miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-30e-5p ABL1 1.60414100786743 3.78951090573667e-19 -0.0963586766222937 0.42908310012577 MirTarget;miRNATAP -0.113209719586126 0.000160465315502252 NA NA NA hsa-miR-140-3p ANAPC1 -1.11373309124537 8.35257079443689e-14 0.431254945270199 0.00237767171781094 MirTarget -0.189892186180698 9.44520730260268e-06 NA NA NA hsa-miR-26b-5p ANAPC1 0.72362441215247 4.7794659748036e-05 0.431254945270199 0.00237767171781094 miRNAWalker2_validate -0.143361268176673 9.03642825192532e-05 NA NA NA hsa-miR-30c-2-3p ANAPC7 -3.10905250533941 6.84550165664783e-27 0.385216157523693 0.000358178340027037 MirTarget -0.129129088542216 1.91006682073905e-16 NA NA NA hsa-miR-664a-5p ATR -0.0936480603578111 0.662274905077117 0.550683780115255 1.77066789898484e-06 mirMAP -0.100350035287241 9.0707123785835e-05 NA NA NA hsa-miR-139-5p BUB1 -2.26625553116965 7.22375119369519e-16 2.44836139769095 5.99235914565858e-15 miRanda -0.437183314762451 1.01162524149959e-18 NA NA NA hsa-miR-199a-5p BUB1 1.3057193856884 2.38429382751645e-08 2.44836139769095 5.99235914565858e-15 miRanda -0.183096876367639 0.00359505184481577 NA NA NA hsa-miR-199b-5p BUB1 2.13822205171062 4.56262988762436e-15 2.44836139769095 5.99235914565858e-15 miRanda -0.147388312038259 0.00542898085632305 NA NA NA hsa-miR-486-5p BUB1B -4.38592782786845 2.75864166493846e-29 3.44071235405621 1.22510866063497e-25 miRanda -0.284328499679257 2.94130571622496e-14 NA NA NA hsa-miR-139-5p BUB3 -2.26625553116965 7.22375119369519e-16 0.629160190707819 8.52212835608142e-09 miRanda -0.137178481692308 7.73959308449106e-16 NA NA NA hsa-miR-107 CCNA1 0.658676029898313 5.11480446318819e-07 -1.86345219397217 0.000936096173079234 miRanda -0.632855840214844 0.00150644736421389 NA NA NA hsa-miR-30d-5p CCNA1 -0.920901858717441 3.50898334321668e-05 -1.86345219397217 0.000936096173079234 MirTarget -0.302736838723365 0.00946001443459966 NA NA NA hsa-let-7a-3p CCNA2 0.167285443861993 0.431834813181487 2.68958557277422 1.76349887174632e-19 MirTarget -0.232834253775044 0.00207347391725921 NA NA NA hsa-let-7b-3p CCNA2 -1.81889978084306 6.9913416210266e-19 2.68958557277422 1.76349887174632e-19 MirTarget -0.525911470526005 8.39825192401236e-16 NA NA NA hsa-let-7b-5p CCNA2 -1.62016148171663 1.56547487335694e-15 2.68958557277422 1.76349887174632e-19 miRNAWalker2_validate;miRTarBase -0.586488083704599 5.83538722149095e-19 NA NA NA hsa-miR-200b-3p CCNA2 1.55157578247391 4.83790020897188e-09 2.68958557277422 1.76349887174632e-19 TargetScan -0.198080558533404 0.000183135210226401 NA NA NA hsa-miR-218-5p CCNA2 -0.281408491748349 0.259553612322657 2.68958557277422 1.76349887174632e-19 MirTarget -0.386209293272515 2.40503610168003e-11 NA NA NA hsa-miR-27b-3p CCNA2 0.236438984240408 0.12263510345883 2.68958557277422 1.76349887174632e-19 miRNATAP -0.355086127687899 0.000162463956907817 NA NA NA hsa-miR-29a-3p CCNA2 0.101650412194573 0.573201097011668 2.68958557277422 1.76349887174632e-19 MirTarget -0.455931856017668 7.38229306418232e-09 NA NA NA hsa-miR-29c-3p CCNA2 1.32354490728858 1.84279305179762e-07 2.68958557277422 1.76349887174632e-19 MirTarget -0.29943521648153 5.41989724705699e-08 NA NA NA hsa-miR-320a CCNA2 -0.961144925954715 1.62478794429204e-08 2.68958557277422 1.76349887174632e-19 miRanda -0.331002127855598 6.77663104169446e-05 NA NA NA hsa-miR-34c-5p CCNA2 -1.00125440032112 0.0724432896090357 2.68958557277422 1.76349887174632e-19 miRanda -0.141371739407449 1.16815427223355e-07 NA NA NA hsa-miR-455-5p CCNA2 1.36946341828134 5.05118627562807e-08 2.68958557277422 1.76349887174632e-19 miRanda -0.253175598764062 9.21932479310347e-05 NA NA NA hsa-miR-486-5p CCNA2 -4.38592782786845 2.75864166493846e-29 2.68958557277422 1.76349887174632e-19 miRanda -0.220319563683076 6.0749520776795e-11 NA NA NA hsa-miR-508-3p CCNA2 0.140176864166629 0.79184421367121 2.68958557277422 1.76349887174632e-19 MirTarget;PITA;miRNATAP -0.142048144121562 2.12285014855551e-07 NA NA NA hsa-let-7b-5p CCNB1 -1.62016148171663 1.56547487335694e-15 2.58605326822805 1.49721003431101e-20 miRNAWalker2_validate -0.600740382615842 9.27053199216893e-23 NA NA NA hsa-miR-139-5p CCNB1 -2.26625553116965 7.22375119369519e-16 2.58605326822805 1.49721003431101e-20 miRanda -0.399807636878469 2.18106497381391e-19 NA NA NA hsa-let-7a-5p CCNB2 -1.37014061604018 3.11451492971224e-14 3.04708109169996 5.83056043976083e-23 miRNAWalker2_validate -0.568312373812622 7.0365010069257e-13 NA NA NA hsa-let-7b-5p CCNB2 -1.62016148171663 1.56547487335694e-15 3.04708109169996 5.83056043976083e-23 miRNAWalker2_validate -0.613229739107824 5.61658809656701e-19 NA NA NA hsa-let-7c-5p CCNB2 -2.14139413005852 1.66416999341685e-18 3.04708109169996 5.83056043976083e-23 miRNAWalker2_validate -0.617345582596585 1.15760664423345e-28 NA NA NA hsa-miR-23b-3p CCNB2 -0.070273068040148 0.620585267977425 3.04708109169996 5.83056043976083e-23 miRNAWalker2_validate -0.601133570738828 1.22608993636691e-08 NA NA NA hsa-miR-106a-5p CCND1 1.3902608059488 6.07931522284525e-05 -0.295767629587253 0.255400743295204 MirTarget;miRNATAP -0.247441760563832 4.58943715400631e-11 NA NA NA hsa-miR-106b-5p CCND1 1.47447672652218 1.32004094930462e-13 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.261384817974007 7.4979419817232e-06 NA NA NA hsa-miR-142-3p CCND1 3.98476449801341 1.56256182021111e-35 -0.295767629587253 0.255400743295204 miRanda -0.119299030581201 0.000532277158339159 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colon cancer hsa-miR-15a-5p CCND1 1.62575353599172 1.55312121019827e-19 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.199069637483131 0.0019294787514794 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-15b-5p CCND1 -1.25935038177398 1.83460220856901e-12 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.303824360423629 3.25741318048184e-06 NA NA NA hsa-miR-16-1-3p CCND1 1.50034693398929 6.63958242991125e-10 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase -0.249107447749185 3.23141967346606e-05 22922827;18483394 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ; sarcoma;lymphoma hsa-miR-16-5p CCND1 0.749619098384047 4.11649450706988e-06 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.371885624299403 3.21606546730418e-07 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-17-5p CCND1 2.07078488653279 2.77403038572568e-19 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.313758634258834 1.59321495552009e-10 26431674 Bioinformatics Prediction and In Vitro Analysis Revealed That miR 17 Targets Cyclin D1 mRNA in Triple Negative Breast Cancer Cells; In this study using bioinformatic analyses miR-17 was selected as it targets the 3'UTR of CCND1 gene with the highest score; After lentiviral transduction of miR-17 to the target cells gene expression analysis showed decreased expression of CCND1 gene breast cancer hsa-miR-186-5p CCND1 0.852175445703945 6.88885738584309e-10 -0.295767629587253 0.255400743295204 mirMAP -0.377477028673122 1.06268066352005e-05 NA NA NA hsa-miR-193a-3p CCND1 0.549173467360291 0.0319030569365466 -0.295767629587253 0.255400743295204 MirTarget;PITA;miRanda -0.190950932146342 0.000161171890671323 NA NA NA hsa-miR-193b-3p CCND1 1.10444771306846 0.000822888533401377 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget -0.147999411883792 3.70620495015026e-05 27071318;20655737;20304954;21893020;26129688 MicroRNA 193b inhibits the proliferation migration and invasion of gastric cancer cells via targeting cyclin D1; Further mechanism study indicated that CCND1 was a direct target of miR-193b in GC;CCND1 and ETS1 were revealed to be regulated by miR-193b directly;MicroRNA 193b represses cell proliferation and regulates cyclin D1 in melanoma; Overexpression of miR-193b in Malme-3M cells down-regulated CCND1 mRNA and protein by > or = 50%; A luciferase reporter assay confirmed that miR-193b directly regulates CCND1 by binding to the 3'untranslated region of CCND1 mRNA; These studies indicate that miR-193b represses cell proliferation and regulates CCND1 expression and suggest that dysregulation of miR-193b may play an important role in melanoma development;In a previous study we reported that miR-193b represses cell proliferation and regulates cyclin D1 in melanoma cells suggesting that miR-193b could act as a tumor suppressor;Epigenetically altered miR 193b targets cyclin D1 in prostate cancer; It has been suggested that miR-193b targets cyclin D1 in several malignancies; Here our aim was to determine if miR-193b targets cyclin D1 in prostate cancer; Furthermore the PC cell lines 22Rv1 and VCaP which express low levels of miR-193b and high levels of CCND1 showed significant growth retardation when treated with a CDK4/6 inhibitor; In contrast the inhibitor had no effect on the growth of PC-3 and DU145 cells with high miR-193b and low CCND1 expression; Taken together our data demonstrate that miR-193b targets cyclin D1 in prostate cancer ;;;; gastric cancer;liver cancer;melanoma;melanoma;prostate cancer hsa-miR-19a-3p CCND1 2.11776595911517 7.07663078397156e-10 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;miRNATAP -0.21539529985992 9.86203433305448e-08 25985117 Moreover miR-19a might play inhibitory roles in HCC malignancy via regulating Cyclin D1 expression liver cancer hsa-miR-19b-1-5p CCND1 1.71217036351784 3.28561659177495e-12 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase -0.301713494105536 2.89182846291565e-08 NA NA NA hsa-miR-19b-3p CCND1 2.10868505662119 5.40846613768389e-17 -0.295767629587253 0.255400743295204 miRNATAP -0.179773518063806 0.000197856717032667 NA NA NA hsa-miR-20a-5p CCND1 2.64649625616975 5.1469418982085e-27 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.237160136465301 1.84669386058676e-07 NA NA NA hsa-miR-20b-5p CCND1 1.35770573270947 0.00260808530013016 -0.295767629587253 0.255400743295204 MirTarget;miRNATAP -0.179107595068828 5.65966117118738e-11 NA NA NA hsa-miR-365a-3p CCND1 0.0132777124336201 0.953597412537431 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;miRTarBase -0.193166924738263 0.000234492957903034 NA NA NA hsa-miR-374a-5p CCND1 -0.197027254874826 0.298080902192861 -0.295767629587253 0.255400743295204 MirTarget -0.313785702713176 9.54081268797886e-06 27191497 microRNA 374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway; Furthermore luciferase reporter assays confirmed that miR-374a could directly reduce CCND1; We examined miR-374a levels by in situ hybridization and its correlation with CCND1 expression in CRC tumor tissues; High miR-374a expression with low level of CCND1 was protective factor in CRC; Together these findings indicate that miR-374a inactivates the PI3K/AKT axis by inhibiting CCND1 suppressing of colon cancer progression progression colon cancer hsa-miR-374b-5p CCND1 0.474691035780475 0.0109217471394203 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;MirTarget -0.26116225100222 0.00011561978488339 NA NA NA hsa-miR-425-5p CCND1 1.21659524959201 8.01126418494715e-09 -0.295767629587253 0.255400743295204 miRNAWalker2_validate -0.245575402525843 1.03844251357893e-05 NA NA NA hsa-miR-589-3p CCND1 1.34253876396688 1.84935927493927e-05 -0.295767629587253 0.255400743295204 MirTarget -0.130907472589194 0.000793150025378685 NA NA NA hsa-miR-590-3p CCND1 0.83851360565783 0.00129224433453587 -0.295767629587253 0.255400743295204 mirMAP -0.182941292569374 0.000856336828554768 NA NA NA hsa-miR-769-3p CCND1 0.452126659761753 0.0748150639143322 -0.295767629587253 0.255400743295204 mirMAP -0.142316943866129 0.00276805281261241 NA NA NA hsa-miR-92a-3p CCND1 -0.136362762339122 0.493412263619364 -0.295767629587253 0.255400743295204 miRNAWalker2_validate -0.337251172229938 1.62058605849004e-08 NA NA NA hsa-miR-93-5p CCND1 1.50844106515467 1.83836866996875e-12 -0.295767629587253 0.255400743295204 miRNAWalker2_validate;MirTarget;miRNATAP -0.320397820083252 2.84014735439528e-09 NA NA NA hsa-miR-942-5p CCND1 -0.0372813055050076 0.870631058767894 -0.295767629587253 0.255400743295204 MirTarget -0.177314558661089 0.000979800060419363 NA NA NA hsa-miR-106a-5p CCND2 1.3902608059488 6.07931522284525e-05 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.149132151233025 1.88464236882735e-05 NA NA NA hsa-miR-106b-5p CCND2 1.47447672652218 1.32004094930462e-13 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.383655587509124 2.65429916887189e-13 NA NA NA hsa-miR-130b-5p CCND2 1.53645187062942 1.10498816261505e-08 -1.64140990579885 1.49666938681079e-12 mirMAP -0.268032769997331 9.22343432530747e-12 NA NA NA hsa-miR-141-3p CCND2 3.36993755486106 5.42939251147195e-32 -1.64140990579885 1.49666938681079e-12 MirTarget;TargetScan -0.239914655059016 6.4654039095017e-12 NA NA NA hsa-miR-151a-3p CCND2 0.665271883054405 0.000281673348137154 -1.64140990579885 1.49666938681079e-12 mirMAP -0.279142680983949 2.60564778780149e-06 NA NA NA hsa-miR-15a-5p CCND2 1.62575353599172 1.55312121019827e-19 