miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-29b-3p ABL1 -0.228125979913806 0.0271621721891603 0.0367677644326827 0.557586764156183 miRNATAP -0.119422950033378 0.000331947917061817 NA NA NA hsa-miR-30a-5p ABL1 -0.778411951775343 2.73322451127932e-16 0.0367677644326827 0.557586764156183 miRNAWalker2_validate;MirTarget;miRNATAP -0.119780200950244 0.000523947512657604 23287430 In K562 leukemia cells overexpression of miR-30a reduced ABL1 and BCR-ABL1 protein expression decreased proliferation and arrested cell cycle progression between G1 and S; These findings strongly suggest that miR-30a acts as a tumor suppressor by downregulating ABL1 and BCR-ABL1 expression progression chronic myeloid leukemia hsa-miR-30e-5p ABL1 -0.0905907245198101 0.21196704484334 0.0367677644326827 0.557586764156183 MirTarget;miRNATAP -0.1387897119702 0.00390571974742246 NA NA NA hsa-miR-193a-3p ANAPC1 0.849206638484406 3.68101781083335e-14 -0.207254277632404 0.00854206408150208 miRanda -0.105249473758976 0.00492553813331979 NA NA NA hsa-miR-26b-5p ANAPC1 -0.251437253429904 0.00270935785098697 -0.207254277632404 0.00854206408150208 miRNAWalker2_validate -0.161745195907166 0.00190636325436732 NA NA NA hsa-miR-146b-5p ANAPC13 1.40714170253819 2.9559871816487e-12 -0.937280966571878 2.30258317583541e-36 miRanda -0.140006989802721 6.14137663664283e-11 NA NA NA hsa-miR-16-5p ANAPC13 0.934012514027655 4.85417898318515e-24 -0.937280966571878 2.30258317583541e-36 miRNAWalker2_validate -0.273293691917229 1.91557917934537e-09 NA NA NA hsa-miR-185-5p ANAPC13 1.05056378692621 1.31174187880682e-22 -0.937280966571878 2.30258317583541e-36 MirTarget -0.167272226551835 2.62227261583624e-05 NA NA NA hsa-miR-542-3p ANAPC13 0.431147917094433 0.000254981247606435 -0.937280966571878 2.30258317583541e-36 miRanda -0.139883777096705 0.000293500767636073 NA NA NA hsa-miR-30a-5p ANAPC5 -0.778411951775343 2.73322451127932e-16 0.111628310115037 0.00740970791020899 miRNAWalker2_validate -0.14350540201145 1.52995589364469e-10 NA NA NA hsa-miR-125a-3p ATM -0.372794471295036 0.000941729459601642 0.530797531772122 1.02844462108312e-10 miRanda -0.179965024380568 1.10498221966636e-05 NA NA NA hsa-miR-26b-5p ATM -0.251437253429904 0.00270935785098697 0.530797531772122 1.02844462108312e-10 MirTarget -0.185032803316412 0.000897517946339252 NA NA NA hsa-miR-29a-5p ATM -0.519003718107105 1.03351148282116e-06 0.530797531772122 1.02844462108312e-10 mirMAP -0.153905144304669 0.000365513905294653 NA NA NA hsa-miR-30b-5p ATM -1.18330589477119 6.8341618466966e-27 0.530797531772122 1.02844462108312e-10 mirMAP -0.228607322895133 2.14088060321202e-09 25202329 However specific miRNAs are downregulated in ATC such as those of the miR-200 and miR-30 families which are important negative regulators of cell migration invasion and epithelial-to-mesenchymal transition EMT processes that are overactivated in ATC cell migration thyroid cancer hsa-miR-324-5p ATM -0.487750893426456 3.74472736457965e-05 0.530797531772122 1.02844462108312e-10 miRanda -0.10710960945207 0.00612346545427813 NA NA NA hsa-miR-335-3p ATM -1.36498175550207 6.84287752180534e-13 0.530797531772122 1.02844462108312e-10 mirMAP -0.113210536832474 1.25366052986396e-06 NA NA NA hsa-miR-339-5p ATM 0.322848334531193 0.0117281778821612 0.530797531772122 1.02844462108312e-10 miRanda -0.101879382550005 0.00505045529852259 NA NA NA hsa-miR-362-3p ATM -0.753214251798232 3.0025661608035e-07 0.530797531772122 1.02844462108312e-10 miRanda -0.108774551175696 0.000687826877699034 NA NA NA hsa-miR-130a-3p ATR -0.667386596699886 1.34029167767774e-10 -0.193338657856393 0.0045262320583548 mirMAP -0.10408204913365 0.00317598583076379 NA NA NA hsa-miR-3613-5p ATR 1.6648190889407 3.78720979041391e-41 -0.193338657856393 0.0045262320583548 MirTarget -0.114162521773667 1.84179076340918e-05 NA NA NA hsa-miR-10b-3p BUB1 -0.8205021989966 7.84331443044781e-21 3.17104037290699 1.03937856004077e-46 MirTarget -1.65499976530732 3.66580832587514e-33 NA NA NA hsa-miR-139-5p BUB1 -0.704802495091118 2.36904108453776e-06 3.17104037290699 1.03937856004077e-46 miRanda -0.679693367227176 4.01552216623744e-14 NA NA NA hsa-miR-199a-5p BUB1 -1.64658415208633 1.01615659358973e-23 3.17104037290699 1.03937856004077e-46 miRanda -0.409698729853086 2.12031083414132e-07 NA NA NA hsa-miR-429 BUB1 -2.16569233119434 2.66862243626443e-37 3.17104037290699 1.03937856004077e-46 miRanda -0.716225807168407 1.79232714007534e-25 NA NA NA hsa-let-7b-5p CCNA1 0.770868211539597 6.63408323707647e-21 -1.35322101035816 4.94648859730581e-06 miRNAWalker2_validate -0.579583612679179 0.0024066854073803 NA NA NA hsa-miR-107 CCNA1 0.140046250553248 0.0943611632552367 -1.35322101035816 4.94648859730581e-06 miRanda -0.622097759592013 0.0018593375433491 NA NA NA hsa-miR-30d-5p CCNA1 -0.202727675788184 0.00659067084745794 -1.35322101035816 4.94648859730581e-06 MirTarget -0.580027338885722 0.0098902698526785 NA NA NA hsa-miR-30e-5p CCNA1 -0.0905907245198101 0.21196704484334 -1.35322101035816 4.94648859730581e-06 MirTarget -0.691887012301174 0.00287001284197145 NA NA NA hsa-miR-486-5p CCNA1 1.16748143760361 1.68410465883829e-08 -1.35322101035816 4.94648859730581e-06 miRanda -0.27880712153741 0.000350604442222083 NA NA NA hsa-miR-199a-5p CCNA2 -1.64658415208633 1.01615659358973e-23 2.57099802991202 1.43321811312028e-55 miRanda -0.328928706052916 4.17923127013932e-08 NA NA NA hsa-miR-199b-5p CCNA2 -2.39483476763681 1.04659509514884e-17 2.57099802991202 1.43321811312028e-55 miRanda -0.116390524408998 0.00179385124771832 NA NA NA hsa-miR-200b-3p CCNA2 -1.70383252137161 2.38979336321755e-30 2.57099802991202 1.43321811312028e-55 TargetScan -0.626116375899575 1.50106613329803e-24 NA NA NA hsa-miR-27b-3p CCNA2 -0.699527231242518 1.07356023759234e-15 2.57099802991202 1.43321811312028e-55 miRNATAP -0.992779991608095 1.29094677773566e-18 NA NA NA hsa-miR-29c-3p CCNA2 -0.238671318446745 0.0141475322347596 2.57099802991202 1.43321811312028e-55 MirTarget -0.361649866185823 0.0011118476415665 NA NA NA hsa-miR-429 CCNA2 -2.16569233119434 2.66862243626443e-37 2.57099802991202 1.43321811312028e-55 miRanda;miRNATAP -0.540354442716193 5.97858702852005e-25 NA NA NA hsa-miR-508-3p CCNA2 -3.41433288024917 3.47699261121175e-37 2.57099802991202 1.43321811312028e-55 MirTarget;PITA;miRNATAP -0.238250167372575 6.92652194746967e-12 NA NA NA hsa-miR-139-5p CCNB1 -0.704802495091118 2.36904108453776e-06 0.746056196261024 2.29738688823905e-11 miRanda -0.343792144462362 6.45221405723029e-18 NA NA NA hsa-let-7c-5p CCNB2 -0.293028324454433 0.00593011890352725 2.68902072262368 1.15691049020212e-47 miRNAWalker2_validate -0.52910065321013 1.71542040758595e-06 NA NA NA hsa-miR-23b-3p CCNB2 -0.533749586990474 2.46924776953771e-10 2.68902072262368 1.15691049020212e-47 miRNAWalker2_validate -0.93829379047333 2.74267875838544e-12 NA NA NA hsa-let-7e-5p CCND1 -0.727009689927955 1.30690859412163e-11 2.13480598480786 2.71111034411853e-47 miRTarBase;miRNATAP -0.309874613270473 0.000283950841354646 NA NA NA hsa-let-7g-5p CCND1 -0.739744008507763 1.07979566264383e-14 2.13480598480786 2.71111034411853e-47 miRNATAP -0.622969784922631 1.85126618527679e-11 NA NA NA hsa-miR-106a-5p CCND1 -0.830908656792615 2.67547872901508e-10 2.13480598480786 2.71111034411853e-47 MirTarget;miRNATAP -0.425464553504269 5.26102842088565e-10 NA NA NA hsa-miR-135a-5p CCND1 -2.13422485001223 6.29449029671498e-14 2.13480598480786 2.71111034411853e-47 mirMAP -0.135832732621826 2.9303290026017e-05 NA NA NA hsa-miR-183-5p CCND1 -1.21596931064487 1.31473205758898e-08 2.13480598480786 2.71111034411853e-47 miRNAWalker2_validate -0.374903452579708 3.93459169450664e-20 NA NA NA hsa-miR-193b-3p CCND1 -0.273325765316079 0.104328826585392 2.13480598480786 2.71111034411853e-47 miRNAWalker2_validate;miRTarBase;MirTarget -0.242980057535361 1.3298535415108e-05 27071318;20655737;20304954;21893020;26129688 MicroRNA 193b inhibits the proliferation migration and invasion of gastric cancer cells via targeting cyclin D1; Further mechanism study indicated that CCND1 was a direct target of miR-193b in GC;CCND1 and ETS1 were revealed to be regulated by miR-193b directly;MicroRNA 193b represses cell proliferation and regulates cyclin D1 in melanoma; Overexpression of miR-193b in Malme-3M cells down-regulated CCND1 mRNA and protein by > or = 50%; A luciferase reporter assay confirmed that miR-193b directly regulates CCND1 by binding to the 3'untranslated region of CCND1 mRNA; These studies indicate that miR-193b represses cell proliferation and regulates CCND1 expression and suggest that dysregulation of miR-193b may play an important role in melanoma development;In a previous study we reported that miR-193b represses cell proliferation and regulates cyclin D1 in melanoma cells suggesting that miR-193b could act as a tumor suppressor;Epigenetically altered miR 193b targets cyclin D1 in prostate cancer; It has been suggested that miR-193b targets cyclin D1 in several malignancies; Here our aim was to determine if miR-193b targets cyclin D1 in prostate cancer; Furthermore the PC cell lines 22Rv1 and VCaP which express low levels of miR-193b and high levels of CCND1 showed significant growth retardation when treated with a CDK4/6 inhibitor; In contrast the inhibitor had no effect on the growth of PC-3 and DU145 cells with high miR-193b and low CCND1 expression; Taken together our data demonstrate that miR-193b targets cyclin D1 in prostate cancer ;;;; gastric cancer;liver cancer;melanoma;melanoma;prostate cancer hsa-miR-20b-5p CCND1 -1.30218163823367 6.87172815978149e-17 2.13480598480786 2.71111034411853e-47 MirTarget;miRNATAP -0.398854407061578 1.06454795591623e-12 NA NA NA hsa-miR-214-5p CCND1 -1.44418790803397 1.50873538772684e-16 2.13480598480786 2.71111034411853e-47 MirTarget -0.347168835410485 4.02103564566879e-12 NA NA NA hsa-miR-29a-3p CCND1 -0.431613225927952 4.10166815070288e-08 2.13480598480786 2.71111034411853e-47 mirMAP -0.939711765610188 1.68520368520268e-16 NA NA NA hsa-miR-29b-3p CCND1 -0.228125979913806 0.0271621721891603 2.13480598480786 2.71111034411853e-47 mirMAP -0.387608162335363 2.20893060555751e-05 NA NA NA hsa-miR-495-3p CCND1 -0.742293735164333 7.11373308013543e-05 2.13480598480786 2.71111034411853e-47 MirTarget -0.181526805649212 0.000432098784713278 NA NA NA hsa-miR-9-5p CCND1 -2.23538606210968 1.28143998950751e-12 2.13480598480786 2.71111034411853e-47 miRNAWalker2_validate -0.163701601563252 7.92305196930194e-09 NA NA NA hsa-let-7e-5p CCND2 -0.727009689927955 1.30690859412163e-11 1.12254248674744 2.60370825886318e-19 miRNATAP -0.233612834039481 0.000392482925172286 NA NA NA hsa-let-7g-5p CCND2 -0.739744008507763 1.07979566264383e-14 1.12254248674744 2.60370825886318e-19 miRNATAP -0.192686043584521 0.0089075831083671 NA NA NA hsa-miR-106a-5p CCND2 -0.830908656792615 2.67547872901508e-10 1.12254248674744 2.60370825886318e-19 miRNATAP -0.225423059951479 2.69299129795332e-05 NA NA NA hsa-miR-10a-3p CCND2 -1.40380922426511 3.42207767326254e-23 1.12254248674744 2.60370825886318e-19 mirMAP -0.262198638789585 6.25176630952157e-08 NA NA NA hsa-miR-10b-3p CCND2 -0.8205021989966 7.84331443044781e-21 1.12254248674744 2.60370825886318e-19 mirMAP -0.448238682535571 6.77944940531982e-09 NA NA NA hsa-miR-135a-5p CCND2 -2.13422485001223 6.29449029671498e-14 1.12254248674744 2.60370825886318e-19 miRNATAP -0.131225655723756 1.33192381495194e-07 NA NA NA hsa-miR-141-3p CCND2 -5.87110686537457 1.20877726722907e-85 1.12254248674744 2.60370825886318e-19 MirTarget;TargetScan -0.139228651988037 1.29114997683213e-14 NA NA NA hsa-miR-188-5p CCND2 -1.74586655806628 1.50431624674552e-28 1.12254248674744 2.60370825886318e-19 PITA;mirMAP -0.254549789518694 2.9475657150123e-09 NA NA NA hsa-miR-200a-3p CCND2 -1.43409013664263 2.00188483717828e-20 1.12254248674744 2.60370825886318e-19 MirTarget -0.212833658265287 1.19682362163716e-06 NA NA NA hsa-miR-20b-5p CCND2 -1.30218163823367 6.87172815978149e-17 1.12254248674744 2.60370825886318e-19 miRNATAP -0.259528470369076 2.90568654364943e-09 NA NA NA hsa-miR-26a-1-3p CCND2 -1.56107117111696 6.75439319582901e-15 1.12254248674744 2.60370825886318e-19 mirMAP -0.123054440828334 0.000561186412955267 NA NA NA hsa-miR-29a-3p CCND2 -0.431613225927952 4.10166815070288e-08 1.12254248674744 2.60370825886318e-19 MirTarget;miRNATAP -0.257180845680541 0.00521051024582081 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-29a-5p CCND2 -0.519003718107105 1.03351148282116e-06 1.12254248674744 2.60370825886318e-19 mirMAP -0.175805947483669 0.00980240816278221 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-29c-3p CCND2 -0.238671318446745 0.0141475322347596 1.12254248674744 2.60370825886318e-19 MirTarget;miRNATAP -0.244609702834514 0.0011551466386057 NA NA NA hsa-miR-3065-3p CCND2 -1.64500070417457 9.57561660036697e-16 1.12254248674744 2.60370825886318e-19 MirTarget;miRNATAP -0.15735746874687 2.91648572740269e-06 NA NA NA hsa-miR-30a-3p CCND2 -0.955360819934585 1.97009535429185e-20 1.12254248674744 2.60370825886318e-19 mirMAP -0.322061265215125 1.10079970812633e-06 NA NA NA hsa-miR-30d-3p CCND2 -0.249777194282131 0.00235356711813496 1.12254248674744 2.60370825886318e-19 mirMAP -0.528583706650002 1.57965043070812e-09 NA NA NA hsa-miR-335-5p CCND2 -2.09515619961552 1.03765771499548e-25 1.12254248674744 2.60370825886318e-19 miRNAWalker2_validate -0.125391196936535 0.000218373131234068 NA NA NA hsa-miR-378a-3p CCND2 0.287244802401236 0.0501155019984562 1.12254248674744 2.60370825886318e-19 