miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-27b-3p ABI2 0.196007704287769 0.295630157035388 -0.645616560842361 4.28966982575571e-07 mirMAP -0.114762985993424 0.000645055117984186 NA NA NA hsa-miR-27b-3p ABL2 0.196007704287769 0.295630157035388 -0.318835189302919 0.0455399452105181 MirTarget;miRNATAP -0.120418681149021 0.0038171424780741 NA NA NA hsa-miR-27b-3p ADAMTS6 0.196007704287769 0.295630157035388 -0.884062586110665 0.0191374035591484 miRNATAP -0.24548223450172 0.0131645401483849 NA NA NA hsa-miR-27b-3p ADCY3 0.196007704287769 0.295630157035388 -0.0890857283182296 0.611682501600207 miRNATAP -0.146185970542526 0.00137558835541352 NA NA NA hsa-miR-27b-3p AFAP1 0.196007704287769 0.295630157035388 -0.984844531728039 0.000121375966999112 miRNATAP -0.156708210943975 0.0204181389124865 NA NA NA hsa-miR-27b-3p ANKRD36B 0.196007704287769 0.295630157035388 0.258166728507682 0.506372831680185 MirTarget -0.293114508579858 0.00388355462342413 NA NA NA hsa-miR-27b-3p ANTXR2 0.196007704287769 0.295630157035388 -2.30617470732809 4.54834840057871e-13 miRNATAP -0.260365488414525 0.00239432989202998 NA NA NA hsa-miR-27b-3p AQP11 0.196007704287769 0.295630157035388 0.609470518793102 0.0124103862238467 MirTarget;miRNATAP -0.180405647483847 0.00473147645604505 NA NA NA hsa-miR-27b-3p ARHGEF6 0.196007704287769 0.295630157035388 -1.31526631626487 3.01617186179318e-06 MirTarget -0.246335644412754 0.000925181238194661 NA NA NA hsa-miR-27b-3p ARNTL 0.196007704287769 0.295630157035388 -0.356733668497135 0.0895626680520666 miRNATAP -0.154208961452845 0.0049850736928727 NA NA NA hsa-miR-27b-3p ATP11C 0.196007704287769 0.295630157035388 -0.478941027537111 0.00362613242454584 MirTarget;miRNATAP -0.145378784572387 0.000728261535134485 NA NA NA hsa-miR-27b-3p BRPF3 0.196007704287769 0.295630157035388 0.0256488902279868 0.871915877210081 MirTarget;miRNATAP -0.127800257992608 0.00202461998614367 NA NA NA hsa-miR-27b-3p BRSK1 0.196007704287769 0.295630157035388 -1.1945411262043 0.00300596258667475 MirTarget;miRNATAP -0.208063045123729 0.0496540328933945 NA NA NA hsa-miR-27b-3p CALM3 0.196007704287769 0.295630157035388 -0.263120000307818 0.021397203177678 miRNAWalker2_validate;miRNATAP -0.102996061954588 0.00052761268410962 NA NA NA hsa-miR-27b-3p CBX5 0.196007704287769 0.295630157035388 -0.138407155575337 0.490229654374752 miRNATAP -0.124075123216309 0.0179255726070182 NA NA NA hsa-miR-27b-3p CCDC50 0.196007704287769 0.295630157035388 -0.784992887432969 4.78414891397232e-08 mirMAP -0.155296037027583 4.16969017960847e-05 NA NA NA hsa-miR-27b-3p CCM2 0.196007704287769 0.295630157035388 0.502144371107641 0.00152658387679893 MirTarget;miRNATAP -0.129348024613207 0.001815391902621 NA NA NA hsa-miR-27b-3p CCND3 0.196007704287769 0.295630157035388 0.142518749044219 0.397307080616203 miRNAWalker2_validate -0.133645004740845 0.00231237621077374 NA NA NA hsa-miR-27b-3p CD28 0.196007704287769 0.295630157035388 -1.38038134905538 0.000840093133243443 miRNATAP -0.224926962768183 0.0389961293032109 NA NA NA hsa-miR-27b-3p CD84 0.196007704287769 0.295630157035388 -0.533438552489043 0.279469755133035 mirMAP -0.323294609177477 0.0122832473044153 NA NA NA hsa-miR-27b-3p CDC25B 0.196007704287769 0.295630157035388 0.783166040527924 0.00478680511553999 miRNATAP -0.184322560063894 0.0114592631260318 NA NA NA hsa-miR-27b-3p CPPED1 0.196007704287769 0.295630157035388 -0.720118533104011 0.0333995163848173 MirTarget -0.278721328132275 