miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-26a-5p ABCB9 -0.126411409001078 0.440028840408711 1.1211555252781 3.56430803400055e-08 miRNAWalker2_validate -0.323179164736964 2.41625989316895e-08 NA NA NA hsa-miR-26a-5p ACOT11 -0.126411409001078 0.440028840408711 1.18206936219683 1.85135072707042e-06 mirMAP -0.176916830736739 0.0130516339545499 NA NA NA hsa-miR-26a-5p ACTR3B -0.126411409001078 0.440028840408711 0.775489844816537 1.4103336486953e-06 miRNATAP -0.226899144841221 6.95067727988656e-07 NA NA NA hsa-miR-26a-5p ADAM12 -0.126411409001078 0.440028840408711 2.40624900645293 4.34494698353113e-09 mirMAP;miRNATAP -0.505768357416581 1.78713133438295e-05 NA NA NA hsa-miR-26a-5p ADM -0.126411409001078 0.440028840408711 -0.334920125742898 0.318812524968426 miRNAWalker2_validate;MirTarget;miRNATAP -0.356677800138835 0.000177384744692537 NA NA NA hsa-let-7a-5p AIFM1 -1.37014061604018 3.11451492971224e-14 0.701046679657264 4.73210836532952e-09 TargetScan;miRNATAP -0.113097819095147 0.000177982745708989 NA NA NA hsa-let-7b-5p AIFM1 -1.62016148171663 1.56547487335694e-15 0.701046679657264 4.73210836532952e-09 miRNATAP -0.12394893444617 2.99656873665416e-06 NA NA NA hsa-miR-26a-5p AKIRIN1 -0.126411409001078 0.440028840408711 -0.00600804332807403 0.955751507016914 miRNATAP -0.121918241297574 6.25612617773215e-05 NA NA NA hsa-let-7a-5p AKT2 -1.37014061604018 3.11451492971224e-14 0.158500088541505 0.113504798741429 TargetScan -0.119930037553526 1.13227688326527e-06 NA NA NA hsa-miR-29a-3p AKT2 0.101650412194573 0.573201097011668 0.158500088541505 0.113504798741429 MirTarget -0.104368014677354 4.26511869332683e-05 24076586 Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis acute myeloid leukemia hsa-miR-106b-5p AKT3 1.47447672652218 1.32004094930462e-13 -1.44031241124732 2.576504600149e-09 miRNATAP -0.158920731526324 0.00425859940487133 NA NA NA hsa-miR-107 AKT3 0.658676029898313 5.11480446318819e-07 -1.44031241124732 2.576504600149e-09 PITA;miRanda -0.256548300142307 0.00309702957622585 NA NA NA hsa-miR-146b-5p AKT3 1.0922867893808 5.63754607494775e-06 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate -0.14508398550335 0.00188822517544197 NA NA NA hsa-miR-15a-5p AKT3 1.62575353599172 1.55312121019827e-19 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.412918804091755 4.08840965026726e-12 NA NA NA hsa-miR-16-5p AKT3 0.749619098384047 4.11649450706988e-06 -1.44031241124732 2.576504600149e-09 miRNAWalker2_validate;miRTarBase;miRNATAP -0.269698520974258 9.94440318719177e-05 NA NA NA hsa-miR-17-3p AKT3 1.36706429551147 4.60388403547821e-13 -1.44031241124732 2.576504600149e-09 miRNATAP -0.150903286752378 0.0102655088674849 NA NA NA hsa-miR-17-5p AKT3 2.07078488653279 2.77403038572568e-19 -1.44031241124732 2.576504600149e-09 TargetScan;miRNATAP -0.217476886844258 3.56953935954486e-06 NA NA NA hsa-miR-181a-5p AKT3 -0.375429731222937 0.0562142867129802 -1.44031241124732 2.576504600149e-09 miRNATAP -0.22550600060725 9.19470016250579e-05 NA NA NA hsa-miR-181b-5p AKT3 0.668793269169928 0.000239998092406404 -1.44031241124732 2.576504600149e-09 miRNATAP -0.367498754199467 2.09865276667175e-09 NA NA NA hsa-miR-20a-5p AKT3 2.64649625616975 5.1469418982085e-27 -1.44031241124732 2.576504600149e-09 miRNATAP -0.24430728120197 1.27608550819212e-08 NA NA NA hsa-miR-22-3p AKT3 1.42501909916631 1.72295005910055e-25 -1.44031241124732 2.576504600149e-09 miRNATAP -0.259390140878921 0.0010937362716222 NA NA NA hsa-miR-28-3p AKT3 0.387144500601444 0.00777919765254534 -1.44031241124732 2.576504600149e-09 miRNATAP -0.197315516871575 0.0122556173898666 NA NA NA hsa-miR-29a-3p AKT3 0.101650412194573 0.573201097011668 -1.44031241124732 2.576504600149e-09 miRNATAP -0.147280324253872 0.0201558550795979 NA NA NA hsa-miR-29b-2-5p AKT3 0.345881055247341 0.194842633194187 -1.44031241124732 2.576504600149e-09 mirMAP -0.181342398720756 1.80199534450665e-05 NA NA NA hsa-miR-29b-3p AKT3 3.10527711861309 3.01242507282711e-32 -1.44031241124732 2.576504600149e-09 miRNATAP -0.267243460090773 1.17871192498365e-11 26512921 MicroRNA 29B mir 29b regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3 ovarian cancer hsa-miR-3065-5p AKT3 0.653308707552535 0.0999497219778851 -1.44031241124732 2.576504600149e-09 mirMAP -0.18242132898273 2.34990243224026e-09 NA NA NA hsa-miR-335-3p AKT3 1.51116383169018 6.88553098788624e-13 -1.44031241124732 2.576504600149e-09 mirMAP -0.134576700675304 0.0106735082003925 NA NA NA hsa-miR-362-5p AKT3 0.658947634569393 0.0243306847205756 -1.44031241124732 2.576504600149e-09 PITA;TargetScan;miRNATAP -0.229571357984291 4.43564207755877e-09 NA NA NA hsa-miR-542-3p AKT3 1.62226640768239 2.6427102465476e-10 -1.44031241124732 2.576504600149e-09 miRanda -0.186790699816246 1.44501888663791e-05 NA NA NA hsa-miR-93-5p AKT3 1.50844106515467 1.83836866996875e-12 -1.44031241124732 2.576504600149e-09 miRNATAP -0.251105283811718 1.01733106411986e-06 NA NA NA hsa-miR-26a-5p ANKIB1 -0.126411409001078 0.440028840408711 0.472588710913856 7.2680592875853e-05 miRNATAP -0.142383879133015 2.51511966406491e-05 NA NA NA hsa-miR-26a-5p ANKRD52 -0.126411409001078 0.440028840408711 0.435644365596915 0.00335859064191175 mirMAP;miRNATAP -0.188060352525494 7.53466475670721e-06 NA NA NA hsa-miR-23a-3p APAF1 0.111958289789488 0.393086414480463 0.0527330819081095 0.628296064246439 miRNATAP -0.131163580903016 0.000690306154175996 24992592;24249161 Luciferase assay was performed to verify a putative target site of miR-23a in the 3'-UTR of apoptosis protease activating factor 1 APAF1 mRNA; The expression levels of miR-23a and APAF1 in CRC cell lines SW480 and SW620 and clinical samples were assessed using reverse transcription-quantitative real-time PCR RT-qPCR and Western blot; Moreover miR-23a up-regulation was coupled with APAF1 down-regulation in CRC tissue samples;We found that the expression of miR-23a was increased and the level of apoptosis-activating factor-1 APAF-1 was decreased in 5-FU-treated colon cancer cells compared to untreated cells; APAF-1 as a target gene of miR-23a was identified and miR-23a antisense-induced increase in the activation of caspase-9 was observed ; colorectal cancer;colorectal cancer hsa-miR-23b-3p APAF1 -0.070273068040148 0.620585267977425 0.0527330819081095 0.628296064246439 miRNATAP -0.109314526987903 0.00215543348816896 NA NA NA hsa-miR-27a-3p APAF1 0.433402568013802 0.00737164631768323 0.0527330819081095 0.628296064246439 miRNATAP -0.16468480576707 8.19227183327682e-08 NA NA NA hsa-miR-27b-3p APAF1 0.236438984240408 0.12263510345883 0.0527330819081095 0.628296064246439 miRNATAP -0.166392707369462 3.36486831782177e-07 NA NA NA hsa-miR-664a-3p APAF1 0.443077463053857 0.0214248925850984 0.0527330819081095 0.628296064246439 mirMAP -0.111814656754016 1.51855061714124e-05 NA NA NA hsa-miR-26a-5p ARL6IP6 -0.126411409001078 0.440028840408711 0.137398743924794 0.360453921695339 miRNATAP -0.190938485543918 6.35760394215147e-06 NA NA NA hsa-miR-26a-5p ATAD2 -0.126411409001078 0.440028840408711 1.58072414872602 1.32398935308252e-11 MirTarget -0.405009482936048 1.40965651167476e-09 NA NA NA hsa-miR-26a-5p ATAD2B -0.126411409001078 0.440028840408711 0.614158967546123 3.75199871605925e-07 MirTarget;miRNATAP -0.10529706341534 0.00236498430296846 NA NA NA hsa-miR-26a-5p AURKAIP1 -0.126411409001078 0.440028840408711 0.626086994795953 4.0224518469533e-05 miRNAWalker2_validate -0.162213789289755 0.000188790125941259 NA NA NA hsa-miR-26a-5p AVL9 -0.126411409001078 0.440028840408711 0.938497561012414 5.82058595143881e-09 mirMAP -0.212236118444481 4.32907951186505e-06 NA NA NA hsa-miR-26a-5p B3GNT5 -0.126411409001078 0.440028840408711 -0.325981838743923 0.143739702510876 MirTarget -0.235369383744595 0.000192958067980489 NA NA NA hsa-miR-26a-5p BARD1 -0.126411409001078 0.440028840408711 0.839638040780384 0.000347649752269475 MirTarget -0.251351458544639 0.00016979163199991 NA NA NA hsa-miR-15a-5p BCL2 1.62575353599172 1.55312121019827e-19 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.187458177651156 0.00400964703367561 26915294;25594541;18931683;25623762;22335947 As a result transcript levels of the tumor-suppressive miR-15 and let-7 families increased which targeted and decreased the expression of the crucial prosurvival genes BCL-2 and BCL-XL respectively;MicroRNAs miRNAs encoded by the miR-15 cluster are known to induce G1 arrest and apoptosis by targeting G1 checkpoints and the anti-apoptotic B cell lymphoma 2 BCL-2 gene;MicroRNAs miRNAs are noncoding small RNAs that repress protein translation by targeting specific messenger RNAs miR-15a and miR-16-1 act as putative tumor suppressors by targeting the oncogene BCL2;miR 15a and miR 16 modulate drug resistance by targeting bcl 2 in human colon cancer cells; To investigate the reversal effect of targeted modulation of bcl-2 expression by miR-15a and miR-16 on drug resistance of human colon cancer cells;The expression of MiR-15a was significantly inhibited by Bcl-2 P < 0.05 poor survival;;;drug resistance; lung cancer;breast cancer;prostate cancer;colon cancer;breast cancer hsa-miR-17-5p BCL2 2.07078488653279 2.77403038572568e-19 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.116338876463301 0.0217440105866914 25435430 Combined overexpression of miR-16 and miR-17 greatly reduced Beclin-1 and Bcl-2 expressions respectively; miR-17 overexpression reduced cytoprotective autophagy by targeting Beclin-1 whereas overexpression of miR-16 potentiated paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2 lung cancer hsa-miR-200c-3p BCL2 0.380533388300368 0.0842181838538353 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase;mirMAP -0.126651991360998 0.022049998757799 NA NA NA hsa-miR-20a-3p BCL2 2.51803599558247 4.92479325298629e-13 -0.487496069869486 0.0642113742980754 mirMAP -0.102394535742893 0.0197408442233094 NA NA NA hsa-miR-20a-5p BCL2 2.64649625616975 5.1469418982085e-27 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.115004935478343 0.0136833763472092 NA NA NA hsa-miR-21-5p BCL2 4.38165933891779 1.52536633902505e-92 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.204010104736014 8.81514964878011e-06 22964582;21468550;25994220;25381586;26555418;23359184;21376256 Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells ;;;;;;drug resistance lung cancer;bladder cancer;colorectal cancer;sarcoma;breast cancer;pancreatic cancer;pancreatic cancer hsa-miR-224-5p BCL2 1.9183903633152 3.22216766330296e-06 -0.487496069869486 0.0642113742980754 mirMAP -0.138108415745186 1.72321765526623e-06 24796455 In addition the expressions of Bcl2 mRNA and protein were 1.05 ± 0.04 and 0.21 ± 0.03 in the miR-224 ASO group significantly lower than that in the control group 4.87 ± 0.96 and 0.88 ± 0.09 P < 0.01 gastric cancer hsa-miR-24-2-5p BCL2 1.43704663046967 4.34375016509278e-11 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.15947750861285 0.00351654011349327 NA NA NA hsa-miR-29a-5p BCL2 1.89519956688438 1.03453349363915e-11 -0.487496069869486 0.0642113742980754 mirMAP -0.237477310346695 2.67918561276733e-06 20041405 Subsequent investigation characterized two antiapoptotic molecules Bcl-2 and Mcl-1 as direct targets of miR-29; Furthermore silencing of Bcl-2 and Mcl-1 phenocopied the proapoptotic effect of miR-29 whereas overexpression of these proteins attenuated the effect of miR-29 liver cancer hsa-miR-3065-5p BCL2 0.653308707552535 0.0999497219778851 -0.487496069869486 0.0642113742980754 mirMAP -0.121892398301854 0.000231812969788831 NA NA NA hsa-miR-34a-5p BCL2 1.40588612517769 8.60097477768592e-12 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.185078875528925 0.00135283473559727 22964582;24565525;23155233;24444609;20687223;22623155;24988056;18803879;19714243;25053345;20433755;21399894;23862748 Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression ;drug resistance;;poor survival;drug resistance;;;poor survival;differentiation;poor survival;drug resistance;;; lung cancer;breast cancer;glioblastoma;lung squamous cell cancer;prostate cancer;breast cancer;gastric cancer;gastric cancer;pancreatic cancer;prostate cancer;colon cancer;breast cancer;liver