miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7b-3p AKT2 0.239865279324672 0.00721479815526816 -0.340477996057433 3.62402949162022e-08 MirTarget -0.103250394013056 0.00819845290941259 NA NA NA hsa-miR-140-5p AKT2 0.504309496243674 3.09884038729031e-11 -0.340477996057433 3.62402949162022e-08 mirMAP -0.257894167615696 4.25294111137846e-09 NA NA NA hsa-miR-193a-3p AKT2 0.849206638484406 3.68101781083335e-14 -0.340477996057433 3.62402949162022e-08 miRanda -0.1602336102543 4.66296866332011e-08 NA NA NA hsa-miR-1976 AKT2 0.343475600930938 0.000360243844871748 -0.340477996057433 3.62402949162022e-08 miRNATAP -0.114100456416688 0.00148676672535644 NA NA NA hsa-miR-21-5p AKT2 2.51462371613332 3.30620591950316e-66 -0.340477996057433 3.62402949162022e-08 miRNAWalker2_validate -0.116002520060245 7.24256492760299e-10 NA NA NA hsa-miR-2355-5p AKT2 1.57515081110162 3.54962327490702e-48 -0.340477996057433 3.62402949162022e-08 mirMAP -0.158007486287123 5.63512797747714e-09 NA NA NA hsa-miR-24-3p AKT2 0.173813044685099 0.00565259443420961 -0.340477996057433 3.62402949162022e-08 mirMAP -0.145738275793208 0.0095430051404417 NA NA NA hsa-miR-330-5p AKT2 1.44960468659754 2.12131210588035e-45 -0.340477996057433 3.62402949162022e-08 miRanda -0.199850402161812 2.39463482226386e-12 NA NA NA hsa-miR-338-3p AKT2 0.906250377628867 2.76970900371139e-15 -0.340477996057433 3.62402949162022e-08 mirMAP -0.160942202850334 1.55482491354725e-08 NA NA NA hsa-miR-342-3p AKT2 1.4124432570595 1.07208971556131e-28 -0.340477996057433 3.62402949162022e-08 mirMAP -0.193694719446483 5.5338386148732e-16 NA NA NA hsa-miR-423-3p AKT2 0.460506077888547 3.44680149368459e-09 -0.340477996057433 3.62402949162022e-08 miRNAWalker2_validate -0.134093002116074 0.00224236224837297 NA NA NA hsa-miR-106b-5p AKT3 1.07509411417907 2.11739194181878e-36 -0.243988630870274 0.0117503955413685 miRNATAP -0.362551297020254 3.77551886386752e-11 NA NA NA hsa-miR-107 AKT3 0.140046250553248 0.0943611632552367 -0.243988630870274 0.0117503955413685 PITA;miRanda -0.284787420850406 8.53745778311515e-06 NA NA NA hsa-miR-146b-5p AKT3 1.40714170253819 2.9559871816487e-12 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate -0.106480044558668 2.77668665683102e-05 NA NA NA hsa-miR-15a-5p AKT3 1.42663930007845 1.36006952074963e-57 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate;miRTarBase;miRNATAP -0.209553352701426 2.74861510149098e-05 NA NA NA hsa-miR-15b-5p AKT3 0.773001494057531 1.71784656078957e-16 -0.243988630870274 0.0117503955413685 miRNATAP -0.179137071242714 0.00102312999530003 NA NA NA hsa-miR-16-5p AKT3 0.934012514027655 4.85417898318515e-24 -0.243988630870274 0.0117503955413685 miRNAWalker2_validate;miRTarBase;miRNATAP -0.174740148583929 0.00122158424330689 NA NA NA hsa-miR-17-3p AKT3 0.723795600017259 5.90151677164931e-18 -0.243988630870274 0.0117503955413685 miRNATAP -0.202376849787589 0.00088737719875351 NA NA NA hsa-miR-17-5p AKT3 0.494260110870015 3.8348005261e-09 -0.243988630870274 0.0117503955413685 TargetScan;miRNATAP -0.190824149294487 0.00237163147001594 NA NA NA hsa-miR-22-3p AKT3 0.198460552200729 0.00761005672059428 -0.243988630870274 0.0117503955413685 miRNATAP -0.407589872687642 1.12041867452881e-08 NA NA NA hsa-miR-29a-3p AKT3 -0.431613225927952 4.10166815070288e-08 -0.243988630870274 0.0117503955413685 miRNATAP -0.244491422189309 0.000269689815704259 NA NA NA hsa-miR-29b-3p AKT3 -0.228125979913806 0.0271621721891603 -0.243988630870274 0.0117503955413685 miRNATAP -0.247981734385757 1.40066355236384e-06 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-374b-5p AKT3 0.0804104684417872 0.365593963035077 -0.243988630870274 0.0117503955413685 mirMAP -0.250536892298211 3.33662467499594e-05 NA NA NA hsa-miR-421 AKT3 0.313155739887734 0.020433534776003 -0.243988630870274 0.0117503955413685 miRanda;mirMAP -0.144627984206661 0.000385343212972084 NA NA NA hsa-miR-542-3p AKT3 0.431147917094433 0.000254981247606435 -0.243988630870274 0.0117503955413685 miRanda -0.173551255334696 0.000111564350795738 NA NA NA hsa-miR-616-5p AKT3 0.913426384742148 3.78418389333709e-09 -0.243988630870274 0.0117503955413685 mirMAP -0.172749202880246 3.16635692442533e-07 NA NA NA hsa-miR-93-5p AKT3 1.37365940377595 2.37567548683245e-46 -0.243988630870274 0.0117503955413685 miRNATAP -0.172188027294336 0.000349761294454902 NA NA NA hsa-miR-590-3p BRAF 1.13702599385212 3.53435739887793e-22 -0.358904733193809 0.000122580700403634 miRanda -0.12838824199161 0.00196280318625335 NA NA NA hsa-let-7f-1-3p CAB39 0.477913872379336 4.46669616865068e-05 -0.830487046733484 1.29480496397313e-36 MirTarget -0.104795499663752 0.00491362578189965 NA NA NA hsa-miR-103a-3p CAB39 0.779373475434461 7.37867196796994e-20 -0.830487046733484 1.29480496397313e-36 MirTarget;miRNATAP -0.274821283057085 4.32793677594312e-10 NA NA NA hsa-miR-151a-3p CAB39 0.657909055193034 1.46651056355997e-25 -0.830487046733484 1.29480496397313e-36 MirTarget -0.410678260298416 2.76791696733751e-12 NA NA NA hsa-miR-155-5p CAB39 3.26274490570809 5.06841441826518e-51 -0.830487046733484 1.29480496397313e-36 miRNAWalker2_validate;MirTarget;miRNATAP -0.124554028457992 2.33509818348333e-16 NA NA NA hsa-miR-15a-5p CAB39 1.42663930007845 1.36006952074963e-57 -0.830487046733484 1.29480496397313e-36 miRNATAP -0.341202388302582 1.86911297884744e-21 NA NA NA hsa-miR-15b-5p CAB39 0.773001494057531 1.71784656078957e-16 -0.830487046733484 1.29480496397313e-36 miRNATAP -0.20216401602133 7.83944349587114e-07 NA NA NA hsa-miR-16-1-3p CAB39 1.51429140700091 3.17219833254498e-37 -0.830487046733484 1.29480496397313e-36 MirTarget -0.218084372538386 2.84029576583698e-13 NA NA NA hsa-miR-16-5p CAB39 0.934012514027655 4.85417898318515e-24 -0.830487046733484 1.29480496397313e-36 miRNATAP -0.208551028337805 2.558504564625e-07 NA NA NA hsa-miR-193a-3p CAB39 0.849206638484406 3.68101781083335e-14 -0.830487046733484 1.29480496397313e-36 MirTarget;miRanda -0.227089178841442 2.19833568055793e-11 NA NA NA hsa-miR-195-5p CAB39 0.346502644882604 0.0092562828415903 -0.830487046733484 1.29480496397313e-36 miRNAWalker2_validate;miRTarBase;miRNATAP -0.133336783033075 9.7815417893723e-06 NA NA NA hsa-miR-19a-3p CAB39 0.722913586880779 2.76301458932381e-10 -0.830487046733484 1.29480496397313e-36 MirTarget;miRNATAP -0.17601622049489 2.36640498323006e-07 NA NA NA hsa-miR-19b-3p CAB39 0.195940928879427 0.0300512922542325 -0.830487046733484 1.29480496397313e-36 MirTarget;miRNATAP -0.140466860718 0.00186678489596182 NA NA NA hsa-miR-223-3p CAB39 1.23291409735619 1.07767240442694e-17 -0.830487046733484 1.29480496397313e-36 MirTarget -0.157440206228478 1.79707262476988e-09 NA NA NA hsa-miR-23a-3p CAB39 0.761438723382355 4.09310879199257e-27 -0.830487046733484 1.29480496397313e-36 MirTarget;miRNATAP -0.342559303051223 4.88675987036649e-11 NA NA NA hsa-miR-27a-3p CAB39 0.558934437526245 1.44256383086177e-12 -0.830487046733484 1.29480496397313e-36 MirTarget;miRNATAP -0.317992103020478 7.43337558448137e-11 NA NA NA hsa-miR-320a CAB39 0.412740558379182 2.02929519701706e-05 -0.830487046733484 1.29480496397313e-36 MirTarget;PITA;miRanda;miRNATAP -0.16148724102195 9.72115335252891e-05 NA NA NA hsa-miR-338-3p CAB39 0.906250377628867 2.76970900371139e-15 -0.830487046733484 1.29480496397313e-36 miRanda -0.157374486105905 2.73637209963096e-06 NA NA NA hsa-miR-374a-5p CAB39 0.543061152108237 2.19403097299769e-14 -0.830487046733484 