miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-let-7a-3p ABCA1 0.215598045625678 0.85543299203799 0.0310390761643538 0.976450528159164 mirMAP;miRNATAP -0.394383684923022 1.77995786346008e-07 NA NA NA hsa-let-7a-3p ABCC9 0.215598045625678 0.85543299203799 -0.593188200168152 0.222493617717337 mirMAP -0.796613815830176 1.97147188651006e-12 NA NA NA hsa-let-7a-3p ABCD2 0.215598045625678 0.85543299203799 0.41664882433793 0.495908768718213 mirMAP -0.513737031086163 4.54162334876976e-05 NA NA NA hsa-let-7a-3p ABI3BP 0.215598045625678 0.85543299203799 0.353071867299822 0.57111184892474 miRNATAP -0.620967300885678 1.88010351647496e-05 NA NA NA hsa-let-7a-3p ACVR1 0.215598045625678 0.85543299203799 -0.0993016655168191 0.928947502751759 MirTarget;miRNATAP -0.117231784088334 0.000243196209904912 NA NA NA hsa-let-7a-3p ADAM23 0.215598045625678 0.85543299203799 -0.21950472892157 0.685160494702443 mirMAP -0.964187841730036 1.80257849942225e-11 NA NA NA hsa-let-7a-3p ADAMTS5 0.215598045625678 0.85543299203799 -0.460647326807058 0.448771958927598 mirMAP -0.356905380272848 5.05628652022576e-07 NA NA NA hsa-let-7a-3p ADAMTSL3 0.215598045625678 0.85543299203799 -0.622708217823632 0.256590387527616 MirTarget -1.13837970040903 1.17619893382785e-13 NA NA NA hsa-let-7a-3p ADCYAP1 0.215598045625678 0.85543299203799 -0.900163050907172 0.193782704569993 miRNATAP -1.11740690500738 7.77041027107581e-10 NA NA NA hsa-let-7a-3p ADD2 0.215598045625678 0.85543299203799 -0.591573146087411 0.48027130463771 mirMAP -0.741173835817103 3.07352298879595e-06 NA NA NA hsa-let-7a-3p AFF2 0.215598045625678 0.85543299203799 -0.0995918386413326 0.896629105024407 mirMAP -0.35130037178478 0.0119966997802438 NA NA NA hsa-let-7a-3p AFF3 0.215598045625678 0.85543299203799 0.0711967837874513 0.879517438022228 MirTarget -0.459326001830164 0.000481519431358232 NA NA NA hsa-let-7a-3p AKAP12 0.215598045625678 0.85543299203799 -0.669938437506524 0.545273296816437 miRNATAP -0.88403230439673 7.40686178733717e-12 NA NA NA hsa-let-7a-3p ALDH1L2 0.215598045625678 0.85543299203799 -0.658432674257849 0.345765201073045 MirTarget -0.496138863624185 3.79571907568601e-06 NA NA NA hsa-let-7a-3p AMIGO2 0.215598045625678 0.85543299203799 -0.843178816472818 0.41846274287768 MirTarget;mirMAP -0.389911459303788 4.87417185737882e-05 NA NA NA hsa-let-7a-3p AMOTL1 0.215598045625678 0.85543299203799 -0.321735094517482 0.727218948007748 mirMAP -0.641446459128087 1.2129988456844e-09 NA NA NA hsa-let-7a-3p ANKRD50 0.215598045625678 0.85543299203799 0.16949874726168 0.872836783059216 mirMAP -0.185095743631623 4.16567134094576e-05 NA NA NA hsa-let-7a-3p ANO5 0.215598045625678 0.85543299203799 -1.54323345126756 0.0319850480913266 mirMAP -0.585547307586012 0.0025638432261358 NA NA NA hsa-let-7a-3p ANTXR1 0.215598045625678 0.85543299203799 -0.405220925607642 0.789750261639452 mirMAP;miRNATAP -0.790155001239989 3.73942026614096e-11 NA NA NA hsa-miR-106b-5p APC 0.297128724729338 0.86929444354075 -0.196794568986727 0.852946173267447 miRNAWalker2_validate;miRTarBase -0.221090416247696 2.74224832837052e-06 23087084 miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells liver cancer hsa-miR-148a-3p APC 0.101286586375016 0.976980454193186 -0.196794568986727 0.852946173267447 miRNAWalker2_validate -0.11689005190455 0.00640789868321619 NA NA NA hsa-miR-154-3p APC 0.170366170038505 0.546500133020447 -0.196794568986727 0.852946173267447 TargetScan -0.11742585355327 0.00356137566396406 NA NA NA hsa-miR-192-5p APC 0.117345487848226 0.972927287653136 -0.196794568986727 0.852946173267447 miRNAWalker2_validate -0.113719244280745 0.000540682729973804 NA NA NA hsa-miR-193a-3p APC 0.247265785363731 0.654363581941635 -0.196794568986727 0.852946173267447 miRanda -0.150390924294565 0.000107999447451728 NA NA NA hsa-miR-27a-3p APC 0.123902317731458 0.958804393510999 -0.196794568986727 0.852946173267447 miRNAWalker2_validate;miRTarBase;miRNATAP -0.172640999838069 0.00983801888943467 22018270 Finally the APC gene was identified as the direct and functional target of miR-27 gastric cancer hsa-miR-335-3p APC 0.244830745789441 0.884500191166311 -0.196794568986727 0.852946173267447 mirMAP -0.214685562769503 6.31038682998398e-09 NA NA NA hsa-miR-374a-5p APC 0.343007247142618 0.766921280269271 -0.196794568986727 0.852946173267447 mirMAP -0.283252682346721 1.3727422438847e-06 NA NA NA hsa-miR-374b-5p APC 0.285682091626877 0.835698304799651 -0.196794568986727 0.852946173267447 mirMAP -0.202348624592442 0.000440637961909132 NA NA NA hsa-miR-421 APC 0.182032017078617 0.734704500318599 -0.196794568986727 0.852946173267447 miRanda -0.147549411526102 0.00019991634323926 NA NA NA hsa-miR-450b-5p APC 0.0136687538973108 0.983149761399849 -0.196794568986727 0.852946173267447 miRNATAP -0.17244181378059 6.24983424543036e-05 NA NA NA hsa-miR-501-3p APC 0.753812576327833 0.552763280802254 -0.196794568986727 0.852946173267447 TargetScan -0.120932259670203 0.00171395840019733 NA NA NA hsa-miR-590-3p APC 0.27924475537686 0.591266699336619 -0.196794568986727 0.852946173267447 PITA;miRanda;mirMAP;miRNATAP -0.10191760855962 0.00339239832008087 NA NA NA hsa-miR-199a-5p APC2 -0.157247797504494 0.935797462797012 0.381720873846146 0.363749276154213 mirMAP -0.251440276365729 0.0135224860654152 NA NA NA hsa-miR-20a-3p APC2 -0.456808229166029 0.576740561365039 0.381720873846146 0.363749276154213 mirMAP -0.165842843423182 0.0095606046251902 NA NA NA hsa-miR-221-5p APC2 -0.0797468413208207 0.897597103192106 0.381720873846146 0.363749276154213 mirMAP -0.152177744284051 0.0252386721529223 NA NA NA hsa-miR-452-3p APC2 0.167134177977311 0.799008246175244 0.381720873846146 0.363749276154213 mirMAP -0.168552343103693 0.00952847701626536 NA NA NA hsa-miR-500a-3p APC2 0.633375813338737 0.732582832733154 0.381720873846146 0.363749276154213 mirMAP -0.232611519995228 0.0116423143999811 NA NA NA hsa-let-7a-3p AQP9 0.215598045625678 0.85543299203799 0.0320079884964661 0.963556259237215 MirTarget -0.887862994777131 1.57507476611909e-06 NA NA NA hsa-let-7a-3p ARHGAP20 0.215598045625678 0.85543299203799 -0.292456863018204 0.534742105853332 MirTarget;miRNATAP -0.605518487037414 9.70256361522864e-07 NA NA NA hsa-let-7a-3p ARHGAP28 0.215598045625678 0.85543299203799 0.0214689242582863 0.954117166281858 mirMAP -0.388117928306008 0.000254804873304825 NA NA NA hsa-let-7a-3p ARHGAP29 0.215598045625678 0.85543299203799 -0.159084942567013 0.861949117892727 mirMAP -0.265428410890195 0.000254888368223575 NA NA NA hsa-let-7a-3p ARL10 0.215598045625678 0.85543299203799 -0.2073707058784 0.630679747653663 mirMAP -0.549585114986142 4.92971421535688e-08 NA NA NA hsa-let-7a-3p ARSB 0.215598045625678 0.85543299203799 0.252305282957892 0.776825641826072 mirMAP -0.165675897686895 0.00257868692894442 NA NA NA hsa-let-7a-3p ASAH1 0.215598045625678 0.85543299203799 0.385659701498136 0.808789615248136 MirTarget -0.13951925242809 0.00224639347907709 NA NA NA hsa-let-7a-3p ASAP1 0.215598045625678 0.85543299203799 -0.410212129040699 0.734256954706543 mirMAP -0.187881190162935 0.000595770723275848 NA NA NA hsa-let-7a-3p ASXL2 0.215598045625678 0.85543299203799 0.151789508871031 0.89512371026919 mirMAP;miRNATAP -0.176965330744064 0.000809437071089838 NA NA NA hsa-let-7a-3p ATE1 0.215598045625678 0.85543299203799 0.273983710484849 0.75610659756684 mirMAP -0.13277241632481 0.00264806848344072 NA NA NA hsa-let-7a-3p ATF2 0.215598045625678 0.85543299203799 0.200040241393685 0.834704017881279 MirTarget;mirMAP;miRNATAP -0.145456257908776 3.85637550129781e-05 NA NA NA hsa-let-7a-3p ATP6AP2 0.215598045625678 0.85543299203799 0.0645853090608739 0.969105376877065 mirMAP -0.133226021289561 0.000270371833611246 NA NA NA hsa-let-7a-3p ATRN 0.215598045625678 0.85543299203799 0.416555414420258 0.74342379365993 miRNATAP -0.258091788449881 8.40362356608516e-05 NA NA NA hsa-let-7a-3p ATRX 0.215598045625678 0.85543299203799 0.0436458031487934 0.97476545209269 MirTarget;miRNATAP -0.130176029418471 0.000506004071240485 NA NA NA hsa-miR-34c-5p AXIN2 0.018707656771723 0.952788306178575 -0.161547979876199 0.922492848211098 miRanda -0.242362890234192 0.0238643764569222 NA NA NA hsa-miR-582-5p AXIN2 0.399450205475138 0.581227478860085 -0.161547979876199 0.922492848211098 miRNATAP -0.53581634834622 2.73561419818281e-06 NA NA NA hsa-let-7a-3p B3GALNT1 0.215598045625678 0.85543299203799 -0.714936529705616 0.204088247477028 mirMAP -0.371631816187024 0.000311189455579815 NA NA NA hsa-let-7a-3p BAG4 0.215598045625678 0.85543299203799 0.388408489814595 0.566693330842471 mirMAP -0.200722572872357 0.000210664173605654 NA NA NA hsa-let-7a-3p BASP1 0.215598045625678 0.85543299203799 -0.4157132322319 0.637387524608869 miRNATAP -0.463601920126025 1.50117173459404e-06 NA NA NA hsa-let-7a-3p BCL6 0.215598045625678 0.85543299203799 -0.0248809442633613 0.979137516882529 miRNATAP -0.16651967562707 0.00802160056137438 NA NA NA hsa-let-7a-3p BDNF 0.215598045625678 0.85543299203799 -0.502522334318129 0.169334891177907 MirTarget;miRNATAP -0.244157318378319 0.00935451173762819 NA NA NA hsa-let-7a-3p BEND4 0.215598045625678 0.85543299203799 -0.290659160627207 0.752434723805407 mirMAP -0.412645488232398 0.00473293101194993 NA NA NA hsa-let-7a-3p BEND6 0.215598045625678 0.85543299203799 -0.448764739366898 0.384577885223211 mirMAP -0.773159765711536 5.31963427031848e-11 NA NA NA hsa-let-7a-3p BICD2 0.215598045625678 0.85543299203799 0.0142350728959011 0.990108428232535 mirMAP -0.104107313882164 0.00471573639215664 NA NA NA hsa-let-7a-3p BMP2K 0.215598045625678 0.85543299203799 0.170494281686867 0.844833488125619 mirMAP -0.165827539788636 6.07822821190309e-05 NA NA NA hsa-let-7a-3p BMP3 0.215598045625678 0.85543299203799 -1.03897717571709 0.204516239788851 MirTarget;mirMAP -0.82259273975373 0.000293324712749253 NA NA NA hsa-let-7a-3p BMPR1B 0.215598045625678 0.85543299203799 -0.0279271569584354 0.966006292298003 miRNATAP -0.60946605714919 0.000284017884491797 NA NA NA hsa-let-7a-3p BMPR2 0.215598045625678 0.85543299203799 -0.176365036427438 0.90000202997765 MirTarget;miRNATAP -0.175468885071709 0.000130019756231136 NA NA NA hsa-let-7a-3p BNC2 0.215598045625678 0.85543299203799 -0.302315625798064 0.611506554712371 mirMAP -0.769777962431435 8.56711149734912e-11 NA NA NA hsa-let-7a-3p BST1 0.215598045625678 0.85543299203799 -0.481514323585268 0.338161325733008 MirTarget -0.381485033338693 0.000238638114856813 NA NA NA hsa-let-7a-3p BTC 0.215598045625678 0.85543299203799 -0.00146968254039481 0.996381692454565 mirMAP -0.19821343513836 0.0028250929657907 NA NA NA hsa-let-7a-3p BVES 0.215598045625678 0.85543299203799 -0.393580951330034 0.303971638148629 mirMAP -0.635380857025591 4.74059040682731e-10 NA NA NA hsa-let-7a-3p CACNA1C 0.215598045625678 0.85543299203799 -0.624130328975344 0.478285757372738 MirTarget -0.227414575044299 0.0311177968520327 NA NA NA hsa-let-7a-3p CACNA2D1 0.215598045625678 0.85543299203799 -0.211496228686086 0.752243863025546 mirMAP -1.23589254201515 1.4930895850117e-13 NA NA NA hsa-let-7a-3p CACNG4 0.215598045625678 0.85543299203799 -1.66910865681926 0.0575060227978892 MirTarget -0.553741468397336 0.0340462674110164 NA NA NA hsa-miR-195-3p CACYBP -0.122473158217745 0.691917127032363 -0.0435559673396764 0.976925582631483 mirMAP -0.151794176709915 2.24952439329053e-07 NA NA NA hsa-miR-30a-3p CACYBP -0.250338313897394 0.917094926793447 -0.0435559673396764 0.976925582631483 MirTarget -0.232333100711769 6.31345446632718e-08 NA NA NA hsa-miR-182-5p CAMK2B 0.10423849794055 0.973380614062244 -2.17047179638848 0.00981662259739031 mirMAP -0.231408971042985 0.0499236678372187 NA NA NA hsa-miR-186-5p CAMK2B 0.318786974828755 0.854127229389611 -2.17047179638848 0.00981662259739031 miRNAWalker2_validate;miRNATAP -0.920452799641873 5.35166959877138e-07 NA NA NA hsa-miR-18a-5p CAMK2B 0.498318455303918 0.612640919755849 -2.17047179638848 0.00981662259739031 mirMAP -0.32652680243123 0.000780906706071633 NA NA NA hsa-miR-18b-5p CAMK2B 0.0473300652227538 0.899981261531446 -2.17047179638848 0.00981662259739031 mirMAP -0.206659223618872 0.0311608275321355 NA NA NA hsa-miR-335-5p CAMK2B 0.0284895175847679 0.973380867832231 -2.17047179638848 0.00981662259739031 mirMAP -0.297732382248847 0.0149836471839851 NA NA NA hsa-miR-34a-5p CAMK2B 0.50188164870224 0.742034237185732 -2.17047179638848 0.00981662259739031 mirMAP -0.282162488923971 0.0487750136045407 NA NA NA hsa-miR-362-3p CAMK2B 0.721040238345347 0.0345881362485733 -2.17047179638848 0.00981662259739031 miRanda -0.393573663761851 0.000260046149132286 NA NA NA hsa-miR-362-5p CAMK2B 0.26647467080141 0.752024885130738 -2.17047179638848 0.00981662259739031 miRNATAP -0.425054831724973 3.04925288722957e-05 NA NA NA hsa-miR-377-3p CAMK2B 0.0435868040110953 0.893514136702459 -2.17047179638848 0.00981662259739031 mirMAP -0.303120112450562 0.0101282043978609 NA NA NA hsa-miR-491-5p CAMK2B 0.585652105321328 0.0452620602586908 -2.17047179638848 0.00981662259739031 miRanda -0.235136882606436 0.0494435331813438 NA NA NA hsa-miR-577 CAMK2B 1.06238199218774 0.326056761787754 -2.17047179638848 0.00981662259739031 miRNATAP -0.327780232625455 1.48895659141036e-06 NA NA NA hsa-miR-589-3p CAMK2B 0.835836305204965 0.0112001563801511 -2.17047179638848 0.00981662259739031 MirTarget -0.471242264042232 3.88780893572071e-06 NA NA NA hsa-miR-590-3p CAMK2B 0.27924475537686 0.591266699336619 -2.17047179638848 0.00981662259739031 miRanda -0.417111526860007 0.000159240762694534 NA NA NA hsa-miR-625-5p CAMK2B 0.690759472145278 0.210306534567564 -2.17047179638848 0.00981662259739031 mirMAP -0.402774713768327 3.17411959747693e-05 NA NA NA hsa-miR-628-5p CAMK2B 0.508907702070671 0.351926682319915 -2.17047179638848 0.00981662259739031 miRNATAP -0.530677211997499 0.00189248229560732 NA NA NA hsa-miR-940 CAMK2B 0.225788347550697 0.680055767105815 -2.17047179638848 0.00981662259739031 PITA;miRNATAP -0.248002412691839 0.00939897429891113 NA NA NA hsa-miR-96-5p CAMK2B -0.0854810872029352 0.923087820185031 -2.17047179638848 0.00981662259739031 mirMAP -0.286063182565668 0.0124846183206831 NA NA NA hsa-miR-361-5p CAMK2D 0.138735309928775 0.941495130308343 0.328303276365629 0.804663028569463 PITA;miRanda;miRNATAP -0.150740709790179 0.0304439529743581 NA NA NA hsa-miR-542-3p CAMK2D -0.188168046511374 0.909252939431573 0.328303276365629 0.804663028569463 miRanda -0.105781817189162 0.0343931157015062 NA NA NA hsa-miR-708-3p CAMK2D -0.137785606206693 0.896980471394499 0.328303276365629 0.804663028569463 mirMAP -0.141079013249096 0.000231245836337699 NA NA NA hsa-miR-181a-5p CAMK2G -0.0295101956318309 0.989325168350124 -0.21456614554996 0.868392768639694 miRNATAP -0.102688844978283 0.00194951276730845 NA NA NA hsa-miR-181b-5p CAMK2G -0.155313039554487 0.930176779696506 -0.21456614554996 0.868392768639694 miRNATAP -0.100956135947566 0.00173481793066032 NA NA NA hsa-miR-30e-3p CAMK2G 0.220498559176349 0.938660731870214 -0.21456614554996 0.868392768639694 MirTarget -0.100993174825211 0.0458346370998349 NA NA NA hsa-miR-628-5p CAMK2G 0.508907702070671 0.351926682319915 -0.21456614554996 0.868392768639694 MirTarget;PITA;miRNATAP -0.167006149558629 1.34694775689948e-06 NA NA NA hsa-let-7a-3p CCDC102B 0.215598045625678 0.85543299203799 -0.453973822592161 0.156601864574767 MirTarget -0.293272750556617 0.000164877890790506 NA NA NA hsa-let-7a-3p CCDC50 0.215598045625678 0.85543299203799 -0.181949961786763 0.890300390742174 miRNATAP -0.140051504836908 4.07163609496076e-06 NA NA NA hsa-miR-15a-5p CCND1 0.0674049094129137 0.964835434214122 0.254128537418143 0.890666103231997 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.12854550315044 0.0156403747681216 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-15b-5p CCND1 0.272614787130879 0.870965418321879 0.254128537418143 0.890666103231997 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.103246325172398 0.0389737079787806 NA NA NA hsa-miR-16-5p CCND1 -0.0135949734723564 0.994476223855607 0.254128537418143 0.890666103231997 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.131352085119981 0.00823300401924536 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-195-5p CCND1 -0.343201952346823 0.749622318650888 0.254128537418143 0.890666103231997 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.135964440478054 0.00272099018653157 21350001;26631043;25823925 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma ;;metastasis;poor survival breast cancer;cervical and endocervical cancer;sarcoma hsa-miR-26b-5p CCND1 0.0245931278499594 0.990377966314923 0.254128537418143 0.890666103231997 miRNAWalker2_validate -0.126022649704212 0.033017104129409 NA NA NA hsa-miR-29c-3p CCND1 -0.1624517002027 0.94272045751251 0.254128537418143 