miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-139-5p A2ML1 -0.292245043386175 0.603867611856128 6.19876063063878 4.89671675790989e-39 miRanda -0.251517758397988 0.00301165361367376 NA NA NA hsa-miR-199a-5p A2ML1 -0.588848186292807 0.534893742254242 6.19876063063878 4.89671675790989e-39 miRanda -0.432571184240284 0.000217337915123593 NA NA NA hsa-miR-199b-5p A2ML1 -0.489883928472198 0.514360594242384 6.19876063063878 4.89671675790989e-39 miRanda -0.296804748667495 0.00506696877048679 NA NA NA hsa-miR-107 ABCC11 0.351433472692356 0.523819413335979 -5.22207560981697 8.97460458663762e-24 miRanda -0.973656218632444 2.33767498021616e-09 NA NA NA hsa-miR-590-5p ABCC11 1.40236682288609 3.89322108176281e-06 -5.22207560981697 8.97460458663762e-24 miRanda -0.788841564590778 3.41963595746401e-14 NA NA NA hsa-miR-582-5p ABCC8 0.84770952065171 0.000866226913967834 -6.02087352689893 5.70978722468163e-42 MirTarget;PITA;miRNATAP -0.617958243121565 9.19614471588165e-11 NA NA NA hsa-miR-197-3p AGR2 1.20017939489121 0.103913584580121 -6.37554175383822 1.98251184401511e-17 miRNAWalker2_validate -1.68574175780256 6.5547384787494e-48 NA NA NA hsa-miR-361-5p AGR2 0.295581181703002 0.679805903809273 -6.37554175383822 1.98251184401511e-17 miRanda -1.30944297393499 3.25322476462752e-08 NA NA NA hsa-miR-590-3p AGR2 1.01238246880436 6.25794947126089e-07 -6.37554175383822 1.98251184401511e-17 miRanda -0.809565281921211 2.84456843816196e-13 NA NA NA hsa-miR-455-5p AGR3 1.38138264178539 0.00151082519157593 -8.26487772978584 1.1787998364795e-36 MirTarget;miRanda -1.45524738102036 8.18693111378524e-33 NA NA NA hsa-miR-590-3p AGR3 1.01238246880436 6.25794947126089e-07 -8.26487772978584 1.1787998364795e-36 miRanda -1.19175849222747 9.88768334064096e-19 NA NA NA hsa-miR-193a-3p ANKRD30A 0.183521555169311 0.61877899263343 -7.37842215333421 2.79087625963359e-33 miRanda -0.457069499844912 0.00514291409255925 NA NA NA hsa-miR-107 ANKRD30B 0.351433472692356 0.523819413335979 -6.07487791891269 1.69040314792979e-43 miRanda -0.856226968558973 1.28288799275869e-07 NA NA NA hsa-miR-142-3p ANKRD30B 1.18219258029821 0.19611934127025 -6.07487791891269 1.69040314792979e-43 miRanda -0.339789144938944 3.85922440854509e-06 NA NA NA hsa-miR-320b ANKRD30B 0.712468682578545 0.00260489977004221 -6.07487791891269 1.69040314792979e-43 miRanda -0.530638483499459 8.5517066064653e-07 NA NA NA hsa-miR-455-5p ANKRD30B 1.38138264178539 0.00151082519157593 -6.07487791891269 1.69040314792979e-43 miRanda -1.1284152211834 4.49774178434938e-31 NA NA NA hsa-miR-590-3p ANKRD30B 1.01238246880436 6.25794947126089e-07 -6.07487791891269 1.69040314792979e-43 miRanda -0.738250664560673 9.66215111390277e-12 NA NA NA hsa-miR-199a-5p ART3 -0.588848186292807 0.534893742254242 5.21132712243671 5.2413842613757e-31 miRanda -0.525835045536482 1.82102183393148e-07 NA NA NA hsa-miR-199b-5p ART3 -0.489883928472198 0.514360594242384 5.21132712243671 5.2413842613757e-31 miRanda -0.2373700238187 0.00959719583044877 NA NA NA hsa-miR-130a-3p C1orf64 0.849038376258018 0.133664106340641 -7.39016164055348 2.54469819029786e-41 mirMAP -0.702593758350427 4.92713739609523e-09 NA NA NA hsa-miR-17-3p C1orf64 1.46616632235897 0.0418591337484843 -7.39016164055348 2.54469819029786e-41 mirMAP -1.78398004063793 4.75223190769519e-44 NA NA NA hsa-miR-301a-3p C1orf64 0.968506401137921 0.000570564850124159 -7.39016164055348 2.54469819029786e-41 mirMAP -0.937922045966999 3.43065570451609e-24 NA NA NA hsa-miR-32-5p C1orf64 0.531860098119996 0.195500436097555 -7.39016164055348 2.54469819029786e-41 mirMAP -0.784661307435301 5.41738457823338e-09 NA NA NA hsa-miR-454-3p C1orf64 0.427403467632791 0.11673336658399 -7.39016164055348 2.54469819029786e-41 mirMAP -0.696413614592968 1.02149832484951e-09 NA NA NA hsa-miR-576-5p C1orf64 1.29396616748627 4.70941163094532e-05 -7.39016164055348 2.54469819029786e-41 mirMAP -1.54124404877186 3.44917447485306e-33 NA NA NA hsa-miR-125a-3p CEACAM5 0.179529841024673 0.416182564332207 -5.33870404002197 3.11061670840989e-25 miRanda -0.615782416591243 3.10667825466131e-05 NA NA NA hsa-miR-335-5p CEACAM5 0.0404259244994374 0.914858946651589 -5.33870404002197 3.11061670840989e-25 miRNAWalker2_validate -0.479407056537049 1.95839103058109e-08 NA NA NA hsa-miR-361-5p CEACAM5 0.295581181703002 0.679805903809273 -5.33870404002197 3.11061670840989e-25 miRanda -2.31521914128641 2.09639665094983e-18 NA NA NA hsa-miR-130b-5p CT62 1.3947936173305 4.50465898911354e-07 -5.00527219616983 2.33681538423044e-51 mirMAP -0.735693991332473 5.46880392841412e-29 NA NA NA hsa-miR-330-5p CT62 0.563423954500856 0.194785172695321 -5.00527219616983 2.33681538423044e-51 miRanda -0.554755659229098 1.11914938407765e-08 NA NA NA hsa-miR-500a-5p