1.29480496397313e-36 mirMAP -0.206238353950935 0.000190081548798306 NA NA NA hsa-miR-374b-3p CAB39 0.611842481331529 3.85718194756943e-07 -0.830487046733484 1.29480496397313e-36 MirTarget -0.101263466271756 0.00316989559529234 NA NA NA hsa-miR-452-5p CAB39 2.05325688842141 2.82238393643084e-40 -0.830487046733484 1.29480496397313e-36 MirTarget -0.19545200955648 4.45302556710289e-19 NA NA NA hsa-miR-455-5p CAB39 0.773674551205946 2.12957541541474e-09 -0.830487046733484 1.29480496397313e-36 PITA;miRanda -0.19249553134172 1.20888334284564e-10 NA NA NA hsa-miR-590-3p CAB39 1.13702599385212 3.53435739887793e-22 -0.830487046733484 1.29480496397313e-36 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.206605117042131 6.0001303425758e-11 NA NA NA hsa-miR-155-5p CAB39L 3.26274490570809 5.06841441826518e-51 -1.78116326154126 2.26481786621099e-53 miRNAWalker2_validate -0.376277709111401 9.260168941318e-50 NA NA NA hsa-miR-192-3p CAB39L 0.156650099616707 0.483496040900362 -1.78116326154126 2.26481786621099e-53 mirMAP -0.164705871894028 9.47282077609254e-07 NA NA NA hsa-miR-192-5p CAB39L 0.442478872410106 0.0669238175123954 -1.78116326154126 2.26481786621099e-53 miRNAWalker2_validate -0.181738342547722 2.79484550712785e-09 NA NA NA hsa-miR-342-3p CAB39L 1.4124432570595 1.07208971556131e-28 -1.78116326154126 2.26481786621099e-53 miRanda -0.647823424910648 1.25912209246491e-41 NA NA NA hsa-miR-374a-3p CAB39L 1.13863935833993 2.79089304015401e-44 -1.78116326154126 2.26481786621099e-53 MirTarget -0.847045825471683 3.41568800047493e-30 NA NA NA hsa-miR-542-3p CAB39L 0.431147917094433 0.000254981247606435 -1.78116326154126 2.26481786621099e-53 miRanda -0.253325235023802 6.50455603482671e-05 NA NA NA hsa-miR-590-3p CAB39L 1.13702599385212 3.53435739887793e-22 -1.78116326154126 2.26481786621099e-53 miRanda -0.572114918775335 2.71797284665126e-24 NA NA NA hsa-miR-590-5p CAB39L 0.709763558412506 1.11883921359361e-11 -1.78116326154126 2.26481786621099e-53 miRanda -0.521018968285434 1.34386049182327e-14 NA NA NA hsa-miR-7-1-3p CAB39L 0.544601828025304 5.33830451326047e-07 -1.78116326154126 2.26481786621099e-53 mirMAP -0.370175435674867 4.31590183973671e-08 NA NA NA hsa-miR-139-5p DDIT4 -0.704802495091118 2.36904108453776e-06 2.16368662998061 1.54601166495436e-45 MirTarget;miRanda;miRNATAP -0.212811288105503 0.000902260884977072 NA NA NA hsa-miR-199a-3p DDIT4 -1.61607426368083 1.97964980193147e-26 2.16368662998061 1.54601166495436e-45 MirTarget;PITA;miRNATAP -0.337054174457861 5.83494287354051e-09 NA NA NA hsa-miR-199b-3p DDIT4 -1.61804389801139 1.97668652730486e-26 2.16368662998061 1.54601166495436e-45 MirTarget;PITA;miRNATAP -0.336916890699972 5.66409102514339e-09 NA NA NA hsa-miR-200b-3p DDIT4 -1.70383252137161 2.38979336321755e-30 2.16368662998061 1.54601166495436e-45 TargetScan -0.476340538893359 4.84816173724126e-17 NA NA NA hsa-miR-30a-5p DDIT4 -0.778411951775343 2.73322451127932e-16 2.16368662998061 1.54601166495436e-45 MirTarget;miRNATAP -0.874614457328679 2.64517397122604e-21 NA NA NA hsa-miR-30b-5p DDIT4 -1.18330589477119 6.8341618466966e-27 2.16368662998061 1.54601166495436e-45 MirTarget -0.68641210192901 6.65570416737091e-19 NA NA NA hsa-miR-30c-5p DDIT4 -1.08783070774238 2.02505402525786e-24 2.16368662998061 1.54601166495436e-45 MirTarget;miRNATAP -0.747016684812148 1.0629513734135e-20 NA NA NA hsa-miR-30d-5p DDIT4 -0.202727675788184 0.00659067084745794 2.16368662998061 1.54601166495436e-45 MirTarget;miRNATAP -0.606513462309504 3.34569724594775e-06 NA NA NA hsa-miR-30e-5p DDIT4 -0.0905907245198101 0.21196704484334 2.16368662998061 1.54601166495436e-45 MirTarget -0.611793244511632 5.86163301562435e-06 NA NA NA hsa-miR-429 DDIT4 -2.16569233119434 2.66862243626443e-37 2.16368662998061 1.54601166495436e-45 miRanda;miRNATAP -0.440511070839646 5.89408931873978e-20 NA NA NA hsa-miR-615-3p DDIT4 -0.777370544471479 2.08193713560545e-08 2.16368662998061 1.54601166495436e-45 miRNAWalker2_validate -0.196993602165312 0.00417018557659908 NA NA NA hsa-miR-107 EIF4B 0.140046250553248 0.0943611632552367 0.265754888221512 0.000370911774075073 MirTarget;PITA;miRanda;miRNATAP -0.14866857828035 0.00288697258013526 NA NA NA hsa-miR-193b-3p EIF4B -0.273325765316079 0.104328826585392 0.265754888221512 0.000370911774075073 miRNAWalker2_validate -0.136557854642932 1.52060087619542e-08 NA NA NA hsa-miR-362-3p EIF4B -0.753214251798232 3.0025661608035e-07 0.265754888221512 0.000370911774075073 miRanda -0.163643050529037 4.95060472748533e-09 NA NA NA hsa-miR-429 EIF4B -2.16569233119434 2.66862243626443e-37 0.265754888221512 0.000370911774075073 miRanda;miRNATAP -0.102106541707063 1.88308160319094e-06 NA NA NA hsa-miR-532-3p EIF4B -1.759223962964 7.9077916669414e-40 0.265754888221512 0.000370911774075073 miRNATAP -0.134641880766081 6.6316836635778e-07 NA NA NA hsa-miR-126-5p EIF4E 0.785607261431085 5.77058629454465e-13 -0.592879162769574 2.23429360171169e-21 mirMAP -0.114986360293591 0.00038593683116203 NA NA NA hsa-miR-130b-3p EIF4E 1.12788913578446 2.939369462276e-16 -0.592879162769574 2.23429360171169e-21 mirMAP -0.130010254109064 2.01796960128932e-07 NA NA NA hsa-miR-142-5p EIF4E 1.88417391525707 1.2096808039882e-27 -0.592879162769574 2.23429360171169e-21 mirMAP -0.111938152052401 4.09257842023961e-09 NA NA NA hsa-miR-155-5p EIF4E 3.26274490570809 5.06841441826518e-51 -0.592879162769574 2.23429360171169e-21 mirMAP -0.104934553217022 3.01434690576764e-14 NA NA NA hsa-miR-15b-3p EIF4E 1.49422666971434 5.44139893275088e-29 -0.592879162769574 2.23429360171169e-21 mirMAP -0.135490489574837 4.02015267504856e-08 NA NA NA hsa-miR-16-5p EIF4E 0.934012514027655 4.85417898318515e-24 -0.592879162769574 2.23429360171169e-21 miRNAWalker2_validate -0.158076464262536 1.72109439890791e-05 NA NA NA hsa-miR-17-5p EIF4E 0.494260110870015 3.8348005261e-09 -0.592879162769574 2.23429360171169e-21 TargetScan -0.115319011434752 0.00741006427249683 NA NA NA hsa-miR-186-5p EIF4E 0.507217561043443 9.04455748270995e-10 -0.592879162769574 2.23429360171169e-21 mirMAP -0.137758645095685 0.00152481785154887 NA NA NA hsa-miR-25-3p EIF4E 1.12016166564779 3.79069348635778e-48 -0.592879162769574 2.23429360171169e-21 mirMAP -0.290037744966355 3.98867157436052e-13 NA NA NA hsa-miR-28-3p EIF4E 1.01277915413238 1.8655970171461e-43 -0.592879162769574 2.23429360171169e-21 mirMAP -0.296755213866688 3.87555840248158e-12 NA NA NA hsa-miR-32-5p EIF4E 0.407826130035097 7.26884631998646e-06 -0.592879162769574 2.23429360171169e-21 mirMAP -0.125399937975617 0.00172975997413774 NA NA NA hsa-miR-320a EIF4E 0.412740558379182 2.02929519701706e-05 -0.592879162769574 2.23429360171169e-21 MirTarget;miRanda -0.140662497263495 0.000172851537500746 NA NA NA hsa-miR-338-3p EIF4E 0.906250377628867 2.76970900371139e-15 -0.592879162769574 2.23429360171169e-21 miRanda -0.100364539022003 0.00102659122467453 NA NA NA hsa-miR-340-3p EIF4E 0.916396642224413 1.53096840464699e-18 -0.592879162769574 2.23429360171169e-21 MirTarget -0.127397339965355 0.000128165195724909 NA NA NA hsa-miR-374a-3p EIF4E 1.13863935833993 2.79089304015401e-44 -0.592879162769574 2.23429360171169e-21 mirMAP -0.267327634367235 2.48263922300642e-12 NA NA NA hsa-miR-374a-5p EIF4E 0.543061152108237 2.19403097299769e-14 -0.592879162769574 2.23429360171169e-21 mirMAP -0.141913765427639 0.00465001877160016 NA NA NA hsa-miR-452-5p EIF4E 2.05325688842141 2.82238393643084e-40 -0.592879162769574 2.23429360171169e-21 mirMAP -0.11908864870098 5.96862385610994e-09 NA NA NA hsa-miR-576-5p EIF4E 1.06681109513983 5.69294424466526e-24 -0.592879162769574 2.23429360171169e-21 mirMAP -0.15850130232059 6.89734673484199e-07 NA NA NA hsa-miR-590-3p EIF4E 1.13702599385212 3.53435739887793e-22 -0.592879162769574 2.23429360171169e-21 miRanda;mirMAP -0.121009922785523 3.15347765276384e-05 NA NA NA hsa-miR-7-1-3p EIF4E 0.544601828025304 5.33830451326047e-07 -0.592879162769574 2.23429360171169e-21 MirTarget -0.122486342429634 0.000220649147997829 NA NA NA hsa-miR-769-5p EIF4E 0.376837385738096 4.45440414144944e-07 -0.592879162769574 2.23429360171169e-21 miRNAWalker2_validate -0.175959571774459 0.000303054662693615 NA NA NA hsa-miR-92b-3p EIF4E 0.418630595140165 6.50466149211154e-05 -0.592879162769574 2.23429360171169e-21 mirMAP -0.130569488601578 0.000161347956190744 NA NA NA hsa-miR-125a-5p EIF4EBP1 -0.561874059994802 7.3931856356891e-13 1.80123929586267 2.12304033084494e-30 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.693130609645124 2.50560481498786e-09 26646586 Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ovarian cancer hsa-miR-125b-5p EIF4EBP1 -0.825456421494266 2.13029877878434e-15 1.80123929586267 2.12304033084494e-30 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.328703334871537 0.000176754185174443 17891175;26646586 Using a bioinformatics approach we have identified additional potential mRNA targets of one of the miRNAs miR-125b that are upregulated in prostate cancer and confirmed increased expression of one of these targets EIF4EBP1 in prostate cancer tissues;Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ; prostate cancer;ovarian cancer hsa-miR-874-3p EIF4EBP1 -1.50243370621573 8.39418307315909e-25 1.80123929586267 2.12304033084494e-30 MirTarget -0.573633359130349 2.31880892116845e-24 NA NA NA hsa-let-7b-5p HIF1A 0.770868211539597 6.63408323707647e-21 -1.19346845817997 1.46852928699648e-26 miRNAWalker2_validate -0.345707536018806 6.21642077702106e-06 NA NA NA hsa-miR-106b-3p HIF1A 1.64501892208456 2.40716634096089e-61 -1.19346845817997 1.46852928699648e-26 miRNAWalker2_validate -0.373633038610271 4.96506211950937e-12 NA NA NA hsa-miR-106b-5p HIF1A 1.07509411417907 2.11739194181878e-36 -1.19346845817997 1.46852928699648e-26 MirTarget -0.562852246652963 6.43433833267277e-17 NA NA NA hsa-miR-107 HIF1A 0.140046250553248 0.0943611632552367 -1.19346845817997 1.46852928699648e-26 miRNAWalker2_validate;miRTarBase;miRanda -0.28137905839986 0.000482632513525514 NA NA NA hsa-miR-142-3p HIF1A 1.88928758773299 2.72985643829893e-22 -1.19346845817997 1.46852928699648e-26 miRanda -0.137286457590645 1.65006081590185e-05 NA NA NA hsa-miR-151a-3p HIF1A 0.657909055193034 1.46651056355997e-25 -1.19346845817997 1.46852928699648e-26 MirTarget -0.494380249926573 5.70179263023509e-07 NA NA NA hsa-miR-155-5p HIF1A 3.26274490570809 5.06841441826518e-51 -1.19346845817997 1.46852928699648e-26 MirTarget -0.188449358303046 9.63024266187069e-14 NA NA NA hsa-miR-15b-3p HIF1A 1.49422666971434 5.44139893275088e-29 -1.19346845817997 1.46852928699648e-26 MirTarget -0.257056261191358 1.1700412173445e-08 NA NA NA hsa-miR-16-2-3p HIF1A 1.3046118743965 4.17207934608428e-19 -1.19346845817997 1.46852928699648e-26 MirTarget;mirMAP -0.202441410630139 2.32404146266523e-06 NA NA NA hsa-miR-18a-5p HIF1A 0.936704393213466 1.05064580570579e-10 -1.19346845817997 1.46852928699648e-26 miRNAWalker2_validate;MirTarget -0.200754500895614 6.37890921847183e-06 25069832 Last clinically relevant correlations between miR-18a HIF1A hypoxia-responsive gene expression and distant metastasis-free survival DMFS were assessed using published expression array breast tumors data sets; We identified HIF1A as a direct target of miR-18a; Analysis of previously published data revealed that higher expression of HIF1A and a panel of hypoxic genes is associated with shorter DMFS interval in patients with basal-like breast tumors and that within this subtype miR-18a expression is inversely correlated with hypoxic gene expression; The results of this study reveal a novel role for miR-18a in targeting HIF1A and repressing metastasis of basal-like breast tumors metastasis;poor survival breast cancer hsa-miR-195-3p HIF1A 0.808592887366705 6.8151241038711e-09 -1.19346845817997 1.46852928699648e-26 MirTarget -0.197637955689275 2.59206311302759e-05 NA NA NA hsa-miR-20a-5p HIF1A 0.702602695798242 4.06372887613329e-13 -1.19346845817997 1.46852928699648e-26 miRNAWalker2_validate;miRTarBase;MirTarget -0.184956503089538 0.00581594684495853 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-28-5p HIF1A 0.461962042257226 3.32424690573327e-11 -1.19346845817997 1.46852928699648e-26 miRanda -0.418250787199436 8.35797806947177e-06 NA NA NA hsa-miR-320a HIF1A 0.412740558379182 2.02929519701706e-05 -1.19346845817997 1.46852928699648e-26 miRanda -0.181376767474453 0.00847086286961233 NA NA NA hsa-miR-330-3p HIF1A 0.912906550436308 3.35037014057665e-13 -1.19346845817997 1.46852928699648e-26 MirTarget;PITA -0.163892685183747 0.00184246784707 NA NA NA hsa-miR-338-3p HIF1A 0.906250377628867 2.76970900371139e-15 -1.19346845817997 1.46852928699648e-26 MirTarget;PITA;miRanda -0.333993324093047 1.10277889014778e-09 NA NA NA hsa-miR-338-5p HIF1A 0.628429807914222 1.27575140717947e-06 -1.19346845817997 1.46852928699648e-26 MirTarget;PITA;miRNATAP -0.227430256884085 9.84214984894812e-06 NA NA NA hsa-miR-542-3p HIF1A 0.431147917094433 0.000254981247606435 -1.19346845817997 1.46852928699648e-26 miRanda -0.164926043552646 0.00353757933625007 NA NA NA hsa-miR-590-3p HIF1A 1.13702599385212 3.53435739887793e-22 -1.19346845817997 1.46852928699648e-26 PITA;miRanda;mirMAP -0.277202144140444 1.49747969826866e-07 NA NA NA hsa-miR-93-5p HIF1A 1.37365940377595 2.37567548683245e-46 -1.19346845817997 1.46852928699648e-26 MirTarget -0.35858537760327 1.42372908242136e-09 NA NA NA hsa-let-7a-3p MAPK1 0.0677487960013088 0.460458477653989 0.0752350253994916 0.244227817396104 mirMAP -0.120937214673988 0.00189910022756462 NA NA NA hsa-miR-221-3p MAPK1 0.337895669520713 0.0136448974691037 0.0752350253994916 0.244227817396104 mirMAP -0.18533006750384 1.05774724669662e-13 NA NA NA hsa-miR-222-3p MAPK1 0.214811008033524 0.0965295551752457 0.0752350253994916 0.244227817396104 mirMAP -0.111381984547009 4.49766515770734e-05 NA NA NA hsa-miR-29a-3p MAPK1 -0.431613225927952 4.10166815070288e-08 0.0752350253994916 0.244227817396104 mirMAP -0.199785129647306 6.26938786529944e-06 NA NA NA hsa-miR-29c-3p MAPK1 -0.238671318446745 0.0141475322347596 0.0752350253994916 0.244227817396104 mirMAP -0.118476374132015 0.00117661250325827 NA NA NA hsa-miR-30b-5p MAPK1 -1.18330589477119 6.8341618466966e-27 0.0752350253994916 0.244227817396104 mirMAP -0.126400578163208 1.7728740776704e-05 NA NA NA hsa-miR-103a-3p PDPK1 0.779373475434461 7.37867196796994e-20 -0.510472322281575 1.42486443382158e-12 mirMAP -0.2175257694452 1.44786317870175e-06 NA NA NA hsa-miR-106b-5p PDPK1 1.07509411417907 2.11739194181878e-36 -0.510472322281575 1.42486443382158e-12 mirMAP -0.373775528284647 6.06427033576607e-20 NA NA NA hsa-miR-130b-5p PDPK1 0.92990617673277 3.75880436852717e-12 -0.510472322281575 1.42486443382158e-12 mirMAP -0.159801427785345 4.47085650105793e-08 NA NA NA hsa-miR-15a-5p PDPK1 1.42663930007845 1.36006952074963e-57 -0.510472322281575 1.42486443382158e-12 mirMAP -0.245722730963218 6.85341631070058e-11 NA NA NA