0.890666103231997 mirMAP -0.140688238276882 0.00181263740987372 NA NA NA hsa-miR-301a-3p CCND2 0.10531251190177 0.831686745977346 0.169347673132288 0.920312633212099 miRNAWalker2_validate -0.180930203745166 0.0247671980791425 NA NA NA hsa-let-7a-3p CCPG1 0.215598045625678 0.85543299203799 -0.160178606169523 0.906216676148062 mirMAP -0.175144124000326 0.000156610020292179 NA NA NA hsa-let-7a-3p CD109 0.215598045625678 0.85543299203799 -0.243321877245513 0.788714007292392 mirMAP -0.583208413750158 6.63102420231812e-05 NA NA NA hsa-let-7a-3p CD302 0.215598045625678 0.85543299203799 -0.0492238734100763 0.960523647204344 mirMAP -0.169708841551481 0.00115537325166664 NA NA NA hsa-let-7a-3p CD38 0.215598045625678 0.85543299203799 0.275329850566827 0.619452376361521 MirTarget -0.662973472806657 3.72832939802592e-05 NA NA NA hsa-let-7a-3p CDC14A 0.215598045625678 0.85543299203799 -0.0233079363277784 0.970104144635327 mirMAP -0.151560721976898 0.00458491367698673 NA NA NA hsa-let-7a-3p CDC42EP3 0.215598045625678 0.85543299203799 -0.161798664489326 0.872548253281068 MirTarget;mirMAP -0.253735305226449 2.75687575139631e-05 NA NA NA hsa-let-7a-3p CDK17 0.215598045625678 0.85543299203799 0.131162643944522 0.895422249342714 MirTarget;miRNATAP -0.120856434480799 0.000221105594142108 NA NA NA hsa-let-7a-3p CDS2 0.215598045625678 0.85543299203799 0.140790898855318 0.902293995130263 mirMAP -0.117511440085111 0.00961329526258796 NA NA NA hsa-let-7a-3p CFL2 0.215598045625678 0.85543299203799 -0.165638593614143 0.834125604099382 mirMAP -0.423188855982398 1.4619989682135e-09 NA NA NA hsa-miR-24-3p CHD8 0.0484778924256641 0.985274054814493 0.225763687675902 0.872067570290546 miRNAWalker2_validate -0.171709221547382 0.00182902940441724 NA NA NA hsa-let-7a-3p CHL1 0.215598045625678 0.85543299203799 -0.0983417248342554 0.862180724309222 MirTarget;miRNATAP -0.940270000366059 1.65583490176558e-09 NA NA NA hsa-let-7a-3p CHM 0.215598045625678 0.85543299203799 0.0330187709476748 0.97473790201879 MirTarget -0.133378457997774 0.0024619518309959 NA NA NA hsa-miR-1254 CHP2 0.488929355953681 0.19551794273322 -1.46960089468565 0.154796703887396 miRNATAP -0.409969255083918 0.024450757326671 NA NA NA hsa-let-7a-3p CHST2 0.215598045625678 0.85543299203799 0.00829109547008766 0.988370250594073 MirTarget -0.301524086892135 0.000198142665526285 NA NA NA hsa-let-7a-3p CLIC4 0.215598045625678 0.85543299203799 -0.322580503934854 0.834856393506392 MirTarget -0.382439466827813 2.65495753349232e-09 NA NA NA hsa-let-7a-3p CLIP1 0.215598045625678 0.85543299203799 0.00934629537026055 0.994588205278274 miRNATAP -0.127206514000832 2.54619217250927e-05 NA NA NA hsa-let-7a-3p CLOCK 0.215598045625678 0.85543299203799 0.107796378480728 0.904209882274776 MirTarget -0.118908374150107 0.0249788762355227 NA NA NA hsa-let-7a-3p CNR1 0.215598045625678 0.85543299203799 -0.408755667000371 0.592748629369966 mirMAP -0.906094370652042 1.877789620643e-07 NA NA NA hsa-let-7a-3p CNTN1 0.215598045625678 0.85543299203799 -0.700260823843555 0.422958433186703 MirTarget;miRNATAP -1.18704389515971 1.48178227033071e-10 NA NA NA hsa-let-7a-3p COL11A1 0.215598045625678 0.85543299203799 -0.443148789469867 0.715160375932875 MirTarget;miRNATAP -0.970828416782606 3.60625978003182e-08 NA NA NA hsa-let-7a-3p COL12A1 0.215598045625678 0.85543299203799 -0.319782253280853 0.858054351650501 miRNATAP -0.529060979448702 3.31516730177467e-07 NA NA NA hsa-let-7a-3p COL15A1 0.215598045625678 0.85543299203799 -0.292488023717008 0.84045401118465 MirTarget -0.43632167949533 2.21690161675284e-06 NA NA NA hsa-let-7a-3p COL1A2 0.215598045625678 0.85543299203799 -0.454328350754549 0.851346205358442 MirTarget -0.575582831050776 5.0312162680722e-07 NA NA NA hsa-let-7a-3p COL4A1 0.215598045625678 0.85543299203799 -0.390705250339177 0.843526595048209 miRNATAP -0.365653907996656 1.58962960214704e-07 NA NA NA hsa-let-7a-3p COL9A1 0.215598045625678 0.85543299203799 -1.11947038451616 0.119587299570099 mirMAP -0.487205306846043 0.0224978366733971 NA NA NA hsa-let-7a-3p CORO1C 0.215598045625678 0.85543299203799 0.113623375094892 0.946376250605846 MirTarget;miRNATAP -0.116389693188432 0.000187030529558234 NA NA NA hsa-let-7a-3p CPEB4 0.215598045625678 0.85543299203799 -0.266802742846457 0.798549931312957 mirMAP;miRNATAP -0.201019541093449 4.65984991816081e-05 NA NA NA hsa-miR-493-5p CREBBP -0.229930075372343 0.731979520100109 0.0709718431637612 0.963143997108612 miRNATAP -0.131589658655616 0.000363570308901921 NA NA NA hsa-let-7a-3p CRISPLD1 0.215598045625678 0.85543299203799 -0.38485070704001 0.449695952160106 MirTarget;miRNATAP -0.822643530971888 1.71176096439252e-10 NA NA NA hsa-miR-21-5p CSNK1A1 0.14892088710744 0.970240620972125 -0.0425031292154419 0.981068216393415 miRNAWalker2_validate -0.100143903180387 0.0124656036762396 NA NA NA hsa-miR-30e-5p CSNK1A1 0.0657075181380993 0.979684509181942 -0.0425031292154419 0.981068216393415 MirTarget -0.110082716517243 0.00277452335093186 NA NA NA hsa-miR-330-3p CSNK1A1L -0.00298687748748439 0.994504006750491 0.0920768620753871 0.905438482767361 PITA -0.160571453580249 0.0493390073339156 NA NA NA hsa-miR-26a-5p CSNK2A1 -0.00698202897992672 0.997719986197022 0.0735845620178255 0.959667032849258 mirMAP -0.15492028243364 0.0399484133558686 NA NA NA hsa-miR-146b-5p CSNK2A2 0.402662509440885 0.837510937985092 -0.0524660037558826 0.962117099008393 miRanda -0.169704038600773 3.42562008282362e-06 NA NA NA hsa-miR-212-3p CSNK2A2 0.0224067199236493 0.973232008101457 -0.0524660037558826 0.962117099008393 mirMAP -0.11553803543894 0.00415916216062692 NA NA NA hsa-miR-92b-3p CSNK2A2 0.569866984318693 0.689321861489778 -0.0524660037558826 0.962117099008393 mirMAP -0.107283711109916 0.000581971462246387 NA NA NA hsa-miR-140-5p CTNNB1 0.229213026275907 0.847330111738614 0.27160111865579 0.897380291117619 miRanda -0.136902680392965 0.00185084671259549 NA NA NA hsa-let-7a-3p CTSC 0.215598045625678 0.85543299203799 -0.00704146332799027 0.99666839432251 mirMAP -0.126134023071555 0.00791940714520071 NA NA NA hsa-let-7a-3p CUL4B 0.215598045625678 0.85543299203799 -0.0188300546695075 0.989560095961177 mirMAP -0.102533503984394 0.00249375242907953 NA NA NA hsa-let-7a-3p CX3CR1 0.215598045625678 0.85543299203799 0.433943540846652 0.293792618631752 MirTarget -0.649905828022335 3.34933773211936e-09 NA NA NA hsa-let-7a-3p CXXC4 0.215598045625678 0.85543299203799 -0.790601166401651 0.212175078787021 mirMAP -0.32036646653003 0.015765170146202 NA NA NA hsa-let-7f-1-3p CXXC4 0.31101436822914 0.693407210545374 -0.790601166401651 0.212175078787021 mirMAP -0.519409376894187 0.00404440222223057 NA NA NA hsa-miR-126-5p CXXC4 -0.0815213541035842 0.956637332055184 -0.790601166401651 0.212175078787021 MirTarget;mirMAP -0.430475686374969 0.00512692539803872 NA NA NA hsa-miR-130b-3p CXXC4 0.221667315324818 0.824660172394714 -0.790601166401651 0.212175078787021 miRNATAP -0.250237735136782 0.0430427225588232 NA NA NA hsa-miR-140-5p CXXC4 0.229213026275907 0.847330111738614 -0.790601166401651 0.212175078787021 miRanda -0.383159802188146 0.0293926535926335 NA NA NA hsa-miR-146a-5p CXXC4 0.581292803346902 0.736851349367572 -0.790601166401651 0.212175078787021 MirTarget -0.199841854412333 0.0485589070659373 NA NA NA hsa-miR-146b-5p CXXC4 0.402662509440885 0.837510937985092 -0.790601166401651 0.212175078787021 MirTarget;miRNATAP -0.659604627831056 7.80534193328136e-07 NA NA NA hsa-miR-154-3p CXXC4 0.170366170038505 0.546500133020447 -0.790601166401651 0.212175078787021 MirTarget -0.247180452917311 0.0330917280018445 NA NA NA hsa-miR-186-5p CXXC4 0.318786974828755 0.854127229389611 -0.790601166401651 0.212175078787021 mirMAP -0.346570718333162 0.0398335795961805 NA NA NA hsa-miR-190a-5p CXXC4 0.275531208543263 0.538488213403163 -0.790601166401651 0.212175078787021 MirTarget -0.269983375574972 0.0137344244362806 NA NA NA hsa-miR-21-5p CXXC4 0.14892088710744 0.970240620972125 -0.790601166401651 0.212175078787021 mirMAP -0.466047255361887 0.0216274497310072 NA NA NA hsa-miR-223-3p CXXC4 0.449245565106316 0.80968342565561 -0.790601166401651 0.212175078787021 MirTarget -0.325866664946908 9.07866389122905e-05 NA NA NA hsa-miR-338-5p CXXC4 -0.484769112400394 0.393961930708873 -0.790601166401651 0.212175078787021 MirTarget;miRNATAP -0.296863316569803 0.000581851346394819 NA NA NA hsa-miR-576-5p CXXC4 0.506413219377404 0.417187951364173 -0.790601166401651 0.212175078787021 mirMAP -0.315679038651768 0.00846447050193405 NA NA NA hsa-miR-582-5p CXXC4 0.399450205475138 0.581227478860085 -0.790601166401651 0.212175078787021 MirTarget;miRNATAP -0.402689420215908 0.00183306402952214 NA NA NA hsa-miR-589-5p CXXC4 0.448771545046784 0.722725226273464 -0.790601166401651 0.212175078787021 MirTarget;miRNATAP -0.627876279687671 0.000117797435675094 NA NA NA hsa-miR-590-3p CXXC4 0.27924475537686 0.591266699336619 -0.790601166401651 0.212175078787021 mirMAP -0.196482277438232 0.0499934109685908 NA NA NA hsa-miR-7-1-3p CXXC4 0.462485777435991 0.665899751398166 -0.790601166401651 0.212175078787021 mirMAP -0.359423110175008 0.00207272012054492 NA NA NA hsa-let-7a-3p CYBRD1 0.215598045625678 0.85543299203799 -0.533635089854676 0.666801938875854 mirMAP -0.532435077049832 2.32555312531524e-07 NA NA NA hsa-let-7a-3p CYP1B1 0.215598045625678 0.85543299203799 -0.235355060258456 0.727737799486738 mirMAP -0.944734186539498 1.71687162408751e-09 NA NA NA hsa-let-7a-3p DAAM1 0.215598045625678 0.85543299203799 0.170483432113034 0.857808092963577 MirTarget -0.142707913982381 0.00395938869466693 NA NA NA hsa-let-7g-3p DAAM1 0.489638373791484 0.62941522205833 0.170483432113034 0.857808092963577 MirTarget -0.122037825708611 0.00135747950994262 NA NA NA hsa-miR-125a-5p DAAM1 0.00183986061615293 0.999158100170883 0.170483432113034 0.857808092963577 MirTarget -0.154338230036723 0.00827558815103646 NA NA NA hsa-miR-130a-3p DAAM1 -0.0910074087716906 0.929098200371948 0.170483432113034 0.857808092963577 MirTarget;miRNATAP -0.186265972428335 4.80011426505858e-05 NA NA NA hsa-miR-130b-3p DAAM1 0.221667315324818 0.824660172394714 0.170483432113034 0.857808092963577 MirTarget;miRNATAP -0.190279619758573 3.00597553974218e-05 NA NA NA hsa-miR-130b-5p DAAM1 0.6472141103776 0.379096015222509 0.170483432113034 0.857808092963577 MirTarget -0.132266134140273 0.00224823100522212 NA NA NA hsa-miR-140-5p DAAM1 0.229213026275907 0.847330111738614 0.170483432113034 0.857808092963577 miRanda -0.202428791701825 0.00199244559179905 NA NA NA hsa-miR-142-3p DAAM1 0.154235241441331 0.946098054588918 0.170483432113034 0.857808092963577 miRanda -0.114139641450987 0.0017699000081446 NA NA NA hsa-miR-186-5p DAAM1 0.318786974828755 0.854127229389611 0.170483432113034 0.857808092963577 MirTarget;mirMAP -0.199851629594151 0.00143154535869659 NA NA NA hsa-miR-19a-3p DAAM1 0.206793507801887 0.844637784802316 0.170483432113034 0.857808092963577 miRNATAP -0.158631869740284 1.6104583445785e-05 NA NA NA hsa-miR-19b-3p DAAM1 0.0268530183621465 0.986656783046573 0.170483432113034 0.857808092963577 miRNATAP -0.219557475883144 4.94631687431852e-07 NA NA NA hsa-miR-21-5p DAAM1 0.14892088710744 0.970240620972125 0.170483432113034 0.857808092963577 miRNAWalker2_validate -0.158296277300235 0.0373379027869038 NA NA NA hsa-miR-212-3p DAAM1 0.0224067199236493 0.973232008101457 0.170483432113034 0.857808092963577 MirTarget;miRNATAP -0.131470848332999 0.0177816981301556 NA NA NA hsa-miR-27a-3p DAAM1 0.123902317731458 0.958804393510999 0.170483432113034 0.857808092963577 miRNATAP -0.323406617974826 4.61721444206115e-06 NA NA NA hsa-miR-29a-3p DAAM1 -0.0112747441028436 0.996977020481271 0.170483432113034 0.857808092963577 MirTarget;miRNATAP -0.305904615233183 1.00784743884738e-07 NA NA NA hsa-miR-29b-3p DAAM1 0.104016192263954 0.958988036765397 0.170483432113034 0.857808092963577 MirTarget;miRNATAP -0.210603350286755 1.48679676188051e-06 NA NA NA hsa-miR-32-3p DAAM1 0.568003960723004 0.13133163420273 0.170483432113034 0.857808092963577 mirMAP -0.123812750565078 0.000115356287668564 NA NA NA hsa-miR-32-5p DAAM1 0.0599326761911891 0.95297595159496 0.170483432113034 0.857808092963577 miRNATAP -0.139972847601259 0.0013313637746724 NA NA NA hsa-miR-335-3p DAAM1 0.244830745789441 0.884500191166311 0.170483432113034 0.857808092963577 mirMAP -0.105157100328169 0.0101064499662112 NA NA NA hsa-miR-335-5p DAAM1 0.0284895175847679 0.973380867832231 0.170483432113034 0.857808092963577 miRNAWalker2_validate;MirTarget;miRNATAP -0.158806516504925 9.35552512380998e-05 NA NA NA hsa-miR-34a-5p DAAM1 0.50188164870224 0.742034237185732 0.170483432113034 0.857808092963577 MirTarget;miRNATAP -0.117654387159418 0.0141404631792515 NA NA NA hsa-miR-362-3p DAAM1 0.721040238345347 0.0345881362485733 0.170483432113034 0.857808092963577 MirTarget;miRanda;miRNATAP -0.163521459566825 5.15503696888042e-06 NA NA NA hsa-miR-429 DAAM1 0.456485631615963 0.806240953400535 0.170483432113034 0.857808092963577 miRNATAP -0.101525246503503 0.00409320261536615 NA NA NA hsa-miR-452-5p DAAM1 0.0504626418153507 0.973874641360401 0.170483432113034 0.857808092963577 MirTarget -0.156517229568173 0.000254703292535222 NA NA NA hsa-miR-454-3p DAAM1 0.101514866328012 0.84354515825619 0.170483432113034 0.857808092963577 MirTarget;miRNATAP -0.166925285181881 0.00175859254883641 NA NA NA hsa-miR-548o-3p DAAM1 0.191447572716993 0.517725546183501 0.170483432113034 0.857808092963577 mirMAP -0.114031852333232 0.00528140836060873 NA NA NA hsa-miR-576-5p DAAM1 0.506413219377404 0.417187951364173 0.170483432113034 0.857808092963577 mirMAP -0.115323324429816 0.0102044098370995 NA NA NA hsa-miR-590-3p DAAM1 0.27924475537686 0.591266699336619 0.170483432113034 0.857808092963577 MirTarget;miRanda;mirMAP -0.128692560125035 0.000536645617060937 NA NA NA hsa-miR-92a-3p DAAM1 -0.0278830870766349 0.993247426671713 0.170483432113034 0.857808092963577 miRNATAP -0.192390375711452 2.38843044214745e-05 NA NA NA hsa-miR-141-5p DAAM2 0.354590233549885 0.867642456336402 -0.12319701515506 0.866241898438594 mirMAP -0.595158097965982 4.18174853054438e-16 NA NA NA hsa-miR-144-5p DAAM2 0.300173463942008 0.809668168233347 -0.12319701515506 0.866241898438594 mirMAP -0.131219343360829 0.0296094911382097 NA NA NA hsa-miR-182-5p DAAM2 0.10423849794055 0.973380614062244 -0.12319701515506 0.866241898438594 mirMAP -0.358619355576489 1.47192349985391e-06 NA NA NA hsa-miR-18a-5p DAAM2 0.498318455303918 0.612640919755849 -0.12319701515506 0.866241898438594 miRNAWalker2_validate -0.45873784011012 1.14446934648213e-14 NA NA NA hsa-miR-193a-3p DAAM2 0.247265785363731 0.654363581941635 -0.12319701515506 0.866241898438594 miRanda -0.337316870064459 2.37054530124182e-05 NA NA NA hsa-miR-1976 DAAM2 0.283448756688617 0.707004130216603 -0.12319701515506 0.866241898438594 mirMAP -0.532582609955771 3.92410177495442e-08 NA NA NA hsa-miR-19b-3p DAAM2 0.0268530183621465 0.986656783046573 -0.12319701515506 0.866241898438594 miRNAWalker2_validate -0.59050098355468 4.00033091353882e-13 NA NA NA hsa-miR-335-5p DAAM2 0.0284895175847679 0.973380867832231 -0.12319701515506 0.866241898438594 mirMAP -0.559642794983272 6.39421905069849e-14 NA NA NA hsa-miR-338-5p DAAM2 -0.484769112400394 0.393961930708873 -0.12319701515506 0.866241898438594 PITA;miRNATAP -0.133530391157355 0.0328662093058217 NA NA NA hsa-miR-339-5p DAAM2 0.300425087100668 0.712912847076787 -0.12319701515506 0.866241898438594 miRanda -0.547546638014412 8.84737831943075e-17 NA NA NA hsa-miR-361-3p DAAM2 0.285313945920493 0.847726816983045 -0.12319701515506 0.866241898438594 mirMAP -0.326968157486964 0.00993249663179331 NA NA NA hsa-miR-369-3p DAAM2 -0.116576891957687 0.83230082995912 -0.12319701515506 0.866241898438594 mirMAP -0.270121794606608 0.00211803000912154 NA NA NA hsa-miR-421 DAAM2 0.182032017078617 0.734704500318599 -0.12319701515506 0.866241898438594 PITA;miRanda -0.352816270039932 1.43302721484245e-05 NA NA NA hsa-miR-429 DAAM2 0.456485631615963 0.806240953400535 -0.12319701515506 0.866241898438594 miRNATAP -0.546180360150489 4.956191720599e-18 NA NA NA hsa-miR-589-3p DAAM2 0.835836305204965 0.0112001563801511 -0.12319701515506 0.866241898438594 mirMAP -0.350649199509711 7.79147478780687e-08 NA NA NA hsa-miR-590-3p DAAM2 0.27924475537686 0.591266699336619 -0.12319701515506 0.866241898438594 miRanda;mirMAP -0.575096394584599 6.27875129858233e-18 NA NA NA hsa-miR-592 DAAM2 0.177670083168544 0.856226890424691 -0.12319701515506 0.866241898438594 mirMAP -0.116291169902452 0.00126833211978792 NA NA NA hsa-let-7a-3p DAB1 0.215598045625678 0.85543299203799 -0.633572617808845 0.487442745115038 mirMAP -0.401261259763842 0.010978682769177 NA NA NA hsa-let-7a-3p DACT1 0.215598045625678 0.85543299203799 -0.397100600740143 