CT62 1.189064348723 1.51345772748382e-08 -5.00527219616983 2.33681538423044e-51 mirMAP -1.04941669430028 3.26706185153437e-45 NA NA NA hsa-miR-590-3p CT62 1.01238246880436 6.25794947126089e-07 -5.00527219616983 2.33681538423044e-51 mirMAP -0.776731138580433 1.71039291973305e-21 NA NA NA hsa-let-7f-1-3p ERBB4 0.541305090676599 0.000810726288280833 -5.37185314288958 2.30708721608433e-25 mirMAP -0.553183235017237 4.20128842757918e-08 NA NA NA hsa-miR-107 ERBB4 0.351433472692356 0.523819413335979 -5.37185314288958 2.30708721608433e-25 miRanda -0.855347153920767 1.18282675367512e-09 NA NA NA hsa-miR-125b-2-3p ERBB4 0.295384471337631 0.494858321261013 -5.37185314288958 2.30708721608433e-25 MirTarget -0.164848367344315 0.0310337686136616 NA NA NA hsa-miR-130a-3p ERBB4 0.849038376258018 0.133664106340641 -5.37185314288958 2.30708721608433e-25 miRNATAP -0.562452691608941 2.75206032603849e-10 NA NA NA hsa-miR-130b-3p ERBB4 1.16970507422762 6.85086072809354e-05 -5.37185314288958 2.30708721608433e-25 miRNATAP -1.07821928091649 4.74671059403323e-36 NA NA NA hsa-miR-130b-5p ERBB4 1.3947936173305 4.50465898911354e-07 -5.37185314288958 2.30708721608433e-25 miRNATAP -0.86553972453535 7.04276245447973e-31 NA NA NA hsa-miR-140-5p ERBB4 0.781948085004431 0.101152958138705 -5.37185314288958 2.30708721608433e-25 PITA -0.683275679037952 2.69850298884891e-09 NA NA NA hsa-miR-142-5p ERBB4 1.23477289272799 0.0150054709615798 -5.37185314288958 2.30708721608433e-25 PITA;mirMAP -0.606955585207464 6.19801919435736e-17 NA NA NA hsa-miR-146a-5p ERBB4 1.50457049554322 0.0123735084940492 -5.37185314288958 2.30708721608433e-25 miRNAWalker2_validate;miRTarBase;miRNATAP -0.771575520291238 1.17420575349542e-22 NA NA NA hsa-miR-146b-5p ERBB4 0.876334790841257 0.284935762703604 -5.37185314288958 2.30708721608433e-25 PITA;miRNATAP -1.13034904758223 6.83333476872108e-31 NA NA NA hsa-miR-148a-5p ERBB4 0.753389367124705 0.119008143405913 -5.37185314288958 2.30708721608433e-25 mirMAP -0.667114217154113 5.86281080130145e-12 NA NA NA hsa-miR-155-5p ERBB4 1.12529442422533 0.131933535981501 -5.37185314288958 2.30708721608433e-25 mirMAP -0.94286258454739 1.01774388894949e-31 NA NA NA hsa-miR-181a-5p ERBB4 0.206424802853514 0.833057626260378 -5.37185314288958 2.30708721608433e-25 mirMAP -0.712832047447049 3.05402907910176e-09 NA NA NA hsa-miR-181b-5p ERBB4 0.515446560070718 0.50566125221377 -5.37185314288958 2.30708721608433e-25 mirMAP -0.767721858342024 2.65150063570159e-14 NA NA NA hsa-miR-181c-5p ERBB4 0.287567602280886 0.587379107531716 -5.37185314288958 2.30708721608433e-25 mirMAP -0.289676559563634 0.00533793038355396 NA NA NA hsa-miR-193a-3p ERBB4 0.183521555169311 0.61877899263343 -5.37185314288958 2.30708721608433e-25 MirTarget;miRNATAP -0.339753224504527 0.00167919418348717 25391651;26655272 miR 193a 3p functions as a tumor suppressor in lung cancer by down regulating ERBB4; We identified specific targeting sites for miR-193a-3p in the 3'-UTR of ERBB4; We further identified an inverse correlation between miR-193a-3p levels and ERBB4 protein levels but not mRNA levels in lung cancer tissue samples; By overexpressing or knocking down miR-193a-3p in lung cancer cells we experimentally confirmed that miR-193a-3p directly recognizes the 3'-UTR of the ERBB4 transcript and regulates ERBB4 expression; Furthermore the biological consequences of the targeting of ERBB4 by miR-193a-3p were examined in vitro via cell proliferation invasion and apoptosis assays and in vivo using a mouse xenograft tumor model; We demonstrated that the repression of ERBB4 by miR-193a-3p suppressed proliferation and invasion and promoted apoptosis in lung cancer cells and that miR-193a-3p exerted an anti-tumor effect by negatively regulating ERBB4 in xenograft mice; Taken together our findings provide the first clues regarding the role of miR-193a-3p as a tumor suppressor in lung cancer through the inhibition of ERBB4 translation;Moreover mechanistic investigations showed that UCA1 upregulated the expression of miR-193a-3p target gene ERBB4 through competitively 'spongeing' miR-193a-3p; Overall we concluded that UCA1 functions as an oncogene in NSCLC acting mechanistically by upregulating ERBB4 in part through 'spongeing' miR-193a-3p ; lung cancer;lung squamous cell cancer hsa-miR-194-5p ERBB4 0.121400158256988 0.856838184584703 -5.37185314288958 2.30708721608433e-25 miRNATAP -0.275670223439778 0.0415000023578523 NA NA NA hsa-miR-19a-3p ERBB4 1.46790979235261 0.000361171910570302 -5.37185314288958 2.30708721608433e-25 miRNAWalker2_validate;miRTarBase;miRNATAP -1.00394812037635 3.31202849940887e-40 NA NA NA hsa-miR-19b-3p ERBB4 1.16012277183793 0.0628519598637838 -5.37185314288958 2.30708721608433e-25 