miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-5p AIFM1 -0.439381775414001 3.1119785480023e-05 0.0294238522846229 0.689657376138298 TargetScan;miRNATAP -0.101815701393406 0.000762286455915643 NA NA NA hsa-let-7b-5p AIFM1 -0.2489842756826 0.0211384499461719 0.0294238522846229 0.689657376138298 miRNATAP -0.162461321655645 3.39349255638955e-08 NA NA NA hsa-let-7e-5p AIFM1 0.0857356192778891 0.512869729833211 0.0294238522846229 0.689657376138298 miRNATAP -0.0760283341708985 0.00189172777412303 NA NA NA hsa-miR-125b-5p AKT1 -0.993460109818276 5.07736727659894e-12 0.298173909239758 1.68969918058543e-05 miRNAWalker2_validate;miRTarBase -0.0764370568775872 0.000205293787789151 NA NA NA hsa-miR-26b-5p AKT1 -0.254478038884324 0.0285227763044636 0.298173909239758 1.68969918058543e-05 miRNAWalker2_validate -0.0963004890811401 0.000226330185638013 NA NA NA hsa-miR-183-5p AKT2 1.4313129319945 6.25230916431996e-14 -0.267014169040862 1.10806435090223e-05 mirMAP -0.053253692065677 7.93795643193321e-05 NA NA NA hsa-miR-18a-5p AKT2 1.65455873230328 3.76457892277775e-20 -0.267014169040862 1.10806435090223e-05 mirMAP -0.054026235895546 0.000131755637090481 NA NA NA hsa-miR-21-5p AKT2 1.62465922021121 3.44191300985109e-58 -0.267014169040862 1.10806435090223e-05 miRNAWalker2_validate -0.0727347825982046 0.0019554364961675 NA NA NA hsa-miR-324-5p AKT2 1.66709479707179 1.45961450445769e-23 -0.267014169040862 1.10806435090223e-05 miRanda -0.0610733704339665 5.53498669642193e-05 NA NA NA hsa-miR-339-5p AKT2 1.07771430326938 2.45772601859307e-09 -0.267014169040862 1.10806435090223e-05 mirMAP -0.0507914809300617 0.000425524472805016 NA NA NA hsa-miR-708-5p AKT2 1.54207894190626 2.2887257992285e-19 -0.267014169040862 1.10806435090223e-05 miRNAWalker2_validate;miRTarBase -0.071663640411228 1.29870170200421e-06 22552290 Together our findings suggest that reduced miR-708 expression leads to prostate cancer initiation progression and development by regulating the expression of CD44 as well as AKT2 miR-708 therefore may represent a novel therapeutic target or diagnostic and prognostic biomarker in prostate cancer progression prostate cancer hsa-miR-766-3p AKT2 1.07002176594541 8.2375790648059e-16 -0.267014169040862 1.10806435090223e-05 mirMAP -0.0521036283084985 0.00735346205877519 NA NA NA hsa-miR-139-5p AKT3 -1.46099200329485 7.85040381494472e-22 0.757395805826156 5.24354425444781e-05 PITA;miRanda -0.204988506808972 7.26517518198736e-05 NA NA NA hsa-miR-15a-5p AKT3 0.783550182002274 2.60699595655907e-11 0.757395805826156 5.24354425444781e-05 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265716982670402 0.000109391971495535 NA NA NA hsa-miR-17-3p AKT3 -0.0127974722290336 0.909559935689875 0.757395805826156 5.24354425444781e-05 miRNATAP -0.167975584406356 0.0224606563631626 NA NA NA hsa-miR-17-5p AKT3 1.41924888736771 2.75805544953758e-18 0.757395805826156 5.24354425444781e-05 TargetScan;miRNATAP -0.210478431167346 1.46778910374435e-05 NA NA NA hsa-miR-205-3p AKT3 1.2960640797621 5.80786479909147e-11 0.757395805826156 5.24354425444781e-05 mirMAP -0.248708307357298 5.71786142986847e-10 NA NA NA hsa-miR-20a-5p AKT3 1.1531986665452 1.02385132917958e-11 0.757395805826156 5.24354425444781e-05 miRNATAP -0.244010493055021 2.19437052623105e-07 NA NA NA hsa-miR-29b-3p AKT3 -0.110721443686039 0.511264554091106 0.757395805826156 5.24354425444781e-05 miRNATAP -0.255169036216248 1.32894370465011e-07 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-362-3p AKT3 -0.697212068252854 2.61718493418184e-06 0.757395805826156 5.24354425444781e-05 miRanda -0.198442787422331 0.000314248564221821 NA NA NA hsa-miR-362-5p AKT3 0.41089772861323 0.0404254902071382 0.757395805826156 5.24354425444781e-05 PITA;TargetScan;miRNATAP -0.156881795440952 0.000120211641903581 NA NA NA hsa-miR-501-3p AKT3 0.820141346319976 1.74562930463389e-08 0.757395805826156 5.24354425444781e-05 miRNATAP -0.116799718079644 0.0368818426368756 NA NA NA hsa-miR-139-5p APAF1 -1.46099200329485 7.85040381494472e-22 0.251747723736351 0.00842695067076781 mirMAP -0.0664632017115897 0.0115086169105477 NA NA NA hsa-miR-664a-3p APAF1 -0.256108763664991 0.0513188660751664 0.251747723736351 0.00842695067076781 mirMAP -0.133093485485973 2.59239090057129e-05 NA NA NA hsa-miR-18a-5p ATM 1.65455873230328 3.76457892277775e-20 -0.093354974252863 0.454138180986134 miRNAWalker2_validate;miRTarBase;MirTarget -0.172854853213816 1.55248713992951e-09 23437304;25963391;23857602;23229340 MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases ;;;progression colorectal cancer;cervical and endocervical cancer;breast cancer;colon cancer hsa-miR-19b-3p ATM 0.538732279378089 0.000622008277870679 -0.093354974252863 0.454138180986134 miRNAWalker2_validate -0.186784239327415 3.93187101386662e-08 NA NA NA hsa-miR-203a-3p ATM 0.0441399794719697 0.880456392176704 -0.093354974252863 0.454138180986134 MirTarget -0.104881351322909 9.03651632141775e-09 24145123;27542403 miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM;MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression drug resistance;metastasis colorectal cancer;gastric cancer hsa-miR-205-3p ATM 1.2960640797621 5.80786479909147e-11 -0.093354974252863 0.454138180986134 mirMAP -0.0900513662956023 0.000793417337761544 NA NA NA hsa-miR-21-5p ATM 1.62465922021121 3.44191300985109e-58 -0.093354974252863 0.454138180986134 mirMAP -0.140220573701406 0.00355116923594901 26289851 MiR-21 is an oncomiR that is overexpressed in nearly all cancers including ATC; Hence suppression of miR-21 could pave the way for ATC therapy thyroid cancer hsa-miR-30b-5p ATM -0.400238605368173 0.00346540992719245 -0.093354974252863 0.454138180986134 mirMAP -0.0986798441592363 0.0128618560350808 25202329 However specific miRNAs are downregulated in ATC such as those of the miR-200 and miR-30 families which are important negative regulators of cell migration invasion and epithelial-to-mesenchymal transition EMT processes that are overactivated in ATC cell migration thyroid cancer hsa-miR-30c-5p ATM 0.021222006155897 0.886366656528128 -0.093354974252863 0.454138180986134 mirMAP -0.12262645993067 0.000806314047643549 NA NA NA hsa-miR-324-5p ATM 1.66709479707179 1.45961450445769e-23 -0.093354974252863 0.454138180986134 miRanda -0.0971721293176944 0.00178094450969017 NA NA NA hsa-miR-339-5p ATM 1.07771430326938 2.45772601859307e-09 -0.093354974252863 0.454138180986134 miRanda -0.139243170775692 2.1104639922551e-06 NA NA NA hsa-miR-455-5p ATM 1.408595672323 5.52039116456697e-22 -0.093354974252863 0.454138180986134 miRanda -0.217802614613522 5.72421455047167e-10 NA NA NA hsa-miR-500a-5p ATM 0.675401699376111 8.24389004707854e-05 -0.093354974252863 0.454138180986134 mirMAP -0.142109646438286 5.47687546110341e-06 NA NA NA hsa-miR-576-5p ATM 0.940432050128373 6.90227595663302e-12 -0.093354974252863 0.454138180986134 mirMAP -0.165312006285652 1.91611455442744e-05 NA NA NA hsa-miR-590-5p ATM 0.763025362395968 3.65305892505623e-09 -0.093354974252863 0.454138180986134 mirMAP -0.147037048698993 0.000379931177124788 NA NA NA hsa-miR-92a-3p ATM 0.994679542307232 1.32587679156217e-16 -0.093354974252863 0.454138180986134 miRNAWalker2_validate -0.103772274344878 0.0183487891495439 NA NA NA hsa-miR-944 ATM 1.47323925060177 2.61626403984929e-13 -0.093354974252863 0.454138180986134 mirMAP -0.0919717195363556 0.000452258585991707 NA NA NA hsa-miR-127-3p BAD -1.47175957435172 9.8707469067377e-14 0.232698220027489 0.0410974615650229 miRanda;miRNATAP -0.109748766939369 6.41360405115286e-06 NA NA NA hsa-miR-326 BAD -0.425943992128769 0.0415010315530797 0.232698220027489 0.0410974615650229 miRanda -0.161061952496571 5.50625637973764e-12 NA NA NA hsa-miR-17-5p BCL2 1.41924888736771 2.75805544953758e-18 -0.910322309161486 1.41820798645135e-05 miRNAWalker2_validate;miRTarBase -0.286055141796067 1.32806406578446e-07 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-181b-5p BCL2 0.974255518824355 2.64876280203475e-16 -0.910322309161486 1.41820798645135e-05 miRNAWalker2_validate;miRTarBase -0.373058996674441 6.31834441315239e-07 25524579 Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression lung squamous cell cancer hsa-miR-205-3p BCL2 1.2960640797621 5.80786479909147e-11 -0.910322309161486 1.41820798645135e-05 mirMAP -0.227937256601493 4.79177139227398e-07 23612742 MicroRNA 205 a novel regulator of the anti apoptotic protein Bcl2 is downregulated in prostate cancer; In addition we describe the anti-apoptotic protein BCL2 as a target of miR-205 relevant for prostate cancer due to its role in prognosis of primary tumours and in the appearance of androgen independence; The repression of BCL2 by miR-205 was confirmed using reporter assays and western blotting; Consistent with its anti-apoptotic target BCL2 miR-205 promoted apoptosis in prostate cancer cells in response to DNA damage by cisplatin and doxorubicin in the prostate cancer cell lines PC3 and LnCap worse prognosis;drug resistance prostate cancer hsa-miR-20a-3p BCL2 1.34885093664027 2.07697464119202e-12 -0.910322309161486 1.41820798645135e-05 mirMAP -0.210143759838025 6.72382138476575e-06 NA NA NA hsa-miR-20a-5p BCL2 1.1531986665452 1.02385132917958e-11 -0.910322309161486 1.41820798645135e-05 miRNAWalker2_validate;miRTarBase -0.210135069736519 7.53662123683259e-05 NA NA NA hsa-miR-21-5p BCL2 1.62465922021121 3.44191300985109e-58 -0.910322309161486 1.41820798645135e-05 miRNAWalker2_validate;miRTarBase -0.44340837518524 4.13326577253647e-08 21468550;25994220;25381586;26555418;23359184;22964582;21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;lung cancer;pancreatic cancer hsa-miR-224-3p BCL2 0.502645536188015 0.0081142387260641 -0.910322309161486 1.41820798645135e-05 mirMAP -0.149838612967231 0.00210796622480369 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-224-5p BCL2 1.94534596857416 1.88348779207332e-19 -0.910322309161486 1.41820798645135e-05 mirMAP -0.353815516939307 5.70417527374627e-19 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-24-2-5p BCL2 1.27293931700635 4.48240091510596e-15 -0.910322309161486 1.41820798645135e-05 miRNAWalker2_validate;miRTarBase -0.493507075193325 1.92280534065188e-20 NA NA NA hsa-miR-29a-5p BCL2 0.323252792625584 0.0370417231222825 -0.910322309161486 1.41820798645135e-05 mirMAP -0.155079084813299 0.00916942782727535 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-365a-3p BCL2 0.446833934952926 0.00233857759218299 -0.910322309161486 1.41820798645135e-05 miRNAWalker2_validate;miRTarBase -0.618758400072067 4.65430504458955e-25 NA NA NA hsa-miR-450b-5p BCL2 1.25529820885833 1.18847120528666e-15 -0.910322309161486 1.41820798645135e-05 mirMAP -0.302976225522567 8.63706453164136e-08 NA NA NA hsa-miR-451a BCL2 -1.24311832053709 1.41247463891537e-06 -0.910322309161486 1.41820798645135e-05 miRNAWalker2_validate;miRTarBase -0.0936966276491703 0.00803911543880782 26516138;23053883 Western blot was used for the detection of the protein expression of Bcl-2 and Caspase 3 after the transfection of miR-451 mimics /inhibitors; Bioinformatics analysis demonstrated that Bcl-2 protein is a potential target gene for miR-451; Increased miR-451 expression may negatively regulate Bcl-2 mRNA and protein expression followed by affecting the protein expression of caspase 3 and accelerate the apoptosis in breast cancer indicating that miR-451 might influence the drug resistances of the Paclitaxel-resistant breast cancer cell line;The expression of miR-451 was analyzed by RT-PCR and the expressions of Bcl-2 AKT and phosphorylated AKT were analyzed by Western blotting; In comparison to the controls a significant increase in the expression of miR-451 was associated with significantly decreased expressions of Bcl-2 AKT and p-AKT and a significant increase in the apoptosis rate drug resistance; breast cancer;esophageal cancer hsa-miR-452-5p BCL2 0.373288744398455 0.0348485937209964 -0.910322309161486 1.41820798645135e-05 mirMAP -0.294458928135025 1.04088708041247e-08 NA NA NA hsa-miR-455-5p BCL2 1.408595672323 5.52039116456697e-22 -0.910322309161486 1.41820798645135e-05 mirMAP -0.672065921862735 3.74015168127993e-32 NA NA NA hsa-miR-542-3p BCL2 0.643308814904977 8.81635403230104e-07 -0.910322309161486 1.41820798645135e-05 mirMAP -0.295630720394228 2.17157389286201e-05 NA NA NA hsa-miR-590-5p BCL2 0.763025362395968 3.65305892505623e-09 -0.910322309161486 1.41820798645135e-05 miRanda -0.212747360248047 0.00250525422232118 NA NA NA hsa-miR-7-5p BCL2 1.55674721532755 2.41989824363914e-11 -0.910322309161486 1.41820798645135e-05 miRNAWalker2_validate;miRTarBase;mirMAP -0.241358237325723 1.79388200062243e-09 26464649;25862909;21750649 Western blotting was used to evaluate the effect of miR-7 on Bcl2 in A549 and H460 cells; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells;miR-7 overexpression correlated with diminished BCL2 expression but there was no relationship between miR-7 and EGFR expression neither in tumour samples nor in the cell lines; Of the two postulated miR-7 