0.00164907119417506 NA NA NA hsa-miR-27b-3p CRTC1 0.196007704287769 0.295630157035388 -0.422754023154988 0.0112988213002957 miRNATAP -0.101992138655305 0.0196481050618103 NA NA NA hsa-miR-27b-3p CSF1 0.196007704287769 0.295630157035388 -1.29812834960066 0.000329197071112557 MirTarget;miRNATAP -0.392660450968279 3.33841189043943e-05 NA NA NA hsa-miR-27b-3p DCHS2 0.196007704287769 0.295630157035388 -3.63284596332258 2.50785525526847e-13 MirTarget -0.326257703983828 0.0149096881664305 NA NA NA hsa-miR-27b-3p DLL4 0.196007704287769 0.295630157035388 -0.139131639340646 0.545577826577643 miRNATAP -0.12436919745502 0.0389100696889613 NA NA NA hsa-miR-27b-3p EIF2AK2 0.196007704287769 0.295630157035388 0.89012273997551 1.37735288077564e-05 mirMAP -0.165471996583644 0.00216768057718027 NA NA NA hsa-miR-27b-3p FAM120C 0.196007704287769 0.295630157035388 -0.22055823829091 0.20934361760389 mirMAP;miRNATAP -0.129559299369108 0.00470796130855341 NA NA NA hsa-miR-27b-3p FAM184A 0.196007704287769 0.295630157035388 -1.88365850575461 1.47300194053988e-05 MirTarget -0.379382956607139 0.000937418572332123 NA NA NA hsa-miR-27b-3p FAM65B 0.196007704287769 0.295630157035388 -1.55548615457252 4.5474203363756e-05 miRNATAP -0.258761308184129 0.0101992993654527 NA NA NA hsa-miR-27b-3p FAM78A 0.196007704287769 0.295630157035388 -0.17566660865732 0.571673572062009 MirTarget;miRNATAP -0.228230559562808 0.00491106640044871 NA NA NA hsa-miR-27b-3p FRS3 0.196007704287769 0.295630157035388 0.407697287106881 0.0097672393506347 MirTarget;miRNATAP -0.133725081124864 0.00117145415737577 NA NA NA hsa-miR-27b-3p FYN 0.196007704287769 0.295630157035388 -1.46508592139092 9.74677213788621e-08 miRNATAP -0.295908382595112 4.57840520014776e-05 NA NA NA hsa-miR-27b-3p FZD4 0.196007704287769 0.295630157035388 -0.82842258037894 0.00067769989049317 miRNATAP -0.181363436048367 0.0046411443483725 NA NA NA hsa-miR-27b-3p GNAZ 0.196007704287769 0.295630157035388 -2.94665194856656 9.29748758880407e-10 miRNATAP -0.267048201635189 0.0382539477811624 NA NA NA hsa-miR-27b-3p GNS 0.196007704287769 0.295630157035388 -0.108313583740261 0.467404007057302 miRNATAP -0.114208010113405 0.00324826283300982 NA NA NA hsa-miR-27b-3p GOLM1 0.196007704287769 0.295630157035388 0.831440388262659 0.000164724138856932 MirTarget -0.147949118665012 0.0109095744956898 25115396 GOLM1 was directly regulated by miR-27b in PCa cells prostate cancer hsa-miR-27b-3p GPR180 0.196007704287769 0.295630157035388 0.729962865071142 4.30145915914005e-06 mirMAP -0.118380420037474 0.00471528767065912 NA NA NA hsa-miR-27b-3p H2AFZ 0.196007704287769 0.295630157035388 0.709807851550213 6.96802858399962e-06 miRNATAP -0.106294887488852 0.0107413570165145 NA NA NA hsa-miR-27b-3p HDX 0.196007704287769 0.295630157035388 -1.0807292079556 0.00225613614508647 miRNATAP -0.262473963621288 0.00474461552728139 NA NA NA hsa-miR-27b-3p HIP1 0.196007704287769 0.295630157035388 -0.474182622773849 0.0554905092137366 mirMAP;miRNATAP -0.200043658457145 0.00199479138732379 NA NA NA hsa-miR-27b-3p HIPK2 0.196007704287769 0.295630157035388 -0.569766486297519 0.0176403507362252 miRNATAP -0.15881843468458 0.011623243365 NA NA NA hsa-miR-27b-3p HIVEP3 0.196007704287769 0.295630157035388 0.0288071997334853 0.920325184162576 MirTarget;miRNATAP -0.315627226909289 2.43195888855256e-05 NA NA NA hsa-miR-27b-3p IKZF1 0.196007704287769 0.295630157035388 -1.30628932919626 0.00159566603720278 miRNATAP -0.30648854832552 0.00483401501185332 