miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-140-3p ADAM17 -0.296251775392129 0.127539826012144 0.994636317946211 5.51755480031279e-05 PITA;miRNATAP -0.474071286081446 2.36311281452448e-07 NA NA NA hsa-miR-326 ADAM17 -0.429748586406214 0.2629894124021 0.994636317946211 5.51755480031279e-05 miRanda -0.264959360735862 5.77352326867345e-09 26111641 Adam17 a Target of Mir 326 Promotes Emt Induced Cells Invasion in Lung Adenocarcinoma; RT-PCR and Western blot were used to detect the expression of miR-326 and ADAM17 in lung adenocarcinoma samples n=73; Furthermore we confirmed that ADAM17 is a target of miR-326 which is involved in EMT and cells invasion; These findings revealed that ADAM17 a target of miR-326 promoted EMT-induced cells invasion in lung adenocarcinoma lung cancer hsa-miR-338-3p ADAM17 -0.959276231066179 0.0191473351014091 0.994636317946211 5.51755480031279e-05 PITA;miRanda;miRNATAP -0.314396844129743 9.40724650370748e-15 26617808 MiR 338 3p inhibits the proliferation and migration of gastric cancer cells by targeting ADAM17; Moreover we identified A disintegrin and metalloproteinase 17 ADAM17 gene as potential target of miR-338-3p; Importantly ADAM17 rescued the miR-338-3p mediated inhibition of cell proliferation migration and invasion; Our study suggested that miR-338-3p is significantly decreased in gastric cancer and inhibits cell proliferation migration and invasion partially via the downregulation of ADAM17 gastric cancer hsa-miR-7-1-3p ADAM17 0.709309110750947 0.0412301737463194 0.994636317946211 5.51755480031279e-05 mirMAP -0.231395650969544 4.48370261624986e-06 NA NA NA hsa-miR-186-5p CREBBP 0.149964130725901 0.434709542998771 -0.106993896504943 0.454357945668245 mirMAP;miRNATAP -0.143307553733926 0.0076774519745605 NA NA NA hsa-miR-342-3p CTBP2 0.318119432680668 0.269150960124243 -0.0134780178559462 0.944383343192984 MirTarget;PITA;miRanda;miRNATAP -0.286074448448953 4.5793712333209e-10 NA NA NA hsa-miR-107 DLL1 0.904627575346218 4.67936495073904e-05 0.230376179389923 0.511663538550597 PITA;miRanda;miRNATAP -0.298415670534343 0.00773739506044995 NA NA NA hsa-miR-326 DLL1 -0.429748586406214 0.2629894124021 0.230376179389923 0.511663538550597 miRanda -0.208040028600831 0.00151073451723997 NA NA NA hsa-miR-338-5p DLL1 -1.19659203838734 0.0100316010080496 0.230376179389923 0.511663538550597 PITA;miRNATAP -0.223831920222127 2.03328833821961e-05 NA NA NA hsa-miR-429 DLL1 1.40182602301928 0.00900426780286475 0.230376179389923 0.511663538550597 miRanda;miRNATAP -0.121037268575795 0.00861346132719073 NA NA NA hsa-let-7a-3p DLL4 0.503048155002889 0.0411145454335299 0.322876977377861 0.35188143335138 miRNATAP -0.331111517051426 0.000998620117334551 NA NA NA hsa-let-7b-3p DLL4 0.21838629112113 0.296038413622566 0.322876977377861 0.35188143335138 miRNATAP -0.328364098554486 0.0064422017166331 NA NA NA hsa-miR-125b-5p DLL4 -0.509303501421334 0.133265526313161 0.322876977377861 0.35188143335138 miRNATAP -0.293905342036624 4.47966039428613e-05 NA NA NA hsa-miR-199a-3p DLL4 0.85352674491639 0.000360518331912285 0.322876977377861 0.35188143335138 PITA -0.307556426155541 0.00277202856189735 NA NA NA hsa-miR-199b-3p DLL4 0.860968252593043 0.00032297319521262 0.322876977377861 0.35188143335138 PITA -0.307507304158154 0.00274993416252429 NA NA NA hsa-miR-27a-3p DLL4 1.29886998470345 2.68986118553486e-08 0.322876977377861 0.35188143335138 miRNATAP -0.501208635168389 6.76686684661312e-07 NA NA NA hsa-miR-27b-3p DLL4 0.0836323965901755 0.725273923274 0.322876977377861 0.35188143335138 miRNATAP -0.568984609779458 2.56413616749496e-08 NA NA NA hsa-miR-944 DLL4 3.33123095809751 0.0177835044930391 0.322876977377861 0.35188143335138 PITA;miRNATAP -0.14872032498947 