miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-199b-5p AADAC -0.454049170125872 0.254611775331658 -1.53356480638852 1.2937396141924e-06 miRanda -0.163887267083247 3.58577799422923e-05 NA NA NA hsa-miR-199b-5p AADAT -0.454049170125872 0.254611775331658 -3.70371787150349 3.04352178812431e-38 miRanda -0.149345353902899 0.000128375275087298 NA NA NA hsa-miR-301a-3p ABCA1 0.842910511640361 1.43446467417891e-06 -1.09636606966708 7.96780532063531e-16 miRNATAP -0.125248434637132 0.00125156770625097 NA NA NA hsa-miR-301a-3p ABCB7 0.842910511640361 1.43446467417891e-06 -0.336537326932062 4.10634723271211e-05 MirTarget;miRNATAP -0.107927002188864 1.60474235770964e-06 NA NA NA hsa-let-7c-5p ABCB9 -1.70744661345097 2.87934212005942e-20 1.00955603859492 1.63896842371547e-09 MirTarget -0.273859383833607 6.80741103254938e-11 NA NA NA hsa-miR-195-5p ABCB9 -1.85907534356434 1.47434041676402e-22 1.00955603859492 1.63896842371547e-09 mirMAP -0.103848862573717 0.012288912584917 NA NA NA hsa-let-7c-5p ABCC10 -1.70744661345097 2.87934212005942e-20 1.42399346571582 1.7634577339245e-36 MirTarget -0.301575187605271 5.72062761788124e-25 NA NA NA hsa-miR-101-3p ABCC5 -1.48176407980989 3.98950707385704e-31 1.23282495059029 1.29865153692267e-30 MirTarget;miRNATAP -0.467176848163805 1.9912381678643e-35 NA NA NA hsa-miR-195-5p ABCC5 -1.85907534356434 1.47434041676402e-22 1.23282495059029 1.29865153692267e-30 MirTarget;miRNATAP -0.167374828413613 1.1816546812374e-09 NA NA NA hsa-miR-199b-5p ABCC6 -0.454049170125872 0.254611775331658 -0.917487753058001 7.69038192376142e-07 miRanda -0.104167391201715 7.05138730079018e-06 NA NA NA hsa-miR-199a-5p ABCC6P2 -1.98848462405923 2.0421622713753e-11 0.579350425677049 0.000270490427142673 miRanda -0.128976764421786 3.483874737635e-07 NA NA NA hsa-miR-199b-5p ABCG2 -0.454049170125872 0.254611775331658 -1.7076806057577 2.07418898418233e-09 miRanda -0.185269100755893 2.15130845632842e-07 NA NA NA hsa-miR-301a-3p ABHD2 0.842910511640361 1.43446467417891e-06 -1.20462139360653 3.09717296882448e-15 mirMAP -0.375328897758533 2.39328024328128e-19 NA NA NA hsa-miR-199b-5p ABHD6 -0.454049170125872 0.254611775331658 -1.31098377221704 2.90575133173284e-15 miRanda -0.124504699376627 3.16339542562795e-09 NA NA NA hsa-miR-101-3p ABI2 -1.48176407980989 3.98950707385704e-31 0.140168313926931 0.173394233347582 miRNATAP -0.241249512413071 1.26565536036736e-11 NA NA NA hsa-miR-301a-3p ABTB2 0.842910511640361 1.43446467417891e-06 -0.433245274232974 0.00309618873065253 mirMAP -0.209561708948328 1.62186415700769e-07 NA NA NA hsa-miR-101-3p ACBD3 -1.48176407980989 3.98950707385704e-31 0.278220257794248 0.00131416785662347 miRNATAP -0.13166053909207 1.64464104445141e-05 NA NA NA hsa-miR-301a-3p ACBD5 0.842910511640361 1.43446467417891e-06 -0.747355613421877 3.97123554106721e-11 MirTarget;miRNATAP -0.251534831953132 3.13948655958143e-16 NA NA NA hsa-miR-199b-5p ACOT13 -0.454049170125872 0.254611775331658 -0.49452897419981 3.19753711011614e-05 miRanda -0.136505617662594 5.12180027225139e-22 NA NA NA hsa-miR-301a-3p ACSL1 0.842910511640361 1.43446467417891e-06 -2.33415071716027 1.71568734924942e-22 MirTarget;miRNATAP -0.564045644980432 4.15079136425692e-17 NA NA NA hsa-miR-101-3p ACSL4 -1.48176407980989 3.98950707385704e-31 2.07128895001209 1.06074462060898e-08 miRNATAP -0.888884670764269 3.53208845222037e-12 NA NA NA hsa-miR-195-5p ACSL4 -1.85907534356434 1.47434041676402e-22 2.07128895001209 1.06074462060898e-08 MirTarget;miRNATAP -0.439990657344658 6.87615027124012e-07 NA NA NA hsa-miR-199a-5p ACTN2 -1.98848462405923 2.0421622713753e-11 1.96170209752505 2.48204451462246e-05 miRanda -0.225721132502598 0.00264493493357462 NA NA NA hsa-miR-199b-5p ACTN2 -0.454049170125872 0.254611775331658 1.96170209752505 2.48204451462246e-05 miRanda -0.185854205647351 0.00143185400709665 NA NA NA hsa-miR-101-3p ADAMTS10 -1.48176407980989 3.98950707385704e-31 0.72666035489938 0.0018715247175307 miRNATAP -0.27916152272782 0.000785904852621794 NA NA NA hsa-miR-199a-5p ADCK5 -1.98848462405923 2.0421622713753e-11 0.840835582665551 1.32162389059078e-10 miRanda -0.105365655459162 6.49846306442523e-07 NA NA NA hsa-miR-301a-3p ADCY1 0.842910511640361 1.43446467417891e-06 -2.70370487380383 7.2704291027202e-13 MirTarget;miRNATAP -0.398815088871954 0.000182432785348608 NA NA NA hsa-miR-101-3p ADCY6 -1.48176407980989 3.98950707385704e-31 1.2491833959113 3.10957713063109e-35 miRNATAP -0.336086026750829 2.20446452597928e-19 NA NA NA hsa-miR-199b-5p ADH4 -0.454049170125872 0.254611775331658 -4.40804564851669 1.73564709524747e-15 miRanda -0.193135115996661 0.00683475490247671 NA NA NA hsa-miR-199a-5p ADH6 -1.98848462405923 2.0421622713753e-11 -2.16774441343866 1.0268718795787e-13 miRanda -0.108300834967416 0.0246204047246152 NA NA NA hsa-miR-199b-5p ADH6 -0.454049170125872 0.254611775331658 -2.16774441343866 1.0268718795787e-13 miRanda -0.21030827393441 1.12955726364455e-08 NA NA NA hsa-miR-199b-5p ADHFE1 -0.454049170125872 0.254611775331658 -1.32637826010337 1.34650434599866e-08 miRanda -0.179455554761236 6.14865763109388e-10 NA NA NA hsa-miR-301a-3p AFF1 0.842910511640361 1.43446467417891e-06 -0.706365229864835 1.27878377206924e-10 MirTarget -0.164136809533535 7.58849773610638e-08 NA NA NA hsa-miR-101-3p AGAP1 -1.48176407980989 3.98950707385704e-31 0.518288747294649 6.1455477928265e-07 MirTarget -0.211634811468157 8.35059506465139e-09 NA NA NA hsa-miR-199a-5p AGBL5 -1.98848462405923 2.0421622713753e-11 0.719216662189634 5.45155911410886e-12 miRanda -0.130005272808645 4.12949701572692e-15 NA NA NA hsa-miR-101-3p AGFG1 -1.48176407980989 3.98950707385704e-31 0.233561308470791 0.00166240907735505 MirTarget -0.12484260401143 1.70701681414596e-06 NA NA NA hsa-miR-199b-5p AGXT2 -0.454049170125872 0.254611775331658 -2.8852136241323 1.77795496865525e-13 miRanda -0.155016293573436 0.00200220372723476 NA NA NA hsa-miR-199b-5p AKAP6 -0.454049170125872 0.254611775331658 -0.968677768825482 1.23169099553274e-07 miRanda -0.106984037899155 3.00829915238745e-06 NA NA NA hsa-miR-199a-5p AKR1C2 -1.98848462405923 2.0421622713753e-11 0.250638024890982 0.398417438529999 miRanda -0.185818308200431 8.31801515041577e-05 NA NA NA hsa-miR-199b-5p AKR1C2 -0.454049170125872 0.254611775331658 0.250638024890982 0.398417438529999 miRanda -0.15619202288378 2.00591719641103e-05 NA NA NA hsa-miR-21-5p AKT2 1.51084295924322 1.54551622173259e-34 -0.343608685894869 1.25471482871759e-05 miRNAWalker2_validate -0.246625533117166 4.43585626011661e-19 NA NA NA hsa-miR-330-5p AKT2 0.442231058604099 0.0053308560843808 -0.343608685894869 1.25471482871759e-05 miRanda -0.10429759179516 1.49133299948889e-05 NA NA NA hsa-miR-342-3p AKT2 -0.319677314984262 0.0449813878317147 -0.343608685894869 1.25471482871759e-05 mirMAP -0.124944719707983 1.72780303356483e-07 NA NA NA hsa-miR-106b-5p AKT3 0.648901865047099 8.24870862047885e-09 -0.658799312069129 0.000471762262250455 miRNATAP -0.257549207275002 0.00147770551388523 NA NA NA hsa-miR-107 AKT3 0.241662461253461 0.0170788899505389 -0.658799312069129 0.000471762262250455 PITA;miRanda -0.603074134996255 1.95007791380395e-11 NA NA NA hsa-miR-122-5p AKT3 -1.23907441373955 4.42181244888642e-06 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase -0.282597613468804 3.13172096832783e-18 24244539 miR 122 regulates tumorigenesis in hepatocellular carcinoma by targeting AKT3; Here we identify AKT3 as a novel and direct target of miR-122; Restoration of miR-122 expression in HCC cell lines decreases AKT3 levels inhibits cell migration and proliferation and induces apoptosis; These anti-tumor phenotypes can be rescued by reconstitution of AKT3 expression indicating the essential role of AKT3 in miR-122 mediated HCC transformation; Our data strongly suggest that miR-122 is a tumor suppressor that targets AKT3 to regulate tumorigenesis in HCCs and a potential therapeutic candidate for liver cancer tumorigenesis;cell migration liver cancer hsa-miR-146b-5p AKT3 0.419719546795449 0.0457375823220155 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate -0.159678144375669 0.000263366078999813 NA NA NA hsa-miR-15a-5p AKT3 0.349521211668244 0.000770735998804736 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265425410812535 0.00291348888530609 NA NA NA hsa-miR-17-3p AKT3 0.410352776142368 0.00422200500748636 -0.658799312069129 0.000471762262250455 miRNATAP -0.350392140268267 3.46133659001702e-08 NA NA NA hsa-miR-17-5p AKT3 0.698861147045461 2.43854106455398e-05 -0.658799312069129 0.000471762262250455 TargetScan;miRNATAP -0.290786763807918 1.04942988053081e-07 NA NA NA hsa-miR-20a-5p AKT3 0.854326758727003 5.04256669663285e-07 -0.658799312069129 0.000471762262250455 miRNATAP -0.294574079686222 2.60181650003526e-08 NA NA NA hsa-miR-32-3p AKT3 0.219109440121582 0.207217051619543 -0.658799312069129 0.000471762262250455 mirMAP -0.225932925933496 3.62088303609835e-05 NA NA NA hsa-miR-33a-3p AKT3 -0.683025859637737 1.01106097756419e-05 -0.658799312069129 0.000471762262250455 mirMAP -0.229716914608906 0.000100074832030455 NA NA NA hsa-miR-362-3p AKT3 0.814007335895913 2.00108618836568e-09 -0.658799312069129 0.000471762262250455 miRanda -0.223301194831745 0.00083465748836002 NA NA NA hsa-miR-362-5p AKT3 0.717921690799312 1.68392734504524e-05 -0.658799312069129 0.000471762262250455 PITA;TargetScan;miRNATAP -0.147261080417749 0.00734435768679755 NA NA NA hsa-miR-374a-5p AKT3 0.016390363747302 0.869784217438621 -0.658799312069129 0.000471762262250455 mirMAP -0.277843537840681 0.00293899073092604 NA NA NA hsa-miR-421 AKT3 0.941856334694081 6.12167297054077e-08 -0.658799312069129 0.000471762262250455 miRanda;mirMAP -0.133809007743249 0.0109099775591746 NA NA NA hsa-miR-501-3p AKT3 0.999540908940094 2.77358485581974e-11 -0.658799312069129 0.000471762262250455 miRNATAP -0.119128898090902 0.0482272940757398 NA NA NA hsa-miR-502-3p AKT3 0.659598854007546 3.01316453996423e-08 -0.658799312069129 0.000471762262250455 miRNATAP -0.256952206617794 0.000795069967308112 NA NA NA hsa-miR-616-5p AKT3 0.150569904638223 0.402836556304524 -0.658799312069129 0.000471762262250455 mirMAP -0.200000357827185 9.73725948226915e-05 NA NA NA hsa-miR-93-5p AKT3 1.39518349670953 2.84167728726712e-25 -0.658799312069129 0.000471762262250455 miRNATAP -0.283992832133781 1.04884093066001e-05 NA NA NA hsa-miR-199a-5p ALDH1L1 -1.98848462405923 2.0421622713753e-11 -1.79897057978168 4.21691734123932e-06 miRanda -0.210895086391671 0.000839168490998127 NA NA NA hsa-miR-199b-5p ALDH1L1 -0.454049170125872 0.254611775331658 -1.79897057978168 4.21691734123932e-06 miRanda -0.333490510877753 3.69202010261254e-12 NA NA NA hsa-miR-301a-3p ALDH5A1 0.842910511640361 1.43446467417891e-06 -1.10134059033742 2.89516754967917e-11 mirMAP -0.40836290273233 6.6284848184044e-20 NA NA NA hsa-miR-199a-5p ALKBH2 -1.98848462405923 2.0421622713753e-11 0.581016329227139 2.08488809087609e-05 miRanda -0.143530786309932 2.68114456331912e-11 NA NA NA hsa-miR-199b-5p ALKBH2 -0.454049170125872 0.254611775331658 0.581016329227139 2.08488809087609e-05 miRanda -0.107810808371043 1.2731967554743e-10 NA NA NA hsa-miR-101-3p AMMECR1 -1.48176407980989 3.98950707385704e-31 0.07463984932527 0.450930997632238 miRNATAP -0.10957653117107 0.00172170503257944 NA NA NA hsa-miR-301a-3p AMOTL1 0.842910511640361 1.43446467417891e-06 -0.530839640793762 0.026029167727027 mirMAP -0.160357353801854 0.0149731094697259 NA NA NA hsa-miR-199a-5p ANKAR -1.98848462405923 2.0421622713753e-11 0.959037794565761 2.94199851855109e-13 miRanda -0.120098519314271 1.79015771102048e-08 NA NA NA hsa-miR-195-5p ANKRD13D -1.85907534356434 1.47434041676402e-22 0.793371386887663 1.12366210337644e-10 MirTarget -0.108530536358292 0.000360049339249101 NA NA NA hsa-miR-199a-5p ANKRD26P1 -1.98848462405923 2.0421622713753e-11 0.428268787717821 0.214849390819305 miRanda -0.15659161413165 0.00456565836290399 NA NA NA hsa-miR-101-3p ANKRD27 -1.48176407980989 3.98950707385704e-31 0.900670804616695 4.42329061698872e-15 mirMAP -0.334300824925786 2.04631279680808e-16 NA NA NA hsa-let-7c-5p ANKRD49 -1.70744661345097 2.87934212005942e-20 0.399680304237402 6.46826622613075e-08 MirTarget -0.100989362644086 4.78554482063786e-08 NA NA NA hsa-miR-101-3p ANKRD52 -1.48176407980989 3.98950707385704e-31 1.45719998646575 1.747377108051e-36 miRNATAP -0.498466559858091 2.03805584537862e-33 NA NA NA hsa-miR-199a-3p ANKRD52 -2.3279328685682 1.04468066198593e-17 1.45719998646575 1.747377108051e-36 PITA;miRNATAP -0.108833011429576 3.97550251967124e-07 NA NA NA hsa-miR-101-3p ANKZF1 -1.48176407980989 3.98950707385704e-31 0.847749468566496 1.02258150197508e-21 MirTarget -0.190389485245791 4.60081232080323e-09 NA NA NA hsa-miR-301a-3p AP1G1 0.842910511640361 1.43446467417891e-06 -0.476980051128284 2.74183835894147e-09 miRNATAP -0.191518379024642 5.33268447092518e-19 NA NA NA hsa-miR-101-3p AP1S3 -1.48176407980989 3.98950707385704e-31 0.345293874799323 0.0174721921410757 miRNAWalker2_validate -0.275338856652359 6.59010601927223e-08 NA NA NA hsa-miR-199a-3p AP3B1 -2.3279328685682 1.04468066198593e-17 0.632267344636405 1.63239533876199e-17 PITA -0.101077602181005 2.85213278192496e-15 NA NA NA hsa-miR-301a-3p AP3S2 0.842910511640361 1.43446467417891e-06 -0.334623387305721 3.54194346711053e-05 mirMAP -0.165151268305725 2.98232996100091e-14 NA NA NA hsa-miR-301a-3p APBB2 0.842910511640361 1.43446467417891e-06 -0.236685537022579 0.0308537760053906 mirMAP -0.134667863885985 6.95944041588863e-06 NA NA NA hsa-miR-199a-5p APC2 -1.98848462405923 2.0421622713753e-11 1.72078641102954 8.65364092042936e-19 mirMAP -0.101465825144385 0.0017784302528151 NA NA NA hsa-miR-195-5p APLN -1.85907534356434 1.47434041676402e-22 3.68748588694903 4.52095574250086e-43 MirTarget;miRNATAP -0.631140618192199 8.52779214167576e-20 NA NA NA hsa-miR-199b-5p APOC1 -0.454049170125872 0.254611775331658 -0.965895816726722 6.13561445797999e-05 miRanda -0.164174623381973 3.58209678407635e-08 NA NA NA hsa-miR-199b-5p AQP11 -0.454049170125872 0.254611775331658 -0.625509610958238 0.000644636047632557 miRNATAP -0.132278619741189 4.37336460725433e-09 NA NA NA hsa-miR-301a-3p AR 0.842910511640361 1.43446467417891e-06 -2.65514434874701 6.79656050811819e-11 mirMAP;miRNATAP -1.0588536224098 3.18593631847295e-22 25940439 Mechanism dissection revealed infiltrating pre-adipocytes might function through down-regulation of the androgen receptor AR via modulation of miR-301a and then increase PCa cell invasion via induction of TGF-β1/Smad/MMP9 signals prostate cancer hsa-miR-195-5p ARFGAP1 -1.85907534356434 1.47434041676402e-22 0.643781870064428 1.44556855471158e-13 mirMAP -0.14712993153697 3.93140220083513e-12 NA NA NA hsa-miR-301a-3p ARFIP1 0.842910511640361 1.43446467417891e-06 -0.205877254967544 0.00812115232004465 miRNATAP -0.119550554739479 1.39356415137032e-08 NA NA NA hsa-miR-301a-3p ARHGEF12 0.842910511640361 1.43446467417891e-06 -0.860756828496805 1.466966277395e-15 MirTarget;miRNATAP -0.231094706187456 9.10493424835742e-15 NA NA NA hsa-miR-101-3p ARHGEF3 -1.48176407980989 3.98950707385704e-31 0.514078801527087 0.00381491088892432 MirTarget -0.413632763621751 2.36528918665375e-11 NA NA NA hsa-miR-195-5p ARL2 -1.85907534356434 1.47434041676402e-22 0.8181016452907 1.3449124066802e-09 MirTarget;miRNATAP -0.145299198083666 1.17888220985579e-05 NA NA NA hsa-miR-301a-3p ARL6IP1 0.842910511640361 1.43446467417891e-06 -0.852576906562765 1.79492972834175e-15 MirTarget -0.144149661352436 1.92586517332117e-06 NA NA NA hsa-miR-301a-3p ARMC5 0.842910511640361 1.43446467417891e-06 -0.651415856794464 1.25785383667628e-05 mirMAP -0.267405235076058 4.5665885895064e-11 NA NA NA hsa-miR-101-3p ARNTL2 -1.48176407980989 3.98950707385704e-31 0.0223855120215825 0.941117167316514 MirTarget -0.415792815995128 0.000101906981424977 NA NA NA hsa-miR-301a-3p ARRDC3 0.842910511640361 1.43446467417891e-06 -0.701093957153481 3.22762889898878e-06 miRNATAP -0.111336610500385 0.00797070856745584 NA NA NA hsa-miR-301a-3p ART4 0.842910511640361 1.43446467417891e-06 -1.74425490375507 1.67364109265157e-09 mirMAP -0.417162520684821 2.18470599268612e-07 NA NA NA hsa-miR-101-3p ASAP1 -1.48176407980989 3.98950707385704e-31 0.602171250732936 1.27059865202179e-05 MirTarget;miRNATAP -0.4162709048842 1.66421810347008e-18 NA NA NA hsa-miR-199a-5p ASB4 -1.98848462405923 2.0421622713753e-11 -0.619984466341846 0.0668344671524796 miRanda -0.168853712669734 0.00179957620134974 NA NA NA hsa-miR-199b-5p ASB4 -0.454049170125872 0.254611775331658 -0.619984466341846 0.0668344671524796 miRanda -0.215526481469539 2.20975852091163e-07 NA NA NA hsa-miR-301a-3p ASPA 0.842910511640361 1.43446467417891e-06 -2.87708424623409 2.78732403857851e-24 mirMAP -0.462733896333601 1.40166307415222e-08 NA NA NA hsa-miR-301a-3p ASXL2 0.842910511640361 1.43446467417891e-06 -0.286455507805721 0.180509718127653 MirTarget;miRNATAP -0.148912211871845 0.0115696351034041 NA NA NA hsa-miR-301a-3p ASXL3 0.842910511640361 1.43446467417891e-06 -2.68929167531641 1.94609933734597e-13 mirMAP -0.644798590754132 2.59616042855617e-10 NA NA NA hsa-miR-301a-3p ATF6 0.842910511640361 1.43446467417891e-06 -0.0173962789843944 0.870548668789807 mirMAP -0.153174738823253 1.21988756274372e-07 NA NA NA hsa-miR-101-3p ATG4D -1.48176407980989 3.98950707385704e-31 0.238017440609291 0.0358760810215454 miRTarBase -0.131671028592259 0.00104230587458148 NA NA NA hsa-miR-199a-5p ATOX1 -1.98848462405923 2.0421622713753e-11 0.43108708114564 0.00495610810534198 mirMAP -0.113755165935227 3.1124912291519e-06 NA NA NA hsa-miR-199b-5p ATOX1 -0.454049170125872 0.254611775331658 0.43108708114564 0.00495610810534198 mirMAP -0.108863161137825 7.2878575189642e-09 NA NA NA hsa-miR-101-3p ATP1B1 -1.48176407980989 3.98950707385704e-31 0.435860215585354 0.00298454483006672 miRNATAP -0.207239253655522 6.74895128753223e-05 NA NA NA hsa-miR-101-3p ATP2B1 -1.48176407980989 3.98950707385704e-31 -0.159908936957413 0.160796369285945 miRNATAP -0.119627063407495 0.00303481003329018 NA NA NA hsa-miR-101-3p ATP5G2 -1.48176407980989 3.98950707385704e-31 0.298597035583363 0.000926154613790281 miRNATAP -0.151351255158344 1.8861569066226e-06 NA NA NA hsa-miR-301a-3p ATXN7L1 0.842910511640361 1.43446467417891e-06 -0.241046795006661 0.0606470141841609 miRNATAP -0.273255527436802 1.42329014625089e-15 NA NA NA hsa-miR-195-5p ATXN7L2 -1.85907534356434 1.47434041676402e-22 1.06992494046032 6.78987290211496e-20 MirTarget;miRNATAP -0.210577364214925 3.76121572275863e-13 NA NA NA hsa-miR-195-5p ATXN7L3 -1.85907534356434 1.47434041676402e-22 0.698895357070855 3.23244219063052e-16 MirTarget;miRNATAP -0.158935577254259 2.56979286946406e-14 NA NA NA hsa-miR-195-5p AVL9 -1.85907534356434 1.47434041676402e-22 0.363254778951376 0.000323416937551397 MirTarget;miRNATAP -0.134642152440576 2.88913486876052e-08 NA NA NA hsa-miR-195-5p AXIN2 -1.85907534356434 1.47434041676402e-22 0.113841868770703 0.752977397700815 MirTarget;miRNATAP -0.245874041969712 0.00506110437798971 NA NA NA hsa-miR-101-3p B3GALNT2 -1.48176407980989 3.98950707385704e-31 0.858182539115791 7.80788493062689e-23 MirTarget -0.24548685277611 8.10035954316517e-15 NA NA NA hsa-miR-101-3p B3GNT3 -1.48176407980989 3.98950707385704e-31 0.220177525635404 0.628137933060835 MirTarget -1.38812408396308 2.54919147688493e-19 NA NA NA hsa-miR-199a-5p BAAT -1.98848462405923 2.0421622713753e-11 -1.22078391735102 1.33400127612392e-05 PITA;miRanda -0.123450092223925 0.00643432163285309 NA NA NA hsa-miR-199b-5p BAAT -0.454049170125872 0.254611775331658 -1.22078391735102 1.33400127612392e-05 PITA;miRanda -0.191548900708868 3.44997688370412e-08 NA NA NA hsa-miR-301a-3p BACH2 0.842910511640361 1.43446467417891e-06 -1.98817818659277 2.20288210770245e-15 mirMAP;miRNATAP -0.294176399905442 3.62622077191415e-05 NA NA NA hsa-miR-101-3p BAZ2A -1.48176407980989 3.98950707385704e-31 0.461073155925693 4.28128289777929e-08 MirTarget;miRNATAP -0.189929248019064 1.48259994575272e-10 NA NA NA hsa-miR-101-3p BBC3 -1.48176407980989 3.98950707385704e-31 0.804667864310401 1.64815736901645e-10 miRNATAP -0.315666699732468 1.33584521433787e-12 NA NA NA hsa-miR-101-3p BCL9 -1.48176407980989 3.98950707385704e-31 1.17619476675548 1.43287619580645e-16 miRNAWalker2_validate;MirTarget;miRNATAP -0.419415008410644 1.19423457848627e-16 NA NA NA hsa-miR-101-3p BEGAIN -1.48176407980989 3.98950707385704e-31 -0.416894804699425 0.217379973266223 MirTarget -0.247757110282493 0.0393154249730051 NA NA NA hsa-miR-199b-5p BHMT -0.454049170125872 0.254611775331658 -3.29256365522959 1.6634185509732e-13 miRanda -0.347405543528557 6.45613706064036e-10 NA NA NA hsa-miR-101-3p BIRC5 -1.48176407980989 3.98950707385704e-31 4.49515004999251 9.61981227851246e-50 miRNAWalker2_validate -1.3265120823297 7.97415084582345e-32 NA NA NA hsa-miR-199b-5p BLCAP -0.454049170125872 0.254611775331658 -0.40718265160047 0.000208400422206877 PITA;miRanda;miRNATAP -0.104647135842474 3.11491217667199e-15 NA NA NA hsa-miR-301a-3p BLCAP 0.842910511640361 1.43446467417891e-06 -0.40718265160047 0.000208400422206877 MirTarget;miRNATAP -0.171582537007275 1.00292442695867e-08 NA NA NA hsa-miR-301a-3p BMP6 0.842910511640361 1.43446467417891e-06 -1.04070882636827 2.86680404280335e-07 MirTarget -0.142411515985238 0.0120618957133615 NA NA NA hsa-miR-301a-3p BMPR2 0.842910511640361 1.43446467417891e-06 -0.735692104466334 2.00485450351153e-12 MirTarget;miRNATAP -0.109852401653794 0.000191922548679836 NA NA NA hsa-miR-199a-5p BRCA1 -1.98848462405923 2.0421622713753e-11 0.887514961709891 4.67672259806692e-08 miRanda -0.144408816004622 2.90833289561191e-08 NA NA NA hsa-miR-195-5p BRPF3 -1.85907534356434 1.47434041676402e-22 0.347912163638623 0.00299376429932645 miRNATAP -0.14654284274149 1.98163899914228e-07 NA NA NA hsa-miR-195-5p BSG -1.85907534356434 1.47434041676402e-22 0.897527720483454 7.06356776326638e-15 mirMAP -0.136774701999594 1.8115012757011e-06 NA NA NA hsa-miR-199a-5p BSN -1.98848462405923 2.0421622713753e-11 0.943588815475765 2.35563209281755e-05 miRanda -0.140811958551519 8.61104388416995e-05 NA NA NA hsa-miR-101-3p BTBD3 -1.48176407980989 3.98950707385704e-31 0.299640501202244 0.00861061458292312 miRNATAP -0.157223061993273 9.69462740489036e-05 NA NA NA hsa-miR-101-3p BTG2 -1.48176407980989 3.98950707385704e-31 -0.630184582086319 0.000279781600661663 miRNAWalker2_validate -0.143387242038904 0.020801311056934 NA NA NA hsa-miR-199a-5p BTNL9 -1.98848462405923 2.0421622713753e-11 0.267608210653354 0.250124476740129 miRanda -0.106028073904219 0.00435615458920632 NA NA NA hsa-miR-199b-5p BTNL9 -0.454049170125872 0.254611775331658 0.267608210653354 0.250124476740129 miRanda -0.189688960770172 1.93380487271812e-11 NA NA NA hsa-miR-199a-5p BUB1 -1.98848462405923 2.0421622713753e-11 4.04762666744344 9.60341711300894e-48 miRanda -0.291631300567174 3.71128271880203e-09 NA NA NA hsa-let-7c-5p BZW2 -1.70744661345097 2.87934212005942e-20 0.577245550489843 7.10575922293368e-08 MirTarget -0.203335965765395 1.43522953010322e-14 NA NA NA hsa-miR-301a-3p C16orf70 0.842910511640361 1.43446467417891e-06 -0.765094694813145 5.94169478628678e-11 miRNATAP -0.241178885324847 4.73517172865898e-14 NA NA NA hsa-miR-301a-3p C17orf51 0.842910511640361 1.43446467417891e-06 -0.666308125870991 0.001643343913341 mirMAP -0.23839557222189 4.29816906173771e-05 NA NA NA hsa-miR-301a-3p C1S 0.842910511640361 1.43446467417891e-06 -1.68155333684788 3.08467439829271e-19 MirTarget -0.581966668835978 5.21908920234179e-31 NA NA NA hsa-miR-199a-5p C1orf105 -1.98848462405923 2.0421622713753e-11 0.818833833854874 0.00233809411731098 miRNATAP -0.196705561212745 4.4806218313277e-06 NA NA NA hsa-miR-199b-5p C1orf105 -0.454049170125872 0.254611775331658 0.818833833854874 0.00233809411731098 miRNATAP -0.149837931037171 6.92994334774898e-06 NA NA NA hsa-miR-301a-3p C5 0.842910511640361 1.43446467417891e-06 -1.23102275495259 4.03260361038988e-10 MirTarget -0.312807634835134 1.02305486311906e-08 NA NA NA hsa-miR-195-5p C6orf223 -1.85907534356434 1.47434041676402e-22 0.669280204465648 0.189250898670159 mirMAP -0.358327280948373 0.00377643167154908 NA NA NA hsa-miR-199a-3p C9orf40 -2.3279328685682 1.04468066198593e-17 0.597133001230743 1.19639278411742e-06 miRNATAP -0.129822029656752 6.05518061094651e-10 NA NA NA hsa-miR-101-3p CA12 -1.48176407980989 3.98950707385704e-31 2.34009290257016 5.88059078525048e-07 mirMAP -1.21860958495082 1.07050099348903e-13 NA NA NA hsa-miR-199a-5p CA4 -1.98848462405923 2.0421622713753e-11 1.36469590013252 0.00143433772088175 miRanda -0.417484374722422 6.57189464946969e-10 NA NA NA hsa-miR-15a-5p CAB39 0.349521211668244 0.000770735998804736 -0.152804524606349 0.00962811714746276 miRNATAP -0.108425253583809 7.85731490720904e-05 NA NA NA hsa-miR-16-1-3p CAB39 0.392360028038559 0.00112481918108198 -0.152804524606349 0.00962811714746276 MirTarget -0.117268659952457 5.98270638213691e-07 NA NA NA hsa-miR-193a-3p CAB39 -0.117675551589896 0.309391958208578 -0.152804524606349 0.00962811714746276 MirTarget;miRanda -0.123942945247746 4.68902843877997e-07 NA NA NA hsa-miR-192-3p CAB39L -0.6401165114007 0.000266272092403814 -0.504869726858055 1.1927547950473e-05 mirMAP -0.122781017802891 0.0001220181908619 NA NA NA hsa-miR-192-5p CAB39L -0.50188499512787 0.00344713341196035 -0.504869726858055 1.1927547950473e-05 miRNAWalker2_validate -0.168189458314805 2.40399921852626e-07 NA NA NA hsa-miR-361-5p CAB39L 0.233202959858696 0.00961572812255327 -0.504869726858055 1.1927547950473e-05 MirTarget;miRanda -0.195565910720272 0.00208448717872423 NA NA NA hsa-miR-362-3p CAB39L 0.814007335895913 2.00108618836568e-09 -0.504869726858055 1.1927547950473e-05 miRanda -0.153089959329449 0.000183470156830685 NA NA NA hsa-miR-374a-3p CAB39L -0.207171354826929 0.0623494608399903 -0.504869726858055 1.1927547950473e-05 MirTarget -0.116409883482865 0.0235530963021377 NA NA NA hsa-miR-590-3p CAB39L -0.473167498047808 1.76652934637227e-05 -0.504869726858055 1.1927547950473e-05 miRanda -0.103141246174533 0.0448666468840738 NA NA NA hsa-miR-590-5p CAB39L -0.103355559980404 0.310027295317092 -0.504869726858055 1.1927547950473e-05 miRanda -0.137271393364833 0.014772112957972 NA NA NA hsa-miR-618 CAB39L 0.13539895350352 0.517145913114103 -0.504869726858055 1.1927547950473e-05 mirMAP -0.10129028583161 0.000298566594868403 NA NA NA hsa-miR-195-5p CABLES2 -1.85907534356434 1.47434041676402e-22 0.815780245768877 1.35421612402299e-10 MirTarget -0.110015633007423 0.000463476600667638 NA NA NA hsa-miR-101-3p CACNA1D -1.48176407980989 3.98950707385704e-31 0.0773051512884277 0.775671886109236 miRNATAP -0.433874608380917 5.48674401427686e-06 NA NA NA hsa-miR-195-5p CACNA1E -1.85907534356434 1.47434041676402e-22 1.61336046300478 3.88892981462269e-05 MirTarget -0.435262615554243 4.95666194322937e-06 NA NA NA hsa-miR-195-5p CACNB4 -1.85907534356434 1.47434041676402e-22 1.93077881386314 4.3815389499992e-11 miRNATAP -0.410799179945205 1.0583861816818e-08 NA NA NA hsa-miR-199a-5p CACNB4 -1.98848462405923 2.0421622713753e-11 1.93077881386314 4.3815389499992e-11 miRanda -0.124831270534033 0.00938429701298574 NA NA NA hsa-miR-301a-3p CAMK1D 0.842910511640361 1.43446467417891e-06 -0.401457997700563 0.123544927768406 mirMAP -0.213190862986435 0.00298953633881557 NA NA NA hsa-miR-101-3p CAPN2 -1.48176407980989 3.98950707385704e-31 0.655194969240925 1.21295078937538e-07 miRNAWalker2_validate;MirTarget -0.211136325324757 1.73986621368963e-06 NA NA NA hsa-miR-195-5p CARD10 -1.85907534356434 1.47434041676402e-22 0.264885311494305 0.0262885007334627 MirTarget;miRNATAP -0.112244001939024 9.70923738472656e-05 24787958 MicroRNA 195 inhibits colorectal cancer cell proliferation colony formation and invasion through targeting CARMA3 colorectal cancer hsa-miR-195-5p CARM1 -1.85907534356434 1.47434041676402e-22 0.373127679570882 1.15020359181445e-07 MirTarget -0.103017124938895 1.17862807657115e-09 NA NA NA hsa-miR-195-5p CASKIN1 -1.85907534356434 1.47434041676402e-22 1.73450894991447 2.58018983860941e-08 miRNATAP -0.350980346138939 4.25507660050901e-06 NA NA NA hsa-miR-199b-5p CAT -0.454049170125872 0.254611775331658 -1.65049060277008 8.91987155536677e-23 miRanda -0.114875334863466 1.34832942939551e-07 NA NA NA hsa-miR-101-3p CBFA2T2 -1.48176407980989 3.98950707385704e-31 1.20918131407154 1.46538376039906e-30 miRNAWalker2_validate;MirTarget;miRNATAP -0.332764679361494 7.29279212439392e-18 NA NA NA hsa-miR-199a-5p CBLN1 -1.98848462405923 2.0421622713753e-11 1.23495232475721 0.000396798258496731 miRanda -0.120418654813744 0.0322379860307126 NA NA NA hsa-miR-199b-5p CBLN1 -0.454049170125872 0.254611775331658 1.23495232475721 0.000396798258496731 miRanda -0.145208876504329 0.000847488836606656 NA NA NA hsa-miR-199a-5p CBR1 -1.98848462405923 2.0421622713753e-11 -0.129648584005806 0.462231455904606 miRanda -0.137167012766244 