target genes we examined BCL2 but not EGFR seems to be a possible miR-7 target in OC;Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay; Moreover subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels; These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions ;; lung squamous cell cancer;ovarian cancer;lung squamous cell cancer hsa-miR-96-5p BCL2 1.42326703011157 4.39736150032373e-14 -0.910322309161486 1.41820798645135e-05 miRNAWalker2_validate;TargetScan -0.109700424292582 0.0214069877177276 NA NA NA hsa-let-7a-5p BCL2L1 -0.439381775414001 3.1119785480023e-05 -0.154367846037657 0.0815714192690394 TargetScan;miRNATAP -0.0935871111658212 0.0105117956197152 26915294;20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA poor survival; lung cancer;liver cancer hsa-let-7b-5p BCL2L1 -0.2489842756826 0.0211384499461719 -0.154367846037657 0.0815714192690394 miRNATAP -0.093561519221891 0.00918547846223866 26915294;20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA poor survival; lung cancer;liver cancer hsa-let-7i-5p BCL2L1 0.249440992451337 0.00426823922424972 -0.154367846037657 0.0815714192690394 miRNATAP -0.109687529663845 0.0140352259567586 NA NA NA hsa-miR-214-3p BCL2L1 -0.118240959890965 0.564962359782563 -0.154367846037657 0.0815714192690394 mirMAP -0.0640455074442814 0.000643253919843485 NA NA NA hsa-miR-342-5p BCL2L1 0.862385578881784 1.60007936373305e-08 -0.154367846037657 0.0815714192690394 miRNATAP -0.0782837859647974 0.00167982613091458 NA NA NA hsa-miR-491-5p BCL2L1 -0.541680329196715 0.00135829217561865 -0.154367846037657 0.0815714192690394 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda -0.0810869971574881 0.000639577760791084 25299770;20039318;23519249 We found that miR-491-5p efficiently induces apoptosis in IGROV1-R10 cells by directly inhibiting BCL-XL expression and by inducing BIM accumulation in its dephosphorylated form;Functional screening identifies a microRNA miR 491 that induces apoptosis by targeting Bcl XL in colorectal cancer cells; We demonstrated that Bcl-XL was a direct target of miR-491 and its silencing contributed to miR-491-induced apoptosis; Our study provides a new regulation of Bcl-XL by miR-491 in colorectal cancer cells and suggests a therapeutic potential of miRNAs for treating colorectal cancer by targeting Bcl-XL;Targeted site prediction indicated that both Bcl-XL and TP53 contain miR-491-5p recognizing sites in their 3' UTRs; Overexpression of miR-491-5p in the pancreatic cancer cell line SW1990 effectively inhibited both endogenous Bcl-XL and TP53 gene expressions ;; ovarian cancer;colorectal cancer;pancreatic cancer hsa-miR-625-5p BCL2L1 0.346770617079364 0.02860843739549 -0.154367846037657 0.0815714192690394 MirTarget -0.0926654631592816 0.000146717679437283 NA NA NA hsa-miR-338-5p BID -1.71946558699173 2.62649071488641e-23 0.969056554743071 1.68658061140478e-15 MirTarget -0.145216784372344 1.23781023880555e-06 NA NA NA hsa-miR-511-5p BID 0.214339847118675 0.232372953100021 0.969056554743071 1.68658061140478e-15 MirTarget -0.0664755059020883 0.0290812220073737 NA NA NA hsa-miR-29c-3p BIRC2 -2.08166260448948 8.3238369390898e-24 0.18069880611634 0.179325701779444 MirTarget -0.0997905921340128 0.000212084619636879 NA NA NA hsa-miR-624-5p BIRC2 -0.229389464626096 0.110488966509615 0.18069880611634 0.179325701779444 MirTarget -0.085186450430904 0.0380499399323087 NA NA NA hsa-miR-369-3p BIRC3 -1.2344419076994 2.66882944171146e-10 0.198923960920167 0.399501961994823 MirTarget;miRNATAP -0.254582128765042 7.46591748197274e-07 NA NA NA hsa-miR-34a-5p CAPN1 -0.117372471043915 0.364001947180738 -0.345177237196951 0.000552335520647139 miRNAWalker2_validate -0.177887816513636 1.20691946319079e-07 NA NA NA hsa-miR-491-5p CAPN1 -0.541680329196715 0.00135829217561865 -0.345177237196951 0.000552335520647139 miRanda -0.115803878290504 1.58075393409144e-05 NA NA NA hsa-miR-1468-5p CAPN2 -1.11814152104975 9.8203170781489e-10 -0.388105879595608 2.58697254508489e-05 MirTarget -0.0584656694637177 0.00725730847038062 NA NA NA hsa-miR-16-2-3p CAPN2 1.1567130855258 1.01867256952189e-14 -0.388105879595608 2.58697254508489e-05 mirMAP -0.104772126953605 6.57092403195766e-05 NA NA NA hsa-miR-20a-3p CAPN2 1.34885093664027 2.07697464119202e-12 -0.388105879595608 2.58697254508489e-05 MirTarget -0.0813055612687174 7.36583182538276e-05 NA NA NA hsa-miR-320a CAPN2 0.801356001806321 4.91397101474502e-09 -0.388105879595608 2.58697254508489e-05 miRanda -0.143202989189234 7.30028253235527e-07 NA NA NA hsa-miR-320b CAPN2 1.23473838180754 3.04337566045537e-14 -0.388105879595608 2.58697254508489e-05 miRanda -0.113234213195354 2.56568461933557e-06 NA NA NA hsa-miR-421 CAPN2 0.945488088619653 2.35762398527362e-09 -0.388105879595608 2.58697254508489e-05 miRanda -0.0532344335642941 0.03514303252764 NA NA NA hsa-miR-590-5p CAPN2 0.763025362395968 3.65305892505623e-09 -0.388105879595608 2.58697254508489e-05 miRanda -0.100279745841794 0.00114739582084897 NA NA NA hsa-miR-125a-5p CASP10 0.215366061934933 0.119550904549401 0.039121225798822 0.788947657309733 mirMAP -0.162387453843414 0.000416480376154383 NA NA NA hsa-miR-125b-5p CASP10 -0.993460109818276 5.07736727659894e-12 0.039121225798822 0.788947657309733 mirMAP -0.0865482498825985 0.0463545552624932 NA NA NA hsa-miR-129-5p CASP10 -0.246329588499478 0.436451191224681 0.039121225798822 0.788947657309733 mirMAP -0.0819187115885633 5.44870236841167e-05 NA NA NA hsa-miR-145-3p CASP10 -1.31204896009636 1.82103591686456e-24 0.039121225798822 0.788947657309733 mirMAP -0.192166130820007 4.59914252230619e-05 NA NA NA hsa-miR-145-5p CASP10 -0.46917511594055 0.000685297625493134 0.039121225798822 0.788947657309733 mirMAP -0.212338082257249 3.32413954629936e-06 NA NA NA hsa-miR-19b-3p CASP10 0.538732279378089 0.000622008277870679 0.039121225798822 0.788947657309733 MirTarget;mirMAP -0.0879965206443956 0.029150524333443 NA NA NA hsa-miR-217 CASP10 -1.35391381055929 2.42394951427902e-09 0.039121225798822 0.788947657309733 mirMAP -0.0620589558534999 0.0245197040572518 NA NA NA hsa-miR-28-3p CASP10 0.459875450032895 3.47095927872566e-07 0.039121225798822 0.788947657309733 mirMAP -0.233260925043599 0.000926341519158387 NA NA NA hsa-miR-320a CASP10 0.801356001806321 4.91397101474502e-09 0.039121225798822 0.788947657309733 miRanda -0.12628442292094 0.00591672003329478 NA NA NA hsa-miR-320b CASP10 1.23473838180754 3.04337566045537e-14 0.039121225798822 0.788947657309733 miRanda -0.0909206572098774 0.0173145854457611 NA NA NA hsa-miR-339-5p CASP10 1.07771430326938 2.45772601859307e-09 0.039121225798822 0.788947657309733 MirTarget -0.102649406189149 0.00304483060962374 NA NA NA hsa-miR-361-5p CASP10 0.0803683277369505 0.314043140368058 0.039121225798822 0.788947657309733 miRanda -0.230204401129846 0.00451838268683787 NA NA NA hsa-miR-589-3p CASP10 1.59559692667315 6.2886410639161e-15 0.039121225798822 0.788947657309733 mirMAP -0.0646326446521353 0.0404968834904397 NA NA NA hsa-miR-744-3p CASP10 1.18973028739247 4.23716909078104e-10 0.039121225798822 0.788947657309733 mirMAP -0.146249076641514 7.32196512259096e-06 NA NA NA hsa-let-7e-5p CASP3 0.0857356192778891 0.512869729833211 0.156697957856667 0.0654751351850113 MirTarget;miRNATAP -0.0615435117416801 0.0302503471341796 NA NA NA hsa-miR-193b-5p CASP3 1.10486595354104 6.41489920661805e-11 0.156697957856667 0.0654751351850113 MirTarget -0.0959327093970114 6.98085007905391e-06 NA NA NA hsa-miR-382-5p CASP3 -0.512675955239656 0.00311534081639733 0.156697957856667 0.0654751351850113 MirTarget -0.0683260335112868 0.00131534198180414 NA NA NA hsa-miR-106b-5p CASP7 0.50378717276868 1.45412404526866e-05 0.363834496392235 0.000409222376232367 miRNAWalker2_validate -0.0990435113738473 0.0104460246363754 22986525 MicroRNA 106b 25 cluster expression is associated with early disease recurrence and targets caspase 7 and focal adhesion in human prostate cancer; Moreover increased tumor miR-106b expression was associated with disease recurrence and the combination of high miR-106b and low CASP7 caspase-7 expressions in primary tumors was an independent predictor of early disease recurrence adjusted hazard ratio=4.1; 95% confidence interval: 1.6-12.3; The approach revealed that CASP7 is a direct target of miR-106b which was confirmed by western blot analysis and a 3'-untranslated region reporter assay; Moreover selected phenotypes induced by miR-106b knockdown in DU145 human prostate cancer cells did not develop when both miR-106b and CASP7 expression were inhibited recurrence prostate cancer hsa-miR-23b-3p CASP7 -0.497563803223134 3.31483353357535e-05 0.363834496392235 0.000409222376232367 MirTarget -0.0928933914512807 0.0132596816551458 NA NA NA hsa-miR-26b-5p CASP7 -0.254478038884324 0.0285227763044636 0.363834496392235 0.000409222376232367 miRNAWalker2_validate -0.0792649193527029 0.0420315706608015 NA NA NA hsa-miR-3065-3p CASP7 -0.543069092777161 0.0213164885178151 0.363834496392235 0.000409222376232367 MirTarget -0.0544075790698641 0.00423901801930349 NA NA NA hsa-miR-335-5p CASP7 -1.17227779671552 1.49282618530733e-10 0.363834496392235 0.000409222376232367 MirTarget -0.0935478617409457 0.000101578539642486 NA NA NA hsa-miR-361-5p CASP7 0.0803683277369505 0.314043140368058 0.363834496392235 0.000409222376232367 PITA;miRanda -0.333635392405375 3.86606160412075e-09 NA NA NA hsa-miR-664a-3p CASP7 -0.256108763664991 0.0513188660751664 0.363834496392235 0.000409222376232367 MirTarget -0.143855761567966 2.58475197893635e-05 NA NA NA hsa-miR-143-3p CASP8 -1.33760181792708 4.15335119989612e-12 0.61046806666974 2.40514026283481e-09 MirTarget -0.0508003336527814 0.0269087350610325 NA NA NA hsa-miR-217 CASP8 -1.35391381055929 2.42394951427902e-09 0.61046806666974 2.40514026283481e-09 miRanda -0.077744704284692 6.7860453550611e-05 NA NA NA hsa-miR-17-5p CASP9 1.41924888736771 2.75805544953758e-18 -0.463384781945098 2.35696508685012e-06 TargetScan -0.0670062365500947 0.00892524186871435 NA NA NA hsa-miR-193b-3p CASP9 1.72788400801602 3.0722151264559e-21 -0.463384781945098 2.35696508685012e-06 miRNAWalker2_validate -0.154521744765018 3.59150879724078e-12 NA NA NA hsa-miR-424-5p CASP9 1.48125289532143 9.10372985713165e-19 -0.463384781945098 2.35696508685012e-06 mirMAP -0.139144406558183 1.49418335447692e-08 NA NA NA hsa-miR-450b-5p CASP9 1.25529820885833 1.18847120528666e-15 -0.463384781945098 2.35696508685012e-06 mirMAP -0.0995166076399454 0.000189708540816875 NA NA NA hsa-miR-7-5p CASP9 1.55674721532755 2.41989824363914e-11 -0.463384781945098 2.35696508685012e-06 miRNAWalker2_validate -0.103910716853992 3.37252845720189e-08 NA NA NA hsa-miR-103a-2-5p CFLAR 1.37988337975616 6.74852943995612e-08 -0.347426428894746 0.000431581051522446 mirMAP -0.056878312605637 0.0016983751328847 NA NA NA hsa-miR-125a-5p CFLAR 0.215366061934933 0.119550904549401 -0.347426428894746 0.000431581051522446 miRanda -0.0771955415293337 0.0136516291366354 NA NA NA hsa-miR-130a-3p CFLAR 0.67051191119964 4.89747518735144e-06 -0.347426428894746 0.000431581051522446 mirMAP -0.126797344846313 1.27030194896023e-05 NA NA NA hsa-miR-130b-3p CFLAR 1.44628430084411 9.13980959861273e-24 -0.347426428894746 0.000431581051522446 mirMAP -0.180436885173479 1.66497251016581e-10 NA NA NA hsa-miR-15b-5p CFLAR 0.85315666454713 3.79816274836297e-12 -0.347426428894746 0.000431581051522446 mirMAP -0.098282293148221 0.0044054876459852 NA NA NA hsa-miR-199a-5p CFLAR -0.364835768178638 0.0435119211101981 -0.347426428894746 0.000431581051522446 mirMAP -0.0861663540872812 0.000293387043235243 NA NA NA hsa-miR-199b-5p CFLAR -1.08432682485992 7.68241801134089e-10 -0.347426428894746 0.000431581051522446 mirMAP -0.0526823339444795 0.0288774628828337 NA NA NA hsa-miR-301a-3p CFLAR 2.14132004241926 4.46255413526808e-25 -0.347426428894746 0.000431581051522446 mirMAP -0.0726559502126669 0.000238500610146496 NA NA NA hsa-miR-320a CFLAR 0.801356001806321 4.91397101474502e-09 -0.347426428894746 0.000431581051522446 miRanda -0.0799483513574316 0.0102298550747287 NA NA NA hsa-miR-320b CFLAR 1.23473838180754 3.04337566045537e-14 -0.347426428894746 0.000431581051522446 miRanda -0.0900612795693767 0.000488935804751288 NA NA NA hsa-miR-339-5p CFLAR 1.07771430326938 2.45772601859307e-09 -0.347426428894746 0.000431581051522446 miRanda -0.0792064717064564 0.000736962720819571 NA NA NA hsa-miR-34c-5p CFLAR 0.565896455062849 0.0224052732281715 -0.347426428894746 0.000431581051522446 miRanda -0.0674690076279489 9.72958360160029e-05 NA NA NA hsa-miR-374b-5p CFLAR -0.288413933608091 0.0041474558664058 -0.347426428894746 0.000431581051522446 MirTarget -0.087157475761209 0.0437611696715675 NA NA NA hsa-miR-421 CFLAR 0.945488088619653 2.35762398527362e-09 -0.347426428894746 0.000431581051522446 miRanda -0.095232009035911 0.000394731060653648 NA NA NA hsa-miR-454-3p CFLAR 1.54137391927201 4.15861570449376e-20 -0.347426428894746 0.000431581051522446 mirMAP -0.0524978306925033 0.0341943845614655 NA NA NA hsa-miR-550a-5p CFLAR 1.48775474412835 6.14204462566372e-18 -0.347426428894746 0.000431581051522446 mirMAP -0.0603808126038431 0.0126629795122247 NA NA NA hsa-miR-708-5p CFLAR 1.54207894190626 2.2887257992285e-19 -0.347426428894746 0.000431581051522446 mirMAP -0.120017448631449 6.20095321635461e-07 NA NA NA hsa-miR-582-5p CHP2 -0.0366995972742474 0.821827119138923 0.0324994864946184 0.945726630990573 miRNATAP -0.301212684713048 0.0186800131088629 NA NA NA hsa-miR-15a-5p CHUK 0.783550182002274 2.60699595655907e-11 0.0500477559396222 0.472918197228855 miRNAWalker2_validate;miRTarBase;MirTarget -0.0980683810286944 0.000102688891822285 NA NA NA hsa-miR-342-3p CHUK 0.99756868977753 9.28499866272332e-10 0.0500477559396222 0.472918197228855 miRanda -0.0629470190706229 0.00054911205185509 NA NA NA hsa-miR-125a-5p CSF2RB 0.215366061934933 0.119550904549401 -0.372030110911936 0.0859683504965578 miRanda -0.138063422566594 0.0442491818788832 NA NA NA hsa-miR-19a-3p CSF2RB 1.35800152353624 2.80940447111944e-12 -0.372030110911936 0.0859683504965578 MirTarget -0.320861956956304 6.14762600843802e-12 NA NA NA hsa-miR-19b-3p CSF2RB 0.538732279378089 0.000622008277870679 -0.372030110911936 0.0859683504965578 MirTarget -0.359322825161025 1.13744786185385e-09 NA NA NA hsa-miR-452-3p CSF2RB 1.09618110917892 2.21867884261816e-07 -0.372030110911936 0.0859683504965578 mirMAP -0.199677061117346 5.22034394239656e-06 NA NA NA hsa-miR-455-5p CSF2RB 1.408595672323 5.52039116456697e-22 -0.372030110911936 0.0859683504965578 miRanda -0.352399241717837 9.26746136503431e-09 NA NA NA hsa-miR-485-3p CSF2RB 0.359155046663542 0.0929405338270575 -0.372030110911936 0.0859683504965578 MirTarget -0.11667537351305 0.00860054183506795 NA NA NA hsa-miR-493-3p CSF2RB -0.588568690467072 0.00436360724637211 -0.372030110911936 0.0859683504965578 MirTarget -0.119122854389741 0.0091846637598177 NA NA NA hsa-miR-576-5p CSF2RB 0.940432050128373 6.90227595663302e-12 -0.372030110911936 0.0859683504965578 miRNATAP -0.190683686661979 0.00484263176970127 NA NA NA hsa-miR-125a-3p CYCS 0.116035800853173 0.444825559956959 -0.134141810341233 0.133947101630507 miRanda -0.107410555046087 2.65589206099304e-05 NA NA NA hsa-miR-127-3p DFFA -1.47175957435172 9.8707469067377e-14 0.105736025515859 0.166662380846828 miRanda -0.0736864005092424 5.83501178153411e-06 NA NA NA hsa-miR-129-5p DFFA -0.246329588499478 0.436451191224681 0.105736025515859 0.166662380846828 miRanda;mirMAP -0.0537976794165878 3.32662035556627e-07 NA NA NA hsa-miR-145-5p DFFA -0.46917511594055 0.000685297625493134 0.105736025515859 0.166662380846828 miRNAWalker2_validate;miRTarBase -0.0901810450672881 0.000161837131573681 NA NA NA hsa-miR-148a-3p DFFA -0.428944290834563 0.00954246923521465 0.105736025515859 0.166662380846828 mirMAP -0.0942245007095501 2.16348644622867e-06 NA NA NA hsa-miR-26a-2-3p DFFA -0.444498687388748 0.00325793861409413 0.105736025515859 0.166662380846828 mirMAP -0.0547171563545117 0.0127944019554233 NA NA NA hsa-miR-26a-5p DFFA -1.09269574587169 1.24020612216319e-22 0.105736025515859 0.166662380846828 mirMAP -0.17106214148135 1.3732963380354e-09 NA NA NA hsa-miR-30a-3p DFFA -2.26144364746452 8.12421214153823e-31 0.105736025515859 0.166662380846828 mirMAP -0.062285842085678 8.66364477068542e-05 NA NA NA hsa-miR-30e-3p DFFA -0.890635378639789 1.65740480611339e-16 0.105736025515859 0.166662380846828 mirMAP -0.084611760949432 0.00477378873393498 NA NA NA hsa-miR-374a-5p DFFA -0.621903385111545 6.61791773205282e-12 0.105736025515859 0.166662380846828 mirMAP -0.0752599528352906 0.0383749594830708 NA NA NA hsa-miR-374b-5p DFFA -0.288413933608091 0.0041474558664058 0.105736025515859 0.166662380846828 mirMAP -0.114544627080415 0.000543619202924725 NA NA NA hsa-miR-3913-5p DFFA 0.48532077857571 0.00112373589405304 0.105736025515859 0.166662380846828 mirMAP -0.0753772416372116 0.000718306569413649 NA NA NA hsa-miR-409-3p DFFA -0.342347118512604 0.0538776384301546 0.105736025515859 0.166662380846828 mirMAP -0.0562621610321265 0.0025800369398346 NA NA NA hsa-miR-628-5p DFFA -0.554239048796013 4.92386883216087e-05 0.105736025515859 0.166662380846828 mirMAP -0.113497133930664 2.36456784428979e-06 NA NA NA hsa-miR-664a-3p DFFA -0.256108763664991 0.0513188660751664 0.105736025515859 0.166662380846828 mirMAP -0.0906750604744997 0.000331927282309129 NA NA NA hsa-miR-365a-3p DFFB 0.446833934952926 0.00233857759218299 0.129509285951802 0.256772504319122 MirTarget -0.146927309322918 1.24526977792996e-05 NA NA NA hsa-miR-130b-3p ENDOD1 1.44628430084411 9.13980959861273e-24 -0.553669426594082 0.000142258238042726 MirTarget -0.322106144889491 6.8308081189012e-15 NA NA NA hsa-miR-16-1-3p ENDOD1 0.955017760172879 5.95379292601146e-11 -0.553669426594082 0.000142258238042726 mirMAP -0.338192613408499 7.02341369396328e-16 NA NA NA hsa-miR-181c-5p ENDOD1 -0.168991199007857 0.196949106150297 -0.553669426594082 0.000142258238042726 MirTarget -0.319746780641142 2.8632248696448e-11 NA NA NA hsa-miR-181d-5p ENDOD1 0.367649966373544 0.00537300571455306 -0.553669426594082 0.000142258238042726 MirTarget -0.208940357859226 1.39360101432439e-05 NA NA NA hsa-miR-192-5p ENDOD1 0.380924502586635 0.00986961967409205 -0.553669426594082 0.000142258238042726 miRNAWalker2_validate -0.284088931003441 2.21013834193796e-11 NA NA NA hsa-miR-19a-3p ENDOD1 1.35800152353624 2.80940447111944e-12 -0.553669426594082 0.000142258238042726 mirMAP -0.142435769646021 8.03008841490871e-06 NA NA NA hsa-miR-19b-3p ENDOD1 0.538732279378089 0.000622008277870679 -0.553669426594082 0.000142258238042726 mirMAP -0.18067658252998 6.79077589821979e-06 NA NA NA hsa-miR-200b-3p ENDOD1 0.0717138787925347 0.682858087587209 -0.553669426594082 0.000142258238042726 TargetScan -0.235458038384682 4.68654736705351e-11 NA NA NA hsa-miR-205-3p ENDOD1 1.2960640797621 5.80786479909147e-11 -0.553669426594082 0.000142258238042726 mirMAP -0.132096850203253 2.66736302880862e-05 NA NA NA hsa-miR-20a-3p ENDOD1 1.34885093664027 2.07697464119202e-12 -0.553669426594082 0.000142258238042726 MirTarget -0.102118842788045 0.00165776173315135 NA NA NA hsa-miR-26b-3p ENDOD1 0.421575313079363 0.00223298166810883 -0.553669426594082 0.000142258238042726 mirMAP -0.181154196932965 8.42152711975917e-05 NA NA NA hsa-miR-301a-3p ENDOD1 2.14132004241926 4.46255413526808e-25 -0.553669426594082 0.000142258238042726 MirTarget -0.0881211887591515 0.00263046545982347 NA NA NA hsa-miR-330-5p ENDOD1 0.944693925383906 5.04972895657346e-13 -0.553669426594082 0.000142258238042726 miRanda -0.146358044774559 0.0021860781418413 NA NA NA hsa-miR-335-3p ENDOD1 0.336785882180547 0.0542446207938138 -0.553669426594082 0.000142258238042726 MirTarget -0.194155270343332 7.39956700725951e-08 NA NA NA hsa-miR-3607-3p ENDOD1 1.01377165357363 9.13355519701165e-05 -0.553669426594082 0.000142258238042726 MirTarget;miRNATAP -0.127326778542306 1.45370874242559e-07 NA NA NA hsa-miR-361-5p ENDOD1 0.0803683277369505 0.314043140368058 -0.553669426594082 0.000142258238042726 MirTarget;miRanda -0.192915826549144 0.0177689044256056 NA NA NA hsa-miR-3613-5p ENDOD1 0.410363235348614 0.00534956684590092 -0.553669426594082 0.000142258238042726 MirTarget -0.200681059727944 3.02884332343231e-06 NA NA NA hsa-miR-362-3p ENDOD1 -0.697212068252854 2.61718493418184e-06 -0.553669426594082 0.000142258238042726 miRanda -0.106704357200331 0.0128299327411775 NA NA NA hsa-miR-429 ENDOD1 0.559451508722375 0.00563641638673083 -0.553669426594082 0.000142258238042726 miRanda;miRNATAP -0.181112373943104 5.57352237012288e-09 NA NA NA hsa-miR-454-3p ENDOD1 1.54137391927201 4.15861570449376e-20 -0.553669426594082 0.000142258238042726 MirTarget -0.161716461133009 8.79186351439732e-06 NA NA NA hsa-miR-589-3p ENDOD1 1.59559692667315 6.2886410639161e-15 -0.553669426594082 0.000142258238042726 mirMAP -0.0923496437920279 0.00343987434247041 NA NA NA hsa-miR-589-5p ENDOD1 0.807877250867909 4.12262850391353e-14 -0.553669426594082 0.000142258238042726 MirTarget -0.304772220449199 1.48685459704457e-07 NA NA NA hsa-miR-590-3p ENDOD1 0.221436901462551 0.0965904764063157 -0.553669426594082 0.000142258238042726 miRanda -0.282799248173601 2.40254520465731e-09 NA NA NA hsa-miR-10b-3p EXOG -0.543047860786312 3.05094088463161e-06 0.346477529196855 7.39766713401986e-05 MirTarget -0.089557365531779 0.00625631265936318 NA NA NA hsa-miR-24-3p EXOG 0.13115428390042 0.203891651275156 0.346477529196855 7.39766713401986e-05 MirTarget -0.187152654796317 4.41307976918044e-07 NA NA NA hsa-miR-146a-5p FADD -0.0201236699646614 0.905882759106561 1.28423879344217 2.33501183649312e-11 miRNAWalker2_validate;miRTarBase -0.132971420758236 0.00823833568229994 NA NA NA hsa-miR-155-5p FADD 0.533437622040649 0.00248671179205372 1.28423879344217 2.33501183649312e-11 miRTarBase -0.100053136539527 0.0387571521844899 NA NA NA hsa-miR-28-5p FADD -0.026996999089909 0.733047113251652 1.28423879344217 2.33501183649312e-11 miRanda -0.219019322553433 0.0468068017238003 NA NA NA hsa-miR-3065-3p FADD -0.543069092777161 0.0213164885178151 1.28423879344217 2.33501183649312e-11 MirTarget -0.0836939529975975 0.0206880784960152 NA NA NA hsa-miR-129-5p FAS -0.246329588499478 0.436451191224681 -0.353746390296431 0.0224836395610983 miRanda -0.0919992352817555 1.9915778857292e-05 NA NA NA hsa-miR-361-5p FAS 0.0803683277369505 0.314043140368058 -0.353746390296431 0.0224836395610983 miRanda -0.254638067114056 0.00313062697979385 NA NA NA hsa-miR-590-5p FAS 0.763025362395968 3.65305892505623e-09 -0.353746390296431 0.0224836395610983 miRanda -0.179002441556527 0.000520949899474374 NA NA NA hsa-miR-98-5p FAS 0.0176698653376732 0.858271091070735 -0.353746390296431 0.0224836395610983 miRNAWalker2_validate -0.14040192647554 0.0424993258234579 NA NA NA hsa-let-7e-5p FASLG 0.0857356192778891 0.512869729833211 0.394703525705912 0.21882393973136 miRNATAP -0.353388568642215 0.000974735688504158 NA NA NA hsa-miR-199a-5p FASLG -0.364835768178638 0.0435119211101981 0.394703525705912 0.21882393973136 miRanda -0.273318512204072 0.000400614015733864 NA NA NA hsa-miR-324-5p FASLG 1.66709479707179 1.45961450445769e-23 0.394703525705912 0.21882393973136 miRanda -0.20624596801537 0.0102424555657243 NA NA NA hsa-miR-452-3p FASLG 1.09618110917892 2.21867884261816e-07 0.394703525705912 0.21882393973136 mirMAP -0.298192608882689 4.3334365675638e-06 NA NA NA hsa-miR-92a-3p FASLG 0.994679542307232 1.32587679156217e-16 0.394703525705912 0.21882393973136 miRNATAP -0.270028595597889 0.0173238686407533 NA NA NA hsa-miR-125a-3p IKBKB 0.116035800853173 0.444825559956959 -0.396740795566287 2.1815201064403e-05 miRanda -0.108503103251697 5.57509033653017e-05 NA NA NA hsa-miR-151a-3p IKBKB 0.131002217498676 0.295273522160941 -0.396740795566287 2.1815201064403e-05 miRNAWalker2_validate -0.104928278750609 0.00139735412928447 NA NA NA hsa-miR-542-3p IKBKB 0.643308814904977 8.81635403230104e-07 -0.396740795566287 2.1815201064403e-05 miRanda -0.164952079150207 8.30758678680247e-08 NA NA NA hsa-miR-107 IKBKG -0.0447040564279497 0.671618791096755 0.570547337190534 1.55778741154943e-10 miRanda -0.193473702960341 2.35749871093699e-07 NA NA NA hsa-miR-143-3p IKBKG -1.33760181792708 4.15335119989612e-12 0.570547337190534 1.55778741154943e-10 mirMAP -0.136024640433278 4.28001868046101e-12 NA NA NA hsa-miR-24-3p IKBKG 0.13115428390042 0.203891651275156 0.570547337190534 1.55778741154943e-10 mirMAP -0.0881167026955101 0.0225324482128781 NA NA NA hsa-miR-29c-3p IKBKG -2.08166260448948 8.3238369390898e-24 0.570547337190534 1.55778741154943e-10 mirMAP -0.0817135990056937 6.27083585960972e-06 NA NA NA hsa-miR-330-3p IKBKG -0.0524949332825773 0.719856123539461 0.570547337190534 1.55778741154943e-10 mirMAP -0.0915181424578811 0.000713341691900887 NA NA NA hsa-miR-335-5p IKBKG -1.17227779671552 1.49282618530733e-10 0.570547337190534 1.55778741154943e-10 mirMAP -0.0660175150902567 0.00181106345430361 NA NA NA hsa-miR-338-5p IKBKG -1.71946558699173 2.62649071488641e-23 0.570547337190534 1.55778741154943e-10 mirMAP -0.122404174241048 1.41142850944174e-08 NA NA NA hsa-miR-376c-3p IKBKG -1.70422793441579 1.16555506116207e-15 0.570547337190534 1.55778741154943e-10 mirMAP -0.0620784380897571 0.000556168186302728 NA NA NA hsa-miR-377-5p IKBKG -1.69097705663616 5.63934319114725e-15 0.570547337190534 1.55778741154943e-10 mirMAP -0.0689604629327797 0.000125879546399438 NA NA NA hsa-miR-432-5p IKBKG -1.37745409934142 1.95995628572162e-09 0.570547337190534 1.55778741154943e-10 mirMAP -0.0576297712208843 0.000653096943052031 NA NA NA hsa-miR-140-5p IL1A -0.412389003031485 0.000136051708543369 2.00781280937654 2.39057383153864e-08 miRanda -0.463443253369586 0.00164689764755682 NA NA NA hsa-miR-181c-5p IL1A -0.168991199007857 0.196949106150297 2.00781280937654 2.39057383153864e-08 MirTarget -0.782886423215508 6.75756008155393e-11 NA NA NA hsa-miR-181d-5p IL1A 0.367649966373544 0.00537300571455306 2.00781280937654 2.39057383153864e-08 MirTarget -0.560619915059391 2.86075725406214e-06 NA NA NA hsa-miR-30a-5p IL1A -1.79779915425811 1.93360169837799e-26 2.00781280937654 2.39057383153864e-08 