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.158338209854594 0.00711668272045409 NA NA NA hsa-miR-17-5p CCND2 2.07078488653279 2.77403038572568e-19 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.365048259055278 1.61934056872758e-16 NA NA NA hsa-miR-182-5p CCND2 3.21839823004635 5.13049145201115e-39 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.373145719566719 1.32597677460149e-21 NA NA NA hsa-miR-183-5p CCND2 2.39247234736657 3.92444525331999e-21 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.410520271082553 1.11291256348519e-25 NA NA NA hsa-miR-185-5p CCND2 1.14291034858482 2.95777119743491e-13 -1.64140990579885 1.49666938681079e-12 MirTarget;miRNATAP -0.23940712387784 0.000484175543966546 NA NA NA hsa-miR-186-5p CCND2 0.852175445703945 6.88885738584309e-10 -1.64140990579885 1.49666938681079e-12 mirMAP;miRNATAP -0.357370184588874 5.14493635358813e-06 NA NA NA hsa-miR-191-5p CCND2 0.343645878547116 0.0668114086143391 -1.64140990579885 1.49666938681079e-12 MirTarget -0.19767765908675 0.000750401585158583 NA NA NA hsa-miR-19a-3p CCND2 2.11776595911517 7.07663078397156e-10 -1.64140990579885 1.49666938681079e-12 MirTarget;miRNATAP -0.167455065978335 6.56621464464812e-06 NA NA NA hsa-miR-19b-3p CCND2 2.10868505662119 5.40846613768389e-17 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.19157786848984 1.39328108679414e-05 NA NA NA hsa-miR-200a-3p CCND2 3.14766878548496 1.32850889777422e-21 -1.64140990579885 1.49666938681079e-12 MirTarget -0.173744823500602 6.53232158053391e-08 NA NA NA hsa-miR-20a-5p CCND2 2.64649625616975 5.1469418982085e-27 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate;miRTarBase;miRNATAP -0.28367508352758 5.6750334332974e-12 NA NA NA hsa-miR-21-3p CCND2 2.54206008030157 1.11598785398763e-30 -1.64140990579885 1.49666938681079e-12 mirMAP -0.212907340098529 4.00646631535515e-06 NA NA NA hsa-miR-2355-3p CCND2 1.10676344164715 6.24068383465151e-06 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.221166273655799 1.96123873319489e-06 NA NA NA hsa-miR-28-5p CCND2 1.19639196514745 4.59365801666536e-18 -1.64140990579885 1.49666938681079e-12 miRanda -0.289410618824274 0.00017592467355866 NA NA NA hsa-miR-301a-3p CCND2 2.70198002906399 1.56420889710984e-14 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate -0.265639128307335 3.9945374923581e-13 NA NA NA hsa-miR-320b CCND2 0.226640952564488 0.378818692487242 -1.64140990579885 1.49666938681079e-12 mirMAP;miRNATAP -0.123605256651271 0.00373003525561283 NA NA NA hsa-miR-324-3p CCND2 -0.0774700133118458 0.689226297032231 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate -0.276159423764137 9.9462768745637e-07 NA NA NA hsa-miR-331-5p CCND2 0.578237334664505 0.00131211239210882 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.275952758002927 9.36107182529594e-06 NA NA NA hsa-miR-429 CCND2 2.3794516574089 1.72813419703734e-13 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.209322906628109 2.95963655497587e-09 NA NA NA hsa-miR-450b-5p CCND2 1.69248953402469 1.96052058003353e-07 -1.64140990579885 1.49666938681079e-12 MirTarget;PITA;miRNATAP -0.145422700655101 8.53356735526403e-05 NA NA NA hsa-miR-501-5p CCND2 0.411357595674671 0.10435288464149 -1.64140990579885 1.49666938681079e-12 PITA;mirMAP;miRNATAP -0.144149908130612 0.000856140982438327 NA NA NA hsa-miR-503-5p CCND2 1.97129438815516 2.1704434283035e-09 -1.64140990579885 1.49666938681079e-12 MirTarget -0.132569636435255 4.69239346000773e-05 25860935 We then identified two targets of miR-503 CCND2 and CCND3 breast cancer hsa-miR-550a-5p CCND2 0.59977150019756 0.0314775340172755 -1.64140990579885 1.49666938681079e-12 MirTarget -0.220699899618513 1.33146855439522e-08 NA NA NA hsa-miR-589-3p CCND2 1.34253876396688 1.84935927493927e-05 -1.64140990579885 1.49666938681079e-12 mirMAP -0.194613807523332 3.68596504229146e-08 NA NA NA hsa-miR-590-3p CCND2 0.83851360565783 0.00129224433453587 -1.64140990579885 1.49666938681079e-12 miRanda;mirMAP -0.133052154455084 0.00820830741469702 NA NA NA hsa-miR-590-5p CCND2 2.07441240363458 4.95240551694843e-14 -1.64140990579885 1.49666938681079e-12 mirMAP -0.258740782004531 5.16823341358779e-08 NA NA NA hsa-miR-660-5p CCND2 2.04875198906126 1.08269480928897e-17 -1.64140990579885 1.49666938681079e-12 mirMAP -0.145565210932688 0.00131443056428649 NA NA NA hsa-miR-7-1-3p CCND2 2.61364240402652 1.98959237815786e-32 -1.64140990579885 1.49666938681079e-12 mirMAP -0.259792711431322 7.83559584811719e-08 NA NA NA hsa-miR-877-5p CCND2 -0.370234513208225 0.20670834111988 -1.64140990579885 1.49666938681079e-12 miRNAWalker2_validate -0.150269749089241 5.7135351515868e-05 NA NA NA hsa-miR-93-5p CCND2 1.50844106515467 1.83836866996875e-12 -1.64140990579885 1.49666938681079e-12 miRNATAP -0.414585687663892 1.04746846150745e-17 NA NA NA hsa-miR-96-5p CCND2 3.0381097138467 4.40362891630201e-24 -1.64140990579885 1.49666938681079e-12 TargetScan;miRNATAP -0.357833634781266 1.13611538125112e-20 NA NA NA hsa-miR-320b CCND3 0.226640952564488 0.378818692487242 -0.858556164090156 9.93688486289821e-06 miRanda -0.106740567141186 0.00235090988932412 NA NA NA hsa-miR-421 CCND3 0.170525317701774 0.535277026680289 -0.858556164090156 9.93688486289821e-06 PITA;miRanda -0.120402813664522 0.000730915299268324 NA NA NA hsa-miR-96-5p CCND3 3.0381097138467 4.40362891630201e-24 -0.858556164090156 9.93688486289821e-06 TargetScan -0.12470872406597 0.000146574618288945 NA NA NA hsa-miR-125b-5p CCNE1 -0.548859243919575 0.0107224406584463 2.99717740665025 1.61069658019784e-19 miRNAWalker2_validate -0.212969225547095 0.00407731324503497 NA NA NA hsa-miR-195-5p CCNE1 -1.01577502605386 4.80814718341729e-05 2.99717740665025 1.61069658019784e-19 miRNAWalker2_validate;MirTarget;miRNATAP -0.51804360034979 1.42698078497522e-15 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively breast cancer hsa-miR-26a-5p CCNE1 -0.126411409001078 0.440028840408711 2.99717740665025 1.61069658019784e-19 miRNAWalker2_validate;miRTarBase;miRNATAP -0.695101497950461 4.5037170303388e-13 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen breast cancer hsa-miR-497-5p CCNE1 -0.0546347378264729 0.786205564901684 2.99717740665025 1.61069658019784e-19 MirTarget;miRNATAP -0.495681038343954 2.32850749141189e-10 25909221;24112607;24909281 The effect of simultaneous overexpression of miR-497 and miR-34a on the inhibition of cell proliferation colony formation and tumor growth and the downregulation of cyclin E1 was stronger than the effect of each miRNA alone; The synergistic actions of miR-497 and miR-34a partly correlated with cyclin E1 levels; These results indicate cyclin E1 is downregulated by both miR-497 and miR-34a which synergistically retard the growth of human lung cancer cells;Western blot assays confirmed that overexpression of miR-497 reduced cyclin E1 protein levels; Inhibited cellular growth suppressed cellular migration and invasion and G1 cell cycle arrest were observed upon overexpression of miR-497 in cells possibly by targeting cyclin E1;miR 497 suppresses proliferation of human cervical carcinoma HeLa cells by targeting cyclin E1; Furthermore the target effect of miR-497 on the CCNE1 was identified by dual-luciferase reporter assay system qRT-PCR and Western blotting; Over-expressed miR-497 in HeLa cells could suppress cell proliferation by targeting CCNE1 ;; lung cancer;breast cancer;cervical and endocervical cancer hsa-let-7a-3p CCNE2 0.167285443861993 0.431834813181487 2.14869777933212 3.82193505863706e-13 mirMAP -0.219072556802333 0.00307083362438944 NA NA NA hsa-let-7b-3p CCNE2 -1.81889978084306 6.9913416210266e-19 2.14869777933212 3.82193505863706e-13 mirMAP -0.490706485648775 1.99669157811241e-14 NA NA NA hsa-miR-126-3p CCNE2 0.397563736477277 0.115641762947829 2.14869777933212 3.82193505863706e-13 miRNAWalker2_validate -0.150847603483629 0.0065596481993981 NA NA NA hsa-miR-26a-5p CCNE2 -0.126411409001078 0.440028840408711 2.14869777933212 3.82193505863706e-13 miRNAWalker2_validate;miRTarBase;miRNATAP -0.509665959363437 2.11729025570925e-09 24116110;21901171 The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression poor survival;progression pancreatic cancer;acute myeloid leukemia hsa-miR-26b-5p CCNE2 0.72362441215247 4.7794659748036e-05 2.14869777933212 3.82193505863706e-13 miRNATAP -0.221903049454022 0.0047653538397741 NA NA NA hsa-miR-3065-5p CCNE2 0.653308707552535 0.0999497219778851 2.14869777933212 3.82193505863706e-13 mirMAP -0.199731594807246 1.35834639539203e-07 NA NA NA hsa-miR-30a-5p CCNE2 -0.924084264430689 0.000762030454634728 2.14869777933212 3.82193505863706e-13 miRNATAP -0.485926886026448 9.30670075166704e-24 NA NA NA hsa-miR-30b-5p CCNE2 0.358144314839612 0.138026229059594 2.14869777933212 3.82193505863706e-13 miRNAWalker2_validate;miRTarBase -0.201650464117881 0.000503320898048745 22384020 A luciferase-based reporter assay demonstrated that miR-30b post-transcriptionally reduced 27% p = 0.005 of the gene expression by interacting with two binding sites in the 3'-UTR of CCNE2; The upregulation of miR-30b by trastuzumab may play a biological role in trastuzumab-induced cell growth inhibition by targeting CCNE2 breast cancer hsa-miR-30c-5p CCNE2 -0.327319105755825 0.123595832152687 2.14869777933212 3.82193505863706e-13 miRNATAP -0.441580113864178 9.21074303399811e-12 NA NA NA hsa-miR-30d-5p CCNE2 -0.920901858717441 3.50898334321668e-05 2.14869777933212 3.82193505863706e-13 miRNATAP -0.348831475795763 1.65705272947657e-08 25843294 MicroRNA 30d 5p inhibits tumour cell proliferation and motility by directly targeting CCNE2 in non small cell lung cancer; In addition the re-introduction of CCNE2 expression antagonised the inhibitory effects of miR-30d-5p on the capacity of NSCLC cells for proliferation and motility motility lung squamous cell cancer hsa-miR-34a-5p CCNE2 1.40588612517769 8.60097477768592e-12 2.14869777933212 3.82193505863706e-13 miRNAWalker2_validate;miRTarBase;miRNATAP -0.195460410714665 0.00336778531948037 NA NA NA hsa-miR-34c-5p CCNE2 -1.00125440032112 0.0724432896090357 2.14869777933212 3.82193505863706e-13 miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP -0.107375543427311 4.3380723232889e-05 NA NA NA hsa-miR-514a-3p CCNE2 -0.62130231811134 0.313738530078239 2.14869777933212 3.82193505863706e-13 miRNATAP -0.174092237043764 3.53454317603187e-12 NA NA NA hsa-miR-1301-3p CCNH 0.845987603184611 0.000579808501723616 -0.171827171105742 0.119369136814293 miRNAWalker2_validate -0.132103395779049 5.26235835438113e-11 NA NA NA hsa-miR-141-3p CDC14A 3.36993755486106 5.42939251147195e-32 -1.19387029354728 1.35717350559378e-09 TargetScan;miRNATAP -0.188361894187529 1.80246489415133e-10 NA NA NA hsa-miR-324-5p CDC14A 1.06955541886548 5.39722006604758e-05 -1.19387029354728 1.35717350559378e-09 miRanda -0.120595714300697 0.000482594860318218 NA NA NA hsa-miR-576-5p CDC14A 1.02693643167056 1.14846964470173e-06 -1.19387029354728 1.35717350559378e-09 mirMAP -0.126831349091264 0.00346785213115847 NA NA NA hsa-miR-590-5p CDC14B 2.07441240363458 4.95240551694843e-14 -0.342258623909946 0.0166442329491366 miRanda -0.101273070182124 0.000437551700287973 NA NA NA hsa-miR-23b-3p CDC20 -0.070273068040148 0.620585267977425 3.63236139151121 1.13046017962008e-25 miRNAWalker2_validate -0.664038025793131 2.6514079304742e-08 NA NA NA hsa-miR-30a-5p CDC20 -0.924084264430689 0.000762030454634728 3.63236139151121 1.13046017962008e-25 miRNAWalker2_validate -0.659948772275131 1.57721958788694e-30 NA NA NA hsa-let-7a-5p CDC25A -1.37014061604018 3.11451492971224e-14 2.44399856980084 2.04104469577105e-16 MirTarget;TargetScan;miRNATAP -0.529734301739721 1.76260672591836e-12 NA NA NA hsa-let-7b-5p CDC25A -1.62016148171663 1.56547487335694e-15 2.44399856980084 2.04104469577105e-16 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.583086407256029 4.30179038140777e-19 NA NA NA hsa-let-7c-5p CDC25A -2.14139413005852 1.66416999341685e-18 2.44399856980084 2.04104469577105e-16 MirTarget -0.547152659829696 7.65534438813358e-25 25909324 MicroRNA let 7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma; The aim of the present study was to determine whether the cell cycle regulator CDC25A is involved in the antitumor effect of let-7c in HCC; The luciferase reporter assay showed that CDC25A was a direct target of let-7c and that let-7c inhibited the expression of CDC25A protein by directly targeting its 3' UTR; In conclusion this study indicates that let-7c suppresses HCC progression possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules progression liver cancer hsa-let-7f-5p CDC25A -0.0523311272618407 0.83407808268787 2.44399856980084 2.04104469577105e-16 MirTarget;miRNATAP -0.170402370356879 0.00273422905629893 NA NA NA hsa-miR-195-5p CDC25A -1.01577502605386 4.80814718341729e-05 2.44399856980084 2.04104469577105e-16 MirTarget;miRNATAP -0.466642624446018 6.04783935204968e-16 NA NA NA hsa-miR-30b-3p CDC25A -1.20976737190106 2.63726511331003e-06 