanda -0.10287338925566 2.7700298982244e-07 NA NA NA hsa-miR-23b-3p MAP4K4 -0.497563803223134 3.31483353357535e-05 0.53744933005158 3.91532736300518e-07 MirTarget;miRNATAP -0.240133278908801 3.37987077728007e-10 NA NA NA hsa-miR-29a-3p MAP4K4 -1.26881270980079 2.82496991513463e-22 0.53744933005158 3.91532736300518e-07 miRNATAP -0.187912134356248 2.98480630728492e-08 NA NA NA hsa-miR-29b-3p MAP4K4 -0.110721443686039 0.511264554091106 0.53744933005158 3.91532736300518e-07 miRNATAP -0.175099048368473 1.3498705821552e-10 NA NA NA hsa-miR-29c-3p MAP4K4 -2.08166260448948 8.3238369390898e-24 0.53744933005158 3.91532736300518e-07 miRNATAP -0.202511656902744 8.8154891300514e-23 NA NA NA hsa-miR-34a-5p MAP4K4 -0.117372471043915 0.364001947180738 0.53744933005158 3.91532736300518e-07 MirTarget -0.349626218977062 6.2445112422893e-24 NA NA NA hsa-miR-429 MAP4K4 0.559451508722375 0.00563641638673083 0.53744933005158 3.91532736300518e-07 PITA;miRanda;miRNATAP -0.1145054445932 5.14331272525401e-07 NA NA NA hsa-miR-582-3p MAP4K4 -0.248056267546012 0.143798829508405 0.53744933005158 3.91532736300518e-07 MirTarget -0.137241508710362 4.82133408087622e-07 NA NA NA hsa-miR-7-1-3p MAP4K4 1.13646121619622 1.49823237535933e-14 0.53744933005158 3.91532736300518e-07 mirMAP -0.106882934659483 0.000498729346115304 NA NA NA hsa-miR-130a-3p MAPK1 0.67051191119964 4.89747518735144e-06 -0.0253189255173565 0.755655647597946 mirMAP -0.119879003954416 4.21355197025158e-07 NA NA NA hsa-miR-140-5p MAPK1 -0.412389003031485 0.000136051708543369 -0.0253189255173565 0.755655647597946 miRanda -0.106820947603036 0.00107357303022432 NA NA NA hsa-miR-16-2-3p MAPK1 1.1567130855258 1.01867256952189e-14 -0.0253189255173565 0.755655647597946 mirMAP -0.118882902026294 1.87389146405289e-07 NA NA NA hsa-miR-19a-3p MAPK1 1.35800152353624 2.80940447111944e-12 -0.0253189255173565 0.755655647597946 mirMAP -0.108060075233242 6.73894767696324e-10 NA NA NA hsa-miR-19b-3p MAPK1 0.538732279378089 0.000622008277870679 -0.0253189255173565 0.755655647597946 mirMAP -0.153151975431285 2.83628955522989e-12 NA NA NA hsa-miR-24-1-5p MAPK1 -0.0503110566834755 0.742860080224713 -0.0253189255173565 0.755655647597946 mirMAP -0.116961525723256 3.20301669196585e-07 NA NA NA hsa-miR-29a-5p MAPK1 0.323252792625584 0.0370417231222825 -0.0253189255173565 0.755655647597946 mirMAP -0.100820598289556 8.60387631678624e-06 NA NA NA hsa-miR-29b-2-5p MAPK1 -0.502720326849742 0.000730448246894952 -0.0253189255173565 0.755655647597946 mirMAP -0.143966940664653 6.76991395724673e-10 NA NA NA hsa-miR-29b-3p MAPK1 -0.110721443686039 0.511264554091106 -0.0253189255173565 0.755655647597946 mirMAP -0.155562785937532 3.13794270245465e-14 NA NA NA hsa-miR-30b-5p MAPK1 -0.400238605368173 0.00346540992719245 -0.0253189255173565 0.755655647597946 mirMAP -0.174014396815711 6.15963591886978e-12 NA NA NA hsa-miR-30c-5p MAPK1 0.021222006155897 0.886366656528128 -0.0253189255173565 0.755655647597946 mirMAP -0.16816380351527 6.00043626518046e-13 NA NA NA hsa-miR-30d-3p MAPK1 -0.577371911152798 2.02950840095287e-06 -0.0253189255173565 0.755655647597946 mirMAP -0.122142266216853 2.26778585246636e-05 NA NA NA hsa-miR-32-5p MAPK1 -0.317310201890053 0.0102525324475293 -0.0253189255173565 0.755655647597946 mirMAP -0.118206616474112 3.38014161673994e-05 NA NA NA hsa-miR-320a MAPK1 0.801356001806321 4.91397101474502e-09 -0.0253189255173565 0.755655647597946 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.125451646590753 6.80368047080733e-07 NA NA NA hsa-miR-338-3p MAPK1 -0.948755228846395 8.99167125682392e-08 -0.0253189255173565 0.755655647597946 miRanda -0.129835880343114 1.75257870680844e-11 NA NA NA hsa-miR-342-3p MAPK1 0.99756868977753 9.28499866272332e-10 -0.0253189255173565 0.755655647597946 miRanda;mirMAP -0.169189955454587 3.43413416819006e-16 NA NA NA hsa-miR-34a-5p MAPK1 -0.117372471043915 0.364001947180738 -0.0253189255173565 0.755655647597946 mirMAP -0.233668876576953 1.32503113597025e-18 NA NA NA hsa-miR-362-3p MAPK1 -0.697212068252854 2.61718493418184e-06 -0.0253189255173565 0.755655647597946 mirMAP -0.110141441408008 2.93292282524057e-06 NA NA NA hsa-miR-362-5p MAPK1 0.41089772861323 0.0404254902071382 -0.0253189255173565 0.755655647597946 mirMAP -0.144103835470426 3.00694449777536e-17 NA NA NA hsa-miR-374a-3p MAPK1 -0.299190081500425 0.00682975596757891 -0.0253189255173565 0.755655647597946 mirMAP -0.110281311853038 0.000567634401408648 NA NA NA hsa-miR-374b-5p MAPK1 -0.288413933608091 0.0041474558664058 -0.0253189255173565 0.755655647597946 mirMAP -0.193539977082972 2.99670270207311e-08 NA NA NA hsa-miR-454-3p MAPK1 1.54137391927201 4.15861570449376e-20 -0.0253189255173565 0.755655647597946 mirMAP -0.134566799939584 1.33034028771569e-11 NA NA NA hsa-miR-500a-3p MAPK1 0.457959128173392 0.000691656736597067 -0.0253189255173565 0.755655647597946 mirMAP -0.181280312300052 1.44783347897454e-12 NA NA NA hsa-miR-501-3p MAPK1 0.820141346319976 1.74562930463389e-08 -0.0253189255173565 0.755655647597946 mirMAP -0.113690992046206 1.83281067549205e-06 NA NA NA hsa-miR-501-5p MAPK1 1.02806906860218 1.63456814370548e-09 -0.0253189255173565 0.755655647597946 mirMAP -0.102516454465174 5.70704874257852e-07 NA NA NA hsa-miR-502-3p MAPK1 -0.165138869760313 0.106881047403914 -0.0253189255173565 0.755655647597946 mirMAP -0.118442041096273 0.000641376645364786 NA NA NA hsa-miR-505-3p MAPK1 0.912823669571645 4.0549774967148e-13 -0.0253189255173565 0.755655647597946 mirMAP -0.112388892923579 4.07425901957411e-05 NA NA NA hsa-miR-660-5p MAPK1 -0.202705992887645 0.101093376073573 -0.0253189255173565 0.755655647597946 mirMAP -0.195287313401534 3.91978206929352e-12 NA NA NA hsa-miR-130a-3p MAPK10 0.67051191119964 4.89747518735144e-06 -0.515911722339727 0.0831884442739904 miRNATAP -0.257567155860406 0.00339348902810216 NA NA NA hsa-miR-146b-5p MAPK10 0.917975986853978 3.33749259316025e-09 -0.515911722339727 0.0831884442739904 miRanda -0.295681226115733 0.000329641658393179 NA NA NA hsa-miR-193a-3p MAPK10 0.22120710726779 0.111827069464729 -0.515911722339727 0.0831884442739904 miRanda;miRNATAP -0.493948546424074 1.00271078231064e-07 NA NA NA hsa-miR-222-3p MAPK10 1.08197052578759 2.32604040301699e-14 -0.515911722339727 0.0831884442739904 miRNATAP -0.276859620137527 0.00195454932101181 NA NA NA hsa-miR-450b-5p MAPK10 1.25529820885833 1.18847120528666e-15 -0.515911722339727 0.0831884442739904 mirMAP -0.280454869207043 0.000487914265247545 NA NA NA hsa-miR-455-5p MAPK10 1.408595672323 5.52039116456697e-22 -0.515911722339727 0.0831884442739904 miRanda -0.266609539974593 0.00177277067425019 NA NA NA hsa-let-7a-5p MAPK11 -0.439381775414001 3.1119785480023e-05 0.655585654068144 2.41371018464999e-06 miRNAWalker2_validate -0.230442250436062 6.64800124704327e-05 NA NA NA hsa-miR-140-3p MAPK11 -0.967453553824782 7.6999446305445e-23 0.655585654068144 2.41371018464999e-06 mirMAP -0.184846142335231 0.00205097804543975 NA NA NA hsa-miR-125a-3p MAPK13 0.116035800853173 0.444825559956959 -0.508562119880784 0.000695199481126942 miRanda -0.196155695894181 5.23442841481487e-06 NA NA NA hsa-miR-320a MAPK14 0.801356001806321 4.91397101474502e-09 -0.0956556568512745 0.173051538497392 PITA;miRanda -0.10567397029139 1.23981896330697e-06 NA NA NA hsa-miR-320b MAPK3 1.23473838180754 3.04337566045537e-14 -0.858383500175909 4.87731698141196e-21 miRNAWalker2_validate -0.150409382751881 7.4168687441981e-10 NA NA NA hsa-miR-34a-5p MAPK3 -0.117372471043915 0.364001947180738 -0.858383500175909 4.87731698141196e-21 miRNAWalker2_validate -0.142473103912921 8.01686085043296e-06 NA NA NA hsa-miR-423-3p MAPK3 1.20230884409188 2.57129723627633e-23 -0.858383500175909 4.87731698141196e-21 miRNAWalker2_validate -0.111095021124406 0.000694439178470412 NA NA NA hsa-miR-423-5p MAPK3 0.60141781325829 1.62940950644999e-07 -0.858383500175909 4.87731698141196e-21 miRNATAP -0.162814696094577 4.59419685322422e-06 NA NA NA hsa-miR-542-3p MAPK3 0.643308814904977 8.81635403230104e-07 -0.858383500175909 4.87731698141196e-21 miRanda -0.109224164762627 0.000481993746155519 NA NA NA hsa-miR-330-5p MAPK7 0.944693925383906 5.04972895657346e-13 -0.186782324507704 0.0326407147051318 miRanda -0.118622799815835 2.91926449885763e-05 NA NA NA hsa-miR-125a-5p MAPK8 0.215366061934933 0.119550904549401 -0.172407388594656 0.268657395750659 miRNAWalker2_validate -0.143608044868371 0.00350932932688087 NA NA NA hsa-miR-193b-3p MAPK8 1.72788400801602 3.0722151264559e-21 -0.172407388594656 0.268657395750659 miRNAWalker2_validate -0.103541446629706 0.00369576960582702 NA NA NA hsa-miR-301a-3p MAPK8 2.14132004241926 4.46255413526808e-25 -0.172407388594656 0.268657395750659 mirMAP -0.112933118413377 0.000284581455563168 NA NA NA hsa-miR-30b-5p MAPK8 -0.400238605368173 0.00346540992719245 -0.172407388594656 0.268657395750659 mirMAP -0.138590879277345 0.00519075072579384 NA NA NA hsa-miR-30c-5p MAPK8 0.021222006155897 0.886366656528128 -0.172407388594656 0.268657395750659 mirMAP -0.20973489202979 4.16686473002559e-06 NA NA NA hsa-miR-454-3p MAPK8 1.54137391927201 4.15861570449376e-20 -0.172407388594656 0.268657395750659 mirMAP -0.192614648253284 6.15604470021583e-07 NA NA NA hsa-miR-22-5p MAPK8IP2 0.706731861922839 3.44318705980007e-07 0.156706368182207 0.544263436426249 mirMAP -0.285216350829447 0.000385925821649798 NA NA NA hsa-miR-31-5p MAPK8IP2 2.79079137807505 1.72181058015659e-13 0.156706368182207 0.544263436426249 mirMAP -0.152978520291781 1.34537443191126e-07 NA NA NA hsa-miR-323a-3p MAPK8IP2 0.554923914792824 0.00856909375866133 0.156706368182207 0.544263436426249 mirMAP -0.150564366469309 0.00546326937367778 NA NA NA hsa-miR-338-3p MAPK8IP2 -0.948755228846395 8.99167125682392e-08 0.156706368182207 0.544263436426249 mirMAP -0.166986113316923 0.00774055287989645 NA NA NA hsa-miR-3614-5p MAPK8IP2 0.955957969488529 2.95347675446694e-05 0.156706368182207 0.544263436426249 mirMAP -0.184270778582769 0.000153605336160252 NA NA NA hsa-miR-424-5p MAPK8IP2 1.48125289532143 9.10372985713165e-19 0.156706368182207 0.544263436426249 mirMAP -0.281654939489652 1.29315623996919e-05 NA NA NA hsa-miR-1262 MAPK8IP3 -0.573333840008993 0.000460467165110432 0.522159919139376 9.29082555717564e-06 mirMAP -0.14887882718016 3.79161032020488e-06 NA NA NA hsa-miR-221-5p MAPK8IP3 -0.53190793287441 0.0379158336541952 0.522159919139376 9.29082555717564e-06 miRNATAP -0.139497316205451 1.52453581361984e-12 NA NA NA hsa-miR-326 MAPK8IP3 -0.425943992128769 0.0415010315530797 0.522159919139376 9.29082555717564e-06 mirMAP -0.105492905668677 1.92367980817007e-05 NA NA NA hsa-miR-361-5p MAPK9 0.0803683277369505 0.314043140368058 -0.132566719441631 0.0608210268784422 miRanda -0.133370328666221 0.000635857332285973 NA NA NA hsa-miR-421 MAPKAPK3 0.945488088619653 2.35762398527362e-09 -1.16747097975825 3.34312421353914e-29 miRanda -0.105833325987805 0.000400151748502369 NA NA NA hsa-miR-429 MAPKAPK3 0.559451508722375 0.00563641638673083 -1.16747097975825 3.34312421353914e-29 miRNATAP -0.142555684847675 1.01426629753754e-09 NA NA NA hsa-miR-146b-5p MAPT 0.917975986853978 3.33749259316025e-09 -3.48378461491486 7.33514391170208e-29 PITA;miRNATAP -0.329427459415071 0.000315896569106926 NA NA NA hsa-miR-148b-5p MAPT 1.1533193737265 7.26420964688337e-13 -3.48378461491486 7.33514391170208e-29 mirMAP -0.461121622177613 1.65428700778086e-07 NA NA NA hsa-miR-181a-5p MAPT 0.819060835827404 1.38616688310277e-13 -3.48378461491486 7.33514391170208e-29 miRNATAP -0.584762785325646 4.25491209295055e-06 NA NA NA hsa-miR-181b-5p MAPT 0.974255518824355 2.64876280203475e-16 -3.48378461491486 7.33514391170208e-29 miRNATAP -0.529996333531695 6.5009572960919e-06 NA NA NA hsa-miR-18a-3p MAPT 1.82583720936229 7.51297960972179e-19 -3.48378461491486 7.33514391170208e-29 MirTarget;miRNATAP -0.392745610452973 1.03438805257365e-08 NA NA NA hsa-miR-2355-3p MAPT 1.58434563546762 4.06578912176206e-18 -3.48378461491486 7.33514391170208e-29 miRNATAP -0.398431096084892 1.38723452143635e-07 NA NA NA hsa-miR-27b-5p MAPT 0.580870079022649 0.000181529223377382 -3.48378461491486 7.33514391170208e-29 mirMAP -0.418887956254459 5.3653782002377e-06 NA NA NA hsa-miR-31-5p MAPT 2.79079137807505 1.72181058015659e-13 -3.48378461491486 7.33514391170208e-29 mirMAP -0.260212844585478 1.53223548681886e-12 NA NA NA hsa-miR-320a MAPT 0.801356001806321 4.91397101474502e-09 -3.48378461491486 7.33514391170208e-29 miRanda -0.34692732607253 0.00084225825729023 NA NA NA hsa-miR-320b MAPT 1.23473838180754 3.04337566045537e-14 -3.48378461491486 7.33514391170208e-29 miRanda -0.389337862208822 6.06849648039373e-06 NA NA NA hsa-miR-342-3p MAPT 0.99756868977753 9.28499866272332e-10 -3.48378461491486 7.33514391170208e-29 MirTarget;miRanda -0.346920373338547 6.47331986805674e-05 NA NA NA hsa-miR-429 MAPT 0.559451508722375 0.00563641638673083 -3.48378461491486 7.33514391170208e-29 miRNATAP -0.323515098707596 4.79947163924242e-06 NA NA NA hsa-miR-450b-5p MAPT 1.25529820885833 1.18847120528666e-15 -3.48378461491486 7.33514391170208e-29 mirMAP -0.308513400442395 0.000553711105572275 NA NA NA hsa-miR-484 MAPT 0.918280909791707 1.39168306854263e-14 -3.48378461491486 7.33514391170208e-29 mirMAP -0.684070187596101 4.81522333233824e-09 NA NA NA hsa-miR-505-5p MAPT 1.25888458076414 7.80089782306577e-13 -3.48378461491486 7.33514391170208e-29 MirTarget -0.338723068146787 2.2372315120364e-05 NA NA NA hsa-miR-589-3p MAPT 1.59559692667315 6.2886410639161e-15 -3.48378461491486 7.33514391170208e-29 mirMAP -0.454536227594362 1.01247104371279e-10 NA NA NA hsa-miR-589-5p MAPT 0.807877250867909 4.12262850391353e-14 -3.48378461491486 7.33514391170208e-29 mirMAP -0.731863738496164 2.32591918766011e-08 NA NA NA hsa-miR-7-1-3p MAPT 1.13646121619622 1.49823237535933e-14 -3.48378461491486 7.33514391170208e-29 mirMAP -0.60937084378147 7.77587336467547e-11 NA NA NA hsa-miR-766-3p MAPT 1.07002176594541 8.2375790648059e-16 -3.48378461491486 7.33514391170208e-29 MirTarget -0.534411116313404 3.46219513016675e-07 NA NA NA hsa-miR-93-3p MAPT 1.69225547123293 1.50964095575087e-25 -3.48378461491486 7.33514391170208e-29 mirMAP -0.505678511901037 1.5100450080543e-09 NA NA NA hsa-miR-940 MAPT 1.25303020594374 1.3005368359451e-10 -3.48378461491486 7.33514391170208e-29 mirMAP -0.271004384006676 0.000220224604768884 NA NA NA hsa-miR-944 MAPT 1.47323925060177 2.61626403984929e-13 -3.48378461491486 7.33514391170208e-29 mirMAP -0.445754192125442 8.96645387038969e-11 NA NA NA hsa-miR-96-5p MAPT 1.42326703011157 4.39736150032373e-14 -3.48378461491486 7.33514391170208e-29 mirMAP -0.428609068784896 5.92257216109451e-09 NA NA NA hsa-miR-22-3p MAX 0.00776313533473072 0.926356548861307 -0.0558412172758436 0.386366137724497 miRNATAP -0.141935669596862 2.39153375154353e-05 NA NA NA hsa-miR-28-5p MAX -0.026996999089909 0.733047113251652 -0.0558412172758436 0.386366137724497 miRanda -0.173285826277801 1.15604060121319e-06 NA NA NA hsa-let-7a-3p MEF2C 0.0966652362351867 0.423761916840503 -1.09705312762588 2.76488508702956e-05 MirTarget;miRNATAP -0.408808167604343 1.75749710781141e-05 NA NA NA hsa-let-7f-1-3p MEF2C 0.700374242293247 8.65000484720084e-08 -1.09705312762588 2.76488508702956e-05 MirTarget -0.232727821346608 0.00755740660960819 NA NA NA hsa-miR-103a-2-5p MEF2C 1.37988337975616 6.74852943995612e-08 -1.09705312762588 2.76488508702956e-05 MirTarget -0.325543136097253 6.83152367430806e-12 NA NA NA hsa-miR-130b-5p MEF2C 1.77265255049999 1.43627774829684e-29 -1.09705312762588 2.76488508702956e-05 MirTarget;miRNATAP -0.388675034397053 1.30133815135376e-08 NA NA NA hsa-miR-135b-5p MEF2C 1.5570143078477 4.60753610971455e-13 -1.09705312762588 2.76488508702956e-05 MirTarget -0.443589590674785 1.45019482686629e-18 NA NA NA hsa-miR-182-5p MEF2C 1.15060905311096 6.25565852529946e-10 -1.09705312762588 2.76488508702956e-05 MirTarget;miRNATAP -0.505901504409844 8.44836388979801e-18 NA NA NA hsa-miR-183-5p MEF2C 1.4313129319945 6.25230916431996e-14 -1.09705312762588 2.76488508702956e-05 MirTarget;miRNATAP -0.516964084220012 7.41137804982983e-20 NA NA NA hsa-miR-18a-3p MEF2C 1.82583720936229 7.51297960972179e-19 -1.09705312762588 2.76488508702956e-05 MirTarget;miRNATAP -0.409022763184111 3.6826148120208e-14 NA NA NA hsa-miR-18a-5p MEF2C 1.65455873230328 3.76457892277775e-20 -1.09705312762588 2.76488508702956e-05 MirTarget -0.528824165113952 5.7030218670876e-19 NA NA NA hsa-miR-19a-3p MEF2C 1.35800152353624 2.80940447111944e-12 -1.09705312762588 2.76488508702956e-05 miRNATAP -0.496937734920839 6.37732758464453e-19 NA NA NA hsa-miR-19b-3p MEF2C 0.538732279378089 0.000622008277870679 -1.09705312762588 2.76488508702956e-05 miRNATAP -0.56897345372395 9.87765764848047e-16 NA NA NA hsa-miR-200c-5p MEF2C 0.904697667677842 1.36157973413856e-06 -1.09705312762588 2.76488508702956e-05 