MirTarget -0.539003354188258 9.90088532260576e-10 NA NA NA hsa-miR-30b-5p IL1A -0.400238605368173 0.00346540992719245 2.00781280937654 2.39057383153864e-08 MirTarget -0.427928657146442 0.000221837776414958 NA NA NA hsa-miR-30d-5p IL1A -0.38399848121878 0.000171129616944749 2.00781280937654 2.39057383153864e-08 MirTarget -0.87176581079203 1.63368954450137e-08 NA NA NA hsa-miR-30e-5p IL1A -1.02114836019762 6.81961221797866e-17 2.00781280937654 2.39057383153864e-08 MirTarget -0.773246098522638 5.73332426287182e-10 NA NA NA hsa-miR-335-5p IL1A -1.17227779671552 1.49282618530733e-10 2.00781280937654 2.39057383153864e-08 miRNAWalker2_validate -0.510440454529664 1.33927056615795e-09 NA NA NA hsa-miR-493-5p IL1A -0.471586962917071 0.0221327433064002 2.00781280937654 2.39057383153864e-08 MirTarget -0.255026715020076 0.000936161326846365 NA NA NA hsa-miR-532-5p IL1A -0.021857649390892 0.830992272120134 2.00781280937654 2.39057383153864e-08 MirTarget -0.725499738545333 3.22575781197608e-06 NA NA NA hsa-miR-664a-3p IL1A -0.256108763664991 0.0513188660751664 2.00781280937654 2.39057383153864e-08 MirTarget -0.513123540284563 2.16945611283765e-05 NA NA NA hsa-miR-30a-3p IL1B -2.26144364746452 8.12421214153823e-31 0.985214888218113 0.000346207862322016 MirTarget -0.229852864730208 6.79100302627562e-05 NA NA NA hsa-miR-30e-3p IL1B -0.890635378639789 1.65740480611339e-16 0.985214888218113 0.000346207862322016 MirTarget -0.357623602024864 0.00102451793076387 NA NA NA hsa-miR-495-3p IL1B -1.47803501311999 6.88839745293927e-13 0.985214888218113 0.000346207862322016 MirTarget -0.268600495864042 2.48090523925614e-06 NA NA NA hsa-miR-130b-5p IL1R1 1.77265255049999 1.43627774829684e-29 -0.258477920400496 0.0877609962203384 mirMAP -0.139670672212031 0.000421618347532264 NA NA NA hsa-miR-17-3p IL1R1 -0.0127974722290336 0.909559935689875 -0.258477920400496 0.0877609962203384 mirMAP -0.461807121039164 9.08394287544504e-16 NA NA NA hsa-miR-186-5p IL1R1 0.353452958261612 0.000145058448579496 -0.258477920400496 0.0877609962203384 mirMAP -0.386553072720816 4.29792380331471e-08 NA NA NA hsa-miR-192-5p IL1R1 0.380924502586635 0.00986961967409205 -0.258477920400496 0.0877609962203384 miRNAWalker2_validate -0.161167488746724 0.000301106587755486 NA NA NA hsa-miR-197-3p IL1R1 0.878693269130833 3.84847526014135e-15 -0.258477920400496 0.0877609962203384 miRNAWalker2_validate -0.205631080664336 0.000358047432482296 NA NA NA hsa-miR-26b-5p IL1R1 -0.254478038884324 0.0285227763044636 -0.258477920400496 0.0877609962203384 mirMAP -0.274490276032267 1.25081787637527e-06 NA NA NA hsa-miR-30d-3p IL1R1 -0.577371911152798 2.02950840095287e-06 -0.258477920400496 0.0877609962203384 mirMAP -0.351357852961884 4.10939728424481e-11 NA NA NA hsa-miR-335-3p IL1R1 0.336785882180547 0.0542446207938138 -0.258477920400496 0.0877609962203384 mirMAP -0.174812331888298 3.05441157376742e-06 NA NA NA hsa-miR-361-5p IL1R1 0.0803683277369505 0.314043140368058 -0.258477920400496 0.0877609962203384 miRanda -0.277211246579818 0.000964849416429579 NA NA NA hsa-miR-590-3p IL1R1 0.221436901462551 0.0965904764063157 -0.258477920400496 0.0877609962203384 miRanda;miRNATAP -0.210628181729486 2.03716482577516e-05 NA NA NA hsa-miR-944 IL1R1 1.47323925060177 2.61626403984929e-13 -0.258477920400496 0.0877609962203384 mirMAP -0.0765693738179228 0.0166701374264178 NA NA NA hsa-miR-106a-5p IL1RAP 0.67978010057847 0.00221925869726092 0.493350312117789 0.00341295743785046 MirTarget -0.121006818872304 0.000236188269356637 NA NA NA hsa-miR-106b-5p IL1RAP 0.50378717276868 1.45412404526866e-05 0.493350312117789 0.00341295743785046 MirTarget -0.126869472893198 0.0452912735970859 NA NA NA hsa-miR-140-5p IL1RAP -0.412389003031485 0.000136051708543369 0.493350312117789 0.00341295743785046 miRanda -0.236377942215799 0.00051907336357703 NA NA NA hsa-miR-17-5p IL1RAP 1.41924888736771 2.75805544953758e-18 0.493350312117789 0.00341295743785046 MirTarget;TargetScan -0.125485425185265 0.00413044673198014 NA NA NA hsa-miR-186-5p IL1RAP 0.353452958261612 0.000145058448579496 0.493350312117789 0.00341295743785046 mirMAP -0.257474311578976 0.00120165508555335 NA NA NA hsa-miR-190a-5p IL1RAP -1.30388078255037 2.03085944415788e-14 0.493350312117789 0.00341295743785046 MirTarget -0.102956824230857 0.0150612398349474 NA NA NA hsa-miR-192-5p IL1RAP 0.380924502586635 0.00986961967409205 0.493350312117789 0.00341295743785046 miRNAWalker2_validate -0.13506948204378 0.00680832043439986 NA NA NA hsa-miR-199a-5p IL1RAP -0.364835768178638 0.0435119211101981 0.493350312117789 0.00341295743785046 miRanda -0.105578749738656 0.00958008218908708 NA NA NA hsa-miR-199b-5p IL1RAP -1.08432682485992 7.68241801134089e-10 0.493350312117789 0.00341295743785046 miRanda -0.113682435372398 0.00568444357471556 NA NA NA hsa-miR-19a-3p IL1RAP 1.35800152353624 2.80940447111944e-12 0.493350312117789 0.00341295743785046 MirTarget -0.136199651932138 0.000228566068717045 NA NA NA hsa-miR-19b-3p IL1RAP 0.538732279378089 0.000622008277870679 0.493350312117789 0.00341295743785046 MirTarget -0.241012462340721 1.83849633965992e-07 NA NA NA hsa-miR-20a-5p IL1RAP 1.1531986665452 1.02385132917958e-11 0.493350312117789 0.00341295743785046 MirTarget -0.171629516517212 5.20109427006645e-05 NA NA NA hsa-miR-20b-5p IL1RAP 0.345967670847176 0.232014828043601 0.493350312117789 0.00341295743785046 MirTarget -0.162305926273287 8.70193293588671e-11 NA NA NA hsa-miR-217 IL1RAP -1.35391381055929 2.42394951427902e-09 0.493350312117789 0.00341295743785046 miRanda -0.118396424019506 0.00019876562400479 NA NA NA hsa-miR-29b-3p IL1RAP -0.110721443686039 0.511264554091106 0.493350312117789 0.00341295743785046 MirTarget;miRNATAP -0.18981668071141 1.303387041897e-05 NA NA NA hsa-miR-29c-3p IL1RAP -2.08166260448948 8.3238369390898e-24 0.493350312117789 0.00341295743785046 MirTarget;miRNATAP -0.0934178285177407 0.00594904661685718 NA NA NA hsa-miR-301a-3p IL1RAP 2.14132004241926 4.46255413526808e-25 0.493350312117789 0.00341295743785046 MirTarget -0.0815981982860349 0.0160433816000071 NA NA NA hsa-miR-320a IL1RAP 0.801356001806321 4.91397101474502e-09 0.493350312117789 0.00341295743785046 MirTarget;PITA;miRanda -0.264907247270334 4.95414548520158e-07 NA NA NA hsa-miR-320b IL1RAP 1.23473838180754 3.04337566045537e-14 0.493350312117789 0.00341295743785046 MirTarget;PITA;miRanda -0.108757931944332 0.0139382313143776 NA NA NA hsa-miR-335-3p IL1RAP 0.336785882180547 0.0542446207938138 0.493350312117789 0.00341295743785046 mirMAP -0.17253773149529 3.83790370084706e-05 NA NA NA hsa-miR-339-5p IL1RAP 1.07771430326938 2.45772601859307e-09 0.493350312117789 0.00341295743785046 miRanda -0.104300068311027 0.00939170484885258 NA NA NA hsa-miR-3607-3p IL1RAP 1.01377165357363 9.13355519701165e-05 0.493350312117789 0.00341295743785046 mirMAP -0.0840893105249321 0.00288121441845191 NA NA NA hsa-miR-361-5p IL1RAP 0.0803683277369505 0.314043140368058 0.493350312117789 0.00341295743785046 miRanda -0.260180827467688 0.00559143747948556 NA NA NA hsa-miR-362-3p IL1RAP -0.697212068252854 2.61718493418184e-06 0.493350312117789 0.00341295743785046 miRanda -0.172988023396244 0.000459511818282594 NA NA NA hsa-miR-454-3p IL1RAP 1.54137391927201 4.15861570449376e-20 0.493350312117789 0.00341295743785046 MirTarget -0.147637559203462 0.000463308247812837 NA NA NA hsa-miR-590-5p IL1RAP 0.763025362395968 3.65305892505623e-09 0.493350312117789 0.00341295743785046 miRanda -0.149330465424413 0.00800897147377789 NA NA NA hsa-miR-664a-3p IL1RAP -0.256108763664991 0.0513188660751664 0.493350312117789 0.00341295743785046 mirMAP -0.369642268416535 2.2082248361599e-11 NA NA NA hsa-miR-93-5p IL1RAP 1.61042951896619 5.1280369606967e-24 0.493350312117789 0.00341295743785046 MirTarget -0.178991526748267 4.7099515167665e-05 NA NA NA hsa-miR-146a-5p IRAK1 -0.0201236699646614 0.905882759106561 0.564125479399179 2.77041674280105e-10 miRNAWalker2_validate;miRTarBase -0.0893280077022376 0.000118422852522778 25242818;22846912;21632853 Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;Functional analysis revealed that miR-146a rs2910164 C allele inhibited cell proliferation and significantly downregulated expression of IRAK1 and TRAF6 in bladder cancer cells;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;; pancreatic cancer;bladder cancer;gastric cancer hsa-miR-192-5p IRAK1 0.380924502586635 0.00986961967409205 0.564125479399179 2.77041674280105e-10 miRNAWalker2_validate -0.0553330916418678 0.0392812609909751 NA NA NA hsa-miR-215-5p IRAK1 -0.757663683237828 5.72998183244808e-05 0.564125479399179 2.77041674280105e-10 miRNAWalker2_validate -0.0700175487798947 0.000837912118252881 NA NA NA hsa-miR-328-3p IRAK1 0.153404163477345 0.292356842798574 0.564125479399179 2.77041674280105e-10 miRNAWalker2_validate -0.0591526605593756 0.0300855961607562 NA NA NA hsa-miR-339-5p IRAK2 1.07771430326938 2.45772601859307e-09 -0.401726727753225 0.0245140169079557 miRanda -0.129815390101373 0.00222656759454902 NA NA NA hsa-miR-450b-5p IRAK2 1.25529820885833 1.18847120528666e-15 -0.401726727753225 0.0245140169079557 PITA -0.226216355451031 2.47775760295614e-06 NA NA NA hsa-miR-141-3p IRAK3 0.730011517758706 0.000120338355004032 -0.223759013344381 0.277212592886235 mirMAP -0.191700327671694 4.16797193896411e-05 NA NA NA hsa-miR-148b-5p IRAK3 1.1533193737265 7.26420964688337e-13 -0.223759013344381 0.277212592886235 mirMAP -0.132938282758655 0.0163050449406045 NA NA NA hsa-miR-188-5p IRAK3 0.559328953885106 0.000430338888594543 -0.223759013344381 0.277212592886235 mirMAP -0.171386831293707 0.00241191776171964 NA NA NA hsa-miR-200a-3p IRAK3 0.607140814457753 0.00289840524858752 -0.223759013344381 0.277212592886235 mirMAP -0.134991556202382 0.00206482601511599 NA NA NA hsa-miR-205-5p IRAK3 1.50759485376634 2.0003886738248e-16 -0.223759013344381 0.277212592886235 mirMAP -0.236148673589877 5.23653204585698e-07 NA NA NA hsa-miR-20a-3p IRAK3 1.34885093664027 2.07697464119202e-12 -0.223759013344381 0.277212592886235 mirMAP -0.221843414789607 1.01054723653287e-06 NA NA NA hsa-miR-324-5p IRAK3 1.66709479707179 1.45961450445769e-23 -0.223759013344381 0.277212592886235 miRanda -0.26747173965888 1.56114381841468e-07 NA NA NA hsa-miR-33a-5p IRAK3 1.12988965056352 3.35742517382153e-07 -0.223759013344381 0.277212592886235 mirMAP -0.158025715961326 7.3908306517167e-05 NA NA NA hsa-miR-429 IRAK3 0.559451508722375 0.00563641638673083 -0.223759013344381 0.277212592886235 miRanda -0.122831835902799 0.00552059621818287 NA NA NA hsa-miR-452-3p IRAK3 1.09618110917892 2.21867884261816e-07 -0.223759013344381 0.277212592886235 mirMAP -0.214841993845537 2.25494963122705e-07 NA NA NA hsa-miR-501-5p IRAK3 1.02806906860218 1.63456814370548e-09 -0.223759013344381 0.277212592886235 mirMAP -0.191574704508929 0.000255938031363533 NA NA NA hsa-miR-589-3p IRAK3 1.59559692667315 6.2886410639161e-15 -0.223759013344381 0.277212592886235 mirMAP -0.124502658212278 0.00507366794635527 NA NA NA hsa-miR-590-5p IRAK3 0.763025362395968 3.65305892505623e-09 -0.223759013344381 0.277212592886235 mirMAP -0.299347730395012 1.13870295782553e-05 NA NA NA hsa-miR-660-5p IRAK3 -0.202705992887645 0.101093376073573 -0.223759013344381 0.277212592886235 mirMAP -0.229635416567457 0.00161717495476459 NA NA NA hsa-miR-708-3p IRAK3 1.32647174389322 4.87465491977979e-16 -0.223759013344381 0.277212592886235 mirMAP -0.272817058152577 2.44006428438873e-07 NA NA NA hsa-miR-92a-3p IRAK3 0.994679542307232 1.32587679156217e-16 -0.223759013344381 0.277212592886235 mirMAP -0.322289802954015 8.19326712014552e-06 NA NA NA hsa-miR-944 IRAK3 1.47323925060177 2.61626403984929e-13 -0.223759013344381 0.277212592886235 mirMAP -0.250267245869394 5.48080184932547e-09 NA NA NA hsa-miR-193a-3p IRAK4 0.22120710726779 0.111827069464729 -0.272079061671418 0.000818572556304455 miRanda -0.0843326663000673 0.000954413160506387 NA NA NA hsa-miR-320a IRAK4 0.801356001806321 4.91397101474502e-09 -0.272079061671418 0.000818572556304455 miRanda -0.058479455717022 0.0224105418076689 NA NA NA hsa-miR-421 IRAK4 0.945488088619653 2.35762398527362e-09 -0.272079061671418 0.000818572556304455 miRanda -0.0690430264272894 0.0018034531915965 NA NA NA hsa-miR-493-5p IRAK4 -0.471586962917071 0.0221327433064002 -0.272079061671418 0.000818572556304455 mirMAP -0.0813964803710649 1.89763771663869e-06 NA NA NA hsa-miR-17-5p MAP3K14 1.41924888736771 2.75805544953758e-18 -0.820531706687164 8.24898608505683e-10 MirTarget -0.180703236855232 2.16010787102818e-07 NA NA NA hsa-miR-20a-5p MAP3K14 1.1531986665452 1.02385132917958e-11 -0.820531706687164 8.24898608505683e-10 MirTarget -0.122103687330653 0.000348942989232876 NA NA NA hsa-miR-34c-5p MAP3K14 0.565896455062849 0.0224052732281715 -0.820531706687164 8.24898608505683e-10 MirTarget -0.054101206371395 0.0234188796043038 NA NA NA hsa-miR-429 MAP3K14 0.559451508722375 0.00563641638673083 -0.820531706687164 8.24898608505683e-10 miRNATAP -0.09654389275763 0.000928558216381731 NA NA NA hsa-miR-542-3p MAP3K14 0.643308814904977 8.81635403230104e-07 -0.820531706687164 