miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p APC2 -0.328069937201898 0.000464344093744051 1.72078641102954 8.65364092042936e-19 TargetScan -0.296144411661104 0.00537712418099154 NA NA NA hsa-miR-185-3p APC2 -0.270845540360709 0.0853959272273836 1.72078641102954 8.65364092042936e-19 MirTarget -0.128016984954642 0.042723463729063 NA NA NA hsa-let-7g-3p AXIN2 -1.14091000722297 8.32736018188759e-19 0.113841868770703 0.752977397700815 MirTarget -0.333163518873582 0.0112609172880632 NA NA NA hsa-miR-15b-5p AXIN2 0.230566941413564 0.0824765001857479 0.113841868770703 0.752977397700815 MirTarget -0.445214007102522 0.000810754926318775 NA NA NA hsa-miR-16-5p AXIN2 -0.398577235179603 0.000101598495180191 0.113841868770703 0.752977397700815 MirTarget -0.492511513287746 0.00421170477125135 NA NA NA hsa-miR-195-5p AXIN2 -1.85907534356434 1.47434041676402e-22 0.113841868770703 0.752977397700815 MirTarget -0.245874041969712 0.00506110437798971 NA NA NA hsa-miR-26b-3p AXIN2 -1.25503731613309 4.45390890119649e-27 0.113841868770703 0.752977397700815 MirTarget -0.591476065389494 2.94301063245798e-05 NA NA NA hsa-miR-424-5p AXIN2 -2.62653257498508 2.38997974737991e-50 0.113841868770703 0.752977397700815 MirTarget -0.191832991796132 0.0301808709524209 NA NA NA hsa-miR-497-5p AXIN2 -1.41371173021948 7.09278946477743e-17 0.113841868770703 0.752977397700815 MirTarget -0.294042209891213 0.00328690230713159 NA NA NA hsa-miR-616-3p AXIN2 -0.699516741506971 1.82225985970292e-05 0.113841868770703 0.752977397700815 MirTarget -0.422833368838949 7.60561180413777e-05 NA NA NA hsa-miR-15b-5p BTRC 0.230566941413564 0.0824765001857479 -0.00218074865097106 0.976713248009905 MirTarget -0.123880101738054 4.9294638073766e-06 NA NA NA hsa-miR-16-5p BTRC -0.398577235179603 0.000101598495180191 -0.00218074865097106 0.976713248009905 MirTarget -0.170550874702878 1.08874294937544e-06 NA NA NA hsa-miR-193a-3p BTRC -0.117675551589896 0.309391958208578 -0.00218074865097106 0.976713248009905 MirTarget -0.149422822918282 1.65168232460744e-06 NA NA NA hsa-miR-361-3p BTRC 0.275658012727111 0.00549374744374488 -0.00218074865097106 0.976713248009905 MirTarget -0.103082226711992 0.00494622838999385 NA NA NA hsa-miR-497-5p BTRC -1.41371173021948 7.09278946477743e-17 -0.00218074865097106 0.976713248009905 MirTarget -0.112851166430765 2.51720614567891e-08 NA NA NA hsa-miR-505-3p BTRC -1.20027021591555 1.27927500175937e-13 -0.00218074865097106 0.976713248009905 MirTarget -0.125291265362961 4.21412050838456e-09 NA NA NA hsa-miR-26b-3p CACYBP -1.25503731613309 4.45390890119649e-27 0.94781485840537 1.49218864384581e-19 MirTarget -0.260917629528483 7.49351372249007e-10 NA NA NA hsa-miR-30a-3p CACYBP -1.52720594401486 1.3830066075708e-17 0.94781485840537 1.49218864384581e-19 MirTarget -0.221395044532441 1.38042138996782e-15 NA NA NA hsa-miR-30e-3p CACYBP -1.20845647373031 3.10263633528203e-25 0.94781485840537 1.49218864384581e-19 MirTarget -0.346714737260252 1.1672915775241e-16 NA NA NA hsa-miR-21-3p CAMK2A -0.484219378716006 0.00299941098417659 -0.327454379942138 0.356907439672438 MirTarget -0.428695676613169 4.7255606363298e-05 NA NA NA hsa-miR-25-3p CAMK2A 0.633062563556379 3.68686354834328e-10 -0.327454379942138 0.356907439672438 MirTarget -0.353714687940178 0.0371404712484319 NA NA NA hsa-miR-7-1-3p CAMK2A -0.569105143287799 1.85297665041424e-05 -0.327454379942138 0.356907439672438 MirTarget -0.357336167957049 0.00584245749670331 NA NA NA hsa-miR-589-3p CAMK2B 1.16846704028095 5.88525574424201e-11 -3.79443915567367 4.19182064533683e-17 MirTarget -0.778879183962213 6.21351266377714e-10 NA NA NA hsa-miR-1976 CAMK2G -0.431472440543166 0.00324575010550946 0.576340676979716 4.27895494044483e-14 MirTarget -0.102016754320286 8.34056004410933e-05 NA NA NA hsa-miR-30e-3p CAMK2G -1.20845647373031 3.10263633528203e-25 0.576340676979716 4.27895494044483e-14 MirTarget -0.11996903246946 0.000104033180079318 NA NA NA hsa-miR-628-5p CAMK2G -0.714131904567584 3.9911900261429e-08 0.576340676979716 4.27895494044483e-14 MirTarget -0.106189345393338 0.000243038442100515 NA NA NA hsa-miR-106a-5p CCND1 -0.464229535269236 0.009724944358047 -0.901747452525989 1.22363850855738e-05 MirTarget -0.262282596122017 2.76721397734651e-06 NA NA NA hsa-miR-106b-5p CCND1 0.648901865047099 8.24870862047885e-09 -0.901747452525989 1.22363850855738e-05 MirTarget -0.430796355484411 1.07010119372681e-06 NA NA NA hsa-miR-1266-5p CCND1 1.6344248374643 4.09278929749906e-13 -0.901747452525989 1.22363850855738e-05 MirTarget -0.234489057674296 5.64471200142146e-08 NA NA NA hsa-miR-15b-5p CCND1 0.230566941413564 0.0824765001857479 -0.901747452525989 1.22363850855738e-05 MirTarget -0.544455359613115 3.17021042565567e-13 NA NA NA hsa-miR-16-5p CCND1 -0.398577235179603 0.000101598495180191 -0.901747452525989 1.22363850855738e-05 MirTarget -0.309506657035983 0.00178218906910022 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-17-5p CCND1 0.698861147045461 2.43854106455398e-05 -0.901747452525989 1.22363850855738e-05 MirTarget;TargetScan -0.343463418912801 9.97512783987264e-09 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene breast cancer hsa-miR-193a-3p CCND1 -0.117675551589896 0.309391958208578 -0.901747452525989 1.22363850855738e-05 MirTarget -0.209180766181781 0.0180609153505735 NA NA NA hsa-miR-20a-5p CCND1 0.854326758727003 5.04256669663285e-07 -0.901747452525989 1.22363850855738e-05 MirTarget -0.332506713675419 1.04479750525145e-08 NA NA NA hsa-miR-20b-5p CCND1 0.457668023910379 0.0285865211936156 -0.901747452525989 1.22363850855738e-05 MirTarget -0.230429652941375 1.603682834845e-06 NA NA NA hsa-miR-503-5p CCND1 0.191949282338049 0.268420664548092 -0.901747452525989 1.22363850855738e-05 MirTarget -0.155187994375291 0.00815133470022587 26047605;23731275 MiR 503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression; Overexpression of miR-503 in breast cancer cell lines reduced cell proliferation through inducing G0/G1 cell cycle arrest by targeting CCND1;MicroRNA 503 suppresses proliferation and cell cycle progression of endometrioid endometrial cancer by negatively regulating cyclin D1; CCND1 has a binding sequence of miR-503 within its 3' untranslated region and was confirmed to be a direct target of miR-503 by the fluorescent reporter assays; Increasing the miR-503 level in EEC cells suppressed cell viability colon formation activity and cell-cycle progression and the inhibited oncogenic phenotypes induced by miR-503 were alleviated by ectopic expression of CCND1 without the untranslated region sequence; Collectively this study suggested that miR-503 plays a tumor-suppressor role by targeting CCND1; Abnormal suppression of miR-503 leads to an increase in the CCND1 level which may promote carcinogenesis and progression of EEC ;progression;tumorigenesis breast cancer;endometrial cancer hsa-miR-589-3p CCND1 1.16846704028095 5.88525574424201e-11 -0.901747452525989 1.22363850855738e-05 MirTarget -0.183119037529565 0.00124255651400669 NA NA NA hsa-miR-93-5p CCND1 1.39518349670953 2.84167728726712e-25 -0.901747452525989 1.22363850855738e-05 MirTarget -0.335918242999821 2.01286203755089e-06 NA NA NA hsa-miR-942-5p CCND1 0.346451845105263 0.0283255399972342 -0.901747452525989 1.22363850855738e-05 MirTarget -0.245807225430864 0.000123103109119178 NA NA NA hsa-miR-17-5p CCND2 0.698861147045461 2.43854106455398e-05 0.356451160382274 0.0365641518216489 TargetScan -0.113015688947626 0.0235787855141743 NA NA NA hsa-miR-19b-3p CCND2 0.601279551368824 0.00016685097085251 0.356451160382274 0.0365641518216489 MirTarget -0.119904158273959 0.0208215571869961 NA NA NA hsa-miR-33a-3p CCND2 -0.683025859637737 1.01106097756419e-05 0.356451160382274 0.0365641518216489 MirTarget -0.263538375258973 6.17940317063527e-07 