miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p ASPM -0.404413832005229 2.26243409304782e-05 1.14981321245204 5.42741731181426e-08 miRNAWalker2_validate -0.391254936230593 2.72911361574755e-05 NA NA NA hsa-miR-192-5p ASPM -0.467644801315489 1.23713561037949e-07 1.14981321245204 5.42741731181426e-08 miRNAWalker2_validate -0.406638221495092 5.07444023694776e-05 NA NA NA hsa-miR-26b-5p ASPM -0.628946850149209 5.33855198091137e-13 1.14981321245204 5.42741731181426e-08 miRNAWalker2_validate -0.587753405123294 4.11947458610389e-09 NA NA NA hsa-let-7b-5p AURKA -0.752662356167987 1.37877468759762e-13 -0.278264517369762 0.00641667031920347 miRNAWalker2_validate -0.115318862466583 0.00522103280339592 NA NA NA hsa-miR-30c-2-3p AURKA -0.793094392006623 9.55705002627291e-12 -0.278264517369762 0.00641667031920347 MirTarget -0.142541547476743 7.68800934305998e-05 NA NA NA hsa-let-7b-5p BIRC5 -0.752662356167987 1.37877468759762e-13 1.55095077395367 6.04933118671245e-12 miRNAWalker2_validate -0.280856081619741 0.00247340820658831 NA NA NA hsa-miR-186-5p BIRC5 -0.523189799727779 3.08485390148727e-15 1.55095077395367 6.04933118671245e-12 mirMAP -0.436929494630869 0.00220034341342665 NA NA NA hsa-miR-218-5p BIRC5 -0.983625089694874 1.97985523644807e-17 1.55095077395367 6.04933118671245e-12 miRTarBase;MirTarget -0.199080299888751 0.0139168473084584 25473903;25900794;26442524 Survivin BIRC5 was subsequently identified as an important cervical cancer target of miR-218 using in silico prediction mRNA profiling and quantitative real-time PCR qRT-PCR;miR-218 binds survivin BIRC5 mRNA 3'-UTR and down-regulated reporter luciferase activity;MiR-218 promoted apoptosis inhibited cell proliferation and caused cell cycle arrest in CRC cells by suppressing BIRC5 expression; In conclusion we demonstrated that high miR-218 expression had a positive prognostic value in 5-FU-based treatments for CRC patients and discovered a novel mechanism mediated by miR-218 to promote apoptosis and to function synergistically with 5-FU to promote chemosensitivity by suppressing BIRC5 and TS in CRC ;; cervical and endocervical cancer;breast cancer;colorectal cancer hsa-miR-30c-5p BIRC5 -0.627969977524167 3.22684923206531e-09 1.55095077395367 6.04933118671245e-12 miRNAWalker2_validate -0.703826038429428 9.23106216981919e-16 NA NA NA hsa-miR-335-5p BIRC5 -0.499396668742776 3.09730037019673e-06 1.55095077395367 6.04933118671245e-12 miRNAWalker2_validate;MirTarget -0.42422036740769 1.81611389614079e-06 23232114 Genetic variation in a miR 335 binding site in BIRC5 alters susceptibility to lung cancer in Chinese Han populations; In support of the postulation that the 3' UTR SNP may directly affect miRNA-binding site reporter gene assays indicated BIRC5 was a direct target of miR-335 and the rs2239680 T>C change resulted in altered regulation of BIRC5 expression; Our findings defined a 3' UTR SNP in human BIRC5 oncogene that may increase individual susceptibility to lung cancer probably by attenuating the interaction between miR-335 and BIRC5 lung cancer hsa-miR-338-3p BIRC5 -0.31677076686764 0.03678750648526 1.55095077395367 6.04933118671245e-12 miRanda -0.292132173964967 3.6874150512162e-06 NA NA NA hsa-miR-421 BIRC5 -0.399260344693128 0.00042313760487876 1.55095077395367 6.04933118671245e-12 miRanda;mirMAP -0.260665659681237 0.00212062518068653 NA NA NA hsa-miR-542-3p BIRC5 0.230603476698633 0.175807344126122 1.55095077395367 6.04933118671245e-12 miRNAWalker2_validate;MirTarget;miRanda -0.202002783131727 0.000346915751616197 NA NA NA hsa-miR-139-5p BUB1 -1.02294983434508 5.12315145789078e-11 