miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-140-5p DNPEP -0.755971041589807 9.68060922934542e-14 0.471519729362952 5.57428314365212e-15 miRTarBase -0.160140880983574 1.67857814594697e-15 NA NA NA hsa-miR-140-5p SOX2 -0.755971041589807 9.68060922934542e-14 1.62824878642595 1.83270623627945e-06 miRTarBase -0.260852621786827 0.0229665657143227 23060440;25426255 We found that the stem cell self-renewal regulator SOX2 is a novel target of miR-140 and that this miR-140/SOX2 pathway critically regulates breast tumor-initiating cell survival providing a new link between ERĪ± signaling and breast cancer stem cell maintenance;miR-140 plays an important tumor suppressive role in the Wnt SOX2 and SOX9 stem cell regulator pathways poor survival; breast cancer;breast cancer