8.24898608505683e-10 miRanda -0.141071427870492 0.00167669092004037 27107696 miR 542 3p suppresses invasion and metastasis by targeting the proto oncogene serine/threonine protein kinase PIM1 in melanoma; The proto-oncogene serine/threonine protein kinase PIM1 was identified as a direct target of miR-542-3p using luciferase reporter assay qRT-PCR and western blot analyses metastasis melanoma hsa-miR-93-5p MAP3K14 1.61042951896619 5.1280369606967e-24 -0.820531706687164 8.24898608505683e-10 MirTarget -0.0827703299583342 0.0198474129990229 NA NA NA hsa-miR-138-5p MYD88 0.702468796115049 0.0082478986123581 -0.391982270996858 0.000316472665478512 MirTarget -0.056620243009711 0.0028687644832648 NA NA NA hsa-miR-429 MYD88 0.559451508722375 0.00563641638673083 -0.391982270996858 0.000316472665478512 miRanda -0.111290606089515 1.81671729605663e-06 NA NA NA hsa-miR-491-5p MYD88 -0.541680329196715 0.00135829217561865 -0.391982270996858 0.000316472665478512 miRanda -0.0773516380686446 0.00852806072131908 NA NA NA hsa-miR-660-5p MYD88 -0.202705992887645 0.101093376073573 -0.391982270996858 0.000316472665478512 MirTarget -0.0938259669825944 0.0153872613469876 NA NA NA hsa-miR-15a-5p NFKB1 0.783550182002274 2.60699595655907e-11 -0.0586166405595643 0.532939439102198 miRNAWalker2_validate -0.100524054629175 0.00332260332322556 NA NA NA hsa-miR-199a-5p NFKB1 -0.364835768178638 0.0435119211101981 -0.0586166405595643 0.532939439102198 miRanda -0.089609845985693 6.80412751317393e-05 18408758 Regulation of IKKbeta by miR 199a affects NF kappaB activity in ovarian cancer cells ovarian cancer hsa-miR-199b-5p NFKB1 -1.08432682485992 7.68241801134089e-10 -0.0586166405595643 0.532939439102198 miRanda -0.0743188637458754 0.00109334580205244 NA NA NA hsa-miR-338-3p NFKB1 -0.948755228846395 8.99167125682392e-08 -0.0586166405595643 0.532939439102198 miRanda -0.0537429524485075 0.018210814096096 NA NA NA hsa-miR-429 NFKB1 0.559451508722375 0.00563641638673083 -0.0586166405595643 0.532939439102198 miRanda;miRNATAP -0.0546253211118997 0.00670921878984588 NA NA NA hsa-miR-671-5p NFKB1 1.90920358947989 6.8158317757852e-31 -0.0586166405595643 0.532939439102198 MirTarget -0.0873984361511921 0.000165306779466518 NA NA NA hsa-let-7b-5p NFKBIA -0.2489842756826 0.0211384499461719 0.23343819644764 0.0512507671362499 miRNAWalker2_validate -0.110316267797241 0.0233914922423826 NA NA NA hsa-miR-381-3p NFKBIA -2.21357103508055 2.33039447871705e-24 0.23343819644764 0.0512507671362499 MirTarget -0.120459167764438 1.04306651481543e-07 NA NA NA hsa-let-7c-5p NGF -2.07953368242668 3.46048888391218e-23 1.08938604562817 0.00258107261776762 MirTarget -0.474331709252181 2.09923806999807e-11 NA NA NA hsa-let-7d-5p NGF 0.481757661442508 3.66030810124939e-07 1.08938604562817 0.00258107261776762 MirTarget -0.66981065797809 5.57819243832775e-05 NA NA NA hsa-let-7f-5p NGF -0.441845198213823 0.00242957484218694 1.08938604562817 0.00258107261776762 MirTarget -0.246976150148099 0.0229311047263193 NA NA NA hsa-let-7g-5p NGF -0.250780249469264 0.00939610188330072 1.08938604562817 0.00258107261776762 MirTarget -1.0538459376691 8.8206138464407e-11 NA NA NA hsa-miR-320a NGF 0.801356001806321 4.91397101474502e-09 1.08938604562817 0.00258107261776762 miRanda -0.394376196453096 0.000532905541066623 NA NA NA hsa-miR-320b NGF 1.23473838180754 3.04337566045537e-14 1.08938604562817 0.00258107261776762 miRanda -0.4625048476379 9.04690456635774e-07 NA NA NA hsa-miR-423-5p NGF 0.60141781325829 1.62940950644999e-07 1.08938604562817 0.00258107261776762 MirTarget;miRNATAP -0.412248193811393 0.00259074860264355 NA NA NA hsa-miR-429 NGF 0.559451508722375 0.00563641638673083 1.08938604562817 0.00258107261776762 miRanda -0.479244868905427 4.56216629494526e-10 NA NA NA hsa-miR-126-5p PIK3CA -0.953529188793816 7.91719143295591e-16 0.474083948253385 0.000138354293457267 mirMAP -0.0988715750932376 0.0279630254444252 NA NA NA hsa-miR-142-5p PIK3CA 0.288897753038094 0.0900009317815725 0.474083948253385 0.000138354293457267 mirMAP -0.094626445775446 0.00308255346715206 NA NA NA hsa-miR-146a-5p PIK3CA -0.0201236699646614 0.905882759106561 0.474083948253385 0.000138354293457267 mirMAP -0.0826746781762763 0.00998304675274026 NA NA NA hsa-miR-146b-5p PIK3CA 0.917975986853978 3.33749259316025e-09 0.474083948253385 0.000138354293457267 mirMAP -0.148623698754488 1.59224953432472e-05 NA NA NA hsa-miR-17-5p PIK3CA 1.41924888736771 2.75805544953758e-18 0.474083948253385 0.000138354293457267 miRNAWalker2_validate -0.121128691188414 0.000174670602072176 NA NA NA hsa-miR-186-5p PIK3CA 0.353452958261612 0.000145058448579496 0.474083948253385 0.000138354293457267 mirMAP -0.297473635549502 3.47602075640407e-07 NA NA NA hsa-miR-195-3p PIK3CA -0.624259620429699 0.000164279659144497 0.474083948253385 0.000138354293457267 mirMAP -0.0765321632457583 0.0201796264639037 NA NA NA hsa-miR-29b-1-5p PIK3CA 1.39669186711325 4.36960953138935e-11 0.474083948253385 0.000138354293457267 mirMAP -0.137606426566373 3.59722935161776e-08 NA NA NA hsa-miR-320a PIK3CA 0.801356001806321 4.91397101474502e-09 0.474083948253385 0.000138354293457267 miRanda -0.175899873415021 6.70887782534591e-06 NA NA NA hsa-miR-339-5p PIK3CA 1.07771430326938 2.45772601859307e-09 0.474083948253385 0.000138354293457267 miRanda -0.140087795917754 2.01352800438963e-06 NA NA NA hsa-miR-3607-3p PIK3CA 1.01377165357363 9.13355519701165e-05 0.474083948253385 0.000138354293457267 mirMAP -0.0822169096339811 7.75818029581085e-05 NA NA NA hsa-miR-374a-5p PIK3CA -0.621903385111545 6.61791773205282e-12 0.474083948253385 0.000138354293457267 mirMAP -0.120611005677499 0.0432936565606237 NA NA NA hsa-miR-374b-5p PIK3CA -0.288413933608091 0.0041474558664058 0.474083948253385 0.000138354293457267 mirMAP -0.251699909641235 3.33151190183606e-06 NA NA NA hsa-miR-495-3p PIK3CA -1.47803501311999 6.88839745293927e-13 0.474083948253385 0.000138354293457267 mirMAP -0.0866916875275685 0.000809885787828467 NA NA NA hsa-miR-501-5p PIK3CA 1.02806906860218 1.63456814370548e-09 0.474083948253385 0.000138354293457267 mirMAP -0.119863788285527 0.00016396438241956 NA NA NA hsa-miR-576-5p PIK3CA 0.940432050128373 6.90227595663302e-12 0.474083948253385 0.000138354293457267 PITA -0.211172584428942 4.54724446596707e-08 NA NA NA hsa-miR-582-3p PIK3CA -0.248056267546012 0.143798829508405 0.474083948253385 0.000138354293457267 miRNATAP -0.112384075179319 0.000457171976884077 NA NA NA hsa-miR-590-3p PIK3CA 0.221436901462551 0.0965904764063157 0.474083948253385 0.000138354293457267 miRanda;mirMAP -0.123785866799948 0.00253231685417896 NA NA NA hsa-miR-590-5p PIK3CA 0.763025362395968 3.65305892505623e-09 0.474083948253385 0.000138354293457267 miRanda -0.137459565446424 0.000946581823458912 NA NA NA hsa-miR-130a-3p PIK3CB 0.67051191119964 4.89747518735144e-06 -0.0830016803916331 0.377605728994098 miRNATAP -0.116910694940516 2.17993945184649e-05 NA NA NA hsa-miR-199b-3p PIK3CB -0.445649335808506 0.00178451574983478 -0.0830016803916331 0.377605728994098 miRNATAP -0.0939643163123392 0.00101214697601036 NA NA NA hsa-miR-19a-3p PIK3CB 1.35800152353624 2.80940447111944e-12 -0.0830016803916331 0.377605728994098 miRNATAP -0.0798765717473855 9.71980918879466e-05 NA NA NA hsa-miR-19b-3p PIK3CB 0.538732279378089 0.000622008277870679 -0.0830016803916331 0.377605728994098 miRNATAP -0.0995149069624077 0.000114558331759922 NA NA NA hsa-miR-214-3p PIK3CB -0.118240959890965 0.564962359782563 -0.0830016803916331 0.377605728994098 miRNATAP -0.0594411981378315 0.00286113763534796 NA NA NA hsa-miR-29b-3p PIK3CB -0.110721443686039 0.511264554091106 -0.0830016803916331 0.377605728994098 miRNATAP -0.0540346100937465 0.0263294716914819 NA NA NA hsa-miR-362-5p PIK3CB 0.41089772861323 0.0404254902071382 -0.0830016803916331 0.377605728994098 TargetScan -0.0755355544752343 0.000198439296897887 NA NA NA hsa-miR-454-3p PIK3CB 1.54137391927201 4.15861570449376e-20 -0.0830016803916331 0.377605728994098 miRNATAP -0.0940623968188241 5.64554307659511e-05 NA NA NA hsa-miR-455-5p PIK3CB 1.408595672323 5.52039116456697e-22 -0.0830016803916331 0.377605728994098 miRNATAP -0.112305249746916 2.65965267643942e-05 NA NA NA hsa-miR-1468-5p PIK3CD -1.11814152104975 9.8203170781489e-10 1.09936669850841 6.53933580961931e-14 MirTarget -0.190058878065479 5.39186071979921e-08 NA NA NA hsa-miR-199a-5p PIK3CD -0.364835768178638 0.0435119211101981 1.09936669850841 6.53933580961931e-14 MirTarget;PITA;miRanda;miRNATAP -0.10392905863127 0.00413232021656056 NA NA NA hsa-miR-199b-5p PIK3CD -1.08432682485992 7.68241801134089e-10 1.09936669850841 6.53933580961931e-14 MirTarget;PITA;miRanda;miRNATAP -0.174865940346935 1.46520648745166e-06 NA NA NA hsa-miR-29c-3p PIK3CD -2.08166260448948 8.3238369390898e-24 1.09936669850841 6.53933580961931e-14 mirMAP -0.123728555182124 3.91761687692399e-05 NA NA NA hsa-miR-30a-5p PIK3CD -1.79779915425811 1.93360169837799e-26 1.09936669850841 6.53933580961931e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.215181764255274 3.32715363881856e-09 23486085 miR 30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma; A luciferase reporter assay was performed to determine target association between miR-30a and phosphoinositide 3-kinase catalytic subunit delta PIK3CD miR-30a was significantly downregulated in highly metastatic CRC cell lines and metastatic tissues; Further studies revealed that PIK3CD is a direct target of miR-30a as miR-30a bounds directly to the 3'-UTR of PIK3CD subsequently reducing its expression; Similar to the restoring miR-30a expression PIK3CD downregulation inhibited cell migration and invasion whereas PIK3CD overexpression rescued the suppressive effect of miR-30a; Moreover significant downregulation of miR-30a in metastatic CRC tissues was found to be inversely correlated with PIK3CD expression; Mechanistic studies revealed that miR-30a down-regulated the expression of key components of the Akt/mTOR pathway whereas PIK3CD overexpression reversed this negative effect cell migration colorectal cancer hsa-miR-30b-3p PIK3CD -0.338530747940815 0.0223424741180399 1.09936669850841 6.53933580961931e-14 MirTarget -0.212653512510377 1.36776424072036e-06 NA NA NA hsa-miR-30b-5p PIK3CD -0.400238605368173 0.00346540992719245 1.09936669850841 6.53933580961931e-14 MirTarget -0.248889126985861 1.5426059915817e-07 NA NA NA hsa-miR-30c-5p PIK3CD 0.021222006155897 0.886366656528128 1.09936669850841 6.53933580961931e-14 MirTarget;miRNATAP -0.0991640132795503 0.0253179692166858 NA NA NA hsa-miR-30d-5p PIK3CD -0.38399848121878 0.000171129616944749 1.09936669850841 6.53933580961931e-14 MirTarget;miRNATAP -0.328266173808776 2.63776877258142e-07 NA NA NA hsa-miR-30e-5p PIK3CD -1.02114836019762 6.81961221797866e-17 1.09936669850841 6.53933580961931e-14 MirTarget -0.209324939899388 5.5934958220938e-05 NA NA NA hsa-miR-126-3p PIK3CG 0.0487843863772834 0.730130847436008 0.00752271010659966 0.976960758681749 miRTarBase -0.269414114814437 0.000806379873030215 NA NA NA hsa-miR-26b-5p PIK3CG -0.254478038884324 0.0285227763044636 0.00752271010659966 0.976960758681749 miRNAWalker2_validate -0.345718989912845 0.00041292580999725 NA NA NA hsa-miR-335-3p PIK3CG 0.336785882180547 0.0542446207938138 0.00752271010659966 0.976960758681749 mirMAP -0.20863783184887 0.00127495716846541 NA NA NA hsa-miR-3607-3p PIK3CG 1.01377165357363 9.13355519701165e-05 0.00752271010659966 0.976960758681749 mirMAP -0.153979618634459 0.000387199003031277 NA NA NA hsa-miR-542-3p PIK3CG 0.643308814904977 8.81635403230104e-07 0.00752271010659966 0.976960758681749 miRanda -0.171827060232144 0.0464828726352072 NA NA NA hsa-miR-103a-3p PIK3R1 0.556219385347418 1.55815736455067e-09 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.399035342845615 3.61390305129075e-07 NA NA NA hsa-miR-106b-5p PIK3R1 0.50378717276868 1.45412404526866e-05 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.140963509517229 0.0251914858781794 NA NA NA hsa-miR-1301-3p PIK3R1 2.13677668481885 6.11093268540831e-44 -1.21900359295309 1.01203266762174e-13 MirTarget -0.223004793710498 2.5912949051374e-07 NA NA NA hsa-miR-15a-5p PIK3R1 0.783550182002274 2.60699595655907e-11 -1.21900359295309 1.01203266762174e-13 MirTarget -0.385662977903284 1.7816116353762e-10 NA NA NA hsa-miR-15b-5p PIK3R1 0.85315666454713 3.79816274836297e-12 -1.21900359295309 1.01203266762174e-13 MirTarget -0.228618884263194 9.01523017331239e-05 NA NA NA hsa-miR-16-2-3p PIK3R1 1.1567130855258 1.01867256952189e-14 -1.21900359295309 1.01203266762174e-13 MirTarget -0.316425483424084 1.52783996282521e-11 NA NA NA hsa-miR-16-5p PIK3R1 0.521122945828175 1.40561786410572e-06 -1.21900359295309 1.01203266762174e-13 MirTarget -0.137571780323761 0.0422211194019347 NA NA NA hsa-miR-17-5p PIK3R1 1.41924888736771 2.75805544953758e-18 -1.21900359295309 1.01203266762174e-13 MirTarget;TargetScan;miRNATAP -0.463182517340129 2.13936557580788e-29 NA NA NA hsa-miR-182-5p PIK3R1 1.15060905311096 6.25565852529946e-10 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.244940881967473 1.25505363832818e-10 