0.641093197895659 MirTarget -0.453218462075073 1.83766330535189e-05 NA NA NA hsa-let-7a-3p DCBLD2 0.215598045625678 0.85543299203799 -0.180106604485904 0.868558137626114 miRNATAP -0.223208352674947 0.00960798150697693 NA NA NA hsa-let-7a-3p DENND1B 0.215598045625678 0.85543299203799 0.0959216830181278 0.823324241648453 mirMAP -0.117362676797518 0.0457205453175245 NA NA NA hsa-let-7a-3p DIO2 0.215598045625678 0.85543299203799 -0.0645843407895375 0.936657832021762 mirMAP -0.767366402841735 1.1954298663311e-12 NA NA NA hsa-miR-107 DKK1 0.0365118169251648 0.988364120226869 -2.12234217054464 0.0100076426738182 miRanda -1.06818126173056 0.00153469452605571 NA NA NA hsa-miR-16-2-3p DKK1 0.36717860153421 0.546850726070016 -2.12234217054464 0.0100076426738182 mirMAP -0.727503713353185 6.69781345912883e-05 NA NA NA hsa-miR-29a-3p DKK1 -0.0112747441028436 0.996977020481271 -2.12234217054464 0.0100076426738182 miRNAWalker2_validate;miRTarBase -0.537875938395831 0.0421374325156712 NA NA NA hsa-miR-590-3p DKK1 0.27924475537686 0.591266699336619 -2.12234217054464 0.0100076426738182 PITA;miRanda;mirMAP;miRNATAP -0.610011651992684 0.000246218084097269 NA NA NA hsa-miR-140-5p DKK2 0.229213026275907 0.847330111738614 -0.674433136505868 0.218463005299489 miRanda -0.482003975762883 0.0159070223976673 NA NA NA hsa-miR-142-3p DKK2 0.154235241441331 0.946098054588918 -0.674433136505868 0.218463005299489 miRanda -0.287731888562342 0.009784295223841 NA NA NA hsa-miR-193a-3p DKK2 0.247265785363731 0.654363581941635 -0.674433136505868 0.218463005299489 miRanda -0.337371222347827 0.00831119630033944 NA NA NA hsa-miR-221-3p DKK2 -0.0906940388127522 0.959121118272534 -0.674433136505868 0.218463005299489 miRNAWalker2_validate;miRTarBase -0.890094370168241 5.49123136277718e-08 NA NA NA hsa-miR-27a-3p DKK2 0.123902317731458 0.958804393510999 -0.674433136505868 0.218463005299489 miRNATAP -0.739748997527834 0.000647376426119641 NA NA NA hsa-miR-324-5p DKK2 0.50063248413014 0.537416710557032 -0.674433136505868 0.218463005299489 miRanda -0.685279382698123 1.13636449329792e-06 NA NA NA hsa-miR-335-5p DKK2 0.0284895175847679 0.973380867832231 -0.674433136505868 0.218463005299489 miRNAWalker2_validate -0.740205187739338 8.10644871869191e-10 NA NA NA hsa-miR-33a-3p DKK2 0.794543849238582 0.0105203072007922 -0.674433136505868 0.218463005299489 mirMAP -0.515970968191941 5.48116889312443e-06 NA NA NA hsa-miR-361-5p DKK2 0.138735309928775 0.941495130308343 -0.674433136505868 0.218463005299489 miRanda -0.986577790796155 1.46506525773545e-05 NA NA NA hsa-miR-374a-5p DKK2 0.343007247142618 0.766921280269271 -0.674433136505868 0.218463005299489 mirMAP -0.611865529730721 0.00163018467118069 NA NA NA hsa-miR-374b-5p DKK2 0.285682091626877 0.835698304799651 -0.674433136505868 0.218463005299489 mirMAP -0.895750662994789 1.36570969308441e-06 NA NA NA hsa-miR-486-5p DKK2 0.547739229538641 0.696404149927963 -0.674433136505868 0.218463005299489 miRanda;miRNATAP -0.393238090238234 1.33597603457378e-05 NA NA NA hsa-miR-576-5p DKK2 0.506413219377404 0.417187951364173 -0.674433136505868 0.218463005299489 mirMAP -0.819792337513585 4.7132301620388e-10 NA NA NA hsa-miR-590-3p DKK2 0.27924475537686 0.591266699336619 -0.674433136505868 0.218463005299489 miRanda;mirMAP;miRNATAP -0.756241189497093 3.14107282492043e-12 NA NA NA hsa-miR-590-5p DKK2 0.547819833829572 0.472735645776647 -0.674433136505868 0.218463005299489 miRanda -0.770227159553781 2.29895306202608e-11 NA NA NA hsa-miR-664a-3p DKK2 0.00395670341813492 0.996119749372709 -0.674433136505868 0.218463005299489 mirMAP -0.341738135905029 0.045695338686487 NA NA NA hsa-let-7a-3p DKK3 0.215598045625678 0.85543299203799 -0.319026130345842 0.811342924024388 MirTarget;miRNATAP -0.485719504384888 3.27144956762209e-10 NA NA NA hsa-let-7a-3p DNAJB5 0.215598045625678 0.85543299203799 -0.340213824390713 0.550988078317574 miRNATAP -0.530267204733672 2.04560349993529e-10 NA NA NA hsa-let-7a-3p DNALI1 0.215598045625678 0.85543299203799 -0.703260237015582 0.209174201742818 MirTarget;miRNATAP -0.350069086156492 0.0182219012037642 NA NA NA hsa-let-7a-3p DNM3 0.215598045625678 0.85543299203799 -0.386298840549263 0.382661166688683 MirTarget -0.456955952758579 3.32005123118831e-05 NA NA NA hsa-let-7a-3p DOK6 0.215598045625678 0.85543299203799 -0.303247888918563 0.429257190374566 mirMAP -0.540171536106734 5.88079721726253e-08 NA NA NA hsa-let-7a-3p DPY19L3 0.215598045625678 0.85543299203799 -0.1100665007832 0.898243788859333 mirMAP -0.115100508078479 0.0143264214122913 NA NA NA hsa-miR-221-3p DVL2 -0.0906940388127522 0.959121118272534 0.167559306568991 0.882789212674879 miRNAWalker2_validate -0.107215494752155 0.0034025469139885 21487968 MiR 221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2; We also suggest that miR-221 may control the migration of AIPC cells through DVL2 working as a key regulator in advanced CaP staging prostate cancer hsa-miR-21-5p DVL3 0.14892088710744 0.970240620972125 -0.0230454436789378 0.987936840377639 mirMAP -0.130513305195752 0.0002925771275384 NA NA NA hsa-let-7a-3p DZIP1 0.215598045625678 0.85543299203799 -0.503129824347212 0.323610967256899 MirTarget;mirMAP -0.593594243366321 1.92589260327048e-10 NA NA NA hsa-let-7a-3p EBF1 0.215598045625678 0.85543299203799 -0.391140555895117 0.326468203273832 mirMAP;miRNATAP -0.3820874200416 1.30124282598385e-05 NA NA NA hsa-let-7a-3p EBF3 0.215598045625678 0.85543299203799 -0.305536946328112 0.474858898992906 MirTarget;miRNATAP -0.559054382060662 4.34553391173394e-07 NA NA NA hsa-let-7a-3p EDIL3 0.215598045625678 0.85543299203799 -0.212629115183296 0.772510282152206 MirTarget -0.784545268016555 1.49841720471435e-11 NA NA NA hsa-let-7a-3p EEA1 0.215598045625678 0.85543299203799 0.24934684615492 0.839297761872054 MirTarget;miRNATAP -0.12586720007566 0.00519045184768883 NA NA NA hsa-let-7a-3p EFNA5 0.215598045625678 0.85543299203799 -0.503344091670042 0.404435726866389 miRNATAP -0.40543498468815 0.00989547054421855 NA NA NA hsa-let-7a-3p EGFL6 0.215598045625678 0.85543299203799 0.708359903392235 0.165495385154925 MirTarget -0.336133356278777 0.0024112159471566 NA NA NA hsa-let-7a-3p ELAVL2 0.215598045625678 0.85543299203799 -1.74379200630931 0.038986832008634 MirTarget;mirMAP;miRNATAP -0.421324563581095 0.041360048720939 NA NA NA hsa-let-7a-3p ELK3 0.215598045625678 0.85543299203799 -0.12356335388444 0.891000867583835 MirTarget -0.383269325024311 1.07211664536951e-10 NA NA NA hsa-let-7a-3p ELL2 0.215598045625678 0.85543299203799 -0.133723124649913 0.90295952366464 mirMAP -0.133460953353326 0.0107471630920249 NA NA NA hsa-let-7a-3p ELOVL2 0.215598045625678 0.85543299203799 -0.592177334336658 0.339314547633404 miRNATAP -0.487850080991159 4.6881192534931e-05 NA NA NA hsa-let-7a-3p EML1 0.215598045625678 0.85543299203799 -0.489697904001217 0.465519033799685 MirTarget -0.561713294471944 1.32243125137611e-08 NA NA NA hsa-let-7a-3p ENTPD1 0.215598045625678 0.85543299203799 -0.0139432820651209 0.991366497034083 mirMAP -0.272873749057761 1.35044519625476e-08 NA NA NA hsa-miR-106b-5p EP300 0.297128724729338 0.86929444354075 0.275785871935124 0.858275138267876 miRNATAP -0.130709049655062 0.000960073772533261 NA NA NA hsa-miR-26b-5p EP300 0.0245931278499594 0.990377966314923 0.275785871935124 0.858275138267876 miRNAWalker2_validate;miRNATAP -0.122462053179979 0.0081599533716202 NA NA NA hsa-miR-339-5p EP300 0.300425087100668 0.712912847076787 0.275785871935124 0.858275138267876 miRanda -0.107604978422911 0.000130192205849388 NA NA NA hsa-miR-369-3p EP300 -0.116576891957687 0.83230082995912 0.275785871935124 0.858275138267876 MirTarget;PITA;miRNATAP -0.151763068163101 1.43595410012867e-05 NA NA NA hsa-let-7a-3p EPHA3 0.215598045625678 0.85543299203799 -0.414127932941873 0.401053433209847 mirMAP;miRNATAP -0.781966830350823 7.57068361826318e-12 NA NA NA hsa-let-7a-3p EPHA7 0.215598045625678 0.85543299203799 -0.691678823664649 0.272312186632263 mirMAP;miRNATAP -0.583498078595759 0.000948844438079671 NA NA NA hsa-let-7a-3p ESR1 0.215598045625678 0.85543299203799 0.351759595516062 0.511047607903369 mirMAP -0.597157105347607 8.17321648824779e-07 20535543;21826373 Let 7 family miRNAs regulate estrogen receptor alpha signaling in estrogen receptor positive breast cancer; Next we performed bioinformatics analysis and found that let-7 miRNA sequences match sequence in the 3'-UTR of estrogen receptor alpha ER-α suggesting ER-α may be a target of let-7 which was further confirmed by a number of experimental assays including luciferase assay protein expression and mRNA expression;let 7 microRNAs induce tamoxifen sensitivity by downregulation of estrogen receptor α signaling in breast cancer ; breast cancer;breast cancer hsa-let-7a-3p EVI2A 0.215598045625678 0.85543299203799 0.240019493930813 0.677362775066728 MirTarget -0.628283415514803 8.50786126437153e-10 NA NA NA hsa-let-7a-3p EYA4 0.215598045625678 0.85543299203799 0.129192183733466 0.873466312755923 miRNATAP -0.533736884249879 0.000366577785470679 NA NA NA hsa-let-7a-3p FAM126A 0.215598045625678 0.85543299203799 -0.376681075740571 0.594540427753259 MirTarget -0.422440620275407 1.00135778477825e-06 NA NA NA hsa-let-7a-3p FAM19A1 0.215598045625678 0.85543299203799 0.304555621754296 0.683251261802879 miRNATAP -0.666520886646331 2.84060277095394e-06 NA NA NA hsa-let-7a-3p FAM19A2 0.215598045625678 0.85543299203799 -0.419812597696015 0.510098194691055 miRNATAP -0.313227353574939 0.001985989612733 NA NA NA hsa-let-7a-3p FAM19A5 0.215598045625678 0.85543299203799 -0.374615756809682 0.485653884800769 MirTarget;miRNATAP -0.561865619906762 2.60426764325746e-08 NA NA NA hsa-let-7a-3p FAM26E 0.215598045625678 0.85543299203799 -0.233297440102082 0.646359179956996 mirMAP -0.636326700290193 3.77046985871128e-10 NA NA NA hsa-let-7a-3p FAM63B 0.215598045625678 0.85543299203799 0.0666662711538257 0.905388316332803 mirMAP -0.314260318760196 1.07206454797211e-06 NA NA NA hsa-let-7a-3p FAT3 0.215598045625678 0.85543299203799 -0.454780518378139 0.437247426039174 miRNATAP -0.659973336881943 1.02820078969436e-07 NA NA NA hsa-let-7a-3p FBN1 0.215598045625678 0.85543299203799 -0.297293354351475 0.842153070480905 mirMAP -0.761447344194889 3.2096333395523e-11 NA NA NA hsa-let-7a-3p FBXO32 0.215598045625678 0.85543299203799 -0.221230497026003 0.815725450266166 mirMAP -0.247347905616606 0.000598561589620743 NA NA NA hsa-miR-374a-5p FBXW11 0.343007247142618 0.766921280269271 -0.0591555286850083 0.962033974207803 mirMAP -0.120232748570681 0.000160498273248043 NA NA NA hsa-miR-505-3p FBXW11 0.469094267152606 0.690382680489577 -0.0591555286850083 0.962033974207803 mirMAP -0.103431273126737 0.000111709512682406 NA NA NA hsa-let-7a-3p FGF12 0.215598045625678 0.85543299203799 0.0733567813264711 0.900820415244381 MirTarget -0.31967445902099 0.000591732965496754 NA NA NA hsa-let-7a-3p FGF13 0.215598045625678 0.85543299203799 -0.520694054373788 0.23998224203533 MirTarget;miRNATAP -0.413074100574929 0.00107885043966615 NA NA NA hsa-let-7a-3p FGF2 0.215598045625678 0.85543299203799 -0.0373403819942286 0.94566315631076 mirMAP -0.508812543963832 9.06476874891136e-06 NA NA NA hsa-let-7a-3p FGF7 0.215598045625678 0.85543299203799 -0.117105484614997 0.84810083077581 MirTarget;miRNATAP -0.683797140192053 9.84850919759302e-09 NA NA NA hsa-let-7a-3p FIGN 0.215598045625678 0.85543299203799 -0.0388610222027246 0.954072601685295 mirMAP -0.73644789469253 3.78173302136355e-09 NA NA NA hsa-let-7a-3p FKBP7 0.215598045625678 0.85543299203799 -0.151993810124171 0.831322192466361 mirMAP -0.211179673926529 4.78439504428086e-05 NA NA NA hsa-let-7a-3p FLRT2 0.215598045625678 0.85543299203799 0.0690064791871656 0.908778184530433 mirMAP -0.741676555845987 2.5148093772764e-09 NA NA NA hsa-let-7a-3p FNDC3B 0.215598045625678 0.85543299203799 0.00675899428179783 0.996385907883701 MirTarget -0.124438134559055 0.00405372828812947 NA NA NA hsa-miR-19b-3p FOSL1 0.0268530183621465 0.986656783046573 -0.108614991972286 0.9054743032267 MirTarget -0.219671781440311 0.0306365531890092 NA NA NA hsa-let-7a-3p FOXP2 0.215598045625678 0.85543299203799 0.0754960616638315 0.914208560979612 MirTarget;mirMAP -0.870923086669036 1.12380632065085e-05 NA NA NA hsa-miR-22-3p FRAT2 -0.0592693913158495 0.986564295498741 0.194463727237224 0.869741180023171 miRNAWalker2_validate;MirTarget;miRNATAP -0.190195907315066 0.00287842550547643 NA NA NA hsa-let-7a-3p FREM2 0.215598045625678 0.85543299203799 -2.56275326585462 0.00367674728786552 MirTarget;mirMAP -0.524865452368208 0.0458017271110444 NA NA NA hsa-let-7a-3p FRMD4A 0.215598045625678 0.85543299203799 0.0244637384296924 0.977042729626843 miRNATAP -0.170556861033641 0.00506573278096563 NA NA NA hsa-let-7a-3p FRMD6 0.215598045625678 0.85543299203799 -0.398976049319802 0.646697821298941 MirTarget;mirMAP -0.63646027716623 8.36743043619176e-11 NA NA NA hsa-let-7a-3p FSTL1 0.215598045625678 0.85543299203799 -0.408448918740493 0.811819716827988 mirMAP -0.523542668772006 3.82904285549215e-11 NA NA NA hsa-let-7a-3p FYB 0.215598045625678 0.85543299203799 0.536425169557948 0.488519472214804 MirTarget -0.485136734451741 9.05551305437503e-06 NA NA NA hsa-miR-1275 FZD1 0.831342050607647 0.0803795852164229 0.0511757191873938 0.959081690359455 MirTarget -0.11752493679076 0.000375152206570806 NA NA NA hsa-miR-146a-5p FZD1 0.581292803346902 0.736851349367572 0.0511757191873938 0.959081690359455 MirTarget -0.18270145041992 3.3371303321675e-05 NA NA NA hsa-miR-148b-5p FZD1 0.236618793990305 0.43925706879726 0.0511757191873938 0.959081690359455 MirTarget -0.276963845962678 3.19703916121763e-09 NA NA NA hsa-miR-186-5p FZD1 0.318786974828755 0.854127229389611 0.0511757191873938 0.959081690359455 mirMAP -0.442243854107384 6.58112949339573e-10 NA NA NA hsa-miR-192-5p FZD1 0.117345487848226 0.972927287653136 0.0511757191873938 0.959081690359455 miRNAWalker2_validate -0.29249446475231 1.60822915399963e-13 NA NA NA hsa-miR-200a-5p FZD1 0.671005453811576 0.78126028567661 0.0511757191873938 0.959081690359455 MirTarget -0.283079971493201 1.53230997569097e-09 NA NA NA hsa-miR-200b-5p FZD1 0.502275384207407 0.722255155236926 0.0511757191873938 0.959081690359455 MirTarget -0.337269077999376 1.11302413325129e-13 NA NA NA hsa-miR-29a-3p FZD1 -0.0112747441028436 0.996977020481271 0.0511757191873938 0.959081690359455 mirMAP -0.413500580447596 6.69744408607844e-10 NA NA NA hsa-miR-29b-3p FZD1 0.104016192263954 0.958988036765397 0.0511757191873938 0.959081690359455 mirMAP -0.389589850217655 3.11370022041214e-15 NA NA NA hsa-miR-335-5p FZD1 0.0284895175847679 0.973380867832231 0.0511757191873938 0.959081690359455 miRNAWalker2_validate -0.287938175924094 7.09583918605026e-10 NA NA NA hsa-miR-577 FZD1 1.06238199218774 0.326056761787754 0.0511757191873938 0.959081690359455 MirTarget;PITA -0.193897696514949 8.76701831976043e-14 NA NA NA hsa-miR-590-3p FZD1 0.27924475537686 0.591266699336619 0.0511757191873938 0.959081690359455 miRanda -0.291958862049538 4.01010434726308e-12 NA NA NA hsa-miR-93-3p FZD1 0.438355548962673 0.549902689385444 0.0511757191873938 0.959081690359455 MirTarget -0.331297673037746 1.33030931304845e-11 NA NA NA hsa-miR-140-3p FZD10 0.369894078407762 0.864762211761538 -0.672999650470658 0.343524502785401 miRNATAP -0.874493581410679 0.0082353652076572 NA NA NA hsa-miR-15b-5p FZD10 0.272614787130879 0.870965418321879 -0.672999650470658 0.343524502785401 miRNATAP -0.760641203413187 0.000336442978733665 NA NA NA hsa-miR-16-5p FZD10 -0.0135949734723564 0.994476223855607 -0.672999650470658 0.343524502785401 miRNATAP -0.661414593664301 0.00183454732995892 NA NA NA hsa-miR-92b-3p FZD10 0.569866984318693 0.689321861489778 -0.672999650470658 0.343524502785401 miRNATAP -0.846940680279183 2.00455998708371e-06 NA NA NA hsa-miR-125b-2-3p FZD3 0.0782435784241886 0.894638061041299 0.709666581031872 0.308168084051882 mirMAP -0.107169205716175 0.0284593276783988 NA NA NA hsa-miR-143-3p FZD3 -0.371591944134732 0.927341352649584 0.709666581031872 0.308168084051882 mirMAP -0.184689304004733 0.0267817770161185 NA NA NA hsa-miR-181c-5p FZD3 -0.0429518916606941 0.969159991881861 0.709666581031872 0.308168084051882 mirMAP -0.198366910964517 0.0100327085674848 NA NA NA hsa-miR-23b-3p FZD3 0.108222548187042 0.961352920317635 0.709666581031872 0.308168084051882 MirTarget -0.293019765420183 0.0290155626741524 NA NA NA hsa-miR-30a-3p FZD3 -0.250338313897394 0.917094926793447 0.709666581031872 0.308168084051882 mirMAP -0.502888110666901 2.05499958948805e-07 NA NA NA hsa-miR-30a-5p FZD3 -0.219472325612347 0.933954023293815 0.709666581031872 0.308168084051882 MirTarget;miRNATAP -0.727481268646512 1.34518538564639e-11 NA NA NA hsa-miR-30e-5p FZD3 0.0657075181380993 0.979684509181942 