miRNAWalker2_validate -0.155216456838451 0.00181246322617494 NA NA NA hsa-miR-429 CCND2 -2.16569233119434 2.66862243626443e-37 1.12254248674744 2.60370825886318e-19 miRNATAP -0.226547302813025 1.44251591184469e-09 NA NA NA hsa-miR-500a-5p CCND2 -1.28374735824553 1.95870374809798e-20 1.12254248674744 2.60370825886318e-19 mirMAP -0.227276642384328 3.82424468920894e-06 NA NA NA hsa-miR-501-5p CCND2 -1.1103073934745 1.81589804886553e-16 1.12254248674744 2.60370825886318e-19 PITA;mirMAP;miRNATAP -0.210338351972789 4.15719063926169e-05 NA NA NA hsa-miR-577 CCND2 -1.48881999472397 7.03080165111147e-10 1.12254248674744 2.60370825886318e-19 PITA;mirMAP -0.106625188470732 0.000293795265070961 NA NA NA hsa-miR-660-5p CCND2 -1.20833564582661 8.48975910642834e-23 1.12254248674744 2.60370825886318e-19 mirMAP -0.376740011929223 2.58290869632093e-12 NA NA NA hsa-miR-362-3p CCND3 -0.753214251798232 3.0025661608035e-07 0.51821271483815 4.41964906922001e-09 miRanda -0.139754455099983 4.25864164139051e-05 NA NA NA hsa-miR-501-5p CCND3 -1.1103073934745 1.81589804886553e-16 0.51821271483815 4.41964906922001e-09 PITA -0.131433527243481 0.000178229069185252 NA NA NA hsa-miR-26a-5p CCNE1 -0.202091714279613 0.00166918288801054 0.816753258090501 1.03152776155512e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.415437722985115 0.000232432307489198 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen breast cancer hsa-miR-26b-5p CCNE1 -0.251437253429904 0.00270935785098697 0.816753258090501 1.03152776155512e-10 miRNAWalker2_validate;miRTarBase;miRNATAP -0.23088787472047 0.00736354340634514 NA NA NA hsa-miR-141-3p CCNE2 -5.87110686537457 1.20877726722907e-85 2.0856989067869 1.01741376720221e-50 TargetScan;miRNATAP -0.270473765628803 1.14631686095266e-39 NA NA NA hsa-miR-200a-3p CCNE2 -1.43409013664263 2.00188483717828e-20 2.0856989067869 1.01741376720221e-50 miRNAWalker2_validate;miRTarBase;miRNATAP -0.393696406224143 8.91288390936764e-14 22183793 Targetscan analysis suggested cyclin E2 as potential target of miR-200a b c; Luciferase reporter assay using vectors containing the 3'UTR of cyclin E2 showed that miR-200a b c could suppress luciferase activities; RT-PCR and immunoblotting studies revealed that overexpression of miR-200a b c reduced the mRNA and protein levels of cyclin E2 respectively lymphoma hsa-miR-200b-3p CCNE2 -1.70383252137161 2.38979336321755e-30 2.0856989067869 1.01741376720221e-50 miRNAWalker2_validate;miRTarBase -0.486981417898501 6.49815012075116e-21 NA NA NA hsa-miR-200c-3p CCNE2 -5.40303134829523 2.74173143360645e-94 2.0856989067869 1.01741376720221e-50 miRNAWalker2_validate;miRTarBase -0.294010001889963 1.26125378006145e-37 NA NA NA hsa-miR-26a-5p CCNE2 -0.202091714279613 0.00166918288801054 2.0856989067869 1.01741376720221e-50 miRNAWalker2_validate;miRTarBase;miRNATAP -0.532059064032621 0.000173741814281565 24116110;21901171 The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression poor survival;progression pancreatic cancer;acute myeloid leukemia hsa-miR-30a-5p CCNE2 -0.778411951775343 2.73322451127932e-16 2.0856989067869 1.01741376720221e-50 miRNATAP -0.723899209778526 7.38760000789901e-17 NA NA NA hsa-miR-30b-5p CCNE2 -1.18330589477119 6.8341618466966e-27 2.0856989067869 1.01741376720221e-50 miRNAWalker2_validate;miRTarBase -0.631291526113636 1.2680612848159e-18 22384020 A luciferase-based reporter assay demonstrated that miR-30b post-transcriptionally reduced 27% p = 0.005 of the gene expression by interacting with two binding sites in the 3'-UTR of CCNE2; The upregulation of miR-30b by trastuzumab may play a biological role in trastuzumab-induced cell growth inhibition by targeting CCNE2 breast cancer hsa-miR-30c-5p CCNE2 -1.08783070774238 2.02505402525786e-24 2.0856989067869 1.01741376720221e-50 miRNATAP -0.575864780888779 3.04753489838907e-14 NA NA NA hsa-miR-335-3p CCNE2 -1.36498175550207 6.84287752180534e-13 2.0856989067869 1.01741376720221e-50 mirMAP -0.152792321205036 0.00081907200415046 NA NA NA hsa-miR-429 CCNE2 -2.16569233119434 2.66862243626443e-37 2.0856989067869 1.01741376720221e-50 PITA;miRanda;miRNATAP -0.459044601341311 9.56581900492176e-26 NA NA NA hsa-miR-514a-3p CCNE2 -3.60916038800272 7.44698991540685e-35 2.0856989067869 1.01741376720221e-50 miRNATAP -0.19830492963348 9.59557758012475e-14 NA NA NA hsa-miR-532-3p CCNE2 -1.759223962964 7.9077916669414e-40 2.0856989067869 1.01741376720221e-50 PITA -0.590255637068497 1.15370880093858e-26 NA NA NA hsa-miR-577 CCNE2 -1.48881999472397 7.03080165111147e-10 2.0856989067869 1.01741376720221e-50 PITA;miRNATAP -0.177978903599561 7.85966733789834e-07 NA NA NA hsa-miR-146b-5p CDC14A 1.40714170253819 2.9559871816487e-12 -0.739615191188487 7.04718749848513e-12 miRanda -0.123783478679193 2.23366914894983e-05 NA NA NA hsa-miR-148a-3p CDC14A 0.343233211643815 0.00402279073598165 -0.739615191188487 7.04718749848513e-12 miRNATAP -0.143352497666391 0.00535723105549114 NA NA NA hsa-miR-148a-5p CDC14A 0.415500302855613 0.000691460831436767 -0.739615191188487 7.04718749848513e-12 mirMAP -0.205673853002135 3.4482549440339e-05 NA NA NA hsa-miR-186-5p CDC14A 0.507217561043443 9.04455748270995e-10 -0.739615191188487 7.04718749848513e-12 mirMAP -0.37947615781034 1.33781995654648e-07 NA NA NA hsa-miR-28-5p CDC14A 0.461962042257226 3.32424690573327e-11 -0.739615191188487 7.04718749848513e-12 PITA;miRanda -0.310186181802091 0.000340599910126311 NA NA NA hsa-miR-342-3p CDC14A 1.4124432570595 1.07208971556131e-28 -0.739615191188487 7.04718749848513e-12 miRanda -0.155154418524146 0.000444009019566819 NA NA NA hsa-miR-576-5p CDC14A 1.06681109513983 5.69294424466526e-24 -0.739615191188487 7.04718749848513e-12 mirMAP -0.251724646184214 2.76478563871803e-06 NA NA NA hsa-miR-590-3p CDC14A 1.13702599385212 3.53435739887793e-22 -0.739615191188487 7.04718749848513e-12 PITA;miRanda;mirMAP;miRNATAP -0.188013029459021 0.000120443039372932 NA NA NA hsa-miR-140-5p CDC14B 0.504309496243674 3.09884038729031e-11 -0.784077700913095 4.24267221076269e-19 miRanda -0.339731117027525 1.94061002485651e-07 NA NA NA hsa-miR-146b-3p CDC14B 1.20941495066078 2.12939149602665e-10 -0.784077700913095 4.24267221076269e-19 miRNATAP -0.186762286966161 1.2812312762389e-13 NA NA NA hsa-miR-148b-5p CDC14B 0.269550343699955 0.0383631776794927 -0.784077700913095 4.24267221076269e-19 mirMAP -0.131163412616109 0.00122578325227431 NA NA NA hsa-miR-15a-5p CDC14B 1.42663930007845 1.36006952074963e-57 -0.784077700913095 4.24267221076269e-19 miRNAWalker2_validate;MirTarget -0.336347858241995 5.46423663110995e-13 NA NA NA hsa-miR-15b-5p CDC14B 0.773001494057531 1.71784656078957e-16 -0.784077700913095 4.24267221076269e-19 MirTarget -0.345543778400584 1.08746865947176e-11 NA NA NA hsa-miR-16-5p CDC14B 0.934012514027655 4.85417898318515e-24 -0.784077700913095 4.24267221076269e-19 miRNAWalker2_validate;MirTarget -0.310188382532449 9.47915504134157e-10 NA NA NA hsa-miR-17-3p CDC14B 0.723795600017259 5.90151677164931e-18 -0.784077700913095 4.24267221076269e-19 MirTarget -0.320455507899372 2.40129436794845e-08 NA NA NA hsa-miR-185-5p CDC14B 1.05056378692621 1.31174187880682e-22 -0.784077700913095 4.24267221076269e-19 MirTarget -0.257072173059957 4.40544479697319e-09 NA NA NA hsa-miR-193a-5p CDC14B 1.29777740059595 2.16815694068336e-39 -0.784077700913095 4.24267221076269e-19 miRNATAP -0.398679451302487 4.42447186851031e-20 NA NA NA hsa-miR-195-5p CDC14B 0.346502644882604 0.0092562828415903 -0.784077700913095 4.24267221076269e-19 MirTarget -0.121791307754053 0.00150251982975834 NA NA NA hsa-miR-21-3p CDC14B 1.78837590049697 1.41655409877312e-33 -0.784077700913095 4.24267221076269e-19 mirMAP -0.287588438023163 5.33766733784561e-23 NA NA NA hsa-miR-27a-3p CDC14B 0.558934437526245 1.44256383086177e-12 -0.784077700913095 4.24267221076269e-19 miRNATAP -0.407980725964418 3.57837431625785e-11 NA NA NA hsa-miR-320a CDC14B 0.412740558379182 2.02929519701706e-05 -0.784077700913095 4.24267221076269e-19 mirMAP -0.222358166342988 2.06452639934987e-05 NA NA NA hsa-miR-320b CDC14B 0.300497419754843 0.0245219177384172 -0.784077700913095 4.24267221076269e-19 mirMAP -0.139918215359685 0.000247856961351207 NA NA NA hsa-miR-497-5p CDC14B 0.227757383708836 0.0600073987853074 -0.784077700913095 4.24267221076269e-19 MirTarget -0.1310330273081 0.00197757584377965 NA NA NA hsa-miR-542-3p CDC14B 0.431147917094433 0.000254981247606435 -0.784077700913095 4.24267221076269e-19 miRanda -0.142874314527777 0.000929780036951905 NA NA NA hsa-miR-576-5p CDC14B 1.06681109513983 5.69294424466526e-24 -0.784077700913095 4.24267221076269e-19 mirMAP -0.265319299490351 2.06976440243945e-09 NA NA NA hsa-miR-590-3p CDC14B 1.13702599385212 3.53435739887793e-22 -0.784077700913095 4.24267221076269e-19 miRanda;mirMAP -0.266582671270905 2.17274634206338e-11 NA NA NA hsa-miR-590-5p CDC14B 0.709763558412506 1.11883921359361e-11 -0.784077700913095 4.24267221076269e-19 miRanda -0.267433182055599 1.08342532587982e-08 NA NA NA hsa-miR-616-5p CDC14B 0.913426384742148 3.78418389333709e-09 -0.784077700913095 4.24267221076269e-19 mirMAP -0.150082820042461 3.81772512962355e-06 NA NA NA hsa-miR-188-5p CDC20 -1.74586655806628 1.50431624674552e-28 1.74436048940742 1.26349004261041e-25 miRNAWalker2_validate -0.303691649581765 2.4779187392077e-07 NA NA NA hsa-miR-23b-3p CDC20 -0.533749586990474 2.46924776953771e-10 1.74436048940742 1.26349004261041e-25 miRNAWalker2_validate -0.727336671900511 1.22591391122646e-10 NA NA NA hsa-miR-30a-5p CDC20 -0.778411951775343 2.73322451127932e-16 1.74436048940742 1.26349004261041e-25 miRNAWalker2_validate -0.991917565843653 1.08345420761549e-26 NA NA NA hsa-let-7b-5p CDC25A 0.770868211539597 6.63408323707647e-21 -0.689883089732843 3.93573723098268e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.42632369896694 1.07931765348062e-07 NA NA NA hsa-miR-15a-5p CDC25A 1.42663930007845 1.36006952074963e-57 -0.689883089732843 3.93573723098268e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.204681642541484 0.00207438279757802 NA NA NA hsa-miR-192-5p CDC25A 0.442478872410106 0.0669238175123954 -0.689883089732843 3.93573723098268e-08 miRNAWalker2_validate -0.132385127880884 4.68250783332466e-06 NA NA NA hsa-miR-195-5p CDC25A 0.346502644882604 0.0092562828415903 -0.689883089732843 3.93573723098268e-08 MirTarget;miRNATAP -0.226362761581254 1.68786507885736e-05 NA NA NA hsa-miR-21-5p CDC25A 2.51462371613332 3.30620591950316e-66 -0.689883089732843 3.93573723098268e-08 miRNAWalker2_validate;miRTarBase;miRNATAP -0.12858790003873 0.00104354276561792 19826040;20724916;21761201;21618027 microRNA 21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells; Unbiased microarray analysis combined with bioinformatics identified cell cycle regulator Cdc25A as a miR-21 target; miR-21 suppressed Cdc25A expression through a defined sequence in its 3'-untranslated region; We found that miR-21 is induced by serum starvation and DNA damage negatively regulates G1-S transition and participates in DNA damage-induced G2-M checkpoint through down-regulation of Cdc25A; Our data show a role of miR-21 in modulating cell cycle progression following stress providing a novel mechanism of Cdc25A regulation and a potential explanation of miR-21 in tumorigenesis;33' Diindolylmethane negatively regulates Cdc25A and induces a G2/M arrest by modulation of microRNA 21 in human breast cancer cells; Furthermore treatment of MCF-7 cells with DIM which increased microRNA 21 expression caused a downregulation of Cdc25A resulting in an inhibition of breast cancer cell proliferation;33' Diindolylmethane inhibits breast cancer cell growth via miR 21 mediated Cdc25A degradation; Furthermore treatment of MCF-7 cells with DIM increased miR-21 expression and down-regulated Cdc25A resulting in an inhibition of breast cancer cell proliferation;Further research demonstrated that the miR-21 inhibitor induced the upregulation of Cdc25A; Taken together these findings suggest that miR-21 inhibitor can increase IR-induced growth arrest and apoptosis in U251 glioblastoma cells at least in part by abrogating G2-M arrest and that Cdc25A is a potential target of miR-21 progression;tumorigenesis;;; colon cancer;breast cancer;breast cancer;glioblastoma hsa-miR-497-5p CDC25A 0.227757383708836 0.0600073987853074 -0.689883089732843 3.93573723098268e-08 MirTarget;miRNATAP -0.164796698386309 0.00486776998571564 NA NA NA hsa-miR-204-5p CDC25B -1.67490789640238 9.14741888352476e-10 0.69512214216171 4.96228149795194e-11 miRNATAP -0.141516835038019 8.81206120698199e-12 NA NA NA hsa-miR-27b-3p CDC25B -0.699527231242518 1.07356023759234e-15 0.69512214216171 4.96228149795194e-11 miRNATAP -0.411464600584344 2.04191764957766e-10 NA NA NA hsa-miR-429 CDC25B -2.16569233119434 2.66862243626443e-37 0.69512214216171 4.96228149795194e-11 miRanda -0.22133165644704 3.48889283387863e-13 NA NA NA hsa-miR-107 CDC27 0.140046250553248 0.0943611632552367 0.0935281860492188 0.073040402849042 miRanda;miRNATAP -0.100550538673538 0.00354480409196592 NA NA NA hsa-miR-199a-5p CDC6 -1.64658415208633 1.01615659358973e-23 2.61444727560539 1.05278662477334e-55 miRanda -0.341127835842701 2.11738903861672e-08 NA NA NA hsa-miR-199b-5p CDC6 -2.39483476763681 1.04659509514884e-17 2.61444727560539 1.05278662477334e-55 miRanda -0.121544911526184 0.00132518711704894 NA NA NA hsa-miR-26a-5p CDC6 -0.202091714279613 0.00166918288801054 2.61444727560539 1.05278662477334e-55 miRNAWalker2_validate -0.689304527868425 5.9212734018563e-05 25100863;27158389 Here it is demonstrated that miR26a and