miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-3p APC 0.0966652362351867 0.423761916840503 -0.546284851471097 3.40552793858261e-06 mirMAP -0.184630001240554 1.60274842027997e-05 NA NA NA hsa-miR-125a-5p APC 0.215366061934933 0.119550904549401 -0.546284851471097 3.40552793858261e-06 miRanda -0.241642305543728 5.41842025946961e-11 NA NA NA hsa-miR-135b-5p APC 1.5570143078477 4.60753610971455e-13 -0.546284851471097 3.40552793858261e-06 miRTarBase;MirTarget -0.101442831003325 1.35019474063077e-05 24735923;18632633;23328512 We show that miR-135b overexpression is triggered in mice and humans by APC loss PTEN/PI3K pathway deregulation and SRC overexpression and promotes tumor transformation and progression;Regulation of the adenomatous polyposis coli gene by the miR 135 family in colorectal cancer;Real-time quantitative PCR and Western blot were used to explore the relationship between miR-135b and adenomatous polyposis coli APC; MiR-135b promoted gastric cancer cell proliferation inhibited its apoptosis and directly regulated the expression of APC in gastric cancer cell progression;; colon cancer;colorectal cancer;gastric cancer hsa-miR-182-5p APC 1.15060905311096 6.25565852529946e-10 -0.546284851471097 3.40552793858261e-06 MirTarget -0.105150505355621 0.000111476597787192 NA NA NA hsa-miR-186-5p APC 0.353452958261612 0.000145058448579496 -0.546284851471097 3.40552793858261e-06 miRNAWalker2_validate -0.292964288394194 1.18140584181448e-07 NA NA NA hsa-miR-193a-3p APC 0.22120710726779 0.111827069464729 -0.546284851471097 3.40552793858261e-06 miRanda -0.160350465730158 1.51155317135791e-05 NA NA NA hsa-miR-21-5p APC 1.62465922021121 3.44191300985109e-58 -0.546284851471097 3.40552793858261e-06 miRNAWalker2_validate -0.278906111202813 6.58270059300518e-10 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-miR-320a APC 0.801356001806321 4.91397101474502e-09 -0.546284851471097 3.40552793858261e-06 miRanda -0.168627634511469 5.31081768756284e-06 NA NA NA hsa-miR-338-3p APC -0.948755228846395 8.99167125682392e-08 -0.546284851471097 3.40552793858261e-06 miRanda -0.157975637349898 2.82707855206972e-08 NA NA NA hsa-miR-374b-5p APC -0.288413933608091 0.0041474558664058 -0.546284851471097 3.40552793858261e-06 mirMAP -0.26053225009571 3.69272696325675e-07 NA NA NA hsa-miR-450b-5p APC 1.25529820885833 1.18847120528666e-15 -0.546284851471097 3.40552793858261e-06 miRNATAP -0.182543010743283 8.21856445012781e-09 NA NA NA hsa-miR-501-3p APC 0.820141346319976 1.74562930463389e-08 -0.546284851471097 3.40552793858261e-06 TargetScan -0.238301982455388 4.74874004351065e-12 NA NA NA hsa-miR-589-3p APC 1.59559692667315 6.2886410639161e-15 -0.546284851471097 3.40552793858261e-06 MirTarget -0.149191828445292 3.49922336833374e-09 NA NA NA hsa-miR-655-3p APC -1.15004187025356 3.60771552708797e-07 -0.546284851471097 3.40552793858261e-06 MirTarget -0.106271133656611 5.01589000788752e-06 NA NA NA hsa-let-7a-5p APC2 -0.439381775414001 3.1119785480023e-05 1.40015307909901 8.15847629068564e-08 TargetScan -0.375729293479308 0.000576259176502018 NA NA NA hsa-let-7a-3p AXIN2 0.0966652362351867 0.423761916840503 -0.654821030558051 0.00118287348398744 miRNATAP -0.35376916882209 1.26715453790834e-06 NA NA NA hsa-miR-103a-3p AXIN2 0.556219385347418 1.55815736455067e-09 -0.654821030558051 0.00118287348398744 miRNAWalker2_validate;MirTarget;miRNATAP -0.325903741654877 0.000625647322873736 NA NA NA hsa-miR-15a-5p AXIN2 0.783550182002274 2.60699595655907e-11 -0.654821030558051 0.00118287348398744 MirTarget;miRNATAP -0.566286065147261 4.5935887109618e-15 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy thyroid cancer hsa-miR-15b-5p AXIN2 0.85315666454713 3.79816274836297e-12 -0.654821030558051 0.00118287348398744 miRTarBase;MirTarget;miRNATAP -0.35176986456837 5.28324433930037e-07 NA NA NA hsa-miR-16-2-3p AXIN2 1.1567130855258 1.01867256952189e-14 -0.654821030558051 0.00118287348398744 mirMAP -0.49217605818279 1.0755436174937e-18 NA NA NA hsa-miR-16-5p AXIN2 0.521122945828175 1.40561786410572e-06 -0.654821030558051 0.00118287348398744 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.516355909847163 1.27186039574774e-10 NA NA NA hsa-miR-205-5p AXIN2 1.50759485376634 2.0003886738248e-16 -0.654821030558051 0.00118287348398744 miRNATAP -0.402750057470777 4.93978195907313e-19 NA NA NA hsa-miR-221-3p AXIN2 0.410625614724387 0.000741090075261272 -0.654821030558051 0.00118287348398744 miRNATAP -0.378135141136746 1.49289375810213e-07 NA NA NA hsa-miR-222-3p AXIN2 1.08197052578759 2.32604040301699e-14 -0.654821030558051 0.00118287348398744 miRNATAP -0.45306601410317 2.45775781095599e-14 NA NA NA hsa-miR-26b-3p AXIN2 0.421575313079363 0.00223298166810883 -0.654821030558051 0.00118287348398744 MirTarget -0.19562586059829 0.00224752439273587 NA NA NA hsa-miR-29a-5p AXIN2 0.323252792625584 0.0370417231222825 -0.654821030558051 0.00118287348398744 MirTarget -0.257731959114779 5.48140564378954e-06 NA NA NA hsa-miR-34a-5p AXIN2 -0.117372471043915 0.364001947180738 -0.654821030558051 0.00118287348398744 miRNAWalker2_validate;miRTarBase -0.183241700018222 0.00764423689823707 23624843 p53 regulates nuclear GSK 3 levels through miR 34 mediated Axin2 suppression in colorectal cancer cells; Exogenous miR-34a decreases Axin2 UTR-reporter activity through multiple binding sites within the 5' and 3' UTR of Axin2; Further RNA transcripts of miR-34 target were correlated with Axin2 in clinical data set of colorectal cancer patients colorectal cancer hsa-miR-3614-5p AXIN2 0.955957969488529 2.95347675446694e-05 -0.654821030558051 0.00118287348398744 MirTarget;miRNATAP -0.18570721643536 1.0495845040705e-06 NA NA NA hsa-miR-429 AXIN2 0.559451508722375 0.00563641638673083 -0.654821030558051 0.00118287348398744 miRanda -0.164290793062077 0.000156578616889057 NA NA NA hsa-miR-582-5p AXIN2 -0.0366995972742474 0.821827119138923 -0.654821030558051 0.00118287348398744 miRNATAP -0.268939077482895 6.0756995308908e-07 NA NA NA hsa-miR-590-3p AXIN2 0.221436901462551 0.0965904764063157 -0.654821030558051 0.00118287348398744 MirTarget;PITA;miRanda;miRNATAP -0.271329539298903 4.21494610216448e-05 NA NA NA hsa-miR-944 AXIN2 1.47323925060177 2.61626403984929e-13 -0.654821030558051 0.00118287348398744 MirTarget;PITA;miRNATAP -0.182407888375862 1.83781560784638e-05 NA NA NA hsa-miR-103a-3p BTRC 0.556219385347418 1.55815736455067e-09 -0.383838847043345 6.07764937720299e-07 MirTarget;miRNATAP -0.195127288018318 6.49428618338955e-08 NA NA NA hsa-miR-130b-3p BTRC 1.44628430084411 9.13980959861273e-24 -0.383838847043345 6.07764937720299e-07 mirMAP -0.135532527047066 9.23862520191604e-10 NA NA NA hsa-miR-130b-5p BTRC 1.77265255049999 1.43627774829684e-29 -0.383838847043345 6.07764937720299e-07 mirMAP -0.133699222917177 2.10371348524703e-11 NA NA NA hsa-miR-15a-5p BTRC 0.783550182002274 2.60699595655907e-11 -0.383838847043345 6.07764937720299e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.174572467294465 3.90645232778685e-10 NA NA NA hsa-miR-15b-5p BTRC 0.85315666454713 3.79816274836297e-12 -0.383838847043345 6.07764937720299e-07 MirTarget;miRNATAP -0.165125615134741 5.59694781681588e-10 NA NA NA hsa-miR-16-1-3p BTRC 0.955017760172879 5.95379292601146e-11 -0.383838847043345 6.07764937720299e-07 mirMAP -0.120132845462012 1.02981409292927e-07 NA NA NA hsa-miR-16-5p BTRC 0.521122945828175 1.40561786410572e-06 -0.383838847043345 6.07764937720299e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.140492227484468 5.77704176099401e-06 NA NA NA hsa-miR-28-5p BTRC -0.026996999089909 0.733047113251652 -0.383838847043345 6.07764937720299e-07 miRanda -0.225694488882788 1.57068578694702e-07 NA NA NA hsa-miR-320a BTRC 0.801356001806321 4.91397101474502e-09 -0.383838847043345 6.07764937720299e-07 miRNAWalker2_validate;PITA -0.143436572641638 2.39851770787459e-09 NA NA NA hsa-miR-342-3p BTRC 0.99756868977753 9.28499866272332e-10 -0.383838847043345 6.07764937720299e-07 mirMAP -0.102049148946382 4.53666000542321e-07 NA NA NA hsa-miR-3913-5p BTRC 0.48532077857571 0.00112373589405304 -0.383838847043345 6.07764937720299e-07 mirMAP -0.136729656162249 1.03435499361847e-09 NA NA NA hsa-miR-505-3p BTRC 0.912823669571645 4.0549774967148e-13 -0.383838847043345 6.07764937720299e-07 MirTarget -0.135458976188229 2.04142565249063e-07 NA NA NA hsa-miR-92a-3p BTRC 0.994679542307232 1.32587679156217e-16 -0.383838847043345 6.07764937720299e-07 miRNAWalker2_validate -0.128154090085504 2.37848689306587e-06 NA NA NA hsa-miR-93-3p BTRC 1.69225547123293 1.50964095575087e-25 -0.383838847043345 6.07764937720299e-07 mirMAP -0.121809769497493 4.71971183483907e-10 NA NA NA hsa-miR-10a-5p CAMK2A -0.316491613573591 0.148093857656453 -1.03224174684661 0.00875475587059639 mirMAP -0.246490202209706 0.00169214052442621 NA NA NA hsa-miR-129-5p CAMK2A -0.246329588499478 0.436451191224681 -1.03224174684661 0.00875475587059639 MirTarget;miRanda -0.143463475040544 0.00933070216758457 NA NA NA hsa-miR-130b-5p CAMK2A 1.77265255049999 1.43627774829684e-29 -1.03224174684661 0.00875475587059639 mirMAP -0.723548262893597 9.94685675937875e-13 NA NA NA hsa-miR-138-5p CAMK2A 0.702468796115049 0.0082478986123581 -1.03224174684661 0.00875475587059639 MirTarget -0.326657309489647 1.67137840001788e-06 NA NA NA hsa-miR-148a-3p CAMK2A -0.428944290834563 0.00954246923521465 -1.03224174684661 0.00875475587059639 miRNATAP -0.660378379366128 1.05155987854933e-10 NA NA NA hsa-miR-148b-5p CAMK2A 1.1533193737265 7.26420964688337e-13 -1.03224174684661 0.00875475587059639 mirMAP -0.360452218840561 0.000662704535229997 NA NA NA hsa-miR-15b-3p CAMK2A 1.05020782493504 6.38723677324836e-14 -1.03224174684661 0.00875475587059639 mirMAP -0.949122966667651 4.67693885316248e-16 NA NA NA hsa-miR-19b-1-5p CAMK2A 0.757034032029085 2.99828133413343e-07 -1.03224174684661 0.00875475587059639 mirMAP -0.691892845979381 1.21775074625619e-09 NA NA NA hsa-miR-205-5p CAMK2A 1.50759485376634 2.0003886738248e-16 -1.03224174684661 0.00875475587059639 mirMAP -0.498639954630246 3.0724369952418e-08 NA NA NA hsa-miR-25-3p CAMK2A 0.76549796417801 3.32282098247097e-11 -1.03224174684661 0.00875475587059639 MirTarget -0.912190419992667 3.01272068383803e-10 NA NA NA hsa-miR-27b-3p CAMK2A -0.732682718863563 2.26896143573324e-09 -1.03224174684661 0.00875475587059639 mirMAP;miRNATAP -0.483333665430612 0.000487309609433834 NA NA NA hsa-miR-30d-5p CAMK2A -0.38399848121878 0.000171129616944749 -1.03224174684661 0.00875475587059639 mirMAP -0.684000877327235 4.80456365108748e-05 NA NA NA hsa-miR-30e-5p CAMK2A -1.02114836019762 6.81961221797866e-17 -1.03224174684661 0.00875475587059639 mirMAP -0.545761951463377 6.33822814254814e-05 NA NA NA hsa-miR-32-5p CAMK2A -0.317310201890053 0.0102525324475293 -1.03224174684661 0.00875475587059639 MirTarget -0.398076350339699 0.00435526257494892 NA NA NA hsa-miR-331-3p CAMK2A 0.906385914819361 4.27653809739414e-11 -1.03224174684661 0.00875475587059639 MirTarget -0.445803313045022 0.000285158226676929 NA NA NA hsa-miR-363-3p CAMK2A -0.608157508016978 0.0186109501272176 -1.03224174684661 0.00875475587059639 MirTarget -0.384606984273218 4.42493576349832e-09 NA NA NA hsa-miR-429 CAMK2A 0.559451508722375 0.00563641638673083 -1.03224174684661 0.00875475587059639 miRNATAP -0.826406791082908 2.37572060397377e-24 NA NA NA hsa-miR-582-3p CAMK2A -0.248056267546012 0.143798829508405 -1.03224174684661 0.00875475587059639 mirMAP -0.403599608992335 6.58233131204743e-05 NA NA NA hsa-miR-7-1-3p CAMK2A 1.13646121619622 1.49823237535933e-14 -1.03224174684661 0.00875475587059639 MirTarget -0.621143561688935 3.24221847038802e-08 NA NA NA hsa-miR-92a-3p CAMK2A 0.994679542307232 1.32587679156217e-16 -1.03224174684661 0.00875475587059639 MirTarget -1.07189717135751 3.04298662850621e-15 NA NA NA hsa-miR-92b-3p CAMK2A 0.869628761112414 4.71129204795212e-09 -1.03224174684661 0.00875475587059639 MirTarget -0.826110611596945 1.56459107538926e-13 NA NA NA hsa-miR-939-5p CAMK2A 1.00479167005165 2.93105661166695e-09 -1.03224174684661 0.00875475587059639 MirTarget -0.346841741685946 0.000996425400258193 NA NA NA hsa-miR-182-5p CAMK2B 1.15060905311096 6.25565852529946e-10 -2.54495725771901 1.0116188879662e-11 mirMAP -0.402768818593056 4.10810631020999e-06 NA NA NA hsa-miR-18a-5p CAMK2B 1.65455873230328 3.76457892277775e-20 -2.54495725771901 1.0116188879662e-11 mirMAP -0.331451405632276 0.000189896399251437 NA NA NA hsa-miR-193b-3p CAMK2B 1.72788400801602 3.0722151264559e-21 -2.54495725771901 1.0116188879662e-11 mirMAP -0.314085250221904 0.000322508771639409 NA NA NA hsa-miR-205-5p CAMK2B 1.50759485376634 2.0003886738248e-16 -2.54495725771901 1.0116188879662e-11 mirMAP -0.622528048072316 5.32686001799156e-13 NA NA NA hsa-miR-2355-5p CAMK2B 1.47205546931107 8.65192179636668e-19 -2.54495725771901 1.0116188879662e-11 mirMAP -0.377348633230487 9.01489823765257e-05 NA NA NA hsa-miR-589-3p CAMK2B 1.59559692667315 6.2886410639161e-15 -2.54495725771901 1.0116188879662e-11 MirTarget -0.396822141971843 1.24971270804495e-06 NA NA NA hsa-miR-940 CAMK2B 1.25303020594374 1.3005368359451e-10 -2.54495725771901 1.0116188879662e-11 PITA;miRNATAP -0.277729160578288 0.00105403212275952 NA NA NA hsa-miR-96-5p CAMK2B 1.42326703011157 4.39736150032373e-14 -2.54495725771901 1.0116188879662e-11 mirMAP -0.423826467059304 6.93419234079453e-07 NA NA NA hsa-miR-17-3p CAMK2D -0.0127974722290336 0.909559935689875 -0.0275549617946957 0.803709891235954 miRNATAP -0.12828096252586 0.00290924580473287 NA NA NA hsa-miR-200b-3p CAMK2D 0.0717138787925347 0.682858087587209 -0.0275549617946957 0.803709891235954 TargetScan;mirMAP -0.111536408469582 4.64765397724122e-05 NA NA NA hsa-miR-28-5p CAMK2D -0.026996999089909 0.733047113251652 -0.0275549617946957 0.803709891235954 miRanda -0.255021482010745 3.62138479164617e-05 NA NA NA hsa-miR-29b-2-5p CAMK2D -0.502720326849742 0.000730448246894952 -0.0275549617946957 0.803709891235954 mirMAP -0.149937333406868 2.99595080791367e-06 NA NA NA hsa-miR-30b-5p CAMK2D -0.400238605368173 0.00346540992719245 -0.0275549617946957 0.803709891235954 miRNATAP -0.14911890424061 2.08011463267032e-05 NA NA NA hsa-miR-30c-5p CAMK2D 0.021222006155897 0.886366656528128 -0.0275549617946957 0.803709891235954 miRNATAP -0.138479143399883 1.9191725758324e-05 NA NA NA hsa-miR-30d-5p CAMK2D -0.38399848121878 0.000171129616944749 -0.0275549617946957 0.803709891235954 miRNATAP -0.173471173391148 0.00023662342839902 NA NA NA hsa-miR-30e-5p CAMK2D -1.02114836019762 6.81961221797866e-17 -0.0275549617946957 0.803709891235954 miRNATAP -0.16101554973522 2.46636776513597e-05 NA NA NA hsa-miR-320a CAMK2D 0.801356001806321 4.91397101474502e-09 -0.0275549617946957 0.803709891235954 miRanda -0.133069505850515 0.000122826086413422 NA NA NA hsa-miR-342-3p CAMK2D 0.99756868977753 9.28499866272332e-10 -0.0275549617946957 0.803709891235954 miRanda -0.146361114379656 3.99266000779319e-07 NA NA NA hsa-miR-374a-3p CAMK2D -0.299190081500425 0.00682975596757891 -0.0275549617946957 0.803709891235954 miRNATAP -0.175156502470854 5.88407334911605e-05 NA NA NA hsa-miR-582-5p CAMK2D -0.0366995972742474 0.821827119138923 -0.0275549617946957 0.803709891235954 mirMAP -0.201849480480769 3.88273033979793e-12 NA NA NA hsa-miR-590-3p CAMK2D 0.221436901462551 0.0965904764063157 -0.0275549617946957 0.803709891235954 miRanda;mirMAP -0.12494009744197 0.00056138296003633 NA NA NA hsa-miR-7-1-3p CAMK2D 1.13646121619622 1.49823237535933e-14 -0.0275549617946957 0.803709891235954 mirMAP -0.152670793525026 1.32749308362875e-06 NA NA NA hsa-miR-181a-5p CAMK2G 0.819060835827404 1.38616688310277e-13 -0.24349929142398 0.00139531114950643 miRNATAP -0.105926436099968 0.000310387255066661 NA NA NA hsa-miR-181b-5p CAMK2G 0.974255518824355 2.64876280203475e-16 -0.24349929142398 0.00139531114950643 miRNATAP -0.103275328507572 0.000139777576574626 NA NA NA hsa-let-7g-5p CCND1 -0.250780249469264 0.00939610188330072 -0.0109881197784345 0.959465409721582 miRNATAP -0.424829740163156 1.3974509451707e-05 NA NA NA hsa-miR-106a-5p CCND1 0.67978010057847 0.00221925869726092 -0.0109881197784345 0.959465409721582 MirTarget;miRNATAP -0.290355514799433 2.22440819238953e-12 NA NA NA hsa-miR-1266-5p CCND1 -0.595481713934774 0.0201336437562675 -0.0109881197784345 0.959465409721582 MirTarget -0.139245086566564 0.000186104290921039 NA NA NA hsa-miR-142-3p CCND1 1.12754191614028 1.68798138028946e-08 -0.0109881197784345 0.959465409721582 miRanda -0.212388247517233 4.15485864028608e-06 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colon cancer hsa-miR-142-5p CCND1 0.288897753038094 0.0900009317815725 -0.0109881197784345 0.959465409721582 PITA -0.191106128320911 0.000532572974747186 NA NA NA hsa-miR-150-5p CCND1 -0.243749814009231 0.331546276920338 -0.0109881197784345 0.959465409721582 mirMAP -0.180131286994855 1.27780213542857e-06 NA NA NA hsa-miR-155-5p CCND1 0.533437622040649 0.00248671179205372 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.205881873012998 0.000104382699617692 26955820 MicroRNA 155 expression inversely correlates with pathologic stage of gastric cancer and it inhibits gastric cancer cell growth by targeting cyclin D1 staging gastric cancer hsa-miR-15a-5p CCND1 0.783550182002274 2.60699595655907e-11 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.320464086146859 4.59241835770022e-05 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-15b-5p CCND1 0.85315666454713 3.79816274836297e-12 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.196519284459032 0.00913339894150689 NA NA NA hsa-miR-16-1-3p CCND1 0.955017760172879 5.95379292601146e-11 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase -0.299307340787817 2.12501301813106e-06 22922827;18483394 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ; sarcoma;lymphoma hsa-miR-16-5p CCND1 0.521122945828175 1.40561786410572e-06 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.36160545188711 2.92815156758109e-05 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-19a-3p CCND1 1.35800152353624 2.80940447111944e-12 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;miRNATAP -0.12556465980021 0.0080645437414565 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 0.757034032029085 2.99828133413343e-07 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase -0.202417906859997 0.00132907107963613 NA NA NA hsa-miR-19b-3p CCND1 0.538732279378089 0.000622008277870679 -0.0109881197784345 0.959465409721582 miRNATAP -0.231848363677157 9.5371115518645e-05 NA NA NA hsa-miR-20a-5p CCND1 1.1531986665452 1.02385132917958e-11 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.150528956777027 0.00569825749150082 NA NA NA hsa-miR-20b-5p CCND1 0.345967670847176 0.232014828043601 -0.0109881197784345 0.959465409721582 MirTarget;miRNATAP -0.250103392191291 2.8858693936891e-15 NA NA NA hsa-miR-29b-3p CCND1 -0.110721443686039 0.511264554091106 -0.0109881197784345 0.959465409721582 mirMAP -0.182509877041615 0.00109069300418897 NA NA NA hsa-miR-29c-3p CCND1 -2.08166260448948 8.3238369390898e-24 -0.0109881197784345 0.959465409721582 mirMAP -0.163903476961256 0.000152217345834049 NA NA NA hsa-miR-33a-3p CCND1 0.20371038027126 0.212335697664505 -0.0109881197784345 0.959465409721582 MirTarget -0.204409670414224 0.000471939794699908 NA NA NA hsa-miR-34a-5p CCND1 -0.117372471043915 0.364001947180738 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate;miRTarBase;miRNATAP -0.309736660444851 2.09961171943065e-05 25792709;21399894 This inhibition of proliferation was associated with a decrease in cyclin D1 levels orchestrated principally by HNF-4α a target of miR-34a considered to act as a tumour