hsa-miR-15b-5p PDPK1 0.773001494057531 1.71784656078957e-16 -0.510472322281575 1.42486443382158e-12 mirMAP -0.208820360940694 4.66456283570873e-07 NA NA NA hsa-miR-16-5p PDPK1 0.934012514027655 4.85417898318515e-24 -0.510472322281575 1.42486443382158e-12 mirMAP -0.178867552324022 1.44574835446988e-05 NA NA NA hsa-miR-17-5p PDPK1 0.494260110870015 3.8348005261e-09 -0.510472322281575 1.42486443382158e-12 miRNAWalker2_validate;mirMAP -0.188493522783968 8.61169959888075e-05 NA NA NA hsa-miR-185-5p PDPK1 1.05056378692621 1.31174187880682e-22 -0.510472322281575 1.42486443382158e-12 miRNAWalker2_validate -0.139764535618314 8.83463879935965e-05 NA NA NA hsa-miR-186-5p PDPK1 0.507217561043443 9.04455748270995e-10 -0.510472322281575 1.42486443382158e-12 mirMAP -0.182661949792262 0.000170813515132444 NA NA NA hsa-miR-195-5p PDPK1 0.346502644882604 0.0092562828415903 -0.510472322281575 1.42486443382158e-12 mirMAP -0.115115541560453 0.000175169862056641 NA NA NA hsa-miR-197-3p PDPK1 0.297760714271229 0.00102679606305048 -0.510472322281575 1.42486443382158e-12 mirMAP -0.151013671003568 0.000855286791616651 NA NA NA hsa-miR-20a-5p PDPK1 0.702602695798242 4.06372887613329e-13 -0.510472322281575 1.42486443382158e-12 mirMAP -0.152645012433526 0.000191506454719393 NA NA NA hsa-miR-22-5p PDPK1 -0.197038086012602 0.106234828461117 -0.510472322281575 1.42486443382158e-12 miRNATAP -0.109207513326609 0.00120206518580051 NA NA NA hsa-miR-2355-5p PDPK1 1.57515081110162 3.54962327490702e-48 -0.510472322281575 1.42486443382158e-12 mirMAP -0.172045618576272 9.87605041174559e-08 NA NA NA hsa-miR-24-3p PDPK1 0.173813044685099 0.00565259443420961 -0.510472322281575 1.42486443382158e-12 miRNAWalker2_validate -0.488231684917234 2.64170172150227e-14 NA NA NA hsa-miR-27a-3p PDPK1 0.558934437526245 1.44256383086177e-12 -0.510472322281575 1.42486443382158e-12 miRNATAP -0.354049703707722 5.69100253886832e-13 NA NA NA hsa-miR-28-5p PDPK1 0.461962042257226 3.32424690573327e-11 -0.510472322281575 1.42486443382158e-12 mirMAP -0.306922928697709 7.92063821346507e-08 NA NA NA hsa-miR-320a PDPK1 0.412740558379182 2.02929519701706e-05 -0.510472322281575 1.42486443382158e-12 miRanda -0.196344112191884 2.57519561738161e-06 NA NA NA hsa-miR-320b PDPK1 0.300497419754843 0.0245219177384172 -0.510472322281575 1.42486443382158e-12 miRanda -0.140727534920885 3.77176273785697e-06 NA NA NA hsa-miR-330-3p PDPK1 0.912906550436308 3.35037014057665e-13 -0.510472322281575 1.42486443382158e-12 mirMAP -0.160262123414231 5.00464356133853e-07 NA NA NA hsa-miR-330-5p PDPK1 1.44960468659754 2.12131210588035e-45 -0.510472322281575 1.42486443382158e-12 mirMAP -0.236462612335887 2.67486358986537e-12 NA NA NA hsa-miR-342-3p PDPK1 1.4124432570595 1.07208971556131e-28 -0.510472322281575 1.42486443382158e-12 mirMAP -0.194551040391011 1.38426500608919e-11 NA NA NA hsa-miR-374a-3p PDPK1 1.13863935833993 2.79089304015401e-44 -0.510472322281575 1.42486443382158e-12 mirMAP -0.183366708748884 2.89759767613272e-05 NA NA NA hsa-miR-423-5p PDPK1 0.250929012519631 0.00288495915028486 -0.510472322281575 1.42486443382158e-12 miRNAWalker2_validate -0.184849862683297 0.000153104377010708 NA NA NA hsa-miR-484 PDPK1 0.571987778099603 9.67278224458421e-10 -0.510472322281575 1.42486443382158e-12 mirMAP -0.182086606148251 2.06174614498475e-05 NA NA NA hsa-miR-497-5p PDPK1 0.227757383708836 0.0600073987853074 -0.510472322281575 1.42486443382158e-12 mirMAP -0.101451111078774 0.00283638206539402 NA NA NA hsa-miR-590-3p PDPK1 1.13702599385212 3.53435739887793e-22 -0.510472322281575 1.42486443382158e-12 miRanda;miRNATAP -0.180543665890065 2.20548520230667e-08 NA NA NA hsa-miR-590-5p PDPK1 0.709763558412506 1.11883921359361e-11 -0.510472322281575 1.42486443382158e-12 miRanda -0.198011019013869 1.45790485472605e-07 NA NA NA hsa-miR-93-5p PDPK1 1.37365940377595 2.37567548683245e-46 -0.510472322281575 1.42486443382158e-12 mirMAP -0.21235032268781 5.41769778680355e-09 NA NA NA hsa-miR-149-5p PGF -1.95790336710741 8.46371715052367e-27 3.69738936393984 3.63417715211415e-41 miRNATAP -0.434144787619864 4.54062927450752e-07 NA NA NA hsa-miR-199b-5p PGF -2.39483476763681 1.04659509514884e-17 3.69738936393984 3.63417715211415e-41 miRanda -0.224137431584973 0.000173766273357621 NA NA NA hsa-miR-335-5p PGF -2.09515619961552 1.03765771499548e-25 3.69738936393984 3.63417715211415e-41 miRNATAP -0.515140827192959 5.43702586061577e-11 NA NA NA hsa-miR-429 PGF -2.16569233119434 2.66862243626443e-37 3.69738936393984 3.63417715211415e-41 miRNATAP -0.773105088772864 1.94034273033144e-19 NA NA NA hsa-miR-766-3p PGF -0.230617949950715 0.0566289375252083 3.69738936393984 3.63417715211415e-41 MirTarget -0.376787325836558 0.00862438364612218 NA NA NA hsa-let-7f-1-3p PIK3CA 0.477913872379336 4.46669616865068e-05 -0.342309377518198 0.000115361959187206 mirMAP -0.117169302105272 0.00980511224865979 NA NA NA hsa-miR-148a-5p PIK3CA 0.415500302855613 0.000691460831436767 -0.342309377518198 0.000115361959187206 mirMAP -0.127137756769153 0.00150846590255829 NA NA NA hsa-miR-320b PIK3CA 0.300497419754843 0.0245219177384172 -0.342309377518198 0.000115361959187206 miRanda -0.109684919459557 0.00295331979925903 NA NA NA hsa-miR-339-5p PIK3CA 0.322848334531193 0.0117281778821612 -0.342309377518198 0.000115361959187206 miRanda -0.156390103299638 4.31357238138231e-05 NA NA NA hsa-miR-590-3p PIK3CA 1.13702599385212 3.53435739887793e-22 -0.342309377518198 0.000115361959187206 miRanda;mirMAP -0.167970910292111 1.76355187639927e-05 NA NA NA hsa-miR-590-5p PIK3CA 0.709763558412506 1.11883921359361e-11 -0.342309377518198 0.000115361959187206 miRanda -0.179027916238388 8.77558290901021e-05 NA NA NA hsa-miR-130b-3p PIK3CB 1.12788913578446 2.939369462276e-16 -0.247995112719303 0.00148503458375338 miRNATAP -0.166034631736904 1.58184303321712e-08 NA NA NA hsa-miR-19a-3p PIK3CB 0.722913586880779 2.76301458932381e-10 -0.247995112719303 0.00148503458375338 miRNATAP -0.138948641019506 0.000146950619817948 NA NA NA hsa-miR-19b-3p PIK3CB 0.195940928879427 0.0300512922542325 -0.247995112719303 0.00148503458375338 miRNATAP -0.155249167038679 0.00123255333914152 NA NA NA hsa-miR-25-3p PIK3CB 1.12016166564779 3.79069348635778e-48 -0.247995112719303 0.00148503458375338 miRNATAP -0.168848015389201 0.000511445370430535 NA NA NA hsa-miR-590-3p PIK3CB 1.13702599385212 3.53435739887793e-22 -0.247995112719303 0.00148503458375338 miRNATAP -0.152204162601648 8.6055969781532e-06 NA NA NA hsa-miR-92b-3p PIK3CB 0.418630595140165 6.50466149211154e-05 -0.247995112719303 0.00148503458375338 miRNATAP -0.132204554754912 0.00123182058684873 NA NA NA hsa-miR-10b-5p PIK3CD -0.89971464210447 1.18190532299934e-20 0.827862115800704 6.93199253004924e-19 miRNAWalker2_validate -0.322882758324939 5.32986923354336e-10 NA NA NA hsa-miR-1468-5p PIK3CD -0.311126383179539 0.00979113361106863 0.827862115800704 6.93199253004924e-19 MirTarget -0.200155097962759 8.08016260976088e-06 NA NA NA hsa-miR-30a-5p PIK3CD -0.778411951775343 2.73322451127932e-16 0.827862115800704 6.93199253004924e-19 miRNAWalker2_validate;MirTarget;miRNATAP -0.206007694378125 0.000161176631172019 23486085 miR 30a suppresses cell migration and invasion through downregulation of PIK3CD in colorectal carcinoma; A luciferase reporter assay was performed to determine target association between miR-30a and phosphoinositide 3-kinase catalytic subunit delta PIK3CD miR-30a was significantly downregulated in