NA NA NA hsa-miR-548v CCND2 -0.27258775900243 0.176259917595269 0.356451160382274 0.0365641518216489 MirTarget -0.149460521918892 0.000339780804187451 NA NA NA hsa-miR-501-3p CSNK1A1 0.999540908940094 2.77358485581974e-11 -0.337358696279789 1.0388780822195e-09 TargetScan -0.104354920023566 2.1202153173049e-09 NA NA NA hsa-miR-125b-5p CSNK2A1 -1.35767721102906 1.16564617395164e-18 0.311613292322925 6.17228757339028e-05 MirTarget -0.149030754925627 1.35154941408146e-10 NA NA NA hsa-miR-618 CTBP2 0.13539895350352 0.517145913114103 -0.39317918949034 0.0225071278697855 MirTarget -0.334800818337328 8.46589457931172e-17 NA NA NA hsa-miR-330-3p CTNNB1 -0.332364259424489 0.0316051913061459 0.00180452674840392 0.983564078864382 MirTarget -0.128940103294471 3.76576237893285e-06 NA NA NA hsa-miR-23a-3p CTNNBIP1 -0.178875974460574 0.135978273540604 0.14023231220123 0.147963042657645 MirTarget -0.189688066747386 1.24474286715309e-06 NA NA NA hsa-miR-29a-3p CTNNBIP1 -0.856762511178136 4.65330336378459e-12 0.14023231220123 0.147963042657645 MirTarget -0.128675201414392 0.00052389516655892 NA NA NA hsa-miR-130b-3p DAAM1 0.687190305027546 0.000109068658562255 -0.820319075229238 3.16122030911227e-05 MirTarget -0.230438739665998 1.89403317991823e-05 NA NA NA hsa-miR-130b-5p DAAM1 0.170599813152408 0.337611586432771 -0.820319075229238 3.16122030911227e-05 MirTarget -0.133084117469404 0.014855813976074 NA NA NA hsa-miR-183-5p DAAM1 2.33444328833177 1.52188109365421e-10 -0.820319075229238 3.16122030911227e-05 MirTarget -0.109601186169797 2.10092575174277e-05 NA NA NA hsa-miR-301a-3p DAAM1 0.842910511640361 1.43446467417891e-06 -0.820319075229238 3.16122030911227e-05 MirTarget -0.221373325761519 4.89015141234831e-05 NA NA NA hsa-miR-362-3p DAAM1 0.814007335895913 2.00108618836568e-09 -0.820319075229238 3.16122030911227e-05 MirTarget -0.19953143276621 0.00451703685771936 NA NA NA hsa-miR-452-5p DAAM1 1.91544498799508 1.81995982853313e-14 -0.820319075229238 3.16122030911227e-05 MirTarget -0.128524206630459 0.000583790339994043 NA NA NA hsa-miR-500a-3p DAAM1 1.18913245435489 1.59516890341346e-16 -0.820319075229238 3.16122030911227e-05 MirTarget -0.172185465678666 0.00798226327576634 NA NA NA hsa-miR-548j-5p DAAM1 0.251239647701947 0.171361975450222 -0.820319075229238 3.16122030911227e-05 MirTarget -0.195072210611623 0.000335073361311463 NA NA NA hsa-miR-29b-2-5p DVL3 -0.223258653034772 0.084306146519938 0.609321698955873 3.59083763972193e-15 MirTarget -0.104468815670416 0.000526336007952701 NA NA NA hsa-miR-22-3p EP300 -0.628561621952407 1.33755558015523e-09 -0.200382966790078 0.0704945874784134 MirTarget -0.102672783880902 0.0463193353503437 NA NA NA hsa-miR-30d-3p EP300 -0.120562286038759 0.329549534782125 -0.200382966790078 0.0704945874784134 MirTarget -0.106915117943506 0.0149374124449437 NA NA NA hsa-miR-342-3p EP300 -0.319677314984262 0.0449813878317147 -0.200382966790078 0.0704945874784134 MirTarget -0.112632997815777 0.000853079257159957 NA NA NA hsa-miR-16-1-3p FBXW11 0.392360028038559 0.00112481918108198 0.0471132174286888 0.541930794061236 MirTarget -0.108794263042156 0.000448893797575061 NA NA NA hsa-miR-19a-3p FOSL1 1.01712596153672 2.57753201450625e-07 -1.28809880442401 1.10466405136613e-07 MirTarget -0.172041574882293 0.00411622412360713 23831570 MicroRNA 19a 3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra 1 proto oncogene; In addition we could measure the activity of binding between miR-19a-3p and Fra-1 with a psiCHECK luciferase reporter system; Taken together these findings indicate that miR-19a-3p is capable of downregulating the M2 phenotype in M2 macrophages and that the low expression of this miRNA has an important role in the upregulation of Fra-1 expression and induction of M2 macrophage polarization metastasis;progression breast cancer hsa-miR-19b-3p FOSL1 0.601279551368824 0.00016685097085251 -1.28809880442401 1.10466405136613e-07 MirTarget -0.20838470159538 0.00535183413101081 NA NA NA hsa-miR-22-3p FRAT2 -0.628561621952407 1.33755558015523e-09 0.225546147167742 0.0512402780577874 MirTarget -0.232862193711047 1.27800322792138e-05 NA NA NA hsa-miR-146b-5p FZD1 0.419719546795449 0.0457375823220155 -0.990655512447529 2.10933438723933e-07 MirTarget -0.181547752240403 4.76064172222519e-05 NA NA NA hsa-miR-616-5p FZD2 0.150569904638223 0.402836556304524 0.407208233535239 0.0755693801228699 MirTarget -0.338122672996804 3.93516371913571e-08 NA NA NA hsa-miR-107 FZD3 0.241662461253461 0.0170788899505389 -0.431602727356764 0.0760494397449049 MirTarget -0.328401554754828 0.0054060803500497 NA NA NA hsa-miR-17-5p FZD3 0.698861147045461 2.43854106455398e-05 -0.431602727356764 0.0760494397449049 MirTarget;TargetScan -0.236272506444877 0.000871018931823823 NA NA NA hsa-miR-20a-5p FZD3 0.854326758727003 5.04256669663285e-07 -0.431602727356764 0.0760494397449049 MirTarget -0.263395197675831 0.000124585706310954 NA NA NA hsa-miR-23b-3p FZD3 -0.530561587109023 5.43807206823652e-07 -0.431602727356764 0.0760494397449049 MirTarget -0.264478922308601 0.0178497249104268 NA NA NA hsa-miR-30b-3p FZD3 -0.439724365151373 0.000947180503583586 -0.431602727356764 0.0760494397449049 MirTarget -0.24731920299484 0.00552723242526519 NA NA NA hsa-miR-30d-5p FZD3 0.718283816348023 2.47422074061352e-08 -0.431602727356764 0.0760494397449049 MirTarget -0.251555607321146 0.00569090251961539 NA NA NA hsa-miR-30e-5p FZD3 -0.627815042856657 3.02205690184908e-10 -0.431602727356764 0.0760494397449049 MirTarget -0.313017658821363 0.00780190229296611 NA NA NA hsa-miR-3170 FZD3 -0.490667754008914 0.0102869987033346 -0.431602727356764 0.0760494397449049 MirTarget -0.129762933069345 0.0396673291425133 NA NA NA hsa-let-7d-5p FZD4 0.0503292020123807 0.702580311853671 -0.346477770504521 0.0109747315056824 MirTarget -0.118288031351343 0.0198943536737446 NA NA NA hsa-miR-17-3p FZD4 0.410352776142368 0.00422200500748636 -0.346477770504521 0.0109747315056824 MirTarget -0.252002356659912 3.55104649644788e-08 NA NA NA hsa-miR-17-5p FZD4 0.698861147045461 2.43854106455398e-05 -0.346477770504521 0.0109747315056824 TargetScan -0.299061948789719 9.79518944458252e-15 NA NA NA hsa-miR-185-5p FZD4 0.480006257154717 6.35758891340152e-07 -0.346477770504521 0.0109747315056824 MirTarget -0.200083841875822 0.00363439169236857 NA NA NA hsa-miR-3127-5p FZD4 0.837385386388614 2.06679743975142e-07 -0.346477770504521 0.0109747315056824 MirTarget -0.176968510712896 1.23416560759146e-05 NA NA NA hsa-miR-98-5p FZD4 -0.0487189107419432 0.715911066732548 -0.346477770504521 0.0109747315056824 MirTarget -0.103807475955208 0.0380444515679092 NA NA NA hsa-miR-101-3p FZD6 -1.48176407980989 3.98950707385704e-31 0.589500198001939 0.00374127878510925 MirTarget -0.312670748498135 1.38907823475328e-05 NA NA NA hsa-miR-194-5p FZD6 -0.292530160992458 0.0996141384876663 0.589500198001939 0.00374127878510925 MirTarget -0.265420163621645 1.75074747054336e-06 NA NA NA hsa-miR-30c-1-3p FZD7 -1.39373825444537 6.39912952911454e-17 -0.284533887049024 0.256557978536031 MirTarget -0.242705306431575 0.000670205498648697 NA NA NA hsa-miR-501-5p JUN 1.15231083477882 2.98906150004088e-10 -1.59869078760734 2.2999762521731e-23 MirTarget -0.201525326742419 4.62918338980132e-06 NA NA NA hsa-miR-23a-3p LRP5 -0.178875974460574 0.135978273540604 -0.425686510899649 0.000372958337957916 MirTarget -0.166260660405269 0.000692486268247638 NA NA NA hsa-miR-30d-3p MAP3K7 -0.120562286038759 0.329549534782125 0.0227052645956216 0.800739743576642 MirTarget -0.152801707733114 1.47792797573938e-05 NA NA NA hsa-miR-107 NFAT5 0.241662461253461 0.0170788899505389 -0.326144498869474 0.00164314559569324 MirTarget -0.115722218242209 0.0216894104295148 NA NA NA hsa-miR-192-3p NFAT5 -0.6401165114007 0.000266272092403814 -0.326144498869474 0.00164314559569324 MirTarget -0.128669502769738 6.06524882230981e-06 NA NA NA hsa-miR-30d-5p NFAT5 0.718283816348023 2.47422074061352e-08 -0.326144498869474 0.00164314559569324 MirTarget -0.100982909052041 0.00926486855231398 NA NA NA hsa-miR-548j-5p NFAT5 0.251239647701947 0.171361975450222 -0.326144498869474 0.00164314559569324 MirTarget -0.114891906111678 4.99601526011913e-05 NA NA NA hsa-miR-30d-5p NFATC2 0.718283816348023 2.47422074061352e-08 -1.87041062792181 1.43414339850833e-07 MirTarget -0.429558488883224 0.00143308759494954 NA NA NA hsa-miR-15a-5p NFATC3 0.349521211668244 0.000770735998804736 -0.644444487566839 5.42635056668801e-13 MirTarget -0.140535010330653 0.0011067840013694 NA NA NA hsa-miR-185-5p NFATC3 0.480006257154717 6.35758891340152e-07 -0.644444487566839 5.42635056668801e-13 MirTarget -0.179084861620697 0.000100696521869942 NA NA NA hsa-miR-222-3p NFATC3 1.08574156066353 1.76407192348131e-11 -0.644444487566839 5.42635056668801e-13 MirTarget -0.132741702448246 6.9873783779618e-07 NA NA NA hsa-miR-30d-5p NFATC3 0.718283816348023 2.47422074061352e-08 -0.644444487566839 5.42635056668801e-13 MirTarget -0.107813608303496 0.00162247650109074 NA NA NA hsa-miR-200b-3p NKD1 -1.29335788099229 0.000268623234305059 0.620599204750343 0.186026311634854 TargetScan -0.177575800556816 0.00545052296927983 NA NA NA hsa-miR-140-5p NLK -0.220106443070144 0.0140713197101242 0.22134800606754 0.00116385654486987 MirTarget -0.103530034440285 0.00564970191186252 NA NA NA hsa-miR-23a-3p NLK -0.178875974460574 0.135978273540604 0.22134800606754 0.00116385654486987 MirTarget -0.179303032195093 4.45306067895512e-11 NA NA NA hsa-miR-511-5p NLK -1.75067415533112 3.37801163573342e-23 0.22134800606754 0.00116385654486987 MirTarget -0.104612392627311 2.15162536528134e-09 NA NA NA hsa-miR-940 PPP2CB 0.453020092551484 0.0177054921651997 -0.890331286940364 2.58768297455211e-18 MirTarget -0.108413768942713 9.39010367602326e-05 NA NA NA hsa-miR-15a-5p PPP2R1B 0.349521211668244 0.000770735998804736 -0.366373279268895 0.0120240053013953 MirTarget -0.149129894906409 0.0304654709530036 NA NA NA hsa-miR-15b-5p PPP2R1B 0.230566941413564 0.0824765001857479 -0.366373279268895 0.0120240053013953 MirTarget -0.166547119923006 0.0019576167364681 NA NA NA hsa-miR-744-3p PPP2R1B -0.866026958622846 2.43034431433797e-08 -0.366373279268895 0.0120240053013953 MirTarget -0.151341218126979 0.000790301774844116 NA NA NA hsa-miR-197-3p PPP2R5A -0.245033899783728 0.0362223947695203 0.367967554039328 0.000201292409757339 MirTarget -0.159858222331069 0.000114867261240145 NA NA NA hsa-miR-1976 PPP2R5D -0.431472440543166 0.00324575010550946 0.490236074781638 1.12387325087843e-09 MirTarget -0.112669007651945 3.03261127309582e-05 NA NA NA hsa-miR-19b-3p PPP2R5E 0.601279551368824 0.00016685097085251 -0.33926942209527 0.000598805950355048 MirTarget -0.105521131212065 0.000437479384635745 NA NA NA hsa-miR-30d-3p PPP2R5E -0.120562286038759 0.329549534782125 -0.33926942209527 0.000598805950355048 MirTarget -0.120884932247343 0.0020877492288168 NA NA NA hsa-miR-17-3p PPP3CA 0.410352776142368 0.00422200500748636 -0.536165287387848 2.77787023947662e-11 MirTarget -0.148715997251777 6.8452735631761e-08 NA NA NA hsa-miR-501-3p PPP3CA 0.999540908940094 2.77358485581974e-11 -0.536165287387848 2.77787023947662e-11 MirTarget -0.169069809996199 3.5765991379194e-11 NA NA NA hsa-miR-502-3p PPP3CA 0.659598854007546 3.01316453996423e-08 -0.536165287387848 2.77787023947662e-11 MirTarget -0.21026132041502 1.15384439121552e-10 NA NA NA hsa-miR-589-3p PPP3CA 1.16846704028095 5.88525574424201e-11 -0.536165287387848 2.77787023947662e-11 MirTarget -0.121264895830011 4.18270966031286e-08 NA NA NA hsa-miR-106b-5p PPP3R1 0.648901865047099 8.24870862047885e-09 -0.348267739030591 8.30932335829799e-08 MirTarget -0.138661227962938 5.82082557526804e-07 NA NA NA hsa-miR-181a-5p