1.61783715798129e-14 NA NA NA hsa-miR-1254 DTX1 0.941374574140312 0.0605480748500796 -0.0314127430623294 0.933721520740869 miRNATAP -0.300502287619991 1.87909816719914e-06 NA NA NA hsa-miR-324-5p DTX1 1.08820215809537 3.11674414561836e-05 -0.0314127430623294 0.933721520740869 PITA;miRanda -0.44835731760495 7.42058341232058e-06 NA NA NA hsa-miR-331-3p DTX1 1.04880525429426 9.99995355989124e-05 -0.0314127430623294 0.933721520740869 PITA;miRNATAP -0.408744229574188 2.74253034086494e-05 NA NA NA hsa-miR-421 DTX1 1.80720854070385 1.59709651202848e-07 -0.0314127430623294 0.933721520740869 PITA;miRanda;miRNATAP -0.249056484197303 0.000924446153583591 NA NA NA hsa-miR-429 DTX1 1.40182602301928 0.00900426780286475 -0.0314127430623294 0.933721520740869 miRNATAP -0.183243635905887 0.000190973932126439 NA NA NA hsa-miR-484 DTX1 0.71327898984355 0.00233605130771196 -0.0314127430623294 0.933721520740869 miRNATAP -0.367706020654848 0.00133919143035216 NA NA NA hsa-let-7e-5p DTX2 0.405855894534493 0.196257828016759 1.01453404619536 4.80785260397202e-05 miRNATAP -0.164340606110757 0.00443701750726223 NA NA NA hsa-miR-107 DTX3 0.904627575346218 4.67936495073904e-05 -0.398009490122832 0.34208921348715 miRanda -0.426254945540802 0.00139156807016121 NA NA NA hsa-miR-148a-5p DTX3 -0.69329616490858 0.0793012233740369 -0.398009490122832 0.34208921348715 mirMAP -0.242992556727029 0.00120677524315012 NA NA NA hsa-miR-3614-5p DTX3 1.10426689932954 0.00706308396674599 -0.398009490122832 0.34208921348715 MirTarget -0.382646216089867 7.72754630108528e-08 NA NA NA hsa-let-7b-5p DTX4 0.0582902155815681 0.781400138984745 0.439841725489873 0.325238965809273 miRNATAP -0.67341844969294 1.01192119866447e-05 NA NA NA hsa-miR-125b-5p DTX4 -0.509303501421334 0.133265526313161 0.439841725489873 0.325238965809273 mirMAP;miRNATAP -0.381523341812503 4.02367628332829e-05 NA NA NA hsa-miR-136-5p DTX4 -0.392356229753493 0.199261817142042 0.439841725489873 0.325238965809273 mirMAP -0.302597279301932 0.00381255143943006 NA NA NA hsa-miR-27a-3p DTX4 1.29886998470345 2.68986118553486e-08 0.439841725489873 0.325238965809273 miRNATAP -0.768935218833805 2.10103276558374e-09 NA NA NA hsa-miR-27b-3p DTX4 0.0836323965901755 0.725273923274 0.439841725489873 0.325238965809273 miRNATAP -0.755673571853007 9.17987603430291e-09 NA NA NA hsa-miR-365a-3p DTX4 -0.891537000455889 0.0025537650440002 0.439841725489873 0.325238965809273 mirMAP -0.726623686359032 8.4683029030877e-13 NA NA NA hsa-miR-150-5p DVL3 0.147461377429675 0.753719621305461 0.509159557836826 0.0191555023576877 MirTarget -0.136288717042111 2.80149026328444e-05 NA NA NA hsa-miR-29b-2-5p DVL3 -1.7015307882027 2.84239251703401e-10 0.509159557836826 0.0191555023576877 MirTarget -0.259672303335612 1.5757856884015e-06 NA NA NA hsa-miR-30d-3p DVL3 -0.545113326540761 0.0433733076874155 0.509159557836826 0.0191555023576877 MirTarget -0.208357364803817 0.00027782270884786 NA NA NA hsa-miR-338-3p DVL3 -0.959276231066179 0.0191473351014091 0.509159557836826 0.0191555023576877 miRanda -0.227023794827862 3.31810274034888e-10 NA NA NA hsa-miR-362-5p DVL3 -0.354508685915981 0.354912078595613 0.509159557836826 0.0191555023576877 PITA;TargetScan;miRNATAP -0.206660325578012 1.64767658075141e-07 NA NA NA hsa-miR-106b-5p EP300 1.70863907461894 2.04074794107142e-08 0.0301764271351921 0.833038220279424 miRNATAP -0.100179986132884 0.00163708231399858 NA NA NA hsa-miR-212-3p EP300 0.960352937108106 0.00133449812322732 0.0301764271351921 0.833038220279424 MirTarget;miRNATAP -0.119462144893836 0.000325617297555144 NA NA NA hsa-miR-26a-5p EP300 -0.384110714440647 0.0442498636014044 0.0301764271351921 0.833038220279424 miRNATAP -0.189916321506519 0.000381014097443189 NA NA NA