8.715191103595e-07 NA NA NA hsa-miR-101-3p CBX4 -1.48176407980989 3.98950707385704e-31 0.715798123604446 5.62055214425908e-11 miRNAWalker2_validate;miRNATAP -0.194784278275549 6.86210855675205e-07 NA NA NA hsa-miR-195-5p CBX4 -1.85907534356434 1.47434041676402e-22 0.715798123604446 5.62055214425908e-11 MirTarget;miRNATAP -0.175338356282358 3.8117366842269e-11 25607636 MicroRNA 195 functions as a tumor suppressor by inhibiting CBX4 in hepatocellular carcinoma; In addition western blotting and qRT-RCR results showed that both CBX4 mRNA and protein levels were downregulated upon miR-195 overexpression; Luciferase reporter assays revealed that CBX4 is a direct target gene of miR-195; In conclusion our study demonstrated that miR-195 acts as a tumor suppressor by directly targeting CBX4 in HCC liver cancer hsa-let-7c-5p CBX5 -1.70744661345097 2.87934212005942e-20 0.352720475583158 0.00158496538783418 MirTarget -0.117320573000309 2.65277493570271e-05 NA NA NA hsa-miR-101-3p CBX5 -1.48176407980989 3.98950707385704e-31 0.352720475583158 0.00158496538783418 mirMAP -0.175545810259552 8.58488096899569e-06 NA NA NA hsa-let-7c-5p CBX6 -1.70744661345097 2.87934212005942e-20 -0.135925898836227 0.562356772831778 miRNAWalker2_validate -0.147751255324137 0.0120748662714877 NA NA NA hsa-miR-199a-5p CCDC15 -1.98848462405923 2.0421622713753e-11 0.84501246882387 4.15138460462643e-10 miRanda -0.11788948953993 6.36049190550393e-08 NA NA NA hsa-miR-199b-5p CCDC152 -0.454049170125872 0.254611775331658 -1.09230945352764 5.84433015164347e-09 miRanda -0.148966884992138 1.58367555240644e-10 NA NA NA hsa-miR-101-3p CCDC18 -1.48176407980989 3.98950707385704e-31 0.668353946133468 2.92735813474572e-06 miRNATAP -0.102813430311487 0.0454517418251816 NA NA NA hsa-miR-199a-5p CCDC34 -1.98848462405923 2.0421622713753e-11 1.55209692232562 1.24615702316253e-23 miRanda -0.168415630101734 5.41279359293267e-11 NA NA NA hsa-miR-101-3p CCDC6 -1.48176407980989 3.98950707385704e-31 0.0486288224569229 0.487131811557696 mirMAP -0.15786714095065 6.11625632977705e-11 NA NA NA hsa-miR-301a-3p CCDC69 0.842910511640361 1.43446467417891e-06 -0.782491490067003 2.74271120883903e-06 mirMAP -0.122484356233317 0.00847190915621921 NA NA NA hsa-miR-301a-3p CCDC85A 0.842910511640361 1.43446467417891e-06 0.737521480033408 9.22662034200037e-05 miRNATAP -0.259350467243851 5.62538065567031e-07 NA NA NA hsa-miR-195-5p CCDC85C -1.85907534356434 1.47434041676402e-22 0.715583791803459 8.12293475957308e-09 MirTarget -0.165219665108693 4.61574555935442e-08 NA NA NA hsa-miR-199a-3p CCDC85C -2.3279328685682 1.04468066198593e-17 0.715583791803459 8.12293475957308e-09 MirTarget -0.113736928526141 1.10031873168676e-07 NA NA NA hsa-miR-101-3p CCDC88A -1.48176407980989 3.98950707385704e-31 0.586443666153583 1.17901243123154e-05 miRNATAP -0.129321630229834 0.00698976563079768 NA NA NA hsa-miR-199a-3p CCDC88A -2.3279328685682 1.04468066198593e-17 0.586443666153583 1.17901243123154e-05 miRNATAP -0.113032545123368 8.64939120245296e-07 NA NA NA hsa-miR-199a-5p CCNA2 -1.98848462405923 2.0421622713753e-11 3.36794922367745 6.53886370047174e-43 miRanda -0.274665722447149 1.39754779993059e-10 NA NA NA hsa-let-7c-5p CCNB2 -1.70744661345097 2.87934212005942e-20 4.23615330954301 1.17296327500891e-51 miRNAWalker2_validate -0.85447689630769 1.64053136609545e-30 NA NA NA hsa-miR-195-5p CCNE1 -1.85907534356434 1.47434041676402e-22 3.04640353472202 4.5986250804531e-28 miRNAWalker2_validate;MirTarget;miRNATAP -0.296870668934945 3.50489012043558e-05 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively breast cancer hsa-let-7c-5p CCNF -1.70744661345097 2.87934212005942e-20 2.17480980282222 4.71512834823536e-34 miRNAWalker2_validate;MirTarget -0.504449149504788 2.14481709469935e-28 NA NA NA hsa-miR-101-3p CCNG2 -1.48176407980989 3.98950707385704e-31 0.198342536240394 0.0998646636491728 miRNATAP -0.145457107315971 0.000642902847642846 NA NA NA hsa-miR-101-3p CCNJ -1.48176407980989 3.98950707385704e-31 -0.398192855653257 0.0818003883465896 MirTarget;miRNATAP -0.210061026981831 0.00978241021663026 NA NA NA hsa-miR-301a-3p CCNT1 0.842910511640361 1.43446467417891e-06 -0.888867136119737 0.00127505554590264 mirMAP -0.206121157976861 0.00701196067624562 NA NA NA hsa-miR-199a-5p CCT3 -1.98848462405923 2.0421622713753e-11 1.07612979295764 8.57639424228165e-26 miRanda -0.116730576874176 6.82503346141537e-12 NA NA NA hsa-miR-199b-5p CD5L -0.454049170125872 0.254611775331658 -5.25002032861267 1.15280377992151e-24 miRanda -0.165963262246665 0.0142010117953722 NA NA NA hsa-miR-301a-3p CD99L2 0.842910511640361 1.43446467417891e-06 0.241015612435113 0.0536697401468371 mirMAP -0.159564842297593 2.89231989659865e-06 NA NA NA hsa-miR-301a-3p CDADC1 0.842910511640361 1.43446467417891e-06 -0.680352220690451 3.27861198316647e-09 MirTarget -0.207410168397809 5.05575986655479e-11 NA NA NA hsa-miR-101-3p CDC123 -1.48176407980989 3.98950707385704e-31 0.39105296890831 1.29566885154452e-07 miRNAWalker2_validate -0.172856374385309 2.80661918118493e-11 NA NA NA hsa-let-7c-5p CDC25A -1.70744661345097 2.87934212005942e-20 1.92057841155944 2.96621670231863e-18 MirTarget -0.51524439141821 8.99192957021977e-21 25909324 MicroRNA let 7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma; The aim of the present study was to determine whether the cell cycle regulator CDC25A is involved in the antitumor effect of let-7c in HCC; The luciferase reporter assay showed that CDC25A was a direct target of let-7c and that let-7c inhibited the expression of CDC25A protein by directly targeting its 3' UTR; In conclusion this study indicates that let-7c suppresses HCC progression possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules progression liver cancer hsa-miR-195-5p CDC25A -1.85907534356434 1.47434041676402e-22 1.92057841155944 2.96621670231863e-18 MirTarget;miRNATAP -0.345165924677639 3.04677833261703e-10 NA NA NA hsa-miR-199a-5p CDC6 -1.98848462405923 2.0421622713753e-11 3.43409755895777 3.54117234711163e-45 miRanda -0.267112671827499 4.32680677860271e-10 NA NA NA hsa-miR-101-3p CDC7 -1.48176407980989 3.98950707385704e-31 2.01751950910415 4.47781393592943e-28 miRNAWalker2_validate -0.618519649455716 1.77004294891154e-20 NA NA NA hsa-miR-199a-5p CDC7 -1.98848462405923 2.0421622713753e-11 2.01751950910415 4.47781393592943e-28 MirTarget;miRanda -0.111439193657119 0.000381838786294689 NA NA NA hsa-miR-195-5p CDCA4 -1.85907534356434 1.47434041676402e-22 1.27278228859461 1.15861071696374e-22 miRNATAP -0.178893319070827 5.09064054588134e-08 NA NA NA hsa-miR-301a-3p CDH23 0.842910511640361 1.43446467417891e-06 -1.04547549408155 6.35414485515912e-06 mirMAP -0.413142951769771 6.22983464223377e-11 NA NA NA hsa-miR-195-5p CDK4 -1.85907534356434 1.47434041676402e-22 0.667631464196621 2.00897661385551e-11 miRNAWalker2_validate;miRTarBase -0.181976803431634 3.34979886785679e-14 NA NA NA hsa-miR-101-3p CDK5R1 -1.48176407980989 3.98950707385704e-31 1.08475307136185 2.13782053288791e-11 MirTarget;miRNATAP -0.388981165576898 1.47640407028801e-11 NA NA NA hsa-miR-195-5p CDK5R1 -1.85907534356434 1.47434041676402e-22 1.08475307136185 2.13782053288791e-11 MirTarget;miRNATAP -0.202558339170292 3.74673463217754e-07 NA NA NA hsa-miR-199a-3p CDK5R1 -2.3279328685682 1.04468066198593e-17 1.08475307136185 2.13782053288791e-11 MirTarget;miRNATAP -0.104866408958392 0.000225105750630189 NA NA NA hsa-miR-195-5p CDK6 -1.85907534356434 1.47434041676402e-22 -0.306731100792328 0.220566158555725 miRNAWalker2_validate;miRTarBase -0.257207165713251 2.04308440041189e-05 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively gastric cancer hsa-miR-199b-5p CDNF -0.454049170125872 0.254611775331658 -1.35337020492408 3.76230415608052e-15 miRanda -0.101679929451716 3.66114856532403e-06 NA NA NA hsa-miR-101-3p CDYL -1.48176407980989 3.98950707385704e-31 0.406635443252195 1.20554482771922e-07 MirTarget;miRNATAP -0.162641528662203 1.90848825116102e-09 NA NA NA hsa-let-7c-5p CECR6 -1.70744661345097 2.87934212005942e-20 0.392226039618319 0.0399877472539567 MirTarget -0.145473456803039 0.00240190908970139 NA NA NA hsa-miR-199a-5p CECR7 -1.98848462405923 2.0421622713753e-11 2.90464458618182 3.96898239134998e-05 miRanda -0.181933558917413 0.0300921138818903 NA NA NA hsa-miR-199a-5p CENPA -1.98848462405923 2.0421622713753e-11 3.96964552344392 5.7307306371057e-43 miRanda -0.330073492975421 5.7068236107784e-11 NA NA NA hsa-miR-199a-5p CENPM -1.98848462405923 2.0421622713753e-11 3.87906108166784 3.54975007620716e-44 miRanda -0.299592970864835 8.47054107810066e-10 NA NA NA hsa-miR-101-3p CENPO -1.48176407980989 3.98950707385704e-31 0.944660339121243 1.83866460846571e-08 mirMAP -0.485141244887098 1.05635343161786e-16 NA NA NA hsa-miR-301a-3p CEP120 0.842910511640361 1.43446467417891e-06 -0.38529251765269 1.61409004225275e-05 MirTarget;miRNATAP -0.131525118199397 7.52073622183874e-08 NA NA NA hsa-let-7c-5p CEP135 -1.70744661345097 2.87934212005942e-20 0.275453361086419 0.0378107269841227 MirTarget -0.128226314386056 0.000108910151993848 NA NA NA hsa-miR-450a-5p CEP350 -1.65464197503467 7.32200902934081e-23 0.488306436373169 6.10029026629057e-08 miRNATAP -0.134342025956687 5.7248792251043e-08 NA NA NA hsa-miR-195-5p CEP55 -1.85907534356434 1.47434041676402e-22 2.874986535696 2.48808404875451e-31 MirTarget -0.41531838730627 5.84505320088928e-11 NA NA NA hsa-let-7c-5p CERCAM -1.70744661345097 2.87934212005942e-20 -0.11834200381201 0.648161793551643 MirTarget -0.138379572621477 0.0336460392243724 NA NA NA hsa-miR-301a-3p CES3 0.842910511640361 1.43446467417891e-06 -1.92162410088488 4.61005196660538e-10 mirMAP -0.562334183996898 3.76057843395728e-11 NA NA NA hsa-miR-199b-5p CFL2 -0.454049170125872 0.254611775331658 -1.18046432826413 1.44423082204062e-19 miRanda -0.122500414331102 1.11047924601771e-13 NA NA NA hsa-miR-301a-3p CFL2 0.842910511640361 1.43446467417891e-06 -1.18046432826413 1.44423082204062e-19 MirTarget -0.242570853244686 4.54273418027981e-11 NA NA NA hsa-miR-199a-3p CHAD -2.3279328685682 1.04468066198593e-17 -0.971936204452971 0.000334764618282157 MirTarget;miRNATAP -0.173935024249055 0.000195324497109954 NA NA NA hsa-miR-301a-3p CHD9 0.842910511640361 1.43446467417891e-06 -0.511590175184198 2.71332522550186e-05 miRNATAP -0.276708548741797 2.0282277193833e-17 NA NA NA hsa-miR-195-5p CHEK1 -1.85907534356434 1.47434041676402e-22 1.37723795528964 1.0573870902276e-18 MirTarget;miRNATAP -0.271942240141891 1.81327823892101e-12 25840419 MiR 195 suppresses non small cell lung cancer by targeting CHEK1; We discovered that CHEK1 was a direct target of miR-195 which decreased CHEK1 expression in lung cancer cells lung squamous cell cancer hsa-miR-199a-3p CHKA -2.3279328685682 1.04468066198593e-17 1.03066945671527 4.50639789726118e-14 MirTarget;miRNATAP -0.192706877643248 1.61020354261541e-16 NA NA NA hsa-miR-199b-5p CHN2 -0.454049170125872 0.254611775331658 -0.872812918322569 8.35142132938569e-07 MirTarget;miRanda -0.161755542605018 8.29969211536743e-14 NA NA NA hsa-miR-199b-5p CHPT1 -0.454049170125872 0.254611775331658 -0.301598639063697 0.0117456295866646 miRanda -0.108730740539093 5.44098558929387e-14 NA NA NA hsa-miR-301a-3p CLCN3 0.842910511640361 1.43446467417891e-06 -0.341384908537399 0.0121834530701077 miRNATAP -0.24353072167488 3.53875362411848e-11 NA NA NA hsa-miR-195-5p CLDN19 -1.85907534356434 1.47434041676402e-22 0.664547149654215 0.101293695037712 mirMAP -0.258316007338276 0.00876808378948729 NA NA NA hsa-miR-301a-3p CLIP1 0.842910511640361 1.43446467417891e-06 -0.277457644294426 0.00917645327427696 MirTarget;miRNATAP -0.162536458253226 1.9479605109698e-08 NA NA NA hsa-miR-195-5p CLSPN -1.85907534356434 1.47434041676402e-22 2.7969110828425 3.03477840103e-20 MirTarget -0.333419785654671 1.42445703155066e-05 NA NA NA hsa-miR-199a-5p CLVS1 -1.98848462405923 2.0421622713753e-11 1.90697560004814 1.02365212947429e-06 miRanda -0.187154403400904 0.00306688223451375 NA NA NA hsa-miR-301a-3p CMPK1 0.842910511640361 1.43446467417891e-06 -0.676924575484083 5.30937933904552e-18 MirTarget;miRNATAP -0.159890203860974 2.23444371906996e-13 NA NA NA hsa-miR-301a-3p CMPK2 0.842910511640361 1.43446467417891e-06 -0.614376262866122 0.00215021044104904 MirTarget -0.247891821759656 6.53382000688316e-06 NA NA NA hsa-miR-195-5p CNIH2 -1.85907534356434 1.47434041676402e-22 1.46077555894261 7.82055795325686e-11 miRNATAP -0.244883153143349 9.96302080234343e-06 NA NA NA hsa-miR-199a-3p CNIH2 -2.3279328685682 1.04468066198593e-17 1.46077555894261 7.82055795325686e-11 MirTarget;PITA;miRNATAP -0.169119008328234 1.65227707914565e-05 NA NA NA hsa-miR-101-3p CNIH3 -1.48176407980989 3.98950707385704e-31 0.0600705248525033 0.797876723481095 MirTarget -0.317136165570897 0.000128473097877566 NA NA NA hsa-miR-199b-5p CNKSR2 -0.454049170125872 0.254611775331658 -0.547020289576205 0.157714486315915 miRanda -0.164180617670483 0.000627364481539628 NA NA NA hsa-let-7c-5p CNOT3 -1.70744661345097 2.87934212005942e-20 0.579019484348105 2.78881715385032e-17 miRNAWalker2_validate -0.137147538185394 1.56310657094192e-15 NA NA NA hsa-miR-199a-5p CNPY2 -1.98848462405923 2.0421622713753e-11 0.421559448029404 4.41276004905492e-06 miRanda -0.10343275499232 7.30636724207867e-13 NA NA NA hsa-miR-101-3p COL10A1 -1.48176407980989 3.98950707385704e-31 -0.471405266214636 0.270922521999975 miRNATAP -0.639721183936119 2.28657997193163e-05 NA NA NA hsa-let-7c-5p COL24A1 -1.70744661345097 2.87934212005942e-20 2.07152152023539 2.94685578585709e-08 MirTarget -0.322074263479633 0.000715997285583281 NA NA NA hsa-miR-195-5p COL24A1 -1.85907534356434 1.47434041676402e-22 2.07152152023539 2.94685578585709e-08 MirTarget;miRNATAP -0.194900929860117 0.0350158835630393 NA NA NA hsa-miR-301a-3p COL4A4 0.842910511640361 1.43446467417891e-06 -1.21297499956657 3.63510226190771e-06 mirMAP -0.173538642343536 0.0176181562335231 NA NA NA hsa-miR-195-5p COPS7B -1.85907534356434 1.47434041676402e-22 0.641973815480622 1.99581786116502e-17 MirTarget;miRNATAP -0.161452690901605 8.47727577977462e-19 NA NA NA hsa-miR-101-3p COTL1 -1.48176407980989 3.98950707385704e-31 -0.867775465859173 1.16048121305802e-06 MirTarget -0.136585338164481 0.0335468218975382 NA NA NA hsa-miR-101-3p CPA4 -1.48176407980989 3.98950707385704e-31 0.055606222876432 0.855985510169103 mirMAP -0.448190410712008 3.34967157378707e-05 NA NA NA hsa-miR-195-5p CPD -1.85907534356434 1.47434041676402e-22 0.599470550586786 4.65999718552314e-06 MirTarget;miRNATAP -0.129070855836969 5.25443368771879e-05 NA NA NA hsa-miR-301a-3p CPEB3 0.842910511640361 1.43446467417891e-06 -2.73760799365771 6.08365930201296e-43 MirTarget;miRNATAP -0.603918544654756 9.56663365803828e-26 NA NA NA hsa-miR-301a-3p CPEB4 0.842910511640361 1.43446467417891e-06 -1.06097838176943 9.01316045116939e-14 miRNATAP -0.309463338702969 2.67333920014437e-15 NA NA NA hsa-miR-195-5p CPLX1 -1.85907534356434 1.47434041676402e-22 0.817008398608116 0.00266488469970708 mirMAP -0.144167785402114 0.0299487050146352 NA NA NA hsa-miR-195-5p CPSF4 -1.85907534356434 1.47434041676402e-22 0.77988036729674 7.78075887976318e-16 mirMAP -0.196626013024372 4.59456658964273e-17 NA NA NA hsa-miR-199b-5p CRLS1 -0.454049170125872 0.254611775331658 -0.215826506189612 0.0806992664086582 miRanda;miRNATAP -0.125332582139846 2.07297162287626e-17 NA NA NA hsa-miR-199a-5p CSAG1 -1.98848462405923 2.0421622713753e-11 2.1798609633964 7.96763294890031e-05 miRanda -0.369007009512577 3.1237508030057e-05 NA NA NA hsa-miR-199b-5p CSAG1 -0.454049170125872 0.254611775331658 2.1798609633964 7.96763294890031e-05 miRanda -0.158528507648512 0.0222510488922717 NA NA NA hsa-let-7c-5p CSNK2A1 -1.70744661345097 2.87934212005942e-20 0.311613292322925 6.17228757339028e-05 miRNAWalker2_validate -0.118081213291704 8.22763425873157e-10 NA NA NA hsa-miR-199a-5p CSTF2 -1.98848462405923 2.0421622713753e-11 0.85091870857946 8.11906704717493e-17 miRanda -0.10275304862555 6.76682187320064e-10 NA NA NA hsa-miR-101-3p CTDSPL -1.48176407980989 3.98950707385704e-31 0.0757033671137659 0.487293695066413 MirTarget -0.190820768949584 5.70828321662725e-07 NA NA NA hsa-miR-199a-3p CTNNA2 -2.3279328685682 1.04468066198593e-17 2.25787302460162 0.000155826635136281 MirTarget -0.521228083201561 3.46304846039583e-07 NA NA NA hsa-miR-101-3p CTNND2 -1.48176407980989 3.98950707385704e-31 -1.18454154034261 0.0540804866207506 MirTarget -1.31750496628151 8.55034340965094e-10 NA NA NA hsa-miR-195-5p CUEDC1 -1.85907534356434 1.47434041676402e-22 0.930881262265448 8.48699763636032e-12 mirMAP -0.129784783255477 0.000121820769514115 NA NA NA hsa-miR-101-3p CUL4B -1.48176407980989 3.98950707385704e-31 0.321392957566996 8.06539050055239e-06 miRNATAP -0.107867466000864 2.35544600340916e-05 NA NA NA hsa-miR-301a-3p CXCL12 0.842910511640361 1.43446467417891e-06 -3.59146357807385 1.03718574480494e-35 miRNATAP -0.286138029073657 0.00094887575133379 NA NA NA hsa-miR-101-3p CXorf23 -1.48176407980989 3.98950707385704e-31 0.430761186308626 9.49129189428509e-06 miRNATAP -0.111470412323436 0.00132665157788313 NA NA NA hsa-let-7c-5p CYB561D1 -1.70744661345097 2.87934212005942e-20 1.35618855619484 4.53684308721849e-24 MirTarget -0.301970204704956 9.88527966067797e-19 NA NA NA hsa-miR-195-5p CYB561D1 -1.85907534356434 1.47434041676402e-22 1.35618855619484 4.53684308721849e-24 mirMAP -0.225234835940835 2.3425495484699e-11 NA NA NA hsa-miR-101-3p CYB561D2 -1.48176407980989 3.98950707385704e-31 0.340634488424108 0.000332139447654417 MirTarget -0.10465528927374 0.00193189680863732 NA NA NA hsa-miR-301a-3p CYBRD1 0.842910511640361 1.43446467417891e-06 -1.29333537908526 9.44725361000613e-10 miRNAWalker2_validate -0.176051610153848 0.00305777326556351 NA NA NA hsa-miR-301a-3p CYLD 0.842910511640361 1.43446467417891e-06 -0.423088167274311 1.00113522728174e-06 miRNATAP -0.185946629285208 1.3014646399479e-15 NA NA NA hsa-miR-301a-3p CYP2U1 0.842910511640361 1.43446467417891e-06 -1.01838808023932 3.26776270502471e-10 MirTarget -0.352161154012861 1.46743536773397e-15 NA NA NA hsa-miR-301a-3p CYP4F3 0.842910511640361 1.43446467417891e-06 -1.55307662086169 1.07679103282901e-07 mirMAP -0.607765264642622 1.94443021362135e-14 NA NA NA hsa-miR-199b-5p CYP7B1 -0.454049170125872 0.254611775331658 -1.32572773756505 1.31635852565651e-07 PITA;miRanda -0.130442980970618 3.50708513722763e-05 NA NA NA hsa-miR-301a-3p DAAM1 0.842910511640361 1.43446467417891e-06 -0.820319075229238 3.16122030911227e-05 MirTarget;miRNATAP -0.221373325761519 4.89015141234831e-05 NA NA NA hsa-let-7c-5p DAGLA -1.70744661345097 2.87934212005942e-20 1.16197262256378 7.56867119602314e-06 MirTarget -0.448159334629883 3.0762615596391e-12 NA NA NA hsa-miR-195-5p DAGLA -1.85907534356434 1.47434041676402e-22 1.16197262256378 7.56867119602314e-06 mirMAP -0.250018739914129 7.98243231451087e-05 NA NA NA hsa-let-7c-5p DCAF15 -1.70744661345097 2.87934212005942e-20 0.442903624361357 6.04251738050238e-08 MirTarget -0.101335020598812 8.14528075667905e-07 NA NA NA hsa-miR-195-5p DCAF7 -1.85907534356434 1.47434041676402e-22 0.251218863383806 0.00107426725385292 miRNATAP -0.101229827007405 3.66906143869405e-08 NA NA NA hsa-miR-199a-5p DCAF8L1 -1.98848462405923 2.0421622713753e-11 1.27929743308881 0.00128950624191721 miRanda -0.237568766095023 0.000190920544862762 NA NA NA hsa-miR-199b-5p DCAF8L1 -0.454049170125872 0.254611775331658 1.27929743308881 0.00128950624191721 miRanda -0.107937985295797 0.0300262720191963 NA NA NA hsa-let-7c-5p DCLRE1B -1.70744661345097 2.87934212005942e-20 0.715031438649862 1.3174682860474e-13 MirTarget -0.114154467810837 3.88086854753268e-06 NA NA NA hsa-miR-101-3p DCLRE1B -1.48176407980989 3.98950707385704e-31 0.715031438649862 1.3174682860474e-13 MirTarget -0.212046946084468 9.21540038854983e-10 NA NA NA hsa-miR-101-3p DCP2 -1.48176407980989 3.98950707385704e-31 0.261080000757517 0.00123409478740543 mirMAP -0.13941817335933 9.18199051199034e-07 NA NA NA hsa-let-7c-5p DCTN5 -1.70744661345097 2.87934212005942e-20 0.109069264850494 0.145747375920191 miRNAWalker2_validate -0.137050765086275 4.53587636121251e-14 NA NA NA hsa-miR-101-3p DDA1 -1.48176407980989 3.98950707385704e-31 0.436457331280509 1.13774933904213e-08 mirMAP -0.173180505387266 1.28541285571532e-10 NA NA NA hsa-miR-30d-5p DDIT4 0.718283816348023 2.47422074061352e-08 0.228443977506799 0.236844454905723 MirTarget;miRNATAP -0.20537756673444 0.00438989200660324 NA NA NA hsa-miR-32-5p DDIT4 0.0806126674664016 0.548984992497432 0.228443977506799 0.236844454905723 miRNATAP -0.199880895095326 0.00445876889151134 NA NA NA hsa-miR-618 DDIT4 0.13539895350352 0.517145913114103 0.228443977506799 0.236844454905723 mirMAP -0.103348311950453 0.0269914503772347 NA NA NA hsa-miR-92a-3p DDIT4 0.212391012518195 0.134292268089997 0.228443977506799 0.236844454905723 miRNATAP -0.182713424395714 0.00604393810305066 NA NA NA hsa-miR-195-5p DEF8 -1.85907534356434 1.47434041676402e-22 0.614076798619747 3.82744235570261e-11 MirTarget -0.148323547065453 4.74220171223074e-11 NA NA NA hsa-miR-301a-3p DENND5B 0.842910511640361 1.43446467417891e-06 -0.618139309020725 4.9388184165447e-08 mirMAP -0.138112699801713 1.1378319483404e-05 NA NA NA hsa-miR-101-3p DENR -1.48176407980989 3.98950707385704e-31 0.3542544253519 1.71077585620851e-08 MirTarget -0.204740505204873 1.21030720483275e-21 NA NA NA hsa-miR-199a-3p DEPDC1B -2.3279328685682 1.04468066198593e-17 2.81995289547286 3.64152756583752e-21 MirTarget;miRNATAP -0.200678887454134 0.000192299453302248 NA NA NA hsa-miR-199a-5p DEPDC1B -1.98848462405923 2.0421622713753e-11 2.81995289547286 3.64152756583752e-21 PITA;miRanda -0.182601071463573 0.000268581258343197 NA NA NA hsa-miR-195-5p DGKD -1.85907534356434 1.47434041676402e-22 0.711034021867333 8.46501341224824e-13 mirMAP -0.113932392119109 3.49709728174593e-06 NA NA NA hsa-miR-301a-3p DGKE 0.842910511640361 1.43446467417891e-06 -0.855065779351597 4.0361991167554e-06 MirTarget;miRNATAP -0.147959576663642 0.00418920901572187 NA NA NA hsa-miR-199b-5p DHRS12 -0.454049170125872 0.254611775331658 -0.9035226601534 3.79210429385817e-10 miRanda -0.109137534529417 1.31360357432204e-09 NA NA NA hsa-miR-199a-5p DIAPH3 -1.98848462405923 2.0421622713753e-11 3.40810304475021 2.20268130608007e-38 miRanda -0.301245249074546 2.96895582080731e-11 NA NA NA hsa-miR-101-3p DLG5 -1.48176407980989 3.98950707385704e-31 1.50511854034316 3.93408903539969e-21 MirTarget;miRNATAP -0.372419278070482 1.80114211006818e-10 NA NA NA hsa-let-7c-5p DLGAP4 -1.70744661345097 2.87934212005942e-20 0.616384781844966 4.24155614328603e-13 MirTarget -0.178146649866821 2.96101504576869e-17 NA NA NA hsa-miR-301a-3p DLL1 0.842910511640361 1.43446467417891e-06 -0.548830846531552 0.0160272291862025 miRNATAP -0.258185613691722 3.70622789079857e-05 NA NA NA hsa-miR-199a-3p DLX5 -2.3279328685682 1.04468066198593e-17 1.7796725834344 1.28017204783704e-07 PITA -0.158914950246505 0.00690203951913021 NA NA NA hsa-miR-199a-5p DMC1 -1.98848462405923 2.0421622713753e-11 1.604843560386 2.15396053628869e-08 miRanda -0.100730617569996 0.0311482011828312 NA NA NA hsa-miR-199b-5p DMD -0.454049170125872 0.254611775331658 -1.6618166260325 2.70344741582688e-17 miRanda -0.111877411449954 9.33937244156211e-06 NA NA NA hsa-miR-199a-5p DNAH1 -1.98848462405923 2.0421622713753e-11 0.726489022704404 3.75864175578582e-05 miRanda -0.10328197119177 0.000266719418826918 NA NA NA hsa-miR-301a-3p DNAJC16 0.842910511640361 1.43446467417891e-06 -0.708396806607303 1.19570148646952e-16 MirTarget -0.118586784085238 9.29460690154445e-07 NA NA NA hsa-let-7c-5p DNAJC6 -1.70744661345097 2.87934212005942e-20 2.31761593888368 5.40782208875271e-21 miRNAWalker2_validate -0.383639320555159 2.04522452132374e-09 NA NA NA hsa-miR-101-3p DNM1L -1.48176407980989 3.98950707385704e-31 0.461545461792854 3.707783316895e-10 MirTarget -0.200208712366628 7.60513791841845e-15 NA NA NA hsa-miR-101-3p DNMT3A -1.48176407980989 3.98950707385704e-31 1.18820126942617 6.93286101815213e-19 miRNAWalker2_validate;MirTarget;miRNATAP -0.519122138021994 4.03558002699037e-29 26927545;25210796 The expressions of miR-101 and DNA methyltransferase 3a DNMT3a in breast cancer tissues corresponding normal breast tissues breast cancer cells and normal breast cells were detected by real-time quantitative PCR; The lentiviral vectors containing miR-101 and shRNA-DNMT3a sequences were transfected into MDA-MB-231 cells to regulate the expressions of miR-101 and DNMT3a; Breast cancer tissues and breast cancer cell lines MCF-7 MDA-MB-231 MDA-MB-361 HCC70 showed lower miR-101 expression and higher DNMT3a expression than the adjacent normal breast tissues and normal breast cell line; The overexpression of miR-101 resulted in downregulation of DNMT3a and restoration of E-cadherin; miR-101 may inhibit MDA-MB-231 cell proliferation and migration by repressing DNMT3a expression and up-regulating E-cadherin expression;Restoration of miR 101 suppresses lung tumorigenesis through inhibition of DNMT3a dependent DNA methylation; The deregulation of miR-101 and DNMT3a has been implicated in the pathogenesis of multiple tumor types but whether and how miR-101 silencing and DNMT3a overexpression contribute to lung tumorigenesis remain elusive; Here we show that miR-101 downregulation associates with DNMT3a overexpression in lung cancer cell lines and patient tissues; Functionally restoration of miR-101 expression suppressed lung cancer cell clonability and migration which recapitulated the DNMT3a knockdown effects; Interestingly miR-101 synergized with decitabine to downregulate DNMT3a and to reduce DNA methylation; Consistent with these phenotypes examination of xenograft tumors disclosed an increase of miR-101 a decrease of DNMT3a and the subsequent DNA demethylation ;tumorigenesis breast cancer;lung cancer hsa-miR-199a-3p DNMT3A -2.3279328685682 1.04468066198593e-17 1.18820126942617 6.93286101815213e-19 MirTarget;PITA;miRNATAP -0.128565104280402 5.98009906284426e-08 NA NA NA hsa-let-7c-5p DOT1L -1.70744661345097 2.87934212005942e-20 0.585703387018246 2.71031330751421e-07 miRNAWalker2_validate -0.149931329292625 1.58114052310453e-07 NA NA NA hsa-miR-101-3p DOT1L -1.48176407980989 3.98950707385704e-31 0.585703387018246 2.71031330751421e-07 MirTarget -0.181696936223352 7.75453234640001e-06 NA NA NA hsa-miR-195-5p DPH3 -1.85907534356434 1.47434041676402e-22 0.156886414904455 0.0299394459953927 MirTarget -0.102559369092243 2.30111618178579e-09 NA NA NA hsa-miR-301a-3p DPYSL2 0.842910511640361 1.43446467417891e-06 -0.459626007194783 0.000892653964210093 MirTarget;miRNATAP -0.123871327590015 0.00118964783411314 NA NA NA hsa-miR-101-3p DSTYK -1.48176407980989 3.98950707385704e-31 1.00504202460505 2.41375496861128e-19 miRNATAP -0.370523773851966 7.46879868841295e-21 NA NA NA hsa-miR-199a-3p DTNA -2.3279328685682 1.04468066198593e-17 1.85440917822318 1.2434230849807e-10 PITA;miRNATAP -0.105155567629189 0.0384704269797366 NA NA NA hsa-miR-199a-5p DUT -1.98848462405923 2.0421622713753e-11 0.667194225934214 2.95656316745994e-10 miRanda -0.104507362977727 7.25530834539428e-10 NA NA NA hsa-miR-195-5p DYNC1I1 -1.85907534356434 1.47434041676402e-22 1.66864494169359 1.46552904583527e-05 MirTarget;miRNATAP -0.450441231652987 1.47307930884972e-06 NA NA NA hsa-miR-301a-3p DYNLL2 0.842910511640361 1.43446467417891e-06 -0.626535692486098 7.86372375431067e-08 MirTarget -0.159240301362909 8.08676301878422e-07 NA NA NA hsa-miR-195-5p DYRK1B -1.85907534356434 1.47434041676402e-22 0.432980103635144 0.000665367161987308 MirTarget;miRNATAP -0.121152456774491 8.63484344707719e-05 NA NA NA hsa-let-7c-5p DZIP1L -1.70744661345097 2.87934212005942e-20 -0.0817102374066513 0.728597088782924 MirTarget -0.153365860262585 0.00940939013868638 NA NA NA hsa-let-7c-5p E2F2 -1.70744661345097 2.87934212005942e-20 2.82262179260901 6.90997126839698e-33 MirTarget -0.605641654221748 3.1290897462579e-23 NA NA NA hsa-miR-101-3p E2F3 -1.48176407980989 3.98950707385704e-31 0.679179223655044 3.98775697474768e-07 miRNAWalker2_validate -0.408210251322335 1.00202902205119e-18 NA NA NA hsa-miR-195-5p E2F3 -1.85907534356434 1.47434041676402e-22 0.679179223655044 3.98775697474768e-07 miRNAWalker2_validate;miRTarBase;miRNATAP -0.115038038576163 0.000460113206577871 22217655 We identified E2F3 and CCND3 as functional downstream targets of miR-195 in glioblastoma cells glioblastoma hsa-let-7c-5p E2F5 -1.70744661345097 2.87934212005942e-20 0.730554652437087 0.000401890915871585 MirTarget -0.228095461415917 1.04748751614991e-05 NA NA NA hsa-miR-195-5p E2F7 -1.85907534356434 1.47434041676402e-22 3.06815276582178 3.19808997821633e-30 miRNATAP -0.366097144828542 1.33633606432699e-07 NA NA NA hsa-miR-101-3p E2F8 -1.48176407980989 3.98950707385704e-31 3.82257627150129 4.96698856709543e-39 miRNATAP -0.92382497640047 5.58947557693746e-17 NA NA NA