2.44399856980084 2.04104469577105e-16 MirTarget -0.305923981633284 1.37629804343572e-08 NA NA NA hsa-miR-34c-5p CDC25A -1.00125440032112 0.0724432896090357 2.44399856980084 2.04104469577105e-16 miRNATAP -0.147202623136546 2.44091599766448e-08 21321636 Ectopic expression of miR-449b and miR-34c resulted in lowered adhesion activities by 28%-34% and in cell cycle arrests with increased cell number of 15.62% and 15.71% in G1 and with decreased cell number of 15.96% and 16.56% in S Cell cycle related proteins CDK6 and CDC25A were down-regulated; The decreases of CDK6 and CDC25A by miR-449b were 39% and 22% respecyively; 49% and 32% by miR-34c respectively ovarian cancer hsa-miR-497-5p CDC25A -0.0546347378264729 0.786205564901684 2.44399856980084 2.04104469577105e-16 MirTarget;miRNATAP -0.564662345860154 1.83644591603038e-16 NA NA NA hsa-let-7a-5p CDC25B -1.37014061604018 3.11451492971224e-14 0.434458604444449 0.03249037912714 miRNAWalker2_validate -0.283049852145059 1.58468224550705e-08 NA NA NA hsa-miR-200b-3p CDC27 1.55157578247391 4.83790020897188e-09 0.0799388452420038 0.431140873869534 TargetScan -0.11116768196351 5.15538761724989e-11 NA NA NA hsa-miR-362-5p CDC27 0.658947634569393 0.0243306847205756 0.0799388452420038 0.431140873869534 miRNATAP -0.105951233335384 3.19225589460912e-11 NA NA NA hsa-miR-497-5p CDC27 -0.0546347378264729 0.786205564901684 0.0799388452420038 0.431140873869534 miRNATAP -0.201935513091972 1.4511130362118e-19 NA NA NA hsa-miR-26a-5p CDC6 -0.126411409001078 0.440028840408711 3.07280830186032 2.61005341863179e-21 miRNAWalker2_validate -0.731323800617234 6.56506901225912e-15 25100863;27158389 Here it is demonstrated that miR26a and miR26b inhibit replication licensing and the proliferation migration and invasion of lung cancer cells by targeting CDC6; The current study suggests that miR26a miR26b and CDC6 and factors regulating their expression represent potential cancer diagnostic and prognostic markers as well as anticancer targets;miR 26a inhibits the proliferation of ovarian cancer cells via regulating CDC6 expression; Bioinformatics analysis revealed Cdc6 was a target gene of miR-26a; dual-luciferase assay and validation assay showed miR-26a could act on the 3'UTR of Cdc6 to regulate Cdc6 expression; These findings suggest that miR-26a may act on the 3'UTR of Cdc6 to regulate Cdc6 expression which then inhibit the proliferation of ovarian cancer cells and induce their apoptosis ; lung cancer;ovarian cancer hsa-miR-361-3p CDC6 0.0988926195529967 0.549128728500555 3.07280830186032 2.61005341863179e-21 miRNAWalker2_validate -0.407000511704999 1.90011425593916e-05 NA NA NA hsa-let-7a-5p CDC7 -1.37014061604018 3.11451492971224e-14 1.26649131114915 3.46452988769159e-08 miRNAWalker2_validate -0.323101393122854 1.81404955459471e-08 NA NA NA hsa-miR-3065-3p CDC7 0.381740717819351 0.30795546546997 1.26649131114915 3.46452988769159e-08 MirTarget -0.179254315783508 1.88704609676891e-10 NA NA NA hsa-miR-338-5p CDC7 -1.83316380675941 4.03269924759167e-07 1.26649131114915 3.46452988769159e-08 mirMAP -0.193874808748599 1.37004186430784e-11 NA NA NA hsa-miR-455-5p CDC7 1.36946341828134 5.05118627562807e-08 1.26649131114915 3.46452988769159e-08 miRanda -0.171408913438547 0.000423548017869876 NA NA NA hsa-miR-23b-3p CDK2 -0.070273068040148 0.620585267977425 0.335081436185588 0.0196934506015732 miRNAWalker2_validate -0.320796841599285 4.19225271403267e-12 NA NA NA hsa-miR-26b-5p CDK2 0.72362441215247 4.7794659748036e-05 0.335081436185588 0.0196934506015732 miRNAWalker2_validate -0.127461620300032 0.000584290801690183 NA NA NA hsa-miR-145-5p CDK4 -1.34926078156437 2.63526538800669e-07 0.737437814725925 6.46735685355202e-06 miRNAWalker2_validate;miRTarBase -0.151032894863878 9.5680433026529e-08 21092188 Furthermore we found that CDK4 was regulated by miR-145 in cell cycle control lung squamous cell cancer hsa-miR-195-5p CDK4 -1.01577502605386 4.80814718341729e-05 0.737437814725925 6.46735685355202e-06 miRNAWalker2_validate;miRTarBase -0.113117227761123 0.000369485847021713 NA NA NA hsa-miR-320a CDK4 -0.961144925954715 1.62478794429204e-08 0.737437814725925 6.46735685355202e-06 miRNAWalker2_validate -0.198117291941419 6.62226154091084e-06 NA NA NA hsa-miR-141-3p CDK6 3.36993755486106 5.42939251147195e-32 -0.634679756888932 0.0174689602657709 TargetScan;miRNATAP -0.160612180698081 5.76268904101641e-05 NA NA NA hsa-miR-148a-3p CDK6 2.30885799126944 1.95226081368985e-21 -0.634679756888932 0.0174689602657709 mirMAP -0.140512406763982 0.00377970382659687 NA NA NA hsa-miR-15a-5p CDK6 1.62575353599172 1.55312121019827e-19 -0.634679756888932 0.0174689602657709 miRNATAP -0.213028438155036 0.00125907527826487 NA NA NA hsa-miR-16-1-3p CDK6 1.50034693398929 6.63958242991125e-10 -0.634679756888932 0.0174689602657709 mirMAP -0.187334541166986 0.00249778145407185 NA NA NA hsa-miR-182-5p CDK6 3.21839823004635 5.13049145201115e-39 -0.634679756888932 0.0174689602657709 mirMAP -0.195465673682201 1.86720454693084e-05 NA NA NA hsa-miR-200a-3p CDK6 3.14766878548496 1.32850889777422e-21 -0.634679756888932 0.0174689602657709 miRNATAP -0.172932973424539 1.8796595520804e-06 24009066 microRNA 200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6 liver cancer hsa-miR-200b-3p CDK6 1.55157578247391 4.83790020897188e-09 -0.634679756888932 0.0174689602657709 mirMAP -0.168627583367613 0.000217208517169461 NA NA NA hsa-miR-21-5p CDK6 4.38165933891779 1.52536633902505e-92 -0.634679756888932 0.0174689602657709 miRNAWalker2_validate;mirMAP -0.148024006269382 0.00157509032784336 NA NA NA hsa-miR-23b-3p CDK6 -0.070273068040148 0.620585267977425 -0.634679756888932 0.0174689602657709 mirMAP -0.23876595315757 0.0067366952470222 NA NA NA hsa-miR-27b-3p CDK6 0.236438984240408 0.12263510345883 -0.634679756888932 0.0174689602657709 mirMAP -0.290275286674932 0.000346874480244186 NA NA NA hsa-miR-27b-5p CDK6 1.03511957999268 7.86187917705303e-11 -0.634679756888932 0.0174689602657709 mirMAP -0.218863599231384 0.00422822542967776 NA NA NA hsa-miR-29b-3p CDK6 3.10527711861309 3.01242507282711e-32 -0.634679756888932 0.0174689602657709 miRNAWalker2_validate;miRTarBase;miRNATAP -0.177579122887668 4.47727335928492e-05 23591808;23245396;25472644;26180082;27230400;20086245 Here we have identified the oncogene cyclin-dependent protein kinase 6 CDK6 as a direct target of miR-29b in lung cancer;The IFN-γ-induced G1-arrest of melanoma cells involves down-regulation of CDK6 which we proved to be a direct target of miR-29 in these cells;Moreover miR-29b inhibited the expression of MCL1 and CDK6;Knockdown of NTSR1 increased the expression of miR-29b-1 and miR-129-3p which were responsible for the decreased CDK6 expression;MiR 29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6; In this study we investigated the role of miR-29b as a novel regulator of CDK6 using bioinformatics methods; We demonstrated that CDK6 can be downregulated by miR-29b via binding to the 3'-UTR region in osteosarcoma cells; Furthermore we identified an inverse correlation between miR-29b and CDK6 protein levels in osteosarcoma tissues; The results revealed that miR-29b acts as a tumor suppressor of osteosarcoma by targeting CDK6 in the proliferation and migration processes;microRNA expression profile and identification of miR 29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma; Furthermore we demonstrate miR-29 inhibition of CDK6 protein and mRNA levels by direct binding to 3'-untranslated region; Inverse correlation between miR-29 and CDK6 was observed in MCL ;;;;; lung cancer;melanoma;colorectal cancer;glioblastoma;sarcoma;lymphoma hsa-miR-3065-5p CDK6 0.653308707552535 0.0999497219778851 -0.634679756888932 0.0174689602657709 mirMAP -0.22642349631217 6.97387440613112e-12 NA NA NA hsa-miR-30b-5p CDK6 0.358144314839612 0.138026229059594 -0.634679756888932 0.0174689602657709 mirMAP -0.297003306946081 3.8128721932856e-09 NA NA NA hsa-miR-30c-5p CDK6 -0.327319105755825 0.123595832152687 -0.634679756888932 0.0174689602657709 mirMAP -0.164968126318733 0.0045742419018014 NA NA NA hsa-miR-30d-3p CDK6 0.00396376345349925 0.986457040013182 -0.634679756888932 0.0174689602657709 mirMAP -0.371507952440074 1.92927097384112e-10 NA NA NA hsa-miR-30d-5p CDK6 -0.920901858717441 3.50898334321668e-05 -0.634679756888932 0.0174689602657709 mirMAP -0.319235369499537 4.17247463199845e-09 NA NA NA hsa-miR-30e-5p CDK6 1.60414100786743 3.78951090573667e-19 -0.634679756888932 0.0174689602657709 mirMAP -0.286452484165894 1.41651230242754e-05 NA NA NA hsa-miR-338-3p CDK6 0.726843067232002 0.0506251324215494 -0.634679756888932 0.0174689602657709 mirMAP -0.154832977052286 2.36104508154558e-06 NA NA NA hsa-miR-34a-5p CDK6 1.40588612517769 8.60097477768592e-12 -0.634679756888932 0.0174689602657709 miRNAWalker2_validate;miRTarBase;miRNATAP -0.243763697376835 2.99239665927089e-05 26104764;21702042 The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004;Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization ; lung cancer;bladder cancer hsa-miR-362-5p CDK6 0.658947634569393 0.0243306847205756 -0.634679756888932 0.0174689602657709 mirMAP -0.182028148769008 2.22030118459272e-05 NA NA NA hsa-miR-429 CDK6 2.3794516574089 1.72813419703734e-13 -0.634679756888932 0.0174689602657709 mirMAP;miRNATAP -0.15019667316567 0.000181432042876184 NA NA NA hsa-miR-660-5p CDK6 2.04875198906126 1.08269480928897e-17 -0.634679756888932 0.0174689602657709 mirMAP -0.160480938026846 0.00163906606751145 NA NA NA hsa-miR-664a-3p CDK6 0.443077463053857 0.0214248925850984 -0.634679756888932 0.0174689602657709 mirMAP -0.300162344123568 2.48177468084385e-06 NA NA NA hsa-miR-199a-5p CDK7 1.3057193856884 2.38429382751645e-08 0.509088595165427 7.4234216681883e-05 miRanda -0.114395746167986 4.32806341121223e-06 NA NA NA hsa-miR-423-3p CDK7 0.237880985943445 0.221744070846278 0.509088595165427 7.4234216681883e-05 miRNAWalker2_validate -0.101658521367554 0.000909077943704984 NA NA NA hsa-miR-106b-5p CDKN1A 1.47447672652218 1.32004094930462e-13 -0.989660104023605 3.33169106596478e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.227776235142808 2.11586866823657e-07 NA NA NA hsa-miR-17-5p CDKN1A 2.07078488653279 2.77403038572568e-19 -0.989660104023605 3.33169106596478e-07 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.155626227970113 3.32801748379634e-05 26482648;24989082 The low expressions of miR-17 and miR-92 families can maintain cisplatin resistance through the regulation of CDKN1A and RAD21;According to PicTar and Miranda algorithms which predicted CDKN1A p21 as a putative target of miR-17 a luciferase assay was performed and revealed that miR-17 directly targets the 3'-UTR of p21 mRNA drug resistance; lung squamous cell cancer;sarcoma hsa-miR-182-5p CDKN1A 3.21839823004635 5.13049145201115e-39 -0.989660104023605 3.33169106596478e-07 miRNAWalker2_validate -0.191273978004266 8.63402331622284e-09 NA NA NA hsa-miR-20a-5p CDKN1A 2.64649625616975 5.1469418982085e-27 -0.989660104023605 3.33169106596478e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.137674450234877 6.74026700667366e-05 26012475 Using the poorly tumorigenic and TGF-β-sensitive FET cell line that expresses low miR-20a levels we first confirmed that miR-20a downmodulated CDKN1A expression both at mRNA and protein level through direct binding to its 3'-UTR; Moreover besides modulating CDKN1A miR-20a blocked TGF-β-induced transactivation of its promoter without affecting the post-receptor activation of Smad3/4 effectors directly; Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex colon cancer hsa-miR-28-5p CDKN1A 1.19639196514745 4.59365801666536e-18 -0.989660104023605 3.33169106596478e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.202389894871562 0.0015056884290614 NA NA NA hsa-miR-93-5p CDKN1A 1.50844106515467 1.83836866996875e-12 -0.989660104023605 3.33169106596478e-07 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.165683989353739 5.62354734150849e-05 25633810 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC liver cancer hsa-miR-96-5p CDKN1A 3.0381097138467 4.40362891630201e-24 -0.989660104023605 3.33169106596478e-07 miRNAWalker2_validate;miRTarBase -0.146610096725374 7.80340952179366e-06 26582573 Upregulation of microRNA 96 and its oncogenic functions by targeting CDKN1A in bladder cancer; Bioinformatics prediction combined with luciferase reporter assay were used to verify whether the cyclin-dependent kinase inhibitor CDKN1A was a potential target gene of miR-96; According to the data of miRTarBase CDKN1A might be a candidate target gene of miR-96; In addition luciferase reporter and Western blot assays respectively demonstrated that miR-96 could bind to the putative seed region in CDKN1A mRNA 3'UTR and significantly reduce the expression level of CDKN1A protein; Moreover we found that the inhibition of miR-96 expression remarkably decreased cell proliferation and promoted cell apoptosis of BC cell lines which was consistent