MirTarget -0.526971380904934 2.82847691012271e-19 NA NA NA hsa-miR-203a-3p MEF2C 0.0441399794719697 0.880456392176704 -1.09705312762588 2.76488508702956e-05 MirTarget -0.266452849277885 3.85317874944774e-12 NA NA NA hsa-miR-205-3p MEF2C 1.2960640797621 5.80786479909147e-11 -1.09705312762588 2.76488508702956e-05 mirMAP -0.53418496036683 1.43879500299641e-22 NA NA NA hsa-miR-21-5p MEF2C 1.62465922021121 3.44191300985109e-58 -1.09705312762588 2.76488508702956e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.313515069107813 0.00208088735786051 NA NA NA hsa-miR-224-3p MEF2C 0.502645536188015 0.0081142387260641 -1.09705312762588 2.76488508702956e-05 MirTarget;mirMAP -0.405161399464308 1.19421435147366e-11 NA NA NA hsa-miR-2355-5p MEF2C 1.47205546931107 8.65192179636668e-19 -1.09705312762588 2.76488508702956e-05 MirTarget -0.337187478038153 3.47854843599331e-07 NA NA NA hsa-miR-27a-3p MEF2C 0.348456440505425 0.00126682892514312 -1.09705312762588 2.76488508702956e-05 miRNATAP -0.35506556987963 0.000860397370028119 NA NA NA hsa-miR-320a MEF2C 0.801356001806321 4.91397101474502e-09 -1.09705312762588 2.76488508702956e-05 miRanda -0.326003344643129 7.93357589873806e-05 NA NA NA hsa-miR-320b MEF2C 1.23473838180754 3.04337566045537e-14 -1.09705312762588 2.76488508702956e-05 miRanda -0.395958604914668 6.16685256730046e-09 NA NA NA hsa-miR-324-3p MEF2C 0.867391246413545 3.63808540490361e-10 -1.09705312762588 2.76488508702956e-05 miRNATAP -0.466612406586499 7.99956933328126e-09 NA NA NA hsa-miR-331-5p MEF2C 0.851618030062133 1.42670149420057e-14 -1.09705312762588 2.76488508702956e-05 PITA -0.54362496384821 6.78971505983572e-08 NA NA NA hsa-miR-335-3p MEF2C 0.336785882180547 0.0542446207938138 -1.09705312762588 2.76488508702956e-05 MirTarget;mirMAP -0.226032648453241 0.000565876823229673 NA NA NA hsa-miR-33a-3p MEF2C 0.20371038027126 0.212335697664505 -1.09705312762588 2.76488508702956e-05 MirTarget;mirMAP;miRNATAP -0.400005130990669 1.54203233158564e-08 NA NA NA hsa-miR-33b-5p MEF2C 0.681845193600723 0.00407790722487864 -1.09705312762588 2.76488508702956e-05 mirMAP -0.323593327486518 3.56338628408445e-11 NA NA NA hsa-miR-3613-5p MEF2C 0.410363235348614 0.00534956684590092 -1.09705312762588 2.76488508702956e-05 MirTarget;miRNATAP -0.258058904741457 0.000920701367790727 NA NA NA hsa-miR-425-5p MEF2C 0.931027421598738 6.46235724408844e-08 -1.09705312762588 2.76488508702956e-05 MirTarget;miRNATAP -0.377645994049741 6.70397781716215e-09 NA NA NA hsa-miR-429 MEF2C 0.559451508722375 0.00563641638673083 -1.09705312762588 2.76488508702956e-05 miRanda;miRNATAP -0.573428807097437 2.29395277157552e-26 NA NA NA hsa-miR-452-5p MEF2C 0.373288744398455 0.0348485937209964 -1.09705312762588 2.76488508702956e-05 MirTarget;miRNATAP -0.307066999561315 1.91788343902226e-06 NA NA NA hsa-miR-550a-3p MEF2C 1.63595944765448 5.87048146042097e-24 -1.09705312762588 2.76488508702956e-05 MirTarget -0.45744836274961 1.35957319055853e-11 NA NA NA hsa-miR-590-3p MEF2C 0.221436901462551 0.0965904764063157 -1.09705312762588 2.76488508702956e-05 mirMAP -0.260137280807687 0.00263517543731336 NA NA NA hsa-miR-590-5p MEF2C 0.763025362395968 3.65305892505623e-09 -1.09705312762588 2.76488508702956e-05 MirTarget;PITA;miRanda;miRNATAP -0.561798756068857 8.03509521541941e-11 NA NA NA hsa-miR-7-1-3p MEF2C 1.13646121619622 1.49823237535933e-14 -1.09705312762588 2.76488508702956e-05 MirTarget;mirMAP -0.498720595553446 2.22312511729722e-11 NA NA NA hsa-miR-744-3p MEF2C 1.18973028739247 4.23716909078104e-10 -1.09705312762588 2.76488508702956e-05 MirTarget;miRNATAP -0.372752233412902 1.70264347829807e-10 NA NA NA hsa-miR-9-5p MEF2C 1.65694862043766 2.08325802567323e-05 -1.09705312762588 2.76488508702956e-05 MirTarget;miRNATAP -0.160628049685574 2.7380165875409e-08 NA NA NA hsa-miR-92a-3p MEF2C 0.994679542307232 1.32587679156217e-16 -1.09705312762588 2.76488508702956e-05 miRNAWalker2_validate -0.838324311787792 8.93060544333734e-21 NA NA NA hsa-miR-940 MEF2C 1.25303020594374 1.3005368359451e-10 -1.09705312762588 2.76488508702956e-05 PITA;miRNATAP -0.295686631692294 3.58345073187404e-07 NA NA NA hsa-miR-944 MEF2C 1.47323925060177 2.61626403984929e-13 -1.09705312762588 2.76488508702956e-05 mirMAP -0.34396146985512 3.56317762229115e-10 NA NA NA hsa-miR-96-5p MEF2C 1.42326703011157 4.39736150032373e-14 -1.09705312762588 2.76488508702956e-05 miRNATAP -0.595436673029772 7.04511627844217e-26 NA NA NA hsa-miR-125a-5p MKNK2 0.215366061934933 0.119550904549401 -0.962738078363193 5.11370312057539e-15 MirTarget -0.182296154591485 4.37121856503566e-06 NA NA NA hsa-miR-21-5p MKNK2 1.62465922021121 3.44191300985109e-58 -0.962738078363193 5.11370312057539e-15 miRNAWalker2_validate -0.355184299262684 1.03287130408219e-13 NA NA NA hsa-miR-214-5p MKNK2 0.236510288548811 0.206226406026677 -0.962738078363193 5.11370312057539e-15 MirTarget -0.183619739930208 2.44856561157837e-10 NA NA NA hsa-miR-370-3p MKNK2 -0.362239506850908 0.0857012995712968 -0.962738078363193 5.11370312057539e-15 MirTarget -0.155273278113052 1.94651281555559e-09 NA NA NA hsa-miR-874-3p MKNK2 0.329113506343389 0.0176906966227927 -0.962738078363193 5.11370312057539e-15 MirTarget -0.136710733773288 0.000572099128820266 NA NA NA hsa-miR-103a-2-5p MRAS 1.37988337975616 6.74852943995612e-08 -0.342440778673446 0.082389718623168 mirMAP -0.206194225189353 7.78463885862847e-09 NA NA NA hsa-miR-130b-5p MRAS 1.77265255049999 1.43627774829684e-29 -0.342440778673446 0.082389718623168 mirMAP -0.184544915637701 0.000348401432904118 NA NA NA hsa-miR-135b-5p MRAS 1.5570143078477 4.60753610971455e-13 -0.342440778673446 0.082389718623168 miRNATAP -0.302311163873935 1.70822000424153e-15 NA NA NA hsa-miR-15a-5p MRAS 0.783550182002274 2.60699595655907e-11 -0.342440778673446 0.082389718623168 miRNATAP -0.311494137885706 1.4045700221351e-05 NA NA NA hsa-miR-15b-5p MRAS 0.85315666454713 3.79816274836297e-12 -0.342440778673446 0.082389718623168 miRNATAP -0.342744602619392 5.06934381233791e-07 NA NA NA hsa-miR-16-5p MRAS 0.521122945828175 1.40561786410572e-06 -0.342440778673446 0.082389718623168 miRNATAP -0.303378974653949 0.000125675331417403 NA NA NA hsa-miR-182-5p MRAS 1.15060905311096 6.25565852529946e-10 -0.342440778673446 0.082389718623168 miRNATAP -0.341668618028769 1.28080501162951e-14 NA NA NA hsa-miR-205-3p MRAS 1.2960640797621 5.80786479909147e-11 -0.342440778673446 0.082389718623168 mirMAP -0.42925916495279 3.54960170872593e-26 NA NA NA hsa-miR-29b-3p MRAS -0.110721443686039 0.511264554091106 -0.342440778673446 0.082389718623168 mirMAP -0.167183757191434 0.00105039753128202 NA NA NA hsa-miR-3065-3p MRAS -0.543069092777161 0.0213164885178151 -0.342440778673446 0.082389718623168 miRNATAP -0.240178367762243 1.73585393933944e-11 NA NA NA hsa-miR-30d-3p MRAS -0.577371911152798 2.02950840095287e-06 -0.342440778673446 0.082389718623168 mirMAP -0.194727935910175 0.0057842454154096 NA NA NA hsa-miR-324-5p MRAS 1.66709479707179 1.45961450445769e-23 -0.342440778673446 0.082389718623168 miRanda -0.278748709550101 1.07024611680967e-08 NA NA NA hsa-miR-33a-3p MRAS 0.20371038027126 0.212335697664505 -0.342440778673446 0.082389718623168 mirMAP -0.368690726645383 2.07500569098879e-12 NA NA NA hsa-miR-429 MRAS 0.559451508722375 0.00563641638673083 -0.342440778673446 0.082389718623168 miRanda;miRNATAP -0.422943115878969 1.30081340821955e-25 NA NA NA hsa-miR-582-5p MRAS -0.0366995972742474 0.821827119138923 -0.342440778673446 0.082389718623168 mirMAP -0.212815716784369 5.3127911126408e-05 NA NA NA hsa-miR-652-3p MRAS 0.358960167804889 0.00317496895411853 -0.342440778673446 0.082389718623168 miRNAWalker2_validate -0.248906342611732 0.000426081250483132 NA NA NA hsa-miR-7-1-3p MRAS 1.13646121619622 1.49823237535933e-14 -0.342440778673446 0.082389718623168 mirMAP -0.35614618909667 1.81614295376787e-10 NA NA NA hsa-miR-96-5p MRAS 1.42326703011157 4.39736150032373e-14 -0.342440778673446 0.082389718623168 TargetScan;miRNATAP -0.417398158655325 1.21247244800582e-22 NA NA NA hsa-let-7c-5p MYC -2.07953368242668 3.46048888391218e-23 -0.32772106147221 0.0189770115533449 miRNAWalker2_validate;miRTarBase -0.107421906050131 0.000103545158346461 22128178 MicroRNA let 7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells prostate cancer hsa-miR-34a-5p MYC -0.117372471043915 0.364001947180738 -0.32772106147221 0.0189770115533449 miRNAWalker2_validate;miRTarBase -0.157674637324898 0.000854501792660625 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-let-7a-3p NF1 0.0966652362351867 0.423761916840503 0.202582143995177 0.0682023281367416 mirMAP -0.204565221520281 2.97421855571757e-07 NA NA NA hsa-miR-10b-5p NF1 -0.582989331935508 4.56688330655626e-06 0.202582143995177 0.0682023281367416 miRNAWalker2_validate;miRTarBase -0.232692421572101 4.41373987196264e-10 27494896 Knockdown and overexpression experiments revealed that the increase is mediated by NF1 and RhoC downstream targets of miR-10b that affect cytoskeletal dynamics through the ROCK pathway breast cancer hsa-miR-139-5p NF1 -1.46099200329485 7.85040381494472e-22 0.202582143995177 0.0682023281367416 miRanda -0.142689547780717 2.52419043095661e-06 NA NA NA hsa-miR-146b-5p NF1 0.917975986853978 3.33749259316025e-09 0.202582143995177 0.0682023281367416 miRanda -0.101517532392921 0.000939322573930778 NA NA NA hsa-miR-15a-5p NF1 0.783550182002274 2.60699595655907e-11 0.202582143995177 0.0682023281367416 MirTarget -0.290046613725367 2.74486752534918e-13 NA NA NA hsa-miR-16-1-3p NF1 0.955017760172879 5.95379292601146e-11 0.202582143995177 0.0682023281367416 MirTarget -0.141154204022266 1.39334296467952e-05 NA NA NA hsa-miR-193a-3p NF1 0.22120710726779 0.111827069464729 0.202582143995177 0.0682023281367416 miRanda -0.15302725188388 1.01911450285065e-05 NA NA NA hsa-miR-193b-3p NF1 1.72788400801602 3.0722151264559e-21 0.202582143995177 0.0682023281367416 miRNAWalker2_validate -0.115973751077598 4.41946471212787e-06 NA NA NA hsa-miR-199b-5p NF1 -1.08432682485992 7.68241801134089e-10 0.202582143995177 0.0682023281367416 miRanda -0.103150484548762 0.000126194259802808 NA NA NA hsa-miR-29a-5p NF1 0.323252792625584 0.0370417231222825 0.202582143995177 0.0682023281367416 MirTarget;miRNATAP -0.157117668501537 3.87889683736192e-07 NA NA NA hsa-miR-29b-1-5p NF1 1.39669186711325 4.36960953138935e-11 0.202582143995177 0.0682023281367416 mirMAP -0.125841233642717 1.34379204863701e-08 NA NA NA hsa-miR-30b-5p NF1 -0.400238605368173 0.00346540992719245 0.202582143995177 0.0682023281367416 MirTarget;mirMAP -0.201380053649291 7.98881698323558e-09 NA NA NA hsa-miR-30c-5p NF1 0.021222006155897 0.886366656528128 0.202582143995177 0.0682023281367416 MirTarget;mirMAP;miRNATAP -0.240438929594426 5.05599753712798e-14 NA NA NA hsa-miR-362-3p NF1 -0.697212068252854 2.61718493418184e-06 0.202582143995177 0.0682023281367416 miRanda -0.135093570028271 2.96334654425142e-05 NA NA NA hsa-miR-362-5p NF1 0.41089772861323 0.0404254902071382 0.202582143995177 0.0682023281367416 mirMAP -0.196998337465394 3.60486447739705e-17 NA NA NA hsa-miR-455-5p NF1 1.408595672323 5.52039116456697e-22 0.202582143995177 0.0682023281367416 miRanda -0.171845852250109 4.67158262719813e-08 NA NA NA hsa-miR-590-5p NF1 0.763025362395968 3.65305892505623e-09 0.202582143995177 0.0682023281367416 miRanda -0.127494302955795 0.000549385188521127 NA NA NA hsa-miR-130b-5p NFATC2 1.77265255049999 1.43627774829684e-29 -1.25486248564221 0.000172992176354394 MirTarget -0.514289720906144 3.45340671629822e-09 NA NA NA hsa-miR-16-2-3p NFATC2 1.1567130855258 1.01867256952189e-14 -1.25486248564221 0.000172992176354394 mirMAP -0.657909202427149 2.22088975341719e-12 NA NA NA hsa-miR-182-5p NFATC2 1.15060905311096 6.25565852529946e-10 -1.25486248564221 0.000172992176354394 mirMAP -0.547097191091464 5.39311037502917e-13 NA NA NA hsa-miR-186-5p NFATC2 0.353452958261612 0.000145058448579496 -1.25486248564221 0.000172992176354394 mirMAP -0.737589937834061 2.75639363716297e-06 NA NA NA hsa-miR-19a-3p NFATC2 1.35800152353624 2.80940447111944e-12 -1.25486248564221 0.000172992176354394 mirMAP -0.924100758885834 3.58487812401573e-42 NA NA NA hsa-miR-19b-3p NFATC2 0.538732279378089 0.000622008277870679 -1.25486248564221 0.000172992176354394 mirMAP -1.15509771675492 1.64102640977043e-41 NA NA NA hsa-miR-205-3p NFATC2 1.2960640797621 5.80786479909147e-11 -1.25486248564221 0.000172992176354394 mirMAP -0.343866501621686 1.8468695557269e-06 NA NA NA hsa-miR-222-3p NFATC2 1.08197052578759 2.32604040301699e-14 -1.25486248564221 0.000172992176354394 MirTarget -0.483064014402545 1.42535021555115e-06 NA NA NA hsa-miR-2355-3p NFATC2 1.58434563546762 4.06578912176206e-18 -1.25486248564221 0.000172992176354394 mirMAP -0.42812739127172 2.38490246638194e-08 NA NA NA hsa-miR-2355-5p NFATC2 1.47205546931107 8.65192179636668e-19 -1.25486248564221 0.000172992176354394 MirTarget -0.58837741374673 1.74879666791307e-12 NA NA NA hsa-miR-26b-3p NFATC2 0.421575313079363 0.00223298166810883 -1.25486248564221 0.000172992176354394 MirTarget -0.319217894210201 0.00264752852289272 NA NA NA hsa-miR-27b-5p NFATC2 0.580870079022649 0.000181529223377382 -1.25486248564221 0.000172992176354394 mirMAP -0.336293189286217 0.000339446551242512 NA NA NA hsa-miR-29a-5p NFATC2 0.323252792625584 0.0370417231222825 -1.25486248564221 0.000172992176354394 mirMAP;miRNATAP -0.544946324623055 5.46968828870313e-09 NA NA NA hsa-miR-30b-5p NFATC2 -0.400238605368173 0.00346540992719245 -1.25486248564221 0.000172992176354394 MirTarget;mirMAP -0.763262749165252 3.23713764040455e-13 NA NA NA hsa-miR-30c-5p NFATC2 0.021222006155897 0.886366656528128 -1.25486248564221 0.000172992176354394 MirTarget;mirMAP -0.819077629610369 1.45073885011096e-17 NA NA NA hsa-miR-31-3p NFATC2 2.10124531535908 1.70135756565194e-08 -1.25486248564221 0.000172992176354394 MirTarget -0.146949889334041 0.000140785099541377 NA NA NA hsa-miR-320a NFATC2 0.801356001806321 4.91397101474502e-09 -1.25486248564221 0.000172992176354394 MirTarget -0.59759720970056 1.06046391812254e-08 NA NA NA hsa-miR-320b NFATC2 1.23473838180754 3.04337566045537e-14 -1.25486248564221 0.000172992176354394 MirTarget -0.301551217089888 0.000590783452269324 NA NA NA hsa-miR-335-3p NFATC2 0.336785882180547 0.0542446207938138 -1.25486248564221 0.000172992176354394 mirMAP -0.294498129578907 0.000424975091200581 NA NA NA hsa-miR-33a-3p NFATC2 0.20371038027126 0.212335697664505 -1.25486248564221 0.000172992176354394 mirMAP -0.245013497318194 0.00723337082303761 NA NA NA hsa-miR-3607-3p NFATC2 1.01377165357363 9.13355519701165e-05 -1.25486248564221 0.000172992176354394 MirTarget;mirMAP -0.349460391273266 2.66876725963668e-10 NA NA NA hsa-miR-3613-5p NFATC2 0.410363235348614 0.00534956684590092 -1.25486248564221 0.000172992176354394 mirMAP -0.608571808652233 5.28086151872216e-10 NA NA NA hsa-miR-484 NFATC2 0.918280909791707 1.39168306854263e-14 -1.25486248564221 0.000172992176354394 MirTarget -0.479425009930687 6.21849237210953e-05 NA NA NA hsa-miR-7-1-3p NFATC2 1.13646121619622 1.49823237535933e-14 -1.25486248564221 0.000172992176354394 mirMAP -0.437536024803867 5.31776518083098e-06 NA NA NA hsa-miR-9-5p NFATC2 1.65694862043766 2.08325802567323e-05 -1.25486248564221 0.000172992176354394 MirTarget -0.188930767530834 3.12605846928591e-07 NA NA NA hsa-miR-15b-3p NFATC4 1.05020782493504 6.38723677324836e-14 0.415879415068961 0.0231544563160674 mirMAP -0.308042115025679 2.37467711881828e-08 NA NA NA hsa-miR-193a-3p NFATC4 0.22120710726779 0.111827069464729 0.415879415068961 0.0231544563160674 miRanda -0.170575117609832 0.00306091588712347 NA NA NA hsa-miR-29a-3p NFATC4 -1.26881270980079 2.82496991513463e-22 0.415879415068961 0.0231544563160674 miRNATAP -0.159786866184639 0.00656637949012794 NA NA NA hsa-miR-429 NFATC4 0.559451508722375 0.00563641638673083 0.415879415068961 0.0231544563160674 miRNATAP -0.191470414872037 9.91379935744975e-07 NA NA NA hsa-miR-629-3p NFATC4 1.43262037314105 2.37092217984413e-19 0.415879415068961 0.0231544563160674 mirMAP -0.22273814727208 3.74632403524541e-06 NA NA NA hsa-miR-15a-5p NFKB1 0.783550182002274 2.60699595655907e-11 -0.0586166405595643 0.532939439102198 miRNAWalker2_validate -0.100524054629175 0.00332260332322556 NA NA NA hsa-let-7c-5p NGF -2.07953368242668 3.46048888391218e-23 1.08938604562817 0.00258107261776762 MirTarget -0.474331709252181 2.09923806999807e-11 NA NA NA hsa-let-7d-5p NGF 0.481757661442508 3.66030810124939e-07 1.08938604562817 0.00258107261776762 MirTarget -0.66981065797809 5.57819243832775e-05 NA NA NA hsa-let-7g-5p NGF -0.250780249469264 0.00939610188330072 1.08938604562817 0.00258107261776762 MirTarget -1.0538459376691 8.8206138464407e-11 NA NA NA hsa-miR-320a NGF 0.801356001806321 4.91397101474502e-09 1.08938604562817 0.00258107261776762 miRanda -0.394376196453096 