hsa-miR-101-3p EBF1 -1.48176407980989 3.98950707385704e-31 1.93068987874298 7.85878306597582e-25 miRNATAP -0.417797093062148 1.90514649737457e-09 NA NA NA hsa-miR-199a-5p EBP -1.98848462405923 2.0421622713753e-11 -0.537796123669657 0.00102316402969725 miRanda -0.104033247677974 7.07776090619497e-05 NA NA NA hsa-miR-199b-5p EBP -0.454049170125872 0.254611775331658 -0.537796123669657 0.00102316402969725 miRanda -0.112938740603972 2.09182091197643e-08 NA NA NA hsa-miR-199a-5p EDARADD -1.98848462405923 2.0421622713753e-11 0.941526304158294 3.91500041594882e-05 MirTarget;miRanda -0.104085075472553 0.00482995523774161 NA NA NA hsa-miR-301a-3p EDEM1 0.842910511640361 1.43446467417891e-06 -0.854125196107966 8.48935244483275e-15 MirTarget;mirMAP -0.289698524798373 2.12903695054418e-22 NA NA NA hsa-miR-301a-3p EDN1 0.842910511640361 1.43446467417891e-06 -0.965661923166048 5.20602087013405e-06 MirTarget -0.147339771073047 0.0126681142385856 NA NA NA hsa-miR-101-3p EED -1.48176407980989 3.98950707385704e-31 0.570431696770329 3.87407211322809e-15 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.19869054659094 1.13006887905929e-14 24002871 miR-101 in turn inhibits the expression of two subunits of PRC2 EZH2 and EED thus creating a double-negative feedback loop that regulates the process of hepatocarcinogenesis tumorigenesis liver cancer hsa-miR-101-3p EFNA5 -1.48176407980989 3.98950707385704e-31 -1.35514027226431 0.000692469246595569 miRNATAP -0.628698296210383 9.0433663712587e-06 NA NA NA hsa-miR-301a-3p EFNB2 0.842910511640361 1.43446467417891e-06 0.0997333215214327 0.477026029683948 miRNATAP -0.14580670889497 0.000147161258983717 NA NA NA hsa-miR-301a-3p EFR3A 0.842910511640361 1.43446467417891e-06 -0.119153209175691 0.320887144206676 MirTarget -0.17880177655112 3.96954220778649e-08 NA NA NA hsa-miR-330-5p EIF4B 0.442231058604099 0.0053308560843808 -0.213371036122907 0.00927846005206924 miRNATAP -0.121583930567148 1.00720259566484e-06 NA NA NA hsa-miR-339-5p EIF4B 0.280589919878422 0.0355660282647215 -0.213371036122907 0.00927846005206924 miRanda -0.131202132226587 1.04386561466155e-05 NA NA NA hsa-miR-342-3p EIF4B -0.319677314984262 0.0449813878317147 -0.213371036122907 0.00927846005206924 miRanda -0.127381134711691 2.69280086896855e-07 NA NA NA hsa-miR-362-3p EIF4B 0.814007335895913 2.00108618836568e-09 -0.213371036122907 0.00927846005206924 miRanda -0.120133065959791 2.94856447934838e-05 NA NA NA hsa-miR-484 EIF4B 0.0857240033709656 0.453982056282229 -0.213371036122907 0.00927846005206924 miRNAWalker2_validate -0.156463221852403 7.2363961844545e-06 NA NA NA hsa-miR-497-5p EIF4B -1.41371173021948 7.09278946477743e-17 -0.213371036122907 0.00927846005206924 miRNATAP -0.103808529523177 3.87646612451936e-06 NA NA NA hsa-miR-107 EIF4E 0.241662461253461 0.0170788899505389 -0.423618150345152 8.76394952666589e-09 miRanda -0.145690630779375 5.10144854982989e-05 NA NA NA hsa-miR-25-3p EIF4E 0.633062563556379 3.68686354834328e-10 -0.423618150345152 8.76394952666589e-09 mirMAP -0.120897171896447 0.000649613904023936 NA NA NA hsa-miR-500a-3p EIF4E 1.18913245435489 1.59516890341346e-16 -0.423618150345152 8.76394952666589e-09 MirTarget -0.100990657027664 2.96319587641026e-05 NA NA NA hsa-miR-660-5p EIF4E 0.989755850734071 5.69930767464937e-14 -0.423618150345152 8.76394952666589e-09 mirMAP -0.155553210664168 3.85299588654816e-09 NA NA NA hsa-miR-140-5p EIF4E2 -0.220106443070144 0.0140713197101242 -0.0307165992319307 0.660560144350934 miRanda -0.138995836241305 0.000258086393762208 NA NA NA hsa-miR-29a-3p EIF4E2 -0.856762511178136 4.65330336378459e-12 -0.0307165992319307 0.660560144350934 MirTarget -0.113597041826362 1.87271499311999e-05 NA NA NA hsa-miR-125b-5p EIF4EBP1 -1.35767721102906 1.16564617395164e-18 -0.0296151122465442 0.838078981735608 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.116832363024321 0.00778246256108478 17891175;26646586 Using a bioinformatics approach we have identified additional potential mRNA targets of one of the miRNAs miR-125b that are upregulated in prostate cancer and confirmed increased expression of one of these targets EIF4EBP1 in prostate cancer tissues;Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ; prostate cancer;ovarian cancer hsa-let-7c-5p ELF4 -1.70744661345097 2.87934212005942e-20 -0.129534848954421 0.489734019401336 MirTarget -0.135890153838811 0.0038215332500121 NA NA NA hsa-miR-101-3p ELFN2 -1.48176407980989 3.98950707385704e-31 2.86706730299717 2.25493376503085e-09 miRNATAP -0.75201790285914 1.31705058415851e-05 NA NA NA hsa-miR-301a-3p ELK3 0.842910511640361 1.43446467417891e-06 -0.374593711821051 0.0677288387929772 MirTarget;miRNATAP -0.178855821338702 0.00153569721316385 NA NA NA hsa-miR-301a-3p ELL2 0.842910511640361 1.43446467417891e-06 -0.765981836031949 3.63519932659754e-07 MirTarget -0.192768893740431 3.79545508045073e-06 NA NA NA hsa-miR-195-5p ENAH -1.85907534356434 1.47434041676402e-22 1.39629433723863 3.42757488063496e-20 MirTarget;miRNATAP -0.19079847273158 5.97429395289528e-07 NA NA NA hsa-miR-301a-3p ENDOD1 0.842910511640361 1.43446467417891e-06 -0.998600185815336 9.70620010845927e-08 MirTarget -0.133493833239928 0.0109120853634808 NA NA NA hsa-miR-199b-5p ENPP1 -0.454049170125872 0.254611775331658 -1.11112717299379 2.16026245265541e-12 miRanda -0.115199390091119 6.9605729853954e-09 NA NA NA hsa-miR-101-3p ENY2 -1.48176407980989 3.98950707385704e-31 0.370401379899691 0.0028974742243566 MirTarget -0.137681904683709 0.00183711050464044 NA NA NA hsa-miR-101-3p EPB41L1 -1.48176407980989 3.98950707385704e-31 0.134154503301847 0.605658196491617 miRNATAP -0.402258972919121 1.10428244385054e-05 NA NA NA hsa-miR-301a-3p EPHA4 0.842910511640361 1.43446467417891e-06 -0.0136675398232678 0.946218625851897 mirMAP -0.280082339386263 3.8129879165648e-07 NA NA NA hsa-miR-301a-3p EPS15 0.842910511640361 1.43446467417891e-06 -0.299266773136494 8.77908615019208e-06 MirTarget;miRNATAP -0.101693237194067 3.02446076535706e-08 NA NA NA hsa-miR-301a-3p ERCC4 0.842910511640361 1.43446467417891e-06 -0.398490625556519 0.000316330847829454 MirTarget -0.19966478041548 2.64477294609948e-11 NA NA NA hsa-miR-301a-3p ERLIN2 0.842910511640361 1.43446467417891e-06 -0.765814822219247 2.25238859952501e-10 mirMAP -0.2213508382503 2.75080479109118e-11 NA NA NA hsa-let-7c-5p ESPL1 -1.70744661345097 2.87934212005942e-20 1.87757313624794 3.45937181689806e-13 MirTarget -0.45417008213531 3.14084416633658e-12 NA NA NA hsa-miR-199b-5p ESPN -0.454049170125872 0.254611775331658 -0.816007488864041 0.000566995681314034 miRanda -0.100881626299942 0.000631559139588505 NA NA NA hsa-miR-301a-3p ESR1 0.842910511640361 1.43446467417891e-06 -4.11885094897542 1.63160126578307e-28 miRNATAP -0.963716192837529 4.91761715225445e-20 NA NA NA hsa-miR-101-3p ETV5 -1.48176407980989 3.98950707385704e-31 -0.145389102256725 0.355370993767523 MirTarget;miRNATAP -0.300492094353644 4.72780586267988e-08 NA NA NA hsa-miR-301a-3p EVI5 0.842910511640361 1.43446467417891e-06 -0.656558367861793 2.14847579134138e-11 mirMAP -0.119036747434174 1.44595120360695e-05 NA NA NA hsa-miR-101-3p EZH2 -1.48176407980989 3.98950707385704e-31 2.56936752791081 3.12233537592977e-46 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.759013473060081 6.28053761420465e-30 24002871;26718325;24211739;26251675;22108826;24490857;23962556;21818714;25260883;25428391;27620004;22450781;25400732;25190211;22977606;24807198;21321380;22094936;21270667 miR-101 in turn inhibits the expression of two subunits of PRC2 EZH2 and EED thus creating a double-negative feedback loop that regulates the process of hepatocarcinogenesis; In addition co-overexpression of c-Myc and EZH2 in HCC samples was closely associated with lower expression of miR-101 P < 0.0001 and poorer prognosis of HCC patients P < 0.01;Reporter gene assays revealed that ectopic expression of EZH2 inhibited the transcriptional activities of miR-101-1 promoter; Moreover our results also demonstrated that similar antitumor effects can be achieved either by ectopic miR-101 or EZH2 silencing in HCC cells; These findings show that elevated EZH2 contributes to miR-101 deregulation in HCC and highlight the coordinated role of miR-101 and EZH2 in hepatocarcinogenesis;The aim of our study was to investigate the functional role of both miR-101 and EZH2 in human hepatocellular carcinoma HCC; MiR-101 and EZH2 expressions were evaluated in tumor tissues of 99 HCC patients and 7 liver cancer cell lines by real-time PCR; Luciferase reporter assay was employed to validate whether EZH2 represents a target gene of miR-101; MiR-101 expression was significantly downregulated in most of HCC tissues and all cell lines whereas EZH2 was significantly overexpressed in most of HCC tissues and all cell lines; There was a negative correlation between expression levels of miR-101 and EZH2; Luciferase assay results confirmed EZH2 as a direct target gene of miR-101 which negatively regulates EZH2 expression in HCC; Tumor suppressor miR-101 represses HCC progression through directly targeting EZH2 oncogene and sensitizes liver cancer cells to chemotherapeutic treatment;MiR-101 is a microRNA involved in a negative feedback circuit with EZH2 in different normal and tumor tissues; To that miR-101 can behave as a tumor suppressor in several cancers by repressing EZH2 expression; We therefore evaluated whether miR-101 is de-regulated in eRMS and investigated its interplaying with EZH2 as well as its role in the in vitro tumorigenic potential of these tumor cells; Herein we report that miR-101 is down-regulated in eRMS patients and in tumor cell lines compared to their controls showing an inverse pattern of expression with EZH2; We also show that miR-101 is up-regulated in eRMS cells following both genetic and pharmacological inhibition of EZH2; In turn miR-101 forced expression reduces EZH2 levels as well as restrains the migratory potential of eRMS cells and impairs their clonogenic and anchorage-independent growth capabilities; This phenomenon is associated to reduced H3K27me3 levels at the same regulatory locus indicating that EZH2 directly targets miR-101 for repression in eRMS cells; Altogether our data show that in human eRMS miR-101 is involved in a negative feedback loop with EZH2 whose targeting has been previously shown to halt eRMS tumorigenicity;Mechanistic investigations revealed that reexpression of miR-101 was sufficient to limit the expression of EZH2 and the proinvasive cell surface adhesion molecule EpCAM;Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid induced apoptosis through down regulation of EZH2 expression by miR 101; Furthermore treatment of bladder cancer cells with a combination of GA and MJ induced synergistic inhibition of the enhancer of zeste homologue 2 EZH2 expression whereas miR-101 expression was up-regulated; Conversely knockdown of miR-101 restored this decreased expression of EZH2 and suppressed the inhibitory effect of GA and MJ on the growth of bladder cancer cells; MJ sensitizes bladder cancer cells to GA-induced apoptosis by down-regulating the expression of EZH2 induced by miR-101;MiR 101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2; Functional assays showed that miR-101 suppressed invasion and proliferation - an outcome that could be phenocopied by siRNA knockdown of MITF and EZH2;We explore the role of miR-101 and its interaction with EzH2 in epithelial ovarian carcinoma EOC; CHIP assays revealed that re-expression of miR-101 inhibited the interaction of EzH2 with p21waf1/cip1 promoter;miR 101 regulates expression of EZH2 and contributes to progression of and cisplatin resistance in epithelial ovarian cancer; miR-101 overexpression decreased the expression of EZH2 reduced proliferation and migration of ovarian cancer cells and resensitized drug-resistant cancer cells to cisplatin-induced cytotoxicity suggesting the important role miR-101 plays in ovarian cancer that may be associated with its function as a regulator targeting EZH2;The results showed that mir-101 was down-regulated and EZH2 were upregulated; Subsequently the roles of mir-101 and EZH2 in tumor growth and progression in vitro were tested; Overexpression of mir-101 mimics was able to suppress the expression of EZH2 in XWLC-05 cells; Interleukin-1β subsequently induces the downregulation of mir-101 which may result in the upregulated level of EZH2 and occurrence of lung cancer;Long non coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR 101 to modulate EZH2 expression;Moreover around 40% of cases showing miR-101 down-regulation displayed concomitant EZH2 over-expression at the RNA and protein levels which in turn was associated with loss/aberrant expression of E-cadherin; In conclusion we show that deletions and/or microdeletions at both miR-101 genomic loci cause mature miR-101 down-regulation subsequent EZH2 over-expression and E-cadherin dysfunction specifically in intestinal-type GC;miR 101 suppresses tumor proliferation and migration and induces apoptosis by targeting EZH2 in esophageal cancer cells; The expression level of miR-101 was inversely correlated to EZH2 protein expression in ESCC cell; These findings suggest that decreased expression of miR-101 might promote metastasis of human ESCC by inducing accumulation of EZH2 protein;In the present study we reported that ectopic overexpression of miR-101 downregulated the expression level of EZH2 and significantly inhibited migration and invasion of osteosarcoma cells; In addition knockdown of EZH2 by siRNA showed the same effect of miR-101 on migration and invasion; To conclude these results indicate that miR-101 may act as a tumor suppressor in osteosarcoma as it has a suppressive role in cell migration and invasion by targeting EZH2;Therefore we aimed to ascertain whether or not the overexpression of miR-101 inhibits invasion of lung cancer through regulation of EZH2; In this study the expression of miR-101 was down-regulated and the expression of EZH2 was up-regulated in lung cancer; Overexpression of miR-101 induced a marked reduction in EZH2 mRNA levels in several lung cancer cell lines; miR-101 may be a potent tumor suppressor by altering chromatin structure through repression of EZH2 and may be a potential therapeutic tool for patients with lung cancer;MiR 101 downregulated in retinoblastoma functions as a tumor suppressor in human retinoblastoma cells by targeting EZH2; Finally we found that miR-101 directly inhibited EZH2 expression by targeting its 3'-UTR and EZH2 was upregulated and inversely correlated with miR-101 expression in the retinoblastoma tissues; Thus for the first time we provide convincing evidence that downregulation of miR-101 is associated with tumor aggressiveness in retinoblastoma and inhibits cell growth and proliferation of retinoblastoma cells by targeting EZH2;miR 101 is down regulated in glioblastoma resulting in EZH2 induced proliferation migration and angiogenesis; Here we determined that miR-101 is down-regulated in GBM resulting in overexpression of the miR-101 target PcG protein EZH2 a histone methyltransferase affecting gene expression profiles in an epigenetic manner; Our results indicate that EZH2 has a versatile function in GBM progression and that its overexpression is at least partly due to decreased miR-101 expression;Main objective of the present study is to investigate miR-26a and miR-101 levels which both target EZH2 for their association with molecular pathways and with efficacy of tamoxifen as first-line monotherapy for metastatic breast cancer;In this study we investigate whether miRNA miR-101 regulates EZH2 expression in NSCLC; We evaluated the expression of miR-101 and EZH2 in 20 matched NSCLC and adjacent nontumor lung tissues by reverse-transcriptase polymerase chain reaction and immunohistochemistry respectively; Luciferase reporter assay was used to determine whether miR-101 directly targets EZH2; To assess the effect of miR-101 on NSCLC biological behavior cell proliferation invasion and response to chemotherapy were analyzed using NSCLC cells transfected with miR-101 mimics or transfected with specific small interfering RNA to deplete EZH2 small interfering RNA-EZH2; Reduced expression of miR-101 was associated with overexpression of EZH2 in NSCLC tumor tissues; Transfection of miR-101 mimics significantly suppressed the activity of the luciferase reporter containing wild type but not mutant EZH2 3'-UTR and decreased EZH2 expression in NSCLC cell lines; Therapeutic strategies to rescue miR-101 expression or silence EZH2 may be beneficial to patients with NSCLC in the future tumorigenesis;worse prognosis;tumorigenesis;progression;;;;;;progression;drug resistance;progression;progression;;metastasis;cell migration;;;progression;;drug resistance liver cancer;liver cancer;liver cancer;sarcoma;pancreatic cancer;bladder cancer;melanoma;ovarian cancer;ovarian cancer;lung cancer;gastric cancer;gastric cancer;esophageal cancer;sarcoma;lung cancer;retinoblastoma;glioblastoma;breast cancer;lung squamous cell cancer hsa-miR-199a-5p EZH2 -1.98848462405923 2.0421622713753e-11 2.56936752791081 3.12233537592977e-46 miRNAWalker2_validate -0.20459098581409 1.02535117313981e-10 NA NA NA hsa-miR-199b-5p F5 -0.454049170125872 0.254611775331658 -0.326925679296005 0.130648550867534 miRanda -0.153570374670392 6.49505720599145e-09 NA NA NA hsa-miR-199b-5p F7 -0.454049170125872 0.254611775331658 -1.19466394039985 5.1916868533882e-06 miRanda -0.159710276373759 9.8192958694084e-07 NA NA NA hsa-miR-101-3p FA2H -1.48176407980989 3.98950707385704e-31 -1.26435011606672 0.00271055986812812 MirTarget -0.788302548531329 1.1116882161997e-07 NA NA NA hsa-miR-301a-3p FAHD2A 0.842910511640361 1.43446467417891e-06 -1.40674228735037 2.20738299627602e-25 mirMAP -0.354294845657873 6.21613984073462e-21 NA NA NA hsa-let-7c-5p FAM103A1 -1.70744661345097 2.87934212005942e-20 0.489844961593656 1.4777880039426e-09 miRNAWalker2_validate -0.146424524120768 3.23230414839587e-13 NA NA NA hsa-let-7c-5p FAM104A -1.70744661345097 2.87934212005942e-20 0.382548867340036 2.14628142056169e-09 MirTarget -0.10225823892978 1.28559987604419e-10 NA NA NA hsa-miR-195-5p FAM134A -1.85907534356434 1.47434041676402e-22 0.31241986271071 6.33121602143484e-06 MirTarget;miRNATAP -0.109672048010469 2.9735961244477e-11 NA NA NA hsa-miR-199a-5p FAM184A -1.98848462405923 2.0421622713753e-11 -0.0143574235908157 0.956617794277901 miRanda -0.213819699966142 2.93376457561728e-07 NA NA NA hsa-miR-199b-5p FAM184A -0.454049170125872 0.254611775331658 -0.0143574235908157 0.956617794277901 miRanda -0.214323398640911 2.26133849593361e-11 NA NA NA hsa-miR-195-5p FAM189B -1.85907534356434 1.47434041676402e-22 1.62789174379617 1.26504324091981e-42 miRNATAP -0.287830495806665 4.78404859345821e-21 NA NA NA hsa-miR-101-3p FAM53B -1.48176407980989 3.98950707385704e-31 0.971989850032648 4.87327424473216e-17 MirTarget -0.347167241695754 3.31471041965759e-17 NA NA NA hsa-miR-101-3p FAM60A -1.48176407980989 3.98950707385704e-31 0.192304077099517 0.226575212179834 MirTarget;miRNATAP -0.384841501613861 2.66570818650226e-12 NA NA NA hsa-miR-195-5p FAM60A -1.85907534356434 1.47434041676402e-22 0.192304077099517 0.226575212179834 miRNATAP -0.11911066314655 0.00198085811492019 NA NA NA hsa-miR-101-3p FAM78A -1.48176407980989 3.98950707385704e-31 0.0903525081525882 0.529997378795919 MirTarget;miRNATAP -0.148248975765043 0.00360936445739478 NA NA NA hsa-miR-101-3p FAM84A -1.48176407980989 3.98950707385704e-31 -0.723356530666459 0.00318529570176841 miRNATAP -0.186453550387221 0.0332533638353297 NA NA NA hsa-miR-199a-5p FANCA -1.98848462405923 2.0421622713753e-11 1.2099689861293 1.36777051245759e-15 PITA;miRanda;miRNATAP -0.140400005963284 1.38075478071316e-08 NA NA NA hsa-miR-199a-5p FANCD2 -1.98848462405923 2.0421622713753e-11 2.42525506695471 5.51548958189464e-31 miRanda -0.204637516440711 9.3304277040999e-09 NA NA NA hsa-let-7c-5p FANCI -1.70744661345097 2.87934212005942e-20 2.58883645204084 1.64497704333454e-42 miRNAWalker2_validate -0.553264627084958 3.44910425383123e-29 NA NA NA hsa-miR-101-3p FAR1 -1.48176407980989 3.98950707385704e-31 -0.280233283195839 0.0657019089165307 miRNAWalker2_validate;MirTarget -0.143752139028154 0.00783547075668603 NA NA NA hsa-miR-195-5p FASN -1.85907534356434 1.47434041676402e-22 0.950044385482027 2.27190916019197e-06 MirTarget -0.237846223740573 1.14174564451885e-06 23162665 microRNA 195 suppresses osteosarcoma cell invasion and migration in vitro by targeting FASN; We also identified that FASN may be a direct target of miR-195 by the luciferase activity assay sarcoma hsa-miR-101-3p FBN2 -1.48176407980989 3.98950707385704e-31 -0.531785057821196 0.0369269139070016 miRNAWalker2_validate;MirTarget;miRNATAP -0.276134853502378 0.00228249349897151 NA NA NA hsa-miR-301a-3p FBXO28 0.842910511640361 1.43446467417891e-06 -0.503712735174914 1.26784281427187e-10 MirTarget;miRNATAP -0.110602307032505 3.63551950378576e-07 NA NA NA hsa-miR-101-3p FBXO32 -1.48176407980989 3.98950707385704e-31 1.49973264070402 1.35888111194844e-11 miRNATAP -0.457433236880843 8.98934153612009e-09 NA NA NA hsa-miR-199a-5p FEN1 -1.98848462405923 2.0421622713753e-11 1.51032173359862 2.85003232854286e-30 miRanda -0.150016520844161 1.51171624324245e-11 NA NA NA hsa-miR-301a-3p FGD4 0.842910511640361 1.43446467417891e-06 -1.15544171645474 1.45947973849956e-12 mirMAP -0.369072184719178 1.3201084294401e-16 NA NA NA hsa-miR-199b-5p FGFBP2 -0.454049170125872 0.254611775331658 -1.13463853773722 4.9289735142252e-06 miRanda -0.104281863596651 0.000814252778693615 NA NA NA hsa-let-7c-5p FIGNL2 -1.70744661345097 2.87934212005942e-20 1.38863525177439 4.36348606427085e-07 MirTarget -0.440097760520244 1.38345498901364e-10 NA NA NA hsa-let-7c-5p FKBP10 -1.70744661345097 2.87934212005942e-20 0.164171258069953 0.48719948726372 miRNAWalker2_validate -0.199648875231396 0.00073149848136377 NA NA NA hsa-miR-199a-5p FKBP11 -1.98848462405923 2.0421622713753e-11 0.692833026339402 1.72381641369757e-05 miRanda -0.106821355213206 3.63938532732264e-05 NA NA NA hsa-miR-101-3p FMNL3 -1.48176407980989 3.98950707385704e-31 0.665131482558671 1.67762417764945e-07 MirTarget -0.328677859476456 1.48275140137456e-13 NA NA NA hsa-miR-199b-5p FMO5 -0.454049170125872 0.254611775331658 -1.17699610077809 1.81211211325793e-06 miRanda -0.138259645342401 7.10830923068241e-06 NA NA NA hsa-miR-301a-3p FNDC4 0.842910511640361 1.43446467417891e-06 -1.57533536587256 2.82478215784996e-11 miRNATAP -0.348498198126296 1.3382157893016e-07 NA NA NA hsa-miR-199a-3p FOXA2 -2.3279328685682 1.04468066198593e-17 -0.38624907420399 0.0461249144404801 PITA -0.166783302519726 4.15903716073793e-07 NA NA NA hsa-miR-301a-3p FRMD6 0.842910511640361 1.43446467417891e-06 -1.21152640864769 5.47511255884304e-11 MirTarget -0.102975477089075 0.0488000611485382 NA NA NA hsa-miR-199a-5p FSTL4 -1.98848462405923 2.0421622713753e-11 3.14060414756178 7.65786604995946e-16 PITA;miRanda;miRNATAP -0.220394928229541 0.000639252010971521 NA NA NA hsa-miR-199a-5p FTSJ3 -1.98848462405923 2.0421622713753e-11 0.569572494239835 3.92519030640284e-13 miRanda -0.102991898530821 1.04072656811429e-16 NA NA NA hsa-miR-101-3p FUCA2 -1.48176407980989 3.98950707385704e-31 0.0869182957071164 0.416122429650749 MirTarget -0.183424911204033 9.65997183359379e-07 NA NA NA hsa-miR-301a-3p FZD4 0.842910511640361 1.43446467417891e-06 -0.346477770504521 0.0109747315056824 mirMAP -0.250733852712318 8.69861743307876e-12 NA NA NA hsa-miR-101-3p FZD6 -1.48176407980989 3.98950707385704e-31 0.589500198001939 0.00374127878510925 miRNAWalker2_validate;MirTarget -0.312670748498135 1.38907823475328e-05 NA NA NA hsa-miR-301a-3p G0S2 0.842910511640361 1.43446467417891e-06 -2.07670656507786 2.38871174750404e-11 MirTarget -0.365217280331962 2.91422109746947e-05 NA NA NA hsa-miR-301a-3p G3BP2 0.842910511640361 1.43446467417891e-06 -0.452515291133634 1.38574303203514e-07 miRNATAP -0.116108268422001 9.68385796770978e-07 NA NA NA hsa-miR-195-5p G6PD -1.85907534356434 1.47434041676402e-22 1.94792702592171 1.26584087073773e-18 MirTarget -0.432710496904952 1.56373731213227e-15 NA NA NA hsa-miR-301a-3p GADD45A 0.842910511640361 1.43446467417891e-06 -1.18438355981419 2.04421074395418e-12 MirTarget;miRNATAP -0.429003570363722 3.99121895415153e-21 NA NA NA hsa-let-7c-5p GARS -1.70744661345097 2.87934212005942e-20 0.53606930447414 1.66438816977997e-09 miRNAWalker2_validate -0.161680244524281 2.42584352025334e-13 NA NA NA hsa-miR-199b-5p GATM -0.454049170125872 0.254611775331658 -1.67872610104551 6.33871234809562e-13 miRanda -0.116067136109464 9.45310326540401e-05 NA NA NA hsa-miR-301a-3p GBP4 0.842910511640361 1.43446467417891e-06 -0.650160615796805 0.000187737985372556 mirMAP -0.239904391087669 5.14892706810794e-07 NA NA NA hsa-miR-301a-3p GCLM 0.842910511640361 1.43446467417891e-06 -0.490472345051649 0.00239558983173471 mirMAP -0.258462766750631 4.13024761421879e-09 NA NA NA hsa-miR-101-3p GCNT3 -1.48176407980989 3.98950707385704e-31 1.91162686415997 1.25454825617439e-05 MirTarget -1.41365473570259 3.50762774469337e-21 NA NA NA hsa-miR-301a-3p GDA 0.842910511640361 1.43446467417891e-06 -1.84723490700582 3.83899286012136e-06 miRNATAP -0.684963339326644 3.87698667272729e-10 NA NA NA hsa-miR-301a-3p GFOD1 0.842910511640361 1.43446467417891e-06 -0.739136473829968 1.54144336609472e-06 mirMAP -0.287556795804095 6.64853763616607e-12 NA NA NA hsa-miR-101-3p GFPT2 -1.48176407980989 3.98950707385704e-31 -1.12444193256749 0.00225668167232903 miRNAWalker2_validate -0.548270602324454 2.66438050822188e-05 NA NA NA hsa-let-7c-5p GGA3 -1.70744661345097 2.87934212005942e-20 0.711679336404982 1.46861146142528e-21 MirTarget -0.172818653690179 3.02949988341581e-20 NA NA NA hsa-miR-195-5p GGA3 -1.85907534356434 1.47434041676402e-22 0.711679336404982 1.46861146142528e-21 MirTarget;miRNATAP -0.175712923038618 1.89310020702002e-22 NA NA NA hsa-miR-101-3p GLTSCR1 -1.48176407980989 3.98950707385704e-31 0.590565941379796 1.50384175965493e-14 MirTarget;miRNATAP -0.122510233065009 1.09609259741757e-05 NA NA NA hsa-miR-199a-5p GLUL -1.98848462405923 2.0421622713753e-11 0.444046234271983 0.126185814713881 miRanda -0.267182136488759 5.13665301435374e-09 NA NA NA hsa-miR-199b-5p GLUL -0.454049170125872 0.254611775331658 0.444046234271983 0.126185814713881 miRanda -0.24716680696271 2.22911000545924e-12 NA NA NA hsa-miR-199a-3p GLYCTK -2.3279328685682 1.04468066198593e-17 -1.01640934546018 1.04866824354547e-07 mirMAP -0.120590735558553 0.000285021173591997 NA NA NA hsa-miR-199a-5p GLYCTK -1.98848462405923 2.0421622713753e-11 -1.01640934546018 1.04866824354547e-07 miRanda -0.100264958797613 0.00121220001857005 NA NA NA hsa-miR-199b-5p GLYCTK -0.454049170125872 0.254611775331658 -1.01640934546018 1.04866824354547e-07 miRanda -0.165321863147873 2.09391119241459e-12 NA NA NA hsa-miR-101-3p GMEB2 -1.48176407980989 3.98950707385704e-31 0.649674999709834 6.33331854886269e-19 miRNAWalker2_validate -0.150177635366983 1.66563064108617e-08 NA NA NA hsa-miR-195-5p GNAL -1.85907534356434 1.47434041676402e-22 1.33283669629593 1.09261153741281e-06 miRNATAP -0.24531013548398 0.000251456690312491 NA NA NA hsa-miR-195-5p GNB1L -1.85907534356434 1.47434041676402e-22 0.972387895486426 1.58066300637692e-14 mirMAP -0.231461682206991 5.95947549497711e-14 NA NA NA hsa-miR-199a-3p GNG4 -2.3279328685682 1.04468066198593e-17 3.13065787191005 3.93511130749918e-08 mirMAP -0.374794502377641 0.000158579044743277 NA NA NA hsa-miR-195-5p GOLT1B -1.85907534356434 1.47434041676402e-22 0.503253925044857 4.58122371561877e-12 MirTarget -0.102787627970291 7.07551119668321e-09 NA NA NA hsa-miR-199b-5p GPLD1 -0.454049170125872 0.254611775331658 -1.80405318905835 3.64359669483113e-06 miRanda -0.150358394982446 0.00212315612018565 NA NA NA hsa-miR-301a-3p GPR180 0.842910511640361 1.43446467417891e-06 -1.33925503602146 2.10510842041032e-11 mirMAP -0.127803805612102 0.0239077364533458 NA NA NA hsa-miR-199a-5p GPSM2 -1.98848462405923 2.0421622713753e-11 1.45389191030237 4.5650425831655e-20 miRanda -0.161168114134591 6.63848578803597e-10 NA NA NA hsa-miR-301a-3p GRB10 0.842910511640361 1.43446467417891e-06 0.112334132178844 0.195686300080521 MirTarget -0.106462388983824 6.66979693972012e-06 NA NA NA hsa-miR-199a-5p GREB1 -1.98848462405923 2.0421622713753e-11 0.433971867548677 0.16750650822662 miRanda -0.237463988572249 1.89835638331637e-06 NA NA NA hsa-miR-199b-5p GREB1 -0.454049170125872 0.254611775331658 0.433971867548677 0.16750650822662 miRanda -0.250505452537061 5.89828544450652e-11 NA NA NA hsa-let-7c-5p GRPEL2 -1.70744661345097 2.87934212005942e-20 0.65712951992937 1.31065567027786e-19 MirTarget -0.166885706843202 3.33866025922138e-20 NA NA NA hsa-let-7c-5p GSK3A -1.70744661345097 