suppressor in the liver;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a ; liver cancer;breast cancer hsa-miR-425-5p CCND1 0.931027421598738 6.46235724408844e-08 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.149225802492201 0.00573052989307961 NA NA NA hsa-miR-497-5p CCND1 -0.966244470847844 5.26505649147857e-12 -0.0109881197784345 0.959465409721582 MirTarget;miRNATAP -0.266892367444044 4.86480308910068e-05 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-590-3p CCND1 0.221436901462551 0.0965904764063157 -0.0109881197784345 0.959465409721582 mirMAP -0.238086291527056 0.000767975801470639 NA NA NA hsa-miR-7-1-3p CCND1 1.13646121619622 1.49823237535933e-14 -0.0109881197784345 0.959465409721582 mirMAP -0.221180507811752 0.000359772635429063 NA NA NA hsa-miR-9-5p CCND1 1.65694862043766 2.08325802567323e-05 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.135043708232949 1.13694784335034e-08 NA NA NA hsa-miR-92a-3p CCND1 0.994679542307232 1.32587679156217e-16 -0.0109881197784345 0.959465409721582 miRNAWalker2_validate -0.235491439560111 0.00199944237198536 NA NA NA hsa-miR-942-5p CCND1 0.678652135586536 2.58063518495056e-07 -0.0109881197784345 0.959465409721582 MirTarget -0.230928848103094 0.0011113987419772 NA NA NA hsa-miR-224-3p CCND2 0.502645536188015 0.0081142387260641 0.148711904010299 0.532420631377314 mirMAP -0.312870902501466 8.12446049333883e-09 NA NA NA hsa-miR-27b-3p CCND3 -0.732682718863563 2.26896143573324e-09 -0.048043868607146 0.631560985924681 miRNAWalker2_validate -0.132150579088403 0.000160876577060277 NA NA NA hsa-miR-140-5p CHD8 -0.412389003031485 0.000136051708543369 0.0955700899218437 0.231861872303383 miRanda -0.108619115724322 0.000713244223765146 NA NA NA hsa-let-7a-3p CREBBP 0.0966652362351867 0.423761916840503 0.0211259388253167 0.833615761874968 miRNATAP -0.141728011100707 9.23516643213276e-05 NA NA NA hsa-miR-186-5p CREBBP 0.353452958261612 0.000145058448579496 0.0211259388253167 0.833615761874968 mirMAP;miRNATAP -0.266935526900469 1.07011235526747e-08 NA NA NA hsa-miR-26b-5p CREBBP -0.254478038884324 0.0285227763044636 0.0211259388253167 0.833615761874968 miRNATAP -0.214346125460379 9.40206492009562e-09 NA NA NA hsa-miR-30d-3p CREBBP -0.577371911152798 2.02950840095287e-06 0.0211259388253167 0.833615761874968 MirTarget;miRNATAP -0.125103816738256 0.000472569063529424 NA NA NA hsa-miR-590-3p CREBBP 0.221436901462551 0.0965904764063157 0.0211259388253167 0.833615761874968 PITA;miRanda;mirMAP;miRNATAP -0.10121443711021 0.00207914002999387 NA NA NA hsa-miR-130b-5p CSNK1A1 1.77265255049999 1.43627774829684e-29 -0.0678841653273512 0.477676331500234 mirMAP -0.20105874729165 1.23374004200915e-16 NA NA NA hsa-miR-186-5p CSNK1A1 0.353452958261612 0.000145058448579496 -0.0678841653273512 0.477676331500234 miRNAWalker2_validate;miRNATAP -0.130885588371487 0.00354218757548992 NA NA NA hsa-miR-30a-5p CSNK1A1 -1.79779915425811 1.93360169837799e-26 -0.0678841653273512 0.477676331500234 MirTarget;miRNATAP -0.154112018482441 1.87051174955458e-11 NA NA NA hsa-miR-30b-5p CSNK1A1 -0.400238605368173 0.00346540992719245 -0.0678841653273512 0.477676331500234 MirTarget;mirMAP;miRNATAP -0.147890066190575 9.02753661711751e-07 NA NA NA hsa-miR-30c-5p CSNK1A1 0.021222006155897 0.886366656528128 -0.0678841653273512 0.477676331500234 MirTarget;mirMAP;miRNATAP -0.11310065227503 5.19364828797197e-05 NA NA NA hsa-miR-30d-5p CSNK1A1 -0.38399848121878 0.000171129616944749 -0.0678841653273512 0.477676331500234 MirTarget;miRNATAP -0.16165848715286 6.90359800670376e-05 NA NA NA hsa-miR-30e-5p CSNK1A1 -1.02114836019762 6.81961221797866e-17 -0.0678841653273512 0.477676331500234 MirTarget -0.100745695816715 0.00229041872695659 NA NA NA hsa-miR-320a CSNK1A1 0.801356001806321 4.91397101474502e-09 -0.0678841653273512 0.477676331500234 mirMAP -0.178587618471858 1.51730897083135e-09 NA NA NA hsa-miR-320b CSNK1A1 1.23473838180754 3.04337566045537e-14 -0.0678841653273512 0.477676331500234 mirMAP -0.125255735926911 4.00919352204136e-07 NA NA NA hsa-miR-324-3p CSNK1A1 0.867391246413545 3.63808540490361e-10 -0.0678841653273512 0.477676331500234 miRNAWalker2_validate -0.108298376213523 0.000242301811583602 NA NA NA hsa-miR-335-3p CSNK1A1 0.336785882180547 0.0542446207938138 -0.0678841653273512 0.477676331500234 mirMAP -0.193409295192757 4.75110988319189e-17 NA NA NA hsa-miR-340-5p CSNK1A1 -0.608415693437977 4.44345153563513e-05 -0.0678841653273512 0.477676331500234 mirMAP -0.151429141520868 3.45075256337826e-08 NA NA NA hsa-miR-491-5p CSNK1A1 -0.541680329196715 0.00135829217561865 -0.0678841653273512 0.477676331500234 miRanda -0.117059208211999 4.36399918176242e-06 NA NA NA hsa-miR-501-3p CSNK1A1 0.820141346319976 1.74562930463389e-08 -0.0678841653273512 0.477676331500234 TargetScan;miRNATAP -0.117903331799247 2.73711577175012e-05 NA NA NA hsa-miR-502-3p CSNK1A1 -0.165138869760313 0.106881047403914 -0.0678841653273512 0.477676331500234 miRNATAP -0.12032724996939 0.00325321090106498 NA NA NA hsa-miR-664a-3p CSNK1A1 -0.256108763664991 0.0513188660751664 -0.0678841653273512 0.477676331500234 mirMAP -0.188361453439418 1.72438486192553e-09 NA NA NA hsa-miR-664a-5p CSNK1A1 -0.871809752100072 1.86842520324979e-08 -0.0678841653273512 0.477676331500234 MirTarget -0.189351176823546 3.17222035439073e-13 NA NA NA hsa-miR-9-5p CSNK1A1 1.65694862043766 2.08325802567323e-05 -0.0678841653273512 0.477676331500234 miRNATAP -0.100548613685476 2.82062779189847e-23 NA NA NA hsa-miR-28-3p CSNK1A1L 0.459875450032895 3.47095927872566e-07 -0.213192792159322 0.114468999275029 PITA -0.300661143571673 3.51286429443961e-06 NA NA NA hsa-miR-491-5p CSNK1A1L -0.541680329196715 0.00135829217561865 -0.213192792159322 0.114468999275029 PITA;miRanda -0.10771303010449 0.00301130046152117 NA NA NA hsa-miR-590-3p CSNK1A1L 0.221436901462551 0.0965904764063157 -0.213192792159322 0.114468999275029 mirMAP -0.123158540664181 0.0054340399696762 NA NA NA hsa-miR-148a-5p CSNK1E -1.00478606532747 1.38045244999229e-07 0.548936364081841 1.10720819240592e-10 miRNATAP -0.116497957841565 1.41533291460369e-09 NA NA NA hsa-miR-126-5p CSNK2A2 -0.953529188793816 7.91719143295591e-16 0.115028503367429 0.114060400317523 mirMAP -0.102234389087127 8.13744725300302e-05 NA NA NA hsa-miR-181c-5p CSNK2A2 -0.168991199007857 0.196949106150297 0.115028503367429 0.114060400317523 mirMAP -0.19999876862637 1.65449492969672e-17 NA NA NA hsa-miR-23b-3p CSNK2A2 -0.497563803223134 3.31483353357535e-05 0.115028503367429 0.114060400317523 miRNATAP -0.150005105263907 7.75821469712124e-09 NA NA NA hsa-miR-30d-3p CSNK2A2 -0.577371911152798 2.02950840095287e-06 0.115028503367429 0.114060400317523 mirMAP -0.126711170272987 8.34307554953998e-07 NA NA NA hsa-miR-30e-3p CSNK2A2 -0.890635378639789 1.65740480611339e-16 0.115028503367429 0.114060400317523 mirMAP -0.128806428119221 5.61798875076103e-06 NA NA NA hsa-miR-32-5p CSNK2A2 -0.317310201890053 0.0102525324475293 0.115028503367429 0.114060400317523 mirMAP -0.106323308973511 3.06556082829048e-05 NA NA NA hsa-miR-374a-5p CSNK2A2 -0.621903385111545 6.61791773205282e-12 0.115028503367429 0.114060400317523 mirMAP -0.126342760000521 0.000244343002322113 NA NA NA hsa-let-7a-3p CTNNB1 0.0966652362351867 0.423761916840503 -0.300300567639502 0.00163620046474668 MirTarget;miRNATAP -0.133594372296952 0.000109116957423689 NA NA NA hsa-miR-320a CTNNB1 0.801356001806321 4.91397101474502e-09 -0.300300567639502 0.00163620046474668 PITA;miRanda;miRNATAP -0.127056972080136 2.1032822504976e-05 NA NA NA hsa-miR-532-3p CTNNB1 0.80240056676907 1.08989551712617e-09 -0.300300567639502 0.00163620046474668 miRNAWalker2_validate -0.14291782747995 4.05395930207998e-06 NA NA NA hsa-miR-7-1-3p CTNNB1 1.13646121619622 1.49823237535933e-14 -0.300300567639502 0.00163620046474668 mirMAP -0.127239564192006 3.10292737404531e-06 NA NA NA hsa-miR-10a-5p CTNNBIP1 -0.316491613573591 0.148093857656453 -0.44569265758819 0.000219308282075149 miRNATAP -0.13089037543128 4.0576724301721e-08 NA NA NA hsa-miR-125b-5p CTNNBIP1 -0.993460109818276 5.07736727659894e-12 -0.44569265758819 0.000219308282075149 mirMAP -0.112726027417391 0.00171920788389895 NA NA NA hsa-miR-188-5p CTNNBIP1 0.559328953885106 0.000430338888594543 -0.44569265758819 0.000219308282075149 PITA;miRNATAP -0.10117625965354 0.00233114840667026 NA NA NA hsa-miR-192-5p CTNNBIP1 0.380924502586635 0.00986961967409205 -0.44569265758819 0.000219308282075149 miRNAWalker2_validate;MirTarget;miRNATAP -0.187356899945264 1.23103464975791e-07 NA NA NA hsa-miR-215-5p CTNNBIP1 -0.757663683237828 5.72998183244808e-05 -0.44569265758819 0.000219308282075149 miRNAWalker2_validate;MirTarget -0.143633146280191 2.31725769212918e-07 NA NA NA hsa-miR-26a-5p CTNNBIP1 -1.09269574587169 1.24020612216319e-22 -0.44569265758819 0.000219308282075149 miRNATAP -0.20918727399644 3.78763735564603e-06 NA NA NA hsa-miR-28-5p CTNNBIP1 -0.026996999089909 0.733047113251652 -0.44569265758819 0.000219308282075149 MirTarget;miRanda -0.684160729749766 3.80176228666613e-26 NA NA NA hsa-miR-32-5p CTNNBIP1 -0.317310201890053 0.0102525324475293 -0.44569265758819 0.000219308282075149 miRNATAP -0.122517974533133 0.00422041440718455 NA NA NA hsa-miR-335-5p CTNNBIP1 -1.17227779671552 1.49282618530733e-10 -0.44569265758819 0.000219308282075149 miRNAWalker2_validate;mirMAP -0.105605873951292 0.000184895787762754 NA NA NA hsa-miR-421 CTNNBIP1 0.945488088619653 2.35762398527362e-09 -0.44569265758819 0.000219308282075149 miRanda;mirMAP -0.170549584880701 1.76922873949607e-07 NA NA NA hsa-miR-625-5p CTNNBIP1 0.346770617079364 0.02860843739549 -0.44569265758819 0.000219308282075149 mirMAP -0.213358053007188 1.01644709066331e-10 NA NA NA hsa-miR-92b-3p CTNNBIP1 0.869628761112414 4.71129204795212e-09 -0.44569265758819 0.000219308282075149 miRNATAP -0.238782981562176 4.0479014802118e-12 NA NA NA hsa-let-7g-3p DAAM1 0.637019243992294 0.000204623048574065 -0.372170920307328 0.0295090929598095 MirTarget -0.117433471801551 0.00667509930379399 NA NA NA hsa-miR-125a-5p DAAM1 0.215366061934933 0.119550904549401 -0.372170920307328 0.0295090929598095 MirTarget -0.314539342771256 3.85670495870538e-09 NA NA NA hsa-miR-125b-5p DAAM1 -0.993460109818276 5.07736727659894e-12 -0.372170920307328 0.0295090929598095 MirTarget;miRNATAP -0.347484688906985 3.28928552403519e-12 NA NA NA hsa-miR-130b-3p DAAM1 1.44628430084411 9.13980959861273e-24 -0.372170920307328 0.0295090929598095 MirTarget;miRNATAP -0.290871994075301 2.85099207415399e-09 NA NA NA hsa-miR-130b-5p DAAM1 1.77265255049999 1.43627774829684e-29 -0.372170920307328 0.0295090929598095 MirTarget -0.307711194836089 2.74139521432105e-12 NA NA NA hsa-miR-140-5p DAAM1 -0.412389003031485 0.000136051708543369 -0.372170920307328 0.0295090929598095 miRanda -0.35426765397042 2.32304072544327e-07 NA NA NA hsa-miR-142-3p DAAM1 1.12754191614028 1.68798138028946e-08 -0.372170920307328 0.0295090929598095 miRanda -0.120871911530685 0.00100164654904123 NA NA NA hsa-miR-181a-5p DAAM1 0.819060835827404 1.38616688310277e-13 -0.372170920307328 0.0295090929598095 mirMAP -0.342143663813159 1.79758921189328e-07 NA NA NA hsa-miR-181b-5p DAAM1 0.974255518824355 2.64876280203475e-16 -0.372170920307328 0.0295090929598095 mirMAP -0.175246297220106 0.00413958177180762 NA NA NA hsa-miR-181c-5p DAAM1 -0.168991199007857 0.196949106150297 -0.372170920307328 0.0295090929598095 mirMAP -0.367687433531677 6.34038536422097e-11 NA NA NA hsa-miR-182-5p DAAM1 1.15060905311096 6.25565852529946e-10 -0.372170920307328 0.0295090929598095 miRNATAP -0.149898934309091 0.000136304402217923 NA NA NA hsa-miR-186-5p DAAM1 0.353452958261612 0.000145058448579496 -0.372170920307328 0.0295090929598095 MirTarget;mirMAP -0.415039095173817 2.05358205479174e-07 NA NA NA hsa-miR-194-5p DAAM1 -0.0214221838459805 0.872940154118701 -0.372170920307328 0.0295090929598095 miRNATAP -0.438567817551361 8.1015522065339e-16 NA NA NA hsa-miR-19a-3p DAAM1 1.35800152353624 2.80940447111944e-12 -0.372170920307328 0.0295090929598095 miRNATAP -0.161566461457992 1.51607351743627e-05 NA NA NA hsa-miR-19b-3p DAAM1 0.538732279378089 0.000622008277870679 -0.372170920307328 0.0295090929598095 miRNATAP -0.245355677501977 1.58894166832331e-07 NA NA NA hsa-miR-21-5p DAAM1 1.62465922021121 3.44191300985109e-58 -0.372170920307328 0.0295090929598095 miRNAWalker2_validate -0.223306419870481 0.000720553022123093 NA NA NA hsa-miR-218-5p DAAM1 -1.0725338636959 3.61493686604269e-09 -0.372170920307328 0.0295090929598095 MirTarget;miRNATAP -0.284757981785269 6.38285119089134e-13 NA NA NA hsa-miR-29b-3p DAAM1 -0.110721443686039 0.511264554091106 -0.372170920307328 0.0295090929598095 MirTarget;miRNATAP -0.27225723441245 4.61606154902185e-10 NA NA NA hsa-miR-301a-3p DAAM1 2.14132004241926 4.46255413526808e-25 -0.372170920307328 0.0295090929598095 MirTarget;miRNATAP -0.146071157590598 1.85999121657136e-05 NA NA NA hsa-miR-32-5p DAAM1 -0.317310201890053 0.0102525324475293 -0.372170920307328 0.0295090929598095 miRNATAP -0.278387689799525 3.66473588624993e-06 NA NA NA hsa-miR-320a DAAM1 0.801356001806321 4.91397101474502e-09 -0.372170920307328 0.0295090929598095 miRanda -0.365250867324386 4.58541196186686e-12 NA NA NA hsa-miR-320b DAAM1 1.23473838180754 3.04337566045537e-14 -0.372170920307328 0.0295090929598095 miRanda -0.210023371579202 2.30902730785628e-06 NA NA NA hsa-miR-335-3p DAAM1 0.336785882180547 0.0542446207938138 -0.372170920307328 0.0295090929598095 mirMAP -0.236148209669718 2.12720775200026e-08 NA NA NA hsa-miR-335-5p DAAM1 -1.17227779671552 1.49282618530733e-10 -0.372170920307328 0.0295090929598095 miRNAWalker2_validate;MirTarget;miRNATAP -0.150860683977064 0.000156894945310016 NA NA NA hsa-miR-34a-5p DAAM1 -0.117372471043915 0.364001947180738 -0.372170920307328 0.0295090929598095 MirTarget;miRNATAP -0.568239696155622 1.05101253816867e-24 NA NA NA hsa-miR-429 DAAM1 0.559451508722375 0.00563641638673083 -0.372170920307328 0.0295090929598095 miRNATAP -0.131436791427559 0.000343698987768739 NA NA NA hsa-miR-454-3p DAAM1 1.54137391927201 4.15861570449376e-20 -0.372170920307328 0.0295090929598095 MirTarget;miRNATAP -0.268107988328816 1.99576269604876e-10 NA NA NA hsa-miR-500a-3p DAAM1 0.457959128173392 0.000691656736597067 -0.372170920307328 0.0295090929598095 MirTarget -0.368878522195113 1.01974367861889e-11 NA NA NA hsa-miR-576-5p DAAM1 0.940432050128373 6.90227595663302e-12 -0.372170920307328 0.0295090929598095 mirMAP -0.196301126652653 0.000230220811437136 NA NA NA hsa-miR-590-3p DAAM1 0.221436901462551 0.0965904764063157 -0.372170920307328 0.0295090929598095 MirTarget;miRanda;mirMAP -0.196023777012943 0.00047043898663172 NA NA NA hsa-miR-92a-3p DAAM1 0.994679542307232 1.32587679156217e-16 -0.372170920307328 0.0295090929598095 miRNATAP -0.323178363857685 6.5673748868934e-08 NA NA NA hsa-miR-96-5p DAAM1 1.42326703011157 4.39736150032373e-14 -0.372170920307328 0.0295090929598095 TargetScan;miRNATAP -0.160632052239002 2.84733455033793e-05 NA NA NA hsa-miR-138-5p DAAM2 0.702468796115049 0.0082478986123581 -0.578673106453096 0.011610767639441 miRNATAP -0.123822330266652 0.00193558323269901 NA NA NA hsa-miR-141-5p DAAM2 0.623874471326586 0.0018690552472983 -0.578673106453096 0.011610767639441 mirMAP -0.378753349136517 5.76321970222427e-15 NA NA NA hsa-miR-146b-5p DAAM2 0.917975986853978 3.33749259316025e-09 -0.578673106453096 0.011610767639441 miRanda -0.204872862618948 0.0012686790486551 NA NA NA hsa-miR-182-5p DAAM2 1.15060905311096 6.25565852529946e-10 -0.578673106453096 0.011610767639441 mirMAP -0.325803110844119 4.16380378364657e-10 NA NA NA hsa-miR-18a-5p DAAM2 1.65455873230328 3.76457892277775e-20 -0.578673106453096 0.011610767639441 miRNAWalker2_validate -0.537945598982495 5.49075720854227e-26 NA NA NA hsa-miR-193a-3p DAAM2 0.22120710726779 0.111827069464729 -0.578673106453096 0.011610767639441 miRanda -0.32210869528282 7.22131286958963e-06 NA NA NA hsa-miR-1976 DAAM2 0.638808083289405 2.94840228896364e-07 -0.578673106453096 0.011610767639441 mirMAP -0.46976395093275 2.49273098674609e-09 NA NA NA hsa-miR-19b-3p DAAM2 0.538732279378089 0.000622008277870679 -0.578673106453096 0.011610767639441 miRNAWalker2_validate -0.648845459331553 5.26179647600864e-27 NA NA NA hsa-miR-205-5p DAAM2 1.50759485376634 2.0003886738248e-16 -0.578673106453096 0.011610767639441 mirMAP -0.596050805404064 4.04404061854897e-33 NA NA NA hsa-miR-339-5p DAAM2 1.07771430326938 2.45772601859307e-09 -0.578673106453096 0.011610767639441 miRanda -0.48699457762384 2.11027158627134e-20 NA NA NA hsa-miR-361-3p DAAM2 0.272298288982435 0.0147874880476998 -0.578673106453096 0.011610767639441 mirMAP -0.385355616016065 1.72200331680283e-05 NA NA NA hsa-miR-429 DAAM2 0.559451508722375 0.00563641638673083 -0.578673106453096 0.011610767639441 miRNATAP -0.443056683009619 1.32250212447329e-20 NA NA NA hsa-miR-589-3p DAAM2 1.59559692667315 6.2886410639161e-15 -0.578673106453096 0.011610767639441 mirMAP -0.37796960026417 5.48173050449173e-15 NA NA NA hsa-miR-590-3p DAAM2 0.221436901462551 0.0965904764063157 -0.578673106453096 0.011610767639441 miRanda;mirMAP -0.450178580093225 1.43531248500036e-09 NA NA NA hsa-miR-9-5p DAAM2 1.65694862043766 2.08325802567323e-05 -0.578673106453096 0.011610767639441 mirMAP -0.106468516583638 2.66011815859745e-05 NA NA NA hsa-miR-193a-3p DKK2 0.22120710726779 0.111827069464729 -0.435514545987033 0.0964879459934569 miRanda -0.333129540780387 4.90168722353049e-05 NA NA NA hsa-miR-221-3p DKK2 0.410625614724387 0.000741090075261272 -0.435514545987033 0.0964879459934569 miRNAWalker2_validate;miRTarBase -0.333299105923536 0.000377800618396652 NA NA NA hsa-miR-27a-3p DKK2 0.348456440505425 0.00126682892514312 -0.435514545987033 0.0964879459934569 miRNATAP -0.483018208727428 4.61510791970132e-06 NA NA NA hsa-miR-324-5p DKK2 1.66709479707179 1.45961450445769e-23 -0.435514545987033 0.0964879459934569 miRanda -0.445312216529107 4.43118328714388e-12 NA NA NA hsa-miR-33a-3p DKK2 0.20371038027126 0.212335697664505 -0.435514545987033 0.0964879459934569 mirMAP -0.364167152998087 2.37819314844048e-07 NA NA NA hsa-miR-3607-3p DKK2 1.01377165357363 9.13355519701165e-05 -0.435514545987033 0.0964879459934569 miRNATAP -0.185012122638788 2.19375166527863e-05 NA NA NA hsa-miR-455-5p DKK2 1.408595672323 5.52039116456697e-22 -0.435514545987033 0.0964879459934569 miRanda -0.406469238656099 4.51190895120257e-08 NA NA NA hsa-miR-576-5p DKK2 0.940432050128373 6.90227595663302e-12 -0.435514545987033 0.0964879459934569 mirMAP -0.585051926228948 2.82075756810526e-13 NA NA NA hsa-miR-590-3p DKK2 0.221436901462551 0.0965904764063157 -0.435514545987033 0.0964879459934569 miRanda;mirMAP;miRNATAP -0.356167055219017 3.2115873064257e-05 NA NA NA hsa-miR-590-5p DKK2 0.763025362395968 3.65305892505623e-09 -0.435514545987033 0.0964879459934569 miRanda -0.658764670674801 1.07653306362127e-14 NA NA NA hsa-miR-944 DKK2 1.47323925060177 2.61626403984929e-13 -0.435514545987033 0.0964879459934569 mirMAP -0.238783123615292 1.4438958429012e-05 NA NA NA hsa-miR-107 DVL1 -0.0447040564279497 0.671618791096755 -0.315083254913112 0.00336463703005417 PITA;miRanda -0.353957434868849 5.20660445094226e-16 NA NA NA hsa-miR-378a-3p DVL1 -1.50453783521372 9.41694954361173e-17 -0.315083254913112 0.00336463703005417 miRNAWalker2_validate -0.10296338019986 3.82097488279943e-05 NA NA NA hsa-miR-744-5p DVL1 0.436098372735845 0.000850400989351181 -0.315083254913112 0.00336463703005417 miRNAWalker2_validate -0.109422905940439 0.00226270986598123 NA NA NA hsa-miR-125a-5p DVL3 0.215366061934933 0.119550904549401 0.761578628594005 2.30416706929068e-12 PITA -0.122644441122875 0.000449656811680475 NA NA NA