miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-155-5p	APAF1	2.81443182173772	7.42530504828797e-05	0.351537995191827	0.33130839684909	miRNAWalker2_validate	-0.105119871128062	0.000202319072259625	22996741;26877850	MiR 155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of Apaf 1 expression; The objective of this study is to verify the hypothesis based on the results of bioinformatics analysis that miR-155 modulates cellular apoptosis and DNA damage through the regulation of Apaf-1 and is thus involved in the development and progression of lung cancer; First we measured the expression of miR-155 and the Apaf-1 protein in lung cancer tissues; The results showed that expression of miR-155 was significantly higher in lung cancer tissues than in paracancerous and normal tissues; whereas Apaf-1 expression was lower in the lung cancerous tissues; The results showed that relative to controls the silencing of miR-155 resulted in elevated expression of the Apaf-1 protein whereas Apaf-1 mRNA levels remained unchanged; Both the silencing of miR-155 and the overexpression Apaf-1 greatly increased the sensitivity of A549 cells to cisplatin treatment as evidenced by elevated rates of apoptosis and DNA damage; Furthermore dual-transfection of A549 cells with miR-155 siRNA and Apaf-1 siRNA resulted in the attenuation of apoptosis and DNA damage;Also increase in the transcript level of APAF-1 and CASP-9 after downregulation of miR-21 and miR-155 might indicate that these genes were targeted by aforementioned miRNAs in T47D cells	progression;	lung cancer;breast cancer
hsa-miR-23a-3p	APAF1	0.925125296618358	0.0127293543936914	0.351537995191827	0.33130839684909	miRNATAP	-0.249229585742285	6.24449355106243e-06	24992592;24249161	Luciferase assay was performed to verify a putative target site of miR-23a in the 3'-UTR of apoptosis protease activating factor 1 APAF1 mRNA; The expression levels of miR-23a and APAF1 in CRC cell lines SW480 and SW620 and clinical samples were assessed using reverse transcription-quantitative real-time PCR RT-qPCR and Western blot; Moreover miR-23a up-regulation was coupled with APAF1 down-regulation in CRC tissue samples;We found that the expression of miR-23a was increased and the level of apoptosis-activating factor-1 APAF-1 was decreased in 5-FU-treated colon cancer cells compared to untreated cells; APAF-1 as a target gene of miR-23a was identified and miR-23a antisense-induced increase in the activation of caspase-9 was observed	;	colorectal cancer;colorectal cancer
hsa-miR-23b-3p	APAF1	-0.581135273821923	0.190478897170459	0.351537995191827	0.33130839684909	miRNATAP	-0.161636616309506	0.000480979993890262		NA	NA	NA
hsa-miR-27a-3p	APAF1	1.76094007417453	0.000216137556256765	0.351537995191827	0.33130839684909	miRNATAP	-0.178590051704588	2.61315263276561e-05		NA	NA	NA
hsa-miR-27b-3p	APAF1	-0.0929089601968123	0.85847352206581	0.351537995191827	0.33130839684909	miRNATAP	-0.157888261033241	5.61389496165659e-05		NA	NA	NA
hsa-miR-590-3p	APAF1	2.35429565068338	2.79601879608564e-06	0.351537995191827	0.33130839684909	PITA;miRanda;mirMAP;miRNATAP	-0.117753147962954	0.00340114353110643		NA	NA	NA
hsa-miR-708-3p	APAF1	0.781444321399141	0.290645825716608	0.351537995191827	0.33130839684909	mirMAP	-0.116215085120532	2.19939409004865e-05		NA	NA	NA
hsa-miR-203a-3p	ATM	6.35084246337388	7.89944323347948e-08	-0.658961239426083	0.11688259993407	MirTarget	-0.10711538788314	2.54510630277939e-08	24145123;27542403	miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM;MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression	drug resistance;metastasis	colorectal cancer;gastric cancer
hsa-miR-27a-5p	ATM	1.44543293228138	0.039420863458837	-0.658961239426083	0.11688259993407	MirTarget	-0.118013745915902	0.000461560887135157		NA	NA	NA
hsa-miR-30e-3p	ATM	-0.0362193022195196	0.932577027239525	-0.658961239426083	0.11688259993407	mirMAP	-0.157523794415466	0.00510124349387628		NA	NA	NA
hsa-miR-339-5p	ATM	1.23326828594484	0.0307501214818698	-0.658961239426083	0.11688259993407	miRanda	-0.155925656284305	0.000170742871820193		NA	NA	NA
hsa-miR-590-5p	ATM	1.51400888103768	0.0023888567923017	-0.658961239426083	0.11688259993407	mirMAP	-0.134411712770607	0.00484636149427119		NA	NA	NA
hsa-miR-29a-5p	ATR	0.0748295222568571	0.884125894063293	1.11653396152035	0.00117645494644219	mirMAP	-0.128755734022869	0.000765927974508895		NA	NA	NA
hsa-miR-30a-5p	ATR	-0.768430903969183	0.320487552854215	1.11653396152035	0.00117645494644219	mirMAP	-0.113875244097274	5.31462122478425e-06		NA	NA	NA
hsa-miR-139-5p	BBC3	-2.09475477693654	0.000382570602748311	0.475293229786881	0.35789989855877	miRNATAP	-0.156907185873873	0.00142876640678516		NA	NA	NA
hsa-let-7a-5p	CCND1	0.148081801547773	0.645305441523746	0.153161422157864	0.87752763573474	TargetScan;miRNATAP	-0.543758028087025	0.00245174452713361		NA	NA	NA
hsa-miR-106a-5p	CCND1	3.98693608217557	9.37722470816656e-07	0.153161422157864	0.87752763573474	MirTarget;miRNATAP	-0.430943892321887	6.82894757639655e-11		NA	NA	NA
hsa-miR-15a-5p	CCND1	2.0535411006904	1.91108976398046e-06	0.153161422157864	0.87752763573474	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.345671894500985	0.00776019225008181	22922827	CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR		sarcoma
hsa-miR-15b-5p	CCND1	3.32329949959268	8.40210501034588e-13	0.153161422157864	0.87752763573474	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.423468924188888	0.000292921876666624		NA	NA	NA
hsa-miR-20b-5p	CCND1	4.5662923200279	4.75238200639144e-05	0.153161422157864	0.87752763573474	MirTarget;miRNATAP	-0.306916825629866	1.73283870424345e-10		NA	NA	NA
hsa-miR-34a-5p	CCND1	0.830377770217786	0.0477544831885907	0.153161422157864	0.87752763573474	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.423813778518534	0.00174350326234822	25792709;21399894	This inhibition of proliferation was associated with a decrease in cyclin D1 levels orchestrated principally by HNF-4α a target of miR-34a considered to act as a tumour suppressor in the liver;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a	;	liver cancer;breast cancer
hsa-miR-497-5p	CCND1	-1.44150596209372	0.0225146607606395	0.153161422157864	0.87752763573474	MirTarget;miRNATAP	-0.249933846887954	0.00498383887238102	21350001	Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer		breast cancer
hsa-miR-106a-5p	CCND2	3.98693608217557	9.37722470816656e-07	-2.81051675901102	0.00139983736368543	miRNATAP	-0.444958981451041	2.08537025757115e-14		NA	NA	NA
hsa-miR-106b-5p	CCND2	2.80565545918114	1.14547999022566e-09	-2.81051675901102	0.00139983736368543	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.309595760343179	0.00374413339981401		NA	NA	NA
hsa-miR-10a-3p	CCND2	0.970411431936568	0.31667483998251	-2.81051675901102	0.00139983736368543	mirMAP	-0.203238239783698	0.000109626077062705		NA	NA	NA
hsa-miR-130b-5p	CCND2	3.74118449312296	2.92266550966038e-10	-2.81051675901102	0.00139983736368543	mirMAP	-0.460499923117218	1.14695292180331e-08		NA	NA	NA