cancer hsa-miR-365a-3p BCL2 0.0132777124336201 0.953597412537431 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;miRTarBase -0.135798592942671 0.0110668436109814 NA NA NA hsa-miR-450b-5p BCL2 1.69248953402469 1.96052058003353e-07 -0.487496069869486 0.0642113742980754 mirMAP -0.19720389328785 1.37276161625093e-06 NA NA NA hsa-miR-452-5p BCL2 0.637123950346362 0.0458173998136196 -0.487496069869486 0.0642113742980754 mirMAP -0.123489150343591 0.00113373620964249 NA NA NA hsa-miR-542-3p BCL2 1.62226640768239 2.6427102465476e-10 -0.487496069869486 0.0642113742980754 mirMAP -0.191093289471344 3.49857445479472e-05 NA NA NA hsa-miR-590-3p BCL2 0.83851360565783 0.00129224433453587 -0.487496069869486 0.0642113742980754 miRanda;mirMAP -0.123434669030393 0.0270457405646397 NA NA NA hsa-miR-590-5p BCL2 2.07441240363458 4.95240551694843e-14 -0.487496069869486 0.0642113742980754 miRanda -0.183833993408744 0.000541716198465799 NA NA NA hsa-miR-96-5p BCL2 3.0381097138467 4.40362891630201e-24 -0.487496069869486 0.0642113742980754 miRNAWalker2_validate;TargetScan -0.137358301513432 0.0019288325262615 NA NA NA hsa-miR-500a-5p BIRC2 0.648155655714409 0.0104657432932038 -0.0566424270372563 0.620255875001944 MirTarget -0.112472951411246 8.53911662639019e-08 NA NA NA hsa-miR-24-1-5p BIRC3 0.856025727237819 0.000107354490323658 0.125427105924507 0.676483616271283 MirTarget -0.206759039423342 0.0016525543606198 NA NA NA hsa-miR-375 BIRC3 0.615547997686534 0.149199273675144 0.125427105924507 0.676483616271283 miRNAWalker2_validate -0.195933533083944 7.50694584162728e-10 23726271 Taken together these data suggest that miR-375 sensitizes TNF-α-induced apoptosis and the reduction in the expression of the apoptosis inhibitory proteins cFLIP-L and cIAP2 plays an important role in this sensitization head and neck cancer hsa-miR-664a-3p BIRC3 0.443077463053857 0.0214248925850984 0.125427105924507 0.676483616271283 mirMAP -0.16585436385996 0.0215980202864507 NA NA NA hsa-miR-98-5p BIRC3 1.170602085804 1.09900501665229e-08 0.125427105924507 0.676483616271283 miRNAWalker2_validate -0.135956769299651 0.0476049079151008 NA NA NA hsa-miR-26a-5p BRWD3 -0.126411409001078 0.440028840408711 0.679124124672604 0.000349066320112974 mirMAP -0.149507199408395 0.00584190537993819 NA NA NA hsa-miR-26a-5p C16orf87 -0.126411409001078 0.440028840408711 0.573199140734654 6.84303436430621e-06 mirMAP -0.117406653170428 0.00125689321445631 NA NA NA hsa-miR-26a-5p C20orf24 -0.126411409001078 0.440028840408711 1.14265959396339 2.64828141842954e-10 miRNATAP -0.217323050480656 3.04526676046712e-05 NA NA NA hsa-miR-107 CAPN2 0.658676029898313 5.11480446318819e-07 -0.307487246393565 0.0517639236874996 miRanda -0.129487592988861 0.020246847954034 NA NA NA hsa-miR-16-2-3p CAPN2 0.503964803530872 0.0263648405197492 -0.307487246393565 0.0517639236874996 mirMAP -0.11004591764374 0.00157478022798458 NA NA NA hsa-miR-20a-3p CAPN2 2.51803599558247 4.92479325298629e-13 -0.307487246393565 0.0517639236874996 MirTarget -0.126718135438292 1.16532550012936e-06 NA NA NA hsa-miR-320b CAPN2 0.226640952564488 0.378818692487242 -0.307487246393565 0.0517639236874996 miRanda -0.123991691232165 1.04526537750598e-05 NA NA NA hsa-miR-421 CAPN2 0.170525317701774 0.535277026680289 -0.307487246393565 0.0517639236874996 miRanda -0.157545501874524 3.03052816875822e-08 NA NA NA hsa-miR-590-5p CAPN2 2.07441240363458 4.95240551694843e-14 -0.307487246393565 0.0517639236874996 miRanda -0.160886327978009 3.58492015382408e-07 NA NA NA hsa-miR-26a-5p CARM1 -0.126411409001078 0.440028840408711 0.460820313098173 6.54223053882851e-06 miRNATAP -0.156954195976941 5.25802940590747e-08 NA NA NA hsa-miR-148b-5p CASP10 1.39335695292409 2.13220380550073e-07 -0.273124939830875 0.0980559181398398 mirMAP -0.142918818215108 1.84018593774494e-05 NA NA NA hsa-miR-19a-3p CASP10 2.11776595911517 7.07663078397156e-10 -0.273124939830875 0.0980559181398398 MirTarget;mirMAP -0.103748849625307 5.82215966866069e-05 NA NA NA hsa-miR-19b-1-5p CASP10 1.71217036351784 3.28561659177495e-12 -0.273124939830875 0.0980559181398398 mirMAP -0.180380873043991 1.8051624722446e-07 NA NA NA hsa-miR-19b-3p CASP10 2.10868505662119 5.40846613768389e-17 -0.273124939830875 0.0980559181398398 MirTarget;mirMAP -0.117954936938626 0.000117554430485811 NA NA NA hsa-miR-421 CASP10 0.170525317701774 0.535277026680289 -0.273124939830875 0.0980559181398398 mirMAP -0.173186299099511 5.10535452071279e-09 NA NA NA hsa-miR-744-3p CASP10 2.07439104592565 3.30645434602132e-12 -0.273124939830875 0.0980559181398398 mirMAP -0.132075541742933 7.93996713929531e-08 NA NA NA hsa-miR-139-5p CASP3 -2.26625553116965 7.22375119369519e-16 0.749868979708077 8.30799302647668e-11 miRanda -0.103400450602475 1.92824413318983e-08 NA NA NA hsa-miR-195-3p CASP3 -1.33068822339418 6.65427393047357e-09 0.749868979708077 8.30799302647668e-11 MirTarget -0.12156615230384 1.38560895801409e-07 NA NA NA hsa-miR-30c-5p CASP3 -0.327319105755825 0.123595832152687 0.749868979708077 8.30799302647668e-11 miRNATAP -0.14954468041522 2.8553699558622e-09 NA NA NA hsa-miR-30d-5p CASP3 -0.920901858717441 3.50898334321668e-05 0.749868979708077 8.30799302647668e-11 miRNAWalker2_validate;miRTarBase;miRNATAP -0.173377620122409 2.06657661969359e-13 NA NA NA hsa-miR-125a-5p CASP6 -1.04824536696301 3.97386082850476e-07 0.904444256335095 7.02954024495495e-11 miRanda -0.117486960142462 0.000160301516487637 NA NA NA hsa-miR-664a-3p CASP7 0.443077463053857 0.0214248925850984 -0.211288307918442 0.0813860667885838 MirTarget -0.108240210919283 0.000181784451993205 NA NA NA hsa-miR-26a-5p CCDC43 -0.126411409001078 0.440028840408711 0.574691771320647 1.46567228734746e-07 miRNAWalker2_validate -0.13405891053989 1.70324503065133e-05 NA NA NA hsa-miR-26a-5p CCNE1 -0.126411409001078 0.440028840408711 2.99717740665025 1.61069658019784e-19 miRNAWalker2_validate;miRTarBase;miRNATAP -0.695101497950461 4.5037170303388e-13 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen breast cancer hsa-miR-26a-5p CCNE2 -0.126411409001078 0.440028840408711 2.14869777933212 3.82193505863706e-13 miRNAWalker2_validate;miRTarBase;miRNATAP -0.509665959363437 2.11729025570925e-09 24116110;21901171 The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression poor survival;progression pancreatic cancer;acute myeloid leukemia hsa-miR-26a-5p CCNJ -0.126411409001078 0.440028840408711 0.51073520104177 0.000360239843570767 miRNATAP -0.117571525298324 0.00396506269298705 NA NA NA hsa-miR-26a-5p CDC6 -0.126411409001078 0.440028840408711 3.07280830186032 2.61005341863179e-21 miRNAWalker2_validate -0.731323800617234 6.56506901225912e-15 25100863;27158389 Here it is demonstrated that miR26a and miR26b inhibit replication licensing and the proliferation migration and invasion of lung cancer cells by targeting CDC6; The current study suggests that miR26a miR26b and CDC6 and factors regulating their expression represent potential cancer diagnostic and prognostic markers as well as anticancer targets;miR 26a inhibits the proliferation of ovarian cancer cells via regulating CDC6 expression; Bioinformatics analysis revealed Cdc6 was a target gene of miR-26a; dual-luciferase assay and validation assay showed miR-26a could act on the 3'UTR of Cdc6 to regulate Cdc6 expression; These findings suggest that miR-26a may act on the 3'UTR of Cdc6 to regulate Cdc6 expression which then inhibit the proliferation of ovarian cancer cells and induce their apoptosis ; lung cancer;ovarian cancer hsa-miR-26a-5p CDH2 -0.126411409001078 0.440028840408711 0.208460444138559 0.682352061982617 miRNATAP -0.494609072495664 0.000614175362243147 NA NA NA hsa-miR-26a-5p CDK2AP1 -0.126411409001078 0.440028840408711 0.323823706547641 0.0136596194572327 MirTarget;miRNATAP -0.114716183461438 0.00207459362016803 NA NA NA hsa-miR-26a-5p CDK8 -0.126411409001078 0.440028840408711 0.300242294414736 0.0307119827502737 miRNAWalker2_validate -0.231492309931046 2.58371874983049e-09 NA NA NA hsa-miR-26a-5p CDR2L -0.126411409001078 0.440028840408711 0.25998843402788 0.217682696244846 miRNATAP -0.236775486116786 7.16625844686654e-05 NA NA NA hsa-miR-26a-5p CEBPG -0.126411409001078 0.440028840408711 0.0517536919914541 0.715693313043818 miRNATAP -0.1069950131803 0.00786869120052156 NA NA NA hsa-miR-26a-5p CENPP -0.126411409001078 0.440028840408711 0.513704105103643 0.00812754799461501 mirMAP -0.201012559355155 0.000263754266262076 NA NA NA hsa-miR-107 CFLAR 0.658676029898313 5.11480446318819e-07 -0.60264981549415 0.000146924534874046 miRanda -0.150916593963368 0.00732127376323208 NA NA NA hsa-miR-130b-3p CFLAR 1.83046548750752 5.04753914574694e-13 -0.60264981549415 0.000146924534874046 mirMAP -0.170030964912425 7.49012425842225e-09 NA NA NA hsa-miR-186-5p CFLAR 0.852175445703945 6.88885738584309e-10 -0.60264981549415 0.000146924534874046 mirMAP -0.109533084884528 0.0388776272198057 NA NA NA hsa-miR-320b CFLAR 0.226640952564488 0.378818692487242 -0.60264981549415 0.000146924534874046 miRanda -0.151195453642841 8.91238898066211e-08 NA NA NA hsa-miR-330-5p CFLAR 0.168520831101569 0.336433937906706 -0.60264981549415 0.000146924534874046 miRanda -0.105748491906056 0.0123982677165611 NA NA NA hsa-miR-421 CFLAR 0.170525317701774 0.535277026680289 -0.60264981549415 0.000146924534874046 miRanda -0.108323835564755 0.000185502533497704 NA NA NA hsa-miR-454-3p CFLAR 1.49453641052169 4.46235742871434e-09 -0.60264981549415 0.000146924534874046 mirMAP -0.110766292193923 0.00110247176076177 NA NA NA hsa-miR-708-5p CFLAR 3.04047795672813 3.01085192850869e-20 -0.60264981549415 0.000146924534874046 mirMAP -0.102498067556773 1.52497290863615e-05 NA NA NA hsa-miR-26a-5p CHAC1 -0.126411409001078 0.440028840408711 0.96062388185063 0.00030561379790455 MirTarget;miRNATAP -0.226033326484843 0.00294240965000026 NA NA NA hsa-miR-26a-5p CHORDC1 -0.126411409001078 0.440028840408711 0.883294935601413 9.52590828255541e-09 MirTarget -0.251280082611059 9.5758771687487e-09 NA NA NA hsa-miR-106b-5p CHP2 1.47447672652218 1.32004094930462e-13 -0.698246795377642 0.27546655425478 MirTarget -0.289307563984085 0.046059718658527 NA NA NA hsa-miR-582-5p CHP2 1.08286181406653 0.00149040450161757 -0.698246795377642 0.27546655425478 miRNATAP -0.174545230260245 0.0486087191670937 NA NA NA hsa-miR-15a-5p CHUK 1.62575353599172 1.55312121019827e-19 0.0377297766878195 0.74424413982199 miRNAWalker2_validate;miRTarBase;MirTarget -0.156480048093973 2.55421092282135e-08 NA NA NA hsa-miR-29b-2-5p CHUK 0.345881055247341 0.194842633194187 0.0377297766878195 0.74424413982199 MirTarget -0.119533869512923 1.02102108327589e-09 NA NA NA hsa-miR-339-5p CHUK 0.536997313601114 0.0488090394176611 0.0377297766878195 0.74424413982199 miRanda -0.101676919866514 1.24374098863621e-07 NA NA NA hsa-miR-342-3p CHUK -0.128691966564961 0.561034080130801 0.0377297766878195 0.74424413982199 miRanda -0.176769532720248 4.41422217910121e-14 NA NA NA hsa-miR-497-5p CHUK -0.0546347378264729 0.786205564901684 0.0377297766878195 0.74424413982199 MirTarget -0.194599570543196 4.42801403790986e-14 NA NA NA hsa-miR-26a-5p CLTC -0.126411409001078 0.440028840408711 0.437713347422649 8.69514117497297e-05 miRNATAP -0.12528537755853 7.54422056865606e-05 NA NA NA hsa-miR-26a-5p CNTD2 -0.126411409001078 0.440028840408711 3.51171210672883 6.8388880918194e-12 miRNAWalker2_validate -0.461999866352578 0.00191935232302858 NA NA NA hsa-miR-26a-5p COASY -0.126411409001078 0.440028840408711 0.763543836125371 1.40630384756548e-12 miRNAWalker2_validate -0.210321679189172 6.61165786086202e-12 NA NA NA hsa-miR-26a-5p COL11A1 -0.126411409001078 0.440028840408711 5.23228286350859 2.85537482242574e-12 miRNATAP -0.978362423046049 6.48079472118884e-06 NA NA NA hsa-miR-26a-5p COL12A1 -0.126411409001078 0.440028840408711 -0.849027180514303 0.034965601861609 miRNATAP -0.354982549299829 0.00193539103088857 NA NA NA hsa-miR-26a-5p COL1A2 -0.126411409001078 0.440028840408711 0.876118168211992 0.00368711342738012 MirTarget;miRNATAP -0.253542314755959 0.00320050316582886 NA NA NA hsa-miR-26a-5p COL5A1 -0.126411409001078 0.440028840408711 1.56547504280567 2.15706253605725e-07 miRNATAP -0.287347840568329 0.000932321553623759 