hsa-miR-146b-3p DVL3 0.186534815310862 0.169137114997759 0.761578628594005 2.30416706929068e-12 MirTarget -0.109853957067874 0.00209625870175301 NA NA NA hsa-miR-26b-5p DVL3 -0.254478038884324 0.0285227763044636 0.761578628594005 2.30416706929068e-12 miRNAWalker2_validate -0.206441831856518 6.28828682878475e-07 NA NA NA hsa-miR-29b-2-5p DVL3 -0.502720326849742 0.000730448246894952 0.761578628594005 2.30416706929068e-12 MirTarget -0.108629722692568 0.000781479246536973 NA NA NA hsa-miR-30d-3p DVL3 -0.577371911152798 2.02950840095287e-06 0.761578628594005 2.30416706929068e-12 MirTarget -0.143044131405002 0.000298094745922076 NA NA NA hsa-miR-338-3p DVL3 -0.948755228846395 8.99167125682392e-08 0.761578628594005 2.30416706929068e-12 miRanda -0.20337710422478 9.09837146114886e-15 NA NA NA hsa-miR-140-5p EP300 -0.412389003031485 0.000136051708543369 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate -0.141884309868302 0.00916642161638672 NA NA NA hsa-miR-181b-5p EP300 0.974255518824355 2.64876280203475e-16 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate -0.250341020065621 1.51463026672172e-07 NA NA NA hsa-miR-182-5p EP300 1.15060905311096 6.25565852529946e-10 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate;miRNATAP -0.109993574014164 0.000382060836125653 NA NA NA hsa-miR-186-5p EP300 0.353452958261612 0.000145058448579496 -0.0380111788778681 0.77827759766468 miRNATAP -0.386320760182696 6.6698828838652e-10 NA NA NA hsa-miR-193b-3p EP300 1.72788400801602 3.0722151264559e-21 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate -0.144257938177827 2.54219199927362e-06 NA NA NA hsa-miR-20a-5p EP300 1.1531986665452 1.02385132917958e-11 -0.0380111788778681 0.77827759766468 miRNATAP -0.261739041685133 2.59407474239911e-15 NA NA NA hsa-miR-2355-3p EP300 1.58434563546762 4.06578912176206e-18 -0.0380111788778681 0.77827759766468 MirTarget;miRNATAP -0.131467353710323 2.13937266933203e-05 NA NA NA hsa-miR-25-3p EP300 0.76549796417801 3.32282098247097e-11 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate -0.173479800768433 0.000532079071469301 NA NA NA hsa-miR-26b-5p EP300 -0.254478038884324 0.0285227763044636 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate;miRNATAP -0.321924572744021 1.18737211357222e-10 NA NA NA hsa-miR-29b-1-5p EP300 1.39669186711325 4.36960953138935e-11 -0.0380111788778681 0.77827759766468 MirTarget -0.175659831997499 5.2666018029895e-11 NA NA NA hsa-miR-30c-5p EP300 0.021222006155897 0.886366656528128 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate -0.354080729396632 2.09783714269189e-20 NA NA NA hsa-miR-30d-3p EP300 -0.577371911152798 2.02950840095287e-06 -0.0380111788778681 0.77827759766468 MirTarget;miRNATAP -0.181263177214702 0.000161995559394236 NA NA NA hsa-miR-339-5p EP300 1.07771430326938 2.45772601859307e-09 -0.0380111788778681 0.77827759766468 miRanda -0.252101380951511 5.72291428931759e-16 NA NA NA hsa-miR-342-3p EP300 0.99756868977753 9.28499866272332e-10 -0.0380111788778681 0.77827759766468 MirTarget;PITA;miRanda;miRNATAP -0.275927662915398 1.41235573597807e-15 NA NA NA hsa-miR-361-3p EP300 0.272298288982435 0.0147874880476998 -0.0380111788778681 0.77827759766468 PITA -0.220028179879572 2.87377466725932e-05 NA NA NA hsa-miR-374b-5p EP300 -0.288413933608091 0.0041474558664058 -0.0380111788778681 0.77827759766468 mirMAP;miRNATAP -0.289679382753077 6.67702137205187e-07 NA NA NA hsa-miR-582-3p EP300 -0.248056267546012 0.143798829508405 -0.0380111788778681 0.77827759766468 MirTarget;PITA -0.110822669216861 0.00136211075647265 NA NA NA hsa-miR-590-3p EP300 0.221436901462551 0.0965904764063157 -0.0380111788778681 0.77827759766468 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.124953760048753 0.00471850055107272 NA NA NA hsa-miR-92a-3p EP300 0.994679542307232 1.32587679156217e-16 -0.0380111788778681 0.77827759766468 miRNAWalker2_validate -0.192864139618897 4.68840854466291e-05 NA NA NA hsa-miR-96-5p EP300 1.42326703011157 4.39736150032373e-14 -0.0380111788778681 0.77827759766468 TargetScan;miRNATAP -0.119689767979309 7.57146931270777e-05 NA NA NA hsa-miR-130a-3p FBXW11 0.67051191119964 4.89747518735144e-06 -0.522572976947842 4.41162314947416e-11 MirTarget -0.149633140410536 1.6229332714645e-10 NA NA NA hsa-miR-130b-3p FBXW11 1.44628430084411 9.13980959861273e-24 -0.522572976947842 4.41162314947416e-11 MirTarget -0.129277578106721 2.17081583533824e-08 NA NA NA hsa-miR-17-5p FBXW11 1.41924888736771 2.75805544953758e-18 -0.522572976947842 4.41162314947416e-11 TargetScan;miRNATAP -0.149464465054655 2.47315320459538e-13 NA NA NA hsa-miR-182-5p FBXW11 1.15060905311096 6.25565852529946e-10 -0.522572976947842 4.41162314947416e-11 MirTarget;miRNATAP -0.120747941011624 3.60841314193127e-11 NA NA NA hsa-miR-186-5p FBXW11 0.353452958261612 0.000145058448579496 -0.522572976947842 4.41162314947416e-11 mirMAP -0.13312953977449 0.000439791124138411 NA NA NA hsa-miR-19a-3p FBXW11 1.35800152353624 2.80940447111944e-12 -0.522572976947842 4.41162314947416e-11 MirTarget -0.130912274169801 3.32267780243271e-14 NA NA NA hsa-miR-19b-3p FBXW11 0.538732279378089 0.000622008277870679 -0.522572976947842 4.41162314947416e-11 MirTarget -0.136461162780345 4.76330312426609e-10 NA NA NA hsa-miR-20a-5p FBXW11 1.1531986665452 1.02385132917958e-11 -0.522572976947842 4.41162314947416e-11 miRNATAP -0.142819638281362 6.93694872629742e-13 NA NA NA hsa-miR-301a-3p FBXW11 2.14132004241926 4.46255413526808e-25 -0.522572976947842 4.41162314947416e-11 MirTarget -0.117240857080766 1.10194975126046e-13 NA NA NA hsa-miR-374b-5p FBXW11 -0.288413933608091 0.0041474558664058 -0.522572976947842 4.41162314947416e-11 mirMAP -0.118834281338581 0.000701729269418148 NA NA NA hsa-miR-450a-5p FBXW11 1.74695686398479 4.62583996044297e-22 -0.522572976947842 4.41162314947416e-11 miRNAWalker2_validate -0.140707191685803 8.97461750691927e-15 NA NA NA hsa-miR-450b-5p FBXW11 1.25529820885833 1.18847120528666e-15 -0.522572976947842 4.41162314947416e-11 mirMAP -0.121821112095609 1.54398186365388e-08 NA NA NA hsa-miR-454-3p FBXW11 1.54137391927201 4.15861570449376e-20 -0.522572976947842 4.41162314947416e-11 MirTarget -0.138730446024612 2.18382017884097e-12 NA NA NA hsa-miR-505-3p FBXW11 0.912823669571645 4.0549774967148e-13 -0.522572976947842 4.41162314947416e-11 mirMAP -0.148076424279681 4.55606746874584e-08 NA NA NA hsa-miR-664a-3p FBXW11 -0.256108763664991 0.0513188660751664 -0.522572976947842 4.41162314947416e-11 mirMAP -0.101393949326574 0.000147998855741962 NA NA NA hsa-miR-93-5p FBXW11 1.61042951896619 5.1280369606967e-24 -0.522572976947842 4.41162314947416e-11 miRNATAP -0.148862160221229 5.23860983466119e-13 NA NA NA hsa-miR-96-5p FBXW11 1.42326703011157 4.39736150032373e-14 -0.522572976947842 4.41162314947416e-11 MirTarget;TargetScan;miRNATAP -0.128997421861498 3.86315690804369e-13 NA NA NA hsa-miR-15b-5p FOSL1 0.85315666454713 3.79816274836297e-12 0.684272564554175 0.0055525398984272 miRNATAP -0.270168644236004 0.00173154812271026 NA NA NA hsa-miR-195-5p FOSL1 -1.8367376818177 6.9944883988895e-31 0.684272564554175 0.0055525398984272 miRNATAP -0.314038887194874 7.30349560732251e-07 26337460 MicroRNA 195 5p a new regulator of Fra 1 suppresses the migration and invasion of prostate cancer cells; In addition we identified Fra-1 a cell motility regulator as a novel target of miR-195; We also observed that inhibition of miR-195 or restoration of Fra-1 in miR-195-over-expressed prostate cancer cells partially reversed the suppressive effects of miR-195 motility prostate cancer hsa-miR-326 FOSL1 -0.425943992128769 0.0415010315530797 0.684272564554175 0.0055525398984272 miRanda -0.164156522592857 0.0014984629249107 NA NA NA hsa-miR-34a-5p FOSL1 -0.117372471043915 0.364001947180738 0.684272564554175 0.0055525398984272 miRNAWalker2_validate;miRTarBase -0.450901648975182 5.48585144392116e-08 22198213;23001043 MicroRNA 34a inhibits migration and invasion of colon cancer cells via targeting to Fra 1; Here we identified Fra-1 as a new target of miR-34a and demonstrated that miR-34a inhibits Fra-1 expression at both protein and messenger RNA levels; Overexpression of miR-34a strongly inhibited colon cancer cell migration and invasion which can be partially rescued by forced expression of the Fra-1 transcript lacking the 3'-untranslated region;Moreover significant downregulation of miR-34a in metastatic breast cancer tissues was found to be inversely correlated with Fra-1 expression; Our results demonstrate that miR-34a/c functions as a metastasis suppressor to regulate breast cancer migration and invasion through targeting Fra-1 oncogene and suggest a therapeutic application of miR-34 in breast cancer cell migration;metastasis colon cancer;breast cancer hsa-miR-744-5p FRAT1 0.436098372735845 0.000850400989351181 -0.498793195674793 0.000155279375973943 miRNAWalker2_validate -0.130783673978729 0.0030531537454599 NA NA NA hsa-miR-22-3p FRAT2 0.00776313533473072 0.926356548861307 -0.286726511898642 0.029316879013789 miRNAWalker2_validate;MirTarget;miRNATAP -0.415818143070844 1.2420012708723e-09 NA NA NA hsa-miR-148b-5p FZD1 1.1533193737265 7.26420964688337e-13 0.202370822663888 0.202574353586073 MirTarget -0.22229623865695 1.40805789378432e-07 NA NA NA hsa-miR-186-5p FZD1 0.353452958261612 0.000145058448579496 0.202370822663888 0.202574353586073 mirMAP -0.443819315869232 1.78337309659339e-09 NA NA NA hsa-miR-192-5p FZD1 0.380924502586635 0.00986961967409205 0.202370822663888 0.202574353586073 miRNAWalker2_validate -0.17849780873765 0.000133115118940476 NA NA NA hsa-miR-200a-5p FZD1 0.701063526850019 0.000188402923774663 0.202370822663888 0.202574353586073 MirTarget -0.154567543120868 2.24969270904799e-05 NA NA NA hsa-miR-200b-5p FZD1 0.02621402664548 0.883725338810228 0.202370822663888 0.202574353586073 MirTarget -0.117979067492686 0.002253938989083 NA NA NA hsa-miR-205-3p FZD1 1.2960640797621 5.80786479909147e-11 0.202370822663888 0.202574353586073 mirMAP -0.221578243093832 4.89540221644546e-11 NA NA NA hsa-miR-29b-3p FZD1 -0.110721443686039 0.511264554091106 0.202370822663888 0.202574353586073 mirMAP -0.34391864667725 5.97933489498062e-18 NA NA NA hsa-miR-590-3p FZD1 0.221436901462551 0.0965904764063157 0.202370822663888 0.202574353586073 miRanda -0.24179842471756 2.96465190140345e-06 NA NA NA hsa-miR-944 FZD1 1.47323925060177 2.61626403984929e-13 0.202370822663888 0.202574353586073 mirMAP -0.102262312196088 0.00225405667409644 NA NA NA hsa-miR-15a-5p FZD10 0.783550182002274 2.60699595655907e-11 -0.311388129314746 0.219758577435407 miRNATAP -0.399132547382322 1.52329328716641e-05 NA NA NA hsa-miR-16-5p FZD10 0.521122945828175 1.40561786410572e-06 -0.311388129314746 0.219758577435407 miRNATAP -0.504383659194181 6.37712767675761e-07 NA NA NA hsa-miR-25-3p FZD10 0.76549796417801 3.32282098247097e-11 -0.311388129314746 0.219758577435407 miRNATAP -0.285129466248301 0.00253280592864319 NA NA NA hsa-miR-424-5p FZD10 1.48125289532143 9.10372985713165e-19 -0.311388129314746 0.219758577435407 miRNATAP -0.186474334748627 0.0034494575160454 NA NA NA hsa-miR-92a-3p FZD10 0.994679542307232 1.32587679156217e-16 -0.311388129314746 0.219758577435407 miRNATAP -0.262412611999907 0.00338878419687546 NA NA NA hsa-let-7f-1-3p FZD3 0.700374242293247 8.65000484720084e-08 -0.405919645349345 0.0378194076500925 MirTarget -0.234023009350349 0.000282322991762875 NA NA NA hsa-miR-106a-5p FZD3 0.67978010057847 0.00221925869726092 -0.405919645349345 0.0378194076500925 MirTarget;mirMAP;miRNATAP -0.11153753957119 0.00350111403434414 NA NA NA hsa-miR-142-3p FZD3 1.12754191614028 1.68798138028946e-08 -0.405919645349345 0.0378194076500925 miRanda -0.118512459580298 0.00483181300209284 NA NA NA hsa-miR-16-1-3p FZD3 0.955017760172879 5.95379292601146e-11 -0.405919645349345 0.0378194076500925 mirMAP -0.249215789471788 1.35563257853051e-05 NA NA NA hsa-miR-16-2-3p FZD3 1.1567130855258 1.01867256952189e-14 -0.405919645349345 0.0378194076500925 mirMAP -0.252327663922905 5.00557133337908e-06 NA NA NA hsa-miR-205-3p FZD3 1.2960640797621 5.80786479909147e-11 -0.405919645349345 0.0378194076500925 mirMAP -0.234932332851844 1.87444284032962e-08 25521201 Our data analysis also showed that miR-98 and miR-205 have two common predicted target genes FZD3 and RPS6KA3 which are actually genes associated with carcinoma according to the Online Mendelian Inheritance in Man OMIM database lung squamous cell cancer hsa-miR-205-5p FZD3 1.50759485376634 2.0003886738248e-16 -0.405919645349345 0.0378194076500925 MirTarget -0.250329887012726 1.99316269276153e-08 25521201 Our data analysis also showed that miR-98 and miR-205 have two common predicted target genes FZD3 and RPS6KA3 which are actually genes associated with carcinoma according to the Online Mendelian Inheritance in Man OMIM database lung squamous cell cancer hsa-miR-23a-3p FZD3 0.348231698801568 6.4911858506572e-05 -0.405919645349345 0.0378194076500925 MirTarget -0.371620292894839 0.000153714061322858 NA NA NA hsa-miR-23b-3p FZD3 -0.497563803223134 3.31483353357535e-05 -0.405919645349345 0.0378194076500925 MirTarget -0.269703040063802 0.000138913067017737 NA NA NA hsa-miR-27a-3p FZD3 0.348456440505425 0.00126682892514312 -0.405919645349345 0.0378194076500925 miRNATAP -0.34637741158127 1.08606674868051e-05 NA NA NA hsa-miR-27b-3p FZD3 -0.732682718863563 2.26896143573324e-09 -0.405919645349345 0.0378194076500925 miRNATAP -0.296138023529959 1.51707341048525e-05 NA NA NA hsa-miR-30e-3p FZD3 -0.890635378639789 1.65740480611339e-16 -0.405919645349345 0.0378194076500925 mirMAP -0.22355013875565 0.00371657463692107 NA NA NA hsa-let-7a-3p FZD4 0.0966652362351867 0.423761916840503 -0.815650187199159 4.38782163259962e-08 mirMAP -0.178911836594448 0.0010678781194651 NA NA NA hsa-let-7f-1-3p FZD4 0.700374242293247 8.65000484720084e-08 -0.815650187199159 4.38782163259962e-08 mirMAP -0.155969808971455 0.00173166560767719 NA NA NA hsa-let-7g-3p FZD4 0.637019243992294 0.000204623048574065 -0.815650187199159 4.38782163259962e-08 MirTarget;miRNATAP -0.130030558138227 0.00064027163524621 NA NA NA hsa-miR-106b-5p FZD4 0.50378717276868 1.45412404526866e-05 -0.815650187199159 4.38782163259962e-08 miRNATAP -0.233594020061164 3.26917089168384e-05 NA NA NA hsa-miR-130b-3p FZD4 1.44628430084411 9.13980959861273e-24 -0.815650187199159 4.38782163259962e-08 mirMAP -0.166771411710335 0.000130645962717094 NA NA NA hsa-miR-141-3p FZD4 0.730011517758706 0.000120338355004032 -0.815650187199159 4.38782163259962e-08 TargetScan -0.384621226441373 1.35952134171499e-32 NA NA NA hsa-miR-15a-5p FZD4 0.783550182002274 2.60699595655907e-11 -0.815650187199159 4.38782163259962e-08 MirTarget -0.316046540857295 6.61530653664161e-09 NA NA NA hsa-miR-15b-5p FZD4 0.85315666454713 3.79816274836297e-12 -0.815650187199159 4.38782163259962e-08 MirTarget -0.292039381468361 2.00521102059024e-08 NA NA NA hsa-miR-16-5p FZD4 0.521122945828175 1.40561786410572e-06 -0.815650187199159 4.38782163259962e-08 MirTarget -0.275961233079746 4.81081238426063e-06 NA NA NA hsa-miR-17-3p FZD4 -0.0127974722290336 0.909559935689875 -0.815650187199159 4.38782163259962e-08 MirTarget -0.269009081400882 4.18669539260405e-06 NA NA NA hsa-miR-17-5p FZD4 1.41924888736771 2.75805544953758e-18 -0.815650187199159 4.38782163259962e-08 TargetScan -0.369785561579625 5.57763418816234e-23 NA NA NA hsa-miR-185-5p FZD4 0.675225177054909 1.84953949190805e-13 -0.815650187199159 4.38782163259962e-08 MirTarget -0.213487766584419 0.00252870771975344 NA NA NA hsa-miR-200b-3p FZD4 0.0717138787925347 0.682858087587209 -0.815650187199159 4.38782163259962e-08 mirMAP -0.359330121493523 1.53241321540023e-23 NA NA NA hsa-miR-200c-3p FZD4 0.630251054099546 0.000131975031451555 -0.815650187199159 4.38782163259962e-08 mirMAP -0.391980669668059 4.43258549593976e-25 NA NA NA hsa-miR-20a-5p FZD4 1.1531986665452 1.02385132917958e-11 -0.815650187199159 4.38782163259962e-08 miRNATAP -0.333852681330871 9.51317386353706e-20 NA NA NA hsa-miR-21-5p FZD4 1.62465922021121 3.44191300985109e-58 -0.815650187199159 4.38782163259962e-08 mirMAP -0.287661271779748 6.60748558454114e-07 NA NA NA hsa-miR-224-3p FZD4 0.502645536188015 0.0081142387260641 -0.815650187199159 4.38782163259962e-08 MirTarget -0.24610422416118 5.21862603114631e-13 NA NA NA hsa-miR-25-3p FZD4 0.76549796417801 3.32282098247097e-11 -0.815650187199159 4.38782163259962e-08 mirMAP -0.22599947502801 5.38335232176849e-05 NA NA NA hsa-miR-27a-3p FZD4 0.348456440505425 0.00126682892514312 -0.815650187199159 4.38782163259962e-08 miRNATAP -0.25207980206607 3.36726990710064e-05 NA NA NA hsa-miR-301a-3p FZD4 2.14132004241926 4.46255413526808e-25 -0.815650187199159 4.38782163259962e-08 mirMAP -0.20080802333307 1.3516795151641e-11 NA NA NA hsa-miR-3065-3p FZD4 -0.543069092777161 0.0213164885178151 -0.815650187199159 4.38782163259962e-08 mirMAP -0.128490062173461 3.29880151819197e-06 NA NA NA hsa-miR-324-3p FZD4 0.867391246413545 3.63808540490361e-10 -0.815650187199159 4.38782163259962e-08 miRNATAP -0.219209977745863 2.46064329404204e-06 NA NA NA hsa-miR-33a-3p FZD4 0.20371038027126 0.212335697664505 -0.815650187199159 4.38782163259962e-08 mirMAP -0.186409384691855 4.5780850129921e-06 NA NA NA hsa-miR-3934-5p FZD4 1.48601805685912 2.33872147099905e-17 -0.815650187199159 4.38782163259962e-08 mirMAP -0.210225659786697 1.94482095129054e-08 NA NA NA hsa-miR-429 FZD4 0.559451508722375 0.00563641638673083 -0.815650187199159 4.38782163259962e-08 mirMAP -0.31150784766142 1.12702682090752e-23 NA NA NA hsa-miR-452-5p FZD4 0.373288744398455 0.0348485937209964 -0.815650187199159 4.38782163259962e-08 miRNATAP -0.213842960151609 5.64707690350463e-09 NA NA NA hsa-miR-454-3p FZD4 1.54137391927201 4.15861570449376e-20 -0.815650187199159 4.38782163259962e-08 mirMAP -0.232233065555925 4.20909041882496e-10 NA NA NA hsa-miR-455-3p FZD4 2.68574446868387 4.28975903022818e-42 -0.815650187199159 4.38782163259962e-08 mirMAP -0.192283917018249 1.70384213598465e-10 NA NA NA hsa-miR-484 FZD4 0.918280909791707 1.39168306854263e-14 -0.815650187199159 4.38782163259962e-08 PITA -0.264573659753093 7.66896801931238e-07 NA NA NA hsa-miR-505-5p FZD4 1.25888458076414 7.80089782306577e-13 -0.815650187199159 4.38782163259962e-08 MirTarget -0.108971904868985 0.00288728768052822 NA NA NA hsa-miR-576-5p FZD4 0.940432050128373 6.90227595663302e-12 -0.815650187199159 4.38782163259962e-08 mirMAP -0.286203264705305 7.16334363231192e-10 NA NA NA hsa-miR-589-3p FZD4 1.59559692667315 6.2886410639161e-15 -0.815650187199159 4.38782163259962e-08 mirMAP -0.226897440559596 1.16405890096401e-12 NA NA NA hsa-miR-590-3p FZD4 0.221436901462551 0.0965904764063157 -0.815650187199159 4.38782163259962e-08 miRanda;mirMAP;miRNATAP -0.128296051181024 0.00961747396970288 NA NA NA hsa-miR-590-5p FZD4 0.763025362395968 3.65305892505623e-09 -0.815650187199159 4.38782163259962e-08 mirMAP -0.33154840046641 1.90546523558682e-11 NA NA NA hsa-miR-629-3p FZD4 1.43262037314105 2.37092217984413e-19 -0.815650187199159 4.38782163259962e-08 miRNATAP -0.287336138379953 1.7789542370721e-13 NA NA NA hsa-miR-7-1-3p FZD4 1.13646121619622 1.49823237535933e-14 -0.815650187199159 4.38782163259962e-08 mirMAP -0.261549659988853 9.9088642742581e-10 NA NA NA hsa-miR-708-5p FZD4 1.54207894190626 2.2887257992285e-19 -0.815650187199159 4.38782163259962e-08 miRNATAP -0.204286200127646 2.38415454136822e-08 NA NA NA hsa-miR-92a-3p FZD4 0.994679542307232 1.32587679156217e-16 -0.815650187199159 4.38782163259962e-08 mirMAP -0.483540442305307 4.09293149289207e-21 NA NA NA hsa-miR-92b-3p FZD4 0.869628761112414 4.71129204795212e-09 -0.815650187199159 4.38782163259962e-08 