NA NA NA hsa-miR-27b-3p IQCE 0.196007704287769 0.295630157035388 0.000358330812253449 0.998277674841503 mirMAP -0.115713293959944 0.00749986980368437 NA NA NA hsa-miR-27b-3p IQGAP2 0.196007704287769 0.295630157035388 -1.52360294157558 3.06082893161956e-05 MirTarget -0.301582536015229 0.00174919422983944 NA NA NA hsa-miR-27b-3p JAZF1 0.196007704287769 0.295630157035388 -1.91995536790338 5.72076669427973e-12 miRNATAP -0.164667239234178 0.0281108548011036 NA NA NA hsa-miR-27b-3p KATNA1 0.196007704287769 0.295630157035388 -0.243807589975254 0.0459106945585719 MirTarget -0.114242950134934 0.000316119626498377 NA NA NA hsa-miR-27b-3p KCTD14 0.196007704287769 0.295630157035388 0.898281965985512 0.0375161599626591 MirTarget -0.604097548136707 6.40455192617755e-08 NA NA NA hsa-miR-27b-3p KIF21B 0.196007704287769 0.295630157035388 0.413214989103221 0.121506779546135 miRNATAP -0.161587277336157 0.0207617348119908 NA NA NA hsa-miR-27b-3p KLF12 0.196007704287769 0.295630157035388 -1.46917100719464 1.42059321169598e-05 mirMAP -0.21035193981268 0.0188004877376784 NA NA NA hsa-miR-27b-3p KLHDC3 0.196007704287769 0.295630157035388 0.583955808934718 2.61743888491629e-05 miRNATAP -0.103639154535507 0.00454202495660556 NA NA NA hsa-miR-27b-3p LBR 0.196007704287769 0.295630157035388 -0.518593985750688 0.000861346810901376 MirTarget -0.211257316401988 1.6298442267597e-07 NA NA NA hsa-miR-27b-3p LIFR 0.196007704287769 0.295630157035388 -2.63259527057529 1.38063075823569e-10 MirTarget;miRNATAP -0.325642645121511 0.00300387226119738 NA NA NA hsa-miR-27b-3p LPIN1 0.196007704287769 0.295630157035388 -0.89601675169461 0.000133989377531311 miRNATAP -0.228395827033324 0.000206896567788123 NA NA NA hsa-miR-27b-3p MAP3K12 0.196007704287769 0.295630157035388 -0.856121644680553 0.00031269192719719 miRNATAP -0.169002104388256 0.00684605130645394 NA NA NA hsa-miR-27b-3p MARCH1 0.196007704287769 0.295630157035388 0.249895584717324 0.347593448523703 miRNATAP -0.221015936054471 0.00145218187380443 NA NA NA hsa-miR-27b-3p MEF2C 0.196007704287769 0.295630157035388 -2.13436808535659 1.07833769123274e-14 miRNATAP -0.237786374937992 0.00142852292617996 NA NA NA hsa-miR-27b-3p MMD 0.196007704287769 0.295630157035388 -0.0500962943374854 0.870546787744501 miRNATAP -0.267238066664607 0.000854151564548078 NA NA NA hsa-miR-27b-3p NAV1 0.196007704287769 0.295630157035388 -0.418200324441875 0.108742163308665 miRNATAP -0.179386559636668 0.00855233805072866 NA NA NA hsa-miR-27b-3p NCOA7 0.196007704287769 0.295630157035388 -1.35089729695581 3.29762011021499e-07 miRNATAP -0.150695208871036 0.0320442931039773 NA NA NA hsa-miR-27b-3p NDUFS6 0.196007704287769 0.295630157035388 0.691967838503034 7.58276460273031e-05 miRNAWalker2_validate -0.104125942677351 0.02384807330943 NA NA NA hsa-miR-27b-3p NFIB 0.196007704287769 0.295630157035388 -1.72909658442002 3.18902339154006e-09 mirMAP;miRNATAP -0.205155435787951 0.00844177205602101 NA NA NA hsa-miR-27b-3p NR5A2 0.196007704287769 0.295630157035388 -1.30745675590419 3.0949312510936e-06 miRNATAP -0.331604649123085 6.62680748578708e-06 NA NA NA hsa-miR-27b-3p OAF 0.196007704287769 0.295630157035388 -0.845656604849646 5.25894410382958e-05 MirTarget -0.128435596321665 0.0199155919967402 NA NA NA hsa-miR-27b-3p ORAI2 0.196007704287769 0.295630157035388 0.424831459887377 0.0225669671371785 mirMAP -0.12084154878248 0.013227634674716 NA NA NA hsa-miR-27b-3p PALM2 0.196007704287769 0.295630157035388 0.556813445440219 