hsa-miR-141-3p	CCND2	7.30474126597325	1.45115996357606e-24	-2.81051675901102	0.00139983736368543	MirTarget;TargetScan	-0.239696704303332	0.000205435786708848		NA	NA	NA
hsa-miR-15b-5p	CCND2	3.32329949959268	8.40210501034588e-13	-2.81051675901102	0.00139983736368543	miRNATAP	-0.527059068245043	3.31921597840683e-07		NA	NA	NA
hsa-miR-16-2-3p	CCND2	3.79845098071094	1.49120139344659e-13	-2.81051675901102	0.00139983736368543	mirMAP	-0.289719520581	0.00206680066165107		NA	NA	NA
hsa-miR-182-5p	CCND2	5.86988712704738	1.22411588571584e-15	-2.81051675901102	0.00139983736368543	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.278474368736704	1.61949004264047e-05		NA	NA	NA
hsa-miR-183-5p	CCND2	6.61903249270777	1.00958881445636e-16	-2.81051675901102	0.00139983736368543	miRNATAP	-0.288028240113034	1.0097840608077e-06		NA	NA	NA
hsa-miR-191-5p	CCND2	1.58824208483839	0.000738859004053681	-2.81051675901102	0.00139983736368543	MirTarget	-0.315151097931825	0.00313941450228982		NA	NA	NA
hsa-miR-200a-3p	CCND2	6.336081120041	4.024313571871e-16	-2.81051675901102	0.00139983736368543	MirTarget	-0.414829241668513	2.52639559759353e-12		NA	NA	NA
hsa-miR-20b-5p	CCND2	4.5662923200279	4.75238200639144e-05	-2.81051675901102	0.00139983736368543	miRNATAP	-0.295383995634395	4.37719472717441e-12		NA	NA	NA
hsa-miR-224-3p	CCND2	2.84876340814503	0.000179138399939161	-2.81051675901102	0.00139983736368543	mirMAP	-0.216162489376406	0.00100829595274067		NA	NA	NA
hsa-miR-28-5p	CCND2	-0.815636722979196	0.0221199948901761	-2.81051675901102	0.00139983736368543	miRanda	-0.428938814049462	0.00272604774130058		NA	NA	NA
hsa-miR-3065-3p	CCND2	1.89496019576082	0.0308154823923145	-2.81051675901102	0.00139983736368543	MirTarget;miRNATAP	-0.206941274598462	0.000265009133802388		NA	NA	NA
hsa-miR-3065-5p	CCND2	2.14185373842821	0.0609400502269891	-2.81051675901102	0.00139983736368543	mirMAP	-0.198616424838265	0.000257635954140166		NA	NA	NA
hsa-miR-30d-3p	CCND2	-0.0740421896025512	0.857423650167556	-2.81051675901102	0.00139983736368543	mirMAP	-0.548341190913964	7.47249707616609e-06		NA	NA	NA
hsa-miR-324-3p	CCND2	1.51345381556672	0.0038447546677657	-2.81051675901102	0.00139983736368543	miRNAWalker2_validate	-0.43719832262749	4.09891269304966e-06		NA	NA	NA
hsa-miR-33a-3p	CCND2	2.06269680799532	0.00156436055383943	-2.81051675901102	0.00139983736368543	MirTarget	-0.270924955791957	0.000410846654094401		NA	NA	NA
hsa-miR-378a-3p	CCND2	1.46612141870273	0.0466660641196872	-2.81051675901102	0.00139983736368543	miRNAWalker2_validate	-0.186901666998984	0.00600686499792038		NA	NA	NA
hsa-miR-429	CCND2	6.39965293994036	1.96920201593608e-18	-2.81051675901102	0.00139983736368543	miRNATAP	-0.457780562605429	2.24817157133262e-13		NA	NA	NA
hsa-miR-497-5p	CCND2	-1.44150596209372	0.0225146607606395	-2.81051675901102	0.00139983736368543	MirTarget;miRNATAP	-0.272420525595686	0.000579324260115001		NA	NA	NA
hsa-miR-550a-5p	CCND2	1.21781238856895	0.0613791144699551	-2.81051675901102	0.00139983736368543	MirTarget	-0.224646283844048	0.00363403467531415		NA	NA	NA
hsa-miR-660-5p	CCND2	-0.0668683798854808	0.885250178390404	-2.81051675901102	0.00139983736368543	mirMAP	-0.290960137515711	0.00793054638018279		NA	NA	NA
hsa-miR-9-3p	CCND2	1.69328215716742	0.125170982657059	-2.81051675901102	0.00139983736368543	MirTarget;mirMAP;miRNATAP	-0.143162485603445	0.00185116011719342		NA	NA	NA
hsa-miR-93-5p	CCND2	2.65964181833033	2.58315947526774e-08	-2.81051675901102	0.00139983736368543	miRNATAP	-0.48060449639845	2.62594110203289e-06		NA	NA	NA
hsa-miR-96-5p	CCND2	5.62521466029286	1.54938806718028e-10	-2.81051675901102	0.00139983736368543	TargetScan;miRNATAP	-0.24395409924335	0.000303822796805944		NA	NA	NA
hsa-miR-27b-3p	CCND3	-0.0929089601968123	0.85847352206581	-0.53759657598867	0.124370433214632	miRNAWalker2_validate	-0.141758210053908	0.000190546260809965		NA	NA	NA
hsa-miR-429	CCND3	6.39965293994036	1.96920201593608e-18	-0.53759657598867	0.124370433214632	miRNATAP	-0.112877673525875	7.62633278325715e-06		NA	NA	NA
hsa-miR-96-5p	CCND3	5.62521466029286	1.54938806718028e-10	-0.53759657598867	0.124370433214632	TargetScan	-0.116905111437921	9.66017245986979e-06		NA	NA	NA
hsa-miR-125b-5p	CCNE1	-2.01187572101832	0.00516480893645494	3.90668327437123	7.68546937179809e-18	miRNAWalker2_validate	-0.127872185036842	0.000654725383789322		NA	NA	NA
hsa-miR-195-5p	CCNE1	-1.59182537400701	0.0169128463756769	3.90668327437123	7.68546937179809e-18	miRNAWalker2_validate;MirTarget;miRNATAP	-0.11514367249823	0.00470453662143774	24402230	Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively		breast cancer
hsa-miR-26a-5p	CCNE1	-0.352368463397074	0.362040749917446	3.90668327437123	7.68546937179809e-18	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.184731728950396	0.00988349874140469	22094936	Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen		breast cancer
hsa-miR-497-5p	CCNE1	-1.44150596209372	0.0225146607606395	3.90668327437123	7.68546937179809e-18	MirTarget;miRNATAP	-0.126936185159413	0.00315358484504579	24909281;24112607;25909221	miR 497 suppresses proliferation of human cervical carcinoma HeLa cells by targeting cyclin E1; Furthermore the target effect of miR-497 on the CCNE1 was identified by dual-luciferase reporter assay system qRT-PCR and Western blotting; Over-expressed miR-497 in HeLa cells could suppress cell proliferation by targeting CCNE1;Western blot assays confirmed that overexpression of miR-497 reduced cyclin E1 protein levels; Inhibited cellular growth suppressed cellular migration and invasion and G1 cell cycle arrest were observed upon overexpression of miR-497 in cells possibly by targeting cyclin E1;The effect of simultaneous overexpression of miR-497 and miR-34a on the inhibition of cell proliferation colony formation and tumor growth and the downregulation of cyclin E1 was stronger than the effect of each miRNA alone; The synergistic actions of miR-497 and miR-34a partly correlated with cyclin E1 levels; These results indicate cyclin E1 is downregulated by both miR-497 and miR-34a which synergistically retard the growth of human lung cancer cells	;;	cervical and endocervical cancer;breast cancer;lung cancer
hsa-miR-28-3p	CCNE2	-0.992446114847535	0.0188188359018203	4.77667612901641	6.489939090147e-18	PITA;miRNATAP	-0.212700603723915	0.00739021768839842		NA	NA	NA
hsa-miR-30a-5p	CCNE2	-0.768430903969183	0.320487552854215	4.77667612901641	6.489939090147e-18	miRNATAP	-0.229409802316148	5.49447336865621e-08		NA	NA	NA
hsa-miR-142-3p	CCNG1	4.35304505457969	3.10014573651358e-10	-1.09796577928737	0.00345685886529286	miRanda	-0.10252596610983	0.000588407752346411		NA	NA	NA
hsa-miR-142-5p	CCNG1	3.95552531913424	1.49536283724079e-08	-1.09796577928737	0.00345685886529286	mirMAP	-0.134408871088061	5.18539088023815e-06		NA	NA	NA
hsa-miR-21-5p	CCNG1	2.65163477806992	6.72089787690756e-16	-1.09796577928737	0.00345685886529286	miRNAWalker2_validate	-0.224886774894537	0.000346214932289102		NA	NA	NA
hsa-miR-23a-3p	CCNG1	0.925125296618358	0.0127293543936914	-1.09796577928737	0.00345685886529286	MirTarget;miRNATAP	-0.200888127521669	0.000535241935874531		NA	NA	NA