mirMAP -0.141432953081511 0.00120039067478519 NA NA NA hsa-miR-940 FZD4 1.25303020594374 1.3005368359451e-10 -0.815650187199159 4.38782163259962e-08 miRNATAP -0.133815372372196 6.15164071025313e-05 NA NA NA hsa-miR-181a-2-3p FZD5 0.562132917934234 4.79313448225408e-05 -0.113485274622058 0.38590839547131 MirTarget -0.137692651649623 0.000777895527397809 NA NA NA hsa-miR-342-3p FZD5 0.99756868977753 9.28499866272332e-10 -0.113485274622058 0.38590839547131 PITA -0.114901171450085 0.000824922073740606 NA NA NA hsa-miR-369-3p FZD5 -1.2344419076994 2.66882944171146e-10 -0.113485274622058 0.38590839547131 MirTarget;PITA;miRNATAP -0.105032298373984 0.000244351098480649 NA NA NA hsa-miR-450b-5p FZD5 1.25529820885833 1.18847120528666e-15 -0.113485274622058 0.38590839547131 mirMAP -0.13961282239578 7.30218163652166e-05 NA NA NA hsa-miR-493-5p FZD5 -0.471586962917071 0.0221327433064002 -0.113485274622058 0.38590839547131 mirMAP -0.111501993784366 5.09909078182716e-05 NA NA NA hsa-miR-101-3p FZD6 -1.91263766544878 1.50270129259053e-39 0.959175728902371 7.16805044883792e-13 miRNAWalker2_validate;MirTarget -0.15236794370636 5.56147635006984e-05 NA NA NA hsa-miR-126-5p FZD6 -0.953529188793816 7.91719143295591e-16 0.959175728902371 7.16805044883792e-13 mirMAP;miRNATAP -0.18749347678421 0.000128934224548739 NA NA NA hsa-miR-139-5p FZD6 -1.46099200329485 7.85040381494472e-22 0.959175728902371 7.16805044883792e-13 miRanda -0.19666705958835 1.2956861634286e-07 NA NA NA hsa-miR-140-5p FZD6 -0.412389003031485 0.000136051708543369 0.959175728902371 7.16805044883792e-13 MirTarget;miRanda -0.299365048378534 4.2620559545244e-08 NA NA NA hsa-miR-19b-3p FZD6 0.538732279378089 0.000622008277870679 0.959175728902371 7.16805044883792e-13 MirTarget -0.119824221585792 0.00147978769330953 NA NA NA hsa-miR-142-3p FZD7 1.12754191614028 1.68798138028946e-08 -0.39549792326766 0.0891510942286115 miRanda -0.293214473864062 2.91121980676646e-09 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7; In addition we demonstrated that FZD7 was a direct target of miR-142-3p by dual luciferase assay and Western blot analysis; Overexpression of FZD7 expression was able to reverse the inhibitory effects induced by miR-142-3p cervical and endocervical cancer hsa-miR-142-5p FZD7 0.288897753038094 0.0900009317815725 -0.39549792326766 0.0891510942286115 MirTarget;PITA;miRNATAP -0.365085958937664 5.02394453662511e-10 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7 cervical and endocervical cancer hsa-miR-186-5p FZD7 0.353452958261612 0.000145058448579496 -0.39549792326766 0.0891510942286115 mirMAP -0.493097846846011 6.08851454307689e-06 NA NA NA hsa-miR-2355-5p FZD7 1.47205546931107 8.65192179636668e-19 -0.39549792326766 0.0891510942286115 MirTarget -0.420687622019341 2.978876488152e-13 NA NA NA hsa-miR-27a-3p FZD7 0.348456440505425 0.00126682892514312 -0.39549792326766 0.0891510942286115 MirTarget;miRNATAP -0.276163308720676 0.00335875166347624 24018051 Moreover up-regulation of miR-27a did not decrease the FZD7 mRNA level but significantly reduce its protein expression in BEL/5-FU cells; It was also confirmed that reduction of FZD7 by RNA interference induced inhibitory effects on the expression of MDR1/P-glycoprotein and β-catenin similar to miR-27a liver cancer hsa-miR-338-3p FZD7 -0.948755228846395 8.99167125682392e-08 -0.39549792326766 0.0891510942286115 miRanda -0.294907171125007 1.36247903183051e-07 NA NA NA hsa-miR-486-5p FZD7 -1.70341092285685 6.64232609099498e-14 -0.39549792326766 0.0891510942286115 miRanda -0.122880076472061 0.00470368943387573 NA NA NA hsa-miR-590-3p FZD7 0.221436901462551 0.0965904764063157 -0.39549792326766 0.0891510942286115 miRanda -0.211484945411416 0.00564246232477888 NA NA NA hsa-miR-324-5p FZD8 1.66709479707179 1.45961450445769e-23 -0.204293317181818 0.303884935891493 miRanda -0.162530099857064 0.00104845391384164 NA NA NA hsa-miR-146b-5p GSK3B 0.917975986853978 3.33749259316025e-09 0.343238217842623 0.000162620715851218 miRanda -0.132473733778903 1.22425435698654e-07 NA NA NA hsa-miR-155-5p GSK3B 0.533437622040649 0.00248671179205372 0.343238217842623 0.000162620715851218 miRNAWalker2_validate;miRNATAP -0.129703405382586 5.34297193283262e-09 NA NA NA hsa-miR-181a-5p GSK3B 0.819060835827404 1.38616688310277e-13 0.343238217842623 0.000162620715851218 mirMAP -0.129983989338606 0.00022139654686707 NA NA NA hsa-miR-181c-5p GSK3B -0.168991199007857 0.196949106150297 0.343238217842623 0.000162620715851218 mirMAP -0.100996413243857 0.000916035275097975 NA NA NA hsa-miR-19b-3p GSK3B 0.538732279378089 0.000622008277870679 0.343238217842623 0.000162620715851218 mirMAP -0.150537422390616 1.39629849063498e-09 NA NA NA hsa-miR-26b-5p GSK3B -0.254478038884324 0.0285227763044636 0.343238217842623 0.000162620715851218 miRNATAP -0.183171373213342 7.56842885965509e-08 NA NA NA hsa-miR-29b-3p GSK3B -0.110721443686039 0.511264554091106 0.343238217842623 0.000162620715851218 miRTarBase;miRNATAP -0.15553953034104 2.18389788804596e-11 NA NA NA hsa-miR-30d-3p GSK3B -0.577371911152798 2.02950840095287e-06 0.343238217842623 0.000162620715851218 miRNATAP -0.131426620771029 5.32900605744827e-05 NA NA NA hsa-miR-320a GSK3B 0.801356001806321 4.91397101474502e-09 0.343238217842623 0.000162620715851218 miRanda;mirMAP -0.118878412659656 3.17737768709188e-05 NA NA NA hsa-miR-342-3p GSK3B 0.99756868977753 9.28499866272332e-10 0.343238217842623 0.000162620715851218 miRanda -0.148362741070108 3.75779017463144e-10 NA NA NA hsa-miR-362-5p GSK3B 0.41089772861323 0.0404254902071382 0.343238217842623 0.000162620715851218 miRNATAP -0.127816847863223 5.47709912360141e-11 NA NA NA hsa-miR-374a-5p GSK3B -0.621903385111545 6.61791773205282e-12 0.343238217842623 0.000162620715851218 mirMAP -0.147719372342419 0.000672011632138884 NA NA NA hsa-miR-374b-5p GSK3B -0.288413933608091 0.0041474558664058 0.343238217842623 0.000162620715851218 mirMAP -0.228003781574329 6.67084161350237e-09 NA NA NA hsa-miR-664a-3p GSK3B -0.256108763664991 0.0513188660751664 0.343238217842623 0.000162620715851218 mirMAP -0.163651290979419 5.20958641528547e-08 NA NA NA hsa-miR-149-5p JUN 0.443278770827687 0.0642022866136881 -0.406452458333556 0.00529454262070968 miRNAWalker2_validate;miRNATAP -0.13798147635329 1.52011589067818e-07 NA NA NA hsa-miR-16-5p JUN 0.521122945828175 1.40561786410572e-06 -0.406452458333556 0.00529454262070968 miRNAWalker2_validate -0.156896269424296 0.00762361936521659 NA NA NA hsa-miR-200b-3p JUN 0.0717138787925347 0.682858087587209 -0.406452458333556 0.00529454262070968 MirTarget;TargetScan -0.1505246140756 3.14972638592719e-05 NA NA NA hsa-miR-200c-3p JUN 0.630251054099546 0.000131975031451555 -0.406452458333556 0.00529454262070968 MirTarget -0.149132086953986 9.85741819973546e-05 NA NA NA hsa-miR-3917 JUN 0.881206418103063 1.02921825829718e-05 -0.406452458333556 0.00529454262070968 MirTarget -0.138885380502224 2.55553984021909e-05 NA NA NA hsa-miR-429 JUN 0.559451508722375 0.00563641638673083 -0.406452458333556 0.00529454262070968 MirTarget;PITA;miRanda;miRNATAP -0.127337260989549 4.67151021689913e-05 NA NA NA hsa-miR-92a-3p JUN 0.994679542307232 1.32587679156217e-16 -0.406452458333556 0.00529454262070968 miRNATAP -0.22222740352937 1.47904297910557e-05 NA NA NA hsa-miR-93-5p JUN 1.61042951896619 5.1280369606967e-24 -0.406452458333556 0.00529454262070968 miRNAWalker2_validate -0.163687155850785 1.63570130702134e-05 NA NA NA hsa-miR-940 JUN 1.25303020594374 1.3005368359451e-10 -0.406452458333556 0.00529454262070968 MirTarget;PITA;miRNATAP -0.11176871246434 0.000559179228679763 NA NA NA hsa-let-7a-3p LEF1 0.0966652362351867 0.423761916840503 0.488266783568626 0.0110933059149055 miRNATAP -0.275840196352323 7.4673475039569e-05 NA NA NA hsa-miR-193b-3p LEF1 1.72788400801602 3.0722151264559e-21 0.488266783568626 0.0110933059149055 miRNAWalker2_validate -0.311745236740014 5.46005978515826e-13 NA NA NA hsa-miR-455-5p LEF1 1.408595672323 5.52039116456697e-22 0.488266783568626 0.0110933059149055 miRanda -0.211162394314959 0.000123308773316749 NA NA NA hsa-let-7a-3p LRP6 0.0966652362351867 0.423761916840503 -0.290768633611855 0.028504601744254 miRNATAP -0.172696061804567 0.000327731474978164 NA NA NA hsa-miR-15a-5p LRP6 0.783550182002274 2.60699595655907e-11 -0.290768633611855 0.028504601744254 miRNATAP -0.246252476987156 3.10489467850712e-07 NA NA NA hsa-miR-16-1-3p LRP6 0.955017760172879 5.95379292601146e-11 -0.290768633611855 0.028504601744254 mirMAP -0.117882237565804 0.00254559546988812 NA NA NA hsa-miR-17-5p LRP6 1.41924888736771 2.75805544953758e-18 -0.290768633611855 0.028504601744254 mirMAP -0.103895276410459 0.00250590672151827 NA NA NA hsa-miR-181b-5p LRP6 0.974255518824355 2.64876280203475e-16 -0.290768633611855 0.028504601744254 mirMAP -0.179053000512696 0.000152648651925039 NA NA NA hsa-miR-193a-3p LRP6 0.22120710726779 0.111827069464729 -0.290768633611855 0.028504601744254 miRanda -0.287874906789955 1.97223104419692e-12 NA NA NA hsa-miR-205-5p LRP6 1.50759485376634 2.0003886738248e-16 -0.290768633611855 0.028504601744254 miRNATAP -0.145594801152127 1.66998207714728e-06 NA NA NA hsa-miR-20a-5p LRP6 1.1531986665452 1.02385132917958e-11 -0.290768633611855 0.028504601744254 mirMAP -0.110649720101167 0.000930741415181488 NA NA NA hsa-miR-221-3p LRP6 0.410625614724387 0.000741090075261272 -0.290768633611855 0.028504601744254 miRNAWalker2_validate -0.25259899775257 8.31111143771914e-08 NA NA NA hsa-miR-29b-3p LRP6 -0.110721443686039 0.511264554091106 -0.290768633611855 0.028504601744254 miRNATAP -0.183504430388627 7.12130776666089e-08 NA NA NA hsa-miR-424-5p LRP6 1.48125289532143 9.10372985713165e-19 -0.290768633611855 0.028504601744254 miRNATAP -0.136935141042129 3.78976076486685e-05 NA NA NA hsa-miR-500a-5p LRP6 0.675401699376111 8.24389004707854e-05 -0.290768633611855 0.028504601744254 mirMAP -0.127165794972024 0.000143823434518489 NA NA NA hsa-miR-671-5p LRP6 1.90920358947989 6.8158317757852e-31 -0.290768633611855 0.028504601744254 PITA -0.135615652298569 3.6412797883649e-05 NA NA NA hsa-miR-34a-5p MAP3K7 -0.117372471043915 0.364001947180738 0.156076953982623 0.0290717069126645 miRNAWalker2_validate -0.131051914210823 4.05863054241424e-08 NA NA NA hsa-miR-374a-5p MAP3K7 -0.621903385111545 6.61791773205282e-12 0.156076953982623 0.0290717069126645 mirMAP -0.108854397484665 0.00133067551793497 NA NA NA hsa-miR-374b-5p MAP3K7 -0.288413933608091 0.0041474558664058 0.156076953982623 0.0290717069126645 mirMAP -0.123352040948618 6.70833151697066e-05 NA NA NA hsa-miR-664a-3p MAP3K7 -0.256108763664991 0.0513188660751664 0.156076953982623 0.0290717069126645 MirTarget;mirMAP -0.124053258642684 1.26589173107656e-07 NA NA NA hsa-miR-130a-3p MAPK10 0.67051191119964 4.89747518735144e-06 -0.515911722339727 0.0831884442739904 miRNATAP -0.257567155860406 0.00339348902810216 NA NA NA hsa-miR-146b-5p MAPK10 0.917975986853978 3.33749259316025e-09 -0.515911722339727 0.0831884442739904 miRanda -0.295681226115733 0.000329641658393179 NA NA NA hsa-miR-193a-3p MAPK10 0.22120710726779 0.111827069464729 -0.515911722339727 0.0831884442739904 miRanda;miRNATAP -0.493948546424074 1.00271078231064e-07 NA NA NA hsa-miR-222-3p MAPK10 1.08197052578759 2.32604040301699e-14 -0.515911722339727 0.0831884442739904 miRNATAP -0.276859620137527 0.00195454932101181 NA NA NA hsa-miR-450b-5p MAPK10 1.25529820885833 1.18847120528666e-15 -0.515911722339727 0.0831884442739904 mirMAP -0.280454869207043 0.000487914265247545 NA NA NA hsa-miR-455-5p MAPK10 1.408595672323 5.52039116456697e-22 -0.515911722339727 0.0831884442739904 miRanda -0.266609539974593 0.00177277067425019 NA NA NA hsa-miR-125a-5p MAPK8 0.215366061934933 0.119550904549401 -0.172407388594656 0.268657395750659 miRNAWalker2_validate -0.143608044868371 0.00350932932688087 NA NA NA hsa-miR-193b-3p MAPK8 1.72788400801602 3.0722151264559e-21 -0.172407388594656 0.268657395750659 miRNAWalker2_validate -0.103541446629706 0.00369576960582702 NA NA NA hsa-miR-301a-3p MAPK8 2.14132004241926 4.46255413526808e-25 -0.172407388594656 0.268657395750659 mirMAP -0.112933118413377 0.000284581455563168 NA NA NA hsa-miR-30b-5p MAPK8 -0.400238605368173 0.00346540992719245 -0.172407388594656 0.268657395750659 mirMAP -0.138590879277345 0.00519075072579384 NA NA NA hsa-miR-30c-5p MAPK8 0.021222006155897 0.886366656528128 -0.172407388594656 0.268657395750659 mirMAP -0.20973489202979 4.16686473002559e-06 NA NA NA hsa-miR-454-3p MAPK8 1.54137391927201 4.15861570449376e-20 -0.172407388594656 0.268657395750659 mirMAP -0.192614648253284 6.15604470021583e-07 NA NA NA hsa-miR-361-5p MAPK9 0.0803683277369505 0.314043140368058 -0.132566719441631 0.0608210268784422 miRanda -0.133370328666221 0.000635857332285973 NA NA NA hsa-miR-126-3p MMP7 0.0487843863772834 0.730130847436008 2.22540871299152 1.97697109796538e-07 miRNAWalker2_validate -0.579632484798146 1.37672988896139e-05 NA NA NA hsa-miR-126-5p MMP7 -0.953529188793816 7.91719143295591e-16 2.22540871299152 1.97697109796538e-07 miRNAWalker2_validate -0.777565854678429 4.7471848615542e-07 NA NA NA hsa-miR-590-5p MMP7 0.763025362395968 3.65305892505623e-09 2.22540871299152 1.97697109796538e-07 miRanda -0.412231117505389 0.00427894288779117 NA NA NA hsa-let-7c-5p MYC -2.07953368242668 3.46048888391218e-23 -0.32772106147221 0.0189770115533449 miRNAWalker2_validate;miRTarBase -0.107421906050131 0.000103545158346461 22128178 MicroRNA let 7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells prostate cancer hsa-miR-34a-5p MYC -0.117372471043915 0.364001947180738 -0.32772106147221 0.0189770115533449 miRNAWalker2_validate;miRTarBase -0.157674637324898 0.000854501792660625 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-103a-3p NFAT5 0.556219385347418 1.55815736455067e-09 -0.144057691414319 0.161686730526662 MirTarget -0.207995109133484 1.54357973740012e-05 NA NA NA hsa-miR-106b-5p NFAT5 0.50378717276868 1.45412404526866e-05 -0.144057691414319 0.161686730526662 MirTarget;miRNATAP -0.146943934885414 0.000126283712364061 NA NA NA hsa-miR-1301-3p NFAT5 2.13677668481885 6.11093268540831e-44 -0.144057691414319 0.161686730526662 MirTarget -0.129391396030477 1.05453785272728e-06 NA NA NA hsa-miR-130b-5p NFAT5 1.77265255049999 1.43627774829684e-29 -0.144057691414319 0.161686730526662 MirTarget;miRNATAP -0.104785785454191 9.48430079345845e-05 NA NA NA hsa-miR-148b-5p NFAT5 1.1533193737265 7.26420964688337e-13 -0.144057691414319 0.161686730526662 MirTarget -0.123399922340603 6.83148615366435e-06 NA NA NA hsa-miR-155-5p NFAT5 0.533437622040649 0.00248671179205372 -0.144057691414319 0.161686730526662 mirMAP;miRNATAP -0.106013680019205 2.59274713106684e-05 NA NA NA hsa-miR-15a-5p NFAT5 0.783550182002274 2.60699595655907e-11 -0.144057691414319 0.161686730526662 MirTarget -0.260711437036921 1.40373282155601e-12 NA NA NA hsa-miR-15b-5p NFAT5 0.85315666454713 3.79816274836297e-12 -0.144057691414319 0.161686730526662 MirTarget -0.177225037397607 6.14884064260808e-07 NA NA NA hsa-miR-16-1-3p NFAT5 0.955017760172879 5.95379292601146e-11 -0.144057691414319 0.161686730526662 mirMAP -0.148358705172954 7.56510988061617e-07 NA NA NA hsa-miR-16-5p NFAT5 0.521122945828175 1.40561786410572e-06 -0.144057691414319 0.161686730526662 MirTarget -0.150153488582548 0.000270995641402817 NA NA NA hsa-miR-17-3p NFAT5 -0.0127974722290336 0.909559935689875 -0.144057691414319 0.161686730526662 mirMAP -0.103995928874833 0.00945096554302533 NA NA NA hsa-miR-17-5p NFAT5 1.41924888736771 2.75805544953758e-18 -0.144057691414319 0.161686730526662 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.112871620600036 2.01129819909764e-05 NA NA NA hsa-miR-181a-5p NFAT5 0.819060835827404 1.38616688310277e-13 -0.144057691414319 0.161686730526662 MirTarget;miRNATAP -0.131376826355535 0.000922051779412021 NA NA NA hsa-miR-181c-5p NFAT5 -0.168991199007857 0.196949106150297 -0.144057691414319 0.161686730526662 MirTarget;miRNATAP -0.110282026210921 0.00129921261744019 NA NA NA hsa-miR-186-5p NFAT5 0.353452958261612 0.000145058448579496 -0.144057691414319 0.161686730526662 MirTarget;mirMAP -0.151512954738844 0.00172600664640523 NA NA NA hsa-miR-194-5p NFAT5 -0.0214221838459805 0.872940154118701 -0.144057691414319 0.161686730526662 miRNATAP -0.14212968386338 2.1091843578297e-05 NA NA NA hsa-miR-20a-5p NFAT5 1.1531986665452 1.02385132917958e-11 -0.144057691414319 0.161686730526662 MirTarget;miRNATAP -0.134471280444853 1.5833816699071e-07 NA NA NA hsa-miR-21-5p NFAT5 1.62465922021121 3.44191300985109e-58 -0.144057691414319 0.161686730526662 miRNAWalker2_validate;mirMAP -0.120531670517944 0.0023816899097577 NA NA NA hsa-miR-25-3p NFAT5 0.76549796417801 3.32282098247097e-11 -0.144057691414319 0.161686730526662 miRNATAP -0.237976661388013 2.67168726188591e-10 NA NA NA hsa-miR-27b-5p NFAT5 0.580870079022649 0.000181529223377382 -0.144057691414319 0.161686730526662 miRNATAP -0.102951916376891 0.000330247866781112 NA NA NA hsa-miR-29b-3p NFAT5 -0.110721443686039 0.511264554091106 -0.144057691414319 0.161686730526662 MirTarget;miRNATAP -0.141278373568308 8.22455022993091e-08 NA NA NA hsa-miR-30b-5p NFAT5 -0.400238605368173 0.00346540992719245 -0.144057691414319 0.161686730526662 MirTarget;miRNATAP -0.171140961776254 1.27520967589192e-07 NA NA NA hsa-miR-30c-5p NFAT5 0.021222006155897 0.886366656528128 -0.144057691414319 0.161686730526662 MirTarget;miRNATAP -0.156091609992667 1.91266697905943e-07 NA NA NA hsa-miR-32-5p NFAT5 -0.317310201890053 0.0102525324475293 -0.144057691414319 0.161686730526662 miRNATAP -0.118779663579516 0.00105899276601224 NA NA NA hsa-miR-320a NFAT5 0.801356001806321 4.91397101474502e-09 -0.144057691414319 0.161686730526662 mirMAP -0.132185235411107 3.94733879649678e-05 NA NA NA hsa-miR-361-3p NFAT5 0.272298288982435 0.0147874880476998 -0.144057691414319 0.161686730526662 MirTarget;PITA;miRNATAP -0.157839364118843 8.40063732907985e-05 NA NA NA hsa-miR-3613-5p NFAT5 0.410363235348614 0.00534956684590092 -0.144057691414319 0.161686730526662 miRNATAP -0.109936859621761 0.000285754269138999 NA NA NA hsa-miR-362-5p NFAT5 0.41089772861323 0.0404254902071382 -0.144057691414319 0.161686730526662 mirMAP -0.149775556522558 7.85100591328312e-12 NA NA NA hsa-miR-374a-3p NFAT5 -0.299190081500425 0.00682975596757891 -0.144057691414319 0.161686730526662 mirMAP -0.202521314928992 5.1250260182258e-07 NA NA NA hsa-miR-374b-5p NFAT5 -0.288413933608091 0.0041474558664058 -0.144057691414319 0.161686730526662 mirMAP;miRNATAP -0.20861924136137 2.7371658700598e-06 NA NA NA hsa-miR-500a-3p NFAT5 0.457959128173392 0.000691656736597067 -0.144057691414319 0.161686730526662 MirTarget -0.197462156544802 1.53996978062261e-09 NA NA NA hsa-miR-500a-5p NFAT5 0.675401699376111 8.24389004707854e-05 -0.144057691414319 0.161686730526662 mirMAP -0.106589909918206 3.71675813942985e-05 NA NA NA hsa-miR-576-5p NFAT5 0.940432050128373 6.90227595663302e-12 -0.144057691414319 0.161686730526662 MirTarget;PITA;mirMAP -0.101572775536991 0.0015236056581376 NA NA NA hsa-miR-582-3p NFAT5 -0.248056267546012 0.143798829508405 -0.144057691414319 0.161686730526662 MirTarget -0.10043084390206 0.00013622400612072 NA NA NA hsa-miR-582-5p NFAT5 -0.0366995972742474 0.821827119138923 -0.144057691414319 0.161686730526662 MirTarget;PITA;miRNATAP -0.107169405369745 9.40426162612886e-05 NA NA NA hsa-miR-590-5p NFAT5 0.763025362395968 3.65305892505623e-09 -0.144057691414319 0.161686730526662 PITA;mirMAP;miRNATAP -0.121823622273204 0.000359647472614924 NA NA NA hsa-miR-664a-3p NFAT5 -0.256108763664991 0.0513188660751664 -0.144057691414319 0.161686730526662 MirTarget -0.128060886298548 0.000171135382086359 NA NA NA hsa-miR-92a-3p