NA NA NA hsa-miR-185-5p PIK3R1 0.675225177054909 1.84953949190805e-13 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.284475955115523 0.000292942961891748 NA NA NA hsa-miR-186-5p PIK3R1 0.353452958261612 0.000145058448579496 -1.21900359295309 1.01203266762174e-13 mirMAP -0.319700116089251 4.98623038012755e-05 NA NA NA hsa-miR-188-5p PIK3R1 0.559328953885106 0.000430338888594543 -1.21900359295309 1.01203266762174e-13 MirTarget -0.160342440576419 0.000495444736297818 NA NA NA hsa-miR-200b-3p PIK3R1 0.0717138787925347 0.682858087587209 -1.21900359295309 1.01203266762174e-13 mirMAP -0.132316541375546 0.00152319590606084 NA NA NA hsa-miR-200c-3p PIK3R1 0.630251054099546 0.000131975031451555 -1.21900359295309 1.01203266762174e-13 mirMAP -0.165950070298812 0.000166005249225027 NA NA NA hsa-miR-20a-5p PIK3R1 1.1531986665452 1.02385132917958e-11 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.414035689070749 1.37700726304578e-24 NA NA NA hsa-miR-21-5p PIK3R1 1.62465922021121 3.44191300985109e-58 -1.21900359295309 1.01203266762174e-13 miRNAWalker2_validate;MirTarget;miRNATAP -0.347959293536401 6.14239978504788e-08 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 0.706731861922839 3.44318705980007e-07 -1.21900359295309 1.01203266762174e-13 mirMAP -0.186341013334501 0.000362689778770643 NA NA NA hsa-miR-221-3p PIK3R1 0.410625614724387 0.000741090075261272 -1.21900359295309 1.01203266762174e-13 MirTarget -0.152851847812038 0.0111778272930345 NA NA NA hsa-miR-222-3p PIK3R1 1.08197052578759 2.32604040301699e-14 -1.21900359295309 1.01203266762174e-13 MirTarget -0.324361920211689 6.16230355082933e-11 NA NA NA hsa-miR-224-3p PIK3R1 0.502645536188015 0.0081142387260641 -1.21900359295309 1.01203266762174e-13 mirMAP -0.120566945623901 0.00184832047796862 NA NA NA hsa-miR-29b-3p PIK3R1 -0.110721443686039 0.511264554091106 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.121645516169564 0.00518596779631768 NA NA NA hsa-miR-320a PIK3R1 0.801356001806321 4.91397101474502e-09 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.225199809648846 1.82460995490226e-05 NA NA NA hsa-miR-320b PIK3R1 1.23473838180754 3.04337566045537e-14 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.134920857869101 0.00211752860446172 NA NA NA hsa-miR-324-3p PIK3R1 0.867391246413545 3.63808540490361e-10 -1.21900359295309 1.01203266762174e-13 MirTarget;PITA;miRNATAP -0.177541714088148 0.000648957139596168 NA NA NA hsa-miR-3607-3p PIK3R1 1.01377165357363 9.13355519701165e-05 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.0702656865478126 0.0123603600878561 NA NA NA hsa-miR-424-5p PIK3R1 1.48125289532143 9.10372985713165e-19 -1.21900359295309 1.01203266762174e-13 MirTarget -0.194732317900543 3.45343462326547e-06 NA NA NA hsa-miR-429 PIK3R1 0.559451508722375 0.00563641638673083 -1.21900359295309 1.01203266762174e-13 mirMAP;miRNATAP -0.216477715044302 1.22729945836841e-09 NA NA NA hsa-miR-450b-5p PIK3R1 1.25529820885833 1.18847120528666e-15 -1.21900359295309 1.01203266762174e-13 miRNATAP -0.182288230735551 5.59609717066614e-05 NA NA NA hsa-miR-455-3p PIK3R1 2.68574446868387 4.28975903022818e-42 -1.21900359295309 1.01203266762174e-13 MirTarget;PITA;miRNATAP -0.231037194203872 4.67534308068801e-12 NA NA NA hsa-miR-532-3p PIK3R1 0.80240056676907 1.08989551712617e-09 -1.21900359295309 1.01203266762174e-13 MirTarget -0.131427614222316 0.0168100297097059 NA NA NA hsa-miR-584-5p PIK3R1 0.458655788667031 0.0421764547676754 -1.21900359295309 1.01203266762174e-13 mirMAP -0.158511510137748 8.00515680759562e-07 NA NA NA hsa-miR-589-3p PIK3R1 1.59559692667315 6.2886410639161e-15 -1.21900359295309 1.01203266762174e-13 mirMAP -0.276889190811914 4.76785574986701e-15 NA NA NA hsa-miR-590-3p PIK3R1 0.221436901462551 0.0965904764063157 -1.21900359295309 1.01203266762174e-13 miRanda;mirMAP -0.158050349961081 0.00414021352655968 NA NA NA hsa-miR-590-5p PIK3R1 0.763025362395968 3.65305892505623e-09 -1.21900359295309 1.01203266762174e-13 MirTarget;PITA;miRanda;miRNATAP -0.424270969807281 7.70480985025408e-15 NA NA NA hsa-miR-629-3p PIK3R1 1.43262037314105 2.37092217984413e-19 -1.21900359295309 1.01203266762174e-13 MirTarget -0.192452582760208 1.31715256298262e-05 NA NA NA hsa-miR-93-5p PIK3R1 1.61042951896619 5.1280369606967e-24 -1.21900359295309 1.01203266762174e-13 MirTarget;miRNATAP -0.348791344759735 3.1302460531533e-16 NA NA NA hsa-miR-96-5p PIK3R1 1.42326703011157 4.39736150032373e-14 -1.21900359295309 1.01203266762174e-13 TargetScan;miRNATAP -0.310953673912161 2.47412618125618e-17 NA NA NA hsa-miR-30a-5p PIK3R2 -1.79779915425811 1.93360169837799e-26 0.0764246627713367 0.352134366195245 miRNATAP -0.0804852123638666 5.55795139423746e-05 NA NA NA hsa-miR-181b-5p PIK3R3 0.974255518824355 2.64876280203475e-16 -0.129019532966171 0.451055967559973 MirTarget;miRNATAP -0.137195284242815 0.0248910467485379 NA NA NA hsa-miR-18a-3p PIK3R3 1.82583720936229 7.51297960972179e-19 -0.129019532966171 0.451055967559973 miRNAWalker2_validate -0.103240638013552 0.00398585116122596 NA NA NA hsa-miR-19a-3p PIK3R3 1.35800152353624 2.80940447111944e-12 -0.129019532966171 0.451055967559973 MirTarget;miRNATAP -0.153374017381767 4.01568767526052e-05 NA NA NA hsa-miR-19b-3p PIK3R3 0.538732279378089 0.000622008277870679 -0.129019532966171 0.451055967559973 MirTarget;miRNATAP -0.12996294371586 0.00591308278368021 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.39669186711325 4.36960953138935e-11 -0.129019532966171 0.451055967559973 mirMAP -0.137442753028623 6.48468495867568e-05 NA NA NA hsa-miR-323a-3p PIK3R3 0.554923914792824 0.00856909375866133 -0.129019532966171 0.451055967559973 mirMAP -0.0831144694365825 0.0206817746884839 NA NA NA hsa-miR-365a-3p PIK3R3 0.446833934952926 0.00233857759218299 -0.129019532966171 0.451055967559973 MirTarget -0.431569400997508 1.46400297130903e-18 NA NA NA hsa-miR-369-3p PIK3R3 -1.2344419076994 2.66882944171146e-10 -0.129019532966171 0.451055967559973 PITA -0.105890967034452 0.00482950119317686 NA NA NA hsa-miR-589-3p PIK3R3 1.59559692667315 6.2886410639161e-15 -0.129019532966171 0.451055967559973 mirMAP -0.138465461387875 0.000168219132587265 NA NA NA hsa-miR-624-5p PIK3R3 -0.229389464626096 0.110488966509615 -0.129019532966171 0.451055967559973 MirTarget -0.117735756807402 0.0241768558200248 NA NA NA hsa-miR-182-5p PIK3R5 1.15060905311096 6.25565852529946e-10 0.15902332125267 0.38685549407615 MirTarget -0.236115638976413 1.63099014479463e-08 NA NA NA hsa-miR-18a-3p PIK3R5 1.82583720936229 7.51297960972179e-19 0.15902332125267 0.38685549407615 MirTarget -0.160296162742907 2.89078394864452e-05 NA NA NA hsa-miR-944 PIK3R5 1.47323925060177 2.61626403984929e-13 0.15902332125267 0.38685549407615 mirMAP -0.211607874388069 3.42384043348289e-08 NA NA NA hsa-let-7g-5p PPP3CA -0.250780249469264 0.00939610188330072 0.0261166441094005 0.774380327390763 miRNATAP -0.129044274233211 0.00176768769369972 NA NA NA hsa-miR-106a-5p PPP3CA 0.67978010057847 0.00221925869726092 0.0261166441094005 0.774380327390763 miRNATAP -0.0824715932355796 2.81639366803291e-06 NA NA NA hsa-miR-106b-5p PPP3CA 0.50378717276868 1.45412404526866e-05 0.0261166441094005 0.774380327390763 miRNATAP -0.0899761361038284 0.00812386443299038 NA NA NA hsa-miR-142-3p PPP3CA 1.12754191614028 1.68798138028946e-08 0.0261166441094005 0.774380327390763 miRNATAP -0.0951315303293128 8.92858480391048e-07 NA NA NA hsa-miR-142-5p PPP3CA 0.288897753038094 0.0900009317815725 0.0261166441094005 0.774380327390763 PITA;mirMAP;miRNATAP -0.0787170470639805 0.000687363364366628 NA NA NA hsa-miR-17-3p PPP3CA -0.0127974722290336 0.909559935689875 0.0261166441094005 0.774380327390763 MirTarget -0.0845897935876711 0.0169436018525504 NA NA NA hsa-miR-17-5p PPP3CA 1.41924888736771 2.75805544953758e-18 0.0261166441094005 0.774380327390763 miRNATAP -0.107154786794133 4.49246161780872e-06 NA NA NA hsa-miR-186-5p PPP3CA 0.353452958261612 0.000145058448579496 0.0261166441094005 0.774380327390763 mirMAP -0.119442984122439 0.00521905941342711 NA NA NA hsa-miR-194-5p PPP3CA -0.0214221838459805 0.872940154118701 0.0261166441094005 0.774380327390763 MirTarget -0.227106380168213 4.11707254283389e-15 NA NA NA hsa-miR-20a-5p PPP3CA 1.1531986665452 1.02385132917958e-11 0.0261166441094005 0.774380327390763 miRNATAP -0.135937480891387 1.71175203332467e-09 NA NA NA hsa-miR-20b-5p PPP3CA 0.345967670847176 0.232014828043601 0.0261166441094005 0.774380327390763 miRNATAP -0.0810201561184221 1.83041997490799e-09 NA NA NA hsa-miR-30c-5p PPP3CA 0.021222006155897 0.886366656528128 0.0261166441094005 0.774380327390763 miRNATAP -0.138568670147619 1.67033051966156e-07 NA NA NA hsa-miR-30d-5p PPP3CA -0.38399848121878 0.000171129616944749 0.0261166441094005 0.774380327390763 miRNATAP -0.103928901064269 0.00747324777039719 NA NA NA hsa-miR-320a PPP3CA 0.801356001806321 4.91397101474502e-09 0.0261166441094005 0.774380327390763 miRanda -0.0816654090748999 0.00420740245691118 NA NA NA hsa-miR-335-3p PPP3CA 0.336785882180547 0.0542446207938138 0.0261166441094005 0.774380327390763 MirTarget -0.0843580346788209 0.000182553228777015 NA NA NA hsa-miR-33a-3p PPP3CA 0.20371038027126 0.212335697664505 0.0261166441094005 0.774380327390763 MirTarget;mirMAP;miRNATAP -0.0750952475347327 0.00227035901608472 NA NA NA hsa-miR-340-5p PPP3CA -0.608415693437977 4.44345153563513e-05 0.0261166441094005 0.774380327390763 mirMAP -0.055245784216522 0.0368850028693182 NA NA NA hsa-miR-3607-3p PPP3CA 1.01377165357363 9.13355519701165e-05 0.0261166441094005 0.774380327390763 MirTarget;mirMAP;miRNATAP -0.0704046022077566 2.95649744005633e-06 NA NA NA hsa-miR-361-3p PPP3CA 0.272298288982435 0.0147874880476998 0.0261166441094005 0.774380327390763 MirTarget;PITA;miRNATAP -0.147461540913571 3.1572107642519e-05 NA NA NA hsa-miR-501-3p PPP3CA 0.820141346319976 1.74562930463389e-08 0.0261166441094005 0.774380327390763 MirTarget;PITA;miRNATAP -0.0826446736475588 0.00210686162081216 NA NA NA hsa-miR-582-5p PPP3CA -0.0366995972742474 0.821827119138923 0.0261166441094005 0.774380327390763 miRNATAP -0.0685371481049165 0.00485027459879182 NA NA NA hsa-miR-590-3p PPP3CA 0.221436901462551 0.0965904764063157 0.0261166441094005 0.774380327390763 miRanda;mirMAP -0.1292662240092 1.28492091373993e-05 NA NA NA hsa-miR-590-5p PPP3CA 0.763025362395968 3.65305892505623e-09 0.0261166441094005 0.774380327390763 PITA;miRanda;miRNATAP -0.130608084993601 1.4121892378982e-05 NA NA NA hsa-miR-664a-3p PPP3CA -0.256108763664991 0.0513188660751664 0.0261166441094005 0.774380327390763 mirMAP -0.154862721187903 2.28408619679922e-07 NA NA NA hsa-miR-7-1-3p PPP3CA 1.13646121619622 1.49823237535933e-14 0.0261166441094005 0.774380327390763 MirTarget;mirMAP -0.113744929124115 1.18665245144482e-05 NA NA NA hsa-miR-93-3p PPP3CA 1.69225547123293 1.50964095575087e-25 0.0261166441094005 0.774380327390763 miRNATAP -0.0881159361923587 0.000144358044241312 NA NA NA hsa-miR-93-5p PPP3CA 1.61042951896619 5.1280369606967e-24 0.0261166441094005 0.774380327390763 miRNATAP -0.134887598190219 8.69707313946358e-09 NA NA NA hsa-miR-96-5p PPP3CA 1.42326703011157 4.39736150032373e-14 0.0261166441094005 0.774380327390763 TargetScan -0.105360576077386 1.99204409171748e-07 NA NA NA hsa-miR-15a-5p PPP3CB 0.783550182002274 2.60699595655907e-11 -0.430650123435909 1.6653183674225e-09 miRNATAP -0.08537598460612 0.00121299029061708 NA NA NA hsa-miR-15b-5p PPP3CB 0.85315666454713 3.79816274836297e-12 -0.430650123435909 1.6653183674225e-09 miRNATAP -0.147896038786253 2.77153942258358e-09 NA NA NA hsa-miR-16-5p PPP3CB 0.521122945828175 1.40561786410572e-06 -0.430650123435909 1.6653183674225e-09 miRNATAP -0.058380309005146 0.0451015308316871 NA NA NA hsa-miR-20a-3p PPP3CB 1.34885093664027 2.07697464119202e-12 -0.430650123435909 1.6653183674225e-09 miRNATAP -0.066768633004053 2.92915231573502e-05 NA NA NA hsa-miR-320a PPP3CB 0.801356001806321 4.91397101474502e-09 -0.430650123435909 1.6653183674225e-09 miRanda -0.070842877614031 0.00180367518529508 NA NA NA hsa-miR-320b PPP3CB 1.23473838180754 3.04337566045537e-14 -0.430650123435909 1.6653183674225e-09 miRanda -0.0851567896539945 5.81817271027209e-06 NA NA NA hsa-miR-339-5p PPP3CB 1.07771430326938 2.45772601859307e-09 -0.430650123435909 1.6653183674225e-09 miRanda -0.0595868875985441 0.00050405037793083 NA NA NA hsa-miR-361-5p PPP3CB 0.0803683277369505 0.314043140368058 -0.430650123435909 1.6653183674225e-09 miRanda -0.146324240065503 0.000258725360624939 NA NA NA hsa-miR-421 PPP3CB 0.945488088619653 2.35762398527362e-09 -0.430650123435909 1.6653183674225e-09 miRanda -0.0709609950839791 0.000298272981375767 NA NA NA hsa-miR-429 PPP3CB 0.559451508722375 0.00563641638673083 -0.430650123435909 1.6653183674225e-09 miRanda -0.126839398598655 4.12587575752935e-17 NA NA NA hsa-miR-452-5p PPP3CB 0.373288744398455 0.0348485937209964 -0.430650123435909 1.6653183674225e-09 MirTarget;miRNATAP -0.055928169979234 0.00165642000004803 NA NA NA hsa-miR-7-1-3p PPP3CB 1.13646121619622 1.49823237535933e-14 -0.430650123435909 1.6653183674225e-09 