miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106a-5p AKT3 -0.203919267842652 0.802213958426804 0.457269233600447 0.539326812115034 miRNATAP -0.549479065869633 4.88994896864722e-11 NA NA NA hsa-miR-106b-5p AKT3 -0.297128724729339 0.869294443540749 0.457269233600447 0.539326812115034 miRNATAP -0.910251258276316 1.51432008761514e-23 NA NA NA hsa-miR-107 AKT3 -0.0365118169251648 0.988364120226869 0.457269233600447 0.539326812115034 PITA;miRanda -0.551086378595188 0.000172037624489873 NA NA NA hsa-miR-1275 AKT3 -0.831342050607648 0.0803795852164229 0.457269233600447 0.539326812115034 PITA -0.265795172887599 9.47325565176386e-07 NA NA NA hsa-miR-142-3p AKT3 -0.154235241441331 0.946098054588918 0.457269233600447 0.539326812115034 miRanda -0.196043223886578 0.00627089530211866 NA NA NA hsa-miR-15a-5p AKT3 -0.0674049094129128 0.964835434214123 0.457269233600447 0.539326812115034 miRNAWalker2_validate;miRTarBase;miRNATAP -0.721206491484116 7.61586942839311e-13 NA NA NA hsa-miR-15b-5p AKT3 -0.272614787130877 0.87096541832188 0.457269233600447 0.539326812115034 miRNATAP -0.665977383717092 1.97063059627596e-12 NA NA NA hsa-miR-16-5p AKT3 0.0135949734723564 0.994476223855607 0.457269233600447 0.539326812115034 miRNAWalker2_validate;miRTarBase;miRNATAP -0.746124766270904 9.10401236853758e-16 NA NA NA hsa-miR-17-3p AKT3 0.100221625453134 0.960113387014848 0.457269233600447 0.539326812115034 miRNATAP -0.519758313376015 2.03997342351785e-09 NA NA NA hsa-miR-17-5p AKT3 -0.175448849583061 0.934544015912731 0.457269233600447 0.539326812115034 TargetScan;miRNATAP -0.626536048377156 1.11076874125702e-18 NA NA NA hsa-miR-181b-5p AKT3 0.155313039554487 0.930176779696506 0.457269233600447 0.539326812115034 miRNATAP -0.268064668813324 0.00963449049657038 NA NA NA hsa-miR-20a-5p AKT3 -0.179153323927949 0.928118119139752 0.457269233600447 0.539326812115034 miRNATAP -0.531063551395964 1.32783278364081e-13 NA NA NA hsa-miR-28-3p AKT3 -0.227916837431808 0.935350995840384 0.457269233600447 0.539326812115034 miRNATAP -0.521845591393563 0.00718630427898147 NA NA NA hsa-miR-29a-3p AKT3 0.01127474410284 0.996977020481272 0.457269233600447 0.539326812115034 miRNATAP -0.812359982380835 1.03842433672581e-13 NA NA NA hsa-miR-29b-3p AKT3 -0.104016192263954 0.958988036765397 0.457269233600447 0.539326812115034 miRNATAP -0.677276652111253 9.58518141369729e-17 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-32-3p AKT3 -0.568003960723004 0.13133163420273 0.457269233600447 0.539326812115034 mirMAP -0.563455040593992 1.29815959529041e-22 NA NA NA hsa-miR-320a AKT3 -0.416546433767628 0.840202138616422 0.457269233600447 0.539326812115034 PITA;miRanda;miRNATAP -0.333446337886203 0.00137735387479576 NA NA NA hsa-miR-320b AKT3 -0.23561798088153 0.859222532827992 0.457269233600447 0.539326812115034 PITA;miRanda;miRNATAP -0.247020375326149 0.00854841822062789 NA NA NA hsa-miR-335-3p AKT3 -0.244830745789445 0.88450019116631 0.457269233600447 0.539326812115034 mirMAP -0.579661626156677 1.71660731221086e-14 NA NA NA hsa-miR-33a-3p AKT3 -0.794543849238581 0.0105203072007922 0.457269233600447 0.539326812115034 mirMAP -0.48908545949649 5.69174183767199e-12 NA NA NA hsa-miR-340-5p AKT3 -0.00276909425328853 0.99757361161055 0.457269233600447 0.539326812115034 mirMAP -0.282303409119482 0.00600476945925659 NA NA NA hsa-miR-362-3p AKT3 -0.721040238345347 0.0345881362485733 0.457269233600447 0.539326812115034 miRanda -0.415414242264488 1.82625494243827e-09 NA NA NA hsa-miR-362-5p AKT3 -0.26647467080141 0.752024885130738 0.457269233600447 0.539326812115034 PITA;TargetScan;miRNATAP -0.516617267683569 4.2053666241316e-16 NA NA NA hsa-miR-369-3p AKT3 0.116576891957687 0.83230082995912 0.457269233600447 0.539326812115034 mirMAP -0.2347933374382 0.00901179401751285 NA NA NA hsa-miR-374a-5p AKT3 -0.343007247142618 0.766921280269271 0.457269233600447 0.539326812115034 mirMAP -0.579942468779622 2.643062323348e-06 NA NA NA hsa-miR-374b-5p AKT3 -0.285682091626878 0.83569830479965 0.457269233600447 0.539326812115034 mirMAP -0.684416910019692 6.98155817205318e-09 NA NA NA hsa-miR-421 AKT3 -0.182032017078616 0.734704500318599 0.457269233600447 0.539326812115034 miRanda;mirMAP -0.463766741666901 1.36843495165118e-08 NA NA NA hsa-miR-424-5p AKT3 0.247080963500746 0.870154571783568 0.457269233600447 0.539326812115034 miRNATAP -0.239499066096292 0.00104453067376223 26315541 Silencing Akt3 and E2F3 by siRNA pheno-copied the effect of ectopic miR-424 on HCC growth; Whereas overexpression of Akt3 and E2F3 attenuated the effect of miR-424 on HCC growth liver cancer hsa-miR-501-3p AKT3 -0.753812576327832 0.552763280802254 0.457269233600447 0.539326812115034 miRNATAP -0.497935902986368 2.06014814106823e-10 NA NA NA hsa-miR-502-3p AKT3 -0.481234445251923 0.514301076452422 0.457269233600447 0.539326812115034 miRNATAP -0.644160673294049 1.58962279838432e-12 NA NA NA hsa-miR-502-5p AKT3 -0.708507838520586 0.0261309781860104 0.457269233600447 0.539326812115034 PITA;miRNATAP -0.409328372897747 4.31887851181114e-09 NA NA NA hsa-miR-505-3p AKT3 -0.469094267152605 0.690382680489578 0.457269233600447 0.539326812115034 mirMAP -0.774927841273818 6.77311058531751e-15 22051041 We also find that Akt3 correlate inversely with miR-505 modulates drug sensitivity in MCF7-ADR breast cancer hsa-miR-548o-3p AKT3 -0.191447572716994 0.517725546183501 0.457269233600447 0.539326812115034 mirMAP -0.314174287829114 7.58105126731538e-05 NA NA NA hsa-miR-577 AKT3 -1.06238199218774 0.326056761787754 0.457269233600447 0.539326812115034 mirMAP -0.383091519653111 6.42065724452006e-20 NA NA NA hsa-miR-663b AKT3 0.101100389887233 0.814989939749933 0.457269233600447 0.539326812115034 PITA -0.247711064601903 1.07528758067609e-05 NA NA NA hsa-miR-769-5p AKT3 -0.306614906942583 0.735704301598833 0.457269233600447 0.539326812115034 PITA;miRNATAP -0.8409977584726 1.11686042031466e-14 NA NA NA hsa-miR-93-5p AKT3 -0.611073677204699 0.825297877093193 0.457269233600447 0.539326812115034 miRNATAP -0.762020096686085 6.75211862260925e-18 NA NA NA hsa-let-7a-5p BCL2L1 -0.0620211756550422 0.985006886285188 0.242557541702429 0.890959530804569 TargetScan;miRNATAP -0.267237022843277 0.00149660612153832 26915294;20347499 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;The let 7 family of microRNAs inhibits Bcl xL expression and potentiates sorafenib induced apoptosis in human hepatocellular carcinoma; The effect of let-7 on Bcl-xL expression was examined by Western blot and a reporter assay; Microarray analysis followed by in silico target prediction identified let-7 microRNAs as being downregulated in Huh7 hepatoma cells in comparison with primary human hepatocytes as well as possessing a putative target site in the bcl-xl mRNA poor survival; lung cancer;liver cancer hsa-miR-106b-5p CBL -0.297128724729339 0.869294443540749 0.103532236912373 0.93035075735035 mirMAP -0.114963340675064 0.00124299433422783 NA NA NA hsa-miR-542-3p CBL 0.188168046511374 0.909252939431573 0.103532236912373 0.93035075735035 miRNATAP -0.105262762313292 0.00537467115841884 NA NA NA hsa-miR-582-3p CBL -0.2334649592375 0.897678119160318 0.103532236912373 0.93035075735035 mirMAP -0.12252404869057 0.000148094295715617 NA NA NA hsa-miR-98-5p CBL -0.168162186023221 0.898802461503524 0.103532236912373 0.93035075735035 MirTarget -0.129743172347668 0.00205358303722267 NA NA NA hsa-miR-29a-5p CBLB -0.31835175571979 0.600442757817281 -0.141240928037213 0.895708622628861 MirTarget -0.124246581923014 0.000196871411430037 NA NA NA hsa-miR-335-3p CBLB -0.244830745789445 0.88450019116631 -0.141240928037213 0.895708622628861 mirMAP -0.155934372169217 2.33722978058411e-06 NA NA NA hsa-miR-421 CBLB -0.182032017078616 0.734704500318599 -0.141240928037213 0.895708622628861 miRanda -0.175721990097152 3.57821581130622e-07 NA NA NA hsa-miR-16-5p CCND1 0.0135949734723564 0.994476223855607 -0.254128537418143 0.890666103231997 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.131352085119981 0.00823300401924536 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-195-5p CCND1 0.343201952346823 0.749622318650888 -0.254128537418143 0.890666103231997 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.135964440478054 0.00272099018653157 21350001;26631043;25823925 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma ;;metastasis;poor survival breast cancer;cervical and endocervical cancer;sarcoma hsa-miR-29c-3p CCND1 0.162451700202704 0.942720457512509 -0.254128537418143 0.890666103231997 mirMAP -0.140688238276882 0.00181263740987372 NA NA NA hsa-miR-30c-5p CLCF1 -0.298383882401475 0.865809030482001 0.339939986578992 0.571760444123412 miRNATAP -0.267091209822215 0.00211825475580295 NA NA NA hsa-miR-30d-5p CLCF1 -0.168211838771867 0.95173197030375 0.339939986578992 0.571760444123412 miRNATAP -0.214927847032566 0.00611378330914109 NA NA NA hsa-miR-362-3p CLCF1 -0.721040238345347 0.0345881362485733 0.339939986578992 0.571760444123412 miRanda -0.13505602289613 0.00725860488331613 NA NA NA hsa-miR-429 CLCF1 -0.456485631615963 0.806240953400535 0.339939986578992 0.571760444123412 miRanda;miRNATAP -0.19993664298022 3.54256327872278e-05 NA NA NA hsa-miR-200b-3p CNTFR -0.426401948379212 0.863957108574195 1.94368273462245 0.0326705427664545 TargetScan -0.594871652538133 0.00240616582839974 NA NA NA hsa-miR-200c-3p CNTFR -0.437282635857873 0.887118598436407 1.94368273462245 0.0326705427664545 miRNATAP -0.923465419965485 3.44238295755302e-06 NA NA NA hsa-miR-27b-5p CNTFR -0.331337007788532 0.686623472774964 1.94368273462245 0.0326705427664545 miRNATAP -0.974999359212462 0.00072771720603146 NA NA NA hsa-miR-493-5p CREBBP 0.229930075372342 0.731979520100109 -0.0709718431637629 0.963143997108611 miRNATAP -0.131589658655616 0.000363570308901921 NA NA NA hsa-miR-429 CSF2RA -0.456485631615963 0.806240953400535 -0.351674134974543 0.500190695808141 miRanda -0.376880533087412 3.93358341034075e-06 NA NA NA hsa-miR-590-3p CSF2RA -0.279244755376859 0.59126669933662 -0.351674134974543 0.500190695808141 mirMAP -0.385196606283209 8.16674636072508e-06 NA NA NA hsa-miR-15b-3p CSF2RB -0.557749208157585 0.609181305423188 -0.424243791231997 0.608009754706655 mirMAP -0.556320542920735 1.69990147768674e-07 NA NA NA hsa-miR-186-5p CSF2RB -0.318786974828757 0.85412722938961 -0.424243791231997 0.608009754706655 mirMAP -0.525426499153246 0.000371798037133893 NA NA NA hsa-miR-19a-3p CSF2RB -0.206793507801887 0.844637784802316 -0.424243791231997 0.608009754706655 MirTarget -0.505159885757328 3.13732608161195e-09 NA NA NA hsa-miR-19b-3p CSF2RB -0.0268530183621474 0.986656783046572 -0.424243791231997 0.608009754706655 MirTarget -0.674202290730517 2.38029074307712e-11 NA NA NA hsa-miR-30b-3p CSF2RB -0.514644352757504 0.162424853398397 -0.424243791231997 0.608009754706655 MirTarget -0.432501376695226 2.00030751491199e-05 NA NA NA hsa-miR-452-3p CSF2RB -0.167134177977311 0.799008246175244 -0.424243791231997 0.608009754706655 mirMAP -0.426783979867021 4.47079759509159e-09 NA NA NA hsa-miR-532-5p CSF2RB -0.349665553500088 0.878948352437467 -0.424243791231997 0.608009754706655 MirTarget -0.370796066761641 0.000414661072596092 NA NA NA hsa-miR-576-5p CSF2RB -0.506413219377403 0.417187951364173 -0.424243791231997 0.608009754706655 miRNATAP -0.357189326802445 0.000704779079248235 NA NA NA hsa-miR-590-3p CSF2RB -0.279244755376859 0.59126669933662 -0.424243791231997 0.608009754706655 miRanda;mirMAP -0.393241297046802 6.12226396413448e-06 NA NA NA hsa-miR-625-5p CSF2RB -0.690759472145277 0.210306534567564 -0.424243791231997 0.608009754706655 MirTarget -0.28968042535212 0.000169238256842656 NA NA NA hsa-miR-30b-3p CSF3R -0.514644352757504 0.162424853398397 -0.471236404125504 0.478352750469895 MirTarget -0.5313140628677 1.80158939385715e-05 NA NA NA hsa-miR-361-5p CSF3R -0.138735309928775 0.941495130308343 -0.471236404125504 0.478352750469895 miRanda -0.618281735002952 0.00471250922014669 NA NA NA hsa-miR-429 CSF3R -0.456485631615963 0.806240953400535 -0.471236404125504 0.478352750469895 miRanda -0.514449210216783 2.67005810481134e-07 NA NA NA hsa-miR-940 CSF3R -0.225788347550697 0.680055767105815 -0.471236404125504 0.478352750469895 MirTarget -0.345115039813433 0.000168588258554028 NA NA NA hsa-miR-185-3p CTF1 0.100697585937245 0.856913315942984 0.535079010670358 0.159729215238009 MirTarget -0.323763442894808 0.00147345839474818 NA NA NA hsa-miR-185-5p CTF1 -0.294432218239008 0.820591478398594 0.535079010670358 0.159729215238009 MirTarget -0.748795398944076 4.09122899822073e-08 NA NA NA hsa-miR-590-3p CTF1 -0.279244755376859 0.59126669933662 0.535079010670358 0.159729215238009 miRanda -0.459661300355365 1.24913708943404e-08 NA NA NA hsa-miR-940 CTF1 -0.225788347550697 0.680055767105815 0.535079010670358 0.159729215238009 MirTarget -0.236178169409042 0.000863113835777616 NA NA NA hsa-miR-106b-5p EP300 -0.297128724729339 0.869294443540749 -0.275785871935125 0.858275138267876 miRNATAP -0.130709049655062 0.000960073772533261 NA NA NA hsa-miR-26b-5p EP300 -0.0245931278499594 0.990377966314923 -0.275785871935125 0.858275138267876 miRNAWalker2_validate;miRNATAP -0.122462053179979 0.0081599533716202 NA NA NA hsa-miR-339-5p EP300 -0.300425087100667 0.712912847076788 -0.275785871935125 0.858275138267876 miRanda -0.107604978422911 0.000130192205849388 NA NA NA hsa-miR-369-3p EP300 0.116576891957687 0.83230082995912 -0.275785871935125 0.858275138267876 MirTarget;PITA;miRNATAP -0.151763068163101 1.43595410012867e-05 NA NA NA hsa-let-7f-5p GHR 0.048789917034723 0.987280455481631 0.570638667569632 0.245024953773014 miRNATAP -0.550957043817317 0.00307995104158157 NA NA NA hsa-let-7g-5p GHR -0.200947212961157 0.922992045181955 0.570638667569632 0.245024953773014 miRNATAP -0.548129375387392 0.00375308103747239 NA NA NA hsa-miR-142-3p GHR -0.154235241441331 0.946098054588918 0.570638667569632 0.245024953773014 MirTarget;PITA;miRanda;miRNATAP -0.25845608963523 0.00874573277743459 NA NA NA hsa-miR-15a-5p GHR -0.0674049094129128 0.964835434214123 0.570638667569632 0.245024953773014 MirTarget;miRNATAP -0.771410096762057 5.05122129996976e-08 NA NA NA hsa-miR-15b-5p GHR -0.272614787130877 0.87096541832188 0.570638667569632 0.245024953773014 MirTarget;miRNATAP -0.867389448225228 3.31080514273422e-11 NA NA NA hsa-miR-16-2-3p GHR -0.36717860153421 0.546850726070016 0.570638667569632 0.245024953773014 mirMAP -0.611850858331784 1.27046878075512e-08 NA NA NA hsa-miR-16-5p GHR 0.0135949734723564 0.994476223855607 0.570638667569632 0.245024953773014 MirTarget;miRNATAP -0.8072370172485 7.84861031393396e-10 NA NA NA hsa-miR-29a-5p GHR -0.31835175571979 0.600442757817281 0.570638667569632 0.245024953773014 mirMAP;miRNATAP -0.413065589121629 0.0001546034228248 NA NA NA hsa-miR-33a-3p GHR -0.794543849238581 0.0105203072007922 0.570638667569632 0.245024953773014 miRNATAP -0.350374540395823 0.000555682054497104 NA NA NA hsa-miR-429 GHR -0.456485631615963 0.806240953400535 0.570638667569632 0.245024953773014 miRanda;miRNATAP -0.385654617034442 4.28729865433817e-05 NA NA NA hsa-miR-590-3p GHR -0.279244755376859 0.59126669933662 0.570638667569632 0.245024953773014 mirMAP -0.659886137629109 6.90155909931775e-12 NA NA NA hsa-miR-624-5p GHR -0.348001560408561 0.190596385087429 0.570638667569632 0.245024953773014 MirTarget -0.393085612074636 0.00108743183258024 NA NA NA hsa-miR-7-1-3p GHR -0.462485777435991 0.665899751398166 0.570638667569632 0.245024953773014 MirTarget;mirMAP -0.694008690868991 1.13461523739526e-09 NA NA NA hsa-miR-106b-5p IFNAR2 -0.297128724729339 0.869294443540749 0.0549290953725192 0.956270498622373 miRNAWalker2_validate -0.119924026344003 0.000258511606081136 NA NA NA hsa-miR-181b-5p IFNGR1 0.155313039554487 0.930176779696506 -0.0132059121215864 0.993091313110392 miRNAWalker2_validate -0.128982711582396 0.00808633771710119 NA NA NA hsa-let-7d-5p IL10 -0.139747701175051 0.934164162708487 0.167511993444373 0.797374366139707 miRNATAP -0.639598067421236 0.000637900148181991 NA NA NA hsa-let-7g-5p IL10 -0.200947212961157 0.922992045181955 0.167511993444373 0.797374366139707 miRNATAP -0.844826152370777 2.41308893073987e-06 NA NA NA hsa-miR-106a-5p IL10 -0.203919267842652 0.802213958426804 0.167511993444373 0.797374366139707 miRNAWalker2_validate -0.340426595350092 0.00302645223420035 NA NA NA hsa-miR-27a-3p IL10 -0.123902317731458 0.958804393510999 0.167511993444373 0.797374366139707 miRNATAP -0.742980986429298 5.27554670689172e-05 NA NA NA hsa-miR-27b-3p IL10 -0.14277121795778 0.951937409841932 0.167511993444373 0.797374366139707 miRNATAP -0.686292041417788 0.00124639329492394 NA NA NA hsa-miR-32-3p IL10 -0.568003960723004 0.13133163420273 0.167511993444373 0.797374366139707 mirMAP -0.43348336754303 1.22041729053869e-07 NA NA NA hsa-miR-361-5p IL10 -0.138735309928775 0.941495130308343 0.167511993444373 0.797374366139707 MirTarget;PITA;miRanda;miRNATAP -0.60597963352423 0.00198544359061753 NA NA NA hsa-miR-374b-5p IL10 -0.285682091626878 0.83569830479965 0.167511993444373 0.797374366139707 miRNATAP -0.758312249761257 1.60084328115915e-06 NA NA NA hsa-miR-421 IL10 -0.182032017078616 0.734704500318599 0.167511993444373 0.797374366139707 miRanda -0.305109562048664 0.0059859660219526 NA NA NA hsa-miR-552-3p IL10 0.172135417326455 0.893972136172394 0.167511993444373 0.797374366139707 MirTarget -0.195321787950436 0.000349987206433933 NA NA NA hsa-miR-590-3p IL10 -0.279244755376859 0.59126669933662 0.167511993444373 0.797374366139707 miRanda;mirMAP -0.384230226141038 6.08201090429342e-05 NA NA NA hsa-miR-590-5p IL10 -0.547819833829572 0.472735645776647 0.167511993444373 0.797374366139707 miRanda -0.557188165184462 2.22602238602186e-08 NA NA NA hsa-miR-421 IL10RA -0.182032017078616 0.734704500318599 -0.439563652857201 0.622097239513891 miRanda -0.417833873596013 3.9205262441602e-06 NA NA NA hsa-miR-1275 IL12RB2 -0.831342050607648 0.0803795852164229 -0.0764820695153088 0.87219219920631 MirTarget -0.199483074951665 0.00161480424701706 NA NA NA hsa-miR-339-5p IL12RB2 -0.300425087100667 0.712912847076788 -0.0764820695153088 0.87219219920631 miRanda -0.307755570750889 0.000172472182589488 NA NA NA hsa-miR-590-5p IL12RB2 -0.547819833829572 0.472735645776647 -0.0764820695153088 0.87219219920631 miRanda -0.283396798758208 0.00138689356734015 NA NA NA hsa-miR-192-5p IL15 -0.117345487848223 0.972927287653137 -0.135279021780411 0.764609674137587 miRNAWalker2_validate -0.151053187547341 0.00699410265424154 NA NA NA hsa-miR-301a-3p IL15 -0.105312511901769 0.831686745977347 -0.135279021780411 0.764609674137587 MirTarget -0.197255112556622 0.00128962241230851 NA NA NA hsa-miR-374b-5p IL15 -0.285682091626878 0.83569830479965 -0.135279021780411 0.764609674137587 MirTarget -0.262624821780781 0.00746103752526978 NA NA NA hsa-miR-421 IL15 -0.182032017078616 0.734704500318599 -0.135279021780411 0.764609674137587 miRanda -0.254696023853041 0.000150509084967204 NA NA NA hsa-miR-139-5p IL20RA -0.0810891026597322 0.928690377743652 -0.173885067076386 0.875029710803881 miRanda -0.18584595183927 0.00166437067999008 NA NA NA hsa-miR-24-2-5p IL21R -0.0947200031589666 0.920155111594601 -0.615154572576549 0.218516474955849 MirTarget -0.454387631421917 0.00135399968971066 NA NA NA hsa-miR-24-3p IL21R -0.0484778924256624 0.985274054814493 -0.615154572576549 0.218516474955849 MirTarget -0.778457504842584 0.000450659852519707 NA NA NA hsa-miR-335-5p IL21R -0.0284895175847679 0.973380867832231 -0.615154572576549 0.218516474955849 miRNAWalker2_validate -0.657308497967597 1.41736461325413e-11 NA NA NA hsa-miR-421 IL21R -0.182032017078616 0.734704500318599 -0.615154572576549 0.218516474955849 miRanda -0.433898074148801 3.58986485715043e-05 NA NA NA hsa-miR-335-3p IL22RA2 -0.244830745789445 0.88450019116631 -0.720760060484687 0.414286547262146 mirMAP -0.454678258011894 0.000142794730882447 NA NA NA hsa-miR-125a-3p IL23R 0.14689780893708 0.724764670752407 -0.307953449950422 0.512401637581722 miRanda -0.268251786096324 0.000257518070139672 NA NA NA hsa-miR-146b-5p IL23R -0.402662509440887 0.837510937985091 -0.307953449950422 0.512401637581722 miRanda -0.442703436192538 2.31190316554542e-05 NA NA NA hsa-miR-330-5p IL23R -0.283418953659271 0.815687101334695 -0.307953449950422 0.512401637581722 miRanda -0.386494057508855 0.00146785288897821 NA NA NA hsa-miR-224-3p IL2RA 0.110372723153393 0.749091467231007 -0.417788171272967 0.415377591508965 MirTarget -0.358356636913746 0.000226508715698861 NA NA NA hsa-miR-500a-3p IL2RA -0.633375813338735 0.732582832733155 -0.417788171272967 0.415377591508965 MirTarget -0.352734550527931 0.00419836632010245 NA NA NA hsa-miR-421 IL2RB -0.182032017078616 0.734704500318599 -0.861924307640201 0.313939459147822 mirMAP -0.291499452428397 0.00219078812803157 NA NA NA hsa-miR-362-3p IL3RA -0.721040238345347 0.0345881362485733 0.163928312094029 0.804758258942851 miRanda -0.169156809721412 0.00190481779053269 NA NA NA