miRNATAP -0.973773798408 7.97568425587549e-25 NA NA NA hsa-miR-221-3p ERBB4 0.889236679257595 0.165212011318271 -5.37185314288958 2.30708721608433e-25 miRNATAP -1.13719282418678 7.18552772010395e-34 NA NA NA hsa-miR-222-3p ERBB4 1.01165425875596 0.0347025183740878 -5.37185314288958 2.30708721608433e-25 miRNATAP -0.959765974462763 8.8889321634283e-28 NA NA NA hsa-miR-23a-3p ERBB4 0.598077839924402 0.563738070978 -5.37185314288958 2.30708721608433e-25 miRNATAP -1.31606560247383 3.40764391922014e-21 NA NA NA hsa-miR-23b-3p ERBB4 0.325018208255861 0.697275325712378 -5.37185314288958 2.30708721608433e-25 miRNATAP -0.477988421608263 6.13999685736269e-05 NA NA NA hsa-miR-27a-5p ERBB4 0.402508736270478 0.292340622595247 -5.37185314288958 2.30708721608433e-25 miRNATAP -0.218143555211365 0.0104670001462383 NA NA NA hsa-miR-301a-3p ERBB4 0.968506401137921 0.000570564850124159 -5.37185314288958 2.30708721608433e-25 miRNATAP -0.628226881417503 9.72331311229569e-20 NA NA NA hsa-miR-30e-5p ERBB4 0.74013844669909 0.511970582859704 -5.37185314288958 2.30708721608433e-25 mirMAP -1.20913744423238 1.81916316325587e-17 NA NA NA hsa-miR-330-3p ERBB4 0.537733996157442 0.00592119172883149 -5.37185314288958 2.30708721608433e-25 MirTarget;PITA;miRNATAP -0.320702537200979 0.00109448229099187 NA NA NA hsa-miR-330-5p ERBB4 0.563423954500856 0.194785172695321 -5.37185314288958 2.30708721608433e-25 miRNATAP -0.71083230091054 1.25321486544143e-10 NA NA NA hsa-miR-361-5p ERBB4 0.295581181703002 0.679805903809273 -5.37185314288958 2.30708721608433e-25 miRanda;mirMAP -1.22825146131928 9.17158724791728e-10 NA NA NA hsa-miR-362-5p ERBB4 0.820801646347614 0.0107637300891325 -5.37185314288958 2.30708721608433e-25 PITA;TargetScan;miRNATAP -0.979727308009705 2.12109407947267e-32 NA NA NA hsa-miR-374a-3p ERBB4 0.47806575213705 0.580820043553098 -5.37185314288958 2.30708721608433e-25 MirTarget;mirMAP;miRNATAP -0.817893780229992 2.70946684003894e-08 NA NA NA hsa-miR-374a-5p ERBB4 0.47302975636239 0.309552532909276 -5.37185314288958 2.30708721608433e-25 mirMAP -0.85356650445241 5.70142966899516e-09 NA NA NA hsa-miR-374b-5p ERBB4 0.478896841162915 0.365769179152496 -5.37185314288958 2.30708721608433e-25 mirMAP -0.809343968543253 1.97057096645665e-08 NA NA NA hsa-miR-429 ERBB4 0.448029985835258 0.437184735816941 -5.37185314288958 2.30708721608433e-25 PITA;miRanda;miRNATAP -0.132997468006583 0.0431936949788559 NA NA NA hsa-miR-452-5p ERBB4 2.0200941872388 0.000263136484394316 -5.37185314288958 2.30708721608433e-25 mirMAP -0.701884213446386 2.37990608843616e-40 NA NA NA hsa-miR-454-3p ERBB4 0.427403467632791 0.11673336658399 -5.37185314288958 2.30708721608433e-25 miRNATAP -0.425433484838218 5.68728902265879e-07 NA NA NA hsa-miR-455-5p ERBB4 1.38138264178539 0.00151082519157593 -5.37185314288958 2.30708721608433e-25 miRNATAP -1.25797618830575 9.36949278569158e-53 NA NA NA hsa-miR-485-3p ERBB4 0.0755008543866269 0.751124972921196 -5.37185314288958 2.30708721608433e-25 mirMAP -0.190407068961608 0.0352512487476173 NA NA NA hsa-miR-576-5p ERBB4 1.29396616748627 4.70941163094532e-05 -5.37185314288958 2.30708721608433e-25 PITA -1.03921764612909 3.25130186720161e-27 NA NA NA hsa-miR-584-5p ERBB4 1.80180408018088 0.000553101190349556 -5.37185314288958 2.30708721608433e-25 mirMAP -1.04946332355711 1.06807000086008e-45 NA NA NA hsa-miR-589-3p ERBB4 0.869015836905941 1.30925035072401e-06 -5.37185314288958 2.30708721608433e-25 mirMAP -0.636388285183413 7.27685924015814e-17 NA NA NA hsa-miR-589-5p ERBB4 0.230201267274126 0.668365586561059 -5.37185314288958 2.30708721608433e-25 miRNATAP -1.17606441834772 9.32804865258599e-18 NA NA NA hsa-miR-590-3p ERBB4 1.01238246880436 6.25794947126089e-07 -5.37185314288958 2.30708721608433e-25 miRanda;mirMAP -0.937739257163784 4.90281349296452e-24 NA NA NA hsa-miR-660-5p ERBB4 0.789334042528136 0.108629249007974 -5.37185314288958 2.30708721608433e-25 mirMAP;miRNATAP -1.52542779983287 1.21158852836455e-48 NA NA NA hsa-let-7f-1-3p ESR1 0.541305090676599 0.000810726288280833 -6.14976130956365 3.35739499466122e-17 mirMAP -0.596241706169458 3.20952205563396e-09 NA NA NA hsa-miR-107 ESR1 0.351433472692356 0.523819413335979 -6.14976130956365 3.35739499466122e-17 PITA;miRanda;miRNATAP -0.52080715961539 0.000233342922472232 26033453 Estrogen-receptor negative tumors displayed higher concentrations of circulating miR-107 than their counterparts p = 0.035; However overexpression of miR-107 in MCF-7 cells did not downregulate estrogen receptor protein breast cancer hsa-miR-125b-2-3p ESR1 0.295384471337631 0.494858321261013 -6.14976130956365 3.35739499466122e-17 mirMAP -0.483275866876461 1.62125592433327e-10 NA NA NA hsa-miR-130a-3p ESR1 0.849038376258018 0.133664106340641 -6.14976130956365 3.35739499466122e-17 miRNAWalker2_validate;miRTarBase;miRNATAP -0.706399613843885 1.37851433639071e-15 NA NA NA hsa-miR-130b-3p ESR1 1.16970507422762 6.85086072809354e-05 -6.14976130956365 3.35739499466122e-17 miRNATAP -1.01925027311659 4.1467527319139e-32 NA NA NA hsa-miR-130b-5p ESR1 1.3947936173305 4.50465898911354e-07 -6.14976130956365 3.35739499466122e-17 mirMAP -0.791486008201584 8.6427467329093e-26 NA NA NA hsa-miR-132-3p ESR1 0.240816226207972 0.678532290124258 -6.14976130956365 3.35739499466122e-17 mirMAP -0.720879577095591 2.43271021786454e-07 NA NA NA hsa-miR-146b-3p ESR1 0.782739700761217 0.193808343781228 -6.14976130956365 3.35739499466122e-17 miRNATAP -1.1068135719937 1.72302453294009e-27 NA NA NA hsa-miR-148a-3p ESR1 0.722527444447689 0.597269550476641 -6.14976130956365 3.35739499466122e-17 miRNATAP -0.543683433433829 1.85634766952e-08 25063027 miR-148a plays an important role in regulation of cancer cell proliferation and cancer invasion and down-regulation of miR-148a has been reported in both estrogen receptor ER positive and triple-negative TN breast cancer breast cancer hsa-miR-17-5p ESR1 1.80801649919324 0.017740816345401 -6.14976130956365 3.35739499466122e-17 TargetScan -1.19544166824122 3.22289120464407e-48 NA NA NA hsa-miR-181a-5p ESR1 0.206424802853514 0.833057626260378 -6.14976130956365 3.35739499466122e-17 miRNATAP -0.642051980641508 9.70999220835469e-08 NA NA NA hsa-miR-181b-5p ESR1 0.515446560070718 0.50566125221377 -6.14976130956365 3.35739499466122e-17 miRNATAP -0.755926645065685 6.52391349261287e-14 NA NA NA hsa-miR-181c-5p ESR1 0.287567602280886 0.587379107531716 -6.14976130956365 3.35739499466122e-17 miRNATAP -0.26630626006218 0.0104222586041951 NA NA NA hsa-miR-186-5p ESR1 1.04333228080691 0.148711371364268 -6.14976130956365 3.35739499466122e-17 mirMAP -1.40338420717257 1.311041694549e-32 NA NA NA hsa-miR-18a-5p ESR1 2.29585803678176 4.13931899001596e-14 -6.14976130956365 3.35739499466122e-17 miRNAWalker2_validate;miRTarBase;miRNATAP -1.14044745041939 3.5647791599912e-74 19027010;24975878 MicroRNA 18a prevents estrogen receptor alpha expression promoting proliferation of hepatocellular carcinoma cells; The gene ESR1 which encodes the estrogen receptor-alpha ERalpha was identified as a target of miR-18a miR-18a can repress ERalpha translation by binding to its mRNA at the 3' untranslated region;Elevated p53 promotes the processing of miR 18a to decrease estrogen receptor α in female hepatocellular carcinoma; Our previous study identified that estrogen receptor alpha ERα protein is downregulated in 60% of female HCC cases via a miR-18a elevation mediated suppression of ERα translation ; liver cancer;liver cancer hsa-miR-19a-3p ESR1 1.46790979235261 0.000361171910570302 -6.14976130956365 3.35739499466122e-17 miRNAWalker2_validate;miRTarBase;miRNATAP -0.918018971888875 2.34175436155262e-33 26416600 We speculate that miR-19a might be co-expressed with lncRNA-DLEU1 to co-regulate the expression of ESR1 which influences the occurrence and development of breast cancer cells with different levels of ER expression breast cancer hsa-miR-19b-3p ESR1 1.16012277183793 0.0628519598637838 -6.14976130956365 3.35739499466122e-17 miRNAWalker2_validate;miRTarBase;miRNATAP -0.955532284971413 6.21638783917986e-24 NA NA NA hsa-miR-20b-5p ESR1 0.530665078264877 0.214523921293588 -6.14976130956365 3.35739499466122e-17 miRNAWalker2_validate;miRTarBase -0.145222488631583 0.0144616347030701 NA NA NA hsa-miR-21-3p ESR1 0.115900341574742 0.904443786801208 -6.14976130956365 3.35739499466122e-17 mirMAP -0.31824892123099 0.000480950639571142 19264808;25337203;21131358;25969534 miR-21 is higher in ER alpha positive than negative tumors but no one has examined how estradiol E2 regulates miR-21 in breast cancer cells; The E2-induced reduction in miR-21 was inhibited by 4-hydroxytamoxifen 4-OHT ICI 182 780 Faslodex and siRNA ER alpha indicating that the suppression is ER alpha-mediated; ER alpha and ER beta agonists PPT and DPN inhibited and 4-OHT increased miR-21 expression; These results are the first to demonstrate that E2 represses the expression of an oncogenic miRNA miR-21 by activating estrogen receptor in MCF-7 cells;Odds ratios ORs showed that miR-21 expression was closely associated with estrogen receptor ER progesterone receptor PR lymph node metastasis histological grade Her2/neu;Induction of miR 21 by retinoic acid in estrogen receptor positive breast carcinoma cells: biological correlates and molecular targets;Dehydroepiandrosterone Activation of G protein coupled Estrogen Receptor Rapidly Stimulates MicroRNA 21 Transcription in Human Hepatocellular Carcinoma Cells ;metastasis;; breast cancer;breast