miR26b inhibit replication licensing and the proliferation migration and invasion of lung cancer cells by targeting CDC6; The current study suggests that miR26a miR26b and CDC6 and factors regulating their expression represent potential cancer diagnostic and prognostic markers as well as anticancer targets;miR 26a inhibits the proliferation of ovarian cancer cells via regulating CDC6 expression; Bioinformatics analysis revealed Cdc6 was a target gene of miR-26a; dual-luciferase assay and validation assay showed miR-26a could act on the 3'UTR of Cdc6 to regulate Cdc6 expression; These findings suggest that miR-26a may act on the 3'UTR of Cdc6 to regulate Cdc6 expression which then inhibit the proliferation of ovarian cancer cells and induce their apoptosis ; lung cancer;ovarian cancer hsa-miR-501-5p CDC6 -1.1103073934745 1.81589804886553e-16 2.61444727560539 1.05278662477334e-55 miRNAWalker2_validate -0.453920988105561 2.04817137303958e-09 NA NA NA hsa-miR-615-3p CDC6 -0.777370544471479 2.08193713560545e-08 2.61444727560539 1.05278662477334e-55 miRNAWalker2_validate -0.218647549854133 0.00466363042945244 NA NA NA hsa-miR-3065-3p CDC7 -1.64500070417457 9.57561660036697e-16 0.881770035731974 1.22834162784109e-15 MirTarget -0.126912731999123 1.55473201252822e-05 NA NA NA hsa-miR-3607-3p CDC7 -0.529788328085356 0.00511771034738625 0.881770035731974 1.22834162784109e-15 miRNATAP -0.126683559882094 0.00014144211033322 NA NA NA hsa-miR-429 CDC7 -2.16569233119434 2.66862243626443e-37 0.881770035731974 1.22834162784109e-15 miRanda -0.201872218629873 5.64188373141387e-10 NA NA NA hsa-miR-615-3p CDC7 -0.777370544471479 2.08193713560545e-08 0.881770035731974 1.22834162784109e-15 miRNAWalker2_validate -0.154964483000649 0.000543077864910344 NA NA NA hsa-miR-10b-3p CDK2 -0.8205021989966 7.84331443044781e-21 0.371509137108531 5.99773845629112e-11 mirMAP -0.170932324193587 5.80500988570859e-07 NA NA NA hsa-miR-10b-5p CDK2 -0.89971464210447 1.18190532299934e-20 0.371509137108531 5.99773845629112e-11 miRNAWalker2_validate -0.118692565754821 0.000146070422960447 NA NA NA hsa-miR-200b-3p CDK2 -1.70383252137161 2.38979336321755e-30 0.371509137108531 5.99773845629112e-11 TargetScan -0.12970122404519 1.01762720330858e-11 27496804 Correlating with the frequent loss of miR-200b in ESCC both CDK2 and PAF levels are significantly increased in ESCC tumors compared to case-matched normal tissues n = 119 both P < 0.0001 and correlate with markedly reduced survival P = 0.007 and P = 0.041 respectively poor survival esophageal cancer hsa-miR-23b-3p CDK2 -0.533749586990474 2.46924776953771e-10 0.371509137108531 5.99773845629112e-11 miRNAWalker2_validate -0.219368132932182 1.99509995795993e-09 NA NA NA hsa-miR-361-5p CDK2 0.0514169367202078 0.382929376393199 0.371509137108531 5.99773845629112e-11 miRNAWalker2_validate -0.193286996057625 0.000531264325186741 NA NA NA hsa-miR-429 CDK2 -2.16569233119434 2.66862243626443e-37 0.371509137108531 5.99773845629112e-11 miRanda;miRNATAP -0.129348459383424 9.83216432751438e-16 NA NA NA hsa-let-7a-3p CDK6 0.0677487960013088 0.460458477653989 -0.337517762588933 0.000683930986632226 miRNATAP -0.191952475229568 0.00152326159633293 NA NA NA hsa-miR-101-3p CDK6 0.683973909682285 2.88573524246948e-15 -0.337517762588933 0.000683930986632226 mirMAP -0.230464143338434 0.000161085212410487 NA NA NA hsa-miR-106b-5p CDK6 1.07509411417907 2.11739194181878e-36 -0.337517762588933 0.000683930986632226 mirMAP -0.160408664539701 0.00574724787212677 NA NA NA hsa-miR-107 CDK6 0.140046250553248 0.0943611632552367 -0.337517762588933 0.000683930986632226 miRNAWalker2_validate;miRTarBase;PITA;miRNATAP -0.199675588030875 0.00266957921136072 19407485;22491216;21264532;19688090 Enforced expression of miR-107 in MiaPACA-2 and PANC-1 cells downregulated in vitro growth and this was associated with repression of the putative miR-107 target cyclin-dependent kinase 6 thereby providing a functional basis for the epigenetic inactivation of this miRNA in pancreatic cancer;Levels of known miR-107 targets protein kinase Cε PKCε cyclin-dependent kinase 6 CDK6 and hypoxia-inducible factor 1-β HIF1-β decreased following NP/pre-miR-107 treatment;We have identified miR-107 as a potential regulator of CDK6 expression; A bioinformatics search revealed a putative target site for miR-107 within the CDK6 3' untranslated region; Expression of miR-107 in gastric cancer cell lines was found inversely correlated with CDK6 expression; miR-107 could significantly suppress CDK6 3' UTR luciferase reporter activity and this effect was not detectable when the putative 3' UTR target site was mutated; Consistent with the results of the reporter assay ectopic expression of miR-107 reduced both mRNA and protein expression levels of CDK6 inhibited proliferation induced G1 cell cycle arrest and blocked invasion of the gastric cancer cells; Our results suggest that miR-107 may have a tumor suppressor function by directly targeting CDK6 to inhibit the proliferation and invasion activities of gastric cancer cells;Using miRNA-target prediction analyses and the array data we listed up a set of likely targets of miR-107 and miR-185 for G1 cell cycle arrest and validate a subset of them using real-time RT-PCR and immunoblotting for CDK6 ;;; pancreatic cancer;head and neck cancer;gastric cancer;lung squamous cell cancer hsa-miR-148a-5p CDK6 0.415500302855613 0.000691460831436767 -0.337517762588933 0.000683930986632226 mirMAP -0.159259648718724 0.000364313889365372 NA NA NA hsa-miR-15a-5p CDK6 1.42663930007845 1.36006952074963e-57 -0.337517762588933 0.000683930986632226 miRNATAP -0.203915063579853 7.69806540214174e-05 NA NA NA hsa-miR-16-1-3p CDK6 1.51429140700091 3.17219833254498e-37 -0.337517762588933 0.000683930986632226 mirMAP -0.136395924905055 0.00114400622656354 NA NA NA hsa-miR-195-5p CDK6 0.346502644882604 0.0092562828415903 -0.337517762588933 0.000683930986632226 miRNAWalker2_validate;miRTarBase -0.186888455162125 5.00682650566728e-06 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively gastric cancer hsa-miR-29c-3p CDK6 -0.238671318446745 0.0141475322347596 -0.337517762588933 0.000683930986632226 miRNAWalker2_validate;miRTarBase;miRNATAP -0.205490672146365 0.000288499978675504 26396669 Furthermore through qPCR and Western blot assays confirmed that overexpression of miR-29c reduced CDK6 mRNA and protein levels; miR-29c could inhibit the proliferation migration and invasion of bladder cancer cells via regulating CDK6 bladder cancer hsa-miR-3613-5p CDK6 1.6648190889407 3.78720979041391e-41 -0.337517762588933 0.000683930986632226 miRNATAP -0.143151845849858 0.000265548659050746 NA NA NA hsa-miR-374a-3p CDK6 1.13863935833993 2.79089304015401e-44 -0.337517762588933 0.000683930986632226 mirMAP -0.215475812324155 0.000261280963064821 NA NA NA hsa-miR-374b-5p CDK6 0.0804104684417872 0.365593963035077 -0.337517762588933 0.000683930986632226 mirMAP -0.255765470017787 3.9713823905864e-05 NA NA NA hsa-miR-378a-3p CDK6 0.287244802401236 0.0501155019984562 -0.337517762588933 0.000683930986632226 mirMAP -0.101261595573785 0.00710290616527283 23333942 Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively gastric cancer hsa-miR-497-5p CDK6 0.227757383708836 0.0600073987853074 -0.337517762588933 0.000683930986632226 miRNATAP -0.146760711868953 0.00127145490092567 NA NA NA hsa-miR-139-5p CDK7 -0.704802495091118 2.36904108453776e-06 0.507631106228948 3.83101219385912e-14 miRanda -0.161184523738716 6.8071301605633e-11 NA NA NA hsa-miR-199a-3p CDK7 -1.61607426368083 1.97964980193147e-26 0.507631106228948 3.83101219385912e-14 MirTarget;miRNATAP -0.119885627797837 1.79252566688108e-07 NA NA NA hsa-miR-199a-5p CDK7 -1.64658415208633 1.01615659358973e-23 0.507631106228948 3.83101219385912e-14 miRanda -0.14462697434575 7.8343780257833e-12 NA NA NA hsa-miR-199b-3p CDK7 -1.61804389801139 1.97668652730486e-26 0.507631106228948 3.83101219385912e-14 MirTarget -0.119440917825679 1.92891084402186e-07 NA NA NA hsa-miR-106a-5p CDKN1A -0.830908656792615 2.67547872901508e-10 0.933852663827849 4.55444675105513e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.218600628700736 2.88939391057469e-05 25510666 After prediction with online software we further used dual-luciferase reporter gene assay to ensure that TP53INP1 and CDKN1A might be the direct targets of miR-106a liver cancer hsa-miR-10b-5p CDKN1A -0.89971464210447 1.18190532299934e-20 0.933852663827849 4.55444675105513e-14 miRNAWalker2_validate;miRTarBase -0.297067989678752 1.67500183935337e-05 NA NA NA hsa-miR-125a-5p CDKN1A -0.561874059994802 7.3931856356891e-13 0.933852663827849 4.55444675105513e-14 miRNAWalker2_validate;miRTarBase -0.32978155373342 0.000181727625486425 NA NA NA hsa-miR-20b-5p CDKN1A -1.30218163823367 6.87172815978149e-17 0.933852663827849 4.55444675105513e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.137763480888379 0.00149273487605735 NA NA NA hsa-miR-30b-3p CDKN1A -1.64703050862226 1.89878531036464e-31 0.933852663827849 4.55444675105513e-14 MirTarget -0.262528533661573 5.81397764129021e-09 NA NA NA hsa-miR-335-5p CDKN1A -2.09515619961552 1.03765771499548e-25 0.933852663827849 4.55444675105513e-14 miRNAWalker2_validate -0.129015957169685 9.12565108889168e-05 NA NA NA hsa-miR-345-5p CDKN1A -0.953479075875024 8.95459389953487e-14 0.933852663827849 4.55444675105513e-14 miRNAWalker2_validate;miRTarBase;MirTarget -0.197411366375212 0.000212824701961514 NA NA NA hsa-miR-363-3p CDKN1A -1.93551166555337 4.45368477487614e-32 0.933852663827849 4.55444675105513e-14 miRNAWalker2_validate;miRTarBase -0.206355244698441 9.10387020600093e-08 NA NA NA hsa-miR-429 CDKN1A -2.16569233119434 2.66862243626443e-37 0.933852663827849 4.55444675105513e-14 miRNATAP -0.148103052504028 6.31944175096861e-05 NA NA NA hsa-miR-221-3p CDKN1B 0.337895669520713 0.0136448974691037 0.239879984710899 0.000337937760572074 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.169197893944767 1.33586254266414e-10 23637992;19953484;23939688;19126397;20146005;23967190;17569667;22992757;17721077;20461750 miR-221 knockdown not only blocked cell cycle progression induced cell apoptosis and inhibited cell proliferation in-vitro but it also inhibited in-vivo tumor growth by targeting p27kip1;Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;A Slug/miR-221 network has been suggested linking miR-221 activity with the downregulation of a Slug repressor leading to Slug/miR-221 upregulation and p27Kip1 downregulation; Interference with this process can be achieved using antisense miRNA antagomiR molecules targeting miR-221 inducing the downregulation of Slug and the upregulation of p27Kip1;Moreover a series of functional assays demonstrated that mir-221 could directly inhibit cKit p27Kip1 and possibly other pivotal proteins in melanoma;Matched HCC and adjacent non-cancerous samples were assayed for the expression of miR-221 and three G1/S transition inhibitors: p27Kip1 p21WAF1/Cip1and TGF-β1 by in situ hybridization and immunohistochemistry respectively; Real time qRT-PCR was used to investigate miR-221 and p27Kip1 transcripts in different clinical stages; In result miR-221 and TGF-β1 are frequently up-regulated in HCC while p27Kip1 and p21WAF1/Cip1 proteins are frequently down-regulated; In conclusion miR-221 is important in tumorigenesis of HCC possibly by specifically down-regulating p27Kip1 a cell-cycle inhibitor;Additionally the PDGF-dependent increase in cell proliferation appears to be mediated by inhibition of a specific target of miR-221 and down-regulation of p27Kip1;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;Peptide nucleic acids targeting miR 221 modulate p27Kip1 expression in breast cancer MDA MB 231 cells; Targeting miR-221 by PNA resulted in i lowering of the hybridization levels of miR-221 measured by RT-qPCR ii upregulation of p27Kip1 gene expression measured by RT-qPCR and western blot analysis;Antagonism of either microRNA 221 or 222 in glioblastoma cells also caused an increase in p27Kip1 levels and enhanced expression of the luciferase reporter gene fused to the p27Kip1 3'UTR;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression progression;;;;staging;tumorigenesis;;;;;poor survival breast cancer;glioblastoma;breast cancer;melanoma;liver cancer;pancreatic cancer;prostate cancer;breast cancer;glioblastoma;ovarian cancer hsa-miR-222-3p CDKN1B 0.214811008033524 0.0965295551752457 0.239879984710899 0.000337937760572074 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.162802081961889 7.56681536640924e-09 19953484;26912358;24895988;24137356;17569667;27282281;20461750 Based on bioinformatic analysis we found that the seed sequences of miR-221 and miR-222 coincide with each other and p27kip1 is a target for miRNA-221/222;Besides microvesicle marker characterization we evidenced that miR-222 exosomal expression mostly reflected its abundance in the cells of origin correctly paralleled by repression of its target genes such as p27Kip1 and induction of the PI3K/AKT pathway thus confirming its functional implication in cancer;MiR-222 plays an important role in the tumorigenesis of CC possibly by specifically down-regulating p27Kip1 and PTEN;miR 222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27kip1; miR-222 upregulation induced an enhancement of ovarian cancer cell proliferation potential possibly by downregulating its target P27Kip1; A bioinformatic analysis showed that the 3'-UTR of the P27Kip1 mRNA contained a highly-conserved putative