hsa-miR-24-3p	CCNG1	1.55853749533999	0.000524726461381821	-1.09796577928737	0.00345685886529286	miRNAWalker2_validate	-0.168081927718828	0.000383342740156312		NA	NA	NA
hsa-miR-27a-3p	CCNG1	1.76094007417453	0.000216137556256765	-1.09796577928737	0.00345685886529286	MirTarget;miRNATAP	-0.248380855686345	1.48292884762142e-08		NA	NA	NA
hsa-miR-27b-3p	CCNG1	-0.0929089601968123	0.85847352206581	-1.09796577928737	0.00345685886529286	MirTarget;miRNATAP	-0.108145085697662	0.00875389229837119	26623719	Moreover miR-27b directly targets the 3' untranslated regions 3'-UTRs of CCNG1 a well-known negative regulator of P53 stability; Interestingly miR-27b up-regulation leads to increased miR-508-5p expression and this phenomenon is mediated by CCNG1 and P53		gastric cancer
hsa-miR-16-2-3p	CCNG2	3.79845098071094	1.49120139344659e-13	-0.753666435696529	0.104711088978229	mirMAP	-0.130481946222355	0.00818537777088724		NA	NA	NA
hsa-miR-664a-3p	CCNG2	0.249882351950296	0.56171157318348	-0.753666435696529	0.104711088978229	MirTarget;mirMAP	-0.259182171201852	2.38214536562317e-05		NA	NA	NA
hsa-miR-125a-3p	CD82	-0.0748960586927341	0.920735897434087	2.27341221432632	0.000645311124798145	miRanda	-0.153811632530667	0.00238723029376374		NA	NA	NA
hsa-miR-491-5p	CD82	0.569358547192776	0.313310594748302	2.27341221432632	0.000645311124798145	miRanda	-0.248923836263277	0.000275472397101821		NA	NA	NA
hsa-miR-140-5p	CDK2	-0.634610285725923	0.126670572966239	1.42489416332317	1.62801715893662e-05	miRanda	-0.121906717948301	0.00814170704237931		NA	NA	NA
hsa-let-7a-5p	CDK6	0.148081801547773	0.645305441523746	0.50406574702617	0.551236779554206	miRNAWalker2_validate;miRTarBase;TargetScan	-0.645439384156813	2.08585558666525e-05		NA	NA	NA
hsa-let-7b-5p	CDK6	-0.189422992330471	0.651878220048983	0.50406574702617	0.551236779554206	miRNAWalker2_validate;miRTarBase	-0.465531746051444	5.04007910683628e-05		NA	NA	NA
hsa-miR-101-3p	CDK6	-1.12421603598195	0.0200907284788457	0.50406574702617	0.551236779554206	mirMAP	-0.421606618743612	1.93327021487929e-05		NA	NA	NA
hsa-miR-106a-5p	CDK6	3.98693608217557	9.37722470816656e-07	0.50406574702617	0.551236779554206	mirMAP	-0.3914421268643	2.58029820594243e-12		NA	NA	NA
hsa-miR-141-3p	CDK6	7.30474126597325	1.45115996357606e-24	0.50406574702617	0.551236779554206	TargetScan;miRNATAP	-0.20492670051454	0.00089997435535192		NA	NA	NA
hsa-miR-148b-3p	CDK6	1.75622244535669	8.84414356040579e-08	0.50406574702617	0.551236779554206	mirMAP	-0.473118253356064	0.00117507520744895		NA	NA	NA
hsa-miR-200a-3p	CDK6	6.336081120041	4.024313571871e-16	0.50406574702617	0.551236779554206	miRNATAP	-0.351978863285198	6.61784093516688e-10	24009066	microRNA 200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6		liver cancer
hsa-miR-200b-3p	CDK6	5.56167217794639	6.43540045061709e-16	0.50406574702617	0.551236779554206	mirMAP	-0.393674008810918	1.1478210539551e-09		NA	NA	NA
hsa-miR-20b-5p	CDK6	4.5662923200279	4.75238200639144e-05	0.50406574702617	0.551236779554206	mirMAP	-0.284732309778902	2.48291204663733e-12	26166554	The transfection of miR-20b into EJ cells induced G1 phase cell cycle arrest via the decreased expression of cyclin D1 CDK2 and CDK6 without affecting another G1 phase cell cycle regulator cyclin E		bladder cancer
hsa-miR-30a-5p	CDK6	-0.768430903969183	0.320487552854215	0.50406574702617	0.551236779554206	mirMAP	-0.173159552692541	0.0051696250748206		NA	NA	NA
hsa-miR-30d-5p	CDK6	0.302504510257496	0.380193536606962	0.50406574702617	0.551236779554206	mirMAP	-0.498058868266233	0.00043364409008621		NA	NA	NA
hsa-miR-30e-5p	CDK6	0.780047227271616	0.0346714425913016	0.50406574702617	0.551236779554206	mirMAP	-0.536440221801356	4.09131973520604e-05		NA	NA	NA
hsa-miR-34a-5p	CDK6	0.830377770217786	0.0477544831885907	0.50406574702617	0.551236779554206	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.36060880640799	0.00174841793217821	21702042;26104764	Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004	;	bladder cancer;lung cancer
hsa-miR-362-5p	CDK6	-1.22309034685697	0.0452665543907975	0.50406574702617	0.551236779554206	mirMAP	-0.285526744495543	0.000257106653086971		NA	NA	NA
hsa-miR-429	CDK6	6.39965293994036	1.96920201593608e-18	0.50406574702617	0.551236779554206	mirMAP;miRNATAP	-0.252321841763607	3.87842873215362e-05		NA	NA	NA
hsa-miR-497-5p	CDK6	-1.44150596209372	0.0225146607606395	0.50406574702617	0.551236779554206	miRNATAP	-0.311206501941814	3.48572516094014e-05		NA	NA	NA
hsa-miR-502-3p	CDK6	-0.102232623565007	0.80889202592629	0.50406574702617	0.551236779554206	PITA;miRNATAP	-0.416650063741403	0.000268656241814273		NA	NA	NA
hsa-miR-592	CDK6	2.80403350008555	0.0293520213681333	0.50406574702617	0.551236779554206	mirMAP	-0.23124216841781	2.55195577436831e-07		NA	NA	NA
hsa-miR-660-5p	CDK6	-0.0668683798854808	0.885250178390404	0.50406574702617	0.551236779554206	mirMAP	-0.371049523443998	0.000362174896273971		NA	NA	NA
hsa-let-7e-5p	CDKN1A	-0.111012524740586	0.814744515884005	0.575565460455045	0.357582494899873	MirTarget	-0.274146718755294	0.000263797572767074		NA	NA	NA
hsa-let-7g-5p	CDKN1A	0.857251702023746	0.00647597344297273	0.575565460455045	0.357582494899873	MirTarget	-0.31692390865002	0.00585926212615004		NA	NA	NA
hsa-miR-125a-5p	CDKN1A	-1.32352790615388	0.00714301627309467	0.575565460455045	0.357582494899873	miRNAWalker2_validate;miRTarBase	-0.352961178589696	7.16598889800001e-07		NA	NA	NA
hsa-miR-28-5p	CDKN1A	-0.815636722979196	0.0221199948901761	0.575565460455045	0.357582494899873	miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP	-0.54618253223586	3.67357997876153e-08		NA	NA	NA
hsa-miR-30b-3p	CDKN1A	0.169674321578618	0.766080356926625	0.575565460455045	0.357582494899873	MirTarget	-0.164844746301017	0.00864162465933599		NA	NA	NA
hsa-miR-335-5p	CDKN1A	0.167216045757305	0.803897055331049	0.575565460455045	0.357582494899873	miRNAWalker2_validate	-0.250609725261631	1.48353826571499e-06		NA	NA	NA
hsa-miR-345-5p	CDKN1A	2.77314563304336	4.34343702412489e-05	0.575565460455045	0.357582494899873	miRNAWalker2_validate;miRTarBase;MirTarget	-0.226896440422906	9.12582037640469e-06		NA	NA	NA
hsa-miR-423-3p	CDKN1A	1.7128674316395	1.7145324528301e-05	0.575565460455045	0.357582494899873	miRNAWalker2_validate;miRTarBase	-0.268279490593696	0.00252767646001539		NA	NA	NA
hsa-miR-505-5p	CDKN1A	-0.548246528900629	0.331409094367131	0.575565460455045	0.357582494899873	miRNAWalker2_validate;MirTarget	-0.176195799792848	0.00518737322213012		NA	NA	NA
hsa-miR-616-5p	CDKN1A	2.48416313933027	0.00318247475868827	0.575565460455045	0.357582494899873	mirMAP	-0.143849376151027	0.00610419478950803		NA	NA	NA