highly metastatic CRC cell lines and metastatic tissues; Further studies revealed that PIK3CD is a direct target of miR-30a as miR-30a bounds directly to the 3'-UTR of PIK3CD subsequently reducing its expression; Similar to the restoring miR-30a expression PIK3CD downregulation inhibited cell migration and invasion whereas PIK3CD overexpression rescued the suppressive effect of miR-30a; Moreover significant downregulation of miR-30a in metastatic CRC tissues was found to be inversely correlated with PIK3CD expression; Mechanistic studies revealed that miR-30a down-regulated the expression of key components of the Akt/mTOR pathway whereas PIK3CD overexpression reversed this negative effect cell migration colorectal cancer hsa-miR-30b-3p PIK3CD -1.64703050862226 1.89878531036464e-31 0.827862115800704 6.93199253004924e-19 MirTarget -0.256459682857462 3.84122966933957e-14 NA NA NA hsa-miR-30b-5p PIK3CD -1.18330589477119 6.8341618466966e-27 0.827862115800704 6.93199253004924e-19 MirTarget -0.212463225121162 2.43792629370427e-06 NA NA NA hsa-miR-30c-5p PIK3CD -1.08783070774238 2.02505402525786e-24 0.827862115800704 6.93199253004924e-19 MirTarget;miRNATAP -0.191697315876392 4.85249073283528e-05 NA NA NA hsa-miR-30d-5p PIK3CD -0.202727675788184 0.00659067084745794 0.827862115800704 6.93199253004924e-19 MirTarget;miRNATAP -0.209303428523125 0.00450077920142443 NA NA NA hsa-miR-106b-5p PIK3R1 1.07509411417907 2.11739194181878e-36 -0.234314125271815 0.0111750886765385 MirTarget;miRNATAP -0.179369079303185 0.000816789511004284 NA NA NA hsa-miR-221-3p PIK3R1 0.337895669520713 0.0136448974691037 -0.234314125271815 0.0111750886765385 MirTarget -0.163462882563838 9.21701112965761e-06 NA NA NA hsa-miR-222-3p PIK3R1 0.214811008033524 0.0965295551752457 -0.234314125271815 0.0111750886765385 MirTarget -0.107248741245045 0.00671314109485487 NA NA NA hsa-miR-590-3p PIK3R1 1.13702599385212 3.53435739887793e-22 -0.234314125271815 0.0111750886765385 miRanda;mirMAP -0.106905404095112 0.00880343764678398 NA NA NA hsa-miR-182-5p PIK3R3 -0.608710746044567 0.0025264935278104 0.439819702071113 8.25824839758606e-05 mirMAP -0.153374534942348 3.96734579923425e-07 NA NA NA hsa-miR-339-5p PIK3R3 0.322848334531193 0.0117281778821612 0.439819702071113 8.25824839758606e-05 MirTarget;miRanda -0.192609585710903 6.48743953207512e-05 NA NA NA hsa-miR-365a-3p PIK3R3 0.80809616164259 2.36039522526e-12 0.439819702071113 8.25824839758606e-05 MirTarget -0.16533292375838 0.00153486106521956 NA NA NA hsa-miR-96-5p PIK3R3 -1.00223771166604 3.91564621567028e-06 0.439819702071113 8.25824839758606e-05 mirMAP -0.164731670984697 7.78245878052581e-09 NA NA NA hsa-miR-125a-3p PIK3R5 -0.372794471295036 0.000941729459601642 3.18542758418586 6.04695754116875e-70 miRanda -0.407465916624748 0.000192324867439568 NA NA NA hsa-miR-125a-5p PIK3R5 -0.561874059994802 7.3931856356891e-13 3.18542758418586 6.04695754116875e-70 MirTarget;miRanda -1.34358622921882 2.31129700790236e-20 NA NA NA hsa-miR-125b-5p PIK3R5 -0.825456421494266 2.13029877878434e-15 3.18542758418586 6.04695754116875e-70 MirTarget -0.67295054872876 1.75325492827967e-09 NA NA NA hsa-miR-615-3p PIK3R5 -0.777370544471479 2.08193713560545e-08 3.18542758418586 6.04695754116875e-70 miRanda -0.258205105771951 0.00312779262258178 NA NA NA hsa-let-7a-3p PRKAA1 0.0677487960013088 0.460458477653989 -0.260138732323892 1.69329749121311e-05 MirTarget;mirMAP -0.170664098061315 3.04825742143563e-06 NA NA NA hsa-miR-128-3p PRKAA1 0.475045893035043 2.6255647468e-06 -0.260138732323892 1.69329749121311e-05 miRNAWalker2_validate -0.121392157891865 0.000212770714197567 NA NA NA hsa-miR-130b-3p PRKAA1 1.12788913578446 2.939369462276e-16 -0.260138732323892 1.69329749121311e-05 miRNAWalker2_validate;MirTarget;miRNATAP -0.140926378841502 5.73673657565669e-10 NA NA NA hsa-miR-152-3p PRKAA1 0.187079360533734 0.052276214844753 -0.260138732323892 1.69329749121311e-05 MirTarget -0.127797532450855 0.000252135257660719 NA NA NA hsa-miR-15a-5p PRKAA1 1.42663930007845 1.36006952074963e-57 -0.260138732323892 1.69329749121311e-05 MirTarget -0.146530517368934 2.79850891711554e-06 NA NA NA hsa-miR-15b-5p PRKAA1 0.773001494057531 1.71784656078957e-16 -0.260138732323892 1.69329749121311e-05 MirTarget -0.105659311284572 0.00205882307559636 NA NA NA hsa-miR-361-5p PRKAA1 0.0514169367202078 0.382929376393199 -0.260138732323892 1.69329749121311e-05 miRanda;mirMAP -0.196767314147676 0.000754478998270746 NA NA NA hsa-miR-374a-5p PRKAA1 0.543061152108237 2.19403097299769e-14 -0.260138732323892 1.69329749121311e-05 mirMAP -0.118837087025337 0.00982448274510836 NA NA NA hsa-miR-374b-5p PRKAA1 0.0804104684417872 0.365593963035077 -0.260138732323892 1.69329749121311e-05 mirMAP -0.160497688391478 2.28376581567227e-05 NA NA NA hsa-miR-590-3p PRKAA1 1.13702599385212 3.53435739887793e-22 -0.260138732323892 1.69329749121311e-05 MirTarget;miRanda;mirMAP -0.100422425089955 0.000171693829819552 NA NA NA hsa-miR-590-5p PRKAA1 0.709763558412506 1.11883921359361e-11 -0.260138732323892 1.69329749121311e-05 miRanda -0.118338434930148 0.000141551861605981 NA NA NA hsa-let-7f-1-3p PRKAA2 0.477913872379336 4.46669616865068e-05 -0.87603866571455 2.39442780121668e-15 mirMAP -0.263780540038395 5.50956898532686e-06 NA NA NA hsa-let-7i-5p PRKAA2 0.911372377723717 7.11483853341932e-31 -0.87603866571455 2.39442780121668e-15 MirTarget -0.521340871347098 3.51797118269534e-13 NA NA NA hsa-miR-106b-5p PRKAA2 1.07509411417907 2.11739194181878e-36 -0.87603866571455 2.39442780121668e-15 mirMAP -0.561008419639695 1.40295355889575e-18 NA NA NA hsa-miR-130b-3p PRKAA2 1.12788913578446 2.939369462276e-16 -0.87603866571455 2.39442780121668e-15 MirTarget -0.442606148320967 1.57359763568885e-27 NA NA NA hsa-miR-142-5p PRKAA2 1.88417391525707 1.2096808039882e-27 -0.87603866571455 2.39442780121668e-15 mirMAP -0.277329590795613 6.87769379184724e-18 NA NA NA hsa-miR-146a-5p PRKAA2 1.04938133739924 7.51013231709992e-12 -0.87603866571455 2.39442780121668e-15 MirTarget -0.22387192538863 1.50880432870166e-08 NA NA NA hsa-miR-146b-5p PRKAA2 1.40714170253819 2.9559871816487e-12 -0.87603866571455 2.39442780121668e-15 MirTarget -0.197867525814189 2.66987004459186e-11 NA NA NA hsa-miR-15b-3p PRKAA2 1.49422666971434 5.44139893275088e-29 -0.87603866571455 2.39442780121668e-15 mirMAP -0.231141735708372 7.80830768962165e-08 NA NA NA hsa-miR-16-2-3p PRKAA2 1.3046118743965 4.17207934608428e-19 -0.87603866571455 2.39442780121668e-15 mirMAP -0.259009177069492 1.20025521537756e-10 NA NA NA hsa-miR-17-5p PRKAA2 0.494260110870015 3.8348005261e-09 -0.87603866571455 2.39442780121668e-15 mirMAP -0.347407802884451 2.81209053239223e-06 NA NA NA hsa-miR-181a-5p PRKAA2 1.11111114875339 3.97880443756442e-29 -0.87603866571455 2.39442780121668e-15 mirMAP -0.244417397371591 3.05181640540662e-05 NA NA NA hsa-miR-181b-5p PRKAA2 1.49054296272357 3.69051660739368e-41 -0.87603866571455 2.39442780121668e-15 mirMAP -0.255999432850681 3.01615915831125e-07 NA NA NA hsa-miR-181c-5p PRKAA2 0.762784646696248 4.48373118147729e-10 -0.87603866571455 2.39442780121668e-15 mirMAP -0.211874970274251 2.73927951901985e-05 NA NA NA hsa-miR-186-5p PRKAA2 0.507217561043443 9.04455748270995e-10 -0.87603866571455 2.39442780121668e-15 MirTarget -0.205513902010596 0.00674376562749577 NA NA NA hsa-miR-19a-3p PRKAA2 0.722913586880779 2.76301458932381e-10 -0.87603866571455 2.39442780121668e-15 mirMAP -0.241221027262891 