miR-222 binding site; Luciferase reporter assays demonstrated that P27Kip1 was a direct target of miR-222; Consistently there was an inverse correlation between the P27Kip1 and miR-222 expression levels in the ovarian cancer cell lines and tissues;miR 221 and miR 222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1; In all cell lines tested we show an inverse relationship between the expression of miR-221 and miR-222 and the cell cycle inhibitor p27Kip1; Consistently miR-221 and miR-222 knock-down through antisense LNA oligonucleotides increases p27Kip1 in PC3 cells and strongly reduces their clonogenicity in vitro;miR 222 confers the resistance of breast cancer cells to Adriamycin through suppression of p27kip1 expression; Immunofluorescence showed that miR-222 altered the subcellular location of p27kip1 in nucleus; The results showed that downregulation of miR-222 in MCF-7/Adr increased sensitivity to Adr and Adr-induced apoptosis and arrested the cells in G1 phase accompanied by more expressions of p27kip1 especially in nucleus; Taken together the results found that miR-222 induced Adr-resistance at least in part via suppressing p27kip1 expression and altering its subcellular localization and miR-222 inhibitors could reverse Adr-resistance of breast cancer cells;MiR 221 and MiR 222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B CDKNIC and overall survival; miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; In contrast CDKN1B expression was not associated with miR-221 or miR-222 expression ;;tumorigenesis;;;drug resistance;poor survival glioblastoma;melanoma;cervical and endocervical cancer;ovarian cancer;prostate cancer;breast cancer;ovarian cancer hsa-miR-30e-3p CDKN1B -0.205602546270795 0.00132666419729688 0.239879984710899 0.000337937760572074 MirTarget -0.176307424226376 0.00265440694535281 NA NA NA hsa-miR-222-3p CDKN1C 0.214811008033524 0.0965295551752457 -1.62382011215233 2.8158743548092e-25 miRNAWalker2_validate;miRTarBase;miRNATAP -0.219997946578335 0.00232914313838813 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01 ovarian cancer hsa-miR-25-3p CDKN1C 1.12016166564779 3.79069348635778e-48 -1.62382011215233 2.8158743548092e-25 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.805144394438157 1.5316605981747e-15 NA NA NA hsa-miR-34a-5p CDKN1C 1.07544567720768 1.81510842038009e-20 -1.62382011215233 2.8158743548092e-25 miRNATAP -0.457727970369107 6.47105066833668e-10 NA NA NA hsa-miR-590-3p CDKN1C 1.13702599385212 3.53435739887793e-22 -1.62382011215233 2.8158743548092e-25 miRanda -0.475999232799883 5.55267188592253e-11 NA NA NA hsa-let-7g-5p CDKN2A -0.739744008507763 1.07979566264383e-14 5.87290203242225 2.14502501029629e-98 miRNAWalker2_validate;miRTarBase -1.25962471749777 7.64294188171978e-10 NA NA NA hsa-miR-10b-5p CDKN2A -0.89971464210447 1.18190532299934e-20 5.87290203242225 2.14502501029629e-98 miRNAWalker2_validate;miRTarBase -1.75671947271251 6.10853343914583e-20 NA NA NA hsa-miR-125a-5p CDKN2A -0.561874059994802 7.3931856356891e-13 5.87290203242225 2.14502501029629e-98 miRanda -2.06036289512691 7.32563160108414e-17 NA NA NA hsa-miR-125b-5p CDKN2A -0.825456421494266 2.13029877878434e-15 5.87290203242225 2.14502501029629e-98 miRNAWalker2_validate -1.1843038441459 2.55583846679525e-10 23585871 In this study we further extend our studies by showing that miR-125b represses the protein product of the ink4a/ARF locus p14ARF in two prostate cancer cell lines LNCaP wild type-p53 and 22Rv1 both wild type and mutant p53 as well as in the PC-346C prostate cancer xenograft model that lentivirally overexpressed miR-125b; Conversely treatment of prostate cancer cells with an inhibitor of miR-125b anti-miR-125b resulted in increased expression of p14ARF decreased level of Mdm2 and induction of apoptosis; In addition overexpression of miR-125b in p53-deficient PC3 cells induced down-regulation of p14ARF which leads to increased cell proliferation through a p53-independent manner prostate cancer hsa-miR-615-3p CDKN2A -0.777370544471479 2.08193713560545e-08 5.87290203242225 2.14502501029629e-98 miRNAWalker2_validate -0.62764855855038 1.64709983587783e-05 NA NA NA hsa-miR-107 CDKN2B 0.140046250553248 0.0943611632552367 2.04747576389105 2.78966478416461e-42 PITA -0.341606111728209 0.00280095564692391 NA NA NA hsa-miR-125a-5p CDKN2B -0.561874059994802 7.3931856356891e-13 2.04747576389105 2.78966478416461e-42 miRanda -0.325001871215519 0.0058771653082361 NA NA NA hsa-miR-217 CDKN2B -1.32414431829977 4.20138196453017e-06 2.04747576389105 2.78966478416461e-42 miRanda -0.206454336265827 6.45903689419475e-11 NA NA NA hsa-miR-335-3p CDKN2B -1.36498175550207 6.84287752180534e-13 2.04747576389105 2.78966478416461e-42 mirMAP -0.277657452347747 3.82440692686675e-09 NA NA NA hsa-miR-375 CDKN2B -1.46468479447701 9.20596529469647e-07 2.04747576389105 2.78966478416461e-42 miRNAWalker2_validate;miRNATAP -0.139062408655297 6.63971665585845e-06 NA NA NA hsa-miR-429 CDKN2B -2.16569233119434 2.66862243626443e-37 2.04747576389105 2.78966478416461e-42 miRanda -0.468007559482429 4.44000676142117e-24 NA NA NA hsa-miR-501-3p CDKN2B -1.30538668412879 3.52127864608017e-18 2.04747576389105 2.78966478416461e-42 PITA -0.423591157937551 2.43070119341333e-13 NA NA NA hsa-miR-501-5p CDKN2B -1.1103073934745 1.81589804886553e-16 2.04747576389105 2.78966478416461e-42 mirMAP -0.523709859920651 3.07056653527068e-16 NA NA NA hsa-miR-502-3p CDKN2B -1.10416310320528 1.55354569985732e-22 2.04747576389105 2.78966478416461e-42 PITA -0.619485997741539 1.44486587299862e-16 NA NA NA hsa-miR-182-5p CDKN2C -0.608710746044567 0.0025264935278104 1.54739120455957 7.41632470039797e-43 MirTarget -0.172617483316098 6.35035296802719e-07 NA NA NA hsa-miR-577 CDKN2C -1.48881999472397 7.03080165111147e-10 1.54739120455957 7.41632470039797e-43 MirTarget;PITA;miRNATAP -0.182618631991029 7.70934583581678e-11 NA NA NA hsa-miR-139-5p CHEK1 -0.704802495091118 2.36904108453776e-06 0.456319318073493 7.67714564236562e-08 miRanda -0.201334410850163 4.99995152388081e-11 NA NA NA hsa-miR-429 CHEK1 -2.16569233119434 2.66862243626443e-37 0.456319318073493 7.67714564236562e-08 miRanda -0.163305925956301 1.73019935416689e-11 NA NA NA hsa-miR-501-5p CHEK1 -1.1103073934745 1.81589804886553e-16 0.456319318073493 7.67714564236562e-08 miRNATAP -0.126085075082127 0.000172043022269551 NA NA NA hsa-miR-27b-3p CUL1 -0.699527231242518 1.07356023759234e-15 0.298957922803077 4.90293521921766e-13 miRNAWalker2_validate -0.188711638059524 3.40675052530908e-14 NA NA NA hsa-miR-10b-3p DBF4 -0.8205021989966 7.84331443044781e-21 0.807841127285333 8.27866719962326e-16 MirTarget -0.522499939632659 1.32143792942486e-18 NA NA NA hsa-miR-199a-5p DBF4 -1.64658415208633 1.01615659358973e-23 0.807841127285333 8.27866719962326e-16 miRanda -0.110380868804976 0.000751803543025416 NA NA NA hsa-miR-3065-3p DBF4 -1.64500070417457 9.57561660036697e-16 0.807841127285333 8.27866719962326e-16 MirTarget -0.15438871721815 5.25433385775505e-09 NA NA NA hsa-miR-30a-5p DBF4 -0.778411951775343 2.73322451127932e-16 0.807841127285333 8.27866719962326e-16 MirTarget -0.464819352055394 7.85029855475237e-17 NA NA NA hsa-miR-30b-5p DBF4 -1.18330589477119 6.8341618466966e-27 0.807841127285333 8.27866719962326e-16 MirTarget -0.202321604568137 2.6817378391952e-05 NA NA NA hsa-miR-30c-5p DBF4 -1.08783070774238 2.02505402525786e-24 0.807841127285333 8.27866719962326e-16 MirTarget -0.315256541474164 1.66186602737815e-10 NA NA NA hsa-miR-30d-5p DBF4 -0.202727675788184 0.00659067084745794 0.807841127285333 8.27866719962326e-16 MirTarget -0.212688497867452 0.00675765364150614 NA NA NA hsa-miR-106a-5p E2F1 -0.830908656792615 2.67547872901508e-10 2.53036227911003 2.91997411351128e-60 miRNAWalker2_validate;miRTarBase;miRNATAP -0.275992147047679 0.000283117932352032 18521848 Inverse correlations were found between miR-17-5p and miR-106a levels and their target expression E2F1 P = 0.04 and P = 0.03 respectively; Inverse correlation between miR-17-5p and miR-106a and E2F1 levels supports E2F1 as a target mRNA for the two miRNAs colon cancer hsa-miR-10a-5p E2F1 -1.17164272592931 4.86621098042279e-24 2.53036227911003 2.91997411351128e-60 miRNAWalker2_validate -0.638614582879132 8.58908028243193e-16 NA NA NA hsa-miR-203a-3p E2F1 -2.25533513338731 1.77332845294014e-21 2.53036227911003 2.91997411351128e-60 miRTarBase -0.242780254411105 1.02470844432397e-09 25216463 miR 203 is a direct transcriptional target of E2F1 and causes G1 arrest in esophageal cancer cells; Here we reveal that miR-203 is regulated by E2F1 an important transcription factor that can induce cell proliferation by controlling cell cycle progression; We found that miR-203 expression was induced by cisplatin which also induced E2F1 protein accumulation in esophageal squamous cell carcinoma ESCC cell lines; miR-203 expression was elevated upon activation of ectopic E2F1 whereas this induction was abolished when the E2F1 gene was silenced; Moreover with luciferase reporter assays and chromatin immunoprecipitation ChIP assays we demonstrated that E2F1 transactivates miR-203 by directly binding to the miR-203 gene promoter; Taken together our data show that cancer-related miR-203 is a novel transcriptional target of E2F1 and that it regulates cell cycle arrest by participating in a feedback loop with E2F1 progression esophageal cancer hsa-miR-20b-5p E2F1 -1.30218163823367 6.87172815978149e-17 2.53036227911003 2.91997411351128e-60 miRNATAP -0.349547479314763 1.57763341395608e-08 NA NA NA hsa-miR-23b-3p E2F1 -0.533749586990474 2.46924776953771e-10 2.53036227911003 2.91997411351128e-60 miRNAWalker2_validate -0.780614728402968 2.21203802078218e-11 NA NA NA hsa-miR-362-3p E2F1 -0.753214251798232 3.0025661608035e-07 2.53036227911003 2.91997411351128e-60 miRNAWalker2_validate;miRanda;miRNATAP -0.249452542446504 0.000433611076721111 NA NA NA hsa-miR-429 E2F1 -2.16569233119434 2.66862243626443e-37 2.53036227911003 2.91997411351128e-60 miRNATAP -0.488234970057577 5.48455190607861e-22 NA NA NA hsa-let-7c-5p E2F2 -0.293028324454433 0.00593011890352725 2.99171336446398 2.23798131844129e-59 MirTarget -0.371963039884871 0.00121417083329914 NA NA NA hsa-let-7e-5p E2F2 -0.727009689927955 1.30690859412163e-11 2.99171336446398 2.23798131844129e-59 MirTarget -0.758943800834945 1.58935459222987e-12 NA NA NA hsa-let-7g-5p E2F2 -0.739744008507763 1.07979566264383e-14 2.99171336446398 2.23798131844129e-59 MirTarget -0.589922976190225 1.32033361911641e-06 NA NA NA hsa-miR-125a-5p E2F2 -0.561874059994802 7.3931856356891e-13 2.99171336446398 2.23798131844129e-59 MirTarget -1.16466053207424 1.63310548600442e-15 NA NA NA hsa-miR-125b-5p E2F2 -0.825456421494266 2.13029877878434e-15 2.99171336446398 2.23798131844129e-59 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.624542273070257 1.86557775055462e-08 22999819 miR 125b regulates the proliferation of glioblastoma stem cells by targeting E2F2; This study demonstrated that miR-125b plays important roles in regulating the proliferation of GSCs by directly targeting E2F2 glioblastoma hsa-miR-130a-3p E2F2 -0.667386596699886 1.34029167767774e-10 2.99171336446398 2.23798131844129e-59 miRNATAP -0.35525042512385 0.00199854703943748 NA NA NA hsa-miR-204-5p E2F2 -1.67490789640238 9.14741888352476e-10 2.99171336446398 2.23798131844129e-59 mirMAP -0.198399511221084 4.12578721985713e-06 NA NA NA hsa-miR-20b-5p E2F2 -1.30218163823367 6.87172815978149e-17 2.99171336446398 2.23798131844129e-59 MirTarget;miRNATAP -0.351425209967348 2.05305845038518e-06 NA NA NA hsa-miR-214-5p E2F2 -1.44418790803397 1.50873538772684e-16 2.99171336446398 2.23798131844129e-59 MirTarget;miRNATAP -0.302327754304377 4.78486413302768e-06 NA NA NA hsa-miR-26a-5p E2F2 -0.202091714279613 0.00166918288801054 2.99171336446398 2.23798131844129e-59 miRNATAP -0.508657196790124 0.00859925029565011 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC gastric cancer hsa-miR-30c-2-3p E2F2 -1.28402709024345 6.77577627955178e-25 2.99171336446398 2.23798131844129e-59 MirTarget -0.947740689784645 5.64260048568408e-30 NA NA NA hsa-miR-429 E2F2 -2.16569233119434 2.66862243626443e-37 2.99171336446398 2.23798131844129e-59 miRNATAP -0.564600050073129 9.609626857415e-21 NA NA NA hsa-miR-10a-5p E2F3 -1.17164272592931 4.86621098042279e-24 0.33200114811281 9.89708016022088e-06 miRNATAP -0.209911474873589 1.57076067358426e-10 NA NA NA hsa-miR-10b-5p E2F3 -0.89971464210447 1.18190532299934e-20 0.33200114811281 9.89708016022088e-06 miRNATAP -0.275056027616904 4.36476935239139e-12 NA NA NA hsa-miR-125a-3p E2F3 -0.372794471295036 0.000941729459601642 0.33200114811281 9.89708016022088e-06 PITA;miRNATAP -0.111879958245248 0.00255529985584268 NA NA NA hsa-miR-125a-5p E2F3 -0.561874059994802 7.3931856356891e-13 0.33200114811281 9.89708016022088e-06 PITA;miRanda;miRNATAP -0.269993887281631 1.42626490957603e-07 NA NA NA hsa-miR-200a-3p E2F3 -1.43409013664263 2.00188483717828e-20 0.33200114811281 9.89708016022088e-06 miRNATAP -0.106764157347262 2.29410650218291e-05 NA NA NA hsa-miR-200b-3p E2F3 -1.70383252137161 2.38979336321755e-30 0.33200114811281 9.89708016022088e-06 miRNAWalker2_validate;miRTarBase;TargetScan -0.135073036934236 8.16813954448479e-08 22139708;24830600 MicroRNA 200b reverses chemoresistance of docetaxel resistant human lung adenocarcinoma cells by targeting E2F3; We also identified E2F3 as a novel target of miR-200b; Luciferase reporters containing the 3' untranslated region sequence of E2F3 messenger RNA were used to