hsa-miR-26b-5p EP300 -0.301646326928219 0.160081421968103 0.0301764271351921 0.833038220279424 miRNAWalker2_validate;miRNATAP -0.141211197444202 0.00298659835807985 NA NA NA hsa-miR-342-3p HDAC1 0.318119432680668 0.269150960124243 0.784065504987803 4.05383814767719e-06 miRanda -0.134814787267207 0.00172083743938278 NA NA NA hsa-miR-145-5p HDAC2 -1.75133578902314 1.54965572197748e-05 0.542710762381445 0.000828127815013922 miRNAWalker2_validate -0.124030510119461 6.69047341696702e-06 23499894 MiR 145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer; Ectopic expression of miRNA mimics evidenced that miR-145 suppresses HDAC2 expression in HCC cells; In conclusion we suggest that loss or suppression of miR-145 may cause aberrant overexpression of HDAC2 and promote HCC tumorigenesis tumorigenesis liver cancer hsa-miR-195-3p HDAC2 -1.34779269408059 2.01619826639376e-05 0.542710762381445 0.000828127815013922 mirMAP -0.140645211882781 8.93603828833916e-05 NA NA NA hsa-miR-30a-3p HDAC2 -1.73205137750899 3.2425754511091e-07 0.542710762381445 0.000828127815013922 mirMAP -0.105686746205829 0.00142603990586771 NA NA NA hsa-miR-30a-5p HDAC2 -1.71922855140016 3.20574349285256e-07 0.542710762381445 0.000828127815013922 mirMAP -0.113207139255158 0.000686202544426317 NA NA NA hsa-miR-129-5p JAG1 -2.56914016541176 2.36237896095709e-06 0.962310028491761 0.00973760976156012 PITA;miRanda;miRNATAP -0.151749512391114 0.00168899147095467 NA NA NA hsa-miR-140-3p JAG1 -0.296251775392129 0.127539826012144 0.962310028491761 0.00973760976156012 MirTarget;PITA;miRNATAP -0.501626710311565 0.000325183915876784 NA NA NA hsa-miR-186-5p JAG1 0.149964130725901 0.434709542998771 0.962310028491761 0.00973760976156012 MirTarget;miRNATAP -0.623503000272576 9.15667941341448e-06 NA NA NA hsa-miR-200a-3p JAG1 0.717826667295984 0.193912116506827 0.962310028491761 0.00973760976156012 miRNATAP -0.136582788973851 0.00450333251455495 NA NA NA hsa-miR-217 JAG1 -0.0121404731225336 0.980818372851502 0.962310028491761 0.00973760976156012 PITA;miRanda -0.155029091217586 0.00328215447800499 NA NA NA hsa-miR-26a-5p JAG1 -0.384110714440647 0.0442498636014044 0.962310028491761 0.00973760976156012 MirTarget;miRNATAP -0.533202242361823 0.000168156479670271 NA NA NA hsa-miR-26b-3p JAG1 -0.0103961389461977 0.965770899625511 0.962310028491761 0.00973760976156012 miRNATAP -0.295499047454268 0.00827027284698702 NA NA NA hsa-miR-26b-5p JAG1 -0.301646326928219 0.160081421968103 0.962310028491761 0.00973760976156012 MirTarget;miRNATAP -0.345162401544003 0.00638590691728833 NA NA NA hsa-miR-335-3p JAG1 2.5197689063267 2.20084506976733e-09 0.962310028491761 0.00973760976156012 MirTarget -0.162937474957614 0.00722552434472484 NA NA NA hsa-miR-335-5p JAG1 1.59953351087307 5.56170899867314e-05 0.962310028491761 0.00973760976156012 miRNATAP -0.271009683800408 3.21377383107555e-05 NA NA NA hsa-miR-361-3p JAG1 -0.126462931388735 0.566052688733137 0.962310028491761 0.00973760976156012 miRNATAP -0.385001202681167 0.00175501289792813 NA NA NA hsa-miR-375 JAG1 -2.94506033785642 0.00570147601654791 0.962310028491761 0.00973760976156012 miRNAWalker2_validate -0.162387554689125 4.534477190387e-12 NA NA NA hsa-miR-429 JAG1 1.40182602301928 0.00900426780286475 0.962310028491761 0.00973760976156012 miRanda -0.130405592754328 0.00811332026248308 NA NA NA hsa-miR-628-5p JAG1 -0.535322919688788 0.0377881249470294 0.962310028491761 0.00973760976156012 MirTarget;PITA;miRNATAP -0.412385336478693 6.3759194348607e-05 NA NA NA hsa-miR-98-5p JAG1 0.919961309193122 2.61963790596372e-05 0.962310028491761 0.00973760976156012 miRNAWalker2_validate -0.352611045810388 0.00366965577833089 NA NA NA hsa-miR-140-3p JAG2 -0.296251775392129 0.127539826012144 