NA NA NA hsa-miR-26a-5p COPS7B -0.126411409001078 0.440028840408711 0.707011523635339 9.81691463940276e-13 miRNATAP -0.169195099399196 2.31165603311389e-09 NA NA NA hsa-miR-26a-5p CPD -0.126411409001078 0.440028840408711 0.911876479581357 9.08443596366211e-05 MirTarget;mirMAP -0.227259326048398 0.000634915073665941 NA NA NA hsa-miR-15b-3p CSF2RB 0.804736041893915 0.000400279611457186 -1.28440879414381 5.98600010060944e-07 mirMAP -0.146763154921606 0.00821763442889796 NA NA NA hsa-miR-181d-5p CSF2RB 1.19058140522592 8.5908558852417e-09 -1.28440879414381 5.98600010060944e-07 MirTarget -0.225138318949885 7.93227254228292e-05 NA NA NA hsa-miR-19a-3p CSF2RB 2.11776595911517 7.07663078397156e-10 -1.28440879414381 5.98600010060944e-07 MirTarget -0.167733606420829 3.84098493798594e-05 NA NA NA hsa-miR-19b-3p CSF2RB 2.10868505662119 5.40846613768389e-17 -1.28440879414381 5.98600010060944e-07 MirTarget -0.250069990582844 1.95558645843003e-07 NA NA NA hsa-miR-139-5p CYCS -2.26625553116965 7.22375119369519e-16 0.533584069273294 0.000797541450763797 miRanda -0.177347725394177 7.68044998537411e-13 NA NA NA hsa-miR-342-3p CYCS -0.128691966564961 0.561034080130801 0.533584069273294 0.000797541450763797 mirMAP -0.104452481938135 0.00171342515724575 NA NA NA hsa-miR-26a-5p DCUN1D1 -0.126411409001078 0.440028840408711 0.144235891193565 0.301323427210419 mirMAP -0.109425023680304 0.00564960539582928 NA NA NA hsa-miR-26a-5p DEPDC1 -0.126411409001078 0.440028840408711 3.4453193569446 8.88810549846053e-21 MirTarget -0.719975750834529 2.07228860869089e-11 NA NA NA hsa-miR-26a-5p DEPDC1B -0.126411409001078 0.440028840408711 3.46407492638038 1.28193624486327e-22 MirTarget;miRNATAP -0.608347054819373 5.33025085458248e-09 NA NA NA hsa-miR-342-3p DFFA -0.128691966564961 0.561034080130801 0.208253468929684 0.0467186752814201 mirMAP -0.115285301351606 8.73927415674084e-08 NA NA NA hsa-miR-664a-3p DFFA 0.443077463053857 0.0214248925850984 0.208253468929684 0.0467186752814201 mirMAP -0.110989880099499 8.08861826721901e-06 NA NA NA hsa-miR-365a-3p DFFB 0.0132777124336201 0.953597412537431 0.546892122693686 1.60242947893897e-05 MirTarget -0.120376568746021 2.66199233996373e-06 NA NA NA hsa-miR-26a-5p DGCR14 -0.126411409001078 0.440028840408711 0.169538861688061 0.145952859916462 mirMAP;miRNATAP -0.133897891061098 4.58367535459861e-05 NA NA NA hsa-miR-26a-5p DHX15 -0.126411409001078 0.440028840408711 0.34892171542846 0.000469017671369664 miRNAWalker2_validate -0.105633702891802 0.000184182632907127 NA NA NA hsa-miR-26a-5p DLG5 -0.126411409001078 0.440028840408711 1.13470194530037 1.25261259893009e-11 MirTarget;miRNATAP -0.25506947953992 1.16138179012671e-07 NA NA NA hsa-miR-26a-5p DNAJC10 -0.126411409001078 0.440028840408711 0.796767822766086 8.14292717637844e-08 mirMAP -0.114331872525138 0.00747754538469392 NA NA NA hsa-miR-26a-5p DNMT1 -0.126411409001078 0.440028840408711 0.717163442274989 1.44212780835058e-06 miRNAWalker2_validate -0.267777758129292 1.71989249624568e-10 NA NA NA hsa-miR-26a-5p E2F2 -0.126411409001078 0.440028840408711 2.22473169258522 4.76223979917143e-17 miRNATAP -0.50169847179153 5.96567290285655e-11 26458859 MiR 26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2; Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2 and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC gastric cancer hsa-miR-26a-5p E2F7 -0.126411409001078 0.440028840408711 2.39526374034582 5.46012949053379e-12 miRNAWalker2_validate;miRNATAP -0.461308832910507 4.40880272403452e-06 23096114 Here we identify E2F7 as a novel target of miR-26a; Thus these findings indicate that the newly identified miR-26a target E2F7 might have an important role in monocytic differentiation and leukemogenesis differentiation acute myeloid leukemia hsa-miR-26a-5p EIF2AK2 -0.126411409001078 0.440028840408711 0.620787530289015 8.73480825216513e-05 mirMAP -0.140620319244894 0.00184853127994259 NA NA NA hsa-miR-26a-5p ELOVL6 -0.126411409001078 0.440028840408711 0.819759240003576 0.0278715609826653 miRNAWalker2_validate -0.261238676406014 0.0139338346770514 NA NA NA hsa-miR-130a-3p ENDOD1 0.881660100597014 0.000158893668519248 0.0574724229589449 0.802287884473109 MirTarget -0.158689380972218 0.00041229224437697 NA NA NA hsa-miR-130b-3p ENDOD1 1.83046548750752 5.04753914574694e-13 0.0574724229589449 0.802287884473109 MirTarget -0.210698970673308 6.99903178813071e-07 NA NA NA hsa-miR-16-1-3p ENDOD1 1.50034693398929 6.63958242991125e-10 0.0574724229589449 0.802287884473109 mirMAP -0.115978052272091 0.0292641693507515 NA NA NA hsa-miR-181d-5p ENDOD1 1.19058140522592 8.5908558852417e-09 0.0574724229589449 0.802287884473109 MirTarget -0.12246584317684 0.0152429489204304 NA NA NA hsa-miR-193a-3p ENDOD1 0.549173467360291 0.0319030569365466 0.0574724229589449 0.802287884473109 miRanda -0.179134327621172 5.86428802529883e-05 NA NA NA hsa-miR-193b-3p ENDOD1 1.10444771306846 0.000822888533401377 0.0574724229589449 0.802287884473109 miRNAWalker2_validate -0.193643641182539 6.00652244423002e-10 NA NA NA hsa-miR-19a-3p ENDOD1 2.11776595911517 7.07663078397156e-10 0.0574724229589449 0.802287884473109 mirMAP -0.235527854014124 2.65333290963475e-11 NA NA NA hsa-miR-19b-3p ENDOD1 2.10868505662119 5.40846613768389e-17 0.0574724229589449 0.802287884473109 mirMAP -0.214871885885688 3.84099142028988e-07 NA NA NA hsa-miR-20a-3p ENDOD1 2.51803599558247 4.92479325298629e-13 0.0574724229589449 0.802287884473109 MirTarget -0.258852413152086 4.13602159312108e-12 NA NA NA hsa-miR-26b-3p ENDOD1 1.37388760789373 8.32526977075803e-09 0.0574724229589449 0.802287884473109 mirMAP -0.162737534659261 0.000183085338364621 NA NA NA hsa-miR-301a-3p ENDOD1 2.70198002906399 1.56420889710984e-14 0.0574724229589449 0.802287884473109 MirTarget -0.118583472939953 0.00100830851237753 NA NA NA hsa-miR-330-5p ENDOD1 0.168520831101569 0.336433937906706 0.0574724229589449 0.802287884473109 miRanda -0.177326193881245 0.00347844815306811 NA NA NA hsa-miR-335-3p ENDOD1 1.51116383169018 6.88553098788624e-13 0.0574724229589449 0.802287884473109 MirTarget -0.1214967075304 0.0133545590055334 NA NA NA hsa-miR-454-3p ENDOD1 1.49453641052169 4.46235742871434e-09 0.0574724229589449 0.802287884473109 MirTarget -0.200136555991206 3.83646380056291e-05 NA NA NA hsa-miR-590-3p ENDOD1 0.83851360565783 0.00129224433453587 0.0574724229589449 0.802287884473109 miRanda -0.138507749964506 0.00426365654870339 NA NA NA hsa-miR-26a-5p EP400 -0.126411409001078 0.440028840408711 0.145076802720138 0.272088257372572 MirTarget;miRNATAP -0.111253863931129 0.0029272318628394 NA NA NA hsa-miR-24-3p EXOG -0.0357874587555003 0.785865078836504 -0.186000325296265 0.0840226962857193 MirTarget -0.104890843185061 0.00597723200942725 NA NA NA hsa-miR-26a-5p EZH2 -0.126411409001078 0.440028840408711 2.63566539246403 3.78349576722754e-27 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.552405796444427 1.30452959392404e-14 20952513;23750239;25611389;24452597;26733151;21901171;25494962;27517917;22086681;27562865;22930729;22094936 Pathologically decreased miR 26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer; Subsequently MTDH and EZH2 are identified as two direct targets of miR-26a and they are significantly upregulated in breast cancer; MCF7 xenografts with exogenous miR-26a show that a decrease in expression of both MTDH and EZH2 is accompanied by an increase in apoptosis; Our findings suggest that miR-26a functionally antagonizes human breast carcinogenesis by targeting MTDH and EZH2;MiR-26a has been reported as a tumor suppressor microRNA in breast cancer which is attributed mainly to targeting of MTDH and EZH2 however the expression profile and therapeutic potential of miR-26a is still unclear;Significant inverse correlation between EZH2 and hsa-miR-26a-5p R2=0.56 P=0.0001 and hsa-let-7b-5p R2=0.19 P=0.02 expression was observed in the same samples corroborating the belief of EZH2 being a bona fide target for these two miRNAs in CRC;Moreover EZH2 was upregulated and inversely correlated with miR-26a expression in the osteosarcoma tissues; Thus for the first time we provide convincing evidence that downregulation of miR-26a is associated with tumor aggressiveness and tumor metastasis and miR-26a inhibits cell migration and invasion by targeting the EZH2 gene in osteosarcoma;Through down-regulation of EZH2 expression and up-regulation of E-cadherin expression miR-26a inhibited the EMT process in vitro and in vivo; Luciferase reporter assay showed that miR-26a directly interacted with EZH2 messenger RNA mRNA; Furthermore the expression of miR-26a was positively correlated with E-cadherin expression and inversely correlated with EZH2 expression in human HCC tissue; miR-26a inhibited the EMT process in HCC by down-regulating EZH2 expression;Previously EZH2 was shown to be regulated by miR-26a at the translational levels in lymphomas;miR 26a promoted by interferon alpha inhibits hepatocellular carcinoma proliferation and migration by blocking EZH2; Here we report that the IFN-α-induced microRNA-26a miR-26a can inhibit HCC proliferation and invasion by suppressing enhancer of zeste homologue 2 EZH2 expression in tumor cells; It was shown that there was increased miR-26a accompanied with downregulated EZH2 expression in the HCC specimens and EZH2 mRNA levels were inversely correlated with miR-26a expression; In addition the miR-26a mimic transfection decreased the EZH2 expression level significantly in the transfected HepG2 cells and inhibited HepG2 cell proliferation and invasion effectively; Our results indicate that miR-26a exerts growth inhibition in HCC and that its inhibitory effect is mediated briefly by blocking EZH2 expression;miR-26a inhibition partly prevents the metformin viability effect and the PTEN and EZH2 expression reduction;We also found that reexpression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in pancreatic cancer cells;In the present study the influence of miR-26a and miR-138 on EZH2 and cellular function including the impact on the cell cycle regulating network was evaluated in PCa cells; The present findings suggest an anti-proliferative role for miR-26a and miR-138 in PCa by blocking the G1/S-phase transition independent of EZH2 but via a concerted inhibition of crucial cell cycle regulators;We propose the hypermethylation of miR-26a as an alternative pathway of ERG rearrangement-independent EZH2 activation;High miR 26a and low CDC2 levels associate with decreased EZH2 expression and with favorable outcome on tamoxifen in metastatic breast cancer; Main objective of the present study is to investigate miR-26a and miR-101 levels which both target EZH2 for their association with molecular pathways and with efficacy of tamoxifen as first-line monotherapy for metastatic breast cancer; Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Cell cycle regulation is the only overlapping pathway linked to miR-26a and EZH2 levels; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen tumorigenesis;;;metastasis;cell migration;;;;;;;; breast cancer;breast cancer;colorectal cancer;sarcoma;liver cancer;acute myeloid leukemia;liver cancer;breast cancer;pancreatic cancer;prostate cancer;prostate cancer;breast cancer hsa-miR-26a-5p FAM136A -0.126411409001078 0.440028840408711 1.18430145873601 1.38323839129987e-21 MirTarget;miRNATAP -0.228137139151575 3.00906805332246e-10 NA NA NA hsa-miR-26a-5p FAM199X -0.126411409001078 0.440028840408711 0.788148993932119 9.46860038929325e-09 mirMAP -0.15014392043907 0.000139881508027499 NA NA NA hsa-miR-26a-5p FAM49B -0.126411409001078 0.440028840408711 0.404948409766247 0.00295807020255253 miRNATAP -0.118686393467281 0.00217769324851333 NA NA NA hsa-miR-26a-5p FAM98A -0.126411409001078 0.440028840408711 0.629938824895667 2.44364633573002e-10 MirTarget;miRNATAP -0.161758865160172 1.11358608305011e-08 NA NA NA hsa-miR-26a-5p FANCA -0.126411409001078 0.440028840408711 2.05908519185299 3.63337130144689e-20 miRNATAP -0.443565529024891 9.27604557620594e-12 NA NA NA hsa-miR-26a-5p FANCF -0.126411409001078 0.440028840408711 0.972071870685326 1.26490707730254e-16 MirTarget -0.112193845453226 0.00110420188734872 