with the findings observed following the introduction of CDKN1A cDNA without 3'UTR restored miR-96; Upregulation of miR-96 may contribute to aggressive malignancy partly through suppressing CDKN1A protein expression in BC cells bladder cancer hsa-miR-590-3p CDKN1C 0.83851360565783 0.00129224433453587 -1.22831297933308 1.34794563419219e-07 miRanda -0.146905848762651 0.00324668183905974 NA NA NA hsa-miR-215-5p CDKN2A 0.116505586532384 0.8384722675454 1.92308660588306 0.00061855049856206 miRNAWalker2_validate -0.177578968663255 0.000710634851332846 NA NA NA hsa-miR-217 CDKN2B 1.88358668330143 3.93795605235061e-07 -1.64930350145125 4.56620277532412e-08 miRanda -0.114557575076438 0.00480836435183995 NA NA NA hsa-miR-335-3p CDKN2B 1.51116383169018 6.88553098788624e-13 -1.64930350145125 4.56620277532412e-08 mirMAP -0.250041261114888 0.000128723816290032 NA NA NA hsa-miR-375 CDKN2B 0.615547997686534 0.149199273675144 -1.64930350145125 4.56620277532412e-08 miRNAWalker2_validate;miRNATAP -0.191996908964639 3.49545303133141e-09 NA NA NA hsa-miR-429 CDKN2B 2.3794516574089 1.72813419703734e-13 -1.64930350145125 4.56620277532412e-08 miRanda -0.138721025178036 0.00258602925155939 NA NA NA hsa-miR-139-5p CHEK1 -2.26625553116965 7.22375119369519e-16 1.85259564745725 8.22396650402656e-14 miRanda -0.332742769048999 1.86178611104622e-17 NA NA NA hsa-miR-195-5p CHEK1 -1.01577502605386 4.80814718341729e-05 1.85259564745725 8.22396650402656e-14 MirTarget;miRNATAP -0.345574150233039 7.39222165825211e-13 25840419 MiR 195 suppresses non small cell lung cancer by targeting CHEK1; We discovered that CHEK1 was a direct target of miR-195 which decreased CHEK1 expression in lung cancer cells lung squamous cell cancer hsa-miR-320a CHEK1 -0.961144925954715 1.62478794429204e-08 1.85259564745725 8.22396650402656e-14 MirTarget;miRanda -0.279842886792326 4.08338178278489e-05 NA NA NA hsa-miR-326 CHEK1 -0.992397386750901 0.00335173765975096 1.85259564745725 8.22396650402656e-14 miRanda -0.121601688728903 0.000425451688060438 NA NA NA hsa-miR-497-5p CHEK1 -0.0546347378264729 0.786205564901684 1.85259564745725 8.22396650402656e-14 MirTarget;miRNATAP -0.487503389798205 7.93376609427637e-18 24464213 Checkpoint kinase 1 is negatively regulated by miR 497 in hepatocellular carcinoma; In silico analysis showed that CHEK1 was a candidate target of miR-497 which was previously found to be downregulated in HCC by us; To test whether miR-497 could bind to 3'untranslated region 3'UTR of CHEK1 luciferase reporter assay was conducted; The result revealed that miR-497 could bind to the 3'untranslated region 3'UTR of CHEK1 mRNA; Western blot showed that ectopic expression of miR-497 suppressed the CHEK1 expression and inhibition of miR-497 led to significant upregulation of CHEK1; Finally miR-497 expression was measured in the same 30 HCC samples and the correlation between miR-497 and CHEK1 was analyzed; The results indicated that miR-497 was downregulated in HCC and had a significant negative correlation with CHEK1; Taken together these results demonstrated that CHEK1 was negatively regulated by miR-497 and the overexpressed CHEK1 was resulted from the downregulated miR-497 in HCC which provided a potential molecular target for HCC therapy liver cancer hsa-miR-26b-5p CREBBP 0.72362441215247 4.7794659748036e-05 -0.117888962254313 0.332704389567094 miRNATAP -0.107061826766823 0.00062047995861088 NA NA NA hsa-miR-590-3p CREBBP 0.83851360565783 0.00129224433453587 -0.117888962254313 0.332704389567094 PITA;miRanda;mirMAP;miRNATAP -0.141497558961106 2.26793984615809e-08 NA NA NA hsa-miR-195-3p DBF4 -1.33068822339418 6.65427393047357e-09 1.25858648295357 1.90459695897916e-11 mirMAP -0.325108147777893 7.31711360347988e-19 NA NA NA hsa-miR-199a-5p DBF4 1.3057193856884 2.38429382751645e-08 1.25858648295357 1.90459695897916e-11 miRanda -0.167081966615485 6.26995084023241e-06 NA NA NA hsa-miR-199b-5p DBF4 2.13822205171062 4.56262988762436e-15 1.25858648295357 1.90459695897916e-11 miRanda -0.118016756928614 0.000160632898298509 NA NA NA hsa-miR-3065-3p DBF4 0.381740717819351 0.30795546546997 1.25858648295357 1.90459695897916e-11 MirTarget -0.16776614683116 2.91815086787464e-13 NA NA NA hsa-miR-30a-5p DBF4 -0.924084264430689 0.000762030454634728 1.25858648295357 1.90459695897916e-11 MirTarget -0.319162803235346 6.77815902100514e-26 NA NA NA hsa-miR-30b-5p DBF4 0.358144314839612 0.138026229059594 1.25858648295357 1.90459695897916e-11 MirTarget -0.258795507895619 4.6383516594289e-13 NA NA NA hsa-miR-30c-5p DBF4 -0.327319105755825 0.123595832152687 1.25858648295357 1.90459695897916e-11 MirTarget -0.346342463727049 7.49470804305754e-18 NA NA NA hsa-miR-30d-5p DBF4 -0.920901858717441 3.50898334321668e-05 1.25858648295357 1.90459695897916e-11 MirTarget -0.405139673224312 1.44563755111047e-27 NA NA NA hsa-miR-320a DBF4 -0.961144925954715 1.62478794429204e-08 1.25858648295357 1.90459695897916e-11 miRanda -0.230861517327034 6.28697199464701e-06 NA NA NA hsa-miR-486-5p DBF4 -4.38592782786845 2.75864166493846e-29 1.25858648295357 1.90459695897916e-11 miRanda -0.12714876998538 1.03517978497218e-09 NA NA NA hsa-let-7a-5p E2F1 -1.37014061604018 3.11451492971224e-14 1.30687901795677 2.85305435540948e-07 miRNAWalker2_validate -0.523028320943413 4.35351109487442e-17 NA NA NA hsa-miR-23b-3p E2F1 -0.070273068040148 0.620585267977425 1.30687901795677 2.85305435540948e-07 miRNAWalker2_validate -0.546105902057726 5.66664432411544e-11 NA NA NA hsa-miR-320a E2F1 -0.961144925954715 1.62478794429204e-08 1.30687901795677 2.85305435540948e-07 miRNATAP -0.235599876825095 0.000652376708117455 27721258 Inhibitory roles of miR 320 in osteosarcoma via regulating E2F1; qRT-PCR and Western blot were performed to access the molecular alteration of E2F1 miR-320 was decreased in human OsC cell lines; Besides we proved that miR-320 could directly regulate the expression of E2F1 in U2OS cells; These data suggested that miR-320 regulates the proliferation and cell cycle by targeting E2F1 in human OsC progression progression sarcoma hsa-miR-330-3p E2F1 -0.716924999893351 0.000796236278616087 1.30687901795677 2.85305435540948e-07 miRNAWalker2_validate;miRTarBase;PITA;miRNATAP -0.181067595310502 0.00108608916113551 19597470 MicroRNA 330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1 mediated suppression of Akt phosphorylation; Bioinformatics analyses reveal a conserved target site for miR-330 in the 3'-untranslated region UTR of E2F1 at nucleotides 1018-1024; In addition the expression level of miR-330 and E2F1 was inversely correlated in cell lines and prostate cancer specimens; Collectively this is the first study to show that E2F1 is negatively regulated by miR-330 and also show that miR-330 induces apoptosis in prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation prostate cancer hsa-let-7a-5p E2F2 -1.37014061604018 3.11451492971224e-14 2.22473169258522 4.76223979917143e-17 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.59573706347211 1.66629339804622e-19 20418948;25647078 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2;Tumor suppressive microRNA let 7a inhibits cell proliferation via targeting of E2F2 in osteosarcoma cells; When let-7a was transfected into OS cell lines the expression of E2F2 in the cells was greatly suppressed suggesting that E2F2 is a target of miRNA-let-7a in OS cells ; prostate cancer;sarcoma hsa-let-7b-5p E2F2 -1.62016148171663 1.56547487335694e-15 2.22473169258522 4.76223979917143e-17 MirTarget -0.545561722928263 5.43375623089007e-21 NA NA NA hsa-let-7c-5p E2F2 -2.14139413005852 1.66416999341685e-18 2.22473169258522 4.76223979917143e-17 MirTarget -0.455443908996083 1.71526674568561e-21 NA NA NA hsa-let-7d-5p E2F2 -0.618145137285851 6.06067642715858e-05 2.22473169258522 4.76223979917143e-17 MirTarget -0.257469141298577 0.00176045406375685 NA NA NA hsa-let-7e-5p E2F2 -0.749418249305995 7.34668338492227e-05 2.22473169258522 4.76223979917143e-17 MirTarget -0.209066193835266 0.0017490670212002 NA NA NA hsa-let-7f-5p E2F2 -0.0523311272618407 0.83407808268787 2.22473169258522 4.76223979917143e-17 MirTarget -0.229719420259207 5.29021193657211e-06 NA NA NA hsa-let-7g-5p E2F2 0.0837630831079359 0.583083118232597 2.22473169258522 4.76223979917143e-17 MirTarget -0.294601756249496 0.000436377320851044 NA NA NA hsa-miR-125a-5p E2F2 -1.04824536696301 3.97386082850476e-07 2.22473169258522 4.76223979917143e-17 MirTarget -0.41214141825195 4.0565304411813e-12 NA NA NA hsa-miR-125b-5p E2F2 -0.548859243919575 0.0107224406584463 2.22473169258522 4.76223979917143e-17 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.257118277436908 1.12925991595329e-05 22999819 miR 125b regulates the proliferation of glioblastoma stem cells by targeting E2F2; This study demonstrated that miR-125b plays important roles in regulating the proliferation of GSCs by directly targeting E2F2 glioblastoma hsa-miR-26a-5p E2F2 -0.126411409001078 0.440028840408711 2.22473169258522 4.76223979917143e-17 miRNATAP -0.50169847179153 5.96567290285655e-11 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC gastric cancer hsa-miR-3065-5p E2F2 0.653308707552535 0.0999497219778851 2.22473169258522 4.76223979917143e-17 mirMAP -0.126431836404637 0.000249821825763266 NA NA NA hsa-miR-30c-2-3p E2F2 -3.10905250533941 6.84550165664783e-27 2.22473169258522 4.76223979917143e-17 MirTarget -0.403144536758829 6.96796211228852e-25 NA NA NA hsa-miR-320a E2F2 -0.961144925954715 1.62478794429204e-08 2.22473169258522 4.76223979917143e-17 mirMAP -0.214246554307054 0.0036839090956258 NA NA NA hsa-miR-338-3p E2F2 0.726843067232002 0.0506251324215494 2.22473169258522 4.76223979917143e-17 mirMAP -0.164635940393152 1.00720020178923e-06 NA NA NA hsa-let-7b-5p E2F3 -1.62016148171663 1.56547487335694e-15 1.31313087353031 1.52975696061059e-17 miRNAWalker2_validate -0.256361604940122 7.51839509350746e-14 NA NA NA hsa-miR-125a-5p E2F3 -1.04824536696301 3.97386082850476e-07 1.31313087353031 1.52975696061059e-17 PITA;miRanda;miRNATAP -0.231046268559852 2.34945639683799e-11 NA NA NA hsa-miR-125b-5p E2F3 -0.548859243919575 0.0107224406584463 1.31313087353031 1.52975696061059e-17 miRNAWalker2_validate;miRTarBase;miRNATAP -0.118512018651672 0.000517593278629034 22523546;20549700 Moreover we demonstrated that the E2F3 was a direct target of miR-125b in breast cancer cells;E2F3 which was critical for G1/S transition and was overexpressed in most of poor-differentiated bladder cancers was identified as a target of miR-125b by luciferase assay; Introduction of miR-125b could reduce the expression of E2F3 protein but not the E2F3 mRNA ; breast cancer;bladder cancer hsa-miR-140-3p E2F3 -1.11373309124537 8.35257079443689e-14 1.31313087353031 1.52975696061059e-17 mirMAP -0.417776397603377 3.2248555401753e-19 NA NA NA hsa-miR-145-5p E2F3 -1.34926078156437 2.63526538800669e-07 1.31313087353031 1.52975696061059e-17 miRNATAP -0.155075953376092 1.44122488657241e-08 25762621 miR 145 mediates the antiproliferative and gene regulatory effects of vitamin D3 by directly targeting E2F3 in gastric cancer cells; Furthermore miR-145 expression was lower in tumors compared with matched normal samples and correlated with increased the E2F3 transcription factor protein staining gastric cancer hsa-miR-195-5p E2F3 -1.01577502605386 4.80814718341729e-05 1.31313087353031 1.52975696061059e-17 miRNAWalker2_validate;miRTarBase;miRNATAP -0.206862205005605 7.4310995671063e-12 22217655 We identified E2F3 and CCND3 as functional downstream targets of miR-195 in glioblastoma cells glioblastoma hsa-miR-221-3p E2F3 -0.0986794612964683 0.654454148658401 1.31313087353031 1.52975696061059e-17 miRNAWalker2_validate -0.129720255557418 0.00010053127184259 NA NA NA hsa-miR-30a-5p E2F3 -0.924084264430689 0.000762030454634728 1.31313087353031 1.52975696061059e-17 miRNATAP -0.210527395031701 3.8218078720225e-16 NA NA NA hsa-miR-30b-5p E2F3 0.358144314839612 0.138026229059594 1.31313087353031 1.52975696061059e-17 miRNATAP -0.12375812961254 4.57125141219664e-05 NA NA NA hsa-miR-30c-5p E2F3 -0.327319105755825 0.123595832152687 1.31313087353031 1.52975696061059e-17 miRNAWalker2_validate;miRNATAP -0.17627338662607 2.91216983565654e-07 NA NA NA hsa-miR-30d-5p E2F3 -0.920901858717441 3.50898334321668e-05 1.31313087353031 1.52975696061059e-17 miRNATAP -0.216987377793227 1.63546529634931e-11 NA NA NA hsa-miR-320a E2F3 -0.961144925954715 1.62478794429204e-08 1.31313087353031 1.52975696061059e-17 PITA;miRanda;miRNATAP -0.167439905127848 8.76065675662764e-05 NA NA NA hsa-miR-497-5p E2F3 -0.0546347378264729 0.786205564901684 1.31313087353031 1.52975696061059e-17 miRNATAP -0.206744088376571 1.14887004393304e-08 NA NA NA hsa-miR-23b-3p E2F4 -0.070273068040148 0.620585267977425 0.237455158304405 0.0138147627636484 miRNAWalker2_validate -0.138402916255728 1.06637342149306e-05 NA NA NA hsa-let-7a-5p E2F5 -1.37014061604018 3.11451492971224e-14 1.0925792440574 9.99702369509875e-07 MirTarget;TargetScan;miRNATAP -0.180805947141121 0.00131547511353865 NA NA NA hsa-let-7b-5p E2F5 -1.62016148171663 1.56547487335694e-15 1.0925792440574 9.99702369509875e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.254506091580133 2.39839778389386e-07 NA NA NA hsa-let-7c-5p E2F5 -2.14139413005852 1.66416999341685e-18 1.0925792440574 9.99702369509875e-07 MirTarget -0.232752664990009 9.2656833616494e-09 NA NA NA hsa-miR-1-3p E2F5 -1.48412019995919 0.000242034342580425 1.0925792440574 9.99702369509875e-07 MirTarget -0.132941948779636 1.48762691776353e-06 NA NA NA hsa-miR-181a-5p E2F5 -0.375429731222937 0.0562142867129802 1.0925792440574 9.99702369509875e-07 MirTarget;miRNATAP -0.253680319177407 1.4853763536728e-06 24529171 Mechanism investigation revealed that miR-181a inhibited the expression of transcription factor E2F5 by specifically targeting its mRNA 3'UTR; Moreover E2F5 inhibition induced cell growth and rescued the suppressive effect of miR-181a inhibitor on the proliferation of SMMC-7721 cells; Those results strongly suggested that HBV down-regulated E2F5 expression in part by up-regulating the expression of miR-181a; Up-regulation of miR-181a by HBV in hepatoma cells may contribute to the progression of HCC possibly by targeting E2F5 suggesting miR-181a plays important role in HCC development progression liver cancer hsa-miR-199a-5p E2F5 1.3057193856884 2.38429382751645e-08 1.0925792440574 9.99702369509875e-07 miRanda -0.152074795545498 0.000515780567108578 NA NA NA hsa-miR-199b-5p E2F5 2.13822205171062 4.56262988762436e-15 1.0925792440574 9.99702369509875e-07 miRanda -0.102686548976462 0.00550113874596158 NA NA NA hsa-miR-320a E2F5 -0.961144925954715 1.62478794429204e-08 1.0925792440574 9.99702369509875e-07 miRanda -0.280044770585433 3.30400868546574e-06 NA NA NA hsa-miR-34a-5p E2F5 1.40588612517769 8.60097477768592e-12 1.0925792440574 9.99702369509875e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.1924677685913 9.65229775436518e-05 26103003 MicroRNA 34a targets FMNL2 and E2F5 and suppresses the progression of colorectal cancer; FMNL2 and E2F5 were identified as direct targets of miR-34a; Reintroduction of FMNL2 or E2F5 without 3'UTR region reversed the inhibitory effects of miR-34a on cell proliferation and invasion; MiR-34a was down-regulated in CRC cells and inversely correlated with FMNL2 and E2F5 expressions; Our study suggests that miR-34a is an important tumor suppressor of CRC progression by targeting FMNL2 and E2F5 thus providing new insight into the molecular mechanisms underlying CRC progression and establishing a strong potential for the application of miR-34a as a novel therapeutic marker against CRC progression colorectal cancer hsa-miR-34c-5p E2F5 -1.00125440032112 0.0724432896090357 1.0925792440574 9.99702369509875e-07 MirTarget;PITA;miRanda;miRNATAP -0.117246699463624 1.25520279803684e-09 NA NA NA hsa-miR-361-5p E2F5 0.21454431962475 0.0800957579368424 1.0925792440574 9.99702369509875e-07 miRanda -0.277325715879496 0.00133094130375386 NA NA NA hsa-miR-378a-3p E2F5 -2.0140903990983 1.146745431034e-18 1.0925792440574 9.99702369509875e-07 miRNAWalker2_validate -0.288770550752668 1.9393392642128e-11 NA NA NA hsa-miR-140-5p EP300 0.669142684153918 0.000335928403032308 -0.24151027236021 0.0464135090934499 miRNAWalker2_validate -0.132228422733875 1.433084313638e-05 NA NA NA hsa-miR-142-5p EP300 1.29672439149353 4.0768822158894e-06 -0.24151027236021 0.0464135090934499 PITA;mirMAP;miRNATAP -0.121097424575162 7.94195192122639e-09 23342264 In contrast to the mouse p300 gene the human p300 gene was not found to be a target for miR-142-5p B cell lymphoma hsa-miR-26b-5p EP300 0.72362441215247 4.7794659748036e-05 -0.24151027236021 0.0464135090934499 miRNAWalker2_validate;miRNATAP -0.189576310673603 7.38860268524093e-10 NA NA NA hsa-miR-342-3p EP300 -0.128691966564961 0.561034080130801 -0.24151027236021 0.0464135090934499 MirTarget;PITA;miRanda;miRNATAP -0.163349604222849 4.45040401044694e-11 NA NA NA hsa-miR-590-3p EP300 0.83851360565783 0.00129224433453587 -0.24151027236021 0.0464135090934499 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.131033799746553 2.28041521831593e-07 NA NA NA hsa-miR-96-5p EP300 3.0381097138467 4.40362891630201e-24 -0.24151027236021 0.0464135090934499 TargetScan;miRNATAP -0.111815289027979 2.63317047880807e-08 NA NA NA hsa-let-7a-5p ESPL1 -1.37014061604018 3.11451492971224e-14 3.15403108240106 2.599225547017e-19 MirTarget;TargetScan -0.868563276783047 1.84182771355632e-23 NA NA NA hsa-let-7b-5p ESPL1 -1.62016148171663 1.56547487335694e-15 3.15403108240106 2.599225547017e-19 MirTarget -0.858821387241852 7.9579918424047e-30 NA NA NA hsa-let-7c-5p ESPL1 -2.14139413005852 1.66416999341685e-18 3.15403108240106 2.599225547017e-19 MirTarget -0.767020974413736 1.56157774674445e-35 NA NA NA hsa-let-7d-5p ESPL1 -0.618145137285851 6.06067642715858e-05 3.15403108240106 2.599225547017e-19 miRNAWalker2_validate;MirTarget -0.431171523560916 7.97827894142928e-05 NA NA NA hsa-let-7e-5p ESPL1 -0.749418249305995 7.34668338492227e-05 3.15403108240106 2.599225547017e-19 MirTarget -0.356891289235457 5.69218039422054e-05 NA NA NA hsa-let-7f-5p ESPL1 -0.0523311272618407 0.83407808268787 3.15403108240106 2.599225547017e-19 MirTarget -0.342018111949833 3.32696001492021e-07 NA NA NA hsa-let-7g-5p ESPL1 0.0837630831079359 0.583083118232597 3.15403108240106 2.599225547017e-19 MirTarget -0.464570107916198 2.97452208038877e-05 NA NA NA hsa-miR-125a-5p ESPL1 -1.04824536696301 3.97386082850476e-07 3.15403108240106 2.599225547017e-19 miRanda -0.591625483743008 6.03979498958455e-14 NA NA NA hsa-miR-34b-3p ESPL1 -1.69479533615636 0.00178266322862085 3.15403108240106 2.599225547017e-19 MirTarget -0.178627432832075 1.93255376958321e-08 NA NA NA hsa-miR-335-5p FZR1 -0.466533891325811 0.0676987038122831 0.261364802927296 0.0239418865856331 mirMAP -0.113377336575954 9.51485360298989e-07 NA NA NA hsa-miR-148b-3p GADD45A 0.483970528590224 0.0026495409465901 0.295807344757299 0.218383996212033 MirTarget -0.340126647931105 6.86475415101894e-07 NA NA NA hsa-miR-203a-3p GADD45A 1.06866854356847 0.00389979689199624 0.295807344757299 0.218383996212033 MirTarget -0.110751485098685 0.000186426373565797 NA NA NA hsa-miR-375 GADD45A 0.615547997686534 0.149199273675144 0.295807344757299 0.218383996212033 miRanda -0.117305912118485 4.96620623755307e-06 NA NA NA hsa-miR-324-3p GADD45B -0.0774700133118458 0.689226297032231 -1.592999067635 1.71286942854757e-12 MirTarget;miRNATAP -0.153520773002313 0.00557801960543285 NA NA NA hsa-miR-590-3p GADD45B 0.83851360565783 0.00129224433453587 -1.592999067635 1.71286942854757e-12 miRanda -0.128384670833959 0.0087523414105501 NA NA NA hsa-miR-127-3p GADD45G -0.723429813065737 0.0192747925933947 0.558251242266569 0.0699587843678354 miRanda;miRNATAP -0.177067134124427 0.000105410370152299 NA NA NA hsa-miR-146b-5p GSK3B 1.0922867893808 5.63754607494775e-06 -0.319504109269896 0.00509554373726706 miRanda -0.120312213108812 1.7975506993317e-08 NA NA NA hsa-miR-181a-5p GSK3B -0.375429731222937 0.0562142867129802 -0.319504109269896 0.00509554373726706 mirMAP -0.132846513131072 5.69040547461192e-07 NA NA NA hsa-miR-181b-5p GSK3B 0.668793269169928 0.000239998092406404 -0.319504109269896 0.00509554373726706 mirMAP -0.140685251831582 8.58107584485064e-07 NA NA NA hsa-miR-199a-5p GSK3B 1.3057193856884 2.38429382751645e-08 -0.319504109269896 0.00509554373726706 PITA;miRanda;miRNATAP -0.121841478766833 2.53412001096022e-08 NA NA NA hsa-miR-199b-5p GSK3B 2.13822205171062 4.56262988762436e-15 -0.319504109269896 0.00509554373726706 PITA;miRanda;miRNATAP -0.100321514688164 5.34622168763933e-08 NA NA NA hsa-miR-26b-5p GSK3B 0.72362441215247 4.7794659748036e-05 -0.319504109269896 0.00509554373726706 miRNATAP -0.157953924331919 5.91797033962096e-08 NA NA NA hsa-miR-29a-3p GSK3B 0.101650412194573 0.573201097011668 -0.319504109269896 0.00509554373726706 miRNATAP -0.116338386401065 6.72434775060363e-05 NA NA NA hsa-miR-29b-3p GSK3B 3.10527711861309 3.01242507282711e-32 -0.319504109269896 0.00509554373726706 miRTarBase;miRNATAP -0.120996712920378 3.47881082150066e-11 NA NA NA hsa-miR-342-3p GSK3B -0.128691966564961 0.561034080130801 -0.319504109269896 0.00509554373726706 miRanda -0.118246314250764 5.34302901573344e-07 NA NA NA hsa-miR-664a-3p GSK3B 0.443077463053857 0.0214248925850984 -0.319504109269896 0.00509554373726706 mirMAP -0.143789851437302 1.0690658876804e-07 NA NA NA hsa-let-7b-3p HDAC2 -1.81889978084306 6.9913416210266e-19 0.481699314512085 0.000208794879437368 mirMAP -0.128917458487588 4.2947942129416e-06 NA NA NA hsa-miR-145-5p HDAC2 -1.34926078156437 2.63526538800669e-07 0.481699314512085 0.000208794879437368 miRNAWalker2_validate -0.116933654939828 1.78172032315545e-07 23499894 MiR 145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer; Ectopic expression of miRNA mimics evidenced that miR-145 suppresses HDAC2 expression in HCC cells; In conclusion we suggest that loss or suppression of miR-145 may cause aberrant overexpression of HDAC2 and promote HCC tumorigenesis tumorigenesis liver cancer hsa-miR-146a-5p HDAC2 0.684701497250824 0.0105316554224149 0.481699314512085 0.000208794879437368 mirMAP -0.116155896773126 3.3162737787673e-07 NA NA NA hsa-miR-195-3p HDAC2 -1.33068822339418 6.65427393047357e-09 0.481699314512085 0.000208794879437368 mirMAP -0.195357388549024 8.37348527315314e-15 NA NA NA hsa-miR-30a-5p HDAC2 -0.924084264430689 0.000762030454634728 0.481699314512085 0.000208794879437368 mirMAP -0.139521617307515 6.67680836467364e-11 NA NA NA hsa-miR-30b-5p HDAC2 0.358144314839612 0.138026229059594 0.481699314512085 0.000208794879437368 mirMAP -0.155742665679859 1.98572228409988e-10 NA NA NA hsa-miR-30c-5p HDAC2 -0.327319105755825 0.123595832152687 0.481699314512085 0.000208794879437368 mirMAP -0.215380163020605 5.41780405511955e-15 NA NA NA hsa-miR-30d-3p HDAC2 0.00396376345349925 0.986457040013182 0.481699314512085 0.000208794879437368 mirMAP -0.135833789926764 2.20768432858745e-06 NA NA NA hsa-miR-30d-5p HDAC2 -0.920901858717441 3.50898334321668e-05 0.481699314512085 0.000208794879437368 mirMAP -0.210604532724355 5.93933616702534e-16 NA NA NA hsa-miR-320a HDAC2 -0.961144925954715 1.62478794429204e-08 0.481699314512085 0.000208794879437368 miRanda;mirMAP -0.11149686791334 0.0014235225212597 NA NA NA hsa-miR-139-5p MAD2L1 -2.26625553116965 7.22375119369519e-16 2.21525095291101 3.88050241165456e-15 miRanda -0.389610172352436 2.0816791974206e-18 NA NA NA hsa-miR-362-3p MAD2L1 0.194097672030785 0.52808475179225 2.21525095291101 3.88050241165456e-15 miRanda -0.156091504012814 0.0041967448055808 NA NA NA hsa-miR-139-5p MCM2 -2.26625553116965 7.22375119369519e-16 1.58911225074456 8.33309463396442e-12 miRanda -0.273463296071697 1.13768030160381e-13 NA NA NA hsa-miR-491-5p MCM2 -0.472928614372062 0.0683344127929203 1.58911225074456 8.33309463396442e-12 miRanda -0.112231155202865 0.00841001858956376 NA NA NA hsa-miR-34a-5p MCM3 1.40588612517769 8.60097477768592e-12 0.700109481006491 2.11728978813439e-06 miRNAWalker2_validate -0.103874449615396 0.0014592726911846 NA NA NA hsa-let-7b-5p MCM4 -1.62016148171663 1.56547487335694e-15 1.79508106891956 5.80556206249426e-14 miRNAWalker2_validate -0.468955972280617 2.31408865920133e-19 NA NA NA hsa-miR-23b-3p MCM4 -0.070273068040148 0.620585267977425 1.79508106891956 5.80556206249426e-14 MirTarget -0.391011394855476 1.10957375252889e-06 NA NA NA hsa-miR-320a MCM4 -0.961144925954715 1.62478794429204e-08 1.79508106891956 5.80556206249426e-14 miRNAWalker2_validate -0.344103206035123 1.38415242528484e-07 NA NA NA hsa-miR-338-3p MCM4 0.726843067232002 0.0506251324215494 1.79508106891956 5.80556206249426e-14 MirTarget;miRanda -0.208881092981181 2.07634431008381e-12 NA NA NA hsa-miR-34a-5p MCM4 1.40588612517769 8.60097477768592e-12 1.79508106891956 5.80556206249426e-14 miRNAWalker2_validate -0.196362576222486 0.000261182800861177 NA NA NA hsa-miR-486-5p MCM4 -4.38592782786845 2.75864166493846e-29 1.79508106891956 5.80556206249426e-14 miRanda -0.196540486450333 1.14359117098588e-13 NA NA NA hsa-miR-30c-2-3p MCM6 -3.10905250533941 6.84550165664783e-27 1.1713215880267 1.4781013196745e-09 MirTarget -0.239123398874626 6.31399923784143e-17 NA NA NA hsa-miR-320a MCM6 -0.961144925954715 1.62478794429204e-08 1.1713215880267 1.4781013196745e-09 miRanda -0.252867605000305 1.46447890295564e-06 NA NA NA hsa-miR-34a-5p MCM6 1.40588612517769 8.60097477768592e-12 1.1713215880267 1.4781013196745e-09 miRNAWalker2_validate -0.159225394733094 0.000221590373794701 NA NA NA hsa-miR-491-5p MCM6 -0.472928614372062 0.0683344127929203 1.1713215880267 1.4781013196745e-09 miRanda -0.115259550761154 0.00105704458073508 NA NA NA hsa-let-7b-5p MCM7 -1.62016148171663 1.56547487335694e-15 1.03612798352766 1.71713234333092e-08 miRNAWalker2_validate -0.330473925018445 9.85177088438153e-17 NA NA NA hsa-miR-450a-5p MDM2 1.94284269183615 1.52883075909271e-07 -0.018010582169941 0.916081437185101 