1.12641936213457 0.00218867041563891 miRNATAP -0.798872467502902 2.80945944254287e-09 NA NA NA hsa-miR-140-5p JAG2 0.208193069681326 0.303002433893804 1.12641936213457 0.00218867041563891 miRanda -0.51970170715379 8.79091895884399e-05 NA NA NA hsa-miR-30a-5p JAG2 -1.71922855140016 3.20574349285256e-07 1.12641936213457 0.00218867041563891 miRNATAP -0.292860296964253 0.000109543939971424 NA NA NA hsa-miR-30b-5p JAG2 -0.430720743745757 0.0593564057320791 1.12641936213457 0.00218867041563891 miRNATAP -0.393656971681219 0.000743363492910195 NA NA NA hsa-miR-30c-5p JAG2 -0.983130268805942 4.60419218706127e-05 1.12641936213457 0.00218867041563891 miRNATAP -0.381943517303868 0.000416527463136174 NA NA NA hsa-miR-30d-5p JAG2 -0.5492586056147 0.0140125082460125 1.12641936213457 0.00218867041563891 miRNATAP -0.511655536640657 1.41475585620462e-05 NA NA NA hsa-miR-335-5p JAG2 1.59953351087307 5.56170899867314e-05 1.12641936213457 0.00218867041563891 miRNAWalker2_validate -0.190606393187732 0.00353045001278766 NA NA NA hsa-miR-501-3p JAG2 0.731876211669996 0.0270421347018303 1.12641936213457 0.00218867041563891 TargetScan;miRNATAP -0.249216521769408 0.00174154575235653 NA NA NA hsa-miR-502-3p JAG2 -0.16442685491191 0.557471818466728 1.12641936213457 0.00218867041563891 miRNATAP -0.537887422482444 5.13554437453007e-09 NA NA NA hsa-miR-342-3p KAT2A 0.318119432680668 0.269150960124243 0.953808025188632 6.42219677496228e-08 MirTarget;miRanda -0.120571920546281 0.00770325267362627 NA NA NA hsa-miR-106b-5p KAT2B 1.70863907461894 2.04074794107142e-08 -1.91050199643306 2.45481459492977e-09 miRNAWalker2_validate;miRTarBase;MirTarget -0.404496076518756 3.6126061829124e-08 NA NA NA hsa-miR-17-5p KAT2B 1.65862087862483 8.45603406215941e-08 -1.91050199643306 2.45481459492977e-09 MirTarget;TargetScan -0.449016867759101 3.71905719057915e-10 23095762 miR 17 5p targets the p300/CBP associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells; Targeting of PCAF by miR-17-5p was evaluated using the luciferase reporter assay; Expression of PCAF in PCa cells was associated with the downregulation of miR-17-5p; Targeting of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells; PCAF is upregulated in cultured PCa cells and upregulation of PCAF is associated with the downregulation of miR-17-5p; Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells prostate cancer hsa-miR-181a-5p KAT2B 1.39227281909646 1.91689469974826e-09 -1.91050199643306 2.45481459492977e-09 miRNAWalker2_validate;miRTarBase;MirTarget -0.31724703529174 0.00139495105379872 NA NA NA hsa-miR-181b-5p KAT2B 1.64216500592669 1.89228845300725e-08 -1.91050199643306 2.45481459492977e-09 miRNAWalker2_validate;miRTarBase;MirTarget -0.302000808524627 0.000111681400111693 NA NA NA hsa-miR-181d-5p KAT2B 0.65192727601808 0.0143398117228333 -1.91050199643306 2.45481459492977e-09 MirTarget -0.249661400865533 0.00537818161485531 NA NA NA hsa-miR-19a-3p KAT2B 1.26669687448473 0.000105972838514412 -1.91050199643306 2.45481459492977e-09 miRNAWalker2_validate -0.270269472344135 0.000147795960161001 NA NA NA hsa-miR-19b-3p KAT2B 0.759818275708988 0.00652779573186786 -1.91050199643306 2.45481459492977e-09 miRNAWalker2_validate -0.276832932548132 0.00110901990121025 NA NA NA hsa-miR-20a-3p KAT2B 1.13957127410163 0.000451087640268489 -1.91050199643306 2.45481459492977e-09 MirTarget -0.417427125823598 2.46891172727232e-09 NA NA NA hsa-miR-20a-5p KAT2B 1.4503375861709 5.7813456424762e-07 -1.91050199643306 2.45481459492977e-09 MirTarget -0.430034157249089 3.25606489914246e-08 NA NA NA hsa-miR-25-3p KAT2B 1.00604871526544 0.000421838061147906 -1.91050199643306 2.45481459492977e-09 miRNAWalker2_validate;miRTarBase;MirTarget -0.301580356648323 0.000244339805537654 