NA NA NA hsa-miR-106a-5p FAS 1.3902608059488 6.07931522284525e-05 -0.878746828084236 0.000340153420442741 miRNAWalker2_validate;miRTarBase -0.274948885695996 7.27787651364869e-15 22431000;27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway tumorigenesis; gastric cancer;gastric cancer hsa-miR-590-5p FAS 2.07441240363458 4.95240551694843e-14 -0.878746828084236 0.000340153420442741 miRanda -0.282578087201106 9.10535063456113e-09 NA NA NA hsa-let-7e-5p FASLG -0.749418249305995 7.34668338492227e-05 0.227219484524508 0.525243087995098 miRNATAP -0.243056494896728 0.00520293662614488 NA NA NA hsa-miR-26a-5p FASN -0.126411409001078 0.440028840408711 -0.686509530936284 0.00938573479012896 miRNAWalker2_validate -0.271955023238144 0.000291875720492757 NA NA NA hsa-miR-26a-5p FBXL19 -0.126411409001078 0.440028840408711 1.33107321421435 1.14940978087523e-14 miRNATAP -0.413507569237977 2.24025135867412e-17 NA NA NA hsa-miR-26a-5p FBXO32 -0.126411409001078 0.440028840408711 1.91595142423657 1.46314381556444e-12 mirMAP -0.225339212902103 0.00428704111431432 NA NA NA hsa-miR-26a-5p FEN1 -0.126411409001078 0.440028840408711 1.39358950117114 1.13121829224272e-13 MirTarget -0.358820466989705 2.45897730549436e-11 NA NA NA hsa-miR-26a-5p FGD1 -0.126411409001078 0.440028840408711 0.40535990497792 0.08404343037993 MirTarget;miRNATAP -0.331762370178259 5.13971325423728e-07 NA NA NA hsa-miR-26a-5p FLVCR1 -0.126411409001078 0.440028840408711 1.36685243698232 5.19460627745174e-12 MirTarget;miRNATAP -0.171147420651995 0.00296252126880915 NA NA NA hsa-miR-26a-5p GDAP1 -0.126411409001078 0.440028840408711 0.104671665900572 0.63941670555552 miRNAWalker2_validate;miRTarBase -0.163969078141886 0.00974769414241604 NA NA NA hsa-miR-26a-5p GJC1 -0.126411409001078 0.440028840408711 -0.594913234242691 0.0159765868981794 mirMAP -0.16851671960439 0.0166383967354987 NA NA NA hsa-miR-26a-5p GMPS -0.126411409001078 0.440028840408711 0.624220828855719 4.24762356255573e-05 mirMAP -0.210967981478957 1.05464664176423e-06 NA NA NA hsa-miR-26a-5p GRB10 -0.126411409001078 0.440028840408711 0.160703976200381 0.476789963428872 MirTarget -0.16766365728747 0.00895381644285532 NA NA NA hsa-miR-26a-5p GTF3C2 -0.126411409001078 0.440028840408711 0.505525276593751 7.34679061990725e-08 miRNATAP -0.16895487897877 1.63676925653674e-10 NA NA NA hsa-miR-26a-5p HAPLN1 -0.126411409001078 0.440028840408711 -0.220005767993027 0.681505192142052 MirTarget;miRNATAP -0.446843929053845 0.00333109240261617 NA NA NA hsa-miR-26a-5p HIST1H4J -0.126411409001078 0.440028840408711 1.33388357394754 1.08775929211286e-06 miRNAWalker2_validate -0.293252888564174 0.000183765135433342 NA NA NA hsa-miR-26a-5p HIST2H2AA3 -0.126411409001078 0.440028840408711 1.74462251425235 3.33087016283113e-08 miRNAWalker2_validate -0.271988459861417 0.00283095413901629 NA NA NA hsa-miR-26a-5p HMGA1 -0.126411409001078 0.440028840408711 1.93147380299731 1.42272508188732e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.441449732413678 1.06432655060421e-09 25455159;25755724;23796420;22245693 Prognostic value of miR 26a and HMGA1 in urothelial bladder cancer; MicroRNA-26a miR-26a functions as a tumor suppressor by regulating its direct target gene high mobility group AT-hook 1 HMGA1; This study was aimed to investigate the associations of differential expression of miR-26a and HMGA1 with tumor progression and prognosis in urothelial bladder cancer UBC patients; One hundred and twenty-six UBC patients were selected and quantitative real-time PCR was performed to detect the expression of miR-26a and HMGA1 mRNA in the respective tumors; Our data showed the decreased expression of miR-26a and the increased expression of HMGA1 mRNA in UBC tissues compared with corresponding non-cancerous tissues both P<0.001; Then the expression levels of miR-26a in UBC tissues were negatively correlated with those of HMGA1 mRNA significantly r=-0.72 P<0.001; In addition UBC patients with combined miR-26a downregulation and HMGA1 upregulation miR-26a-low/HMGA1-high more frequently had advanced pathological stage P<0.001 and high tumor grade P<0.001; Interaction between miR-26a and its target gene HMGA1 may contribute to the malignant progression of human UBC; Tumors with miR-26a downregulation in combination with high expression of HMGA1 showed a worse prognosis than the other tumors;To investigate the crucial role of miR-26a in breast cancer and to validate whether miR-26a could regulate proliferation of breast cancer cells by targeting high mobility group AT-hook 1 HMGA1; The luciferase activity was significantly decreased after co-transfection with psiCHECK-2/HMGA1 3'-UTR and miR-26a mimics in comparison with control cells and qRT-PCR and Western blotting analysis found that HMGA1 expression at the mRNA and protein levels decreased in the miR-26a mimic-treatment group relative to NC; MTT assay showed that down regulation of HMGA1 by siRNA could significantly enhance the tumor-suppressive effect of miR-26a P < 0.05; The results of the present study indicate that miR-26a may be associated with human breast carcinogenesis which inhibits tumor cell proliferation by targeting HMGA1;miR 26a inhibits proliferation and motility in bladder cancer by targeting HMGA1; High mobility group AT-hook 1 HMGA1 a gene that modulates cell cycle transition and cell motility was verified as a novel target of miR-26a in bladder cancer;HMGA1 was proved to be a target of miR-26a by Luciferase reporter assay Real-time PCR and Western-blotting; Furthermore we demonstrated that HMGA1 an oncogene is a direct target of miR-26a; Nude mice xenograft models confirmed that metformin up-regulated the level of miR-26a and surpressed the expression of HMGA1 in vivo progression;worse prognosis;staging;malignant trasformation;tumorigenesis;motility; bladder cancer;breast cancer;bladder cancer;pancreatic cancer hsa-miR-26a-5p HMGB3 -0.126411409001078 0.440028840408711 2.90718824931638 8.20634808663043e-18 mirMAP -0.286023198484331 0.00416603037086701 NA NA NA hsa-miR-26a-5p HOXD13 -0.126411409001078 0.440028840408711 1.140701910522 0.0715293093945188 miRNATAP -0.499424525135743 0.00556528201034062 NA NA NA hsa-miR-26a-5p HS6ST1 -0.126411409001078 0.440028840408711 0.0446015172756846 0.801401031688771 miRNATAP -0.101346211991845 0.0442495684944372 NA NA NA hsa-miR-26a-5p HSPA13 -0.126411409001078 0.440028840408711 0.0660461335018709 0.67190302740316 miRNATAP -0.113665809590577 0.0101538762634408 NA NA NA hsa-miR-26a-5p HSPA8 -0.126411409001078 0.440028840408711 0.0569055608302378 0.6886867098448 miRNAWalker2_validate -0.113550039485136 0.00475859102893472 NA NA NA hsa-miR-26a-5p HUWE1 -0.126411409001078 0.440028840408711 0.2428746589499 0.0715201235034078 miRNATAP -0.105208771815253 0.00591408547185826 NA NA NA hsa-miR-107 IKBKG 0.658676029898313 5.11480446318819e-07 0.0843830838323729 0.544710841322622 miRanda -0.126711425730293 0.00969342977912645 NA NA NA hsa-miR-143-3p IKBKG -1.21021691908494 5.70938667332876e-06 0.0843830838323729 0.544710841322622 mirMAP -0.162693115202678 2.58257152475095e-12 NA NA NA hsa-miR-17-3p IKBKG 1.36706429551147 4.60388403547821e-13 0.0843830838323729 0.544710841322622 mirMAP -0.124943383525099 0.000155383572679206 NA NA NA hsa-miR-24-3p IKBKG -0.0357874587555003 0.785865078836504 0.0843830838323729 0.544710841322622 mirMAP -0.14327021053209 0.00372994900140062 NA NA NA hsa-miR-330-3p IKBKG -0.716924999893351 0.000796236278616087 0.0843830838323729 0.544710841322622 mirMAP -0.174026313241355 3.45303704238481e-09 NA NA NA hsa-miR-141-3p IL1A 3.36993755486106 5.42939251147195e-32 -2.78589291846042 1.94445738122673e-09 MirTarget -0.425166348436577 1.11437754257848e-09 NA NA NA hsa-miR-181c-5p IL1A 0.529875814537156 0.0125885822998008 -2.78589291846042 1.94445738122673e-09 MirTarget -0.41989445653036 3.99923207839548e-05 NA NA NA hsa-miR-181d-5p IL1A 1.19058140522592 8.5908558852417e-09 -2.78589291846042 1.94445738122673e-09 MirTarget -0.495373056794971 1.57350244087555e-06 NA NA NA hsa-miR-200a-3p IL1A 3.14766878548496 1.32850889777422e-21 -2.78589291846042 1.94445738122673e-09 MirTarget -0.451074234294195 9.33609082814678e-13 NA NA NA hsa-miR-30b-5p IL1A 0.358144314839612 0.138026229059594 -2.78589291846042 1.94445738122673e-09 MirTarget -0.372796563568777 3.38432266671698e-05 NA NA NA hsa-miR-30d-5p IL1A -0.920901858717441 3.50898334321668e-05 -2.78589291846042 1.94445738122673e-09 MirTarget -0.356697596588321 0.000238401377855495 NA NA NA hsa-miR-30e-5p IL1A 1.60414100786743 3.78951090573667e-19 -2.78589291846042 1.94445738122673e-09 MirTarget -0.387129646844589 0.000947181744027959 NA NA NA hsa-miR-335-5p IL1A -0.466533891325811 0.0676987038122831 -2.78589291846042 1.94445738122673e-09 miRNAWalker2_validate -0.363571202142101 0.000134067450135358 NA NA NA hsa-miR-664a-3p IL1A 0.443077463053857 0.0214248925850984 -2.78589291846042 1.94445738122673e-09 MirTarget -0.399970970989528 0.000411462536175719 NA NA NA hsa-miR-21-5p IL1B 4.38165933891779 1.52536633902505e-92 -1.4197099567083 1.3846626069017e-05 miRNAWalker2_validate;miRTarBase;MirTarget -0.134391564023665 0.0201828525145957 NA NA NA hsa-miR-30d-3p IL1B 0.00396376345349925 0.986457040013182 -1.4197099567083 1.3846626069017e-05 MirTarget -0.185546241965733 0.0112697160369794 NA NA NA hsa-miR-7-1-3p IL1B 2.61364240402652 1.98959237815786e-32 -1.4197099567083 1.3846626069017e-05 MirTarget -0.204885242824381 0.00248885388859552 NA NA NA hsa-miR-130b-5p IL1R1 1.53645187062942 1.10498816261505e-08 -0.902036062273456 1.24728661303111e-05 mirMAP -0.20947298252971 1.38476702999555e-09 NA NA NA hsa-miR-17-3p IL1R1 1.36706429551147 4.60388403547821e-13 -0.902036062273456 1.24728661303111e-05 mirMAP -0.291254110034348 2.75619676884419e-09 NA NA NA hsa-miR-186-5p IL1R1 0.852175445703945 6.88885738584309e-10 -0.902036062273456 1.24728661303111e-05 mirMAP -0.330097048462088 1.4514081890525e-06 NA NA NA hsa-miR-26b-5p IL1R1 0.72362441215247 4.7794659748036e-05 -0.902036062273456 1.24728661303111e-05 mirMAP -0.151138951739801 0.00500687907349492 NA NA NA hsa-miR-335-3p IL1R1 1.51116383169018 6.88553098788624e-13 -0.902036062273456 1.24728661303111e-05 mirMAP -0.292160492099576 2.30254080656226e-11 NA NA NA hsa-miR-361-5p IL1R1 0.21454431962475 0.0800957579368424 -0.902036062273456 1.24728661303111e-05 miRanda -0.202848902425797 0.0110414646766357 NA NA NA hsa-miR-590-3p IL1R1 0.83851360565783 0.00129224433453587 -0.902036062273456 1.24728661303111e-05 miRanda;miRNATAP -0.166712189356744 0.00014487477422078 NA NA NA hsa-miR-139-5p IL1RAP -2.26625553116965 7.22375119369519e-16 0.000245152751386257 0.999187506373076 miRanda -0.118443639544596 0.00188256138463295 NA NA NA hsa-miR-16-1-3p IL1RAP 1.50034693398929 6.63958242991125e-10 0.000245152751386257 0.999187506373076 mirMAP -0.140048006210677 0.0120173981404929 NA NA NA hsa-miR-17-5p IL1RAP 2.07078488653279 2.77403038572568e-19 0.000245152751386257 0.999187506373076 MirTarget;TargetScan -0.201324308672122 1.15234440604181e-05 NA NA NA hsa-miR-186-5p IL1RAP 0.852175445703945 6.88885738584309e-10 0.000245152751386257 0.999187506373076 mirMAP -0.220997757431585 0.00560235433690743 NA NA NA hsa-miR-19a-3p IL1RAP 2.11776595911517 7.07663078397156e-10 0.000245152751386257 0.999187506373076 MirTarget -0.204065274766844 4.68860420392829e-08 NA NA NA hsa-miR-19b-3p IL1RAP 2.10868505662119 5.40846613768389e-17 0.000245152751386257 0.999187506373076 MirTarget -0.227644553615202 2.9123960861649e-07 NA NA NA hsa-miR-204-5p IL1RAP -1.01965803752657 0.00767207541525746 0.000245152751386257 0.999187506373076 miRNAWalker2_validate -0.108955560529284 0.000176986072537337 NA NA NA hsa-miR-20a-5p IL1RAP 2.64649625616975 5.1469418982085e-27 0.000245152751386257 0.999187506373076 MirTarget -0.207167611000991 8.81529955413445e-07 NA NA NA hsa-miR-29a-3p IL1RAP 0.101650412194573 0.573201097011668 0.000245152751386257 0.999187506373076 MirTarget;miRNATAP -0.191769017989552 0.00191288163853844 NA NA NA hsa-miR-29b-3p IL1RAP 3.10527711861309 3.01242507282711e-32 0.000245152751386257 0.999187506373076 MirTarget;miRNATAP -0.204557456978232 1.41972422604361e-07 NA NA