PPP3R1 0.250113435902954 0.0551933249319293 -0.348267739030591 8.30932335829799e-08 MirTarget -0.13691462952235 1.55708164198961e-08 NA NA NA hsa-miR-181b-5p PPP3R1 0.488256489401108 0.00105321129419701 -0.348267739030591 8.30932335829799e-08 MirTarget -0.13726473522507 5.36198845965272e-11 NA NA NA hsa-miR-181c-5p PPP3R1 -0.00639394152050299 0.969127212255928 -0.348267739030591 8.30932335829799e-08 MirTarget -0.116625763794141 9.00795108119744e-10 NA NA NA hsa-miR-93-5p PPP3R1 1.39518349670953 2.84167728726712e-25 -0.348267739030591 8.30932335829799e-08 MirTarget -0.108796059262154 9.63915967695639e-07 NA NA NA hsa-miR-148a-3p PRICKLE2 -0.748702855596996 3.93313343865641e-07 -1.36375835552812 1.67599789165395e-08 MirTarget -0.361824889511995 5.66694348602003e-06 NA NA NA hsa-miR-148b-3p PRICKLE2 0.266862251671911 0.00185271302045935 -1.36375835552812 1.67599789165395e-08 MirTarget -0.463580487018835 0.00102384966132943 NA NA NA hsa-miR-21-5p PRICKLE2 1.51084295924322 1.54551622173259e-34 -1.36375835552812 1.67599789165395e-08 MirTarget -0.234850115033432 0.00889222361721155 NA NA NA hsa-miR-374a-3p PRICKLE2 -0.207171354826929 0.0623494608399903 -1.36375835552812 1.67599789165395e-08 MirTarget -0.268372531764719 0.0135953973446289 NA NA NA hsa-miR-589-5p PRICKLE2 1.18593770505086 1.01781241960531e-22 -1.36375835552812 1.67599789165395e-08 MirTarget -0.537211352042197 7.52017218056411e-09 NA NA NA hsa-miR-17-5p PRKACB 0.698861147045461 2.43854106455398e-05 -0.439902334736784 5.50105175875769e-05 TargetScan -0.144472658686219 5.56449338176546e-06 NA NA NA hsa-miR-19b-3p PRKACB 0.601279551368824 0.00016685097085251 -0.439902334736784 5.50105175875769e-05 MirTarget -0.115986971473871 0.00048141723506022 NA NA NA hsa-miR-361-5p PRKCB 0.233202959858696 0.00961572812255327 -1.62067363753233 3.76201992658756e-13 MirTarget -0.424918272347972 0.000711090604030861 NA NA NA hsa-miR-128-3p PRKX 0.289735108018712 0.0114419474207889 -0.240211607134995 0.240371070351319 MirTarget -0.177065931374921 0.0432124195545335 NA NA NA hsa-miR-148a-3p PRKX -0.748702855596996 3.93313343865641e-07 -0.240211607134995 0.240371070351319 MirTarget -0.590431480469924 2.08013051455884e-20 NA NA NA hsa-miR-16-1-3p PRKX 0.392360028038559 0.00112481918108198 -0.240211607134995 0.240371070351319 MirTarget -0.244568911489674 0.00313195084634789 NA NA NA hsa-miR-101-3p RAC1 -1.48176407980989 3.98950707385704e-31 0.216579201672401 0.00293326905874306 MirTarget -0.160619583159355 2.13421294167009e-10 25202416;24649082;25057058 In previous studies the role of miRNA-101 miR-101 in tumors has been identified as a tumor suppressor and until now the role of miR-101 and Rac1 in thyroid cancer has remained undefined; Rac1 was demonstrated to be negatively regulated by miR-101 at the post-transcriptional level via a specific target site within the 3' untranslated region by dual-luciferase reporter assay; The expression of Rac1 was also observed to inversely correlate with miR-101 expression in PTC tissues; knockdown of Rac1 by shRNA inhibited thyroid cancer cell migration and invasion resembling that of miR-101 overexpression; Thus these findings suggested that miR-101 acts as a novel suppressor by targeting the Rac1 gene and inhibiting thyroid cancer cell migration and invasion;miR 101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma; In the present study we investigated the role of microRNA-101 miR-101 in PTC via targeting of Ras-related C3 botulinum toxin substrate 1 Rac1; Moreover algorithm-based and experimental strategies verified Rac1 as a direct target of miR-101 in the K1 cell line; Taken together these findings suggest that miR-101 inhibited PTC growth via the downregulation of Rac1 expression providing a better understanding of miRNA-modulated signaling networks for future cancer therapeutics;Mir-101 inhibitors significantly increased