0.127115395747529 MirTarget -0.313843924379153 0.000993202816017433 NA NA NA hsa-miR-27b-3p PAX6 0.196007704287769 0.295630157035388 -0.0440427707484987 0.892699851474819 mirMAP -0.297239733667526 0.000476106003192727 NA NA NA hsa-miR-27b-3p PDHX 0.196007704287769 0.295630157035388 -0.161030738384195 0.219886598227024 MirTarget;miRNATAP -0.109783995481437 0.00129196230085006 NA NA NA hsa-miR-27b-3p PDK4 0.196007704287769 0.295630157035388 -4.43413379327996 1.13465040553705e-21 MirTarget -0.303225313177499 0.0177824374948418 NA NA NA hsa-miR-27b-3p PDS5B 0.196007704287769 0.295630157035388 -0.331602343603587 0.0229868322529022 MirTarget;miRNATAP -0.113250538052061 0.00292757107579183 NA NA NA hsa-miR-27b-3p PHLPP2 0.196007704287769 0.295630157035388 -0.542526414508152 0.00198752699211246 MirTarget;miRNATAP -0.119293139380493 0.00955119674767794 NA NA NA hsa-miR-27b-3p PLCL2 0.196007704287769 0.295630157035388 -0.707086905408937 0.0474072991672256 miRNATAP -0.351733840693443 0.000156486707790538 NA NA NA hsa-miR-27b-3p PLXND1 0.196007704287769 0.295630157035388 -0.249571892931558 0.281209187171312 MirTarget;miRNATAP -0.209310408698164 0.000522865798154634 NA NA NA hsa-miR-27b-3p PODXL 0.196007704287769 0.295630157035388 0.0414443420695312 0.863766861702909 mirMAP -0.207513692173628 0.000977632580077736 NA NA NA hsa-miR-27b-3p PSMA1 0.196007704287769 0.295630157035388 0.277117855154859 0.0102849594055575 MirTarget -0.118354472569573 2.30689750852057e-05 NA NA NA hsa-miR-27b-3p RFX3 0.196007704287769 0.295630157035388 -0.241590723666582 0.329077356141378 mirMAP;miRNATAP -0.16088252267911 0.0129302431765232 NA NA NA hsa-miR-27b-3p RNF24 0.196007704287769 0.295630157035388 0.565594120068294 0.00298977951504636 mirMAP -0.106331256321454 0.0336095124852979 NA NA NA hsa-miR-27b-3p ROR1 0.196007704287769 0.295630157035388 -3.30918955622389 8.44697749058312e-11 MirTarget;miRNATAP -0.31750590065766 0.0202366853523201 26576539 Bioinformatic prediction luciferase reporter assay quantitative real-time PCR qRT-PCR and western blotting were used to reveal the regulatory relationship between miR-27b-3p and ROR1; The expression patterns of miR-27b-3p and ROR1 in human gastric cancer GC specimens and cell lines were determined by microRNA RT-PCR and western blotting; miR-27b-3p suppressed ROR1 expression by binding to the 3'UTR of ROR1 mRNA in GC cells; miR-27b-3p was significantly downregulated and reversely correlated with ROR1 protein levels in clinical samples; Analysis of the clinicopathological significance showed that miR-27b-3p and ROR1 were closely correlated with GC characteristics; These results show that miR-27b-3p suppresses ROR1 expression through the binding site in the 3'UTR inhibiting the cell proliferation; These findings indicate that miR-27b-3p exerts tumor-suppressive effects in GC through the suppression of oncogene ROR1 expression and suggest a therapeutic application of miR-27b-3p in GC gastric cancer hsa-miR-27b-3p RSAD2 0.196007704287769 0.295630157035388 1.09050448915747 0.0183343807979865 MirTarget -0.366454471360531 0.00248254049203547 NA NA NA hsa-miR-27b-3p SGTB 0.196007704287769 0.295630157035388 -0.742273008815391 0.00179777008986928 MirTarget -0.163819187711315 0.00872251095185215 NA NA NA hsa-miR-27b-3p SH2D3C 0.196007704287769 0.295630157035388 -0.688549678845823 0.00308130527239945 miRNATAP -0.191131889642226 0.00171955449940275 NA NA NA hsa-miR-27b-3p SLC39A13 0.196007704287769 