1.75911059635591 2.51998098347075e-17 miRanda -0.5342895665469 1.03443599084159e-22 NA NA NA hsa-miR-186-5p BUB1 -0.523189799727779 3.08485390148727e-15 1.75911059635591 2.51998098347075e-17 miRNAWalker2_validate -0.687882140009106 1.81558413974945e-07 NA NA NA hsa-miR-324-5p BUB1 -0.00405944167668171 0.968216380808326 1.75911059635591 2.51998098347075e-17 MirTarget -0.342326388456657 0.000103154084770497 NA NA NA hsa-miR-542-3p BUB1 0.230603476698633 0.175807344126122 1.75911059635591 2.51998098347075e-17 miRanda -0.288550093801529 3.1853194124672e-08 NA NA NA hsa-let-7b-3p CCNA2 -0.837659434055123 1.82929520690635e-23 0.47872740123165 0.000520159137532747 MirTarget -0.20766521016304 0.00181165760640234 NA NA NA hsa-miR-130a-3p CCNA2 -0.743666387811911 3.82569614390893e-11 0.47872740123165 0.000520159137532747 miRNATAP -0.108491708240153 0.0328833619187407 NA NA NA hsa-miR-22-3p CCNA2 -0.0970774887600179 0.184131447126912 0.47872740123165 0.000520159137532747 MirTarget -0.209490616026077 0.00887851302392956 25596928 The sequence of miR-22 which is conserved in mice rats humans and other mammalians aligns with the sequence of 3'-UTR of CCNA2; Chenodeoxycholic acid treatment and miR-22 mimics reduced CCNA2 protein and increased the number of G0/G1 Huh7 and HCT116 cells; In humans the expression levels of miR-22 and CCNA2 are inversely correlated in liver and colon cancers liver cancer hsa-miR-27b-3p CCNA2 0.269274923049288 0.00111323431173064 0.47872740123165 0.000520159137532747 miRNATAP -0.224079577095692 0.00144162112780766 NA NA NA hsa-miR-374b-5p CCNA2 -0.763713677353164 1.14876879778286e-26 0.47872740123165 0.000520159137532747 mirMAP -0.270504182774343 0.000507211185928065 NA NA NA hsa-miR-486-5p CCNA2 -2.70952059285911 7.86936929104342e-42 0.47872740123165 0.000520159137532747 miRanda -0.109258471511305 4.39927714221106e-05 NA NA NA hsa-miR-98-5p CCNA2 -0.329392203245455 2.71575624645669e-05 0.47872740123165 0.000520159137532747 miRNAWalker2_validate -0.619643358422288 5.95785556486531e-18 NA NA NA hsa-let-7a-5p CCNB2 -0.404413832005229 2.26243409304782e-05 0.885297968517169 1.0925853906853e-10 miRNAWalker2_validate -0.352934206121675 5.00283339380953e-09 NA NA NA hsa-let-7b-5p CCNB2 -0.752662356167987 1.37877468759762e-13 0.885297968517169 1.0925853906853e-10 miRNAWalker2_validate -0.162218115943822 0.0039761272386933 NA NA NA hsa-let-7c-5p CCNB2 -0.697148374832839 3.1238233824316e-12 0.885297968517169 1.0925853906853e-10 miRNAWalker2_validate -0.39565197245671 2.39554431375871e-12 NA NA NA hsa-let-7f-5p CCNB2 -0.290266099287852 0.0310592659201377 0.885297968517169 1.0925853906853e-10 miRNAWalker2_validate -0.218132585014386 4.16356271374171e-07 NA NA NA hsa-miR-23b-3p CCNB2 0.365715415004358 9.88529206526987e-06 0.885297968517169 1.0925853906853e-10 miRNAWalker2_validate -0.321424702639147 4.5311087269495e-06 NA NA NA hsa-miR-192-5p DLGAP5 -0.467644801315489 1.23713561037949e-07 1.72134236974818 5.853117429919e-14 miRNAWalker2_validate -0.480450591991313 1.2307169367402e-05 NA NA NA hsa-miR-192-5p KIF20A -0.467644801315489 1.23713561037949e-07 1.5475527356722 1.84923856323953e-15 miRNAWalker2_validate -0.325000974319196 0.000537710134805777 NA NA NA hsa-miR-374a-5p KIF20A -0.667955123047838 3.28415316034128e-23 1.5475527356722 1.84923856323953e-15 MirTarget -0.348137843876786 0.00381146080973806 NA NA NA hsa-miR-374b-5p KIF20A -0.763713677353164 1.14876879778286e-26 1.5475527356722 1.84923856323953e-15 MirTarget -0.527991871800985 2.31023467448576e-06 NA NA NA hsa-miR-139-5p MAD2L1 -1.02294983434508 5.12315145789078e-11 