mirMAP -0.108762560851161 1.20807844291087e-05 NA NA NA hsa-miR-484 MDM2 -0.228576985124486 0.244112867390855 -0.018010582169941 0.916081437185101 miRNAWalker2_validate -0.108672488962364 0.0069392239747807 NA NA NA hsa-miR-34a-5p MYC 1.40588612517769 8.60097477768592e-12 -0.594211476201249 0.0196490384548933 miRNAWalker2_validate;miRTarBase -0.160523406918217 0.0041257772904121 25572695;25686834;21460242;22159222;23640973;22830357;22235332 The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex ;;;malignant trasformation;worse prognosis;; bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer hsa-miR-429 MYC 2.3794516574089 1.72813419703734e-13 -0.594211476201249 0.0196490384548933 miRNAWalker2_validate -0.178099724014789 2.94573429210347e-06 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-30a-5p PCNA -0.924084264430689 0.000762030454634728 0.904074278874176 1.55659322342039e-07 miRNAWalker2_validate -0.23465238034608 9.10113139967228e-17 NA NA NA hsa-miR-338-5p PCNA -1.83316380675941 4.03269924759167e-07 0.904074278874176 1.55659322342039e-07 PITA -0.111988452712257 2.42482365552901e-07 NA NA NA hsa-let-7b-5p PLK1 -1.62016148171663 1.56547487335694e-15 3.05918482074134 4.71617191488889e-23 miRNAWalker2_validate -0.674920100583668 5.76500662453331e-23 NA NA NA hsa-miR-100-5p PLK1 0.423440403609931 0.104072937074013 3.05918482074134 4.71617191488889e-23 miRNAWalker2_validate;miRTarBase -0.150823247014139 0.0088448859542722 22120675;23151088;22246341;23842624;25537513;21636267 MiR 100 resensitizes docetaxel resistant human lung adenocarcinoma cells SPC A1 to docetaxel by targeting Plk1; Knock-down of Plk1 which was a direct target of miR-100 yielded similar effects as that of ectopic miR-100 expression; The inverse correlation between miR-100 and Plk1 expression was also detected in nude mice SPC-A1/DTX tumor xenografts and clinical lung adenocarcinoma tissues and was proved to be related with the in vivo response to docetaxel; Thus our results suggested that down-regulation of miR-100 could lead to Plk1 over-expression and eventually to docetaxel chemoresistance of human lung adenocarcinoma;MicroRNA 100 is a potential molecular marker of non small cell lung cancer and functions as a tumor suppressor by targeting polo like kinase 1; By using microRNA miR target prediction algorithms we identified miR-100 that might potentially bind the 3'-untranslated region of PLK1 transcripts; The purpose of this study was to investigate the roles of miR-100 and its association with PLK1 in NSCLC development; Finally the effects of miR-100 expression on growth apoptosis and cell cycle of NSCLC cells by posttranscriptionally regulating PLK1 expression were determined; Meanwhile miR-100 mimics could significantly inhibit PLK1 mRNA and protein expression and reduce the luciferase activity of a PLK1 3' untranslated region-based reporter construct in A549 cells; Furthermore small interfering RNA siRNA-mediated PLK1 downregulation could mimic the effects of miR-100 mimics while PLK1 overexpression could partially rescue the phenotypical changes of NSCLC cells induced by miR-100 mimics; Our findings indicate that low miR-100 may be a poor prognostic factor for NSCLC patients and functions as a tumor suppressor by posttranscriptionally regulating PLK1 expression;Together these results suggest that low miR-100 expression may be an independent poor prognostic factor and miR-100 can function as a tumor suppressor by targeting PLK1 in human EOCs;In HCC tissues miR-100 expression was inversely correlated with the expression of plk1 protein r = -0.418; P = 0.029; Therefore downregulation of miR-100 was correlated with progressive pathological feature and poor prognosis in HCC patients and miR-100 could function as a tumor suppressor by targeting plk1;Here we show that miR-100 inhibits maintenance and expansion of BrCSCs in basal-like cancer through Polo-like kinase1 Plk1 down-regulation;Reduced miR 100 expression in cervical cancer and precursors and its carcinogenic effect through targeting PLK1 protein; Through modulating miR-100 expression using miR-100 inhibitor or mimic in vitro cell growth cycle and apoptosis were tested separately by MTT or flow cytometry and meanwhile Polo-like kinase1 PLK1 mRNA and protein expressions were detected by qRT-PCR and immunoblotting; The expression of PLK1 in 125 cervical tissues was also examined by immunohistochemical staining and the correlation between miR-100 and PLK1 expression in the same tissues was analysed; The modulation of miR-100 expression remarkably influenced cell proliferation cycle and apoptosis as well as the level of PLK1 protein but not mRNA in vitro experiments; PLK1 expression was negatively correlated with miR-100 expression in CIN3 and cervical cancer tissues; The reduced miR-100 expression participates in the development of cervical cancer at least partly through loss of inhibition to target gene PLK1 which probably occurs in a relative late phase of carcinogenesis drug resistance;;;progression;worse prognosis;;tumorigenesis lung cancer;lung squamous cell cancer;ovarian cancer;liver cancer;breast cancer;cervical and endocervical cancer hsa-miR-455-5p PLK1 1.36946341828134 5.05118627562807e-08 3.05918482074134 4.71617191488889e-23 miRanda -0.232224376506942 0.000630294151840127 NA NA NA hsa-miR-486-5p PLK1 -4.38592782786845 2.75864166493846e-29 3.05918482074134 4.71617191488889e-23 miRanda -0.236891984194636 1.75425102379252e-11 NA NA NA hsa-miR-101-5p PRKDC -0.0265235292039296 0.917878791358577 0.866546334730074 1.23055862763112e-06 miRNAWalker2_validate;miRTarBase -0.242906934452106 9.53133746126844e-10 22014955 Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299 H1975 and A549 cells it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells lung squamous cell cancer hsa-miR-320a PRKDC -0.961144925954715 1.62478794429204e-08 0.866546334730074 1.23055862763112e-06 miRanda -0.184927047021916 0.000128520577689727 NA NA NA hsa-miR-455-5p PRKDC 1.36946341828134 5.05118627562807e-08 0.866546334730074 1.23055862763112e-06 miRanda -0.111471908095161 0.00314197384578653 NA NA NA hsa-let-7b-5p PTTG1 -1.62016148171663 1.56547487335694e-15 2.29967103891773 7.51122159159736e-16 miRNAWalker2_validate -0.57118685996351 5.74885645714688e-20 NA NA NA hsa-miR-26a-5p PTTG1 -0.126411409001078 0.440028840408711 2.29967103891773 7.51122159159736e-16 miRNAWalker2_validate -0.404247341427357 1.14869729062631e-06 NA NA NA hsa-miR-320a PTTG1 -0.961144925954715 1.62478794429204e-08 2.29967103891773 7.51122159159736e-16 miRNAWalker2_validate -0.317295396277166 5.71420954934744e-05 NA NA NA hsa-let-7a-3p RAD21 0.167285443861993 0.431834813181487 0.11334978665193 0.429901957673873 miRNATAP -0.136325916901246 8.63934555597985e-05 NA NA NA hsa-let-7b-3p RAD21 -1.81889978084306 6.9913416210266e-19 0.11334978665193 0.429901957673873 miRNATAP -0.150424299514659 1.00871477041867e-06 NA NA NA hsa-miR-139-5p RAD21 -2.26625553116965 7.22375119369519e-16 0.11334978665193 0.429901957673873 miRanda -0.165406915120153 8.00607912850128e-14 NA NA NA hsa-miR-140-5p RAD21 0.669142684153918 0.000335928403032308 0.11334978665193 0.429901957673873 miRanda -0.181797827677502 4.23508201879917e-07 NA NA NA hsa-miR-181a-5p RAD21 -0.375429731222937 0.0562142867129802 0.11334978665193 0.429901957673873 MirTarget;miRNATAP -0.220897042820432 2.24734363623548e-11 NA NA NA hsa-miR-181c-5p RAD21 0.529875814537156 0.0125885822998008 0.11334978665193 0.429901957673873 MirTarget;miRNATAP -0.128764392928801 3.16059347561739e-05 NA NA NA hsa-miR-195-3p RAD21 -1.33068822339418 6.65427393047357e-09 0.11334978665193 0.429901957673873 MirTarget;miRNATAP -0.196512246909544 1.55316028063015e-12 NA NA NA hsa-miR-199a-5p RAD21 1.3057193856884 2.38429382751645e-08 0.11334978665193 0.429901957673873 miRanda -0.204056619869216 5.17706811149877e-14 NA NA NA hsa-miR-199b-5p RAD21 2.13822205171062 4.56262988762436e-15 0.11334978665193 0.429901957673873 miRanda -0.167560961557535 2.41105326918182e-13 NA NA NA hsa-miR-3065-5p RAD21 0.653308707552535 0.0999497219778851 0.11334978665193 0.429901957673873 mirMAP -0.103896817534963 5.17091436745247e-09 NA NA NA hsa-miR-30a-3p RAD21 -2.54042202792785 2.9111625410859e-18 0.11334978665193 0.429901957673873 MirTarget -0.102142550004081 2.23671705430657e-06 NA NA NA hsa-miR-320a RAD21 -0.961144925954715 1.62478794429204e-08 0.11334978665193 0.429901957673873 MirTarget;PITA;miRanda;miRNATAP -0.148275367795267 0.000108046499075127 NA NA NA hsa-miR-362-3p RAD21 0.194097672030785 0.52808475179225 0.11334978665193 0.429901957673873 miRanda -0.101032862538439 0.000157857776351172 NA NA NA hsa-miR-502-3p RAD21 -0.262270070977708 0.161760375279961 0.11334978665193 0.429901957673873 MirTarget;PITA -0.109311200732076 0.00199182781638443 NA NA NA hsa-miR-511-5p RAD21 -0.299232651841262 0.292871281649728 0.11334978665193 0.429901957673873 MirTarget -0.113902961156429 7.25746817203579e-07 NA NA NA hsa-miR-106a-5p RB1 1.3902608059488 6.07931522284525e-05 -0.522284182507715 0.000468326890330552 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.115099475917591 1.3628351073122e-07 NA NA NA hsa-miR-106b-5p RB1 1.47447672652218 1.32004094930462e-13 -0.522284182507715 0.000468326890330552 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.137454202544637 4.51320413341319e-05 NA NA NA hsa-miR-125a-5p RB1 -1.04824536696301 3.97386082850476e-07 -0.522284182507715 0.000468326890330552 miRanda -0.108877135493928 0.000983316455063937 NA NA NA hsa-miR-1301-3p RB1 0.845987603184611 0.000579808501723616 -0.522284182507715 0.000468326890330552 MirTarget -0.132656297377882 1.74124875930846e-06 NA NA NA hsa-miR-130b-3p RB1 1.83046548750752 5.04753914574694e-13 -0.522284182507715 0.000468326890330552 miRNAWalker2_validate -0.164741887361937 2.36822632663646e-09 NA NA NA hsa-miR-17-5p RB1 2.07078488653279 2.77403038572568e-19 -0.522284182507715 0.000468326890330552 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.172435320319607 1.15078984867589e-09 NA NA NA hsa-miR-186-5p RB1 0.852175445703945 6.88885738584309e-10 -0.522284182507715 0.000468326890330552 mirMAP -0.240858807843776 1.02084992307171e-06 NA NA NA hsa-miR-199a-5p RB1 1.3057193856884 2.38429382751645e-08 -0.522284182507715 0.000468326890330552 miRanda -0.129817324847717 7.16386786171119e-06 NA NA NA hsa-miR-199b-5p RB1 2.13822205171062 4.56262988762436e-15 -0.522284182507715 0.000468326890330552 miRanda -0.106333975242502 1.29607366057096e-05 NA NA NA hsa-miR-20a-5p RB1 2.64649625616975 5.1469418982085e-27 -0.522284182507715 0.000468326890330552 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.163775255471668 3.19916952599445e-10 NA NA NA hsa-miR-20b-5p RB1 1.35770573270947 0.00260808530013016 -0.522284182507715 0.000468326890330552 MirTarget;miRNATAP -0.101125077295113 1.42555091355681e-10 NA NA NA hsa-miR-28-3p RB1 0.387144500601444 0.00777919765254534 -0.522284182507715 0.000468326890330552 PITA -0.141292815273916 0.0031771705307118 NA NA NA hsa-miR-29a-5p RB1 1.89519956688438 1.03453349363915e-11 -0.522284182507715 0.000468326890330552 MirTarget -0.111722993432052 0.000108313452486861 NA NA NA hsa-miR-30d-3p RB1 0.00396376345349925 0.986457040013182 -0.522284182507715 0.000468326890330552 MirTarget -0.102164048966928 0.00209869767453177 NA NA NA hsa-miR-342-3p RB1 -0.128691966564961 0.561034080130801 -0.522284182507715 0.000468326890330552 miRanda -0.149830018545608 1.3836155769582e-06 NA NA NA hsa-miR-361-5p RB1 0.21454431962475 0.0800957579368424 -0.522284182507715 0.000468326890330552 miRanda -0.172926869133665 0.00256681651577328 NA NA NA hsa-miR-576-5p RB1 1.02693643167056 1.14846964470173e-06 -0.522284182507715 0.000468326890330552 MirTarget -0.142981048417189 9.14810008867407e-06 NA NA NA hsa-miR-590-5p RB1 2.07441240363458 4.95240551694843e-14 -0.522284182507715 0.000468326890330552 miRanda -0.171114675369981 1.01128668410923e-08 NA NA NA hsa-miR-93-5p RB1 1.50844106515467 1.83836866996875e-12 -0.522284182507715 0.000468326890330552 miRNAWalker2_validate;MirTarget;miRNATAP -0.26136109506491 9.52919345920562e-18 NA NA NA hsa-miR-195-3p RBL1 -1.33068822339418 6.65427393047357e-09 0.634404631354986 0.00190589889440364 MirTarget;mirMAP -0.246101352339395 8.16780958911564e-10 NA NA NA hsa-miR-199a-5p RBL1 1.3057193856884 2.38429382751645e-08 0.634404631354986 0.00190589889440364 miRanda -0.148121927469146 0.000191824077217014 NA NA NA hsa-miR-199b-5p RBL1 2.13822205171062 4.56262988762436e-15 0.634404631354986 0.00190589889440364 miRanda -0.135426645614883 5.07585432118694e-05 NA NA NA hsa-miR-200b-3p RBL1 1.55157578247391 4.83790020897188e-09 0.634404631354986 0.00190589889440364 MirTarget -0.144779859979039 3.31001508506389e-05 NA NA NA hsa-miR-200c-3p RBL1 0.380533388300368 0.0842181838538353 0.634404631354986 0.00190589889440364 MirTarget -0.17521171939851 4.18558054188112e-05 NA NA NA hsa-miR-106a-5p RBL2 1.3902608059488 