hsa-miR-96-5p	CDKN1A	5.62521466029286	1.54938806718028e-10	0.575565460455045	0.357582494899873	miRNAWalker2_validate;miRTarBase	-0.170734648939045	0.000337982107370655	26582573	Upregulation of microRNA 96 and its oncogenic functions by targeting CDKN1A in bladder cancer; Bioinformatics prediction combined with luciferase reporter assay were used to verify whether the cyclin-dependent kinase inhibitor CDKN1A was a potential target gene of miR-96; According to the data of miRTarBase CDKN1A might be a candidate target gene of miR-96; In addition luciferase reporter and Western blot assays respectively demonstrated that miR-96 could bind to the putative seed region in CDKN1A mRNA 3'UTR and significantly reduce the expression level of CDKN1A protein; Moreover we found that the inhibition of miR-96 expression remarkably decreased cell proliferation and promoted cell apoptosis of BC cell lines which was consistent with the findings observed following the introduction of CDKN1A cDNA without 3'UTR restored miR-96; Upregulation of miR-96 may contribute to aggressive malignancy partly through suppressing CDKN1A protein expression in BC cells		bladder cancer
hsa-miR-10b-5p	CDKN2A	-3.08172917642729	4.22675074435126e-09	7.38430007921313	1.9263072669935e-15	miRNAWalker2_validate;miRTarBase	-0.3561025709733	0.00054319451875627		NA	NA	NA
hsa-miR-125a-5p	CDKN2A	-1.32352790615388	0.00714301627309467	7.38430007921313	1.9263072669935e-15	miRanda	-0.392381455588874	0.000480466623544498		NA	NA	NA
hsa-miR-106a-5p	FAS	3.98693608217557	9.37722470816656e-07	-0.344841531633832	0.589341195024639	miRNAWalker2_validate;miRTarBase	-0.140227807754695	0.00127753821199214	22431000;27142596	miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway	tumorigenesis;	gastric cancer;gastric cancer
hsa-miR-361-5p	FAS	0.00649167180664723	0.985202350239079	-0.344841531633832	0.589341195024639	miRanda	-0.330419186265804	0.00171930259182594		NA	NA	NA
hsa-miR-590-5p	FAS	1.51400888103768	0.0023888567923017	-0.344841531633832	0.589341195024639	miRanda	-0.19807034795777	0.00636164081342142		NA	NA	NA
hsa-miR-129-5p	GADD45A	-2.66843722411409	0.00695783358331245	-0.566112082294352	0.356860494529648	miRanda	-0.100844116127556	0.00449173907374446		NA	NA	NA
hsa-miR-130b-3p	GADD45A	3.9204771543282	1.2714917955808e-11	-0.566112082294352	0.356860494529648	MirTarget;miRNATAP	-0.171179592036229	0.0032386084520536		NA	NA	NA
hsa-miR-146b-5p	GADD45A	1.87569569182453	0.000737241069698886	-0.566112082294352	0.356860494529648	miRanda	-0.18967214107464	0.00232775278051048		NA	NA	NA
hsa-miR-148b-3p	GADD45A	1.75622244535669	8.84414356040579e-08	-0.566112082294352	0.356860494529648	MirTarget	-0.525743475009119	5.01282872316168e-07		NA	NA	NA
hsa-miR-301a-3p	GADD45A	1.99338115332667	0.000813358604963724	-0.566112082294352	0.356860494529648	MirTarget;miRNATAP	-0.190939096191683	0.000994881284680524		NA	NA	NA
hsa-miR-362-5p	GADD45A	-1.22309034685697	0.0452665543907975	-0.566112082294352	0.356860494529648	MirTarget;PITA;miRNATAP	-0.174083394504546	0.00221778809043954		NA	NA	NA
hsa-miR-375	GADD45A	3.3784490463318	0.0449946294355695	-0.566112082294352	0.356860494529648	miRanda	-0.102232241980599	4.20822114251968e-07		NA	NA	NA
hsa-miR-454-3p	GADD45A	1.40269869979902	0.00366085847011367	-0.566112082294352	0.356860494529648	MirTarget;miRNATAP	-0.309147097462117	1.56973939454024e-05		NA	NA	NA
hsa-miR-500a-5p	GADD45A	0.0170829425378565	0.973960207660626	-0.566112082294352	0.356860494529648	MirTarget;miRNATAP	-0.191557624174549	0.00426069074325481		NA	NA	NA
hsa-miR-500b-5p	GADD45A	0.0167434146432646	0.974498641907253	-0.566112082294352	0.356860494529648	MirTarget	-0.191191795665263	0.0043023159901196		NA	NA	NA
hsa-miR-324-3p	GADD45B	1.51345381556672	0.0038447546677657	-1.882739402569	0.00168698437811886	MirTarget;miRNATAP	-0.17112830558095	0.00882982096915685		NA	NA	NA
hsa-miR-1976	GADD45G	3.27217274919653	3.16337235854532e-12	-3.78199148373951	7.47113859248823e-06	MirTarget	-0.339364756241224	0.000704281453896161		NA	NA	NA
hsa-miR-139-5p	GTSE1	-2.09475477693654	0.000382570602748311	6.12563635615878	1.12877856431801e-32	miRanda	-0.146830780272655	0.00739753317669725		NA	NA	NA
hsa-let-7f-1-3p	IGF1	1.61507869803314	0.00069342464777815	-4.48455379412262	0.00149155200072234	mirMAP	-0.918829913577652	3.87495776454398e-08		NA	NA	NA
hsa-miR-103a-2-5p	IGF1	2.77240253557299	0.000302548514615442	-4.48455379412262	0.00149155200072234	mirMAP	-0.614783124207912	2.47565479190434e-09		NA	NA	NA
hsa-miR-130b-3p	IGF1	3.9204771543282	1.2714917955808e-11	-4.48455379412262	0.00149155200072234	MirTarget	-0.479757958716119	0.000356022414865848		NA	NA	NA
hsa-miR-15b-3p	IGF1	3.57530146629867	5.89922785773482e-11	-4.48455379412262	0.00149155200072234	mirMAP	-0.729097685666816	2.48630408177257e-07		NA	NA	NA
hsa-miR-16-1-3p	IGF1	2.83281226969693	7.54359864580834e-09	-4.48455379412262	0.00149155200072234	mirMAP	-0.814562134768682	3.05533338766364e-07		NA	NA	NA
hsa-miR-19a-3p	IGF1	2.17020503944519	0.00122084653711062	-4.48455379412262	0.00149155200072234	MirTarget	-0.581899015817695	7.91751221290163e-07		NA	NA	NA
hsa-miR-19b-1-5p	IGF1	1.51335451095424	0.0014717605268143	-4.48455379412262	0.00149155200072234	mirMAP	-1.02209573815554	6.70473912999913e-10		NA	NA	NA
hsa-miR-19b-3p	IGF1	1.67581705793313	0.000858910586302716	-4.48455379412262	0.00149155200072234	MirTarget	-0.831868934390103	1.31473916022842e-07		NA	NA	NA
hsa-miR-20a-3p	IGF1	1.9920766549842	0.000624458530894697	-4.48455379412262	0.00149155200072234	mirMAP	-0.765905368079341	1.45024350852968e-08		NA	NA	NA
hsa-miR-27a-3p	IGF1	1.76094007417453	0.000216137556256765	-4.48455379412262	0.00149155200072234	miRNAWalker2_validate;miRTarBase	-1.09876415117095	2.18608056227336e-11		NA	NA	NA
hsa-miR-301a-3p	IGF1	1.99338115332667	0.000813358604963724	-4.48455379412262	0.00149155200072234	MirTarget	-0.46409260853426	0.000552061816042968		NA	NA	NA
hsa-miR-32-3p	IGF1	2.20477794939766	0.0392771274032852	-4.48455379412262	0.00149155200072234	mirMAP	-0.547975732700196	3.20639423670354e-05		NA	NA	NA
hsa-miR-33a-3p	IGF1	2.06269680799532	0.00156436055383943	-4.48455379412262	0.00149155200072234	MirTarget	-0.400091789613134	0.00117684573706475		NA	NA	NA
hsa-miR-452-5p	IGF1	2.45466810475361	0.00114794259949532	-4.48455379412262	0.00149155200072234	MirTarget;mirMAP	-0.28989018336422	0.00626092588038326		NA	NA	NA
hsa-miR-486-5p	IGF1	1.10898145177457	0.309287974401609	-4.48455379412262	0.00149155200072234	PITA;miRNATAP	-0.349556791581636	1.58501267453983e-06		NA	NA	NA
hsa-miR-576-5p	IGF1	1.30320223793746	0.00648929463912994	-4.48455379412262	0.00149155200072234	PITA;mirMAP;miRNATAP	-0.686331142925331	4.29578185739691e-05		NA	NA	NA
hsa-miR-629-5p	IGF1	1.57164125641392	0.0115716388531198	-4.48455379412262	0.00149155200072234	mirMAP	-0.4282336374449	0.000902416424835987		NA	NA	NA
hsa-miR-940	IGF1	3.78496690968119	4.75227557809023e-05	-4.48455379412262	0.00149155200072234	MirTarget;PITA;miRNATAP	-0.340594099196604	0.00112659190128122		NA	NA	NA
hsa-miR-19a-3p	IGFBP3	2.17020503944519	0.00122084653711062	-2.12921819775598	0.0327776531676316	MirTarget;miRNATAP	-0.283452750836352	0.000710551715277028		NA	NA	NA
hsa-miR-19b-3p	IGFBP3	1.67581705793313	0.000858910586302716	-2.12921819775598	0.0327776531676316	MirTarget;miRNATAP	-0.343779035868688	0.00224468336201034		NA	NA	NA
hsa-miR-340-5p	IGFBP3	1.41210478721579	0.00958612942879818	-2.12921819775598	0.0327776531676316	MirTarget	-0.403426206170816	9.88624132059415e-05		NA	NA	NA