hsa-miR-335-5p IL6 -0.0284895175847679 0.973380867832231 0.0493336463322382 0.935900126013578 miRNAWalker2_validate -0.521128064809697 0.000256062993843235 NA NA NA hsa-miR-429 IL6 -0.456485631615963 0.806240953400535 0.0493336463322382 0.935900126013578 miRanda -0.46097989287392 0.000176679583532699 NA NA NA hsa-let-7g-5p IL6R -0.200947212961157 0.922992045181955 0.14029594340371 0.828138988034461 miRNATAP -0.504676085284238 0.000139207492000278 NA NA NA hsa-miR-106b-5p IL6R -0.297128724729339 0.869294443540749 0.14029594340371 0.828138988034461 mirMAP -0.414993313904555 1.66588405858962e-05 NA NA NA hsa-miR-130b-3p IL6R -0.221667315324818 0.824660172394714 0.14029594340371 0.828138988034461 mirMAP -0.37520088997967 1.41242079938231e-05 NA NA NA hsa-miR-141-3p IL6R -0.31994058840327 0.87774106909065 0.14029594340371 0.828138988034461 MirTarget -0.260278088312821 0.000281825033488117 NA NA NA hsa-miR-141-5p IL6R -0.354590233549885 0.867642456336402 0.14029594340371 0.828138988034461 MirTarget -0.223418998455398 0.00375220429656306 NA NA NA hsa-miR-148a-5p IL6R -0.448099743845604 0.748419139652266 0.14029594340371 0.828138988034461 mirMAP -0.222029065891081 0.00845183949353713 NA NA NA hsa-miR-17-5p IL6R -0.175448849583061 0.934544015912731 0.14029594340371 0.828138988034461 mirMAP -0.348432376185475 1.8700645271031e-06 NA NA NA hsa-miR-182-5p IL6R -0.104238497940557 0.973380614062243 0.14029594340371 0.828138988034461 mirMAP -0.283194457844622 0.000138166201195752 NA NA NA hsa-miR-193b-3p IL6R 0.0672068426635715 0.951480422273678 0.14029594340371 0.828138988034461 mirMAP -0.238067342254597 0.00256577376604153 NA NA NA hsa-miR-200a-3p IL6R -0.367034437440907 0.851059894150266 0.14029594340371 0.828138988034461 MirTarget -0.203072468846452 0.00380625152233845 NA NA NA hsa-miR-20a-5p IL6R -0.179153323927949 0.928118119139752 0.14029594340371 0.828138988034461 mirMAP -0.312547682443889 1.55742175867736e-05 NA NA NA hsa-miR-29a-5p IL6R -0.31835175571979 0.600442757817281 0.14029594340371 0.828138988034461 mirMAP -0.259936171679278 0.000767742491585924 NA NA NA hsa-miR-29b-1-5p IL6R -0.642348119412534 0.293891497238796 0.14029594340371 0.828138988034461 mirMAP -0.167846750014706 0.00553245052066504 NA NA NA hsa-miR-30b-5p IL6R -0.0121430518253582 0.994622896704513 0.14029594340371 0.828138988034461 mirMAP -0.261870960822981 0.00166231883367778 NA NA NA hsa-miR-30c-5p IL6R -0.298383882401475 0.865809030482001 0.14029594340371 0.828138988034461 mirMAP -0.349580599174505 0.00346490473427868 NA NA NA hsa-miR-331-3p IL6R -0.40204226129616 0.670588911553669 0.14029594340371 0.828138988034461 MirTarget -0.242281109107159 0.00805273236084106 NA NA NA hsa-miR-335-5p IL6R -0.0284895175847679 0.973380867832231 0.14029594340371 0.828138988034461 mirMAP -0.315149839964086 4.29309729140907e-05 NA NA NA hsa-miR-33a-5p IL6R -0.205788753603336 0.853314500865147 0.14029594340371 0.828138988034461 mirMAP -0.173517877899447 0.000139955248140828 NA NA NA hsa-miR-454-3p IL6R -0.101514866328011 0.843545158256191 0.14029594340371 0.828138988034461 mirMAP -0.322679864043225 0.00143735279785052 NA NA NA hsa-miR-484 IL6R -0.179977202691249 0.886333755572375 0.14029594340371 0.828138988034461 MirTarget -0.288401799761055 0.00664672938128289 NA NA NA hsa-miR-576-5p IL6R -0.506413219377403 0.417187951364173 0.14029594340371 0.828138988034461 mirMAP -0.258425586928707 0.00235230304287871 NA NA NA hsa-miR-590-5p IL6R -0.547819833829572 0.472735645776647 0.14029594340371 0.828138988034461 MirTarget;miRNATAP -0.224061981438517 0.00276804787475256 NA NA NA hsa-miR-93-5p IL6R -0.611073677204699 0.825297877093193 0.14029594340371 0.828138988034461 mirMAP -0.347827855898408 0.000144066850938172 NA NA NA hsa-let-7a-3p IL6ST -0.215598045625677 0.85543299203799 -0.112823587378398 0.902159423718375 mirMAP -0.462380603035303 1.58090637221431e-08 NA NA NA hsa-let-7f-1-3p IL6ST -0.31101436822914 0.693407210545374 -0.112823587378398 0.902159423718375 mirMAP -0.410895678665136 0.000316912992017457 NA NA NA hsa-let-7f-2-3p IL6ST -0.0455032713433074 0.882115725419367 -0.112823587378398 0.902159423718375 mirMAP -0.421010435850214 1.93109254502541e-11 NA NA NA hsa-miR-101-5p IL6ST -0.27876696778882 0.558836382493107 -0.112823587378398 0.902159423718375 mirMAP -0.276824994331068 1.24625843329489e-05 NA NA NA hsa-miR-125a-3p IL6ST 0.14689780893708 0.724764670752407 -0.112823587378398 0.902159423718375 miRanda -0.180998763727289 0.00264887737730496 NA NA NA hsa-miR-130a-3p IL6ST 0.0910074087716906 0.929098200371948 -0.112823587378398 0.902159423718375 mirMAP;miRNATAP -0.346895862273797 7.41948763076216e-06 NA NA NA hsa-miR-130b-3p IL6ST -0.221667315324818 0.824660172394714 -0.112823587378398 0.902159423718375 miRNATAP -0.617341914345858 2.31061826500639e-17 NA NA NA hsa-miR-135b-5p IL6ST 0.631573976263484 0.610028066417462 -0.112823587378398 0.902159423718375 mirMAP -0.271776033242815 1.34921206269976e-09 NA NA NA hsa-miR-136-5p IL6ST -0.0340893286426032 0.965134296676505 -0.112823587378398 0.902159423718375 MirTarget -0.242860296699271 0.000363199714201219 NA NA NA hsa-miR-148a-3p IL6ST -0.101286586375016 0.976980454193186 -0.112823587378398 0.902159423718375 MirTarget;miRNATAP -0.297311345955798 0.000121848325439517 NA NA NA hsa-miR-148b-5p IL6ST -0.236618793990305 0.43925706879726 -0.112823587378398 0.902159423718375 mirMAP -0.327357191034401 1.59651642754183e-06 NA NA NA hsa-miR-154-3p IL6ST -0.170366170038505 0.546500133020447 -0.112823587378398 0.902159423718375 mirMAP -0.221751172797578 0.00246977328345561 NA NA NA hsa-miR-16-1-3p IL6ST 0.151694812889216 0.733736501874638 -0.112823587378398 0.902159423718375 mirMAP -0.205312410383285 0.00209375416231663 NA NA NA hsa-miR-16-2-3p IL6ST -0.36717860153421 0.546850726070016 -0.112823587378398 0.902159423718375 mirMAP -0.380442186658243 2.05264169530697e-08 NA NA NA hsa-miR-17-5p IL6ST -0.175448849583061 0.934544015912731 -0.112823587378398 0.902159423718375 TargetScan -0.423702230369232 3.05539987964916e-11 NA NA NA hsa-miR-182-5p IL6ST -0.104238497940557 0.973380614062243 -0.112823587378398 0.902159423718375 mirMAP -0.189971673580214 0.00450657290897378 NA NA NA hsa-miR-186-5p IL6ST -0.318786974828757 0.85412722938961 -0.112823587378398 0.902159423718375 MirTarget;mirMAP -0.500938653506159 1.75914378217362e-06 NA NA NA hsa-miR-190a-5p IL6ST -0.275531208543264 0.538488213403162 -0.112823587378398 0.902159423718375 MirTarget -0.299433239074495 1.25089820518412e-05 NA NA NA hsa-miR-192-5p IL6ST -0.117345487848223 0.972927287653137 -0.112823587378398 0.902159423718375 miRNAWalker2_validate -0.327855290194502 2.11164589173932e-08 NA NA NA hsa-miR-19a-3p IL6ST -0.206793507801887 0.844637784802316 -0.112823587378398 0.902159423718375 mirMAP;miRNATAP -0.410395967383545 1.18044808948445e-11 NA NA NA hsa-miR-19b-3p IL6ST -0.0268530183621474 0.986656783046572 -0.112823587378398 0.902159423718375 mirMAP;miRNATAP -0.474221018020512 6.67339514801462e-11 NA NA NA hsa-miR-200a-5p IL6ST -0.671005453811576 0.78126028567661 -0.112823587378398 0.902159423718375 mirMAP -0.229769184693614 0.00092862282127845 NA NA NA hsa-miR-200b-3p IL6ST -0.426401948379212 0.863957108574195 -0.112823587378398 0.902159423718375 TargetScan;mirMAP -0.321845343513058 1.07600487763269e-05 NA NA NA hsa-miR-200b-5p IL6ST -0.502275384207405 0.722255155236927 -0.112823587378398 0.902159423718375 mirMAP -0.364606019128497 5.86372318778233e-08 NA NA NA hsa-miR-200c-3p IL6ST -0.437282635857873 0.887118598436407 -0.112823587378398 0.902159423718375 mirMAP -0.286378721954986 0.000154378611256551 NA NA NA hsa-miR-20a-3p IL6ST 0.456808229166028 0.57674056136504 -0.112823587378398 0.902159423718375 mirMAP -0.272813902662393 1.40977963922188e-07 NA NA NA hsa-miR-2110 IL6ST -0.317803483266315 0.250981343062022 -0.112823587378398 0.902159423718375 MirTarget -0.22266892198699 0.00244018985366956 NA NA NA hsa-miR-23a-3p IL6ST -0.122198715333656 0.962717452143511 -0.112823587378398 0.902159423718375 MirTarget -0.411478838146585 0.00344941232193335 NA NA NA hsa-miR-24-1-5p IL6ST -0.185440327527663 0.791525781516963 -0.112823587378398 0.902159423718375 MirTarget -0.274195715029724 0.00290080724275058 NA NA NA hsa-miR-24-2-5p IL6ST -0.0947200031589666 0.920155111594601 -0.112823587378398 0.902159423718375 MirTarget -0.735533959418999 8.68540512426714e-16 NA NA NA hsa-miR-26a-1-3p IL6ST -0.429875601809349 0.182136384322617 -0.112823587378398 0.902159423718375 MirTarget -0.251489704246768 9.87806269175692e-05 NA NA NA hsa-miR-26a-2-3p IL6ST -0.427772454814258 0.28776911697575 -0.112823587378398 0.902159423718375 MirTarget -0.341601297358784 3.66659679593891e-07 NA NA NA hsa-miR-26b-5p IL6ST -0.0245931278499594 0.990377966314923 -0.112823587378398 0.902159423718375 mirMAP -0.636992222197543 6.787452165059e-11 NA NA NA hsa-miR-29a-5p IL6ST -0.31835175571979 0.600442757817281 -0.112823587378398 0.902159423718375 mirMAP -0.50682566703328 9.18946787937813e-15 NA NA NA hsa-miR-29b-1-5p IL6ST -0.642348119412534 0.293891497238796 -0.112823587378398 0.902159423718375 MirTarget -0.288706675728696 4.34635352521968e-08 NA NA NA hsa-miR-29b-3p IL6ST -0.104016192263954 0.958988036765397 -0.112823587378398 0.902159423718375 mirMAP -0.486933043662304 1.77165156250254e-11 NA NA NA hsa-miR-301a-3p IL6ST -0.105312511901769 0.831686745977347 -0.112823587378398 0.902159423718375 mirMAP;miRNATAP -0.312888709203455 1.40371234190449e-06 NA NA NA hsa-miR-30b-5p IL6ST -0.0121430518253582 0.994622896704513 -0.112823587378398 0.902159423718375 mirMAP -0.492529909328333 5.02014087138277e-12 NA NA NA hsa-miR-30c-5p IL6ST -0.298383882401475 0.865809030482001 -0.112823587378398 0.902159423718375 mirMAP -0.582463059214572 2.24578503007396e-08 NA NA NA hsa-miR-30e-5p IL6ST -0.0657075181381011 0.979684509181941 -0.112823587378398 0.902159423718375 mirMAP -0.322909508812745 0.00636179131174326 NA NA NA hsa-miR-32-3p IL6ST -0.568003960723004 0.13133163420273 -0.112823587378398 0.902159423718375 mirMAP -0.399383640091961 1.31339712327425e-14 NA NA NA hsa-miR-323a-3p IL6ST 0.279126405514894 0.478782330851768 -0.112823587378398 0.902159423718375 MirTarget;mirMAP -0.304869535381375 1.92194733263176e-06 NA NA NA hsa-miR-335-3p IL6ST -0.244830745789445 0.88450019116631 -0.112823587378398 0.902159423718375 MirTarget;mirMAP -0.355050147129413 1.58783613430047e-07 NA NA NA hsa-miR-335-5p IL6ST -0.0284895175847679 0.973380867832231 -0.112823587378398 