NA NA NA hsa-miR-361-5p KAT2B 0.407725414130987 0.0181260969156347 -1.91050199643306 2.45481459492977e-09 miRanda -0.408693404029793 0.00392741232177735 NA NA NA hsa-miR-590-3p KAT2B 1.11654983899947 0.000160782154924864 -1.91050199643306 2.45481459492977e-09 MirTarget;miRanda;mirMAP;miRNATAP -0.219016369036298 0.00594750382086531 NA NA NA hsa-miR-590-5p KAT2B 1.04171442093217 0.000272475544954865 -1.91050199643306 2.45481459492977e-09 miRanda -0.327510896202918 5.97967209634549e-05 NA NA NA hsa-miR-92a-3p KAT2B 1.2209325870225 6.8757197708107e-06 -1.91050199643306 2.45481459492977e-09 miRNAWalker2_validate;MirTarget -0.524009187770339 2.51983497129803e-10 NA NA NA hsa-miR-92b-3p KAT2B 1.33518446513417 1.45350885391576e-06 -1.91050199643306 2.45481459492977e-09 MirTarget -0.489723873760317 1.58722745994572e-09 NA NA NA hsa-miR-93-5p KAT2B 1.7515174434778 1.59386482413883e-08 -1.91050199643306 2.45481459492977e-09 miRNAWalker2_validate;miRTarBase;MirTarget -0.390460872011249 6.37625659837604e-08 NA NA NA hsa-miR-125a-5p LFNG -0.878090699011564 0.000213630844319685 -0.134393982137839 0.765867077754792 MirTarget;PITA;miRanda;miRNATAP -0.365952248548296 0.00675285358634353 NA NA NA hsa-miR-125b-5p LFNG -0.509303501421334 0.133265526313161 -0.134393982137839 0.765867077754792 MirTarget;miRNATAP -0.559651975895565 8.62006494641251e-10 NA NA NA hsa-miR-214-3p LFNG 1.01201534142544 0.00625092909225755 -0.134393982137839 0.765867077754792 MirTarget -0.225842596746099 0.00883792637335723 NA NA NA hsa-miR-365a-3p LFNG -0.891537000455889 0.0025537650440002 -0.134393982137839 0.765867077754792 mirMAP -0.535544630000288 4.10723201179543e-07 NA NA NA hsa-miR-30b-5p MAML1 -0.430720743745757 0.0593564057320791 0.095572413807405 0.489574581409329 MirTarget -0.126457299248353 0.0032441064994919 NA NA NA hsa-miR-576-5p MAML2 0.625714137488957 0.0417100301848969 0.00929392671318841 0.974330683053453 mirMAP -0.195209865689701 0.00344730793616804 NA NA NA hsa-miR-205-5p MFNG 3.13520672931882 0.0293226471971167 -0.442070531973297 0.226307917249934 MirTarget -0.107609130590007 4.21893256924523e-10 NA NA NA hsa-miR-219a-5p MFNG 0.605535434887599 0.0854495887591817 -0.442070531973297 0.226307917249934 MirTarget -0.323736695851734 9.13166048827753e-06 NA NA NA hsa-miR-2355-5p MFNG 0.594869787574182 0.120591076715177 -0.442070531973297 0.226307917249934 MirTarget -0.224848932779954 0.0008715947803336 NA NA NA hsa-miR-101-3p NOTCH1 -0.451263906815861 0.0283387250173031 1.03457165666178 0.000183884001409579 MirTarget -0.410465637505241 2.51749676202837e-05 NA NA NA hsa-miR-139-5p NOTCH1 -1.83374360776637 1.22019901002824e-09 1.03457165666178 0.000183884001409579 PITA;miRanda;miRNATAP -0.244586591874221 0.000104547125974859 27173050;25149074;26299922;27738333;24885920 miR 139 5p sensitizes colorectal cancer cells to 5 fluorouracil by targeting NOTCH 1;MiR 139 5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1; Mechanistic investigations revealed that miR-139-5p suppress CRC cell invasion and metastasis by targeting AMFR and NOTCH1;MiR 139 5p inhibits the biological function of breast cancer cells by targeting Notch1 and mediates chemosensitivity to docetaxel; MiR-139-5p expression in MCF-7 MCF-7/Doc cells and in selected breast cancer tissue samples was confirmed by real-time PCR; cell viability was analyzed by Cell Counting Kit-8 assay; apoptosis and cell cycle were analyzed by flow cytometry; control of metastasis and invasion of breast cancer cells was measured by transwell assay; expression of Notch1 was measured by western blot; a luciferase reporter vector was constructed to identify the miR-139-5p target gene; MiR-139-5p not only attenuated the development of breast cancer