hsa-miR-140-5p	MDM2	-0.634610285725923	0.126670572966239	1.10063403547143	0.00277879157924784	miRanda	-0.133991561849076	0.00853809577209546		NA	NA	NA
hsa-miR-26b-5p	MDM2	0.314414148564179	0.461628303578321	1.10063403547143	0.00277879157924784	miRNAWalker2_validate	-0.167905763917418	0.00067658693094048		NA	NA	NA
hsa-miR-374b-5p	MDM2	-0.114749866169918	0.764888930049438	1.10063403547143	0.00277879157924784	mirMAP	-0.202257195528026	0.000245802806142865		NA	NA	NA
hsa-miR-450a-5p	MDM2	0.279271977544647	0.642367882565951	1.10063403547143	0.00277879157924784	mirMAP	-0.105188175118483	0.00254474898275964		NA	NA	NA
hsa-miR-151a-3p	MDM4	0.373902859770645	0.376924505912903	0.0211961799945204	0.95100073912392	mirMAP	-0.15452478141404	0.000865177043776833		NA	NA	NA
hsa-miR-152-3p	MDM4	0.0996927696128376	0.867443498706607	0.0211961799945204	0.95100073912392	MirTarget	-0.131159996894991	5.30707674661402e-05		NA	NA	NA
hsa-miR-15b-3p	MDM4	3.57530146629867	5.89922785773482e-11	0.0211961799945204	0.95100073912392	mirMAP	-0.16053518422057	2.65460975112255e-06		NA	NA	NA
hsa-miR-21-3p	MDM4	3.50297439576639	6.39946844099206e-10	0.0211961799945204	0.95100073912392	MirTarget	-0.173114587075356	1.41406030577636e-07		NA	NA	NA
hsa-miR-222-5p	MDM4	2.52056758362407	0.00142010793166944	0.0211961799945204	0.95100073912392	mirMAP	-0.114591872103688	2.10617140780707e-06		NA	NA	NA
hsa-miR-27a-3p	MDM4	1.76094007417453	0.000216137556256765	0.0211961799945204	0.95100073912392	miRNATAP	-0.217417942492543	5.6844747025318e-08		NA	NA	NA
hsa-miR-374b-5p	MDM4	-0.114749866169918	0.764888930049438	0.0211961799945204	0.95100073912392	mirMAP	-0.15913973431597	0.0019845968099368		NA	NA	NA
hsa-miR-3922-3p	MDM4	2.5745007343008	8.26367348669111e-05	0.0211961799945204	0.95100073912392	mirMAP	-0.108122228808751	0.000326205455999305		NA	NA	NA
hsa-miR-125a-3p	PERP	-0.0748960586927341	0.920735897434087	3.35654913708773	3.59170305264024e-05	miRanda	-0.300271931293592	9.65450107993077e-07		NA	NA	NA
hsa-miR-129-5p	PERP	-2.66843722411409	0.00695783358331245	3.35654913708773	3.59170305264024e-05	miRanda	-0.159991823063076	0.000746530094633219		NA	NA	NA
hsa-miR-192-5p	PERP	1.77716187978541	0.113485496183047	3.35654913708773	3.59170305264024e-05	miRNAWalker2_validate	-0.328141854181137	7.66601940503303e-17		NA	NA	NA
hsa-miR-215-5p	PERP	3.66990923176752	0.00294614570694381	3.35654913708773	3.59170305264024e-05	miRNAWalker2_validate	-0.201456460692132	4.41637558047999e-08		NA	NA	NA
hsa-miR-218-5p	PERP	-1.62589026509455	0.0400573414088521	3.35654913708773	3.59170305264024e-05	MirTarget	-0.431646871321141	1.87330562323677e-14		NA	NA	NA
hsa-miR-582-5p	PERP	0.685177900016753	0.447761540297692	3.35654913708773	3.59170305264024e-05	miRNATAP	-0.159900690737452	0.00191093201166242		NA	NA	NA
hsa-miR-616-5p	PERP	2.48416313933027	0.00318247475868827	3.35654913708773	3.59170305264024e-05	MirTarget	-0.234453356909529	0.00065851311561296		NA	NA	NA
hsa-miR-660-5p	PERP	-0.0668683798854808	0.885250178390404	3.35654913708773	3.59170305264024e-05	MirTarget	-0.349950680529466	0.000553080832041582		NA	NA	NA
hsa-miR-186-5p	PMAIP1	0.445443449112564	0.185447310527704	3.32881522096224	3.64051817309727e-07	miRNAWalker2_validate;mirMAP	-0.320120218991979	0.00536366054179603		NA	NA	NA
hsa-miR-375	PMAIP1	3.3784490463318	0.0449946294355695	3.32881522096224	3.64051817309727e-07	miRanda	-0.106186150544681	1.39778282888153e-06		NA	NA	NA
hsa-let-7a-3p	PPM1D	0.82512001802525	0.0468122405194487	-0.273974615296041	0.428225611706864	MirTarget	-0.162834175579683	0.000580187168925545		NA	NA	NA
hsa-let-7f-1-3p	PPM1D	1.61507869803314	0.00069342464777815	-0.273974615296041	0.428225611706864	MirTarget	-0.107811319934411	0.00884850326619756		NA	NA	NA
hsa-miR-26b-5p	PPM1D	0.314414148564179	0.461628303578321	-0.273974615296041	0.428225611706864	miRNAWalker2_validate	-0.146612907299171	0.00148436864094975		NA	NA	NA
hsa-miR-29a-3p	PPM1D	-0.638239697975974	0.251923581881716	-0.273974615296041	0.428225611706864	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.190017340123395	3.71430044841313e-08		NA	NA	NA
hsa-miR-29a-5p	PPM1D	0.0748295222568571	0.884125894063293	-0.273974615296041	0.428225611706864	MirTarget	-0.223788427778379	2.18552553092569e-09		NA	NA	NA
hsa-miR-29b-3p	PPM1D	0.666547117072858	0.234055379278093	-0.273974615296041	0.428225611706864	MirTarget;miRNATAP	-0.196588951740827	9.53657739934713e-09		NA	NA	NA
hsa-miR-590-3p	PPM1D	2.35429565068338	2.79601879608564e-06	-0.273974615296041	0.428225611706864	MirTarget;PITA;miRanda;mirMAP	-0.17896805288214	2.43849835975909e-06		NA	NA	NA
hsa-miR-590-5p	PPM1D	1.51400888103768	0.0023888567923017	-0.273974615296041	0.428225611706864	miRanda	-0.126166609418658	0.00123445474325268		NA	NA	NA
hsa-miR-106a-5p	PTEN	3.98693608217557	9.37722470816656e-07	-0.848820542036926	0.0698463061072717	miRNATAP	-0.121150170909335	0.000141310345865052	26097565;26318586	miR 106a promotes growth and metastasis of non small cell lung cancer by targeting PTEN; Furthermore the presence of miR-106a was inversely correlated with PTEN in NSCLC tissues; Overall this study suggested that miR-106a inhibited the growth and metastasis of NSCLC cells by decreasing PTEN expression;Further pterostilbene through downregulation of miR-17-5p and miR-106a-5p expression both in tumors and systemic circulation rescued PTEN mRNA and protein levels leading to reduced tumor growth in vivo	metastasis;	lung squamous cell cancer;prostate cancer
hsa-miR-130b-3p	PTEN	3.9204771543282	1.2714917955808e-11	-0.848820542036926	0.0698463061072717	MirTarget;miRNATAP	-0.139961927957452	0.00157623535045685	26837847;25637514	The miR 130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN; In clinical bladder cancer specimens downregulation of PTEN was found to be closely correlated with miR-130 family expression levels;MiR 130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells; We confirmed that miR-130b interacted with the 3'-untranslated region of PTEN and that an increase in the expression level of miR-130b negatively affected the protein level of PTEN; However the dysregulation of miR-130b had no obvious impact on PTEN mRNA; As Akt is a downstream effector of PTEN we explored if miR-130b affected Akt expression and found that miR-130b indirectly regulated the level of phosphorylated Akt while total Akt protein remained unchanged; The results indicate that miR-130b plays an oncogenic role in ESCC cells by repressing PTEN expression and Akt phosphorylation which would be helpful in developing miRNA-based treatments for ESCC	cell migration;	bladder cancer;esophageal cancer
hsa-miR-182-5p	PTEN	5.86988712704738	1.22411588571584e-15	-0.848820542036926	0.0698463061072717	mirMAP	-0.100967623222909	0.00331619412338393		NA	NA	NA
hsa-miR-188-5p	PTEN	1.39111178824125	0.0251592818948912	-0.848820542036926	0.0698463061072717	MirTarget;PITA;miRNATAP	-0.123015522557534	0.0041039297017108		NA	NA	NA