NA hsa-miR-29c-3p IL1RAP 1.32354490728858 1.84279305179762e-07 0.000245152751386257 0.999187506373076 MirTarget;miRNATAP -0.168567921542829 8.63855866890971e-05 NA NA NA hsa-miR-375 IL1RAP 0.615547997686534 0.149199273675144 0.000245152751386257 0.999187506373076 miRNAWalker2_validate;miRanda -0.142709680140902 2.39984635102537e-08 NA NA NA hsa-miR-454-3p IL1RAP 1.49453641052169 4.46235742871434e-09 0.000245152751386257 0.999187506373076 MirTarget -0.13278942771255 0.00959574339052586 NA NA NA hsa-miR-576-5p IL1RAP 1.02693643167056 1.14846964470173e-06 0.000245152751386257 0.999187506373076 mirMAP -0.150524986290784 0.00382112305947481 NA NA NA hsa-miR-582-5p IL1RAP 1.08286181406653 0.00149040450161757 0.000245152751386257 0.999187506373076 MirTarget -0.139501140069638 2.33773623468932e-05 NA NA NA hsa-miR-664a-3p IL1RAP 0.443077463053857 0.0214248925850984 0.000245152751386257 0.999187506373076 mirMAP -0.152730147384317 0.00816289760017588 NA NA NA hsa-miR-7-1-3p IL1RAP 2.61364240402652 1.98959237815786e-32 0.000245152751386257 0.999187506373076 MirTarget -0.125460645664714 0.0112093164942368 NA NA NA hsa-miR-93-5p IL1RAP 1.50844106515467 1.83836866996875e-12 0.000245152751386257 0.999187506373076 MirTarget -0.112688886804948 0.0262344005966696 NA NA NA hsa-miR-95-3p IL1RAP -0.191519075333182 0.533735544214583 0.000245152751386257 0.999187506373076 MirTarget -0.132874977071657 0.000340944679739554 NA NA NA hsa-miR-146a-5p IRAK1 0.684701497250824 0.0105316554224149 1.11249641990519 7.42189849563542e-14 miRNAWalker2_validate;miRTarBase -0.101832573808984 0.000147555897647003 25242818;22846912;21632853 Interestingly re-expression of miR-146a inhibited the invasive capacity of Colo357 and Panc-1 PC cells with concomitant down-regulation of EGFR and IRAK-1; Most importantly we found that the treatment of PC cells with "natural agents" 33'-diinodolylmethane DIM or isoflavone led to an increase in the expression of miR-146a and consequently down-regulated the expression of EGFR MTA-2 IRAK-1 and NF-κB resulting in the inhibition of invasion of Colo357 and Panc-1 cells;Functional analysis revealed that miR-146a rs2910164 C allele inhibited cell proliferation and significantly downregulated expression of IRAK1 and TRAF6 in bladder cancer cells;The regulation of EGFR and IRAK1 by miR-146a was examined with miR-146a-transfected gastric cancer cells; Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells; MiR-146a targeting of EGFR and IRAK1 is an independent prognostic factor in gastric cancer cases ;; pancreatic cancer;bladder cancer;gastric cancer hsa-miR-335-5p IRAK2 -0.466533891325811 0.0676987038122831 0.567287186290348 0.0152967123507346 miRNAWalker2_validate -0.16550007553947 0.00045872865745022 NA NA NA hsa-miR-141-3p IRAK3 3.36993755486106 5.42939251147195e-32 -1.31653047867367 9.84276567820939e-06 mirMAP -0.146294779355006 0.00115134062341314 NA NA NA hsa-miR-20a-3p IRAK3 2.51803599558247 4.92479325298629e-13 -1.31653047867367 9.84276567820939e-06 mirMAP -0.187141915295028 0.000174865553791266 NA NA NA hsa-miR-21-5p IRAK3 4.38165933891779 1.52536633902505e-92 -1.31653047867367 9.84276567820939e-06 mirMAP -0.201892704895579 0.000120101491819665 NA NA NA hsa-miR-25-3p IRAK3 0.361927330834176 0.0163670566170988 -1.31653047867367 9.84276567820939e-06 mirMAP -0.239604432744736 0.00982482842095353 NA NA NA hsa-miR-3200-3p IRAK3 0.521712783553188 0.134990592651885 -1.31653047867367 9.84276567820939e-06 mirMAP -0.147424016420393 0.000299400692988312 NA NA NA hsa-miR-324-5p IRAK3 1.06955541886548 5.39722006604758e-05 -1.31653047867367 9.84276567820939e-06 miRanda -0.138862111225755 0.00751997615275624 NA NA NA hsa-miR-335-3p IRAK3 1.51116383169018 6.88553098788624e-13 -1.31653047867367 9.84276567820939e-06 mirMAP -0.447288987971565 1.16142984363208e-12 NA NA NA hsa-miR-33a-5p IRAK3 2.80127809675219 5.09053890529424e-12 -1.31653047867367 9.84276567820939e-06 mirMAP -0.129087503700998 0.00174107996862328 NA NA NA hsa-miR-421 IRAK3 0.170525317701774 0.535277026680289 -1.31653047867367 9.84276567820939e-06 miRanda;mirMAP -0.132796225968858 0.0154793959682764 NA NA NA hsa-miR-450b-5p IRAK3 1.69248953402469 1.96052058003353e-07 -1.31653047867367 9.84276567820939e-06 mirMAP -0.176423483699516 0.000163748438267334 NA NA NA hsa-miR-501-5p IRAK3 0.411357595674671 0.10435288464149 -1.31653047867367 9.84276567820939e-06 mirMAP -0.115229192234932 0.0356103577466442 NA NA NA hsa-miR-589-3p IRAK3 1.34253876396688 1.84935927493927e-05 -1.31653047867367 9.84276567820939e-06 mirMAP -0.129315117987875 0.00422615870683415 NA NA NA hsa-miR-590-5p IRAK3 2.07441240363458 4.95240551694843e-14 -1.31653047867367 9.84276567820939e-06 mirMAP -0.230007167814281 0.000144934857159697 NA NA NA hsa-miR-660-5p IRAK3 2.04875198906126 1.08269480928897e-17 -1.31653047867367 9.84276567820939e-06 mirMAP -0.132393087948539 0.0211062757131547 NA NA NA hsa-miR-26a-5p ITGA5 -0.126411409001078 0.440028840408711 -1.01121491098415 8.84227998350758e-06 miRNATAP -0.204698760741648 0.00168812743238086 25537511 Furthermore we provide experimental evidence to confirm that ITGA5 is a bona fide target of miR-26a liver cancer hsa-miR-26a-5p ITSN1 -0.126411409001078 0.440028840408711 -0.279284867182052 0.035252782717714 mirMAP -0.103165886599219 0.00613131752939782 NA NA NA hsa-miR-26a-5p KCMF1 -0.126411409001078 0.440028840408711 0.270811481056203 0.00636064047805838 miRNATAP -0.111172601381373 7.18482522035248e-05 NA NA NA hsa-miR-26a-5p KCTD5 -0.126411409001078 0.440028840408711 0.55754924196518 3.19719885486173e-05 miRNAWalker2_validate -0.119446215353001 0.00179808612950997 NA NA NA hsa-miR-26a-5p KIAA1147 -0.126411409001078 0.440028840408711 -0.204176060599798 0.184061334514689 mirMAP -0.104564053708449 0.0165701698260284 NA NA NA hsa-miR-26a-5p KPNA1 -0.126411409001078 0.440028840408711 0.0774164708184992 0.4478025343801 mirMAP -0.116060254835345 5.15986030515885e-05 NA NA NA hsa-miR-26a-5p KPNA2 -0.126411409001078 0.440028840408711 1.69119087105328 2.91951617049277e-13 MirTarget -0.502612448017839 2.31791917806009e-14 NA NA NA hsa-miR-26a-5p LARP1 -0.126411409001078 0.440028840408711 0.422200044532952 0.00110425642523566 miRNATAP -0.145379446119467 7.37947755819252e-05 26063484 Gene expression data and in silico analysis showed that the gene encoding La-related protein 1 LARP1 was a putative candidate of miR-26a and miR-26b regulation; Moreover luciferase reporter assays revealed that LARP1 was a direct target of both miR-26a and miR-26b; Our present data suggested that loss of tumor-suppressive miR-26a and miR-26b enhanced cancer cell invasion in PCa through direct regulation of oncogenic LARP1 prostate cancer hsa-miR-26a-5p LINGO1 -0.126411409001078 0.440028840408711 1.63725568539424 5.0746214204727e-06 miRNATAP -0.212183053807923 0.0398922724633546 NA NA NA hsa-miR-26a-5p LPGAT1 -0.126411409001078 0.440028840408711 0.965572372904362 4.14640366517532e-10 mirMAP -0.112355191249808 0.0120299909910556 NA NA NA hsa-miR-26a-5p LSM12 -0.126411409001078 0.440028840408711 0.62699745664688 8.80047940200662e-09 MirTarget;miRNATAP -0.115556177038153 0.000217391358344482 NA NA NA hsa-miR-26a-5p MAEA -0.126411409001078 0.440028840408711 0.363400635651982 0.000350194508728585 MirTarget -0.118989162651096 3.49291100029036e-05 NA NA NA hsa-miR-26a-5p MAP2 -0.126411409001078 0.440028840408711 -1.20387553493088 0.000895067915840975 MirTarget;miRNATAP -0.204907283268036 0.048271677584232 NA NA NA hsa-miR-106b-5p MAP3K14 1.47447672652218 1.32004094930462e-13 -0.508395608018966 0.005388667824716 MirTarget -0.148081791172922 0.000331285249363202 NA NA NA hsa-miR-17-3p MAP3K14 1.36706429551147 4.60388403547821e-13 -0.508395608018966 0.005388667824716 MirTarget -0.160398561527579 0.000231985049439229 NA NA NA hsa-miR-26a-5p MAP7 -0.126411409001078 0.440028840408711 0.444391918230147 0.0106684371761414 MirTarget -0.130232860404149 0.00856502366893378 NA NA NA hsa-miR-26a-5p MAPK6 -0.126411409001078 0.440028840408711 0.442185686434684 0.00511509129113629 MirTarget -0.227787183836652 3.08650143966832e-07 NA NA NA hsa-miR-26a-5p MEX3B -0.126411409001078 0.440028840408711 0.957582152806022 1.38244360621664e-06 miRNATAP -0.224071281353485 7.82565099895564e-05 NA NA NA hsa-miR-26a-5p MLEC -0.126411409001078 0.440028840408711 0.378188080636328 0.0154450070180976 miRNATAP -0.123365254586633 0.00545121723902273 NA NA NA hsa-miR-26a-5p MMP14 -0.126411409001078 0.440028840408711 0.853770939661442 0.000211702855196161 miRNATAP -0.236934517399567 0.000310393452321971 NA NA NA hsa-miR-26a-5p MRPL35 -0.126411409001078 0.440028840408711 0.421583682109827 2.25597572652792e-05 mirMAP -0.108511181575509 0.000121969474701477 NA NA NA hsa-miR-26a-5p MRPL51 -0.126411409001078 0.440028840408711 0.503084200308061 9.21441777441909e-05 miRNAWalker2_validate -0.1286292090456 0.00044355828462813 NA NA NA hsa-miR-26a-5p MSH6 -0.126411409001078 0.440028840408711 0.603431222186702 1.86969367235948e-05 miRNAWalker2_validate -0.207306504698793 2.05373907355778e-07 NA NA NA hsa-miR-26a-5p MTHFD2 -0.126411409001078 0.440028840408711 1.38116504109133 3.40087940122038e-10 mirMAP -0.352260101193581 2.18186944981716e-08 NA NA NA hsa-miR-26a-5p MTX2 -0.126411409001078 0.440028840408711 0.834593671147864 3.42210589957025e-13 MirTarget;miRNATAP -0.105427772550762 0.00155210814857024 NA NA NA hsa-miR-365a-3p MYD88 0.0132777124336201 0.953597412537431 -0.587709074735129 7.43383821392277e-07 MirTarget -0.123020139940839 3.03625517446058e-07 NA NA NA hsa-miR-429 MYD88 2.3794516574089 1.72813419703734e-13 -0.587709074735129 7.43383821392277e-07 miRanda -0.113048835976415 1.68777256167566e-10 NA NA NA hsa-miR-26a-5p NAA15 -0.126411409001078 0.440028840408711 0.434835391794936 0.000489315116278007 MirTarget;miRNATAP -0.164849784496571 2.917426745487e-06 NA NA NA hsa-miR-26a-5p NACC2 -0.126411409001078 0.440028840408711 -0.766517132485546 9.86214088829339e-05 mirMAP;miRNATAP -0.131084282621346 0.0200285209746585 NA NA NA hsa-miR-26a-5p NAMPT -0.126411409001078 0.440028840408711 0.025988903642669 0.921706421025021 miRNATAP -0.21066451907414 0.00500524701318241 NA NA NA hsa-miR-26a-5p NAV1 -0.126411409001078 0.440028840408711 0.643081042817989 0.00272015580998536 mirMAP -0.172284494894785 0.00484379182207737 NA NA NA hsa-miR-671-5p NFKB1 2.24156654191798 2.10433241567652e-14 -0.340270335589995 0.00609383891055805 MirTarget -0.104865468815509 3.02257267140541e-06 NA NA NA hsa-let-7b-5p NGF -1.62016148171663 1.56547487335694e-15 0.201813000750518 0.680403675107959 MirTarget -0.242858337482323 0.0246273998823271 NA NA NA hsa-miR-320a NGF -0.961144925954715 1.62478794429204e-08 0.201813000750518 0.680403675107959 miRanda -0.306575920656902 0.0199126531419783 NA NA NA hsa-miR-320b NGF 0.226640952564488 0.378818692487242 0.201813000750518 0.680403675107959 miRanda -0.175428791274416 0.0460777091944554 NA NA NA hsa-miR-26a-5p NLK -0.126411409001078 0.440028840408711 0.200178958380761 0.0535794568700787 miRNATAP -0.110559225376151 0.000156249291102499 NA NA NA hsa-miR-26a-5p NPLOC4 -0.126411409001078 0.440028840408711 0.621972533624965 2.23854402271804e-08 mirMAP -0.185195841266854 4.16674329774429e-09 NA NA NA hsa-miR-26a-5p NT5DC3 -0.126411409001078 0.440028840408711 0.690836878870525 0.000252254955596184 mirMAP -0.239192618776333 7.99845754488593e-06 NA NA NA hsa-miR-185-3p NTRK1 -0.377490365509078 0.093653288903368 -1.20191019732804 0.000181518709629851 MirTarget -0.220344116634979 0.000867618792014595 NA NA NA hsa-miR-26a-5p NUP153 -0.126411409001078 0.440028840408711 0.0503878867933567 0.695573741426605 miRNATAP -0.122803796394895 0.000735019121787557 NA NA NA hsa-miR-26a-5p NUP155 -0.126411409001078 0.440028840408711 1.05660120881283 9.40636592440548e-08 mirMAP -0.292885797124114 2.09743529804556e-07 NA NA NA hsa-miR-26a-5p NUP205 -0.126411409001078 0.440028840408711 0.476965923583248 0.000695207062231521 miRNAWalker2_validate -0.257124723612281 6.2830961092334e-11 NA NA NA hsa-miR-26a-5p OLA1 -0.126411409001078 0.440028840408711 0.820686645642415 4.84795948840091e-10 miRNAWalker2_validate -0.140728415915223 0.000211216696429182 NA NA