demonstrate that miR-200b could directly target E2F3; Small interfering RNA-mediated E2F3 knockdown revealed similar effects as that of ectopic miR-200b expression; Decreased miR-200b expression was also detected in tumor tissues sampled from lung adenocarcinoma patients treated with docetaxel-based chemotherapy and was proved to be correlated with high expression of E2F3 decreased sensitivity to docetaxel and poor prognosis; Our results suggest that down-regulation of miR-200b could lead to E2F3 overexpression and in turn contribute to chemoresistance of lung adenocarcinoma cells to docetaxel;Previously we have shown that restoration of microRNA miR-200b significantly reverses chemoresistance of human LAD cells by targeting E2F3; HDAC1/4 suppression-induced rescue of miR-200b contributed to downregulation of E2F3 survivin and Aurora-A and upregulation of cleaved-caspase-3 drug resistance;worse prognosis;drug resistance lung cancer;lung cancer hsa-miR-30a-5p E2F3 -0.778411951775343 2.73322451127932e-16 0.33200114811281 9.89708016022088e-06 miRNATAP -0.142844677442882 0.0006889631055412 NA NA NA hsa-miR-23b-3p E2F4 -0.533749586990474 2.46924776953771e-10 0.389194539947773 9.30019519609281e-14 miRNAWalker2_validate -0.175367315833389 2.90045125183616e-07 NA NA NA hsa-let-7b-5p E2F5 0.770868211539597 6.63408323707647e-21 -0.848213171250953 2.25320424709425e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.393474207920125 1.89408272938994e-09 NA NA NA hsa-let-7i-5p E2F5 0.911372377723717 7.11483853341932e-31 -0.848213171250953 2.25320424709425e-17 MirTarget;miRNATAP -0.246847919438631 0.000240326114158948 NA NA NA hsa-miR-106b-5p E2F5 1.07509411417907 2.11739194181878e-36 -0.848213171250953 2.25320424709425e-17 MirTarget;miRNATAP -0.311208269425882 2.44965009103978e-07 23803041 Overexpression of miR-106b shortened the G0/G1 phase and accelerated cell cycle progression while reducing p21 and E2F5 without any significant effects on the capacity for migration and invasion of gastric cancer cells; miR-106b may promote cell cycling of gastric cancer cells through regulation of p21 and E2F5 target gene expression progression gastric cancer hsa-miR-181a-5p E2F5 1.11111114875339 3.97880443756442e-29 -0.848213171250953 2.25320424709425e-17 MirTarget;miRNATAP -0.333996679242043 1.85929958292906e-10 24529171 Mechanism investigation revealed that miR-181a inhibited the expression of transcription factor E2F5 by specifically targeting its mRNA 3'UTR; Moreover E2F5 inhibition induced cell growth and rescued the suppressive effect of miR-181a inhibitor on the proliferation of SMMC-7721 cells; Those results strongly suggested that HBV down-regulated E2F5 expression in part by up-regulating the expression of miR-181a; Up-regulation of miR-181a by HBV in hepatoma cells may contribute to the progression of HCC possibly by targeting E2F5 suggesting miR-181a plays important role in HCC development progression liver cancer hsa-miR-181b-5p E2F5 1.49054296272357 3.69051660739368e-41 -0.848213171250953 2.25320424709425e-17 MirTarget;miRNATAP -0.306140971962342 8.10692003290236e-12 NA NA NA hsa-miR-181c-5p E2F5 0.762784646696248 4.48373118147729e-10 -0.848213171250953 2.25320424709425e-17 MirTarget;miRNATAP -0.247449274113639 5.58435057759617e-08 NA NA NA hsa-miR-181d-5p E2F5 1.00720380524132 6.04219503683814e-14 -0.848213171250953 2.25320424709425e-17 MirTarget -0.267607666591547 3.96134385812077e-11 NA NA NA hsa-miR-34a-5p E2F5 1.07544567720768 1.81510842038009e-20 -0.848213171250953 2.25320424709425e-17 miRNAWalker2_validate;MirTarget;miRNATAP -0.194672600839302 3.25502813362035e-05 26103003 MicroRNA 34a targets FMNL2 and E2F5 and suppresses the progression of colorectal cancer; FMNL2 and E2F5 were identified as direct targets of miR-34a; Reintroduction of FMNL2 or E2F5 without 3'UTR region reversed the inhibitory effects of miR-34a on cell proliferation and invasion; MiR-34a was down-regulated in CRC cells and inversely correlated with FMNL2 and E2F5 expressions; Our study suggests that miR-34a is an important tumor suppressor of CRC progression by targeting FMNL2 and E2F5 thus providing new insight into the molecular mechanisms underlying CRC progression and establishing a strong potential for the application of miR-34a as a novel therapeutic marker against CRC progression colorectal cancer hsa-miR-93-5p E2F5 1.37365940377595 2.37567548683245e-46 -0.848213171250953 2.25320424709425e-17 MirTarget;miRNATAP -0.225064762596954 1.52804433770536e-05 NA NA NA hsa-miR-106b-5p EP300 1.07509411417907 2.11739194181878e-36 -0.147148678710588 0.0405321000139646 miRNATAP -0.261995772265445 1.08364064661463e-10 NA NA NA hsa-miR-186-5p EP300 0.507217561043443 9.04455748270995e-10 -0.147148678710588 0.0405321000139646 miRNATAP -0.121597586405933 0.00972259491444961 NA NA NA hsa-miR-22-3p EP300 0.198460552200729 0.00761005672059428 -0.147148678710588 0.0405321000139646 MirTarget;miRNATAP -0.164572270687749 0.00217699129328605 NA NA NA hsa-miR-26b-5p EP300 -0.251437253429904 0.00270935785098697 -0.147148678710588 0.0405321000139646 miRNAWalker2_validate;miRNATAP -0.150155147849394 0.00151617840802469 NA NA NA hsa-miR-339-5p EP300 0.322848334531193 0.0117281778821612 -0.147148678710588 0.0405321000139646 miRanda -0.150136558180177 8.30541099155694e-07 NA NA NA hsa-miR-361-3p EP300 1.08992546227594 1.13197240706704e-36 -0.147148678710588 0.0405321000139646 PITA -0.124298281144442 0.00252789477423822 NA NA NA hsa-let-7a-5p ESPL1 0.0791334022258656 0.422980622613373 0.593810201467152 0.000519527388251548 MirTarget;TargetScan -0.279316871374092 0.00399344269188551 NA NA NA hsa-let-7c-5p ESPL1 -0.293028324454433 0.00593011890352725 0.593810201467152 0.000519527388251548 MirTarget -0.240063405043256 0.00727965304404598 NA NA NA hsa-let-7e-5p ESPL1 -0.727009689927955 1.30690859412163e-11 0.593810201467152 0.000519527388251548 MirTarget -0.445853317327314 1.44666430265915e-07 NA NA NA hsa-let-7f-5p ESPL1 -0.117703832394463 0.483893124265895 0.593810201467152 0.000519527388251548 MirTarget -0.180591444632215 0.00140195045037171 NA NA NA hsa-let-7g-5p ESPL1 -0.739744008507763 1.07979566264383e-14 0.593810201467152 0.000519527388251548 MirTarget -0.263543145443788 0.00595213002803408 NA NA NA hsa-miR-10a-5p ESPL1 -1.17164272592931 4.86621098042279e-24 0.593810201467152 0.000519527388251548 miRNAWalker2_validate -0.500898686148989 1.54555222110442e-11 NA NA NA hsa-miR-125a-5p ESPL1 -0.561874059994802 7.3931856356891e-13 0.593810201467152 0.000519527388251548 miRanda -0.418458519643707 0.000387495842491948 NA NA NA hsa-miR-149-5p ESPL1 -1.95790336710741 8.46371715052367e-27 0.593810201467152 0.000519527388251548 miRNAWalker2_validate -0.140552108725308 0.00334979039885095 NA NA NA hsa-miR-429 ESPL1 -2.16569233119434 2.66862243626443e-37 0.593810201467152 0.000519527388251548 miRanda -0.162418531923157 0.00108357379461205 NA NA NA hsa-miR-125a-5p FZR1 -0.561874059994802 7.3931856356891e-13 0.334171716838181 3.1510214665821e-06 mirMAP -0.155952633869521 0.00170577556940745 NA NA NA hsa-miR-532-3p FZR1 -1.759223962964 7.9077916669414e-40 0.334171716838181 3.1510214665821e-06 mirMAP -0.103487482347878 8.69232500591252e-05 NA NA NA hsa-miR-130b-3p GADD45A 1.12788913578446 2.939369462276e-16 -0.71804270155153 2.2880912615879e-10 MirTarget;miRNATAP -0.192802325941396 1.24534330083127e-05 NA NA NA hsa-miR-146b-5p GADD45A 1.40714170253819 2.9559871816487e-12 -0.71804270155153 2.2880912615879e-10 miRanda -0.121731151301817 6.74215575167157e-05 NA NA NA hsa-miR-301a-3p GADD45A 0.259400847075798 0.0216890736701418 -0.71804270155153 2.2880912615879e-10 MirTarget;miRNATAP -0.161714923757434 0.00452184693981742 NA NA NA hsa-miR-361-3p GADD45A 1.08992546227594 1.13197240706704e-36 -0.71804270155153 2.2880912615879e-10 MirTarget -0.218642571070405 0.00105969438528677 NA NA NA hsa-miR-454-3p GADD45A 0.68285296887698 1.17407812677787e-08 -0.71804270155153 2.2880912615879e-10 MirTarget;miRNATAP -0.236333328240283 5.72279489466588e-06 NA NA NA hsa-miR-590-3p GADD45A 1.13702599385212 3.53435739887793e-22 -0.71804270155153 2.2880912615879e-10 miRanda;mirMAP -0.217410143684049 1.97603197692947e-05 NA NA NA hsa-miR-140-5p GADD45B 0.504309496243674 3.09884038729031e-11 -0.441816165211003 0.00276475211524877 miRanda -0.283153773830058 0.00746764408150905 NA NA NA hsa-miR-1976 GADD45B 0.343475600930938 0.000360243844871748 -0.441816165211003 0.00276475211524877 miRNATAP -0.307872195722378 0.000272522224222968 NA NA NA hsa-miR-324-3p GADD45B -0.197662887871899 0.0298845059559819 -0.441816165211003 0.00276475211524877 MirTarget;miRNATAP -0.247089916093826 0.00645517764784922 NA NA NA hsa-miR-181a-5p GADD45G 1.11111114875339 3.97880443756442e-29 -0.695169717761439 6.17291350390005e-05 miRNAWalker2_validate -0.308928800063779 0.00053609177523059 NA NA NA hsa-miR-1976 GADD45G 0.343475600930938 0.000360243844871748 -0.695169717761439 6.17291350390005e-05 MirTarget -0.324215450846578 0.00121322985194693 NA NA NA hsa-miR-320a GADD45G 0.412740558379182 2.02929519701706e-05 -0.695169717761439 6.17291350390005e-05 miRanda -0.461886062957496 2.61555335659708e-06 NA NA NA hsa-miR-181a-5p GSK3B 1.11111114875339 3.97880443756442e-29 -0.228723498264944 0.000365732006378195 mirMAP -0.111663336693774 0.0006569391284283 NA NA NA hsa-miR-181b-5p GSK3B 1.49054296272357 3.69051660739368e-41 -0.228723498264944 0.000365732006378195 mirMAP -0.112111617296075 6.37240999540997e-05 NA NA NA hsa-miR-18a-5p GSK3B 0.936704393213466 1.05064580570579e-10 -0.228723498264944 0.000365732006378195 miRNATAP -0.129655229012053 2.96928927454631e-08 NA NA NA hsa-miR-19a-3p GSK3B 0.722913586880779 2.76301458932381e-10 -0.228723498264944 0.000365732006378195 mirMAP -0.128885925042799 1.75451278817822e-05 NA NA NA hsa-miR-19b-3p GSK3B 0.195940928879427 0.0300512922542325 -0.228723498264944 0.000365732006378195 mirMAP -0.147506705421778 0.000182148718420472 NA NA NA hsa-miR-26b-5p GSK3B -0.251437253429904 0.00270935785098697 -0.228723498264944 0.000365732006378195 miRNATAP -0.153051347819886 0.000309841684251065 NA NA NA hsa-miR-27a-3p GSK3B 0.558934437526245 1.44256383086177e-12 -0.228723498264944 0.000365732006378195 miRNATAP -0.194470247735897 7.8023921113285e-06 NA NA NA hsa-miR-590-3p GSK3B 1.13702599385212 3.53435739887793e-22 -0.228723498264944 0.000365732006378195 miRanda;miRNATAP -0.108155182029881 0.000128807781068845 NA NA NA hsa-miR-28-5p HDAC1 0.461962042257226 3.32424690573327e-11 -0.26069218953464 3.16500966280369e-06 miRanda -0.135368414899127 0.00206548950372119 NA NA NA hsa-miR-374a-3p HDAC2 1.13863935833993 2.79089304015401e-44 -0.296702961466692 7.03992845213639e-07 mirMAP -0.116893509074138 0.0010971503256489 NA NA NA hsa-miR-139-5p MAD2L1 -0.704802495091118 2.36904108453776e-06 0.840630479185054 5.57688776697025e-15 miRanda -0.260745282509813 5.92383202111684e-11 NA NA NA hsa-miR-362-3p MAD2L1 -0.753214251798232 3.0025661608035e-07 0.840630479185054 5.57688776697025e-15 miRanda -0.131964017036521 0.00200402288364129 NA NA NA hsa-miR-139-5p MCM2 -0.704802495091118 2.36904108453776e-06 0.556309367704881 3.01593305804015e-08 miRanda -0.201673009588276 3.81993111799754e-08 NA NA NA hsa-miR-500a-5p MCM2 -1.28374735824553 1.95870374809798e-20 0.556309367704881 3.01593305804015e-08 miRNAWalker2_validate -0.195583570274879 2.45053813863991e-07 NA NA NA hsa-miR-501-3p MCM2 -1.30538668412879 3.52127864608017e-18 0.556309367704881 3.01593305804015e-08 miRNAWalker2_validate -0.128553543262143 0.000302180242352355 NA NA NA hsa-miR-615-3p MCM2 -0.777370544471479 2.08193713560545e-08 0.556309367704881 3.01593305804015e-08 miRNAWalker2_validate -0.190225390504607 1.42836226310823e-06 NA NA NA hsa-let-7b-5p MCM4 0.770868211539597 6.63408323707647e-21 -0.463544749484371 2.53740544216115e-07 miRNAWalker2_validate -0.186545003497773 0.0013028631474607 NA NA NA hsa-miR-24-3p MCM4 0.173813044685099 0.00565259443420961 -0.463544749484371 2.53740544216115e-07 miRNAWalker2_validate -0.244007039205164 0.0028111853913591 NA NA NA hsa-miR-338-3p MCM4 0.906250377628867 2.76970900371139e-15 -0.463544749484371 2.53740544216115e-07 MirTarget;miRanda -0.135994262377628 0.00123489477359347 NA NA NA hsa-miR-362-3p MCM5 -0.753214251798232 3.0025661608035e-07 1.09580550180355 5.33293979907536e-37 miRanda -0.165603539019416 5.6378158610176e-06 NA NA NA hsa-miR-30c-2-3p MCM6 -1.28402709024345 6.77577627955178e-25 0.380487968863609 9.92773274365509e-09 MirTarget -0.259945896014888 1.13930506351765e-23 NA NA NA hsa-miR-429 MCM6 -2.16569233119434 2.66862243626443e-37 0.380487968863609 9.92773274365509e-09 miRanda -0.123050746345037 1.05381839344946e-10 NA NA NA hsa-miR-145-5p MDM2 -0.459160400949571 0.000776344261622237 0.793190906694193 8.44776116028465e-23 miRNAWalker2_validate -0.147065370036944 1.95227314117328e-05 NA NA NA hsa-miR-23b-3p MDM2 -0.533749586990474 2.46924776953771e-10 0.793190906694193 8.44776116028465e-23 mirMAP -0.315717493386307 6.44067502421801e-09 NA NA NA hsa-miR-26b-5p MDM2 -0.251437253429904 0.00270935785098697 0.793190906694193 8.44776116028465e-23 miRNAWalker2_validate -0.200227881151587 0.000439991070511547 NA NA NA hsa-miR-374b-5p MDM2 0.0804104684417872 0.365593963035077 0.793190906694193 8.44776116028465e-23 mirMAP -0.208884138903245 0.000106081838021418 NA NA NA hsa-miR-429 MDM2 -2.16569233119434 2.66862243626443e-37 0.793190906694193 8.44776116028465e-23 miRanda -0.140702422709165 9.18245159970993e-09 NA NA NA hsa-miR-500a-5p MDM2 -1.28374735824553 