0.709666581031872 0.308168084051882 MirTarget -0.305355951237959 0.00776468229563295 NA NA NA hsa-miR-664a-3p FZD3 0.00395670341813492 0.996119749372709 0.709666581031872 0.308168084051882 MirTarget;mirMAP -0.204255831645275 0.0269940807786287 NA NA NA hsa-let-7a-3p FZD4 0.215598045625678 0.85543299203799 -0.0878618904726611 0.926402581549652 mirMAP -0.24235415493525 1.98163871311651e-05 NA NA NA hsa-let-7d-5p FZD4 0.139747701175051 0.934164162708487 -0.0878618904726611 0.926402581549652 MirTarget;miRNATAP -0.378744975720612 5.05342251895716e-06 NA NA NA hsa-let-7f-1-3p FZD4 0.31101436822914 0.693407210545374 -0.0878618904726611 0.926402581549652 mirMAP -0.331002599507533 1.97156389472645e-05 NA NA NA hsa-let-7f-5p FZD4 -0.0487899170347212 0.987280455481632 -0.0878618904726611 0.926402581549652 MirTarget;miRNATAP -0.240219811220551 0.00274263197108385 NA NA NA hsa-let-7g-3p FZD4 0.489638373791484 0.62941522205833 -0.0878618904726611 0.926402581549652 MirTarget;miRNATAP -0.250526051982766 5.7607717020182e-09 NA NA NA hsa-let-7g-5p FZD4 0.200947212961156 0.922992045181955 -0.0878618904726611 0.926402581549652 MirTarget;miRNATAP -0.445951284220326 1.95048404448625e-08 NA NA NA hsa-miR-106b-5p FZD4 0.297128724729338 0.86929444354075 -0.0878618904726611 0.926402581549652 miRNATAP -0.462968844683632 9.22394261685133e-17 NA NA NA hsa-miR-107 FZD4 0.0365118169251648 0.988364120226869 -0.0878618904726611 0.926402581549652 miRNATAP -0.292893621156472 0.000771321721536902 NA NA NA hsa-miR-10a-5p FZD4 -0.074058572068596 0.983770933356405 -0.0878618904726611 0.926402581549652 MirTarget -0.280584207335698 6.27494988897258e-09 NA NA NA hsa-miR-130b-3p FZD4 0.221667315324818 0.824660172394714 -0.0878618904726611 0.926402581549652 mirMAP -0.412310564071406 1.63661208275803e-16 NA NA NA hsa-miR-141-3p FZD4 0.31994058840327 0.87774106909065 -0.0878618904726611 0.926402581549652 TargetScan -0.349055161798277 1.71327499085363e-17 NA NA NA hsa-miR-15a-5p FZD4 0.0674049094129137 0.964835434214122 -0.0878618904726611 0.926402581549652 MirTarget -0.39947651989731 2.8153629018267e-11 NA NA NA hsa-miR-15b-5p FZD4 0.272614787130879 0.870965418321879 -0.0878618904726611 0.926402581549652 MirTarget -0.322385382369299 1.66717339874602e-08 NA NA NA hsa-miR-16-5p FZD4 -0.0135949734723564 0.994476223855607 -0.0878618904726611 0.926402581549652 MirTarget -0.38640102816812 5.05353596618766e-12 NA NA NA hsa-miR-17-3p FZD4 -0.100221625453136 0.960113387014848 -0.0878618904726611 0.926402581549652 MirTarget -0.344296092854496 1.16384737811129e-11 NA NA NA hsa-miR-17-5p FZD4 0.175448849583061 0.934544015912731 -0.0878618904726611 0.926402581549652 TargetScan -0.385278735283471 2.4212409069261e-20 NA NA NA hsa-miR-185-5p FZD4 0.294432218239008 0.820591478398594 -0.0878618904726611 0.926402581549652 MirTarget -0.25931120793545 0.000355854644349803 NA NA NA hsa-miR-186-5p FZD4 0.318786974828755 0.854127229389611 -0.0878618904726611 0.926402581549652 mirMAP -0.394785495166536 2.71490669306833e-08 NA NA NA hsa-miR-192-5p FZD4 0.117345487848226 0.972927287653136 -0.0878618904726611 0.926402581549652 miRNAWalker2_validate;mirMAP -0.315929034898543 2.09067678228179e-16 NA NA NA hsa-miR-200b-3p FZD4 0.426401948379212 0.863957108574195 -0.0878618904726611 0.926402581549652 mirMAP -0.330735975746675 9.2070049888302e-12 NA NA NA hsa-miR-200c-3p FZD4 0.437282635857873 0.887118598436407 -0.0878618904726611 0.926402581549652 mirMAP -0.389224630715533 2.0181642631006e-15 NA NA NA hsa-miR-20a-5p FZD4 0.179153323927949 0.928118119139752 -0.0878618904726611 0.926402581549652 miRNATAP -0.326109320648211 1.14866355828259e-14 NA NA NA hsa-miR-24-3p FZD4 0.0484778924256641 0.985274054814493 -0.0878618904726611 0.926402581549652 miRNAWalker2_validate -0.401582174051184 0.000106106750154132 NA NA NA hsa-miR-25-3p FZD4 0.457540448732733 0.878574066837636 -0.0878618904726611 0.926402581549652 mirMAP -0.454137375975653 1.0437216784944e-10 NA NA NA hsa-miR-27a-3p FZD4 0.123902317731458 0.958804393510999 -0.0878618904726611 0.926402581549652 miRNATAP -0.369388638057351 6.5207729341799e-06 NA NA NA hsa-miR-301a-3p FZD4 0.10531251190177 0.831686745977346 -0.0878618904726611 0.926402581549652 mirMAP -0.238068583095689 6.48876495696042e-08 NA NA NA hsa-miR-32-3p FZD4 0.568003960723004 0.13133163420273 -0.0878618904726611 0.926402581549652 mirMAP -0.26908806822694 3.5631981260887e-14 NA NA NA hsa-miR-32-5p FZD4 0.0599326761911891 0.95297595159496 -0.0878618904726611 0.926402581549652 mirMAP -0.272773834348837 3.46453179321418e-08 NA NA NA hsa-miR-324-3p FZD4 0.424387380347173 0.661528309116338 -0.0878618904726611 0.926402581549652 miRNATAP -0.307177917489889 7.75266283928872e-07 NA NA NA hsa-miR-33a-3p FZD4 0.794543849238582 0.0105203072007922 -0.0878618904726611 0.926402581549652 mirMAP -0.211644634278252 9.28824887249447e-07 NA NA NA hsa-miR-361-5p FZD4 0.138735309928775 0.941495130308343 -0.0878618904726611 0.926402581549652 mirMAP -0.367474368087195 2.36770477912264e-05 NA NA NA hsa-miR-375 FZD4 0.690952835064579 0.831716365337669 -0.0878618904726611 0.926402581549652 miRNAWalker2_validate;miRNATAP -0.13178579107507 5.27238238037549e-05 NA NA NA hsa-miR-377-3p FZD4 0.0435868040110953 0.893514136702459 -0.0878618904726611 0.926402581549652 MirTarget -0.105713850802793 0.0214448971848054 24166498 Finally we identified FZD4 a gene important for epithelial-to-mesenchymal transition in PCa as a target of miR-377 prostate cancer hsa-miR-424-5p FZD4 -0.247080963500745 0.870154571783569 -0.0878618904726611 0.926402581549652 MirTarget -0.144945609072968 0.000796475929538292 NA NA NA hsa-miR-429 FZD4 0.456485631615963 0.806240953400535 -0.0878618904726611 0.926402581549652 mirMAP -0.302376022892235 5.25763775406751e-15 NA NA NA hsa-miR-452-5p FZD4 0.0504626418153507 0.973874641360401 -0.0878618904726611 0.926402581549652 miRNATAP -0.165583048875209 0.000875694384307184 NA NA NA hsa-miR-454-3p FZD4 0.101514866328012 0.84354515825619 -0.0878618904726611 0.926402581549652 mirMAP -0.332875145499982 3.69563381519303e-08 NA NA NA hsa-miR-455-3p FZD4 0.35634168171146 0.824635754440662 -0.0878618904726611 0.926402581549652 mirMAP -0.167658801626423 0.000105569165309893 NA NA NA hsa-miR-484 FZD4 0.17997720269125 0.886333755572375 -0.0878618904726611 0.926402581549652 PITA -0.36169259047709 9.83073480624767e-09 NA NA NA hsa-miR-505-5p FZD4 0.555858818875454 0.317679205488749 -0.0878618904726611 0.926402581549652 MirTarget -0.214180288854279 2.59147925946339e-05 NA NA NA hsa-miR-548o-3p FZD4 0.191447572716993 0.517725546183501 -0.0878618904726611 0.926402581549652 MirTarget;mirMAP -0.186630956887194 7.1182737756345e-05 NA NA NA hsa-miR-576-5p FZD4 0.506413219377404 0.417187951364173 -0.0878618904726611 0.926402581549652 mirMAP -0.294023395404864 5.75088811667438e-09 NA NA NA hsa-miR-589-3p FZD4 0.835836305204965 0.0112001563801511 -0.0878618904726611 0.926402581549652 mirMAP -0.20050840471974 3.94945449551434e-07 NA NA NA hsa-miR-590-3p FZD4 0.27924475537686 0.591266699336619 -0.0878618904726611 0.926402581549652 miRanda;mirMAP;miRNATAP -0.316895774015859 8.83616028088734e-15 NA NA NA hsa-miR-590-5p FZD4 0.547819833829572 0.472735645776647 -0.0878618904726611 0.926402581549652 mirMAP -0.364461844197489 1.17961583838464e-17 NA NA NA hsa-miR-629-3p FZD4 0.49540274581201 0.333967382214383 -0.0878618904726611 0.926402581549652 miRNATAP -0.215719580317411 1.1650369483956e-07 NA NA NA hsa-miR-7-1-3p FZD4 0.462485777435991 0.665899751398166 -0.0878618904726611 0.926402581549652 mirMAP -0.246259494536549 7.66825345676451e-07 NA NA NA hsa-miR-92a-3p FZD4 -0.0278830870766349 0.993247426671713 -0.0878618904726611 0.926402581549652 mirMAP -0.444671994040866 1.67578436949747e-19 NA NA NA hsa-miR-940 FZD4 0.225788347550697 0.680055767105815 -0.0878618904726611 0.926402581549652 miRNATAP -0.208968947832091 6.88297555159904e-09 NA NA NA hsa-miR-98-5p FZD4 0.168162186023221 0.898802461503524 -0.0878618904726611 0.926402581549652 MirTarget -0.36892820953079 8.02707007553463e-08 NA NA NA hsa-miR-100-5p FZD5 -0.0230258429671419 0.992818348620337 0.365944021258739 0.803644920287013 MirTarget;miRNATAP -0.161373951724948 1.91022558437002e-07 NA NA NA hsa-miR-30a-3p FZD5 -0.250338313897394 0.917094926793447 0.365944021258739 0.803644920287013 mirMAP -0.176897321104786 0.000788197434899611 NA NA NA hsa-miR-99a-5p FZD5 0.0816417843399977 0.957743991295436 0.365944021258739 0.803644920287013 MirTarget;miRNATAP -0.138923742595564 1.05411725584288e-08 NA NA NA hsa-miR-99b-5p FZD5 -0.0468672968421853 0.987817055855752 0.365944021258739 0.803644920287013 MirTarget;miRNATAP -0.182676788932937 0.00135694110088436 NA NA NA hsa-let-7a-3p FZD6 0.215598045625678 0.85543299203799 0.116202458329265 0.917959139627305 MirTarget;mirMAP -0.115231878920242 0.0233074142014958 NA NA NA hsa-miR-126-5p FZD6 -0.0815213541035842 0.956637332055184 0.116202458329265 0.917959139627305 mirMAP;miRNATAP -0.203343882862267 0.000514833756074637 NA NA NA hsa-miR-130a-3p FZD6 -0.0910074087716906 0.929098200371948 0.116202458329265 0.917959139627305 MirTarget -0.151442534371088 0.00132131645480315 NA NA NA hsa-miR-140-5p FZD6 0.229213026275907 0.847330111738614 0.116202458329265 0.917959139627305 MirTarget;miRanda -0.277103508018634 2.94288580107927e-05 NA NA NA hsa-miR-342-3p FZD6 0.371626144515113 0.77313668985267 0.116202458329265 0.917959139627305 miRanda -0.155141338349412 0.000772377404667349 NA NA NA hsa-miR-377-3p FZD6 0.0435868040110953 0.893514136702459 0.116202458329265 0.917959139627305 MirTarget -0.125596119648936 0.0018297319558545 NA NA NA hsa-miR-654-3p FZD6 -0.0699248385448756 0.946997748280674 0.116202458329265 0.917959139627305 MirTarget -0.18305400928971 0.000261587621170951 NA NA NA hsa-miR-655-3p FZD6 -0.225525683904601 0.432294495359121 0.116202458329265 0.917959139627305 MirTarget -0.143568409731071 0.00234398104814069 NA NA NA hsa-miR-106b-5p FZD7 0.297128724729338 0.86929444354075 -0.141758736826612 0.887530668345864 miRNATAP -0.310495407892443 0.000271077453576642 NA NA NA hsa-miR-130b-5p FZD7 0.6472141103776 0.379096015222509 -0.141758736826612 0.887530668345864 mirMAP -0.392592588060961 2.5891496920303e-08 NA NA NA hsa-miR-142-3p FZD7 0.154235241441331 0.946098054588918 -0.141758736826612 0.887530668345864 miRanda -0.218286508217908 0.000324756034389622 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7; In addition we demonstrated that FZD7 was a direct target of miR-142-3p by dual luciferase assay and Western blot analysis; Overexpression of FZD7 expression was able to reverse the inhibitory effects induced by miR-142-3p cervical and endocervical cancer hsa-miR-142-5p FZD7 0.118920788314118 0.929665277963083 -0.141758736826612 0.887530668345864 MirTarget;PITA;miRNATAP -0.14088768800568 0.0369870779914508 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7 cervical and endocervical cancer hsa-miR-186-5p FZD7 0.318786974828755 0.854127229389611 -0.141758736826612 0.887530668345864 mirMAP -0.348883372385438 0.000843840090060864 NA NA NA hsa-miR-192-5p FZD7 0.117345487848226 0.972927287653136 -0.141758736826612 0.887530668345864 miRNAWalker2_validate -0.249111583108782 2.02554742642096e-05 NA NA NA hsa-miR-20a-5p FZD7 0.179153323927949 0.928118119139752 -0.141758736826612 0.887530668345864 miRNATAP -0.188776672406327 0.00334789787042153 NA NA NA hsa-miR-215-5p FZD7 0.142648109361913 0.94480931294964 -0.141758736826612 0.887530668345864 miRNAWalker2_validate -0.145178549109679 0.000105418654498185 NA NA NA hsa-miR-27a-3p FZD7 0.123902317731458 0.958804393510999 -0.141758736826612 0.887530668345864 MirTarget;miRNATAP -0.387909908210953 0.00113960545475631 24018051 Moreover up-regulation of miR-27a did not decrease the FZD7 mRNA level but significantly reduce its protein expression in BEL/5-FU cells; It was also confirmed that reduction of FZD7 by RNA interference induced inhibitory effects on the expression of MDR1/P-glycoprotein and β-catenin similar to miR-27a liver cancer hsa-miR-33a-3p FZD7 0.794543849238582 0.0105203072007922 -0.141758736826612 0.887530668345864 mirMAP;miRNATAP -0.270382002512775 1.50067738257573e-05 NA NA NA hsa-miR-429 FZD7 0.456485631615963 0.806240953400535 -0.141758736826612 0.887530668345864 miRanda;miRNATAP -0.265085451054369 5.24631037789406e-06 NA NA NA hsa-miR-486-5p FZD7 0.547739229538641 0.696404149927963 -0.141758736826612 0.887530668345864 miRanda -0.145351513590878 0.00377760791344002 NA NA NA hsa-miR-491-5p FZD7 0.585652105321328 0.0452620602586908 -0.141758736826612 0.887530668345864 miRanda -0.137807054573303 0.0398001043311757 NA NA NA hsa-miR-542-3p FZD7 -0.188168046511374 0.909252939431573 -0.141758736826612 0.887530668345864 miRanda -0.192024610858777 0.035228354784322 NA NA NA hsa-miR-590-3p FZD7 0.27924475537686 0.591266699336619 -0.141758736826612 0.887530668345864 miRanda -0.262788794497016 2.00216517482804e-05 NA NA NA hsa-miR-324-5p FZD8 0.50063248413014 0.537416710557032 -0.086302335641717 0.9121821294711 miRanda -0.304244224471374 2.30626517977631e-05 NA NA NA hsa-miR-335-5p FZD8 0.0284895175847679 0.973380867832231 -0.086302335641717 0.9121821294711 miRNAWalker2_validate -0.20789770534199 0.00096266610107808 NA NA NA hsa-miR-362-3p FZD8 0.721040238345347 0.0345881362485733 -0.086302335641717 0.9121821294711 miRanda -0.198500222894791 0.000375690442920201 NA NA NA hsa-miR-374b-5p FZD8 0.285682091626877 0.835698304799651 -0.086302335641717 0.9121821294711 miRNAWalker2_validate -0.269005251180704 0.00494097809194219 NA NA NA hsa-miR-375 FZD8 0.690952835064579 0.831716365337669 -0.086302335641717 0.9121821294711 miRNAWalker2_validate -0.144781056445186 0.000895163191296766 27276676 MicroRNA 375 suppresses human colorectal cancer metastasis by targeting Frizzled 8; Therefore we concluded that miR-375 functions as a tumor-suppressive microRNA by directly acting upon FZD8 which may serve as a new therapeutic target to inhibit tumor metastasis in CRC metastasis colorectal cancer hsa-miR-429 FZD8 0.456485631615963 0.806240953400535 -0.086302335641717 0.9121821294711 miRanda -0.252955344596221 2.43003733030416e-06 NA NA NA hsa-miR-590-3p FZD8 0.27924475537686 0.591266699336619 -0.086302335641717 0.9121821294711 miRanda -0.362794235468147 5.60279970711268e-11 NA NA NA hsa-miR-7-1-3p FZD8 0.462485777435991 0.665899751398166 -0.086302335641717 0.9121821294711 MirTarget -0.340287338649772 2.58862272082261e-07 NA NA NA hsa-let-7a-3p GABRA2 0.215598045625678 0.85543299203799 -0.626004553149158 0.372444656703966 mirMAP -0.768036889517321 0.00019493247375222 NA NA NA hsa-let-7a-3p GABRB3 0.215598045625678 0.85543299203799 -0.859259838521308 0.32235041858673 miRNATAP -0.922094274557611 3.47429664749129e-05 NA NA NA hsa-let-7a-3p GAS1 0.215598045625678 0.85543299203799 -0.747039642017699 0.28814577064886 miRNATAP -0.868132357338781 1.46415340470527e-07 NA NA NA hsa-let-7a-3p GATA3 0.215598045625678 0.85543299203799 0.167450735878594 0.63102161495582 MirTarget;miRNATAP -0.351252012305017 0.000348715281871325 NA NA NA hsa-let-7a-3p GDF11 0.215598045625678 0.85543299203799 -0.0794611673127577 0.921306345479385 mirMAP -0.181806016899018 0.00389520324447588 NA NA NA hsa-let-7a-3p GFRA1 0.215598045625678 0.85543299203799 -0.221689389780887 0.708096539096584 mirMAP;miRNATAP -0.896353737518595 9.80548282608087e-08 NA NA NA hsa-let-7a-3p GFRA2 0.215598045625678 0.85543299203799 0.0430907188069158 0.941284445122991 mirMAP -0.529804420559979 6.60536105671701e-05 NA NA NA hsa-let-7a-3p GJC1 0.215598045625678 0.85543299203799 -0.384163797922045 0.499829023522583 mirMAP -0.443236433200303 1.00547975956862e-08 NA NA NA hsa-let-7a-3p GLIS3 0.215598045625678 0.85543299203799 -0.600539143694574 0.270454570548931 mirMAP -0.383101414513831 0.000628452291859086 NA NA NA hsa-let-7a-3p GNB4 0.215598045625678 0.85543299203799 -0.150575910970852 0.870906281992549 MirTarget -0.527462288702162 1.32800230080668e-10 NA NA NA hsa-let-7a-3p GPC6 0.215598045625678 0.85543299203799 -0.285741828522374 0.705382785699365 MirTarget -0.681584958240194 9.19876124078797e-11 NA NA NA hsa-let-7a-3p GPM6B 0.215598045625678 0.85543299203799 -0.59501790258997 0.120940784150595 mirMAP;miRNATAP -0.424041122374258 5.1231691525337e-05 NA NA NA hsa-let-7a-3p GREM1 0.215598045625678 0.85543299203799 -0.195001590226282 0.897443638861798 mirMAP -0.893834427289059 2.17444389636331e-08 NA NA NA hsa-let-7a-3p GRIN2A 0.215598045625678 0.85543299203799 -0.268474819739478 0.788445562803975 mirMAP -0.682673872890101 8.80479134013245e-06 NA NA NA hsa-miR-132-3p GSK3B 0.244143673573889 0.871752726220643 0.0279273799391531 0.984168396316634 mirMAP;miRNATAP -0.110221716663843 0.000912142142693881 NA