mirMAP -0.085009823387808 4.00870017276671e-05 NA NA NA hsa-miR-139-5p PPP3R1 -1.46099200329485 7.85040381494472e-22 0.041580163023105 0.406876417869994 miRanda -0.0533800968406107 8.4800714834964e-05 NA NA NA hsa-miR-26b-5p PPP3R1 -0.254478038884324 0.0285227763044636 0.041580163023105 0.406876417869994 miRNAWalker2_validate;MirTarget;miRNATAP -0.0683801034747046 0.000241068625003397 NA NA NA hsa-miR-30a-5p PPP3R1 -1.79779915425811 1.93360169837799e-26 0.041580163023105 0.406876417869994 miRNAWalker2_validate;MirTarget;miRNATAP -0.0620241599562396 2.56509420510415e-07 NA NA NA hsa-miR-30b-5p PPP3R1 -0.400238605368173 0.00346540992719245 0.041580163023105 0.406876417869994 MirTarget -0.0582203431123159 0.000215187236833984 NA NA NA hsa-miR-342-3p PPP3R1 0.99756868977753 9.28499866272332e-10 0.041580163023105 0.406876417869994 MirTarget;miRanda;miRNATAP -0.0514591304555878 7.54226434884959e-05 NA NA NA hsa-miR-34a-5p PPP3R1 -0.117372471043915 0.364001947180738 0.041580163023105 0.406876417869994 miRNAWalker2_validate -0.0554527300826295 0.000936630870587186 NA NA NA hsa-miR-130b-5p PRKACA 1.77265255049999 1.43627774829684e-29 -0.368261025128827 1.48055567739749e-07 mirMAP;miRNATAP -0.0593368506170908 0.00132791537714356 NA NA NA hsa-miR-146b-5p PRKACA 0.917975986853978 3.33749259316025e-09 -0.368261025128827 1.48055567739749e-07 PITA -0.0618794443116911 0.00152806435124403 NA NA NA hsa-miR-15a-5p PRKACA 0.783550182002274 2.60699595655907e-11 -0.368261025128827 1.48055567739749e-07 miRNATAP -0.0889542111308737 0.000550658185864705 NA NA NA hsa-miR-365a-3p PRKACA 0.446833934952926 0.00233857759218299 -0.368261025128827 1.48055567739749e-07 miRNAWalker2_validate -0.0634028208375217 0.00243693851064776 NA NA NA hsa-miR-744-5p PRKACA 0.436098372735845 0.000850400989351181 -0.368261025128827 1.48055567739749e-07 miRNAWalker2_validate -0.0651160214336402 0.00563962464156817 NA NA NA hsa-miR-92a-1-5p PRKACA 1.41314158431819 2.67965667765933e-11 -0.368261025128827 1.48055567739749e-07 mirMAP -0.071662903135456 3.9360998631478e-07 NA NA NA hsa-miR-96-5p PRKACA 1.42326703011157 4.39736150032373e-14 -0.368261025128827 1.48055567739749e-07 TargetScan -0.0815519508464318 2.26446337216478e-07 NA NA NA hsa-let-7a-3p PRKACB 0.0966652362351867 0.423761916840503 -0.321098607006344 0.0228761424530327 MirTarget;mirMAP;miRNATAP -0.24351006648709 1.69808754515966e-06 NA NA NA hsa-let-7d-3p PRKACB 0.770676758773193 9.57945374997326e-13 -0.321098607006344 0.0228761424530327 MirTarget -0.261113668353957 2.78655698859518e-06 NA NA NA hsa-miR-141-3p PRKACB 0.730011517758706 0.000120338355004032 -0.321098607006344 0.0228761424530327 MirTarget;TargetScan;miRNATAP -0.267679710851304 1.06126331262823e-17 NA NA NA hsa-miR-16-2-3p PRKACB 1.1567130855258 1.01867256952189e-14 -0.321098607006344 0.0228761424530327 mirMAP -0.25465198696094 1.15210482297961e-10 NA NA NA hsa-miR-17-5p PRKACB 1.41924888736771 2.75805544953758e-18 -0.321098607006344 0.0228761424530327 TargetScan -0.320719783263986 1.04231465157064e-19 NA NA NA hsa-miR-182-5p PRKACB 1.15060905311096 6.25565852529946e-10 -0.321098607006344 0.0228761424530327 MirTarget;miRNATAP -0.192126378855167 2.14564015173888e-09 NA NA NA hsa-miR-183-5p PRKACB 1.4313129319945 6.25230916431996e-14 -0.321098607006344 0.0228761424530327 MirTarget -0.193043292756991 4.67956422537156e-10 NA NA NA hsa-miR-18a-5p PRKACB 1.65455873230328 3.76457892277775e-20 -0.321098607006344 0.0228761424530327 miRNATAP -0.281434127350525 9.68681768909003e-19 NA NA NA hsa-miR-193a-3p PRKACB 0.22120710726779 0.111827069464729 -0.321098607006344 0.0228761424530327 miRanda -0.120890648652317 0.00645270297281106 NA NA NA hsa-miR-194-3p PRKACB 0.735945243226384 8.65425299041628e-05 -0.321098607006344 0.0228761424530327 MirTarget -0.0705365001746104 0.0349279107567946 NA NA NA hsa-miR-19a-3p PRKACB 1.35800152353624 2.80940447111944e-12 -0.321098607006344 0.0228761424530327 MirTarget;miRNATAP -0.258968002486092 6.18986461469059e-18 NA NA NA hsa-miR-19b-3p PRKACB 0.538732279378089 0.000622008277870679 -0.321098607006344 0.0228761424530327 miRNAWalker2_validate;MirTarget;miRNATAP -0.335571469796732 5.37740203716601e-19 NA NA NA hsa-miR-200a-3p PRKACB 0.607140814457753 0.00289840524858752 -0.321098607006344 0.0228761424530327 MirTarget;miRNATAP -0.241062026533704 1.65937825863575e-16 NA NA NA hsa-miR-200b-3p PRKACB 0.0717138787925347 0.682858087587209 -0.321098607006344 0.0228761424530327 MirTarget;TargetScan -0.231640096513903 1.90730092010153e-11 NA NA NA hsa-miR-200c-3p PRKACB 0.630251054099546 0.000131975031451555 -0.321098607006344 0.0228761424530327 MirTarget;miRNATAP -0.209750443181332 1.11607954800956e-08 NA NA NA hsa-miR-30d-3p PRKACB -0.577371911152798 2.02950840095287e-06 -0.321098607006344 0.0228761424530327 mirMAP -0.229710131067783 4.74198208250703e-06 NA NA NA hsa-miR-339-5p PRKACB 1.07771430326938 2.45772601859307e-09 -0.321098607006344 0.0228761424530327 miRanda -0.226395664639244 6.08522673686748e-12 NA NA NA hsa-miR-34a-5p PRKACB -0.117372471043915 0.364001947180738 -0.321098607006344 0.0228761424530327 miRNATAP -0.188258649958631 7.8062126512609e-05 NA NA NA hsa-miR-362-3p PRKACB -0.697212068252854 2.61718493418184e-06 -0.321098607006344 0.0228761424530327 PITA;miRanda;miRNATAP -0.0867156856810286 0.0363111499653747 NA NA NA hsa-miR-362-5p PRKACB 0.41089772861323 0.0404254902071382 -0.321098607006344 0.0228761424530327 PITA -0.231677226283398 9.49014505345782e-15 NA NA NA hsa-miR-429 PRKACB 0.559451508722375 0.00563641638673083 -0.321098607006344 0.0228761424530327 MirTarget;PITA;miRanda;miRNATAP -0.24828232747711 3.61288238132463e-17 NA NA NA hsa-miR-532-5p PRKACB -0.021857649390892 0.830992272120134 -0.321098607006344 0.0228761424530327 PITA -0.227164270683247 0.000174154322184187 NA NA NA hsa-miR-582-5p PRKACB -0.0366995972742474 0.821827119138923 -0.321098607006344 0.0228761424530327 MirTarget;PITA;miRNATAP -0.096537492619052 0.0108204525409491 NA NA NA hsa-miR-590-5p PRKACB 0.763025362395968 3.65305892505623e-09 -0.321098607006344 0.0228761424530327 miRanda -0.305639629088135 3.88857071786905e-11 NA NA NA hsa-miR-7-1-3p PRKACB 1.13646121619622 1.49823237535933e-14 -0.321098607006344 0.0228761424530327 mirMAP -0.163214783006832 5.48095567644113e-05 NA NA NA hsa-miR-708-3p PRKACB 1.32647174389322 4.87465491977979e-16 -0.321098607006344 0.0228761424530327 mirMAP -0.239908721941593 2.49822385276827e-11 NA NA NA hsa-miR-93-5p PRKACB 1.61042951896619 5.1280369606967e-24 -0.321098607006344 0.0228761424530327 miRNAWalker2_validate -0.265261521642743 2.04882387197337e-13 NA NA NA hsa-miR-944 PRKACB 1.47323925060177 2.61626403984929e-13 -0.321098607006344 0.0228761424530327 MirTarget;mirMAP -0.138499316290303 2.90532544481091e-06 NA NA NA hsa-miR-96-5p PRKACB 1.42326703011157 4.39736150032373e-14 -0.321098607006344 0.0228761424530327 miRNATAP -0.258796730941182 5.34409541983872e-17 NA NA NA hsa-miR-1296-5p PRKAR1A 0.222558939893167 0.187044627254045 -0.389597412593066 4.82491100285338e-08 miRNAWalker2_validate -0.0639866739833639 0.000575394492015949 NA NA NA hsa-miR-141-3p PRKAR1A 0.730011517758706 0.000120338355004032 -0.389597412593066 4.82491100285338e-08 TargetScan -0.103090104810107 1.84045061235339e-10 NA NA NA hsa-miR-16-2-3p PRKAR1A 1.1567130855258 1.01867256952189e-14 -0.389597412593066 4.82491100285338e-08 mirMAP -0.147844119213002 1.50213769346947e-13 NA NA NA hsa-miR-16-5p PRKAR1A 0.521122945828175 1.40561786410572e-06 -0.389597412593066 4.82491100285338e-08 miRNAWalker2_validate -0.0957129784411018 0.000935731600186429 NA NA NA hsa-miR-182-5p PRKAR1A 1.15060905311096 6.25565852529946e-10 -0.389597412593066 4.82491100285338e-08 miRNATAP -0.107900480713838 3.56638302735302e-11 NA NA NA hsa-miR-186-5p PRKAR1A 0.353452958261612 0.000145058448579496 -0.389597412593066 4.82491100285338e-08 mirMAP -0.111916840410913 0.000948714682105877 NA NA NA hsa-miR-200b-3p PRKAR1A 0.0717138787925347 0.682858087587209 -0.389597412593066 4.82491100285338e-08 TargetScan -0.0538903570685699 0.00259485110653118 NA NA NA hsa-miR-25-3p PRKAR1A 0.76549796417801 3.32282098247097e-11 -0.389597412593066 4.82491100285338e-08 miRNAWalker2_validate -0.19210144318215 2.39609572328574e-13 NA NA NA hsa-miR-30b-5p PRKAR1A -0.400238605368173 0.00346540992719245 -0.389597412593066 4.82491100285338e-08 mirMAP -0.0945211873265548 3.4358748636011e-05 NA NA NA hsa-miR-30c-5p PRKAR1A 0.021222006155897 0.886366656528128 -0.389597412593066 4.82491100285338e-08 mirMAP -0.12630306544726 1.53521860300728e-09 NA NA NA hsa-miR-320a PRKAR1A 0.801356001806321 4.91397101474502e-09 -0.389597412593066 4.82491100285338e-08 miRanda -0.115778028161641 2.44069879953624e-07 NA NA NA hsa-miR-320b PRKAR1A 1.23473838180754 3.04337566045537e-14 -0.389597412593066 4.82491100285338e-08 miRanda -0.0621209952837853 0.000950577220996412 NA NA NA hsa-miR-342-3p PRKAR1A 0.99756868977753 9.28499866272332e-10 -0.389597412593066 4.82491100285338e-08 miRanda -0.116041738797423 5.22669960637498e-10 NA NA NA hsa-miR-429 PRKAR1A 0.559451508722375 0.00563641638673083 -0.389597412593066 4.82491100285338e-08 PITA;miRanda;miRNATAP -0.0801759537398704 1.70666790549772e-07 NA NA NA hsa-miR-590-3p PRKAR1A 0.221436901462551 0.0965904764063157 -0.389597412593066 4.82491100285338e-08 miRanda;mirMAP -0.0759854313877432 0.00127946594517445 NA NA NA hsa-miR-590-5p PRKAR1A 0.763025362395968 3.65305892505623e-09 -0.389597412593066 4.82491100285338e-08 miRanda -0.150613970701625 1.77176331197164e-10 NA NA NA hsa-miR-664a-3p PRKAR1A -0.256108763664991 0.0513188660751664 -0.389597412593066 4.82491100285338e-08 mirMAP -0.0969356647127713 4.81100262008821e-05 NA NA NA hsa-miR-944 PRKAR1A 1.47323925060177 2.61626403984929e-13 -0.389597412593066 4.82491100285338e-08 PITA;mirMAP -0.0612733606075177 5.13788451095041e-05 NA NA NA hsa-miR-96-5p PRKAR1A 1.42326703011157 4.39736150032373e-14 -0.389597412593066 4.82491100285338e-08 miRNAWalker2_validate;TargetScan;miRNATAP -0.119065590674952 5.71948938774855e-14 NA NA NA hsa-let-7a-3p PRKAR2A 0.0966652362351867 0.423761916840503 -1.25168983515233 1.27768824698379e-10 mirMAP -0.340425967592318 1.89742449735715e-06 NA NA NA hsa-miR-103a-3p PRKAR2A 0.556219385347418 1.55815736455067e-09 -1.25168983515233 1.27768824698379e-10 miRNAWalker2_validate -0.528811006459108 1.00121323942934e-08 NA NA NA hsa-miR-106a-5p PRKAR2A 0.67978010057847 0.00221925869726092 -1.25168983515233 1.27768824698379e-10 mirMAP -0.120276386759936 0.00188355812632647 NA NA NA hsa-miR-106b-5p PRKAR2A 0.50378717276868 1.45412404526866e-05 -1.25168983515233 1.27768824698379e-10 mirMAP -0.166943231794707 0.0247335650276516 NA NA NA hsa-miR-125a-5p PRKAR2A 0.215366061934933 0.119550904549401 -1.25168983515233 1.27768824698379e-10 miRanda -0.509751806741783 5.42172137627373e-17 NA NA NA hsa-miR-146b-5p PRKAR2A 0.917975986853978 3.33749259316025e-09 -1.25168983515233 1.27768824698379e-10 miRanda -0.323423592029129 2.42222846577189e-09 NA NA NA hsa-miR-155-5p PRKAR2A 0.533437622040649 0.00248671179205372 -1.25168983515233 1.27768824698379e-10 miRNAWalker2_validate -0.189259999040221 0.000102344592491054 NA NA NA hsa-miR-16-5p PRKAR2A 0.521122945828175 1.40561786410572e-06 -1.25168983515233 1.27768824698379e-10 miRNAWalker2_validate -0.232890839616367 0.00351254008518136 NA NA NA hsa-miR-17-5p PRKAR2A 1.41924888736771 2.75805544953758e-18 -1.25168983515233 1.27768824698379e-10 mirMAP -0.422968588753284 2.08197027773857e-17 NA NA NA hsa-miR-182-5p PRKAR2A 1.15060905311096 6.25565852529946e-10 -1.25168983515233 1.27768824698379e-10 mirMAP -0.260676788024272 7.61874125148914e-09 NA NA NA hsa-miR-197-3p PRKAR2A 0.878693269130833 3.84847526014135e-15 -1.25168983515233 1.27768824698379e-10 miRNAWalker2_validate -0.281798523034492 0.000187399686567738 NA NA NA hsa-miR-20a-5p PRKAR2A 1.1531986665452 1.02385132917958e-11 -1.25168983515233 1.27768824698379e-10 mirMAP -0.456397659391615 2.26861919989771e-21 NA NA NA hsa-miR-20b-5p PRKAR2A 0.345967670847176 0.232014828043601 -1.25168983515233 1.27768824698379e-10 mirMAP -0.110356754479848 0.000208724223530462 NA NA NA hsa-miR-21-5p PRKAR2A 1.62465922021121 3.44191300985109e-58 -1.25168983515233 1.27768824698379e-10 mirMAP -0.523899288744781 3.20052867286087e-12 NA NA NA hsa-miR-25-3p PRKAR2A 0.76549796417801 3.32282098247097e-11 -1.25168983515233 1.27768824698379e-10 mirMAP -0.454053244193185 4.38299451998134e-10 NA NA NA hsa-miR-26b-5p PRKAR2A -0.254478038884324 0.0285227763044636 -1.25168983515233 1.27768824698379e-10 mirMAP -0.363503510011988 9.54627385013964e-07 NA NA NA hsa-miR-29a-5p PRKAR2A 0.323252792625584 0.0370417231222825 -1.25168983515233 1.27768824698379e-10 mirMAP -0.346440445450733 2.92555022965015e-10 NA NA NA hsa-miR-320a PRKAR2A 0.801356001806321 4.91397101474502e-09 -1.25168983515233 1.27768824698379e-10 mirMAP -0.412220214459044 1.69940131679459e-11 NA NA NA hsa-miR-320b PRKAR2A 1.23473838180754 3.04337566045537e-14 -1.25168983515233 1.27768824698379e-10 mirMAP -0.172223925310203 