NA hsa-miR-26a-5p OTUD6B -0.126411409001078 0.440028840408711 0.280332778435085 0.0746340465601679 MirTarget -0.161410023036055 0.000287292405623554 NA NA NA hsa-miR-26a-5p PAWR -0.126411409001078 0.440028840408711 0.414006493998714 0.00956669483547845 MirTarget;mirMAP -0.269369718234263 1.76756333392639e-09 NA NA NA hsa-miR-26a-5p PCCB -0.126411409001078 0.440028840408711 0.266396200473873 0.021572073948102 mirMAP -0.114400583329291 0.000485810415487742 NA NA NA hsa-miR-26a-5p PCYT1A -0.126411409001078 0.440028840408711 -0.130866451561566 0.283918253910384 miRNAWalker2_validate -0.12516216746517 0.000281967102042442 NA NA NA hsa-miR-26a-5p PGM2 -0.126411409001078 0.440028840408711 -0.0494374399802551 0.774993376849384 MirTarget -0.160342484183667 0.00105592196975355 NA NA NA hsa-miR-26a-5p PGM2L1 -0.126411409001078 0.440028840408711 1.69535158857047 3.32945698097982e-15 miRNATAP -0.22356231645409 0.000381845339706827 NA NA NA hsa-miR-26a-5p PHF6 -0.126411409001078 0.440028840408711 0.641040656384869 6.11918396852708e-07 MirTarget;mirMAP;miRNATAP -0.131156748117489 0.000360276001938116 NA NA NA hsa-miR-26a-5p PHTF2 -0.126411409001078 0.440028840408711 0.568974067702746 0.000118173985993022 MirTarget;miRNATAP -0.162164020216541 0.000114532036361555 NA NA NA hsa-miR-26a-5p PI15 -0.126411409001078 0.440028840408711 0.835096398752105 0.0420187389820186 mirMAP -0.268995078506631 0.0215700380455188 NA NA NA hsa-miR-186-5p PIK3CA 0.852175445703945 6.88885738584309e-10 -0.335143841150832 0.0107695904000801 mirMAP -0.158211833933772 0.000271764939125213 NA NA NA hsa-miR-501-5p PIK3CA 0.411357595674671 0.10435288464149 -0.335143841150832 0.0107695904000801 mirMAP -0.12161859871495 2.80222388365699e-07 NA NA NA hsa-miR-96-5p PIK3CA 3.0381097138467 4.40362891630201e-24 -0.335143841150832 0.0107695904000801 TargetScan -0.126074442438012 7.26672594996813e-09 NA NA NA hsa-miR-454-3p PIK3CB 1.49453641052169 4.46235742871434e-09 0.0520424688078016 0.708498300848208 miRNATAP -0.107092855274913 0.000279808925292599 NA NA NA hsa-miR-421 PIK3CD 0.170525317701774 0.535277026680289 -0.165252183051274 0.400815192488832 miRanda -0.187035284767016 1.2803934448503e-07 NA NA NA hsa-miR-148b-3p PIK3CG 0.483970528590224 0.0026495409465901 -1.19325793461087 5.28114748039233e-05 miRNAWalker2_validate -0.239430332797948 0.00515332606189168 NA NA NA hsa-miR-26b-5p PIK3CG 0.72362441215247 4.7794659748036e-05 -1.19325793461087 5.28114748039233e-05 miRNAWalker2_validate -0.285401672500096 0.000198071700272844 NA NA NA hsa-miR-29b-3p PIK3CG 3.10527711861309 3.01242507282711e-32 -1.19325793461087 5.28114748039233e-05 miRTarBase -0.13454994451672 0.00563635188925694 NA NA NA hsa-miR-335-3p PIK3CG 1.51116383169018 6.88553098788624e-13 -1.19325793461087 5.28114748039233e-05 mirMAP -0.273824058387904 1.51960031354635e-05 NA NA NA hsa-miR-542-3p PIK3CG 1.62226640768239 2.6427102465476e-10 -1.19325793461087 5.28114748039233e-05 miRanda -0.188110029792226 0.000315799878113487 NA NA NA hsa-miR-106a-5p PIK3R1 1.3902608059488 6.07931522284525e-05 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.152594260668069 8.26964346589391e-10 NA NA NA hsa-miR-106b-5p PIK3R1 1.47447672652218 1.32004094930462e-13 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.274486784039244 3.92361901886501e-13 NA NA NA hsa-miR-107 PIK3R1 0.658676029898313 5.11480446318819e-07 -1.28526113405546 1.1596112892202e-14 MirTarget;PITA;miRanda;miRNATAP -0.134608742116129 0.0261488734968106 NA NA NA hsa-miR-128-3p PIK3R1 1.03509868349735 2.11606310588315e-10 -1.28526113405546 1.1596112892202e-14 MirTarget -0.262733562571172 2.81828198129055e-08 25962360 miR 128 3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients; Mechanistically miR-128-3p was confirmed to regulate PIK3R1 p85α expression thereby suppressing phosphatidylinositol 3-kinase PI3K/AKT pathway activation using qRT-PCR and western blot analysis; Hence we conclude that miR-128-3p which is frequently downregulated in HCC inhibits HCC progression by regulating PIK3R1 and PI3K/AKT activation and is a prognostic marker for HCC patients worse prognosis;progression liver cancer hsa-miR-1301-3p PIK3R1 0.845987603184611 0.000579808501723616 -1.28526113405546 1.1596112892202e-14 MirTarget -0.252566507630763 3.89638206850943e-16 NA NA NA hsa-miR-15a-5p PIK3R1 1.62575353599172 1.55312121019827e-19 -1.28526113405546 1.1596112892202e-14 MirTarget -0.198845640675418 2.2459439580454e-06 NA NA NA hsa-miR-16-2-3p PIK3R1 0.503964803530872 0.0263648405197492 -1.28526113405546 1.1596112892202e-14 MirTarget -0.215346374588015 7.85659740371802e-09 NA NA NA hsa-miR-16-5p PIK3R1 0.749619098384047 4.11649450706988e-06 -1.28526113405546 1.1596112892202e-14 MirTarget -0.14663084031301 0.00245632583144358 NA NA NA hsa-miR-17-5p PIK3R1 2.07078488653279 2.77403038572568e-19 -1.28526113405546 1.1596112892202e-14 MirTarget;TargetScan;miRNATAP -0.30827377198364 1.00416866782136e-22 NA NA NA hsa-miR-182-5p PIK3R1 3.21839823004635 5.13049145201115e-39 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.153577568348738 1.31399000956901e-07 NA NA NA hsa-miR-185-5p PIK3R1 1.14291034858482 2.95777119743491e-13 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.266123472564886 5.49627003455298e-08 NA NA NA hsa-miR-186-5p PIK3R1 0.852175445703945 6.88885738584309e-10 -1.28526113405546 1.1596112892202e-14 mirMAP -0.266496146428416 2.3226235073163e-06 NA NA NA hsa-miR-200c-3p PIK3R1 0.380533388300368 0.0842181838538353 -1.28526113405546 1.1596112892202e-14 mirMAP -0.174738637328334 9.22364461849854e-07 NA NA NA hsa-miR-20a-5p PIK3R1 2.64649625616975 5.1469418982085e-27 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.268255645046992 2.93530513676098e-20 NA NA NA hsa-miR-21-5p PIK3R1 4.38165933891779 1.52536633902505e-92 -1.28526113405546 1.1596112892202e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.239855941401679 1.66617444081141e-16 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-22-5p PIK3R1 1.71436244278242 9.85038001236064e-15 -1.28526113405546 1.1596112892202e-14 mirMAP -0.249170402831725 1.77307790115702e-13 NA NA NA hsa-miR-29b-3p PIK3R1 3.10527711861309 3.01242507282711e-32 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.169264704761152 8.1620915503371e-10 NA NA NA hsa-miR-335-3p PIK3R1 1.51116383169018 6.88553098788624e-13 -1.28526113405546 1.1596112892202e-14 mirMAP -0.174731000503181 1.56931158200611e-06 NA NA NA hsa-miR-424-5p PIK3R1 1.26485330287919 6.1498991028257e-06 -1.28526113405546 1.1596112892202e-14 MirTarget -0.120660860108298 1.41199550729587e-05 NA NA NA hsa-miR-450b-5p PIK3R1 1.69248953402469 1.96052058003353e-07 -1.28526113405546 1.1596112892202e-14 miRNATAP -0.105483872062601 7.60035078150308e-05 NA NA NA hsa-miR-582-5p PIK3R1 1.08286181406653 0.00149040450161757 -1.28526113405546 1.1596112892202e-14 mirMAP -0.121659359408152 1.98808465862233e-07 NA NA NA hsa-miR-589-3p PIK3R1 1.34253876396688 1.84935927493927e-05 -1.28526113405546 1.1596112892202e-14 mirMAP -0.110115880585781 1.73041185531321e-05 NA NA NA hsa-miR-590-3p PIK3R1 0.83851360565783 0.00129224433453587 -1.28526113405546 1.1596112892202e-14 miRanda;mirMAP -0.21433969556349 1.93094554722457e-09 NA NA NA hsa-miR-590-5p PIK3R1 2.07441240363458 4.95240551694843e-14 -1.28526113405546 1.1596112892202e-14 MirTarget;PITA;miRanda;miRNATAP -0.297606057222883 4.39734655384069e-19 NA NA NA hsa-miR-629-3p PIK3R1 1.31892116211001 0.000114487182853678 -1.28526113405546 1.1596112892202e-14 MirTarget -0.155200085033098 2.2200629415611e-10 NA NA NA hsa-miR-93-5p PIK3R1 1.50844106515467 1.83836866996875e-12 -1.28526113405546 1.1596112892202e-14 MirTarget;miRNATAP -0.302548872464343 3.62432128460294e-18 NA NA NA hsa-miR-96-5p PIK3R1 3.0381097138467 4.40362891630201e-24 -1.28526113405546 1.1596112892202e-14 TargetScan;miRNATAP -0.247820034174453 4.28366535969023e-19 NA NA NA hsa-miR-29b-1-5p PIK3R3 1.71024742617744 3.64915691793611e-09 -0.993075734580867 1.37876508579496e-06 mirMAP -0.137607471527013 2.02669327816331e-05 NA NA NA hsa-miR-335-3p PIK3R3 1.51116383169018 6.88553098788624e-13 -0.993075734580867 1.37876508579496e-06 mirMAP -0.239450639911665 5.21180596069304e-08 NA NA NA hsa-miR-107 PIK3R5 0.658676029898313 5.11480446318819e-07 -1.41857329052665 4.9150449517908e-09 miRanda -0.303365993068523 0.000471196296141979 NA NA NA hsa-miR-182-5p PIK3R5 3.21839823004635 5.13049145201115e-39 -1.41857329052665 4.9150449517908e-09 MirTarget -0.327566926397612 1.58877421029473e-15 NA NA NA hsa-miR-26a-5p PITPNC1 -0.126411409001078 0.440028840408711 0.360691200119788 0.149452726061611 MirTarget;miRNATAP -0.260651942357379 0.000235829470817179 NA NA NA hsa-miR-26a-5p PLEKHH1 -0.126411409001078 0.440028840408711 0.346459699737567 0.361292700670392 miRNATAP -0.239325122077229 0.0266896270985941 NA NA NA hsa-miR-26a-5p PLOD2 -0.126411409001078 0.440028840408711 1.27626900643861 6.592887294488e-05 MirTarget;miRNATAP -0.468339724882361 2.40086489698333e-07 26983694;27310702 Thus our data showed that two genes promoting metastasis LOXL2 and PLOD2 were epigenetically regulated by tumor-suppressive microRNAs miR-26a and miR-26b providing important insights into the molecular mechanisms of RCC metastasis;The gene encoding procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 PLOD2 a collagen crosslinking enzyme was directly regulated by miR-26a-5p and miR-26b-5p; PLOD2 which is associated with the stiffness of the extracellular matrix was directly regulated by miR-26a-5p and miR-26b-5p and may be a good prognostic marker in patients with BC metastasis; kidney renal cell cancer;bladder cancer hsa-miR-26a-5p POLR3G -0.126411409001078 0.440028840408711 0.675838969394989 0.00520811911898698 MirTarget -0.346579081022979 3.86358707943556e-07 NA NA NA hsa-miR-26a-5p POM121 -0.126411409001078 0.440028840408711 0.177261527843018 0.109545284975034 mirMAP -0.118767623169282 0.000143296550740942 NA NA NA hsa-miR-26a-5p PPIA -0.126411409001078 0.440028840408711 0.446598636191056 0.000591389275206593 miRNAWalker2_validate -0.119640307127027 0.00121184299515135 NA NA NA hsa-miR-26a-5p PPP1CC -0.126411409001078 0.440028840408711 0.14862984928136 0.172735526583351 miRNAWalker2_validate -0.103235841569694 0.000794412329745643 NA NA NA hsa-miR-106a-5p PPP3CA 1.3902608059488 6.07931522284525e-05 -0.313973239016408 0.0165177462343014 miRNATAP -0.133933104567234 1.19345709173472e-12 NA NA NA hsa-miR-142-3p PPP3CA 3.98476449801341 1.56256182021111e-35 -0.313973239016408 0.0165177462343014 miRNATAP -0.118826172048727 2.75854825586705e-12 NA NA NA hsa-miR-17-5p PPP3CA 2.07078488653279 2.77403038572568e-19 -0.313973239016408 0.0165177462343014 miRNATAP -0.176015588845375 7.62312188608765e-13 NA NA NA hsa-miR-186-5p PPP3CA 0.852175445703945 6.88885738584309e-10 -0.313973239016408 0.0165177462343014 mirMAP -0.286847992743368 1.57472937315132e-11 NA NA NA hsa-miR-20a-5p PPP3CA 2.64649625616975 5.1469418982085e-27 -0.313973239016408 0.0165177462343014 miRNATAP -0.154552998486965 9.11892644521842e-12 NA NA NA hsa-miR-20b-5p PPP3CA 1.35770573270947 0.00260808530013016 -0.313973239016408 0.0165177462343014 miRNATAP -0.122294666346707 1.15249428256532e-19 NA NA NA hsa-miR-30c-5p PPP3CA -0.327319105755825 0.123595832152687 -0.313973239016408 0.0165177462343014 miRNATAP -0.10873673306536 0.000125286600086868 NA NA NA hsa-miR-361-3p PPP3CA 0.0988926195529967 0.549128728500555 -0.313973239016408 0.0165177462343014 MirTarget;PITA;miRNATAP -0.173641727258806 2.07130127414673e-06 NA NA NA hsa-miR-501-3p PPP3CA -0.0405952693028064 0.866802243505833 -0.313973239016408 0.0165177462343014 MirTarget;PITA;miRNATAP -0.152231773192009 5.82453493976863e-10 NA NA NA hsa-miR-502-3p PPP3CA -0.262270070977708 0.161760375279961 -0.313973239016408 0.0165177462343014 MirTarget;PITA;miRNATAP -0.102225645893012 0.00155670003675052 NA NA NA hsa-miR-589-3p PPP3CA 1.34253876396688 1.84935927493927e-05 -0.313973239016408 0.0165177462343014 MirTarget -0.111512777165905 9.25189699847489e-09 NA NA NA hsa-miR-590-3p PPP3CA 0.83851360565783 0.00129224433453587 -0.313973239016408 0.0165177462343014 miRanda;mirMAP -0.108711400054004 