7.49463504984831e-06 NA NA NA hsa-miR-19b-3p PRKAA2 0.195940928879427 0.0300512922542325 -0.87603866571455 2.39442780121668e-15 mirMAP -0.289198255059485 4.25737427760059e-05 NA NA NA hsa-miR-20a-5p PRKAA2 0.702602695798242 4.06372887613329e-13 -0.87603866571455 2.39442780121668e-15 mirMAP -0.310012573471448 8.78891253965596e-07 NA NA NA hsa-miR-21-3p PRKAA2 1.78837590049697 1.41655409877312e-33 -0.87603866571455 2.39442780121668e-15 mirMAP -0.304749202368708 2.06454181165912e-16 NA NA NA hsa-miR-22-5p PRKAA2 -0.197038086012602 0.106234828461117 -0.87603866571455 2.39442780121668e-15 mirMAP -0.27261107883516 1.32334602748247e-07 NA NA NA hsa-miR-23a-3p PRKAA2 0.761438723382355 4.09310879199257e-27 -0.87603866571455 2.39442780121668e-15 mirMAP -0.427046075647863 2.69308141781555e-07 NA NA NA hsa-miR-301a-3p PRKAA2 0.259400847075798 0.0216890736701418 -0.87603866571455 2.39442780121668e-15 MirTarget -0.179107497760408 0.00152284038984636 NA NA NA hsa-miR-330-3p PRKAA2 0.912906550436308 3.35037014057665e-13 -0.87603866571455 2.39442780121668e-15 MirTarget -0.186398510055617 0.000189815043894567 NA NA NA hsa-miR-340-5p PRKAA2 1.14479851941741 2.91936881701444e-15 -0.87603866571455 2.39442780121668e-15 MirTarget -0.165779558262072 7.46810073042114e-05 NA NA NA hsa-miR-342-3p PRKAA2 1.4124432570595 1.07208971556131e-28 -0.87603866571455 2.39442780121668e-15 PITA -0.322613739383616 3.97034498752305e-13 NA NA NA hsa-miR-34a-5p PRKAA2 1.07544567720768 1.81510842038009e-20 -0.87603866571455 2.39442780121668e-15 miRNATAP -0.285122269195656 2.171285185067e-08 NA NA NA hsa-miR-374a-3p PRKAA2 1.13863935833993 2.79089304015401e-44 -0.87603866571455 2.39442780121668e-15 mirMAP -0.297581680432823 1.21073366123278e-05 NA NA NA hsa-miR-381-3p PRKAA2 -0.674906433524392 0.000234722307243307 -0.87603866571455 2.39442780121668e-15 MirTarget;mirMAP -0.125306211680771 0.000300417588748376 NA NA NA hsa-miR-382-5p PRKAA2 -0.318998563236146 0.0916726793289812 -0.87603866571455 2.39442780121668e-15 mirMAP -0.14950254744342 1.27894318008159e-05 NA NA NA hsa-miR-409-3p PRKAA2 -0.292481246887274 0.114186058216271 -0.87603866571455 2.39442780121668e-15 mirMAP -0.11250926731011 0.00118969485149345 NA NA NA hsa-miR-410-3p PRKAA2 -0.34067549519883 0.0571044968648058 -0.87603866571455 2.39442780121668e-15 MirTarget -0.118633935727201 0.00131070193754933 NA NA NA hsa-miR-452-3p PRKAA2 1.72039996672257 1.35748079442153e-22 -0.87603866571455 2.39442780121668e-15 mirMAP -0.131012616507734 0.000138020148054189 NA NA NA hsa-miR-454-3p PRKAA2 0.68285296887698 1.17407812677787e-08 -0.87603866571455 2.39442780121668e-15 MirTarget -0.237942271368452 4.23432285905385e-06 NA NA NA hsa-miR-576-5p PRKAA2 1.06681109513983 5.69294424466526e-24 -0.87603866571455 2.39442780121668e-15 mirMAP -0.279376628619257 5.01651126211661e-07 NA NA NA hsa-miR-589-5p PRKAA2 0.696241532021631 5.26958362886071e-16 -0.87603866571455 2.39442780121668e-15 MirTarget -0.312536653582043 1.02510906411518e-05 NA NA NA hsa-miR-590-3p PRKAA2 1.13702599385212 3.53435739887793e-22 -0.87603866571455 2.39442780121668e-15 mirMAP;miRNATAP -0.302232071708348 1.39119727787578e-09 NA NA NA hsa-miR-93-5p PRKAA2 1.37365940377595 2.37567548683245e-46 -0.87603866571455 2.39442780121668e-15 mirMAP -0.354497458287063 3.00032412864335e-10 NA NA NA hsa-miR-338-5p RHEB 0.628429807914222 1.27575140717947e-06 -0.104787111957932 0.127227094860821 MirTarget;PITA;miRNATAP -0.167905557267255 4.63175919787163e-09 NA NA NA hsa-let-7a-3p RICTOR 0.0677487960013088 0.460458477653989 -0.20152927768336 0.00291211809900196 MirTarget;miRNATAP -0.19537141644543 1.53004027000547e-06 NA NA NA hsa-let-7d-5p RICTOR -0.0696879530236796 0.333110939877203 -0.20152927768336 0.00291211809900196 MirTarget;miRNATAP -0.213627971219031 4.63649462018669e-05 NA NA NA hsa-miR-152-3p RICTOR 0.187079360533734 0.052276214844753 -0.20152927768336 0.00291211809900196 MirTarget -0.183766036477124 1.89718063278888e-06 21868754 We identified E2F3 MET and Rictor as novel candidate targets of miR-152 suggesting how its epigenetic silencing can drive endometrial carcinogenesis tumorigenesis endometrial cancer hsa-miR-15a-5p RICTOR 1.42663930007845 1.36006952074963e-57 -0.20152927768336 0.00291211809900196 MirTarget;miRNATAP -0.120424117003709 0.000595201554550583 NA NA NA hsa-miR-15b-5p RICTOR 0.773001494057531 1.71784656078957e-16 -0.20152927768336 0.00291211809900196 MirTarget;miRNATAP -0.137077098579119 0.000314703241598516 NA NA NA hsa-miR-16-5p RICTOR 0.934012514027655 4.85417898318515e-24 -0.20152927768336 0.00291211809900196 MirTarget;miRNATAP -0.116086769113587 0.00212303009436505 NA NA NA hsa-miR-186-5p RICTOR 0.507217561043443 9.04455748270995e-10 -0.20152927768336 0.00291211809900196 mirMAP -0.146996049412798 0.000907551521345102 NA NA NA hsa-miR-18a-5p RICTOR 0.936704393213466 1.05064580570579e-10 -0.20152927768336 0.00291211809900196 miRNAWalker2_validate -0.107950803342382 1.38206152210299e-05 NA NA NA hsa-miR-195-5p RICTOR 0.346502644882604 0.0092562828415903 -0.20152927768336 0.00291211809900196 MirTarget;miRNATAP -0.129217058970698 3.19064591314051e-06 NA NA NA hsa-miR-19b-3p RICTOR 0.195940928879427 0.0300512922542325 -0.20152927768336 0.00291211809900196 MirTarget;miRNATAP -0.12303268869792 0.00313074802227158 NA NA NA hsa-miR-27a-3p RICTOR 0.558934437526245 1.44256383086177e-12 -0.20152927768336 0.00291211809900196 miRNATAP -0.259200506582187 1.07888405783658e-08 NA NA NA hsa-miR-330-5p RICTOR 1.44960468659754 2.12131210588035e-45 -0.20152927768336 0.00291211809900196 miRanda -0.10832191383008 0.00061646130266705 NA NA NA hsa-miR-365a-3p RICTOR 0.80809616164259 2.36039522526e-12 -0.20152927768336 0.00291211809900196 MirTarget -0.110839452066667 0.000399271332508793 NA NA NA hsa-miR-497-5p RICTOR 0.227757383708836 0.0600073987853074 -0.20152927768336 0.00291211809900196 MirTarget;miRNATAP -0.148650761530948 1.15380351823955e-06 NA NA NA hsa-miR-98-5p RICTOR 0.0569715596189075 0.450575962846765 -0.20152927768336 0.00291211809900196 MirTarget -0.13073866267368 0.00936092115438781 NA NA NA hsa-miR-652-3p RPS6 -0.204082397854575 0.0116383615097732 0.449152759767772 1.98262666572569e-09 miRNAWalker2_validate -0.16820732198418 0.00137735696499373 NA NA NA hsa-miR-744-5p RPS6 -0.348985243196771 0.000187889982228835 0.449152759767772 1.98262666572569e-09 miRNAWalker2_validate -0.175897996517356 8.93552190904733e-05 NA NA NA hsa-miR-125a-5p RPS6KA1 -0.561874059994802 7.3931856356891e-13 -0.433399736446167 2.70094734091811e-08 MirTarget;PITA;miRanda -0.143926345210058 0.00836948308852458 NA NA NA hsa-miR-20a-5p RPS6KA1 0.702602695798242 4.06372887613329e-13 -0.433399736446167 2.70094734091811e-08 miRNATAP -0.142778602196398 0.00110068159758392 NA NA NA hsa-miR-330-5p RPS6KA1 1.44960468659754 2.12131210588035e-45 -0.433399736446167 2.70094734091811e-08 miRanda -0.100083238991652 0.00716514477264792 NA NA NA hsa-miR-93-5p RPS6KA1 1.37365940377595 2.37567548683245e-46 -0.433399736446167 2.70094734091811e-08 miRNATAP -0.136988620554412 0.000519864798722955 NA NA NA hsa-miR-130b-5p RPS6KA2 0.92990617673277 3.75880436852717e-12 -0.212211114338083 0.0475241240943583 mirMAP -0.177208577567739 2.9086708991819e-05 NA NA NA hsa-miR-17-5p RPS6KA2 0.494260110870015 3.8348005261e-09 -0.212211114338083 0.0475241240943583 TargetScan -0.223467482842844 0.00125580166887693 NA NA NA hsa-miR-185-3p RPS6KA2 0.993379985307475 