the luciferase activities of RAC1 3'UTR; Overexpression of mir-101 increased the expression of RAC1 while inhibition of mir-101 suppressed RAC1 expression; mir-101 can suppress RAC1 gene expression by targeting the specific sequence of RAC1 3'UTR cell migration;; thyroid cancer;thyroid cancer;colorectal cancer hsa-miR-324-5p ROCK1 0.372933276649782 0.00592280066108904 -0.264366618624451 0.00575875249305368 MirTarget -0.132464043588386 0.000113488217308036 NA NA NA hsa-miR-17-5p ROCK2 0.698861147045461 2.43854106455398e-05 -0.343723141838983 0.0978147147700846 TargetScan -0.230848684676223 0.000132737616833034 NA NA NA hsa-miR-1301-3p SFRP1 1.12156714169769 4.22404125385203e-10 -4.14637823674297 1.04005427998815e-32 MirTarget -0.326166528078997 0.00113518434436241 NA NA NA hsa-miR-146b-5p SFRP1 0.419719546795449 0.0457375823220155 -4.14637823674297 1.04005427998815e-32 MirTarget -0.215066445935128 0.0140810441727555 NA NA NA hsa-miR-16-1-3p SFRP1 0.392360028038559 0.00112481918108198 -4.14637823674297 1.04005427998815e-32 MirTarget -0.71551742776429 2.38771391079108e-06 NA NA NA hsa-miR-192-3p SFRP1 -0.6401165114007 0.000266272092403814 -4.14637823674297 1.04005427998815e-32 MirTarget -0.424962367232444 4.17845072192868e-05 NA NA NA hsa-miR-548j-5p SFRP1 0.251239647701947 0.171361975450222 -4.14637823674297 1.04005427998815e-32 MirTarget -0.453370953209203 1.05214745425183e-05 NA NA NA hsa-miR-940 SFRP1 0.453020092551484 0.0177054921651997 -4.14637823674297 1.04005427998815e-32 MirTarget -0.248779732986302 0.0121273033245209 NA NA NA hsa-miR-144-5p SFRP4 -1.54604938792018 1.06886492586611e-10 2.13318024807939 8.83329524470029e-10 MirTarget -0.351626376323752 4.90563413861651e-07 NA NA NA hsa-miR-3607-3p SFRP4 -2.15518588554493 1.03390728226728e-23 2.13318024807939 8.83329524470029e-10 MirTarget -0.343276705360189 5.59321744727563e-06 NA NA NA hsa-miR-532-5p SFRP4 1.02729546510601 9.93318913966636e-16 2.13318024807939 8.83329524470029e-10 MirTarget -0.271814490134315 0.0386462407402257 NA NA NA hsa-miR-7-1-3p SKP1 -0.569105143287799 1.85297665041424e-05 0.220350434523828 0.00211239594525225 MirTarget -0.109724018574561 2.33101260912259e-05 NA NA NA hsa-miR-1976 SMAD3 -0.431472440543166 0.00324575010550946 0.313849246286883 0.00280528337161062 MirTarget -0.177460759581402 2.8140086065009e-07 NA NA NA hsa-miR-424-5p SMAD3 -2.62653257498508 2.38997974737991e-50 0.313849246286883 0.00280528337161062 MirTarget -0.105846554796035 3.45471115916176e-05 27655675 miR 424 5p promotes proliferation of gastric cancer by targeting Smad3 through TGF β signaling pathway; QRT-PCR was used to determine the expression levels of miR-424-5p and Smad3; Luciferase reporter assay and western blotting were used to prove that Smad3 was one of the direct targets of miR-424-5p; In addition luciferase reporter assay and western blotting assay revealed that Smad3 was a direct target of miR-424-5p; Over-expression of Smad3 could partially reverse the effects of miR-424-5p on GC cell proliferation; Our study further revealed that miR-424-5p could inhibit TGF-β signaling pathway by Smad3 gastric cancer hsa-miR-29b-2-5p SMAD4 -0.223258653034772 0.084306146519938 -0.30976054630181 7.55983294717014e-05 MirTarget -0.1066651080199 0.000315915680961711 NA NA NA hsa-miR-142-3p TBL1X -1.4243101967815 1.92609481097765e-14 -0.210527078758218 0.0538137802227018 MirTarget -0.102243557257819 0.000205263330309458 NA NA NA hsa-miR-181a-5p TBL1X 0.250113435902954 0.0551933249319293 -0.210527078758218 0.0538137802227018 MirTarget -0.195981076452364 1.31283993255368e-06 NA NA NA hsa-miR-181b-5p TBL1X 0.488256489401108 0.00105321129419701 -0.210527078758218 0.0538137802227018 MirTarget -0.174048839194183 7.72788457911812e-07 NA NA NA hsa-miR-181c-5p TBL1X -0.00639394152050299 0.969127212255928 -0.210527078758218 0.0538137802227018 MirTarget -0.176940535352193 