2.87934212005942e-20 0.346560250550711 1.83266290443851e-08 miRNAWalker2_validate -0.101608466684152 2.71277295275603e-11 NA NA NA hsa-miR-199b-5p GSTM2 -0.454049170125872 0.254611775331658 -1.68995962552465 6.56591679423331e-05 miRanda -0.170584903868473 0.00128382979441022 NA NA NA hsa-miR-199a-5p GTF2H2B -1.98848462405923 2.0421622713753e-11 0.24951434585312 0.386030692736906 miRanda -0.104055994333568 0.0239376370176435 NA NA NA hsa-miR-195-5p GTF3C5 -1.85907534356434 1.47434041676402e-22 0.419125796162832 1.00577542504161e-06 MirTarget -0.106807026615213 2.63229173149074e-07 NA NA NA hsa-miR-195-5p H3F3A -1.85907534356434 1.47434041676402e-22 0.588138248662577 4.29295831002756e-09 miRNATAP -0.111261203794379 5.67375734416058e-06 NA NA NA hsa-miR-301a-3p H6PD 0.842910511640361 1.43446467417891e-06 -0.159284401461308 0.269264574065681 mirMAP -0.222121452672345 1.33017663453058e-08 NA NA NA hsa-miR-301a-3p HADHA 0.842910511640361 1.43446467417891e-06 -0.48030417313316 2.15457659669489e-09 MirTarget -0.155086775561914 1.39079232291159e-12 NA NA NA hsa-miR-301a-3p HADHB 0.842910511640361 1.43446467417891e-06 -0.701922184931728 5.12798891512852e-13 MirTarget -0.208403824477803 5.24466633311014e-15 NA NA NA hsa-miR-101-3p HAPLN1 -1.48176407980989 3.98950707385704e-31 1.33038232891219 0.000123661512782167 miRNATAP -0.748884955614574 7.81218074670979e-10 NA NA NA hsa-miR-199a-5p HAPLN1 -1.98848462405923 2.0421622713753e-11 1.33038232891219 0.000123661512782167 MirTarget;miRanda;miRNATAP -0.139769244293178 0.0124305116057871 NA NA NA hsa-miR-195-5p HARS2 -1.85907534356434 1.47434041676402e-22 0.569422522197446 3.41173784588814e-15 MirTarget -0.130244799775317 1.24491627341884e-13 NA NA NA hsa-miR-199a-5p HAUS5 -1.98848462405923 2.0421622713753e-11 1.01933898563413 7.63622455195215e-27 miRanda -0.115935331097192 1.79300764833593e-13 NA NA NA hsa-miR-301a-3p HBP1 0.842910511640361 1.43446467417891e-06 -0.357103377571568 1.81649948774568e-05 MirTarget;miRNATAP -0.169262840679265 4.25710686932563e-14 NA NA NA hsa-miR-301a-3p HCFC2 0.842910511640361 1.43446467417891e-06 -0.267608506836593 0.00645363991292462 MirTarget -0.135707326794452 4.05660994986352e-07 NA NA NA hsa-miR-301a-3p HECA 0.842910511640361 1.43446467417891e-06 -0.704842603143831 7.46272240332447e-12 MirTarget;miRNATAP -0.105625691138722 0.000263546332377661 NA NA NA hsa-miR-301a-3p HECW2 0.842910511640361 1.43446467417891e-06 -0.453603053800375 0.00649211297206005 MirTarget -0.276052046058961 1.04744093474338e-09 NA NA NA hsa-miR-101-3p HEG1 -1.48176407980989 3.98950707385704e-31 0.175697577625922 0.209861547402414 miRNATAP -0.13088929167985 0.00842671138825677 NA NA NA hsa-miR-199a-5p HELLS -1.98848462405923 2.0421622713753e-11 2.62327787224869 1.35869467447747e-28 miRanda -0.209683835276353 1.71950235515908e-07 NA NA NA hsa-miR-301a-3p HERC3 0.842910511640361 1.43446467417891e-06 -1.05715572381348 2.92415816206899e-12 MirTarget -0.328615861880045 2.35151546711696e-15 NA NA NA hsa-miR-199a-5p HHIPL2 -1.98848462405923 2.0421622713753e-11 3.16852872724495 1.73166739412319e-11 miRanda -0.290802399756618 0.000159436570177235 NA NA NA hsa-miR-199b-5p HIBADH -0.454049170125872 0.254611775331658 -0.998115589627497 2.52005924996364e-13 miRanda -0.122214519788381 6.52182317575103e-13 NA NA NA hsa-miR-199a-3p HIC2 -2.3279328685682 1.04468066198593e-17 0.940776893137958 6.46839631810595e-09 miRNATAP -0.10985927757838 9.96318824478023e-05 NA NA NA hsa-miR-107 HIF1A 0.241662461253461 0.0170788899505389 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate;miRTarBase;miRanda -0.436710343430652 2.03313957855482e-10 NA NA NA hsa-miR-17-5p HIF1A 0.698861147045461 2.43854106455398e-05 -0.366176828296648 0.0111002186054683 miRTarBase;MirTarget;TargetScan -0.207486649592262 6.73419034465465e-07 NA NA NA hsa-miR-20a-5p HIF1A 0.854326758727003 5.04256669663285e-07 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate;miRTarBase;MirTarget -0.245558453559623 9.83134714947215e-10 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-33a-5p HIF1A -0.767474460958522 1.09948756118522e-05 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate -0.107227499920455 0.00730487730363833 NA NA NA hsa-miR-616-5p HIF1A 0.150569904638223 0.402836556304524 -0.366176828296648 0.0111002186054683 MirTarget -0.124976106072862 0.00144238259369066 NA NA NA hsa-miR-660-5p HIF1A 0.989755850734071 5.69930767464937e-14 -0.366176828296648 0.0111002186054683 MirTarget -0.249870386379118 1.21860559731773e-06 NA NA NA hsa-miR-93-5p HIF1A 1.39518349670953 2.84167728726712e-25 -0.366176828296648 0.0111002186054683 MirTarget -0.173769064325932 0.000425501783480084 NA NA NA hsa-let-7c-5p HIF1AN -1.70744661345097 2.87934212005942e-20 0.594006229178836 2.59789157148843e-12 MirTarget -0.147609310389359 4.12097290603693e-12 NA NA NA hsa-miR-195-5p HIF1AN -1.85907534356434 1.47434041676402e-22 0.594006229178836 2.59789157148843e-12 MirTarget -0.194514112070235 2.89766526345118e-22 NA NA NA hsa-miR-301a-3p HIPK3 0.842910511640361 1.43446467417891e-06 -1.50429429958896 1.36124385011385e-07 MirTarget -0.252696518763173 0.0015363240256922 NA NA NA hsa-miR-199a-5p HIST1H2BD -1.98848462405923 2.0421622713753e-11 0.0575848369914294 0.768877155051809 miRanda -0.17555353360581 1.24989255818794e-08 NA NA NA hsa-miR-199b-5p HIST1H2BD -0.454049170125872 0.254611775331658 0.0575848369914294 0.768877155051809 miRanda -0.17248840721606 3.1483375775674e-13 NA NA NA hsa-miR-199a-5p HLF -1.98848462405923 2.0421622713753e-11 -1.56359740264692 3.39928227602253e-08 MirTarget;PITA;miRanda;miRNATAP -0.144326368687323 0.00171450202501511 NA NA NA hsa-miR-199b-5p HLF -0.454049170125872 0.254611775331658 -1.56359740264692 3.39928227602253e-08 MirTarget;PITA;miRanda;miRNATAP -0.249776461884032 8.15266324474185e-13 NA NA NA hsa-let-7c-5p HMGA1 -1.70744661345097 2.87934212005942e-20 1.52957485940098 1.79164981120061e-17 MirTarget -0.517651637702838 1.10830470288536e-32 NA NA NA hsa-miR-195-5p HMGA1 -1.85907534356434 1.47434041676402e-22 1.52957485940098 1.79164981120061e-17 miRNATAP -0.423736356735896 9.32597755116828e-23 27175617 Downregulation of miR 195 promotes prostate cancer progression by targeting HMGA1; miR-195 overexpression inhibited cell proliferation cell cycle progression and tumorigenesis via directly targeting HMGA1; Downregulation of HMGA1 expression had an effect similar to miR-195 in the PCa cells; In summary our study suggests that miR-195 functions as a tumor-suppressor gene by downregulating HMGA1 and can be used as a potential target in the treatment of PCa progression;tumorigenesis prostate cancer hsa-let-7c-5p HMGA2 -1.70744661345097 2.87934212005942e-20 1.11519648679255 0.015940340984894 miRNAWalker2_validate;miRTarBase;MirTarget -0.682135030438129 2.57681307834063e-09 NA NA NA hsa-miR-195-5p HMGA2 -1.85907534356434 1.47434041676402e-22 1.11519648679255 0.015940340984894 MirTarget -0.67370658743728 1.13883641249535e-09 NA NA NA hsa-miR-199a-5p HMGCS1 -1.98848462405923 2.0421622713753e-11 0.177750721836838 0.325041585930265 miRanda -0.114429268594284 6.73650649814753e-05 NA NA NA hsa-miR-195-5p HNF1A -1.85907534356434 1.47434041676402e-22 0.217164609385192 0.10308623634593 mirMAP -0.132817793367594 3.54408397691543e-05 NA NA NA hsa-miR-195-5p HNRNPA1 -1.85907534356434 1.47434041676402e-22 0.655818468699744 1.34002254508707e-12 miRNATAP -0.141493039810076 3.76521072119963e-10 NA NA NA hsa-miR-101-3p HNRNPU -1.48176407980989 3.98950707385704e-31 0.372334227200183 2.90242784280694e-12 miRNATAP -0.13718557288576 2.26152090112676e-13 NA NA NA hsa-miR-301a-3p HOMER2 0.842910511640361 1.43446467417891e-06 -1.00582423350523 5.86664467329435e-05 mirMAP -0.513738461691936 2.79704395495073e-14 NA NA NA hsa-miR-199a-5p HOXA13 -1.98848462405923 2.0421622713753e-11 4.75330371864711 5.73667967353751e-22 miRanda -0.26101231560662 0.00169544757436571 NA NA NA hsa-miR-195-5p HOXA3 -1.85907534356434 1.47434041676402e-22 1.48886412457132 4.60517706445809e-06 miRNATAP -0.268613916166981 0.000739937825499676 NA NA NA hsa-miR-195-5p HOXD1 -1.85907534356434 1.47434041676402e-22 2.98402524115611 1.5638033655224e-17 miRNATAP -0.296539436183911 0.000798132582602857 NA NA NA hsa-miR-101-3p HOXD4 -1.48176407980989 3.98950707385704e-31 2.57803490399466 5.69176150346486e-16 miRNATAP -0.556911089427394 1.68720058522792e-06 NA NA NA hsa-miR-199a-5p HRCT1 -1.98848462405923 2.0421622713753e-11 2.16235557863737 3.67324637410944e-12 miRanda -0.377835230433388 2.77459072665555e-14 NA NA NA hsa-miR-199b-5p HRCT1 -0.454049170125872 0.254611775331658 2.16235557863737 3.67324637410944e-12 miRanda -0.2330987719247 2.48183959941453e-09 NA NA NA hsa-miR-101-3p HTRA3 -1.48176407980989 3.98950707385704e-31 0.0343663892215949 0.913601530352526 MirTarget;miRNATAP -0.673445547958666 1.05158345467665e-09 NA NA NA hsa-miR-195-5p HTT -1.85907534356434 1.47434041676402e-22 0.396234962853412 2.19371471763879e-06 MirTarget -0.123289393182998 8.63919617251245e-10 NA NA NA hsa-miR-199a-5p HYAL1 -1.98848462405923 2.0421622713753e-11 -1.0729861072406 5.04666600765142e-09 miRanda -0.107713888879149 0.00030259894893981 NA NA NA hsa-miR-199b-5p HYAL1 -0.454049170125872 0.254611775331658 -1.0729861072406 5.04666600765142e-09 miRanda -0.153730281526674 1.3112162141494e-11 NA NA NA hsa-miR-195-5p IARS -1.85907534356434 1.47434041676402e-22 0.584806432735134 3.98473217675824e-10 MirTarget -0.119630460355977 1.63803293208631e-07 NA NA NA hsa-miR-199b-5p ICK -0.454049170125872 0.254611775331658 0.39119996904083 0.0104331872491703 miRanda -0.132325742514107 9.26136317487352e-13 NA NA NA hsa-miR-301a-3p IDS 0.842910511640361 1.43446467417891e-06 -0.546753809841531 7.44193151771148e-07 mirMAP -0.155676412889912 3.15692125047007e-07 NA NA NA hsa-miR-101-3p IFFO2 -1.48176407980989 3.98950707385704e-31 0.3561399548351 0.00984902835621805 MirTarget -0.279275890178913 7.40107648583549e-09 NA NA NA hsa-let-7c-5p IGDCC3 -1.70744661345097 2.87934212005942e-20 1.93021594033306 4.85774469918296e-06 MirTarget -0.631731378965707 2.0749328122547e-09 NA NA NA hsa-miR-199a-5p IGDCC3 -1.98848462405923 2.0421622713753e-11 1.93021594033306 4.85774469918296e-06 miRNATAP -0.198667415002024 0.00362754801725303 NA NA NA hsa-let-7c-5p IGDCC4 -1.70744661345097 2.87934212005942e-20 1.73062068710294 1.15353341113415e-06 MirTarget -0.669489234913257 2.47646431218122e-14 NA NA NA hsa-miR-103a-2-5p IGF1 1.17085533927423 5.31418969120877e-09 -3.09093589123239 2.87389370715384e-21 mirMAP -0.263504392304743 0.00223342792049484 NA NA NA hsa-miR-15b-3p IGF1 0.238105490431193 0.0997721500357416 -3.09093589123239 2.87389370715384e-21 mirMAP -0.317736514699582 0.00624882495536213 NA NA NA hsa-miR-181a-5p IGF1 0.250113435902954 0.0551933249319293 -3.09093589123239 2.87389370715384e-21 mirMAP -0.504463915639783 8.50109868625984e-05 NA NA NA hsa-miR-181b-5p IGF1 0.488256489401108 0.00105321129419701 -3.09093589123239 2.87389370715384e-21 mirMAP -0.623738116833257 1.69561535563835e-08 NA NA NA hsa-miR-181c-5p IGF1 -0.00639394152050299 0.969127212255928 -3.09093589123239 2.87389370715384e-21 mirMAP -0.239250410659019 0.01885120596434 NA NA NA hsa-miR-19a-3p IGF1 1.01712596153672 2.57753201450625e-07 -3.09093589123239 2.87389370715384e-21 MirTarget -0.400144846493838 1.38857829477185e-06 NA NA NA hsa-miR-19b-3p IGF1 0.601279551368824 0.00016685097085251 -3.09093589123239 2.87389370715384e-21 MirTarget -0.48361890440052 2.97870836726975e-06 NA NA NA hsa-miR-20a-3p IGF1 -0.318177901603857 0.0467885456739855 -3.09093589123239 2.87389370715384e-21 mirMAP -0.361896843485159 0.00054680673837891 NA NA NA hsa-miR-301a-3p IGF1 0.842910511640361 1.43446467417891e-06 -3.09093589123239 2.87389370715384e-21 MirTarget -0.644215183857533 3.25465618219484e-12 NA NA NA hsa-miR-320a IGF1 0.325285936317332 0.0221415065838824 -3.09093589123239 2.87389370715384e-21 miRNATAP -0.253507903136112 0.0320941317708595 NA NA NA hsa-miR-361-5p IGF1 0.233202959858696 0.00961572812255327 -3.09093589123239 2.87389370715384e-21 PITA;mirMAP -0.379123489406991 0.0443597193507629 NA NA NA hsa-miR-362-5p IGF1 0.717921690799312 1.68392734504524e-05 -3.09093589123239 2.87389370715384e-21 mirMAP -0.221743789905403 0.026284257397644 NA NA NA hsa-miR-369-3p IGF1 -0.680843625018478 0.0155063508282041 -3.09093589123239 2.87389370715384e-21 mirMAP -0.150353974270175 0.0114686163117569 NA NA NA hsa-miR-3913-5p IGF1 0.247553671224336 0.062795011081188 -3.09093589123239 2.87389370715384e-21 mirMAP -0.347700367785319 0.00609623314715803 NA NA NA hsa-miR-409-3p IGF1 -0.499649792570937 0.0526751181520117 -3.09093589123239 2.87389370715384e-21 PITA -0.129530044963349 0.0462392123008723 NA NA NA hsa-miR-421 IGF1 0.941856334694081 6.12167297054077e-08 -3.09093589123239 2.87389370715384e-21 PITA -0.472083397878338 5.5786740474017e-07 NA NA NA hsa-miR-454-3p IGF1 0.668749059573955 2.42670710515113e-06 -3.09093589123239 2.87389370715384e-21 MirTarget -0.659716525935208 1.08682616687143e-08 NA NA NA hsa-miR-485-3p IGF1 -0.429504552347863 0.165399880918286 -3.09093589123239 2.87389370715384e-21 mirMAP -0.125118787170308 0.0219899962644741 NA NA NA hsa-miR-940 IGF1 0.453020092551484 0.0177054921651997 -3.09093589123239 2.87389370715384e-21 MirTarget;PITA;miRNATAP -0.258190444399689 0.00419588966919949 NA NA NA hsa-let-7c-5p IGF2BP1 -1.70744661345097 2.87934212005942e-20 4.99826974747196 9.59227871105866e-16 MirTarget -1.64306107284158 3.32791048956517e-27 NA NA NA hsa-miR-195-5p IGF2BP1 -1.85907534356434 1.47434041676402e-22 4.99826974747196 9.59227871105866e-16 mirMAP -1.2866546060087 1.49038171076086e-17 NA NA NA hsa-miR-199a-5p IGF2BP1 -1.98848462405923 2.0421622713753e-11 4.99826974747196 9.59227871105866e-16 miRNATAP -0.227130187678177 0.0281888240439966 NA NA NA hsa-let-7c-5p IGF2BP2 -1.70744661345097 2.87934212005942e-20 1.1359757160287 0.0039471483972338 MirTarget -0.66967665441044 5.02308301505737e-12 NA NA NA hsa-let-7c-5p IGF2BP3 -1.70744661345097 2.87934212005942e-20 2.42884018072337 1.74029814218083e-12 MirTarget -0.792505127678787 9.55879338832913e-21 NA NA NA hsa-miR-199b-5p IGFBP1 -0.454049170125872 0.254611775331658 -2.36697436393479 1.29835005653894e-10 MirTarget;miRanda -0.14785234208335 0.00157773220222413 NA NA NA hsa-miR-101-3p IKZF4 -1.48176407980989 3.98950707385704e-31 0.318939579885376 0.000894578223191946 MirTarget;miRNATAP -0.12888012117442 0.00015128944049216 NA NA NA hsa-miR-301a-3p IL6R 0.842910511640361 1.43446467417891e-06 -0.197357669964791 0.382548993653367 mirMAP -0.270231870208627 1.2309199906437e-05 NA NA NA hsa-miR-301a-3p IL6ST 0.842910511640361 1.43446467417891e-06 -1.91925864959166 1.59476897276323e-08 mirMAP;miRNATAP -0.51713062939287 3.80453654899149e-08 NA NA NA hsa-miR-101-3p INPP5F -1.48176407980989 3.98950707385704e-31 0.439943780947461 4.31972239513017e-05 MirTarget -0.232534937798849 7.18870069614584e-10 NA NA NA hsa-miR-195-5p INPP5J -1.85907534356434 1.47434041676402e-22 1.51506447952545 5.95748863803298e-08 MirTarget;miRNATAP -0.206307146888824 0.00275566965070362 NA NA NA hsa-miR-301a-3p INSIG1 0.842910511640361 1.43446467417891e-06 -0.982451848864065 0.000118571254506076 MirTarget -0.533868927920385 7.82428879164376e-15 NA NA NA hsa-let-7c-5p IP6K1 -1.70744661345097 2.87934212005942e-20 0.889516693961123 4.04556190796781e-31 miRNAWalker2_validate -0.136554103095589 1.44616222053653e-11 NA NA NA hsa-miR-195-5p IP6K1 -1.85907534356434 1.47434041676402e-22 0.889516693961123 4.04556190796781e-31 MirTarget -0.155789243506133 7.80551395684427e-16 NA NA NA hsa-miR-195-5p IPO9 -1.85907534356434 1.47434041676402e-22 0.702597699750934 1.89164484084094e-17 miRNATAP -0.127261232100101 4.72151769900525e-10 NA NA NA hsa-miR-199a-5p IQCH -1.98848462405923 2.0421622713753e-11 0.231269158310297 0.401535839509414 miRanda -0.269837885297262 4.41150719730571e-10 NA NA NA hsa-miR-199b-5p IQCH -0.454049170125872 0.254611775331658 0.231269158310297 0.401535839509414 miRanda -0.220966045807476 4.29980824771233e-11 NA NA NA hsa-miR-101-3p IQGAP3 -1.48176407980989 3.98950707385704e-31 4.31608715455549 7.36930149749722e-54 MirTarget -1.18745954942901 3.56328027355517e-29 NA NA NA hsa-miR-199a-3p IRGQ -2.3279328685682 1.04468066198593e-17 0.902560453855328 7.48220981072122e-23 mirMAP -0.105552975749722 8.62026562734858e-11 NA NA NA hsa-miR-195-5p ITGA2 -1.85907534356434 1.47434041676402e-22 1.53120134028147 5.03620431516659e-09 MirTarget;miRNATAP -0.186383881971086 0.00401127379239066 NA NA NA hsa-miR-199a-3p ITGA6 -2.3279328685682 1.04468066198593e-17 1.33116884445099 5.73067512733422e-21 PITA -0.166829140227348 2.64008048809431e-11 NA NA NA hsa-miR-301a-3p ITPR1 0.842910511640361 1.43446467417891e-06 -0.089448027293932 0.599627751005593 MirTarget;miRNATAP -0.171840493108506 0.00023464350610869 NA NA NA hsa-miR-301a-3p IYD 0.842910511640361 1.43446467417891e-06 -2.66179429977146 1.10383788101266e-13 mirMAP -0.707281421349907 1.1000160591278e-12 NA NA NA hsa-miR-301a-3p JAM2 0.842910511640361 1.43446467417891e-06 -0.411475049759854 0.068165395262772 miRNATAP -0.284729697681092 3.95062193770086e-06 NA NA NA hsa-miR-195-5p JARID2 -1.85907534356434 1.47434041676402e-22 0.389563833569475 2.66930964150282e-05 MirTarget;miRNATAP -0.156351527818008 1.41547841199883e-12 NA NA NA hsa-miR-301a-3p JDP2 0.842910511640361 1.43446467417891e-06 -1.36060874258205 6.48057311731977e-22 mirMAP -0.184603803291406 5.85397732178379e-06 NA NA NA hsa-miR-101-3p JMJD6 -1.48176407980989 3.98950707385704e-31 0.453498144247614 8.63059279440314e-06 mirMAP -0.236705324853721 3.28293346795237e-11 NA NA NA hsa-miR-195-5p JMJD6 -1.85907534356434 1.47434041676402e-22 0.453498144247614 8.63059279440314e-06 mirMAP -0.139130080257761 1.49326465064969e-08 NA NA NA hsa-miR-301a-3p JMY 0.842910511640361 1.43446467417891e-06 -0.0723925290319816 0.482620332419229 MirTarget;miRNATAP -0.106245872676414 0.000164567718839501 NA NA NA hsa-miR-101-3p JPH1 -1.48176407980989 3.98950707385704e-31 0.687134640890904 0.0658260491600653 miRNATAP -0.688994331771796 1.50311394933057e-07 NA NA NA hsa-miR-195-5p KCNJ5 -1.85907534356434 1.47434041676402e-22 1.40144080962597 1.63524689586124e-08 mirMAP -0.221531076223508 0.000289222298763224 NA NA NA hsa-miR-195-5p KCNU1 -1.85907534356434 1.47434041676402e-22 1.87027082992174 0.000475269928317774 MirTarget -0.775397326146817 1.61883544460378e-09 NA NA NA hsa-miR-199a-5p KCNU1 -1.98848462405923 2.0421622713753e-11 1.87027082992174 0.000475269928317774 miRanda -0.450382423348379 1.2192799628933e-07 NA NA NA hsa-miR-199b-5p KCNU1 -0.454049170125872 0.254611775331658 1.87027082992174 0.000475269928317774 miRanda -0.343555510023945 2.08888767813404e-07 NA NA NA hsa-let-7c-5p KCTD17 -1.70744661345097 2.87934212005942e-20 0.903379904615084 0.000443017892119058 MirTarget -0.481480851735286 2.15992968805401e-14 NA NA NA hsa-miR-101-3p KDM3A -1.48176407980989 3.98950707385704e-31 0.260290611309434 0.00489255318634796 miRNATAP -0.118750285639375 0.000284219447895419 NA NA NA hsa-miR-101-3p KDM3B -1.48176407980989 3.98950707385704e-31 0.343619531298047 2.98934052917645e-05 miRNAWalker2_validate;MirTarget -0.13088653008427 7.01760648185319e-06 NA NA NA hsa-miR-301a-3p KDSR 0.842910511640361 1.43446467417891e-06 -0.9262604928472 1.15465124411196e-28 mirMAP -0.140593241909761 6.1266733288476e-09 NA NA NA hsa-miR-199a-3p KIAA0907 -2.3279328685682 1.04468066198593e-17 1.28352453441058 5.50166807221571e-31 MirTarget;PITA -0.116084175951012 9.46262912152067e-09 NA NA NA hsa-miR-301a-3p KIAA1191 0.842910511640361 1.43446467417891e-06 -0.271394863542345 0.00140951611407065 MirTarget -0.164057831775655 6.68404717612165e-13 NA NA NA hsa-let-7c-5p KIAA1429 -1.70744661345097 2.87934212005942e-20 0.529087998279843 4.72515528254996e-10 MirTarget -0.12056072911504 1.72477615472835e-08 NA NA NA hsa-miR-101-3p KIAA1462 -1.48176407980989 3.98950707385704e-31 1.43292602496162 9.79261879524332e-18 miRNAWalker2_validate;MirTarget -0.391588620739128 1.01975678618926e-10 NA NA NA hsa-miR-195-5p KIAA1614 -1.85907534356434 1.47434041676402e-22 1.19012149096204 4.91603849396984e-08 mirMAP -0.158047840295009 0.00330615643009021 NA NA NA hsa-miR-301a-3p KIAA1958 0.842910511640361 1.43446467417891e-06 -0.516263276208278 0.00431830868274674 mirMAP -0.127565583169011 0.010801732036649 NA NA NA hsa-miR-199a-5p KIF11 -1.98848462405923 2.0421622713753e-11 2.12256950255577 1.1749435800197e-28 miRanda -0.180787328921631 2.26413536763616e-08 NA NA NA hsa-miR-301a-3p KIF1B 0.842910511640361 1.43446467417891e-06 -0.0268150253504089 0.784984841184853 mirMAP -0.117866806259294 1.07487973424133e-05 NA NA NA hsa-miR-199a-5p KIF24 -1.98848462405923 2.0421622713753e-11 1.6808929894047 1.02551673781485e-23 miRanda -0.147507529217251 1.40437509462673e-07 NA NA NA hsa-miR-101-3p KIF2A -1.48176407980989 3.98950707385704e-31 0.592913049515548 9.94531203466332e-07 MirTarget -0.289933692186759 9.06437612957447e-12 NA NA NA hsa-miR-101-3p KIF2C -1.48176407980989 3.98950707385704e-31 4.17148645175883 1.99602801148159e-47 miRNAWalker2_validate -1.29669258991646 2.66455298376668e-34 NA NA NA hsa-miR-101-3p KIF5B -1.48176407980989 3.98950707385704e-31 0.188581237036058 0.016945745369247 MirTarget;miRNATAP -0.134024957341069 1.28999451926352e-06 NA NA NA hsa-miR-195-5p KLC2 -1.85907534356434 1.47434041676402e-22 1.16492926016379 3.19134150923749e-23 miRNATAP -0.126940609616693 2.17875257202906e-05 NA NA NA hsa-miR-199b-5p KLF12 -0.454049170125872 0.254611775331658 -0.863221902725629 5.4142350807271e-09 PITA;miRNATAP -0.127159218385683 3.41781268236315e-12 NA NA NA hsa-miR-301a-3p KLF12 0.842910511640361 1.43446467417891e-06 -0.863221902725629 5.4142350807271e-09 mirMAP -0.250542624015469 8.0604667005337e-10 NA NA NA hsa-miR-199b-5p KLF9 -0.454049170125872 0.254611775331658 -1.35905833834713 1.22932810880238e-12 miRanda -0.122031242665316 4.60449551464968e-07 NA NA NA hsa-miR-195-5p KLHDC8B -1.85907534356434 1.47434041676402e-22 0.524333646266656 6.20608833052194e-05 MirTarget -0.144488414066278 5.3293295206379e-06 NA NA NA hsa-miR-301a-3p KLHL15 0.842910511640361 1.43446467417891e-06 -1.43616317329618 4.62856180062188e-29 mirMAP;miRNATAP -0.23594468170927 2.32253827286955e-10 NA NA NA hsa-miR-301a-3p KLHL20 0.842910511640361 1.43446467417891e-06 -0.255034662137329 0.0290056608745733 MirTarget;miRNATAP -0.159770008642012 5.22632202080076e-07 NA NA NA hsa-miR-195-5p KLHL21 -1.85907534356434 1.47434041676402e-22 0.640094972752153 4.1563221568273e-06 mirMAP -0.183143909073861 5.24452474200187e-08 NA NA NA hsa-let-7c-5p KLHL31 -1.70744661345097 2.87934212005942e-20 1.26597140369387 1.58519014245934e-11 MirTarget -0.113451025803371 0.019099409616493 NA NA NA hsa-miR-199b-5p KLHL32 -0.454049170125872 0.254611775331658 -1.04332661505094 1.92394782835792e-05 miRanda -0.142064277272794 2.90437027219688e-06 NA NA NA hsa-miR-199a-5p KLK2 -1.98848462405923 2.0421622713753e-11 0.956832459565319 0.0115033165045538 miRanda -0.234262135885114 0.00010712060777515 NA NA NA hsa-miR-199b-5p KLK2 -0.454049170125872 0.254611775331658 0.956832459565319 0.0115033165045538 miRanda -0.172146367092575 0.000251681450385487 NA NA NA hsa-miR-199a-5p KPNA2 -1.98848462405923 2.0421622713753e-11 1.3966720979923 7.12247839063516e-25 miRanda -0.137651436878523 1.16829688698974e-09 NA NA NA hsa-miR-101-3p KPNB1 -1.48176407980989 3.98950707385704e-31 0.374659403849813 2.0755626878172e-07 MirTarget -0.13975486530773 4.17641544797352e-08 NA NA NA hsa-miR-101-3p KSR2 -1.48176407980989 3.98950707385704e-31 0.506902986173332 0.110760452022147 mirMAP -0.451733791944941 5.77709491523009e-05 NA NA NA hsa-miR-199a-5p LAGE3 -1.98848462405923 2.0421622713753e-11 0.964888860429346 1.5009034148606e-11 miRanda -0.134652372896633 5.36130187182321e-09 NA NA NA hsa-miR-195-5p LAMC1 -1.85907534356434 1.47434041676402e-22 1.18164580989765 3.65525462453826e-17 MirTarget -0.160738646500811 4.77301456025353e-06 NA NA NA hsa-miR-301a-3p LAMC3 0.842910511640361 1.43446467417891e-06 -1.16336935602705 0.000136555756942437 mirMAP -0.224293685945599 0.00812169480621829 NA NA NA hsa-miR-301a-3p LAMP2 0.842910511640361 1.43446467417891e-06 -0.141489314494891 0.203338123114718 mirMAP -0.164101558856888 5.37646897663264e-08 NA NA NA hsa-miR-101-3p LARP1 -1.48176407980989 3.98950707385704e-31 0.631280547716208 2.42762598419254e-16 miRNATAP -0.17320733818157 4.21676427335862e-10 NA NA NA hsa-miR-301a-3p LARP4 0.842910511640361 1.43446467417891e-06 -0.606974985036527 4.17599364737609e-12 MirTarget -0.232907909887844 2.5442584955469e-23 NA NA NA hsa-miR-195-5p LASP1 -1.85907534356434 1.47434041676402e-22 0.523794786889897 6.87898834597451e-10 mirMAP -0.155908690557226 1.766917574524e-14 NA NA NA hsa-let-7c-5p LBR -1.70744661345097 2.87934212005942e-20 0.388685096070557 0.000119421752361692 MirTarget -0.180026392917426 3.89595826197494e-13 NA NA NA hsa-miR-101-3p LBR -1.48176407980989 3.98950707385704e-31 0.388685096070557 0.000119421752361692 miRNAWalker2_validate -0.155873915712138 1.32665994404371e-05 NA NA NA hsa-miR-301a-3p LCOR 0.842910511640361 1.43446467417891e-06 -0.828225234134718 0.000381975258357077 miRNATAP -0.129133540227086 0.0462876488075234 NA NA NA hsa-miR-199b-5p LDHC -0.454049170125872 0.254611775331658 -0.352480592544616 0.425216014227275 miRanda -0.113026052092356 0.0399434890255292 NA NA NA hsa-miR-301a-3p LDLR 0.842910511640361 1.43446467417891e-06 -1.46283255505596 2.87241408741105e-21 miRNATAP -0.257216675235903 5.42969097391737e-09 NA NA NA hsa-miR-195-5p LENG8 -1.85907534356434 1.47434041676402e-22 0.75934588482606 9.40854812638038e-12 mirMAP -0.112522868501371 4.42467835703713e-05 NA NA NA hsa-miR-301a-3p LGSN 0.842910511640361 1.43446467417891e-06 -2.52633123363191 1.49953406371445e-10 mirMAP -0.530130428976051 1.52281696189761e-06 NA NA NA hsa-let-7c-5p LIMD2 -1.70744661345097 2.87934212005942e-20 -0.214037676050721 0.282021903246009 MirTarget -0.218360777157729 1.04445562421957e-05 NA NA NA hsa-let-7c-5p LIMK2 -1.70744661345097 2.87934212005942e-20 0.891712220823075 3.4499668982677e-09 MirTarget -0.236593103071651 4.17089447540952e-10 NA NA NA hsa-let-7c-5p LIN28B -1.70744661345097 2.87934212005942e-20 2.26854994708754 4.69141976850235e-05 MirTarget -0.942677952234562 8.19224435516587e-12 NA NA NA hsa-miR-199a-3p LIN28B -2.3279328685682 1.04468066198593e-17 2.26854994708754 4.69141976850235e-05 MirTarget;PITA;miRNATAP -0.393372531756874 4.26654626214358e-05 NA NA NA hsa-miR-199a-5p LIN7A -1.98848462405923 2.0421622713753e-11 -0.539444523114043 0.000887680837455538 miRanda -0.112674965517093 1.36039209755268e-05 NA NA NA hsa-miR-199b-5p LIN7A -0.454049170125872 0.254611775331658 -0.539444523114043 0.000887680837455538 miRanda -0.108715424444764 5.42744481320334e-08 NA NA NA hsa-miR-199b-5p LIPG -0.454049170125872 0.254611775331658 -1.67366057660381 5.52174082208467e-11 miRanda -0.1042086689786 0.00132121711905622 NA NA NA hsa-miR-301a-3p LMLN 0.842910511640361 1.43446467417891e-06 -0.166069500007594 0.301560342444305 MirTarget;miRNATAP -0.184984402915308 2.59224787848012e-05 NA NA NA hsa-miR-101-3p LMNB1 -1.48176407980989 3.98950707385704e-31 0.979593605630488 1.58971612415829e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.363386426286137 3.63670009776497e-09 NA NA NA hsa-miR-199a-5p LMNB1 -1.98848462405923 2.0421622713753e-11 0.979593605630488 1.58971612415829e-08 miRanda -0.107624820919315 0.000126966407123032 NA NA NA hsa-miR-195-5p LMNB2 -1.85907534356434 1.47434041676402e-22 1.15533579106848 2.8635849155846e-19 mirMAP -0.179824348225847 2.39306441872655e-08 NA NA NA hsa-miR-301a-3p LNPEP 0.842910511640361 1.43446467417891e-06 0.0381901216213942 0.796318936192664 MirTarget;miRNATAP -0.108321555967613 0.00777677839082221 NA NA NA hsa-miR-301a-3p LONRF3 0.842910511640361 1.43446467417891e-06 -0.69388697643543 3.2523505908316e-05 MirTarget -0.202564909664623 1.10686356087797e-05 NA NA NA hsa-miR-301a-3p LPIN1 0.842910511640361 1.43446467417891e-06 -0.135731511477539 0.370548383872963 mirMAP -0.241508963254763 3.97665812671537e-09 NA NA NA hsa-miR-301a-3p LPP 0.842910511640361 1.43446467417891e-06 -0.386324215418135 0.00226265643427216 mirMAP -0.10233320874448 0.00340402033284638 NA NA NA hsa-miR-301a-3p LRIG1 0.842910511640361 1.43446467417891e-06 -0.493686164714059 8.66910284289362e-05 MirTarget -0.157288673628274 5.50629976674073e-06 NA NA NA hsa-miR-101-3p LRP2 -1.48176407980989 3.98950707385704e-31 -1.61490597939815 0.000764566946947575 MirTarget;miRNATAP -0.385350776363838 0.0247617316912192 NA NA NA hsa-miR-301a-3p LRP2BP 0.842910511640361 1.43446467417891e-06 -0.404645143754903 0.00400302962817531 mirMAP -0.105880241417016 0.0064232357812867 NA NA NA hsa-miR-199a-5p LRP4 -1.98848462405923 2.0421622713753e-11 0.524814974673234 0.0714526289696762 