miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-425-5p ADARB1 0.354606074344121 0.845979106734409 0.120453256624796 0.889183329658728 mirMAP -0.283065249825669 1.17017811580193e-10 NA NA NA hsa-miR-425-5p AFF2 0.354606074344121 0.845979106734409 -0.0995918386413326 0.896629105024407 miRNATAP -0.47392197530194 3.38057076566502e-05 NA NA NA hsa-miR-425-5p AMPH 0.354606074344121 0.845979106734409 -0.846340683731462 0.0564045722680839 MirTarget;miRNATAP -0.664813266623668 2.61846230003399e-12 NA NA NA hsa-miR-425-5p ANTXR1 0.354606074344121 0.845979106734409 -0.405220925607642 0.789750261639452 MirTarget -0.814242922004579 1.96051460642592e-17 NA NA NA hsa-miR-425-5p BCAT1 0.354606074344121 0.845979106734409 -0.278305479804511 0.727551294734187 MirTarget -0.610715760614027 4.16210490140772e-14 NA NA NA hsa-miR-425-5p BEX4 0.354606074344121 0.845979106734409 -0.654509012559659 0.335547603639687 miRNAWalker2_validate;MirTarget -0.401276736162793 7.22448280733229e-07 NA NA NA hsa-miR-425-5p C3orf70 0.354606074344121 0.845979106734409 0.158958333005885 0.835474082500918 miRNATAP -0.231616824805085 0.00676939237424626 NA NA NA hsa-miR-425-5p CACNA1E 0.354606074344121 0.845979106734409 0.0224970248470509 0.972637163029998 mirMAP -0.545425296608196 2.13370188447364e-05 NA NA NA hsa-miR-425-5p CBX6 0.354606074344121 0.845979106734409 0.225403964723264 0.782719533416742 miRNATAP -0.483243198735653 1.13385164414614e-08 NA NA NA hsa-miR-425-5p CFL2 0.354606074344121 0.845979106734409 -0.165638593614143 0.834125604099382 miRNATAP -0.481282676078036 4.27033086804076e-18 NA NA NA hsa-miR-425-5p CHL1 0.354606074344121 0.845979106734409 -0.0983417248342554 0.862180724309222 mirMAP -0.833105647245856 8.22340179663411e-11 NA NA NA hsa-miR-425-5p CLU 0.354606074344121 0.845979106734409 -0.024649138843488 0.984847562904143 miRNAWalker2_validate -0.639147400647713 3.67611891506296e-10 NA NA NA hsa-miR-425-5p CNTN2 0.354606074344121 0.845979106734409 -0.625132696918374 0.52356577310376 mirMAP -0.759981747422028 2.38283969660205e-09 NA NA NA hsa-miR-425-5p CYGB 0.354606074344121 0.845979106734409 -0.304757799385234 0.750924897780136 MirTarget -0.261177995487946 3.04969364735844e-06 NA NA NA hsa-miR-425-5p CYYR1 0.354606074344121 0.845979106734409 -0.248032671210642 0.68684605201635 MirTarget -0.420216545917722 3.90873828792554e-14 NA NA NA hsa-miR-425-5p DIP2C 0.354606074344121 0.845979106734409 0.0930807486854017 0.922762757461971 MirTarget;miRNATAP -0.37917308411408 2.11301445669096e-10 NA NA NA hsa-miR-425-5p DPYSL2 0.354606074344121 0.845979106734409 0.364639316331698 0.802840092502424 miRNAWalker2_validate -0.238027663357297 0.000443765743582536 NA NA NA hsa-miR-425-5p DTNA 0.354606074344121 0.845979106734409 -0.788233596271033 0.175921086049778 mirMAP -0.713598030497373 3.5610318780662e-08 NA NA NA hsa-miR-425-5p EDIL3 0.354606074344121 0.845979106734409 -0.212629115183296 0.772510282152206 MirTarget -0.68479893327319 7.90192256992065e-13 NA NA NA hsa-miR-425-5p ERC1 0.354606074344121 0.845979106734409 0.00624934946992095 0.996073420369816 mirMAP -0.117587949967327 0.000414689936303221 NA NA NA hsa-miR-425-5p FKBP1B 0.354606074344121 0.845979106734409 -0.417497109742601 