6.07931522284525e-05 -0.516492077682474 5.92305056757779e-05 MirTarget;miRNATAP -0.13392820224047 5.92164837110696e-13 24045973 Among many miR-106a predicated target genes p130 RBL2 an retinoblastoma Rb tumor suppressor family member was not only confirmed as a specific target of miR-106a but also related to tumor growth and differentiation; The importance of mir-106a and RBL2 was further demonstrated in vivo in which SKOV3 cells overexpressing miR-106a formed poorly differentiated carcinomas and had reduced RBL2 levels differentiation ovarian cancer hsa-miR-106b-5p RBL2 1.47447672652218 1.32004094930462e-13 -0.516492077682474 5.92305056757779e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.215341567706376 3.66006092380862e-14 NA NA NA hsa-miR-17-5p RBL2 2.07078488653279 2.77403038572568e-19 -0.516492077682474 5.92305056757779e-05 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.186905102067222 9.65217395879901e-15 NA NA NA hsa-miR-20a-5p RBL2 2.64649625616975 5.1469418982085e-27 -0.516492077682474 5.92305056757779e-05 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.134989231144882 1.97878935904001e-09 NA NA NA hsa-miR-335-3p RBL2 1.51116383169018 6.88553098788624e-13 -0.516492077682474 5.92305056757779e-05 MirTarget -0.132537789684453 1.3444724815766e-06 NA NA NA hsa-miR-421 RBL2 0.170525317701774 0.535277026680289 -0.516492077682474 5.92305056757779e-05 miRanda -0.116350101440375 6.13779131365422e-07 NA NA NA hsa-miR-576-5p RBL2 1.02693643167056 1.14846964470173e-06 -0.516492077682474 5.92305056757779e-05 MirTarget;PITA -0.141843634503635 3.03298315521095e-07 NA NA NA hsa-miR-590-3p RBL2 0.83851360565783 0.00129224433453587 -0.516492077682474 5.92305056757779e-05 miRanda -0.141913330574948 1.52520869660665e-07 NA NA NA hsa-miR-93-5p RBL2 1.50844106515467 1.83836866996875e-12 -0.516492077682474 5.92305056757779e-05 MirTarget;miRNATAP -0.193013530881052 3.65814480460646e-13 NA NA NA hsa-miR-454-3p SKP1 1.49453641052169 4.46235742871434e-09 -0.173813980331543 0.121763281653782 MirTarget -0.119595485764239 4.0867597278602e-07 NA NA NA hsa-miR-26a-5p SKP2 -0.126411409001078 0.440028840408711 0.717491763754031 0.00193527376559042 MirTarget -0.344578615119354 1.32474185351954e-07 NA NA NA hsa-miR-26b-5p SKP2 0.72362441215247 4.7794659748036e-05 0.717491763754031 0.00193527376559042 MirTarget -0.182482761499169 0.00237182034241061 NA NA NA hsa-miR-30a-5p SKP2 -0.924084264430689 0.000762030454634728 0.717491763754031 0.00193527376559042 MirTarget;miRNATAP -0.251277395174838 4.1522860461416e-11 NA NA NA hsa-miR-30b-5p SKP2 0.358144314839612 0.138026229059594 0.717491763754031 0.00193527376559042 MirTarget;miRNATAP -0.321261127428265 1.17677874163696e-13 NA NA NA hsa-miR-30c-5p SKP2 -0.327319105755825 0.123595832152687 0.717491763754031 0.00193527376559042 MirTarget;miRNATAP -0.309574792849125 4.67979990392473e-10 NA NA NA hsa-miR-30d-5p SKP2 -0.920901858717441 3.50898334321668e-05 0.717491763754031 0.00193527376559042 MirTarget;miRNATAP -0.354486329103118 2.75377796795053e-14 NA NA NA hsa-miR-146b-5p SMAD2 1.0922867893808 5.63754607494775e-06 -0.303598966729702 0.0159514222596008 mirMAP -0.124747200476988 1.31693635704313e-07 NA NA NA hsa-miR-181a-5p SMAD2 -0.375429731222937 0.0562142867129802 -0.303598966729702 0.0159514222596008 mirMAP -0.100760447867236 0.000646706434692283 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 0.668793269169928 0.000239998092406404 -0.303598966729702 0.0159514222596008 mirMAP -0.12955227917762 4.345362949562e-05 NA NA NA hsa-miR-361-5p SMAD2 0.21454431962475 0.0800957579368424 -0.303598966729702 0.0159514222596008 MirTarget -0.182189359256109 0.000148630910578159 NA NA NA hsa-miR-362-5p SMAD2 0.658947634569393 0.0243306847205756 -0.303598966729702 0.0159514222596008 mirMAP -0.106469252000328 1.13100823986564e-07 NA NA NA hsa-miR-450b-5p SMAD2 1.69248953402469 1.96052058003353e-07 -0.303598966729702 0.0159514222596008 mirMAP -0.113530038108809 4.67112154448759e-09 NA NA NA hsa-miR-501-5p SMAD2 0.411357595674671 0.10435288464149 -0.303598966729702 0.0159514222596008 mirMAP -0.107502701254072 2.2464520729965e-06 NA NA NA hsa-miR-532-5p SMAD2 0.576620898517708 0.0023245812680956 -0.303598966729702 0.0159514222596008 MirTarget -0.12142437459949 6.98911386285879e-05 NA NA NA hsa-miR-542-3p SMAD2 1.62226640768239 2.6427102465476e-10 -0.303598966729702 0.0159514222596008 PITA -0.122748876655511 2.00012298893724e-08 NA NA NA hsa-miR-16-5p SMAD3 0.749619098384047 4.11649450706988e-06 -0.104935015261858 0.513761397736816 MirTarget -0.134568029960143 0.00296658337663515 NA NA NA hsa-miR-17-5p SMAD3 2.07078488653279 2.77403038572568e-19 -0.104935015261858 0.513761397736816 miRNAWalker2_validate -0.114025973647647 0.000202733731547773 NA NA NA hsa-miR-30d-3p SMAD3 0.00396376345349925 0.986457040013182 -0.104935015261858 0.513761397736816 mirMAP -0.133925007589118 0.000158089768147608 NA NA NA hsa-miR-335-3p SMAD3 1.51116383169018 6.88553098788624e-13 -0.104935015261858 0.513761397736816 mirMAP -0.132872113827048 0.000101143487310671 NA NA NA hsa-miR-335-5p SMAD3 -0.466533891325811 0.0676987038122831 -0.104935015261858 0.513761397736816 miRNAWalker2_validate -0.113837951066797 0.000426295808318841 NA NA NA hsa-miR-146b-5p SMAD4 1.0922867893808 5.63754607494775e-06 -0.515653744933977 9.47137433628545e-06 PITA;miRanda;miRNATAP -0.109392210828109 6.88759131517055e-07 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-155-5p SMAD4 0.813513839059142 0.000608282725633232 -0.515653744933977 9.47137433628545e-06 miRNAWalker2_validate -0.11758126013491 1.55919717084934e-07 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-199a-5p SMAD4 1.3057193856884 2.38429382751645e-08 -0.515653744933977 9.47137433628545e-06 miRNAWalker2_validate;miRTarBase;miRanda -0.118493107916432 1.4071018929418e-07 NA NA NA hsa-miR-214-5p SMAD4 0.722336234279023 0.00539148054719041 -0.515653744933977 9.47137433628545e-06 MirTarget -0.114669708727048 2.13522290338095e-08 NA NA NA hsa-miR-27a-3p SMAD4 0.433402568013802 0.00737164631768323 -0.515653744933977 9.47137433628545e-06 MirTarget -0.144020279947672 1.5900674575152e-05 NA NA NA hsa-miR-28-5p SMAD4 1.19639196514745 4.59365801666536e-18 -0.515653744933977 9.47137433628545e-06 miRanda;miRNATAP -0.110138329815836 0.00382181011203322 NA NA NA hsa-miR-34a-5p SMAD4 1.40588612517769 8.60097477768592e-12 -0.515653744933977 9.47137433628545e-06 miRNATAP -0.1876322269981 6.61051288734246e-14 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-361-5p SMAD4 0.21454431962475 0.0800957579368424 -0.515653744933977 9.47137433628545e-06 mirMAP -0.157388316044875 0.000434500601175461 NA NA NA hsa-miR-450b-5p SMAD4 1.69248953402469 1.96052058003353e-07 -0.515653744933977 9.47137433628545e-06 mirMAP -0.125104732481319 2.70976048720848e-12 NA NA NA hsa-miR-454-3p SMAD4 1.49453641052169 4.46235742871434e-09 -0.515653744933977 9.47137433628545e-06 miRNAWalker2_validate;miRNATAP -0.103755273712557 2.90984012875118e-05 NA NA NA hsa-miR-590-5p SMAD4 2.07441240363458 4.95240551694843e-14 -0.515653744933977 9.47137433628545e-06 miRanda -0.127332971579553 5.14267821558811e-08 NA NA NA hsa-let-7g-5p SMC1A 0.0837630831079359 0.583083118232597 0.117159288803223 0.394029699410641 MirTarget -0.162857290896637 9.38270439498395e-05 NA NA NA hsa-let-7i-5p SMC1A 0.605080599172936 1.48406814653206e-06 0.117159288803223 0.394029699410641 MirTarget -0.160832421968865 0.00144633843227071 NA NA NA hsa-miR-145-5p SMC1A -1.34926078156437 2.63526538800669e-07 0.117159288803223 0.394029699410641 mirMAP -0.110816797732075 2.68568886578013e-06 NA NA NA hsa-miR-181a-5p SMC1A -0.375429731222937 0.0562142867129802 0.117159288803223 0.394029699410641 mirMAP -0.128237994898768 6.43748873197714e-05 NA NA NA hsa-miR-181c-5p SMC1A 0.529875814537156 0.0125885822998008 0.117159288803223 0.394029699410641 mirMAP -0.104911926565205 0.000409514651132383 NA NA NA hsa-miR-195-3p SMC1A -1.33068822339418 6.65427393047357e-09 0.117159288803223 0.394029699410641 mirMAP -0.134861458843368 5.63796188614892e-07 NA NA NA hsa-miR-218-5p SMC1A -0.281408491748349 0.259553612322657 0.117159288803223 0.394029699410641 mirMAP -0.12446843089083 1.38501734572452e-06 NA NA NA hsa-miR-664a-3p SMC1A 0.443077463053857 0.0214248925850984 0.117159288803223 0.394029699410641 mirMAP -0.165304778544944 3.87774668030494e-07 NA NA NA hsa-miR-139-5p SMC3 -2.26625553116965 7.22375119369519e-16 0.14776244002586 0.262090726417497 miRanda -0.149456853999241 1.95950090396134e-13 NA NA NA hsa-miR-150-5p SMC3 -0.702328520623782 0.0215316651134431 0.14776244002586 0.262090726417497 MirTarget -0.107368671825811 3.79314149752003e-08 NA NA NA hsa-miR-181a-5p STAG1 -0.375429731222937 0.0562142867129802 -0.347223353596515 0.0124519840354079 miRNATAP -0.156661209374756 1.33730056020797e-06 NA NA NA hsa-miR-181b-5p STAG1 0.668793269169928 0.000239998092406404 -0.347223353596515 0.0124519840354079 miRNATAP -0.156549962903885 7.36492949054192e-06 NA NA NA hsa-miR-199a-5p STAG1 1.3057193856884 2.38429382751645e-08 -0.347223353596515 0.0124519840354079 miRanda -0.133033176901289 6.58795234082397e-07 NA NA NA hsa-miR-199b-5p STAG1 2.13822205171062 4.56262988762436e-15 -0.347223353596515 0.0124519840354079 miRanda -0.111612740062169 7.38371426585071e-07 NA NA NA hsa-miR-26b-5p STAG1 0.72362441215247 4.7794659748036e-05 -0.347223353596515 0.0124519840354079 miRNAWalker2_validate -0.171384745483632 1.51388599973053e-06 NA NA NA hsa-miR-27b-3p STAG1 0.236438984240408 0.12263510345883 -0.347223353596515 0.0124519840354079 MirTarget;miRNATAP -0.172263212541953 4.1638085543564e-05 NA NA NA hsa-miR-30b-5p STAG1 0.358144314839612 0.138026229059594 -0.347223353596515 0.0124519840354079 MirTarget -0.186826567748092 5.83550048673302e-13 NA NA NA hsa-miR-30c-5p STAG1 -0.327319105755825 0.123595832152687 -0.347223353596515 0.0124519840354079 MirTarget -0.193735922572635 6.42404973503114e-11 NA NA NA hsa-miR-30e-5p STAG1 1.60414100786743 3.78951090573667e-19 -0.347223353596515 0.0124519840354079 MirTarget -0.107850447788068 0.00172861203273019 NA NA NA hsa-miR-96-5p STAG1 3.0381097138467 4.40362891630201e-24 -0.347223353596515 0.0124519840354079 TargetScan;miRNATAP -0.120425152448354 1.91327023815061e-07 NA NA NA hsa-miR-186-5p STAG2 0.852175445703945 6.88885738584309e-10 -0.0269206181958239 0.79525001683633 miRNAWalker2_validate;MirTarget;mirMAP;miRNATAP -0.10790249996309 0.00158577632472914 NA NA NA hsa-miR-22-3p STAG2 1.42501909916631 1.72295005910055e-25 -0.0269206181958239 0.79525001683633 MirTarget;miRNATAP -0.208330562714551 2.01387914545125e-10 NA NA NA hsa-miR-29b-3p STAG2 3.10527711861309 3.01242507282711e-32 -0.0269206181958239 0.79525001683633 MirTarget;miRNATAP -0.103825731072492 3.64711781455807e-10 NA NA NA hsa-miR-30c-5p STAG2 -0.327319105755825 0.123595832152687 -0.0269206181958239 0.79525001683633 MirTarget;mirMAP;miRNATAP -0.137758709642032 4.15785228769962e-10 NA NA NA hsa-miR-342-3p STAG2 -0.128691966564961 0.561034080130801 -0.0269206181958239 0.79525001683633 miRanda -0.141667184061497 1.94843161514784e-11 NA NA NA hsa-miR-34a-5p STAG2 1.40588612517769 8.60097477768592e-12 -0.0269206181958239 0.79525001683633 miRNAWalker2_validate;miRNATAP -0.136905562720097 7.70527785889519e-10 NA NA NA hsa-miR-214-5p TFDP1 0.722336234279023 0.00539148054719041 0.373196320019367 0.0100794545466665 miRNATAP -0.100314525883581 8.84751621791122e-05 NA NA NA hsa-miR-30a-5p TFDP1 -0.924084264430689 0.000762030454634728 0.373196320019367 0.0100794545466665 MirTarget;miRNATAP -0.131662480170298 3.84343111619903e-08 NA NA NA hsa-miR-30b-5p TFDP1 0.358144314839612 0.138026229059594 0.373196320019367 0.0100794545466665 MirTarget -0.187560724224248 4.84447599077572e-12 NA NA NA hsa-miR-30c-5p TFDP1 -0.327319105755825 0.123595832152687 0.373196320019367 0.0100794545466665 MirTarget;miRNATAP -0.234431824915363 2.30795878151321e-14 NA NA NA hsa-miR-30d-3p TFDP1 0.00396376345349925 0.986457040013182 0.373196320019367 0.0100794545466665 MirTarget;miRNATAP -0.144261843947791 6.44278505088875e-06 NA NA NA hsa-miR-30d-5p TFDP1 -0.920901858717441 3.50898334321668e-05 0.373196320019367 0.0100794545466665 MirTarget;miRNATAP -0.184548680992811 3.32793788255031e-10 NA NA NA hsa-miR-374a-5p TFDP1 -0.197027254874826 0.298080902192861 0.373196320019367 0.0100794545466665 MirTarget -0.107983828384979 0.00668381847250603 NA NA NA hsa-let-7b-3p TFDP2 -1.81889978084306 6.9913416210266e-19 0.519679209419981 0.0011095172022417 mirMAP -0.177509792539564 2.25651062601767e-07 NA NA NA hsa-miR-101-5p TFDP2 -0.0265235292039296 0.917878791358577 0.519679209419981 0.0011095172022417 mirMAP -0.102658058410615 0.00404287159192473 NA NA NA hsa-miR-125a-5p TFDP2 -1.04824536696301 3.97386082850476e-07 0.519679209419981 0.0011095172022417 mirMAP -0.171357414393792 9.80558928937909e-07 NA NA NA hsa-miR-125b-5p TFDP2 -0.548859243919575 0.0107224406584463 0.519679209419981 0.0011095172022417 mirMAP -0.164747060089267 1.24212574733174e-06 NA NA NA hsa-miR-195-3p TFDP2 -1.33068822339418 6.65427393047357e-09 0.519679209419981 0.0011095172022417 mirMAP -0.16286576476624 2.16292356309204e-07 NA NA NA hsa-miR-195-5p TFDP2 -1.01577502605386 4.80814718341729e-05 0.519679209419981 0.0011095172022417 MirTarget;mirMAP -0.131723197336252 1.78569498738855e-05 NA NA NA hsa-miR-23a-3p TFDP2 0.111958289789488 0.393086414480463 0.519679209419981 0.0011095172022417 mirMAP -0.214599095453736 0.000164571263397484 NA NA NA hsa-miR-23b-3p TFDP2 -0.070273068040148 0.620585267977425 0.519679209419981 0.0011095172022417 mirMAP -0.146420372741244 0.00539581655534505 NA NA NA hsa-miR-27a-3p TFDP2 0.433402568013802 0.00737164631768323 0.519679209419981 0.0011095172022417 mirMAP -0.119013123500366 0.0094356043996962 NA NA NA hsa-miR-29a-3p TFDP2 0.101650412194573 0.573201097011668 0.519679209419981 0.0011095172022417 mirMAP -0.153818623310826 0.000174165821937716 NA NA NA hsa-miR-3065-3p TFDP2 0.381740717819351 0.30795546546997 0.519679209419981 0.0011095172022417 MirTarget -0.103913879110609 8.78983387603375e-08 NA NA NA hsa-miR-320a TFDP2 -0.961144925954715 1.62478794429204e-08 0.519679209419981 0.0011095172022417 mirMAP -0.133646650088158 0.00182554146850289 NA NA NA hsa-miR-34a-5p TFDP2 1.40588612517769 8.60097477768592e-12 0.519679209419981 0.0011095172022417 miRNATAP -0.114712339862118 0.00105006012105065 NA NA NA hsa-miR-497-5p TFDP2 -0.0546347378264729 0.786205564901684 0.519679209419981 0.0011095172022417 MirTarget;mirMAP -0.220448817086876 1.11603733988533e-09 NA NA NA hsa-miR-107 TGFB2 0.658676029898313 5.11480446318819e-07 -1.54728695593794 7.69099073313309e-06 miRanda -0.355503342954706 0.0038910869011085 NA NA NA hsa-miR-141-3p TGFB2 3.36993755486106 5.42939251147195e-32 -1.54728695593794 7.69099073313309e-06 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.398731446418857 4.7542493450425e-15 NA NA NA hsa-miR-142-3p TGFB2 3.98476449801341 1.56256182021111e-35 -1.54728695593794 7.69099073313309e-06 miRNATAP -0.187445508387807 4.91415161970629e-05 NA NA NA hsa-miR-148a-3p TGFB2 2.30885799126944 1.95226081368985e-21 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.318993015839907 3.72194712163796e-07 NA NA NA hsa-miR-148b-3p TGFB2 0.483970528590224 0.0026495409465901 -1.54728695593794 7.69099073313309e-06 MirTarget -0.597854798049066 1.54973691719479e-09 NA NA NA hsa-miR-186-5p TGFB2 0.852175445703945 6.88885738584309e-10 -1.54728695593794 7.69099073313309e-06 mirMAP -0.409008453141581 0.000403399259315524 NA NA NA hsa-miR-193b-3p TGFB2 1.10444771306846 0.000822888533401377 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.171701127106121 0.000381178774316089 NA NA NA hsa-miR-200a-3p TGFB2 3.14766878548496 1.32850889777422e-21 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.154438122204007 0.00120018739162872 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 1.06866854356847 0.00389979689199624 -1.54728695593794 7.69099073313309e-06 MirTarget -0.12742735196134 0.0031970050420777 NA NA NA hsa-miR-21-5p TGFB2 4.38165933891779 1.52536633902505e-92 -1.54728695593794 7.69099073313309e-06 miRNAWalker2_validate -0.232847735640903 0.000134967329541337 NA NA NA hsa-miR-29b-3p TGFB2 3.10527711861309 3.01242507282711e-32 -1.54728695593794 7.69099073313309e-06 miRTarBase;MirTarget;miRNATAP -0.323475743722128 9.24598069519868e-09 NA NA NA hsa-miR-301a-3p TGFB2 2.70198002906399 1.56420889710984e-14 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.16074364225942 0.003487243350105 NA NA NA hsa-miR-324-5p TGFB2 1.06955541886548 5.39722006604758e-05 -1.54728695593794 7.69099073313309e-06 miRanda -0.277999824516596 3.4653275853172e-06 NA NA NA hsa-miR-330-5p TGFB2 0.168520831101569 0.336433937906706 -1.54728695593794 7.69099073313309e-06 miRanda -0.295257890261626 0.00139702498209663 NA NA NA hsa-miR-335-3p TGFB2 1.51116383169018 6.88553098788624e-13 -1.54728695593794 7.69099073313309e-06 mirMAP -0.356021240436402 1.58351764723679e-06 NA NA NA hsa-miR-375 TGFB2 0.615547997686534 0.149199273675144 -1.54728695593794 7.69099073313309e-06 miRNAWalker2_validate -0.199582093308253 8.10520720431323e-08 NA NA NA hsa-miR-454-3p TGFB2 1.49453641052169 4.46235742871434e-09 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.278722444132023 0.000172215670429774 NA NA NA hsa-miR-589-3p TGFB2 1.34253876396688 1.84935927493927e-05 -1.54728695593794 7.69099073313309e-06 MirTarget -0.136277206270106 0.00952077915925194 NA NA NA hsa-miR-590-3p TGFB2 0.83851360565783 0.00129224433453587 -1.54728695593794 7.69099073313309e-06 mirMAP -0.246860466689251 0.000814615379526392 NA NA NA hsa-miR-590-5p TGFB2 2.07441240363458 4.95240551694843e-14 -1.54728695593794 7.69099073313309e-06 miRanda;miRNATAP -0.326100319483825 3.24920581765168e-06 NA NA NA hsa-miR-151a-5p TGFB3 1.23124135275661 2.93488020257558e-12 -0.422252931437748 0.0394980941232173 MirTarget -0.160744804451189 0.00224479945628548 NA NA NA hsa-miR-139-5p TTK -2.26625553116965 7.22375119369519e-16 3.26207263279613 3.47557026804114e-19 miRanda -0.506168249726818 3.12678480363878e-18 NA NA NA hsa-miR-338-5p TTK -1.83316380675941 4.03269924759167e-07 3.26207263279613 3.47557026804114e-19 PITA -0.367154806501806 2.26832657875078e-15 NA NA NA hsa-miR-140-3p WEE1 -1.11373309124537 8.35257079443689e-14 0.550261957085168 0.0010270063275243 PITA;miRNATAP -0.20739187249486 4.44658394976086e-05 NA NA NA hsa-miR-146b-5p YWHAE 1.0922867893808 5.63754607494775e-06 -0.162345608104685 0.146274876044794 miRanda -0.111814411639533 8.76763789112146e-08 NA NA NA hsa-miR-155-5p YWHAE 0.813513839059142 0.000608282725633232 -0.162345608104685 0.146274876044794 MirTarget;miRNATAP -0.123012732065191 6.9279077580742e-09 NA NA NA hsa-miR-199a-5p YWHAE 1.3057193856884 2.38429382751645e-08 -0.162345608104685 0.146274876044794 miRanda -0.148964380915099 1.85988470639596e-12 NA NA NA hsa-miR-199b-5p YWHAE 2.13822205171062 4.56262988762436e-15 -0.162345608104685 0.146274876044794 miRanda -0.120520769429681 1.48491231495563e-11 NA NA NA hsa-miR-139-5p YWHAG -2.26625553116965 7.22375119369519e-16 0.440821980058659 0.00101832071918287 MirTarget;PITA;miRanda;miRNATAP -0.127495400492206 1.2727841918362e-09 NA NA NA hsa-miR-140-3p YWHAG -1.11373309124537 8.35257079443689e-14 0.440821980058659 0.00101832071918287 MirTarget;PITA;miRNATAP -0.306652373379445 1.11890284888968e-14 NA NA NA hsa-miR-181a-5p YWHAG -0.375429731222937 0.0562142867129802 0.440821980058659 0.00101832071918287 MirTarget;miRNATAP -0.173505222876932 2.79310441800563e-08 NA NA NA hsa-miR-181c-5p YWHAG 0.529875814537156 0.0125885822998008 0.440821980058659 0.00101832071918287 MirTarget;miRNATAP -0.170024749920434 3.49311586517858e-09 NA NA NA hsa-miR-200a-3p YWHAG 3.14766878548496 1.32850889777422e-21 0.440821980058659 0.00101832071918287 MirTarget;miRNATAP -0.112404756335661 5.04076550847479e-10 NA NA NA hsa-miR-200b-3p YWHAG 1.55157578247391 4.83790020897188e-09 0.440821980058659 0.00101832071918287 MirTarget;TargetScan -0.13160534442703 6.40730407184039e-09 NA NA NA hsa-miR-30a-5p YWHAG -0.924084264430689 0.000762030454634728 0.440821980058659 0.00101832071918287 miRNATAP -0.201085222503192 1.00065004288776e-20 NA NA NA hsa-miR-30b-5p YWHAG 0.358144314839612 0.138026229059594 0.440821980058659 0.00101832071918287 miRNATAP -0.181888404617956 4.18015678029477e-13 NA NA NA hsa-miR-30c-5p YWHAG -0.327319105755825 0.123595832152687 0.440821980058659 0.00101832071918287 miRNATAP -0.253949498332365 1.69959478903248e-19 NA NA NA hsa-miR-30d-5p YWHAG -0.920901858717441 3.50898334321668e-05 0.440821980058659 0.00101832071918287 miRNATAP -0.235001527999773 1.27841332129965e-18 NA NA NA hsa-miR-30e-5p YWHAG 1.60414100786743 3.78951090573667e-19 0.440821980058659 0.00101832071918287 miRNATAP -0.166831106737098 4.41822966338321e-07 NA NA NA hsa-miR-320a YWHAG -0.961144925954715 1.62478794429204e-08 0.440821980058659 0.00101832071918287 PITA;miRanda;miRNATAP -0.138044013407694 0.000124028645415388 NA NA NA hsa-miR-342-3p YWHAG -0.128691966564961 0.561034080130801 0.440821980058659 0.00101832071918287 miRanda -0.112708260763668 5.54327050620456e-05 NA NA NA hsa-miR-361-3p YWHAG 0.0988926195529967 0.549128728500555 0.440821980058659 0.00101832071918287 miRNATAP -0.180828220753678 1.49095137215055e-06 NA NA NA hsa-miR-500a-5p YWHAG 0.648155655714409 0.0104657432932038 0.440821980058659 0.00101832071918287 MirTarget;miRNATAP -0.116956873840769 2.67083784348092e-06 NA NA NA hsa-miR-103a-3p YWHAH 0.538497806383155 1.88134691850591e-05 -0.232507548831896 0.0270772293659851 miRNAWalker2_validate;MirTarget;miRNATAP -0.203453716772227 1.0945341693782e-07 NA NA NA hsa-miR-107 YWHAH 0.658676029898313 5.11480446318819e-07 -0.232507548831896 0.0270772293659851 MirTarget;PITA;miRanda;miRNATAP -0.11083014392296 0.00269449165913979 NA NA NA hsa-miR-186-5p YWHAH 0.852175445703945 6.88885738584309e-10 -0.232507548831896 0.0270772293659851 miRNAWalker2_validate -0.195720652925808 1.17969368044911e-08 NA NA NA hsa-miR-324-5p YWHAH 1.06955541886548 5.39722006604758e-05 -0.232507548831896 0.0270772293659851 miRNAWalker2_validate -0.1101263094924 6.33335452195712e-10 NA NA NA hsa-miR-139-5p YWHAQ -2.26625553116965 7.22375119369519e-16 0.167770822857293 0.149541644649826 MirTarget;PITA;miRanda;miRNATAP -0.125565430539164 3.05602665873019e-12 NA NA NA hsa-miR-145-3p YWHAQ -0.68545633476888 0.000680820366475469 0.167770822857293 0.149541644649826 MirTarget;miRNATAP -0.172660588094719 2.86041381730263e-11 NA NA NA hsa-miR-15a-5p YWHAQ 1.62575353599172 1.55312121019827e-19 0.167770822857293 0.149541644649826 MirTarget;miRNATAP -0.103636165558495 0.000288131949373333 NA NA NA hsa-miR-200b-3p YWHAQ 1.55157578247391 4.83790020897188e-09 0.167770822857293 0.149541644649826 TargetScan -0.103114978597469 1.46440567065747e-07 NA NA NA hsa-miR-27a-3p YWHAQ 0.433402568013802 0.00737164631768323 0.167770822857293 0.149541644649826 MirTarget -0.114218331322201 0.000575063051743503 NA NA NA hsa-miR-27b-3p YWHAQ 0.236438984240408 0.12263510345883 0.167770822857293 0.149541644649826 MirTarget -0.127095716424262 0.000300405629060681 NA NA NA hsa-miR-320a YWHAQ -0.961144925954715 1.62478794429204e-08 0.167770822857293 0.149541644649826 MirTarget;PITA;miRanda;miRNATAP -0.170752732171646 2.8347653578931e-08 NA NA NA hsa-miR-497-5p YWHAQ -0.0546347378264729 0.786205564901684 0.167770822857293 0.149541644649826 MirTarget;miRNATAP -0.243634757664687 1.35163778783183e-21 NA NA NA hsa-let-7b-5p YWHAZ -1.62016148171663 1.56547487335694e-15 0.742048268483137 1.17639688533012e-07 miRNAWalker2_validate -0.16430584605795 1.03419318175904e-07 NA NA NA hsa-miR-125a-5p YWHAZ -1.04824536696301 3.97386082850476e-07 0.742048268483137 1.17639688533012e-07 miRanda -0.237020763887747 6.87766229457755e-15 NA NA NA hsa-miR-140-3p YWHAZ -1.11373309124537 8.35257079443689e-14 0.742048268483137 1.17639688533012e-07 MirTarget;PITA;miRNATAP -0.391596646798971 1.8940405019791e-21 NA NA NA hsa-miR-186-5p YWHAZ 0.852175445703945 6.88885738584309e-10 0.742048268483137 1.17639688533012e-07 mirMAP -0.152208595579121 0.00118572329862627 NA NA NA hsa-miR-195-3p YWHAZ -1.33068822339418 6.65427393047357e-09 0.742048268483137 1.17639688533012e-07 MirTarget -0.222495897728137 3.41482438203482e-16 NA NA NA hsa-miR-30a-5p YWHAZ -0.924084264430689 0.000762030454634728 0.742048268483137 1.17639688533012e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.201186598647973 1.15722338635181e-18 NA NA NA hsa-miR-30c-5p YWHAZ -0.327319105755825 0.123595832152687 0.742048268483137 1.17639688533012e-07 MirTarget;miRNATAP -0.288739774257498 9.48887811222695e-23 24519092 Involvement of miR 30c in resistance to doxorubicin by regulating YWHAZ in breast cancer cells; Together our findings provided evidence that miR-30c was one of the important miRNAs in doxorubicin resistance by regulating YWHAZ in the breast cancer cell line MCF-7/ADR drug resistance breast cancer hsa-miR-30d-5p YWHAZ -0.920901858717441 3.50898334321668e-05 0.742048268483137 1.17639688533012e-07 MirTarget;miRNATAP -0.141642518231123 9.75824254047956e-07 NA NA NA hsa-miR-30e-5p YWHAZ 1.60414100786743 3.78951090573667e-19 0.742048268483137 1.17639688533012e-07 MirTarget;miRNATAP -0.121458978508407 0.000533900032886707 NA NA NA hsa-miR-320a YWHAZ -0.961144925954715 1.62478794429204e-08 0.742048268483137 1.17639688533012e-07 MirTarget;PITA;miRanda;miRNATAP -0.157423933177928 3.20781580410077e-05 NA NA NA hsa-miR-328-3p YWHAZ -0.971820898675371 0.000667255504710486 0.742048268483137 1.17639688533012e-07 MirTarget -0.124104498406864 3.32290942379795e-08 NA NA NA hsa-miR-484 YWHAZ -0.228576985124486 0.244112867390855 0.742048268483137 1.17639688533012e-07 miRNAWalker2_validate -0.116171758391268 0.000497835813356803 NA NA NA hsa-miR-664a-3p YWHAZ 0.443077463053857 0.0214248925850984 0.742048268483137 1.17639688533012e-07 mirMAP -0.262638767629816 1.83967801674611e-15 NA NA NA