miRNATAP -0.114302041065647 0.0142855159419956 NA NA NA hsa-miR-101-3p LRRC14 -1.48176407980989 3.98950707385704e-31 1.36580119828543 4.14163388274102e-35 mirMAP -0.334971095622111 4.74796682483955e-16 NA NA NA hsa-miR-195-5p LRRC14 -1.85907534356434 1.47434041676402e-22 1.36580119828543 4.14163388274102e-35 mirMAP -0.229241173730173 4.43785245567558e-16 NA NA NA hsa-miR-195-5p LRRC20 -1.85907534356434 1.47434041676402e-22 0.592111730852268 3.14506509222137e-05 mirMAP -0.134998177684876 9.7407945201159e-05 NA NA NA hsa-miR-199a-5p LRRC61 -1.98848462405923 2.0421622713753e-11 0.130560593820895 0.327447973107679 miRanda -0.115945998948138 3.31971620618054e-08 NA NA NA hsa-miR-199a-3p LRRC8D -2.3279328685682 1.04468066198593e-17 0.302080319292119 0.000965409775769997 miRNATAP -0.101046546874851 5.69640058771728e-11 NA NA NA hsa-miR-195-5p LSM11 -1.85907534356434 1.47434041676402e-22 0.758646663868328 2.93737544855881e-13 miRNAWalker2_validate;MirTarget -0.168936326594719 2.81361825893652e-11 NA NA NA hsa-miR-301a-3p LTBP4 0.842910511640361 1.43446467417891e-06 -1.48776803748344 1.16033793364097e-10 mirMAP -0.159643936705619 0.0143293565847422 NA NA NA hsa-miR-195-5p LYPLAL1 -1.85907534356434 1.47434041676402e-22 0.334284012812255 0.00426402531538069 MirTarget -0.133895305483156 2.02294637142771e-06 NA NA NA hsa-miR-301a-3p MAF 0.842910511640361 1.43446467417891e-06 -0.855722850331053 1.97147531780957e-13 miRNATAP -0.207955853798463 1.3141252317085e-10 NA NA NA hsa-miR-301a-3p MAFB 0.842910511640361 1.43446467417891e-06 -0.618224180610348 0.000172016470650724 miRNATAP -0.159057228241423 0.00047538962535604 NA NA NA hsa-miR-195-5p MAFG -1.85907534356434 1.47434041676402e-22 1.20304222370093 2.42633916447559e-19 mirMAP -0.252011472043874 2.0751375866285e-14 NA NA NA hsa-miR-301a-3p MAGI2 0.842910511640361 1.43446467417891e-06 -0.990214709412416 4.07215252848078e-08 MirTarget -0.179948301277592 0.000355029906950492 NA NA NA hsa-miR-195-5p MAMSTR -1.85907534356434 1.47434041676402e-22 1.83212439467961 8.29084371980825e-18 MirTarget;miRNATAP -0.354433426576106 1.86522837533853e-11 NA NA NA hsa-miR-101-3p MAP7D1 -1.48176407980989 3.98950707385704e-31 0.448704907787342 1.77667890542935e-06 miRNATAP -0.261776412655167 8.28959641385428e-16 NA NA NA hsa-miR-301a-3p MAPRE3 0.842910511640361 1.43446467417891e-06 -0.343621594450327 0.00477525960848748 MirTarget;miRNATAP -0.188585607312946 1.24462423148694e-08 NA NA NA hsa-miR-301a-3p MARCH2 0.842910511640361 1.43446467417891e-06 0.279772911975377 0.00854034791100721 MirTarget;miRNATAP -0.13936537667587 1.61680647890052e-06 NA NA NA hsa-miR-101-3p MARCKSL1 -1.48176407980989 3.98950707385704e-31 0.308949751259346 0.0647399541617895 miRNATAP -0.561069144936013 2.03128931386394e-23 NA NA NA hsa-miR-301a-3p MAT2B 0.842910511640361 1.43446467417891e-06 -0.273105814463069 0.00263130083756265 MirTarget;miRNATAP -0.18005242160033 1.3947412901744e-13 NA NA NA hsa-miR-199a-5p MAVS -1.98848462405923 2.0421622713753e-11 0.889650514926556 2.47672510928765e-20 mirMAP -0.107023331087106 1.11010750356226e-11 NA NA NA hsa-miR-301a-3p MCC 0.842910511640361 1.43446467417891e-06 -2.36915505634884 5.46995786737825e-22 MirTarget -0.414415709260328 3.75309972523242e-09 NA NA NA hsa-miR-101-3p MCF2L -1.48176407980989 3.98950707385704e-31 0.566616186004937 7.69900993198134e-05 mirMAP;miRNATAP -0.122808277003045 0.0166444089708292 NA NA NA hsa-miR-301a-3p MCFD2 0.842910511640361 1.43446467417891e-06 -0.251093559120312 0.00682863731205307 mirMAP -0.17899979161322 6.65585556279783e-13 NA NA NA hsa-miR-199a-5p MCM10 -1.98848462405923 2.0421622713753e-11 3.44644537200841 1.46743341445993e-36 miRanda -0.26098547695023 3.1433514813163e-08 NA NA NA hsa-let-7c-5p MDFI -1.70744661345097 2.87934212005942e-20 1.613063811487 1.62996375672374e-07 MirTarget -0.449944709746608 5.78696252416618e-09 NA NA NA hsa-miR-301a-3p MDFIC 0.842910511640361 1.43446467417891e-06 -0.770786921792818 0.000159033069942859 MirTarget;miRNATAP -0.12721517403666 0.0249398594170688 NA NA NA hsa-miR-199a-3p MDGA2 -2.3279328685682 1.04468066198593e-17 0.095338851975197 0.824518766363714 MirTarget;miRNATAP -0.159219934803811 0.0313286550086669 NA NA NA hsa-miR-199a-5p MDGA2 -1.98848462405923 2.0421622713753e-11 0.095338851975197 0.824518766363714 miRanda -0.150379519002407 0.0289135249750795 NA NA NA hsa-miR-199b-5p MDGA2 -0.454049170125872 0.254611775331658 0.095338851975197 0.824518766363714 miRanda;miRNATAP -0.136359734213629 0.0106969358097656 NA NA NA hsa-let-7c-5p MDM4 -1.70744661345097 2.87934212005942e-20 0.73357660128009 1.75853291398166e-12 MirTarget -0.16378523997819 4.65469630843185e-10 NA NA NA hsa-miR-195-5p MED22 -1.85907534356434 1.47434041676402e-22 0.901475361439055 2.19971977737607e-20 mirMAP -0.151998744907281 4.00353712006316e-10 NA NA NA hsa-miR-101-3p MEF2D -1.48176407980989 3.98950707385704e-31 0.55349304057489 3.92683185651606e-10 mirMAP;miRNATAP -0.107944424667017 0.000715079042561144 NA NA NA hsa-miR-101-3p MEIS2 -1.48176407980989 3.98950707385704e-31 0.156457406703811 0.32841086989024 miRNATAP -0.258321624619473 4.45672209530812e-06 NA NA NA hsa-miR-301a-3p METTL14 0.842910511640361 1.43446467417891e-06 -0.617533542278558 4.37821797096865e-07 MirTarget -0.210316897251146 3.26627283166198e-10 NA NA NA hsa-miR-101-3p MFSD6 -1.48176407980989 3.98950707385704e-31 0.933089163217582 1.03773441301102e-07 miRNAWalker2_validate -0.577897464012737 7.23455503245124e-22 NA NA NA hsa-let-7c-5p MGAT4A -1.70744661345097 2.87934212005942e-20 0.104155687943847 0.347191347682603 MirTarget -0.139105957783091 3.9224788202799e-07 NA NA NA hsa-miR-101-3p MGAT4A -1.48176407980989 3.98950707385704e-31 0.104155687943847 0.347191347682603 MirTarget -0.20293273499827 1.63236648850463e-07 NA NA NA hsa-miR-301a-3p MGRN1 0.842910511640361 1.43446467417891e-06 -0.276124517149234 0.0013949726932254 mirMAP -0.1056417199744 7.94055861842709e-06 NA NA NA hsa-miR-301a-3p MIER1 0.842910511640361 1.43446467417891e-06 -0.824909145213854 1.42440055744365e-21 MirTarget;miRNATAP -0.144759448059353 4.0457667639105e-09 NA NA NA hsa-miR-195-5p MIER2 -1.85907534356434 1.47434041676402e-22 0.720676275678297 1.33773359074869e-08 mirMAP -0.112830357222442 0.000297993451741304 NA NA NA hsa-miR-101-3p MITF -1.48176407980989 3.98950707385704e-31 -0.406319701896632 0.0146105141167573 miRNATAP -0.15587802043181 0.00845029742537632 23962556 MiR 101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2; We identified microphthalmia-associated transcription factor MITF as a direct target of miR-101; Functional assays showed that miR-101 suppressed invasion and proliferation - an outcome that could be phenocopied by siRNA knockdown of MITF and EZH2 melanoma hsa-miR-199a-5p MKRN3 -1.98848462405923 2.0421622713753e-11 2.45759898527845 1.63558898585444e-09 miRanda -0.345868982717708 1.44296465972233e-07 NA NA NA hsa-miR-199b-5p MKRN3 -0.454049170125872 0.254611775331658 2.45759898527845 1.63558898585444e-09 miRanda -0.171321638493779 0.000899206315745527 NA NA NA hsa-miR-101-3p MLEC -1.48176407980989 3.98950707385704e-31 0.720832989206975 2.19058761047913e-12 MirTarget;miRNATAP -0.198452450692251 7.53439954679852e-08 NA NA NA hsa-miR-195-5p MLLT6 -1.85907534356434 1.47434041676402e-22 0.653121837157595 1.00755151884882e-10 MirTarget -0.120444449948154 1.18426168895607e-06 NA NA NA hsa-miR-199a-3p MMAB -2.3279328685682 1.04468066198593e-17 -0.588907111339767 9.03725382920731e-05 PITA -0.117418021246502 5.44509690046316e-06 NA NA NA hsa-miR-101-3p MNX1 -1.48176407980989 3.98950707385704e-31 1.06785003790784 0.00949441679457583 miRNAWalker2_validate -0.957494452070881 2.46880369890566e-11 NA NA NA hsa-miR-195-5p MOV10 -1.85907534356434 1.47434041676402e-22 0.26470200400998 0.00189960631046037 miRNATAP -0.144870893822571 6.59532667474888e-13 NA NA NA hsa-miR-199a-5p MRAP2 -1.98848462405923 2.0421622713753e-11 2.87660928044156 3.81247995261938e-12 miRanda -0.229362453574796 0.000739153955314117 NA NA NA hsa-miR-101-3p MSH2 -1.48176407980989 3.98950707385704e-31 1.29821037015507 5.01428242220233e-30 miRNAWalker2_validate -0.370327116676286 7.03324820658068e-19 NA NA NA hsa-miR-101-3p MSI1 -1.48176407980989 3.98950707385704e-31 1.99071597222025 2.88067784687686e-05 miRNATAP -1.33773523643684 4.80085705691012e-16 NA NA NA hsa-miR-101-3p MSX1 -1.48176407980989 3.98950707385704e-31 1.64867861143844 2.50604676499963e-18 miRNATAP -0.45990578914333 1.83149066128459e-11 NA NA NA hsa-miR-195-5p MSX1 -1.85907534356434 1.47434041676402e-22 1.64867861143844 2.50604676499963e-18 mirMAP -0.150955236287069 0.00158401840159246 NA NA NA hsa-miR-195-5p MTA3 -1.85907534356434 1.47434041676402e-22 0.780718335428761 2.03728337760139e-17 mirMAP -0.16988275115047 4.41222017069973e-14 NA NA NA hsa-miR-301a-3p MTMR10 0.842910511640361 1.43446467417891e-06 -0.348582480627911 0.000141222859443133 MirTarget -0.195747341181022 1.36837875035684e-15 NA NA NA hsa-miR-195-5p MTMR11 -1.85907534356434 1.47434041676402e-22 1.58660342657416 2.00872981639687e-10 MirTarget -0.17733895815586 0.00418232629395512 NA NA NA hsa-miR-101-3p MTMR2 -1.48176407980989 3.98950707385704e-31 0.400709772822859 0.00100054348711912 MirTarget;miRNATAP -0.395678937140048 9.21787365359144e-22 NA NA NA hsa-miR-195-5p MXD3 -1.85907534356434 1.47434041676402e-22 1.51343901692035 1.01864686099996e-27 miRNATAP -0.26462859614154 3.74186547432617e-14 NA NA NA hsa-miR-101-3p MXRA7 -1.48176407980989 3.98950707385704e-31 0.0792703555372567 0.610154190820347 mirMAP -0.180567565254466 0.00102255139711282 NA NA NA hsa-miR-101-3p MYB -1.48176407980989 3.98950707385704e-31 0.832619773672674 0.00191922988334194 miRNATAP -0.543316757987601 8.23206412612299e-09 NA NA NA hsa-miR-101-3p MYCN -1.48176407980989 3.98950707385704e-31 2.4097398140758 1.13995179469792e-10 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.763111927520903 1.19855922787189e-08 NA NA NA hsa-miR-199b-5p MYO16 -0.454049170125872 0.254611775331658 -1.89247274726404 2.82632602277101e-12 miRanda -0.179481304813791 1.53984197973149e-07 NA NA NA hsa-miR-199a-5p MYO19 -1.98848462405923 2.0421622713753e-11 1.15848516652458 3.55886456804512e-25 MirTarget;miRanda -0.113246128639431 1.24868918415383e-09 NA NA NA hsa-miR-199b-5p MYRIP -0.454049170125872 0.254611775331658 -1.62618818441801 1.98171502701597e-05 miRanda -0.26757392383724 1.37562192001108e-08 NA NA NA hsa-miR-101-3p NACA2 -1.48176407980989 3.98950707385704e-31 0.86377847826631 9.2466018445027e-09 MirTarget -0.20090803058001 0.000205445244545379 NA NA NA hsa-miR-101-3p NACC1 -1.48176407980989 3.98950707385704e-31 0.560076411242838 1.49901024855493e-11 miRNATAP -0.20902793653059 1.03482638172043e-12 NA NA NA hsa-miR-101-3p NAIP -1.48176407980989 3.98950707385704e-31 0.321717102046791 0.104126589295581 MirTarget -0.211286163107867 0.00262059685210964 NA NA NA hsa-miR-101-3p NANOS1 -1.48176407980989 3.98950707385704e-31 0.38458031916332 0.00111708235761936 miRNATAP -0.183113030282493 1.14176778474394e-05 NA NA NA hsa-let-7c-5p NAP1L1 -1.70744661345097 2.87934212005942e-20 0.48873822323481 4.44413744556636e-06 MirTarget -0.248793874030014 2.70783118256391e-22 NA NA NA hsa-miR-195-5p NAT8L -1.85907534356434 1.47434041676402e-22 1.21195978404762 0.000153977148692105 miRNATAP -0.270506991933627 0.000534293958785098 NA NA NA hsa-miR-199a-5p NAT9 -1.98848462405923 2.0421622713753e-11 1.1797127422257 7.98947413582085e-26 miRanda -0.161167844899476 1.41329699481385e-18 NA NA NA hsa-miR-101-3p NAV1 -1.48176407980989 3.98950707385704e-31 0.457357293208876 0.00149629098704196 MirTarget -0.13946460163286 0.00658076581337143 NA NA NA hsa-miR-301a-3p NCKAP5 0.842910511640361 1.43446467417891e-06 -1.99554121140322 2.30439992781689e-15 MirTarget -0.257237363246197 0.000334758524581074 NA NA NA hsa-miR-301a-3p NDEL1 0.842910511640361 1.43446467417891e-06 -0.93256260809174 5.64997674586862e-21 MirTarget;miRNATAP -0.134531730505291 2.23915227144243e-06 NA NA NA hsa-miR-199a-3p NDRG1 -2.3279328685682 1.04468066198593e-17 0.654480193132553 0.000503878236136277 miRNATAP -0.115233736826706 0.000377513795656279 NA NA NA hsa-miR-101-3p NDRG3 -1.48176407980989 3.98950707385704e-31 0.941677746935019 2.65259063843979e-20 miRNATAP -0.415675142260571 2.36092549414471e-32 NA NA NA hsa-miR-101-3p NDRG4 -1.48176407980989 3.98950707385704e-31 -0.54286699943328 0.0347192341596574 miRNATAP -0.276346296623378 0.00247649258813912 NA NA NA hsa-miR-195-5p NDST1 -1.85907534356434 1.47434041676402e-22 0.772480980277764 3.45707692578057e-12 mirMAP -0.125538435512665 4.66796072184641e-06 NA NA NA hsa-miR-301a-3p NDUFA10 0.842910511640361 1.43446467417891e-06 -0.225195500349026 0.00358726261301808 mirMAP -0.102560327370752 1.12906897482005e-06 NA NA NA hsa-miR-199a-3p NEDD4 -2.3279328685682 1.04468066198593e-17 -0.211886112092802 0.209669364741357 MirTarget;PITA;miRNATAP -0.110316228703167 0.00013315318288011 NA NA NA hsa-miR-199a-5p NEDD4L -1.98848462405923 2.0421622713753e-11 0.864887679249782 8.63340597856756e-11 miRanda -0.129105307780598 1.69659492634e-09 NA NA NA hsa-miR-195-5p NF2 -1.85907534356434 1.47434041676402e-22 0.664388802089412 1.31735413428132e-13 MirTarget -0.153750864300167 1.89528376118971e-12 NA NA NA hsa-miR-301a-3p NFIA 0.842910511640361 1.43446467417891e-06 -0.924685216157224 2.60745966247054e-13 miRNATAP -0.312993274216718 7.17366407113242e-20 NA NA NA hsa-miR-301a-3p NFIB 0.842910511640361 1.43446467417891e-06 -0.473125743246742 0.000230272053316789 mirMAP;miRNATAP -0.268196007010132 7.49960913428756e-15 NA NA NA hsa-miR-301a-3p NFIC 0.842910511640361 1.43446467417891e-06 -0.577436174020039 0.00748919731318304 miRNATAP -0.32647980925343 2.91396875081066e-08 NA NA NA hsa-miR-450a-5p NFIX -1.65464197503467 7.32200902934081e-23 -0.0507190853125827 0.707056383209184 mirMAP -0.100759611234918 0.00644407083050987 NA NA NA hsa-miR-195-5p NFRKB -1.85907534356434 1.47434041676402e-22 0.563199098001803 5.81802378481685e-14 MirTarget;miRNATAP -0.125473697362382 6.19146508417778e-12 NA NA NA hsa-miR-195-5p NISCH -1.85907534356434 1.47434041676402e-22 0.507250570071013 8.5871679565154e-14 MirTarget -0.100429571944636 1.53356751151243e-09 NA NA NA hsa-miR-301a-3p NLN 0.842910511640361 1.43446467417891e-06 -0.816592692260158 8.70031751400168e-08 mirMAP -0.260719845850181 4.88235472215832e-10 NA NA NA hsa-let-7c-5p NME6 -1.70744661345097 2.87934212005942e-20 0.606950484577572 4.34851975188018e-13 MirTarget -0.214598920327561 3.81766152781017e-26 NA NA NA hsa-miR-301a-3p NOL4 0.842910511640361 1.43446467417891e-06 -3.34785387311656 6.2589012007234e-19 miRNATAP -0.457395628897155 2.28101441197408e-05 NA NA NA hsa-miR-101-3p NOP2 -1.48176407980989 3.98950707385704e-31 0.549982304060117 5.41528544025205e-09 miRNAWalker2_validate -0.171766975793625 3.23231466635586e-07 NA NA NA hsa-miR-101-3p NOTCH1 -1.48176407980989 3.98950707385704e-31 -0.0333826274090256 0.795560724559869 MirTarget -0.125967613612003 0.00574754801726533 NA NA NA hsa-miR-101-3p NOVA1 -1.48176407980989 3.98950707385704e-31 -0.237953091882935 0.490244872279506 miRNATAP -0.430701367277056 0.000415409531243776 NA NA NA hsa-miR-101-3p NPNT -1.48176407980989 3.98950707385704e-31 0.531754123141975 0.0583025915811082 miRNATAP -0.442928151788507 7.79306969910239e-06 NA NA NA hsa-let-7c-5p NPTX1 -1.70744661345097 2.87934212005942e-20 0.929025880461533 0.00584289763512414 miRNAWalker2_validate -0.349636575478964 3.44078587361936e-05 NA NA NA hsa-miR-101-3p NPTX1 -1.48176407980989 3.98950707385704e-31 0.929025880461533 0.00584289763512414 miRNATAP -0.935344102746145 7.75191716142738e-16 NA NA NA hsa-miR-199a-5p NPY6R -1.98848462405923 2.0421622713753e-11 -0.939363585061003 0.0390000662812723 miRanda -0.150341943169558 0.0396189789864686 NA NA NA hsa-miR-199b-5p NPY6R -0.454049170125872 0.254611775331658 -0.939363585061003 0.0390000662812723 miRanda -0.19725084374103 0.000480350058837327 NA NA NA hsa-miR-199a-5p NR1I3 -1.98848462405923 2.0421622713753e-11 -1.7801397216905 5.5669351448329e-07 miRanda -0.161834621092146 0.00501504941008619 NA NA NA hsa-miR-199b-5p NR1I3 -0.454049170125872 0.254611775331658 -1.7801397216905 5.5669351448329e-07 miRanda -0.312150655245294 8.84648759080335e-13 NA NA NA hsa-let-7c-5p NRARP -1.70744661345097 2.87934212005942e-20 0.806873954048561 5.97890763868229e-07 MirTarget -0.111854005713575 0.00649160992703926 NA NA NA hsa-miR-301a-3p NRBF2 0.842910511640361 1.43446467417891e-06 -1.07496597100173 3.95724974341843e-33 MirTarget;miRNATAP -0.138137695181649 1.7107609388685e-07 NA NA NA hsa-miR-195-5p NRBP1 -1.85907534356434 1.47434041676402e-22 0.26396663832335 0.000177471192913107 MirTarget;miRNATAP -0.141377505219161 7.90725750092731e-18 NA NA NA hsa-miR-199a-3p NRBP2 -2.3279328685682 1.04468066198593e-17 0.559574574924087 0.000815031688707047 MirTarget -0.128591107278892 7.14840449928481e-06 NA NA NA hsa-miR-101-3p NSD1 -1.48176407980989 3.98950707385704e-31 0.62757997714685 2.58183062912293e-14 MirTarget;miRNATAP -0.172300965050972 6.02554419506307e-09 NA NA NA hsa-miR-199a-5p NSDHL -1.98848462405923 2.0421622713753e-11 0.30013694054416 0.0143621665836522 miRanda -0.123188547768154 1.50377075739829e-10 NA NA NA hsa-miR-195-5p NUP210 -1.85907534356434 1.47434041676402e-22 0.782751605380779 4.03899169947893e-10 MirTarget -0.152610267752622 6.62695581456579e-07 NA NA NA hsa-miR-101-3p NUPL2 -1.48176407980989 3.98950707385704e-31 0.574569289088274 9.92116547894647e-18 miRNAWalker2_validate;MirTarget -0.119654755869034 9.32770198574041e-07 NA NA NA hsa-miR-195-5p NUTF2 -1.85907534356434 1.47434041676402e-22 0.423273750605189 1.29748402471219e-05 mirMAP -0.124996487551895 9.54748106498524e-08 NA NA NA hsa-miR-199a-5p OAZ3 -1.98848462405923 2.0421622713753e-11 1.11573388741878 2.8108480685416e-10 miRanda -0.100771109684826 0.000473728156360302 NA NA NA hsa-miR-195-5p OCRL -1.85907534356434 1.47434041676402e-22 0.818629455066819 1.52199258091119e-16 miRNATAP -0.109104506651881 1.06685641897057e-05 NA NA NA hsa-miR-101-3p OGT -1.48176407980989 3.98950707385704e-31 0.641051374032147 6.95763329953705e-13 miRNATAP -0.148363222875773 4.2128165245105e-06 NA NA NA hsa-miR-195-5p OGT -1.85907534356434 1.47434041676402e-22 0.641051374032147 6.95763329953705e-13 miRNATAP -0.112691030950714 2.95242967912385e-07 NA NA NA hsa-miR-195-5p ONECUT2 -1.85907534356434 1.47434041676402e-22 0.120890541524141 0.551384233388767 miRNATAP -0.192022945951844 8.80151774710757e-05 NA NA NA hsa-miR-199a-5p ONECUT2 -1.98848462405923 2.0421622713753e-11 0.120890541524141 0.551384233388767 PITA;miRNATAP -0.190508212101219 2.28953600091233e-09 NA NA NA hsa-miR-199b-5p ONECUT2 -0.454049170125872 0.254611775331658 0.120890541524141 0.551384233388767 PITA;miRNATAP -0.134813935678439 5.8700811696266e-08 NA NA NA hsa-miR-301a-3p ONECUT2 0.842910511640361 1.43446467417891e-06 0.120890541524141 0.551384233388767 mirMAP -0.116111827386776 0.0380280910866663 NA NA NA hsa-miR-101-3p ORAI2 -1.48176407980989 3.98950707385704e-31 0.147939436354318 0.336648923993268 mirMAP -0.426842224291779 5.76407724472312e-16 NA NA NA hsa-miR-195-5p OTUB1 -1.85907534356434 1.47434041676402e-22 0.25138819190632 0.000439411668726384 miRNATAP -0.10051598464306 3.91602288577731e-09 NA NA NA hsa-miR-199a-5p OTUB2 -1.98848462405923 2.0421622713753e-11 1.59577360116419 6.69566513486211e-29 miRanda -0.145485117315329 1.64376890552895e-09 NA NA NA hsa-miR-101-3p OTUD3 -1.48176407980989 3.98950707385704e-31 0.701071239885856 4.04593404284281e-08 miRNATAP -0.202188135243187 9.69424352236e-06 NA NA NA hsa-miR-301a-3p OTUD4 0.842910511640361 1.43446467417891e-06 -0.781147538845887 2.89406618341624e-12 mirMAP;miRNATAP -0.137680560346085 1.16546150135434e-05 NA NA NA hsa-miR-195-5p OTX1 -1.85907534356434 1.47434041676402e-22 3.02229789234294 1.88083127727288e-19 miRNATAP -0.339149835138165 6.35897383404346e-05 NA NA NA hsa-miR-199a-5p OTX1 -1.98848462405923 2.0421622713753e-11 3.02229789234294 1.88083127727288e-19 PITA;miRanda;miRNATAP -0.206746205522734 0.000220438062459226 NA NA NA hsa-miR-301a-3p PAFAH1B2 0.842910511640361 1.43446467417891e-06 -0.49682050496285 0.00261299670984924 MirTarget -0.138665549310868 0.00236010151524665 NA NA NA hsa-miR-301a-3p PAFAH2 0.842910511640361 1.43446467417891e-06 -0.96194020986197 7.2261532055047e-20 mirMAP -0.300670434079624 8.24802610988781e-26 NA NA NA hsa-let-7c-5p PAG1 -1.70744661345097 2.87934212005942e-20 -0.0641776217701535 0.737132600565642 MirTarget -0.11049170694399 0.0212818061791696 NA NA NA hsa-miR-199b-5p PAGE4 -0.454049170125872 0.254611775331658 2.65912018752695 9.14004796834807e-05 miRanda -0.597773457050658 5.80024966341826e-13 NA NA NA hsa-let-7c-5p PAK4 -1.70744661345097 2.87934212005942e-20 0.332066945941027 0.000554855795687645 miRNAWalker2_validate -0.146202847790971 7.66415471826461e-10 NA NA NA hsa-miR-301a-3p PALM2 0.842910511640361 1.43446467417891e-06 -2.07895743328401 4.60304002325711e-20 mirMAP -0.484533436882648 2.6025568457244e-14 NA NA NA hsa-miR-199a-5p PAQR9 -1.98848462405923 2.0421622713753e-11 0.136400501110993 0.5121608638586 miRanda -0.12763956832164 0.000115134999252432 NA NA NA hsa-let-7c-5p PARD6B -1.70744661345097 2.87934212005942e-20 -0.0933903062942685 0.430333811242109 MirTarget -0.142218447562304 1.26822558335396e-06 NA NA NA hsa-miR-301a-3p PBX1 0.842910511640361 1.43446467417891e-06 -1.3362034667203 5.80856733969378e-07 mirMAP -0.157829558863716 0.0349772088506917 NA NA NA hsa-miR-301a-3p PCBD2 0.842910511640361 1.43446467417891e-06 -0.166255826334794 0.0587007532530656 mirMAP -0.138509219249452 5.74532232066395e-09 NA NA NA hsa-miR-195-5p PCBP4 -1.85907534356434 1.47434041676402e-22 1.08551361354041 1.48859990502195e-18 MirTarget -0.247149748082778 2.73789082130158e-16 NA NA NA hsa-miR-301a-3p PCCB 0.842910511640361 1.43446467417891e-06 -0.680050604129235 3.63211805735208e-09 mirMAP -0.295241796442176 7.94911337696221e-22 NA NA NA hsa-miR-199b-5p PCDH20 -0.454049170125872 0.254611775331658 -1.79960788102185 0.000408842556542699 miRanda -0.215346468480313 0.000702656310792517 NA NA NA hsa-miR-195-5p PCDHA1 -1.85907534356434 1.47434041676402e-22 2.03421582854944 8.2069018136988e-06 MirTarget -0.418191389650002 0.000176728967688825 NA NA NA hsa-let-7c-5p PCGF3 -1.70744661345097 2.87934212005942e-20 0.167536921370584 0.0398744101142924 miRNAWalker2_validate;MirTarget -0.113853768613945 1.4497220623856e-08 NA NA NA hsa-miR-199b-5p PCK1 -0.454049170125872 0.254611775331658 -3.84263732288163 1.8708607706947e-16 miRanda -0.159983199334472 0.00803410864574819 NA NA NA hsa-miR-195-5p PCYT2 -1.85907534356434 1.47434041676402e-22 0.00446147360920346 0.974419085805155 mirMAP -0.107135741037685 0.0014458148350505 NA NA NA hsa-miR-199a-5p PCYT2 -1.98848462405923 2.0421622713753e-11 0.00446147360920346 0.974419085805155 mirMAP -0.146264269177867 1.59489476941477e-11 NA NA NA hsa-miR-199b-5p PCYT2 -0.454049170125872 0.254611775331658 0.00446147360920346 0.974419085805155 mirMAP -0.151407578895794 4.08108890631449e-20 NA NA NA hsa-miR-301a-3p PCYT2 0.842910511640361 1.43446467417891e-06 0.00446147360920346 0.974419085805155 mirMAP -0.107561696761009 0.00491222958004213 NA NA NA hsa-miR-301a-3p PDCD1LG2 0.842910511640361 1.43446467417891e-06 -1.71871038152299 5.07295006749358e-14 MirTarget -0.185801051163659 0.00422250761123041 NA NA NA hsa-miR-195-5p PDDC1 -1.85907534356434 1.47434041676402e-22 0.533443153710714 1.8670143731137e-08 mirMAP -0.157063346593752 5.69186964879833e-12 NA NA NA hsa-miR-301a-3p PDE3B 0.842910511640361 1.43446467417891e-06 -0.985225314310314 3.21148892630576e-08 MirTarget -0.213075122337227 1.73715053871704e-05 NA NA NA hsa-miR-101-3p PDE4A -1.48176407980989 3.98950707385704e-31 -0.161954171824426 0.42151694325105 miRNATAP -0.325786300375901 4.29091830073092e-06 NA NA NA hsa-miR-101-3p PDE4D -1.48176407980989 3.98950707385704e-31 -0.666934323578114 0.000685777052439917 miRNATAP -0.146094807452614 0.0375415130591126 NA NA NA hsa-miR-195-5p PDIA6 -1.85907534356434 1.47434041676402e-22 0.350118085158078 2.30888982321685e-05 MirTarget -0.109126728062614 4.18566337380474e-08 NA NA NA hsa-miR-301a-3p PDIK1L 0.842910511640361 1.43446467417891e-06 -0.0468630905538001 0.608073460423057 MirTarget -0.119553004216293 1.47153724881342e-06 NA NA NA hsa-miR-101-3p PDP1 -1.48176407980989 3.98950707385704e-31 -0.55248328428444 0.00829430941999616 MirTarget -0.263704849122117 0.000384744844373528 NA NA NA hsa-miR-106a-5p PDPK1 -0.464229535269236 0.009724944358047 0.309856812256619 0.0145897035970451 mirMAP -0.106603481622112 0.00191993221102484 NA NA NA hsa-miR-128-3p PDPK1 0.289735108018712 0.0114419474207889 0.309856812256619 0.0145897035970451 miRNAWalker2_validate -0.106949401229151 0.0492467114400439 NA NA NA hsa-miR-148b-5p PDPK1 0.295777213389605 0.0255749859535438 0.309856812256619 0.0145897035970451 mirMAP -0.104191728947125 0.0265785096620784 NA NA NA hsa-miR-22-5p PDPK1 -0.630365901263172 3.32415348030414e-05 0.309856812256619 0.0145897035970451 miRNATAP -0.114858817985206 0.004539264565349 NA NA NA hsa-miR-24-3p PDPK1 -0.257825594021966 0.00689742600215061 0.309856812256619 0.0145897035970451 miRNAWalker2_validate -0.189377775001018 0.00377818335280003 NA NA NA hsa-miR-27a-3p PDPK1 -0.370807380415112 0.00875721956202713 0.309856812256619 0.0145897035970451 miRNATAP -0.12746674939881 0.00357863446842311 NA NA NA hsa-miR-324-3p PDPK1 0.260348469146494 0.0506141704203545 0.309856812256619 0.0145897035970451 mirMAP -0.133875113382166 0.00407187982303137 NA NA NA hsa-miR-326 PDPK1 -1.881935132554 1.68087316863775e-21 0.309856812256619 0.0145897035970451 mirMAP -0.115285864383535 0.000115621382458437 NA NA NA hsa-miR-330-3p PDPK1 -0.332364259424489 0.0316051913061459 0.309856812256619 0.0145897035970451 mirMAP -0.199719327448706 8.51522334736582e-07 NA NA NA hsa-miR-330-5p PDPK1 0.442231058604099 0.0053308560843808 0.309856812256619 0.0145897035970451 mirMAP -0.174352569124449 6.44046033884862e-06 NA NA NA hsa-miR-331-3p PDPK1 -0.283974346994635 0.0373785411053202 0.309856812256619 0.0145897035970451 miRNAWalker2_validate -0.14393772894958 0.0015300062995931 NA NA NA hsa-miR-342-3p PDPK1 -0.319677314984262 0.0449813878317147 0.309856812256619 0.0145897035970451 mirMAP -0.202682473172801 1.2852571763811e-07 NA NA NA hsa-miR-424-5p PDPK1 -2.62653257498508 2.38997974737991e-50 0.309856812256619 0.0145897035970451 mirMAP -0.106052465451978 0.000611771334502943 NA NA NA hsa-miR-542-3p PDPK1 -1.31351015149842 3.64642423288576e-22 0.309856812256619 0.0145897035970451 mirMAP -0.149412531526728 0.000555422280439471 NA NA NA hsa-miR-590-5p PDPK1 -0.103355559980404 0.310027295317092 0.309856812256619 0.0145897035970451 miRanda -0.154730721244174 0.0118516546451218 NA NA NA hsa-miR-744-5p PDPK1 -0.378868377317939 0.00125071229180016 0.309856812256619 0.0145897035970451 miRNAWalker2_validate -0.143178711893691 0.0067023429085085 NA NA NA hsa-miR-766-3p PDPK1 0.199979324759329 0.257230732626744 0.309856812256619 0.0145897035970451 mirMAP -0.152946333354899 1.15508230226764e-05 NA NA NA hsa-miR-195-5p PDXK -1.85907534356434 1.47434041676402e-22 0.60795962520192 3.81588352286127e-09 MirTarget -0.178753460323381 5.7290806300676e-13 NA NA NA hsa-miR-199a-5p PDZK1 -1.98848462405923 2.0421622713753e-11 0.409254082629943 0.0413109586291865 miRanda -0.175166811664139 3.20082574917879e-08 NA NA NA hsa-miR-199b-5p PDZK1 -0.454049170125872 0.254611775331658 0.409254082629943 0.0413109586291865 miRanda -0.116313029715528 2.56771619058222e-06 NA NA NA hsa-miR-101-3p PEA15 -1.48176407980989 3.98950707385704e-31 1.12311402840601 1.26777023794476e-31 mirMAP -0.372000492762324 3.86889826021288e-27 NA NA NA hsa-miR-199b-5p PFDN6 -0.454049170125872 0.254611775331658 0.844362110855891 3.77599962635258e-12 miRanda -0.110072544400018 2.93583016418131e-13 NA NA NA hsa-miR-195-5p PFKFB4 -1.85907534356434 1.47434041676402e-22 1.25161751152843 3.78691544751763e-10 MirTarget -0.35745885858008 1.20968477268083e-13 NA NA NA hsa-miR-199a-5p PFKFB4 -1.98848462405923 2.0421622713753e-11 1.25161751152843 3.78691544751763e-10 miRanda -0.175050548315091 5.67895898919854e-08 NA NA NA hsa-miR-195-5p PGPEP1 -1.85907534356434 1.47434041676402e-22 0.167322965185669 0.143077647806586 mirMAP -0.133576458454555 1.09492378415347e-06 NA NA NA hsa-miR-199a-3p PGPEP1 -2.3279328685682 1.04468066198593e-17 0.167322965185669 0.143077647806586 mirMAP -0.117208622178761 1.13807850501199e-09 NA NA NA hsa-miR-199a-5p PGPEP1 -1.98848462405923 2.0421622713753e-11 0.167322965185669 0.143077647806586 miRanda -0.100847145546452 2.02846524187353e-08 NA NA NA hsa-miR-195-5p PHF19 -1.85907534356434 1.47434041676402e-22 1.31515412555065 1.20077313718174e-18 miRNATAP -0.137522966731781 0.000264227674916456 25955388 MicroRNA 