0.000532905541066623 NA NA NA hsa-miR-320b NGF 1.23473838180754 3.04337566045537e-14 1.08938604562817 0.00258107261776762 miRanda -0.4625048476379 9.04690456635774e-07 NA NA NA hsa-miR-423-5p NGF 0.60141781325829 1.62940950644999e-07 1.08938604562817 0.00258107261776762 MirTarget;miRNATAP -0.412248193811393 0.00259074860264355 NA NA NA hsa-miR-429 NGF 0.559451508722375 0.00563641638673083 1.08938604562817 0.00258107261776762 miRanda -0.479244868905427 4.56216629494526e-10 NA NA NA hsa-let-7a-5p NLK -0.439381775414001 3.1119785480023e-05 0.332302579249867 3.71291935203561e-07 TargetScan;miRNATAP -0.123649485141098 4.67770623394563e-06 NA NA NA hsa-let-7b-5p NLK -0.2489842756826 0.0211384499461719 0.332302579249867 3.71291935203561e-07 miRNATAP -0.115035305955481 1.46799264825039e-05 NA NA NA hsa-miR-324-5p NR4A1 1.66709479707179 1.45961450445769e-23 -1.47482767400841 6.55750227177689e-10 miRanda -0.163367847815031 0.00718489179540941 NA NA NA hsa-miR-145-5p NRAS -0.46917511594055 0.000685297625493134 0.398384760345124 2.73206950817875e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.127512559718541 2.02648627117484e-05 26973415 miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend colon cancer hsa-miR-195-3p NRAS -0.624259620429699 0.000164279659144497 0.398384760345124 2.73206950817875e-05 mirMAP -0.105599176842807 2.41335123569666e-05 NA NA NA hsa-miR-26b-5p NRAS -0.254478038884324 0.0285227763044636 0.398384760345124 2.73206950817875e-05 mirMAP;miRNATAP -0.118342937472199 0.000985220833353607 NA NA NA hsa-miR-29b-3p NRAS -0.110721443686039 0.511264554091106 0.398384760345124 2.73206950817875e-05 miRNATAP -0.115340209430372 2.64204854445589e-06 NA NA NA hsa-miR-30e-3p NRAS -0.890635378639789 1.65740480611339e-16 0.398384760345124 2.73206950817875e-05 mirMAP -0.108551838334895 0.00387728250241298 NA NA NA hsa-miR-374a-3p NRAS -0.299190081500425 0.00682975596757891 0.398384760345124 2.73206950817875e-05 miRNATAP -0.154068780755208 4.21664914129326e-05 NA NA NA hsa-miR-374a-5p NRAS -0.621903385111545 6.61791773205282e-12 0.398384760345124 2.73206950817875e-05 mirMAP -0.130523090756999 0.00410722859636246 NA NA NA hsa-miR-374b-5p NRAS -0.288413933608091 0.0041474558664058 0.398384760345124 2.73206950817875e-05 mirMAP -0.269889320734344 4.1936925860835e-11 NA NA NA hsa-miR-664a-3p NRAS -0.256108763664991 0.0513188660751664 0.398384760345124 2.73206950817875e-05 MirTarget -0.25886236854543 4.55022879480367e-17 NA NA NA hsa-miR-142-3p NTF3 1.12754191614028 1.68798138028946e-08 -2.59170390715855 6.01062258777627e-15 miRanda -0.322747576045281 9.89154762280905e-06 NA NA NA hsa-miR-21-5p NTF3 1.62465922021121 3.44191300985109e-58 -2.59170390715855 6.01062258777627e-15 miRTarBase;miRNATAP -0.943998281374355 2.75568921736203e-13 NA NA NA hsa-miR-221-3p NTF3 0.410625614724387 0.000741090075261272 -2.59170390715855 6.01062258777627e-15 miRNATAP -0.452111562225564 0.000213183149722111 NA NA NA hsa-miR-222-3p NTF3 1.08197052578759 2.32604040301699e-14 -2.59170390715855 6.01062258777627e-15 miRNATAP -0.597619929003425 3.57843462941801e-09 NA NA NA hsa-miR-590-3p NTF3 0.221436901462551 0.0965904764063157 -2.59170390715855 6.01062258777627e-15 miRanda -0.321635739216939 0.00411542175857866 NA NA NA hsa-miR-590-5p NTF3 0.763025362395968 3.65305892505623e-09 -2.59170390715855 6.01062258777627e-15 PITA;miRanda;miRNATAP -0.359406854483493 0.0015720105948893 NA NA NA hsa-miR-125a-3p NTRK2 0.116035800853173 0.444825559956959 -1.11513528054371 0.0139689274900379 miRanda -0.441990373389826 0.000718256641505087 NA NA NA hsa-miR-142-3p NTRK2 1.12754191614028 1.68798138028946e-08 -1.11513528054371 0.0139689274900379 miRanda -0.287360686025783 0.00327565677298023 NA NA NA hsa-miR-142-5p NTRK2 0.288897753038094 0.0900009317815725 -1.11513528054371 0.0139689274900379 mirMAP -0.325271731506136 0.005197294312762 NA NA NA hsa-miR-146b-5p NTRK2 0.917975986853978 3.33749259316025e-09 -1.11513528054371 0.0139689274900379 PITA;miRanda -0.608432796014462 1.1319364914014e-06 NA NA NA hsa-miR-155-5p NTRK2 0.533437622040649 0.00248671179205372 -1.11513528054371 0.0139689274900379 mirMAP -0.290455272050116 0.00960861019429555 NA NA NA hsa-miR-181a-5p NTRK2 0.819060835827404 1.38616688310277e-13 -1.11513528054371 0.0139689274900379 mirMAP -0.631050089356719 0.000320478592136622 NA NA NA hsa-miR-181b-5p NTRK2 0.974255518824355 2.64876280203475e-16 -1.11513528054371 0.0139689274900379 mirMAP -0.988904775119714 6.54840711161066e-10 NA NA NA hsa-miR-186-5p NTRK2 0.353452958261612 0.000145058448579496 -1.11513528054371 0.0139689274900379 mirMAP -1.12885798594687 1.03540888238188e-07 NA NA NA hsa-miR-20a-3p NTRK2 1.34885093664027 2.07697464119202e-12 -1.11513528054371 0.0139689274900379 mirMAP -0.33556158712966 0.000877491532664743 NA NA NA hsa-miR-21-5p NTRK2 1.62465922021121 3.44191300985109e-58 -1.11513528054371 0.0139689274900379 mirMAP -0.5370106860942 0.00223232244493603 NA NA NA hsa-miR-22-3p NTRK2 0.00776313533473072 0.926356548861307 -1.11513528054371 0.0139689274900379 miRNATAP -0.764914528907096 0.00140748708480897 27662840 NTRK2 is an oncogene and associated with microRNA 22 regulation in human gastric cancer cell lines; The upstream regulator of NTRK2 microRNA-22 miR-22 was evaluated by dual-luciferase assay; In miR-22-upregulated MKN-28 and SNU-719 cells NTRK2 was further overexpressed to evaluate functional interaction between miR-22 and NTRK2 in GC; MiR-22 was verified to be an inverse upstream regulator of NTRK2; NTRK2 is an oncogene and reversely associated with miR-22 in regulating in vitro cancer development in GC gastric cancer hsa-miR-299-5p NTRK2 -1.92445654064493 1.52402531359074e-16 -1.11513528054371 0.0139689274900379 PITA -0.280431233884042 0.000676602024362476 NA NA NA hsa-miR-29a-5p NTRK2 0.323252792625584 0.0370417231222825 -1.11513528054371 0.0139689274900379 mirMAP -0.622411811466971 9.52438364565386e-07 NA NA NA hsa-miR-301a-3p NTRK2 2.14132004241926 4.46255413526808e-25 -1.11513528054371 0.0139689274900379 mirMAP -0.41370094338822 4.90974280092853e-06 NA NA NA hsa-miR-330-5p NTRK2 0.944693925383906 5.04972895657346e-13 -1.11513528054371 0.0139689274900379 miRanda -0.737054805452755 5.71327871260934e-07 NA NA NA hsa-miR-338-3p NTRK2 -0.948755228846395 8.99167125682392e-08 -1.11513528054371 0.0139689274900379 miRanda -0.533792504538669 1.09591550522627e-06 NA NA NA hsa-miR-339-5p NTRK2 1.07771430326938 2.45772601859307e-09 -1.11513528054371 0.0139689274900379 miRanda -0.278714184510507 0.00991541876007542 NA NA NA hsa-miR-342-3p NTRK2 0.99756868977753 9.28499866272332e-10 -1.11513528054371 0.0139689274900379 miRanda -0.532338738427602 7.79883630091174e-06 NA NA NA hsa-miR-452-3p NTRK2 1.09618110917892 2.21867884261816e-07 -1.11513528054371 0.0139689274900379 mirMAP -0.260313701493982 0.00489780827399834 NA NA NA hsa-miR-454-3p NTRK2 1.54137391927201 4.15861570449376e-20 -1.11513528054371 0.0139689274900379 mirMAP -0.504437015123473 8.16691472054223e-06 NA NA NA hsa-miR-455-3p NTRK2 2.68574446868387 4.28975903022818e-42 -1.11513528054371 0.0139689274900379 mirMAP -0.525066893090797 8.16274777713328e-09 NA NA NA hsa-miR-501-5p NTRK2 1.02806906860218 1.63456814370548e-09 -1.11513528054371 0.0139689274900379 mirMAP -0.378256345060406 0.00110146255037686 NA NA NA hsa-miR-576-5p NTRK2 0.940432050128373 6.90227595663302e-12 -1.11513528054371 0.0139689274900379 PITA;mirMAP -1.01793683008079 2.36682358426359e-13 NA NA NA hsa-miR-590-3p NTRK2 0.221436901462551 0.0965904764063157 -1.11513528054371 0.0139689274900379 PITA;miRanda;mirMAP -0.390843032150866 0.00886155311856371 NA NA NA hsa-miR-199a-5p PAK1 -0.364835768178638 0.0435119211101981 0.447978132304134 0.000120547414290664 miRanda -0.109400729243876 9.99089479586017e-05 NA NA NA hsa-miR-126-5p PAK2 -0.953529188793816 7.91719143295591e-16 0.649063820150968 2.23057345388133e-14 mirMAP -0.111227265584047 0.000363748334018261 NA NA NA hsa-miR-139-5p PAK2 -1.46099200329485 7.85040381494472e-22 0.649063820150968 2.23057345388133e-14 MirTarget;miRanda -0.172232009258379 1.90973137140248e-13 NA NA NA hsa-miR-140-3p PAK2 -0.967453553824782 7.6999446305445e-23 0.649063820150968 2.23057345388133e-14 MirTarget;PITA;miRNATAP -0.141733700937119 0.000133602038061862 NA NA NA hsa-miR-26b-5p PAK2 -0.254478038884324 0.0285227763044636 0.649063820150968 2.23057345388133e-14 MirTarget;mirMAP;miRNATAP -0.195131754336615 1.62377771314848e-09 NA NA NA hsa-miR-362-3p PAK2 -0.697212068252854 2.61718493418184e-06 0.649063820150968 2.23057345388133e-14 miRanda -0.131685946445111 1.8289272374813e-07 NA NA NA hsa-miR-500a-3p PAK2 0.457959128173392 0.000691656736597067 0.649063820150968 2.23057345388133e-14 miRNAWalker2_validate -0.116224960974462 3.19506862362859e-05 NA NA NA hsa-miR-26b-5p PDGFB -0.254478038884324 0.0285227763044636 0.845464958577077 8.67485169100214e-08 miRNAWalker2_validate -0.172324630804419 0.00423712529201602 NA NA NA hsa-miR-29b-2-5p PDGFB -0.502720326849742 0.000730448246894952 0.845464958577077 8.67485169100214e-08 mirMAP -0.266903581406135 7.38754988734083e-09 NA NA NA hsa-miR-29b-3p PDGFB -0.110721443686039 0.511264554091106 0.845464958577077 8.67485169100214e-08 MirTarget;miRNATAP -0.160863843240162 9.73115177806472e-05 NA NA NA hsa-miR-29c-3p PDGFB -2.08166260448948 8.3238369390898e-24 0.845464958577077 8.67485169100214e-08 MirTarget;miRNATAP -0.164724591746529 2.30913539327549e-07 NA NA NA hsa-miR-342-3p PDGFB 0.99756868977753 9.28499866272332e-10 0.845464958577077 8.67485169100214e-08 miRanda -0.177362693333945 2.31239920349643e-05 NA NA NA hsa-let-7a-3p PDGFRA 0.0966652362351867 0.423761916840503 -0.463142743937045 0.04817832252781 mirMAP -0.529669602176716 2.68390850522982e-10 NA NA NA hsa-let-7f-1-3p PDGFRA 0.700374242293247 8.65000484720084e-08 -0.463142743937045 0.04817832252781 mirMAP -0.203048287649371 0.00882303668338635 NA NA NA hsa-let-7g-3p PDGFRA 0.637019243992294 0.000204623048574065 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.242214636780195 4.14305980343687e-05 NA NA NA hsa-miR-106a-5p PDGFRA 0.67978010057847 0.00221925869726092 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.187108191561856 4.125997505122e-05 NA NA NA hsa-miR-106b-5p PDGFRA 0.50378717276868 1.45412404526866e-05 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.279116396967218 0.00146889907846801 NA NA NA hsa-miR-130a-3p PDGFRA 0.67051191119964 4.89747518735144e-06 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.515723307874652 2.38971422139082e-14 NA NA NA hsa-miR-141-3p PDGFRA 0.730011517758706 0.000120338355004032 -0.463142743937045 0.04817832252781 MirTarget -0.505767490532425 6.91381154503213e-23 NA NA NA hsa-miR-149-5p PDGFRA 0.443278770827687 0.0642022866136881 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.173776938709491 4.23057230524602e-05 NA NA NA hsa-miR-16-1-3p PDGFRA 0.955017760172879 5.95379292601146e-11 -0.463142743937045 0.04817832252781 MirTarget -0.394960139372927 7.06855621054673e-09 NA NA NA hsa-miR-17-5p PDGFRA 1.41924888736771 2.75805544953758e-18 -0.463142743937045 0.04817832252781 MirTarget;TargetScan;miRNATAP -0.486966289383704 1.65975367184753e-16 NA NA NA hsa-miR-182-5p PDGFRA 1.15060905311096 6.25565852529946e-10 -0.463142743937045 0.04817832252781 miRNATAP -0.251226400702905 2.8736296191221e-06 NA NA NA hsa-miR-186-5p PDGFRA 0.353452958261612 0.000145058448579496 -0.463142743937045 0.04817832252781 MirTarget -0.430638628510272 9.25678657223338e-05 NA NA NA hsa-miR-193a-3p PDGFRA 0.22120710726779 0.111827069464729 -0.463142743937045 0.04817832252781 miRanda -0.385360637474971 1.31801900899795e-07 NA NA NA hsa-miR-196b-5p PDGFRA 3.78958266598891 1.12771732893771e-44 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.141611620840498 3.83240889487933e-05 NA NA NA hsa-miR-200a-3p PDGFRA 0.607140814457753 0.00289840524858752 -0.463142743937045 0.04817832252781 MirTarget -0.418556109432712 5.5401611171402e-18 NA NA NA hsa-miR-20a-5p PDGFRA 1.1531986665452 1.02385132917958e-11 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.459634108198747 1.4648906334426e-15 NA NA NA hsa-miR-224-5p PDGFRA 1.94534596857416 1.88348779207332e-19 -0.463142743937045 0.04817832252781 MirTarget -0.291603637702123 8.45665637241549e-11 NA NA NA hsa-miR-26b-5p PDGFRA -0.254478038884324 0.0285227763044636 -0.463142743937045 0.04817832252781 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.29571434460346 0.000811001382839524 NA NA NA hsa-miR-27a-3p PDGFRA 0.348456440505425 0.00126682892514312 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.399431408470765 2.36940280836809e-05 NA NA NA hsa-miR-29b-1-5p PDGFRA 1.39669186711325 4.36960953138935e-11 -0.463142743937045 0.04817832252781 mirMAP -0.310505328638843 2.6214579770892e-11 NA NA NA hsa-miR-29b-3p PDGFRA -0.110721443686039 0.511264554091106 -0.463142743937045 0.04817832252781 MirTarget -0.309199593590445 2.87491088364754e-07 NA NA NA hsa-miR-301a-3p PDGFRA 2.14132004241926 4.46255413526808e-25 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.30716680230266 2.9839566707638e-11 NA NA NA hsa-miR-320a PDGFRA 0.801356001806321 4.91397101474502e-09 -0.463142743937045 0.04817832252781 miRanda -0.256088551213152 0.000504831123583266 NA NA NA hsa-miR-320b PDGFRA 1.23473838180754 3.04337566045537e-14 -0.463142743937045 0.04817832252781 miRanda -0.236668681167249 0.000109090155715803 NA NA NA hsa-miR-330-5p PDGFRA 0.944693925383906 5.04972895657346e-13 -0.463142743937045 0.04817832252781 miRanda -0.214351710717381 0.00518115566688398 NA NA NA hsa-miR-338-3p PDGFRA -0.948755228846395 8.99167125682392e-08 -0.463142743937045 0.04817832252781 miRanda -0.159079633123343 0.00521295319497949 NA NA NA hsa-miR-339-5p PDGFRA 1.07771430326938 2.45772601859307e-09 -0.463142743937045 0.04817832252781 miRanda -0.412211810143285 3.68470566893721e-14 NA NA NA hsa-miR-33a-5p PDGFRA 1.12988965056352 3.35742517382153e-07 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.295170225755906 4.71759962730372e-11 NA NA NA hsa-miR-33b-5p PDGFRA 0.681845193600723 0.00407790722487864 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.237387453331384 5.90803903406106e-08 NA NA NA hsa-miR-342-3p PDGFRA 0.99756868977753 9.28499866272332e-10 -0.463142743937045 0.04817832252781 MirTarget;miRanda;miRNATAP -0.201117464069554 0.0011186847998832 NA NA NA hsa-miR-34a-5p PDGFRA -0.117372471043915 0.364001947180738 -0.463142743937045 0.04817832252781 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.279473416683797 0.000425575449508612 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network glioblastoma hsa-miR-429 PDGFRA 0.559451508722375 0.00563641638673083 -0.463142743937045 0.04817832252781 miRanda;miRNATAP -0.3646603274658 1.47498623679927e-13 NA NA NA hsa-miR-454-3p PDGFRA 1.54137391927201 4.15861570449376e-20 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.406092239175468 1.67299803475594e-12 NA NA NA hsa-miR-455-5p PDGFRA 1.408595672323 5.52039116456697e-22 -0.463142743937045 0.04817832252781 MirTarget;PITA;miRanda -0.261429891373877 9.49351636713376e-05 NA NA NA hsa-miR-576-5p PDGFRA 0.940432050128373 6.90227595663302e-12 -0.463142743937045 0.04817832252781 mirMAP -0.48252244916662 2.04399434436523e-11 NA NA NA hsa-miR-589-3p PDGFRA 1.59559692667315 6.2886410639161e-15 -0.463142743937045 0.04817832252781 mirMAP -0.333031429734795 2.20227456353819e-11 NA NA NA hsa-miR-590-3p PDGFRA 0.221436901462551 0.0965904764063157 -0.463142743937045 0.04817832252781 miRanda;mirMAP -0.363428459817233 2.01021651672196e-06 NA NA NA hsa-miR-590-5p PDGFRA 0.763025362395968 3.65305892505623e-09 -0.463142743937045 0.04817832252781 miRanda -0.630471151401988 1.02894688811306e-16 NA NA NA hsa-miR-7-1-3p PDGFRA 1.13646121619622 1.49823237535933e-14 -0.463142743937045 0.04817832252781 mirMAP -0.470693839225208 1.10880684128766e-12 NA NA NA hsa-miR-93-5p PDGFRA 1.61042951896619 5.1280369606967e-24 -0.463142743937045 0.04817832252781 MirTarget;miRNATAP -0.345803927630158 1.16570780178394e-08 NA NA NA hsa-miR-944 PDGFRA 1.47323925060177 2.61626403984929e-13 -0.463142743937045 0.04817832252781 mirMAP -0.182467322614544 0.000220849656173125 NA NA NA hsa-miR-96-5p PDGFRA 1.42326703011157 4.39736150032373e-14 -0.463142743937045 0.04817832252781 TargetScan;miRNATAP -0.373700371207876 5.21978290236253e-13 NA NA NA hsa-miR-29a-3p PDGFRB -1.26881270980079 2.82496991513463e-22 1.61349776863339 3.00832890375111e-14 miRNATAP -0.252848924108258 0.0002864380072827 NA NA NA hsa-miR-29b-3p PDGFRB -0.110721443686039 0.511264554091106 1.61349776863339 3.00832890375111e-14 miRNATAP -0.381814573387718 5.66152644629818e-12 NA NA NA hsa-miR-29c-3p PDGFRB -2.08166260448948 8.3238369390898e-24 1.61349776863339 3.00832890375111e-14 miRNATAP -0.230825030507139 1.04275605654934e-07 NA NA NA hsa-miR-338-3p PDGFRB -0.948755228846395 8.99167125682392e-08 1.61349776863339 3.00832890375111e-14 miRanda -0.2824081657779 6.98566776548666e-08 NA NA NA hsa-miR-34a-5p PDGFRB -0.117372471043915 0.364001947180738 1.61349776863339 3.00832890375111e-14 MirTarget -0.416833898128444 1.12557808434585e-08 24837198 MicroRNA 34A inhibits the growth invasion and metastasis of gastric cancer by targeting PDGFR and MET expression; In this study our aim was to identify the miRNAs that target PDGFR-α/β and to study the functions of these miRNAs miR-34a was predicted to target PDGFR and luciferase reporter assays showed that miR-34a could directly target PDGFR; Moreover the cancer-associated cell signalling pathway was studied and we found that miR-34a could inhibit Akt PKB protein kinase B phosphorylation which was restored by the overexpression of both PDGFR and MET; In conclusion miR-34a may act as a potential tumour suppressor in gastric cancer and is associated with the mechanisms of gastric cancer metastasis; miR-34a can inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K phosphoinositide 3-kinase/Akt pathway metastasis gastric cancer hsa-miR-361-3p PDGFRB 0.272298288982435 0.0147874880476998 1.61349776863339 3.00832890375111e-14 MirTarget -0.245649935526185 0.00405851316554908 NA NA NA hsa-miR-664a-3p PDGFRB -0.256108763664991 0.0513188660751664 1.61349776863339 3.00832890375111e-14 MirTarget -0.201316703730783 0.00552266661901063 NA NA NA hsa-miR-9-5p PDGFRB 1.65694862043766 2.08325802567323e-05 1.61349776863339 3.00832890375111e-14 MirTarget;miRNATAP -0.101903933904259 2.25485460574598e-05 NA NA NA hsa-miR-106b-5p PLA2G12A 0.50378717276868 1.45412404526866e-05 -0.773329107391423 2.43200915974282e-25 mirMAP -0.113152221403065 9.71366002804154e-05 NA NA NA hsa-miR-142-3p PLA2G12A 1.12754191614028 1.68798138028946e-08 -0.773329107391423 2.43200915974282e-25 miRanda -0.104413909705145 2.31791164239698e-10 NA NA NA hsa-miR-16-2-3p PLA2G12A 1.1567130855258 1.01867256952189e-14 -0.773329107391423 2.43200915974282e-25 mirMAP -0.127091654598804 6.02628463819818e-09 NA NA NA hsa-miR-181a-5p PLA2G12A 0.819060835827404 1.38616688310277e-13 -0.773329107391423 2.43200915974282e-25 mirMAP -0.177084446294844 2.45134089240318e-09 NA NA NA hsa-miR-181b-5p PLA2G12A 0.974255518824355 2.64876280203475e-16 -0.773329107391423 2.43200915974282e-25 mirMAP -0.16275276376844 2.98535886245717e-09 NA NA NA hsa-miR-625-3p PLA2G12A 0.0858338965684338 0.484971431380441 -0.773329107391423 2.43200915974282e-25 mirMAP -0.126989161560015 4.13953749944208e-06 NA NA NA hsa-miR-361-5p PLA2G2A 0.0803683277369505 0.314043140368058 -5.07596668469226 1.66171761681806e-23 miRanda -0.781056988805095 0.00829293149597172 NA NA NA hsa-miR-338-3p PLA2G2D -0.948755228846395 8.99167125682392e-08 1.06272215329204 0.0205348409418983 mirMAP -0.459956147027393 3.45885213943891e-05 NA NA NA hsa-miR-432-5p PLA2G2D -1.37745409934142 1.95995628572162e-09 1.06272215329204 0.0205348409418983 mirMAP -0.321939313285914 0.000173473611383924 NA NA NA hsa-miR-542-3p PLA2G2D 0.643308814904977 8.81635403230104e-07 1.06272215329204 0.0205348409418983 mirMAP -0.424558686560124 0.00526558318994375 NA NA NA hsa-miR-107 PLA2G2F -0.0447040564279497 0.671618791096755 2.39159167905521 3.03321604447909e-06 miRNATAP -1.22281290549308 9.80852928367302e-09 NA NA NA hsa-miR-125b-5p PLA2G2F -0.993460109818276 5.07736727659894e-12 2.39159167905521 3.03321604447909e-06 mirMAP -1.07055494180228 1.2079180661789e-12 NA NA NA hsa-miR-219a-1-3p PLA2G2F 0.54812960890496 0.000643480374673536 2.39159167905521 3.03321604447909e-06 MirTarget -0.816812716298986 3.53248750025489e-09 NA NA NA hsa-miR-296-5p PLA2G2F -0.425442682383961 0.0948240114267711 2.39159167905521 3.03321604447909e-06 mirMAP -0.40234344693344 7.84747912448152e-06 NA NA NA hsa-miR-324-3p PLA2G2F 0.867391246413545 3.63808540490361e-10 2.39159167905521 3.03321604447909e-06 mirMAP -0.722884962070708 5.97679176707774e-06 NA NA NA hsa-miR-326 PLA2G2F -0.425943992128769 0.0415010315530797 2.39159167905521 3.03321604447909e-06 mirMAP -0.292944760152887 0.00680257166363506 NA NA NA hsa-miR-335-5p PLA2G2F -1.17227779671552 1.49282618530733e-10 2.39159167905521 3.03321604447909e-06 mirMAP -0.745274230846876 4.10351967835558e-10 NA NA NA hsa-miR-532-5p PLA2G2F -0.021857649390892 0.830992272120134 2.39159167905521 3.03321604447909e-06 mirMAP -0.982413216365621 8.88844541055468e-06 NA NA NA hsa-let-7d-5p PLA2G3 0.481757661442508 3.66030810124939e-07 -1.55144754456764 0.000892530659625258 MirTarget -0.791725977061563 0.000234227869408305 NA NA NA hsa-let-7e-5p PLA2G3 0.0857356192778891 0.512869729833211 -1.55144754456764 0.000892530659625258 MirTarget -0.954528348111551 6.67534191858455e-10 NA NA NA hsa-let-7i-5p PLA2G3 0.249440992451337 0.00426823922424972 -1.55144754456764 0.000892530659625258 MirTarget -0.634764626341883 0.00737002608471883 NA NA NA hsa-miR-125a-3p PLA2G3 0.116035800853173 0.444825559956959 -1.55144754456764 0.000892530659625258 miRanda;miRNATAP -0.629027586265024 2.74387066358586e-06 NA NA NA hsa-miR-214-3p PLA2G3 -0.118240959890965 0.564962359782563 -1.55144754456764 0.000892530659625258 MirTarget -0.318860501519846 0.00137931064400643 NA NA NA hsa-miR-323a-3p PLA2G3 0.554923914792824 0.00856909375866133 -1.55144754456764 0.000892530659625258 MirTarget -0.453421691338451 3.55310724475585e-06 NA NA NA hsa-miR-450b-5p PLA2G3 1.25529820885833 1.18847120528666e-15 -1.55144754456764 0.000892530659625258 miRNATAP -0.797130129847432 1.75318622944739e-10 NA NA NA hsa-miR-877-5p PLA2G3 1.97571572671705 2.0032239372269e-19 -1.55144754456764 0.000892530659625258 MirTarget -0.394189129388487 4.50358237517234e-05 NA NA NA hsa-miR-146b-5p PLA2G4A 0.917975986853978 3.33749259316025e-09 -0.460609969941168 0.089725403121305 miRNAWalker2_validate -0.312706384274956 2.97197899139276e-05 NA NA NA hsa-miR-181a-5p PLA2G4A 0.819060835827404 1.38616688310277e-13 -0.460609969941168 0.089725403121305 MirTarget -0.343622076779683 0.00104992726574145 NA NA NA hsa-miR-181b-5p PLA2G4A 0.974255518824355 2.64876280203475e-16 -0.460609969941168 0.089725403121305 MirTarget -0.301620745034892 0.00186067356352167 NA NA NA hsa-miR-432-5p PLA2G4E -1.37745409934142 1.95995628572162e-09 0.42032711661257 0.3709136444725 mirMAP -0.263208864952446 0.00272460058896533 NA NA NA hsa-miR-664a-3p PLA2G4E -0.256108763664991 0.0513188660751664 0.42032711661257 0.3709136444725 mirMAP -0.826986198627894 9.10088489695046e-08 NA NA NA hsa-miR-330-5p PLA2G5 0.944693925383906 5.04972895657346e-13 -0.467636358747842 0.0620719799293586 miRanda -0.257302280936903 0.00167841807610569 NA NA NA hsa-miR-339-5p PLA2G5 1.07771430326938 2.45772601859307e-09 -0.467636358747842 0.0620719799293586 miRanda -0.268456976521455 5.82075902949895e-06 NA NA NA hsa-miR-429 PLA2G5 0.559451508722375 0.00563641638673083 -0.467636358747842 0.0620719799293586 miRanda -0.290029978513431 5.55947010592671e-08 NA NA NA hsa-miR-589-3p PLA2G5 1.59559692667315 6.2886410639161e-15 -0.467636358747842 0.0620719799293586 MirTarget -0.19760724002258 0.000253067536702086 NA NA NA hsa-miR-590-3p PLA2G5 0.221436901462551 0.0965904764063157 -0.467636358747842 0.0620719799293586 miRanda;miRNATAP -0.271782372358567 0.000946830763546805 NA NA NA hsa-miR-590-5p PLA2G5 0.763025362395968 3.65305892505623e-09 -0.467636358747842 0.0620719799293586 miRanda -0.438011814247796 1.21396823094669e-07 NA NA NA hsa-miR-185-3p PLA2G6 0.653637407906201 6.54212996668668e-05 -0.1388448067516 0.262127145301077 MirTarget -0.101887125819572 0.00185902800489636 NA NA NA hsa-miR-2355-3p PLA2G6 1.58434563546762 4.06578912176206e-18 -0.1388448067516 0.262127145301077 MirTarget -0.168200890698393 2.27529266289357e-09 NA NA NA hsa-miR-106b-5p PPM1A 0.50378717276868 1.45412404526866e-05 -0.323626153339578 5.90595010125973e-07 mirMAP -0.10200128774818 2.61518274615619e-05 NA NA NA hsa-miR-146b-3p PPM1A 0.186534815310862 0.169137114997759 -0.323626153339578 5.90595010125973e-07 miRNATAP -0.102264672136973 9.14359542648228e-07 NA NA NA hsa-miR-146b-5p PPM1A 0.917975986853978 3.33749259316025e-09 -0.323626153339578 5.90595010125973e-07 miRanda;miRNATAP -0.108894805379896 9.06871122314677e-10 NA NA NA hsa-miR-15a-5p PPM1A 0.783550182002274 2.60699595655907e-11 -0.323626153339578 5.90595010125973e-07 MirTarget;miRNATAP -0.137318850718232 5.14934238408986e-09 NA NA NA hsa-miR-16-1-3p PPM1A 0.955017760172879 5.95379292601146e-11 -0.323626153339578 5.90595010125973e-07 mirMAP -0.111724636569952 3.50008224146065e-09 NA NA NA hsa-miR-16-5p PPM1A 0.521122945828175 1.40561786410572e-06 -0.323626153339578 5.90595010125973e-07 MirTarget;miRNATAP -0.107677806599285 3.66391651345128e-05 NA NA NA hsa-miR-186-5p PPM1A 0.353452958261612 0.000145058448579496 -0.323626153339578 5.90595010125973e-07 mirMAP;miRNATAP -0.172994846692321 1.15069379572036e-08 NA NA NA hsa-miR-26b-5p PPM1A -0.254478038884324 0.0285227763044636 -0.323626153339578 5.90595010125973e-07 mirMAP -0.101260563520694 3.3974056217732e-05 NA NA NA hsa-miR-28-3p PPM1A 0.459875450032895 3.47095927872566e-07 -0.323626153339578 5.90595010125973e-07 miRNATAP -0.134231714093188 1.81426481314603e-05 NA NA NA hsa-miR-34a-5p PPM1A -0.117372471043915 0.364001947180738 -0.323626153339578 5.90595010125973e-07 miRNATAP -0.115699027529835 1.17705933482343e-07 NA NA NA hsa-miR-7-1-3p PPM1A 1.13646121619622 1.49823237535933e-14 -0.323626153339578 5.90595010125973e-07 mirMAP -0.103705868211761 2.14749277179153e-08 NA NA NA hsa-miR-181a-5p PPM1B 0.819060835827404 1.38616688310277e-13 -0.372675448759314 1.27435501979867e-07 mirMAP;miRNATAP -0.140263276297307 2.58140243704531e-07 NA NA NA hsa-miR-181b-5p PPM1B 0.974255518824355 2.64876280203475e-16 -0.372675448759314 1.27435501979867e-07 mirMAP;miRNATAP -0.200482322721441 4.67447160782225e-16 NA NA NA hsa-miR-542-3p PPM1B 0.643308814904977 8.81635403230104e-07 -0.372675448759314 1.27435501979867e-07 miRanda -0.123479864041116 1.14656328796655e-07 NA NA NA hsa-let-7g-5p PPP3CA -0.250780249469264 0.00939610188330072 0.0261166441094005 0.774380327390763 miRNATAP -0.129044274233211 0.00176768769369972 NA NA NA hsa-miR-17-5p PPP3CA 1.41924888736771 2.75805544953758e-18 0.0261166441094005 0.774380327390763 miRNATAP -0.107154786794133 4.49246161780872e-06 NA NA NA hsa-miR-186-5p PPP3CA 0.353452958261612 0.000145058448579496 0.0261166441094005 0.774380327390763 mirMAP -0.119442984122439 0.00521905941342711 NA NA NA hsa-miR-194-5p PPP3CA -0.0214221838459805 0.872940154118701 0.0261166441094005 0.774380327390763 MirTarget -0.227106380168213 4.11707254283389e-15 NA NA NA hsa-miR-20a-5p PPP3CA 1.1531986665452 1.02385132917958e-11 0.0261166441094005 0.774380327390763 miRNATAP -0.135937480891387 1.71175203332467e-09 NA NA NA hsa-miR-30c-5p PPP3CA 0.021222006155897 0.886366656528128 0.0261166441094005 0.774380327390763 miRNATAP -0.138568670147619 1.67033051966156e-07 NA NA NA hsa-miR-30d-5p PPP3CA -0.38399848121878 0.000171129616944749 0.0261166441094005 0.774380327390763 miRNATAP -0.103928901064269 0.00747324777039719 NA NA NA hsa-miR-361-3p PPP3CA 0.272298288982435 0.0147874880476998 0.0261166441094005 0.774380327390763 MirTarget;PITA;miRNATAP -0.147461540913571 3.1572107642519e-05 NA NA NA hsa-miR-590-3p PPP3CA 0.221436901462551 0.0965904764063157 0.0261166441094005 0.774380327390763 miRanda;mirMAP -0.1292662240092 1.28492091373993e-05 NA NA NA hsa-miR-590-5p PPP3CA 0.763025362395968 3.65305892505623e-09 0.0261166441094005 0.774380327390763 PITA;miRanda;miRNATAP -0.130608084993601 1.4121892378982e-05 NA NA NA hsa-miR-664a-3p PPP3CA -0.256108763664991 0.0513188660751664 0.0261166441094005 0.774380327390763 mirMAP -0.154862721187903 2.28408619679922e-07 NA NA NA hsa-miR-7-1-3p PPP3CA 1.13646121619622 1.49823237535933e-14 0.0261166441094005 0.774380327390763 MirTarget;mirMAP -0.113744929124115 1.18665245144482e-05 NA NA NA hsa-miR-93-5p PPP3CA 1.61042951896619 5.1280369606967e-24 0.0261166441094005 0.774380327390763 miRNATAP -0.134887598190219 8.69707313946358e-09 NA NA NA hsa-miR-96-5p PPP3CA 1.42326703011157 4.39736150032373e-14 0.0261166441094005 0.774380327390763 TargetScan -0.105360576077386 1.99204409171748e-07 NA NA NA hsa-miR-15b-5p PPP3CB 0.85315666454713 3.79816274836297e-12 -0.430650123435909 1.6653183674225e-09 miRNATAP -0.147896038786253 2.77153942258358e-09 NA NA NA hsa-miR-361-5p PPP3CB 0.0803683277369505 0.314043140368058 -0.430650123435909 1.6653183674225e-09 miRanda -0.146324240065503 0.000258725360624939 NA NA NA hsa-miR-429 PPP3CB 0.559451508722375 0.00563641638673083 -0.430650123435909 1.6653183674225e-09 miRanda -0.126839398598655 4.12587575752935e-17 NA NA NA hsa-let-7a-3p PRKACB 0.0966652362351867 0.423761916840503 -0.321098607006344 0.0228761424530327 MirTarget;mirMAP;miRNATAP -0.24351006648709 1.69808754515966e-06 NA NA NA hsa-let-7d-3p PRKACB 0.770676758773193 9.57945374997326e-13 -0.321098607006344 0.0228761424530327 MirTarget -0.261113668353957 2.78655698859518e-06 NA NA NA hsa-miR-141-3p PRKACB 0.730011517758706 0.000120338355004032 -0.321098607006344 0.0228761424530327 MirTarget;TargetScan;miRNATAP -0.267679710851304 1.06126331262823e-17 NA NA NA hsa-miR-16-2-3p PRKACB 1.1567130855258 1.01867256952189e-14 -0.321098607006344 0.0228761424530327 mirMAP -0.25465198696094 1.15210482297961e-10 NA NA NA hsa-miR-17-5p PRKACB 1.41924888736771 2.75805544953758e-18 -0.321098607006344 0.0228761424530327 TargetScan -0.320719783263986 1.04231465157064e-19 NA NA NA hsa-miR-182-5p PRKACB 1.15060905311096 6.25565852529946e-10 -0.321098607006344 0.0228761424530327 MirTarget;miRNATAP -0.192126378855167 2.14564015173888e-09 NA NA NA hsa-miR-183-5p PRKACB 1.4313129319945 6.25230916431996e-14 -0.321098607006344 0.0228761424530327 MirTarget -0.193043292756991 4.67956422537156e-10 NA NA NA hsa-miR-18a-5p PRKACB 1.65455873230328 3.76457892277775e-20 -0.321098607006344 0.0228761424530327 miRNATAP -0.281434127350525 9.68681768909003e-19 NA NA NA hsa-miR-193a-3p PRKACB 0.22120710726779 0.111827069464729 -0.321098607006344 0.0228761424530327 miRanda -0.120890648652317 0.00645270297281106 NA NA NA hsa-miR-19a-3p PRKACB 1.35800152353624 2.80940447111944e-12 -0.321098607006344 0.0228761424530327 MirTarget;miRNATAP -0.258968002486092 6.18986461469059e-18 NA NA NA hsa-miR-19b-3p PRKACB 0.538732279378089 0.000622008277870679 -0.321098607006344 0.0228761424530327 miRNAWalker2_validate;MirTarget;miRNATAP -0.335571469796732 5.37740203716601e-19 NA NA NA hsa-miR-200a-3p PRKACB 0.607140814457753 0.00289840524858752 -0.321098607006344 0.0228761424530327 MirTarget;miRNATAP -0.241062026533704 1.65937825863575e-16 NA NA NA hsa-miR-200b-3p PRKACB 0.0717138787925347 0.682858087587209 -0.321098607006344 0.0228761424530327 MirTarget;TargetScan -0.231640096513903 1.90730092010153e-11 NA NA NA hsa-miR-200c-3p PRKACB 0.630251054099546 0.000131975031451555 -0.321098607006344 0.0228761424530327 MirTarget;miRNATAP -0.209750443181332 1.11607954800956e-08 NA NA NA hsa-miR-30d-3p PRKACB -0.577371911152798 2.02950840095287e-06 -0.321098607006344 0.0228761424530327 mirMAP -0.229710131067783 4.74198208250703e-06 NA NA NA hsa-miR-339-5p PRKACB 1.07771430326938 2.45772601859307e-09 -0.321098607006344 0.0228761424530327 miRanda -0.226395664639244 6.08522673686748e-12 NA NA NA hsa-miR-34a-5p PRKACB -0.117372471043915 0.364001947180738 -0.321098607006344 0.0228761424530327 miRNATAP -0.188258649958631 7.8062126512609e-05 NA NA NA hsa-miR-362-5p PRKACB 0.41089772861323 0.0404254902071382 -0.321098607006344 0.0228761424530327 PITA -0.231677226283398 9.49014505345782e-15 NA NA NA hsa-miR-429 PRKACB 0.559451508722375 0.00563641638673083 -0.321098607006344 0.0228761424530327 MirTarget;PITA;miRanda;miRNATAP -0.24828232747711 3.61288238132463e-17 NA NA NA hsa-miR-532-5p PRKACB -0.021857649390892 0.830992272120134 -0.321098607006344 0.0228761424530327 PITA -0.227164270683247 0.000174154322184187 NA NA NA hsa-miR-590-5p PRKACB 0.763025362395968 3.65305892505623e-09 -0.321098607006344 0.0228761424530327 miRanda -0.305639629088135 3.88857071786905e-11 NA NA NA hsa-miR-7-1-3p PRKACB 1.13646121619622 1.49823237535933e-14 -0.321098607006344 0.0228761424530327 mirMAP -0.163214783006832 5.48095567644113e-05 NA NA NA hsa-miR-708-3p PRKACB 1.32647174389322 4.87465491977979e-16 -0.321098607006344 0.0228761424530327 mirMAP -0.239908721941593 2.49822385276827e-11 NA NA NA hsa-miR-93-5p PRKACB 1.61042951896619 5.1280369606967e-24 -0.321098607006344 0.0228761424530327 miRNAWalker2_validate -0.265261521642743 2.04882387197337e-13 NA NA NA hsa-miR-944 PRKACB 1.47323925060177 2.61626403984929e-13 -0.321098607006344 0.0228761424530327 MirTarget;mirMAP -0.138499316290303 2.90532544481091e-06 NA NA NA