7.97592745451833e-05 NA NA NA hsa-miR-590-5p PPP3CA 2.07441240363458 4.95240551694843e-14 -0.313973239016408 0.0165177462343014 PITA;miRanda;miRNATAP -0.177690930412641 6.75602594094779e-12 NA NA NA hsa-miR-7-1-3p PPP3CA 2.61364240402652 1.98959237815786e-32 -0.313973239016408 0.0165177462343014 MirTarget;mirMAP -0.121059394653456 5.88147588879243e-06 NA NA NA hsa-miR-93-3p PPP3CA 1.07631808403007 1.63747525692813e-05 -0.313973239016408 0.0165177462343014 miRNATAP -0.170128744194282 3.50156314525736e-13 NA NA NA hsa-miR-93-5p PPP3CA 1.50844106515467 1.83836866996875e-12 -0.313973239016408 0.0165177462343014 miRNATAP -0.25180151434334 1.28858993768457e-21 NA NA NA hsa-miR-15a-5p PPP3CB 1.62575353599172 1.55312121019827e-19 -0.217161149975175 0.026537796620393 miRNATAP -0.123109224513088 2.45320870406106e-07 NA NA NA hsa-miR-30c-5p PPP3CB -0.327319105755825 0.123595832152687 -0.217161149975175 0.026537796620393 miRNATAP -0.117562918064524 1.93721091880072e-08 NA NA NA hsa-miR-361-5p PPP3CB 0.21454431962475 0.0800957579368424 -0.217161149975175 0.026537796620393 miRanda -0.127974103120468 0.000592380004256261 NA NA NA hsa-miR-361-5p PPP3CC 0.21454431962475 0.0800957579368424 -0.864879436917075 5.11810186256782e-12 miRanda -0.162282770575647 0.000912467378574366 NA NA NA hsa-miR-181a-5p PPP3R1 -0.375429731222937 0.0562142867129802 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.174665544764319 9.40491398689482e-15 NA NA NA hsa-miR-181b-5p PPP3R1 0.668793269169928 0.000239998092406404 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.114349020464675 3.84750784901666e-06 NA NA NA hsa-miR-181c-5p PPP3R1 0.529875814537156 0.0125885822998008 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.106737924157465 4.8061231789594e-07 NA NA NA hsa-miR-27b-3p PPP3R1 0.236438984240408 0.12263510345883 -0.021451907795778 0.828812244123992 miRNATAP -0.122284709618602 4.10399666262129e-05 NA NA NA hsa-miR-30b-5p PPP3R1 0.358144314839612 0.138026229059594 -0.021451907795778 0.828812244123992 MirTarget -0.109418887183495 3.74739901258502e-09 NA NA NA hsa-miR-30c-5p PPP3R1 -0.327319105755825 0.123595832152687 -0.021451907795778 0.828812244123992 MirTarget;miRNATAP -0.157231202749467 5.03548982239333e-14 NA NA NA hsa-miR-342-3p PPP3R1 -0.128691966564961 0.561034080130801 -0.021451907795778 0.828812244123992 MirTarget;miRanda;miRNATAP -0.120856614371424 2.53668736670026e-09 NA NA NA hsa-miR-34a-5p PPP3R1 1.40588612517769 8.60097477768592e-12 -0.021451907795778 0.828812244123992 miRNAWalker2_validate -0.170360603226023 4.36468130338985e-16 NA NA NA hsa-let-7a-3p PRKACB 0.167285443861993 0.431834813181487 -0.337490057919314 0.0956151593593903 MirTarget;mirMAP;miRNATAP -0.109621340434496 0.0264314696722877 NA NA NA hsa-miR-141-3p PRKACB 3.36993755486106 5.42939251147195e-32 -0.337490057919314 0.0956151593593903 MirTarget;TargetScan;miRNATAP -0.127873218774198 2.27329955972899e-05 NA NA NA hsa-miR-146b-5p PRKACB 1.0922867893808 5.63754607494775e-06 -0.337490057919314 0.0956151593593903 miRanda -0.16173584971976 2.34820463010476e-05 NA NA NA hsa-miR-16-2-3p PRKACB 0.503964803530872 0.0263648405197492 -0.337490057919314 0.0956151593593903 mirMAP -0.126437256197819 0.00465216057285952 NA NA NA hsa-miR-17-5p PRKACB 2.07078488653279 2.77403038572568e-19 -0.337490057919314 0.0956151593593903 TargetScan -0.146235921583623 0.000160820334409303 NA NA NA hsa-miR-182-5p PRKACB 3.21839823004635 5.13049145201115e-39 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.112248448456467 0.00121734908239389 NA NA NA hsa-miR-183-5p PRKACB 2.39247234736657 3.92444525331999e-21 -0.337490057919314 0.0956151593593903 MirTarget -0.10185724563834 0.0037757174706069 NA NA NA hsa-miR-19a-3p PRKACB 2.11776595911517 7.07663078397156e-10 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.170735517959884 5.74076627300856e-08 NA NA NA hsa-miR-19b-3p PRKACB 2.10868505662119 5.40846613768389e-17 -0.337490057919314 0.0956151593593903 miRNAWalker2_validate;MirTarget;miRNATAP -0.197277470144974 1.27039043015725e-07 NA NA NA hsa-miR-200b-3p PRKACB 1.55157578247391 4.83790020897188e-09 -0.337490057919314 0.0956151593593903 MirTarget;TargetScan -0.101454883897731 0.00336247964553013 NA NA NA hsa-miR-200c-3p PRKACB 0.380533388300368 0.0842181838538353 -0.337490057919314 0.0956151593593903 MirTarget;miRNATAP -0.115374415768757 0.00655504187350906 NA NA NA hsa-miR-339-5p PRKACB 0.536997313601114 0.0488090394176611 -0.337490057919314 0.0956151593593903 miRanda -0.172209477372762 3.7061891291678e-07 NA NA NA hsa-miR-34a-5p PRKACB 1.40588612517769 8.60097477768592e-12 -0.337490057919314 0.0956151593593903 miRNATAP -0.249544715069385 1.25392359331725e-08 NA NA NA hsa-miR-362-5p PRKACB 0.658947634569393 0.0243306847205756 -0.337490057919314 0.0956151593593903 PITA -0.152310553896922 2.5944554975563e-06 NA NA NA hsa-miR-429 PRKACB 2.3794516574089 1.72813419703734e-13 -0.337490057919314 0.0956151593593903 MirTarget;PITA;miRanda;miRNATAP -0.120289214888389 7.31299726157361e-05 NA NA NA hsa-miR-590-5p PRKACB 2.07441240363458 4.95240551694843e-14 -0.337490057919314 0.0956151593593903 miRanda -0.106057390676399 0.00956598336443456 NA NA NA hsa-miR-93-5p PRKACB 1.50844106515467 1.83836866996875e-12 -0.337490057919314 0.0956151593593903 miRNAWalker2_validate -0.173603248772151 4.27230598908178e-05 NA NA NA hsa-miR-96-5p PRKACB 3.0381097138467 4.40362891630201e-24 -0.337490057919314 0.0956151593593903 miRNATAP -0.19117539499709 1.28710220181067e-08 NA NA NA hsa-miR-155-5p PRKAR1A 0.813513839059142 0.000608282725633232 -0.476850604449272 2.68687886515723e-05 miRNAWalker2_validate -0.139999488103335 1.05258302094743e-10 NA NA NA hsa-miR-186-5p PRKAR1A 0.852175445703945 6.88885738584309e-10 -0.476850604449272 2.68687886515723e-05 mirMAP -0.187471435255471 5.73112383343186e-07 NA NA NA hsa-miR-25-3p PRKAR1A 0.361927330834176 0.0163670566170988 -0.476850604449272 2.68687886515723e-05 miRNAWalker2_validate -0.132918419142272 0.000149714233560858 NA NA NA hsa-miR-30c-5p PRKAR1A -0.327319105755825 0.123595832152687 -0.476850604449272 2.68687886515723e-05 mirMAP -0.110647555772676 7.09317835691076e-06 NA NA NA hsa-miR-30e-5p PRKAR1A 1.60414100786743 3.78951090573667e-19 -0.476850604449272 2.68687886515723e-05 mirMAP -0.102557156521551 0.000277416995755017 NA NA NA hsa-miR-342-3p PRKAR1A -0.128691966564961 0.561034080130801 -0.476850604449272 2.68687886515723e-05 miRanda -0.195587101672966 2.00849194011625e-17 NA NA NA hsa-miR-590-3p PRKAR1A 0.83851360565783 0.00129224433453587 -0.476850604449272 2.68687886515723e-05 miRanda;mirMAP -0.137053164571483 8.41662596940527e-09 NA NA NA hsa-miR-590-5p PRKAR1A 2.07441240363458 4.95240551694843e-14 -0.476850604449272 2.68687886515723e-05 miRanda -0.195670821518842 1.25064405614133e-18 NA NA NA hsa-miR-96-5p PRKAR1A 3.0381097138467 4.40362891630201e-24 -0.476850604449272 2.68687886515723e-05 miRNAWalker2_validate;TargetScan;miRNATAP -0.128985822937838 6.61017716853541e-12 NA NA NA hsa-let-7a-3p PRKAR2A 0.167285443861993 0.431834813181487 -0.542111912815549 0.00820991566022701 mirMAP -0.129600545591328 0.00965385633423682 NA NA NA hsa-miR-103a-3p PRKAR2A 0.538497806383155 1.88134691850591e-05 -0.542111912815549 0.00820991566022701 miRNAWalker2_validate -0.182915804223543 0.0161204820560304 NA NA NA hsa-miR-106a-5p PRKAR2A 1.3902608059488 6.07931522284525e-05 -0.542111912815549 0.00820991566022701 mirMAP -0.182529692623676 9.11118517871937e-10 NA NA NA hsa-miR-106b-5p PRKAR2A 1.47447672652218 1.32004094930462e-13 -0.542111912815549 0.00820991566022701 mirMAP -0.130098878664838 0.00508433606379257 NA NA NA hsa-miR-10a-3p PRKAR2A 0.162369964979749 0.621747296513628 -0.542111912815549 0.00820991566022701 mirMAP -0.147560768203991 3.61634378140385e-05 NA NA NA hsa-miR-125a-5p PRKAR2A -1.04824536696301 3.97386082850476e-07 -0.542111912815549 0.00820991566022701 miRanda -0.119074803105274 0.00875043226956617 NA NA NA hsa-miR-142-5p PRKAR2A 1.29672439149353 4.0768822158894e-06 -0.542111912815549 0.00820991566022701 mirMAP -0.121135593752335 0.00078655285231452 NA NA NA hsa-miR-148a-3p PRKAR2A 2.30885799126944 1.95226081368985e-21 -0.542111912815549 0.00820991566022701 mirMAP -0.10473104721013 0.00495918694210131 NA NA NA hsa-miR-155-5p PRKAR2A 0.813513839059142 0.000608282725633232 -0.542111912815549 0.00820991566022701 miRNAWalker2_validate -0.146428684740871 0.000220862251552694 NA NA NA hsa-miR-16-5p PRKAR2A 0.749619098384047 4.11649450706988e-06 -0.542111912815549 0.00820991566022701 miRNAWalker2_validate -0.16233712492249 0.0052000527267614 NA NA NA hsa-miR-17-5p PRKAR2A 2.07078488653279 2.77403038572568e-19 -0.542111912815549 0.00820991566022701 mirMAP -0.158416749162573 5.53315845810464e-05 NA NA NA hsa-miR-20a-5p PRKAR2A 2.64649625616975 5.1469418982085e-27 -0.542111912815549 0.00820991566022701 mirMAP -0.177689732696527 8.05056914879578e-07 NA NA NA hsa-miR-21-5p PRKAR2A 4.38165933891779 1.52536633902505e-92 -0.542111912815549 0.00820991566022701 mirMAP -0.150363567953701 2.70425744412111e-05 NA NA NA hsa-miR-26b-5p PRKAR2A 0.72362441215247 4.7794659748036e-05 -0.542111912815549 0.00820991566022701 mirMAP -0.254835302085191 1.33543677793609e-06 NA NA NA hsa-miR-29a-5p PRKAR2A 1.89519956688438 1.03453349363915e-11 -0.542111912815549 0.00820991566022701 mirMAP -0.144340188354051 0.000269848610546557 NA NA NA hsa-miR-32-5p PRKAR2A 0.876853679269853 6.04859399018691e-05 -0.542111912815549 0.00820991566022701 mirMAP -0.149276001882109 0.00141193110732772 NA NA NA hsa-miR-582-5p PRKAR2A 1.08286181406653 0.00149040450161757 -0.542111912815549 0.00820991566022701 miRNATAP -0.106418125415066 0.000164630904331123 NA NA NA hsa-miR-590-5p PRKAR2A 2.07441240363458 4.95240551694843e-14 -0.542111912815549 0.00820991566022701 mirMAP -0.169616630819392 4.04701086495302e-05 NA NA NA hsa-miR-708-3p PRKAR2A 3.43841959417743 4.40027692981683e-28 -0.542111912815549 0.00820991566022701 mirMAP -0.130264413500301 3.805520704434e-05 NA NA NA hsa-miR-186-5p PRKAR2B 0.852175445703945 6.88885738584309e-10 -0.603510949504182 0.0393539020155484 mirMAP -0.203735577280849 0.0366327794799357 NA NA NA hsa-miR-361-5p PRKAR2B 0.21454431962475 0.0800957579368424 -0.603510949504182 0.0393539020155484 miRanda -0.33231834049798 0.00308352468710608 NA NA NA hsa-miR-92a-3p PRKAR2B -0.136362762339122 0.493412263619364 -0.603510949504182 0.0393539020155484 miRNATAP -0.152470358659526 0.0256836387516207 NA NA NA hsa-miR-450b-5p PRKX 1.69248953402469 1.96052058003353e-07 -0.138434262119447 0.395012462656297 mirMAP -0.119346741491602 2.11739235739311e-06 NA NA NA hsa-miR-542-3p PRKX 1.62226640768239 2.6427102465476e-10 -0.138434262119447 0.395012462656297 mirMAP -0.149271020180693 1.30948834311169e-07 NA NA NA hsa-miR-26a-5p PTDSS1 -0.126411409001078 0.440028840408711 0.014323601906522 0.904640686008302 mirMAP -0.140974234552484 2.77743218630916e-05 NA NA NA hsa-miR-26a-5p PTTG1 -0.126411409001078 0.440028840408711 2.29967103891773 7.51122159159736e-16 miRNAWalker2_validate -0.404247341427357 1.14869729062631e-06 NA NA NA hsa-miR-26a-5p RAB3B -0.126411409001078 0.440028840408711 2.32707741194992 7.77692669177197e-05 mirMAP -0.758988325914963 5.91278512140696e-06 NA NA NA hsa-miR-26a-5p RAB6B -0.126411409001078 0.440028840408711 0.426395028584002 0.120299691474674 mirMAP -0.210769153379731 0.00691691758102342 NA NA NA hsa-miR-26a-5p REEP4 -0.126411409001078 0.440028840408711 0.315984168124229 0.0150083922804493 MirTarget;miRNATAP -0.183475745136519 5.15178842554797e-07 NA NA NA hsa-miR-26a-5p RFFL -0.126411409001078 0.440028840408711 0.426721617234353 0.000558496428099858 mirMAP -0.142103697458207 5.00973000372684e-05 NA NA NA hsa-miR-26a-5p RGS4 -0.126411409001078 0.440028840408711 0.196887922136346 0.564222419675049 MirTarget;miRNATAP -0.225061414925735 0.0204744481238227 NA NA NA hsa-miR-26a-5p RRM2 -0.126411409001078 0.440028840408711 2.86899871288903 2.94977476028636e-19 miRNAWalker2_validate -0.684477705219282 1.29123506933786e-13 NA NA NA hsa-miR-26a-5p RRP7A -0.126411409001078 0.440028840408711 0.375108963937195 0.0105734323893765 mirMAP -0.162901148752773 8.79399293597485e-05 NA NA NA hsa-miR-26a-5p