NA NA hsa-miR-146b-3p GSK3B 0.408862981477662 0.76252054047886 0.0279273799391531 0.984168396316634 miRNATAP -0.124674628963768 4.92920707796624e-08 NA NA NA hsa-miR-146b-5p GSK3B 0.402662509440885 0.837510937985092 0.0279273799391531 0.984168396316634 miRanda -0.144433253868449 1.55437010316677e-09 NA NA NA hsa-miR-155-5p GSK3B 0.407235807706004 0.828669616718496 0.0279273799391531 0.984168396316634 miRNAWalker2_validate;miRNATAP -0.101330604682835 1.443796438774e-06 NA NA NA hsa-miR-212-3p GSK3B 0.0224067199236493 0.973232008101457 0.0279273799391531 0.984168396316634 mirMAP;miRNATAP -0.114396409575091 1.59972400030542e-05 NA NA NA hsa-let-7a-3p GTF2A1 0.215598045625678 0.85543299203799 0.289461304122559 0.671821405861872 MirTarget;miRNATAP -0.180737031030294 0.000495425656136684 NA NA NA hsa-let-7a-3p GTF2I 0.215598045625678 0.85543299203799 0.108310388012569 0.943330693616186 MirTarget -0.106563156563109 0.0102296332451555 NA NA NA hsa-let-7a-3p GULP1 0.215598045625678 0.85543299203799 -0.267416694815477 0.705215014168461 MirTarget;mirMAP -0.612870551730645 4.98402295410739e-09 NA NA NA hsa-let-7a-3p HCFC2 0.215598045625678 0.85543299203799 0.0436647102974943 0.949454748944692 miRNATAP -0.234232618366014 1.2174608132371e-06 NA NA NA hsa-let-7a-3p HDAC9 0.215598045625678 0.85543299203799 -1.04923076955459 0.0425177186990654 miRNATAP -0.417395572708732 0.000362735696464937 NA NA NA hsa-let-7a-3p HDX 0.215598045625678 0.85543299203799 -0.213884151958921 0.626900589427636 mirMAP -0.414508531356488 0.000684683114507113 NA NA NA hsa-let-7a-3p HECTD2 0.215598045625678 0.85543299203799 -0.273633449076488 0.520886013901422 miRNATAP -0.427462015855406 2.90749733539747e-09 NA NA NA hsa-let-7a-3p HGF 0.215598045625678 0.85543299203799 0.215102594830841 0.643434051530302 mirMAP -0.88420347185405 1.1709285303706e-11 NA NA NA hsa-let-7a-3p HHIP 0.215598045625678 0.85543299203799 -0.559721650231381 0.331886542536477 mirMAP -0.858795930138885 1.41232355504352e-07 NA NA NA hsa-let-7a-3p HIC1 0.215598045625678 0.85543299203799 -0.262163443752532 0.680508435035587 MirTarget -0.333832535637522 1.50370719651293e-05 NA NA NA hsa-let-7a-3p HIP1 0.215598045625678 0.85543299203799 -0.0890854722266576 0.932256558696415 MirTarget;miRNATAP -0.195067738691898 0.00126000013783693 NA NA NA hsa-let-7a-3p HIPK3 0.215598045625678 0.85543299203799 0.12295318380863 0.912209410816989 mirMAP -0.264297700399773 2.21278413162999e-07 NA NA NA hsa-let-7a-3p HIVEP2 0.215598045625678 0.85543299203799 0.0770131756252717 0.946479540904921 miRNATAP -0.120046187052893 0.00301849747253993 NA NA NA hsa-let-7a-3p HLF 0.215598045625678 0.85543299203799 -0.055153204233935 0.89079919783947 mirMAP -0.28369345732238 0.0055693694008634 NA NA NA hsa-let-7a-3p HOOK3 0.215598045625678 0.85543299203799 -0.083261459848754 0.941750042972531 MirTarget -0.142907141848588 0.00367248470160385 NA NA NA hsa-let-7a-3p HOXC8 0.215598045625678 0.85543299203799 -0.224451674532672 0.798910258762339 miRNATAP -0.413834900109151 0.0303125756855472 NA NA NA hsa-let-7a-3p IDS 0.215598045625678 0.85543299203799 -0.256229760511659 0.865045922849969 mirMAP -0.257564382804785 1.4044033135798e-08 NA NA NA hsa-let-7a-3p IFIT1 0.215598045625678 0.85543299203799 -0.431108007716276 0.583376201069494 MirTarget -0.39197945578924 0.00117327802200347 NA NA NA hsa-let-7a-3p IGF1 0.215598045625678 0.85543299203799 -0.00947737435165086 0.987467926907962 mirMAP -1.080447980324 1.8079365656541e-11 NA NA NA hsa-let-7a-3p IGFBP3 0.215598045625678 0.85543299203799 -0.568859949215389 0.726718119187305 miRNATAP -0.427943062808335 1.71361067788621e-07 NA NA NA hsa-let-7a-3p IL6ST 0.215598045625678 0.85543299203799 0.112823587378398 0.902159423718375 mirMAP -0.462380603035303 1.58090637221431e-08 NA NA NA hsa-let-7a-3p IPMK 0.215598045625678 0.85543299203799 0.194336598501413 0.679868482570555 mirMAP -0.141777827524199 0.0212061280796338 NA NA NA hsa-let-7a-3p ITGAV 0.215598045625678 0.85543299203799 -0.0148858503591169 0.992317033809225 MirTarget -0.277150422479031 4.02095600400644e-08 NA NA NA hsa-let-7a-3p JAG1 0.215598045625678 0.85543299203799 0.0236629331049887 0.987743160638715 MirTarget;miRNATAP -0.123995296282957 0.0347215471551958 NA NA NA hsa-miR-155-5p JUN 0.407235807706004 0.828669616718496 0.201282056727359 0.914586369654736 miRNAWalker2_validate;miRTarBase -0.142048588673909 0.0138631645666983 23693020 In the present study we demonstrated for the first time that activation of RAGE by S100P regulates oncogenic microRNA-155 miR-155 expression through Activator Protein-1 AP-1 stimulation in colon cancer cells colon cancer hsa-let-7a-3p KCNJ15 0.215598045625678 0.85543299203799 0.03184822888329 0.949418419515852 MirTarget -0.756608284385165 5.18752796366538e-08 NA NA NA hsa-let-7a-3p KCTD12 0.215598045625678 0.85543299203799 0.392219877138569 0.766001676123232 MirTarget -0.44705454065704 2.44414686577257e-05 NA NA NA hsa-let-7a-3p KCTD15 0.215598045625678 0.85543299203799 0.185256763709838 0.833214470759545 miRNATAP -0.277863622377142 0.0013208347140948 NA NA NA hsa-let-7a-3p KIAA0408 0.215598045625678 0.85543299203799 -0.58178691699823 0.646984388278162 MirTarget -0.648887511918315 0.00118313058758307 NA NA NA hsa-let-7a-3p KIAA2022 0.215598045625678 0.85543299203799 -0.681486862146998 0.439640719575263 MirTarget;mirMAP -1.0134723822977 1.16098383913344e-11 NA NA NA hsa-let-7a-3p KIF5C 0.215598045625678 0.85543299203799 -0.278248607181943 0.413752536870909 miRNATAP -0.244696177529361 0.0127359727333551 NA NA NA hsa-let-7a-3p KIT 0.215598045625678 0.85543299203799 -0.457668701771759 0.496616548931543 mirMAP -0.3809217229143 0.00182630278028915 NA NA NA hsa-let-7a-3p KLF12 0.215598045625678 0.85543299203799 -0.712226486695754 0.328284448946846 MirTarget -0.243767405183734 0.0137811475173317 NA NA NA hsa-let-7a-3p KLF7 0.215598045625678 0.85543299203799 -0.459391940558039 0.405622541411287 miRNATAP -0.260480268831857 0.00399934229946505 NA NA NA hsa-let-7a-3p KLF8 0.215598045625678 0.85543299203799 -0.192971868363271 0.581484356279839 mirMAP -0.482446483385725 6.98231469266266e-08 NA NA NA hsa-let-7a-3p KLHL20 0.215598045625678 0.85543299203799 -0.0497718263184974 0.956518548702683 MirTarget -0.119351441620932 0.000228566189795446 NA NA NA hsa-let-7a-3p KLHL4 0.215598045625678 0.85543299203799 -0.831111085448837 0.152700107528867 mirMAP -0.799272292300742 3.08517454874839e-10 NA NA NA hsa-let-7a-3p KPNA5 0.215598045625678 0.85543299203799 0.261142033390528 0.343673300584919 mirMAP -0.154341847554917 0.0240009751459629 NA NA NA hsa-let-7a-3p LAMP2 0.215598045625678 0.85543299203799 -0.119359166394565 0.944412599679969 mirMAP;miRNATAP -0.116853592876946 0.00637030084647504 NA NA NA hsa-let-7a-3p LATS1 0.215598045625678 0.85543299203799 0.20474068087616 0.817643525404982 MirTarget;mirMAP -0.117427799621448 0.0108454612093953 NA NA NA hsa-let-7a-3p LCOR 0.215598045625678 0.85543299203799 0.384340349642144 0.540630047402759 mirMAP;miRNATAP -0.182032382696032 0.00515621686626681 NA NA NA hsa-let-7a-3p LEF1 0.215598045625678 0.85543299203799 -0.372363769452591 0.672169186275723 miRNATAP -0.376892958550269 4.01542672003822e-05 NA NA NA hsa-miR-26b-5p LEF1 0.0245931278499594 0.990377966314923 -0.372363769452591 0.672169186275723 miRNATAP -0.418971196571213 0.000163882839340634 24785257 miR26b is downregulated in several cancers and tumors and miR26b directly targets the lymphoid enhancer factor 1 Lef13'UTR and inhibits endogenous Lef1 expression; We report that miR26b expression is associated with human colon cancer through the regulation of LEF1 expression in colon cancer cells; Analyses of multiple colon cancer cell lines revealed an inverse correlation between miR26b and LEF1 expression; Normal human colon cells express low levels of LEF1 and high levels of miR26b; however human colon cancer cells have decreased miR26b expression and increased LEF1 expression; We demonstrate that miR26b expression is a potent inhibitor of colon cancer cell proliferation and significantly decreases LEF1 expression; Analyses of human colon cancer databases also demonstrated a link between miR26b and LEF1 expression colon cancer hsa-miR-335-3p LEF1 0.244830745789441 0.884500191166311 -0.372363769452591 0.672169186275723 mirMAP -0.216958845734393 0.00449894889910492 NA NA NA hsa-miR-33a-3p LEF1 0.794543849238582 0.0105203072007922 -0.372363769452591 0.672169186275723 miRNATAP -0.236080809003934 0.000829038399450042 NA NA NA hsa-miR-455-5p LEF1 0.139599153671263 0.865744220236311 -0.372363769452591 0.672169186275723 miRanda -0.18273794099189 0.0320000202127226 NA NA NA hsa-miR-502-5p LEF1 0.708507838520586 0.0261309781860105 -0.372363769452591 0.672169186275723 miRNATAP -0.165753497322919 0.0159228033131464 NA NA NA hsa-miR-590-3p LEF1 0.27924475537686 0.591266699336619 -0.372363769452591 0.672169186275723 PITA;miRanda;mirMAP -0.406214238447069 1.97986726304738e-09 NA NA NA hsa-miR-7-1-3p LEF1 0.462485777435991 0.665899751398166 -0.372363769452591 0.672169186275723 mirMAP -0.37128315594906 4.16815851332667e-06 NA NA NA hsa-let-7a-3p LEPR 0.215598045625678 0.85543299203799 -0.642200122826726 0.284902873327858 mirMAP -0.222152295467266 0.00453719470781161 NA NA NA hsa-let-7a-3p LIFR 0.215598045625678 0.85543299203799 -0.297225879773933 0.536497058727361 mirMAP -0.672277431183378 1.66141312929081e-08 NA NA NA hsa-let-7a-3p LIMS1 0.215598045625678 0.85543299203799 0.280204232810378 0.769440572906396 mirMAP -0.281477201884279 1.8895448002623e-10 NA NA NA hsa-let-7a-3p LIMS3 0.215598045625678 0.85543299203799 -0.333941369524497 0.705362166541236 MirTarget -0.362058744286417 0.00250804034193844 NA NA NA hsa-let-7a-3p LIN7A 0.215598045625678 0.85543299203799 -0.0801991896147243 0.901651117112341 mirMAP -0.470725411984581 0.0060751985466822 NA NA NA hsa-let-7a-3p LMO3 0.215598045625678 0.85543299203799 -0.429959260162575 0.526763996816997 MirTarget -1.31720632812077 6.58525679826344e-12 NA NA NA hsa-let-7a-3p LRCH3 0.215598045625678 0.85543299203799 0.214333134852446 0.796305652849224 mirMAP -0.140740536744936 6.69674504856347e-05 NA NA NA hsa-miR-29c-3p LRP6 -0.1624517002027 0.94272045751251 -0.00929586358621037 0.994164444256215 miRNATAP -0.117273903260117 0.000337062728866153 NA NA NA hsa-let-7a-3p LRRC32 0.215598045625678 0.85543299203799 -0.431980015893379 0.725111829549726 MirTarget;miRNATAP -0.427118098222409 2.37050602903931e-08 NA NA NA hsa-let-7a-3p LRRC4 0.215598045625678 0.85543299203799 -0.0521576208699549 0.896659813458363 miRNATAP -0.400037615695035 0.000354211844721839 NA NA NA hsa-let-7a-3p LRRC8C 0.215598045625678 0.85543299203799 0.10284704054603 0.886647987449934 mirMAP -0.28962358850819 9.30069894549611e-06 NA NA NA hsa-let-7a-3p LRRK2 0.215598045625678 0.85543299203799 0.0633534750621314 0.899194903115367 mirMAP -0.854943086038784 2.27507965632339e-10 NA NA NA hsa-let-7a-3p LSP1 0.215598045625678 0.85543299203799 0.157556198446683 0.890338554687983 MirTarget -0.360972523147935 4.80786809193223e-05 NA NA NA hsa-let-7a-3p MAFB 0.215598045625678 0.85543299203799 -0.126692630929701 0.889300835708415 miRNATAP -0.582328354287651 1.26443244826702e-08 NA NA NA hsa-let-7a-3p MALT1 0.215598045625678 0.85543299203799 0.230924182298793 0.827464134893132 MirTarget -0.100967794066316 0.0259426032137535 NA NA NA hsa-let-7a-3p MAN1A1 0.215598045625678 0.85543299203799 0.0618801202215487 0.960438452615897 MirTarget -0.165394175457017 0.0270660277910747 NA NA NA hsa-let-7a-3p MAP1B 0.215598045625678 0.85543299203799 -0.489371002546808 0.569761285898293 mirMAP -0.551920209635696 1.84168643146647e-09 NA NA NA hsa-let-7a-3p MAP2 0.215598045625678 0.85543299203799 -0.756343154308637 0.0495352956728121 MirTarget;miRNATAP -0.618358819954705 1.44808333013156e-08 NA NA NA hsa-let-7a-3p MAP9 0.215598045625678 0.85543299203799 -0.686788640415317 0.147078196031767 mirMAP -0.720358811340553 2.6339264668964e-09 NA NA NA hsa-miR-130b-3p MAPK10 0.221667315324818 0.824660172394714 -0.277853609916948 0.499757905156418 miRNATAP -0.832310234327384 2.2381048276646e-17 NA NA NA hsa-miR-193a-3p MAPK10 0.247265785363731 0.654363581941635 -0.277853609916948 0.499757905156418 miRanda;miRNATAP -0.252213365553003 0.00870398994376484 NA NA NA hsa-miR-19a-3p MAPK10 0.206793507801887 0.844637784802316 -0.277853609916948 0.499757905156418 miRNATAP -0.684018875973696 4.827389622141e-18 NA NA NA hsa-miR-19b-3p MAPK10 0.0268530183621465 0.986656783046573 -0.277853609916948 0.499757905156418 miRNATAP -0.696419816886425 6.76561876995665e-13 NA NA NA hsa-miR-221-3p MAPK10 -0.0906940388127522 0.959121118272534 -0.277853609916948 0.499757905156418 miRNATAP -0.85742573028989 1.01791917727309e-12 NA NA NA hsa-miR-222-3p MAPK10 0.0265849318772684 0.984005474689109 -0.277853609916948 0.499757905156418 miRNATAP -0.880593901403205 6.71481319542536e-17 NA NA NA hsa-miR-29a-3p MAPK10 -0.0112747441028436 0.996977020481271 -0.277853609916948 0.499757905156418 miRNATAP -0.691098479445333 1.45128452412974e-07 NA NA NA hsa-miR-29b-3p MAPK10 0.104016192263954 0.958988036765397 -0.277853609916948 0.499757905156418 miRNATAP -0.761303371269869 1.76988052622429e-15 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-301a-3p MAPK10 0.10531251190177 0.831686745977346 -0.277853609916948 0.499757905156418 miRNATAP -0.612353493044439 4.61795457460633e-13 NA NA NA hsa-miR-30d-3p MAPK10 0.123474741320297 0.814905367625793 -0.277853609916948 0.499757905156418 mirMAP -0.796380211200875 1.85348051868985e-13 NA NA NA hsa-miR-30e-3p MAPK10 0.220498559176349 0.938660731870214 -0.277853609916948 0.499757905156418 mirMAP -0.516722605634317 0.00602241545561428 NA NA NA hsa-miR-330-3p MAPK10 -0.00298687748748439 0.994504006750491 -0.277853609916948 0.499757905156418 PITA;miRNATAP -0.375477945370297 0.000760398661857965 NA NA NA hsa-miR-429 MAPK10 0.456485631615963 0.806240953400535 -0.277853609916948 0.499757905156418 miRNATAP -0.63546405917023 3.52018243839143e-17 NA NA NA hsa-miR-450b-5p MAPK10 0.0136687538973108 0.983149761399849 -0.277853609916948 0.499757905156418 mirMAP -0.334790980428701 0.00164827821846065 NA NA NA hsa-miR-454-3p MAPK10 0.101514866328012 0.84354515825619 -0.277853609916948 0.499757905156418 miRNATAP -0.717456429396768 1.33940482149645e-09 NA NA NA hsa-miR-455-5p MAPK10 0.139599153671263 0.865744220236311 -0.277853609916948 0.499757905156418 miRanda -0.270878318986493 0.00909782838990037 NA NA NA hsa-miR-548o-3p MAPK10 0.191447572716993 0.517725546183501 -0.277853609916948 0.499757905156418 mirMAP -0.462430047984935 4.46197714322552e-07 NA NA NA hsa-miR-582-5p MAPK10 0.399450205475138 0.581227478860085 -0.277853609916948 0.499757905156418 PITA -0.605577911431605 1.99297551024098e-08 NA NA NA hsa-miR-590-3p MAPK10 0.27924475537686 0.591266699336619 -0.277853609916948 0.499757905156418 miRanda;mirMAP -0.669311815061267 4.2846409042703e-17 NA NA NA hsa-miR-590-5p MAPK10 0.547819833829572 0.472735645776647 -0.277853609916948 0.499757905156418 PITA;miRanda;miRNATAP -0.775102686172998 6.76449100692106e-21 NA NA NA hsa-miR-935 MAPK10 -0.0536667023984383 0.939418255464024 -0.277853609916948 0.499757905156418 miRNATAP -0.225220660326491 1.42825991928949e-07 NA NA NA hsa-miR-940 MAPK10 0.225788347550697 0.680055767105815 -0.277853609916948 0.499757905156418 PITA;miRNATAP -0.415226368453551 5.09031496952449e-09 NA NA NA hsa-miR-130a-3p MAPK8 -0.0910074087716906 0.929098200371948 0.319170851710442 0.713899940923572 mirMAP -0.147493968259864 1.00993606990742e-06 NA NA NA hsa-miR-193b-3p MAPK8 -0.0672068426635715 0.951480422273678 0.319170851710442 0.713899940923572 miRNAWalker2_validate -0.106177901094541 0.00010813031062645 NA NA NA hsa-miR-214-3p MAPK8 -0.198015895663265 0.797041683257943 0.319170851710442 0.713899940923572 miRNAWalker2_validate -0.106280310352835 1.00012795110538e-06 19859982 HeLa cells that stably overexpress miR-214 downregulate the expression of MEK3 and JNK1 at both mRNA and protein levels; Further investigation revealed that miR-214 regulates the expression of MEK3 and JNK1 by targeting the 3'UTRs of these genes; Collectively these results suggest that miR-214 negatively regulates HeLa cell proliferation by targeting the noncoding regions of MEK3 and JNK1 mRNAs cervical and endocervical cancer hsa-miR-22-5p MAPK8 0.0785922550675187 0.93169760098231 0.319170851710442 0.713899940923572 mirMAP -0.129099178124462 4.99897569863785e-06 NA NA NA hsa-miR-30a-5p MAPK8 -0.219472325612347 0.933954023293815 0.319170851710442 0.713899940923572 mirMAP -0.109201955684847 0.01625133125464 NA NA NA hsa-miR-30b-5p MAPK8 0.0121430518253556 0.994622896704514 0.319170851710442 0.713899940923572 mirMAP -0.118491315163398 