cells but also mediated drug-resistance by regulating the expression of the downstream target gene Notch1;MiR 139 5p reverses CD44+/CD133+ associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells; We also identified NOTCH1 an important protein for stem cell maintenance and function as a direct target of miR-139-5p both in vitro and in a knockout mouse model; Notch1 expression was upregulated in tumor samples and inversely correlated with expression of miR-139-5p; Silencing NOTCH1 exerted an effect similar to overexpression of miR-139-5p by inhibiting the CD44+ and CD133+ population and reversing the drug-resistant phenotype; In conclusion miR-139-5p downregulated NOTCH1 signaling to reverse CD44+/CD133+-associated MDR in colorectal cancer cells;microRNA 139 5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer ;metastasis;metastasis;drug resistance;drug resistance; colorectal cancer;colorectal cancer;breast cancer;colorectal cancer;colorectal cancer hsa-miR-30a-5p NOTCH1 -1.71922855140016 3.20574349285256e-07 1.03457165666178 0.000183884001409579 miRNAWalker2_validate;miRTarBase;miRNATAP -0.237487101914633 3.11096506547323e-05 NA NA NA hsa-miR-30b-5p NOTCH1 -0.430720743745757 0.0593564057320791 1.03457165666178 0.000183884001409579 miRNATAP -0.359873257715373 3.94249576060544e-05 NA NA NA hsa-miR-30c-5p NOTCH1 -0.983130268805942 4.60419218706127e-05 1.03457165666178 0.000183884001409579 miRNATAP -0.328013194317787 5.53414847804594e-05 23974200 We identified NOTCH1 as a direct target of miR-30c; Finally a block of miR-30c prevents C/EBPα-induced downregulation of Notch1 protein and leads to a reduced CD11b expression in myeloid differentiation; Our study presents the first evidence that C/EBPα miR-30c and Notch1 together play a critical role in granulocytic differentiation and AML and particularly in AML with CEBPA mutations differentiation acute myeloid leukemia hsa-miR-30d-5p NOTCH1 -0.5492586056147 0.0140125082460125 1.03457165666178 0.000183884001409579 miRNATAP -0.28107214113315 0.0018063783049975 NA NA NA hsa-miR-32-5p NOTCH1 0.415247682945382 0.106458022460373 1.03457165666178 0.000183884001409579 miRNATAP -0.250670532538739 0.00133267590955028 NA NA NA hsa-miR-326 NOTCH1 -0.429748586406214 0.2629894124021 1.03457165666178 0.000183884001409579 miRNAWalker2_validate;miRTarBase -0.166722970723998 0.00149451512551307 NA NA NA hsa-miR-103a-3p NOTCH2 0.840525139266028 5.83536475789158e-07 -0.258396659712914 0.287754032641363 MirTarget -0.37130303738704 0.000279620250229799 NA NA NA hsa-miR-106a-5p NOTCH2 -0.173255688252641 0.642872703263671 -0.258396659712914 0.287754032641363 miRNAWalker2_validate -0.134670778156744 0.00358480805526076 NA NA NA hsa-miR-107 NOTCH2 0.904627575346218 4.67936495073904e-05 -0.258396659712914 0.287754032641363 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.362745024515323 1.75816911688454e-06 NA NA NA hsa-miR-130b-5p NOTCH2 0.701350393759937 0.0510142718395002 -0.258396659712914 0.287754032641363 miRNAWalker2_validate;MirTarget -0.182461536764061 0.000122195576781823 NA NA NA hsa-miR-15a-5p NOTCH2 1.03783090449383 7.40334108980898e-07 -0.258396659712914 0.287754032641363 MirTarget -0.375602682643082 2.61047740143889e-06 NA NA NA hsa-miR-15b-5p NOTCH2 1.62046407540723 5.42152621571078e-09 -0.258396659712914 0.287754032641363 MirTarget -0.218321650065076 0.000248378857529312 NA NA NA hsa-miR-16-1-3p NOTCH2 1.43227522002564 3.70920454953168e-08 -0.258396659712914 0.287754032641363 mirMAP -0.189056212946732 0.00334687783906731 NA NA NA hsa-miR-16-5p NOTCH2 1.00515772948091 5.33912942007619e-06 -0.258396659712914 0.287754032641363 miRNAWalker2_validate;MirTarget -0.390125832404426 2.46868571108581e-07 NA NA NA hsa-miR-17-5p