NFAT5 0.994679542307232 1.32587679156217e-16 -0.144057691414319 0.161686730526662 miRNATAP -0.156770819510124 1.39123614451506e-05 NA NA NA hsa-miR-93-5p NFAT5 1.61042951896619 5.1280369606967e-24 -0.144057691414319 0.161686730526662 MirTarget;miRNATAP -0.156016318591379 3.97583367554973e-09 NA NA NA hsa-miR-130b-5p NFATC2 1.77265255049999 1.43627774829684e-29 -1.25486248564221 0.000172992176354394 MirTarget -0.514289720906144 3.45340671629822e-09 NA NA NA hsa-miR-16-2-3p NFATC2 1.1567130855258 1.01867256952189e-14 -1.25486248564221 0.000172992176354394 mirMAP -0.657909202427149 2.22088975341719e-12 NA NA NA hsa-miR-182-5p NFATC2 1.15060905311096 6.25565852529946e-10 -1.25486248564221 0.000172992176354394 mirMAP -0.547097191091464 5.39311037502917e-13 NA NA NA hsa-miR-186-5p NFATC2 0.353452958261612 0.000145058448579496 -1.25486248564221 0.000172992176354394 mirMAP -0.737589937834061 2.75639363716297e-06 NA NA NA hsa-miR-19a-3p NFATC2 1.35800152353624 2.80940447111944e-12 -1.25486248564221 0.000172992176354394 mirMAP -0.924100758885834 3.58487812401573e-42 NA NA NA hsa-miR-19b-3p NFATC2 0.538732279378089 0.000622008277870679 -1.25486248564221 0.000172992176354394 mirMAP -1.15509771675492 1.64102640977043e-41 NA NA NA hsa-miR-205-3p NFATC2 1.2960640797621 5.80786479909147e-11 -1.25486248564221 0.000172992176354394 mirMAP -0.343866501621686 1.8468695557269e-06 NA NA NA hsa-miR-222-3p NFATC2 1.08197052578759 2.32604040301699e-14 -1.25486248564221 0.000172992176354394 MirTarget -0.483064014402545 1.42535021555115e-06 NA NA NA hsa-miR-2355-3p NFATC2 1.58434563546762 4.06578912176206e-18 -1.25486248564221 0.000172992176354394 mirMAP -0.42812739127172 2.38490246638194e-08 NA NA NA hsa-miR-2355-5p NFATC2 1.47205546931107 8.65192179636668e-19 -1.25486248564221 0.000172992176354394 MirTarget -0.58837741374673 1.74879666791307e-12 NA NA NA hsa-miR-26b-3p NFATC2 0.421575313079363 0.00223298166810883 -1.25486248564221 0.000172992176354394 MirTarget -0.319217894210201 0.00264752852289272 NA NA NA hsa-miR-27b-5p NFATC2 0.580870079022649 0.000181529223377382 -1.25486248564221 0.000172992176354394 mirMAP -0.336293189286217 0.000339446551242512 NA NA NA hsa-miR-29a-5p NFATC2 0.323252792625584 0.0370417231222825 -1.25486248564221 0.000172992176354394 mirMAP;miRNATAP -0.544946324623055 5.46968828870313e-09 NA NA NA hsa-miR-30b-5p NFATC2 -0.400238605368173 0.00346540992719245 -1.25486248564221 0.000172992176354394 MirTarget;mirMAP -0.763262749165252 3.23713764040455e-13 NA NA NA hsa-miR-30c-5p NFATC2 0.021222006155897 0.886366656528128 -1.25486248564221 0.000172992176354394 MirTarget;mirMAP -0.819077629610369 1.45073885011096e-17 NA NA NA hsa-miR-31-3p NFATC2 2.10124531535908 1.70135756565194e-08 -1.25486248564221 0.000172992176354394 MirTarget -0.146949889334041 0.000140785099541377 NA NA NA hsa-miR-320a NFATC2 0.801356001806321 4.91397101474502e-09 -1.25486248564221 0.000172992176354394 MirTarget -0.59759720970056 1.06046391812254e-08 NA NA NA hsa-miR-320b NFATC2 1.23473838180754 3.04337566045537e-14 -1.25486248564221 0.000172992176354394 MirTarget -0.301551217089888 0.000590783452269324 NA NA NA hsa-miR-335-3p NFATC2 0.336785882180547 0.0542446207938138 -1.25486248564221 0.000172992176354394 mirMAP -0.294498129578907 0.000424975091200581 NA NA NA hsa-miR-33a-3p NFATC2 0.20371038027126 0.212335697664505 -1.25486248564221 0.000172992176354394 mirMAP -0.245013497318194 0.00723337082303761 NA NA NA hsa-miR-3607-3p NFATC2 1.01377165357363 9.13355519701165e-05 -1.25486248564221 0.000172992176354394 MirTarget;mirMAP -0.349460391273266 2.66876725963668e-10 NA NA NA hsa-miR-3613-5p NFATC2 0.410363235348614 0.00534956684590092 -1.25486248564221 0.000172992176354394 mirMAP -0.608571808652233 5.28086151872216e-10 NA NA NA hsa-miR-484 NFATC2 0.918280909791707 1.39168306854263e-14 -1.25486248564221 0.000172992176354394 MirTarget -0.479425009930687 6.21849237210953e-05 NA NA NA hsa-miR-7-1-3p NFATC2 1.13646121619622 1.49823237535933e-14 -1.25486248564221 0.000172992176354394 mirMAP -0.437536024803867 5.31776518083098e-06 NA NA NA hsa-miR-9-5p NFATC2 1.65694862043766 2.08325802567323e-05 -1.25486248564221 0.000172992176354394 MirTarget -0.188930767530834 3.12605846928591e-07 NA NA NA hsa-miR-15a-5p NFATC3 0.783550182002274 2.60699595655907e-11 -0.122429472123375 0.151542167625529 MirTarget;miRNATAP -0.23896463390166 3.19718683049365e-15 NA NA NA hsa-miR-29b-3p NFATC3 -0.110721443686039 0.511264554091106 -0.122429472123375 0.151542167625529 MirTarget;miRNATAP -0.16784148211833 5.77255843957477e-15 NA NA NA hsa-miR-30b-5p NFATC3 -0.400238605368173 0.00346540992719245 -0.122429472123375 0.151542167625529 MirTarget;miRNATAP -0.132557291878128 8.17457700322037e-07 NA NA NA hsa-miR-30c-5p NFATC3 0.021222006155897 0.886366656528128 -0.122429472123375 0.151542167625529 MirTarget;miRNATAP -0.119500911793098 1.55486386247615e-06 NA NA NA hsa-miR-339-5p NFATC3 1.07771430326938 2.45772601859307e-09 -0.122429472123375 0.151542167625529 miRanda -0.158684613876262 7.15220237478457e-16 NA NA NA hsa-miR-362-3p NFATC3 -0.697212068252854 2.61718493418184e-06 -0.122429472123375 0.151542167625529 miRanda -0.101516304611824 4.28696073128881e-05 NA NA NA hsa-miR-505-3p NFATC3 0.912823669571645 4.0549774967148e-13 -0.122429472123375 0.151542167625529 mirMAP -0.105028489202972 0.000269141405046069 NA NA NA hsa-miR-589-3p NFATC3 1.59559692667315 6.2886410639161e-15 -0.122429472123375 0.151542167625529 mirMAP -0.102849134107554 1.46704937520489e-08 NA NA NA hsa-miR-15b-3p NFATC4 1.05020782493504 6.38723677324836e-14 0.415879415068961 0.0231544563160674 mirMAP -0.308042115025679 2.37467711881828e-08 NA NA NA hsa-miR-193a-3p NFATC4 0.22120710726779 0.111827069464729 0.415879415068961 0.0231544563160674 miRanda -0.170575117609832 0.00306091588712347 NA NA NA hsa-miR-29a-3p NFATC4 -1.26881270980079 2.82496991513463e-22 0.415879415068961 0.0231544563160674 miRNATAP -0.159786866184639 0.00656637949012794 NA NA NA hsa-miR-429 NFATC4 0.559451508722375 0.00563641638673083 0.415879415068961 0.0231544563160674 miRNATAP -0.191470414872037 9.91379935744975e-07 NA NA NA hsa-miR-629-3p NFATC4 1.43262037314105 2.37092217984413e-19 0.415879415068961 0.0231544563160674 mirMAP -0.22273814727208 3.74632403524541e-06 NA NA NA hsa-miR-200b-3p NKD1 0.0717138787925347 0.682858087587209 0.725365278125643 0.00125463712045226 TargetScan -0.232568993512636 3.17464537813451e-05 NA NA NA hsa-miR-340-5p NKD1 -0.608415693437977 4.44345153563513e-05 0.725365278125643 0.00125463712045226 mirMAP -0.205337742152414 0.0017674712074584 NA NA NA hsa-miR-429 NKD1 0.559451508722375 0.00563641638673083 0.725365278125643 0.00125463712045226 miRanda;miRNATAP -0.131962362051135 0.00657248359023832 NA NA NA hsa-miR-125a-3p NKD2 0.116035800853173 0.444825559956959 1.51771103096878 3.08088713537078e-10 miRanda -0.202042368922688 0.00423806732897665 NA NA NA hsa-let-7a-5p NLK -0.439381775414001 3.1119785480023e-05 0.332302579249867 3.71291935203561e-07 TargetScan;miRNATAP -0.123649485141098 4.67770623394563e-06 NA NA NA hsa-let-7b-5p NLK -0.2489842756826 0.0211384499461719 0.332302579249867 3.71291935203561e-07 miRNATAP -0.115035305955481 1.46799264825039e-05 NA NA NA hsa-miR-106a-5p PLCB1 0.67978010057847 0.00221925869726092 -0.022524541753576 0.915040704598445 miRNATAP -0.145124543008846 0.000414772685699638 NA NA NA hsa-miR-130a-3p PLCB1 0.67051191119964 4.89747518735144e-06 -0.022524541753576 0.915040704598445 miRNATAP -0.308255321512659 5.95679595873923e-07 NA NA NA hsa-miR-142-3p PLCB1 1.12754191614028 1.68798138028946e-08 -0.022524541753576 0.915040704598445 PITA;miRanda;miRNATAP -0.237019217974072 1.31071205932609e-07 NA NA NA hsa-miR-16-2-3p PLCB1 1.1567130855258 1.01867256952189e-14 -0.022524541753576 0.915040704598445 mirMAP -0.384927346502793 6.77193777515327e-11 NA NA NA hsa-miR-17-5p PLCB1 1.41924888736771 2.75805544953758e-18 -0.022524541753576 0.915040704598445 TargetScan;miRNATAP -0.296798464915001 3.99887146017288e-08 NA NA NA hsa-miR-19a-3p PLCB1 1.35800152353624 2.80940447111944e-12 -0.022524541753576 0.915040704598445 miRNATAP -0.273200508438584 2.17407557212868e-09 NA NA NA hsa-miR-19b-3p PLCB1 0.538732279378089 0.000622008277870679 -0.022524541753576 0.915040704598445 miRNATAP -0.382088876690375 2.43104366906365e-11 NA NA NA hsa-miR-205-5p PLCB1 1.50759485376634 2.0003886738248e-16 -0.022524541753576 0.915040704598445 miRNATAP -0.301232176450551 3.20916378268651e-10 NA NA NA hsa-miR-20a-5p PLCB1 1.1531986665452 1.02385132917958e-11 -0.022524541753576 0.915040704598445 miRNATAP -0.310319514666889 3.36715897909662e-09 NA NA NA hsa-miR-26b-5p PLCB1 -0.254478038884324 0.0285227763044636 -0.022524541753576 0.915040704598445 miRNATAP -0.325308234176227 3.96530136649065e-05 NA NA NA hsa-miR-301a-3p PLCB1 2.14132004241926 4.46255413526808e-25 -0.022524541753576 0.915040704598445 miRNATAP -0.139748187424388 0.00092764726480929 NA NA NA hsa-miR-30c-5p PLCB1 0.021222006155897 0.886366656528128 -0.022524541753576 0.915040704598445 miRNAWalker2_validate -0.199990153525374 0.00126658841511169 NA NA NA hsa-miR-320a PLCB1 0.801356001806321 4.91397101474502e-09 -0.022524541753576 0.915040704598445 miRanda -0.175340530785379 0.00822364533569475 NA NA NA hsa-miR-34a-5p PLCB1 -0.117372471043915 0.364001947180738 -0.022524541753576 0.915040704598445 miRNATAP -0.212908741190281 0.00287116591133316 NA NA NA hsa-miR-454-3p PLCB1 1.54137391927201 4.15861570449376e-20 -0.022524541753576 0.915040704598445 miRNATAP -0.297461708658117 1.16016760776761e-08 NA NA NA hsa-miR-590-3p PLCB1 0.221436901462551 0.0965904764063157 -0.022524541753576 0.915040704598445 PITA;miRanda;mirMAP -0.226671734521442 0.00104255784616856 NA NA NA hsa-miR-590-5p PLCB1 0.763025362395968 3.65305892505623e-09 -0.022524541753576 0.915040704598445 PITA;miRanda -0.273081966502604 9.63549491711264e-05 NA NA NA hsa-miR-7-1-3p PLCB1 1.13646121619622 1.49823237535933e-14 -0.022524541753576 0.915040704598445 mirMAP -0.22970608819611 0.000146171008121588 NA NA NA hsa-miR-93-5p PLCB1 1.61042951896619 5.1280369606967e-24 -0.022524541753576 0.915040704598445 miRNATAP -0.202436888200631 0.000231763302709477 NA NA NA hsa-miR-193a-3p PLCB2 0.22120710726779 0.111827069464729 0.289286485889504 0.103156227738883 miRanda -0.224042510777498 5.5140250396673e-05 NA NA NA hsa-let-7a-3p PLCB4 0.0966652362351867 0.423761916840503 -1.79915690633647 3.55292686583561e-08 mirMAP;miRNATAP -0.404112140286357 0.000750895918311385 NA NA NA hsa-let-7f-1-3p PLCB4 0.700374242293247 8.65000484720084e-08 -1.79915690633647 3.55292686583561e-08 mirMAP -0.299647546936063 0.00612924228486001 NA NA NA hsa-miR-16-2-3p PLCB4 1.1567130855258 1.01867256952189e-14 -1.79915690633647 3.55292686583561e-08 mirMAP -0.49802107249936 9.03863307857627e-08 NA NA NA hsa-miR-23a-3p PLCB4 0.348231698801568 6.4911858506572e-05 -1.79915690633647 3.55292686583561e-08 miRNATAP -0.463238740647874 0.00543262966419115 NA NA NA hsa-miR-454-3p PLCB4 1.54137391927201 4.15861570449376e-20 -1.79915690633647 3.55292686583561e-08 miRNATAP -0.459826573216362 1.92944104782328e-08 NA NA NA hsa-miR-455-5p PLCB4 1.408595672323 5.52039116456697e-22 -1.79915690633647 3.55292686583561e-08 PITA;miRanda -0.72967361273504 2.83862102620001e-15 NA NA NA hsa-miR-944 PLCB4 1.47323925060177 2.61626403984929e-13 -1.79915690633647 3.55292686583561e-08 mirMAP -0.372684891643749 7.11725775074018e-08 NA NA NA hsa-miR-127-3p PPARD -1.47175957435172 9.8707469067377e-14 0.352387915634285 0.00541458870659813 miRanda -0.117502475777523 1.48164261644584e-05 NA NA NA hsa-miR-130b-3p PPARD 1.44628430084411 9.13980959861273e-24 0.352387915634285 0.00541458870659813 mirMAP -0.206512790573978 1.3495970976655e-08 NA NA NA hsa-miR-140-5p PPARD -0.412389003031485 0.000136051708543369 0.352387915634285 0.00541458870659813 miRanda -0.249302173781692 9.49269091872016e-07 NA NA NA hsa-miR-148a-3p PPARD -0.428944290834563 0.00954246923521465 0.352387915634285 0.00541458870659813 mirMAP -0.222028118966399 1.28148220939657e-11 NA NA NA hsa-miR-148b-3p PPARD 0.386859166050437 4.6728211830726e-06 0.352387915634285 0.00541458870659813 mirMAP -0.3532264966551 5.92905152120491e-08 NA NA NA hsa-miR-15b-5p PPARD 0.85315666454713 3.79816274836297e-12 0.352387915634285 0.00541458870659813 mirMAP -0.198177919054829 6.67495333035755e-06 NA NA NA hsa-miR-16-5p PPARD 0.521122945828175 1.40561786410572e-06 0.352387915634285 0.00541458870659813 mirMAP -0.193308952808848 0.000146436899101309 NA NA NA hsa-miR-195-5p PPARD -1.8367376818177 6.9944883988895e-31 0.352387915634285 0.00541458870659813 mirMAP -0.211004151536112 5.88444570736457e-11 NA NA NA hsa-miR-28-5p PPARD -0.026996999089909 0.733047113251652 0.352387915634285 0.00541458870659813 mirMAP -0.612260121856773 5.7246652760771e-19 NA NA NA hsa-miR-29a-3p PPARD -1.26881270980079 2.82496991513463e-22 0.352387915634285 0.00541458870659813 miRNATAP -0.153258862159855 0.000157056322758519 NA NA NA hsa-miR-29c-3p PPARD -2.08166260448948 8.3238369390898e-24 0.352387915634285 0.00541458870659813 miRNATAP -0.163886004261202 6.4333558702803e-11 NA NA NA hsa-miR-30b-3p PPARD -0.338530747940815 0.0223424741180399 0.352387915634285 0.00541458870659813 mirMAP -0.213317359206811 8.04933288917786e-09 NA NA NA hsa-miR-34a-5p PPARD -0.117372471043915 0.364001947180738 0.352387915634285 0.00541458870659813 mirMAP -0.321927222097746 1.68638685204601e-14 NA NA NA hsa-miR-423-5p PPARD 0.60141781325829 1.62940950644999e-07 0.352387915634285 0.00541458870659813 MirTarget;mirMAP -0.224495594362981 2.35154534589259e-06 NA NA NA hsa-miR-497-5p PPARD -0.966244470847844 5.26505649147857e-12 0.352387915634285 0.00541458870659813 mirMAP -0.282951964657101 8.15778630912902e-14 NA NA NA hsa-miR-625-3p PPARD 0.0858338965684338 0.484971431380441 0.352387915634285 0.00541458870659813 mirMAP -0.356296290492127 6.00369536435505e-16 NA NA NA hsa-miR-769-5p PPARD 0.0865819375213306 0.445395188017017 0.352387915634285 0.00541458870659813 mirMAP -0.354849732414977 1.4895963316724e-13 NA NA NA hsa-miR-9-5p PPARD 1.65694862043766 2.08325802567323e-05 0.352387915634285 0.00541458870659813 miRNATAP -0.11724352688001 7.78825620573896e-18 NA NA NA hsa-miR-664a-3p PPP2CA -0.256108763664991 0.0513188660751664 -0.157094072613604 0.0267322811415248 mirMAP -0.106852242976453 4.77000247252727e-06 NA NA NA hsa-miR-421 PPP2CB 0.945488088619653 2.35762398527362e-09 -0.476022792153769 4.06003367022085e-09 miRNAWalker2_validate;miRanda -0.112192501866666 3.84022796644551e-07 NA NA NA hsa-miR-15b-5p PPP2R1B 0.85315666454713 3.79816274836297e-12 -0.214632147370702 0.032287082704768 MirTarget -0.131544236138784 0.000158748224069463 NA NA NA hsa-miR-30b-5p PPP2R1B -0.400238605368173 0.00346540992719245 -0.214632147370702 0.032287082704768 miRNATAP -0.135040929585792 2.08942951526129e-05 NA NA NA hsa-miR-140-3p PPP2R5C -0.967453553824782 7.6999446305445e-23 -0.079739932974138 0.203093758954289 MirTarget -0.101657239125858 0.000127153182619392 NA NA NA hsa-miR-15a-5p PPP2R5C 0.783550182002274 2.60699595655907e-11 -0.079739932974138 0.203093758954289 miRNATAP -0.107559980888303 1.90647832582209e-06 NA NA NA hsa-miR-16-5p PPP2R5C 0.521122945828175 1.40561786410572e-06 -0.079739932974138 0.203093758954289 miRNAWalker2_validate;miRNATAP -0.121127644841362 1.0886078966924e-06 NA NA NA hsa-miR-28-3p PPP2R5C 0.459875450032895 3.47095927872566e-07 -0.079739932974138 0.203093758954289 PITA -0.115066147891396 0.000123615638667382 NA NA NA hsa-miR-101-5p PPP2R5E -1.429324744941 4.00032662184937e-18 0.180603227918551 0.0767872681161267 MirTarget -0.121796110333379 2.58193270399917e-06 NA NA NA hsa-miR-125a-5p PPP2R5E 0.215366061934933 0.119550904549401 0.180603227918551 0.0767872681161267 miRNAWalker2_validate -0.258631240828125 1.39238827572283e-16 NA NA NA hsa-miR-148b-5p PPP2R5E 1.1533193737265 7.26420964688337e-13 0.180603227918551 0.0767872681161267 MirTarget -0.102040127003136 0.000184550061310154 NA NA NA hsa-miR-16-2-3p PPP2R5E 1.1567130855258 1.01867256952189e-14 0.180603227918551 0.0767872681161267 mirMAP -0.110374696166335 0.000132085105125086 NA NA NA hsa-miR-181a-5p PPP2R5E 0.819060835827404 1.38616688310277e-13 0.180603227918551 0.0767872681161267 MirTarget;mirMAP -0.191742076509132 9.31441848437386e-07 NA NA NA hsa-miR-181c-5p PPP2R5E -0.168991199007857 0.196949106150297 0.180603227918551 0.0767872681161267 MirTarget;mirMAP -0.193178023621354 9.4099630242982e-09 NA NA NA hsa-miR-181d-5p PPP2R5E 0.367649966373544 0.00537300571455306 0.180603227918551 0.0767872681161267 MirTarget -0.180930186940803 5.64550764686304e-08 NA NA NA hsa-miR-195-3p PPP2R5E -0.624259620429699 0.000164279659144497 0.180603227918551 0.0767872681161267 mirMAP -0.115521563097818 1.49951403071768e-05 NA NA NA hsa-miR-19b-3p PPP2R5E 0.538732279378089 0.000622008277870679 0.180603227918551 0.0767872681161267 miRTarBase;MirTarget -0.139966608931062 5.23560102756024e-07 NA NA NA hsa-miR-217 PPP2R5E -1.35391381055929 2.42394951427902e-09 0.180603227918551 0.0767872681161267 MirTarget -0.123549403585123 6.7106028097879e-11 NA NA NA hsa-miR-29b-2-5p PPP2R5E -0.502720326849742 0.000730448246894952 0.180603227918551 0.0767872681161267 mirMAP -0.205380874921333 1.99345183535714e-12 NA NA NA hsa-miR-30a-3p PPP2R5E -2.26144364746452 8.12421214153823e-31 0.180603227918551 0.0767872681161267 MirTarget -0.103965856060049 8.87868744300167e-07 NA NA NA hsa-miR-30a-5p PPP2R5E -1.79779915425811 1.93360169837799e-26 0.180603227918551 0.0767872681161267 mirMAP -0.194859137906426 1.11619503683474e-15 NA NA NA hsa-miR-30b-5p PPP2R5E -0.400238605368173 0.00346540992719245 0.180603227918551 0.0767872681161267 mirMAP -0.256215189780032 4.77958615637712e-16 NA NA NA hsa-miR-30c-5p PPP2R5E 0.021222006155897 0.886366656528128 0.180603227918551 0.0767872681161267 mirMAP -0.266598706364208 3.13527407356585e-20 NA NA NA hsa-miR-30d-3p PPP2R5E -0.577371911152798 2.02950840095287e-06 0.180603227918551 0.0767872681161267 MirTarget -0.197811183281792 4.13821558112978e-08 NA NA NA hsa-miR-30d-5p PPP2R5E -0.38399848121878 0.000171129616944749 0.180603227918551 0.0767872681161267 mirMAP -0.167248295974402 0.000118757063755921 NA NA NA hsa-miR-30e-3p PPP2R5E -0.890635378639789 1.65740480611339e-16 0.180603227918551 0.0767872681161267 MirTarget -0.145120561430267 0.000289423915946692 NA NA NA hsa-miR-30e-5p PPP2R5E -1.02114836019762 6.81961221797866e-17 0.180603227918551 0.0767872681161267 mirMAP -0.17573392444008 5.36051234374019e-07 NA NA NA hsa-miR-342-3p PPP2R5E 0.99756868977753 9.28499866272332e-10 0.180603227918551 0.0767872681161267 miRanda -0.129489960673769 1.16112498158637e-06 NA NA NA hsa-miR-374a-3p PPP2R5E -0.299190081500425 0.00682975596757891 0.180603227918551 0.0767872681161267 MirTarget -0.198591202168382 6.94641610547591e-07 NA NA NA hsa-miR-374a-5p PPP2R5E -0.621903385111545 6.61791773205282e-12 0.180603227918551 0.0767872681161267 mirMAP -0.162868168428917 0.000782217007253097 NA NA NA hsa-miR-374b-5p PPP2R5E -0.288413933608091 0.0041474558664058 0.180603227918551 0.0767872681161267 mirMAP -0.324006756379648 8.60024893350953e-14 NA NA NA hsa-miR-454-3p PPP2R5E 1.54137391927201 4.15861570449376e-20 0.180603227918551 0.0767872681161267 mirMAP -0.11845766102066 2.87024261453076e-06 NA NA NA hsa-miR-500a-3p PPP2R5E 0.457959128173392 0.000691656736597067 0.180603227918551 0.0767872681161267 MirTarget -0.235973100578834 2.18727093013293e-13 NA NA NA hsa-miR-501-3p PPP2R5E 0.820141346319976 1.74562930463389e-08 0.180603227918551 0.0767872681161267 MirTarget;PITA;TargetScan;miRNATAP -0.123011816760259 