4.11391777534363e-05 NA NA NA hsa-miR-30c-5p MAPK8 0.298383882401475 0.865809030482001 0.319170851710442 0.713899940923572 mirMAP -0.136394758639834 0.00107809048076701 NA NA NA hsa-miR-376a-5p MAPK8 -0.097868085684955 0.773217338913053 0.319170851710442 0.713899940923572 mirMAP -0.102493277664627 6.72583489111155e-05 NA NA NA hsa-miR-495-3p MAPK8 -0.00168200867117552 0.997533662527026 0.319170851710442 0.713899940923572 mirMAP -0.146650526517664 7.87292470161155e-05 NA NA NA hsa-let-7i-5p MAPK9 0.200792135853451 0.922018647874073 0.0687722126219112 0.958326759664496 miRNATAP -0.139568596213236 0.00470113649742568 NA NA NA hsa-miR-199a-3p MAPK9 -0.0782166873040406 0.973766909565327 0.0687722126219112 0.958326759664496 miRNAWalker2_validate -0.100016761572209 0.00211211499601589 NA NA NA hsa-let-7a-3p MARCH1 0.215598045625678 0.85543299203799 0.267494029887533 0.416129904305181 miRNATAP -0.367746412330056 5.30556900735131e-06 NA NA NA hsa-let-7a-3p MAST4 0.215598045625678 0.85543299203799 0.143747046906517 0.854058250504115 miRNATAP -0.231053452897492 0.00143172473764831 NA NA NA hsa-let-7a-3p MBNL3 0.215598045625678 0.85543299203799 0.132374024309428 0.78684284441636 mirMAP;miRNATAP -0.206480344455515 0.00709988290303339 NA NA NA hsa-let-7a-3p MDFIC 0.215598045625678 0.85543299203799 -0.0462135025255108 0.95667601906837 MirTarget -0.326537816031061 0.000390628085805528 NA NA NA hsa-let-7a-3p MEF2A 0.215598045625678 0.85543299203799 -0.036653789174653 0.97502480056443 mirMAP -0.103322051099513 0.00171123607812761 NA NA NA hsa-let-7a-3p MEF2C 0.215598045625678 0.85543299203799 -0.174491220363078 0.828081225511472 MirTarget;miRNATAP -0.444495121511938 2.38223100299587e-08 NA NA NA hsa-let-7a-3p MEX3B 0.215598045625678 0.85543299203799 -0.0501548149246174 0.893157445722901 miRNATAP -0.426479850375075 2.15872435242819e-08 NA NA NA hsa-let-7a-3p MFAP3L 0.215598045625678 0.85543299203799 0.236684207693141 0.712552158927776 mirMAP -0.237450951910968 0.0332582685373011 NA NA NA hsa-let-7a-3p MGAT5 0.215598045625678 0.85543299203799 0.282672014096316 0.789040804874783 mirMAP -0.172469479098789 0.0203017005254976 NA NA NA hsa-let-7a-3p MITF 0.215598045625678 0.85543299203799 -0.31090852637847 0.634528825875931 MirTarget;miRNATAP -0.627542324270645 1.05620850068141e-09 NA NA NA hsa-miR-126-3p MMP7 0.106293136341572 0.963670566555252 0.276459182384983 0.831441864604978 miRNAWalker2_validate -0.722864708331936 0.000783652940961068 NA NA NA hsa-miR-126-5p MMP7 -0.0815213541035842 0.956637332055184 0.276459182384983 0.831441864604978 miRNAWalker2_validate -0.544179509358285 0.0140672062582973 NA NA NA hsa-miR-542-3p MMP7 -0.188168046511374 0.909252939431573 0.276459182384983 0.831441864604978 miRanda -0.448774654452346 0.0324699595226584 NA NA NA hsa-miR-590-3p MMP7 0.27924475537686 0.591266699336619 0.276459182384983 0.831441864604978 miRanda -0.388494612023758 0.00681400444644842 NA NA NA hsa-miR-590-5p MMP7 0.547819833829572 0.472735645776647 0.276459182384983 0.831441864604978 miRanda -0.525145355146763 0.000505782911901656 NA NA NA hsa-let-7a-3p MSRB3 0.215598045625678 0.85543299203799 -0.468716605173428 0.626813284566038 miRNATAP -0.846954699893699 4.06459966851557e-15 NA NA NA hsa-let-7a-3p MTMR9 0.215598045625678 0.85543299203799 0.30427324292953 0.695341024861325 mirMAP -0.136638639697206 0.00196435926484329 NA NA NA hsa-let-7c-5p MYC 0.0629831812743404 0.974895834249241 0.445372871610816 0.811492365164222 miRNAWalker2_validate;miRTarBase -0.120369217886316 0.0156769064824719 22128178 MicroRNA let 7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells prostate cancer hsa-miR-145-5p MYC -0.0379358609701423 0.987582252034038 0.445372871610816 0.811492365164222 miRNAWalker2_validate;miRTarBase -0.127824497158615 0.0230655414672401 23499891;21690566;27482839;23919393;21836381;24356567;21092188;21723890 The ectopic expression of miR-145 inhibited the growth of DLD-1 cells by disturbing β-catenin translocation into the nucleus thereby leading to the down-regulation of LEF/TCF transcriptional target genes c-Myc and CyclinD1;miR-145 delivery reduced tumor proliferation and increased apoptosis with concomitant repression of c-Myc and ERK5 as novel regulatory target of miR-145;Consequently the increased miR-145 induced G1 cell cycle arrest reduced tumor proliferation and increased apoptosis inhibited HCT-116 cell migration and suppressed c-MYC expressions a regulatory target of miR-145;MicroRNA 145 function as a cell growth repressor by directly targeting c Myc in human ovarian cancer; We show that miR-145 directly target the c-Myc 3'-UTR; Moreover ectopic expression of c-Myc reduces the inhibition of cell proliferation caused by miR-145 transfection; Cell cycle assay showed that up-regulation of miR-145 reduces S phase population and restoration of c-Myc can rescue this reduction; These findings indicate that miR-145 inhibits cell proliferation and promotes cell apoptosis by targeting c-Myc 3'-UTR;The ectopic expression of miR-145 showed a significant growth inhibition in both canine and human melanoma cells tested and the effect was achieved partly by suppressing c-MYC in canine melanoma LMeC and in human melanoma A2058 and Mewo cells;miR 145 inhibits proliferation and invasion of esophageal squamous cell carcinoma in part by targeting c Myc; The impact of overexpression of miR-145 on putative target c-Myc was subsequently confirmed via Western blot; Overexpression of miR-145 significantly decreased p < 0.05 the protein level of c-Myc which has previously been identified as a direct target of miR-145; Our results demonstrate that overexpression of miR-145 inhibits tumor growth in part by targeting c-Myc;In colon cancer cells c-Myc is a confirmed direct target for miR-145; The aim of this work was to investigate the effect of miR-145 and c-Myc on proliferation of NSCLC cells using the NSCLC cell lines A549 and H23 as models; We further showed that c-Myc was a direct target for miR-145; Taken together our study results demonstrate that miR-145 inhibits proliferation of NSCLC cells through c-Myc;We found a reverse-correlation between the expression of miR-145 and its target genes such as fascin-1 c-myc SMAD2/3 and IGF-1R in breast cancer cell lines and breast cancer patient tissues ;;cell migration;;;;; colon cancer;colon cancer;colon cancer;ovarian cancer;melanoma;esophageal cancer;lung squamous cell cancer;breast cancer hsa-miR-320a MYC 0.41654643376763 0.840202138616421 0.445372871610816 0.811492365164222 miRNAWalker2_validate -0.191731059391187 0.0116266870694963 25736597 Furthermore progesterone P4 promoted the expression of miR-320a by repressing c-Myc expression while estrogen E2 exerted the opposite effect breast cancer hsa-miR-320b MYC 0.23561798088153 0.859222532827992 0.445372871610816 0.811492365164222 miRNAWalker2_validate -0.243607030835589 0.000321638494084035 26487644 miR 320b suppresses cell proliferation by targeting c Myc in human colorectal cancer cells; Overexpression of miR-320b in CRC cells was statistically correlated with a decrease of cell growth in vitro and in vivo while c-MYC was identified as a target gene of miR-320b in CRC; Furthermore it was found that up-regulation of c-Myc can attenuate the effects induced by miR-320b; Our identification of c-MYC as a target gene of miR-320b provides new insights into the pathophysiology of CRC proliferation and identifies miR-320b as a novel therapeutic target for the treatment of CRC colorectal cancer hsa-let-7a-3p MYCBP2 0.215598045625678 0.85543299203799 -0.262332792101246 0.848851381475127 MirTarget;miRNATAP -0.10905335040602 0.024833920584512 NA NA NA hsa-let-7a-3p MYLK 0.215598045625678 0.85543299203799 -0.514165053784478 0.725290453217071 mirMAP -0.830839649170453 7.14260540967775e-15 NA NA NA hsa-let-7a-3p MYO9A 0.215598045625678 0.85543299203799 0.241649416699063 0.743447408051602 mirMAP -0.224737685178797 4.60047039667553e-05 NA NA NA hsa-let-7a-3p N4BP2 0.215598045625678 0.85543299203799 0.355904578535003 0.543093014548922 mirMAP -0.258825289334365 4.38665170506086e-05 NA NA NA hsa-let-7a-3p NALCN 0.215598045625678 0.85543299203799 -0.994074936208112 0.172084782822279 MirTarget -1.02575666908749 2.9906002423697e-09 NA NA NA hsa-let-7a-3p NAV1 0.215598045625678 0.85543299203799 -0.372445346440196 0.744795005097417 miRNATAP -0.268610957463315 0.000603529536705886 NA NA NA hsa-let-7a-3p NBEA 0.215598045625678 0.85543299203799 -0.319609331585412 0.529294820904304 MirTarget;miRNATAP -0.613257467969188 3.05077219560266e-05 NA NA NA hsa-let-7a-3p NCAM1 0.215598045625678 0.85543299203799 0.120146355426511 0.822713111149455 miRNATAP -0.609340379030434 5.46665932846602e-06 NA NA NA hsa-let-7a-3p NECAB1 0.215598045625678 0.85543299203799 -0.53884318847982 0.186847734504168 MirTarget;miRNATAP -0.705695427095752 5.64826223962848e-12 NA NA NA hsa-let-7a-3p NEDD4 0.215598045625678 0.85543299203799 -0.0637381756285 0.949462295202686 mirMAP -0.178051103060118 0.00479882828862927 NA NA NA hsa-let-7a-3p NEK7 0.215598045625678 0.85543299203799 -0.228773407116736 0.859512032792458 mirMAP -0.127336180301948 0.00186058242584064 NA NA NA hsa-let-7a-3p NFASC 0.215598045625678 0.85543299203799 -0.296817291389491 0.695079496905732 miRNATAP -0.381670905529763 0.000606558848701117 NA NA NA hsa-miR-132-3p NFAT5 0.244143673573889 0.871752726220643 -0.236883935946429 0.868755608472164 miRNATAP -0.303143600097309 2.16558109693786e-06 NA NA NA hsa-miR-140-3p NFAT5 0.369894078407762 0.864762211761538 -0.236883935946429 0.868755608472164 miRNATAP -0.225328079189035 0.00235415520685202 NA NA NA hsa-miR-146b-5p NFAT5 0.402662509440885 0.837510937985092 -0.236883935946429 0.868755608472164 miRanda -0.200410606753385 2.59202637244169e-05 NA NA NA hsa-miR-155-5p NFAT5 0.407235807706004 0.828669616718496 -0.236883935946429 0.868755608472164 mirMAP;miRNATAP -0.15151678093381 0.000258720624622913 NA NA NA hsa-miR-21-3p NFAT5 0.395016549347051 0.878199827735651 -0.236883935946429 0.868755608472164 MirTarget -0.181552783273077 0.000288869690237049 NA NA NA hsa-miR-21-5p NFAT5 0.14892088710744 0.970240620972125 -0.236883935946429 0.868755608472164 miRNAWalker2_validate;mirMAP -0.286300896256841 5.47270739628322e-05 NA NA NA hsa-miR-212-3p NFAT5 0.0224067199236493 0.973232008101457 -0.236883935946429 0.868755608472164 miRNATAP -0.103541833598137 0.0489507617641425 NA NA NA hsa-miR-381-3p NFAT5 -0.0562600264188893 0.966895219811624 -0.236883935946429 0.868755608472164 mirMAP -0.124551697632845 0.0409282900381601 NA NA NA hsa-miR-409-3p NFAT5 0.0435834098303647 0.96355659631538 -0.236883935946429 0.868755608472164 PITA;mirMAP -0.105589426744638 0.0450115168224482 NA NA NA hsa-miR-511-5p NFAT5 0.308591187445275 0.607200373476563 -0.236883935946429 0.868755608472164 MirTarget -0.109843348298306 0.00293390271527846 NA NA NA hsa-miR-582-3p NFAT5 0.2334649592375 0.897678119160318 -0.236883935946429 0.868755608472164 MirTarget -0.170498476348806 0.000104354261623335 NA NA NA hsa-miR-582-5p NFAT5 0.399450205475138 0.581227478860085 -0.236883935946429 0.868755608472164 MirTarget;PITA;miRNATAP -0.146117556547861 0.00140030250954287 NA NA NA hsa-miR-889-3p NFAT5 -0.16596974586203 0.848786745366372 -0.236883935946429 0.868755608472164 MirTarget -0.165016738249516 0.00648208856160109 NA NA NA hsa-miR-92b-3p NFAT5 0.569866984318693 0.689321861489778 -0.236883935946429 0.868755608472164 miRNATAP -0.184775604374122 3.95589693734067e-06 NA NA NA hsa-miR-421 NFATC1 0.182032017078617 0.734704500318599 0.122281733605435 0.852345442732836 miRanda -0.575230730616861 5.87588180760931e-11 NA NA NA hsa-miR-542-3p NFATC1 -0.188168046511374 0.909252939431573 0.122281733605435 0.852345442732836 miRanda -0.295894419929371 0.010908361010745 NA NA NA hsa-miR-940 NFATC1 0.225788347550697 0.680055767105815 0.122281733605435 0.852345442732836 PITA -0.297982460990984 9.74621969187875e-06 NA NA NA hsa-miR-130b-5p NFATC2 0.6472141103776 0.379096015222509 -0.208138850041581 0.707327065065389 MirTarget -0.371671936709306 0.000945478291859101 NA NA NA hsa-miR-146a-5p NFATC2 0.581292803346902 0.736851349367572 -0.208138850041581 0.707327065065389 mirMAP -0.250087935561372 0.0110078235288249 NA NA NA hsa-miR-16-2-3p NFATC2 0.36717860153421 0.546850726070016 -0.208138850041581 0.707327065065389 mirMAP -0.321323681153577 0.00260222712022902 NA NA NA hsa-miR-182-5p NFATC2 0.10423849794055 0.973380614062244 -0.208138850041581 0.707327065065389 mirMAP -0.265681273078806 0.00971009673872175 NA NA NA hsa-miR-185-5p NFATC2 0.294432218239008 0.820591478398594 -0.208138850041581 0.707327065065389 MirTarget -0.395271766735011 0.0160654734166251 NA NA NA hsa-miR-200b-5p NFATC2 0.502275384207407 0.722255155236926 -0.208138850041581 0.707327065065389 mirMAP -0.305745975197229 0.00378458633137365 NA NA NA hsa-miR-222-3p NFATC2 0.0265849318772684 0.984005474689109 -0.208138850041581 0.707327065065389 MirTarget -0.320366258251818 0.012848061977003 NA NA NA hsa-miR-26b-3p NFATC2 0.363222538866816 0.681115126930067 -0.208138850041581 0.707327065065389 MirTarget -0.317033936764729 0.00865242756037893 NA NA NA hsa-miR-29a-5p NFATC2 0.31835175571979 0.600442757817281 -0.208138850041581 0.707327065065389 mirMAP;miRNATAP -0.214322201239072 0.044721721171523 NA NA NA hsa-miR-30c-5p NFATC2 0.298383882401475 0.865809030482001 -0.208138850041581 0.707327065065389 MirTarget;mirMAP -0.365096516052362 0.0265241269847483 NA NA NA hsa-miR-31-3p NFATC2 -0.199700996192122 0.762032341762692 -0.208138850041581 0.707327065065389 MirTarget -0.235283031776912 5.29901232164249e-06 NA NA NA hsa-miR-340-5p NFATC2 0.00276909425328897 0.997573611610549 -0.208138850041581 0.707327065065389 miRNATAP -0.352511827102355 0.00983626337497569 NA NA NA hsa-miR-484 NFATC2 0.17997720269125 0.886333755572375 -0.208138850041581 0.707327065065389 MirTarget -0.415370166828549 0.00430698140074031 NA NA NA hsa-miR-590-3p NFATC2 0.27924475537686 0.591266699336619 -0.208138850041581 0.707327065065389 mirMAP -0.338313979685588 0.000466556910823497 NA NA NA hsa-miR-7-1-3p NFATC2 0.462485777435991 0.665899751398166 -0.208138850041581 0.707327065065389 mirMAP -0.334924596713898 0.00323544853973565 NA NA NA hsa-miR-7-5p NFATC2 -0.209645143210378 0.773705612298442 -0.208138850041581 0.707327065065389 MirTarget;miRNATAP -0.222229993016084 0.00222704126347517 NA NA NA hsa-miR-1254 NFATC4 0.488929355953681 0.19551794273322 -0.226055021146127 0.800900855175489 MirTarget -0.168494924567814 0.000786858710678943 NA NA NA hsa-miR-130b-5p NFATC4 0.6472141103776 0.379096015222509 -0.226055021146127 0.800900855175489 mirMAP -0.233289219374898 0.000130008396840311 NA NA NA hsa-miR-15b-3p NFATC4 0.557749208157585 0.609181305423188 -0.226055021146127 0.800900855175489 mirMAP -0.270368257837691 2.79109512958001e-05 NA NA NA hsa-miR-185-3p NFATC4 -0.100697585937245 0.856913315942984 -0.226055021146127 0.800900855175489 MirTarget -0.161814286535747 0.0130745730330206 NA NA NA hsa-miR-29a-3p NFATC4 -0.0112747441028436 0.996977020481271 -0.226055021146127 0.800900855175489 miRNATAP -0.258362450735976 0.00188238181514646 NA NA NA hsa-miR-29b-3p NFATC4 0.104016192263954 0.958988036765397 -0.226055021146127 0.800900855175489 miRNATAP -0.225170145334363 0.000330589653812401 NA NA NA hsa-miR-320c NFATC4 0.577462251570141 0.113597318870228 -0.226055021146127 0.800900855175489 miRanda;mirMAP -0.136540488247642 0.00651845172795593 NA NA NA hsa-miR-361-3p NFATC4 0.285313945920493 0.847726816983045 -0.226055021146127 0.800900855175489 mirMAP -0.242143644855398 0.00961205807335463 NA NA NA hsa-miR-429 NFATC4 0.456485631615963 0.806240953400535 -0.226055021146127 0.800900855175489 miRNATAP -0.213342690177861 1.64741561365079e-05 NA NA NA hsa-miR-532-5p NFATC4 0.349665553500088 0.878948352437467 -0.226055021146127 0.800900855175489 mirMAP -0.261553245010297 2.98639232810069e-05 NA NA NA hsa-miR-625-5p NFATC4 0.690759472145278 0.210306534567564 -0.226055021146127 0.800900855175489 mirMAP -0.142491700464098 0.00216106794254422 NA NA NA hsa-miR-629-3p NFATC4 0.49540274581201 0.333967382214383 -0.226055021146127 0.800900855175489 mirMAP -0.197806130594455 8.82960626285602e-05 NA NA NA hsa-let-7a-3p NFIC 0.215598045625678 0.85543299203799 0.342630419031278 0.733345248835125 miRNATAP -0.145053153749338 0.0242803535160173 NA NA NA hsa-let-7a-5p NKD1 0.0620211756550386 0.985006886285189 -1.2522994182732 0.260002383804272 TargetScan -0.83997772532673 0.00326453234388339 NA NA NA hsa-miR-140-5p NKD1 0.229213026275907 0.847330111738614 -1.2522994182732 0.260002383804272 miRanda -0.551944001555799 0.0166707118254765 NA NA NA hsa-miR-21-5p NKD1 0.14892088710744 0.970240620972125 -1.2522994182732 