NOTCH2 1.65862087862483 8.45603406215941e-08 -0.258396659712914 0.287754032641363 miRNAWalker2_validate -0.240734585235498 6.00759166843726e-06 NA NA NA hsa-miR-183-5p NOTCH2 1.65900927871187 0.000522025364980187 -0.258396659712914 0.287754032641363 miRNAWalker2_validate -0.116073706664705 0.0010305717197732 NA NA NA hsa-miR-185-5p NOTCH2 1.14351510556643 1.07346945085714e-08 -0.258396659712914 0.287754032641363 MirTarget -0.277697934863656 0.000990946267662949 NA NA NA hsa-miR-186-5p NOTCH2 0.149964130725901 0.434709542998771 -0.258396659712914 0.287754032641363 mirMAP -0.315079207848107 0.000596614775520951 NA NA NA hsa-miR-18a-3p NOTCH2 2.35188582849667 1.39401350286321e-08 -0.258396659712914 0.287754032641363 MirTarget -0.16301571486915 3.90441573914245e-05 NA NA NA hsa-miR-200a-5p NOTCH2 1.50371809098978 0.00263602434344863 -0.258396659712914 0.287754032641363 mirMAP -0.132279563777275 8.8223850239445e-05 NA NA NA hsa-miR-200b-5p NOTCH2 0.969871521250413 0.0530500454130183 -0.258396659712914 0.287754032641363 mirMAP -0.16044033769968 5.50353470025474e-06 NA NA NA hsa-miR-25-3p NOTCH2 1.00604871526544 0.000421838061147906 -0.258396659712914 0.287754032641363 miRNAWalker2_validate -0.191609471166706 0.00136236952156121 NA NA NA hsa-miR-29b-3p NOTCH2 -0.230693226193598 0.367461626035234 -0.258396659712914 0.287754032641363 MirTarget -0.19020760295181 0.00526317431666269 NA NA NA hsa-miR-30b-5p NOTCH2 -0.430720743745757 0.0593564057320791 -0.258396659712914 0.287754032641363 mirMAP -0.243398888161778 0.00140836082647822 NA NA NA hsa-miR-34a-5p NOTCH2 0.794251341270032 0.00024017386701179 -0.258396659712914 0.287754032641363 miRNAWalker2_validate;miRNATAP -0.222834716084215 0.00530683291806908 NA NA NA hsa-miR-423-5p NOTCH2 0.832613878736338 0.000791321227103338 -0.258396659712914 0.287754032641363 MirTarget -0.246500683034312 0.000354168024158134 NA NA NA hsa-miR-424-5p NOTCH2 1.08509868581983 0.000420473853818268 -0.258396659712914 0.287754032641363 MirTarget -0.218043314320312 7.32759617574408e-05 NA NA NA hsa-miR-429 NOTCH2 1.40182602301928 0.00900426780286475 -0.258396659712914 0.287754032641363 miRNATAP -0.154239970569199 7.26863729806803e-07 NA NA NA hsa-miR-577 NOTCH2 0.911619788986754 0.2256062124148 -0.258396659712914 0.287754032641363 mirMAP -0.126589383005886 2.41147864594981e-08 NA NA NA hsa-miR-590-3p NOTCH2 1.11654983899947 0.000160782154924864 -0.258396659712914 0.287754032641363 miRanda -0.202031782346418 0.000426730313491696 NA NA NA hsa-miR-590-5p NOTCH2 1.04171442093217 0.000272475544954865 -0.258396659712914 0.287754032641363 miRanda -0.209783768432532 0.000414336706503807 NA NA NA hsa-miR-7-1-3p NOTCH2 0.709309110750947 0.0412301737463194 -0.258396659712914 0.287754032641363 MirTarget;mirMAP -0.211405839302402 1.52902329147166e-05 NA NA NA hsa-miR-92a-3p NOTCH2 1.2209325870225 6.8757197708107e-06 -0.258396659712914 0.287754032641363 miRNAWalker2_validate -0.285963635382967 3.25606725858084e-06 NA NA NA hsa-miR-940 NOTCH2 1.64406174271686 0.000690854900107004 -0.258396659712914 0.287754032641363 MirTarget -0.129438918335928 0.00176726076839653 NA NA NA hsa-miR-150-5p NOTCH3 0.147461377429675 0.753719621305461 1.31921922110157 0.00125124632224904 miRNAWalker2_validate;miRTarBase -0.161886939397632 0.00986098369788139 NA NA NA hsa-miR-200a-3p NOTCH3 0.717826667295984 0.193912116506827 1.31921922110157 0.00125124632224904 mirMAP -0.285292325430261 3.16303068101919e-08 NA NA NA hsa-miR-335-5p NOTCH3 1.59953351087307 5.56170899867314e-05 1.31921922110157 0.00125124632224904 miRNAWalker2_validate -0.266091715262528 0.000232697771191359 NA NA NA hsa-miR-491-5p NOTCH3 -0.693578126269305 0.0313646742330058 1.31921922110157 0.00125124632224904 