1.95870374809798e-20 0.793190906694193 8.44776116028465e-23 mirMAP -0.190652593253116 1.86314563864775e-09 NA NA NA hsa-let-7g-5p MYC -0.739744008507763 1.07979566264383e-14 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate;miRTarBase -0.398905767136213 2.71236287032834e-05 NA NA NA hsa-miR-135a-5p MYC -2.13422485001223 6.29449029671498e-14 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.108827259333515 0.000903589484065675 23176581 Moreover based on the results of this analysis we investigated whether miR-135a targeted the c-MYC gene in RCC; Gain-of-function and luciferase reporter assays showed that c-MYC was directly regulated by miR-135a in RCC cells kidney renal cell cancer hsa-miR-335-5p MYC -2.09515619961552 1.03765771499548e-25 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.216426299788151 7.62566723121896e-07 NA NA NA hsa-miR-429 MYC -2.16569233119434 2.66862243626443e-37 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.389721783902253 2.72292816859272e-16 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-744-5p MYC -0.348985243196771 0.000187889982228835 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.377458526504721 0.000190443255959769 24991193 Decrease expression of microRNA 744 promotes cell proliferation by targeting c Myc in human hepatocellular carcinoma; Quantitative reverse-transcription polymerase chain reaction qRT-PCR was conducted to detect the expression of miR-744 and Immunohistochemistry was performed to detect expression of c-Myc in HCC specimens and adjacent normal tissues; Luciferase reporter assays was performed to confirm whether miR-744 regulated the expression of c-Myc; Luciferase assay and Western blot analysis revealed that c-Myc is a direct target of miR-744; Down-regulation of miR-744 and up-regulation of c-Myc were detected in HCC specimens compared with adjacent normal tissues; Moreover restoration of miR-744 rescues c-Myc induced HCC proliferation; Our data suggest that miR-744 exerts its tumor suppressor function by targeting c-Myc leading to the inhibition of HCC cell growth liver cancer hsa-miR-30a-5p PCNA -0.778411951775343 2.73322451127932e-16 0.17116305078581 0.00459627045438189 miRNAWalker2_validate -0.168765320611941 3.4105963819675e-07 NA NA NA hsa-miR-338-5p PCNA 0.628429807914222 1.27575140717947e-06 0.17116305078581 0.00459627045438189 PITA -0.114211329907983 7.75574175325775e-06 NA NA NA hsa-miR-874-3p PLK1 -1.50243370621573 8.39418307315909e-25 2.66536332785907 3.79298943325418e-43 miRNAWalker2_validate -0.510928907899272 1.27896133323905e-11 NA NA NA hsa-miR-455-5p PRKDC 0.773674551205946 2.12957541541474e-09 -0.556206315716691 9.30697298557911e-11 miRanda -0.148751453426507 4.79909886042641e-05 NA NA NA hsa-miR-590-3p PRKDC 1.13702599385212 3.53435739887793e-22 -0.556206315716691 9.30697298557911e-11 mirMAP -0.116544570154834 0.00273902773664963 NA NA NA hsa-miR-26a-5p PTTG1 -0.202091714279613 0.00166918288801054 2.6328652623396 3.73178731264793e-46 miRNAWalker2_validate -0.501026731233899 0.0071410598039084 NA NA NA hsa-miR-181a-5p RAD21 1.11111114875339 3.97880443756442e-29 -0.443580185174969 9.51779143683762e-14 MirTarget;miRNATAP -0.152207252199382 9.89120328146127e-07 NA NA NA hsa-miR-181b-5p RAD21 1.49054296272357 3.69051660739368e-41 -0.443580185174969 9.51779143683762e-14 MirTarget;miRNATAP -0.15535923958795 4.46286997283385e-09 NA NA NA hsa-miR-181c-5p RAD21 0.762784646696248 4.48373118147729e-10 -0.443580185174969 9.51779143683762e-14 MirTarget;miRNATAP -0.102945227946824 0.000137507846802184 NA NA NA hsa-miR-181d-5p RAD21 1.00720380524132 6.04219503683814e-14 -0.443580185174969 9.51779143683762e-14 MirTarget -0.118716536206246 8.30398989086846e-07 NA NA NA hsa-miR-25-3p RAD21 1.12016166564779 3.79069348635778e-48 -0.443580185174969 9.51779143683762e-14 MirTarget;miRNATAP -0.153301911220337 5.9184677873011e-05 NA NA NA hsa-miR-125a-3p RB1 -0.372794471295036 0.000941729459601642 0.321564992682723 1.75209822130765e-05 miRanda -0.121425771058151 0.000995039581971182 NA NA NA hsa-miR-26a-5p RB1 -0.202091714279613 0.00166918288801054 0.321564992682723 1.75209822130765e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.207430706570863 0.00159489645428223 NA NA NA hsa-miR-361-5p RB1 0.0514169367202078 0.382929376393199 0.321564992682723 1.75209822130765e-05 miRanda -0.306658410898847 2.10740981512084e-05 NA NA NA hsa-miR-429 RBL1 -2.16569233119434 2.66862243626443e-37 0.0989106847216323 0.400055925282616 MirTarget -0.137109204916932 4.64418613395965e-05 NA NA NA hsa-miR-106b-5p RBL2 1.07509411417907 2.11739194181878e-36 -0.492285158562142 2.31813132529473e-11 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.370917560757112 6.37127430556685e-19 NA NA NA hsa-miR-107 RBL2 0.140046250553248 0.0943611632552367 -0.492285158562142 2.31813132529473e-11 miRanda -0.155017799372169 0.00210561865292678 NA NA NA hsa-miR-1287-5p RBL2 0.499663372173161 1.4044292587176e-07 -0.492285158562142 2.31813132529473e-11 MirTarget -0.236883032023111 3.0825077023416e-08 NA NA NA hsa-miR-140-5p RBL2 0.504309496243674 3.09884038729031e-11 -0.492285158562142 2.31813132529473e-11 miRanda -0.239400032917795 7.83611524570073e-06 NA NA NA hsa-miR-142-5p RBL2 1.88417391525707 1.2096808039882e-27 -0.492285158562142 2.31813132529473e-11 PITA -0.124237906623343 1.13906595959395e-08 NA NA NA hsa-miR-17-5p RBL2 0.494260110870015 3.8348005261e-09 -0.492285158562142 2.31813132529473e-11 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.141253882933366 0.00403048723423738 NA NA NA hsa-miR-23a-3p RBL2 0.761438723382355 4.09310879199257e-27 -0.492285158562142 2.31813132529473e-11 MirTarget -0.258886227782924 2.09768372837682e-06 NA NA NA hsa-miR-421 RBL2 0.313155739887734 0.020433534776003 -0.492285158562142 2.31813132529473e-11 miRanda -0.128406744480631 5.26845191576896e-05 NA NA NA hsa-miR-576-5p RBL2 1.06681109513983 5.69294424466526e-24 -0.492285158562142 2.31813132529473e-11 MirTarget;PITA -0.109837520221925 0.0029080433374465 NA NA NA hsa-miR-590-3p RBL2 1.13702599385212 3.53435739887793e-22 -0.492285158562142 2.31813132529473e-11 miRanda -0.165301307575792 5.43802998487753e-07 NA NA NA hsa-miR-93-5p RBL2 1.37365940377595 2.37567548683245e-46 -0.492285158562142 2.31813132529473e-11 MirTarget;miRNATAP -0.16444904218248 1.13432071033444e-05 NA NA NA hsa-miR-139-5p RBX1 -0.704802495091118 2.36904108453776e-06 0.297788237367175 1.0599388303487e-05 miRanda -0.155038438111231 1.54107038013013e-10 NA NA NA hsa-miR-532-3p SFN -1.759223962964 7.9077916669414e-40 -0.0565106427263127 0.85264396204226 miRNATAP -0.304358105577632 0.00618834731199983 NA NA NA hsa-miR-130b-3p SKP1 1.12788913578446 2.939369462276e-16 -0.381098934914684 1.76040032439263e-12 MirTarget -0.152738841764484 9.68738568000021e-14 NA NA NA hsa-miR-26a-5p SKP2 -0.202091714279613 0.00166918288801054 0.33908833220841 2.31282152637996e-06 MirTarget -0.21492974375992 0.000655252365405759 NA NA NA hsa-miR-30a-5p SKP2 -0.778411951775343 2.73322451127932e-16 0.33908833220841 2.31282152637996e-06 MirTarget;miRNATAP -0.254627767190772 9.91098299780312e-11 NA NA NA hsa-miR-30b-5p SKP2 -1.18330589477119 6.8341618466966e-27 0.33908833220841 2.31282152637996e-06 MirTarget;miRNATAP -0.189586086768689 8.42780942098384e-09 NA NA NA hsa-miR-30c-5p SKP2 -1.08783070774238 2.02505402525786e-24 0.33908833220841 2.31282152637996e-06 MirTarget;miRNATAP -0.174296135182518 4.38960773093815e-07 NA NA NA hsa-miR-106b-5p SMAD2 1.07509411417907 2.11739194181878e-36 -0.323525857741032 2.23720043114496e-11 mirMAP -0.227921158638246 1.08811372967107e-16 NA NA NA hsa-miR-142-5p SMAD2 1.88417391525707 1.2096808039882e-27 -0.323525857741032 2.23720043114496e-11 mirMAP;miRNATAP -0.103618518834479 1.24250681485868e-13 NA NA NA hsa-miR-148b-3p SMAD2 0.346011252093377 4.27203463315056e-06 -0.323525857741032 2.23720043114496e-11 MirTarget;mirMAP -0.159371781791692 9.32204012025227e-06 NA NA NA hsa-miR-181a-5p SMAD2 1.11111114875339 3.97880443756442e-29 -0.323525857741032 2.23720043114496e-11 mirMAP -0.111196305883891 9.05817772311089e-06 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 1.49054296272357 3.69051660739368e-41 -0.323525857741032 2.23720043114496e-11 mirMAP -0.121061562672026 1.31421344246454e-08 NA NA NA hsa-miR-186-5p SMAD2 0.507217561043443 9.04455748270995e-10 -0.323525857741032 2.23720043114496e-11 mirMAP -0.119891748076015 0.000207363898523546 NA NA NA hsa-miR-28-3p SMAD2 1.01277915413238 1.8655970171461e-43 -0.323525857741032 2.23720043114496e-11 mirMAP -0.161662869809801 6.30266644116871e-07 NA NA NA hsa-miR-361-3p SMAD2 1.08992546227594 1.13197240706704e-36 -0.323525857741032 2.23720043114496e-11 miRNATAP -0.164501760249365 3.64651837826174e-09 22675530 Functional analyses showed that Smad2 and TGFß1 are not dysregulated by miR-361-3p and miR-625* in the lung cell line A549 respectively lung cancer hsa-miR-361-5p SMAD2 0.0514169367202078 0.382929376393199 -0.323525857741032 2.23720043114496e-11 MirTarget -0.143014051357446 0.00265133449369938 NA NA NA hsa-miR-3613-5p SMAD2 1.6648190889407 3.78720979041391e-41 -0.323525857741032 2.23720043114496e-11 mirMAP -0.131514745649209 3.84595509882195e-12 NA NA NA hsa-miR-374a-3p SMAD2 1.13863935833993 2.79089304015401e-44 -0.323525857741032 2.23720043114496e-11 mirMAP -0.1697571733512 3.62987531624032e-09 NA NA NA hsa-miR-374a-5p SMAD2 0.543061152108237 2.19403097299769e-14 -0.323525857741032 2.23720043114496e-11 MirTarget -0.153917787865928 3.39287856117158e-05 NA NA NA hsa-miR-455-5p SMAD2 0.773674551205946 2.12957541541474e-09 -0.323525857741032 2.23720043114496e-11 miRanda -0.10107849465895 7.22542945679077e-07 NA NA NA hsa-miR-484 SMAD2 0.571987778099603 9.67278224458421e-10 -0.323525857741032 2.23720043114496e-11 miRNAWalker2_validate -0.114497326283267 5.78354380226944e-05 NA NA NA hsa-miR-590-3p SMAD2 1.13702599385212 3.53435739887793e-22 -0.323525857741032 2.23720043114496e-11 MirTarget;PITA;mirMAP;miRNATAP -0.103830667568495 1.50902215009462e-06 NA NA NA hsa-miR-769-5p SMAD2 0.376837385738096 4.45440414144944e-07 -0.323525857741032 2.23720043114496e-11 MirTarget;PITA;miRNATAP -0.110502416552027 0.0024196210430541 NA NA NA hsa-miR-15a-5p SMAD3 1.42663930007845 1.36006952074963e-57 -0.244139438487666 3.92004830247932e-05 MirTarget -0.146828051928466 1.64894295267973e-06 NA NA NA hsa-miR-185-5p SMAD3 1.05056378692621 1.31174187880682e-22 -0.244139438487666 3.92004830247932e-05 MirTarget -0.120508170275662 2.37794014383956e-05 NA NA NA hsa-miR-186-5p SMAD3 0.507217561043443 9.04455748270995e-10 -0.244139438487666 3.92004830247932e-05 mirMAP -0.123358679164461 0.00159252671121764 NA NA NA hsa-miR-28-5p SMAD3 0.461962042257226 3.32424690573327e-11 -0.244139438487666 3.92004830247932e-05 miRNATAP -0.19375315100781 2.75344519177763e-05 NA NA NA hsa-miR-330-5p SMAD3 1.44960468659754 2.12131210588035e-45 -0.244139438487666 3.92004830247932e-05 miRanda -0.113884725915202 4.1000924834805e-05 NA NA NA hsa-miR-106b-5p SMAD4 1.07509411417907 2.11739194181878e-36 -0.353252154932229 3.49222750370295e-11 mirMAP;miRNATAP -0.263637533078296 2.2876546815193e-18 NA NA NA hsa-miR-130b-3p SMAD4 1.12788913578446 2.939369462276e-16 -0.353252154932229 3.49222750370295e-11 miRNAWalker2_validate;miRNATAP -0.162522896714783 4.30068548257445e-16 NA NA NA hsa-miR-140-5p SMAD4 0.504309496243674 3.09884038729031e-11 -0.353252154932229 3.49222750370295e-11 miRanda -0.107841915991596 0.00567505288961576 NA NA NA hsa-miR-142-5p SMAD4 1.88417391525707 1.2096808039882e-27 -0.353252154932229 3.49222750370295e-11 mirMAP -0.124573552703085 3.87297476256703e-16 NA NA NA hsa-miR-146b-5p SMAD4 1.40714170253819 2.9559871816487e-12 -0.353252154932229 3.49222750370295e-11 PITA;miRanda;miRNATAP -0.111309409867936 7.89967750234915e-16 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-17-5p SMAD4 0.494260110870015 3.8348005261e-09 -0.353252154932229 3.49222750370295e-11 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.10418923812489 0.00325465373100142 NA NA NA hsa-miR-186-5p SMAD4 0.507217561043443 9.04455748270995e-10 -0.353252154932229 3.49222750370295e-11 miRNAWalker2_validate;mirMAP -0.177554906278362 5.12602285863497e-07 NA NA NA hsa-miR-18a-5p SMAD4 0.936704393213466 1.05064580570579e-10 -0.353252154932229 3.49222750370295e-11 miRNAWalker2_validate -0.128383600075071 6.85100350670596e-11 NA NA NA hsa-miR-21-3p SMAD4 1.78837590049697 1.41655409877312e-33 -0.353252154932229 3.49222750370295e-11 mirMAP -0.14165903491177 7.06231943439386e-16 NA NA NA hsa-miR-25-3p SMAD4 1.12016166564779 3.79069348635778e-48 -0.353252154932229 3.49222750370295e-11 mirMAP -0.170081576681957 4.0925836995647e-07 NA NA NA hsa-miR-27a-3p SMAD4 0.558934437526245 1.44256383086177e-12 -0.353252154932229 3.49222750370295e-11 MirTarget -0.184807695672174 5.04606618085533e-07 NA NA NA hsa-miR-28-3p SMAD4 1.01277915413238 1.8655970171461e-43 -0.353252154932229 3.49222750370295e-11 mirMAP -0.207433269425429 5.47829137446523e-09 NA NA NA hsa-miR-28-5p SMAD4 0.461962042257226 3.32424690573327e-11 -0.353252154932229 3.49222750370295e-11 miRanda;miRNATAP -0.21240385695608 4.4009301490775e-07 NA NA NA hsa-miR-34a-5p SMAD4 1.07544567720768 1.81510842038009e-20 -0.353252154932229 3.49222750370295e-11 miRNATAP -0.1492964045371 4.41797602386054e-10 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-374a-5p SMAD4 0.543061152108237 2.19403097299769e-14 -0.353252154932229 3.49222750370295e-11 mirMAP -0.174206701078802 2.102512853859e-05 NA NA