0.295630157035388 0.238808820316581 0.13007352234209 miRNATAP -0.153235820881256 0.000186088397558676 NA NA NA hsa-miR-27b-3p SLC43A1 0.196007704287769 0.295630157035388 -1.4944308564938 7.22603502597254e-06 miRNAWalker2_validate -0.240833300045848 0.00624324860883682 NA NA NA hsa-miR-27b-3p SLC8A1 0.196007704287769 0.295630157035388 -2.45338438529403 5.46491423919659e-12 MirTarget -0.240948342015702 0.0118098214042578 NA NA NA hsa-miR-27b-3p SLFN11 0.196007704287769 0.295630157035388 -0.526738853438438 0.153699831151944 MirTarget -0.285423300647139 0.00310988184070325 NA NA NA hsa-miR-27b-3p SLFN5 0.196007704287769 0.295630157035388 -0.756453966970185 0.00885190121251301 MirTarget -0.189098805263786 0.0126641023460408 NA NA NA hsa-miR-27b-3p SNN 0.196007704287769 0.295630157035388 -0.434630874607479 0.026982293104271 miRNATAP -0.102818369913979 0.0459816809521664 NA NA NA hsa-miR-27b-3p SNX10 0.196007704287769 0.295630157035388 1.54337247106093 9.6883325994053e-07 miRNATAP -0.476075082932933 7.05505677055588e-09 NA NA NA hsa-miR-27b-3p SPATA13 0.196007704287769 0.295630157035388 -0.767050914042862 0.0429268491450044 miRNATAP -0.210377481082523 0.0343733498917012 NA NA NA hsa-miR-27b-3p ST6GALNAC3 0.196007704287769 0.295630157035388 -2.04578308207892 3.03442932816697e-11 MirTarget -0.166739218094937 0.0438051959855721 NA NA NA hsa-miR-27b-3p TEAD1 0.196007704287769 0.295630157035388 -1.49495998391161 1.96516757915294e-13 miRNATAP -0.141176393709149 0.00999060008987025 NA NA NA hsa-miR-27b-3p TMEM170B 0.196007704287769 0.295630157035388 -0.889417316317811 0.00246966185092237 MirTarget;miRNATAP -0.204282946023407 0.0081368097863443 NA NA NA hsa-miR-27b-3p TMSB10 0.196007704287769 0.295630157035388 1.09657415560839 1.87323216871511e-06 miRNATAP -0.190038259152998 0.00176957477330669 NA NA NA hsa-miR-27b-3p TNFRSF1B 0.196007704287769 0.295630157035388 -0.733402255800926 0.0116013403475287 mirMAP -0.228739236342458 0.00265591000088912 NA NA NA hsa-miR-27b-3p TRIM21 0.196007704287769 0.295630157035388 0.0892860883529307 0.654037206784383 MirTarget -0.219253775804871 2.19821952129445e-05 NA NA NA hsa-miR-27b-3p USP13 0.196007704287769 0.295630157035388 -0.643196805157028 0.00602056998807648 mirMAP -0.248323337437884 4.79683810961751e-05 NA NA NA hsa-miR-27b-3p USP51 0.196007704287769 0.295630157035388 -1.32123324806179 0.000170137081757853 MirTarget;miRNATAP -0.27949221516474 0.00251757359203482 NA NA NA hsa-miR-27b-3p VEGFC 0.196007704287769 0.295630157035388 -0.457873556695705 0.178610332401836 MirTarget -0.184894953706514 0.038219701457811 23593282 We identified vascular endothelial growth factor C VEGFC as a novel target gene of miR-27b and determined that miR-27b functioned as an inhibitor of tumor progression and angiogenesis through targeting VEGFC in CRC; In summary an anti-tumor role for miR-27b and its novel target VEGFC in vivo could lead to tumor necrosis and provide a rationale for developing miR-27b as a therapeutic agent progression colorectal cancer hsa-miR-27b-3p WDR35 0.196007704287769 0.295630157035388 -0.40953801370308 0.0157521829552618 MirTarget -0.124141080750709 0.00513312054233093 NA NA NA hsa-miR-27b-3p ZC3H12D 0.196007704287769 0.295630157035388 -0.16671548746032 0.680459988424941 MirTarget -0.279329962125485 0.00831352062728761 NA NA NA hsa-miR-27b-3p ZEB2 0.196007704287769 0.295630157035388 -2.26388876645177 1.13775147583663e-12 miRNATAP -0.25970403203108 0.00240590967731218 NA NA NA