hsa-miR-200b-3p	PTEN	5.56167217794639	6.43540045061709e-16	-0.848820542036926	0.0698463061072717	TargetScan;mirMAP	-0.111724552597797	0.00227683849654151	22637745;21408027	Re expression of miR 200 by novel approaches regulates the expression of PTEN and MT1 MMP in pancreatic cancer; We initially compared the expression profile of miR-200 family PTEN and MT1-MMP expression in six pancreatic cancer PC cell lines by qRT-PCR and western blot analysis; The expression of miR-200 family and PTEN was significantly re-expressed whereas the expression of MT1-MMP was down-regulated by CDF and BR-DIM treatment; These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment;Anti tumor activity of a novel compound CDF is mediated by regulating miR 21 miR 200 and PTEN in pancreatic cancer; In a xenograft mouse model of human PC CDF treatment significantly inhibited tumor growth which was associated with decreased NF-κB DNA binding activity COX-2 and miR-21 expression and increased PTEN and miR-200 expression in tumor remnants	;	pancreatic cancer;pancreatic cancer
hsa-miR-25-3p	PTEN	1.12623030168869	0.00311079344417173	-0.848820542036926	0.0698463061072717	miRTarBase;MirTarget;miRNATAP	-0.346634698468156	5.85013644059584e-07		NA	NA	NA
hsa-miR-28-5p	PTEN	-0.815636722979196	0.0221199948901761	-0.848820542036926	0.0698463061072717	miRanda	-0.201833894647843	0.00766209794137583		NA	NA	NA
hsa-miR-32-3p	PTEN	2.20477794939766	0.0392771274032852	-0.848820542036926	0.0698463061072717	mirMAP	-0.128718962710161	0.00318430811052814	24123284;25647261;23617834	In this study we determined the levels of the correlation between and the clinical significance of the expression of miR-32 and phosphatase and tensin homologue PTEN a tumor suppressor targeted by miR-32 in CRC; The levels of miR-32 and PTEN gene expression in 35 colorectal carcinoma samples 35 corresponding cancer-adjacent tissue samples 27 colorectal adenoma samples and 16 normal tissue samples were quantified using real-time quantitative reverse transcriptase-polymerase chain reaction; The relationship between the miR-32 and PTEN protein expression and clinicopathological factors was analyzed; Significant upregulation of miR-32 expression and reduction of PTEN were identified in CRC tissues; An inverse relationship between miR-32 and PTEN protein expression was identified; MiR-32 and PTEN expression were inversely correlated and miR-32 may be associated with the development of CRC;MiR 32 induces cell proliferation migration and invasion in hepatocellular carcinoma by targeting PTEN; Besides miRNA-32 down-regulates PTEN through binding to 3'-UTR of PTEN mRNA from luciferase reporter assay and the expression level of miR-32 could affect the proliferation migration and invasion of liver cancer cell lines via PTEN/Akt signaling pathway; Down-expression of PTEN could significantly attenuate the inhibitory effects of knockdown miR-32 on the proliferation migration and invasion of liver cancer cells suggesting that miR-32 could be a potential target for HCC treatment;MicroRNA 32 miR 32 regulates phosphatase and tensin homologue PTEN expression and promotes growth migration and invasion in colorectal carcinoma cells; In this study we identified the potential effects of miR-32 on some important biological properties of CRC cells and clarified the regulation of PTEN by miR-32; The 3'-untranslated region 3'-UTR of PTEN combined with miR-32 was verified by dual-luciferase reporter assay; Gain-of-function and loss-of-function studies showed that overexpression of miR-32 promoted SW480 cell proliferation migration and invasion reduced apoptosis and resulted in downregulation of PTEN at a posttranscriptional level; However miR-32 knock-down inhibited these processes in HCT-116 cells and enhanced the expression of PTEN protein; In addition we further identified PTEN as the functional downstream target of miR-32 by directly targeting the 3'-UTR of PTEN; Our results demonstrated that miR-32 was involved in tumorigenesis of CRC at least in part by suppression of PTEN	;;tumorigenesis	colorectal cancer;liver cancer;colorectal cancer
hsa-miR-374b-5p	PTEN	-0.114749866169918	0.764888930049438	-0.848820542036926	0.0698463061072717	MirTarget;mirMAP;miRNATAP	-0.184462823771875	0.00876765791811961		NA	NA	NA
hsa-miR-421	PTEN	1.97624148591545	0.000915838012451138	-0.848820542036926	0.0698463061072717	miRanda	-0.135924707077455	0.00219014673757631		NA	NA	NA
hsa-miR-532-5p	PTEN	-0.297424983759107	0.503934707453099	-0.848820542036926	0.0698463061072717	PITA;mirMAP;miRNATAP	-0.208656603286142	0.000512381739154765		NA	NA	NA
hsa-miR-590-3p	PTEN	2.35429565068338	2.79601879608564e-06	-0.848820542036926	0.0698463061072717	MirTarget;PITA;miRanda;mirMAP	-0.140657129239091	0.00714320619469358	23803188	Targetscan predicted PDCD4 and PTEN as the potential target genes of miR-590-5p and miR-590-3p which was verified by luciferase reporter system and Western blotting; miR-590-3p was found to activate PI3K-AKT signaling pathway by down-regulating PTEN to promote AKT1-S473 phosphorylation		liver cancer
hsa-miR-7-1-3p	PTEN	1.43074343339835	0.00471215970502094	-0.848820542036926	0.0698463061072717	mirMAP	-0.176200102858594	0.000755349982671746		NA	NA	NA
hsa-miR-744-3p	PTEN	1.08385719878174	0.131243679775541	-0.848820542036926	0.0698463061072717	miRNATAP	-0.108079947024833	0.0033964072740039		NA	NA	NA
hsa-miR-93-5p	PTEN	2.65964181833033	2.58315947526774e-08	-0.848820542036926	0.0698463061072717	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.180023874518816	0.000957550001063743	25633810;26243299;22465665;26087719	MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC;microRNA 93 promotes cell proliferation via targeting of PTEN in Osteosarcoma cells; An miRNA miR-93 was significantly up-regulated whereas phosphatase and tensin homologue PTEN expression was significantly down-regulated in all tested OS cells when compared with hMSCs; Ectopic expression of miR-93 decreased PTEN protein levels; Taking these observations together miR-93 can be seen to play a critical role in carcinogenesis through suppression of PTEN and may serve as a therapeutic target for the treatment of OS;Furthermore we found that miR-93 can directly target PTEN and participates in the regulation of the AKT signaling pathway; MiR-93 inversely correlates with PTEN expression in CDDP-resistant and sensitive human ovarian cancer tissues;Furthermore our study found berberine could inhibit miR-93 expression and function in ovarian cancer as shown by an increase of its target PTEN an important tumor suppressor in ovarian cancer; More importantly A2780 cells that were treated with PTEN siRNA had a survival pattern that is similar to cells with miR-93 overexpression	;tumorigenesis;;poor survival	liver cancer;sarcoma;ovarian cancer;ovarian cancer
hsa-miR-100-5p	RRM2	-2.83165290318755	0.000582447392959329	6.93739023853395	1.46868376790475e-45	miRNAWalker2_validate	-0.20264316265192	1.15513920852732e-07		NA	NA	NA
hsa-miR-125a-5p	RRM2	-1.32352790615388	0.00714301627309467	6.93739023853395	1.46868376790475e-45	miRanda	-0.215173623198749	0.00105001170604655		NA	NA	NA