2.67948938267401e-08 NA NA NA hsa-miR-181d-5p TBL1X 0.161600964883517 0.363806828762999 -0.210527078758218 0.0538137802227018 MirTarget -0.150698378969438 3.52959108534418e-07 NA NA NA hsa-miR-133a-3p TCF7 -0.628141411173506 0.0119847391134837 0.316885181039244 0.149291794426295 MirTarget -0.211821210882707 7.11167273763377e-07 NA NA NA hsa-miR-215-5p TCF7 -0.981544773246509 3.14452272477156e-05 0.316885181039244 0.149291794426295 MirTarget -0.173472143860975 0.000107082025354146 NA NA NA hsa-miR-331-3p TCF7 -0.283974346994635 0.0373785411053202 0.316885181039244 0.149291794426295 MirTarget -0.479855997763643 5.36153680989195e-10 NA NA NA hsa-miR-491-5p TCF7 -0.369122930844418 0.0154047757048929 0.316885181039244 0.149291794426295 MirTarget -0.176537669938362 0.012983394482481 NA NA NA hsa-miR-204-5p TCF7L1 -0.537962150012103 0.0330895493358849 -0.133055904354748 0.400767225696702 MirTarget -0.160817949371994 9.24763373186673e-08 NA NA NA hsa-miR-30b-3p TCF7L1 -0.439724365151373 0.000947180503583586 -0.133055904354748 0.400767225696702 MirTarget -0.128187741203912 0.027049850040723 NA NA NA hsa-miR-942-5p TCF7L2 0.346451845105263 0.0283255399972342 -0.337137194899186 7.09586898305443e-05 MirTarget -0.102128789748066 9.53611863162584e-05 NA NA NA hsa-miR-378a-5p VANGL2 -1.58667444700188 3.19640857320504e-17 -0.695002958600546 0.0292238308957975 MirTarget -0.376638409057428 1.76672899983547e-06 NA NA NA hsa-miR-378a-3p WNT10A -1.1920055906972 3.23538871733634e-10 -0.699775326592301 0.014837769527789 MirTarget -0.311876203963016 1.46588032688135e-05 NA NA NA hsa-miR-378c WNT10A -1.54028191929038 2.70131554214866e-15 -0.699775326592301 0.014837769527789 MirTarget -0.223225797245087 0.00130113406406967 NA NA NA hsa-miR-548b-3p WNT2 -0.0203576084717134 0.930819503166956 -3.91913726472358 3.44531322240171e-22 MirTarget -0.502061495825289 1.54565101391317e-08 NA NA NA hsa-miR-146a-5p WNT3 -0.742958238440575 0.000765983177482633 -0.0427691985857284 0.782956133291661 MirTarget -0.113145320629351 0.000853907137316349 NA NA NA hsa-miR-324-3p WNT3 0.260348469146494 0.0506141704203545 -0.0427691985857284 0.782956133291661 MirTarget -0.152449309964257 0.0073953316853805 NA NA NA hsa-miR-671-5p WNT3 0.843645373345787 3.92794196273313e-08 -0.0427691985857284 0.782956133291661 MirTarget -0.122495664510585 0.0117037669843825 NA NA NA hsa-miR-195-5p WNT3A -1.85907534356434 1.47434041676402e-22 1.98708616870099 1.63071643507271e-06 MirTarget -0.344445023915739 0.000703711150128669 25174704;26573286 MicroRNA 195 acts as a tumor suppressor by directly targeting Wnt3a in HepG2 hepatocellular carcinoma cells; Luciferase reporter assay was used to determine whether Wnt3a was a target of miR-195; Furthermore Wnt3a was demonstrated to be directly targeted by miR-195; These findings suggest that miR-195 is key in regulating cell proliferation cell cycle and apoptosis through targeting Wnt3a;Eribulin upregulates miR 195 expression and downregulates Wnt3a expression in non basal like type of triple negative breast cancer cell MDA MB 231; The expression level of miR-195 targeting Wnt3a significantly decreased compared to the control in MDA-MB-231 whereas it significantly increased in HCC1143; These results showed that exposure to eribulin highly increased the expression of miR-195 while it decreased the expression of Wnt3a in non-basal-like type of TNBC ; liver cancer;breast cancer hsa-miR-424-5p WNT3A -2.62653257498508 2.38997974737991e-50 1.98708616870099 1.63071643507271e-06 MirTarget -0.276402093402075 0.00707893809064417 NA NA NA hsa-miR-885-5p WNT5A -0.940994379567566 0.00118729865914986 -0.379867591757487 0.265970692489084 MirTarget -0.12433712248163 0.0293178719088217 NA NA NA hsa-miR-664a-5p WNT7B -0.0738022124558593 0.597681758599428 -2.49986156980565 3.55477150766295e-09 MirTarget -0.350084715832488 0.0208450119464205 NA NA NA