0.258833441736775 0.00598132857869375 miRanda -0.147347361077121 2.18800267962251e-09 NA NA NA hsa-miR-192-5p MAD2L1 -0.467644801315489 1.23713561037949e-07 0.258833441736775 0.00598132857869375 miRNAWalker2_validate -0.137316694242531 0.00196077036794795 NA NA NA hsa-miR-185-5p NCAPG -0.394881312816397 1.52431794009297e-07 0.94997833269769 3.77642574863913e-07 MirTarget -0.548296089588234 1.30596727841036e-07 NA NA NA hsa-miR-30e-3p NCAPG -0.643210201386468 6.02793074839125e-12 0.94997833269769 3.77642574863913e-07 mirMAP -0.386911134497298 2.98967778336579e-06 NA NA NA hsa-miR-374a-5p NCAPG -0.667955123047838 3.28415316034128e-23 0.94997833269769 3.77642574863913e-07 mirMAP -0.337478352918705 0.00299962896306467 NA NA NA hsa-miR-374b-5p NCAPG -0.763713677353164 1.14876879778286e-26 0.94997833269769 3.77642574863913e-07 mirMAP -0.461778194986553 1.27262702150179e-05 NA NA NA hsa-miR-421 NCAPG -0.399260344693128 0.00042313760487876 0.94997833269769 3.77642574863913e-07 miRNAWalker2_validate -0.217271196950008 0.00182142273134081 NA NA NA hsa-miR-101-5p PBK -0.455398358360624 6.9312777451173e-05 1.48264618953205 7.43900199645402e-14 MirTarget -0.216589606019806 0.00341350714894786 NA NA NA hsa-miR-106a-5p PBK -1.01228908149996 7.64651659779148e-23 1.48264618953205 7.43900199645402e-14 MirTarget -0.252608808909943 0.00147761183963692 NA NA NA hsa-miR-20b-5p PBK -1.55961845090953 3.10041662768317e-18 1.48264618953205 7.43900199645402e-14 MirTarget -0.184937120593947 5.48700436631157e-05 NA NA NA hsa-miR-28-5p PBK -0.9974805781674 7.83766316182713e-45 1.48264618953205 7.43900199645402e-14 miRanda -0.276372332991752 0.0127822656063167 NA NA NA hsa-let-7a-5p RRM2 -0.404413832005229 2.26243409304782e-05 1.38177132498494 6.15487433075539e-12 miRNAWalker2_validate;TargetScan;miRNATAP -0.517212766544491 5.43416273508066e-09 NA NA NA hsa-let-7b-5p RRM2 -0.752662356167987 1.37877468759762e-13 1.38177132498494 6.15487433075539e-12 miRNAWalker2_validate;miRNATAP -0.310556571843713 0.000167520488555949 NA NA NA hsa-let-7d-5p RRM2 -0.255396399267475 4.78398510388426e-05 1.38177132498494 6.15487433075539e-12 miRNATAP -0.789068820682535 6.1616304646279e-09 NA NA NA hsa-let-7e-5p RRM2 0.462155324253583 1.26242915752679e-05 1.38177132498494 6.15487433075539e-12 miRNATAP -0.296581336938065 0.00023182303790925 NA NA NA hsa-let-7f-5p RRM2 -0.290266099287852 0.0310592659201377 1.38177132498494 6.15487433075539e-12 miRNATAP -0.298820874012158 2.43601208914436e-06 NA NA NA hsa-let-7g-5p RRM2 -0.457377035878032 8.57536533990582e-07 1.38177132498494 6.15487433075539e-12 miRNAWalker2_validate;miRNATAP -0.432318078074032 2.19015139778668e-06 NA NA NA hsa-let-7i-5p RRM2 -0.102367263333322 0.264815745470239 1.38177132498494 6.15487433075539e-12 miRNATAP -0.221273555591635 0.0186718276440643 NA NA NA hsa-miR-100-5p RRM2 -1.14800264952058 6.25956711234285e-21 1.38177132498494 6.15487433075539e-12 miRNAWalker2_validate -0.352595382456593 1.51897229453337e-07 NA NA NA hsa-miR-106a-5p RRM2 -1.01228908149996 7.64651659779148e-23 1.38177132498494 6.15487433075539e-12 miRNATAP -0.290298055672228 0.000292333533671198 NA NA NA hsa-miR-125a-5p RRM2 0.453670344724854 2.56876087073382e-06 1.38177132498494 6.15487433075539e-12 miRanda -0.393824838228658 7.79525014361971e-06 NA NA NA hsa-miR-186-5p RRM2 -0.523189799727779 3.08485390148727e-15 1.38177132498494 6.15487433075539e-12 miRNAWalker2_validate -0.447774416273765 0.000422491929040032 NA NA NA hsa-miR-20b-5p RRM2 -1.55961845090953 3.10041662768317e-18 1.38177132498494 6.15487433075539e-12 miRNATAP -0.225060313473723 