0.000882803865967564 NA NA NA hsa-miR-342-5p PRKAR2A 0.862385578881784 1.60007936373305e-08 -1.25168983515233 1.27768824698379e-10 miRNATAP -0.225454275217668 5.21315348993419e-05 NA NA NA hsa-miR-3607-3p PRKAR2A 1.01377165357363 9.13355519701165e-05 -1.25168983515233 1.27768824698379e-10 mirMAP -0.198539231480855 1.2364325973038e-09 NA NA NA hsa-miR-3913-5p PRKAR2A 0.48532077857571 0.00112373589405304 -1.25168983515233 1.27768824698379e-10 mirMAP -0.135619304076097 0.0198535887352557 NA NA NA hsa-miR-582-5p PRKAR2A -0.0366995972742474 0.821827119138923 -1.25168983515233 1.27768824698379e-10 miRNATAP -0.190507902393328 0.000328224480662222 NA NA NA hsa-miR-590-5p PRKAR2A 0.763025362395968 3.65305892505623e-09 -1.25168983515233 1.27768824698379e-10 mirMAP -0.403771843490581 5.61750356670728e-10 NA NA NA hsa-miR-7-1-3p PRKAR2A 1.13646121619622 1.49823237535933e-14 -1.25168983515233 1.27768824698379e-10 mirMAP -0.26506824258904 2.9040736820763e-06 NA NA NA hsa-miR-708-3p PRKAR2A 1.32647174389322 4.87465491977979e-16 -1.25168983515233 1.27768824698379e-10 mirMAP -0.31842608974608 3.12897267192118e-10 NA NA NA hsa-miR-769-3p PRKAR2A 0.89886491506181 2.21711828717073e-08 -1.25168983515233 1.27768824698379e-10 miRNAWalker2_validate -0.314883976841959 2.59088753902106e-09 NA NA NA hsa-miR-92a-3p PRKAR2A 0.994679542307232 1.32587679156217e-16 -1.25168983515233 1.27768824698379e-10 mirMAP -0.444592447277598 1.10293268440019e-10 NA NA NA hsa-let-7a-3p PRKAR2B 0.0966652362351867 0.423761916840503 -1.21120929063865 1.60162841325302e-08 mirMAP -0.490985141172042 2.64461212242593e-10 NA NA NA hsa-let-7f-1-3p PRKAR2B 0.700374242293247 8.65000484720084e-08 -1.21120929063865 1.60162841325302e-08 mirMAP -0.161315556711507 0.024875495546313 NA NA NA hsa-miR-200c-3p PRKAR2B 0.630251054099546 0.000131975031451555 -1.21120929063865 1.60162841325302e-08 miRNATAP -0.170155319345197 0.00292558667935794 NA NA NA hsa-miR-429 PRKAR2B 0.559451508722375 0.00563641638673083 -1.21120929063865 1.60162841325302e-08 PITA;miRanda;miRNATAP -0.182971031482459 8.58090167898111e-05 NA NA NA hsa-miR-450b-5p PRKAR2B 1.25529820885833 1.18847120528666e-15 -1.21120929063865 1.60162841325302e-08 mirMAP;miRNATAP -0.22033104367528 0.000170827595653302 NA NA NA hsa-miR-452-5p PRKAR2B 0.373288744398455 0.0348485937209964 -1.21120929063865 1.60162841325302e-08 miRNATAP -0.251581929989178 2.23375486045653e-06 NA NA NA hsa-miR-92a-3p PRKAR2B 0.994679542307232 1.32587679156217e-16 -1.21120929063865 1.60162841325302e-08 miRNATAP -0.453367881695819 2.17159417855546e-09 NA NA NA hsa-miR-944 PRKAR2B 1.47323925060177 2.61626403984929e-13 -1.21120929063865 1.60162841325302e-08 mirMAP -0.389416609356938 1.86253130878266e-18 NA NA NA hsa-miR-139-5p PRKX -1.46099200329485 7.85040381494472e-22 -0.151603564440898 0.3779654538133 MirTarget -0.0993672425749741 0.0358176786031649 NA NA NA hsa-miR-181a-5p PRKX 0.819060835827404 1.38616688310277e-13 -0.151603564440898 0.3779654538133 mirMAP -0.207430719919465 0.00177099251431452 NA NA NA hsa-miR-181b-5p PRKX 0.974255518824355 2.64876280203475e-16 -0.151603564440898 0.3779654538133 mirMAP -0.395265525562346 5.7519252637977e-11 NA NA NA hsa-miR-409-3p PRKX -0.342347118512604 0.0538776384301546 -0.151603564440898 0.3779654538133 mirMAP -0.0965421187351347 0.0221912116841254 NA NA NA hsa-miR-432-5p PRKX -1.37745409934142 1.95995628572162e-09 -0.151603564440898 0.3779654538133 miRNATAP -0.0712795727758148 0.0267580614422168 NA NA NA hsa-miR-450b-5p PRKX 1.25529820885833 1.18847120528666e-15 -0.151603564440898 0.3779654538133 mirMAP -0.192275284682013 3.2143180494236e-05 NA NA NA hsa-miR-495-3p PRKX -1.47803501311999 6.88839745293927e-13 -0.151603564440898 0.3779654538133 MirTarget -0.0978018701167569 0.00606479574898229 NA NA NA hsa-miR-539-5p PRKX -0.15206998860136 0.492550733728996 -0.151603564440898 0.3779654538133 mirMAP -0.105402290296118 0.00200608976227561 NA NA NA hsa-miR-542-3p PRKX 0.643308814904977 8.81635403230104e-07 -0.151603564440898 0.3779654538133 mirMAP -0.325292565431366 6.95556775285496e-09 NA NA NA hsa-miR-101-5p RELA -1.429324744941 4.00032662184937e-18 0.0427844130929831 0.511167069149631 mirMAP -0.0960552410138428 4.16642172076116e-09 NA NA NA hsa-miR-28-5p RELA -0.026996999089909 0.733047113251652 0.0427844130929831 0.511167069149631 miRanda -0.158597396386128 1.09687495536614e-05 NA NA NA hsa-miR-30e-5p RELA -1.02114836019762 6.81961221797866e-17 0.0427844130929831 0.511167069149631 miRNAWalker2_validate -0.0880155332623777 8.20912445499085e-05 NA NA NA hsa-miR-362-3p RELA -0.697212068252854 2.61718493418184e-06 0.0427844130929831 0.511167069149631 miRanda -0.0958641335016908 3.27953488138494e-07 NA NA NA hsa-miR-769-5p RELA 0.0865819375213306 0.445395188017017 0.0427844130929831 0.511167069149631 miRNATAP -0.115778992525935 3.19828405030521e-06 NA NA NA hsa-miR-664a-3p RIPK1 -0.256108763664991 0.0513188660751664 -0.0624815448114262 0.35026107070763 MirTarget -0.0504373190409037 0.0227225698184403 NA NA NA hsa-miR-654-3p TNF -1.77960431554497 1.76486415439529e-14 0.374125718035588 0.15340997881818 miRNATAP -0.177736166803963 0.000196513342903579 NA NA NA hsa-miR-145-5p TNFRSF10A -0.46917511594055 0.000685297625493134 0.134151747453153 0.349659945320127 MirTarget -0.179073726992412 6.80103048689331e-05 NA NA NA hsa-miR-362-3p TNFRSF10A -0.697212068252854 2.61718493418184e-06 0.134151747453153 0.349659945320127 miRanda -0.0839957237941083 0.0456631437832368 NA NA NA hsa-miR-26a-5p TNFRSF10B -1.09269574587169 1.24020612216319e-22 0.899245000221647 4.39740185337371e-13 mirMAP -0.169634213008881 0.000371413847003937 NA NA NA hsa-miR-30a-5p TNFRSF10B -1.79779915425811 1.93360169837799e-26 0.899245000221647 4.39740185337371e-13 miRNAWalker2_validate -0.100563840293477 0.00121972811884754 NA NA NA hsa-miR-30c-2-3p TNFRSF10B -1.82791447399693 2.41509888037865e-21 0.899245000221647 4.39740185337371e-13 MirTarget -0.0831718171537 0.0025344520568473 NA NA NA hsa-miR-340-5p TNFRSF10B -0.608415693437977 4.44345153563513e-05 0.899245000221647 4.39740185337371e-13 miRNAWalker2_validate -0.0905966127868301 0.014378371159782 NA NA NA hsa-miR-139-5p TNFRSF10D -1.46099200329485 7.85040381494472e-22 0.395680265921612 0.0575977960467274 miRanda -0.160461641944644 0.00516132752354956 NA NA NA hsa-miR-146b-5p TNFRSF10D 0.917975986853978 3.33749259316025e-09 0.395680265921612 0.0575977960467274 mirMAP -0.13647866932294 0.0182598573099929 NA NA NA hsa-miR-26a-5p TNFRSF10D -1.09269574587169 1.24020612216319e-22 0.395680265921612 0.0575977960467274 mirMAP -0.289375808934209 0.000215584705277274 NA NA NA hsa-miR-142-3p TNFRSF1A 1.12754191614028 1.68798138028946e-08 0.138960408487216 0.0940089243204643 miRanda -0.0680571378203328 0.000122866911903119 NA NA NA hsa-miR-29a-3p TNFRSF1A -1.26881270980079 2.82496991513463e-22 0.138960408487216 0.0940089243204643 MirTarget;miRNATAP -0.0864311350980356 0.0010962519704778 NA NA NA hsa-miR-29b-3p TNFRSF1A -0.110721443686039 0.511264554091106 0.138960408487216 0.0940089243204643 MirTarget;miRNATAP -0.094289038372346 9.64356467795827e-06 NA NA NA hsa-miR-29c-3p TNFRSF1A -2.08166260448948 8.3238369390898e-24 0.138960408487216 0.0940089243204643 MirTarget;miRNATAP -0.134980179214262 6.15978518109614e-17 NA NA NA hsa-miR-590-3p TNFRSF1A 0.221436901462551 0.0965904764063157 0.138960408487216 0.0940089243204643 miRanda -0.0976452478099843 0.000311141107329333 NA NA NA hsa-miR-766-3p TNFRSF1A 1.07002176594541 8.2375790648059e-16 0.138960408487216 0.0940089243204643 MirTarget -0.0660264320340665 0.012547089782936 NA NA NA hsa-miR-129-5p TNFSF10 -0.246329588499478 0.436451191224681 0.698343273440786 0.000118028838768454 miRanda -0.135332005849678 8.16612582312609e-08 NA NA NA hsa-miR-217 TNFSF10 -1.35391381055929 2.42394951427902e-09 0.698343273440786 0.000118028838768454 miRanda -0.0970557676992148 0.00485309205805829 NA NA NA hsa-miR-33a-3p TNFSF10 0.20371038027126 0.212335697664505 0.698343273440786 0.000118028838768454 mirMAP -0.161023896440522 0.00112179862352293 NA NA NA hsa-miR-361-5p TNFSF10 0.0803683277369505 0.314043140368058 0.698343273440786 0.000118028838768454 miRanda -0.658401630661612 3.95899072791368e-11 NA NA NA hsa-miR-429 TNFSF10 0.559451508722375 0.00563641638673083 0.698343273440786 0.000118028838768454 miRanda -0.0795905108317417 0.042858240604832 NA NA NA hsa-miR-98-5p TNFSF10 0.0176698653376732 0.858271091070735 0.698343273440786 0.000118028838768454 miRNAWalker2_validate -0.372143943336829 4.02164060229724e-06 NA NA NA hsa-miR-27a-3p TP53 0.348456440505425 0.00126682892514312 -0.41755807197951 0.03001853518726 miRNAWalker2_validate -0.202518579356515 0.009421402460679 NA NA NA hsa-miR-324-3p TRADD 0.867391246413545 3.63808540490361e-10 0.241224013193448 0.0171963807944101 miRNATAP -0.115481836212859 0.000228421451511298 NA NA NA hsa-miR-146b-5p XIAP 0.917975986853978 3.33749259316025e-09 -0.0135944666057846 0.864404764525446 mirMAP;miRNATAP -0.0904914248300491 3.42885945618074e-05 NA NA NA hsa-miR-155-5p XIAP 0.533437622040649 0.00248671179205372 -0.0135944666057846 0.864404764525446 MirTarget -0.0672681534345136 0.000557120249135754 26779627 Bioinformatic predictions the dual-luciferase reporter assay and western blot analysis were used to detect how miR-155 regulates X-linked inhibitor of apoptosis protein XIAP; Furthermore the results from the luciferase assays and western blot analysis identified XIAP as the direct target of miR-155; In addition introducing XIAP cDNA without a three prime untranslated region 3'-UTR rescued the miR-155 promotion of apoptosis; These results indicate that miR-155 mediates cisplatin-induced apoptosis by targeting XIAP in ovarian cancer cells and that miR-155 could be a potential therapeutic target to increase the efficiency of ovarian cancer interventions ovarian cancer hsa-miR-16-1-3p XIAP 0.955017760172879 5.95379292601146e-11 -0.0135944666057846 0.864404764525446 mirMAP -0.0594647957084624 0.0108062420524351 NA NA NA hsa-miR-16-2-3p XIAP 1.1567130855258 1.01867256952189e-14 -0.0135944666057846 0.864404764525446 mirMAP -0.0711169618975847 0.00157224238075233 NA NA NA hsa-miR-17-5p XIAP 1.41924888736771 2.75805544953758e-18 -0.0135944666057846 0.864404764525446 miRNAWalker2_validate;TargetScan -0.0963988315084937 2.22980709667602e-06 NA NA NA hsa-miR-181a-2-3p XIAP 0.562132917934234 4.79313448225408e-05 -0.0135944666057846 0.864404764525446 mirMAP -0.0669847102564157 0.00711297813971642 NA NA NA hsa-miR-181a-5p XIAP 0.819060835827404 1.38616688310277e-13 -0.0135944666057846 0.864404764525446 miRNAWalker2_validate;miRTarBase;mirMAP -0.105727456128166 0.000541621485187187 NA NA NA hsa-miR-181b-5p XIAP 0.974255518824355 2.64876280203475e-16 -0.0135944666057846 0.864404764525446 miRNAWalker2_validate;miRTarBase;mirMAP -0.0999403775844196 0.000399773625426178 NA NA NA hsa-miR-186-5p XIAP 0.353452958261612 0.000145058448579496 -0.0135944666057846 0.864404764525446 MirTarget;miRNATAP -0.0862153466488788 0.021035101595894 NA NA NA hsa-miR-19a-3p XIAP 1.35800152353624 2.80940447111944e-12 -0.0135944666057846 0.864404764525446 mirMAP -0.0894427760602669 2.04627820970545e-07 NA NA NA hsa-miR-19b-1-5p XIAP 0.757034032029085 2.99828133413343e-07 -0.0135944666057846 0.864404764525446 MirTarget -0.0848128310246287 0.000240148549784916 NA NA NA hsa-miR-19b-3p XIAP 0.538732279378089 0.000622008277870679 -0.0135944666057846 0.864404764525446 mirMAP -0.13494345252627 3.75698427158479e-10 NA NA NA hsa-miR-20a-5p XIAP 1.1531986665452 1.02385132917958e-11 -0.0135944666057846 0.864404764525446 miRNATAP -0.112141898497451 1.32864984836325e-08 NA NA NA hsa-miR-25-3p XIAP 0.76549796417801 3.32282098247097e-11 -0.0135944666057846 0.864404764525446 mirMAP -0.0996971706514127 0.000710562970787815 NA NA NA hsa-miR-26a-2-3p XIAP -0.444498687388748 0.00325793861409413 -0.0135944666057846 0.864404764525446 mirMAP -0.0721452156228062 0.0015794229582001 NA NA NA hsa-miR-29a-5p XIAP 0.323252792625584 0.0370417231222825 -0.0135944666057846 0.864404764525446 mirMAP -0.0944194418710011 2.07663824530741e-05 NA NA NA hsa-miR-320a XIAP 0.801356001806321 4.91397101474502e-09 -0.0135944666057846 0.864404764525446 MirTarget;miRanda;miRNATAP -0.107877733959585 1.3343853309143e-05 NA NA NA hsa-miR-3607-3p XIAP 1.01377165357363 9.13355519701165e-05 -0.0135944666057846 0.864404764525446 mirMAP -0.0507659531959557 0.000118842512588187 NA NA NA hsa-miR-500a-5p XIAP 0.675401699376111 8.24389004707854e-05 -0.0135944666057846 0.864404764525446 mirMAP;miRNATAP -0.103619877052801 1.74356177711505e-07 NA NA NA hsa-miR-664a-3p XIAP -0.256108763664991 0.0513188660751664 -0.0135944666057846 0.864404764525446 mirMAP -0.0561480364145522 0.0334240453114808 NA NA NA hsa-miR-708-3p XIAP 1.32647174389322 4.87465491977979e-16 -0.0135944666057846 0.864404764525446 mirMAP -0.059503079597842 0.00372789214882561 NA NA NA hsa-miR-92a-3p XIAP 0.994679542307232 1.32587679156217e-16 -0.0135944666057846 0.864404764525446 mirMAP -0.0949298072840502 0.000673717446227485 NA NA NA