cancer;breast cancer;liver cancer hsa-miR-212-3p ESR1 0.733470062196833 0.0007562475324171 -6.14976130956365 3.35739499466122e-17 mirMAP -0.788572914463833 4.10000727664385e-17 NA NA NA hsa-miR-217 ESR1 0.468063318648715 0.245270563056356 -6.14976130956365 3.35739499466122e-17 miRanda -0.310750459089371 3.62474341001295e-05 NA NA NA hsa-miR-22-3p ESR1 0.0490135867272876 0.973443437320593 -6.14976130956365 3.35739499466122e-17 miRNAWalker2_validate;miRTarBase;miRNATAP -0.973519657734076 1.26054178882888e-08 20180843;24715036 An estrogen receptor alpha suppressor microRNA 22 is downregulated in estrogen receptor alpha positive human breast cancer cell lines and clinical samples;miR 22 inhibits proliferation and invasion in estrogen receptor α positive endometrial endometrioid carcinomas cells ; breast cancer;endometrial cancer hsa-miR-221-3p ESR1 0.889236679257595 0.165212011318271 -6.14976130956365 3.35739499466122e-17 miRNAWalker2_validate;miRNATAP -1.00581969887263 2.15975574415267e-26 25483016 HBx protein induced upregulation of microRNA 221 promotes aberrant proliferation in HBV‑related hepatocellular carcinoma by targeting estrogen receptor α liver cancer hsa-miR-222-3p ESR1 1.01165425875596 0.0347025183740878 -6.14976130956365 3.35739499466122e-17 miRNAWalker2_validate;miRNATAP -0.830321095773127 7.33101503145802e-21 NA NA NA hsa-miR-29a-5p ESR1 0.800121562512528 0.00103825219976412 -6.14976130956365 3.35739499466122e-17 mirMAP -0.571044888801489 1.46744006558388e-08 21761362 MiR-222/221 which target ESR1 itself and miR-29a are predicted to target the 3' UTR of Dicer1 breast cancer hsa-miR-301a-3p ESR1 0.968506401137921 0.000570564850124159 -6.14976130956365 3.35739499466122e-17 miRNATAP -0.4879131572964 2.64298055602113e-12 NA NA NA hsa-miR-30e-3p ESR1 0.529604563002 0.641658069028144 -6.14976130956365 3.35739499466122e-17 mirMAP -0.753498152824586 2.85377943758404e-06 NA NA NA hsa-miR-320b ESR1 0.712468682578545 0.00260489977004221 -6.14976130956365 3.35739499466122e-17 PITA;mirMAP -0.40093763379491 1.94618105456694e-05 NA NA NA hsa-miR-324-5p ESR1 1.05212162375636 0.00665123910009839 -6.14976130956365 3.35739499466122e-17 PITA -0.624966417762192 2.33211335642968e-14 NA NA NA hsa-miR-330-3p ESR1 0.537733996157442 0.00592119172883149 -6.14976130956365 3.35739499466122e-17 PITA;mirMAP;miRNATAP -0.228825753894928 0.0199551204210749 NA NA NA hsa-miR-361-5p ESR1 0.295581181703002 0.679805903809273 -6.14976130956365 3.35739499466122e-17 miRNATAP -1.09655592249789 4.84366481208876e-08 NA NA NA hsa-miR-374a-3p ESR1 0.47806575213705 0.580820043553098 -6.14976130956365 3.35739499466122e-17 miRNATAP -1.23188723310908 2.28097851123598e-17 NA NA NA hsa-miR-374a-5p ESR1 0.47302975636239 0.309552532909276 -6.14976130956365 3.35739499466122e-17 mirMAP -1.37625560102013 1.22284318507823e-21 NA NA NA hsa-miR-374b-5p ESR1 0.478896841162915 0.365769179152496 -6.14976130956365 3.35739499466122e-17 mirMAP -1.26207513301612 6.57262817753244e-19 NA NA NA hsa-miR-409-3p ESR1 -0.194297569191983 0.630520748307576 -6.14976130956365 3.35739499466122e-17 mirMAP -0.262209139504514 0.00928458513174569 NA NA NA hsa-miR-450b-5p ESR1 0.191777880666372 0.614703205288598 -6.14976130956365 3.35739499466122e-17 mirMAP;miRNATAP -0.305683223774132 0.00211979139713611 NA NA NA hsa-miR-454-3p ESR1 0.427403467632791 0.11673336658399 -6.14976130956365 3.35739499466122e-17 miRNATAP -0.280950924792971 0.000999084364001009 NA NA NA hsa-miR-455-5p ESR1 1.38138264178539 0.00151082519157593 -6.14976130956365 3.35739499466122e-17 miRanda -1.08611399370055 2.05209360291252e-38 NA NA NA hsa-miR-589-3p ESR1 0.869015836905941 1.30925035072401e-06 -6.14976130956365 3.35739499466122e-17 mirMAP -0.64455536100727 2.7086347347523e-17 NA NA NA hsa-miR-590-3p ESR1 1.01238246880436 6.25794947126089e-07 -6.14976130956365 3.35739499466122e-17 miRanda;mirMAP;miRNATAP -0.88040206816541 2.9880939993017e-21 NA NA NA hsa-miR-660-5p ESR1 0.789334042528136 0.108629249007974 -6.14976130956365 3.35739499466122e-17 miRNATAP -1.24125009028228 1.87735356236176e-31 NA NA NA hsa-miR-9-5p ESR1 2.31356623051719 0.0110746694972708 -6.14976130956365 3.35739499466122e-17 mirMAP;miRNATAP -0.571692276785571 1.09806234668515e-34 22723919 Higher expression of miR-9 was significantly associated with breast cancer LR in all cases as well as the subset of estrogen receptor ER positive cases p = 0.02 breast cancer hsa-miR-342-3p FABP7 -0.720941204737844 0.328091715069398 5.47288169257402 1.78690178960361e-25 miRanda -1.05685928900075 8.2597488891093e-21 NA NA NA hsa-miR-106a-5p FOXA1 1.15783699791289 0.000894643692244881 -5.31808157442115 1.98828415101881e-14 miRNATAP -0.385843556791436 1.76537847172726e-07 NA NA NA