0.260002383804272 mirMAP -0.600184868795665 0.0242146393070406 NA NA NA hsa-miR-330-5p NKD1 0.283418953659273 0.815687101334694 -1.2522994182732 0.260002383804272 miRanda;miRNATAP -0.730109518905697 0.000354165413242501 NA NA NA hsa-let-7a-3p NLGN1 0.215598045625678 0.85543299203799 -0.666176626379359 0.550454848157536 MirTarget;miRNATAP -0.998736412512457 3.34920193715702e-10 NA NA NA hsa-let-7b-5p NLK 0.228773940533777 0.938952933213742 -0.214434715599375 0.830839712962495 miRNATAP -0.130424977621627 0.00311102435446934 NA NA NA hsa-let-7e-5p NLK -0.211156073215582 0.922335699862928 -0.214434715599375 0.830839712962495 miRNATAP -0.143798339328613 0.00232162255220557 NA NA NA hsa-let-7i-5p NLK 0.200792135853451 0.922018647874073 -0.214434715599375 0.830839712962495 miRNATAP -0.185812755181517 0.00112341117007832 NA NA NA hsa-miR-132-3p NLK 0.244143673573889 0.871752726220643 -0.214434715599375 0.830839712962495 miRNATAP -0.198155050215153 3.50435694338891e-05 NA NA NA hsa-miR-146b-5p NLK 0.402662509440885 0.837510937985092 -0.214434715599375 0.830839712962495 miRanda -0.19099789381006 4.66750054492802e-08 NA NA NA hsa-miR-330-5p NLK 0.283418953659273 0.815687101334694 -0.214434715599375 0.830839712962495 MirTarget;PITA;miRanda;miRNATAP -0.119789137803744 0.00367235842016029 NA NA NA hsa-miR-342-3p NLK 0.371626144515113 0.77313668985267 -0.214434715599375 0.830839712962495 miRanda -0.124795455162205 7.92183179587525e-05 NA NA NA hsa-miR-511-5p NLK 0.308591187445275 0.607200373476563 -0.214434715599375 0.830839712962495 MirTarget -0.117056015401763 1.64388218292278e-05 NA NA NA hsa-miR-582-5p NLK 0.399450205475138 0.581227478860085 -0.214434715599375 0.830839712962495 miRNATAP -0.110737279228243 0.00112944181508768 NA NA NA hsa-let-7a-3p NOVA1 0.215598045625678 0.85543299203799 -0.97464498700172 0.153575483207489 miRNATAP -0.579514042843343 0.000212566285912952 NA NA NA hsa-let-7a-3p NPR3 0.215598045625678 0.85543299203799 -1.41670666533487 0.0695047833326634 MirTarget;miRNATAP -0.994012113925742 1.97867017777095e-08 NA NA NA hsa-let-7a-3p NPY1R 0.215598045625678 0.85543299203799 -1.21299701340514 0.0726502707784564 miRNATAP -0.483651095498001 0.0124516950113744 NA NA NA hsa-let-7a-3p NR3C1 0.215598045625678 0.85543299203799 -0.142140601342891 0.869725091526188 miRNATAP -0.505663275611618 7.45995353938247e-09 NA NA NA hsa-let-7a-3p NR4A3 0.215598045625678 0.85543299203799 -0.592846526216022 0.278473702469794 mirMAP -0.393965430664077 0.00133750983452919 NA NA NA hsa-let-7a-3p NRP1 0.215598045625678 0.85543299203799 -0.30402786571385 0.805493744682203 miRNATAP -0.469192021502807 4.76146272015568e-09 NA NA NA hsa-let-7a-3p NRP2 0.215598045625678 0.85543299203799 -0.636070176758863 0.573617100728668 miRNATAP -0.588403944571623 1.85499682046752e-10 NA NA NA hsa-let-7a-3p NRXN1 0.215598045625678 0.85543299203799 -0.974547340486697 0.339764670869568 MirTarget;miRNATAP -1.18923071949819 5.29554085336768e-10 NA NA NA hsa-let-7a-3p NTN4 0.215598045625678 0.85543299203799 0.187637028227141 0.837081302892729 MirTarget -0.165943659394208 0.0319335680143832 NA NA NA hsa-let-7a-3p NTRK3 0.215598045625678 0.85543299203799 -0.238305058900675 0.782779033789323 mirMAP -0.769711898091584 2.05674928401949e-07 NA NA NA hsa-let-7a-3p OLFML2B 0.215598045625678 0.85543299203799 -0.280112134128482 0.801604852111816 MirTarget;miRNATAP -0.588552633292754 9.10416222275103e-10 NA NA NA hsa-let-7a-3p OSBPL8 0.215598045625678 0.85543299203799 0.00704238691995052 0.995753982956424 mirMAP;miRNATAP -0.129490865707288 0.00134964936357086 NA NA NA hsa-let-7a-3p OXR1 0.215598045625678 0.85543299203799 -0.354274725524744 0.775286637822539 MirTarget;miRNATAP -0.133246372649334 0.00557193352620917 NA NA NA hsa-let-7a-3p PAFAH1B2 0.215598045625678 0.85543299203799 0.214296540900348 0.833389719963879 mirMAP -0.171554825132389 6.13823332693532e-05 NA NA NA hsa-let-7a-3p PCDH17 0.215598045625678 0.85543299203799 -0.143086776234921 0.823963657691363 miRNATAP -0.385803158347146 1.38014101436631e-06 NA NA NA hsa-let-7a-3p PCDH19 0.215598045625678 0.85543299203799 -0.431530633984229 0.480734112772708 miRNATAP -0.423595138615953 0.0199405807093135 NA NA NA hsa-let-7a-3p PCDH7 0.215598045625678 0.85543299203799 -0.798735200294771 0.296931633157699 mirMAP -0.726548432439984 1.39349595292317e-10 NA NA NA hsa-let-7a-3p PCSK2 0.215598045625678 0.85543299203799 -0.86375416914939 0.451515542910981 miRNATAP -0.676842079277183 3.30938759975244e-05 NA NA NA hsa-let-7a-3p PDE10A 0.215598045625678 0.85543299203799 -0.0606046465488559 0.906228042342898 mirMAP -0.315874872276348 0.00821215713619813 NA NA NA hsa-let-7a-3p PDE1C 0.215598045625678 0.85543299203799 0.142444975128073 0.817200412330167 mirMAP -0.390199495667006 0.00119771506029023 NA NA NA hsa-let-7a-3p PDE4B 0.215598045625678 0.85543299203799 0.41255995219071 0.621221710054517 mirMAP -0.305530135278685 0.00243742055743648 NA NA NA hsa-let-7a-3p PDE5A 0.215598045625678 0.85543299203799 0.259711639653851 0.798067018667304 MirTarget -0.249267642957443 0.00241508410636153 NA NA NA hsa-let-7a-3p PDGFC 0.215598045625678 0.85543299203799 -0.41425206316592 0.616833473868724 mirMAP -0.560183588702006 8.86071239448277e-09 NA NA NA hsa-let-7a-3p PDGFRA 0.215598045625678 0.85543299203799 0.145858107393819 0.902950557320272 mirMAP -0.46804730928802 1.13954952980613e-05 NA NA NA hsa-let-7a-3p PDZRN3 0.215598045625678 0.85543299203799 0.0178544962727245 0.984480680237247 miRNATAP -0.348332403637459 0.000447014170045025 NA NA NA hsa-let-7a-3p PEG10 0.215598045625678 0.85543299203799 -0.663369862535256 0.295187271954902 mirMAP -0.520314464992891 0.00532082958672564 NA NA NA hsa-let-7a-3p PFKFB3 0.215598045625678 0.85543299203799 -0.015136289989929 0.991328459658227 MirTarget;miRNATAP -0.113814500352109 0.0258200081232623 NA NA NA hsa-let-7a-3p PGM2L1 0.215598045625678 0.85543299203799 0.151222574866344 0.888508441726656 mirMAP -0.173772274870734 0.0115823419416568 NA NA NA hsa-let-7a-3p PHLDB2 0.215598045625678 0.85543299203799 -0.10579322871738 0.89652841418376 mirMAP -0.695794910477307 3.29681309455157e-11 NA NA NA hsa-let-7a-3p PI15 0.215598045625678 0.85543299203799 -0.319518413066792 0.559333858199035 MirTarget -0.438432944968582 0.00444793207113499 NA NA NA hsa-let-7a-3p PJA2 0.215598045625678 0.85543299203799 -0.0491913409501352 0.972311038227409 MirTarget;mirMAP -0.178462987095895 3.42605793795789e-05 NA NA NA hsa-let-7a-3p PLA2R1 0.215598045625678 0.85543299203799 -0.514625295249625 0.479095134499385 mirMAP -0.19721378029766 0.0361205241459697 NA NA NA hsa-miR-106a-5p PLCB1 0.203919267842652 0.802213958426804 -0.585724538908979 0.503249899338963 miRNATAP -0.240252663270855 0.0134533504700539 NA NA NA hsa-miR-106b-5p PLCB1 0.297128724729338 0.86929444354075 -0.585724538908979 0.503249899338963 miRNATAP -0.280100704898359 0.0128285209412543 NA NA NA hsa-miR-107 PLCB1 0.0365118169251648 0.988364120226869 -0.585724538908979 0.503249899338963 PITA;miRanda;miRNATAP -0.381491719416682 0.0209910214226876 NA NA NA hsa-miR-10a-3p PLCB1 0.0996469316906685 0.882902638592481 -0.585724538908979 0.503249899338963 miRNATAP -0.200127697909739 0.0106467864085593 NA NA NA hsa-miR-130b-3p PLCB1 0.221667315324818 0.824660172394714 -0.585724538908979 0.503249899338963 miRNATAP -0.346654626715993 0.000547199373710532 NA NA NA hsa-miR-140-3p PLCB1 0.369894078407762 0.864762211761538 -0.585724538908979 0.503249899338963 PITA -0.529575232741916 0.00196728432959414 NA NA NA hsa-miR-142-3p PLCB1 0.154235241441331 0.946098054588918 -0.585724538908979 0.503249899338963 PITA;miRanda;miRNATAP -0.172682999612616 0.0314614746955043 NA NA NA hsa-miR-16-2-3p PLCB1 0.36717860153421 0.546850726070016 -0.585724538908979 0.503249899338963 mirMAP -0.322346426435825 0.00030464248725077 NA NA NA hsa-miR-17-5p PLCB1 0.175448849583061 0.934544015912731 -0.585724538908979 0.503249899338963 TargetScan;miRNATAP -0.250067522224842 0.00345877682972104 NA NA NA hsa-miR-19a-3p PLCB1 0.206793507801887 0.844637784802316 -0.585724538908979 0.503249899338963 miRNATAP -0.230842601387747 0.00455153592697883 NA NA NA hsa-miR-20a-5p PLCB1 0.179153323927949 0.928118119139752 -0.585724538908979 0.503249899338963 miRNATAP -0.258542803923675 0.00213160010105103 NA NA NA hsa-miR-26a-1-3p PLCB1 0.429875601809349 0.182136384322617 -0.585724538908979 0.503249899338963 mirMAP -0.329886915019254 7.316451499044e-05 NA NA NA hsa-miR-26a-2-3p PLCB1 0.427772454814258 0.28776911697575 -0.585724538908979 0.503249899338963 mirMAP -0.242116000682071 0.00615186955400678 NA NA NA hsa-miR-338-5p PLCB1 -0.484769112400394 0.393961930708873 -0.585724538908979 0.503249899338963 PITA;mirMAP;miRNATAP -0.270578324175855 0.00012056197178218 NA NA NA hsa-miR-34a-5p PLCB1 0.50188164870224 0.742034237185732 -0.585724538908979 0.503249899338963 miRNATAP -0.291928197805485 0.00525758792989879 NA NA NA hsa-miR-429 PLCB1 0.456485631615963 0.806240953400535 -0.585724538908979 0.503249899338963 miRNATAP -0.191134778403374 0.0136429301833116 NA NA NA hsa-miR-548o-3p PLCB1 0.191447572716993 0.517725546183501 -0.585724538908979 0.503249899338963 mirMAP -0.217661841570445 0.0150759873075151 NA NA NA hsa-miR-577 PLCB1 1.06238199218774 0.326056761787754 -0.585724538908979 0.503249899338963 PITA;mirMAP;miRNATAP -0.117540401477771 0.0211725242954957 NA NA NA hsa-miR-590-3p PLCB1 0.27924475537686 0.591266699336619 -0.585724538908979 0.503249899338963 PITA;miRanda;mirMAP -0.293138422170019 0.000304208510341494 NA NA NA hsa-miR-590-5p PLCB1 0.547819833829572 0.472735645776647 -0.585724538908979 0.503249899338963 PITA;miRanda -0.271716680913537 0.00160597305679212 NA NA NA hsa-miR-7-1-3p PLCB1 0.462485777435991 0.665899751398166 -0.585724538908979 0.503249899338963 mirMAP -0.244474848901417 0.0107233723456149 NA NA NA hsa-miR-93-5p PLCB1 0.611073677204697 0.825297877093194 -0.585724538908979 0.503249899338963 miRNATAP -0.393348618144292 0.000191048463479506 NA NA NA hsa-miR-26b-5p PLCB2 0.0245931278499594 0.990377966314923 0.322974746305649 0.684414890068433 miRNAWalker2_validate -0.310084346427735 0.00146917450043707 NA NA NA hsa-miR-339-5p PLCB2 0.300425087100668 0.712912847076787 0.322974746305649 0.684414890068433 miRanda -0.206136918352303 0.000544998799835996 NA NA NA hsa-let-7i-5p PLCB4 0.200792135853451 0.922018647874073 -0.174334761760549 0.909370618049436 miRNATAP -0.825858998532497 0.000326482119466754 NA NA NA hsa-miR-496 PLCB4 -0.0761187951070486 0.791920800440324 -0.174334761760549 0.909370618049436 miRanda -0.249644808026237 0.0363363955245494 NA NA NA hsa-miR-590-3p PLCB4 0.27924475537686 0.591266699336619 -0.174334761760549 0.909370618049436 miRanda -0.216941657454726 0.0419318175388366 NA NA NA hsa-let-7a-3p PLCL1 0.215598045625678 0.85543299203799 -0.141101533924102 0.663424329257415 mirMAP -0.441531564239423 1.75776315087487e-09 NA NA NA hsa-let-7a-3p PLXDC1 0.215598045625678 0.85543299203799 -0.233427854443579 0.76639487227046 mirMAP -0.353676295490288 7.40749147743929e-07 NA NA NA hsa-let-7a-3p PLXNA4 0.215598045625678 0.85543299203799 -0.3237674605378 0.574611670955424 miRNATAP -0.895125888135038 5.76001265551055e-10 NA NA NA hsa-let-7a-3p POLK 0.215598045625678 0.85543299203799 0.0298737068591546 0.973824092373044 MirTarget -0.122480793478035 0.000107261754731944 NA NA NA hsa-miR-92a-3p PPARD -0.0278830870766349 0.993247426671713 -0.104039944737687 0.939285686745942 miRNAWalker2_validate -0.146082897527087 0.0001877051160926 NA NA NA hsa-let-7a-3p PPM1K 0.215598045625678 0.85543299203799 0.134469135274902 0.800295362470138 MirTarget -0.211349638742289 0.00323721678058101 NA NA NA hsa-let-7a-3p PPP1R12A 0.215598045625678 0.85543299203799 0.130366246152914 0.923496493485558 mirMAP;miRNATAP -0.112334081980534 0.000143326741796444 NA NA NA hsa-let-7a-3p PPP1R3F 0.215598045625678 0.85543299203799 -0.128631238040522 0.685792053903222 MirTarget;miRNATAP -0.193174870934325 0.0128110532450715 NA NA NA hsa-miR-143-5p PPP2CA -0.105899699238448 0.933358732923557 -0.0356851568486913 0.982479603446852 MirTarget -0.113970843387226 3.04336029101809e-06 NA NA NA hsa-miR-30a-5p PPP2CA -0.219472325612347 0.933954023293815 -0.0356851568486913 0.982479603446852 mirMAP -0.120297904871551 0.00285198820090026 NA NA NA hsa-miR-361-5p PPP2CB 0.138735309928775 0.941495130308343 0.370189087014535 0.795944489242702 miRanda -0.156216425232678 0.0219786132834804 NA NA NA hsa-miR-125a-5p PPP2R5C 0.00183986061615293 0.999158100170883 0.0416764418339994 0.979060666938947 MirTarget;PITA;miRanda -0.128116734610181 0.000513753699682629 NA NA NA hsa-miR-132-3p PPP2R5C 0.244143673573889 0.871752726220643 0.0416764418339994 0.979060666938947 miRNATAP -0.125263910265897 0.00408623818705044 NA NA NA hsa-miR-140-3p PPP2R5C 0.369894078407762 0.864762211761538 0.0416764418339994 0.979060666938947 MirTarget -0.11811951342879 0.0179457721673387 NA NA NA hsa-miR-125a-5p PPP2R5E 0.00183986061615293 0.999158100170883 0.315676038449801 0.782415509075426 miRNAWalker2_validate -0.206654538213536 2.85766790777101e-07 NA NA NA hsa-miR-130a-3p PPP2R5E -0.0910074087716906 0.929098200371948 0.315676038449801 0.782415509075426 mirMAP -0.162786000810969 3.40039221813072e-07 NA NA NA hsa-miR-181a-5p PPP2R5E -0.0295101956318309 0.989325168350124 0.315676038449801 0.782415509075426 MirTarget;mirMAP -0.127362411490184 0.000820389638518227 NA NA NA hsa-miR-181b-5p PPP2R5E -0.155313039554487 0.930176779696506 0.315676038449801 0.782415509075426 MirTarget;mirMAP -0.119994528183826 0.00120115585852406 NA NA NA hsa-miR-199a-3p PPP2R5E -0.0782166873040406 0.973766909565327 0.315676038449801 0.782415509075426 MirTarget;PITA -0.142900049123088 0.000138668354582098 NA NA NA hsa-miR-199b-3p PPP2R5E -0.0780653337513897 0.973815251150337 0.315676038449801 0.782415509075426 MirTarget;PITA;miRNATAP -0.142871028193333 0.000139104402673137 NA NA NA hsa-miR-224-3p PPP2R5E -0.110372723153393 0.749091467231007 0.315676038449801 0.782415509075426 mirMAP -0.106273069320977 1.89725476200205e-05 NA NA NA hsa-miR-23a-3p PPP2R5E 0.122198715333656 0.962717452143511 0.315676038449801 0.782415509075426 MirTarget -0.278139919171475 1.27767565860005e-06 24997345 Downregulation of PPP2R5E expression by miR 23a suppresses apoptosis to facilitate the growth of gastric cancer cells; Here we declare that PPP2R5E is downregulated by miR-23a and induces cell growth inhibition and apoptosis in gastric cancer cells; PPP2R5E is identified as a new target of miR-23a; Moreover overexpression of PPP2R5E reversed the negative effects of miR-23a; We highlight the significance of miR-23a and PPP2R5E in the proliferation and apoptosis of gastric cancer cells gastric cancer hsa-miR-23b-3p PPP2R5E 0.108222548187042 0.961352920317635 0.315676038449801 0.782415509075426 MirTarget -0.131498770120833 0.0221395578166222 NA NA NA hsa-miR-30c-5p PPP2R5E 0.298383882401475 0.865809030482001 0.315676038449801 0.782415509075426 mirMAP -0.100232774059428 0.0244122212692476 NA NA NA hsa-miR-30e-5p PPP2R5E 0.0657075181380993 0.979684509181942 0.315676038449801 0.782415509075426 mirMAP -0.121180367060616 0.0137843886214816 NA NA NA hsa-miR-323a-3p PPP2R5E -0.279126405514894 0.478782330851768 0.315676038449801 0.782415509075426 mirMAP -0.107447923933299 6.00091439116037e-05 NA NA NA hsa-miR-361-5p PPP2R5E 0.138735309928775 0.941495130308343 0.315676038449801 0.782415509075426 miRanda -0.204044613003842 0.000116825054008582 NA NA NA hsa-miR-365a-3p PPP2R5E -0.0797451871548285 0.938758494058573 0.315676038449801 0.782415509075426 miRNAWalker2_validate -0.11656185008126 0.00310912775237505 NA NA NA hsa-miR-374b-5p PPP2R5E 0.285682091626877 0.835698304799651 0.315676038449801 0.782415509075426 mirMAP -0.151025762980418 0.000517777925342188 NA NA NA hsa-miR-17-5p PPP3CA 0.175448849583061 0.934544015912731 0.0875097520345731 0.946989676888573 miRNATAP -0.109137738299345 0.000214467204408686 NA NA NA hsa-miR-29a-5p PPP3CA 0.31835175571979 0.600442757817281 0.0875097520345731 0.946989676888573 mirMAP;miRNATAP -0.110664225522305 0.000326600214856183 NA NA NA hsa-miR-335-3p PPP3CA 0.244830745789441 0.884500191166311 0.0875097520345731 0.946989676888573 MirTarget -0.158993670541163 1.48991898684692e-07 NA NA NA hsa-miR-361-5p PPP3CA 0.138735309928775 0.941495130308343 0.0875097520345731 0.946989676888573 miRanda -0.181593940934707 0.00153602268336464 NA NA NA hsa-miR-374b-3p PPP3CA 0.0542885924440243 0.860753623992355 0.0875097520345731 0.946989676888573 MirTarget -0.118414724128426 0.00147351846810998 NA NA NA hsa-miR-361-5p PPP3CB 0.138735309928775 0.941495130308343 -0.124829671662726 0.918408096293943 miRanda -0.192230575391786 6.63676765547426e-06 NA NA NA hsa-miR-421 PPP3CB 