hsa-miR-96-5p PRKACB 1.42326703011157 4.39736150032373e-14 -0.321098607006344 0.0228761424530327 miRNATAP -0.258796730941182 5.34409541983872e-17 NA NA NA hsa-miR-103a-2-5p PRKCA 1.37988337975616 6.74852943995612e-08 0.3178322857115 0.0462170958036427 mirMAP -0.117780407567177 5.24493745308123e-05 NA NA NA hsa-miR-150-5p PRKCA -0.243749814009231 0.331546276920338 0.3178322857115 0.0462170958036427 mirMAP -0.104022182991935 0.000162874861270433 NA NA NA hsa-miR-17-3p PRKCA -0.0127974722290336 0.909559935689875 0.3178322857115 0.0462170958036427 miRNAWalker2_validate -0.214761659225552 0.000540115676811066 NA NA NA hsa-miR-181c-5p PRKCA -0.168991199007857 0.196949106150297 0.3178322857115 0.0462170958036427 mirMAP -0.230481828890932 1.38543638100701e-05 NA NA NA hsa-miR-183-5p PRKCA 1.4313129319945 6.25230916431996e-14 0.3178322857115 0.0462170958036427 miRNATAP -0.123604672252822 0.000489233186271866 NA NA NA hsa-miR-186-5p PRKCA 0.353452958261612 0.000145058448579496 0.3178322857115 0.0462170958036427 miRNATAP -0.197395594611936 0.008653002308399 NA NA NA hsa-miR-1976 PRKCA 0.638808083289405 2.94840228896364e-07 0.3178322857115 0.0462170958036427 miRNATAP -0.216146135639291 9.07994360436659e-05 NA NA NA hsa-miR-19b-1-5p PRKCA 0.757034032029085 2.99828133413343e-07 0.3178322857115 0.0462170958036427 mirMAP -0.214408086876696 3.69042545103291e-06 NA NA NA hsa-miR-200b-3p PRKCA 0.0717138787925347 0.682858087587209 0.3178322857115 0.0462170958036427 TargetScan -0.341691724440131 5.17210999735547e-19 NA NA NA hsa-miR-200c-3p PRKCA 0.630251054099546 0.000131975031451555 0.3178322857115 0.0462170958036427 miRNATAP -0.258050454876613 4.38353493232271e-10 NA NA NA hsa-miR-24-2-5p PRKCA 1.27293931700635 4.48240091510596e-15 0.3178322857115 0.0462170958036427 miRNAWalker2_validate -0.121435567912037 0.00357611288622236 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-27b-5p PRKCA 0.580870079022649 0.000181529223377382 0.3178322857115 0.0462170958036427 mirMAP -0.227514723686497 2.70991772299128e-07 NA NA NA hsa-miR-29b-2-5p PRKCA -0.502720326849742 0.000730448246894952 0.3178322857115 0.0462170958036427 mirMAP -0.296683337612196 9.93635847649949e-11 NA NA NA hsa-miR-30d-3p PRKCA -0.577371911152798 2.02950840095287e-06 0.3178322857115 0.0462170958036427 mirMAP -0.332961077885486 3.40360771990262e-09 NA NA NA hsa-miR-30e-3p PRKCA -0.890635378639789 1.65740480611339e-16 0.3178322857115 0.0462170958036427 mirMAP -0.199675307499267 0.00146746163627339 NA NA NA hsa-miR-339-5p PRKCA 1.07771430326938 2.45772601859307e-09 0.3178322857115 0.0462170958036427 mirMAP -0.148559462896231 8.30706937469769e-05 NA NA NA hsa-miR-3607-3p PRKCA 1.01377165357363 9.13355519701165e-05 0.3178322857115 0.0462170958036427 mirMAP -0.133480273866349 4.39877789751401e-07 NA NA NA hsa-miR-362-5p PRKCA 0.41089772861323 0.0404254902071382 0.3178322857115 0.0462170958036427 TargetScan;miRNATAP -0.223333590994173 5.47462768229892e-11 NA NA NA hsa-miR-374a-5p PRKCA -0.621903385111545 6.61791773205282e-12 0.3178322857115 0.0462170958036427 mirMAP -0.205530215602705 0.00688190144820459 NA NA NA hsa-miR-429 PRKCA 0.559451508722375 0.00563641638673083 0.3178322857115 0.0462170958036427 miRanda;miRNATAP -0.266671632635371 1.42360916592268e-15 NA NA NA hsa-miR-500a-5p PRKCA 0.675401699376111 8.24389004707854e-05 0.3178322857115 0.0462170958036427 miRNATAP -0.174713694092824 1.31490069031191e-05 NA NA NA hsa-miR-501-5p PRKCA 1.02806906860218 1.63456814370548e-09 0.3178322857115 0.0462170958036427 miRNATAP -0.164099616970046 5.18294254195767e-05 NA NA NA hsa-miR-505-5p PRKCA 1.25888458076414 7.80089782306577e-13 0.3178322857115 0.0462170958036427 mirMAP -0.108990500629565 0.00483820175668253 NA NA NA hsa-miR-532-3p PRKCA 0.80240056676907 1.08989551712617e-09 0.3178322857115 0.0462170958036427 mirMAP;miRNATAP -0.201724862387695 0.000103690896052721 NA NA NA hsa-miR-590-3p PRKCA 0.221436901462551 0.0965904764063157 0.3178322857115 0.0462170958036427 PITA;miRanda;mirMAP;miRNATAP -0.159630241178647 0.00227859309388304 NA NA NA hsa-miR-92a-3p PRKCA 0.994679542307232 1.32587679156217e-16 0.3178322857115 0.0462170958036427 miRNAWalker2_validate -0.239077901540622 1.99085302915519e-05 NA NA NA hsa-miR-93-3p PRKCA 1.69225547123293 1.50964095575087e-25 0.3178322857115 0.0462170958036427 mirMAP -0.142996896050503 0.000455152507074917 NA NA NA hsa-miR-200b-3p PRKCB 0.0717138787925347 0.682858087587209 -0.00995382054367333 0.966062170170983 MirTarget -0.25314056822959 1.19976246306159e-05 NA NA NA hsa-miR-200c-3p PRKCB 0.630251054099546 0.000131975031451555 -0.00995382054367333 0.966062170170983 MirTarget;miRNATAP -0.247883706249509 5.19535947946646e-05 NA NA NA hsa-miR-205-3p PRKCB 1.2960640797621 5.80786479909147e-11 -0.00995382054367333 0.966062170170983 mirMAP -0.139761356797048 0.00563704149985681 NA NA NA hsa-miR-23a-3p PRKCB 0.348231698801568 6.4911858506572e-05 -0.00995382054367333 0.966062170170983 mirMAP -0.585222638829513 5.31039580277569e-07 NA NA NA hsa-miR-24-3p PRKCB 0.13115428390042 0.203891651275156 -0.00995382054367333 0.966062170170983 miRNATAP -0.412248047896016 3.20409690969774e-05 NA NA NA hsa-miR-27a-3p PRKCB 0.348456440505425 0.00126682892514312 -0.00995382054367333 0.966062170170983 MirTarget;miRNATAP -0.586533342240413 3.06369418405208e-10 NA NA NA hsa-miR-335-3p PRKCB 0.336785882180547 0.0542446207938138 -0.00995382054367333 0.966062170170983 mirMAP -0.150801933292581 0.00964223317290781 NA NA NA hsa-miR-338-3p PRKCB -0.948755228846395 8.99167125682392e-08 -0.00995382054367333 0.966062170170983 miRanda -0.189063660103368 0.000843153123017634 NA NA NA hsa-miR-361-5p PRKCB 0.0803683277369505 0.314043140368058 -0.00995382054367333 0.966062170170983 MirTarget;miRanda;miRNATAP -0.375874177784515 0.00379764519521529 NA NA NA hsa-miR-429 PRKCB 0.559451508722375 0.00563641638673083 -0.00995382054367333 0.966062170170983 MirTarget;miRanda;miRNATAP -0.30122694602295 1.22808222979422e-09 NA NA NA hsa-miR-450b-5p PRKCB 1.25529820885833 1.18847120528666e-15 -0.00995382054367333 0.966062170170983 miRNATAP -0.164181125995606 0.00942767159258168 NA NA NA hsa-miR-452-3p PRKCB 1.09618110917892 2.21867884261816e-07 -0.00995382054367333 0.966062170170983 mirMAP -0.288633705564416 7.41556259016727e-10 NA NA NA hsa-miR-589-3p PRKCB 1.59559692667315 6.2886410639161e-15 -0.00995382054367333 0.966062170170983 mirMAP -0.224077186704912 7.93186780188175e-06 NA NA NA hsa-miR-590-5p PRKCB 0.763025362395968 3.65305892505623e-09 -0.00995382054367333 0.966062170170983 miRanda -0.36636674657937 2.16525521339557e-06 NA NA NA hsa-miR-944 PRKCB 1.47323925060177 2.61626403984929e-13 -0.00995382054367333 0.966062170170983 mirMAP -0.228083074030307 3.27391957426865e-06 NA NA NA hsa-miR-181a-5p PRKX 0.819060835827404 1.38616688310277e-13 -0.151603564440898 0.3779654538133 mirMAP -0.207430719919465 0.00177099251431452 NA NA NA hsa-miR-181b-5p PRKX 0.974255518824355 2.64876280203475e-16 -0.151603564440898 0.3779654538133 mirMAP -0.395265525562346 5.7519252637977e-11 NA NA NA hsa-miR-450b-5p PRKX 1.25529820885833 1.18847120528666e-15 -0.151603564440898 0.3779654538133 mirMAP -0.192275284682013 3.2143180494236e-05 NA NA NA hsa-miR-539-5p PRKX -0.15206998860136 0.492550733728996 -0.151603564440898 0.3779654538133 mirMAP -0.105402290296118 0.00200608976227561 NA NA NA hsa-miR-542-3p PRKX 0.643308814904977 8.81635403230104e-07 -0.151603564440898 0.3779654538133 mirMAP -0.325292565431366 6.95556775285496e-09 NA NA NA hsa-let-7g-3p PTPN5 0.637019243992294 0.000204623048574065 -1.64265933079567 1.10954598030759e-07 MirTarget -0.390203840728395 6.97709659022844e-07 NA NA NA hsa-miR-330-5p PTPN5 0.944693925383906 5.04972895657346e-13 -1.64265933079567 1.10954598030759e-07 miRanda -0.27722570865307 0.00681286692072277 NA NA NA hsa-miR-429 PTPN5 0.559451508722375 0.00563641638673083 -1.64265933079567 1.10954598030759e-07 miRanda -0.378391014188339 1.35132706111489e-08 NA NA NA hsa-miR-744-3p PTPN5 1.18973028739247 4.23716909078104e-10 -1.64265933079567 1.10954598030759e-07 MirTarget -0.480353860264207 3.71100547822375e-12 NA NA NA hsa-miR-940 PTPN5 1.25303020594374 1.3005368359451e-10 -1.64265933079567 1.10954598030759e-07 miRNATAP -0.312548411143983 6.35426056268384e-06 NA NA NA hsa-miR-379-5p PTPN7 -1.69128331601611 1.09803562910663e-17 0.848591930243916 0.000195490615868186 MirTarget -0.134446687136374 0.00596574320638537 NA NA NA hsa-miR-30d-3p PTPRR -0.577371911152798 2.02950840095287e-06 1.80303336282402 7.66302260143961e-10 MirTarget -0.376041944462753 0.00041120690942253 NA NA NA hsa-miR-30e-3p PTPRR -0.890635378639789 1.65740480611339e-16 1.80303336282402 7.66302260143961e-10 MirTarget -0.478129160310777 4.3668758572769e-05 NA NA NA hsa-miR-382-5p RAC1 -0.512675955239656 0.00311534081639733 0.060247613846359 0.436073210860324 MirTarget -0.110732405915093 6.53593148835981e-09 NA NA NA hsa-miR-375 RAC2 -4.24070205340868 7.48368361454041e-28 1.54722243723033 1.85515860629167e-17 miRanda -0.164694891845942 1.8370066353598e-17 NA NA NA hsa-miR-25-3p RAP1A 0.76549796417801 3.32282098247097e-11 -0.246786487812577 0.00126184977153121 mirMAP -0.183713766506326 5.5049525501694e-11 NA NA NA hsa-miR-324-5p RAP1A 1.66709479707179 1.45961450445769e-23 -0.246786487812577 0.00126184977153121 miRanda -0.100330547621404 1.19285734322161e-07 NA NA NA hsa-miR-335-3p RAP1A 0.336785882180547 0.0542446207938138 -0.246786487812577 0.00126184977153121 mirMAP -0.123830246444417 3.87374739353737e-11 NA NA NA hsa-miR-429 RAP1A 0.559451508722375 0.00563641638673083 -0.246786487812577 0.00126184977153121 miRanda -0.121275862458848 4.51324416694827e-14 NA NA NA hsa-miR-92a-3p RAP1A 0.994679542307232 1.32587679156217e-16 -0.246786487812577 0.00126184977153121 mirMAP;miRNATAP -0.184364247436964 3.46413061182987e-12 NA NA NA hsa-miR-101-3p RAP1B -1.91263766544878 1.50270129259053e-39 0.503686034143569 2.70398789015701e-09 MirTarget;miRNATAP -0.139095100476439 3.23137602956601e-09 24697700 Functional analysis of miR 101 3p and Rap1b involved in hepatitis B virus related hepatocellular carcinoma pathogenesis; In this study we reported that HBV could repress miR-101-3p by inhibiting its promoter activity and identified the potential effects of miR-101-3p on some important biological properties of HCC cells by targeting Rap1b; Down-regulation of miR-101-3p promoted cell proliferation migration and reduced apoptosis and resulted in up-regulation of Rap1b while overexpression of miR-101-3p inhibited these processes; Moreover overexpression of Rap1b was able to reverse the suppressed cell proliferation and migration mediated by miR-101-3p; Our data showed that HBV down-regulated miR-101-3p expression by inhibiting its promoter activity which resulted in up-regulation of Rap1b and down-regulation of miR-101-3p or up-regulation of Rap1b promoted proliferation and migration of HCC cells liver cancer hsa-miR-140-3p RAP1B -0.967453553824782 7.6999446305445e-23 0.503686034143569 2.70398789015701e-09 PITA;miRNATAP -0.149854193543746 4.08347955554151e-05 NA NA NA hsa-miR-27b-3p RAP1B -0.732682718863563 2.26896143573324e-09 0.503686034143569 2.70398789015701e-09 MirTarget -0.147747475130037 7.87251935836159e-07 NA NA NA hsa-miR-30d-5p RAP1B -0.38399848121878 0.000171129616944749 0.503686034143569 2.70398789015701e-09 MirTarget;miRNATAP -0.201454395241042 2.83702676239514e-08 NA NA NA hsa-miR-106b-5p RAPGEF2 0.50378717276868 1.45412404526866e-05 -0.531053999778023 7.95130860684206e-07 MirTarget;miRNATAP -0.211108694697283 1.56418021290848e-07 NA NA NA hsa-miR-10b-5p RAPGEF2 -0.582989331935508 4.56688330655626e-06 -0.531053999778023 7.95130860684206e-07 miRNATAP -0.133156478942892 0.000311591222692315 NA NA NA hsa-miR-141-3p RAPGEF2 0.730011517758706 0.000120338355004032 -0.531053999778023 7.95130860684206e-07 MirTarget;TargetScan;miRNATAP -0.215587293839163 2.0499479558784e-19 NA NA NA hsa-miR-149-5p RAPGEF2 0.443278770827687 0.0642022866136881 -0.531053999778023 7.95130860684206e-07 miRNAWalker2_validate -0.130798454962391 1.42529932803959e-11 NA NA NA hsa-miR-15a-5p RAPGEF2 0.783550182002274 2.60699595655907e-11 -0.531053999778023 7.95130860684206e-07 miRNATAP -0.359422222964358 4.90766312248149e-21 NA NA NA hsa-miR-15b-5p RAPGEF2 0.85315666454713 3.79816274836297e-12 -0.531053999778023 7.95130860684206e-07 miRNATAP -0.222205881719669 2.72764540180524e-09 NA NA NA hsa-miR-16-5p RAPGEF2 0.521122945828175 1.40561786410572e-06 -0.531053999778023 7.95130860684206e-07 miRNATAP -0.18569124034318 1.93145378536606e-05 NA NA NA hsa-miR-17-5p RAPGEF2 1.41924888736771 2.75805544953758e-18 -0.531053999778023 7.95130860684206e-07 MirTarget;TargetScan;miRNATAP -0.29711424200428 5.95665360676465e-29 NA NA NA hsa-miR-19a-3p RAPGEF2 1.35800152353624 2.80940447111944e-12 -0.531053999778023 7.95130860684206e-07 MirTarget;miRNATAP -0.241230523004339 1.74699099158835e-26 NA NA NA hsa-miR-19b-3p RAPGEF2 0.538732279378089 0.000622008277870679 -0.531053999778023 7.95130860684206e-07 MirTarget;miRNATAP -0.302890717692447 2.36359251288677e-26 NA NA NA hsa-miR-200a-3p RAPGEF2 0.607140814457753 0.00289840524858752 -0.531053999778023 7.95130860684206e-07 MirTarget;miRNATAP -0.174929647920008 8.77610216546556e-15 NA NA NA hsa-miR-200b-3p RAPGEF2 0.0717138787925347 0.682858087587209 -0.531053999778023 7.95130860684206e-07 MirTarget;TargetScan -0.162572233510696 1.01064121161305e-09 NA NA NA hsa-miR-200c-3p RAPGEF2 0.630251054099546 0.000131975031451555 -0.531053999778023 7.95130860684206e-07 MirTarget;miRNATAP -0.176231439984835 3.74839001549203e-10 NA NA NA hsa-miR-20a-5p RAPGEF2 1.1531986665452 1.02385132917958e-11 -0.531053999778023 7.95130860684206e-07 MirTarget;miRNATAP -0.291299833999354 2.06231373390968e-29 NA NA NA hsa-miR-30b-5p RAPGEF2 -0.400238605368173 0.00346540992719245 -0.531053999778023 7.95130860684206e-07 MirTarget;miRNATAP -0.206322504643451 1.42518371093772e-09 NA NA NA hsa-miR-30c-5p RAPGEF2 0.021222006155897 0.886366656528128 -0.531053999778023 7.95130860684206e-07 MirTarget;miRNATAP -0.225903967606511 5.258845944425e-13 NA NA NA hsa-miR-335-3p RAPGEF2 0.336785882180547 0.0542446207938138 -0.531053999778023 7.95130860684206e-07 mirMAP -0.142150343166596 1.1006816573711e-07 NA NA NA hsa-miR-339-5p RAPGEF2 1.07771430326938 2.45772601859307e-09 -0.531053999778023 7.95130860684206e-07 MirTarget;PITA -0.233273326894655 5.45604687279547e-21 NA NA NA hsa-miR-374b-3p RAPGEF2 0.425603499218802 0.00146686864653282 -0.531053999778023 7.95130860684206e-07 MirTarget -0.143982866180843 4.64640027590627e-05 NA NA NA hsa-miR-374b-5p RAPGEF2 -0.288413933608091 0.0041474558664058 -0.531053999778023 7.95130860684206e-07 mirMAP -0.159127487599539 0.000755601767284 NA NA NA hsa-miR-429 RAPGEF2 0.559451508722375 0.00563641638673083 -0.531053999778023 7.95130860684206e-07 MirTarget;PITA;miRanda;miRNATAP -0.185890023683731 2.5601644734327e-16 NA NA NA hsa-miR-93-5p RAPGEF2 1.61042951896619 5.1280369606967e-24 -0.531053999778023 7.95130860684206e-07 MirTarget;miRNATAP -0.289059781929789 8.64517012260326e-27 NA NA NA hsa-miR-944 RAPGEF2 1.47323925060177 2.61626403984929e-13 -0.531053999778023 7.95130860684206e-07 MirTarget;PITA;miRNATAP -0.11985581591407 1.27874840783956e-07 NA NA NA hsa-miR-130b-3p RASA1 1.44628430084411 9.13980959861273e-24 -0.201395100216696 0.0880260088457525 MirTarget -0.125536186034395 0.00023140558769781 NA NA NA hsa-miR-182-5p RASA1 1.15060905311096 6.25565852529946e-10 -0.201395100216696 0.0880260088457525 MirTarget;miRNATAP -0.121602832782192 6.69310313906577e-06 24600991;26126858 Hsa mir 182 downregulates RASA1 and suppresses lung squamous cell carcinoma cell proliferation; We further show that mir-182 downregulates RASA1;Hypoxia inducible MiR 182 promotes angiogenesis by targeting RASA1 in hepatocellular carcinoma; RASA1 was demonstrated as the direct target of miR-182; In addition the suppression of RASA1 phenocopied the pro-angiogenesis effects of miR-182; Besides RASA1 was also decreased in the hypoxia HCC cells while the inhibition of miR-182 partially restored the level of RASA1; Our data showed that hypoxia regulated the expression of miR-182 and RASA1 to promote HCC angiogenesis ; lung squamous cell cancer;liver cancer hsa-miR-188-5p RASA1 0.559328953885106 0.000430338888594543 -0.201395100216696 0.0880260088457525 PITA -0.12734758946746 7.92021059785717e-05 NA NA NA hsa-miR-30b-5p RASA1 -0.400238605368173 0.00346540992719245 -0.201395100216696 0.0880260088457525 MirTarget -0.161767358084959 1.49156983060018e-05 NA NA NA hsa-miR-30c-5p RASA1 0.021222006155897 0.886366656528128 -0.201395100216696 0.0880260088457525 miRNAWalker2_validate;MirTarget;miRNATAP -0.194627126292747 1.43638518143614e-08 NA NA NA hsa-miR-320a RASA1 0.801356001806321 