hsa-miR-106b-5p FOXA1 1.04856358809711 0.139094273282727 -5.31808157442115 1.98828415101881e-14 miRNATAP -0.944172766459456 3.93598957330965e-20 NA NA NA hsa-miR-132-3p FOXA1 0.240816226207972 0.678532290124258 -5.31808157442115 1.98828415101881e-14 miRNATAP -0.746233393794386 1.63927032085846e-08 NA NA NA hsa-miR-142-5p FOXA1 1.23477289272799 0.0150054709615798 -5.31808157442115 1.98828415101881e-14 PITA -0.471213000056357 1.01917056332025e-11 NA NA NA hsa-miR-17-5p FOXA1 1.80801649919324 0.017740816345401 -5.31808157442115 1.98828415101881e-14 TargetScan;miRNATAP -1.15847706339726 1.3067330765741e-50 NA NA NA hsa-miR-20a-5p FOXA1 1.44423592705205 0.0465200458169632 -5.31808157442115 1.98828415101881e-14 miRNATAP -1.12253379358824 2.99322905265919e-43 NA NA NA hsa-miR-212-3p FOXA1 0.733470062196833 0.0007562475324171 -5.31808157442115 1.98828415101881e-14 miRNATAP -0.601913804723841 1.80383487494492e-11 25965836 MicroRNA 212 suppresses tumor growth of human hepatocellular carcinoma by targeting FOXA1; Furthermore we confirmed that Forkhead box protein A1 FOXA1 was a direct target of miR-212 and it abrogated the function of miR-212 in HCC; Finally we disclosed that the aberrant expression of miR-212 and FOXA1 was evidently correlated with poor prognostic features of HCC; MiR-212 FOXA1 and their combination were valuable prognostic markers for predicting survival of HCC patients; In conclusion miR-212 may serve as a prognostic indicator for HCC patients and exerts tumor suppressive role at least in part by inhibiting FOXA1 poor survival liver cancer hsa-miR-215-5p FOXA1 0.469167912455808 0.0652445033370017 -5.31808157442115 1.98828415101881e-14 miRNAWalker2_validate -0.533780504637524 6.52434521730905e-13 NA NA NA hsa-miR-30c-5p FOXA1 0.2904764284977 0.738803502565399 -5.31808157442115 1.98828415101881e-14 miRNATAP -0.327794175230813 0.0037276871282263 NA NA NA hsa-miR-30d-5p FOXA1 0.171445446354708 0.882863964947721 -5.31808157442115 1.98828415101881e-14 miRNATAP -0.432999430445767 0.000999464332947312 NA NA NA hsa-miR-361-5p FOXA1 0.295581181703002 0.679805903809273 -5.31808157442115 1.98828415101881e-14 miRanda -1.43075098653569 3.68312459600593e-14 NA NA NA hsa-miR-590-3p FOXA1 1.01238246880436 6.25794947126089e-07 -5.31808157442115 1.98828415101881e-14 PITA;miRanda;miRNATAP -0.6536546932847 2.22588587624367e-13 NA NA NA hsa-miR-93-5p FOXA1 0.943892623097563 0.3984984603332 -5.31808157442115 1.98828415101881e-14 miRNATAP -0.92086173758913 8.8226785199728e-20 NA NA NA hsa-miR-126-5p FSIP1 -0.00481947073974087 0.994552231964025 -5.05591218986468 5.72461141548286e-40 MirTarget -0.219884478490187 0.0194898727396223 NA NA NA hsa-miR-181a-2-3p FSIP1 0.682351266467006 0.429599916993576 -5.05591218986468 5.72461141548286e-40 MirTarget -1.00621483666019 5.55225557707112e-17 NA NA NA hsa-miR-181a-5p FSIP1 0.206424802853514 0.833057626260378 -5.05591218986468 5.72461141548286e-40 miRNAWalker2_validate -0.306399187805498 0.0057318169579902 NA NA NA hsa-miR-27a-3p FSIP1 0.628895559781173 0.490244908291708 -5.05591218986468 5.72461141548286e-40 MirTarget -1.03054683485575 5.9099534658692e-18 NA NA NA hsa-miR-27b-3p FSIP1 0.31299864801146 0.712470214220383 -5.05591218986468 5.72461141548286e-40 MirTarget -0.757515753017577 1.20690498716559e-11 NA NA NA hsa-miR-590-3p FSIP1 1.01238246880436 6.25794947126089e-07 -5.05591218986468 5.72461141548286e-40 MirTarget;miRanda -0.628029067182505 2.95034886837019e-13 NA NA NA hsa-miR-125a-3p GP2 0.179529841024673 0.416182564332207 -6.62758123990808 6.33600952829015e-34 miRanda -0.785022484413352 2.82181265569315e-07 NA NA NA hsa-miR-29a-5p GP2 0.800121562512528 0.00103825219976412 -6.62758123990808 6.33600952829015e-34 mirMAP -1.01082739810653 3.06483168989559e-13 NA NA NA hsa-miR-195-3p HORMAD1 -0.148955193954253 0.573960981017585 5.42807554527017 6.60693107003248e-23 MirTarget -0.265545669344493 0.0176707956572481 NA NA NA hsa-miR-29c-3p HORMAD1 -0.643278710106618 0.522845109493165 5.42807554527017 6.60693107003248e-23 MirTarget -0.761310098562063 6.28227079832183e-11 NA NA NA hsa-let-7d-5p KCNJ3 0.737311896446371 0.277996131668254 -5.96284069565866 9.41479220126037e-26 miRNATAP -0.511905282012612 0.00647774756846278 NA NA NA hsa-let-7i-5p KCNJ3 0.491983487993952 0.539800598932235 -5.96284069565866 9.41479220126037e-26 miRNATAP -2.35153125380886 3.73332858691052e-17 NA NA NA hsa-miR-140-5p KCNJ3 0.781948085004431 0.101152958138705 -5.96284069565866 9.41479220126037e-26 miRanda -0.725191554383511 1.19782718296441e-05 NA NA NA hsa-miR-142-5p KCNJ3 1.23477289272799 0.0150054709615798 -5.96284069565866 9.41479220126037e-26 PITA;mirMAP;miRNATAP -0.568400819786477 7.02783300455738e-08 NA NA NA hsa-miR-154-5p KCNJ3 -0.146157771589802 0.547418947692758 -5.96284069565866 9.41479220126037e-26 mirMAP -0.254655176040475 0.0278787378776554 NA NA NA hsa-miR-199b-5p KCNJ3 -0.489883928472198 0.514360594242384 -5.96284069565866 9.41479220126037e-26 miRanda -0.254896813794878 0.0466741878264066 NA NA NA hsa-miR-25-3p KCNJ3 0.734786337660527 0.544331320304672 -5.96284069565866 9.41479220126037e-26 miRNATAP -1.30860737040788 2.44513068983087e-09 NA NA NA hsa-miR-27a-3p KCNJ3 0.628895559781173 0.490244908291708 -5.96284069565866 9.41479220126037e-26 miRNATAP -1.34815886313708 8.6100090005687e-13 NA NA NA hsa-miR-27b-3p KCNJ3 0.31299864801146 0.712470214220383 -5.96284069565866 9.41479220126037e-26 miRNATAP -1.06422526774286 1.40699141473909e-09 NA NA NA hsa-miR-32-5p KCNJ3 0.531860098119996 0.195500436097555 -5.96284069565866 9.41479220126037e-26 miRNATAP -0.307947841026663 0.033338193758541 NA NA NA hsa-miR-361-5p KCNJ3 0.295581181703002 0.679805903809273 -5.96284069565866 9.41479220126037e-26 MirTarget;PITA;miRanda -0.993792577125429 0.000613351962798975 NA NA NA hsa-miR-369-3p KCNJ3 -0.147594099352296 0.572262502832966 -5.96284069565866 9.41479220126037e-26 PITA;miRNATAP -0.675815319269046 6.25779491907507e-07 NA NA NA hsa-miR-374a-3p KCNJ3 0.47806575213705 0.580820043553098 -5.96284069565866 9.41479220126037e-26 MirTarget;miRNATAP -0.900349287031127 2.16156621745815e-05 NA NA NA hsa-miR-500a-3p KCNJ3 0.819125859525888 0.245855065392962 -5.96284069565866 9.41479220126037e-26 MirTarget;miRNATAP -1.08168593013236 1.74775437715754e-11 NA NA NA hsa-miR-542-3p KCNJ3 0.0492894440657814 0.946714392793758 -5.96284069565866 9.41479220126037e-26 miRNATAP -0.3649873425621 0.0131676487658412 NA NA NA hsa-miR-590-3p KCNJ3 1.01238246880436 6.25794947126089e-07 -5.96284069565866 9.41479220126037e-26 PITA;miRanda;mirMAP;miRNATAP -0.520189519853608 0.000139568460954844 NA NA NA hsa-miR-590-5p KCNJ3 1.40236682288609 3.89322108176281e-06 -5.96284069565866 9.41479220126037e-26 miRanda -0.701344608631069 6.77506053510114e-08 NA NA NA hsa-miR-92a-3p KCNJ3 1.22719477478376 0.303128344063904 -5.96284069565866 9.41479220126037e-26 miRNATAP -1.21275816412832 3.12756098037022e-13 NA NA NA hsa-miR-335-5p MSLN 0.0404259244994374 0.914858946651589 5.52454165237846 7.28662202365893e-35 miRNAWalker2_validate -0.380271967627019 3.63130739505661e-07 NA NA NA hsa-miR-222-5p NR2E3 1.06875698293133 5.60304006597586e-07 -6.70487940088293 8.32556831816011e-18 MirTarget -0.621263843095637 2.1507007523436e-08 NA NA NA hsa-miR-30e-3p NR2E3 0.529604563002 0.641658069028144 -6.70487940088293 8.32556831816011e-18 MirTarget -0.465483961597252 0.0311019574977157 NA NA NA hsa-miR-320b NR2E3 0.712468682578545 0.00260489977004221 -6.70487940088293 8.32556831816011e-18 MirTarget;miRanda -0.378578550249145 0.00258203006911546 NA NA NA hsa-miR-330-5p NR2E3 0.563423954500856 0.194785172695321 -6.70487940088293 8.32556831816011e-18 miRanda -0.389139138038554 0.00896959900274092 NA NA NA hsa-miR-339-5p NR2E3 0.176562373115907 0.71435382230926 -6.70487940088293 8.32556831816011e-18 miRanda -0.301076956794125 0.0279864225805859 NA NA NA hsa-miR-590-3p NR2E3 1.01238246880436 6.25794947126089e-07 -6.70487940088293 8.32556831816011e-18 miRanda -0.689275676392869 4.8962742358497e-08 NA NA NA hsa-miR-744-3p NR2E3 1.09581769881374 0.000780540070736859 -6.70487940088293 8.32556831816011e-18 MirTarget -0.443981137906928 1.35683857572033e-06 NA NA NA hsa-miR-7-1-3p ROPN1 -0.136535237676745 0.726879891153832 5.62561186746942 3.41963311786961e-39 mirMAP -0.48070849962043 3.33470597650071e-06 NA NA NA hsa-miR-140-5p SCGB2A2 0.781948085004431 0.101152958138705 -5.72332006473316 3.72546940561696e-12 miRanda -0.788650513063007 4.11448611003728e-05 NA NA NA hsa-miR-142-3p SCGB2A2 1.18219258029821 0.19611934127025 -5.72332006473316 3.72546940561696e-12 miRanda -0.545310044444354 2.96326121933926e-07 NA NA NA hsa-miR-125a-3p SLC44A4 0.179529841024673 0.416182564332207 -5.4062896003385 1.48241445123023e-19 miRanda -0.552722068978654 3.76486212514117e-07 NA NA NA hsa-miR-140-3p SLC44A4 0.562212100226517 0.538115971474499 -5.4062896003385 1.48241445123023e-19 miRNATAP -0.741788421059368 2.50334912535851e-12 NA NA NA hsa-miR-107 SYT9 0.351433472692356 0.523819413335979 -5.13581876043077 9.35231030651764e-32 miRanda -0.592336548691308 0.000176846521294597 NA NA NA hsa-miR-142-3p SYT9 1.18219258029821 0.19611934127025 -5.13581876043077 9.35231030651764e-32 miRanda -0.485458396199416 7.27435783550917e-12 NA NA NA hsa-miR-146b-5p SYT9 0.876334790841257 0.284935762703604 -5.13581876043077 9.35231030651764e-32 miRanda -0.888098462618609 1.52831318118446e-15 NA NA NA hsa-miR-192-5p SYT9 0.471716293688646 0.531156230462861 -5.13581876043077 