0.339433269139877 miRNATAP -0.254982056813924 0.00967173771002244 NA NA NA hsa-miR-425-5p FOSL2 0.354606074344121 0.845979106734409 0.0702175061474515 0.961743879072078 mirMAP -0.183622186624599 3.2672771860644e-05 NA NA NA hsa-miR-425-5p FOXN3 0.354606074344121 0.845979106734409 -0.00130522112466913 0.999217816019789 miRNATAP -0.169130925743894 4.65555472337259e-05 NA NA NA hsa-miR-425-5p FST 0.354606074344121 0.845979106734409 -0.803012377757241 0.0716831550584628 MirTarget -0.80329186889095 3.83530048210964e-16 NA NA NA hsa-miR-425-5p GNB5 0.354606074344121 0.845979106734409 0.0649528135314386 0.938218455897555 miRNAWalker2_validate -0.286665566892633 4.13300378904745e-08 NA NA NA hsa-miR-425-5p GREB1 0.354606074344121 0.845979106734409 -0.344299733567788 0.326908512014006 MirTarget -0.42950878829228 1.14474209713716e-07 NA NA NA hsa-miR-425-5p HHIP 0.354606074344121 0.845979106734409 -0.559721650231381 0.331886542536477 mirMAP -0.484117162094881 0.000424713790716386 NA NA NA hsa-miR-425-5p HSPB8 0.354606074344121 0.845979106734409 -0.450905727566128 0.530818766759679 MirTarget -0.939771265258893 5.83199818731545e-23 NA NA NA hsa-miR-425-5p IGSF1 0.354606074344121 0.845979106734409 -1.13249696201536 0.174117665170389 miRNAWalker2_validate -0.314662277178524 0.0329864833622104 NA NA NA hsa-miR-425-5p IL18BP 0.354606074344121 0.845979106734409 0.241767464724244 0.785783618512655 MirTarget -0.305951599048773 8.18745603703155e-09 NA NA NA hsa-miR-425-5p ITGB3 0.354606074344121 0.845979106734409 -0.140072224496413 0.81966441288745 MirTarget -0.614251909704281 8.64762548208889e-16 NA NA NA hsa-miR-425-5p ITPR1 0.354606074344121 0.845979106734409 0.100701750459588 0.903939596742304 MirTarget;miRNATAP -0.457519160719506 2.94259705715632e-12 NA NA NA hsa-miR-425-5p KCTD15 0.354606074344121 0.845979106734409 0.185256763709838 0.833214470759545 mirMAP -0.387567439270147 3.05485707344251e-08 NA NA NA hsa-miR-425-5p KIAA0513 0.354606074344121 0.845979106734409 0.20110604161778 0.824931488458158 mirMAP -0.154921118292524 0.023988336308006 NA NA NA hsa-miR-425-5p KIAA1024 0.354606074344121 0.845979106734409 0.0163726988285201 0.955209512697285 mirMAP -0.161043553464867 0.012513844630518 NA NA NA hsa-miR-425-5p KIAA1614 0.354606074344121 0.845979106734409 -0.194747994411808 0.474995019838823 mirMAP -0.383845547443315 1.96271913461088e-10 NA NA NA hsa-miR-425-5p KIAA2022 0.354606074344121 0.845979106734409 -0.681486862146998 0.439640719575263 miRNATAP -1.00264106254625 8.83361680992817e-17 NA NA NA hsa-miR-425-5p KIF1A 0.354606074344121 0.845979106734409 -1.18110946220452 0.141838672507843 mirMAP -0.881785517608357 1.26123002971538e-08 NA NA NA hsa-miR-425-5p KLHL13 0.354606074344121 0.845979106734409 -0.0987522997793844 0.875732362909764 MirTarget;miRNATAP -0.32442563149167 0.0166036619451331 NA NA NA hsa-miR-425-5p LCOR 0.354606074344121 0.845979106734409 0.384340349642144 0.540630047402759 miRNAWalker2_validate -0.157307861830175 0.00346387677240356 NA NA NA hsa-miR-425-5p LDOC1L 0.354606074344121 0.845979106734409 0.332662035949408 0.788616141188517 MirTarget;mirMAP -0.119963529567006 0.00011367240174753 NA NA NA hsa-miR-425-5p LONRF2 0.354606074344121 