195 5p acts as an anti oncogene by targeting PHF19 in hepatocellular carcinoma; In addition it has been shown that miR-195 plays an important role in the molecular etiology of HCC; however the effect and possible mechanism of PHF19 on HCC is unclear and the association between PHF19 and miR-195 has seldom been addressed; Our results showed that PHF19 is a potential target of hsa-miR-195-5p based on a bioinformatic analysis and results of a luciferase reporter assay; PHF19 was downregulated after transfection with hsa-miR-195-5p mimics; In contrast overexpression of hsa-miR-195-5p in hepatoma cells reduced PHF19 expression leading to suppression of hepatoma cell invasion migration and proliferation in vitro; In addition PHF19 markedly promoted the growth of xenograft tumors while hsa-miR-195-5p markedly suppressed the growth of xenograft tumors in nude mice; These results provide evidence that PHF19 promotes HCC and is regulated by the tumor-suppressor miR-195-5p liver cancer hsa-miR-195-5p PHF21A -1.85907534356434 1.47434041676402e-22 0.536739369729245 3.79383887055722e-09 MirTarget -0.115821393179887 1.80518924760974e-07 NA NA NA hsa-miR-301a-3p PHF8 0.842910511640361 1.43446467417891e-06 -0.31261098131684 0.0111347795985364 mirMAP -0.189904606662203 1.40114305110439e-08 NA NA NA hsa-miR-101-3p PHTF2 -1.48176407980989 3.98950707385704e-31 0.479833616664147 1.04897601040811e-06 miRNATAP -0.24493575875429 9.84801486204131e-13 NA NA NA hsa-miR-199a-3p PHYHIPL -2.3279328685682 1.04468066198593e-17 0.875425421453594 0.00299276786748856 PITA -0.327282837795302 5.08319660780765e-11 NA NA NA hsa-miR-195-5p PI4KB -1.85907534356434 1.47434041676402e-22 0.751391909069037 1.32868417915592e-20 miRNATAP -0.106350176976151 1.5229644901896e-07 NA NA NA hsa-miR-301a-3p PIGK 0.842910511640361 1.43446467417891e-06 -0.291923881998766 0.00135698257670697 MirTarget -0.11711560986177 2.61411402817645e-06 NA NA NA hsa-miR-199b-5p PIGV -0.454049170125872 0.254611775331658 -1.06694022361393 1.36487137295822e-19 miRanda -0.114137524724886 1.56813892835567e-14 NA NA NA hsa-miR-195-5p PIGZ -1.85907534356434 1.47434041676402e-22 0.879865611720272 3.11062927491165e-07 mirMAP -0.166344278607577 7.8208661730416e-05 NA NA NA hsa-miR-101-3p PIK3C2B -1.48176407980989 3.98950707385704e-31 0.902726755526454 2.91031962163582e-12 MirTarget;miRNATAP -0.27573967035318 2.67658986785092e-09 NA NA NA hsa-miR-17-5p PIK3CA 0.698861147045461 2.43854106455398e-05 -0.417502897789422 0.000144089141837096 miRNAWalker2_validate -0.140034439363479 1.22830047865626e-05 NA NA NA hsa-miR-339-5p PIK3CA 0.280589919878422 0.0355660282647215 -0.417502897789422 0.000144089141837096 miRanda -0.161250958910826 6.10867364493006e-05 NA NA NA hsa-miR-501-5p PIK3CA 1.15231083477882 2.98906150004088e-10 -0.417502897789422 0.000144089141837096 mirMAP -0.110297544989421 0.000121810192831398 NA NA NA hsa-miR-126-5p PIK3CB -0.428561469405594 6.6035585844222e-05 0.100967159570933 0.165951003911767 mirMAP -0.182730257201379 1.71015167377407e-08 NA NA NA hsa-miR-204-5p PIK3CB -0.537962150012103 0.0330895493358849 0.100967159570933 0.165951003911767 miRNATAP -0.108408817404481 9.83805003133513e-16 NA NA NA hsa-miR-32-5p PIK3CB 0.0806126674664016 0.548984992497432 0.100967159570933 0.165951003911767 miRNATAP -0.140663620385439 6.63155819716864e-08 NA NA NA hsa-miR-1468-5p PIK3CD -1.21475558175193 2.52286949987832e-09 -0.877858532886072 2.39332269929579e-06 MirTarget -0.114605918546385 0.00956114952826845 NA NA NA hsa-miR-30b-3p PIK3CD -0.439724365151373 0.000947180503583586 -0.877858532886072 2.39332269929579e-06 MirTarget -0.241027174305288 0.000454965508091255 NA NA NA hsa-miR-30d-5p PIK3CD 0.718283816348023 2.47422074061352e-08 -0.877858532886072 2.39332269929579e-06 MirTarget;miRNATAP -0.313277633599958 7.26196135533465e-06 NA NA NA hsa-miR-30e-5p PIK3CD -0.627815042856657 3.02205690184908e-10 -0.877858532886072 2.39332269929579e-06 MirTarget -0.253648851782905 0.00528999528593308 NA NA NA hsa-miR-616-5p PIK3CD 0.150569904638223 0.402836556304524 -0.877858532886072 2.39332269929579e-06 MirTarget -0.206581353665342 5.02538338243613e-05 NA NA NA hsa-miR-103a-3p PIK3R1 0.765568928457606 3.05497476509383e-12 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.187692597616198 0.00702590214654354 NA NA NA hsa-miR-106b-5p PIK3R1 0.648901865047099 8.24870862047885e-09 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.369244291882445 4.59379549667075e-08 NA NA NA hsa-miR-1301-3p PIK3R1 1.12156714169769 4.22404125385203e-10 -0.891953424131491 1.38465728969785e-08 MirTarget -0.26088137729301 3.97606431390706e-10 NA NA NA hsa-miR-132-3p PIK3R1 0.323796239695997 0.00272093067935091 -0.891953424131491 1.38465728969785e-08 MirTarget -0.517351445825174 2.17222827385203e-13 NA NA NA hsa-miR-15b-5p PIK3R1 0.230566941413564 0.0824765001857479 -0.891953424131491 1.38465728969785e-08 MirTarget -0.132325827339178 0.0249531550846148 NA NA NA hsa-miR-17-5p PIK3R1 0.698861147045461 2.43854106455398e-05 -0.891953424131491 1.38465728969785e-08 MirTarget;TargetScan;miRNATAP -0.213954808771155 3.8587060059728e-06 NA NA NA hsa-miR-185-5p PIK3R1 0.480006257154717 6.35758891340152e-07 -0.891953424131491 1.38465728969785e-08 miRNATAP -0.255181123475439 0.00153792085091181 NA NA NA hsa-miR-188-5p PIK3R1 1.11646899351496 9.56686958408598e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.178093775716465 5.33015486626271e-05 NA NA NA hsa-miR-200c-3p PIK3R1 -0.104675615392797 0.716957669484981 -0.891953424131491 1.38465728969785e-08 mirMAP -0.105107802462856 9.06963579759966e-05 NA NA NA hsa-miR-20a-5p PIK3R1 0.854326758727003 5.04256669663285e-07 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.137431012149634 0.00237710222818209 NA NA NA hsa-miR-21-5p PIK3R1 1.51084295924322 1.54551622173259e-34 -0.891953424131491 1.38465728969785e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.626634426633867 6.01244523464713e-31 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 -0.288359631986802 0.100392159518997 -0.891953424131491 1.38465728969785e-08 MirTarget -0.258090192317157 3.95293509038579e-09 NA NA NA hsa-miR-221-3p PIK3R1 1.12244756358612 3.48370308238012e-13 -0.891953424131491 1.38465728969785e-08 MirTarget -0.217914846238424 7.87055620620445e-06 NA NA NA hsa-miR-222-3p PIK3R1 1.08574156066353 1.76407192348131e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.256619417997498 3.41697791848384e-08 NA NA NA hsa-miR-324-3p PIK3R1 0.260348469146494 0.0506141704203545 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.281792149179102 1.26555231509763e-06 NA NA NA hsa-miR-330-3p PIK3R1 -0.332364259424489 0.0316051913061459 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.212492102885122 3.44445995574159e-05 NA NA NA hsa-miR-338-5p PIK3R1 -0.221898432884726 0.252390988727086 -0.891953424131491 1.38465728969785e-08 PITA -0.143685656767977 0.000366657184559181 NA NA NA hsa-miR-409-3p PIK3R1 -0.499649792570937 0.0526751181520117 -0.891953424131491 1.38465728969785e-08 mirMAP -0.110448878014769 0.000237041711390918 NA NA NA hsa-miR-493-5p PIK3R1 -0.198321662045422 0.502870277689198 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.103739426368655 7.76271840065789e-05 NA NA NA hsa-miR-582-5p PIK3R1 -0.680189083316822 0.00103755166534107 -0.891953424131491 1.38465728969785e-08 mirMAP -0.138461163257927 0.00021364752999012 NA NA NA hsa-miR-589-3p PIK3R1 1.16846704028095 5.88525574424201e-11 -0.891953424131491 1.38465728969785e-08 mirMAP -0.21021578613876 1.13421126603334e-06 NA NA NA hsa-miR-590-5p PIK3R1 -0.103355559980404 0.310027295317092 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRanda;miRNATAP -0.299776876388425 9.9413226282672e-05 NA NA NA hsa-miR-629-3p PIK3R1 -0.315338123880353 0.119091248294946 -0.891953424131491 1.38465728969785e-08 MirTarget -0.182940394280375 3.19896248240917e-06 NA NA NA hsa-miR-93-5p PIK3R1 1.39518349670953 2.84167728726712e-25 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.319783065556515 2.89613370212511e-09 NA NA NA hsa-miR-126-3p PIK3R2 -0.652349350198172 9.37876280344772e-09 0.902461657566753 1.95242785807378e-14 miRNAWalker2_validate;miRTarBase -0.307009584408785 1.4469316595199e-09 25240815;26384552;27578985;21249429;26191164 MiR 126 3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2; LRP6 and PIK3R2 were identified as targets of miR-126-3p; Silencing LRP6 and PIK3R2 had similar effects of miR-126-3p restoration on metastasis and angiogenesis individually in HCC cells; Furthermore the miR-126-3p level was inversely correlated with LRP6 and PIK3R2 in HCC tissues; In addition the rescue experiments indicated that the metastasis and angiogenesis functions of miR-126-3p were mediated by LRP6 and PIK3R2;MicroRNA 126 suppresses proliferation of undifferentiated BRAFV600E and BRAFWT thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K AKT proliferation survival signalling pathway; In addition miR-126 was found to act as proliferation suppressor targeting PIK3R2 gene and reducing p85β a regulatory subunit of PI3K kinase protein translation and lower AKT kinase activity;MiR 126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2 mediated PI3K/Akt signaling pathway; A direct regulatory relationship between miR-126 and the PIK3R2 gene was demonstrated by luciferase reporter assays; Quantitative real-time polymerase chain reaction was used to measure miR-126 and PIK3R2 expressions; Luciferase assays showed that miR-126 significantly inhibited the PIK3R2 3' untranslated region 3'UTR luciferase reporter activity P<0.05; Overexpression of miR-126 negatively regulated the target gene PIK3R2 and further inhibited the PI3K/Akt signaling pathway thereby inhibiting proliferation migration and invasion and promoting apoptosis in BLS cells;Endothelial specific intron derived miR 126 is down regulated in human breast cancer and targets both VEGFA and PIK3R2; VEGFA and PIK3R2 were confirmed as the targets of miR-126 by luciferase reporter assay and Western blot;Restoration of miR-126 in EC109 cells induced a reduction in PIK3R2 protein levels accompanied with a substantial reduction in phosphorylated AKT levels in EC109 cells suggesting impairment in PI3K/AKT signaling pathway; The luciferase reporter assay confirmed that PIK3R2 was a direct target of miR-126; Taken together our study suggests that miR-126 functions as a potential tumor suppressor in ESCC progression via regulating PI3K/AKT signaling pathway partly by targeting PIK3R2 and targeting of miR-126 may provide a novel strategy for the diagnosis and treatment of ESCC metastasis;poor survival;;;progression liver cancer;thyroid cancer;bladder cancer;breast cancer;esophageal cancer hsa-miR-28-5p PIK3R2 -0.430964830599964 2.67367257252925e-06 0.902461657566753 1.95242785807378e-14 miRanda -0.216513318430191 0.000794318920407844 NA NA NA hsa-miR-30a-5p PIK3R2 -0.626257932887855 0.000108198196973765 0.902461657566753 1.95242785807378e-14 miRNATAP -0.144672134574065 6.66511974688791e-05 NA NA NA hsa-miR-30e-5p PIK3R2 -0.627815042856657 3.02205690184908e-10 0.902461657566753 1.95242785807378e-14 miRNATAP -0.27051427660089 3.48529317139267e-06 NA NA NA hsa-miR-3607-3p PIK3R2 -2.15518588554493 1.03390728226728e-23 0.902461657566753 1.95242785807378e-14 mirMAP;miRNATAP -0.192639313478842 2.68262287342929e-14 NA NA NA hsa-miR-19a-3p PIK3R3 1.01712596153672 2.57753201450625e-07 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.104972668125809 0.000194207587349022 NA NA NA hsa-miR-19b-3p PIK3R3 0.601279551368824 0.00016685097085251 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.156884173334155 7.42851910353984e-06 NA NA NA hsa-miR-222-5p PIK3R3 0.125716360553359 0.487423909991138 0.635454203069077 2.81455381573105e-08 mirMAP -0.124074211713995 7.25281139850942e-05 NA NA NA hsa-miR-26b-5p PIK3R3 -1.10804856399744 4.14176110314282e-22 0.635454203069077 2.81455381573105e-08 miRNATAP -0.11879971388214 0.0117895234047857 NA NA NA hsa-miR-32-5p PIK3R3 0.0806126674664016 0.548984992497432 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.115094122727672 0.00654760226880116 NA NA NA hsa-miR-331-3p PIK3R3 -0.283974346994635 0.0373785411053202 0.635454203069077 2.81455381573105e-08 miRNAWalker2_validate;PITA -0.141431444954819 0.000659359723681179 NA NA NA hsa-miR-335-3p PIK3R3 -0.275199247483111 0.106629165248783 0.635454203069077 2.81455381573105e-08 mirMAP -0.159933987443154 1.18680673169693e-06 NA NA NA hsa-miR-454-3p PIK3R3 0.668749059573955 2.42670710515113e-06 0.635454203069077 2.81455381573105e-08 mirMAP -0.155284428603942 8.0835303918136e-05 NA NA NA hsa-miR-590-5p PIK3R3 -0.103355559980404 0.310027295317092 0.635454203069077 2.81455381573105e-08 miRanda -0.243402254613955 1.30668545381547e-05 NA NA NA hsa-miR-624-5p PIK3R3 -0.639533773668123 6.79146620944254e-06 0.635454203069077 2.81455381573105e-08 MirTarget -0.124942360560089 0.00156005977445166 NA NA NA hsa-miR-92a-3p PIK3R3 0.212391012518195 0.134292268089997 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.21036606255577 1.06004328001549e-07 NA NA NA hsa-miR-107 PIK3R5 0.241662461253461 0.0170788899505389 -0.89989526759384 1.62789758196776e-07 miRanda -0.349504238477674 3.20976138937126e-05 NA NA NA hsa-miR-101-3p PIP4K2A -1.48176407980989 3.98950707385704e-31 -0.358701408306054 0.000429638184864051 miRNAWalker2_validate -0.118424024119889 0.00107488064793291 NA NA NA hsa-miR-101-3p PIP5K1C -1.48176407980989 3.98950707385704e-31 0.641182990319105 2.91870555906427e-13 miRNAWalker2_validate;MirTarget;miRNATAP -0.296890709951888 1.6268773863417e-22 NA NA NA hsa-miR-301a-3p PITPNM2 0.842910511640361 1.43446467417891e-06 0.252057635121367 0.0799674757736623 MirTarget;miRNATAP -0.222988117880956 1.14502549647454e-08 NA NA NA hsa-miR-195-5p PITX1 -1.85907534356434 1.47434041676402e-22 4.07775096376809 6.48992389749092e-14 mirMAP -0.596179454889552 1.06864739693947e-05 NA NA NA hsa-miR-101-3p PKNOX1 -1.48176407980989 3.98950707385704e-31 0.273261190866287 6.48784120773265e-06 miRNATAP -0.11158689921454 1.58962948771854e-07 NA NA NA hsa-miR-301a-3p PLAA 0.842910511640361 1.43446467417891e-06 -0.0928110906195583 0.208738766384737 MirTarget;miRNATAP -0.10921210546667 4.37754807508455e-08 NA NA NA hsa-miR-101-3p PLAG1 -1.48176407980989 3.98950707385704e-31 1.04276161449411 0.000370375517337123 miRNAWalker2_validate -0.492857965353428 2.01754717477225e-06 NA NA NA hsa-miR-195-5p PLAG1 -1.85907534356434 1.47434041676402e-22 1.04276161449411 0.000370375517337123 MirTarget;miRNATAP -0.48949879528453 2.35350176651651e-12 NA NA NA hsa-miR-199a-3p PLAG1 -2.3279328685682 1.04468066198593e-17 1.04276161449411 0.000370375517337123 PITA;miRNATAP -0.120678920255867 0.0173348175568722 NA NA NA hsa-let-7c-5p PLAGL2 -1.70744661345097 2.87934212005942e-20 0.336986331692996 0.00300478705110513 MirTarget -0.167081915992385 2.69511671900005e-09 NA NA NA hsa-miR-101-3p PLCG1 -1.48176407980989 3.98950707385704e-31 0.954675597841582 9.37413206548639e-17 miRNATAP -0.22440743759437 7.91378554146212e-08 NA NA NA hsa-let-7c-5p PLEKHG6 -1.70744661345097 2.87934212005942e-20 0.0255008978984725 0.925472142399852 MirTarget -0.203069992909591 0.0029441217881029 NA NA NA hsa-miR-199a-3p PLEKHH1 -2.3279328685682 1.04468066198593e-17 1.25039195218202 7.83074573807631e-12 PITA;miRNATAP -0.110450909175182 0.000592022664689198 NA NA NA hsa-miR-199a-5p PLIN5 -1.98848462405923 2.0421622713753e-11 -0.471410501154636 0.0256769570974911 miRanda -0.113642480342314 0.00076551633186093 NA NA NA hsa-miR-195-5p PLXDC1 -1.85907534356434 1.47434041676402e-22 2.83957658613902 7.43247270561304e-40 mirMAP -0.137865312131395 0.0168400652720809 NA NA NA hsa-miR-101-3p PLXNA2 -1.48176407980989 3.98950707385704e-31 0.670712916849495 3.85732284396182e-10 MirTarget;miRNATAP -0.186441038419245 1.21726556294591e-06 NA NA NA hsa-let-7c-5p PLXND1 -1.70744661345097 2.87934212005942e-20 0.69765536803745 4.01395417482674e-09 MirTarget -0.121343527002517 5.62640054248759e-05 NA NA NA hsa-miR-101-3p POGK -1.48176407980989 3.98950707385704e-31 0.625888080106357 7.94900288255434e-11 MirTarget -0.254613662927253 5.78227574626832e-14 NA NA NA hsa-miR-101-3p POGZ -1.48176407980989 3.98950707385704e-31 0.727229618149945 3.18900402177987e-14 MirTarget;miRNATAP -0.137646028422263 7.88897272534358e-05 NA NA NA hsa-miR-199a-5p POLR1A -1.98848462405923 2.0421622713753e-11 0.685972895492656 7.69671870321328e-11 mirMAP -0.109218453304887 9.7296929725248e-11 NA NA NA hsa-miR-195-5p POLR3F -1.85907534356434 1.47434041676402e-22 0.522293533187991 9.23742705455141e-15 MirTarget;miRNATAP -0.102763591051243 4.71576174813521e-10 NA NA NA hsa-miR-101-3p POLR3K -1.48176407980989 3.98950707385704e-31 0.447607095727689 2.40649278884285e-06 MirTarget -0.165446657407578 8.80307916465269e-07 NA NA NA hsa-miR-199b-5p PPARA -0.454049170125872 0.254611775331658 -0.607171871846345 3.30592576448713e-05 mirMAP -0.123098676415308 5.9954564806934e-12 NA NA NA hsa-miR-199a-5p PPARG -1.98848462405923 2.0421622713753e-11 0.325170605338307 0.0406603250248875 miRanda -0.130895577727881 1.88914901249296e-07 NA NA NA hsa-miR-199a-5p PPOX -1.98848462405923 2.0421622713753e-11 1.04089233020311 2.10328524495801e-24 miRanda -0.125952511896396 6.47258104031844e-14 NA NA NA hsa-miR-195-5p PPP1R11 -1.85907534356434 1.47434041676402e-22 0.294533680518586 7.75368954076791e-05 MirTarget;miRNATAP -0.108330416143118 1.18998237609112e-09 NA NA NA hsa-miR-301a-3p PPP1R12B 0.842910511640361 1.43446467417891e-06 -0.400775560101386 0.000211934336132358 mirMAP -0.119220878484418 6.31371894287382e-05 NA NA NA hsa-miR-101-3p PPP4R1 -1.48176407980989 3.98950707385704e-31 0.317698694530533 1.21704160581586e-05 miRNAWalker2_validate -0.165162650008096 7.24907017288583e-11 NA NA NA hsa-let-7c-5p PRAF2 -1.70744661345097 2.87934212005942e-20 0.470949457085433 4.21533714109916e-05 miRNAWalker2_validate -0.114609565008073 7.36690639861184e-05 NA NA NA hsa-miR-199a-3p PRC1 -2.3279328685682 1.04468066198593e-17 3.32083015140916 5.44951738887043e-52 MirTarget -0.280453642080944 2.16928001293243e-11 NA NA NA hsa-miR-199a-5p PRC1 -1.98848462405923 2.0421622713753e-11 3.32083015140916 5.44951738887043e-52 miRanda -0.23859422062711 1.12546525398033e-09 NA NA NA hsa-miR-15a-5p PRKAA1 0.349521211668244 0.000770735998804736 -0.60864021207068 5.26267892833978e-12 MirTarget -0.127934215917556 0.00259652352236475 NA NA NA hsa-let-7b-3p PRKAA2 -1.21979213547786 5.84575581584603e-17 0.910177606708893 0.0133266185680845 mirMAP -0.385703556647416 0.00114946510675726 NA NA NA hsa-let-7b-5p PRKAA2 -0.959013717270803 5.95127281258643e-11 0.910177606708893 0.0133266185680845 miRNAWalker2_validate;MirTarget -0.399590032732691 0.000857606952583238 NA NA NA hsa-let-7c-5p PRKAA2 -1.70744661345097 2.87934212005942e-20 0.910177606708893 0.0133266185680845 MirTarget -0.323478962357034 0.000457014156060023 NA NA NA hsa-miR-125b-5p PRKAA2 -1.35767721102906 1.16564617395164e-18 0.910177606708893 0.0133266185680845 miRNATAP -0.468131740207186 2.58447444857568e-05 NA NA NA hsa-miR-126-5p PRKAA2 -0.428561469405594 6.6035585844222e-05 0.910177606708893 0.0133266185680845 mirMAP -0.353829124273961 0.0349255565875956 NA NA NA hsa-miR-130a-3p PRKAA2 -1.53229181736223 2.91460363624872e-19 0.910177606708893 0.0133266185680845 MirTarget -0.261650172386151 0.00937218581418371 NA NA NA hsa-miR-130b-3p PRKAA2 0.687190305027546 0.000109068658562255 0.910177606708893 0.0133266185680845 MirTarget -0.39214943725483 8.93727722972995e-05 NA NA NA hsa-miR-139-5p PRKAA2 -2.11299531796557 8.16407076415038e-28 0.910177606708893 0.0133266185680845 mirMAP -0.243840459298225 0.00500077362975578 NA NA NA hsa-miR-144-3p PRKAA2 -2.97536914478815 6.00546047309683e-28 0.910177606708893 0.0133266185680845 mirMAP -0.251212728741441 4.29127796324217e-05 NA NA NA hsa-miR-16-2-3p PRKAA2 -0.0336420826463706 0.805158952566973 0.910177606708893 0.0133266185680845 mirMAP -0.457570769127741 0.000536483503983079 NA NA NA hsa-miR-195-3p PRKAA2 -1.09375690196245 4.70092324819807e-09 0.910177606708893 0.0133266185680845 mirMAP -0.528536254111941 2.17986726272341e-08 NA NA NA hsa-miR-203a-3p PRKAA2 -1.34362479226226 8.69374456831293e-05 0.910177606708893 0.0133266185680845 MirTarget -0.179382015471783 0.000540688920660811 NA NA NA hsa-miR-217 PRKAA2 1.05797297540381 0.0401026692682422 0.910177606708893 0.0133266185680845 mirMAP -0.174781811555677 3.64856315207684e-07 NA NA NA hsa-miR-22-5p PRKAA2 -0.630365901263172 3.32415348030414e-05 0.910177606708893 0.0133266185680845 mirMAP -0.407034919675641 0.000519823954254811 NA NA NA hsa-miR-26a-5p PRKAA2 -0.963792031426845 1.83360999387345e-22 0.910177606708893 0.0133266185680845 mirMAP -0.782511241662933 5.79168652076068e-06 NA NA NA hsa-miR-30e-3p PRKAA2 -1.20845647373031 3.10263633528203e-25 0.910177606708893 0.0133266185680845 MirTarget -0.527801395071765 0.000287963362506242 NA NA NA hsa-miR-30e-5p PRKAA2 -0.627815042856657 3.02205690184908e-10 0.910177606708893 0.0133266185680845 MirTarget -0.438345582649116 0.0139749918956882 NA NA NA hsa-miR-576-5p PRKAA2 -0.377452008285847 0.00470735657343984 0.910177606708893 0.0133266185680845 mirMAP -0.339109435921254 0.0119064555477781 NA NA NA hsa-miR-628-3p PRKAA2 -0.958478775877672 6.18965095549213e-08 0.910177606708893 0.0133266185680845 mirMAP -0.30159363325766 0.00298084973196401 NA NA NA hsa-miR-301a-3p PRKG1 0.842910511640361 1.43446467417891e-06 -1.38853534989461 1.21422425786253e-07 miRNATAP -0.260387081205238 0.000377008166687358 NA NA NA hsa-miR-101-3p PRR11 -1.48176407980989 3.98950707385704e-31 1.99211560684274 4.21699168750545e-09 MirTarget -0.677727534441503 2.14139273404724e-08 NA NA NA hsa-miR-301a-3p PRR5L 0.842910511640361 1.43446467417891e-06 0.340313427554474 0.141376755649448 miRNATAP -0.130303151783091 0.0414495357633103 NA NA NA hsa-let-7c-5p PRRX1 -1.70744661345097 2.87934212005942e-20 2.13747637731194 2.98162416691034e-16 MirTarget -0.352682612593982 1.66283334492681e-07 NA NA NA hsa-miR-195-5p PRX -1.85907534356434 1.47434041676402e-22 0.973700085344309 4.95602829998367e-13 mirMAP -0.133017738925599 7.09547358336385e-05 NA NA NA hsa-miR-195-5p PSKH1 -1.85907534356434 1.47434041676402e-22 0.879428894611563 3.34327921284086e-17 MirTarget;miRNATAP -0.171240980803234 2.80319845644173e-11 NA NA NA hsa-miR-301a-3p PSMA2 0.842910511640361 1.43446467417891e-06 -0.390800012363166 9.5449730317426e-07 mirMAP -0.105234462605502 1.6315170200722e-06 NA NA NA hsa-miR-195-5p PSME3 -1.85907534356434 1.47434041676402e-22 0.496626137933335 2.95522663379897e-14 MirTarget;miRNATAP -0.120136110460474 2.75618897299846e-14 NA NA NA hsa-miR-199a-5p PSMG4 -1.98848462405923 2.0421622713753e-11 0.341033466263636 0.0060889740816588 mirMAP -0.123782813398737 2.34495822002524e-10 NA NA NA hsa-let-7c-5p PTGES2 -1.70744661345097 2.87934212005942e-20 0.505915263560095 4.3460926132534e-06 miRNAWalker2_validate -0.150018737330616 5.00669169745312e-08 NA NA NA hsa-miR-301a-3p PTGR2 0.842910511640361 1.43446467417891e-06 -0.145392892673285 0.161945623836723 mirMAP -0.113109857277326 6.92700395871995e-05 NA NA NA hsa-let-7c-5p PTK2 -1.70744661345097 2.87934212005942e-20 0.592116034898139 1.42360483588582e-09 miRNAWalker2_validate -0.111526582483996 6.85487252665759e-06 NA NA NA hsa-miR-301a-3p PTP4A1 0.842910511640361 1.43446467417891e-06 -0.992339106326769 1.8359671015725e-15 miRNATAP -0.223384072780625 1.54506707200076e-10 NA NA NA hsa-miR-301a-3p PTPRM 0.842910511640361 1.43446467417891e-06 0.0121830472151929 0.941670599603893 miRNATAP -0.164067839920018 0.000325984343750748 NA NA NA hsa-miR-195-5p PWWP2B -1.85907534356434 1.47434041676402e-22 0.743363382548628 2.48073397174206e-05 MirTarget -0.133073707197914 0.00202785186080605 NA NA NA hsa-miR-195-5p PXMP4 -1.85907534356434 1.47434041676402e-22 0.626458258235179 3.75424767991764e-08 MirTarget -0.13036092169594 2.7476613994633e-06 NA NA NA hsa-miR-195-5p PYCRL -1.85907534356434 1.47434041676402e-22 0.830809890342951 7.37352070902481e-10 mirMAP -0.148569106391077 7.44384227848931e-06 NA NA NA hsa-miR-101-3p PYGO2 -1.48176407980989 3.98950707385704e-31 1.17890176614 2.86682262433208e-35 MirTarget -0.331772053647956 2.74296301686481e-21 NA NA NA hsa-miR-101-3p QSER1 -1.48176407980989 3.98950707385704e-31 0.302919834346387 0.000829170979688294 miRNAWalker2_validate -0.120632170438935 0.00017072828439011 NA NA NA hsa-miR-101-3p RAB11FIP1 -1.48176407980989 3.98950707385704e-31 0.108952592671093 0.533553281978569 miRNAWalker2_validate -0.239856446224192 0.00010260214636467 NA NA NA hsa-let-7c-5p RAB11FIP4 -1.70744661345097 2.87934212005942e-20 1.54437373311846 7.02562100479325e-17 MirTarget -0.366743712732836 4.57221998622098e-15 NA NA NA hsa-miR-301a-3p RAB14 0.842910511640361 1.43446467417891e-06 -0.618096160896154 4.4226740364116e-18 MirTarget -0.109917842001446 4.6958726200769e-08 NA NA NA hsa-miR-101-3p RAB15 -1.48176407980989 3.98950707385704e-31 0.191761348491017 0.18349645899402 MirTarget -0.279423830037542 2.98117355660265e-08 NA NA NA hsa-miR-301a-3p RAB27A 0.842910511640361 1.43446467417891e-06 -0.972374640050834 1.44144502184296e-11 mirMAP -0.122386161882664 0.00259734085312579 NA NA NA hsa-miR-301a-3p RAB30 0.842910511640361 1.43446467417891e-06 -0.688840167280648 5.94886883391515e-06 mirMAP;miRNATAP -0.162089289209003 0.00012100847934758 NA NA NA hsa-let-7c-5p RAB34 -1.70744661345097 2.87934212005942e-20 0.412870987704762 0.126202873299987 miRNAWalker2_validate -0.284015184457008 2.48793947860605e-05 NA NA NA hsa-miR-450a-5p RAB40B -1.65464197503467 7.32200902934081e-23 0.161812746226648 0.151526155897608 mirMAP -0.132187012248621 1.6900974876315e-05 NA NA NA hsa-miR-301a-3p RAB43 0.842910511640361 1.43446467417891e-06 -0.104176840320716 0.283841612828633 mirMAP -0.117779260550648 8.75994364881234e-06 NA NA NA hsa-miR-101-3p RAC1 -1.48176407980989 3.98950707385704e-31 0.216579201672401 0.00293326905874306 miRNAWalker2_validate;MirTarget -0.160619583159355 2.13421294167009e-10 25202416;24649082;25057058 In previous studies the role of miRNA-101 miR-101 in tumors has been identified as a tumor suppressor and until now the role of miR-101 and Rac1 in thyroid cancer has remained undefined; Rac1 was demonstrated to be negatively regulated by miR-101 at the post-transcriptional level via a specific target site within the 3' untranslated region by dual-luciferase reporter assay; The expression of Rac1 was also observed to inversely correlate with miR-101 expression in PTC tissues; knockdown of Rac1 by shRNA inhibited thyroid cancer cell migration and invasion resembling that of miR-101 overexpression; Thus these findings suggested that miR-101 acts as a novel suppressor by targeting the Rac1 gene and inhibiting thyroid cancer cell migration and invasion;miR 101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma; In the present study we investigated the role of microRNA-101 miR-101 in PTC via targeting of Ras-related C3 botulinum toxin substrate 1 Rac1; Moreover algorithm-based and experimental strategies verified Rac1 as a direct target of miR-101 in the K1 cell line; Taken together these findings suggest that miR-101 inhibited PTC growth via the downregulation of Rac1 expression providing a better understanding of miRNA-modulated signaling networks for future cancer therapeutics;Mir-101 inhibitors significantly increased the luciferase activities of RAC1 3'UTR; Overexpression of mir-101 increased the expression of RAC1 while inhibition of mir-101 suppressed RAC1 expression; mir-101 can suppress RAC1 gene expression by targeting the specific sequence of RAC1 3'UTR cell migration;; thyroid cancer;thyroid cancer;colorectal cancer hsa-let-7c-5p RAD18 -1.70744661345097 2.87934212005942e-20 0.734804507433037 1.25694117049507e-15 MirTarget -0.162229147179546 3.03633151346655e-12 NA NA NA hsa-miR-199a-5p RAD51C -1.98848462405923 2.0421622713753e-11 0.629557746558908 5.35046596495962e-11 miRanda -0.100717229638272 5.28079337701813e-11 NA NA NA hsa-miR-195-5p RAD9A -1.85907534356434 1.47434041676402e-22 0.953005845945273 1.55158300757576e-19 miRNATAP -0.178643219982651 8.11691894656275e-12 NA NA NA hsa-miR-301a-3p RAG1 0.842910511640361 1.43446467417891e-06 -1.83334993331865 5.88133623260973e-11 miRNATAP -0.401929293313222 2.74880643174895e-07 NA NA NA hsa-miR-101-3p RAP1GAP2 -1.48176407980989 3.98950707385704e-31 -0.150407243792527 0.591682167346389 mirMAP -0.53936728301742 3.86567214812244e-08 NA NA NA hsa-miR-301a-3p RAPGEF3 0.842910511640361 1.43446467417891e-06 0.817125994246768 4.45573187890538e-08 mirMAP -0.149427913622576 0.00033590962233435 NA NA NA hsa-miR-301a-3p RAPGEF4 0.842910511640361 1.43446467417891e-06 -1.07075647385906 1.41124137066171e-09 MirTarget;miRNATAP -0.25159655587852 