4.91397101474502e-09 -0.201395100216696 0.0880260088457525 MirTarget;PITA;miRanda;miRNATAP -0.185402190742104 4.60744247627703e-07 NA NA NA hsa-miR-361-5p RASA1 0.0803683277369505 0.314043140368058 -0.201395100216696 0.0880260088457525 miRanda -0.324936134473172 5.76858431427009e-07 NA NA NA hsa-miR-454-3p RASA1 1.54137391927201 4.15861570449376e-20 -0.201395100216696 0.0880260088457525 MirTarget -0.111225624434347 0.000155207426429582 NA NA NA hsa-miR-590-5p RASA1 0.763025362395968 3.65305892505623e-09 -0.201395100216696 0.0880260088457525 miRNATAP -0.103932561967306 0.008192509920492 NA NA NA hsa-miR-92a-3p RASA1 0.994679542307232 1.32587679156217e-16 -0.201395100216696 0.0880260088457525 miRNAWalker2_validate -0.178193103969919 1.70046407925388e-05 NA NA NA hsa-miR-96-5p RASA1 1.42326703011157 4.39736150032373e-14 -0.201395100216696 0.0880260088457525 TargetScan;miRNATAP -0.106080528485832 6.11647241123611e-05 NA NA NA hsa-miR-141-3p RASA2 0.730011517758706 0.000120338355004032 -0.13563780086651 0.471912272909971 TargetScan -0.116888543535217 0.00656844547003129 NA NA NA hsa-miR-17-5p RASA2 1.41924888736771 2.75805544953758e-18 -0.13563780086651 0.471912272909971 TargetScan -0.210150313758388 1.49312971602003e-05 NA NA NA hsa-miR-30a-5p RASA2 -1.79779915425811 1.93360169837799e-26 -0.13563780086651 0.471912272909971 mirMAP -0.170238889323838 0.00021815984118059 NA NA NA hsa-miR-30b-5p RASA2 -0.400238605368173 0.00346540992719245 -0.13563780086651 0.471912272909971 mirMAP -0.388985822299261 4.24413370027813e-11 NA NA NA hsa-miR-30c-5p RASA2 0.021222006155897 0.886366656528128 -0.13563780086651 0.471912272909971 mirMAP -0.427788224342382 2.49362693272155e-15 NA NA NA hsa-miR-374b-5p RASA2 -0.288413933608091 0.0041474558664058 -0.13563780086651 0.471912272909971 mirMAP -0.446807835762717 3.83703894230157e-08 NA NA NA hsa-miR-589-3p RASA2 1.59559692667315 6.2886410639161e-15 -0.13563780086651 0.471912272909971 mirMAP -0.134764926187668 0.00090233285208231 NA NA NA hsa-miR-664a-3p RASA2 -0.256108763664991 0.0513188660751664 -0.13563780086651 0.471912272909971 mirMAP -0.321655055512382 2.23803121692591e-07 NA NA NA hsa-miR-708-3p RASA2 1.32647174389322 4.87465491977979e-16 -0.13563780086651 0.471912272909971 mirMAP -0.141050868128341 0.00384140323812247 NA NA NA hsa-let-7a-3p RASGRF2 0.0966652362351867 0.423761916840503 0.324230751966138 0.133235108703901 mirMAP -0.410714281286419 1.21583504683995e-07 NA NA NA hsa-miR-103a-2-5p RASGRF2 1.37988337975616 6.74852943995612e-08 0.324230751966138 0.133235108703901 mirMAP -0.251354621472508 1.1056716557037e-10 NA NA NA hsa-miR-106a-5p RASGRF2 0.67978010057847 0.00221925869726092 0.324230751966138 0.133235108703901 MirTarget -0.228326682382584 4.49367163166671e-08 NA NA NA hsa-miR-106b-5p RASGRF2 0.50378717276868 1.45412404526866e-05 0.324230751966138 0.133235108703901 MirTarget -0.248955631217454 0.00205988954364205 NA NA NA hsa-miR-17-5p RASGRF2 1.41924888736771 2.75805544953758e-18 0.324230751966138 0.133235108703901 MirTarget;TargetScan -0.488564331657432 1.49502419848785e-19 NA NA NA hsa-miR-182-5p RASGRF2 1.15060905311096 6.25565852529946e-10 0.324230751966138 0.133235108703901 mirMAP -0.290269368207463 3.4011332527012e-09 NA NA NA hsa-miR-20a-5p RASGRF2 1.1531986665452 1.02385132917958e-11 0.324230751966138 0.133235108703901 MirTarget -0.501625420583642 9.00291453560826e-22 NA NA NA hsa-miR-20b-5p RASGRF2 0.345967670847176 0.232014828043601 0.324230751966138 0.133235108703901 MirTarget -0.139679287700864 1.56104858414913e-05 NA NA NA hsa-miR-224-5p RASGRF2 1.94534596857416 1.88348779207332e-19 0.324230751966138 0.133235108703901 MirTarget -0.217967983106302 1.6432135265845e-07 NA NA NA hsa-miR-30d-3p RASGRF2 -0.577371911152798 2.02950840095287e-06 0.324230751966138 0.133235108703901 mirMAP -0.441016336173537 7.5554536808255e-09 NA NA NA hsa-miR-320a RASGRF2 0.801356001806321 4.91397101474502e-09 0.324230751966138 0.133235108703901 miRNATAP -0.248126839621469 0.000248526632757874 NA NA NA hsa-miR-324-5p RASGRF2 1.66709479707179 1.45961450445769e-23 0.324230751966138 0.133235108703901 miRNATAP -0.28739310284641 7.66501495935615e-08 NA NA NA hsa-miR-429 RASGRF2 0.559451508722375 0.00563641638673083 0.324230751966138 0.133235108703901 miRanda -0.424036108795227 2.26454474893344e-21 NA NA NA hsa-miR-590-3p RASGRF2 0.221436901462551 0.0965904764063157 0.324230751966138 0.133235108703901 MirTarget;miRanda -0.322579157378026 4.66177810769808e-06 NA NA NA hsa-miR-590-5p RASGRF2 0.763025362395968 3.65305892505623e-09 0.324230751966138 0.133235108703901 miRanda -0.535738748439942 2.43343780813432e-14 NA NA NA hsa-miR-708-3p RASGRF2 1.32647174389322 4.87465491977979e-16 0.324230751966138 0.133235108703901 mirMAP -0.148994120167179 0.00776809745987868 NA NA NA hsa-miR-93-5p RASGRF2 1.61042951896619 5.1280369606967e-24 0.324230751966138 0.133235108703901 MirTarget -0.339208435609099 1.10841154379648e-09 NA NA NA hsa-let-7d-5p RASGRP1 0.481757661442508 3.66030810124939e-07 -0.693551864053453 0.00413750396041983 MirTarget;miRNATAP -0.381971352308728 0.000604211187569194 NA NA NA hsa-let-7e-5p RASGRP1 0.0857356192778891 0.512869729833211 -0.693551864053453 0.00413750396041983 MirTarget;miRNATAP -0.408366090446792 3.81049997521249e-07 NA NA NA hsa-miR-154-3p RASGRP1 -0.459792546252935 0.0321099561293489 -0.693551864053453 0.00413750396041983 TargetScan -0.2333133973102 2.66945407225292e-06 NA NA NA hsa-miR-2355-3p RASGRP1 1.58434563546762 4.06578912176206e-18 -0.693551864053453 0.00413750396041983 MirTarget -0.348951401965968 2.44182759586472e-10 NA NA NA hsa-miR-320a RASGRP1 0.801356001806321 4.91397101474502e-09 -0.693551864053453 0.00413750396041983 miRanda -0.328292880725096 1.51877947346679e-05 NA NA NA hsa-miR-320b RASGRP1 1.23473838180754 3.04337566045537e-14 -0.693551864053453 0.00413750396041983 miRanda -0.21383389753746 0.00073703529913144 NA NA NA hsa-miR-655-3p RASGRP1 -1.15004187025356 3.60771552708797e-07 -0.693551864053453 0.00413750396041983 MirTarget -0.282601974940596 2.34188808175581e-09 NA NA NA hsa-miR-758-3p RASGRP1 -0.570329021195882 0.00789852529051916 -0.693551864053453 0.00413750396041983 MirTarget -0.2675253550604 3.78088187865205e-08 NA NA NA hsa-miR-324-3p RASGRP2 0.867391246413545 3.63808540490361e-10 -0.06026749303297 0.766162029378666 PITA -0.312705054301872 5.27233363939369e-07 NA NA NA hsa-miR-940 RASGRP2 1.25303020594374 1.3005368359451e-10 -0.06026749303297 0.766162029378666 MirTarget;PITA;miRNATAP -0.167672162742247 0.000185302602869422 NA NA NA hsa-miR-324-3p RASGRP3 0.867391246413545 3.63808540490361e-10 0.105424976730751 0.483961995570109 MirTarget -0.173913580069719 0.000187789114749438 NA NA NA hsa-miR-339-5p RASGRP3 1.07771430326938 2.45772601859307e-09 0.105424976730751 0.483961995570109 miRanda -0.209035783578357 3.076277048874e-09 NA NA NA hsa-miR-34c-5p RASGRP3 0.565896455062849 0.0224052732281715 0.105424976730751 0.483961995570109 miRanda -0.117969236700385 6.99079823554623e-06 NA NA NA hsa-miR-365a-3p RASGRP3 0.446833934952926 0.00233857759218299 0.105424976730751 0.483961995570109 MirTarget -0.212191413199659 1.66253545543494e-06 NA NA NA hsa-miR-589-3p RASGRP3 1.59559692667315 6.2886410639161e-15 0.105424976730751 0.483961995570109 mirMAP -0.156188734452918 1.25409996159763e-06 NA NA NA hsa-miR-590-5p RASGRP3 0.763025362395968 3.65305892505623e-09 0.105424976730751 0.483961995570109 miRanda -0.246689036945685 6.96632571495631e-07 NA NA NA hsa-miR-944 RASGRP3 1.47323925060177 2.61626403984929e-13 0.105424976730751 0.483961995570109 mirMAP -0.221284046759543 1.1436309702845e-12 NA NA NA hsa-miR-28-5p RELA -0.026996999089909 0.733047113251652 0.0427844130929831 0.511167069149631 miRanda -0.158597396386128 1.09687495536614e-05 NA NA NA hsa-miR-769-5p RELA 0.0865819375213306 0.445395188017017 0.0427844130929831 0.511167069149631 miRNATAP -0.115778992525935 3.19828405030521e-06 NA NA NA hsa-miR-125b-5p RPS6KA1 -0.993460109818276 5.07736727659894e-12 0.596749611096817 2.29662308108149e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.153562725015249 1.46644174198298e-06 NA NA NA hsa-miR-28-5p RPS6KA1 -0.026996999089909 0.733047113251652 0.596749611096817 2.29662308108149e-08 miRanda -0.220789370796156 0.0002605117684115 NA NA NA hsa-let-7g-3p RPS6KA2 0.637019243992294 0.000204623048574065 -0.818335052704694 1.49802394463738e-07 MirTarget -0.159282346530698 6.02012922742781e-05 NA NA NA hsa-miR-1271-5p RPS6KA2 0.564681884899804 0.000425257395055278 -0.818335052704694 1.49802394463738e-07 mirMAP -0.137646479459463 0.00127222769297982 NA NA NA hsa-miR-130b-5p RPS6KA2 1.77265255049999 1.43627774829684e-29 -0.818335052704694 1.49802394463738e-07 mirMAP -0.174974710379219 2.10165541609256e-05 NA NA NA hsa-miR-17-5p RPS6KA2 1.41924888736771 2.75805544953758e-18 -0.818335052704694 1.49802394463738e-07 TargetScan -0.377465112992773 6.31636695590034e-22 NA NA NA hsa-miR-193a-3p RPS6KA2 0.22120710726779 0.111827069464729 -0.818335052704694 1.49802394463738e-07 mirMAP -0.19256032016045 9.5536814573829e-05 NA NA NA hsa-miR-193b-3p RPS6KA2 1.72788400801602 3.0722151264559e-21 -0.818335052704694 1.49802394463738e-07 mirMAP -0.202082067184624 1.50481084371598e-08 NA NA NA hsa-miR-19a-3p RPS6KA2 1.35800152353624 2.80940447111944e-12 -0.818335052704694 1.49802394463738e-07 MirTarget -0.311634984678888 7.92960241402116e-21 NA NA NA hsa-miR-19b-3p RPS6KA2 0.538732279378089 0.000622008277870679 -0.818335052704694 1.49802394463738e-07 MirTarget -0.381223777198004 1.12744252755145e-19 NA NA NA hsa-miR-200b-3p RPS6KA2 0.0717138787925347 0.682858087587209 -0.818335052704694 1.49802394463738e-07 TargetScan -0.255615314712537 3.27827961462796e-11 NA NA NA hsa-miR-200c-3p RPS6KA2 0.630251054099546 0.000131975031451555 -0.818335052704694 1.49802394463738e-07 miRNATAP -0.247316725486219 1.49039287285506e-09 NA NA NA hsa-miR-21-3p RPS6KA2 1.25126438776674 2.4124216716282e-17 -0.818335052704694 1.49802394463738e-07 MirTarget -0.297454561784315 1.93095248173415e-11 NA NA NA hsa-miR-26b-5p RPS6KA2 -0.254478038884324 0.0285227763044636 -0.818335052704694 1.49802394463738e-07 miRNATAP -0.159613659119711 0.00723064319634244 NA NA NA hsa-miR-30b-5p RPS6KA2 -0.400238605368173 0.00346540992719245 -0.818335052704694 1.49802394463738e-07 MirTarget -0.203997361568164 4.47040554580069e-05 NA NA NA hsa-miR-30c-5p RPS6KA2 0.021222006155897 0.886366656528128 -0.818335052704694 1.49802394463738e-07 MirTarget;miRNATAP -0.177722948751106 0.000122221635439775 NA NA NA hsa-miR-429 RPS6KA2 0.559451508722375 0.00563641638673083 -0.818335052704694 1.49802394463738e-07 miRanda;miRNATAP -0.242130518638547 2.87557792828138e-13 NA NA NA hsa-miR-532-3p RPS6KA2 0.80240056676907 1.08989551712617e-09 -0.818335052704694 1.49802394463738e-07 MirTarget;mirMAP -0.184979835948607 0.000319663071786608 NA NA NA hsa-miR-9-5p RPS6KA2 1.65694862043766 2.08325802567323e-05 -0.818335052704694 1.49802394463738e-07 miRNATAP -0.106479212620095 6.19574002522226e-10 NA NA NA hsa-miR-93-3p RPS6KA2 1.69225547123293 1.50964095575087e-25 -0.818335052704694 1.49802394463738e-07 MirTarget -0.279898533867669 1.54537186298373e-12 NA NA NA hsa-miR-103a-3p RPS6KA3 0.556219385347418 1.55815736455067e-09 -0.288537450262601 0.0109275717451252 MirTarget -0.174681659311864 0.00105720081449375 NA NA NA hsa-miR-15a-5p RPS6KA3 0.783550182002274 2.60699595655907e-11 -0.288537450262601 0.0109275717451252 MirTarget;miRNATAP -0.254959516181223 4.37501425044547e-10 NA NA NA hsa-miR-17-5p RPS6KA3 1.41924888736771 2.75805544953758e-18 -0.288537450262601 0.0109275717451252 TargetScan;miRNATAP -0.128564368794749 1.08092048466133e-05 NA NA NA hsa-miR-181a-5p RPS6KA3 0.819060835827404 1.38616688310277e-13 -0.288537450262601 0.0109275717451252 MirTarget;mirMAP;miRNATAP -0.20832245711034 1.7111658647179e-06 NA NA NA hsa-miR-181b-5p RPS6KA3 0.974255518824355 2.64876280203475e-16 -0.288537450262601 0.0109275717451252 MirTarget;mirMAP;miRNATAP -0.233898069631251 5.03412183239972e-09 NA NA NA hsa-miR-20a-5p RPS6KA3 1.1531986665452 1.02385132917958e-11 -0.288537450262601 0.0109275717451252 miRNATAP -0.151380903515229 8.92443397551179e-08 NA NA NA hsa-miR-21-5p RPS6KA3 1.62465922021121 3.44191300985109e-58 -0.288537450262601 0.0109275717451252 miRNAWalker2_validate;mirMAP;miRNATAP -0.166170297916274 0.000143365312097424 NA NA NA hsa-miR-29b-1-5p RPS6KA3 1.39669186711325 4.36960953138935e-11 -0.288537450262601 0.0109275717451252 mirMAP -0.118049339934378 1.99502792388805e-07 NA NA NA hsa-miR-320a RPS6KA3 0.801356001806321 4.91397101474502e-09 -0.288537450262601 0.0109275717451252 miRNAWalker2_validate;miRanda -0.128263583257447 0.000311858781988534 NA NA NA hsa-miR-503-5p RPS6KA3 2.85210590411715 1.27298190263569e-35 -0.288537450262601 0.0109275717451252 miRNAWalker2_validate -0.10546766258564 4.55743405132703e-07 NA NA NA hsa-miR-93-5p RPS6KA3 1.61042951896619 5.1280369606967e-24 -0.288537450262601 0.0109275717451252 miRNATAP -0.122472749889238 3.33750446715353e-05 NA NA NA hsa-miR-25-3p RPS6KA4 0.76549796417801 3.32282098247097e-11 0.708117839302598 1.33731808490346e-08 MirTarget -0.255521321208506 3.99882301977081e-08 NA NA NA hsa-miR-296-5p RPS6KA4 -0.425442682383961 0.0948240114267711 0.708117839302598 1.33731808490346e-08 miRNATAP -0.111771409950219 3.37805286351024e-07 NA NA NA hsa-miR-32-5p RPS6KA4 -0.317310201890053 0.0102525324475293 0.708117839302598 1.33731808490346e-08 MirTarget -0.181672998131253 4.4100035956579e-05 NA NA NA hsa-miR-34a-5p RPS6KA4 -0.117372471043915 0.364001947180738 0.708117839302598 1.33731808490346e-08 MirTarget -0.268705060263851 1.77448674733482e-10 NA NA NA hsa-miR-363-3p RPS6KA4 -0.608157508016978 0.0186109501272176 0.708117839302598 1.33731808490346e-08 MirTarget -0.141995833791384 9.68372030629197e-12 NA NA NA hsa-miR-9-5p RPS6KA4 1.65694862043766 2.08325802567323e-05 0.708117839302598 1.33731808490346e-08 MirTarget -0.133048923881274 3.36452229675322e-23 NA NA NA hsa-miR-130a-3p RPS6KA5 0.67051191119964 4.89747518735144e-06 -0.635689995193579 3.47825449174147e-05 MirTarget -0.20490338544996 6.219871909676e-06 NA NA NA hsa-miR-17-5p RPS6KA5 1.41924888736771 2.75805544953758e-18 -0.635689995193579 3.47825449174147e-05 MirTarget;TargetScan -0.157986713178252 7.4652210649849e-05 NA NA NA hsa-miR-18a-5p RPS6KA5 1.65455873230328 3.76457892277775e-20 -0.635689995193579 3.47825449174147e-05 MirTarget -0.163083190304653 5.27117953475927e-06 NA NA NA hsa-miR-199a-5p RPS6KA5 -0.364835768178638 0.0435119211101981 -0.635689995193579 3.47825449174147e-05 miRanda -0.142362044175349 0.000126676245851765 NA NA NA hsa-miR-19a-3p RPS6KA5 1.35800152353624 2.80940447111944e-12 -0.635689995193579 3.47825449174147e-05 miRNAWalker2_validate;MirTarget -0.156900316515213 3.18863560032598e-06 NA NA NA hsa-miR-19b-3p RPS6KA5 0.538732279378089 0.000622008277870679 -0.635689995193579 3.47825449174147e-05 MirTarget -0.16956071267911 6.64018645529862e-05 NA NA NA hsa-miR-20a-3p RPS6KA5 1.34885093664027 2.07697464119202e-12 -0.635689995193579 3.47825449174147e-05 miRNATAP -0.12352434914867 0.000310390532205524 NA NA NA hsa-miR-20a-5p RPS6KA5 1.1531986665452 1.02385132917958e-11 -0.635689995193579 3.47825449174147e-05 MirTarget -0.141573841009627 0.000269486137752797 NA NA NA hsa-miR-301a-3p RPS6KA5 2.14132004241926 4.46255413526808e-25 -0.635689995193579 3.47825449174147e-05 MirTarget -0.155107728498804 4.41026172289883e-07 NA NA NA hsa-miR-342-3p RPS6KA5 0.99756868977753 9.28499866272332e-10 -0.635689995193579 3.47825449174147e-05 PITA;miRanda;miRNATAP -0.126986964915505 0.00179550902861117 NA NA NA hsa-miR-454-3p RPS6KA5 1.54137391927201 4.15861570449376e-20 -0.635689995193579 3.47825449174147e-05 MirTarget -0.201147738048787 1.50329057245853e-07 NA NA NA hsa-miR-664a-3p RPS6KA5 -0.256108763664991 0.0513188660751664 -0.635689995193579 3.47825449174147e-05 MirTarget;mirMAP -0.172252812382559 0.000794939317058077 NA NA NA hsa-miR-141-3p RPS6KA6 0.730011517758706 0.000120338355004032 -3.76847777386574 1.8223601760702e-19 MirTarget -0.366917777856374 0.000201799656432614 NA NA NA hsa-miR-15a-5p RPS6KA6 0.783550182002274 2.60699595655907e-11 -3.76847777386574 1.8223601760702e-19 MirTarget -1.12998133359345 3.32923849152607e-13 NA NA NA hsa-miR-15b-5p RPS6KA6 0.85315666454713 3.79816274836297e-12 -3.76847777386574 1.8223601760702e-19 MirTarget -0.628797262164557 2.9811400082452e-05 NA NA NA hsa-miR-16-5p RPS6KA6 0.521122945828175 1.40561786410572e-06 -3.76847777386574 1.8223601760702e-19 MirTarget -0.787839286203253 5.60843523438959e-06 NA NA NA hsa-miR-17-5p RPS6KA6 1.41924888736771 2.75805544953758e-18 -3.76847777386574 1.8223601760702e-19 TargetScan -0.686391408668744 5.66752618788398e-10 NA NA NA hsa-miR-19a-3p RPS6KA6 1.35800152353624 