0.902159423718375 miRNAWalker2_validate -0.437807448802237 5.79373134881004e-11 NA NA NA hsa-miR-33a-3p IL6ST -0.794543849238581 0.0105203072007922 -0.112823587378398 0.902159423718375 mirMAP -0.237163641513608 0.000202723132026942 NA NA NA hsa-miR-33a-5p IL6ST -0.205788753603336 0.853314500865147 -0.112823587378398 0.902159423718375 mirMAP -0.262434765240681 2.64616100519126e-11 NA NA NA hsa-miR-33b-5p IL6ST -0.161971614375297 0.737436207821109 -0.112823587378398 0.902159423718375 mirMAP -0.226684321685931 3.60296237559028e-07 NA NA NA hsa-miR-361-5p IL6ST -0.138735309928775 0.941495130308343 -0.112823587378398 0.902159423718375 mirMAP -0.435521035838156 0.000671552721417052 NA NA NA hsa-miR-362-3p IL6ST -0.721040238345347 0.0345881362485733 -0.112823587378398 0.902159423718375 PITA;miRanda;miRNATAP -0.377153356658342 2.39308058606251e-10 NA NA NA hsa-miR-362-5p IL6ST -0.26647467080141 0.752024885130738 -0.112823587378398 0.902159423718375 mirMAP -0.400659328009239 7.53222597847304e-13 NA NA NA hsa-miR-369-3p IL6ST 0.116576891957687 0.83230082995912 -0.112823587378398 0.902159423718375 mirMAP -0.433425950161765 9.73800093010187e-09 NA NA NA hsa-miR-374b-3p IL6ST -0.0542885924440247 0.860753623992354 -0.112823587378398 0.902159423718375 MirTarget -0.407244423228482 6.76474067103953e-07 NA NA NA hsa-miR-376c-3p IL6ST 0.310149183310886 0.558689295035779 -0.112823587378398 0.902159423718375 mirMAP -0.31224298741464 3.4178053925026e-06 NA NA NA hsa-miR-421 IL6ST -0.182032017078616 0.734704500318599 -0.112823587378398 0.902159423718375 PITA;miRanda;mirMAP -0.350825177257663 8.8070174611515e-07 NA NA NA hsa-miR-429 IL6ST -0.456485631615963 0.806240953400535 -0.112823587378398 0.902159423718375 PITA;miRanda;mirMAP;miRNATAP -0.36035114894059 5.09300442615827e-10 NA NA NA hsa-miR-452-5p IL6ST -0.0504626418153507 0.973874641360401 -0.112823587378398 0.902159423718375 mirMAP -0.238729465476318 0.00104150233672765 NA NA NA hsa-miR-454-3p IL6ST -0.101514866328011 0.843545158256191 -0.112823587378398 0.902159423718375 mirMAP;miRNATAP -0.480562365411181 5.6822531485519e-08 NA NA NA hsa-miR-491-3p IL6ST -0.513850326596847 0.137836285146052 -0.112823587378398 0.902159423718375 mirMAP -0.258378512080082 4.05103466547317e-05 NA NA NA hsa-miR-501-5p IL6ST -0.834032628506285 0.0582725160418523 -0.112823587378398 0.902159423718375 mirMAP -0.298638114825453 5.82370105940243e-08 NA NA NA hsa-miR-505-3p IL6ST -0.469094267152605 0.690382680489578 -0.112823587378398 0.902159423718375 MirTarget -0.626093175995935 6.05451454087051e-13 NA NA NA hsa-miR-532-5p IL6ST -0.349665553500088 0.878948352437467 -0.112823587378398 0.902159423718375 PITA -0.320888745509193 1.84914316135913e-05 NA NA NA hsa-miR-576-5p IL6ST -0.506413219377403 0.417187951364173 -0.112823587378398 0.902159423718375 mirMAP -0.383499085167766 2.59263422816187e-07 NA NA NA hsa-miR-577 IL6ST -1.06238199218774 0.326056761787754 -0.112823587378398 0.902159423718375 MirTarget -0.19328016857286 5.91711880435359e-07 NA NA NA hsa-miR-582-5p IL6ST -0.399450205475138 0.581227478860085 -0.112823587378398 0.902159423718375 mirMAP -0.220882668080716 0.00726467928069098 NA NA NA hsa-miR-589-3p IL6ST -0.835836305204965 0.0112001563801511 -0.112823587378398 0.902159423718375 mirMAP -0.196393638091035 0.000835098263374097 NA NA NA hsa-miR-590-3p IL6ST -0.279244755376859 0.59126669933662 -0.112823587378398 0.902159423718375 miRNAWalker2_validate;miRanda;mirMAP;miRNATAP -0.397571412088194 6.81080807577945e-11 NA NA NA hsa-miR-590-5p IL6ST -0.547819833829572 0.472735645776647 -0.112823587378398 0.902159423718375 mirMAP -0.546184200298782 1.28511163310073e-18 NA NA NA hsa-miR-592 IL6ST -0.177670083168544 0.856226890424691 -0.112823587378398 0.902159423718375 PITA -0.146014139727321 3.44443403532163e-06 NA NA NA hsa-miR-629-3p IL6ST -0.495402745812008 0.333967382214384 -0.112823587378398 0.902159423718375 miRNATAP -0.229396229669438 0.000148406449808887 NA NA NA hsa-miR-7-1-3p IL6ST -0.462485777435991 0.665899751398166 -0.112823587378398 0.902159423718375 mirMAP -0.28434545776091 0.000112889935213401 NA NA NA hsa-miR-93-3p IL6ST -0.438355548962673 0.549902689385444 -0.112823587378398 0.902159423718375 MirTarget -0.427253554664464 1.99681322774585e-09 NA NA NA hsa-miR-126-5p IL7R 0.0815213541035824 0.956637332055185 -0.627859794552579 0.295298335743483 mirMAP -0.4756907745373 0.00657032601364036 NA NA NA hsa-miR-26b-5p IL7R -0.0245931278499594 0.990377966314923 -0.627859794552579 0.295298335743483 miRNAWalker2_validate -0.870942517484309 1.07879495037811e-06 NA NA NA hsa-miR-335-3p IL7R -0.244830745789445 0.88450019116631 -0.627859794552579 0.295298335743483 mirMAP -0.442565943876017 0.000333568517152847 NA NA NA hsa-miR-501-5p IL7R -0.834032628506285 0.0582725160418523 -0.627859794552579 0.295298335743483 mirMAP -0.311813185428204 0.00199338402988381 NA NA NA hsa-miR-576-5p IL7R -0.506413219377403 0.417187951364173 -0.627859794552579 0.295298335743483 mirMAP -0.400800086526563 0.00323100563379795 NA NA NA hsa-miR-590-3p IL7R -0.279244755376859 0.59126669933662 -0.627859794552579 0.295298335743483 miRanda;mirMAP -0.456236486250003 4.92453207211017e-05 NA NA NA hsa-miR-7-1-3p IL7R -0.462485777435991 0.665899751398166 -0.627859794552579 0.295298335743483 mirMAP -0.4009588706607 0.00253474287499519 NA NA NA hsa-miR-17-5p IRF9 -0.175448849583061 0.934544015912731 -0.202509260139889 0.880098511386286 TargetScan -0.145769501366497 0.000898159331588594 NA NA NA hsa-miR-106b-5p JAK1 -0.297128724729339 0.869294443540749 -0.160789648998376 0.924345663738973 miRNAWalker2_validate;MirTarget -0.167053872986828 2.36141799268953e-05 NA NA NA hsa-miR-17-5p JAK1 -0.175448849583061 0.934544015912731 -0.160789648998376 0.924345663738973 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.134849334407276 7.10169984665729e-06 NA NA NA hsa-miR-20a-5p JAK1 -0.179153323927949 0.928118119139752 -0.160789648998376 0.924345663738973 MirTarget -0.116475297641578 9.02100787767039e-05 NA NA NA hsa-miR-421 JAK1 -0.182032017078616 0.734704500318599 -0.160789648998376 0.924345663738973 miRanda -0.119739376769396 0.000300534389828812 NA NA NA hsa-miR-93-5p JAK1 -0.611073677204699 0.825297877093193 -0.160789648998376 0.924345663738973 MirTarget;miRNATAP -0.109587302887753 0.00369025117895739 NA NA NA hsa-miR-193a-3p JAK2 -0.247265785363732 0.654363581941634 -0.315139147716286 0.737125845139285 miRanda -0.211938768285493 7.66190655468735e-05 NA NA NA hsa-miR-335-5p JAK2 -0.0284895175847679 0.973380867832231 -0.315139147716286 0.737125845139285 miRNAWalker2_validate -0.270984786052004 1.50549710775928e-07 NA NA NA hsa-miR-337-3p JAK2 0.226996212439783 0.815575855239318 -0.315139147716286 0.737125845139285 PITA -0.227674822763369 0.000908851990873021 NA NA NA hsa-miR-374a-5p JAK2 -0.343007247142618 0.766921280269271 -0.315139147716286 0.737125845139285 mirMAP -0.398285334749025 8.53488451380717e-07 NA NA NA hsa-miR-374b-5p JAK2 -0.285682091626878 0.83569830479965 -0.315139147716286 0.737125845139285 mirMAP -0.440177014886739 1.50417600914702e-08 NA NA NA hsa-miR-335-5p JAK3 -0.0284895175847679 0.973380867832231 -0.063598471066431 0.939287138619009 miRNAWalker2_validate -0.251562484181648 2.3085400788056e-05 NA NA NA hsa-miR-339-5p JAK3 -0.300425087100667 0.712912847076788 -0.063598471066431 0.939287138619009 miRanda -0.156762150394825 0.00353052959123591 NA NA NA hsa-miR-939-5p JAK3 -0.311196961912953 0.304447903545905 -0.063598471066431 0.939287138619009 MirTarget -0.198408127454438 0.000550081343185762 NA NA NA hsa-miR-130b-5p LEP -0.6472141103776 0.379096015222509 0.633209008302639 0.565467209753707 mirMAP -0.835375736211168 1.27935219613486e-07 NA NA NA hsa-miR-221-5p LEP 0.0797468413208215 0.897597103192104 0.633209008302639 0.565467209753707 mirMAP -0.370632728577516 0.00268401017425819 NA NA NA hsa-miR-27b-5p LEP -0.331337007788532 0.686623472774964 0.633209008302639 0.565467209753707 mirMAP -0.766606055290281 0.00139195674329636 NA NA NA hsa-miR-29a-3p LEP 0.01127474410284 0.996977020481272 0.633209008302639 0.565467209753707 miRNATAP -0.639408195777951 0.00352898146776763 NA NA NA hsa-miR-29b-3p LEP -0.104016192263954 0.958988036765397 0.633209008302639 0.565467209753707 miRNATAP -0.680691198593961 3.45113035379086e-05 NA NA NA hsa-miR-335-3p LEP -0.244830745789445 0.88450019116631 0.633209008302639 0.565467209753707 mirMAP -0.481997576092726 0.00151125087411722 NA NA NA hsa-miR-33a-3p LEP -0.794543849238581 0.0105203072007922 0.633209008302639 0.565467209753707 mirMAP -0.580001257918355 3.36573184466662e-05 NA NA NA hsa-miR-375 LEP -0.690952835064582 0.831716365337668 0.633209008302639 0.565467209753707 mirMAP -0.38870576082052 0.000219171468668013 NA NA NA hsa-miR-590-3p LEP -0.279244755376859 0.59126669933662 0.633209008302639 0.565467209753707 mirMAP -0.586912333183301 2.03200853843048e-05 NA NA NA hsa-let-7a-3p LEPR -0.215598045625677 0.85543299203799 0.642200122826726 0.284902873327859 mirMAP -0.222152295467266 0.00453719470781161 NA NA NA hsa-let-7f-1-3p LEPR -0.31101436822914 0.693407210545374 0.642200122826726 0.284902873327859 mirMAP -0.370816699336283 0.00049073172522009 NA NA NA hsa-miR-130b-5p LEPR -0.6472141103776 0.379096015222509 0.642200122826726 0.284902873327859 mirMAP -0.389644279624292 4.64543094960458e-09 NA NA NA hsa-miR-16-1-3p LEPR 0.151694812889216 0.733736501874638 0.642200122826726 0.284902873327859 mirMAP -0.227985983059342 0.000228742453959635 NA NA NA hsa-miR-16-2-3p LEPR -0.36717860153421 0.546850726070016 0.642200122826726 0.284902873327859 mirMAP -0.315973623698122 6.97813899982955e-07 NA NA NA hsa-miR-29a-5p LEPR -0.31835175571979 0.600442757817281 0.642200122826726 0.284902873327859 mirMAP -0.338569234990617 7.89540828742251e-08 NA NA NA hsa-miR-320a LEPR -0.416546433767628 0.840202138616422 0.642200122826726 0.284902873327859 miRanda -0.235459706439501 0.00520404497410861 NA NA NA hsa-miR-335-3p LEPR -0.244830745789445 0.88450019116631 0.642200122826726 0.284902873327859 mirMAP -0.310649457706094 9.33164091569985e-07 NA NA NA hsa-miR-33a-3p LEPR -0.794543849238581 0.0105203072007922 0.642200122826726 0.284902873327859 mirMAP -0.253309107644529 1.8479032395703e-05 NA NA NA hsa-miR-362-3p LEPR -0.721040238345347 0.0345881362485733 0.642200122826726 0.284902873327859 miRanda -0.241692190461201 2.12436291469666e-05 NA NA NA hsa-miR-421 LEPR -0.182032017078616 0.734704500318599 0.642200122826726 