0.845979106734409 -0.47629791169293 0.573631825721548 mirMAP -1.4072901628148 6.54291372148727e-21 NA NA NA hsa-miR-425-5p LRRC15 0.354606074344121 0.845979106734409 0.28276303578193 0.759925850447773 mirMAP -0.648864073972254 2.80971762951372e-08 NA NA NA hsa-miR-425-5p MAN1C1 0.354606074344121 0.845979106734409 0.0540928411746462 0.93057576102255 MirTarget -0.483580140883657 2.16310293023393e-09 NA NA NA hsa-miR-425-5p MBP 0.354606074344121 0.845979106734409 0.433284187623385 0.732449068768016 mirMAP -0.109319298538309 0.00606566414328779 NA NA NA hsa-miR-425-5p MEF2C 0.354606074344121 0.845979106734409 -0.174491220363078 0.828081225511472 MirTarget;miRNATAP -0.436462665567055 1.72670814809168e-11 NA NA NA hsa-miR-425-5p N4BP3 0.354606074344121 0.845979106734409 -0.332700798732332 0.555971337624476 mirMAP -0.341777948837558 3.53625891751783e-09 NA NA NA hsa-miR-425-5p NAT8L 0.354606074344121 0.845979106734409 -0.33953631720312 0.636370098764405 mirMAP -0.318615533805011 0.00592967881456327 NA NA NA hsa-miR-425-5p NCAM1 0.354606074344121 0.845979106734409 0.120146355426511 0.822713111149455 miRNATAP -0.529293258071001 1.72210165970266e-06 NA NA NA hsa-miR-425-5p NCF2 0.354606074344121 0.845979106734409 -0.00594635542383637 0.994372373487782 MirTarget -0.542082055669823 7.13813353706896e-09 NA NA NA hsa-miR-425-5p NECAB1 0.354606074344121 0.845979106734409 -0.53884318847982 0.186847734504168 MirTarget -0.722111380276361 1.36478978879315e-18 NA NA NA hsa-miR-425-5p NOS1 0.354606074344121 0.845979106734409 -1.29793384533053 0.242118228586062 mirMAP -1.01179092518329 2.65483648191115e-13 NA NA NA hsa-miR-425-5p NOVA2 0.354606074344121 0.845979106734409 -0.320563725927058 0.223669535711304 mirMAP -0.309523737676617 7.49315278417986e-08 NA NA NA hsa-miR-425-5p NRIP3 0.354606074344121 0.845979106734409 -0.53131240958095 0.0987666920419638 MirTarget -0.316258579797859 5.96582717699814e-06 NA NA NA hsa-miR-425-5p OSBPL8 0.354606074344121 0.845979106734409 0.00704238691995052 0.995753982956424 miRNATAP -0.111530496696219 0.000840191403016413 NA NA NA hsa-miR-425-5p PAFAH1B1 0.354606074344121 0.845979106734409 0.0598717654143206 0.969282800634038 MirTarget;miRNATAP -0.136459543430829 5.32419609829386e-08 NA NA NA hsa-miR-425-5p PCDHB5 0.354606074344121 0.845979106734409 -0.842955508864724 0.0366445773909145 MirTarget -0.647084779506458 6.48273344365465e-16 NA NA NA hsa-miR-425-5p PDE4A 0.354606074344121 0.845979106734409 0.0615575443795082 0.95567086395917 miRNATAP -0.128266819535689 0.0060002692179569 NA NA NA hsa-miR-425-5p PHF21A 0.354606074344121 0.845979106734409 -0.122222056904124 0.907550366794039 MirTarget -0.144692801650875 3.87567155871494e-08 NA NA NA hsa-miR-425-5p PIP4K2A 0.354606074344121 0.845979106734409 -0.13451286017661 0.898842206898117 miRNAWalker2_validate -0.210665651203123 3.34371243127712e-10 NA NA NA hsa-miR-425-5p PNMAL1 0.354606074344121 0.845979106734409 -0.923740104454518 0.0569083502690787 MirTarget -0.816024873556326 3.97052643513794e-13 NA NA NA hsa-miR-425-5p PPM1L 0.354606074344121 0.845979106734409 0.517828192122245 0.23211374331004 MirTarget -0.154175697833971 0.00629344498500602 NA NA NA hsa-miR-425-5p PSD3 0.354606074344121 