2.80940447111944e-12 -3.76847777386574 1.8223601760702e-19 MirTarget -0.668456836925976 7.33540361911542e-13 NA NA NA hsa-miR-19b-3p RPS6KA6 0.538732279378089 0.000622008277870679 -3.76847777386574 1.8223601760702e-19 MirTarget -0.556388192740529 2.90023177095393e-06 NA NA NA hsa-miR-205-3p RPS6KA6 1.2960640797621 5.80786479909147e-11 -3.76847777386574 1.8223601760702e-19 MirTarget -0.67542706887551 1.69917794966981e-13 NA NA NA hsa-miR-20a-3p RPS6KA6 1.34885093664027 2.07697464119202e-12 -3.76847777386574 1.8223601760702e-19 MirTarget -0.360252686697966 0.000176652501760457 NA NA NA hsa-miR-424-5p RPS6KA6 1.48125289532143 9.10372985713165e-19 -3.76847777386574 1.8223601760702e-19 MirTarget -0.670278572605216 4.41141758978883e-10 NA NA NA hsa-miR-589-3p RPS6KA6 1.59559692667315 6.2886410639161e-15 -3.76847777386574 1.8223601760702e-19 MirTarget -0.44654609483773 1.55318743944128e-06 NA NA NA hsa-miR-590-3p RPS6KA6 0.221436901462551 0.0965904764063157 -3.76847777386574 1.8223601760702e-19 MirTarget;miRanda;mirMAP;miRNATAP -0.540657690659165 0.000139044850681365 NA NA NA hsa-miR-140-3p RRAS2 -0.967453553824782 7.6999446305445e-23 0.702932455850408 1.99932755914681e-08 MirTarget;PITA;miRNATAP -0.382023795806488 6.68154764495553e-13 NA NA NA hsa-miR-194-5p RRAS2 -0.0214221838459805 0.872940154118701 0.702932455850408 1.99932755914681e-08 MirTarget -0.188563549594164 4.77239889595257e-06 NA NA NA hsa-miR-23b-3p RRAS2 -0.497563803223134 3.31483353357535e-05 0.702932455850408 1.99932755914681e-08 MirTarget -0.320399440089145 1.24982516371635e-12 NA NA NA hsa-miR-26a-5p RRAS2 -1.09269574587169 1.24020612216319e-22 0.702932455850408 1.99932755914681e-08 MirTarget -0.355116291989998 2.49215931328835e-14 NA NA NA hsa-miR-29a-3p RRAS2 -1.26881270980079 2.82496991513463e-22 0.702932455850408 1.99932755914681e-08 miRNATAP -0.142232445447152 0.000456450629215303 NA NA NA hsa-miR-29c-3p RRAS2 -2.08166260448948 8.3238369390898e-24 0.702932455850408 1.99932755914681e-08 miRNATAP -0.226677031708636 2.97636306035379e-20 NA NA NA hsa-miR-30a-5p RRAS2 -1.79779915425811 1.93360169837799e-26 0.702932455850408 1.99932755914681e-08 miRNATAP -0.120338084173712 0.000103191367577221 NA NA NA hsa-miR-30d-5p RRAS2 -0.38399848121878 0.000171129616944749 0.702932455850408 1.99932755914681e-08 miRNATAP -0.268206087702559 6.34913882454062e-07 NA NA NA hsa-miR-103a-2-5p SOS1 1.37988337975616 6.74852943995612e-08 -0.14430779210223 0.0788675470799712 MirTarget -0.107317494895258 2.70560419461077e-13 NA NA NA hsa-miR-17-5p SOS1 1.41924888736771 2.75805544953758e-18 -0.14430779210223 0.0788675470799712 MirTarget;TargetScan;miRNATAP -0.117731171602632 1.95189099419506e-08 NA NA NA hsa-miR-181a-5p SOS1 0.819060835827404 1.38616688310277e-13 -0.14430779210223 0.0788675470799712 MirTarget;miRNATAP -0.100672350932981 0.00144883651704136 NA NA NA hsa-miR-181b-5p SOS1 0.974255518824355 2.64876280203475e-16 -0.14430779210223 0.0788675470799712 MirTarget;miRNATAP -0.148558703111288 2.95988138178714e-07 NA NA NA hsa-miR-186-5p SOS1 0.353452958261612 0.000145058448579496 -0.14430779210223 0.0788675470799712 MirTarget;mirMAP -0.152552364062524 7.16812353278593e-05 NA NA NA hsa-miR-20a-5p SOS1 1.1531986665452 1.02385132917958e-11 -0.14430779210223 0.0788675470799712 MirTarget;miRNATAP -0.12022910939126 3.57951889599424e-09 NA NA NA hsa-miR-22-5p SOS1 0.706731861922839 3.44318705980007e-07 -0.14430779210223 0.0788675470799712 miRNATAP -0.158730685582191 2.71506892378126e-10 NA NA NA hsa-miR-30b-5p SOS1 -0.400238605368173 0.00346540992719245 -0.14430779210223 0.0788675470799712 mirMAP -0.126352161603185 1.03698542764349e-06 NA NA NA hsa-miR-30c-5p SOS1 0.021222006155897 0.886366656528128 -0.14430779210223 0.0788675470799712 mirMAP;miRNATAP -0.135903886215057 1.16781024741833e-08 NA NA NA hsa-miR-339-5p SOS1 1.07771430326938 2.45772601859307e-09 -0.14430779210223 0.0788675470799712 miRNATAP -0.128892301297403 1.48838832376727e-11 NA NA NA hsa-miR-365a-3p SOS1 0.446833934952926 0.00233857759218299 -0.14430779210223 0.0788675470799712 miRNATAP -0.1783566963117 5.57885493367077e-14 NA NA NA hsa-miR-576-5p SOS1 0.940432050128373 6.90227595663302e-12 -0.14430779210223 0.0788675470799712 mirMAP -0.137121069751198 5.95871216796928e-08 NA NA NA hsa-miR-590-5p SOS1 0.763025362395968 3.65305892505623e-09 -0.14430779210223 0.0788675470799712 miRanda -0.102087263279598 0.000173697009124336 NA NA NA hsa-miR-130a-3p SOS2 0.67051191119964 4.89747518735144e-06 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.142452400506012 9.1977279101434e-07 NA NA NA hsa-miR-130b-3p SOS2 1.44628430084411 9.13980959861273e-24 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.166141799618233 4.74896683998837e-09 NA NA NA hsa-miR-140-5p SOS2 -0.412389003031485 0.000136051708543369 -0.413855174319239 2.70724213132607e-05 miRanda -0.115984900471818 0.00375469960502604 NA NA NA hsa-miR-146b-5p SOS2 0.917975986853978 3.33749259316025e-09 -0.413855174319239 2.70724213132607e-05 miRanda -0.148988622111336 4.132997452968e-08 NA NA NA hsa-miR-15a-5p SOS2 0.783550182002274 2.60699595655907e-11 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.246192745452679 4.355188886614e-12 NA NA NA hsa-miR-15b-5p SOS2 0.85315666454713 3.79816274836297e-12 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.183474265512814 8.3295370014568e-08 NA NA NA hsa-miR-16-5p SOS2 0.521122945828175 1.40561786410572e-06 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.154096465704255 0.000106046501996405 NA NA NA hsa-miR-21-5p SOS2 1.62465922021121 3.44191300985109e-58 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.19831212276022 1.74180372845288e-07 NA NA NA hsa-miR-301a-3p SOS2 2.14132004241926 4.46255413526808e-25 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.120432560927103 7.67307961625067e-10 NA NA NA hsa-miR-320a SOS2 0.801356001806321 4.91397101474502e-09 -0.413855174319239 2.70724213132607e-05 miRanda;miRNATAP -0.180058190704833 4.89057631979479e-09 NA NA NA hsa-miR-454-3p SOS2 1.54137391927201 4.15861570449376e-20 -0.413855174319239 2.70724213132607e-05 miRNATAP -0.189860305441434 3.92270128753751e-15 NA NA NA hsa-miR-590-3p SOS2 0.221436901462551 0.0965904764063157 -0.413855174319239 2.70724213132607e-05 miRanda;mirMAP -0.11728383435213 0.000301105591653965 NA NA NA hsa-miR-590-5p SOS2 0.763025362395968 3.65305892505623e-09 -0.413855174319239 2.70724213132607e-05 PITA;miRanda;miRNATAP -0.141487335002342 1.65802166639907e-05 NA NA NA hsa-miR-148b-3p SRF 0.386859166050437 4.6728211830726e-06 -0.244911154069497 0.00101940603096044 mirMAP -0.160969488564295 2.87738769011849e-05 NA NA NA hsa-miR-140-5p STK3 -0.412389003031485 0.000136051708543369 0.798407094188578 1.68871676946511e-21 PITA;miRanda -0.176514898218827 4.23113809950716e-07 NA NA NA hsa-miR-29b-2-5p STK3 -0.502720326849742 0.000730448246894952 0.798407094188578 1.68871676946511e-21 MirTarget -0.129610585580681 2.82448960909338e-07 NA NA NA hsa-miR-199a-5p STK4 -0.364835768178638 0.0435119211101981 0.441383320872455 5.94781219218678e-07 MirTarget;PITA;miRanda;miRNATAP -0.134283532499914 2.16534408842331e-10 NA NA NA hsa-miR-199b-5p STK4 -1.08432682485992 7.68241801134089e-10 0.441383320872455 5.94781219218678e-07 MirTarget;PITA;miRanda;miRNATAP -0.148320825198252 3.01853905391201e-12 NA NA NA hsa-miR-30b-5p STK4 -0.400238605368173 0.00346540992719245 0.441383320872455 5.94781219218678e-07 mirMAP -0.147015913339128 1.69495044513221e-07 NA NA NA hsa-miR-30c-5p STK4 0.021222006155897 0.886366656528128 0.441383320872455 5.94781219218678e-07 mirMAP -0.107938471931551 3.59973259421155e-05 NA NA NA hsa-miR-30d-3p STK4 -0.577371911152798 2.02950840095287e-06 0.441383320872455 5.94781219218678e-07 mirMAP -0.133485121293029 2.58011987837031e-05 NA NA NA hsa-miR-362-5p STK4 0.41089772861323 0.0404254902071382 0.441383320872455 5.94781219218678e-07 mirMAP -0.127568048731838 1.91938636613902e-11 NA NA NA hsa-miR-374b-5p STK4 -0.288413933608091 0.0041474558664058 0.441383320872455 5.94781219218678e-07 mirMAP -0.128830141142017 0.000896012868443367 NA NA NA hsa-miR-495-3p STK4 -1.47803501311999 6.88839745293927e-13 0.441383320872455 5.94781219218678e-07 MirTarget -0.101290154759527 3.01186949363466e-08 NA NA NA hsa-miR-664a-3p STK4 -0.256108763664991 0.0513188660751664 0.441383320872455 5.94781219218678e-07 mirMAP -0.141373810864845 1.55872148833693e-06 NA NA NA hsa-miR-139-5p STMN1 -1.46099200329485 7.85040381494472e-22 1.15118142437777 4.59499355271216e-18 miRanda -0.198865838014644 1.0866635525161e-07 NA NA NA hsa-let-7a-3p TAOK1 0.0966652362351867 0.423761916840503 -0.381285817103181 0.0772091138704751 MirTarget;miRNATAP -0.473921852848627 8.47047813899159e-10 NA NA NA hsa-let-7d-5p TAOK1 0.481757661442508 3.66030810124939e-07 -0.381285817103181 0.0772091138704751 miRNATAP -0.28698095738275 0.00383773125341417 NA NA NA hsa-miR-106a-5p TAOK1 0.67978010057847 0.00221925869726092 -0.381285817103181 0.0772091138704751 miRNATAP -0.179944477411033 1.7927537137734e-05 NA NA NA hsa-miR-130a-3p TAOK1 0.67051191119964 4.89747518735144e-06 -0.381285817103181 0.0772091138704751 mirMAP -0.537196985448034 3.10502683001022e-18 NA NA NA hsa-miR-130b-5p TAOK1 1.77265255049999 1.43627774829684e-29 -0.381285817103181 0.0772091138704751 mirMAP -0.236224037900875 2.76970134817521e-05 NA NA NA hsa-miR-140-5p TAOK1 -0.412389003031485 0.000136051708543369 -0.381285817103181 0.0772091138704751 miRanda -0.250164258365817 0.00411004796058083 NA NA NA hsa-miR-142-3p TAOK1 1.12754191614028 1.68798138028946e-08 -0.381285817103181 0.0772091138704751 miRNAWalker2_validate;MirTarget;PITA;miRanda;miRNATAP -0.170504152513669 0.00022951146371673 NA NA NA hsa-miR-154-5p TAOK1 -1.13666358116162 1.83050913061273e-08 -0.381285817103181 0.0772091138704751 miRNATAP -0.123934742140997 0.0075131681052174 NA NA NA hsa-miR-15a-5p TAOK1 0.783550182002274 2.60699595655907e-11 -0.381285817103181 0.0772091138704751 MirTarget -0.829749864631307 1.2786937101928e-28 NA NA NA hsa-miR-16-5p TAOK1 0.521122945828175 1.40561786410572e-06 -0.381285817103181 0.0772091138704751 MirTarget;miRNATAP -0.300835883304482 0.00052155097053708 NA NA NA hsa-miR-17-5p TAOK1 1.41924888736771 2.75805544953758e-18 -0.381285817103181 0.0772091138704751 TargetScan;miRNATAP -0.419276400443191 1.55465683194296e-14 NA NA NA hsa-miR-181a-5p TAOK1 0.819060835827404 1.38616688310277e-13 -0.381285817103181 0.0772091138704751 mirMAP;miRNATAP -0.430115186199854 1.98262354058373e-07 NA NA NA hsa-miR-181b-5p TAOK1 0.974255518824355 2.64876280203475e-16 -0.381285817103181 0.0772091138704751 mirMAP;miRNATAP -0.384249518799927 5.040599682767e-07 NA NA NA hsa-miR-182-5p TAOK1 1.15060905311096 6.25565852529946e-10 -0.381285817103181 0.0772091138704751 miRNATAP -0.201862455846882 4.56913757465457e-05 NA NA NA hsa-miR-186-5p TAOK1 0.353452958261612 0.000145058448579496 -0.381285817103181 0.0772091138704751 mirMAP -0.641850152887234 1.44400116472041e-10 NA NA NA hsa-miR-18a-5p TAOK1 1.65455873230328 3.76457892277775e-20 -0.381285817103181 0.0772091138704751 MirTarget;miRNATAP -0.388880434635837 2.16112443405488e-15 NA NA NA hsa-miR-193a-3p TAOK1 0.22120710726779 0.111827069464729 -0.381285817103181 0.0772091138704751 MirTarget;miRNATAP -0.261964030232668 0.000106731356305072 NA NA NA hsa-miR-193b-3p TAOK1 1.72788400801602 3.0722151264559e-21 -0.381285817103181 0.0772091138704751 MirTarget;miRNATAP -0.170987342308111 0.000532664136012268 NA NA NA hsa-miR-194-3p TAOK1 0.735945243226384 8.65425299041628e-05 -0.381285817103181 0.0772091138704751 miRNATAP -0.157224484027107 0.00205235284980935 NA NA NA hsa-miR-197-3p TAOK1 0.878693269130833 3.84847526014135e-15 -0.381285817103181 0.0772091138704751 MirTarget;miRNATAP -0.301887540665482 0.000237635719635082 NA NA NA hsa-miR-199a-5p TAOK1 -0.364835768178638 0.0435119211101981 -0.381285817103181 0.0772091138704751 MirTarget;miRanda;miRNATAP -0.166992280630905 0.00131568697197349 NA NA NA hsa-miR-199b-5p TAOK1 -1.08432682485992 7.68241801134089e-10 -0.381285817103181 0.0772091138704751 MirTarget;miRanda;miRNATAP -0.217014268610589 3.31462861626878e-05 NA NA NA hsa-miR-19a-3p TAOK1 1.35800152353624 2.80940447111944e-12 -0.381285817103181 0.0772091138704751 MirTarget;miRNATAP -0.496839673928421 1.68921032503411e-28 NA NA NA hsa-miR-19b-3p TAOK1 0.538732279378089 0.000622008277870679 -0.381285817103181 0.0772091138704751 MirTarget;miRNATAP -0.648994254693632 7.40287870043548e-31 NA NA NA hsa-miR-205-5p TAOK1 1.50759485376634 2.0003886738248e-16 -0.381285817103181 0.0772091138704751 mirMAP;miRNATAP -0.23039960289124 3.16687725546308e-06 NA NA NA hsa-miR-20a-5p TAOK1 1.1531986665452 1.02385132917958e-11 -0.381285817103181 0.0772091138704751 miRNATAP -0.483427375527655 3.16140292672038e-20 NA NA NA hsa-miR-20b-5p TAOK1 0.345967670847176 0.232014828043601 -0.381285817103181 0.0772091138704751 miRNATAP -0.164465281775596 3.28225564536104e-07 NA NA NA hsa-miR-217 TAOK1 -1.35391381055929 2.42394951427902e-09 -0.381285817103181 0.0772091138704751 miRanda -0.135052932746899 0.000909517481331605 NA NA NA hsa-miR-222-3p TAOK1 1.08197052578759 2.32604040301699e-14 -0.381285817103181 0.0772091138704751 miRNATAP -0.22024027690125 0.000663368304767541 NA NA NA hsa-miR-26a-2-3p TAOK1 -0.444498687388748 0.00325793861409413 -0.381285817103181 0.0772091138704751 mirMAP -0.435373476268148 9.77404773502241e-13 NA NA NA hsa-miR-26b-3p TAOK1 0.421575313079363 0.00223298166810883 -0.381285817103181 0.0772091138704751 mirMAP -0.208995572794903 0.00217421744534586 NA NA NA hsa-miR-26b-5p TAOK1 -0.254478038884324 0.0285227763044636 -0.381285817103181 0.0772091138704751 mirMAP;miRNATAP -0.580914026045821 2.99531089888213e-13 NA NA NA hsa-miR-29a-5p TAOK1 0.323252792625584 0.0370417231222825 -0.381285817103181 0.0772091138704751 mirMAP -0.484448489243661 2.36696039092829e-16 NA NA NA hsa-miR-29b-2-5p TAOK1 -0.502720326849742 0.000730448246894952 -0.381285817103181 0.0772091138704751 MirTarget -0.362940861243135 5.73429018199127e-09 NA NA NA hsa-miR-301a-3p TAOK1 2.14132004241926 4.46255413526808e-25 -0.381285817103181 0.0772091138704751 mirMAP -0.314384356788222 1.05731968837587e-13 NA NA NA hsa-miR-30a-5p TAOK1 -1.79779915425811 1.93360169837799e-26 -0.381285817103181 0.0772091138704751 MirTarget;miRNATAP -0.194590756858791 0.000226597165407546 NA NA NA hsa-miR-30b-5p TAOK1 -0.400238605368173 0.00346540992719245 -0.381285817103181 0.0772091138704751 miRNAWalker2_validate;MirTarget -0.636085286090605 5.92294330657306e-22 NA NA NA hsa-miR-30c-5p TAOK1 0.021222006155897 0.886366656528128 -0.381285817103181 0.0772091138704751 MirTarget;miRNATAP -0.675477701922678 2.87425048149734e-29 NA NA NA hsa-miR-30d-3p TAOK1 -0.577371911152798 2.02950840095287e-06 -0.381285817103181 0.0772091138704751 miRNATAP -0.386422231397063 4.51638383979942e-07 NA NA NA hsa-miR-320a TAOK1 0.801356001806321 4.91397101474502e-09 -0.381285817103181 0.0772091138704751 mirMAP;miRNATAP -0.445834839790394 2.32183632718063e-11 NA NA NA hsa-miR-324-5p TAOK1 1.66709479707179 1.45961450445769e-23 -0.381285817103181 0.0772091138704751 miRanda -0.377355217859774 9.74540969802582e-13 NA NA NA hsa-miR-339-5p TAOK1 1.07771430326938 2.45772601859307e-09 -0.381285817103181 0.0772091138704751 miRanda -0.467798260412756 2.46915896083975e-21 NA NA NA hsa-miR-33a-5p TAOK1 1.12988965056352 3.35742517382153e-07 -0.381285817103181 0.0772091138704751 mirMAP -0.108465812223734 0.00980788766407643 NA NA NA hsa-miR-342-3p TAOK1 0.99756868977753 9.28499866272332e-10 -0.381285817103181 0.0772091138704751 miRanda -0.494581684844891 2.14896850177908e-19 NA NA NA hsa-miR-362-3p TAOK1 -0.697212068252854 2.61718493418184e-06 -0.381285817103181 0.0772091138704751 miRanda -0.305196079990908 1.15178797863358e-06 NA NA NA hsa-miR-374a-3p TAOK1 -0.299190081500425 0.00682975596757891 -0.381285817103181 0.0772091138704751 mirMAP -0.365365105978365 1.73391200798009e-05 NA NA NA hsa-miR-374b-3p TAOK1 0.425603499218802 0.00146686864653282 -0.381285817103181 0.0772091138704751 MirTarget -0.201926069684748 0.00423924590426568 NA NA NA hsa-miR-374b-5p TAOK1 -0.288413933608091 0.0041474558664058 -0.381285817103181 0.0772091138704751 mirMAP;miRNATAP -0.630815417200739 8.7142193520245e-12 NA NA NA hsa-miR-424-5p TAOK1 1.48125289532143 9.10372985713165e-19 -0.381285817103181 0.0772091138704751 MirTarget -0.162956521034931 0.00266075307039334 NA NA NA hsa-miR-425-5p TAOK1 0.931027421598738 6.46235724408844e-08 -0.381285817103181 0.0772091138704751 miRNAWalker2_validate -0.208071225693572 0.000109844757547552 NA NA NA hsa-miR-429 TAOK1 0.559451508722375 0.00563641638673083 -0.381285817103181 0.0772091138704751 MirTarget;mirMAP;miRNATAP -0.221671590738354 1.50882449039038e-06 NA NA NA hsa-miR-450b-5p