NA hsa-miR-454-3p SMAD4 0.68285296887698 1.17407812677787e-08 -0.353252154932229 3.49222750370295e-11 miRNAWalker2_validate;miRNATAP -0.110750938966582 5.950349811848e-06 NA NA NA hsa-miR-550a-3p SMAD4 1.11969632674498 4.64306608686e-12 -0.353252154932229 3.49222750370295e-11 mirMAP -0.106391130547082 3.02572283040143e-08 NA NA NA hsa-miR-576-5p SMAD4 1.06681109513983 5.69294424466526e-24 -0.353252154932229 3.49222750370295e-11 mirMAP -0.136869509225643 1.80782557368588e-07 NA NA NA hsa-miR-589-5p SMAD4 0.696241532021631 5.26958362886071e-16 -0.353252154932229 3.49222750370295e-11 miRNATAP -0.193467970204694 5.08567008607218e-09 NA NA NA hsa-miR-590-3p SMAD4 1.13702599385212 3.53435739887793e-22 -0.353252154932229 3.49222750370295e-11 MirTarget;PITA;miRanda;miRNATAP -0.131595936977223 2.76221280456342e-08 NA NA NA hsa-miR-590-5p SMAD4 0.709763558412506 1.11883921359361e-11 -0.353252154932229 3.49222750370295e-11 miRanda -0.118750766795147 1.98749735856504e-05 NA NA NA hsa-miR-625-5p SMAD4 0.153090549230629 0.330314026509869 -0.353252154932229 3.49222750370295e-11 MirTarget -0.106797654899829 1.9034803009163e-07 NA NA NA hsa-miR-92b-3p SMAD4 0.418630595140165 6.50466149211154e-05 -0.353252154932229 3.49222750370295e-11 mirMAP -0.15850878585623 1.70467008693526e-08 NA NA NA hsa-miR-93-5p SMAD4 1.37365940377595 2.37567548683245e-46 -0.353252154932229 3.49222750370295e-11 miRNAWalker2_validate;mirMAP;miRNATAP -0.149231105698466 2.4808337153461e-08 NA NA NA hsa-let-7i-5p SMC1A 0.911372377723717 7.11483853341932e-31 -0.275218271123024 1.51263635497579e-05 MirTarget -0.106560412220827 0.00960164149605118 NA NA NA hsa-miR-181c-5p SMC1A 0.762784646696248 4.48373118147729e-10 -0.275218271123024 1.51263635497579e-05 mirMAP -0.117986318774698 2.49624579049679e-05 NA NA NA hsa-miR-27a-3p STAG1 0.558934437526245 1.44256383086177e-12 -0.285453258297697 0.00995562114158228 MirTarget;miRNATAP -0.210250916526419 0.00547789509440399 NA NA NA hsa-miR-140-3p STAG2 0.989350547007025 6.14964028267239e-25 -0.386839199295114 7.64765551737517e-07 MirTarget;PITA;miRNATAP -0.117867696829484 0.0055457905998597 NA NA NA hsa-miR-148a-5p STAG2 0.415500302855613 0.000691460831436767 -0.386839199295114 7.64765551737517e-07 MirTarget;miRNATAP -0.125356174592136 0.000410250921788399 NA NA NA hsa-miR-181a-5p STAG2 1.11111114875339 3.97880443756442e-29 -0.386839199295114 7.64765551737517e-07 miRNAWalker2_validate -0.145304303372635 0.000316411203892507 NA NA NA hsa-miR-21-5p STAG2 2.51462371613332 3.30620591950316e-66 -0.386839199295114 7.64765551737517e-07 miRNAWalker2_validate;MirTarget;miRNATAP -0.142564822685437 2.15242158795453e-09 NA NA NA hsa-miR-22-3p STAG2 0.198460552200729 0.00761005672059428 -0.386839199295114 7.64765551737517e-07 MirTarget;miRNATAP -0.337879584208107 7.01675669120302e-09 NA NA NA hsa-miR-34a-5p STAG2 1.07544567720768 1.81510842038009e-20 -0.386839199295114 7.64765551737517e-07 miRNAWalker2_validate;miRNATAP -0.112505755806979 0.00153437714152558 NA NA NA hsa-miR-590-3p STAG2 1.13702599385212 3.53435739887793e-22 -0.386839199295114 7.64765551737517e-07 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.139394768035302 6.10228709093681e-05 NA NA NA hsa-miR-590-5p STAG2 0.709763558412506 1.11883921359361e-11 -0.386839199295114 7.64765551737517e-07 MirTarget;PITA;miRanda;miRNATAP -0.132838277264276 0.00107970150543889 NA NA NA hsa-miR-92b-3p STAG2 0.418630595140165 6.50466149211154e-05 -0.386839199295114 7.64765551737517e-07 miRNATAP -0.151553556958282 0.000249370042647913 NA NA NA hsa-miR-28-5p TFDP1 0.461962042257226 3.32424690573327e-11 -0.250757367951207 2.69008707290681e-06 miRanda -0.120902476660672 0.00398231847613473 NA NA NA hsa-miR-339-5p TFDP1 0.322848334531193 0.0117281778821612 -0.250757367951207 2.69008707290681e-06 miRanda -0.101951843009526 9.07622215982904e-06 NA NA NA hsa-miR-365a-3p TFDP1 0.80809616164259 2.36039522526e-12 -0.250757367951207 2.69008707290681e-06 MirTarget -0.126291709783627 2.91875011948722e-07 NA NA NA hsa-miR-590-3p TFDP1 1.13702599385212 3.53435739887793e-22 -0.250757367951207 2.69008707290681e-06 MirTarget;PITA;miRanda -0.103302175204772 1.14768125112577e-05 NA NA NA hsa-miR-101-3p TFDP2 0.683973909682285 2.88573524246948e-15 -0.977232326962993 7.49243967243821e-30 mirMAP -0.365777367662517 9.50298696584048e-11 NA NA NA hsa-miR-126-5p TFDP2 0.785607261431085 5.77058629454465e-13 -0.977232326962993 7.49243967243821e-30 mirMAP -0.251091173241783 3.24956231302937e-08 NA NA NA hsa-miR-1271-5p TFDP2 0.900599702972936 3.07963385418853e-10 -0.977232326962993 7.49243967243821e-30 MirTarget;mirMAP -0.153171008289069 1.30080960256555e-05 NA NA NA hsa-miR-130b-5p TFDP2 0.92990617673277 3.75880436852717e-12 -0.977232326962993 7.49243967243821e-30 mirMAP -0.153135710141742 4.20982947852262e-05 NA NA NA hsa-miR-132-3p TFDP2 0.291409674711894 0.000912684337101876 -0.977232326962993 7.49243967243821e-30 mirMAP -0.237190626916684 5.89944717190971e-05 NA NA NA hsa-miR-143-3p TFDP2 0.544259011512089 1.71102635165867e-05 -0.977232326962993 7.49243967243821e-30 mirMAP -0.208873282943681 1.97223931919994e-07 NA NA NA hsa-miR-146a-5p TFDP2 1.04938133739924 7.51013231709992e-12 -0.977232326962993 7.49243967243821e-30 MirTarget -0.101713617952847 0.00195164162009007 NA NA NA hsa-miR-155-5p TFDP2 3.26274490570809 5.06841441826518e-51 -0.977232326962993 7.49243967243821e-30 miRNATAP -0.178540654271453 1.56724700923094e-20 NA NA NA hsa-miR-15a-5p TFDP2 1.42663930007845 1.36006952074963e-57 -0.977232326962993 7.49243967243821e-30 MirTarget -0.441662088048508 7.87451293251404e-22 NA NA NA hsa-miR-15b-5p TFDP2 0.773001494057531 1.71784656078957e-16 -0.977232326962993 7.49243967243821e-30 MirTarget;mirMAP -0.203537751794486 0.000120734300204605 NA NA NA hsa-miR-16-1-3p TFDP2 1.51429140700091 3.17219833254498e-37 -0.977232326962993 7.49243967243821e-30 mirMAP -0.250827509317585 8.85217791514145e-11 NA NA NA hsa-miR-16-2-3p TFDP2 1.3046118743965 4.17207934608428e-19 -0.977232326962993 7.49243967243821e-30 mirMAP -0.163608611103406 8.70890364125804e-07 NA NA NA hsa-miR-16-5p TFDP2 0.934012514027655 4.85417898318515e-24 -0.977232326962993 7.49243967243821e-30 MirTarget;mirMAP -0.29792543494628 8.2776107431179e-09 NA NA NA hsa-miR-17-3p TFDP2 0.723795600017259 5.90151677164931e-18 -0.977232326962993 7.49243967243821e-30 MirTarget -0.416855130291657 3.89645024132602e-13 NA NA NA hsa-miR-181a-2-3p TFDP2 0.549613348249471 1.48987286432989e-10 -0.977232326962993 7.49243967243821e-30 mirMAP -0.282187808724268 1.61153162481419e-06 NA NA NA hsa-miR-186-5p TFDP2 0.507217561043443 9.04455748270995e-10 -0.977232326962993 7.49243967243821e-30 MirTarget;mirMAP -0.212711076176595 0.000565175820934467 NA NA NA hsa-miR-195-3p TFDP2 0.808592887366705 6.8151241038711e-09 -0.977232326962993 7.49243967243821e-30 mirMAP -0.127986912964694 0.000481931524642601 NA NA NA hsa-miR-195-5p TFDP2 0.346502644882604 0.0092562828415903 -0.977232326962993 7.49243967243821e-30 MirTarget;mirMAP -0.152565760812937 8.55938956655904e-05 NA NA NA hsa-miR-19a-3p TFDP2 0.722913586880779 2.76301458932381e-10 -0.977232326962993 7.49243967243821e-30 MirTarget -0.283701402659586 5.06952745388041e-11 NA NA NA hsa-miR-19b-3p TFDP2 0.195940928879427 0.0300512922542325 -0.977232326962993 7.49243967243821e-30 MirTarget -0.28711001046558 5.42255105969601e-07 NA NA NA hsa-miR-224-3p TFDP2 0.918780460857403 2.47005991706282e-07 -0.977232326962993 7.49243967243821e-30 mirMAP -0.126727856600008 1.72235777201819e-05 NA NA NA hsa-miR-224-5p TFDP2 2.84654230414912 3.0480927226395e-47 -0.977232326962993 7.49243967243821e-30 mirMAP -0.187252129186353 4.44979124904126e-18 NA NA NA hsa-miR-2355-5p TFDP2 1.57515081110162 3.54962327490702e-48 -0.977232326962993 7.49243967243821e-30 mirMAP -0.342559563305066 4.22655224658634e-18 NA NA NA hsa-miR-23a-3p TFDP2 0.761438723382355 4.09310879199257e-27 -0.977232326962993 7.49243967243821e-30 mirMAP -0.497672671771747 5.76728185342838e-14 NA NA NA hsa-miR-25-3p TFDP2 1.12016166564779 3.79069348635778e-48 -0.977232326962993 7.49243967243821e-30 MirTarget;miRNATAP -0.544643753486824 3.58285299274111e-23 NA NA NA hsa-miR-27a-3p TFDP2 0.558934437526245 1.44256383086177e-12 -0.977232326962993 7.49243967243821e-30 mirMAP -0.400583215237248 1.76540867932909e-10 NA NA NA hsa-miR-32-5p TFDP2 0.407826130035097 7.26884631998646e-06 -0.977232326962993 7.49243967243821e-30 MirTarget;mirMAP;miRNATAP -0.156923360466036 0.00590310411108496 NA NA NA hsa-miR-320a TFDP2 0.412740558379182 2.02929519701706e-05 -0.977232326962993 7.49243967243821e-30 mirMAP -0.227612411590301 1.79558612212048e-05 NA NA NA hsa-miR-320b TFDP2 0.300497419754843 0.0245219177384172 -0.977232326962993 7.49243967243821e-30 mirMAP -0.138384600928737 0.000365546802326979 NA NA NA hsa-miR-338-3p TFDP2 0.906250377628867 2.76970900371139e-15 -0.977232326962993 7.49243967243821e-30 mirMAP -0.234328473739503 4.46242556412444e-08 NA NA NA hsa-miR-340-5p TFDP2 1.14479851941741 2.91936881701444e-15 -0.977232326962993 7.49243967243821e-30 mirMAP -0.178827309577185 1.26251650032848e-07 NA NA NA hsa-miR-342-3p TFDP2 1.4124432570595 1.07208971556131e-28 -0.977232326962993 7.49243967243821e-30 miRNATAP -0.263156261291083 4.10153141282971e-13 NA NA NA hsa-miR-34a-5p TFDP2 1.07544567720768 1.81510842038009e-20 -0.977232326962993 7.49243967243821e-30 miRNATAP -0.23006717698394 3.18025054045306e-08 NA NA NA hsa-miR-365a-3p TFDP2 0.80809616164259 2.36039522526e-12 -0.977232326962993 7.49243967243821e-30 mirMAP -0.234487301928269 5.14025324784378e-08 NA NA NA hsa-miR-542-3p TFDP2 0.431147917094433 0.000254981247606435 -0.977232326962993 7.49243967243821e-30 mirMAP -0.139331470157665 0.00150065567326825 NA NA NA hsa-miR-584-5p TFDP2 2.09455345496517 1.01738783798409e-51 -0.977232326962993 7.49243967243821e-30 mirMAP -0.264144979886678 3.62840907499298e-18 NA NA NA hsa-miR-590-3p TFDP2 1.13702599385212 3.53435739887793e-22 -0.977232326962993 7.49243967243821e-30 mirMAP -0.301894044250802 5.27979268682576e-14 NA NA NA hsa-miR-629-3p TFDP2 1.09330044556689 2.9533160808356e-14 -0.977232326962993 7.49243967243821e-30 MirTarget -0.151913799906575 1.50034295999907e-05 NA NA NA hsa-miR-769-5p TFDP2 0.376837385738096 4.45440414144944e-07 -0.977232326962993 7.49243967243821e-30 mirMAP;miRNATAP -0.181216003292524 0.00920028877830766 NA NA NA hsa-miR-92a-3p TFDP2 0.178194888895831 0.0088835082650834 -0.977232326962993 7.49243967243821e-30 MirTarget;miRNATAP -0.345424067125417 6.99755902852545e-06 NA NA NA hsa-miR-92b-3p TFDP2 0.418630595140165 6.50466149211154e-05 -0.977232326962993 7.49243967243821e-30 MirTarget;miRNATAP -0.228220637148703 3.07761384066781e-06 NA NA NA hsa-miR-139-5p TGFB1 -0.704802495091118 2.36904108453776e-06 1.54700279831576 2.78812914754058e-38 miRanda -0.229663915619583 2.28216718397939e-06 NA NA NA hsa-miR-744-5p TGFB1 -0.348985243196771 0.000187889982228835 1.54700279831576 2.78812914754058e-38 miRNAWalker2_validate;miRNATAP -0.399940904532963 3.45780106724256e-07 NA NA NA hsa-miR-107 TGFB2 0.140046250553248 0.0943611632552367 -0.469336292045935 0.000490251477006724 miRanda -0.559933447086514 2.03481629875917e-10 NA NA NA hsa-miR-130b-3p TGFB2 1.12788913578446 2.939369462276e-16 -0.469336292045935 0.000490251477006724 MirTarget;miRNATAP -0.156580751578969 0.00249097420975105 NA NA NA hsa-miR-142-5p TGFB2 1.88417391525707 1.2096808039882e-27 -0.469336292045935 0.000490251477006724 mirMAP -0.127254748923374 0.00130803131995633 NA NA NA hsa-miR-148a-3p TGFB2 0.343233211643815 0.00402279073598165 -0.469336292045935 0.000490251477006724 MirTarget;miRNATAP -0.246846036181106 7.29697456550998e-05 NA NA NA hsa-miR-148b-3p TGFB2 0.346011252093377 4.27203463315056e-06 -0.469336292045935 0.000490251477006724 MirTarget -0.360468526268224 0.000268375188449583 NA NA NA hsa-miR-193b-3p TGFB2 -0.273325765316079 0.104328826585392 -0.469336292045935 0.000490251477006724 MirTarget;miRNATAP -0.167973598355945 0.000145171044419197 NA NA NA hsa-miR-21-5p TGFB2 2.51462371613332 3.30620591950316e-66 -0.469336292045935 0.000490251477006724 miRNAWalker2_validate -0.131173211686422 0.00157690783662872 NA NA NA hsa-miR-29b-3p TGFB2 -0.228125979913806 0.0271621721891603 -0.469336292045935 0.000490251477006724 miRTarBase;MirTarget;miRNATAP -0.289170386615493 6.28377322853352e-05 NA NA NA hsa-miR-331-5p TGFB2 0.661186030542026 1.83628790002785e-08 -0.469336292045935 0.000490251477006724 miRNATAP -0.235323703080359 0.000288389309217486 NA NA NA hsa-miR-361-5p TGFB2 0.0514169367202078 0.382929376393199 -0.469336292045935 0.000490251477006724 miRNATAP -0.593277310323935 4.29304373395412e-06 NA NA NA hsa-miR-362-3p TGFB2 -0.753214251798232 3.0025661608035e-07 -0.469336292045935 0.000490251477006724 miRanda -0.151802483500752 0.00324883313613339 NA NA NA hsa-miR-374b-5p TGFB2 0.0804104684417872 0.365593963035077 -0.469336292045935 0.000490251477006724 mirMAP -0.302286565852539 0.000359174717531722 NA NA NA hsa-miR-454-3p TGFB2 0.68285296887698 1.17407812677787e-08 -0.469336292045935 0.000490251477006724 MirTarget;miRNATAP -0.186190333634062 0.00234395713860443 NA NA NA hsa-miR-590-3p TGFB2 1.13702599385212 3.53435739887793e-22 -0.469336292045935 0.000490251477006724 mirMAP -0.293207073092184 6.78797834982813e-07 NA NA NA hsa-miR-590-5p TGFB2 0.709763558412506 1.11883921359361e-11 -0.469336292045935 0.000490251477006724 miRanda;miRNATAP -0.256415439338522 0.000214547512438195 NA NA NA hsa-miR-616-5p TGFB2 0.913426384742148 3.78418389333709e-09 -0.469336292045935 0.000490251477006724 mirMAP -0.229064681057646 1.30218112799715e-06 NA NA NA hsa-miR-10a-5p TGFB3 -1.17164272592931 4.86621098042279e-24 0.891364650319448 3.84674758127802e-13 miRNAWalker2_validate -0.195492012609065 0.000520343467974493 NA NA NA hsa-miR-29b-3p TGFB3 -0.228125979913806 0.0271621721891603 0.891364650319448 3.84674758127802e-13 miRTarBase -0.21513711549002 0.00161883134704875 NA NA NA hsa-miR-10b-5p TP53 -0.89971464210447 1.18190532299934e-20 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate;miRTarBase -0.178289673371273 1.01311520211069e-07 NA NA NA hsa-miR-125a-5p TP53 -0.561874059994802 7.3931856356891e-13 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate;miRTarBase;miRanda -0.169369198879199 8.24720080675124e-05 26389681;21777146;23079745 Mechanistically inactivation of miR-125a during cervical carcinogenesis was caused by HPV suppression of p53 expression;In addition wild-type p53 mRNA and protein expression was increased by hsa-miR-125a-5p overexpression; Moreover blocking wild-type p53 attenuated the effect of hsa-miR-125a-5p on apoptosis; In loss-of-function experiments wild-type p53 mRNA and protein expression was decreased by blocking hsa-miR-125a-5p; The effect of hsa-miR-125a-5p inhibitor on apoptosis was also weakened by blocking wild-type p53;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity tumorigenesis;; cervical and endocervical cancer;lung cancer;liver cancer hsa-miR-125b-5p TP53 -0.825456421494266 2.13029877878434e-15 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate;miRTarBase -0.164499575889924 1.96885947372224e-07 24846940;26335100;24137477;26686386;24402874;21399871;23585871;24762088;24169356;23079745 The results revealed that hsa-miR-125b may regulate multiple biological processes and signal transduction pathways and drug-resistant occurrence is associated with cell proliferation cell apoptosis cell cycle and signaling pathways including MAPK Wnt and p53;The carboxy terminal domain of connexin 43 CT Cx43 modulates the expression of p53 by altering miR 125b expression in low grade human breast cancers; In addition CT-Cx43 was exogenously expressed in the breast cancer-derived cell line MCF-7 and its effect on the expression of miR-125b and its downstream target p53 were evaluated as well as its effect on cellular proliferation and death using MTT and LDH assays respectively; Interestingly we found that miR-125b a negative regulator of p53 exhibited an inverse expression relationship with CT-Cx43 in the breast cancer samples tested;TP53 and hsa-miR-125b were observed to form a self-adaptation association;In this study we have investigated the delivery and transfection of wild-type wt- p53 and microRNA-125b miR-125b expressing plasmid DNA in SK-LU-1 human lung adenocarcinoma cells as well as in KrasG12D/p53fl/fl KP genetically engineered mouse model of lung cancer;miR-34a is directly regulated by p53 and acts as tumor suppressor while miR-125b plays a significant role in immune response and apoptosis;In vitro assays revealed that overexpression of miR-125b repressed the endogenous level of p53 protein in human colorectal cancer cells;In this study we further extend our studies by showing that miR-125b represses the protein product of the ink4a/ARF locus p14ARF in two prostate cancer cell lines LNCaP wild type-p53 and 22Rv1 both wild type and mutant p53 as well as in the PC-346C prostate cancer xenograft model that lentivirally overexpressed miR-125b;A stable overexpression of miR-125b in human melanoma cell line Mel-Juso resulted in a G0/G1 cell cycle block and emergence of large cells expressing senescence markers: senescence-associated beta-galactosidase p21 p27 and p53;MiR 125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK independent pathways; Further studies reveal that p53 is regulated by miR-125b; However downregulation of the endogenous miR-125b also results in p53-independent apoptotic pathway leading to apoptosis in p53 mutated U251 cells and p53 knockdown U87 cells;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity; To show the clinical significance of these findings mutations in the DNA binding domain of p53 and promoter methylation of miR-125b were investigated; Four out of nine patients with induced SIRT7 carried mutations in the p53 gene and one patient showed hypermethylation of the miR-125b promoter region ;;;;immune resistance;;;;; gastric cancer;breast cancer;pancreatic cancer;lung cancer;cervical and endocervical cancer;colorectal cancer;prostate cancer;melanoma;glioblastoma;liver cancer hsa-miR-30d-5p TP53 -0.202727675788184 0.00659067084745794 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate -0.234010250909245 4.72794888119438e-07 NA NA NA hsa-miR-125a-3p TTK -0.372794471295036 0.000941729459601642 2.09615460114404 4.96001647028033e-31 miRanda -0.288979822138491 0.00305770774569803 NA NA NA hsa-miR-139-5p TTK -0.704802495091118 2.36904108453776e-06 2.09615460114404 4.96001647028033e-31 miRanda -0.448892753683503 2.43294028173915e-10 NA NA NA hsa-let-7a-3p WEE1 0.0677487960013088 0.460458477653989 -0.636963209253611 1.02026165449518e-08 mirMAP;miRNATAP -0.291869437772069 2.01573977070449e-05 NA NA NA hsa-miR-103a-3p WEE1 0.779373475434461 7.37867196796994e-20 -0.636963209253611 1.02026165449518e-08 miRNAWalker2_validate -0.239192350513036 0.000579708121394736 NA NA NA hsa-miR-106b-5p WEE1 1.07509411417907 2.11739194181878e-36 -0.636963209253611 1.02026165449518e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.365347091655056 1.78673370823498e-08 NA NA NA hsa-miR-107 WEE1 0.140046250553248 0.0943611632552367 -0.636963209253611 1.02026165449518e-08 miRanda -0.371523293952251 6.66314407072104e-07 NA NA NA hsa-miR-128-3p WEE1 0.475045893035043 2.6255647468e-06 -0.636963209253611 1.02026165449518e-08 miRNAWalker2_validate;miRTarBase;MirTarget -0.216755901935243 0.000403005535512462 NA NA NA hsa-miR-130b-3p WEE1 1.12788913578446 2.939369462276e-16 -0.636963209253611 1.02026165449518e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.18673108217859 1.47414599939286e-05 NA NA NA hsa-miR-130b-5p WEE1 0.92990617673277 3.75880436852717e-12 -0.636963209253611 1.02026165449518e-08 miRNAWalker2_validate -0.208976002897575 3.19325249292422e-06 NA NA NA hsa-miR-140-5p WEE1 0.504309496243674 3.09884038729031e-11 -0.636963209253611 1.02026165449518e-08 PITA;miRanda -0.265047143062388 0.00105374605992535 NA NA NA hsa-miR-146b-5p WEE1 1.40714170253819 2.9559871816487e-12 -0.636963209253611 1.02026165449518e-08 miRanda -0.110422505026309 0.000219426132735302 NA NA NA hsa-miR-155-5p WEE1 3.26274490570809 5.06841441826518e-51 -0.636963209253611 1.02026165449518e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.13513339725962 2.12382036339658e-08 NA NA NA hsa-miR-15a-5p WEE1 1.42663930007845 1.36006952074963e-57 -0.636963209253611 1.02026165449518e-08 MirTarget;miRNATAP -0.336724821946034 5.94431966280295e-09 NA NA NA hsa-miR-15b-5p WEE1 0.773001494057531 1.71784656078957e-16 -0.636963209253611 1.02026165449518e-08 MirTarget;miRNATAP -0.264748436152497 3.18126279362652e-05 NA NA NA hsa-miR-16-1-3p WEE1 1.51429140700091 3.17219833254498e-37 -0.636963209253611 1.02026165449518e-08 MirTarget -0.265636805141999 1.51998471222327e-08 NA NA NA hsa-miR-16-5p WEE1 0.934012514027655 4.85417898318515e-24 -0.636963209253611 1.02026165449518e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.296149512515043 2.39924722367025e-06 NA NA NA hsa-miR-186-5p WEE1 0.507217561043443 9.04455748270995e-10 -0.636963209253611 1.02026165449518e-08 miRNAWalker2_validate -0.233355430395898 0.00171581863516654 NA NA NA hsa-miR-192-3p WEE1 0.156650099616707 0.483496040900362 -0.636963209253611 1.02026165449518e-08 MirTarget -0.123105813215133 1.07854843798488e-05 NA NA NA hsa-miR-195-5p WEE1 0.346502644882604 0.0092562828415903 -0.636963209253611 1.02026165449518e-08 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.146314630823581 0.00184528600613705 22847610 Regulation of cell cycle checkpoint kinase WEE1 by miR 195 in malignant melanoma; Moreover there was an inverse correlation between the expression of WEE1 and WEE1-targeting microRNA miR-195; Further analyses showed that transfection of melanoma cell lines with miR-195 indeed reduced WEE1 mRNA and protein expression in these cells; Reporter gene analysis confirmed direct targeting of the WEE1 3' untranslated region 3'UTR by miR-195; Overexpression of miR-195 in SK-Mel-28 melanoma cells was accompanied by WEE1 reduction and significantly reduced stress-induced G2-M cell cycle arrest which could be restored by stable overexpression of WEE1; Moreover miR-195 overexpression and WEE1 knockdown respectively increased melanoma cell proliferation; Taken together the present study shows that WEE1 expression in malignant melanoma is directly regulated by miR-195 miR-195-mediated downregulation of WEE1 in metastatic lesions may help to overcome cell cycle arrest under stress conditions in the local tissue microenvironment to allow unrestricted growth of tumour cells malignant trasformation melanoma hsa-miR-221-3p WEE1 0.337895669520713 0.0136448974691037 -0.636963209253611 1.02026165449518e-08 miRNAWalker2_validate -0.121070035790275 0.00816431333963384 NA NA NA hsa-miR-27a-3p WEE1 0.558934437526245 1.44256383086177e-12 -0.636963209253611 1.02026165449518e-08 miRTarBase;MirTarget -0.352380492083961 4.41185717887668e-06 NA NA NA hsa-miR-361-5p WEE1 0.0514169367202078 0.382929376393199 -0.636963209253611 1.02026165449518e-08 miRanda -0.424423786217586 9.48781726537294e-05 NA NA NA hsa-miR-421 WEE1 0.313155739887734 0.020433534776003 -0.636963209253611 1.02026165449518e-08 miRanda -0.153464212300192 0.00134239255647786 NA NA NA hsa-miR-484 WEE1 0.571987778099603 9.67278224458421e-10 -0.636963209253611 1.02026165449518e-08 miRNAWalker2_validate -0.323585699508408 6.26429795763822e-07 NA NA NA hsa-miR-497-5p WEE1 0.227757383708836 0.0600073987853074 -0.636963209253611 1.02026165449518e-08 MirTarget;miRNATAP -0.193712920755027 0.000177735990572963 NA NA NA hsa-miR-590-3p WEE1 1.13702599385212 3.53435739887793e-22 -0.636963209253611 1.02026165449518e-08 miRanda -0.19829962367788 6.92884853535201e-05 NA NA NA hsa-miR-93-5p WEE1 1.37365940377595 2.37567548683245e-46 -0.636963209253611 1.02026165449518e-08 miRNATAP -0.201653885434693 0.000355754883685841 NA NA NA hsa-miR-181a-5p YWHAB 1.11111114875339 3.97880443756442e-29 -0.436649879556757 1.07574819649047e-17 mirMAP -0.157430815606491 3.72850286786433e-09 NA NA NA hsa-miR-181b-5p YWHAB 1.49054296272357 3.69051660739368e-41 -0.436649879556757 1.07574819649047e-17 mirMAP -0.148555433994048 7.04256501112272e-11 NA NA NA hsa-miR-27a-3p YWHAB 0.558934437526245 1.44256383086177e-12 -0.436649879556757 1.07574819649047e-17 MirTarget;miRNATAP -0.140096204677841 0.000109347058006503 NA NA NA hsa-miR-28-3p YWHAB 1.01277915413238 1.8655970171461e-43 -0.436649879556757 1.07574819649047e-17 mirMAP -0.128268747523935 0.000279381491821486 NA NA NA hsa-miR-590-3p YWHAB 1.13702599385212 3.53435739887793e-22 -0.436649879556757 1.07574819649047e-17 miRanda -0.114186720944627 9.10728186010718e-07 NA NA NA hsa-miR-140-5p YWHAE 0.504309496243674 3.09884038729031e-11 -0.126291713961324 0.00146652744659035 miRanda -0.147589734050215 9.44106228586763e-08 NA NA NA hsa-miR-200a-3p YWHAG -1.43409013664263 2.00188483717828e-20 0.356795537472197 2.99065123952189e-09 MirTarget;miRNATAP -0.108146282995436 8.88223977768603e-08 NA NA NA hsa-miR-200b-3p YWHAG -1.70383252137161 2.38979336321755e-30 0.356795537472197 2.99065123952189e-09 MirTarget;TargetScan -0.109950840688747 6.60623803058959e-08 NA NA NA hsa-miR-23b-3p YWHAG -0.533749586990474 2.46924776953771e-10 0.356795537472197 2.99065123952189e-09 MirTarget;miRNATAP -0.125114895596028 0.00146198575052877 NA NA NA hsa-miR-30a-5p YWHAG -0.778411951775343 2.73322451127932e-16 0.356795537472197 2.99065123952189e-09 miRNATAP -0.244666106319673 1.06273731298785e-13 NA NA NA hsa-miR-30b-5p YWHAG -1.18330589477119 6.8341618466966e-27 0.356795537472197 2.99065123952189e-09 miRNATAP -0.153808500618617 3.37747961935545e-08 NA NA NA hsa-miR-30c-5p YWHAG -1.08783070774238 2.02505402525786e-24 0.356795537472197 2.99065123952189e-09 miRNATAP -0.136382262402707 3.07275349224244e-06 NA NA NA hsa-miR-429 YWHAG -2.16569233119434 2.66862243626443e-37 0.356795537472197 2.99065123952189e-09 MirTarget;PITA;miRanda;miRNATAP -0.103261950591647 2.69299283602683e-09 NA NA NA hsa-miR-324-5p YWHAH -0.487750893426456 3.74472736457965e-05 0.879541909818469 2.70172159291526e-40 miRNAWalker2_validate -0.10780707564178 0.0018544112120671 NA NA NA hsa-miR-33a-5p YWHAH -1.59840463890997 1.13487952314403e-18 0.879541909818469 2.70172159291526e-40 miRNAWalker2_validate;MirTarget;miRNATAP -0.12503282006823 3.8785311230509e-09 NA NA NA hsa-miR-508-3p YWHAH -3.41433288024917 3.47699261121175e-37 0.879541909818469 2.70172159291526e-40 miRNATAP -0.129480004616491 4.79117076373846e-24 NA NA NA hsa-miR-30a-5p YWHAZ -0.778411951775343 2.73322451127932e-16 0.131743827589666 0.0169925785623515 miRNAWalker2_validate;MirTarget;miRNATAP -0.155632407992389 2.42076268396331e-07 NA NA NA hsa-miR-30d-5p YWHAZ -0.202727675788184 0.00659067084745794 0.131743827589666 0.0169925785623515 MirTarget;miRNATAP -0.113720265182448 0.00562868472799409 NA NA NA hsa-miR-361-5p YWHAZ 0.0514169367202078 0.382929376393199 0.131743827589666 0.0169925785623515 miRanda -0.15008979606015 0.00451477624517307 NA NA NA