9.35231030651764e-32 mirMAP -0.471624190190852 9.87036954315356e-06 NA NA NA hsa-miR-193a-3p SYT9 0.183521555169311 0.61877899263343 -5.13581876043077 9.35231030651764e-32 miRanda -0.699515775241176 5.24084665321133e-09 NA NA NA hsa-miR-196b-5p SYT9 0.503678894705795 0.45545062984404 -5.13581876043077 9.35231030651764e-32 MirTarget -0.395493908865485 1.64509071000021e-07 NA NA NA hsa-miR-29a-3p SYT9 0.46338784979134 0.683743087347155 -5.13581876043077 9.35231030651764e-32 miRNATAP -0.493157807302895 0.000394961993486084 NA NA NA hsa-miR-29b-3p SYT9 0.271083597599281 0.740286663164405 -5.13581876043077 9.35231030651764e-32 miRNATAP -0.451252177172674 0.00018001711372706 NA NA NA hsa-miR-30b-3p SYT9 0.353268230055879 0.0503719815958775 -5.13581876043077 9.35231030651764e-32 MirTarget -0.468675562554171 7.11992631369479e-06 NA NA NA hsa-miR-320b SYT9 0.712468682578545 0.00260489977004221 -5.13581876043077 9.35231030651764e-32 miRanda -0.463416809920917 9.6821930612019e-06 NA NA NA hsa-miR-324-5p SYT9 1.05212162375636 0.00665123910009839 -5.13581876043077 9.35231030651764e-32 miRanda -0.853392890563215 4.59307501678964e-21 NA NA NA hsa-miR-326 SYT9 0.215485710119405 0.487218662995766 -5.13581876043077 9.35231030651764e-32 MirTarget;PITA;miRanda;miRNATAP -0.162149550387017 0.0247626829083362 NA NA NA hsa-miR-330-5p SYT9 0.563423954500856 0.194785172695321 -5.13581876043077 9.35231030651764e-32 MirTarget;PITA;miRanda;miRNATAP -0.597836450101949 1.41170640055706e-06 NA NA NA hsa-miR-331-5p SYT9 0.399733586480102 0.0121010815563507 -5.13581876043077 9.35231030651764e-32 PITA;miRNATAP -0.566912574174871 8.37409790135952e-06 NA NA NA hsa-miR-374a-5p SYT9 0.47302975636239 0.309552532909276 -5.13581876043077 9.35231030651764e-32 mirMAP -0.856238529243804 1.71958349537697e-07 NA NA NA hsa-miR-374b-5p SYT9 0.478896841162915 0.365769179152496 -5.13581876043077 9.35231030651764e-32 mirMAP -1.0394838641181 8.97612821886717e-11 NA NA NA hsa-miR-455-5p SYT9 1.38138264178539 0.00151082519157593 -5.13581876043077 9.35231030651764e-32 miRanda -0.873414306955424 8.19520974200567e-20 NA NA NA hsa-miR-671-5p SYT9 0.834434167250404 7.38955042149834e-05 -5.13581876043077 9.35231030651764e-32 MirTarget -0.799833621349481 4.07398985861183e-16 NA NA NA hsa-miR-9-5p SYT9 2.31356623051719 0.0110746694972708 -5.13581876043077 9.35231030651764e-32 miRNATAP -0.523248272260402 3.37311841899627e-23 NA NA NA hsa-miR-125a-3p SYTL5 0.179529841024673 0.416182564332207 -5.13983220649863 5.16588432345796e-37 MirTarget;miRanda;miRNATAP -0.318101367551174 0.00380471285061759 NA NA NA hsa-miR-144-5p SYTL5 0.193779998748036 0.72991328591606 -5.13983220649863 5.16588432345796e-37 mirMAP -0.118734860672777 0.0473012773649839 NA NA NA hsa-miR-185-3p SYTL5 1.02296406566789 2.42658505261776e-06 -5.13983220649863 5.16588432345796e-37 MirTarget -0.615419892444937 1.16360281928497e-13 NA NA NA hsa-miR-217 SYTL5 0.468063318648715 0.245270563056356 -5.13983220649863 5.16588432345796e-37 miRanda -0.221976547585613 0.00294343676861466 NA NA NA hsa-miR-29a-5p SYTL5 0.800121562512528 0.00103825219976412 -5.13983220649863 5.16588432345796e-37 MirTarget -0.594312120653781 2.47308980437656e-09 NA NA NA hsa-miR-339-5p SYTL5 0.176562373115907 0.71435382230926 -5.13983220649863 5.16588432345796e-37 miRanda -0.210543206159794 0.0382873148775393 NA NA NA hsa-miR-576-5p SYTL5 1.29396616748627 4.70941163094532e-05 -5.13983220649863 5.16588432345796e-37 mirMAP -0.974084443302519 1.97839605193194e-24 NA NA NA hsa-miR-590-3p SYTL5 1.01238246880436 6.25794947126089e-07 -5.13983220649863 5.16588432345796e-37 mirMAP -0.774700112073354 5.99725477103059e-17 NA NA NA hsa-miR-590-5p SYTL5 1.40236682288609 3.89322108176281e-06 -5.13983220649863 5.16588432345796e-37 miRanda -0.917035775617969 1.03431740003804e-25 NA NA NA hsa-miR-326 TFF1 0.215485710119405 0.487218662995766 -8.49013584563704 1.53209724456077e-34 miRanda -0.307223389114311 0.00258934712955116 NA NA NA hsa-miR-330-5p TFF1 0.563423954500856 0.194785172695321 -8.49013584563704 1.53209724456077e-34 miRanda -0.873292788372431 6.14785804388824e-07 NA NA NA hsa-miR-590-3p TFF1 1.01238246880436 6.25794947126089e-07 -8.49013584563704 1.53209724456077e-34 miRanda -1.20093974336874 4.49067318867514e-16 NA NA NA hsa-miR-1301-3p TFF3 1.13236779080729 0.00035660210335027 -7.19357895218681 6.85570486505245e-26 MirTarget -0.630724103782286 1.5285053590182e-11 NA NA NA hsa-miR-320a TFF3 0.241225090812918 0.773692094298861 -7.19357895218681 6.85570486505245e-26 miRanda -0.340100176526261 0.0316004336193192 NA NA NA hsa-miR-320b TFF3 0.712468682578545 0.00260489977004221 -7.19357895218681 6.85570486505245e-26 miRanda -0.691220912463874 5.78171437983842e-10 NA NA NA