hsa-miR-199a-5p	RRM2	-1.24888110793613	0.0747755616523728	6.93739023853395	1.46868376790475e-45	miRanda	-0.125091098767056	0.00661567591531651		NA	NA	NA
hsa-miR-30a-5p	RRM2	-0.768430903969183	0.320487552854215	6.93739023853395	1.46868376790475e-45	miRNAWalker2_validate	-0.159770146314814	0.000118836879137295		NA	NA	NA
hsa-miR-26a-2-3p	RRM2B	0.348140795080704	0.50914395378277	0.137194667272666	0.724468977773045	mirMAP	-0.173719575196303	3.04299090608753e-05		NA	NA	NA
hsa-miR-362-3p	RRM2B	0.679952485897744	0.226148468488576	0.137194667272666	0.724468977773045	miRanda	-0.130131355593235	0.000924581778152184		NA	NA	NA
hsa-miR-7-1-3p	RRM2B	1.43074343339835	0.00471215970502094	0.137194667272666	0.724468977773045	mirMAP	-0.150522527703441	0.00050556847365043		NA	NA	NA
hsa-miR-129-5p	SERPINB5	-2.66843722411409	0.00695783358331245	6.87182501219636	2.07410828722968e-05	miRanda	-0.334097341153656	0.000399245171368704		NA	NA	NA
hsa-miR-186-5p	SERPINB5	0.445443449112564	0.185447310527704	6.87182501219636	2.07410828722968e-05	mirMAP	-1.07534113206663	0.000127315313230776		NA	NA	NA
hsa-miR-30a-5p	SERPINB5	-0.768430903969183	0.320487552854215	6.87182501219636	2.07410828722968e-05	miRNAWalker2_validate	-0.718002333826778	8.78853781362534e-10		NA	NA	NA
hsa-miR-335-5p	SERPINB5	0.167216045757305	0.803897055331049	6.87182501219636	2.07410828722968e-05	miRNAWalker2_validate	-0.704929160976713	2.19309938256609e-07		NA	NA	NA
hsa-miR-338-3p	SERPINB5	0.447551118940466	0.558485097370031	6.87182501219636	2.07410828722968e-05	miRanda	-0.38503482870769	0.00148472854052524		NA	NA	NA
hsa-miR-589-3p	SERPINB5	1.33205316880069	0.052632683806148	6.87182501219636	2.07410828722968e-05	MirTarget	-0.413499756489981	0.00229624401836997		NA	NA	NA
hsa-miR-30c-5p	SERPINE1	0.38723991118075	0.348605235643473	0.617692230647947	0.572474588134307	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.430478549390397	0.00464929561193146		NA	NA	NA
hsa-miR-30d-5p	SERPINE1	0.302504510257496	0.380193536606962	0.617692230647947	0.572474588134307	miRNATAP	-0.571023174230567	0.00187005473771538		NA	NA	NA
hsa-miR-34a-5p	SERPINE1	0.830377770217786	0.0477544831885907	0.617692230647947	0.572474588134307	miRNATAP	-0.454822685947182	0.00229694402077437		NA	NA	NA
hsa-miR-378a-5p	SERPINE1	1.25775140086104	0.0500877723587615	0.617692230647947	0.572474588134307	MirTarget	-0.403730798540002	2.50727400864339e-05		NA	NA	NA
hsa-miR-99a-5p	SERPINE1	-2.72139054000803	0.00621971944534118	0.617692230647947	0.572474588134307	miRNAWalker2_validate	-0.208155381578803	0.000740541769690584		NA	NA	NA
hsa-miR-15b-5p	SESN1	3.32329949959268	8.40210501034588e-13	-1.78011230018704	6.12493041347409e-05	MirTarget;miRNATAP	-0.216447875967851	3.9110601969145e-05		NA	NA	NA
hsa-miR-16-5p	SESN1	2.93575808220754	2.15436817162977e-10	-1.78011230018704	6.12493041347409e-05	MirTarget;miRNATAP	-0.167026776448019	0.00185428852817214		NA	NA	NA
hsa-miR-200b-3p	SESN1	5.56167217794639	6.43540045061709e-16	-1.78011230018704	6.12493041347409e-05	MirTarget;TargetScan	-0.146688825292763	2.55312975446406e-05		NA	NA	NA
hsa-miR-200c-3p	SESN1	6.47012025883743	2.64500707716408e-26	-1.78011230018704	6.12493041347409e-05	MirTarget;miRNATAP	-0.112372276298621	0.00331320290805762	24791940	We found that miR-200c overexpression increased cellular radiosensitivity by direct regulation of the oxidative stress response genes PRDX2 GAPB/Nrf2 and SESN1 in ways that inhibits DNA double-strand breaks repair increase levels of reactive oxygen species and upregulate p21	drug resistance	lung cancer
hsa-miR-3065-3p	SESN1	1.89496019576082	0.0308154823923145	-1.78011230018704	6.12493041347409e-05	MirTarget;miRNATAP	-0.124737950167474	1.26831488726061e-05		NA	NA	NA
hsa-miR-429	SESN1	6.39965293994036	1.96920201593608e-18	-1.78011230018704	6.12493041347409e-05	MirTarget;PITA;miRanda;miRNATAP	-0.140903476022347	1.43696121848609e-05		NA	NA	NA
hsa-miR-106a-5p	SESN2	3.98693608217557	9.37722470816656e-07	0.0848557489527044	0.847826126812115	miRNATAP	-0.124013000648077	3.37583939525419e-05		NA	NA	NA
hsa-miR-30d-3p	SESN2	-0.0740421896025512	0.857423650167556	0.0848557489527044	0.847826126812115	mirMAP	-0.227148393895071	0.000204499733994002		NA	NA	NA
hsa-miR-628-5p	SESN2	1.04832355434705	0.0252368809675445	0.0848557489527044	0.847826126812115	mirMAP	-0.171837473156692	0.00134684728756802		NA	NA	NA
hsa-miR-106a-5p	SESN3	3.98693608217557	9.37722470816656e-07	-0.383534957105207	0.69604184723725	MirTarget	-0.275453105909155	3.53245426120999e-05		NA	NA	NA
hsa-miR-192-3p	SESN3	0.84572845432662	0.480940346018965	-0.383534957105207	0.69604184723725	MirTarget	-0.245730463880128	1.22100582290478e-07		NA	NA	NA
hsa-miR-200b-3p	SESN3	5.56167217794639	6.43540045061709e-16	-0.383534957105207	0.69604184723725	MirTarget;TargetScan	-0.203159343193917	0.00825031783212325		NA	NA	NA
hsa-miR-200c-3p	SESN3	6.47012025883743	2.64500707716408e-26	-0.383534957105207	0.69604184723725	MirTarget	-0.222251723022918	0.00801686722592441		NA	NA	NA
hsa-miR-20b-5p	SESN3	4.5662923200279	4.75238200639144e-05	-0.383534957105207	0.69604184723725	MirTarget	-0.196330699719796	5.04491333395314e-05		NA	NA	NA
hsa-miR-30a-3p	SESN3	-1.22212086897848	0.167565797592104	-0.383534957105207	0.69604184723725	mirMAP	-0.239560457640291	0.000120517231561889		NA	NA	NA
hsa-miR-338-5p	SESN3	-0.108304629897487	0.894675560494607	-0.383534957105207	0.69604184723725	mirMAP	-0.297132519082299	1.13208467145872e-05		NA	NA	NA
hsa-miR-363-3p	SESN3	4.27232887548977	8.53979362839458e-06	-0.383534957105207	0.69604184723725	MirTarget	-0.227574464957543	5.90183133029872e-05		NA	NA	NA
hsa-miR-454-3p	SESN3	1.40269869979902	0.00366085847011367	-0.383534957105207	0.69604184723725	mirMAP	-0.30154487456461	0.00905944117231056		NA	NA	NA
hsa-miR-582-5p	SESN3	0.685177900016753	0.447761540297692	-0.383534957105207	0.69604184723725	MirTarget	-0.24867294867862	4.69929451808185e-05		NA	NA	NA
hsa-miR-616-5p	SESN3	2.48416313933027	0.00318247475868827	-0.383534957105207	0.69604184723725	mirMAP	-0.234855006190514	0.00433029734126226		NA	NA	NA
hsa-miR-625-5p	SESN3	2.02792641909347	0.000935142379948297	-0.383534957105207	0.69604184723725	MirTarget	-0.237793804822792	0.00904425844540546		NA	NA	NA
hsa-miR-92b-3p	SESN3	1.69303761469782	0.0103484911955574	-0.383534957105207	0.69604184723725	MirTarget;miRNATAP	-0.338007828366073	5.05883016847834e-05		NA	NA	NA
hsa-miR-96-5p	SESN3	5.62521466029286	1.54938806718028e-10	-0.383534957105207	0.69604184723725	MirTarget;TargetScan	-0.196026302218978	0.00909632236749779		NA	NA	NA
hsa-miR-532-3p	SFN	0.643755490841218	0.214842585969913	8.01375902962281	1.40931878071373e-13	miRNATAP	-0.433062948911213	0.000470253719105129		NA	NA	NA
hsa-miR-1296-5p	SHISA5	-0.598201496856316	0.389976345899309	0.0659135154171242	0.87592469383952	miRNAWalker2_validate	-0.162681163964937	1.56561888784616e-06		NA	NA	NA
hsa-let-7a-5p	THBS1	0.148081801547773	0.645305441523746	-3.75129916683394	0.000103499881096753	miRNAWalker2_validate;TargetScan	-0.497243904586914	0.00492292853577542		NA	NA	NA