0.284902873327859 miRanda -0.316406214237822 2.01353663953436e-06 NA NA NA hsa-miR-429 LEPR -0.456485631615963 0.806240953400535 0.642200122826726 0.284902873327859 miRanda;miRNATAP -0.24855157412061 6.48647480736883e-06 NA NA NA hsa-miR-576-5p LEPR -0.506413219377403 0.417187951364173 0.642200122826726 0.284902873327859 PITA -0.382577171269937 2.97991192129153e-08 NA NA NA hsa-miR-590-3p LEPR -0.279244755376859 0.59126669933662 0.642200122826726 0.284902873327859 miRanda;mirMAP -0.304772582100387 1.27139186735866e-07 NA NA NA hsa-miR-590-5p LEPR -0.547819833829572 0.472735645776647 0.642200122826726 0.284902873327859 miRanda -0.438032150283432 1.39349429627842e-13 NA NA NA hsa-miR-660-5p LEPR -0.476129334484339 0.694082832658925 0.642200122826726 0.284902873327859 MirTarget -0.366303636235797 2.66295828907021e-07 NA NA NA hsa-miR-7-1-3p LEPR -0.462485777435991 0.665899751398166 0.642200122826726 0.284902873327859 mirMAP -0.247671171345817 0.00031490675245296 NA NA NA hsa-miR-877-5p LEPR -0.317720731672575 0.435952264022643 0.642200122826726 0.284902873327859 miRNAWalker2_validate -0.193877504956883 0.000150463783206501 NA NA NA hsa-miR-181c-5p LIF 0.042951891660695 0.969159991881861 0.179197549253749 0.880322734290608 miRNATAP -0.207466305775409 0.00378940402818305 NA NA NA hsa-miR-335-5p LIF -0.0284895175847679 0.973380867832231 0.179197549253749 0.880322734290608 miRNAWalker2_validate;mirMAP -0.17366727282129 0.00568227209856928 NA NA NA hsa-let-7a-3p LIFR -0.215598045625677 0.85543299203799 0.297225879773933 0.536497058727362 mirMAP -0.672277431183378 1.66141312929081e-08 NA NA NA hsa-let-7f-1-3p LIFR -0.31101436822914 0.693407210545374 0.297225879773933 0.536497058727362 mirMAP -0.849682845542626 2.03668668626236e-07 NA NA NA hsa-miR-126-5p LIFR 0.0815213541035824 0.956637332055185 0.297225879773933 0.536497058727362 mirMAP -0.447200366181913 0.00161572479473956 NA NA NA hsa-miR-128-3p LIFR -0.442192625156042 0.783886533572187 0.297225879773933 0.536497058727362 miRNAWalker2_validate -1.08526364595898 4.3362393695362e-16 NA NA NA hsa-miR-1296-5p LIFR -0.639266760267726 0.236989089559211 0.297225879773933 0.536497058727362 miRNAWalker2_validate -0.402993375927165 9.02521496990703e-05 NA NA NA hsa-miR-142-3p LIFR -0.154235241441331 0.946098054588918 0.297225879773933 0.536497058727362 miRNATAP -0.265083588193819 0.00332351278503145 NA NA NA hsa-miR-144-3p LIFR 0.0482420655617901 0.935871997593533 0.297225879773933 0.536497058727362 miRNATAP -0.27523532502858 3.53888625560761e-05 NA NA NA hsa-miR-148a-5p LIFR -0.448099743845604 0.748419139652266 0.297225879773933 0.536497058727362 mirMAP -0.557909845710195 1.95961200792084e-07 NA NA NA hsa-miR-182-5p LIFR -0.104238497940557 0.973380614062243 0.297225879773933 0.536497058727362 mirMAP -0.436557387321679 5.43107281243709e-06 NA NA NA hsa-miR-186-5p LIFR -0.318786974828757 0.85412722938961 0.297225879773933 0.536497058727362 mirMAP -1.02450384379999 5.15784124353141e-12 NA NA NA hsa-miR-19a-3p LIFR -0.206793507801887 0.844637784802316 0.297225879773933 0.536497058727362 mirMAP -0.728526717622814 1.70914130403933e-17 NA NA NA hsa-miR-19b-3p LIFR -0.0268530183621474 0.986656783046572 0.297225879773933 0.536497058727362 mirMAP -0.808224472995416 6.42984269984657e-15 NA NA NA hsa-miR-203a-3p LIFR -0.265248086637561 0.931593594361942 0.297225879773933 0.536497058727362 MirTarget -0.512755201069963 9.59292261334022e-11 NA NA NA hsa-miR-21-5p LIFR -0.148920887107433 0.970240620972126 0.297225879773933 0.536497058727362 miRNAWalker2_validate -0.716468263704045 0.000112530606449515 NA NA NA hsa-miR-221-3p LIFR 0.0906940388127513 0.959121118272534 0.297225879773933 0.536497058727362 miRNATAP -0.846000067061353 1.16646321764849e-10 NA NA NA hsa-miR-222-3p LIFR -0.0265849318772702 0.984005474689108 0.297225879773933 0.536497058727362 miRNATAP -0.887267241701075 1.34559387971847e-14 NA NA NA hsa-miR-23a-3p LIFR -0.122198715333656 0.962717452143511 0.297225879773933 0.536497058727362 mirMAP -0.903403510571272 7.92205134324766e-06 NA NA NA hsa-miR-26b-5p LIFR -0.0245931278499594 0.990377966314923 0.297225879773933 0.536497058727362 mirMAP -0.83746113863012 5.32634860907294e-09 NA NA NA hsa-miR-27a-3p LIFR -0.123902317731458 0.958804393510999 0.297225879773933 0.536497058727362 miRNAWalker2_validate;MirTarget;miRNATAP -1.05118712583523 8.05733254381539e-10 NA NA NA hsa-miR-29b-1-5p LIFR -0.642348119412534 0.293891497238796 0.297225879773933 0.536497058727362 mirMAP -0.645899085946252 6.84345660044448e-19 NA NA NA hsa-miR-30c-1-3p LIFR -0.202466672579761 0.511485842123022 0.297225879773933 0.536497058727362 MirTarget -0.357486054324478 0.00015117359662479 NA NA NA hsa-miR-30c-5p LIFR -0.298383882401475 0.865809030482001 0.297225879773933 0.536497058727362 miRNATAP -0.491472607521247 0.00155635346657659 NA NA NA hsa-miR-30d-3p LIFR -0.123474741320298 0.814905367625791 0.297225879773933 0.536497058727362 mirMAP -0.782437233512252 3.68128765832403e-11 NA NA NA hsa-miR-32-3p LIFR -0.568003960723004 0.13133163420273 0.297225879773933 0.536497058727362 mirMAP -0.565336150455569 8.64980255243896e-14 NA NA NA hsa-miR-335-3p LIFR -0.244830745789445 0.88450019116631 0.297225879773933 0.536497058727362 MirTarget -0.625461986164295 1.17651955240074e-10 NA NA NA hsa-miR-335-5p LIFR -0.0284895175847679 0.973380867832231 0.297225879773933 0.536497058727362 miRNAWalker2_validate -0.461711916417873 3.63316666763131e-06 NA NA NA hsa-miR-374a-3p LIFR -0.118320910531011 0.958176637009264 0.297225879773933 0.536497058727362 miRNATAP -0.325016257794979 0.00324501444948357 NA NA NA hsa-miR-421 LIFR -0.182032017078616 0.734704500318599 0.297225879773933 0.536497058727362 mirMAP -0.516527633021936 6.52651869158383e-07 NA NA NA hsa-miR-429 LIFR -0.456485631615963 0.806240953400535 0.297225879773933 0.536497058727362 miRanda -0.680710530650841 7.19102300563306e-17 NA NA NA hsa-miR-500a-5p LIFR -0.71978560736831 0.188073776225276 0.297225879773933 0.536497058727362 mirMAP -0.548263629999614 2.10784976291478e-09 NA NA NA hsa-miR-577 LIFR -1.06238199218774 0.326056761787754 0.297225879773933 0.536497058727362 mirMAP -0.466857781973743 1.74468996611154e-18 NA NA NA hsa-miR-590-3p LIFR -0.279244755376859 0.59126669933662 0.297225879773933 0.536497058727362 miRanda;mirMAP -0.649706312753 1.12428618636646e-13 NA NA NA hsa-miR-590-5p LIFR -0.547819833829572 0.472735645776647 0.297225879773933 0.536497058727362 PITA;miRNATAP -0.808429122901963 2.62637349813275e-19 NA NA NA hsa-miR-629-3p LIFR -0.495402745812008 0.333967382214384 0.297225879773933 0.536497058727362 miRNATAP -0.552469647923073 9.70967067502951e-11 NA NA NA hsa-miR-7-1-3p LIFR -0.462485777435991 0.665899751398166 0.297225879773933 0.536497058727362 mirMAP -0.744031155250213 4.66343624579115e-13 NA NA NA hsa-miR-760 LIFR -0.669469782471462 0.0773517068284613 0.297225879773933 0.536497058727362 MirTarget -0.397000838459872 8.76345629419851e-08 NA NA NA hsa-miR-935 LIFR 0.0536667023984385 0.939418255464024 0.297225879773933 0.536497058727362 PITA -0.224879996962411 1.30011068920498e-06 NA NA NA hsa-miR-940 LIFR -0.225788347550697 0.680055767105815 0.297225879773933 0.536497058727362 MirTarget -0.413417571638746 8.64888494201582e-08 NA NA NA hsa-miR-96-5p LIFR 0.0854810872029343 0.923087820185031 0.297225879773933 0.536497058727362 mirMAP -0.694279029307552 7.96143843810432e-15 NA NA NA hsa-miR-98-5p LIFR -0.168162186023221 0.898802461503524 0.297225879773933 0.536497058727362 miRNAWalker2_validate -0.812094986133908 2.69203700916619e-08 NA NA NA hsa-miR-320b MYC -0.23561798088153 0.859222532827992 -0.445372871610816 0.811492365164222 miRNAWalker2_validate -0.243607030835589 0.000321638494084035 26487644 miR 320b suppresses cell proliferation by targeting c Myc in human colorectal cancer cells; Overexpression of miR-320b in CRC cells was statistically correlated with a decrease of cell growth in vitro and in vivo while c-MYC was identified as a target gene of miR-320b in CRC; Furthermore it was found that up-regulation of c-Myc can attenuate the effects induced by miR-320b; Our identification of c-MYC as a target gene of miR-320b provides new insights into the pathophysiology of CRC proliferation and identifies miR-320b as a novel therapeutic target for the treatment of CRC colorectal cancer hsa-miR-320a OSM -0.416546433767628 0.840202138616422 0.103691819182827 0.857370320646043 miRanda -0.415784695239775 0.00500697105310872 NA NA NA hsa-miR-320b OSM -0.23561798088153 0.859222532827992 0.103691819182827 0.857370320646043 miRanda -0.384912126448891 0.00378887698133171 NA NA NA hsa-miR-590-5p OSM -0.547819833829572 0.472735645776647 0.103691819182827 0.857370320646043 miRanda -0.306364153276096 0.0052331892512604 NA NA NA hsa-miR-592 OSM -0.177670083168544 0.856226890424691 0.103691819182827 0.857370320646043 PITA;miRNATAP -0.237137669046186 4.18378842780268e-06 NA NA NA hsa-let-7d-5p OSMR -0.139747701175051 0.934164162708487 0.00216857550159144 0.997923739247632 miRNATAP -1.07184151663715 6.00910861679442e-10 NA NA NA hsa-let-7f-5p OSMR 0.048789917034723 0.987280455481631 0.00216857550159144 0.997923739247632 miRNATAP -0.44457171804473 0.00933859815437153 NA NA NA hsa-let-7g-5p OSMR -0.200947212961157 0.922992045181955 0.00216857550159144 0.997923739247632 miRNATAP -1.19222774082954 5.12587563574093e-13 NA NA NA hsa-miR-1254 OSMR -0.488929355953681 0.19551794273322 0.00216857550159144 0.997923739247632 MirTarget -0.243454875322682 0.00552273139839542 NA NA NA hsa-miR-140-5p OSMR -0.229213026275906 0.847330111738616 0.00216857550159144 0.997923739247632 miRanda -0.443103270757812 0.00620788358919925 NA NA NA hsa-miR-193a-3p OSMR -0.247265785363732 0.654363581941634 0.00216857550159144 0.997923739247632 MirTarget -0.462314056207244 6.02581189406899e-06 NA NA NA hsa-miR-193b-3p OSMR 0.0672068426635715 0.951480422273678 0.00216857550159144 0.997923739247632 MirTarget -0.326643136707499 0.0014350882627309 NA NA NA hsa-miR-196a-5p OSMR -0.0569856738232488 0.973093117800687 0.00216857550159144 0.997923739247632 miRNATAP -0.373031573939587 4.56224308368547e-09 NA NA NA hsa-miR-196b-5p OSMR -0.0840912027031901 0.972112413910242 0.00216857550159144 0.997923739247632 miRNATAP -0.267627808268696 2.24946543544286e-05 NA NA NA hsa-miR-200b-3p OSMR -0.426401948379212 0.863957108574195 0.00216857550159144 0.997923739247632 TargetScan -0.766740801405702 5.78056820519088e-14 NA NA NA