4.29572126578338e-05 NA NA NA hsa-miR-576-5p PPP2R5E 0.940432050128373 6.90227595663302e-12 0.180603227918551 0.0767872681161267 mirMAP -0.112573510913937 0.000390545146947586 NA NA NA hsa-let-7g-5p PPP3CA -0.250780249469264 0.00939610188330072 0.0261166441094005 0.774380327390763 miRNATAP -0.129044274233211 0.00176768769369972 NA NA NA hsa-miR-17-5p PPP3CA 1.41924888736771 2.75805544953758e-18 0.0261166441094005 0.774380327390763 miRNATAP -0.107154786794133 4.49246161780872e-06 NA NA NA hsa-miR-186-5p PPP3CA 0.353452958261612 0.000145058448579496 0.0261166441094005 0.774380327390763 mirMAP -0.119442984122439 0.00521905941342711 NA NA NA hsa-miR-194-5p PPP3CA -0.0214221838459805 0.872940154118701 0.0261166441094005 0.774380327390763 MirTarget -0.227106380168213 4.11707254283389e-15 NA NA NA hsa-miR-20a-5p PPP3CA 1.1531986665452 1.02385132917958e-11 0.0261166441094005 0.774380327390763 miRNATAP -0.135937480891387 1.71175203332467e-09 NA NA NA hsa-miR-30c-5p PPP3CA 0.021222006155897 0.886366656528128 0.0261166441094005 0.774380327390763 miRNATAP -0.138568670147619 1.67033051966156e-07 NA NA NA hsa-miR-30d-5p PPP3CA -0.38399848121878 0.000171129616944749 0.0261166441094005 0.774380327390763 miRNATAP -0.103928901064269 0.00747324777039719 NA NA NA hsa-miR-361-3p PPP3CA 0.272298288982435 0.0147874880476998 0.0261166441094005 0.774380327390763 MirTarget;PITA;miRNATAP -0.147461540913571 3.1572107642519e-05 NA NA NA hsa-miR-590-3p PPP3CA 0.221436901462551 0.0965904764063157 0.0261166441094005 0.774380327390763 miRanda;mirMAP -0.1292662240092 1.28492091373993e-05 NA NA NA hsa-miR-590-5p PPP3CA 0.763025362395968 3.65305892505623e-09 0.0261166441094005 0.774380327390763 PITA;miRanda;miRNATAP -0.130608084993601 1.4121892378982e-05 NA NA NA hsa-miR-664a-3p PPP3CA -0.256108763664991 0.0513188660751664 0.0261166441094005 0.774380327390763 mirMAP -0.154862721187903 2.28408619679922e-07 NA NA NA hsa-miR-7-1-3p PPP3CA 1.13646121619622 1.49823237535933e-14 0.0261166441094005 0.774380327390763 MirTarget;mirMAP -0.113744929124115 1.18665245144482e-05 NA NA NA hsa-miR-93-5p PPP3CA 1.61042951896619 5.1280369606967e-24 0.0261166441094005 0.774380327390763 miRNATAP -0.134887598190219 8.69707313946358e-09 NA NA NA hsa-miR-96-5p PPP3CA 1.42326703011157 4.39736150032373e-14 0.0261166441094005 0.774380327390763 TargetScan -0.105360576077386 1.99204409171748e-07 NA NA NA hsa-miR-15b-5p PPP3CB 0.85315666454713 3.79816274836297e-12 -0.430650123435909 1.6653183674225e-09 miRNATAP -0.147896038786253 2.77153942258358e-09 NA NA NA hsa-miR-361-5p PPP3CB 0.0803683277369505 0.314043140368058 -0.430650123435909 1.6653183674225e-09 miRanda -0.146324240065503 0.000258725360624939 NA NA NA hsa-miR-429 PPP3CB 0.559451508722375 0.00563641638673083 -0.430650123435909 1.6653183674225e-09 miRanda -0.126839398598655 4.12587575752935e-17 NA NA NA hsa-miR-141-3p PRICKLE1 0.730011517758706 0.000120338355004032 0.0737328275797111 0.738753519259093 TargetScan -0.320619266132504 1.02794466988628e-10 NA NA NA hsa-miR-17-5p PRICKLE1 1.41924888736771 2.75805544953758e-18 0.0737328275797111 0.738753519259093 miRNAWalker2_validate -0.453790502995474 3.47838093815945e-16 NA NA NA hsa-miR-192-5p PRICKLE1 0.380924502586635 0.00986961967409205 0.0737328275797111 0.738753519259093 miRNAWalker2_validate -0.274707596339476 2.3248446196138e-05 NA NA NA hsa-miR-30b-5p PRICKLE1 -0.400238605368173 0.00346540992719245 0.0737328275797111 0.738753519259093 mirMAP -0.433947550168624 3.80099709322178e-10 NA NA NA hsa-miR-30c-5p PRICKLE1 0.021222006155897 0.886366656528128 0.0737328275797111 0.738753519259093 miRNATAP -0.381958630575823 2.69589979329338e-09 NA NA NA hsa-miR-30d-5p PRICKLE1 -0.38399848121878 0.000171129616944749 0.0737328275797111 0.738753519259093 miRNATAP -0.393879379857628 2.83646036120721e-05 NA NA NA hsa-miR-338-3p PRICKLE1 -0.948755228846395 8.99167125682392e-08 0.0737328275797111 0.738753519259093 miRanda -0.221000181160531 3.45790992828445e-05 NA NA NA hsa-miR-3607-3p PRICKLE1 1.01377165357363 9.13355519701165e-05 0.0737328275797111 0.738753519259093 miRNATAP -0.185574824707689 3.95267594291803e-07 NA NA NA hsa-miR-361-5p PRICKLE1 0.0803683277369505 0.314043140368058 0.0737328275797111 0.738753519259093 miRanda -0.502735982970631 3.89840393600851e-05 NA NA NA hsa-miR-532-5p PRICKLE1 -0.021857649390892 0.830992272120134 0.0737328275797111 0.738753519259093 miRNATAP -0.459835119666268 1.06053302140037e-06 NA NA NA hsa-miR-582-5p PRICKLE1 -0.0366995972742474 0.821827119138923 0.0737328275797111 0.738753519259093 miRNATAP -0.392544990715647 1.49369185689225e-11 NA NA NA hsa-miR-130b-5p PRICKLE2 1.77265255049999 1.43627774829684e-29 -0.654121176162457 3.55574969161487e-05 mirMAP -0.178433922399208 1.75843102623244e-05 NA NA NA hsa-miR-15b-3p PRICKLE2 1.05020782493504 6.38723677324836e-14 -0.654121176162457 3.55574969161487e-05 mirMAP -0.282839529104272 3.38293910482567e-09 NA NA NA hsa-miR-16-2-3p PRICKLE2 1.1567130855258 1.01867256952189e-14 -0.654121176162457 3.55574969161487e-05 mirMAP -0.346233889142856 4.38136412032952e-15 NA NA NA hsa-miR-182-5p PRICKLE2 1.15060905311096 6.25565852529946e-10 -0.654121176162457 3.55574969161487e-05 MirTarget -0.134446419027153 0.00023788826781833 NA NA NA hsa-miR-18a-5p PRICKLE2 1.65455873230328 3.76457892277775e-20 -0.654121176162457 3.55574969161487e-05 MirTarget -0.169794836444208 4.17191658752599e-06 NA NA NA hsa-miR-19a-3p PRICKLE2 1.35800152353624 2.80940447111944e-12 -0.654121176162457 3.55574969161487e-05 MirTarget;miRNATAP -0.154323907804772 8.87674876697876e-06 NA NA NA hsa-miR-19b-3p PRICKLE2 0.538732279378089 0.000622008277870679 -0.654121176162457 3.55574969161487e-05 MirTarget;miRNATAP -0.190834282299792 1.27860065410436e-05 NA NA NA hsa-miR-21-5p PRICKLE2 1.62465922021121 3.44191300985109e-58 -0.654121176162457 3.55574969161487e-05 miRNAWalker2_validate;MirTarget -0.197815129052248 0.00129342412306998 NA NA NA hsa-miR-224-3p PRICKLE2 0.502645536188015 0.0081142387260641 -0.654121176162457 3.55574969161487e-05 mirMAP -0.168400620444251 3.98379046869771e-06 NA NA NA hsa-miR-26a-2-3p PRICKLE2 -0.444498687388748 0.00325793861409413 -0.654121176162457 3.55574969161487e-05 mirMAP -0.133969923838463 0.0035432496478961 NA NA NA hsa-miR-29b-3p PRICKLE2 -0.110721443686039 0.511264554091106 -0.654121176162457 3.55574969161487e-05 MirTarget;miRNATAP -0.135212078759692 0.00103208760054343 NA NA NA hsa-miR-320a PRICKLE2 0.801356001806321 4.91397101474502e-09 -0.654121176162457 3.55574969161487e-05 mirMAP -0.197566146131534 7.49061062782031e-05 NA NA NA hsa-miR-320b PRICKLE2 1.23473838180754 3.04337566045537e-14 -0.654121176162457 3.55574969161487e-05 mirMAP -0.132051405612846 0.00150662406410612 NA NA NA hsa-miR-335-3p PRICKLE2 0.336785882180547 0.0542446207938138 -0.654121176162457 3.55574969161487e-05 mirMAP -0.117170883579583 0.00313135566753552 NA NA NA hsa-miR-33a-3p PRICKLE2 0.20371038027126 0.212335697664505 -0.654121176162457 3.55574969161487e-05 mirMAP -0.139669433128918 0.00120757877834618 NA NA NA hsa-miR-33a-5p PRICKLE2 1.12988965056352 3.35742517382153e-07 -0.654121176162457 3.55574969161487e-05 MirTarget -0.135136378975013 1.14562649150624e-05 NA NA NA hsa-miR-33b-5p PRICKLE2 0.681845193600723 0.00407790722487864 -0.654121176162457 3.55574969161487e-05 MirTarget -0.137277098403178 4.20319548742124e-06 NA NA NA hsa-miR-361-5p PRICKLE2 0.0803683277369505 0.314043140368058 -0.654121176162457 3.55574969161487e-05 MirTarget;PITA;miRanda;miRNATAP -0.243644573903098 0.0059121964629848 NA NA NA hsa-miR-362-5p PRICKLE2 0.41089772861323 0.0404254902071382 -0.654121176162457 3.55574969161487e-05 mirMAP -0.178395914165978 1.92260104676458e-07 NA NA NA hsa-miR-374a-3p PRICKLE2 -0.299190081500425 0.00682975596757891 -0.654121176162457 3.55574969161487e-05 MirTarget;miRNATAP -0.210244082096093 0.000838514362791162 NA NA NA hsa-miR-429 PRICKLE2 0.559451508722375 0.00563641638673083 -0.654121176162457 3.55574969161487e-05 miRNATAP -0.21350904995014 2.44075980337688e-10 NA NA NA hsa-miR-500a-5p PRICKLE2 0.675401699376111 8.24389004707854e-05 -0.654121176162457 3.55574969161487e-05 mirMAP -0.130597324401325 0.00115730877005655 NA NA NA hsa-miR-576-5p PRICKLE2 0.940432050128373 6.90227595663302e-12 -0.654121176162457 3.55574969161487e-05 mirMAP -0.135419770206912 0.00647872828878039 NA NA NA hsa-miR-589-3p PRICKLE2 1.59559692667315 6.2886410639161e-15 -0.654121176162457 3.55574969161487e-05 MirTarget -0.121432054176298 0.000399676705693026 NA NA NA hsa-miR-589-5p PRICKLE2 0.807877250867909 4.12262850391353e-14 -0.654121176162457 3.55574969161487e-05 MirTarget;miRNATAP -0.311691507610772 8.29484312073115e-07 NA NA NA hsa-miR-590-5p PRICKLE2 0.763025362395968 3.65305892505623e-09 -0.654121176162457 3.55574969161487e-05 MirTarget;PITA;miRanda -0.230334789919035 1.27612412584775e-05 NA NA NA hsa-miR-629-3p PRICKLE2 1.43262037314105 2.37092217984413e-19 -0.654121176162457 3.55574969161487e-05 MirTarget -0.20500259983609 9.23712598471836e-07 NA NA NA hsa-miR-7-1-3p PRICKLE2 1.13646121619622 1.49823237535933e-14 -0.654121176162457 3.55574969161487e-05 MirTarget -0.311267692364411 4.37465295788323e-12 NA NA NA hsa-miR-944 PRICKLE2 1.47323925060177 2.61626403984929e-13 -0.654121176162457 3.55574969161487e-05 PITA;miRNATAP -0.113217069754201 0.00074318008862086 NA NA NA hsa-let-7a-3p PRKACB 0.0966652362351867 0.423761916840503 -0.321098607006344 0.0228761424530327 MirTarget;mirMAP;miRNATAP -0.24351006648709 1.69808754515966e-06 NA NA NA hsa-let-7d-3p PRKACB 0.770676758773193 9.57945374997326e-13 -0.321098607006344 0.0228761424530327 MirTarget -0.261113668353957 2.78655698859518e-06 NA NA NA hsa-miR-141-3p PRKACB 0.730011517758706 0.000120338355004032 -0.321098607006344 0.0228761424530327 MirTarget;TargetScan;miRNATAP -0.267679710851304 1.06126331262823e-17 NA NA NA hsa-miR-16-2-3p PRKACB 1.1567130855258 1.01867256952189e-14 -0.321098607006344 0.0228761424530327 mirMAP -0.25465198696094 1.15210482297961e-10 NA NA NA hsa-miR-17-5p PRKACB 1.41924888736771 2.75805544953758e-18 -0.321098607006344 0.0228761424530327 TargetScan -0.320719783263986 1.04231465157064e-19 NA NA NA hsa-miR-182-5p PRKACB 1.15060905311096 6.25565852529946e-10 -0.321098607006344 0.0228761424530327 MirTarget;miRNATAP -0.192126378855167 2.14564015173888e-09 NA NA NA hsa-miR-183-5p PRKACB 1.4313129319945 6.25230916431996e-14 -0.321098607006344 0.0228761424530327 MirTarget -0.193043292756991 4.67956422537156e-10 NA NA NA hsa-miR-18a-5p PRKACB 1.65455873230328 3.76457892277775e-20 -0.321098607006344 0.0228761424530327 miRNATAP -0.281434127350525 9.68681768909003e-19 NA NA NA hsa-miR-193a-3p PRKACB 0.22120710726779 0.111827069464729 -0.321098607006344 0.0228761424530327 miRanda -0.120890648652317 0.00645270297281106 NA NA NA hsa-miR-19a-3p PRKACB 1.35800152353624 2.80940447111944e-12 -0.321098607006344 0.0228761424530327 MirTarget;miRNATAP -0.258968002486092 6.18986461469059e-18 NA NA NA hsa-miR-19b-3p PRKACB 0.538732279378089 0.000622008277870679 -0.321098607006344 0.0228761424530327 miRNAWalker2_validate;MirTarget;miRNATAP -0.335571469796732 5.37740203716601e-19 NA NA NA hsa-miR-200a-3p PRKACB 0.607140814457753 0.00289840524858752 -0.321098607006344 0.0228761424530327 MirTarget;miRNATAP -0.241062026533704 1.65937825863575e-16 NA NA NA hsa-miR-200b-3p PRKACB 0.0717138787925347 0.682858087587209 -0.321098607006344 0.0228761424530327 MirTarget;TargetScan -0.231640096513903 1.90730092010153e-11 NA NA NA hsa-miR-200c-3p PRKACB 0.630251054099546 0.000131975031451555 -0.321098607006344 0.0228761424530327 MirTarget;miRNATAP -0.209750443181332 1.11607954800956e-08 NA NA NA hsa-miR-30d-3p PRKACB -0.577371911152798 2.02950840095287e-06 -0.321098607006344 0.0228761424530327 mirMAP -0.229710131067783 4.74198208250703e-06 NA NA NA hsa-miR-339-5p PRKACB 1.07771430326938 2.45772601859307e-09 -0.321098607006344 0.0228761424530327 miRanda -0.226395664639244 6.08522673686748e-12 NA NA NA hsa-miR-34a-5p PRKACB -0.117372471043915 0.364001947180738 -0.321098607006344 0.0228761424530327 miRNATAP -0.188258649958631 7.8062126512609e-05 NA NA NA hsa-miR-362-5p PRKACB 0.41089772861323 0.0404254902071382 -0.321098607006344 0.0228761424530327 PITA -0.231677226283398 9.49014505345782e-15 NA NA NA hsa-miR-429 PRKACB 0.559451508722375 0.00563641638673083 -0.321098607006344 0.0228761424530327 MirTarget;PITA;miRanda;miRNATAP -0.24828232747711 3.61288238132463e-17 NA NA NA hsa-miR-532-5p PRKACB -0.021857649390892 0.830992272120134 -0.321098607006344 0.0228761424530327 PITA -0.227164270683247 0.000174154322184187 NA NA NA hsa-miR-590-5p PRKACB 0.763025362395968 3.65305892505623e-09 -0.321098607006344 0.0228761424530327 miRanda -0.305639629088135 3.88857071786905e-11 NA NA NA hsa-miR-7-1-3p PRKACB 1.13646121619622 1.49823237535933e-14 -0.321098607006344 0.0228761424530327 mirMAP -0.163214783006832 5.48095567644113e-05 NA NA NA hsa-miR-708-3p PRKACB 1.32647174389322 4.87465491977979e-16 -0.321098607006344 0.0228761424530327 mirMAP -0.239908721941593 2.49822385276827e-11 NA NA NA hsa-miR-93-5p PRKACB 1.61042951896619 5.1280369606967e-24 -0.321098607006344 0.0228761424530327 miRNAWalker2_validate -0.265261521642743 2.04882387197337e-13 NA NA NA hsa-miR-944 PRKACB 1.47323925060177 2.61626403984929e-13 -0.321098607006344 0.0228761424530327 MirTarget;mirMAP -0.138499316290303 2.90532544481091e-06 NA NA NA hsa-miR-96-5p PRKACB 1.42326703011157 4.39736150032373e-14 -0.321098607006344 0.0228761424530327 miRNATAP -0.258796730941182 5.34409541983872e-17 NA NA NA hsa-miR-103a-2-5p PRKCA 1.37988337975616 6.74852943995612e-08 0.3178322857115 0.0462170958036427 mirMAP -0.117780407567177 5.24493745308123e-05 NA NA NA hsa-miR-150-5p PRKCA -0.243749814009231 0.331546276920338 0.3178322857115 0.0462170958036427 mirMAP -0.104022182991935 0.000162874861270433 NA NA NA hsa-miR-17-3p PRKCA -0.0127974722290336 0.909559935689875 0.3178322857115 0.0462170958036427 miRNAWalker2_validate -0.214761659225552 0.000540115676811066 NA NA NA hsa-miR-181c-5p PRKCA -0.168991199007857 0.196949106150297 0.3178322857115 0.0462170958036427 mirMAP -0.230481828890932 1.38543638100701e-05 NA NA NA hsa-miR-183-5p PRKCA 1.4313129319945 6.25230916431996e-14 0.3178322857115 0.0462170958036427 miRNATAP -0.123604672252822 0.000489233186271866 NA NA NA hsa-miR-186-5p PRKCA 0.353452958261612 0.000145058448579496 0.3178322857115 0.0462170958036427 miRNATAP -0.197395594611936 0.008653002308399 NA NA NA hsa-miR-1976 PRKCA 0.638808083289405 2.94840228896364e-07 0.3178322857115 0.0462170958036427 miRNATAP -0.216146135639291 9.07994360436659e-05 NA NA NA hsa-miR-19b-1-5p PRKCA 0.757034032029085 2.99828133413343e-07 0.3178322857115 0.0462170958036427 mirMAP -0.214408086876696 3.69042545103291e-06 NA NA NA hsa-miR-200b-3p PRKCA 0.0717138787925347 0.682858087587209 0.3178322857115 0.0462170958036427 TargetScan -0.341691724440131 5.17210999735547e-19 NA NA NA hsa-miR-200c-3p PRKCA 0.630251054099546 0.000131975031451555 0.3178322857115 0.0462170958036427 miRNATAP -0.258050454876613 4.38353493232271e-10 NA NA NA hsa-miR-24-2-5p PRKCA 1.27293931700635 4.48240091510596e-15 0.3178322857115 0.0462170958036427 miRNAWalker2_validate -0.121435567912037 0.00357611288622236 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-27b-5p PRKCA 0.580870079022649 0.000181529223377382 0.3178322857115 0.0462170958036427 mirMAP -0.227514723686497 2.70991772299128e-07 NA NA NA hsa-miR-29b-2-5p PRKCA -0.502720326849742 0.000730448246894952 0.3178322857115 0.0462170958036427 mirMAP -0.296683337612196 9.93635847649949e-11 NA NA NA hsa-miR-30d-3p PRKCA -0.577371911152798 2.02950840095287e-06 0.3178322857115 0.0462170958036427 mirMAP -0.332961077885486 3.40360771990262e-09 NA NA NA hsa-miR-30e-3p PRKCA -0.890635378639789 1.65740480611339e-16 0.3178322857115 0.0462170958036427 mirMAP -0.199675307499267 0.00146746163627339 NA NA NA hsa-miR-339-5p PRKCA 1.07771430326938 2.45772601859307e-09 0.3178322857115 0.0462170958036427 mirMAP -0.148559462896231 8.30706937469769e-05 NA NA NA hsa-miR-3607-3p PRKCA 1.01377165357363 9.13355519701165e-05 0.3178322857115 0.0462170958036427 mirMAP -0.133480273866349 4.39877789751401e-07 NA NA NA hsa-miR-362-5p PRKCA 0.41089772861323 0.0404254902071382 0.3178322857115 0.0462170958036427 TargetScan;miRNATAP -0.223333590994173 5.47462768229892e-11 NA NA NA hsa-miR-374a-5p PRKCA -0.621903385111545 6.61791773205282e-12 0.3178322857115 0.0462170958036427 mirMAP -0.205530215602705 0.00688190144820459 NA NA NA hsa-miR-429 PRKCA 0.559451508722375 0.00563641638673083 0.3178322857115 0.0462170958036427 miRanda;miRNATAP -0.266671632635371 1.42360916592268e-15 NA NA NA hsa-miR-500a-5p PRKCA 0.675401699376111 8.24389004707854e-05 0.3178322857115 0.0462170958036427 miRNATAP -0.174713694092824 1.31490069031191e-05 NA NA NA hsa-miR-501-5p PRKCA 1.02806906860218 1.63456814370548e-09 0.3178322857115 0.0462170958036427 miRNATAP -0.164099616970046 5.18294254195767e-05 NA NA NA hsa-miR-505-5p PRKCA 1.25888458076414 7.80089782306577e-13 0.3178322857115 0.0462170958036427 mirMAP -0.108990500629565 0.00483820175668253 NA NA NA hsa-miR-532-3p PRKCA 0.80240056676907 1.08989551712617e-09 0.3178322857115 0.0462170958036427 mirMAP;miRNATAP -0.201724862387695 0.000103690896052721 NA NA NA hsa-miR-590-3p PRKCA 0.221436901462551 0.0965904764063157 0.3178322857115 0.0462170958036427 PITA;miRanda;mirMAP;miRNATAP -0.159630241178647 0.00227859309388304 NA NA NA hsa-miR-92a-3p PRKCA 0.994679542307232 1.32587679156217e-16 0.3178322857115 0.0462170958036427 miRNAWalker2_validate -0.239077901540622 1.99085302915519e-05 NA NA NA hsa-miR-93-3p PRKCA 1.69225547123293 1.50964095575087e-25 0.3178322857115 0.0462170958036427 mirMAP -0.142996896050503 0.000455152507074917 NA NA NA hsa-miR-200b-3p PRKCB 0.0717138787925347 0.682858087587209 -0.00995382054367333 0.966062170170983 MirTarget -0.25314056822959 1.19976246306159e-05 NA NA NA hsa-miR-200c-3p PRKCB 0.630251054099546 0.000131975031451555 -0.00995382054367333 0.966062170170983 MirTarget;miRNATAP -0.247883706249509 5.19535947946646e-05 NA NA NA hsa-miR-205-3p PRKCB 1.2960640797621 5.80786479909147e-11 -0.00995382054367333 0.966062170170983 mirMAP -0.139761356797048 0.00563704149985681 NA NA NA hsa-miR-23a-3p PRKCB 0.348231698801568 6.4911858506572e-05 -0.00995382054367333 0.966062170170983 mirMAP -0.585222638829513 5.31039580277569e-07 NA NA NA hsa-miR-24-3p PRKCB 0.13115428390042 0.203891651275156 -0.00995382054367333 0.966062170170983 miRNATAP -0.412248047896016 3.20409690969774e-05 NA NA NA hsa-miR-27a-3p PRKCB 0.348456440505425 0.00126682892514312 -0.00995382054367333 0.966062170170983 MirTarget;miRNATAP -0.586533342240413 3.06369418405208e-10 NA NA NA hsa-miR-335-3p PRKCB 0.336785882180547 0.0542446207938138 -0.00995382054367333 0.966062170170983 mirMAP -0.150801933292581 0.00964223317290781 NA NA NA hsa-miR-338-3p PRKCB -0.948755228846395 8.99167125682392e-08 -0.00995382054367333 0.966062170170983 miRanda -0.189063660103368 0.000843153123017634 NA NA NA hsa-miR-361-5p PRKCB 0.0803683277369505 0.314043140368058 -0.00995382054367333 0.966062170170983 MirTarget;miRanda;miRNATAP -0.375874177784515 0.00379764519521529 NA NA NA hsa-miR-429 PRKCB 0.559451508722375 0.00563641638673083 -0.00995382054367333 0.966062170170983 MirTarget;miRanda;miRNATAP -0.30122694602295 1.22808222979422e-09 NA NA NA hsa-miR-450b-5p PRKCB 1.25529820885833 1.18847120528666e-15 -0.00995382054367333 0.966062170170983 miRNATAP -0.164181125995606 0.00942767159258168 NA NA NA hsa-miR-452-3p PRKCB 1.09618110917892 2.21867884261816e-07 -0.00995382054367333 0.966062170170983 mirMAP -0.288633705564416 7.41556259016727e-10 NA NA NA hsa-miR-589-3p PRKCB 1.59559692667315 6.2886410639161e-15 -0.00995382054367333 0.966062170170983 mirMAP -0.224077186704912 7.93186780188175e-06 NA NA NA hsa-miR-590-5p PRKCB 0.763025362395968 3.65305892505623e-09 -0.00995382054367333 0.966062170170983 miRanda -0.36636674657937 2.16525521339557e-06 NA NA NA hsa-miR-944 PRKCB 1.47323925060177 2.61626403984929e-13 -0.00995382054367333 0.966062170170983 mirMAP -0.228083074030307 3.27391957426865e-06 NA NA NA hsa-miR-181a-5p PRKX 0.819060835827404 1.38616688310277e-13 -0.151603564440898 0.3779654538133 mirMAP -0.207430719919465 0.00177099251431452 NA NA NA hsa-miR-181b-5p PRKX 0.974255518824355 2.64876280203475e-16 -0.151603564440898 0.3779654538133 mirMAP -0.395265525562346 5.7519252637977e-11 NA NA NA hsa-miR-450b-5p PRKX 1.25529820885833 1.18847120528666e-15 -0.151603564440898 0.3779654538133 mirMAP -0.192275284682013 3.2143180494236e-05 NA NA NA hsa-miR-539-5p PRKX -0.15206998860136 0.492550733728996 -0.151603564440898 0.3779654538133 mirMAP -0.105402290296118 0.00200608976227561 NA NA NA hsa-miR-542-3p PRKX 0.643308814904977 8.81635403230104e-07 -0.151603564440898 0.3779654538133 mirMAP -0.325292565431366 6.95556775285496e-09 NA NA NA hsa-miR-140-5p PSEN1 -0.412389003031485 0.000136051708543369 0.139262734198686 0.0256817912349285 MirTarget;miRanda -0.161659260570196 5.52777646172835e-11 NA NA NA hsa-miR-186-5p PSEN1 0.353452958261612 0.000145058448579496 0.139262734198686 0.0256817912349285 mirMAP -0.118584367969577 4.67423193381232e-05 NA NA NA hsa-miR-628-5p PSEN1 -0.554239048796013 4.92386883216087e-05 0.139262734198686 0.0256817912349285 mirMAP -0.105021691243069 7.82614832852197e-08 NA NA NA hsa-miR-382-5p RAC1 -0.512675955239656 0.00311534081639733 0.060247613846359 0.436073210860324 MirTarget -0.110732405915093 6.53593148835981e-09 NA NA NA hsa-miR-375 RAC2 -4.24070205340868 7.48368361454041e-28 1.54722243723033 1.85515860629167e-17 miRanda -0.164694891845942 1.8370066353598e-17 NA NA NA hsa-miR-130b-5p RHOA 1.77265255049999 1.43627774829684e-29 -0.388216260165068 4.48279253908352e-10 MirTarget;miRNATAP -0.107033559733647 4.21158617305132e-11 NA NA NA hsa-miR-200b-3p RHOA 0.0717138787925347 0.682858087587209 -0.388216260165068 4.48279253908352e-10 MirTarget;TargetScan -0.104184324891353 1.21846120758679e-11 NA NA NA hsa-miR-200c-3p RHOA 0.630251054099546 0.000131975031451555 -0.388216260165068 4.48279253908352e-10 miRNAWalker2_validate;MirTarget;miRNATAP -0.100826191340189 6.50602293179483e-10 NA NA NA hsa-miR-361-5p RHOA 0.0803683277369505 0.314043140368058 -0.388216260165068 4.48279253908352e-10 MirTarget;PITA;miRanda -0.150868348890832 1.4439671126465e-05 NA NA NA hsa-miR-429 RHOA 0.559451508722375 0.00563641638673083 -0.388216260165068 4.48279253908352e-10 MirTarget;PITA;miRanda;miRNATAP -0.100812132665556 2.34045632505225e-14 NA NA NA hsa-let-7a-3p ROCK1 0.0966652362351867 0.423761916840503 0.172036465483973 0.137257282365385 MirTarget -0.180879475579613 1.46084214407693e-05 NA NA NA hsa-miR-16-1-3p ROCK1 0.955017760172879 5.95379292601146e-11 0.172036465483973 0.137257282365385 MirTarget -0.137151267227965 5.17436037933244e-05 NA NA NA hsa-miR-199b-5p ROCK1 -1.08432682485992 7.68241801134089e-10 0.172036465483973 0.137257282365385 miRanda -0.104406273592545 0.000196575786894117 NA NA NA hsa-miR-320a ROCK1 0.801356001806321 4.91397101474502e-09 0.172036465483973 0.137257282365385 miRanda -0.153206287171185 2.27941054528062e-05 NA NA NA hsa-miR-324-5p ROCK1 1.66709479707179 1.45961450445769e-23 0.172036465483973 0.137257282365385 MirTarget;PITA;miRanda -0.113762647703089 7.81731388577114e-05 NA NA NA hsa-miR-582-5p ROCK1 -0.0366995972742474 0.821827119138923 0.172036465483973 0.137257282365385 PITA -0.11942939369136 0.000110248240380452 NA NA NA hsa-miR-664a-3p ROCK1 -0.256108763664991 0.0513188660751664 0.172036465483973 0.137257282365385 mirMAP -0.241983940086317 1.64749074912771e-10 NA NA NA hsa-let-7a-3p ROCK2 0.0966652362351867 0.423761916840503 -0.314778959737315 0.0707629583479502 mirMAP -0.29587653185868 2.4607937751627e-06 NA NA NA hsa-miR-142-3p ROCK2 1.12754191614028 1.68798138028946e-08 -0.314778959737315 0.0707629583479502 PITA;miRanda;miRNATAP -0.10895045820344 0.00361998443461654 NA NA NA hsa-miR-17-5p ROCK2 1.41924888736771 2.75805544953758e-18 -0.314778959737315 0.0707629583479502 TargetScan -0.296121836340494 2.43556558880277e-11 NA NA NA hsa-miR-200b-3p ROCK2 0.0717138787925347 0.682858087587209 -0.314778959737315 0.0707629583479502 TargetScan -0.144914038275119 0.000811003667588 NA NA NA hsa-miR-3607-3p ROCK2 1.01377165357363 9.13355519701165e-05 -0.314778959737315 0.0707629583479502 mirMAP -0.178170758242282 5.29793660164636e-10 NA NA NA hsa-miR-429 ROCK2 0.559451508722375 0.00563641638673083 -0.314778959737315 0.0707629583479502 PITA;miRanda;miRNATAP -0.210236542297368 1.37509024229653e-08 NA NA NA hsa-miR-500a-5p ROCK2 0.675401699376111 8.24389004707854e-05 -0.314778959737315 0.0707629583479502 mirMAP -0.356235994965815 8.11168219955949e-17 NA NA NA hsa-miR-582-5p ROCK2 -0.0366995972742474 0.821827119138923 -0.314778959737315 0.0707629583479502 mirMAP -0.167757713604258 0.000318294341731786 NA NA NA hsa-miR-589-3p ROCK2 1.59559692667315 6.2886410639161e-15 -0.314778959737315 0.0707629583479502 mirMAP -0.19403465901479 1.92343537691216e-07 NA NA NA hsa-miR-590-3p ROCK2 0.221436901462551 0.0965904764063157 -0.314778959737315 0.0707629583479502 miRanda;mirMAP -0.158177217569221 0.00568207148649583 NA NA NA hsa-miR-140-5p RUVBL1 -0.412389003031485 0.000136051708543369 0.887346667534344 7.57424322413335e-21 miRanda -0.120068364660592 0.00250601939240572 NA NA NA hsa-miR-140-3p SENP2 -0.967453553824782 7.6999446305445e-23 0.478313942818511 5.08188938306924e-07 mirMAP -0.180875651354018 9.55940916178717e-06 NA NA NA hsa-miR-338-3p SENP2 -0.948755228846395 8.99167125682392e-08 0.478313942818511 5.08188938306924e-07 miRanda -0.115795074362226 5.45551014233136e-07 NA NA NA hsa-miR-365a-3p SENP2 0.446833934952926 0.00233857759218299 0.478313942818511 5.08188938306924e-07 mirMAP -0.134281445634329 2.06146808081965e-06 NA NA NA hsa-miR-1301-3p SFRP1 2.13677668481885 6.11093268540831e-44 -2.95958078384978 4.75499210511498e-13 MirTarget -0.729813905963799 9.24664179237345e-12 NA NA NA hsa-miR-16-1-3p SFRP1 0.955017760172879 5.95379292601146e-11 -2.95958078384978 4.75499210511498e-13 MirTarget -0.500471005544228 4.65146708832975e-05 NA NA NA hsa-miR-182-5p SFRP1 1.15060905311096 6.25565852529946e-10 -2.95958078384978 4.75499210511498e-13 mirMAP -0.626181033583446 4.25771390874997e-11 NA NA NA hsa-miR-19b-1-5p SFRP1 0.757034032029085 2.99828133413343e-07 -2.95958078384978 4.75499210511498e-13 MirTarget -0.580873099961256 1.81367093476391e-06 NA NA NA hsa-miR-205-3p SFRP1 1.2960640797621 5.80786479909147e-11 -2.95958078384978 4.75499210511498e-13 MirTarget -0.35222789578559 9.48662601459576e-05 NA NA NA hsa-miR-34b-3p SFRP1 1.05595687443274 4.36830248743191e-05 -2.95958078384978 4.75499210511498e-13 MirTarget -0.222265866926499 0.0019151659754814 NA NA NA hsa-miR-429 SFRP1 0.559451508722375 0.00563641638673083 -2.95958078384978 4.75499210511498e-13 miRNATAP -0.627384286528489 1.24094859245384e-12 NA NA NA hsa-miR-501-5p SFRP1 1.02806906860218 1.63456814370548e-09 -2.95958078384978 4.75499210511498e-13 mirMAP -0.29651175541051 0.00559613064254346 NA NA NA hsa-miR-576-5p SFRP1 0.940432050128373 6.90227595663302e-12 -2.95958078384978 4.75499210511498e-13 MirTarget;PITA -0.580201757626416 8.30377833191631e-06 NA NA NA hsa-miR-7-1-3p SFRP1 1.13646121619622 1.49823237535933e-14 -2.95958078384978 4.75499210511498e-13 MirTarget;mirMAP -0.541291274877068 6.34287106544378e-06 NA NA NA hsa-miR-940 SFRP1 1.25303020594374 1.3005368359451e-10 -2.95958078384978 4.75499210511498e-13 MirTarget -0.376729213752198 4.89984969206311e-05 NA NA NA hsa-miR-96-5p SFRP1 1.42326703011157 4.39736150032373e-14 -2.95958078384978 4.75499210511498e-13 mirMAP -0.744633004325632 5.40718682100252e-16 NA NA NA hsa-let-7a-3p SFRP2 0.0966652362351867 0.423761916840503 0.108735635259989 0.728487132305578 miRNATAP -0.345213855574903 0.00235978423629034 NA NA NA hsa-miR-33a-3p SFRP2 0.20371038027126 0.212335697664505 0.108735635259989 0.728487132305578 miRNATAP -0.642158038738297 9.05915279900461e-15 NA NA NA hsa-miR-582-5p SFRP2 -0.0366995972742474 0.821827119138923 0.108735635259989 0.728487132305578 miRNATAP -0.658417002748078 7.61115006051773e-16 NA NA NA hsa-miR-590-3p SFRP2 0.221436901462551 0.0965904764063157 0.108735635259989 0.728487132305578 miRanda -0.575547884401482 1.45590253171853e-08 NA NA NA hsa-miR-135b-5p SFRP4 1.5570143078477 4.60753610971455e-13 0.787276662506151 0.104664692494185 MirTarget -0.808657146273094 3.34911831846647e-18 NA NA NA hsa-miR-144-5p SFRP4 -1.00191595665045 9.05682140522593e-05 0.787276662506151 0.104664692494185 MirTarget -0.524055767236125 8.47283924136114e-11 NA NA NA hsa-miR-26b-5p SFRP4 -0.254478038884324 0.0285227763044636 0.787276662506151 0.104664692494185 miRNAWalker2_validate -0.842276183200146 3.61994203688476e-06 NA NA NA hsa-miR-3607-3p SFRP4 1.01377165357363 9.13355519701165e-05 0.787276662506151 0.104664692494185 MirTarget -0.401474762653473 6.07127804333035e-07 NA NA NA hsa-miR-375 SFRP4 -4.24070205340868 7.48368361454041e-28 0.787276662506151 0.104664692494185 miRanda -0.211604216073612 3.74742151703862e-05 NA NA NA hsa-miR-429 SFRP4 0.559451508722375 0.00563641638673083 0.787276662506151 0.104664692494185 miRanda -0.745325666864608 3.02039176651739e-13 NA NA NA hsa-miR-944 SFRP4 1.47323925060177 2.61626403984929e-13 0.787276662506151 0.104664692494185 mirMAP -0.398427878373845 9.59570170775211e-05 NA NA NA hsa-miR-140-5p SIAH1 -0.412389003031485 0.000136051708543369 0.695028461694744 1.42160034478959e-12 PITA;miRanda;miRNATAP -0.207774194261363 2.19499291468573e-07 NA NA NA hsa-miR-15b-5p SIAH1 0.85315666454713 3.79816274836297e-12 0.695028461694744 1.42160034478959e-12 miRNATAP -0.181053319601286 1.69772082360023e-07 NA NA NA hsa-miR-16-5p SIAH1 0.521122945828175 1.40561786410572e-06 0.695028461694744 1.42160034478959e-12 miRNATAP -0.194739668892016 1.13357316469618e-06 NA NA NA hsa-miR-195-5p SIAH1 -1.8367376818177 6.9944883988895e-31 0.695028461694744 1.42160034478959e-12 miRNATAP -0.133263109982517 2.01074749815401e-07 NA NA NA hsa-miR-200b-3p SIAH1 0.0717138787925347 0.682858087587209 0.695028461694744 1.42160034478959e-12 TargetScan -0.106298159106421 1.80557172080532e-05 NA NA NA hsa-miR-30a-3p SIAH1 -2.26144364746452 8.12421214153823e-31 0.695028461694744 1.42160034478959e-12 miRNATAP -0.174890148532465 7.30317535906173e-18 NA NA NA hsa-miR-30d-3p SIAH1 -0.577371911152798 2.02950840095287e-06 0.695028461694744 1.42160034478959e-12 miRNATAP -0.255415921773443 3.29312061122369e-13 NA NA NA hsa-miR-362-3p SIAH1 -0.697212068252854 2.61718493418184e-06 0.695028461694744 1.42160034478959e-12 miRanda -0.101004263498116 0.000561631453408437 NA NA NA hsa-miR-497-5p SIAH1 -0.966244470847844 5.26505649147857e-12 0.695028461694744 1.42160034478959e-12 miRNATAP -0.134167830537808 1.03851368746302e-05 NA NA NA hsa-miR-532-5p SIAH1 -0.021857649390892 0.830992272120134 0.695028461694744 1.42160034478959e-12 PITA;miRNATAP -0.19848824207632 3.48661485054702e-06 NA NA NA hsa-miR-590-3p SIAH1 0.221436901462551 0.0965904764063157 0.695028461694744 1.42160034478959e-12 PITA;miRanda;mirMAP -0.107278932511189 0.00108576154877503 NA NA NA hsa-miR-130b-3p SKP1 1.44628430084411 9.13980959861273e-24 -0.426414078743471 1.8274515909563e-09 MirTarget -0.111425580134606 6.14058372927867e-08 NA NA NA hsa-miR-148b-3p SKP1 0.386859166050437 4.6728211830726e-06 -0.426414078743471 1.8274515909563e-09 MirTarget -0.113875723617554 0.00219226586497516 NA NA NA hsa-miR-152-3p SKP1 -0.382486223604156 0.00710736505198702 -0.426414078743471 1.8274515909563e-09 MirTarget -0.114177290928382 1.6385750636398e-07 NA NA NA hsa-let-7a-3p SMAD2 0.0966652362351867 0.423761916840503 0.0243635060778491 0.76464000338556 mirMAP -0.120201003720566 4.00233873380995e-05 NA NA NA hsa-miR-181a-5p SMAD2 0.819060835827404 1.38616688310277e-13 0.0243635060778491 0.76464000338556 mirMAP -0.123663686344939 7.35992784180675e-05 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 0.974255518824355 2.64876280203475e-16 0.0243635060778491 0.76464000338556 mirMAP -0.187179272190298 4.69209630284474e-11 NA NA NA hsa-miR-455-5p SMAD2 1.408595672323 5.52039116456697e-22 0.0243635060778491 0.76464000338556 miRanda -0.146407779382659 1.44497506412449e-10 NA NA NA hsa-miR-145-5p SMAD3 -0.46917511594055 0.000685297625493134 -0.143490080047147 0.241618109620266 MirTarget;miRNATAP -0.115484614688291 0.00271929213208624 27237033 MiR 145 and miR 203 represses TGF β induced epithelial mesenchymal transition and invasion by inhibiting SMAD3 in non small cell lung cancer cells; siRNA-mediated knockdown of SMAD3 copied the phenotype of miR-145 and miR-203 overexpression in A549 and 95C cells; MiR-145 and miR-203 inhibited TGF-β-induced EMT and invasion through repression of SMAD3 in NSCLC cells lung squamous cell cancer hsa-miR-155-5p SMAD3 0.533437622040649 0.00248671179205372 -0.143490080047147 0.241618109620266 miRNAWalker2_validate -0.125492484204873 2.91075561128582e-05 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-186-5p SMAD3 0.353452958261612 0.000145058448579496 -0.143490080047147 0.241618109620266 mirMAP -0.183402338959526 0.00144579229064042 NA NA NA hsa-miR-424-5p SMAD3 1.48125289532143 9.10372985713165e-19 -0.143490080047147 0.241618109620266 MirTarget -0.158147445199969 2.11197443864582e-07 27655675 miR 424 5p promotes proliferation of gastric cancer by targeting Smad3 through TGF β signaling pathway; QRT-PCR was used to determine the expression levels of miR-424-5p and Smad3; Luciferase reporter assay and western blotting were used to prove that Smad3 was one of the direct targets of miR-424-5p; In addition luciferase reporter assay and western blotting assay revealed that Smad3 was a direct target of miR-424-5p; Over-expression of Smad3 could partially reverse the effects of miR-424-5p on GC cell proliferation; Our study further revealed that miR-424-5p could inhibit TGF-β signaling pathway by Smad3 gastric cancer hsa-let-7a-3p SMAD4 0.0966652362351867 0.423761916840503 -0.429721565372713 9.05223747485839e-07 mirMAP -0.127673799060679 6.14893432718486e-05 NA NA NA hsa-miR-130a-3p SMAD4 0.67051191119964 4.89747518735144e-06 -0.429721565372713 9.05223747485839e-07 miRNAWalker2_validate;miRNATAP -0.144664759620316 1.85930895184609e-08 NA NA NA hsa-miR-18a-5p SMAD4 1.65455873230328 3.76457892277775e-20 -0.429721565372713 9.05223747485839e-07 miRNAWalker2_validate -0.132804055287407 4.94433335605224e-11 NA NA NA hsa-miR-19a-3p SMAD4 1.35800152353624 2.80940447111944e-12 -0.429721565372713 9.05223747485839e-07 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.111631809114141 5.01550217662971e-09 NA NA NA hsa-miR-21-3p SMAD4 1.25126438776674 2.4124216716282e-17 -0.429721565372713 9.05223747485839e-07 mirMAP -0.132998757674157 1.0204793984454e-07 NA NA NA hsa-miR-224-5p SMAD4 1.94534596857416 1.88348779207332e-19 -0.429721565372713 9.05223747485839e-07 miRNAWalker2_validate;miRTarBase;MirTarget -0.104382574165612 6.63646727576293e-10 24817781;24152489;26187928;23913306;25804630;26307684 Increased miR-224 diminished Cdc42 and SMAD4 expressions at both the protein and mRNA levels and inhibited the formation of actin filaments;In addition the regulation of SMAD4 by miR-224 was evaluated by qRT-PCR Western blotting and luciferase reporter assays; Furthermore the over-expression of miR-224 in CRC cell lines decreased SMAD4 expression at the translational level and decreased SMAD4-driven luciferase-reporter activity;Increased miR-224 expression promotes cell migration invasion and proliferation by directly targeting the tumor suppressors TNFα-induced protein 1 TNFAIP1 and SMAD4; Up-regulated miR-224 thus facilitates tumor progression by shifting the equilibrium of the partially antagonist functions of SMAD4 and TNFAIP1 toward enhanced invasion and growth in NSCLC;Our in vitro study demonstrated that miR-224 played an oncogenic role in hepatoma cell migration and tumor formation through silencing its target gene Smad4; A noncanonical pathway links autophagy miR-224 Smad4 and HBV-associated HCC;We identified SMAD4 as a miR-224 target and observed negative correlation Spearman Rs=-0.44 p<0.0001 between SMAD4 and miR-224 expression in clinical samples; In the TCGA set combined analysis of miR-224 with SMAD4 expression enhanced correlation with survival HR 4.12 95% CI 1.1 to 15.41 p=0.0175; MiR-224 promotes CRC metastasis at least in part through the regulation of SMAD4;We further demonstrated that miR-224 functions as an oncogene in NSCLC by directly targeting TNFAIP1 and SMAD4 ;;cell migration;progression;cell migration;poor survival;metastasis; colorectal cancer;colorectal cancer;lung squamous cell cancer;liver cancer;colorectal cancer;lung cancer hsa-miR-2355-5p SMAD4 1.47205546931107 8.65192179636668e-19 -0.429721565372713 9.05223747485839e-07 MirTarget -0.198974232428425 2.21498106355127e-20 NA NA NA hsa-miR-27a-3p SMAD4 0.348456440505425 0.00126682892514312 -0.429721565372713 9.05223747485839e-07 MirTarget -0.157382002902766 9.11244451316926e-06 NA NA NA hsa-miR-450b-5p SMAD4 1.25529820885833 1.18847120528666e-15 -0.429721565372713 9.05223747485839e-07 mirMAP -0.113363230314613 1.66484502341078e-06 NA NA NA hsa-miR-454-3p SMAD4 1.54137391927201 4.15861570449376e-20 -0.429721565372713 9.05223747485839e-07 miRNAWalker2_validate;miRNATAP -0.107809125022266 8.27427228720796e-07 NA NA NA hsa-miR-576-5p SMAD4 0.940432050128373 6.90227595663302e-12 -0.429721565372713 9.05223747485839e-07 mirMAP -0.137995054888109 4.27825973334458e-07 NA NA NA hsa-miR-590-5p SMAD4 0.763025362395968 3.65305892505623e-09 -0.429721565372713 9.05223747485839e-07 miRanda -0.107285938961663 0.000249372347039553 NA NA NA hsa-miR-141-3p SOX17 0.730011517758706 0.000120338355004032 -0.94050965477685 5.85483993492757e-07 TargetScan -0.382628059373194 6.85627462038684e-20 22921431 Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer; MicroRNA 141 was also found to down-regulate SOX17 expression and activate the WNT signal pathway esophageal cancer hsa-miR-590-3p SOX17 0.221436901462551 0.0965904764063157 -0.94050965477685 5.85483993492757e-07 miRanda;miRNATAP -0.180637351967383 0.00381501615463461 NA NA NA hsa-miR-590-5p SOX17 0.763025362395968 3.65305892505623e-09 -0.94050965477685 5.85483993492757e-07 miRanda -0.306017561543504 1.15320583561035e-06 NA NA NA hsa-miR-127-5p TBL1X -0.605739525751187 0.000636065602565634 -0.197631988748507 0.233122599072657 miRNATAP -0.110002308440903 0.00668562569498482 NA NA NA hsa-miR-135b-5p TBL1X 1.5570143078477 4.60753610971455e-13 -0.197631988748507 0.233122599072657 mirMAP -0.10520414169006 0.0012960229949763 NA NA NA hsa-miR-139-5p TBL1X -1.46099200329485 7.85040381494472e-22 -0.197631988748507 0.233122599072657 miRanda -0.124513177809123 0.00629547269064192 NA NA NA hsa-miR-142-3p TBL1X 1.12754191614028 1.68798138028946e-08 -0.197631988748507 0.233122599072657 MirTarget;PITA;miRanda;miRNATAP -0.121031620740603 0.000660784508045087 NA NA NA hsa-miR-181a-5p TBL1X 0.819060835827404 1.38616688310277e-13 -0.197631988748507 0.233122599072657 MirTarget;miRNATAP -0.426567838092845 1.1713025434408e-11 NA NA NA hsa-miR-181b-5p TBL1X 0.974255518824355 2.64876280203475e-16 -0.197631988748507 0.233122599072657 