0.845979106734409 0.344093696549416 0.750027821944281 mirMAP -0.18340273112285 0.00139352017659504 NA NA NA hsa-miR-425-5p PTCHD1 0.354606074344121 0.845979106734409 0.330469069069661 0.721880303430732 mirMAP -0.88887611555513 1.08820675891532e-09 NA NA NA hsa-miR-106a-5p PTEN 0.203919267842652 0.802213958426804 0.271908314083065 0.8445980026244 miRNATAP -0.135133363016591 0.00145239050346874 26097565;26318586 miR 106a promotes growth and metastasis of non small cell lung cancer by targeting PTEN; Furthermore the presence of miR-106a was inversely correlated with PTEN in NSCLC tissues; Overall this study suggested that miR-106a inhibited the growth and metastasis of NSCLC cells by decreasing PTEN expression;Further pterostilbene through downregulation of miR-17-5p and miR-106a-5p expression both in tumors and systemic circulation rescued PTEN mRNA and protein levels leading to reduced tumor growth in vivo metastasis; lung squamous cell cancer;prostate cancer hsa-miR-188-5p PTEN 0.56851767054255 0.324820848307955 0.271908314083065 0.8445980026244 MirTarget;PITA;miRNATAP -0.101903000516257 0.0012689580885123 NA NA NA hsa-miR-193a-3p PTEN 0.247265785363731 0.654363581941635 0.271908314083065 0.8445980026244 PITA;miRanda -0.103528410753244 0.0102627304058381 26753960;23223432 Downregulation of microRNA 193 3p inhibits tumor proliferation migration and chemoresistance in human gastric cancer by regulating PTEN gene;Our study identifies miR-193a and PTEN as targets for AML1/ETO and provides evidence that links the epigenetic silencing of tumor suppressor genes miR-193a and PTEN to differentiation block of myeloid precursors drug resistance;differentiation gastric cancer;acute myeloid leukemia hsa-miR-29b-3p PTEN 0.104016192263954 0.958988036765397 0.271908314083065 0.8445980026244 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.118521083357978 0.00549994580612497 26471361;23179556;26063204;21359530 Mechanistically ATDC exerted its oncogenic effects by suppressing miR-29 and subsequent upregulation of DNMT3A leading to DNA methylation and silencing of the tumor suppressor PTEN;Anticancer role of MUC1 aptamer miR 29b chimera in epithelial ovarian carcinoma cells through regulation of PTEN methylation; Our study indicated that Chi-29b chimera can effectively exert antitumor effect through specific delivery of miR-29b into OVCAR-3 tumor cells subsequently reexpressing PTEN gene and inducing cell apoptosis;Furthermore the dual-luciferase reporter assay demonstrated that miR-29b inhibited the expression of the luciferase gene containing the 3'-UTRs of MMP2 and PTEN mRNA;In contrast enhanced miR-29b expression by transfection with pre-miR-29b decreased the expression of PTEN and impaired apoptosis increasing tumor cell migration and invasion; Moreover PTEN was shown to be a direct target of miR-29b and was also shown to contribute to the miR-29b-mediated effects on cell invasion; Modulation of miR-29b altered the role of PTEN involved in cell migration and invasion; Aberrant expression of miR-29b which modulates PTEN expression can contribute to migration invasion and anti-apoptosis ;;;cell migration bladder cancer;ovarian cancer;lung squamous cell cancer;breast