hsa-miR-335-5p OSMR -0.0284895175847679 0.973380867832231 0.00216857550159144 0.997923739247632 miRNAWalker2_validate -0.804135889957567 1.24599716554332e-17 NA NA NA hsa-miR-362-3p OSMR -0.721040238345347 0.0345881362485733 0.00216857550159144 0.997923739247632 miRanda -0.498074042481894 1.17761277129869e-08 NA NA NA hsa-miR-374a-5p OSMR -0.343007247142618 0.766921280269271 0.00216857550159144 0.997923739247632 mirMAP -0.651406063414268 3.06926852708041e-05 NA NA NA hsa-miR-374b-5p OSMR -0.285682091626878 0.83569830479965 0.00216857550159144 0.997923739247632 mirMAP -0.903856112723366 1.06191708297857e-09 NA NA NA hsa-miR-429 OSMR -0.456485631615963 0.806240953400535 0.00216857550159144 0.997923739247632 miRanda;miRNATAP -0.689001426037846 2.34458971033647e-17 NA NA NA hsa-miR-548o-3p OSMR -0.191447572716994 0.517725546183501 0.00216857550159144 0.997923739247632 MirTarget -0.304670977491603 0.0024799725697717 NA NA NA hsa-miR-590-3p OSMR -0.279244755376859 0.59126669933662 0.00216857550159144 0.997923739247632 miRanda;mirMAP;miRNATAP -0.679900270729969 4.79037887247072e-15 NA NA NA hsa-miR-98-5p OSMR -0.168162186023221 0.898802461503524 0.00216857550159144 0.997923739247632 miRNAWalker2_validate -0.65184790597328 1.02842987099591e-05 NA NA NA hsa-miR-181c-5p PIAS2 0.042951891660695 0.969159991881861 -0.490389692026203 0.469210208589493 mirMAP -0.192837330224965 1.72578986028903e-05 NA NA NA hsa-miR-193a-3p PIAS2 -0.247265785363732 0.654363581941634 -0.490389692026203 0.469210208589493 MirTarget -0.172733886997519 1.78592113631722e-05 NA NA NA hsa-miR-193b-3p PIAS2 0.0672068426635715 0.951480422273678 -0.490389692026203 0.469210208589493 MirTarget -0.13695466022186 0.000663173817351655 NA NA NA hsa-miR-224-3p PIAS2 0.110372723153393 0.749091467231007 -0.490389692026203 0.469210208589493 mirMAP -0.138675066910832 5.29997875171792e-05 NA NA NA hsa-miR-32-5p PIAS2 -0.05993267619119 0.952975951594959 -0.490389692026203 0.469210208589493 mirMAP -0.114469832881681 0.00701152685681355 NA NA NA hsa-miR-362-5p PIAS2 -0.26647467080141 0.752024885130738 -0.490389692026203 0.469210208589493 TargetScan -0.107874398355399 0.00126280217699544 NA NA NA hsa-miR-424-5p PIAS2 0.247080963500746 0.870154571783568 -0.490389692026203 0.469210208589493 MirTarget -0.11370654039815 0.00168446474012252 NA NA NA hsa-miR-92a-3p PIAS2 0.0278830870766349 0.993247426671713 -0.490389692026203 0.469210208589493 mirMAP -0.143477229887535 0.00127755078931003 NA NA NA hsa-miR-1275 PIAS3 -0.831342050607648 0.0803795852164229 0.102331021787322 0.920637784565949 MirTarget -0.105881504551777 2.31788392864969e-05 NA NA NA hsa-miR-181c-5p PIAS3 0.042951891660695 0.969159991881861 0.102331021787322 0.920637784565949 miRNATAP -0.110793875884595 0.00847529932068527 NA NA NA hsa-miR-18a-5p PIAS3 -0.498318455303917 0.61264091975585 0.102331021787322 0.920637784565949 MirTarget -0.16668384221433 5.32964928646184e-09 27198161 Further functional experiments indicate that CASC2 could directly upregulate PIAS3 expression by functioning as a competing endogenous RNA ceRNA for miR-18a colorectal cancer hsa-miR-532-3p PIAS3 -0.496590111092324 0.682889021782543 0.102331021787322 0.920637784565949 miRNATAP -0.174627876342867 8.90931242899641e-07 NA NA NA hsa-let-7f-1-3p PIK3CA -0.31101436822914 0.693407210545374 0.0225357621933919 0.979422693316883 mirMAP -0.118501081655342 0.0064771514178073 NA NA NA hsa-miR-148a-5p PIK3CA -0.448099743845604 0.748419139652266 0.0225357621933919 0.979422693316883 mirMAP -0.112357517651492 7.06215647986463e-05 NA NA NA hsa-miR-148b-3p PIK3CA -0.202106692287125 0.911884960581838 0.0225357621933919 0.979422693316883 miRNAWalker2_validate -0.117892096365902 0.00490902202717801 NA NA NA hsa-miR-16-2-3p PIK3CA -0.36717860153421 0.546850726070016 0.0225357621933919 0.979422693316883 mirMAP -0.10245614796563 9.13897985797286e-05 NA NA NA hsa-miR-17-5p PIK3CA -0.175448849583061 0.934544015912731 0.0225357621933919 0.979422693316883 miRNAWalker2_validate -0.115705723770344 3.03228335548689e-06 NA NA NA hsa-miR-186-5p PIK3CA -0.318786974828757 0.85412722938961 0.0225357621933919 0.979422693316883 mirMAP -0.146329134056921 0.000268937701971312 NA NA NA hsa-miR-32-3p PIK3CA -0.568003960723004 0.13133163420273 0.0225357621933919 0.979422693316883 mirMAP -0.112972746252127 2.51225612643757e-08 NA NA NA hsa-miR-335-5p PIK3CA -0.0284895175847679 0.973380867832231 0.0225357621933919 0.979422693316883 miRNAWalker2_validate -0.10180509768488 9.82755134026126e-05 NA NA NA hsa-miR-339-5p PIK3CA -0.300425087100667 0.712912847076788 0.0225357621933919 0.979422693316883 miRanda -0.103587269763801 8.44655068921029e-06 NA NA NA hsa-miR-374b-5p PIK3CA -0.285682091626878 0.83569830479965 0.0225357621933919 0.979422693316883 mirMAP -0.142766383581644 0.00032150800529493 NA NA NA hsa-miR-501-5p PIK3CA -0.834032628506285 0.0582725160418523 0.0225357621933919 0.979422693316883 mirMAP -0.110757579310586 1.16330645525834e-07 NA NA NA hsa-miR-576-5p PIK3CA -0.506413219377403 0.417187951364173 0.0225357621933919 0.979422693316883 PITA -0.113974010997229 6.59094941020168e-05 NA NA NA hsa-miR-582-3p PIK3CA -0.2334649592375 0.897678119160318 0.0225357621933919 0.979422693316883 miRNATAP -0.140113361530972 2.23178585157338e-06 NA NA NA hsa-miR-590-3p PIK3CA -0.279244755376859 0.59126669933662 0.0225357621933919 0.979422693316883 miRanda;mirMAP -0.123897140594567 1.31301452772078e-07 NA NA NA hsa-miR-590-5p PIK3CA -0.547819833829572 0.472735645776647 0.0225357621933919 0.979422693316883 miRanda -0.140125048782077 1.41706046141534e-08 NA NA NA hsa-miR-96-5p PIK3CA 0.0854810872029343 0.923087820185031 0.0225357621933919 0.979422693316883 TargetScan -0.128475980855667 9.81905908048452e-08 NA NA NA hsa-miR-1468-5p PIK3CD -0.200868572236891 0.688408103178562 -0.0499659666229988 0.947033498136668 MirTarget -0.293090508926218 0.000248785469894942 NA NA NA hsa-miR-29a-3p PIK3CD 0.01127474410284 0.996977020481272 -0.0499659666229988 0.947033498136668 mirMAP -0.351166771873915 0.00243536234086878 NA NA NA hsa-miR-29b-3p PIK3CD -0.104016192263954 0.958988036765397 -0.0499659666229988 0.947033498136668 mirMAP -0.263613715224296 0.00266331795083224 NA NA NA hsa-miR-30b-5p PIK3CD -0.0121430518253582 0.994622896704513 -0.0499659666229988 0.947033498136668 MirTarget -0.395682674717868 3.65190942130723e-06 NA NA NA hsa-miR-30c-5p PIK3CD -0.298383882401475 0.865809030482001 -0.0499659666229988 0.947033498136668 MirTarget;miRNATAP -0.419452305097446 0.000712699686404817 NA NA NA hsa-miR-30d-5p PIK3CD -0.168211838771867 0.95173197030375 -0.0499659666229988 0.947033498136668 MirTarget;miRNATAP -0.360885227262785 0.00123008895505406 NA NA NA hsa-miR-421 PIK3CD -0.182032017078616 0.734704500318599 -0.0499659666229988 0.947033498136668 miRanda -0.48895286723391 2.44692621373687e-09 NA NA NA hsa-miR-484 PIK3CD -0.179977202691249 0.886333755572375 -0.0499659666229988 0.947033498136668 MirTarget;miRNATAP -0.351057480112147 0.00143452196121959 NA NA NA hsa-miR-7-5p PIK3CD 0.209645143210379 0.773705612298441 -0.0499659666229988 0.947033498136668 miRTarBase;MirTarget;miRNATAP -0.196228010352377 0.000352590199023202 22234835 We first screened and identified a novel miR-7 target phosphoinositide 3-kinase catalytic subunit delta PIK3CD; A correlation between miR-7 and PIK3CD expression was also confirmed in clinical samples of HCC; By targeting PIK3CD mTOR and p70S6K miR-7 efficiently regulates the PI3K/Akt pathway liver cancer hsa-miR-942-5p PIK3CD -0.50502396741886 0.50777904281306 -0.0499659666229988 0.947033498136668 MirTarget -0.192312219113083 0.0086308226579878 NA NA NA hsa-miR-126-3p PIK3CG -0.106293136341574 0.963670566555251 -0.358088978987777 0.469718116584845 miRTarBase -0.534372493039168 0.000484031176443627 NA NA NA hsa-miR-26b-5p PIK3CG -0.0245931278499594 0.990377966314923 -0.358088978987777 0.469718116584845 miRNAWalker2_validate -0.795245028298382 7.45064172731532e-07 NA NA NA hsa-miR-29b-3p PIK3CG -0.104016192263954 0.958988036765397 -0.358088978987777 0.469718116584845 miRTarBase -0.666133284835925 1.9528746633095e-08 NA NA NA hsa-miR-335-3p PIK3CG -0.244830745789445 0.88450019116631 -0.358088978987777 0.469718116584845 mirMAP -0.563949149516835 2.51672261116185e-07 NA NA NA hsa-miR-421 PIK3CG -0.182032017078616 0.734704500318599 -0.358088978987777 0.469718116584845 miRanda -0.444524915857051 0.000133233454665448 NA NA NA hsa-miR-502-5p PIK3CG -0.708507838520586 0.0261309781860104 -0.358088978987777 0.469718116584845 miRNATAP -0.340480467784473 0.000652722824953133 26163264 Phosphoinositide 3-kinase catalytic subunit gamma PIK3CG was identified as a direct downstream target of miR-502 in HCC cells; Notably overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells liver cancer hsa-miR-590-3p PIK3CG -0.279244755376859 0.59126669933662 -0.358088978987777 0.469718116584845 miRanda -0.438492197588501 1.39596666922937e-05 NA NA NA hsa-miR-132-3p PIK3R1 -0.244143673573889 0.871752726220643 -0.107670470040419 0.937523599303491 MirTarget -0.191363026291576 0.00729852053203983 NA NA NA hsa-miR-15a-5p PIK3R1 -0.0674049094129128 0.964835434214123 -0.107670470040419 0.937523599303491 MirTarget -0.217108462406312 8.91731617861317e-05 NA NA NA hsa-miR-15b-5p PIK3R1 -0.272614787130877 0.87096541832188 -0.107670470040419 0.937523599303491 MirTarget -0.14300320532504 0.00643583854060318 NA NA NA hsa-miR-16-5p PIK3R1 0.0135949734723564 0.994476223855607 -0.107670470040419 0.937523599303491 MirTarget -0.189731088951203 0.0002621971143127 NA NA NA hsa-miR-185-5p PIK3R1 -0.294432218239008 0.820591478398594 -0.107670470040419 0.937523599303491 miRNATAP -0.23627908813405 0.00027005032337405 NA NA NA hsa-miR-21-5p PIK3R1 -0.148920887107433 0.970240620972126 -0.107670470040419 0.937523599303491 miRNAWalker2_validate;MirTarget;miRNATAP -0.32048586087571 3.69693869528844e-05 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 -0.0224067199236484 0.973232008101458 -0.107670470040419 0.937523599303491 MirTarget -0.229364822725893 5.39528810633945e-05 NA NA NA hsa-miR-22-5p PIK3R1 -0.0785922550675187 0.93169760098231 -0.107670470040419 0.937523599303491 mirMAP -0.186145388676108 2.66965799007355e-05 NA NA NA hsa-miR-221-3p PIK3R1 0.0906940388127513 0.959121118272534 -0.107670470040419 0.937523599303491 MirTarget -0.197435928682178 0.000527618156345501 NA NA NA hsa-miR-222-3p PIK3R1 -0.0265849318772702 0.984005474689108 -0.107670470040419 0.937523599303491 MirTarget -0.202803725155249 6.41878654683067e-05 NA NA NA hsa-miR-369-3p PIK3R1 0.116576891957687 0.83230082995912 -0.107670470040419 0.937523599303491 PITA -0.167895129809982 0.000380018195201003 NA NA NA hsa-miR-424-5p PIK3R1 0.247080963500746 0.870154571783568 -0.107670470040419 0.937523599303491 MirTarget -0.119382000204097 0.00203768025896863 NA NA NA hsa-miR-450b-5p PIK3R1 -0.0136687538973108 0.983149761399849 -0.107670470040419 0.937523599303491 miRNATAP -0.190787246019265 6.82791616588e-05 NA NA NA hsa-miR-542-3p PIK3R1 0.188168046511374 0.909252939431573 -0.107670470040419 0.937523599303491 MirTarget;PITA;miRanda -0.150969723974234 0.00748950466389255 NA NA NA hsa-miR-582-5p PIK3R1 -0.399450205475138 0.581227478860085 -0.107670470040419 0.937523599303491 mirMAP -0.142451077115944 0.0045721005781701 NA NA NA hsa-miR-590-3p PIK3R1 -0.279244755376859 0.59126669933662 -0.107670470040419 0.937523599303491 miRanda;mirMAP -0.146401290926594 0.000138874186663878 NA NA NA hsa-miR-590-5p PIK3R1 -0.547819833829572 0.472735645776647 -0.107670470040419 0.937523599303491 MirTarget;PITA;miRanda;miRNATAP -0.15721405103923 0.000108223764424085 NA NA NA hsa-miR-30a-5p PIK3R2 0.219472325612346 0.933954023293816 -0.297680606771329 0.850152230341952 miRNATAP -0.205862820761505 5.83465711487357e-06 NA NA NA hsa-miR-181c-5p PIK3R3 0.042951891660695 0.969159991881861 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.166375015135553 0.00307339705460455 NA NA NA hsa-miR-181d-5p PIK3R3 0.14926527647499 0.888000971478017 -0.276772749610974 0.793454902449853 MirTarget -0.160008098502222 0.000261018045617695 NA NA NA hsa-miR-19a-3p PIK3R3 -0.206793507801887 0.844637784802316 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.116147528359031 0.00952170048888319 NA NA NA hsa-miR-19b-3p PIK3R3 -0.0268530183621474 0.986656783046572 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.194729521448902 0.000250390771046988 NA NA NA hsa-miR-32-5p PIK3R3 -0.05993267619119 0.952975951594959 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.138065839958076 0.00869251602983598 NA NA NA hsa-miR-335-3p PIK3R3 -0.244830745789445 0.88450019116631 -0.276772749610974 0.793454902449853 mirMAP -0.200911178812086 3.4951167686824e-05 NA NA NA hsa-miR-339-5p PIK3R3 -0.300425087100667 0.712912847076788 -0.276772749610974 0.793454902449853 MirTarget;miRanda -0.114440753951127 0.00949514702310638 NA NA NA hsa-miR-454-3p PIK3R3 -0.101514866328011 0.843545158256191 -0.276772749610974 0.793454902449853 mirMAP -0.183582040707033 0.00426750044797469 NA NA NA hsa-miR-92a-3p PIK3R3 0.0278830870766349 0.993247426671713 -0.276772749610974 0.793454902449853 MirTarget;miRNATAP -0.264671393069774 1.12229021521678e-06 NA NA NA hsa-miR-182-5p PIK3R5 -0.104238497940557 0.973380614062243 -0.266913830275555 0.638823741545427 MirTarget -0.335738588315792 0.000137422868989864 NA NA NA hsa-miR-18a-3p PIK3R5 -0.270443061178857 0.535291623032886 -0.266913830275555 0.638823741545427 MirTarget -0.247792416366587 0.000674544930154222 NA NA NA hsa-miR-183-5p PIM1 -0.0549974865878067 0.984855271688809 0.516930889328276 0.687958324926977 miRNATAP -0.185791621852883 1.64824437472669e-05 NA NA NA hsa-miR-335-5p PIM1 -0.0284895175847679 0.973380867832231 0.516930889328276 0.687958324926977 miRNAWalker2_validate -0.144174992454742 0.00232658099928773 NA NA NA hsa-let-7i-5p PRLR -0.200792135853451 0.922018647874073 0.130677603725213 0.899460261123997 miRNATAP -0.749086546015199 7.28886173382936e-05 NA NA NA hsa-miR-146b-5p PRLR -0.402662509440887 0.837510937985091 0.130677603725213 0.899460261123997 mirMAP -0.620798089288789 1.01733730833539e-07 NA NA NA hsa-miR-455-5p PRLR -0.139599153671262 0.865744220236311 0.130677603725213 0.899460261123997 miRanda -0.286241336399817 0.00715002502062815 NA NA NA hsa-miR-34c-5p PTPN11 -0.018707656771723 0.952788306178575 -0.147331564107356 0.929664645919991 miRanda -0.102977856144078 0.000100612447365417 NA NA NA hsa-miR-130b-5p SOCS2 -0.6472141103776 0.379096015222509 0.103547594378292 0.888418334356555 miRNATAP -0.192226617246216 0.00272392200698522 NA NA NA hsa-miR-186-5p SOCS2 -0.318786974828757 0.85412722938961 0.103547594378292 0.888418334356555 mirMAP -0.273664309203801 0.00325000338416341 NA NA NA hsa-miR-194-5p SOCS2 -0.159001168846464 0.959682382557336 0.103547594378292 0.888418334356555 miRNAWalker2_validate;miRTarBase;miRNATAP -0.169496916135364 0.00527209306977598 22102710 Functional studies indicated that CDKN1A/p21 and SOCS2 expression is directly regulated by miR-20a/-20b and miR-194 respectively; miR-20a/b and miR-194 target CDKN1A and SOCS2 in follicular lymphoma potentially contributing to tumor cell proliferation and survival poor survival lymphoma hsa-miR-19a-3p SOCS2 -0.206793507801887 0.844637784802316 0.103547594378292 0.888418334356555 mirMAP -0.153564622491326 0.00535277458362408 NA NA NA hsa-miR-32-5p SOCS2 -0.05993267619119 0.952975951594959 0.103547594378292 0.888418334356555 mirMAP -0.180264494036381 0.0053900883158062 NA NA NA hsa-miR-324-5p SOCS2 -0.50063248413014 0.537416710557032 0.103547594378292 0.888418334356555 miRanda -0.233019052480559 0.00080969904801171 NA NA NA hsa-miR-362-5p SOCS2 -0.26647467080141 0.752024885130738 0.103547594378292 0.888418334356555 TargetScan -0.142312730779582 0.00547393472692282 NA NA NA hsa-miR-421 SOCS2 -0.182032017078616 0.734704500318599 0.103547594378292 0.888418334356555 miRanda -0.178391355245339 0.00493271644002215 NA NA NA hsa-miR-429 SOCS2 -0.456485631615963 0.806240953400535 0.103547594378292 0.888418334356555 miRNATAP -0.153694365524066 0.00332387151644951 NA NA NA hsa-miR-501-5p SOCS2 -0.834032628506285 0.0582725160418523 0.103547594378292 0.888418334356555 mirMAP -0.139926349381956 0.00448631471160273 NA NA NA hsa-miR-7-5p SOCS2 0.209645143210379 0.773705612298441 0.103547594378292 0.888418334356555 miRNAWalker2_validate;miRNATAP -0.112431389571539 0.0066922245463907 NA NA NA hsa-miR-940 SOCS2 -0.225788347550697 0.680055767105815 0.103547594378292 0.888418334356555 miRNATAP -0.203549392743054 1.37673104556153e-05 NA NA NA hsa-miR-130b-5p SOCS3 -0.6472141103776 0.379096015222509 0.372533701183355 0.781110062301999 mirMAP -0.292111086420141 8.50659465916516e-05 NA NA NA hsa-miR-30c-5p SOCS3 -0.298383882401475 0.865809030482001 0.372533701183355 0.781110062301999 miRNAWalker2_validate -0.407119435891745 0.000169107018429663 26707189 Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR 30c in breast cancer; Our results further showed that the level of SOCS3 expression was induced by isolinderalactone due to inhibiting the microRNA hsa-miR-30c-5p miR-30c expression; In conclusion isolinderalactone induces apoptosis in MDA-MB‑231 cells and suppresses STAT3 signaling pathway through regulation of SOCS3 and miR-30c breast cancer hsa-miR-339-5p SOCS3 -0.300425087100667 0.712912847076788 0.372533701183355 0.781110062301999 miRanda -0.268179790417866 1.86778226117066e-05 NA NA NA hsa-let-7e-5p SOCS4 0.211156073215582 0.922335699862928 -0.0127919701041046 0.990487741126537 miRNATAP -0.131645777060058 0.00158489905945248 NA NA NA hsa-miR-125a-5p SOCS4 -0.00183986061615382 0.999158100170883 -0.0127919701041046 0.990487741126537 PITA;miRanda;miRNATAP -0.160117856068629 7.76775835793733e-06 NA NA NA hsa-miR-27a-3p SOCS4 -0.123902317731458 0.958804393510999 -0.0127919701041046 0.990487741126537 miRNATAP -0.160284443659787 0.000295146053936859 NA NA NA hsa-miR-34a-5p SOCS4 -0.50188164870224 0.742034237185732 -0.0127919701041046 0.990487741126537 miRNAWalker2_validate;miRNATAP -0.104396202545909 0.000419882319042362 NA NA NA hsa-miR-664a-3p SOCS4 -0.00395670341813714 0.996119749372707 -0.0127919701041046 0.990487741126537 mirMAP -0.103527118988607 0.00291906676855896 NA NA NA hsa-miR-126-5p SOCS5 0.0815213541035824 0.956637332055185 0.0945236250217372 0.92640325173441 mirMAP -0.134678865938075 2.35857416470307e-05 NA NA NA hsa-miR-16-5p SOCS5 0.0135949734723564 0.994476223855607 0.0945236250217372 0.92640325173441 miRNAWalker2_validate -0.136905162588925 7.84705493333291e-07 NA NA NA hsa-miR-590-3p SOCS5 -0.279244755376859 0.59126669933662 0.0945236250217372 0.92640325173441 miRanda;mirMAP -0.116226898035017 1.07951690971113e-08 NA NA NA hsa-miR-590-5p SOCS5 -0.547819833829572 0.472735645776647 0.0945236250217372 0.92640325173441 miRanda -0.130398419491679 1.08227897800427e-09 NA NA NA hsa-miR-96-5p SOCS7 0.0854810872029343 0.923087820185031 -0.00919272882729172 0.983897479830049 TargetScan -0.122531338804271 0.00602587664172314 NA NA NA hsa-miR-27a-3p SOS1 -0.123902317731458 0.958804393510999 -0.133663949462885 0.918709253182528 MirTarget;miRNATAP -0.128294784600539 0.000637917145382412 NA NA NA hsa-miR-369-3p SOS1 0.116576891957687 0.83230082995912 -0.133663949462885 0.918709253182528 miRNATAP -0.135959090885724 6.65395075102377e-09 NA NA NA hsa-miR-381-3p SOS1 0.0562600264188893 0.966895219811624 -0.133663949462885 0.918709253182528 MirTarget -0.100940916746464 0.00276528516676685 NA NA NA hsa-miR-130a-3p SOS2 0.0910074087716906 0.929098200371948 -0.0380982568268919 0.974772477648122 miRNATAP -0.106710417537474 0.00163707990890625 NA NA NA hsa-miR-146b-5p SOS2 -0.402662509440887 0.837510937985091 -0.0380982568268919 0.974772477648122 miRanda -0.166193413119417 6.48354241761314e-06 NA NA NA hsa-miR-154-5p SOS2 -0.058936877201993 0.864854818862396 -0.0380982568268919 0.974772477648122 miRNATAP -0.116649989146456 0.00011300613484555 NA NA NA hsa-miR-493-5p SOS2 0.229930075372342 0.731979520100109 -0.0380982568268919 0.974772477648122 miRNATAP -0.128957133953108 0.00138950642379943 NA NA NA hsa-miR-101-3p SPRED1 0.0107754887734437 0.997036362636866 -0.138587554374094 0.918142212148514 miRNATAP -0.193395909486898 0.0043069375588032 NA NA NA hsa-miR-106a-5p SPRED1 -0.203919267842652 0.802213958426804 -0.138587554374094 0.918142212148514 miRNATAP -0.124188288731001 0.00570883885912346 NA NA NA hsa-miR-130a-3p SPRED1 0.0910074087716906 0.929098200371948 -0.138587554374094 0.918142212148514 miRNATAP -0.183107684379278 8.00792542994518e-05 NA NA NA hsa-miR-188-5p SPRED1 -0.568517670542551 0.324820848307954 -0.138587554374094 0.918142212148514 PITA;miRNATAP -0.116134598357914 0.000489555574904072 NA NA NA hsa-miR-224-5p SPRED1 -0.240425158977724 0.857351098476517 -0.138587554374094 0.918142212148514 mirMAP -0.131910182355987 6.00516637655061e-05 NA NA NA hsa-miR-424-5p