TAOK1 1.25529820885833 1.18847120528666e-15 -0.381285817103181 0.0772091138704751 MirTarget;PITA;miRNATAP -0.155810593685107 0.00762800392038552 NA NA NA hsa-miR-454-3p TAOK1 1.54137391927201 4.15861570449376e-20 -0.381285817103181 0.0772091138704751 mirMAP -0.537825707873071 1.5057073401263e-25 NA NA NA hsa-miR-455-5p TAOK1 1.408595672323 5.52039116456697e-22 -0.381285817103181 0.0772091138704751 MirTarget;miRNATAP -0.359483104334809 3.91558829628039e-09 NA NA NA hsa-miR-495-3p TAOK1 -1.47803501311999 6.88839745293927e-13 -0.381285817103181 0.0772091138704751 mirMAP -0.128085977991305 0.00422482579379184 NA NA NA hsa-miR-497-5p TAOK1 -0.966244470847844 5.26505649147857e-12 -0.381285817103181 0.0772091138704751 MirTarget -0.189401412357693 0.00406915362031104 NA NA NA hsa-miR-501-3p TAOK1 0.820141346319976 1.74562930463389e-08 -0.381285817103181 0.0772091138704751 miRNATAP -0.435748869778145 3.8563075679743e-12 NA NA NA hsa-miR-501-5p TAOK1 1.02806906860218 1.63456814370548e-09 -0.381285817103181 0.0772091138704751 miRNATAP -0.347147556082261 1.55052213246398e-10 NA NA NA hsa-miR-505-3p TAOK1 0.912823669571645 4.0549774967148e-13 -0.381285817103181 0.0772091138704751 mirMAP -0.419831002620887 6.81540346294331e-09 NA NA NA hsa-miR-576-5p TAOK1 0.940432050128373 6.90227595663302e-12 -0.381285817103181 0.0772091138704751 mirMAP -0.509551651373422 9.30235673162443e-15 NA NA NA hsa-miR-582-3p TAOK1 -0.248056267546012 0.143798829508405 -0.381285817103181 0.0772091138704751 miRNATAP -0.256287761373242 3.35667758208538e-06 NA NA NA hsa-miR-582-5p TAOK1 -0.0366995972742474 0.821827119138923 -0.381285817103181 0.0772091138704751 MirTarget;miRNATAP -0.376395731241645 3.70413808239144e-11 NA NA NA hsa-miR-590-3p TAOK1 0.221436901462551 0.0965904764063157 -0.381285817103181 0.0772091138704751 miRanda;mirMAP -0.290090742198011 3.92395375287243e-05 NA NA NA hsa-miR-655-3p TAOK1 -1.15004187025356 3.60771552708797e-07 -0.381285817103181 0.0772091138704751 MirTarget -0.170714446495633 5.89601380431703e-05 NA NA NA hsa-miR-664a-3p TAOK1 -0.256108763664991 0.0513188660751664 -0.381285817103181 0.0772091138704751 mirMAP -0.498466894822167 1.43824690804958e-12 NA NA NA hsa-miR-7-1-3p TAOK1 1.13646121619622 1.49823237535933e-14 -0.381285817103181 0.0772091138704751 mirMAP -0.28380529620035 4.24692346052721e-06 NA NA NA hsa-miR-708-3p TAOK1 1.32647174389322 4.87465491977979e-16 -0.381285817103181 0.0772091138704751 MirTarget;miRNATAP -0.239954449134877 1.61443710109243e-05 NA NA NA hsa-miR-769-3p TAOK1 0.89886491506181 2.21711828717073e-08 -0.381285817103181 0.0772091138704751 MirTarget;miRNATAP -0.228735979591219 8.26592449104966e-05 NA NA NA hsa-miR-93-5p TAOK1 1.61042951896619 5.1280369606967e-24 -0.381285817103181 0.0772091138704751 miRNATAP -0.426906415019896 8.82950761261427e-15 NA NA NA hsa-miR-96-5p TAOK1 1.42326703011157 4.39736150032373e-14 -0.381285817103181 0.0772091138704751 miRNAWalker2_validate;TargetScan;miRNATAP -0.272363715343652 1.46945460340776e-08 NA NA NA hsa-miR-99b-5p TAOK1 0.44137573438014 9.0939587647735e-05 -0.381285817103181 0.0772091138704751 MirTarget;miRNATAP -0.231257798311068 0.00559526672338146 NA NA NA hsa-miR-106b-5p TAOK3 0.50378717276868 1.45412404526866e-05 -0.140036791221918 0.133381381443564 MirTarget -0.189336466091761 3.95829666442209e-08 NA NA NA hsa-miR-16-2-3p TAOK3 1.1567130855258 1.01867256952189e-14 -0.140036791221918 0.133381381443564 MirTarget -0.13135002908188 5.57161928028498e-07 NA NA NA hsa-miR-17-5p TAOK3 1.41924888736771 2.75805544953758e-18 -0.140036791221918 0.133381381443564 MirTarget;TargetScan -0.151635619632334 1.64788321753897e-10 NA NA NA hsa-miR-18a-5p TAOK3 1.65455873230328 3.76457892277775e-20 -0.140036791221918 0.133381381443564 miRNATAP -0.12140353538245 1.50172417318412e-08 NA NA NA hsa-miR-197-3p TAOK3 0.878693269130833 3.84847526014135e-15 -0.140036791221918 0.133381381443564 miRNATAP -0.129652496192926 0.000250685242042815 NA NA NA hsa-miR-19b-1-5p TAOK3 0.757034032029085 2.99828133413343e-07 -0.140036791221918 0.133381381443564 MirTarget -0.100802876872037 0.000202294880465901 NA NA NA hsa-miR-200b-3p TAOK3 0.0717138787925347 0.682858087587209 -0.140036791221918 0.133381381443564 MirTarget;TargetScan -0.117713527194747 2.88740613454905e-07 NA NA NA hsa-miR-20a-5p TAOK3 1.1531986665452 1.02385132917958e-11 -0.140036791221918 0.133381381443564 MirTarget -0.162064967446215 1.81476871226235e-12 NA NA NA hsa-miR-218-5p TAOK3 -1.0725338636959 3.61493686604269e-09 -0.140036791221918 0.133381381443564 miRNATAP -0.134176284463619 5.89134020971689e-10 NA NA NA hsa-miR-320a TAOK3 0.801356001806321 4.91397101474502e-09 -0.140036791221918 0.133381381443564 miRanda -0.168931019238385 5.02125430620997e-09 NA NA NA hsa-miR-335-3p TAOK3 0.336785882180547 0.0542446207938138 -0.140036791221918 0.133381381443564 MirTarget -0.150020024049343 4.65653000448915e-11 NA NA NA hsa-miR-361-5p TAOK3 0.0803683277369505 0.314043140368058 -0.140036791221918 0.133381381443564 miRanda -0.248299542219595 1.31581211101698e-06 NA NA NA hsa-miR-429 TAOK3 0.559451508722375 0.00563641638673083 -0.140036791221918 0.133381381443564 MirTarget;PITA;miRanda;miRNATAP -0.131185544438155 2.53976113599532e-11 NA NA NA hsa-miR-93-5p TAOK3 1.61042951896619 5.1280369606967e-24 -0.140036791221918 0.133381381443564 MirTarget -0.209119355038235 6.04046940775437e-19 NA NA NA hsa-miR-139-5p TGFB1 -1.46099200329485 7.85040381494472e-22 1.63261254184582 2.57292771878501e-37 miRanda -0.211396728970549 1.66114173348681e-08 NA NA NA hsa-miR-29b-3p TGFB1 -0.110721443686039 0.511264554091106 1.63261254184582 2.57292771878501e-37 miRTarBase -0.115557141630177 0.00118189427407973 NA NA NA hsa-miR-141-3p TGFB2 0.730011517758706 0.000120338355004032 0.0777328362726655 0.723018455166753 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.265467824704804 8.27771461885267e-08 NA NA NA hsa-miR-142-3p TGFB2 1.12754191614028 1.68798138028946e-08 0.0777328362726655 0.723018455166753 miRNATAP -0.16064296699396 0.000634225971259789 NA NA NA hsa-miR-149-5p TGFB2 0.443278770827687 0.0642022866136881 0.0777328362726655 0.723018455166753 MirTarget;miRNATAP -0.224915548613611 1.07874560543081e-08 NA NA NA hsa-miR-200a-3p TGFB2 0.607140814457753 0.00289840524858752 0.0777328362726655 0.723018455166753 MirTarget;miRNATAP -0.245845232906061 1.05145500844554e-07 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 0.0441399794719697 0.880456392176704 0.0777328362726655 0.723018455166753 MirTarget -0.213491686707761 2.34238525013733e-11 NA NA NA hsa-miR-29b-3p TGFB2 -0.110721443686039 0.511264554091106 0.0777328362726655 0.723018455166753 miRTarBase;MirTarget;miRNATAP -0.160451483561471 0.00470479835294533 NA NA NA hsa-miR-33a-3p TGFB2 0.20371038027126 0.212335697664505 0.0777328362726655 0.723018455166753 MirTarget;mirMAP -0.284781670411935 1.38897599512622e-06 NA NA NA hsa-miR-362-5p TGFB2 0.41089772861323 0.0404254902071382 0.0777328362726655 0.723018455166753 MirTarget -0.221176820672115 2.86666724884053e-06 NA NA NA hsa-miR-429 TGFB2 0.559451508722375 0.00563641638673083 0.0777328362726655 0.723018455166753 miRNATAP -0.213199102441814 5.30129859548984e-06 NA NA NA hsa-miR-454-3p TGFB2 1.54137391927201 4.15861570449376e-20 0.0777328362726655 0.723018455166753 MirTarget;miRNATAP -0.160741300174909 0.00334509150397591 NA NA NA hsa-miR-500a-5p TGFB2 0.675401699376111 8.24389004707854e-05 0.0777328362726655 0.723018455166753 mirMAP -0.159447320526312 0.00397529568273535 NA NA NA hsa-miR-500b-5p TGFB2 0.674875511637057 8.39602242688137e-05 0.0777328362726655 0.723018455166753 MirTarget -0.160233047874767 0.00378717200794635 NA NA NA hsa-miR-589-3p TGFB2 1.59559692667315 6.2886410639161e-15 0.0777328362726655 0.723018455166753 MirTarget -0.123357495887196 0.00914033095581057 NA NA NA hsa-miR-590-5p TGFB2 0.763025362395968 3.65305892505623e-09 0.0777328362726655 0.723018455166753 miRanda;miRNATAP -0.342026904103455 2.39104051032236e-06 NA NA NA hsa-miR-944 TGFB2 1.47323925060177 2.61626403984929e-13 0.0777328362726655 0.723018455166753 mirMAP -0.166241708180204 0.000315071117627543 NA NA NA hsa-let-7a-3p TGFB3 0.0966652362351867 0.423761916840503 1.00893266823856 2.40088713170131e-07 MirTarget -0.216799599468632 0.00248516203461445 NA NA NA hsa-miR-26b-3p TGFB3 0.421575313079363 0.00223298166810883 1.00893266823856 2.40088713170131e-07 MirTarget -0.227871116558054 0.000253998125314173 NA NA NA hsa-miR-29b-3p TGFB3 -0.110721443686039 0.511264554091106 1.00893266823856 2.40088713170131e-07 miRTarBase -0.233447034464102 4.45758973897005e-06 NA NA NA hsa-miR-590-3p TGFB3 0.221436901462551 0.0965904764063157 1.00893266823856 2.40088713170131e-07 miRanda -0.212001265861609 0.00106335445516084 NA NA NA hsa-miR-629-3p TGFB3 1.43262037314105 2.37092217984413e-19 1.00893266823856 2.40088713170131e-07 MirTarget -0.176865315949139 0.000694496344538885 NA NA NA hsa-miR-101-3p TGFBR1 -1.91263766544878 1.50270129259053e-39 0.615617809402788 1.98384557846381e-08 miRNAWalker2_validate;miRNATAP -0.137242751276775 7.52092687571314e-06 NA NA NA hsa-miR-101-5p TGFBR1 -1.429324744941 4.00032662184937e-18 0.615617809402788 1.98384557846381e-08 mirMAP -0.133177319619643 2.37858441571769e-06 NA NA NA hsa-miR-125b-5p TGFBR1 -0.993460109818276 5.07736727659894e-12 0.615617809402788 1.98384557846381e-08 miRNATAP -0.15777834540882 1.45852749097952e-06 NA NA NA hsa-miR-181c-5p TGFBR1 -0.168991199007857 0.196949106150297 0.615617809402788 1.98384557846381e-08 mirMAP;miRNATAP -0.10421464495814 0.0049760261835319 NA NA NA hsa-miR-200b-3p TGFBR1 0.0717138787925347 0.682858087587209 0.615617809402788 1.98384557846381e-08 mirMAP -0.197410832791802 2.77510960964195e-13 20498632 Inhibition of TGFbeta receptor 1 TGFBR1 in these cells induced MET and reduction of prometastatic miR-21 but caused an increase of the miR-200 family thyroid cancer hsa-miR-361-5p TGFBR1 0.0803683277369505 0.314043140368058 0.615617809402788 1.98384557846381e-08 miRanda;mirMAP;miRNATAP -0.161140636642561 0.00903876484470876 NA NA NA hsa-miR-374a-5p TGFBR1 -0.621903385111545 6.61791773205282e-12 0.615617809402788 1.98384557846381e-08 mirMAP -0.162078010547043 0.00217725764527797 NA NA NA hsa-miR-374b-5p TGFBR1 -0.288413933608091 0.0041474558664058 0.615617809402788 1.98384557846381e-08 mirMAP -0.207273863828956 1.67941177062955e-05 NA NA NA hsa-miR-429 TGFBR1 0.559451508722375 0.00563641638673083 0.615617809402788 1.98384557846381e-08 miRanda;miRNATAP -0.155570000352315 3.37635898013511e-11 NA NA NA hsa-miR-664a-3p TGFBR1 -0.256108763664991 0.0513188660751664 0.615617809402788 1.98384557846381e-08 mirMAP -0.200405898397308 4.18541096888924e-08 NA NA NA hsa-miR-106a-5p TGFBR2 0.67978010057847 0.00221925869726092 -0.433829718000188 0.0135145061644855 miRTarBase;miRNATAP -0.255393044945105 2.71545223274384e-14 22912877 MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion cell migration colorectal cancer hsa-miR-106b-5p TGFBR2 0.50378717276868 1.45412404526866e-05 -0.433829718000188 0.0135145061644855 miRNATAP -0.545456782286389 1.33851981046724e-17 NA NA NA hsa-miR-130a-3p TGFBR2 0.67051191119964 4.89747518735144e-06 -0.433829718000188 0.0135145061644855 miRNATAP -0.233720846507776 5.92987815592498e-06 NA NA NA hsa-miR-130b-3p TGFBR2 1.44628430084411 9.13980959861273e-24 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate;miRNATAP -0.390455313786453 4.03477020820313e-15 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 1.41924888736771 2.75805544953758e-18 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.420579241358807 7.61600448040271e-22 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-18a-5p TGFBR2 1.65455873230328 3.76457892277775e-20 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate -0.322639732975004 6.25654643349646e-16 NA NA NA hsa-miR-19a-3p TGFBR2 1.35800152353624 2.80940447111944e-12 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate;miRNATAP -0.341667968021617 4.33453479376719e-20 NA NA NA hsa-miR-19b-3p TGFBR2 0.538732279378089 0.000622008277870679 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate;miRNATAP -0.466136413197791 1.17242031237057e-23 NA NA NA hsa-miR-20a-5p TGFBR2 1.1531986665452 1.02385132917958e-11 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate;miRTarBase;miRNATAP -0.433886761312993 1.28958621534827e-24 NA NA NA hsa-miR-20b-5p TGFBR2 0.345967670847176 0.232014828043601 -0.433829718000188 0.0135145061644855 miRNATAP -0.203374864266804 3.23250679695954e-15 NA NA NA hsa-miR-23b-3p TGFBR2 -0.497563803223134 3.31483353357535e-05 -0.433829718000188 0.0135145061644855 miRNATAP -0.203411673528942 0.00142820710804535 NA NA NA hsa-miR-29b-2-5p TGFBR2 -0.502720326849742 0.000730448246894952 -0.433829718000188 0.0135145061644855 mirMAP -0.208499831431345 4.6618592916398e-05 NA NA NA hsa-miR-301a-3p TGFBR2 2.14132004241926 4.46255413526808e-25 -0.433829718000188 0.0135145061644855 miRNATAP -0.231775665365658 2.20860839363543e-11 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-320a TGFBR2 0.801356001806321 4.91397101474502e-09 -0.433829718000188 0.0135145061644855 miRanda;miRNATAP -0.347747831358455 1.70608718391257e-10 NA NA NA hsa-miR-320b TGFBR2 1.23473838180754 3.04337566045537e-14 -0.433829718000188 0.0135145061644855 miRanda;miRNATAP -0.303558439833062 1.8858687275721e-11 NA NA NA hsa-miR-335-3p TGFBR2 0.336785882180547 0.0542446207938138 -0.433829718000188 0.0135145061644855 mirMAP -0.291745913178869 1.21540724972883e-11 NA NA NA hsa-miR-335-5p TGFBR2 -1.17227779671552 1.49282618530733e-10 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate -0.121435164126501 0.00315771117150945 NA NA NA hsa-miR-33a-3p TGFBR2 0.20371038027126 0.212335697664505 -0.433829718000188 0.0135145061644855 mirMAP -0.268664607255719 1.22612921559662e-08 NA NA NA hsa-miR-429 TGFBR2 0.559451508722375 0.00563641638673083 -0.433829718000188 0.0135145061644855 miRNATAP -0.414910311589602 2.47671709912537e-31 NA NA NA hsa-miR-454-3p TGFBR2 1.54137391927201 4.15861570449376e-20 -0.433829718000188 0.0135145061644855 miRNATAP -0.288586727900927 2.48780685732294e-11 NA NA NA hsa-miR-501-3p TGFBR2 0.820141346319976 1.74562930463389e-08 -0.433829718000188 0.0135145061644855 TargetScan -0.265130761383748 2.90088382530096e-07 NA NA NA hsa-miR-590-3p TGFBR2 0.221436901462551 0.0965904764063157 -0.433829718000188 0.0135145061644855 miRanda -0.150913065440851 0.00899478950557185 NA NA NA hsa-miR-590-5p TGFBR2 0.763025362395968 3.65305892505623e-09 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.455277845669355 1.52135226951358e-15 NA NA NA hsa-miR-9-5p TGFBR2 1.65694862043766 2.08325802567323e-05 -0.433829718000188 0.0135145061644855 miRNATAP -0.233380460659898 5.34358412799493e-38 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-92a-3p TGFBR2 0.994679542307232 1.32587679156217e-16 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate -0.667598178448999 5.42081269693353e-30 NA NA NA hsa-miR-93-5p TGFBR2 1.61042951896619 5.1280369606967e-24 -0.433829718000188 0.0135145061644855 miRNAWalker2_validate;miRNATAP -0.511432433288783 2.71776456002482e-32 NA NA NA hsa-miR-654-3p TNF -1.77960431554497 1.76486415439529e-14 0.374125718035588 0.15340997881818 miRNATAP -0.177736166803963 0.000196513342903579 NA NA NA hsa-miR-29c-3p TNFRSF1A -2.08166260448948 8.3238369390898e-24 0.138960408487216 0.0940089243204643 MirTarget;miRNATAP -0.134980179214262 6.15978518109614e-17 NA NA NA hsa-miR-27a-3p TP53 0.348456440505425 0.00126682892514312 -0.41755807197951 0.03001853518726 miRNAWalker2_validate -0.202518579356515 0.009421402460679 NA NA NA hsa-miR-146b-5p TRAF6 0.917975986853978 3.33749259316025e-09 -0.335182232467912 0.000449582236780516 miRNAWalker2_validate;MirTarget;PITA;miRanda;miRNATAP -0.123471978106829 2.76328295913158e-06 NA NA NA hsa-miR-15a-5p TRAF6 0.783550182002274 2.60699595655907e-11 -0.335182232467912 0.000449582236780516 MirTarget -0.218714998810595 2.2122117492003e-10 NA NA NA hsa-miR-29a-5p TRAF6 0.323252792625584 0.0370417231222825 -0.335182232467912 0.000449582236780516 MirTarget;mirMAP -0.124324583855682 3.40626954692435e-06 NA NA NA hsa-miR-320a TRAF6 0.801356001806321 4.91397101474502e-09 -0.335182232467912 0.000449582236780516 miRanda -0.13763259568559 4.20160628704609e-06 NA NA NA hsa-miR-374b-5p TRAF6 -0.288413933608091 0.0041474558664058 -0.335182232467912 0.000449582236780516 mirMAP -0.180177437867941 1.43240819890555e-05 NA NA NA hsa-miR-576-5p TRAF6 0.940432050128373 6.90227595663302e-12 -0.335182232467912 0.000449582236780516 mirMAP -0.189867058481985 1.08999403980481e-10 NA NA NA hsa-miR-660-5p TRAF6 -0.202705992887645 0.101093376073573 -0.335182232467912 0.000449582236780516 MirTarget -0.133336440947315 7.93968662327022e-05 NA NA NA