MirTarget;miRanda -0.302318215140374 0.00116653208559151 NA NA NA hsa-miR-660-5p NOTCH3 -0.0206552819434673 0.938868734063643 1.31921922110157 0.00125124632224904 MirTarget -0.758736364638652 3.71455758268541e-13 NA NA NA hsa-miR-7-5p NOTCH3 1.63575693499363 0.0124424214624534 1.31921922110157 0.00125124632224904 MirTarget -0.287917023202439 1.24095354252043e-10 NA NA NA hsa-miR-324-5p NOTCH4 1.08820215809537 3.11674414561836e-05 -0.758844466732387 0.0204961728404252 miRanda -0.278502377223683 0.00163655271215027 NA NA NA hsa-miR-34c-5p NOTCH4 2.20632574870337 0.000379662996168678 -0.758844466732387 0.0204961728404252 miRNAWalker2_validate;miRTarBase;miRanda;miRNATAP -0.170376833998079 3.37650973541733e-06 22074923 Ectopic expression of miR-34c reduced the self-renewal of BT-ICs inhibited epithelial-mesenchymal transition and suppressed migration of the tumor cells via silencing target gene Notch4 breast cancer hsa-miR-103a-3p NUMB 0.840525139266028 5.83536475789158e-07 -0.0598415290277163 0.681006334325772 miRNAWalker2_validate -0.168359849578704 0.00577810028025596 NA NA NA hsa-miR-374b-5p NUMB -0.188120735251554 0.394800117237392 -0.0598415290277163 0.681006334325772 miRNATAP -0.152532177098748 0.0011469164952214 NA NA NA hsa-let-7g-5p NUMBL 0.325297685027927 0.241142963826631 0.198431487826629 0.453095130641474 miRNATAP -0.294539685618081 1.16351869370315e-05 NA NA NA hsa-miR-140-5p NUMBL 0.208193069681326 0.303002433893804 0.198431487826629 0.453095130641474 MirTarget;miRanda;miRNATAP -0.407243211946357 1.36189520277663e-05 NA NA NA hsa-miR-141-3p NUMBL 1.45548825076434 0.00115958850961764 0.198431487826629 0.453095130641474 TargetScan -0.12878020020692 0.0017905306588059 NA NA NA hsa-miR-142-3p NUMBL 1.32364054836498 0.0001537753622128 0.198431487826629 0.453095130641474 miRNATAP -0.193720649249975 0.000224922010391662 NA NA NA hsa-miR-194-3p NUMBL 0.259420201261466 0.821811295418686 0.198431487826629 0.453095130641474 MirTarget -0.128642572999485 1.74010632017151e-17 NA NA NA hsa-miR-338-3p NUMBL -0.959276231066179 0.0191473351014091 0.198431487826629 0.453095130641474 miRanda -0.265951671583416 1.41590838342826e-09 NA NA NA hsa-miR-34a-5p NUMBL 0.794251341270032 0.00024017386701179 0.198431487826629 0.453095130641474 MirTarget;miRNATAP -0.423196459439742 6.61613016956382e-07 NA NA NA hsa-miR-362-3p NUMBL -0.0349414695893027 0.913780708043777 0.198431487826629 0.453095130641474 miRanda;miRNATAP -0.322216612734031 1.45415269808328e-08 NA NA NA hsa-miR-1271-5p PSEN1 1.15538250415776 0.00207865862606828 0.187762921658773 0.189573446266423 mirMAP -0.109129916916065 4.15046468769551e-05 NA NA NA hsa-miR-197-3p PSEN1 0.888854270009261 0.000195183808214449 0.187762921658773 0.189573446266423 mirMAP -0.11300484469513 0.00727075400583386 NA NA NA hsa-miR-183-5p PSEN2 1.65900927871187 0.000522025364980187 -0.0309680532844987 0.901203719311873 MirTarget;miRNATAP -0.130649085498122 0.000300983070897681 NA NA NA hsa-miR-34c-5p PSEN2 2.20632574870337 0.000379662996168678 -0.0309680532844987 0.901203719311873 miRanda -0.160001462165708 4.21731209067306e-09 NA NA NA hsa-miR-151a-3p RBPJ 1.00322719901751 7.20903658270795e-06 -0.391590660016552 0.00734579053071903 miRNATAP -0.123274000838898 0.00733175896093517 NA NA NA hsa-miR-15b-5p RBPJ 1.62046407540723 5.42152621571078e-09 -0.391590660016552 0.00734579053071903 MirTarget -0.120655004149257 0.000768046676379928 NA NA NA hsa-miR-200c-3p RBPJ 1.28185685499076 0.00369777635539177 -0.391590660016552 0.00734579053071903 mirMAP -0.106878469693801 2.72559665286448e-06 NA NA NA hsa-miR-139-5p SNW1 -1.83374360776637 1.22019901002824e-09 0.423909751991965 0.00103468511060739 miRanda -0.112751997751268 9.6336557033664e-05 NA NA NA