hsa-miR-16-1-3p	THBS1	2.83281226969693	7.54359864580834e-09	-3.75129916683394	0.000103499881096753	MirTarget	-0.643028399066049	3.09438933664662e-09		NA	NA	NA
hsa-miR-17-5p	THBS1	2.3269271449522	2.13987445663942e-05	-3.75129916683394	0.000103499881096753	miRNAWalker2_validate	-0.267945077391595	0.00757970547802144		NA	NA	NA
hsa-miR-182-5p	THBS1	5.86988712704738	1.22411588571584e-15	-3.75129916683394	0.000103499881096753	MirTarget	-0.241099584124763	0.000765040193303936	24053448	Effects of anti miR 182 on TSP 1 expression in human colon cancer cells: there is a sense in antisense?; We investigate on the molecular mechanism by which miR-182 could regulate thrombospondin-1 TSP-1 expression a protein downregulated in CRC and inversely correlated with tumor vascularity and metastasis; miR-182 over-expressed in colorectal cancer CRC has like predictive target thrombospondin-1 TSP-1 a protein inversely correlated with tumor vascularity and metastasis that results downregulated in different types of cancer including CRC; We found that TSP-1 increased after transfection with anti-miR-182 and we showed that miR-182 targets TSP-1 3'UTR-mRNA in both cells; Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells	metastasis	colon cancer
hsa-miR-186-5p	THBS1	0.445443449112564	0.185447310527704	-3.75129916683394	0.000103499881096753	mirMAP	-0.462978112860335	0.00599316633809753		NA	NA	NA
hsa-miR-19b-3p	THBS1	1.67581705793313	0.000858910586302716	-3.75129916683394	0.000103499881096753	MirTarget;mirMAP	-0.333448340944079	0.00241856130914615		NA	NA	NA
hsa-miR-200a-5p	THBS1	6.52092140839401	5.73108242597059e-22	-3.75129916683394	0.000103499881096753	MirTarget	-0.485719624657622	5.54901388898712e-11		NA	NA	NA
hsa-miR-200b-5p	THBS1	6.81954246537908	6.31100593281326e-24	-3.75129916683394	0.000103499881096753	MirTarget	-0.501001329221048	9.13787343375865e-12		NA	NA	NA
hsa-miR-20a-5p	THBS1	2.13553469875764	0.000181201072324354	-3.75129916683394	0.000103499881096753	miRNAWalker2_validate	-0.307672252327679	0.00140150807491854		NA	NA	NA
hsa-miR-3065-5p	THBS1	2.14185373842821	0.0609400502269891	-3.75129916683394	0.000103499881096753	MirTarget	-0.227705987060518	0.000143233633612563		NA	NA	NA
hsa-miR-33a-3p	THBS1	2.06269680799532	0.00156436055383943	-3.75129916683394	0.000103499881096753	MirTarget;mirMAP	-0.24999380439174	0.00320886077009575		NA	NA	NA
hsa-miR-375	THBS1	3.3784490463318	0.0449946294355695	-3.75129916683394	0.000103499881096753	miRanda	-0.104064726462059	0.00140403889155616		NA	NA	NA
hsa-miR-500a-5p	THBS1	0.0170829425378565	0.973960207660626	-3.75129916683394	0.000103499881096753	mirMAP	-0.360122797705364	0.000716954259923395		NA	NA	NA
hsa-miR-576-5p	THBS1	1.30320223793746	0.00648929463912994	-3.75129916683394	0.000103499881096753	mirMAP	-0.371752416748424	0.00133090246897115		NA	NA	NA
hsa-miR-590-3p	THBS1	2.35429565068338	2.79601879608564e-06	-3.75129916683394	0.000103499881096753	miRanda	-0.305195275125083	0.00517237635189344		NA	NA	NA
hsa-miR-616-5p	THBS1	2.48416313933027	0.00318247475868827	-3.75129916683394	0.000103499881096753	mirMAP	-0.253411231221945	0.00197529844240196		NA	NA	NA
hsa-miR-340-5p	TNFRSF10B	1.41210478721579	0.00958612942879818	1.49454504792051	0.00242678998916782	miRNAWalker2_validate	-0.149759402379779	0.00368309518497458		NA	NA	NA
hsa-miR-192-5p	TP73	1.77716187978541	0.113485496183047	6.73461147555657	6.31501771558468e-15	mirMAP	-0.125949998024971	0.00567396966274381		NA	NA	NA
hsa-miR-335-5p	TP73	0.167216045757305	0.803897055331049	6.73461147555657	6.31501771558468e-15	mirMAP	-0.293450631584882	0.000112060876458774		NA	NA	NA
hsa-let-7a-3p	ZMAT3	0.82512001802525	0.0468122405194487	-0.0572615713923394	0.923643721266638	mirMAP	-0.256953120813624	0.00176563549820169		NA	NA	NA
hsa-miR-106b-5p	ZMAT3	2.80565545918114	1.14547999022566e-09	-0.0572615713923394	0.923643721266638	mirMAP	-0.231862038028038	0.00122840610622987		NA	NA	NA
hsa-miR-130a-3p	ZMAT3	0.176861046122832	0.7577473016872	-0.0572615713923394	0.923643721266638	MirTarget	-0.173523896090925	0.00337235787378416		NA	NA	NA
hsa-miR-148b-3p	ZMAT3	1.75622244535669	8.84414356040579e-08	-0.0572615713923394	0.923643721266638	MirTarget	-0.357156077776534	0.000507254194453582		NA	NA	NA
hsa-miR-148b-5p	ZMAT3	2.80812018666078	3.97536665756679e-08	-0.0572615713923394	0.923643721266638	MirTarget	-0.195799071602786	0.0025997180055881		NA	NA	NA
hsa-miR-17-5p	ZMAT3	2.3269271449522	2.13987445663942e-05	-0.0572615713923394	0.923643721266638	mirMAP	-0.161523800430286	0.00833690808469695		NA	NA	NA
hsa-miR-186-5p	ZMAT3	0.445443449112564	0.185447310527704	-0.0572615713923394	0.923643721266638	MirTarget	-0.350773049299207	0.000616046562466636		NA	NA	NA
hsa-miR-18a-3p	ZMAT3	3.64944956993027	7.20156641833731e-07	-0.0572615713923394	0.923643721266638	MirTarget	-0.196004043322084	1.28204554340561e-05		NA	NA	NA
hsa-miR-193a-3p	ZMAT3	0.646392169474854	0.207134343676122	-0.0572615713923394	0.923643721266638	MirTarget	-0.208083720363449	0.00168501622454533		NA	NA	NA
hsa-miR-19b-3p	ZMAT3	1.67581705793313	0.000858910586302716	-0.0572615713923394	0.923643721266638	MirTarget	-0.182913995987664	0.0064598572633468		NA	NA	NA
hsa-miR-301a-3p	ZMAT3	1.99338115332667	0.000813358604963724	-0.0572615713923394	0.923643721266638	MirTarget	-0.171223906755996	0.00241025606440236		NA	NA	NA
hsa-miR-32-3p	ZMAT3	2.20477794939766	0.0392771274032852	-0.0572615713923394	0.923643721266638	mirMAP	-0.196860227125231	0.000383202877017517		NA	NA	NA
hsa-miR-320a	ZMAT3	-0.912036444869976	0.0565555443926988	-0.0572615713923394	0.923643721266638	miRanda;mirMAP	-0.205985864533417	0.00375001170086824		NA	NA	NA
hsa-miR-320b	ZMAT3	0.20205459771295	0.727216419960509	-0.0572615713923394	0.923643721266638	miRanda;mirMAP	-0.23487366853554	5.47638644596143e-05		NA	NA	NA
hsa-miR-550a-3p	ZMAT3	2.59872127213466	0.00155498164206068	-0.0572615713923394	0.923643721266638	mirMAP	-0.130828741829995	0.00919809955825291		NA	NA	NA
hsa-miR-576-5p	ZMAT3	1.30320223793746	0.00648929463912994	-0.0572615713923394	0.923643721266638	MirTarget	-0.2445189456287	0.000530711427337346		NA	NA	NA
hsa-miR-590-3p	ZMAT3	2.35429565068338	2.79601879608564e-06	-0.0572615713923394	0.923643721266638	mirMAP;miRNATAP	-0.290894864408274	1.03497567545109e-05		NA	NA	NA
hsa-miR-590-5p	ZMAT3	1.51400888103768	0.0023888567923017	-0.0572615713923394	0.923643721266638	miRanda	-0.21545980599192	0.00146162362627182		NA	NA	NA
hsa-miR-671-5p	ZMAT3	1.48527046124636	0.00686722328347111	-0.0572615713923394	0.923643721266638	MirTarget	-0.202596246035415	0.000958646655088844		NA	NA	NA
hsa-miR-7-1-3p	ZMAT3	1.43074343339835	0.00471215970502094	-0.0572615713923394	0.923643721266638	mirMAP	-0.269336476064865	4.94737990581124e-05		NA	NA	NA
hsa-miR-940	ZMAT3	3.78496690968119	4.75227557809023e-05	-0.0572615713923394	0.923643721266638	MirTarget;miRNATAP	-0.146480736021824	0.000825615637951938		NA	NA	NA
hsa-miR-942-5p	ZMAT3	3.36242661558642	1.89848306955335e-10	-0.0572615713923394	0.923643721266638	MirTarget	-0.193332887356596	0.00190675130635024		NA	NA	NA