SPRED1 0.247080963500746 0.870154571783568 -0.138587554374094 0.918142212148514 miRNATAP -0.11138198573584 0.00323254185502293 NA NA NA hsa-miR-146b-5p SPRED2 -0.402662509440887 0.837510937985091 -0.0472560373281672 0.971671454689186 miRanda -0.102703115899583 0.00121913349594674 NA NA NA hsa-miR-493-5p SPRED2 0.229930075372342 0.731979520100109 -0.0472560373281672 0.971671454689186 miRNATAP -0.122529300691405 0.000350263161307048 NA NA NA hsa-miR-21-5p SPRY1 -0.148920887107433 0.970240620972126 0.0387337942247381 0.973021922748001 miRNATAP -0.213862689054633 0.000313606840830259 24155920 Functional studies showed that miR-21 over-expression in GICs induced comparable cell differentiation features and targeted SPRY1 mRNA which encodes for a negative regulator of neural stem-cell differentiation differentiation glioblastoma hsa-miR-548o-3p SPRY1 -0.191447572716994 0.517725546183501 0.0387337942247381 0.973021922748001 mirMAP -0.106201323719644 0.000941387426023675 NA NA NA hsa-miR-590-5p SPRY1 -0.547819833829572 0.472735645776647 0.0387337942247381 0.973021922748001 PITA;miRanda;miRNATAP -0.10801976290156 0.000489114987170171 NA NA NA hsa-miR-146b-5p SPRY3 -0.402662509440887 0.837510937985091 0.0115161336421017 0.975093130129341 mirMAP -0.296866789978979 1.12981554086208e-06 NA NA NA hsa-miR-155-5p SPRY3 -0.407235807706004 0.828669616718496 0.0115161336421017 0.975093130129341 mirMAP -0.256025527902892 1.26618493247741e-06 NA NA NA hsa-miR-21-3p SPRY3 -0.395016549347053 0.87819982773565 0.0115161336421017 0.975093130129341 mirMAP -0.174144813748235 0.00736861712391471 NA NA NA hsa-miR-223-3p SPRY3 -0.449245565106316 0.80968342565561 0.0115161336421017 0.975093130129341 mirMAP -0.153200223151035 5.4364295300235e-05 NA NA NA hsa-miR-330-3p SPRY3 0.00298687748748416 0.994504006750491 0.0115161336421017 0.975093130129341 mirMAP;miRNATAP -0.154293981410462 0.00988138562162642 NA NA NA hsa-miR-330-5p SPRY3 -0.283418953659271 0.815687101334695 0.0115161336421017 0.975093130129341 miRNATAP -0.282279719787282 6.76155852350394e-05 NA NA NA hsa-miR-582-5p SPRY3 -0.399450205475138 0.581227478860085 0.0115161336421017 0.975093130129341 mirMAP;miRNATAP -0.174737388165151 0.00308360533261845 NA NA NA hsa-miR-497-5p SPRY4 -0.0120217191428731 0.989147225742026 0.243351749160674 0.854234192479599 miRNATAP -0.146527245377845 0.00300848346602474 NA NA NA hsa-miR-126-5p STAM2 0.0815213541035824 0.956637332055185 -0.0670900969404817 0.953536259228676 mirMAP -0.108679832218501 0.00204632496359929 NA NA NA hsa-miR-143-5p STAM2 0.10589969923845 0.933358732923556 -0.0670900969404817 0.953536259228676 MirTarget -0.138361490120302 3.50132006104218e-08 NA NA NA hsa-miR-30c-1-3p STAT1 -0.202466672579761 0.511485842123022 -0.319752228521727 0.859158273631998 MirTarget -0.13895586646419 0.00668211536015187 NA NA NA hsa-miR-361-5p STAT1 -0.138735309928775 0.941495130308343 -0.319752228521727 0.859158273631998 miRanda -0.272062153340587 0.00703285274548935 NA NA NA hsa-miR-421 STAT1 -0.182032017078616 0.734704500318599 -0.319752228521727 0.859158273631998 miRanda;mirMAP -0.162957938001321 0.00424539044257476 NA NA NA hsa-miR-532-3p STAT1 -0.496590111092324 0.682889021782543 -0.319752228521727 0.859158273631998 MirTarget -0.184419063592768 0.000550521567590996 NA NA NA hsa-miR-96-5p STAT1 0.0854810872029343 0.923087820185031 -0.319752228521727 0.859158273631998 mirMAP -0.132555564768792 0.00950788034384437 NA NA NA hsa-miR-24-3p STAT2 -0.0484778924256624 0.985274054814493 -0.103744732365088 0.940181827449499 MirTarget -0.232412748831462 0.00915134265854298 NA NA NA hsa-miR-335-5p STAT2 -0.0284895175847679 0.973380867832231 -0.103744732365088 0.940181827449499 miRNAWalker2_validate -0.262989149822116 1.29142169016596e-11 NA NA NA hsa-miR-339-5p STAT2 -0.300425087100667 0.712912847076788 -0.103744732365088 0.940181827449499 miRanda -0.172950965516837 1.20508511804622e-06 NA NA NA hsa-miR-98-5p STAT2 -0.168162186023221 0.898802461503524 -0.103744732365088 0.940181827449499 MirTarget -0.208227938372428 0.000490047084649831 NA NA NA hsa-miR-106b-5p STAT3 -0.297128724729339 0.869294443540749 -0.171064990565998 0.92340354732603 miRNATAP -0.137066627615977 5.29214986392166e-05 27325313 We also found that EMMPRIN could down-regulate miR-106a and miR-106b expression in breast cancer cells which led to activating STAT3 and enhancing HIF-1α expression breast cancer hsa-miR-17-5p STAT3 -0.175448849583061 0.934544015912731 -0.171064990565998 0.92340354732603 TargetScan;miRNATAP -0.130315016386079 3.4088222625333e-07 NA NA NA hsa-miR-20a-5p STAT3 -0.179153323927949 0.928118119139752 -0.171064990565998 0.92340354732603 miRNAWalker2_validate;miRNATAP -0.121136649538278 1.62632694701771e-06 NA NA NA hsa-miR-92a-3p STAT3 0.0278830870766349 0.993247426671713 -0.171064990565998 0.92340354732603 miRNAWalker2_validate -0.120058190281067 7.87924231948814e-05 23820254 STAT3 upregulates miR 92a to inhibit RECK expression and to promote invasiveness of lung cancer cells; We demonstrate that STAT3 upregulates miR-92a to repress RECK via post-transcriptional inhibition lung cancer hsa-miR-93-5p STAT3 -0.611073677204699 0.825297877093193 -0.171064990565998 0.92340354732603 miRNAWalker2_validate;miRNATAP -0.11600293778378 0.000310256041778332 NA NA NA hsa-miR-141-3p STAT4 -0.31994058840327 0.87774106909065 -0.524795411551488 0.146148668264603 MirTarget;TargetScan -0.335169113810867 1.4081230929103e-05 24732377 Down regulation of miR 141 induced by helicobacter pylori promotes the invasion of gastric cancer by targeting STAT4; A luciferase assay revealed that miR-141 was directly bound to the 3'-untranslated regions 3'-UTR of STAT4; Over-expression of STAT4 was used to mimic miR-141 action in the invasion of gastric cancer; MiR-141 may play a pivotal role in controlling gastric cancer invasion through regulating STAT4 and maybe a potential target to treat gastric cancer gastric cancer hsa-miR-200a-3p STAT4 -0.367034437440907 0.851059894150266 -0.524795411551488 0.146148668264603 MirTarget -0.26565879469745 0.000450409164225596 NA NA NA hsa-miR-29b-1-5p STAT4 -0.642348119412534 0.293891497238796 -0.524795411551488 0.146148668264603 MirTarget -0.177380473133875 0.00685063662809747 NA NA NA hsa-miR-421 STAT4 -0.182032017078616 0.734704500318599 -0.524795411551488 0.146148668264603 miRanda -0.31172113898975 0.000377477475219255 NA NA NA hsa-miR-141-5p STAT5A -0.354590233549885 0.867642456336402 -0.0859742880305827 0.944204961553851 MirTarget -0.105853422787838 0.00449471948946019 25241899 Progesterone downregulation of miR 141 contributes to expansion of stem like breast cancer cells through maintenance of progesterone receptor and Stat5a; miR-141 directly targeted both PR and signal transducer and activator of transcription 5A Stat5a transcription factors important for MaSC expansion; These data support a mechanism by which P4-triggered loss of miR-141 facilitates breast cancer cell de-differentiation through deregulation of PR and Stat5a two transcription factors important for controlling mammary cell fate differentiation breast cancer hsa-miR-421 STAT5A -0.182032017078616 0.734704500318599 -0.0859742880305827 0.944204961553851 miRanda -0.15716363439173 5.39487931133104e-05 NA NA NA hsa-miR-141-3p STAT5B -0.31994058840327 0.87774106909065 0.187141530973207 0.8961115539604 MirTarget;TargetScan;miRNATAP -0.124139286164729 1.02760465809091e-07 NA NA NA hsa-miR-200a-3p STAT5B -0.367034437440907 0.851059894150266 0.187141530973207 0.8961115539604 MirTarget;miRNATAP -0.108016653633979 2.31955724937583e-06 NA NA NA hsa-miR-130b-5p TPO -0.6472141103776 0.379096015222509 -0.238196391773065 0.80147330105315 mirMAP -0.692306268928688 8.41165216255532e-07 NA NA NA hsa-miR-19a-3p TPO -0.206793507801887 0.844637784802316 -0.238196391773065 0.80147330105315 mirMAP -0.776393722515143 5.0007576661903e-11 NA NA NA hsa-miR-19b-3p TPO -0.0268530183621474 0.986656783046572 -0.238196391773065 0.80147330105315 mirMAP -1.03513098743277 1.16388196759279e-13 NA NA NA hsa-miR-25-3p TPO -0.457540448732733 0.878574066837636 -0.238196391773065 0.80147330105315 mirMAP -1.0984325545847 6.20566624130076e-08 NA NA NA hsa-miR-26b-5p TPO -0.0245931278499594 0.990377966314923 -0.238196391773065 0.80147330105315 miRNAWalker2_validate -0.907982289167593 3.03471596750783e-06 NA NA NA hsa-miR-29a-5p TPO -0.31835175571979 0.600442757817281 -0.238196391773065 0.80147330105315 mirMAP -0.835957720063514 1.25151474081943e-10 NA NA NA hsa-miR-30d-3p TPO -0.123474741320298 0.814905367625791 -0.238196391773065 0.80147330105315 mirMAP -0.747178928147256 4.06072336225634e-06 NA NA NA hsa-miR-32-5p TPO -0.05993267619119 0.952975951594959 -0.238196391773065 0.80147330105315 mirMAP -0.655024251326537 4.13479327540615e-06 NA NA NA hsa-miR-335-3p TPO -0.244830745789445 0.88450019116631 -0.238196391773065 0.80147330105315 mirMAP -1.06468438596403 2.25389207119001e-17 NA NA NA hsa-miR-335-5p TPO -0.0284895175847679 0.973380867832231 -0.238196391773065 0.80147330105315 miRNAWalker2_validate -0.857517751416598 4.29247191966848e-11 NA NA NA hsa-miR-33a-3p TPO -0.794543849238581 0.0105203072007922 -0.238196391773065 0.80147330105315 mirMAP -0.398453878387489 0.00140471571307528 NA NA NA hsa-miR-450b-5p TPO -0.0136687538973108 0.983149761399849 -0.238196391773065 0.80147330105315 mirMAP -0.650025776477709 1.94936006468725e-05 NA NA NA hsa-miR-590-3p TPO -0.279244755376859 0.59126669933662 -0.238196391773065 0.80147330105315 miRanda -0.592464344363216 9.97957006670728e-07 NA NA NA hsa-miR-7-1-3p TPO -0.462485777435991 0.665899751398166 -0.238196391773065 0.80147330105315 mirMAP -0.501883663638024 0.000482926642347258 NA NA NA hsa-miR-92a-3p TPO 0.0278830870766349 0.993247426671713 -0.238196391773065 0.80147330105315 mirMAP -1.13759260625648 1.75812350896091e-15 NA NA NA hsa-miR-29a-5p TSLP -0.31835175571979 0.600442757817281 0.726704638299736 0.185704172998583 mirMAP -0.412503003954129 9.74797598801763e-06 NA NA NA hsa-miR-33a-3p TSLP -0.794543849238581 0.0105203072007922 0.726704638299736 0.185704172998583 mirMAP -0.229004005961888 0.00904260964492292 NA NA NA hsa-miR-577 TSLP -1.06238199218774 0.326056761787754 0.726704638299736 0.185704172998583 PITA -0.187435976735773 0.000462985791903954 NA NA NA hsa-miR-590-3p TSLP -0.279244755376859 0.59126669933662 0.726704638299736 0.185704172998583 miRanda;mirMAP -0.278281474431729 0.00123407099590137 NA NA NA