SACS -0.126411409001078 0.440028840408711 0.271986545539879 0.121028594980551 MirTarget;miRNATAP -0.131333555590876 0.00838769741303311 NA NA NA hsa-miR-26a-5p SAMD8 -0.126411409001078 0.440028840408711 -0.201264705201723 0.177392008185443 MirTarget;miRNATAP -0.114516996296308 0.00681298944120092 NA NA NA hsa-miR-26a-5p SBNO1 -0.126411409001078 0.440028840408711 0.218633910021256 0.259585297783949 mirMAP;miRNATAP -0.199343874146769 0.000281149849187749 NA NA NA hsa-miR-26a-5p SENP5 -0.126411409001078 0.440028840408711 0.170944468360906 0.112988192741522 MirTarget;miRNATAP -0.125912018630905 3.36195796475594e-05 NA NA NA hsa-miR-26a-5p SERBP1 -0.126411409001078 0.440028840408711 0.232311646569641 0.0179938483001303 miRNAWalker2_validate;miRTarBase;MirTarget;mirMAP;miRNATAP -0.116042017432216 2.7012620210206e-05 27449037 Loss of miR 26a 5p promotes proliferation migration and invasion in prostate cancer through negatively regulating SERBP1; Using bioinformatics analysis we found that serpine1 messenger RNA mRNA binding protein 1 SERBP1 was a potential downstream target of miR-26a-5p; Using luciferase reporter and western blot we identified that miR-26a-5p negatively regulated SERBP1 on the PC cell line level; Additionally SERBP1 was identified as a downstream target of miR-26a-5p; Taken together our results for the first time demonstrate that the loss of miR-26a-5p promotes proliferation migration and invasion through targeting SERBP1 in PC supporting the tumor-suppressing role of miR-26a-5p in PC prostate cancer hsa-miR-26a-5p SFPQ -0.126411409001078 0.440028840408711 0.402743406767234 8.60211558041654e-06 MirTarget -0.100072491193864 9.74624230768174e-05 NA NA NA hsa-miR-26a-5p SFXN1 -0.126411409001078 0.440028840408711 1.44719603382287 8.17405309534878e-22 MirTarget -0.247194009724498 2.389590700727e-08 NA NA NA hsa-miR-26a-5p SH3BP2 -0.126411409001078 0.440028840408711 -0.177046443326433 0.196425689010702 mirMAP -0.127681612503964 0.000991678882738019 NA NA NA hsa-miR-26a-5p SKP2 -0.126411409001078 0.440028840408711 0.717491763754031 0.00193527376559042 MirTarget -0.344578615119354 1.32474185351954e-07 NA NA NA hsa-miR-26a-5p SLC39A14 -0.126411409001078 0.440028840408711 0.3112660848419 0.144979904125944 mirMAP -0.219435609421123 0.000285837039721376 NA NA NA hsa-miR-26a-5p SLC7A11 -0.126411409001078 0.440028840408711 2.66698751984437 1.54033004932319e-08 miRNATAP -0.454699758049495 0.000824827424589449 NA NA NA hsa-miR-26a-5p SPOCK1 -0.126411409001078 0.440028840408711 1.70903703280186 0.000671735079673281 mirMAP -0.525501285411029 0.000242736813580234 NA NA NA hsa-miR-26a-5p SRPK1 -0.126411409001078 0.440028840408711 1.47133479015789 2.65570317055346e-24 miRNATAP -0.169971099410312 7.97986675265026e-05 NA NA NA hsa-miR-26a-5p SSX2IP -0.126411409001078 0.440028840408711 0.506864070381275 0.0076135247073222 MirTarget;miRNATAP -0.225979399571408 2.65272505447359e-05 NA NA NA hsa-miR-26a-5p STMN1 -0.126411409001078 0.440028840408711 0.714015868848262 0.00218062135194851 miRNATAP -0.267772865897944 5.16652843135063e-05 NA NA NA hsa-miR-26a-5p SULF1 -0.126411409001078 0.440028840408711 1.69578952100777 1.25423223192775e-06 MirTarget;miRNATAP -0.377384084202654 0.000167280817947028 NA NA NA hsa-miR-26a-5p SUZ12 -0.126411409001078 0.440028840408711 0.492315482875409 9.57075781113426e-05 miRNATAP -0.146363122059953 4.40562986017982e-05 NA NA NA hsa-miR-26a-5p SYT7 -0.126411409001078 0.440028840408711 2.6105278424188 1.97386553274303e-10 mirMAP -0.329834718543743 0.00559727490651966 NA NA NA hsa-miR-26a-5p TAF5 -0.126411409001078 0.440028840408711 0.388278432661178 0.00227371322020449 miRNATAP -0.14468659362648 5.89688140308431e-05 NA NA NA hsa-miR-26a-5p TBC1D16 -0.126411409001078 0.440028840408711 0.345597272254261 0.0587525206050741 miRNAWalker2_validate -0.290604832138783 1.45507657488046e-08 NA NA NA hsa-miR-26a-5p TCP1 -0.126411409001078 0.440028840408711 0.222053980153833 0.069695601131034 miRNAWalker2_validate -0.142729274211598 3.55115251889761e-05 NA NA NA hsa-miR-26a-5p TET1 -0.126411409001078 0.440028840408711 1.15474049376582 1.6976203546407e-06 miRNATAP -0.21695744781067 0.00172651271554746 NA NA NA hsa-miR-26a-5p TFAP2A -0.126411409001078 0.440028840408711 3.63118958402229 8.17898472391641e-17 miRNATAP -0.383401464702457 0.00282032850472759 NA NA NA hsa-miR-26a-5p TKT -0.126411409001078 0.440028840408711 0.530383489348534 0.00301432204517301 miRNAWalker2_validate -0.173710476486243 0.000632387438433738 NA NA NA hsa-miR-26a-5p TMEM184B -0.126411409001078 0.440028840408711 0.0941766120464127 0.462380405521902 MirTarget;miRNATAP -0.182688768151767 3.67111462310608e-07 NA NA NA hsa-miR-26a-5p TMEM189 -0.126411409001078 0.440028840408711 0.175881223086224 0.177366297524708 MirTarget;miRNATAP -0.164637910237467 7.24019012793754e-06 NA NA NA hsa-miR-26a-5p TMEM38B -0.126411409001078 0.440028840408711 -0.0646912191448394 0.75952374328622 MirTarget -0.137570470537238 0.0219516516433609 NA NA NA hsa-miR-26a-5p TMTC3 -0.126411409001078 0.440028840408711 0.197015311797843 0.186747920068746 miRNATAP -0.172212131551869 4.32398067407306e-05 NA NA NA hsa-miR-107 TNF 0.658676029898313 5.11480446318819e-07 -0.830982767486341 0.0138827131679617 miRanda -0.439603202171767 0.000221374639268502 NA NA NA hsa-miR-203a-3p TNF 1.06866854356847 0.00389979689199624 -0.830982767486341 0.0138827131679617 miRTarBase -0.103500315237721 0.0136268268780759 NA NA NA hsa-miR-320b TNF 0.226640952564488 0.378818692487242 -0.830982767486341 0.0138827131679617 miRanda -0.148152717399537 0.0147197238778624 NA NA NA hsa-miR-429 TNF 2.3794516574089 1.72813419703734e-13 -0.830982767486341 0.0138827131679617 miRNATAP -0.135544464882007 0.00782170177882693 NA NA NA hsa-miR-362-3p TNFRSF10A 0.194097672030785 0.52808475179225 0.313937445636065 0.126469321676362 miRanda -0.171482203608969 7.28861591280272e-06 NA NA NA hsa-miR-940 TNFRSF10B 0.011138136211269 0.974925352379525 0.178447201136893 0.311593856462823 miRNAWalker2_validate -0.141318772516878 2.62411186947218e-08 NA NA NA hsa-miR-193a-3p TNFRSF10C 0.549173467360291 0.0319030569365466 -0.154947494831521 0.59571603471051 miRanda -0.290120931664436 2.74949804872591e-07 NA NA NA hsa-miR-361-5p TNFRSF10C 0.21454431962475 0.0800957579368424 -0.154947494831521 0.59571603471051 miRanda -0.237444664053092 0.0339776756633854 NA NA NA hsa-miR-362-3p TNFRSF10D 0.194097672030785 0.52808475179225 -1.03846175939343 8.86767948326941e-06 miRanda -0.100403304163926 0.0233388202604092 NA NA NA hsa-miR-590-3p TNFRSF10D 0.83851360565783 0.00129224433453587 -1.03846175939343 8.86767948326941e-06 miRanda -0.116986382261948 0.0191591361661586 NA NA NA hsa-miR-590-5p TNFRSF10D 2.07441240363458 4.95240551694843e-14 -1.03846175939343 8.86767948326941e-06 miRanda -0.154057594157847 0.00120741838184007 NA NA NA hsa-miR-7-1-3p TNFRSF10D 2.61364240402652 1.98959237815786e-32 -1.03846175939343 8.86767948326941e-06 mirMAP -0.136420129073792 0.00490554426295682 NA NA NA hsa-miR-26a-5p TNPO1 -0.126411409001078 0.440028840408711 0.251738379349596 0.0349260355369059 MirTarget -0.103749228005688 0.0021471777988389 NA NA NA hsa-miR-140-3p TRAF2 -1.11373309124537 8.35257079443689e-14 1.00807946070122 6.3314135046518e-09 MirTarget -0.244688143587184 4.1120893831993e-06 NA NA NA hsa-miR-26a-5p TRAP1 -0.126411409001078 0.440028840408711 1.05008087041369 5.75590482780164e-16 miRNAWalker2_validate -0.171629335008955 5.47064507152997e-06 NA NA NA hsa-miR-26a-5p TRIM65 -0.126411409001078 0.440028840408711 0.399807075884659 0.00122017539272178 MirTarget -0.158276622075144 5.8662903162564e-06 NA NA NA hsa-miR-26a-5p TTPAL -0.126411409001078 0.440028840408711 0.628362943668103 3.85953011124262e-07 MirTarget -0.113741081759352 0.00133900683026378 NA NA NA hsa-miR-26a-5p TUBG1 -0.126411409001078 0.440028840408711 0.937443024309829 9.12437304120976e-10 miRNAWalker2_validate -0.394377428357969 1.54567915423733e-20 NA NA NA hsa-miR-26a-5p TWF1 -0.126411409001078 0.440028840408711 0.836013190055379 3.51260651137057e-08 MirTarget;miRNATAP -0.139366258792442 0.00139205527084307 NA NA NA hsa-miR-26a-5p UBA2 -0.126411409001078 0.440028840408711 0.288968307581134 0.0302353836489378 miRNAWalker2_validate -0.130864671991132 0.000528386195515407 NA NA NA hsa-miR-26a-5p UBE2H -0.126411409001078 0.440028840408711 0.456291647030759 0.000501298883563147 MirTarget;miRNATAP -0.133790107009631 0.00032857731610634 NA NA NA hsa-miR-26a-5p UBE2V2 -0.126411409001078 0.440028840408711 0.556674060608279 0.000112013341561722 mirMAP -0.192815746679638 2.32280871501292e-06 NA NA NA hsa-miR-26a-5p UBTF -0.126411409001078 0.440028840408711 0.185623331154604 0.0144628644698491 miRNAWalker2_validate;miRNATAP -0.119121373016874 1.68187459282983e-08 NA NA NA hsa-miR-26a-5p UBXN7 -0.126411409001078 0.440028840408711 0.0476095815672188 0.794620771591598 mirMAP -0.120285807258546 0.0205458284923217 NA NA NA hsa-miR-26a-5p UGGT1 -0.126411409001078 0.440028840408711 0.51003740287431 0.000134136989865437 MirTarget -0.14006192400646 0.000226778687422962 NA NA NA hsa-miR-26a-5p UHRF1BP1 -0.126411409001078 0.440028840408711 0.363185114425452 0.00984039826106316 MirTarget -0.126024167763497 0.00160216238316587 NA NA NA hsa-miR-26a-5p ULK1 -0.126411409001078 0.440028840408711 0.616445128058068 4.11216950040876e-05 miRNATAP -0.295199126819406 2.16699649045898e-12 NA NA NA hsa-miR-26a-5p UNC13A -0.126411409001078 0.440028840408711 0.611637394494186 0.157159453486073 mirMAP -0.252099382986489 0.0406807760168422 NA NA NA hsa-miR-26a-5p USP31 -0.126411409001078 0.440028840408711 -0.0028555707633533 0.984048217755574 mirMAP -0.176903305876641 1.07914971162245e-05 NA NA NA hsa-miR-26a-5p VANGL1 -0.126411409001078 0.440028840408711 0.482522450244504 0.00121744978200244 mirMAP -0.163660052828943 0.000110599784973222 NA NA NA hsa-miR-26a-5p VAPB -0.126411409001078 0.440028840408711 0.0615581473842584 0.602763031760505 mirMAP -0.109288659069746 0.00106779548950657 NA NA NA hsa-miR-26a-5p VDAC1 -0.126411409001078 0.440028840408711 0.566826279402601 2.22979244082283e-05 miRNATAP -0.116903554293692 0.00219456141453893 NA NA NA hsa-miR-140-3p XIAP -1.11373309124537 8.35257079443689e-14 0.311178443599883 0.00189888955771199 mirMAP -0.134806533023976 7.86246400028474e-06 NA NA NA hsa-miR-17-5p XIAP 2.07078488653279 2.77403038572568e-19 0.311178443599883 0.00189888955771199 miRNAWalker2_validate;TargetScan -0.104621962395686 3.56642452518644e-08 NA NA NA hsa-miR-186-5p XIAP 0.852175445703945 6.88885738584309e-10 0.311178443599883 0.00189888955771199 MirTarget;miRNATAP -0.106770220904771 0.00127610812666367 NA NA NA hsa-miR-25-3p XIAP 0.361927330834176 0.0163670566170988 0.311178443599883 0.00189888955771199 mirMAP -0.105648114201262 0.000601509319956213 NA NA NA hsa-miR-484 XIAP -0.228576985124486 0.244112867390855 0.311178443599883 0.00189888955771199 mirMAP -0.110023475185489 2.657115273949e-06 NA NA NA hsa-miR-92a-3p XIAP -0.136362762339122 0.493412263619364 0.311178443599883 0.00189888955771199 mirMAP -0.115780408737922 5.14759041621164e-07 NA NA NA hsa-miR-26a-5p XPOT -0.126411409001078 0.440028840408711 0.842277783138104 5.54099502941227e-07 mirMAP -0.20902849890403 1.35685330673363e-05 NA NA NA hsa-miR-26a-5p YES1 -0.126411409001078 0.440028840408711 0.0716555082187087 0.625670821706797 miRNATAP -0.150717787846919 0.00028074451344835 NA NA NA hsa-miR-26a-5p ZNF286A -0.126411409001078 0.440028840408711 0.321534155603346 0.0402725661282039 mirMAP -0.155729447556689 0.000454829034376199 NA NA NA hsa-miR-26a-5p ZNF598 -0.126411409001078 0.440028840408711 0.734104266054326 7.51854095325325e-07 MirTarget -0.267711225906071 1.57290665186045e-10 NA NA NA hsa-miR-26a-5p ZNF623 -0.126411409001078 0.440028840408711 0.598799723685322 4.202262729275e-05 mirMAP -0.123648869782966 0.00306661867712119 NA NA NA hsa-miR-26a-5p ZNF697 -0.126411409001078 0.440028840408711 0.0296257625014902 0.86856215591802 miRNATAP -0.154415235875622 0.00233180978519324 NA NA NA hsa-miR-26a-5p ZNF813 -0.126411409001078 0.440028840408711 -0.026418906386003 0.897273131364056 mirMAP -0.125057082318341 0.0315036402735522 NA NA NA