2.62011454953707e-13 -0.212211114338083 0.0475241240943583 MirTarget -0.172188563819846 4.57331956946955e-05 NA NA NA hsa-miR-193b-3p RPS6KA2 -0.273325765316079 0.104328826585392 -0.212211114338083 0.0475241240943583 mirMAP -0.254245075710105 5.62254173997602e-14 NA NA NA hsa-miR-19a-3p RPS6KA2 0.722913586880779 2.76301458932381e-10 -0.212211114338083 0.0475241240943583 MirTarget -0.146854125264348 0.00350582708389517 NA NA NA hsa-miR-21-3p RPS6KA2 1.78837590049697 1.41655409877312e-33 -0.212211114338083 0.0475241240943583 MirTarget -0.131230323868777 0.000243180115333484 NA NA NA hsa-miR-3127-5p RPS6KA2 0.952801473575318 5.81162987769266e-14 -0.212211114338083 0.0475241240943583 mirMAP -0.130757843393535 0.00506553280635018 NA NA NA hsa-miR-378a-3p RPS6KA2 0.287244802401236 0.0501155019984562 -0.212211114338083 0.0475241240943583 MirTarget -0.249486334772224 2.18584952163243e-10 NA NA NA hsa-miR-378c RPS6KA2 0.755048315231594 3.56147090439556e-06 -0.212211114338083 0.0475241240943583 MirTarget -0.176896357089749 6.79794300094522e-07 NA NA NA hsa-miR-589-5p RPS6KA2 0.696241532021631 5.26958362886071e-16 -0.212211114338083 0.0475241240943583 mirMAP -0.366271008637334 1.72508460204289e-08 NA NA NA hsa-miR-106b-5p RPS6KA3 1.07509411417907 2.11739194181878e-36 -0.0569263656430596 0.481222370733631 miRNATAP -0.153826494720885 0.00097792160434743 NA NA NA hsa-miR-181c-5p RPS6KA3 0.762784646696248 4.48373118147729e-10 -0.0569263656430596 0.481222370733631 MirTarget;mirMAP;miRNATAP -0.101641507041936 0.00409231381726318 NA NA NA hsa-miR-1271-5p RPS6KA6 0.900599702972936 3.07963385418853e-10 -5.02319609647308 2.00514288352531e-35 MirTarget -0.526970657354953 0.00189389477393479 NA NA NA hsa-miR-15a-5p RPS6KA6 1.42663930007845 1.36006952074963e-57 -5.02319609647308 2.00514288352531e-35 MirTarget -2.53085785588334 1.26093387994038e-32 NA NA NA hsa-miR-15b-5p RPS6KA6 0.773001494057531 1.71784656078957e-16 -5.02319609647308 2.00514288352531e-35 MirTarget -1.99934410555447 2.48804031191179e-16 NA NA NA hsa-miR-16-5p RPS6KA6 0.934012514027655 4.85417898318515e-24 -5.02319609647308 2.00514288352531e-35 MirTarget -2.16602770116441 1.23379955733856e-19 NA NA NA hsa-miR-17-5p RPS6KA6 0.494260110870015 3.8348005261e-09 -5.02319609647308 2.00514288352531e-35 TargetScan -1.69854589208916 3.39759866761013e-09 NA NA NA hsa-miR-192-3p RPS6KA6 0.156650099616707 0.483496040900362 -5.02319609647308 2.00514288352531e-35 MirTarget -0.33484926706264 0.00285293688546284 NA NA NA hsa-miR-195-5p RPS6KA6 0.346502644882604 0.0092562828415903 -5.02319609647308 2.00514288352531e-35 MirTarget -0.745611028885755 6.17026051423213e-05 NA NA NA hsa-miR-19a-3p RPS6KA6 0.722913586880779 2.76301458932381e-10 -5.02319609647308 2.00514288352531e-35 MirTarget -1.30081845054165 3.7558599964014e-10 NA NA NA hsa-miR-19b-3p RPS6KA6 0.195940928879427 0.0300512922542325 -5.02319609647308 2.00514288352531e-35 MirTarget -1.21825669990333 1.00629204767186e-05 NA NA NA hsa-miR-374a-5p RPS6KA6 0.543061152108237 2.19403097299769e-14 -5.02319609647308 2.00514288352531e-35 MirTarget -1.94743185919819 6.17504231911122e-09 NA NA NA hsa-miR-374b-3p RPS6KA6 0.611842481331529 3.85718194756943e-07 -5.02319609647308 2.00514288352531e-35 MirTarget -0.740672664375455 0.000438072946812851 NA NA NA hsa-miR-497-5p RPS6KA6 0.227757383708836 0.0600073987853074 -5.02319609647308 2.00514288352531e-35 MirTarget -0.624919365272913 0.00247184613892212 NA NA NA hsa-miR-590-3p RPS6KA6 1.13702599385212 3.53435739887793e-22 -5.02319609647308 2.00514288352531e-35 MirTarget;miRanda;mirMAP;miRNATAP -1.66662709717755 1.36127745738836e-18 NA NA NA hsa-miR-27b-3p RPS6KB1 -0.699527231242518 1.07356023759234e-15 0.303647491711929 1.02371800091672e-12 MirTarget;miRNATAP -0.172730029206028 2.47756684572158e-11 NA NA NA hsa-miR-30a-5p RPS6KB1 -0.778411951775343 2.73322451127932e-16 0.303647491711929 1.02371800091672e-12 mirMAP;miRNATAP -0.103881286441487 1.65257096229915e-05 NA NA NA hsa-miR-30b-5p RPS6KB1 -1.18330589477119 6.8341618466966e-27 0.303647491711929 1.02371800091672e-12 mirMAP -0.127044992502865 1.09039842876316e-10 NA NA NA hsa-miR-125a-5p RPS6KB2 -0.561874059994802 7.3931856356891e-13 0.641017701791616 2.75511443301856e-15 miRanda -0.395210282665904 2.31643815758657e-12 NA NA NA hsa-miR-1296-5p RPS6KB2 -0.992767487650773 3.35721559985878e-13 0.641017701791616 2.75511443301856e-15 miRNAWalker2_validate -0.144382822212672 1.07027776390907e-05 NA NA NA hsa-miR-106b-5p TSC1 1.07509411417907 2.11739194181878e-36 -0.00580613989838064 0.940526093561656 miRNAWalker2_validate -0.120840871153662 0.00727646944499296 NA NA NA hsa-miR-130b-5p TSC1 0.92990617673277 3.75880436852717e-12 -0.00580613989838064 0.940526093561656 mirMAP -0.161569736231416 1.0730295312716e-07 NA NA NA hsa-miR-140-5p TSC1 0.504309496243674 3.09884038729031e-11 -0.00580613989838064 0.940526093561656 miRanda -0.165004418084686 0.00278970296993013 NA NA NA hsa-miR-142-3p TSC1 1.88928758773299 2.72985643829893e-22 -0.00580613989838064 0.940526093561656 miRanda -0.100360531766426 6.95935714452328e-07 NA NA NA hsa-miR-150-5p TSC1 1.00371863159681 1.09871676395528e-09 -0.00580613989838064 0.940526093561656 mirMAP -0.105215447234603 2.72945643857383e-05 NA NA NA hsa-miR-186-5p TSC1 0.507217561043443 9.04455748270995e-10 -0.00580613989838064 0.940526093561656 mirMAP -0.329715504594276 2.40364473068977e-11 NA NA NA hsa-miR-193a-5p TSC1 1.29777740059595 2.16815694068336e-39 -0.00580613989838064 0.940526093561656 mirMAP -0.186472134336862 8.61069871222992e-07 NA NA NA hsa-miR-197-3p TSC1 0.297760714271229 0.00102679606305048 -0.00580613989838064 0.940526093561656 mirMAP -0.248373692373176 9.00704159638638e-08 NA NA NA hsa-miR-23a-3p TSC1 0.761438723382355 4.09310879199257e-27 -0.00580613989838064 0.940526093561656 mirMAP -0.234478582453751 2.79325447109095e-05 NA NA NA hsa-miR-28-3p TSC1 1.01277915413238 1.8655970171461e-43 -0.00580613989838064 0.940526093561656 PITA -0.221693676045417 1.36868877784546e-05 NA NA NA hsa-miR-29a-5p TSC1 -0.519003718107105 1.03351148282116e-06 -0.00580613989838064 0.940526093561656 mirMAP -0.116658848056744 0.00333129068504756 NA NA NA hsa-miR-29b-1-5p TSC1 0.0773574972948876 0.542823265430415 -0.00580613989838064 0.940526093561656 mirMAP -0.143974607612096 1.70166692972594e-05 NA NA NA hsa-miR-320a TSC1 0.412740558379182 2.02929519701706e-05 -0.00580613989838064 0.940526093561656 miRNAWalker2_validate;miRanda -0.172381374186791 7.779409765497e-05 NA NA NA hsa-miR-320b TSC1 0.300497419754843 0.0245219177384172 -0.00580613989838064 0.940526093561656 miRanda -0.147538662754558 3.10353146784042e-06 NA NA NA hsa-miR-339-5p TSC1 0.322848334531193 0.0117281778821612 -0.00580613989838064 0.940526093561656 miRanda -0.156420585582284 2.07930704169104e-06 NA NA NA hsa-miR-495-3p TSC1 -0.742293735164333 7.11373308013543e-05 -0.00580613989838064 0.940526093561656 mirMAP -0.112996786535522 9.57369310781159e-07 NA NA NA hsa-miR-576-5p TSC1 1.06681109513983 5.69294424466526e-24 -0.00580613989838064 0.940526093561656 mirMAP -0.159651820548827 1.98607445752694e-05 NA NA NA hsa-miR-7-1-3p TSC1 0.544601828025304 5.33830451326047e-07 -0.00580613989838064 0.940526093561656 mirMAP -0.126117369350671 0.00113875962691901 NA NA NA hsa-miR-106a-5p ULK1 -0.830908656792615 2.67547872901508e-10 0.385454244355346 1.12537467193916e-05 miRNATAP -0.170109255442055 2.06513828989338e-06 27372519 This ULK1 