cancer hsa-miR-454-3p PTEN 0.101514866328012 0.84354515825619 0.271908314083065 0.8445980026244 MirTarget;miRNATAP -0.120918689605046 0.0186651140584822 26296312;27261580 MicroRNA 454 functions as an oncogene by regulating PTEN in uveal melanoma; Furthermore we identified PTEN as a direct target of miR-454; Our data revealed that ectopic expression of PTEN restored the effects of miR-454 on cell proliferation and invasion in uveal melanoma cells;MiR 454 promotes the progression of human non small cell lung cancer and directly targets PTEN; At last the potential regulatory function of miR-454 on PTEN expression was confirmed; Further PTEN was confirmed as a direct target of miR-454 by using Luciferase Reporter Assay ;progression melanoma;lung squamous cell cancer hsa-miR-425-5p PTPN7 0.354606074344121 0.845979106734409 0.971964426632788 0.215118211786301 MirTarget -0.225664838651915 0.0337237016914669 NA NA NA hsa-miR-425-5p PTPRT 0.354606074344121 0.845979106734409 -0.382878982700508 0.660300390396461 mirMAP -0.535011950365216 2.26299251980459e-05 NA NA NA hsa-miR-425-5p QKI 0.354606074344121 0.845979106734409 -0.181349489722571 0.863868934807386 miRNAWalker2_validate -0.45315409362993 1.15696811544356e-12 NA NA NA hsa-miR-425-5p RAB8B 0.354606074344121 0.845979106734409 0.0902950837400729 0.927903533972231 miRNATAP -0.246910080181876 2.38068122553953e-11 NA NA NA hsa-miR-425-5p RABGAP1L 0.354606074344121 0.845979106734409 0.00846225757644037 0.992216014796106 miRNATAP -0.161798733876208 6.78391148675716e-06 NA NA NA hsa-miR-425-5p RGS13 0.354606074344121 0.845979106734409 0.257988349656269 0.751703570639476 MirTarget -0.369262971907019 0.00614934162151184 NA NA NA hsa-miR-425-5p RNF11 0.354606074344121 0.845979106734409 0.0149782736001516 0.990968564931193 MirTarget;miRNATAP -0.12827643057976 4.97188012405704e-06 NA NA NA hsa-miR-425-5p RNF168 0.354606074344121 0.845979106734409 0.338149268460761 0.620838986199101 MirTarget -0.1188477538956 0.00349649092874074 NA NA NA hsa-miR-425-5p RYR2 0.354606074344121 0.845979106734409 -0.559737160253285 0.288332073279517 MirTarget -0.621336167203354 2.75459361253947e-07 NA NA NA hsa-miR-425-5p SAMD4A 0.354606074344121 0.845979106734409 -0.0422491505547384 0.961731787304657 miRNATAP -0.390874968871047 9.10535370749278e-11 NA NA NA hsa-miR-425-5p SCN4B 0.354606074344121 0.845979106734409 -0.492066768426304 0.207698283982067 mirMAP -0.544241197511909 1.00506575294664e-09 NA NA NA hsa-miR-425-5p SERPINE1 0.354606074344121 0.845979106734409 -0.966819512871612 0.431832134223423 MirTarget;miRNATAP -0.539837029629402 3.22785867994715e-09 NA NA NA hsa-miR-425-5p SLC1A2 0.354606074344121 0.845979106734409 0.158997851251133 0.807693689140663 mirMAP -0.373777276937359 2.92197439373214e-05 NA NA NA hsa-miR-425-5p SMAD4 0.354606074344121 0.845979106734409 0.473107439957933 0.714784528258548 mirMAP -0.130531407894903 0.00133502406681675 NA NA NA hsa-miR-425-5p SNAP91 0.354606074344121 0.845979106734409 -0.204899818298964 0.848323726421424 miRNATAP -0.783309900924995 5.75075930036651e-10 NA NA NA hsa-miR-425-5p SSBP2 0.354606074344121 0.845979106734409 -0.658949563143923 0.185741057623419 mirMAP -0.475158720682851 3.51731756974522e-08 