1.07978706401364e-06 NA NA NA hsa-miR-26a-5p RRM2 -0.777778775731253 6.30887726886301e-29 1.38177132498494 6.15487433075539e-12 miRNAWalker2_validate -0.272907602996608 0.0206357512953809 NA NA NA hsa-miR-30a-5p RRM2 -0.74399827935774 3.33245701644004e-14 1.38177132498494 6.15487433075539e-12 miRNAWalker2_validate -0.947659088006619 1.49515683036992e-31 NA NA NA hsa-miR-30c-5p RRM2 -0.627969977524167 3.22684923206531e-09 1.38177132498494 6.15487433075539e-12 miRNAWalker2_validate -0.801955253178259 1.09538353591844e-25 NA NA NA hsa-miR-362-3p RRM2 -0.52457496268248 7.11877454699199e-06 1.38177132498494 6.15487433075539e-12 miRanda -0.206528130841759 0.00478918971268031 NA NA NA hsa-miR-421 RRM2 -0.399260344693128 0.00042313760487876 1.38177132498494 6.15487433075539e-12 miRanda -0.234373357142873 0.00193246108577389 NA NA NA hsa-miR-484 RRM2 -0.692022486088033 1.64256036970122e-12 1.38177132498494 6.15487433075539e-12 miRNAWalker2_validate -0.211213601119688 0.0142613839925032 NA NA NA hsa-miR-139-5p TOP2A -1.02294983434508 5.12315145789078e-11 1.45892774596127 6.25597269434398e-16 miRanda -0.402837277254764 2.99932771786656e-17 26079880 We identified that miR-139 a previous reported anti-metastatic microRNA targets 3'-untranslated region 3'UTR of TOP2a mRNA; Further more we revealed that the forced expression of miR-139 reduces the TOP2a expression at both mRNA and protein levels; And our functional experiments showed that the ectopic expression of miR-139 remarkably inhibits proliferation in luminal type breast cancer cells while exogenous TOP2a expression could rescue inhibition of cell proliferation mediated by miR-139 breast cancer hsa-miR-186-5p TOP2A -0.523189799727779 3.08485390148727e-15 1.45892774596127 6.25597269434398e-16 miRNAWalker2_validate -0.405787947786262 0.000415288287272957 NA NA NA hsa-miR-542-3p TOP2A 0.230603476698633 0.175807344126122 1.45892774596127 6.25597269434398e-16 miRanda -0.152575348403051 0.000814914476266246 NA NA NA hsa-miR-7-5p TOP2A -3.12544755091643 4.01804346600412e-22 1.45892774596127 6.25597269434398e-16 miRNAWalker2_validate -0.200906158033173 6.95699205998108e-19 NA NA NA hsa-miR-491-5p TPX2 -0.491479103463019 1.91167051131079e-06 1.43077884276138 7.56704852160276e-18 miRanda -0.573360720439935 1.59116091918841e-17 27053618;26279431 miR 491 inhibits the proliferation invasion and migration of hepatocellular carcinoma cell via down regulating TPX2 expression; Overexpression of miR-491 in MHCC-97H cells markedly suppressed cell proliferation invasion and migration and downregulated the protein expression of TPX2; Correlation analysis showed that miR-491 level was negatively correlated with TPX2 expression level in HCC tissues; miR-491 inhibits HCC cell proliferation invasion and migration by downregulating the expression of TPX2;Low Expression of miR 491 Promotes Esophageal Cancer Cell Invasion by Targeting TPX2; The expression of miR-491 and candidate gene TPX2 in EC samples n=99 were detected by RT-PCR; Furthermore we verified that TPX2 was a target gene of miR-491 miR-491 may play a critical role in EC ; liver cancer;esophageal cancer hsa-miR-139-5p TTK -1.02294983434508 5.12315145789078e-11 0.936928833587226 1.49082783783798e-11 miRanda -0.20828231037255 1.81501884693181e-08 NA NA NA hsa-miR-192-5p TTK -0.467644801315489 1.23713561037949e-07 0.936928833587226 1.49082783783798e-11 miRNAWalker2_validate -0.223724118517921 0.000763097429954354 NA NA NA hsa-miR-338-5p TTK -0.394040316969309 0.0102566218856537 0.936928833587226 1.49082783783798e-11 PITA -0.192859870833363 4.64397627549514e-07 NA NA NA