3.12317018964775e-07 NA NA NA hsa-let-7c-5p RAPGEFL1 -1.70744661345097 2.87934212005942e-20 0.512757940233236 0.00610377319567469 miRNAWalker2_validate -0.104672283482989 0.0263816556863234 NA NA NA hsa-miR-101-3p RASA4 -1.48176407980989 3.98950707385704e-31 0.399517189809353 0.0293965025033579 mirMAP -0.178029432560402 0.00631900279012344 NA NA NA hsa-miR-301a-3p RASD1 0.842910511640361 1.43446467417891e-06 -1.80141635813111 2.33478853508858e-09 MirTarget -0.406303499452816 1.32723530365263e-06 NA NA NA hsa-miR-101-3p RASD2 -1.48176407980989 3.98950707385704e-31 2.400731696963 9.88874890802875e-33 MirTarget;miRNATAP -0.699535699928572 2.94176160943532e-21 NA NA NA hsa-miR-301a-3p RASGEF1B 0.842910511640361 1.43446467417891e-06 -2.40154618069155 1.29739869332177e-25 mirMAP -0.414986882004829 3.42342782317223e-10 NA NA NA hsa-miR-195-5p RASGRF1 -1.85907534356434 1.47434041676402e-22 1.49106370660108 5.96975990261592e-05 mirMAP -0.26382335869635 0.00370723355782595 NA NA NA hsa-miR-101-3p RASGRP3 -1.48176407980989 3.98950707385704e-31 0.366240287028941 0.0112314371168442 MirTarget -0.143683044248925 0.00513809938410704 NA NA NA hsa-miR-199b-5p RASL10B -0.454049170125872 0.254611775331658 -0.789585419723034 0.076815885374372 mirMAP -0.222403490732244 5.64504003201025e-05 NA NA NA hsa-miR-101-3p RBBP7 -1.48176407980989 3.98950707385704e-31 0.502046612529977 6.46813371549665e-13 MirTarget;miRNATAP -0.171312787295 4.52159680418142e-12 NA NA NA hsa-miR-199a-5p RBM24 -1.98848462405923 2.0421622713753e-11 1.89188345491287 3.06626255996883e-11 miRanda;miRNATAP -0.262319063374466 1.19622403640637e-08 NA NA NA hsa-miR-199b-5p RBM24 -0.454049170125872 0.254611775331658 1.89188345491287 3.06626255996883e-11 miRanda -0.143292102080044 7.24429754932495e-05 NA NA NA hsa-miR-301a-3p RBMS3 0.842910511640361 1.43446467417891e-06 -1.89502188938102 2.39783861807597e-18 mirMAP -0.278540557081986 6.9695381730278e-06 NA NA NA hsa-miR-199a-5p RCCD1 -1.98848462405923 2.0421622713753e-11 0.679741680660072 5.40279166644907e-14 miRanda -0.116200599048298 6.21584521190193e-16 NA NA NA hsa-miR-101-3p RCN2 -1.48176407980989 3.98950707385704e-31 0.702225807365378 7.57876878361327e-13 MirTarget -0.244250381819765 2.3200138074077e-12 NA NA NA hsa-miR-101-3p RCOR3 -1.48176407980989 3.98950707385704e-31 0.682612110290905 2.57158341609511e-13 miRNATAP -0.128084705504576 0.00015767592430349 NA NA NA hsa-miR-195-5p RCOR3 -1.85907534356434 1.47434041676402e-22 0.682612110290905 2.57158341609511e-13 MirTarget;miRNATAP -0.101733498210241 1.06776276187547e-05 NA NA NA hsa-miR-101-3p RFPL4B -1.48176407980989 3.98950707385704e-31 2.07048958949685 4.11880057142348e-05 MirTarget -0.472836578748367 0.00899092965281252 NA NA NA hsa-miR-195-5p RFWD2 -1.85907534356434 1.47434041676402e-22 0.633010495593122 4.7570127100633e-15 MirTarget -0.105545894540319 1.26177871904194e-07 NA NA NA hsa-let-7c-5p RFWD3 -1.70744661345097 2.87934212005942e-20 0.435632342748586 1.3132101658858e-06 miRNAWalker2_validate -0.125524002210606 2.35908018598628e-08 NA NA NA hsa-let-7c-5p RFX5 -1.70744661345097 2.87934212005942e-20 1.21360829628678 2.49921334600813e-28 MirTarget -0.142572635491316 1.08560294572442e-06 NA NA NA hsa-miR-101-3p RGS1 -1.48176407980989 3.98950707385704e-31 -1.11602832462022 0.000153399959122597 miRNATAP -0.35708682303864 0.000688122020495588 NA NA NA hsa-miR-542-3p RHEB -1.31351015149842 3.64642423288576e-22 0.594343190335174 8.4076096236034e-15 miRanda -0.154397416399753 5.84623305682461e-09 NA NA NA hsa-miR-199a-5p RHEBL1 -1.98848462405923 2.0421622713753e-11 1.4822269050808 5.27910865253226e-17 miRanda -0.137424244180682 2.48030133452328e-06 NA NA NA hsa-miR-301a-3p RHOBTB3 0.842910511640361 1.43446467417891e-06 -0.211879366931202 0.161947420887018 mirMAP -0.118535563065561 0.00447239194691322 NA NA NA hsa-miR-140-3p RICTOR 0.546012239205329 4.84578261098777e-11 -0.237765548278541 0.0047022112792698 MirTarget;PITA;miRNATAP -0.120225620055793 0.014083109922705 NA NA NA hsa-miR-16-1-3p RICTOR 0.392360028038559 0.00112481918108198 -0.237765548278541 0.0047022112792698 MirTarget -0.107553049046612 0.00155488864096036 NA NA NA hsa-miR-660-5p RICTOR 0.989755850734071 5.69930767464937e-14 -0.237765548278541 0.0047022112792698 MirTarget -0.124145467768421 3.66585982170959e-05 NA NA NA hsa-miR-301a-3p RNF125 0.842910511640361 1.43446467417891e-06 -2.35285580520537 6.18394766308694e-26 mirMAP -0.550360392965685 2.42444842302833e-18 NA NA NA hsa-miR-301a-3p RNF152 0.842910511640361 1.43446467417891e-06 -1.99846276106589 3.29375349002461e-27 mirMAP -0.358139973282056 1.79961766866689e-11 NA NA NA hsa-miR-301a-3p RNF165 0.842910511640361 1.43446467417891e-06 -3.06109685929762 4.74971186974903e-22 miRNATAP -0.254494656943053 0.00578180888337783 NA NA NA hsa-miR-199a-5p RNF17 -1.98848462405923 2.0421622713753e-11 0.71912202317723 0.0563459510120398 miRanda -0.142237166017745 0.0185766473962654 NA NA NA hsa-miR-195-5p RNF43 -1.85907534356434 1.47434041676402e-22 0.784493664430453 0.00195272247858492 MirTarget;miRNATAP -0.369484443565591 1.13835027412277e-09 NA NA NA hsa-miR-101-3p RNF44 -1.48176407980989 3.98950707385704e-31 0.663587868143992 1.70848468031349e-11 miRNAWalker2_validate;miRNATAP -0.256069752077661 1.96625214238963e-13 NA NA NA hsa-miR-450a-5p RNFT2 -1.65464197503467 7.32200902934081e-23 2.1297470763973 7.49430405487591e-18 mirMAP -0.188614663655874 0.00784918055944698 NA NA NA hsa-miR-195-5p RPL10 -1.85907534356434 1.47434041676402e-22 0.301229036500462 0.00323041421615768 miRNAWalker2_validate -0.118856995213518 1.38305062717624e-06 NA NA NA hsa-let-7c-5p RPL18A -1.70744661345097 2.87934212005942e-20 0.302238061682566 0.0189119255010824 miRNAWalker2_validate -0.183702992224943 7.94319049679231e-09 NA NA NA hsa-miR-199a-5p RPL36A -1.98848462405923 2.0421622713753e-11 1.6674642742218 9.30020984679361e-14 miRanda -0.13344116272508 0.000289869642108993 NA NA NA hsa-let-7c-5p RPS13 -1.70744661345097 2.87934212005942e-20 0.0402954151984805 0.688921058276665 miRNAWalker2_validate -0.10218446432348 4.42586947280731e-05 NA NA NA hsa-let-7c-5p RPS24 -1.70744661345097 2.87934212005942e-20 0.267883090577552 0.0468033270606586 miRNAWalker2_validate -0.196549606512263 3.44029551262791e-09 NA NA NA hsa-miR-99a-5p RPS6 -1.51481656384839 3.93230057259529e-14 0.185885010447493 0.120916808338817 miRNAWalker2_validate -0.141086052819295 4.22214050226356e-07 NA NA NA hsa-miR-17-5p RPS6KA1 0.698861147045461 2.43854106455398e-05 -0.0193982843076919 0.895272926505225 TargetScan;miRNATAP -0.150479492101603 0.000442310908893647 NA NA NA hsa-miR-20a-5p RPS6KA1 0.854326758727003 5.04256669663285e-07 -0.0193982843076919 0.895272926505225 miRNATAP -0.140420093444226 0.000724052018701145 NA NA NA hsa-miR-130b-5p RPS6KA2 0.170599813152408 0.337611586432771 -0.429936688183553 0.00940192295734202 mirMAP -0.213305958673466 2.2886761501014e-06 NA NA NA hsa-miR-17-5p RPS6KA2 0.698861147045461 2.43854106455398e-05 -0.429936688183553 0.00940192295734202 TargetScan -0.361293542462631 1.51868565926867e-14 NA NA NA hsa-miR-192-3p RPS6KA2 -0.6401165114007 0.000266272092403814 -0.429936688183553 0.00940192295734202 mirMAP -0.190995022600123 2.73504188366536e-05 NA NA NA hsa-miR-193a-3p RPS6KA2 -0.117675551589896 0.309391958208578 -0.429936688183553 0.00940192295734202 mirMAP -0.302358304666807 1.53272294304117e-05 NA NA NA hsa-miR-19a-3p RPS6KA2 1.01712596153672 2.57753201450625e-07 -0.429936688183553 0.00940192295734202 MirTarget -0.190446066307176 1.94564659739969e-06 NA NA NA hsa-miR-19b-3p RPS6KA2 0.601279551368824 0.00016685097085251 -0.429936688183553 0.00940192295734202 MirTarget -0.235922153431053 2.30069900396003e-06 NA NA NA hsa-miR-30d-5p RPS6KA2 0.718283816348023 2.47422074061352e-08 -0.429936688183553 0.00940192295734202 MirTarget;miRNATAP -0.222191844967225 0.000323873436695374 NA NA NA hsa-miR-3127-5p RPS6KA2 0.837385386388614 2.06679743975142e-07 -0.429936688183553 0.00940192295734202 mirMAP -0.204709957034024 3.28185871635773e-05 NA NA NA hsa-miR-532-3p RPS6KA2 0.297601533259956 0.014632205884815 -0.429936688183553 0.00940192295734202 MirTarget;mirMAP -0.296357914442727 7.3133532891582e-06 NA NA NA hsa-miR-589-5p RPS6KA2 1.18593770505086 1.01781241960531e-22 -0.429936688183553 0.00940192295734202 mirMAP -0.412829583412935 3.43368368308291e-11 NA NA NA hsa-miR-93-3p RPS6KA2 0.402821129107592 0.00131324842735588 -0.429936688183553 0.00940192295734202 MirTarget -0.482383363283909 1.2839051401815e-14 NA NA NA hsa-miR-181c-5p RPS6KA3 -0.00639394152050299 0.969127212255928 -0.0721830047612428 0.620235959053163 MirTarget;mirMAP;miRNATAP -0.132982978659169 0.00196775794236537 NA NA NA hsa-miR-497-5p RPS6KA3 -1.41371173021948 7.09278946477743e-17 -0.0721830047612428 0.620235959053163 MirTarget;miRNATAP -0.106167734324023 0.00837538561255109 NA NA NA hsa-miR-126-5p RPS6KB1 -0.428561469405594 6.6035585844222e-05 0.0405513114293425 0.579068505304799 mirMAP -0.106946073918378 0.00114467289374143 NA NA NA hsa-miR-145-5p RPS6KB1 -1.4795885711477 6.47308361543414e-16 0.0405513114293425 0.579068505304799 MirTarget;miRNATAP -0.109724019103871 2.07298188703538e-09 24157791 MiR 145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1; MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3'UTRs; Importantly the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145 respectively; Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1 functioning as a tumor suppressor ovarian cancer hsa-miR-181a-5p RPS6KB1 0.250113435902954 0.0551933249319293 0.0405513114293425 0.579068505304799 MirTarget;miRNATAP -0.116671963226395 1.5972465565874e-05 NA NA NA hsa-miR-181c-5p RPS6KB1 -0.00639394152050299 0.969127212255928 0.0405513114293425 0.579068505304799 MirTarget;miRNATAP -0.10835890138279 3.360156885851e-07 NA NA NA hsa-miR-27a-3p RPS6KB1 -0.370807380415112 0.00875721956202713 0.0405513114293425 0.579068505304799 MirTarget;miRNATAP -0.13716383977936 2.72226167197111e-08 NA NA NA hsa-miR-342-3p RPS6KB1 -0.319677314984262 0.0449813878317147 0.0405513114293425 0.579068505304799 miRanda -0.115090266357129 1.55784431831661e-07 NA NA NA hsa-miR-542-3p RPS6KB1 -1.31351015149842 3.64642423288576e-22 0.0405513114293425 0.579068505304799 miRNATAP -0.102388373747613 3.28524227017976e-05 NA NA NA hsa-miR-125a-5p RPS6KB2 -0.91219969372382 1.38256246489548e-07 0.230775242252044 0.00570601482278892 miRanda -0.115997614156545 4.04919339586598e-07 NA NA NA hsa-miR-195-5p RPS6KL1 -1.85907534356434 1.47434041676402e-22 1.9197850094522 6.91159342435759e-17 mirMAP -0.196085273184256 0.00071481494193207 NA NA NA hsa-miR-195-5p RPUSD1 -1.85907534356434 1.47434041676402e-22 0.656610706544838 1.1310320311173e-11 mirMAP -0.109277306761911 4.51399924990821e-06 NA NA NA hsa-miR-199a-5p RRAGD -1.98848462405923 2.0421622713753e-11 0.728091057482102 3.93159084114385e-05 miRanda -0.110818768534455 9.70584654893004e-05 NA NA NA hsa-miR-101-3p RRM1 -1.48176407980989 3.98950707385704e-31 0.577708398391279 6.74096739602722e-10 MirTarget;miRNATAP -0.139621581321354 3.30672558338072e-05 NA NA NA hsa-miR-199a-5p RRM2 -1.98848462405923 2.0421622713753e-11 3.28040567179396 1.92251546747087e-44 miRanda -0.287593523150928 2.03574804917786e-12 NA NA NA hsa-miR-199b-5p RSPO2 -0.454049170125872 0.254611775331658 -1.47503442551075 0.000466618278395286 miRanda -0.174597330313447 0.000905436029618973 NA NA NA hsa-miR-199a-5p RTKN2 -1.98848462405923 2.0421622713753e-11 2.57925113894623 4.76198655776531e-18 miRanda -0.111897729046846 0.0246972975316379 NA NA NA hsa-miR-101-3p RUNX1 -1.48176407980989 3.98950707385704e-31 -0.00485952026487979 0.975956818735336 miRNATAP -0.284524982567448 4.80934677396681e-07 26628987 Mechanistically we indicated that miR-101 inversely correlated with RUNX1 expression and identified RUNX1 as a novel target of miR-101; RUNX1 impaired the effects of miR-101 on chemotherapeutic sensitization and invasion inhibition; These findings support that miR-101 downregulation accelerates the progression of lung cancer via RUNX1 dependent manner and suggest that miR-101/RUNX1 feedback axis may have therapeutic value in treating refractory lung cancer progression lung cancer hsa-miR-301a-3p S1PR1 0.842910511640361 1.43446467417891e-06 -0.723869489322336 1.31811287279409e-06 MirTarget;miRNATAP -0.298012565473695 2.13125738082782e-13 NA NA NA hsa-miR-195-5p SAMD10 -1.85907534356434 1.47434041676402e-22 0.872932422756584 1.87788574518353e-13 MirTarget -0.239117680897168 5.76395814855946e-17 NA NA NA hsa-miR-301a-3p SAMHD1 0.842910511640361 1.43446467417891e-06 -0.219855252528804 0.21059107396466 mirMAP -0.189097920879893 8.53556387534501e-05 NA NA NA hsa-miR-301a-3p SAR1B 0.842910511640361 1.43446467417891e-06 -0.602691569549908 4.60715859176311e-06 MirTarget -0.320734217104327 4.96198607787186e-20 NA NA NA hsa-miR-301a-3p SASH1 0.842910511640361 1.43446467417891e-06 -0.641621637334084 3.36245859697969e-07 MirTarget;miRNATAP -0.198876665489236 8.76923536498791e-09 NA NA NA hsa-miR-195-5p SCAMP5 -1.85907534356434 1.47434041676402e-22 1.15748731177796 2.77268937994084e-07 mirMAP -0.128451175126151 0.0207446599095557 NA NA NA hsa-miR-199a-3p SCD -2.3279328685682 1.04468066198593e-17 -0.23960201269186 0.387988088797976 MirTarget;PITA;miRNATAP -0.156914356528907 0.000971436683306992 NA NA NA hsa-miR-199a-3p SDC2 -2.3279328685682 1.04468066198593e-17 -0.03087902282995 0.814769949243076 MirTarget;PITA -0.115511834924422 2.30598186773853e-07 NA NA NA hsa-miR-301a-3p SDC4 0.842910511640361 1.43446467417891e-06 -1.18352065496432 6.93834154336227e-16 MirTarget -0.153056005484411 0.000246708748625281 NA NA NA hsa-miR-301a-3p SECISBP2L 0.842910511640361 1.43446467417891e-06 -0.667333440401773 2.01668926681874e-07 MirTarget -0.172647526693 1.16594143024759e-06 NA NA NA hsa-miR-301a-3p SEL1L 0.842910511640361 1.43446467417891e-06 -0.497073293564348 3.72339072858383e-06 mirMAP -0.172366294826028 4.58773692704436e-09 NA NA NA hsa-miR-199a-5p SELENBP1 -1.98848462405923 2.0421622713753e-11 -0.752133570152979 0.000377719655530476 miRanda -0.102775677807217 0.00251474262683157 NA NA NA hsa-let-7c-5p SEMA3F -1.70744661345097 2.87934212005942e-20 1.45777080905473 1.56816209923569e-37 MirTarget -0.234818872817101 1.05143991596871e-14 NA NA NA hsa-let-7c-5p SEMA4F -1.70744661345097 2.87934212005942e-20 1.01208582172754 6.47089148904579e-05 MirTarget -0.273087481441457 1.81190606874631e-05 NA NA NA hsa-miR-195-5p SEMA5B -1.85907534356434 1.47434041676402e-22 2.17547526596525 2.66519103986908e-30 MirTarget -0.138066709435424 0.00550115510222782 NA NA NA hsa-miR-195-5p SEMA7A -1.85907534356434 1.47434041676402e-22 1.19314988680133 1.05996526123706e-06 mirMAP -0.198331571814585 0.000947477066061984 NA NA NA hsa-miR-301a-3p SERINC3 0.842910511640361 1.43446467417891e-06 -0.331460551281738 5.22316177237787e-05 MirTarget -0.157870393154001 8.81676507086477e-13 NA NA NA hsa-miR-301a-3p SESN3 0.842910511640361 1.43446467417891e-06 -0.821541570789657 0.00383798636487833 mirMAP -0.313818250031627 6.02567843002784e-05 NA NA NA hsa-let-7c-5p SF3B4 -1.70744661345097 2.87934212005942e-20 1.02312871885638 7.99127216761014e-26 miRNAWalker2_validate -0.218936273994718 1.52946844995903e-18 NA NA NA hsa-miR-195-5p SFT2D3 -1.85907534356434 1.47434041676402e-22 0.352261169545839 5.22185267081055e-05 MirTarget -0.10079212960644 1.64883614773651e-06 NA NA NA hsa-miR-301a-3p SH3D19 0.842910511640361 1.43446467417891e-06 -0.821482116094042 8.83871291011707e-11 MirTarget;miRNATAP -0.307207108441274 2.52319108227635e-19 NA NA NA hsa-miR-199a-5p SH3RF2 -1.98848462405923 2.0421622713753e-11 0.279560747455942 0.242543606773245 miRanda -0.222913501825641 3.12688309206525e-09 NA NA NA hsa-miR-199b-5p SH3RF2 -0.454049170125872 0.254611775331658 0.279560747455942 0.242543606773245 miRanda -0.19318133436659 3.04836511718843e-11 NA NA NA hsa-miR-301a-3p SHANK2 0.842910511640361 1.43446467417891e-06 0.0332648665683903 0.871563208301543 MirTarget;miRNATAP -0.127077842667746 0.0250382729577382 NA NA NA hsa-miR-301a-3p SIK1 0.842910511640361 1.43446467417891e-06 -1.56281900212212 2.20390485809155e-13 MirTarget;miRNATAP -0.35722553772007 1.94231937355534e-09 NA NA NA hsa-miR-195-5p SIRT4 -1.85907534356434 1.47434041676402e-22 0.358155299054607 0.00343025114117995 MirTarget -0.167126992910483 1.21123596346576e-08 NA NA NA hsa-miR-101-3p SIX4 -1.48176407980989 3.98950707385704e-31 2.61579593202535 2.3706138390953e-15 miRNATAP -0.897094928504613 2.89014162353358e-14 NA NA NA hsa-miR-195-5p SIX4 -1.85907534356434 1.47434041676402e-22 2.61579593202535 2.3706138390953e-15 miRNATAP -0.465488049414048 1.31581167470065e-08 NA NA NA hsa-let-7c-5p SLC10A3 -1.70744661345097 2.87934212005942e-20 0.351752502448654 0.00188986179930041 miRNAWalker2_validate -0.182712057163013 5.67345250226885e-11 NA NA NA hsa-miR-101-3p SLC12A2 -1.48176407980989 3.98950707385704e-31 -0.491172071796036 0.0265051390992754 MirTarget;miRNATAP -0.268622855005506 0.000623755258256624 NA NA NA hsa-miR-199a-5p SLC16A1 -1.98848462405923 2.0421622713753e-11 -0.900329370707164 1.1371277256877e-06 miRanda -0.15795021834544 9.40755909599178e-08 NA NA NA hsa-miR-199b-5p SLC16A1 -0.454049170125872 0.254611775331658 -0.900329370707164 1.1371277256877e-06 miRanda -0.199805862407469 3.2644613428137e-19 NA NA NA hsa-miR-199a-3p SLC16A12 -2.3279328685682 1.04468066198593e-17 -0.582701560249782 0.124002938826254 MirTarget -0.233156647326153 0.000329208723212795 NA NA NA hsa-miR-199b-5p SLC16A2 -0.454049170125872 0.254611775331658 -1.72029553621989 7.69802544223928e-14 miRanda -0.108700391405063 0.000219249559135068 NA NA NA hsa-let-7c-5p SLC17A9 -1.70744661345097 2.87934212005942e-20 0.51327413401667 0.00962042525885391 MirTarget -0.198870581493571 6.13429852972486e-05 NA NA NA hsa-miR-199a-3p SLC1A2 -2.3279328685682 1.04468066198593e-17 -2.05184743338733 5.07102901300161e-06 PITA -0.226798871130317 0.00370756984748851 NA NA NA hsa-miR-301a-3p SLC1A2 0.842910511640361 1.43446467417891e-06 -2.05184743338733 5.07102901300161e-06 mirMAP -0.776304986306191 2.79117064833541e-10 NA NA NA hsa-miR-195-5p SLC22A23 -1.85907534356434 1.47434041676402e-22 0.632125395741205 5.61389746801226e-07 mirMAP -0.220599662241838 2.78518963479599e-13 NA NA NA hsa-miR-199b-5p SLC22A3 -0.454049170125872 0.254611775331658 -1.9854213857181 3.33178978711179e-12 miRanda -0.173101595235152 1.61852039910308e-06 NA NA NA hsa-miR-199a-5p SLC22A4 -1.98848462405923 2.0421622713753e-11 1.10791605313628 7.21707753732095e-06 miRanda -0.165854816138484 2.92416516794269e-05 NA NA NA hsa-miR-199b-5p SLC22A9 -0.454049170125872 0.254611775331658 -0.710435759279632 0.0266606545496166 miRanda -0.117303749153148 0.00327031471509888 NA NA NA hsa-miR-101-3p SLC25A3 -1.48176407980989 3.98950707385704e-31 0.201578949478213 0.00820728396315633 miRNATAP -0.105329254485003 8.85145096738858e-05 NA NA NA hsa-miR-199b-5p SLC2A4 -0.454049170125872 0.254611775331658 -0.000620280921127536 0.998114091638356 miRanda;miRNATAP -0.146611846836176 5.73360487721829e-06 NA NA NA hsa-miR-199a-5p SLC2A4RG -1.98848462405923 2.0421622713753e-11 -0.0562864028265855 0.646618084154118 miRanda -0.107145474029675 2.87790575627048e-08 NA NA NA hsa-miR-301a-3p SLC35D1 0.842910511640361 1.43446467417891e-06 -1.52905192038684 6.67856673208906e-27 MirTarget -0.368170674936279 3.59865711984073e-20 NA NA NA hsa-miR-195-5p SLC35E2B -1.85907534356434 1.47434041676402e-22 0.54117466879242 4.51042727609379e-08 mirMAP -0.153883387482594 1.11010030230627e-10 NA NA NA hsa-miR-195-5p SLC36A1 -1.85907534356434 1.47434041676402e-22 1.00108743458475 1.1038952891858e-17 MirTarget;miRNATAP -0.139076911557988 2.02558471153635e-06 NA NA NA hsa-miR-101-3p SLC39A10 -1.48176407980989 3.98950707385704e-31 1.03363681046182 2.86152302488301e-10 miRNATAP -0.54400762430038 6.74134880765429e-22 NA NA NA hsa-miR-195-5p SLC39A13 -1.85907534356434 1.47434041676402e-22 0.702545531021421 5.82346425244418e-19 mirMAP -0.109218310358272 2.89291705922213e-08 NA NA NA hsa-miR-199a-5p SLC45A2 -1.98848462405923 2.0421622713753e-11 0.761587891751687 0.0323852466852362 miRanda -0.30558795019358 5.69831933354781e-08 NA NA NA hsa-miR-199b-5p SLC45A2 -0.454049170125872 0.254611775331658 0.761587891751687 0.0323852466852362 miRanda -0.22858063180371 1.7983208271228e-07 NA NA NA hsa-miR-301a-3p SLC8A1 0.842910511640361 1.43446467417891e-06 -1.67234164835265 3.98185932744172e-20 MirTarget -0.172781889683231 0.00100307693015005 NA NA NA hsa-miR-301a-3p SLIT3 0.842910511640361 1.43446467417891e-06 0.157466553388729 0.504736595264199 mirMAP -0.170610303751472 0.00869316401828249 NA NA NA hsa-miR-101-3p SMARCA4 -1.48176407980989 3.98950707385704e-31 0.939839733482938 1.32567927001134e-26 MirTarget;miRNATAP -0.312535828514739 3.51081559877602e-23 NA NA NA hsa-let-7c-5p SMARCC1 -1.70744661345097 2.87934212005942e-20 0.453331771984192 2.34444535272705e-08 miRNAWalker2_validate -0.12781175289705 2.68001045795896e-10 NA NA NA hsa-let-7c-5p SMARCD1 -1.70744661345097 2.87934212005942e-20 0.643238619401545 1.43047276243426e-17 miRNAWalker2_validate -0.177640467487771 1.94594245173065e-21 NA NA NA hsa-miR-101-3p SMARCD1 -1.48176407980989 3.98950707385704e-31 0.643238619401545 1.43047276243426e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.27081635654554 4.35077985158985e-25 NA NA NA hsa-let-7c-5p SMCR8 -1.70744661345097 2.87934212005942e-20 0.453242799658724 3.50739679214307e-06 MirTarget -0.122565100231006 5.4902514084137e-07 NA NA NA hsa-miR-301a-3p SMOC1 0.842910511640361 1.43446467417891e-06 -1.10707795985523 6.87629157252617e-09 miRNATAP -0.201688457067717 0.000159769105566619 NA NA NA hsa-miR-199b-5p SMPX -0.454049170125872 0.254611775331658 2.12837305489447 9.48507006546033e-07 miRanda -0.175647075100253 0.00129457844808663 NA NA NA hsa-miR-199a-5p SMYD2 -1.98848462405923 2.0421622713753e-11 0.777535528256749 1.97197779075275e-08 miRanda -0.133128443210696 1.80023027504427e-09 NA NA NA hsa-miR-195-5p SMYD5 -1.85907534356434 1.47434041676402e-22 0.703671663920377 2.08776880698013e-14 miRNATAP -0.184672349685105 8.67735351478196e-17 NA NA NA hsa-miR-301a-3p SNIP1 0.842910511640361 1.43446467417891e-06 -0.465957987323868 2.0042867517773e-07 MirTarget;miRNATAP -0.108955466027839 1.11454871823754e-05 NA NA NA hsa-miR-101-3p SNN -1.48176407980989 3.98950707385704e-31 0.139978056935726 0.1435877993436 miRNATAP -0.121445047215575 0.000320545693829787 NA NA NA hsa-miR-195-5p SNX8 -1.85907534356434 1.47434041676402e-22 0.652527470677649 4.69592450906883e-10 mirMAP -0.131524118790709 2.87245448423983e-07 NA NA NA hsa-miR-101-3p SOAT1 -1.48176407980989 3.98950707385704e-31 -0.0648381834249045 0.544577902932084 MirTarget -0.171546548062424 4.91743634141444e-06 NA NA NA hsa-miR-199b-5p SOD1 -0.454049170125872 0.254611775331658 -0.85352210397156 1.1561981447329e-08 miRanda -0.133559979977693 4.02588434231327e-13 NA NA NA hsa-miR-101-3p SOX11 -1.48176407980989 3.98950707385704e-31 1.40787252269122 1.13853242912301e-05 miRNATAP -1.1026672959478 3.98583755143377e-24 NA NA NA hsa-miR-199a-5p SOX12 -1.98848462405923 2.0421622713753e-11 1.13902221223852 8.89966671522395e-12 miRanda -0.137255821461619 4.09258551201e-07 NA NA NA hsa-let-7c-5p SOX13 -1.70744661345097 2.87934212005942e-20 0.713864896374115 5.5028190432502e-13 MirTarget -0.124273877815759 8.64473078600962e-07 NA NA NA hsa-miR-301a-3p SOX5 0.842910511640361 1.43446467417891e-06 -1.35870465626211 3.34572839723252e-09 miRNATAP -0.209914519951759 0.00112584433314218 NA NA NA hsa-miR-101-3p SOX9 -1.48176407980989 3.98950707385704e-31 0.456898781063352 0.178110113816873 miRNAWalker2_validate;miRNATAP -0.924442976530542 2.21450129261226e-15 23178713 Ectopic expression of miR-101 significantly inhibited HCC cell proliferation and tumorigenicity by targeting SOX9; Therefore miR-101 may suppress HCC tumor progression by down-regulating SOX9 progression liver cancer hsa-miR-199a-3p SP6 -2.3279328685682 1.04468066198593e-17 2.23551885984922 1.02825725864058e-20 miRNATAP -0.116108790551417 0.00729718895659468 NA NA NA hsa-miR-101-3p SPATS2L -1.48176407980989 3.98950707385704e-31 0.0569396803956135 0.520259473258162 MirTarget -0.132951408136923 1.88659820332053e-05 NA NA NA hsa-miR-199a-5p SPDYE8P -1.98848462405923 2.0421622713753e-11 0.252016872934326 0.0547888399943786 miRanda -0.103585301378151 6.05673995641826e-07 NA NA NA hsa-miR-301a-3p SPG20 0.842910511640361 1.43446467417891e-06 -2.0188037720553 2.56848033710916e-20 miRNATAP -0.213459279982969 0.000718581696412727 NA NA NA hsa-miR-101-3p SPRED1 -1.48176407980989 3.98950707385704e-31 -0.584055575592488 6.88990777515141e-05 miRNATAP -0.128553733762792 0.0143729970358186 NA NA NA hsa-miR-301a-3p SPTBN1 0.842910511640361 1.43446467417891e-06 -0.250283152711688 0.00940857797743743 mirMAP -0.130986119483293 6.19002645885036e-07 NA NA NA hsa-miR-195-5p SRC -1.85907534356434 1.47434041676402e-22 0.766173851969095 0.000257254769528933 mirMAP -0.291201965854594 7.75311466804379e-09 NA NA NA hsa-miR-195-5p SRPK1 -1.85907534356434 1.47434041676402e-22 0.546430300806312 9.51704538407861e-09 miRNATAP -0.205097337503704 6.03767767652078e-20 NA NA NA hsa-miR-101-3p SRPK2 -1.48176407980989 3.98950707385704e-31 0.268687818925416 0.00309190576989384 MirTarget;miRNATAP -0.148100662493902 3.63709755062411e-06 NA NA NA hsa-miR-199b-5p SS18L1 -0.454049170125872 0.254611775331658 -0.296492401776284 0.0220761965048876 miRanda -0.119508321440582 2.01022975933702e-14 NA NA NA hsa-miR-101-3p SSBP2 -1.48176407980989 3.98950707385704e-31 -0.124114637043314 0.588013472488598 MirTarget -0.460785807024248 8.47912442904872e-09 NA NA NA hsa-miR-199a-3p SSX1 -2.3279328685682 1.04468066198593e-17 3.68205023967891 8.21303266394587e-08 miRNATAP -0.644265913343276 5.25312771958135e-08 NA NA NA hsa-miR-301a-3p ST3GAL1 0.842910511640361 1.43446467417891e-06 -0.767532914178657 6.27233158530294e-05 mirMAP -0.365567900191673 1.99594416475051e-12 NA NA NA hsa-miR-301a-3p ST6GALNAC3 0.842910511640361 1.43446467417891e-06 -1.04258541098903 2.10396558808448e-09 mirMAP -0.359327325437493 3.88331418598495e-14 NA NA NA hsa-miR-101-3p STAU2 -1.48176407980989 3.98950707385704e-31 0.314682938564168 0.000347568895305886 MirTarget -0.108408405891874 0.000515297872293064 NA NA NA hsa-miR-101-3p STC1 -1.48176407980989 3.98950707385704e-31 1.1939080061533 1.49954780653484e-08 miRNATAP -0.229282886855314 0.00259597591904522 NA NA NA hsa-miR-199a-5p STEAP2 -1.98848462405923 2.0421622713753e-11 -0.3879919292867 0.277011129421725 miRanda -0.139251193973476 0.0147979272434123 NA NA NA hsa-miR-301a-3p STEAP4 0.842910511640361 1.43446467417891e-06 -2.80762541350534 6.94439582460983e-20 MirTarget -0.742855109234426 3.46054975974042e-18 NA NA NA hsa-miR-199a-5p STIL -1.98848462405923 2.0421622713753e-11 2.27606240799083 3.73674028972289e-36 miRanda -0.157126355371172 5.55194145458849e-07 NA NA NA hsa-miR-195-5p STK35 -1.85907534356434 1.47434041676402e-22 0.639486866463096 6.71501847710025e-11 mirMAP -0.164021140309011 4.58921511370573e-12 NA NA NA hsa-miR-301a-3p STK40 0.842910511640361 1.43446467417891e-06 -0.821847220109252 4.78818932052572e-18 mirMAP -0.105880136128088 9.31404401876338e-05 NA NA NA hsa-miR-101-3p STMN1 -1.48176407980989 3.98950707385704e-31 1.91204257620119 3.19032860888253e-31 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.525610741856512 4.15373528715808e-18 NA NA NA hsa-miR-199a-5p STMN1 -1.98848462405923 2.0421622713753e-11 1.91204257620119 3.19032860888253e-31 miRanda -0.164645683908432 3.88362205054513e-09 NA NA NA hsa-miR-199a-5p STOX1 -1.98848462405923 2.0421622713753e-11 0.908191850274892 0.00444441908569481 miRanda -0.179322860545356 0.000451239933180605 NA NA NA hsa-miR-140-5p STRADA -0.220106443070144 0.0140713197101242 0.498302253980222 3.82764636239296e-12 miRanda -0.120688525055184 0.00273933234610203 NA NA NA hsa-miR-542-3p STRADA -1.31351015149842 3.64642423288576e-22 0.498302253980222 3.82764636239296e-12 miRanda -0.17474859665732 8.10925851097995e-13 NA NA NA hsa-miR-195-5p STX1A -1.85907534356434 1.47434041676402e-22 1.55573478321698 4.09371979939195e-26 MirTarget -0.235052694687642 3.05380728158982e-10 NA NA NA hsa-let-7c-5p STX3 -1.70744661345097 2.87934212005942e-20 0.268625915502391 0.0620467313021486 MirTarget -0.200597820665899 1.7582165585329e-08 NA NA NA hsa-miR-101-3p STX6 -1.48176407980989 3.98950707385704e-31 0.82528361429447 1.08822274383182e-21 MirTarget -0.335079167148673 6.21703992646483e-29 NA NA NA hsa-let-7c-5p SUB1 -1.70744661345097 2.87934212005942e-20 0.583706814960803 1.03979976716946e-11 MirTarget -0.151812387295251 1.54400818436745e-12 NA NA NA hsa-miR-101-3p SUB1 -1.48176407980989 3.98950707385704e-31 0.583706814960803 1.03979976716946e-11 miRNAWalker2_validate;MirTarget;miRNATAP -0.232432884310905 1.41890729730691e-14 27270442 Thus our study suggests that miR-101 loss results in increased SUB1 expression and subsequent activation of known oncogenes driving prostate cancer progression and metastasis metastasis;progression prostate cancer hsa-miR-301a-3p SYBU 0.842910511640361 1.43446467417891e-06 -1.03424280598767 8.76454515036323e-06 MirTarget;miRNATAP -0.561130720692538 1.45569705850483e-19 NA NA NA hsa-miR-101-3p SYNGAP1 -1.48176407980989 3.98950707385704e-31 0.236751509559486 0.0747028826209226 miRNATAP -0.171078363550902 0.000269323721594251 NA NA NA hsa-let-7c-5p TAZ -1.70744661345097 2.87934212005942e-20 0.956747824088997 5.51728917847337e-22 miRNAWalker2_validate -0.160843910434223 3.98057075434146e-10 NA NA NA hsa-let-7c-5p TBC1D13 -1.70744661345097 2.87934212005942e-20 0.861209565504011 9.70398365961959e-16 MirTarget -0.174153765242454 1.81958533488793e-10 NA NA NA hsa-miR-195-5p TBC1D13 -1.85907534356434 1.47434041676402e-22 0.861209565504011 9.70398365961959e-16 MirTarget -0.21859693061239 3.65462796994446e-17 NA NA NA hsa-miR-195-5p TBC1D16 -1.85907534356434 1.47434041676402e-22 1.09783247128337 3.62886274986965e-17 MirTarget -0.176249412526491 5.68671724164944e-08 NA NA NA hsa-miR-199a-5p TBC1D16 -1.98848462405923 2.0421622713753e-11 1.09783247128337 3.62886274986965e-17 mirMAP -0.108954301557034 3.74546556605929e-07 NA NA NA hsa-miR-199a-5p TBCE -1.98848462405923 2.0421622713753e-11 1.05798547934534 1.43180517582089e-23 miRanda -0.102773195936622 5.11249542593555e-09 NA NA NA hsa-let-7c-5p TBKBP1 -1.70744661345097 2.87934212005942e-20 0.916427652689533 7.35042591752853e-10 MirTarget -0.255902300442293 6.22257358099485e-12 NA NA NA hsa-miR-199a-5p TBX4 -1.98848462405923 2.0421622713753e-11 2.56980220706471 1.20540496718177e-08 miRanda -0.443126602270241 8.22982157744244e-10 NA NA NA hsa-miR-301a-3p TCF4 0.842910511640361 1.43446467417891e-06 -0.131793886763984 0.355169273660664 miRNATAP -0.144107058592396 0.000225478344923489 NA NA NA hsa-miR-199a-5p TCOF1 -1.98848462405923 2.0421622713753e-11 1.06738163786709 7.82640575865382e-26 miRanda -0.104046596170124 8.440618642944e-10 NA NA NA hsa-miR-199b-5p TCP10L -0.454049170125872 0.254611775331658 -1.70104654792918 1.17082058399226e-06 miRanda -0.149575037725325 0.000667709648868079 NA NA NA hsa-miR-301a-3p TEAD1 0.842910511640361 1.43446467417891e-06 -0.19170590497895 0.104550839525967 mirMAP -0.133308901900571 3.69667576952543e-05 NA NA NA hsa-miR-101-3p TEAD3 -1.48176407980989 3.98950707385704e-31 0.587514117440776 3.53184276495188e-10 miRNATAP -0.183497691208462 4.00252294081543e-08 NA NA NA hsa-miR-199a-5p TEF -1.98848462405923 2.0421622713753e-11 0.525410771213851 0.000338359038626339 PITA;miRanda -0.110872255873197 2.0810682367788e-06 NA NA NA hsa-miR-301a-3p TEF 0.842910511640361 1.43446467417891e-06 0.525410771213851 0.000338359038626339 mirMAP -0.128676940010715 0.0015109395944327 NA NA NA hsa-miR-301a-3p TESK2 0.842910511640361 1.43446467417891e-06 -1.01560084238235 8.87948423764961e-14 MirTarget -0.113437108436903 0.00335260468297898 NA NA NA hsa-miR-101-3p TFAP4 -1.48176407980989 3.98950707385704e-31 0.620275429911324 1.0228576574331e-09 miRNAWalker2_validate;miRNATAP -0.172440863730898 2.15881677858712e-06 NA NA NA hsa-miR-195-5p TFAP4 -1.85907534356434 1.47434041676402e-22 0.620275429911324 1.0228576574331e-09 miRNATAP -0.122410158528447 8.46211035953475e-07 NA NA NA hsa-miR-199b-5p TFPI -0.454049170125872 0.254611775331658 -0.692334589210751 0.00101475366143222 miRanda -0.108924434299291 3.12413476593142e-05 NA NA NA hsa-miR-301a-3p TGFBR2 0.842910511640361 1.43446467417891e-06 -0.522706741081292 3.47206054315007e-05 miRNATAP -0.183722985598573 1.11942744399345e-07 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-101-3p TGIF2 -1.48176407980989 3.98950707385704e-31 0.183370689181392 0.147188585278003 miRNAWalker2_validate;miRNATAP -0.288301825869561 5.10835944792471e-11 NA NA NA hsa-miR-195-5p TGIF2 -1.85907534356434 1.47434041676402e-22 0.183370689181392 0.147188585278003 MirTarget;miRNATAP -0.137685877309399 6.00126889664094e-06 NA NA NA hsa-miR-301a-3p THAP6 0.842910511640361 1.43446467417891e-06 -0.285775600723781 0.000112556152581908 mirMAP -0.129188278268462 1.08839682907831e-10 NA NA NA hsa-miR-199a-5p THNSL2 -1.98848462405923 2.0421622713753e-11 -0.407740023260917 0.123260952906428 miRanda -0.143136380038848 0.000699946833516806 NA NA NA hsa-miR-199b-5p THNSL2 -0.454049170125872 0.254611775331658 -0.407740023260917 0.123260952906428 miRanda -0.150299725709904 4.06783551992157e-06 NA NA NA hsa-miR-301a-3p THSD7A 0.842910511640361 1.43446467417891e-06 0.655648930436568 0.00549610436387998 miRNATAP -0.132199814196095 0.0433604915640731 NA NA NA hsa-miR-101-3p TIA1 -1.48176407980989 3.98950707385704e-31 0.479711437013162 4.13867615136867e-07 MirTarget;miRNATAP -0.15245148708297 6.2209246963713e-06 NA NA NA hsa-miR-195-5p TJAP1 -1.85907534356434 1.47434041676402e-22 0.700634549796933 6.17996946271343e-20 mirMAP -0.141970348176448 5.13838104919485e-14 NA NA NA hsa-miR-199a-5p TLCD1 -1.98848462405923 2.0421622713753e-11 1.46530704851583 5.20588945322843e-18 miRanda -0.144125432640393 2.51165870402692e-07 NA NA NA hsa-miR-195-5p TMC7 -1.85907534356434 1.47434041676402e-22 2.03760714579858 4.07529066351364e-21 MirTarget -0.214173604332978 9.65455987061493e-05 NA NA NA hsa-miR-195-5p TMCC1 -1.85907534356434 1.47434041676402e-22 -0.104762238614036 0.46647436251659 miRNATAP -0.133930634274483 0.000113195134256736 NA NA NA hsa-miR-199a-5p TMCO6 -1.98848462405923 2.0421622713753e-11 -9.22566609560249e-05 0.999456797214584 miRanda -0.120394975934278 1.59799243457597e-08 NA NA NA hsa-miR-199b-5p TMCO6 -0.454049170125872 0.254611775331658 -9.22566609560249e-05 0.999456797214584 miRanda -0.120283395187534 1.80417122799076e-13 NA NA NA hsa-miR-301a-3p TMED5 0.842910511640361 1.43446467417891e-06 -0.33764879066855 0.00113254692388959 miRNAWalker2_validate -0.106181439103802 0.000199296355425433 NA NA NA hsa-miR-195-5p TMEM104 -1.85907534356434 1.47434041676402e-22 0.843757768707635 5.73449815264737e-17 mirMAP -0.186063353291935 4.56008889086793e-14 NA NA NA hsa-miR-301a-3p TMEM110 0.842910511640361 1.43446467417891e-06 -0.263748642092995 0.0243287997140745 MirTarget;miRNATAP -0.169026688208051 1.14319516755262e-07 NA NA NA hsa-miR-195-5p TMEM120B -1.85907534356434 1.47434041676402e-22 1.34193310296135 3.11902100235044e-43 mirMAP -0.239415756033398 9.47893874671383e-22 NA NA NA hsa-miR-199b-5p TMEM150C -0.454049170125872 0.254611775331658 -0.91514940836625 0.00028364789222253 miRanda -0.144776384185334 3.68629589582039e-06 NA NA NA hsa-miR-301a-3p TMEM154 0.842910511640361 1.43446467417891e-06 -2.55127196617094 2.61178039289766e-16 mirMAP -0.224805922045145 0.0118177506247333 NA NA NA hsa-let-7c-5p TMEM165 -1.70744661345097 2.87934212005942e-20 0.581530725593331 1.55109884568793e-08 miRNAWalker2_validate -0.144842845795178 2.038268418118e-08 NA NA NA hsa-miR-101-3p TMEM168 -1.48176407980989 3.98950707385704e-31 0.364181474498545 0.000189921583843415 miRNAWalker2_validate -0.141694956755258 4.18282662990612e-05 NA NA NA hsa-miR-199a-3p TMEM170B -2.3279328685682 1.04468066198593e-17 -0.28665834823882 0.06540862544437 mirMAP -0.122249606258526 4.01456312098106e-06 NA NA NA hsa-let-7c-5p TMEM184B -1.70744661345097 2.87934212005942e-20 0.889593464258157 1.1912658512836e-19 miRNAWalker2_validate -0.170532146688534 1.19223629021959e-11 NA NA NA hsa-miR-195-5p TMEM198 -1.85907534356434 1.47434041676402e-22 1.11263779262795 9.21291761304099e-09 MirTarget -0.208607390340653 1.14099205765623e-05 NA NA NA hsa-miR-195-5p TMEM201 -1.85907534356434 1.47434041676402e-22 1.26425577239023 2.24180741272478e-27 mirMAP -0.211401398561954 7.05284812741662e-13 NA NA NA hsa-miR-199a-5p TMEM38B -1.98848462405923 2.0421622713753e-11 0.308790577122633 0.0156528587315526 miRanda -0.100213486771384 7.39308000794024e-07 NA NA NA hsa-miR-301a-3p TMEM56 0.842910511640361 1.43446467417891e-06 -1.75634225549522 4.44536598470124e-19 mirMAP -0.418769749264717 2.91428541829787e-14 NA NA NA hsa-miR-301a-3p TMEM64 0.842910511640361 1.43446467417891e-06 -0.00136604960589803 0.993609309009731 mirMAP -0.122283319261436 0.009182572783762 NA NA NA hsa-miR-101-3p TMEM65 -1.48176407980989 3.98950707385704e-31 0.63134880636871 1.29269140897777e-05 MirTarget -0.49926452452203 2.25074519678225e-24 NA NA NA hsa-miR-101-3p TMEM68 -1.48176407980989 3.98950707385704e-31 0.474216500765086 5.97643501944672e-07 MirTarget -0.147049957229934 1.38946618232325e-05 NA NA NA hsa-miR-199a-5p TMEM69 -1.98848462405923 2.0421622713753e-11 0.35034187533953 1.6258067224691e-05 miRanda -0.104514806077249 1.07398434380612e-16 NA NA NA hsa-miR-199a-5p TMEM97 -1.98848462405923 2.0421622713753e-11 0.12832687144911 0.435717895456315 miRanda -0.135399774520395 1.88345329686216e-07 NA NA NA hsa-miR-199b-5p TMEM97 -0.454049170125872 0.254611775331658 0.12832687144911 0.435717895456315 miRanda -0.110580685440175 4.09165660170936e-08 NA NA NA hsa-miR-101-3p TNRC18 -1.48176407980989 3.98950707385704e-31 0.610142294240987 5.19580615213061e-12 miRNATAP -0.151624410773924 1.90768043900602e-06 NA NA NA hsa-miR-301a-3p TNRC6A 0.842910511640361 1.43446467417891e-06 -0.27589759150465 0.00297509484248286 miRNATAP -0.14766032434 4.66877112841276e-09 NA NA NA hsa-miR-301a-3p TOM1L1 0.842910511640361 1.43446467417891e-06 -0.380676699923202 0.00715427307906511 MirTarget -0.149628617204517 0.000120463088748679 NA NA NA hsa-miR-199a-5p TOMM40L -1.98848462405923 2.0421622713753e-11 1.64819750802115 7.24144066555031e-42 miRanda -0.151308918773829 5.76643009888111e-13 NA NA NA hsa-miR-101-3p TRERF1 -1.48176407980989 3.98950707385704e-31 -0.366863939887298 0.0331874158506003 miRNAWalker2_validate;miRNATAP -0.173728623133496 0.00451996700360939 NA NA NA hsa-miR-301a-3p TRIM2 0.842910511640361 1.43446467417891e-06 -0.669569001903942 0.000204730952595103 miRNATAP -0.347377383873784 1.04277511177226e-12 NA NA NA hsa-miR-301a-3p TRIM23 0.842910511640361 1.43446467417891e-06 -0.298910242960821 0.000941811896082851 MirTarget -0.143705194330255 4.80872692384982e-09 NA NA NA hsa-miR-199b-5p TRIM55 -0.454049170125872 0.254611775331658 -0.84736038656361 0.124120581780373 miRanda -0.144450532640597 0.0353771390498446 NA NA NA hsa-miR-195-5p TRIM59 -1.85907534356434 1.47434041676402e-22 1.7356935499647 4.96522875209022e-19 MirTarget -0.231742142553597 2.27167796332891e-06 NA NA NA hsa-let-7c-5p TRIM67 -1.70744661345097 2.87934212005942e-20 0.526474972444801 0.0261906603203476 MirTarget -0.221979298256235 0.000181660256380273 NA NA NA hsa-miR-195-5p TRIM67 -1.85907534356434 1.47434041676402e-22 0.526474972444801 0.0261906603203476 mirMAP -0.164101235914266 0.00435446879592542 NA NA NA hsa-let-7c-5p TRIM71 -1.70744661345097 2.87934212005942e-20 1.88705329759216 3.31797883877253e-06 miRNAWalker2_validate;MirTarget -0.78785120052045 2.91205218598371e-15 NA NA NA hsa-miR-195-5p TRIP10 -1.85907534356434 1.47434041676402e-22 0.485959887830832 8.95150870263457e-05 miRNATAP -0.114014934656888 0.000157826072964174 NA NA NA hsa-miR-101-3p TRPC4 -1.48176407980989 3.98950707385704e-31 0.900010102499216 0.000266616389951708 MirTarget -0.403384435887304 4.03747842117632e-06 NA NA NA hsa-miR-10a-5p TSC1 -1.47723516092033 7.27299669108673e-16 0.920881916944059 1.33648384372723e-19 mirMAP -0.139629452664737 2.24435503048579e-07 NA NA NA hsa-miR-139-5p TSC1 -2.11299531796557 8.16407076415038e-28 0.920881916944059 1.33648384372723e-19 mirMAP -0.138969507847749 1.79604322012115e-08 NA NA NA hsa-miR-142-3p TSC1 -1.4243101967815 1.92609481097765e-14 0.920881916944059 1.33648384372723e-19 miRanda -0.126618039733337 2.13468537583732e-06 NA NA NA hsa-miR-195-3p TSC1 -1.09375690196245 4.70092324819807e-09 0.920881916944059 1.33648384372723e-19 mirMAP -0.102350213332177 0.000197504018678128 NA NA NA hsa-miR-23a-3p TSC1 -0.178875974460574 0.135978273540604 0.920881916944059 1.33648384372723e-19 mirMAP -0.10311318429677 0.0177752417141775 NA NA NA hsa-miR-335-5p TSC1 -1.61347836513558 1.62757083289711e-19 0.920881916944059 1.33648384372723e-19 miRNAWalker2_validate -0.127585694708462 3.44981987359883e-06 NA NA NA hsa-miR-3614-5p TSC1 -1.66311416965679 1.26647181860439e-15 0.920881916944059 1.33648384372723e-19 mirMAP -0.106465716187074 1.0480173495806e-05 NA NA NA hsa-miR-450b-5p TSC1 -1.34333360369432 2.68386079790462e-17 0.920881916944059 1.33648384372723e-19 mirMAP -0.130360378995634 2.9321967866797e-05 NA NA NA hsa-miR-542-3p TSC1 -1.31351015149842 3.64642423288576e-22 0.920881916944059 1.33648384372723e-19 PITA;miRanda -0.198207156237058 3.1659040994906e-08 NA NA NA hsa-miR-744-5p TSC2 -0.378868377317939 0.00125071229180016 0.454638169130336 1.34709422274577e-05 miRNAWalker2_validate -0.146650115106937 0.000784576818042153 NA NA NA hsa-miR-195-5p TSPYL2 -1.85907534356434 1.47434041676402e-22 0.293923107981491 0.0332588302573482 MirTarget;miRNATAP -0.103458534317622 0.00199828817143379 NA NA NA hsa-miR-199b-5p TST -0.454049170125872 0.254611775331658 -0.774941778981919 2.5527348136343e-06 miRanda;miRNATAP -0.121929378560043 2.10610921355847e-09 NA NA NA hsa-miR-199a-5p TTC9 -1.98848462405923 2.0421622713753e-11 1.33647962627701 1.22234162293908e-06 miRNATAP -0.131822074061736 0.00311960159580584 NA NA NA hsa-miR-199a-5p TTL -1.98848462405923 2.0421622713753e-11 0.841369670415339 1.94156847812526e-22 miRanda -0.106902628855522 3.44354522968078e-14 NA NA NA hsa-let-7c-5p TTLL4 -1.70744661345097 2.87934212005942e-20 1.09772685973996 1.47068858470308e-10 MirTarget -0.450426278450796 7.57793283588566e-28 NA NA NA hsa-miR-301a-3p TTPAL 0.842910511640361 1.43446467417891e-06 -1.04556741720129 5.1069901450973e-12 mirMAP -0.199974197867115 2.50432354276128e-06 NA NA NA hsa-miR-195-5p TTYH3 -1.85907534356434 1.47434041676402e-22 0.770555614902691 1.06180020960171e-06 mirMAP -0.134722667470947 0.000497337583894215 NA NA NA hsa-miR-199a-5p TUBG1 -1.98848462405923 2.0421622713753e-11 1.00556069919065 4.65567257361525e-21 miRanda;miRNATAP -0.130295468903879 7.48314494572641e-14 NA NA NA hsa-miR-101-3p TULP4 -1.48176407980989 3.98950707385704e-31 0.397850973202889 7.22845297744896e-06 MirTarget;miRNATAP -0.1151207219224 0.000267297199104939 NA NA NA hsa-miR-199a-5p TXNRD1 -1.98848462405923 2.0421622713753e-11 0.929311509729049 2.14760881993393e-07 miRanda;miRNATAP -0.149344540637832 2.02768915285535e-07 NA NA NA hsa-miR-195-5p TYSND1 -1.85907534356434 1.47434041676402e-22 0.507266973985128 1.57055994947472e-05 mirMAP -0.206734659892026 1.37870189973303e-13 NA NA NA hsa-let-7c-5p UBA52 -1.70744661345097 2.87934212005942e-20 0.28393248928586 0.0110134022626622 miRNAWalker2_validate -0.106594975606236 0.000134675405654401 NA NA NA hsa-miR-101-3p UBE2A -1.48176407980989 3.98950707385704e-31 0.634506070123654 7.31734785155335e-17 MirTarget;miRNATAP -0.18395554034392 1.68078876782851e-11 NA NA NA hsa-miR-101-3p UBE2D1 -1.48176407980989 3.98950707385704e-31 0.0779402641757883 0.369347660871645 MirTarget;miRNATAP -0.192269094165042 1.60239733657811e-10 NA NA NA hsa-miR-101-3p UBE2D2 -1.48176407980989 3.98950707385704e-31 0.245532981651438 3.42029764206399e-05 MirTarget;miRNATAP -0.10247018239037 8.46478116520751e-07 NA NA NA hsa-miR-101-3p UBE2Q1 -1.48176407980989 3.98950707385704e-31 0.732919157465649 1.09455000536515e-20 miRNATAP -0.152776907570506 1.15801434125006e-07 NA NA NA hsa-miR-195-5p UBE2Q1 -1.85907534356434 1.47434041676402e-22 0.732919157465649 1.09455000536515e-20 MirTarget;miRNATAP -0.129007554668754 3.94415128463069e-11 NA NA NA hsa-miR-199a-5p UBQLN4 -1.98848462405923 2.0421622713753e-11 0.909760847711772 1.9819003232081e-19 miRNATAP -0.114497537411039 3.51415457635709e-12 NA NA NA hsa-miR-199a-3p UCK2 -2.3279328685682 1.04468066198593e-17 1.18360816028226 8.55973566464538e-22 MirTarget;PITA;miRNATAP -0.178196380644244 1.24303852450857e-16 NA NA NA hsa-miR-101-3p UGGT1 -1.48176407980989 3.98950707385704e-31 0.553015890460785 2.70296855980024e-08 MirTarget -0.121905892999269 0.000644350528337366 NA NA NA hsa-miR-199b-5p UGT1A4 -0.454049170125872 0.254611775331658 -3.36385452578458 2.40497028381343e-09 miRanda -0.289002501662359 4.81886450770914e-05 NA NA NA hsa-miR-10b-3p ULK2 2.77189254628215 2.26687582932628e-20 -0.751057335334513 0.00080135979131828 MirTarget -0.148313505499471 7.61598951514493e-05 NA NA NA hsa-miR-130b-3p ULK2 0.687190305027546 0.000109068658562255 -0.751057335334513 0.00080135979131828 MirTarget -0.255363263740498 2.88541774955778e-05 NA NA NA hsa-miR-361-5p ULK2 0.233202959858696 0.00961572812255327 -0.751057335334513 0.00080135979131828 miRanda;miRNATAP -0.280930943836965 0.0228686012556111 NA NA NA hsa-miR-195-5p UNC119B -1.85907534356434 1.47434041676402e-22 1.21392832041535 7.88210718787103e-18 MirTarget -0.248523963974163 9.0844307221891e-13 NA NA NA hsa-miR-195-5p URM1 -1.85907534356434 1.47434041676402e-22 0.377286722665545 4.08493862379565e-05 mirMAP -0.10752785032162 1.30918331265113e-06 NA NA NA hsa-miR-195-5p USP14 -1.85907534356434 1.47434041676402e-22 0.448335849885336 1.34580227812328e-09 MirTarget -0.11257245490294 2.99607318956159e-10 NA NA NA hsa-miR-195-5p USP22 -1.85907534356434 1.47434041676402e-22 0.620225817612547 2.78559526456339e-10 mirMAP -0.15300615291279 1.38158647758755e-10 NA NA NA hsa-miR-301a-3p USP47 0.842910511640361 1.43446467417891e-06 -0.288927257048455 1.31798435018082e-05 miRNATAP -0.105148498563912 5.50298367671624e-09 NA NA NA hsa-miR-195-5p VAT1 -1.85907534356434 1.47434041676402e-22 0.562790262628507 4.63985079216808e-06 MirTarget;miRNATAP -0.17069539010941 8.58003344061417e-09 NA NA NA hsa-miR-101-3p VCAN -1.48176407980989 3.98950707385704e-31 0.3467634039065 0.320202578720279 miRNATAP -0.683578145591999 2.13971948153848e-08 NA NA NA hsa-miR-150-5p VEGFA -1.14624309254329 1.51365525978726e-06 0.0263183839451075 0.81382635000524 miRNAWalker2_validate;miRTarBase -0.114666527453602 2.4663414134099e-07 NA NA NA hsa-miR-29b-2-5p VEGFA -0.223258653034772 0.084306146519938 0.0263183839451075 0.81382635000524 MirTarget -0.132006150652748 0.00171675395806506 NA NA NA hsa-miR-29b-3p VEGFA -0.348885528720517 0.0121441341291285 0.0263183839451075 0.81382635000524 miRNAWalker2_validate;miRTarBase;MirTarget -0.125790856471025 0.00126089778683366 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-140-5p VEGFB -0.220106443070144 0.0140713197101242 0.0320278813662975 0.892480348417874 miRanda -0.268562632744809 0.0395419509098586 NA NA NA hsa-miR-128-3p VEGFC 0.289735108018712 0.0114419474207889 0.0031169028254141 0.982787493023474 miRNAWalker2_validate;MirTarget -0.198618366596319 0.00124097531466772 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-16-2-3p VEGFC -0.0336420826463706 0.805158952566973 0.0031169028254141 0.982787493023474 MirTarget -0.149514000508957 0.00387572506927192 NA NA NA hsa-miR-374a-5p VEGFC 0.016390363747302 0.869784217438621 0.0031169028254141 0.982787493023474 MirTarget -0.28522635078723 5.53265846690998e-05 NA NA NA hsa-miR-374b-5p VEGFC -0.307538028546424 0.0030079617545972 0.0031169028254141 0.982787493023474 MirTarget -0.209454919974677 0.00209421071373184 NA NA NA hsa-miR-590-3p VEGFC -0.473167498047808 1.76652934637227e-05 0.0031169028254141 0.982787493023474 miRanda -0.274821384359749 1.36978001441178e-05 NA NA NA hsa-miR-101-3p VLDLR -1.48176407980989 3.98950707385704e-31 -0.0354447533347528 0.927085642100091 miRNATAP -0.379191038914431 0.00577853127128566 NA NA NA hsa-miR-301a-3p VPS13D 0.842910511640361 1.43446467417891e-06 -0.361613248828933 4.73065781347578e-05 MirTarget -0.165847866111678 5.1395321993533e-12 NA NA NA hsa-miR-195-5p VPS37C -1.85907534356434 1.47434041676402e-22 0.523558943404517 1.59955591546831e-13 miRNATAP -0.102840984463797 3.16949515358372e-09 NA NA NA hsa-miR-301a-3p WDFY3 0.842910511640361 1.43446467417891e-06 -0.56665445395217 1.30950023006267e-05 MirTarget;miRNATAP -0.109968183802448 0.00231883069812908 NA NA NA hsa-miR-199a-5p WDR76 -1.98848462405923 2.0421622713753e-11 2.20023167890106 2.74971882187716e-27 MirTarget;miRNATAP -0.200301432218432 4.84574601997636e-09 NA NA NA hsa-miR-199b-5p WNK3 -0.454049170125872 0.254611775331658 -0.836532944570787 0.00785592148273515 PITA;miRanda;miRNATAP -0.108211991544482 0.00581219941684639 NA NA NA hsa-miR-301a-3p WNK3 0.842910511640361 1.43446467417891e-06 -0.836532944570787 0.00785592148273515 miRNATAP -0.47593726668891 2.92824729060657e-08 NA NA NA hsa-miR-195-5p WNT3A -1.85907534356434 1.47434041676402e-22 1.98708616870099 1.63071643507271e-06 MirTarget;miRNATAP -0.344445023915739 0.000703711150128669 25174704;26573286 MicroRNA 195 acts as a tumor suppressor by directly targeting Wnt3a in HepG2 hepatocellular carcinoma cells; Luciferase reporter assay was used to determine whether Wnt3a was a target of miR-195; Furthermore Wnt3a was demonstrated to be directly targeted by miR-195; These findings suggest that miR-195 is key in regulating cell proliferation cell cycle and apoptosis through targeting Wnt3a;Eribulin upregulates miR 195 expression and downregulates Wnt3a expression in non basal like type of triple negative breast cancer cell MDA MB 231; The expression level of miR-195 targeting Wnt3a significantly decreased compared to the control in MDA-MB-231 whereas it significantly increased in HCC1143; These results showed that exposure to eribulin highly increased the expression of miR-195 while it decreased the expression of Wnt3a in non-basal-like type of TNBC ; liver cancer;breast cancer hsa-miR-101-3p WWC3 -1.48176407980989 3.98950707385704e-31 0.418904533622248 0.000277343107042062 MirTarget -0.137133289226116 0.000823809403758886 NA NA NA hsa-miR-101-3p XPO5 -1.48176407980989 3.98950707385704e-31 0.924250934584309 5.58683264436527e-22 MirTarget -0.276746849134966 1.32419502057425e-15 NA NA NA hsa-miR-101-3p XPR1 -1.48176407980989 3.98950707385704e-31 0.544137944622799 1.91103515215534e-07 miRNATAP -0.17574828256305 2.33554219572299e-06 NA NA NA hsa-miR-101-3p XYLT1 -1.48176407980989 3.98950707385704e-31 -0.33071246838403 0.0992663538586554 miRNATAP -0.220711670025347 0.00191969792737554 NA NA NA hsa-miR-301a-3p YIPF6 0.842910511640361 1.43446467417891e-06 -0.130504002208799 0.166772554218636 mirMAP -0.142805965776466 2.29691654295661e-08 NA NA NA hsa-miR-301a-3p YPEL1 0.842910511640361 1.43446467417891e-06 -0.0280512828396375 0.84677585658497 mirMAP -0.14390460432855 0.000297842803838576 NA NA NA hsa-miR-101-3p ZBED4 -1.48176407980989 3.98950707385704e-31 0.53235542847144 2.61984249684361e-08 MirTarget;miRNATAP -0.187138973431622 3.60444684650439e-08 NA NA NA hsa-miR-195-5p ZBTB33 -1.85907534356434 1.47434041676402e-22 0.176119332344838 0.119623028344143 MirTarget -0.101011165290478 0.000216775847686314 NA NA NA hsa-miR-101-3p ZBTB34 -1.48176407980989 3.98950707385704e-31 0.377013703257521 0.000168925671855812 MirTarget;miRNATAP -0.186084378643133 1.3560686824694e-07 NA NA NA hsa-miR-195-5p ZBTB40 -1.85907534356434 1.47434041676402e-22 1.05248854418575 1.34458961008934e-27 mirMAP -0.177498588894441 3.30847215525159e-13 NA NA NA hsa-miR-195-5p ZBTB9 -1.85907534356434 1.47434041676402e-22 0.87712713759988 1.92214381535763e-22 MirTarget;miRNATAP -0.207072937800983 3.29354816454658e-21 NA NA NA hsa-let-7c-5p ZC3H3 -1.70744661345097 2.87934212005942e-20 1.0612730707833 1.57569638197004e-20 MirTarget -0.199043730435108 1.27659419619969e-11 NA NA NA hsa-miR-301a-3p ZCCHC14 0.842910511640361 1.43446467417891e-06 -0.499988131084804 9.91660995682074e-07 MirTarget;miRNATAP -0.123782640124249 1.17855788865284e-05 NA NA NA hsa-miR-301a-3p ZDHHC15 0.842910511640361 1.43446467417891e-06 -1.05212931450714 4.19710859293851e-05 mirMAP -0.148210763988684 0.0383375067433643 NA NA NA hsa-miR-301a-3p ZEB2 0.842910511640361 1.43446467417891e-06 -1.50896689448163 2.21480558222559e-19 miRNATAP -0.139526450494557 0.00389842048921833 NA NA NA hsa-miR-195-5p ZFP41 -1.85907534356434 1.47434041676402e-22 1.68571425193753 7.24184178265088e-33 mirMAP -0.244445130299728 1.68600961893763e-11 NA NA NA hsa-miR-301a-3p ZFPM2 0.842910511640361 1.43446467417891e-06 -2.22408950189141 1.94401967403455e-22 miRNATAP -0.346024853174742 1.34295768907978e-07 NA NA NA hsa-miR-301a-3p ZFYVE9 0.842910511640361 1.43446467417891e-06 -0.342162134568488 0.000131097224279702 MirTarget;miRNATAP -0.115492725903964 2.49829587299703e-06 NA NA NA hsa-miR-101-3p ZIK1 -1.48176407980989 3.98950707385704e-31 -0.14574848376165 0.539972302988549 MirTarget -0.16838094292829 0.0463557948307044 NA NA NA hsa-miR-301a-3p ZMAT3 0.842910511640361 1.43446467417891e-06 -0.69014006285696 7.01619041120993e-05 MirTarget -0.293992950935408 5.22581016691463e-10 NA NA NA hsa-miR-101-3p ZNF207 -1.48176407980989 3.98950707385704e-31 0.476017454845254 1.69423309001909e-17 miRNATAP -0.164875338857795 6.57208298902814e-17 NA NA NA hsa-miR-301a-3p ZNF275 0.842910511640361 1.43446467417891e-06 -0.574727473167436 1.56652833569366e-06 mirMAP;miRNATAP -0.132573791489614 6.40537277927699e-05 NA NA NA hsa-miR-101-3p ZNF469 -1.48176407980989 3.98950707385704e-31 -0.525222123924474 0.015528259270098 miRNATAP -0.349244085173973 5.14736316798517e-06 NA NA NA hsa-miR-199a-5p ZNF503 -1.98848462405923 2.0421622713753e-11 0.22587365787045 0.232944065367825 PITA;miRanda;miRNATAP -0.133838666504691 8.39442325676151e-06 NA NA NA hsa-miR-199b-5p ZNF503 -0.454049170125872 0.254611775331658 0.22587365787045 0.232944065367825 PITA;miRanda;miRNATAP -0.123103036209095 1.15830267732324e-07 NA NA NA hsa-miR-450a-5p ZNF503-AS2 -1.65464197503467 7.32200902934081e-23 1.20127345257722 8.24651611109528e-15 mirMAP -0.149232279711751 4.46842536304462e-06 NA NA NA hsa-let-7c-5p ZNF512B -1.70744661345097 2.87934212005942e-20 0.949756749303405 1.79541489585724e-18 MirTarget -0.178134616117144 1.43198078159576e-10 NA NA NA hsa-miR-195-5p ZNF512B -1.85907534356434 1.47434041676402e-22 0.949756749303405 1.79541489585724e-18 mirMAP -0.235249343978175 3.26225649946131e-19 NA NA NA hsa-miR-199a-5p ZNF512B -1.98848462405923 2.0421622713753e-11 0.949756749303405 1.79541489585724e-18 MirTarget;miRNATAP -0.105627117656042 2.74634155937844e-09 NA NA NA hsa-let-7c-5p ZNF526 -1.70744661345097 2.87934212005942e-20 0.694364272257119 1.11242011006087e-21 miRNAWalker2_validate -0.147571959257241 1.3126555892882e-15 NA NA NA hsa-miR-101-3p ZNF532 -1.48176407980989 3.98950707385704e-31 0.726511739143307 7.11049790812266e-06 MirTarget;miRNATAP -0.459700440373581 2.22875609923918e-16 NA NA NA hsa-miR-199a-5p ZNF544 -1.98848462405923 2.0421622713753e-11 0.826167744193755 2.45371066864106e-10 miRanda;miRNATAP -0.10530769272577 6.01563057703766e-07 NA NA NA hsa-miR-199a-5p ZNF572 -1.98848462405923 2.0421622713753e-11 1.32697063620741 6.58899950061161e-15 miRanda -0.186172825537172 1.40407327364798e-11 NA NA NA hsa-miR-199b-5p ZNF572 -0.454049170125872 0.254611775331658 1.32697063620741 6.58899950061161e-15 miRanda -0.107400144903812 7.22240074263107e-07 NA NA NA hsa-let-7c-5p ZNF581 -1.70744661345097 2.87934212005942e-20 1.08114010713937 1.93294426178797e-17 miRNAWalker2_validate -0.315580993313553 1.10992003321011e-23 NA NA NA hsa-miR-101-3p ZNF618 -1.48176407980989 3.98950707385704e-31 0.943831859691578 2.40047580237559e-12 miRNATAP -0.341664932943391 9.21365992863627e-13 NA NA NA hsa-miR-301a-3p ZNF684 0.842910511640361 1.43446467417891e-06 -0.818500366806858 9.17529650228481e-08 MirTarget;miRNATAP -0.209818837980564 7.59389677483937e-07 NA NA NA hsa-miR-195-5p ZNF696 -1.85907534356434 1.47434041676402e-22 1.1659366469838 7.3613166564401e-23 mirMAP -0.219336187400075 1.03218048568432e-13 NA NA NA hsa-miR-101-3p ZNF701 -1.48176407980989 3.98950707385704e-31 0.0789677403634204 0.717148346237302 mirMAP -0.194890683037937 0.0117379376494971 NA NA NA hsa-let-7c-5p ZNF710 -1.70744661345097 2.87934212005942e-20 0.313248196006383 0.103373907581206 MirTarget -0.120535446215635 0.0125911174137927 NA NA NA hsa-miR-101-3p ZNF746 -1.48176407980989 3.98950707385704e-31 0.504549701393687 1.81855502334155e-07 MirTarget -0.120978284019877 0.000478826657748534 NA NA NA hsa-miR-101-3p ZNF792 -1.48176407980989 3.98950707385704e-31 0.88178827950768 7.59290448450019e-16 miRNAWalker2_validate -0.296329354279492 3.17017652988387e-14 NA NA NA hsa-miR-301a-3p ZNF800 0.842910511640361 1.43446467417891e-06 -0.688320107756163 4.23497321998893e-12 MirTarget;miRNATAP -0.127869678770354 4.30956650637534e-06 NA NA NA hsa-miR-199a-5p ZSWIM5 -1.98848462405923 2.0421622713753e-11 1.1829090996225 0.000142288273228735 miRanda -0.305154258366177 5.58600340913268e-10 NA NA NA hsa-miR-199b-5p ZSWIM5 -0.454049170125872 0.254611775331658 1.1829090996225 0.000142288273228735 miRanda -0.104102074974501 0.00752014511327026 NA NA NA