NA NA NA hsa-miR-425-5p SYNJ1 0.354606074344121 0.845979106734409 -0.0758974602647906 0.919075847261696 miRNATAP -0.101654894245476 0.001329047811672 NA NA NA hsa-miR-425-5p SYT2 0.354606074344121 0.845979106734409 -0.631128921635581 0.170831190605868 mirMAP -0.188626987641222 0.0200018417428074 NA NA NA hsa-miR-425-5p TAOK1 0.354606074344121 0.845979106734409 0.00511870860271202 0.995099673202883 miRNAWalker2_validate -0.22972866277421 1.37916046631797e-05 NA NA NA hsa-miR-425-5p TBCEL 0.354606074344121 0.845979106734409 0.0732531967319074 0.919506087322031 MirTarget -0.200441187946229 5.29491671575864e-05 NA NA NA hsa-miR-425-5p TEAD1 0.354606074344121 0.845979106734409 -0.0216902727971418 0.987512880139533 mirMAP -0.11623892030302 0.0002650469705325 NA NA NA hsa-miR-425-5p THEMIS 0.354606074344121 0.845979106734409 0.888625045505686 0.0541343522384549 MirTarget -0.355307951785886 0.000942359921143182 NA NA NA hsa-miR-425-5p THRB 0.354606074344121 0.845979106734409 -0.138527169759115 0.845219678691709 MirTarget;miRNATAP -0.350280713456607 0.00812562638652289 NA NA NA hsa-miR-425-5p TIFAB 0.354606074344121 0.845979106734409 1.10510327368013 0.0929122614988927 mirMAP -0.285328774987778 0.0128687100500927 NA NA NA hsa-miR-425-5p TNC 0.354606074344121 0.845979106734409 -0.416601359196189 0.785495780663201 MirTarget -0.850714410407433 1.10857894452288e-14 NA NA NA hsa-miR-425-5p TNS1 0.354606074344121 0.845979106734409 -0.376974651675178 0.79549562945526 mirMAP -0.879605854793122 8.02086455616924e-24 24571667 Here we show that IL-1β induces the upregulation of miR-425 which negatively regulates phosphatase and tensin homolog expression by targeting its 3' UTR; Consequently repression of phosphatase and tensin homolog by miR-425 promotes gastric cancer cell proliferation which is required to protect cells from cisplatin-induced apoptosis; Taken together our data support a critical role for NF-kappaB-dependent upregulation of miR-425 which represents a new pathway for the repression of phosphatase and tensin homolog activation and the promotion of cell survival upon IL-1β induction poor survival gastric cancer hsa-miR-425-5p TTC9 0.354606074344121 0.845979106734409 -0.39050885195407 0.631414761184418 mirMAP -0.236131363778621 0.00797180738647017 NA NA NA hsa-miR-425-5p WDR7 0.354606074344121 0.845979106734409 0.189780971185205 0.824812474010923 mirMAP -0.179217685378722 2.93306108463937e-06 NA NA NA hsa-miR-425-5p WTIP 0.354606074344121 0.845979106734409 -0.399973275735342 0.408138316114152 mirMAP -0.428098680947725 5.96901532547516e-11 NA NA NA hsa-miR-425-5p ZFP82 0.354606074344121 0.845979106734409 -0.362655424095407 0.36071969406169 MirTarget -0.395668777932982 1.51832814286583e-05 NA NA NA hsa-miR-425-5p ZMAT3 0.354606074344121 0.845979106734409 0.325283318095947 0.503935903211142 MirTarget -0.271424474292441 5.32072386787997e-06 NA NA NA hsa-miR-425-5p ZNF423 0.354606074344121 0.845979106734409 -0.941316164552042 0.108611202337543 MirTarget;miRNATAP -0.29576761811083 0.00148415379721555 NA NA NA hsa-miR-425-5p ZNF677 0.354606074344121 0.845979106734409 -0.330242327733008 0.60182456622836 mirMAP -0.552950640388341 2.16006165445656e-10 NA NA NA