miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-15a-5p	BCL2	0.812445324157528	4.50263417099822e-20	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.390139881240154	1.08000528360666e-09	25594541;22335947;26915294;18931683;25623762	MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells	;;poor survival;;drug resistance	breast cancer;breast cancer;lung cancer;prostate cancer;colon cancer
hsa-miR-15b-3p	BCL2	1.12898579025388	1.18050912917317e-14	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.310741788828047	6.78718604611496e-16	25594541;26915294;26884837;18449891	MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MiR 15b mediates liver cancer cells proliferation through targeting BCL 2; MiR-15b overexpression downregulated BCL2 mRNA and protein expression obviously P < 0.05; On the contrary miR-15b inhibitor transfection markedly reduced miR-15b expression in liver cancer cells P < 0.05 promoted tumor cell proliferation and increased BCL2 mRNA and protein expression; MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression;miR 15b and miR 16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells; The downregulation of miR-15b and miR-16 in SGC7901/VCR cells was concurrent with the upregulation of Bcl-2 protein; Taken together our findings suggest that miR-15b and miR-16 could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2	;poor survival;;drug resistance	breast cancer;lung cancer;liver cancer;gastric cancer
hsa-miR-17-5p	BCL2	0.599531757298529	1.07318660415906e-05	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.416922204785524	7.52642290968327e-24	25435430	Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2		lung cancer
hsa-miR-181a-5p	BCL2	0.635863607630183	6.72486918157744e-11	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.399174853804926	9.83051271483704e-12	24335172;24267199;23740615;25524579;27534652	The function role of miR 181a in chemosensitivity to adriamycin by targeting Bcl 2 in low invasive breast cancer cells; Luciferase reporter vector with the putative BCL-2 3' untranslated region 3'UTR was constructed to explore whether BCL-2 was a direct target gene of miR-181a; Real-time PCR was performed to test the expression of miR-181a and Bcl-2 in the selected breast cancer tissue samples; Transfected with miR-181a mimic in cells resulted in the decreased expression of Bcl-2; At least in part the detection of miR-181a may direct the clinical medication in patients with neoadjuvant chemotherapy because of miR-181a enhanced adriamycin-induced apoptosis via targeting Bcl-2;Bufalin was found to induce the expression of miR-181a a small non-coding RNA believed to induce apoptosis by repressing its target gene BCL-2; In prostate cancer PC-3cell line bufalin-induced apoptosis can be largely attenuated by a miR-181a inhibitor which blocked bufalin-induced Bcl-2 reduction and caspase-3 activation;The results from Western blotting indicated that miR-181a might be associated with the up-regulation of bcl-2 and matrix metalloproteinase 9 and the down-regulation of tissue inhibitor of metalloproteinases-3 and p21 in MG63 cells;Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression;In addition inhibition of miR-181a promoted apoptosis of HeLa and CaSKi cells due to increasing Bax expression and decreasing Bcl-2 expression	;;;;	breast cancer;prostate cancer;sarcoma;lung squamous cell cancer;cervical and endocervical cancer
hsa-miR-181b-5p	BCL2	1.22749257795094	1.21998198830919e-27	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.46875883187563	8.08303248718094e-22	25524579	Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression		lung squamous cell cancer
hsa-miR-186-5p	BCL2	-0.426987301460247	1.04129380549315e-05	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.348265462226792	5.09173882444383e-09		NA	NA	NA
hsa-miR-20a-5p	BCL2	0.44979911120222	0.000602386964327228	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.398529315160521	3.65662136244948e-20		NA	NA	NA
hsa-miR-21-5p	BCL2	2.32007501846389	3.08394781855554e-137	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.486116466611641	4.94993012898121e-21	26555418;21468550;25994220;25381586;23359184;22964582;21376256	The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells	;;;;;;drug resistance	breast cancer;bladder cancer;colorectal cancer;sarcoma;pancreatic cancer;lung cancer;pancreatic cancer
hsa-miR-24-2-5p	BCL2	-0.222445793556803	0.059573849265115	-0.895845361347303	1.04475176246219e-07	miRNAWalker2_validate;miRTarBase	-0.314657429269267	1.22690370959234e-10		NA	NA	NA
hsa-miR-374a-5p	BCL2	-0.239709888246804	0.00309819667153627	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.330216657607334	4.44639283995132e-06		NA	NA	NA
hsa-miR-455-5p	BCL2	0.284641224662773	0.0357572339594277	-0.895845361347303	1.04475176246219e-07	mirMAP	-0.409582744430861	1.37477678088678e-22		NA	NA	NA
hsa-miR-590-3p	BCL2	1.27438512890514	1.03164723481469e-23	-0.895845361347303	1.04475176246219e-07	miRanda;mirMAP	-0.386064412166968	3.36735476522038e-17		NA	NA	NA
hsa-miR-590-5p	BCL2	0.746515607868274	8.51300479640125e-09	-0.895845361347303	1.04475176246219e-07	miRanda	-0.432407489499855	2.16078449133157e-23		NA	NA	NA