miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-106a-5p	TGFBR2	2.48882002962836	1.99757727374521e-12	-1.5612933795263	2.09571393414153e-11	miRTarBase;miRNATAP	-0.174237668172683	2.7024970040951e-08	22912877	MiR-106a inhibits the expression of transforming growth factor-β receptor 2 TGFBR2 leading to increased CRC cell migration and invasion	cell migration	colorectal cancer
hsa-miR-106b-5p	TGFBR2	2.46782146831112	1.36171495805632e-23	-1.5612933795263	2.09571393414153e-11	miRNATAP	-0.446340567749987	1.4640429348369e-26		NA	NA	NA
hsa-miR-107	TGFBR2	1.30977326593435	1.30372468603965e-11	-1.5612933795263	2.09571393414153e-11	miRanda;miRNATAP	-0.33082940368913	1.15759545655126e-08		NA	NA	NA
hsa-miR-130a-3p	TGFBR2	2.02021855058359	1.26427102520415e-11	-1.5612933795263	2.09571393414153e-11	miRNATAP	-0.187222356261558	5.74404160623046e-07		NA	NA	NA
hsa-miR-130b-3p	TGFBR2	3.5350292994509	1.73934183852569e-27	-1.5612933795263	2.09571393414153e-11	miRNAWalker2_validate;miRNATAP	-0.279678154840768	1.9762101701233e-18	25024357	Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC		lung squamous cell cancer
hsa-miR-17-5p	TGFBR2	3.2710598467455	9.93128340539455e-27	-1.5612933795263	2.09571393414153e-11	miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP	-0.302277707820119	6.79145607037112e-19	25011053;27120811	We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer	;	kidney renal cell cancer;gastric cancer
hsa-miR-186-5p	TGFBR2	1.47445398888668	3.0781726595413e-15	-1.5612933795263	2.09571393414153e-11	miRNATAP	-0.383453901935314	9.23917606419292e-11		NA	NA	NA
hsa-miR-18a-5p	TGFBR2	3.78535678765353	3.72446596213886e-26	-1.5612933795263	2.09571393414153e-11	miRNAWalker2_validate	-0.25381972833671	2.41323249210829e-16		NA	NA	NA
hsa-miR-19a-3p	TGFBR2	3.42309334186656	3.02671914353412e-28	-1.5612933795263	2.09571393414153e-11	miRNAWalker2_validate;miRNATAP	-0.277232207383645	1.48488496649533e-16		NA	NA	NA
hsa-miR-19b-3p	TGFBR2	2.49529833021187	1.57028265846699e-23	-1.5612933795263	2.09571393414153e-11	miRNAWalker2_validate;miRNATAP	-0.351923320676886	1.03809079896527e-16		NA	NA	NA
hsa-miR-20a-5p	TGFBR2	3.15577933619191	4.19753346442454e-25	-1.5612933795263	2.09571393414153e-11	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.29433840605417	1.11976352607645e-17		NA	NA	NA
hsa-miR-20b-5p	TGFBR2	2.07706563022469	1.10107236083433e-05	-1.5612933795263	2.09571393414153e-11	miRNATAP	-0.105991731825053	9.98951097559816e-06		NA	NA	NA
hsa-miR-21-5p	TGFBR2	2.73773305747971	1.38864982139576e-43	-1.5612933795263	2.09571393414153e-11	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.1959869038848	0.000202473977886908	24037531	Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway		prostate cancer
hsa-miR-29b-2-5p	TGFBR2	0.910668640983475	0.00666655585493488	-1.5612933795263	2.09571393414153e-11	mirMAP	-0.106614907621936	0.00190433915326164		NA	NA	NA
hsa-miR-301a-3p	TGFBR2	2.81024345929638	2.29784847962242e-17	-1.5612933795263	2.09571393414153e-11	miRNATAP	-0.303245579782603	4.36341401740489e-19	25551793	MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2		colorectal cancer
hsa-miR-320a	TGFBR2	0.438165828017084	0.0390159073347133	-1.5612933795263	2.09571393414153e-11	miRanda;miRNATAP	-0.147256255771787	0.0072521693939925		NA	NA	NA
hsa-miR-320b	TGFBR2	1.55692969039548	1.41071034251915e-08	-1.5612933795263	2.09571393414153e-11	miRanda;miRNATAP	-0.259785049714809	1.72104577406335e-10		NA	NA	NA
hsa-miR-335-3p	TGFBR2	3.08791651139852	5.31309869723517e-12	-1.5612933795263	2.09571393414153e-11	mirMAP	-0.116451466105744	2.86501897855708e-06		NA	NA	NA
hsa-miR-335-5p	TGFBR2	1.77247705492746	2.22457658872091e-06	-1.5612933795263	2.09571393414153e-11	miRNAWalker2_validate	-0.108328975461909	0.000362366652132911		NA	NA	NA
hsa-miR-33a-3p	TGFBR2	1.72765312072219	1.51784443453521e-07	-1.5612933795263	2.09571393414153e-11	mirMAP	-0.218324746449326	5.80693592871469e-09		NA	NA	NA
hsa-miR-429	TGFBR2	4.48815175680773	2.44117492218206e-17	-1.5612933795263	2.09571393414153e-11	miRNATAP	-0.182453703283022	7.13137317316041e-20		NA	NA	NA
hsa-miR-454-3p	TGFBR2	2.47234127820054	1.12878018736016e-21	-1.5612933795263	2.09571393414153e-11	miRNATAP	-0.334757039971147	2.96928366293251e-15		NA	NA	NA
hsa-miR-501-3p	TGFBR2	1.83132758513743	1.10971547702065e-10	-1.5612933795263	2.09571393414153e-11	TargetScan	-0.239042838968307	1.06476001924321e-09		NA	NA	NA
hsa-miR-508-3p	TGFBR2	1.05493034310846	0.0393857095042515	-1.5612933795263	2.09571393414153e-11	miRNATAP	-0.119214194503115	1.55583026735658e-07		NA	NA	NA
hsa-miR-590-3p	TGFBR2	2.59289455139753	1.03200520972022e-21	-1.5612933795263	2.09571393414153e-11	miRanda	-0.298641027773627	2.0141780556407e-13		NA	NA	NA
hsa-miR-590-5p	TGFBR2	3.18300989862077	2.06813568597893e-26	-1.5612933795263	2.09571393414153e-11	miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP	-0.294796030766598	2.66958610835318e-16		NA	NA	NA
hsa-miR-9-5p	TGFBR2	1.02304182473283	0.042901377604859	-1.5612933795263	2.09571393414153e-11	miRNATAP	-0.120425377888386	8.76751437160767e-08	25024357	Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC		lung squamous cell cancer
hsa-miR-92a-3p	TGFBR2	2.06460102658973	1.44784291084757e-19	-1.5612933795263	2.09571393414153e-11	miRNAWalker2_validate	-0.402171657787311	8.61853387794715e-18		NA	NA	NA
hsa-miR-93-5p	TGFBR2	3.03961860136032	1.11672209617395e-24	-1.5612933795263	2.09571393414153e-11	miRNAWalker2_validate;miRNATAP	-0.345215781740609	4.92958365930485e-23		NA	NA	NA