MirTarget;miRNATAP -0.493372268925582 7.62835873191357e-18 NA NA NA hsa-miR-22-5p TBL1X 0.706731861922839 3.44318705980007e-07 -0.197631988748507 0.233122599072657 mirMAP -0.408084171184476 4.58531422234794e-16 NA NA NA hsa-miR-29b-1-5p TBL1X 1.39669186711325 4.36960953138935e-11 -0.197631988748507 0.233122599072657 mirMAP -0.240088722738601 2.22289794731703e-13 NA NA NA hsa-miR-3614-5p TBL1X 0.955957969488529 2.95347675446694e-05 -0.197631988748507 0.233122599072657 miRNATAP -0.157256893034691 4.0976108004914e-07 NA NA NA hsa-miR-450b-5p TBL1X 1.25529820885833 1.18847120528666e-15 -0.197631988748507 0.233122599072657 mirMAP -0.172738211945046 0.000108872446301373 NA NA NA hsa-miR-495-3p TBL1X -1.47803501311999 6.88839745293927e-13 -0.197631988748507 0.233122599072657 mirMAP -0.121685828718881 0.000385213527103236 NA NA NA hsa-miR-539-5p TBL1X -0.15206998860136 0.492550733728996 -0.197631988748507 0.233122599072657 mirMAP -0.128990910068171 8.40930053715973e-05 NA NA NA hsa-miR-584-5p TBL1X 0.458655788667031 0.0421764547676754 -0.197631988748507 0.233122599072657 mirMAP -0.178792662011819 1.45821856754324e-08 NA NA NA hsa-miR-671-5p TBL1X 1.90920358947989 6.8158317757852e-31 -0.197631988748507 0.233122599072657 MirTarget -0.129631367172632 0.00161189545042971 NA NA NA hsa-miR-126-5p TBL1XR1 -0.953529188793816 7.91719143295591e-16 0.754842775980459 9.95107133728191e-15 MirTarget;mirMAP -0.162209063805421 5.61095133930666e-06 NA NA NA hsa-miR-140-3p TBL1XR1 -0.967453553824782 7.6999446305445e-23 0.754842775980459 9.95107133728191e-15 PITA -0.209763430922727 7.75207305413786e-07 NA NA NA hsa-miR-299-5p TBL1XR1 -1.92445654064493 1.52402531359074e-16 0.754842775980459 9.95107133728191e-15 MirTarget;miRNATAP -0.102277607272451 1.24520478753004e-08 NA NA NA hsa-miR-30d-3p TBL1XR1 -0.577371911152798 2.02950840095287e-06 0.754842775980459 9.95107133728191e-15 mirMAP -0.123935517551406 0.000517951852387332 NA NA NA hsa-miR-338-5p TBL1XR1 -1.71946558699173 2.62649071488641e-23 0.754842775980459 9.95107133728191e-15 PITA -0.112497384511907 2.63335519155142e-06 NA NA NA hsa-miR-24-2-5p TCF7L2 1.27293931700635 4.48240091510596e-15 -0.121670934720171 0.187175353769128 MirTarget -0.109017447605775 5.05328253504215e-06 NA NA NA hsa-miR-576-5p TCF7L2 0.940432050128373 6.90227595663302e-12 -0.121670934720171 0.187175353769128 mirMAP -0.109067218424977 0.000139070321050089 NA NA NA hsa-miR-27a-3p TP53 0.348456440505425 0.00126682892514312 -0.41755807197951 0.03001853518726 miRNAWalker2_validate -0.202518579356515 0.009421402460679 NA NA NA hsa-miR-106b-5p VANGL1 0.50378717276868 1.45412404526866e-05 0.246195163379457 0.025161652057206 miRNATAP -0.119443401257424 0.00369367103628316 NA NA NA hsa-miR-148a-3p VANGL1 -0.428944290834563 0.00954246923521465 0.246195163379457 0.025161652057206 mirMAP -0.105463849622244 0.000256308855366595 NA NA NA hsa-miR-19b-3p VANGL1 0.538732279378089 0.000622008277870679 0.246195163379457 0.025161652057206 mirMAP -0.159155408168371 1.18658578034853e-07 NA NA NA hsa-miR-218-5p VANGL1 -1.0725338636959 3.61493686604269e-09 0.246195163379457 0.025161652057206 mirMAP -0.176631578537942 4.09543962660159e-12 NA NA NA hsa-miR-26b-5p VANGL1 -0.254478038884324 0.0285227763044636 0.246195163379457 0.025161652057206 miRNAWalker2_validate;mirMAP -0.178850141233874 1.42856646437909e-05 NA NA NA hsa-miR-27b-3p VANGL1 -0.732682718863563 2.26896143573324e-09 0.246195163379457 0.025161652057206 miRNATAP -0.108468368804086 0.00502075936480855 NA NA NA hsa-miR-320a VANGL1 0.801356001806321 4.91397101474502e-09 0.246195163379457 0.025161652057206 mirMAP -0.160100861265277 3.11496057133194e-06 NA NA NA hsa-miR-374a-3p VANGL1 -0.299190081500425 0.00682975596757891 0.246195163379457 0.025161652057206 mirMAP -0.187644597838983 1.46106453949109e-05 NA NA NA hsa-miR-454-3p VANGL1 1.54137391927201 4.15861570449376e-20 0.246195163379457 0.025161652057206 mirMAP -0.102422985963695 0.000186608818199535 NA NA NA hsa-miR-590-5p VANGL1 0.763025362395968 3.65305892505623e-09 0.246195163379457 0.025161652057206 mirMAP -0.112261036650467 0.00215776614663086 NA NA NA hsa-miR-664a-3p VANGL1 -0.256108763664991 0.0513188660751664 0.246195163379457 0.025161652057206 mirMAP -0.211467447244251 4.76750901703883e-09 NA NA NA hsa-miR-9-5p VANGL1 1.65694862043766 2.08325802567323e-05 0.246195163379457 0.025161652057206 miRNATAP -0.104809070595655 5.61830196239753e-19 NA NA NA hsa-miR-93-5p VANGL1 1.61042951896619 5.1280369606967e-24 0.246195163379457 0.025161652057206 miRNATAP -0.113686495288259 7.13935443826298e-05 NA NA NA hsa-miR-139-5p VANGL2 -1.46099200329485 7.85040381494472e-22 0.557110439932697 0.00123817750760716 miRanda -0.183641940049093 0.000109307948725522 NA NA NA hsa-miR-140-3p VANGL2 -0.967453553824782 7.6999446305445e-23 0.557110439932697 0.00123817750760716 PITA;miRNATAP -0.240126071806401 0.0011697776960741 NA NA NA hsa-miR-146b-3p VANGL2 0.186534815310862 0.169137114997759 0.557110439932697 0.00123817750760716 PITA -0.221292899485026 6.91225143829201e-05 NA NA NA hsa-miR-186-5p VANGL2 0.353452958261612 0.000145058448579496 0.557110439932697 0.00123817750760716 mirMAP -0.302522399618752 0.0001994354285578 NA NA NA hsa-miR-26b-5p VANGL2 -0.254478038884324 0.0285227763044636 0.557110439932697 0.00123817750760716 miRNAWalker2_validate;MirTarget -0.212604239114184 0.00110387224225467 NA NA NA hsa-miR-30a-5p VANGL2 -1.79779915425811 1.93360169837799e-26 0.557110439932697 0.00123817750760716 mirMAP -0.123121398766576 0.00370527680968325 NA NA NA hsa-miR-3614-5p VANGL2 0.955957969488529 2.95347675446694e-05 0.557110439932697 0.00123817750760716 miRNATAP -0.107491985918805 0.00100657414515029 NA NA NA hsa-miR-362-5p VANGL2 0.41089772861323 0.0404254902071382 0.557110439932697 0.00123817750760716 mirMAP -0.100408731758483 0.0075748492275917 NA NA NA hsa-miR-495-3p VANGL2 -1.47803501311999 6.88839745293927e-13 0.557110439932697 0.00123817750760716 mirMAP -0.134726952895877 0.000167686657700494 NA NA NA hsa-miR-511-5p VANGL2 0.214339847118675 0.232372953100021 0.557110439932697 0.00123817750760716 MirTarget -0.228324885249339 4.16197722181855e-08 NA NA NA hsa-miR-582-3p VANGL2 -0.248056267546012 0.143798829508405 0.557110439932697 0.00123817750760716 mirMAP -0.132348591712164 0.00293137036069122 NA NA NA hsa-miR-590-3p VANGL2 0.221436901462551 0.0965904764063157 0.557110439932697 0.00123817750760716 miRanda -0.154408023581357 0.00658866228240596 NA NA NA hsa-miR-320a WIF1 0.801356001806321 4.91397101474502e-09 -4.8216454666485 8.30387178070846e-18 miRanda -0.472867874021515 0.00963088595562674 NA NA NA hsa-miR-330-5p WIF1 0.944693925383906 5.04972895657346e-13 -4.8216454666485 8.30387178070846e-18 miRanda -0.914953836061656 1.18094693506961e-06 NA NA NA hsa-miR-342-3p WIF1 0.99756868977753 9.28499866272332e-10 -4.8216454666485 8.30387178070846e-18 miRanda -0.650170665711913 1.92779756202269e-05 NA NA NA hsa-miR-590-3p WIF1 0.221436901462551 0.0965904764063157 -4.8216454666485 8.30387178070846e-18 PITA;miRanda;mirMAP -0.564518571101745 0.00303989284075106 NA NA NA hsa-miR-378a-3p WNT10A -1.50453783521372 9.41694954361173e-17 0.912234934100313 0.00299229216637372 MirTarget;miRNATAP -0.196810924541095 0.00626452857856093 NA NA NA hsa-miR-378c WNT10A -1.82618708894602 7.26454201089171e-22 0.912234934100313 0.00299229216637372 MirTarget;miRNATAP -0.214084791496156 0.00157458296095885 NA NA NA hsa-miR-320b WNT11 1.23473838180754 3.04337566045537e-14 -0.224750666322645 0.510626012221646 miRanda -0.270316259616059 0.0024603931714496 NA NA NA hsa-miR-429 WNT11 0.559451508722375 0.00563641638673083 -0.224750666322645 0.510626012221646 miRNATAP -0.209942515620557 0.00424611523018706 NA NA NA hsa-miR-590-3p WNT11 0.221436901462551 0.0965904764063157 -0.224750666322645 0.510626012221646 miRanda -0.501468167000306 6.77947598913954e-06 NA NA NA hsa-miR-146b-3p WNT16 0.186534815310862 0.169137114997759 -0.572594284105154 0.0847579131877057 MirTarget -0.378579455076714 0.000401262636265055 NA NA NA hsa-miR-181a-5p WNT16 0.819060835827404 1.38616688310277e-13 -0.572594284105154 0.0847579131877057 miRNAWalker2_validate;MirTarget -0.403564170104319 0.00167256717496098 NA NA NA hsa-miR-181b-5p WNT16 0.974255518824355 2.64876280203475e-16 -0.572594284105154 0.0847579131877057 MirTarget -0.455875596880539 0.000117206606772003 NA NA NA hsa-miR-139-5p WNT2 -1.46099200329485 7.85040381494472e-22 3.55309052838923 1.0938033286164e-22 miRanda -0.690199764489526 1.59848261634154e-11 NA NA NA hsa-miR-361-3p WNT2 0.272298288982435 0.0147874880476998 3.55309052838923 1.0938033286164e-22 MirTarget -0.431764780233256 0.00366253988360293 NA NA NA hsa-miR-362-3p WNT2 -0.697212068252854 2.61718493418184e-06 3.55309052838923 1.0938033286164e-22 miRanda -0.527767916132786 1.67420691006025e-06 NA NA NA hsa-miR-532-5p WNT2 -0.021857649390892 0.830992272120134 3.55309052838923 1.0938033286164e-22 miRNATAP -0.480782556995644 0.00315250264690939 NA NA NA hsa-miR-590-3p WNT2 0.221436901462551 0.0965904764063157 3.55309052838923 1.0938033286164e-22 miRanda;mirMAP -0.366105059605095 0.00323658686598995 NA NA NA hsa-miR-624-5p WNT2 -0.229389464626096 0.110488966509615 3.55309052838923 1.0938033286164e-22 MirTarget -0.448629777504243 9.83335360340784e-05 NA NA NA hsa-miR-125a-3p WNT2B 0.116035800853173 0.444825559956959 0.857364992918016 0.00177791017742915 miRanda -0.306887893905702 0.000102594071214014 NA NA NA hsa-miR-130a-3p WNT2B 0.67051191119964 4.89747518735144e-06 0.857364992918016 0.00177791017742915 MirTarget -0.231837953960532 0.00433670996478201 NA NA NA hsa-miR-186-5p WNT2B 0.353452958261612 0.000145058448579496 0.857364992918016 0.00177791017742915 mirMAP -0.502293042756746 0.000102724799757724 NA NA NA hsa-miR-576-5p WNT2B 0.940432050128373 6.90227595663302e-12 0.857364992918016 0.00177791017742915 mirMAP -0.256334036782699 0.00286460593846409 NA NA NA hsa-miR-135b-5p WNT3 1.5570143078477 4.60753610971455e-13 0.498299440798017 0.0228069128506682 MirTarget -0.143238430697911 0.000931984076340095 NA NA NA hsa-miR-146a-5p WNT3 -0.0201236699646614 0.905882759106561 0.498299440798017 0.0228069128506682 MirTarget -0.243184121621581 1.38485802464774e-05 NA NA NA hsa-miR-146b-5p WNT3 0.917975986853978 3.33749259316025e-09 0.498299440798017 0.0228069128506682 MirTarget;PITA;miRanda;miRNATAP -0.170568796363283 0.00496324388141207 NA NA NA hsa-miR-192-5p WNT3 0.380924502586635 0.00986961967409205 0.498299440798017 0.0228069128506682 miRNAWalker2_validate -0.222711795902267 0.000567479502332092 NA NA NA hsa-miR-215-5p WNT3 -0.757663683237828 5.72998183244808e-05 0.498299440798017 0.0228069128506682 miRNAWalker2_validate -0.165315446096867 0.0011006520087949 NA NA NA hsa-miR-107 WNT4 -0.0447040564279497 0.671618791096755 0.155343533272991 0.546942165628682 PITA;miRNATAP -0.442918090382549 3.50237250623185e-05 NA NA NA hsa-let-7a-3p WNT5A 0.0966652362351867 0.423761916840503 0.230244489186426 0.276036125068596 miRNATAP -0.236393902681147 0.00203160512009966 NA NA NA hsa-miR-142-3p WNT5A 1.12754191614028 1.68798138028946e-08 0.230244489186426 0.276036125068596 miRanda -0.170207296882227 0.000170819602841971 NA NA NA hsa-miR-155-5p WNT5A 0.533437622040649 0.00248671179205372 0.230244489186426 0.276036125068596 miRNAWalker2_validate;mirMAP -0.292461135450501 1.33940668925285e-08 NA NA NA hsa-miR-15b-3p WNT5A 1.05020782493504 6.38723677324836e-14 0.230244489186426 0.276036125068596 mirMAP -0.175165295991482 0.00645298447676834 NA NA NA hsa-miR-16-2-3p WNT5A 1.1567130855258 1.01867256952189e-14 0.230244489186426 0.276036125068596 MirTarget;mirMAP -0.335972431523505 1.53488293667871e-08 NA NA NA hsa-miR-16-5p WNT5A 0.521122945828175 1.40561786410572e-06 0.230244489186426 0.276036125068596 miRNAWalker2_validate -0.370382454158463 1.19067012660461e-05 NA NA NA hsa-miR-186-5p WNT5A 0.353452958261612 0.000145058448579496 0.230244489186426 0.276036125068596 miRNAWalker2_validate;mirMAP;miRNATAP -0.450879801993129 5.17906690047651e-06 NA NA NA hsa-miR-205-3p WNT5A 1.2960640797621 5.80786479909147e-11 0.230244489186426 0.276036125068596 mirMAP -0.146584017158563 0.00129989170721468 NA NA NA hsa-miR-26b-5p WNT5A -0.254478038884324 0.0285227763044636 0.230244489186426 0.276036125068596 mirMAP;miRNATAP -0.280915259189257 0.00040737667148347 NA NA NA hsa-miR-29a-5p WNT5A 0.323252792625584 0.0370417231222825 0.230244489186426 0.276036125068596 mirMAP -0.260976602260308 1.01644561078111e-05 NA NA NA hsa-miR-30a-3p WNT5A -2.26144364746452 8.12421214153823e-31 0.230244489186426 0.276036125068596 mirMAP -0.118105642486288 0.00756898976025631 NA NA NA hsa-miR-30a-5p WNT5A -1.79779915425811 1.93360169837799e-26 0.230244489186426 0.276036125068596 miRNAWalker2_validate;mirMAP -0.17873480778717 0.000544504752065439 NA NA NA hsa-miR-30b-5p WNT5A -0.400238605368173 0.00346540992719245 0.230244489186426 0.276036125068596 mirMAP -0.382501092288541 8.72466565087115e-09 NA NA NA hsa-miR-30c-5p WNT5A 0.021222006155897 0.886366656528128 0.230244489186426 0.276036125068596 mirMAP -0.315278604382802 3.20061386526904e-07 NA NA NA hsa-miR-30d-3p WNT5A -0.577371911152798 2.02950840095287e-06 0.230244489186426 0.276036125068596 mirMAP -0.330966437618027 1.06807407622655e-05 NA NA NA hsa-miR-30e-3p WNT5A -0.890635378639789 1.65740480611339e-16 0.230244489186426 0.276036125068596 mirMAP -0.32558124534923 8.6493574536442e-05 NA NA NA hsa-miR-30e-5p WNT5A -1.02114836019762 6.81961221797866e-17 0.230244489186426 0.276036125068596 mirMAP -0.302477702909968 3.39614513198558e-05 NA NA NA hsa-miR-330-5p WNT5A 0.944693925383906 5.04972895657346e-13 0.230244489186426 0.276036125068596 miRanda -0.29230342849594 2.09572746719721e-05 NA NA NA hsa-miR-374b-5p WNT5A -0.288413933608091 0.0041474558664058 0.230244489186426 0.276036125068596 MirTarget;miRNATAP -0.304076813996518 0.000947733080358778 NA NA NA hsa-miR-576-5p WNT5A 0.940432050128373 6.90227595663302e-12 0.230244489186426 0.276036125068596 mirMAP -0.285474332440034 1.36168151290682e-05 NA NA NA hsa-miR-582-5p WNT5A -0.0366995972742474 0.821827119138923 0.230244489186426 0.276036125068596 miRNATAP -0.165827000654824 0.00340576037437022 NA NA NA hsa-miR-590-3p WNT5A 0.221436901462551 0.0965904764063157 0.230244489186426 0.276036125068596 miRanda;mirMAP;miRNATAP -0.250968399301464 0.000285345561598827 NA NA NA hsa-miR-7-1-3p WNT5A 1.13646121619622 1.49823237535933e-14 0.230244489186426 0.276036125068596 mirMAP -0.288658318926048 1.72502648080357e-06 NA NA NA hsa-miR-92a-3p WNT5A 0.994679542307232 1.32587679156217e-16 0.230244489186426 0.276036125068596 miRNAWalker2_validate -0.244964920046973 0.00100835732123874 NA NA NA hsa-miR-185-5p WNT5B 0.675225177054909 1.84953949190805e-13 -0.860090527376287 0.000559437189686941 miRNAWalker2_validate -0.304303496296371 0.00959861548970579 NA NA NA hsa-miR-339-5p WNT5B 1.07771430326938 2.45772601859307e-09 -0.860090527376287 0.000559437189686941 miRanda -0.15836635732466 0.00779539351118663 NA NA NA hsa-miR-107 WNT7A -0.0447040564279497 0.671618791096755 2.17548841896822 1.27532651052268e-07 MirTarget;miRanda -0.704639231015142 4.76998312512393e-05 NA NA NA hsa-miR-15b-5p WNT7A 0.85315666454713 3.79816274836297e-12 2.17548841896822 1.27532651052268e-07 MirTarget -0.690990899099695 1.72630444936178e-06 27195958 WNT7A Regulation by miR 15b in Ovarian Cancer; In the present study we report that WNT7A is a direct target of miR-15b in ovarian cancer; We showed that a luciferase reporter containing the putative binding site of miR-15b in the WNT7A 3'-UTR was significantly repressed by miR-15b; Mutation of the putative binding site of miR-15b in the WNT7A 3'-UTR restored luciferase activity; Furthermore miR-15b was able to repress increased levels of TOPFLASH activity by WNT7A but not those induced by S33Y; Additionally miR-15b dose-dependently decreased WNT7A expression; When we evaluated the prognostic impact of WNT7A and miR-15b expression using TCGA datasets a significant inverse correlation in which high-expression of WNT7A and low-expression of miR-15b was associated with reduced survival rates of ovarian cancer patients; These results suggest that WNT7A is post-transcriptionally regulated by miR-15b which could be down-regulated by promoter hypermethylation potentially via DNMT1 in ovarian cancer poor survival ovarian cancer hsa-miR-16-5p WNT7A 0.521122945828175 1.40561786410572e-06 2.17548841896822 1.27532651052268e-07 MirTarget -0.727661930163233 1.31515331894387e-05 NA NA NA hsa-miR-195-5p WNT7A -1.8367376818177 6.9944883988895e-31 2.17548841896822 1.27532651052268e-07 MirTarget -0.420405764359272 8.98560350756301e-05 NA NA NA hsa-miR-361-5p WNT7A 0.0803683277369505 0.314043140368058 2.17548841896822 1.27532651052268e-07 MirTarget;PITA;miRanda -0.891722288618307 0.000113416001776986 NA NA NA hsa-miR-374a-3p WNT7A -0.299190081500425 0.00682975596757891 2.17548841896822 1.27532651052268e-07 MirTarget -0.782011644121057 1.84931464169463e-06 NA NA NA hsa-miR-3913-5p WNT7A 0.48532077857571 0.00112373589405304 2.17548841896822 1.27532651052268e-07 mirMAP -0.520316506606756 1.91652734520631e-05 NA NA NA hsa-miR-497-5p WNT7A -0.966244470847844 5.26505649147857e-12 2.17548841896822 1.27532651052268e-07 MirTarget -0.720047679687649 1.07500330892353e-08 NA NA NA hsa-miR-10b-5p WNT7B -0.582989331935508 4.56688330655626e-06 1.7004681714238 2.27477787935058e-17 mirMAP -0.254700491744119 0.000304932969815983 NA NA NA hsa-miR-30a-5p WNT7B -1.79779915425811 1.93360169837799e-26 1.7004681714238 2.27477787935058e-17 miRNATAP -0.466902672834237 1.18370343078737e-21 NA NA NA hsa-miR-30b-3p WNT7B -0.338530747940815 0.0223424741180399 1.7004681714238 2.27477787935058e-17 MirTarget;mirMAP -0.283717947694266 2.99907138520331e-06 NA NA NA hsa-miR-30c-5p WNT7B 0.021222006155897 0.886366656528128 1.7004681714238 2.27477787935058e-17 miRNATAP -0.248026630736634 4.49363608133385e-05 NA NA NA hsa-miR-30d-5p WNT7B -0.38399848121878 0.000171129616944749 1.7004681714238 2.27477787935058e-17 miRNATAP -0.387355730204942 1.12731679219259e-05 NA NA NA hsa-miR-326 WNT7B -0.425943992128769 0.0415010315530797 1.7004681714238 2.27477787935058e-17 MirTarget;miRanda -0.119317715803056 0.00592370357797529 NA NA NA hsa-miR-335-5p WNT7B -1.17227779671552 1.49282618530733e-10 1.7004681714238 2.27477787935058e-17 miRNAWalker2_validate -0.141127235729782 0.00359476145185812 NA NA NA hsa-miR-34a-5p WNT7B -0.117372471043915 0.364001947180738 1.7004681714238 2.27477787935058e-17 mirMAP -0.269459787758944 0.000117815770614211 NA NA NA hsa-miR-491-5p WNT7B -0.541680329196715 0.00135829217561865 1.7004681714238 2.27477787935058e-17 mirMAP -0.348417330977353 2.25675990553943e-10 NA NA NA hsa-miR-625-5p WNT7B 0.346770617079364 0.02860843739549 1.7004681714238 2.27477787935058e-17 mirMAP -0.311725290258202 4.06166953104253e-08 NA NA NA hsa-miR-664a-5p WNT7B -0.871809752100072 1.86842520324979e-08 1.7004681714238 2.27477787935058e-17 MirTarget -0.253065515953095 1.05052879457149e-05 NA NA NA hsa-miR-15a-5p WNT9A 0.783550182002274 2.60699595655907e-11 0.0990422421950703 0.673719860085433 mirMAP -0.493676321995247 6.0001956226427e-09 NA NA NA hsa-miR-193a-3p WNT9A 0.22120710726779 0.111827069464729 0.0990422421950703 0.673719860085433 mirMAP -0.283682307500411 0.000116395150642507 NA NA NA hsa-miR-363-3p WNT9A -0.608157508016978 0.0186109501272176 0.0990422421950703 0.673719860085433 mirMAP -0.150225234310504 0.000136888013162778 NA NA NA hsa-miR-589-3p WNT9A 1.59559692667315 6.2886410639161e-15 0.0990422421950703 0.673719860085433 mirMAP -0.208956780331595 3.5202221831103e-05 NA NA NA