upregulation is caused by downregulation of the ULK1-targeting microRNA-106a; An inverse correlation of miR-106a and ULK1 expression was seen in lung adenocarcinoma lung cancer hsa-miR-186-5p ULK1 0.507217561043443 9.04455748270995e-10 0.385454244355346 1.12537467193916e-05 miRNAWalker2_validate -0.253352715879871 1.11014984105817e-05 NA NA NA hsa-miR-20b-5p ULK1 -1.30218163823367 6.87172815978149e-17 0.385454244355346 1.12537467193916e-05 miRNATAP -0.16533452930834 1.79263840726434e-08 NA NA NA hsa-miR-26b-5p ULK1 -0.251437253429904 0.00270935785098697 0.385454244355346 1.12537467193916e-05 miRNATAP -0.274111553748684 2.34070118776665e-06 NA NA NA hsa-miR-320a ULK1 0.412740558379182 2.02929519701706e-05 0.385454244355346 1.12537467193916e-05 miRNAWalker2_validate;miRNATAP -0.178522748310302 0.000365565597072246 NA NA NA hsa-miR-320b ULK1 0.300497419754843 0.0245219177384172 0.385454244355346 1.12537467193916e-05 miRNATAP -0.102654561583692 0.0050708124042944 NA NA NA hsa-miR-423-5p ULK1 0.250929012519631 0.00288495915028486 0.385454244355346 1.12537467193916e-05 miRNAWalker2_validate -0.309790755896046 7.14898019170063e-08 NA NA NA hsa-miR-22-3p ULK2 0.198460552200729 0.00761005672059428 -0.126876848259589 0.0291583463250277 MirTarget -0.121278113889812 0.00524583304311028 NA NA NA hsa-miR-125a-5p ULK3 -0.561874059994802 7.3931856356891e-13 0.216568387418821 0.0294032424618886 PITA -0.309372743547042 4.74531040700854e-06 NA NA NA hsa-miR-326 ULK3 0.0283498662828876 0.83943976716391 0.216568387418821 0.0294032424618886 miRanda -0.203457873984826 1.52347118664733e-07 NA NA NA hsa-miR-491-5p ULK3 -0.0898777415179634 0.533906535063567 0.216568387418821 0.0294032424618886 miRanda -0.10798273320602 0.00690166723449914 NA NA NA hsa-miR-1-3p VEGFA -1.38047704190737 9.11649491260066e-13 3.1902151031465 4.32161998112301e-60 MirTarget -0.377004508862683 2.92409820832604e-09 24966896 The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation P<0.01 and reduced gene expression of VEGF-A and AXL bladder cancer hsa-miR-106a-5p VEGFA -0.830908656792615 2.67547872901508e-10 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase -0.565883993248695 1.96742640916183e-09 NA NA NA hsa-miR-125a-5p VEGFA -0.561874059994802 7.3931856356891e-13 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRanda -0.691987422405189 1.65186087473265e-05 22768249 Ectopic expression of MiR 125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF; Furthermore miR-125a expression was inversely correlated with both MMP11 and VEGF-A expression in HCC tissues; MiR-125a inhibits the proliferation and metastasis of HCC by targeting MMP11 and VEGF-A metastasis liver cancer hsa-miR-133a-3p VEGFA -1.27121745308165 9.16266399887975e-11 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate -0.334559517340425 1.60041057990039e-07 NA NA NA hsa-miR-134-5p VEGFA -0.940639322366899 1.24417590236773e-06 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget -0.273283677460691 3.09936265314409e-05 NA NA NA hsa-miR-199a-5p VEGFA -1.64658415208633 1.01615659358973e-23 3.1902151031465 4.32161998112301e-60 miRanda;miRNATAP -0.582562369754787 1.33420730972332e-16 25444917 In addition co-transfection with miR-199a mimic reversed the CCL5-mediated VEGF expression and angiogenesis in vitro and in vivo sarcoma hsa-miR-199b-5p VEGFA -2.39483476763681 1.04659509514884e-17 3.1902151031465 4.32161998112301e-60 miRanda -0.388055722385546 8.86533920644866e-20 NA NA NA hsa-miR-200b-3p VEGFA -1.70383252137161 2.38979336321755e-30 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.652162092625576 6.74456951743668e-18 20420713;22904162;25301739 We also found strong anti-correlation between VEGFA and the miR-200 family of microRNA: miR-200a* 200b 200c and miR-141;In contrast a positive correlation was observed between VEGF-A and miR-200b and -210;CCL5 promotes VEGF dependent angiogenesis by down regulating miR 200b through PI3K/Akt signaling pathway in human chondrosarcoma cells; We also demonstrated CCL5 inhibiting miR-200b expression and miR-200b mimic reversing the CCL5-enhanced VEGF expression and angiogenesis ;; kidney renal cell cancer;endometrial cancer;sarcoma hsa-miR-200c-3p VEGFA -5.40303134829523 2.74173143360645e-94 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget -0.482839305599163 5.43978252023974e-53 24205206;25445393 MiR 200c increases the radiosensitivity of non small cell lung cancer cell line A549 by targeting VEGF VEGFR2 pathway;Analysis revealed a negative correlation between miR-200c and VEGFA expressions r=-468 ; lung squamous cell cancer;breast cancer hsa-miR-20b-5p VEGFA -1.30218163823367 6.87172815978149e-17 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase -0.658858628437659 2.63194222583861e-18 22901144;20232316;26612965 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha;We investigated whether and how miR-20b can regulate the expression of vascular endothelial growth factor VEGF in MCF-7 breast cancer cells under normoxic and hypoxia-mimicking conditions CoCl2 exposure; Using immunoblotting ELISA and quantitative real-time PCR we demonstrated that miR-20b decreased VEGF protein levels at 4 and 24 h following CoCl2 treatment and VEGF mRNA at 4 h of treatment; In addition miR-20b reduced VEGF protein expression in untreated cells;Clinicopathological Significance of MicroRNA 20b Expression in Hepatocellular Carcinoma and Regulation of HIF 1α and VEGF Effect on Cell Biological Behaviour; Meanwhile the HIF-1α and VEGF targets of miR-20b have been confirmed; We found not only miR-20b regulation of HIF-1α and VEGF in normal but also regulation of miR-20b in hypoxia; The whole study suggests that miR-20b HIF-1α and VEGF serve as a potential therapeutic agent for hepatocellular carcinoma ;; breast cancer;breast cancer;liver cancer hsa-miR-29a-3p VEGFA -0.431613225927952 4.10166815070288e-08 3.1902151031465 4.32161998112301e-60 MirTarget -1.19030784245849 4.8715212353082e-14 24209632 miR 29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF A; Furthermore western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A VEGF-A is direct target of miR-29a; This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A gastric cancer hsa-miR-29b-2-5p VEGFA -0.297854154636098 0.00260919277325581 3.1902151031465 4.32161998112301e-60 MirTarget -0.376634138151447 0.00423612473269059 NA NA NA hsa-miR-29b-3p VEGFA -0.228125979913806 0.0271621721891603 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate;miRTarBase;MirTarget -0.569482283980511 5.47301472525388e-06 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-335-5p VEGFA -2.09515619961552 1.03765771499548e-25 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate -0.560731405851007 4.75077750352693e-23 NA NA NA hsa-miR-362-3p VEGFA -0.753214251798232 3.0025661608035e-07 3.1902151031465 4.32161998112301e-60 miRanda -0.478977237100648 5.87028343678109e-08 NA NA NA hsa-miR-429 VEGFA -2.16569233119434 2.66862243626443e-37 3.1902151031465 4.32161998112301e-60 MirTarget;miRanda;miRNATAP -0.567681641585143 1.7112668371199e-18 NA NA NA hsa-miR-9-5p VEGFA -2.23538606210968 1.28143998950751e-12 3.1902151031465 4.32161998112301e-60 miRNAWalker2_validate -0.222102357667036 1.24335781156383e-08 NA NA NA hsa-miR-125a-5p VEGFB -0.561874059994802 7.3931856356891e-13 0.889287998012356 1.57204399120492e-27 miRanda -0.312191565292049 2.15759355844345e-07 NA NA NA