0.182032017078617 0.734704500318599 -0.124829671662726 0.918408096293943 miRanda -0.101890409493066 2.52334802788457e-05 NA NA NA hsa-miR-375 PPP3CC 0.690952835064579 0.831716365337669 0.156394846840245 0.838706340015868 miRanda -0.115145516987059 0.000311412501063658 NA NA NA hsa-miR-500a-3p PPP3CC 0.633375813338737 0.732582832733154 0.156394846840245 0.838706340015868 MirTarget;miRNATAP -0.139392380696939 0.00623176129399307 NA NA NA hsa-miR-502-3p PPP3CC 0.481234445251923 0.514301076452422 0.156394846840245 0.838706340015868 MirTarget;PITA;miRNATAP -0.136603401947088 0.0135239923652009 NA NA NA hsa-miR-143-5p PPP3R1 -0.105899699238448 0.933358732923557 0.0496199114529334 0.972488514207791 miRNATAP -0.101757134766809 6.67106697655597e-08 NA NA NA hsa-miR-27b-3p PPP3R1 0.14277121795778 0.951937409841932 0.0496199114529334 0.972488514207791 miRNATAP -0.108860558741904 0.00403865953676784 NA NA NA hsa-let-7a-3p PRDM1 0.215598045625678 0.85543299203799 -0.166919202494697 0.873410717709053 mirMAP -0.168109530894074 0.0180307506803804 20651244 Data obtained from expression analysis luciferase reporter assays and transfection experiments support a role of targeting of PRDM1 by microRNA let-7 family in mediating this down-regulation B cell lymphoma hsa-miR-141-3p PRICKLE1 0.31994058840327 0.87774106909065 -0.397606853070468 0.442555940301967 TargetScan -0.818473615751552 9.37601439666738e-23 NA NA NA hsa-miR-17-5p PRICKLE1 0.175448849583061 0.934544015912731 -0.397606853070468 0.442555940301967 miRNAWalker2_validate -0.790549265744602 1.30087431373825e-19 NA NA NA hsa-miR-192-5p PRICKLE1 0.117345487848226 0.972927287653136 -0.397606853070468 0.442555940301967 miRNAWalker2_validate -0.64728705570708 8.41829279580836e-16 NA NA NA hsa-miR-215-5p PRICKLE1 0.142648109361913 0.94480931294964 -0.397606853070468 0.442555940301967 miRNAWalker2_validate -0.33329971176339 2.65696899946024e-10 NA NA NA hsa-miR-30b-5p PRICKLE1 0.0121430518253556 0.994622896704514 -0.397606853070468 0.442555940301967 mirMAP -0.69734076944353 7.36580665370513e-12 NA NA NA hsa-miR-30c-5p PRICKLE1 0.298383882401475 0.865809030482001 -0.397606853070468 0.442555940301967 miRNATAP -0.815096477914283 4.24777573380507e-08 NA NA NA hsa-miR-30d-5p PRICKLE1 0.168211838771866 0.951731970303751 -0.397606853070468 0.442555940301967 miRNATAP -0.507159229436342 0.000199081911275133 NA NA NA hsa-miR-330-3p PRICKLE1 -0.00298687748748439 0.994504006750491 -0.397606853070468 0.442555940301967 mirMAP;miRNATAP -0.281419293799772 0.0178110531430428 NA NA NA hsa-miR-338-3p PRICKLE1 -0.491585017500118 0.78848374919419 -0.397606853070468 0.442555940301967 miRanda -0.182588341197751 0.0236879167652328 NA NA NA hsa-miR-361-5p PRICKLE1 0.138735309928775 0.941495130308343 -0.397606853070468 0.442555940301967 miRanda -0.467010606714581 0.0109998469347536 NA NA NA hsa-miR-532-5p PRICKLE1 0.349665553500088 0.878948352437467 -0.397606853070468 0.442555940301967 miRNATAP -0.54990543448667 2.0256078870021e-07 NA NA NA hsa-miR-582-5p PRICKLE1 0.399450205475138 0.581227478860085 -0.397606853070468 0.442555940301967 miRNATAP -0.691338431016561 1.10042354661321e-09 NA NA NA hsa-let-7a-3p PRICKLE2 0.215598045625678 0.85543299203799 -0.551121474925755 0.425361397476441 mirMAP -0.486808759656843 6.22651748439903e-08 NA NA NA hsa-let-7b-3p PRICKLE2 0.286212135502693 0.812160509578048 -0.551121474925755 0.425361397476441 mirMAP -0.256404740591468 0.0267670633753279 NA NA NA hsa-let-7f-1-3p PRICKLE2 0.31101436822914 0.693407210545374 -0.551121474925755 0.425361397476441 mirMAP -0.649917154187097 1.26646256542526e-07 NA NA NA hsa-let-7f-2-3p PRICKLE2 0.0455032713433074 0.882115725419367 -0.551121474925755 0.425361397476441 mirMAP -0.319627545149741 6.13882058950175e-06 NA NA NA hsa-miR-130b-5p PRICKLE2 0.6472141103776 0.379096015222509 -0.551121474925755 0.425361397476441 mirMAP -0.588881791025954 1.0028067128924e-14 NA NA NA hsa-miR-146a-5p PRICKLE2 0.581292803346902 0.736851349367572 -0.551121474925755 0.425361397476441 mirMAP -0.365062064665585 1.02874914577729e-07 NA NA NA hsa-miR-148a-3p PRICKLE2 0.101286586375016 0.976980454193186 -0.551121474925755 0.425361397476441 MirTarget;miRNATAP -0.544673899928546 3.25913699860419e-11 NA NA NA hsa-miR-148a-5p PRICKLE2 0.448099743845604 0.748419139652266 -0.551121474925755 0.425361397476441 mirMAP -0.499070979600238 3.70537808988988e-10 NA NA NA hsa-miR-148b-3p PRICKLE2 0.202106692287125 0.911884960581838 -0.551121474925755 0.425361397476441 MirTarget;miRNATAP -0.704296098796368 2.01607240594954e-09 NA NA NA hsa-miR-15b-3p PRICKLE2 0.557749208157585 0.609181305423188 -0.551121474925755 0.425361397476441 mirMAP -0.688292316856109 4.77438091036482e-18 NA NA NA hsa-miR-16-2-3p PRICKLE2 0.36717860153421 0.546850726070016 -0.551121474925755 0.425361397476441 mirMAP -0.616352235508973 3.35701580033797e-18 NA NA NA hsa-miR-182-5p PRICKLE2 0.10423849794055 0.973380614062244 -0.551121474925755 0.425361397476441 MirTarget -0.285650293085441 8.55519769941171e-05 NA NA NA hsa-miR-186-5p PRICKLE2 0.318786974828755 0.854127229389611 -0.551121474925755 0.425361397476441 MirTarget -0.760915875673251 1.07298702005099e-11 NA NA NA hsa-miR-18a-5p PRICKLE2 0.498318455303918 0.612640919755849 -0.551121474925755 0.425361397476441 MirTarget -0.383628672906702 5.72043737622555e-11 NA NA NA hsa-miR-18b-5p PRICKLE2 0.0473300652227538 0.899981261531446 -0.551121474925755 0.425361397476441 MirTarget -0.364072816443201 2.47026671417851e-10 NA NA NA hsa-miR-194-5p PRICKLE2 0.159001168846467 0.959682382557335 -0.551121474925755 0.425361397476441 miRNATAP -0.509079675776611 2.8161487802942e-12 NA NA NA hsa-miR-197-3p PRICKLE2 0.455489147957159 0.79491658209515 -0.551121474925755 0.425361397476441 mirMAP -0.49406964650522 1.99183781196082e-08 NA NA NA hsa-miR-19a-3p PRICKLE2 0.206793507801887 0.844637784802316 -0.551121474925755 0.425361397476441 MirTarget;miRNATAP -0.467250853654183 1.49129438910777e-12 NA NA NA hsa-miR-19b-3p PRICKLE2 0.0268530183621465 0.986656783046573 -0.551121474925755 0.425361397476441 MirTarget;miRNATAP -0.517502462903555 8.32610310004983e-11 NA NA NA hsa-miR-203a-3p PRICKLE2 0.265248086637561 0.931593594361942 -0.551121474925755 0.425361397476441 MirTarget -0.316999347856671 1.70155742833056e-07 NA NA NA hsa-miR-212-3p PRICKLE2 0.0224067199236493 0.973232008101457 -0.551121474925755 0.425361397476441 MirTarget;miRNATAP -0.259091990566071 0.0119456680153262 NA NA NA hsa-miR-221-5p PRICKLE2 -0.0797468413208207 0.897597103192106 -0.551121474925755 0.425361397476441 MirTarget -0.25473581546081 2.92855583247191e-05 NA NA NA hsa-miR-224-3p PRICKLE2 -0.110372723153393 0.749091467231007 -0.551121474925755 0.425361397476441 mirMAP -0.16316315709905 0.0142158747220416 NA NA NA hsa-miR-26a-1-3p PRICKLE2 0.429875601809349 0.182136384322617 -0.551121474925755 0.425361397476441 mirMAP -0.398447767042993 9.44641783902884e-09 NA NA NA hsa-miR-26a-2-3p PRICKLE2 0.427772454814258 0.28776911697575 -0.551121474925755 0.425361397476441 mirMAP -0.440107836306688 1.46362629232305e-09 NA NA NA hsa-miR-27a-3p PRICKLE2 0.123902317731458 0.958804393510999 -0.551121474925755 0.425361397476441 MirTarget;miRNATAP -0.58545033760497 8.42467607206818e-06 NA NA NA hsa-miR-27b-3p PRICKLE2 0.14277121795778 0.951937409841932 -0.551121474925755 0.425361397476441 MirTarget;miRNATAP -0.339293179395191 0.0272119540666772 NA NA NA hsa-miR-29a-3p PRICKLE2 -0.0112747441028436 0.996977020481271 -0.551121474925755 0.425361397476441 MirTarget;miRNATAP -0.637855836581901 1.69882909943348e-09 NA NA NA hsa-miR-29b-3p PRICKLE2 0.104016192263954 0.958988036765397 -0.551121474925755 0.425361397476441 MirTarget;miRNATAP -0.560356525121839 1.26483864449025e-12 NA NA NA hsa-miR-32-3p PRICKLE2 0.568003960723004 0.13133163420273 -0.551121474925755 0.425361397476441 MirTarget;mirMAP -0.448590379297521 2.32102115207005e-15 NA NA NA hsa-miR-320a PRICKLE2 0.41654643376763 0.840202138616421 -0.551121474925755 0.425361397476441 mirMAP -0.277014228434591 0.00522473269161862 NA NA NA hsa-miR-320b PRICKLE2 0.23561798088153 0.859222532827992 -0.551121474925755 0.425361397476441 mirMAP -0.246688735696225 0.00561544591888516 NA NA NA hsa-miR-320c PRICKLE2 0.577462251570141 0.113597318870228 -0.551121474925755 0.425361397476441 mirMAP -0.187541898917261 0.00438167568957247 NA NA NA hsa-miR-330-5p PRICKLE2 0.283418953659273 0.815687101334694 -0.551121474925755 0.425361397476441 miRanda;miRNATAP -0.294120638906423 0.00702002406370247 NA NA NA hsa-miR-335-3p PRICKLE2 0.244830745789441 0.884500191166311 -0.551121474925755 0.425361397476441 mirMAP -0.327998824549096 1.20869879805509e-05 NA NA NA hsa-miR-335-5p PRICKLE2 0.0284895175847679 0.973380867832231 -0.551121474925755 0.425361397476441 miRNAWalker2_validate -0.411380851679834 3.07454584358168e-08 NA NA NA hsa-miR-33a-3p PRICKLE2 0.794543849238582 0.0105203072007922 -0.551121474925755 0.425361397476441 mirMAP -0.383579402443222 2.26971748158838e-08 NA NA NA hsa-miR-33a-5p PRICKLE2 0.205788753603336 0.853314500865147 -0.551121474925755 0.425361397476441 MirTarget -0.316072164368108 1.29606125417615e-13 NA NA NA hsa-miR-33b-5p PRICKLE2 0.161971614375297 0.737436207821109 -0.551121474925755 0.425361397476441 MirTarget -0.346959554400778 2.35287835853317e-13 NA NA NA hsa-miR-361-5p PRICKLE2 0.138735309928775 0.941495130308343 -0.551121474925755 0.425361397476441 MirTarget;PITA;miRanda;miRNATAP -0.391181201112103 0.00553598024525293 NA NA NA hsa-miR-362-5p PRICKLE2 0.26647467080141 0.752024885130738 -0.551121474925755 0.425361397476441 mirMAP -0.383170665620435 7.18994745741999e-10 NA NA NA hsa-miR-374a-3p PRICKLE2 0.118320910531011 0.958176637009264 -0.551121474925755 0.425361397476441 MirTarget;miRNATAP -0.256520122440454 0.00201236442698444 NA NA NA hsa-miR-421 PRICKLE2 0.182032017078617 0.734704500318599 -0.551121474925755 0.425361397476441 miRanda -0.258468150256993 0.00113919360267716 NA NA NA hsa-miR-429 PRICKLE2 0.456485631615963 0.806240953400535 -0.551121474925755 0.425361397476441 miRNATAP -0.468418045864181 5.59928416088308e-14 NA NA NA hsa-miR-450b-5p PRICKLE2 0.0136687538973108 0.983149761399849 -0.551121474925755 0.425361397476441 MirTarget;mirMAP;miRNATAP -0.186780309804425 0.0319149905386998 NA NA NA hsa-miR-484 PRICKLE2 0.17997720269125 0.886333755572375 -0.551121474925755 0.425361397476441 miRNATAP -0.603301359999593 2.17957059056441e-09 NA NA NA hsa-miR-491-3p PRICKLE2 0.513850326596847 0.137836285146052 -0.551121474925755 0.425361397476441 MirTarget;PITA;miRNATAP -0.222924967408406 0.00134478154580176 NA NA NA hsa-miR-500a-5p PRICKLE2 0.71978560736831 0.188073776225276 -0.551121474925755 0.425361397476441 mirMAP -0.402917168509734 5.42822139945647e-09 NA NA NA hsa-miR-576-5p PRICKLE2 0.506413219377404 0.417187951364173 -0.551121474925755 0.425361397476441 mirMAP -0.610413958049022 8.31494917073662e-15 NA NA NA hsa-miR-589-3p PRICKLE2 0.835836305204965 0.0112001563801511 -0.551121474925755 0.425361397476441 MirTarget -0.330853616588062 1.71172483697326e-07 NA NA NA hsa-miR-589-5p PRICKLE2 0.448771545046784 0.722725226273464 -0.551121474925755 0.425361397476441 MirTarget;miRNATAP -0.786133046889626 5.16341882659806e-13 NA NA NA hsa-miR-590-3p PRICKLE2 0.27924475537686 0.591266699336619 -0.551121474925755 0.425361397476441 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.599810712303541 3.51870552280468e-21 NA NA NA hsa-miR-590-5p PRICKLE2 0.547819833829572 0.472735645776647 -0.551121474925755 0.425361397476441 MirTarget;PITA;miRanda -0.616868974762062 6.88998403289716e-20 NA NA NA hsa-miR-624-5p PRICKLE2 0.348001560408561 0.190596385087429 -0.551121474925755 0.425361397476441 mirMAP -0.425462959618979 1.85417661270223e-07 NA NA NA hsa-miR-629-3p PRICKLE2 0.49540274581201 0.333967382214383 -0.551121474925755 0.425361397476441 MirTarget -0.469257692569965 1.31202880017108e-13 NA NA NA hsa-miR-7-1-3p PRICKLE2 0.462485777435991 0.665899751398166 -0.551121474925755 0.425361397476441 MirTarget -0.636650559798631 5.10896150513941e-17 NA NA NA hsa-let-7a-3p PRKAA2 0.215598045625678 0.85543299203799 -1.3524018076496 0.0611671965688078 mirMAP -0.507574456403945 0.0144169189688624 NA NA NA hsa-miR-126-5p PRKACB -0.0815213541035842 0.956637332055184 -0.143826955266481 0.908097519021419 mirMAP -0.368751851213397 0.00120348231579359 NA NA NA hsa-miR-141-3p PRKACB 0.31994058840327 0.87774106909065 -0.143826955266481 0.908097519021419 MirTarget;TargetScan;miRNATAP -0.157820753550139 0.0370289083289272 NA NA NA hsa-miR-146b-5p PRKACB 0.402662509440885 0.837510937985092 -0.143826955266481 0.908097519021419 miRanda -0.384839282045274 0.000123624033577825 NA NA NA hsa-miR-16-2-3p PRKACB 0.36717860153421 0.546850726070016 -0.143826955266481 0.908097519021419 mirMAP -0.327254668787011 5.02396526650647e-05 NA NA NA hsa-miR-17-5p PRKACB 0.175448849583061 0.934544015912731 -0.143826955266481 0.908097519021419 TargetScan -0.196442682711492 0.0116051317280694 NA NA NA hsa-miR-18a-5p PRKACB 0.498318455303918 0.612640919755849 -0.143826955266481 0.908097519021419 miRNATAP -0.245987058818593 0.000136929122339416 NA NA NA hsa-miR-18b-5p PRKACB 0.0473300652227538 0.899981261531446 -0.143826955266481 0.908097519021419 miRNATAP -0.219595347623136 0.000526621294339559 NA NA NA hsa-miR-19a-3p PRKACB 0.206793507801887 0.844637784802316 -0.143826955266481 0.908097519021419 MirTarget;miRNATAP -0.207051001728292 0.00506627328237604 NA NA NA hsa-miR-19b-3p PRKACB 0.0268530183621465 0.986656783046573 -0.143826955266481 0.908097519021419 miRNAWalker2_validate;MirTarget;miRNATAP -0.187582558357789 0.0344527567559653 NA NA NA hsa-miR-32-3p PRKACB 0.568003960723004 0.13133163420273 -0.143826955266481 0.908097519021419 mirMAP;miRNATAP -0.203540155235648 0.00148647674126439 NA NA NA hsa-miR-323a-3p PRKACB -0.279126405514894 0.478782330851768 -0.143826955266481 0.908097519021419 mirMAP -0.178413271804869 0.0194885993895622 NA NA NA hsa-miR-577 PRKACB 1.06238199218774 0.326056761787754 -0.143826955266481 0.908097519021419 PITA -0.156719343600752 0.000649809465517546 NA NA NA hsa-miR-582-5p PRKACB 0.399450205475138 0.581227478860085 -0.143826955266481 0.908097519021419 MirTarget;PITA;miRNATAP -0.435642871850008 4.26493780643228e-06 NA NA NA hsa-miR-590-3p PRKACB 0.27924475537686 0.591266699336619 -0.143826955266481 0.908097519021419 MirTarget;PITA;miRanda;miRNATAP -0.287824756359109 8.97202997356946e-05 NA NA NA hsa-miR-590-5p PRKACB 0.547819833829572 0.472735645776647 -0.143826955266481 0.908097519021419 miRanda -0.269757804036837 0.000543621862271192 NA NA NA hsa-miR-7-1-3p PRKACB 0.462485777435991 0.665899751398166 -0.143826955266481 0.908097519021419 mirMAP -0.347600791347028 5.3123112509601e-05 NA NA NA hsa-let-7a-3p PRKAR2A 0.215598045625678 0.85543299203799 0.400359254658288 0.684081395451204 mirMAP -0.145915448238501 0.0139295907063592 NA NA NA hsa-let-7a-3p PRKAR2B 0.215598045625678 0.85543299203799 0.108203352456923 0.864208239994479 mirMAP -0.321301677507322 0.00677085783389006 NA NA NA hsa-miR-181c-5p PRKCA -0.0429518916606941 0.969159991881861 -0.05602398712709 0.964394422416439 mirMAP -0.137731413575932 0.0107344210501714 NA NA NA hsa-miR-24-2-5p PRKCA 0.0947200031589666 0.920155111594601 -0.05602398712709 0.964394422416439 miRNAWalker2_validate -0.134280147117741 0.0431584680189114 22911661 Preferential star strand biogenesis of pre miR 24 2 targets PKC alpha and suppresses cell survival in MCF 7 breast cancer cells poor survival breast cancer hsa-miR-29a-5p PRKCA 0.31835175571979 0.600442757817281 -0.05602398712709 0.964394422416439 mirMAP -0.131495002018621 0.00519611005738431 NA NA NA hsa-miR-340-5p PRKCA 0.00276909425328897 0.997573611610549 -0.05602398712709 0.964394422416439 mirMAP -0.127833732132063 0.0348679772659918 NA NA NA hsa-miR-369-3p PRKCA -0.116576891957687 0.83230082995912 -0.05602398712709 0.964394422416439 PITA;miRNATAP -0.120287634134684 0.0230431694957869 NA NA NA hsa-miR-450b-5p PRKCA 0.0136687538973108 0.983149761399849 -0.05602398712709 0.964394422416439 PITA;mirMAP;miRNATAP -0.165403673620787 0.00202940790109251 NA NA NA hsa-miR-141-5p PRKCB 0.354590233549885 0.867642456336402 0.289166762598653 0.629896233011358 mirMAP -0.566149586465332 2.81537724392599e-08 NA NA NA hsa-miR-148a-5p PRKCB 0.448099743845604 0.748419139652266 0.289166762598653 0.629896233011358 mirMAP -0.431607663118204 0.00014113366592115 NA NA NA hsa-miR-16-2-3p PRKCB 0.36717860153421 0.546850726070016 0.289166762598653 0.629896233011358 mirMAP -0.556524355024035 7.09185137143842e-08 NA NA NA hsa-miR-186-5p PRKCB 0.318786974828755 0.854127229389611 0.289166762598653 0.629896233011358 mirMAP -0.693684359345577 1.42561623028323e-05 NA NA NA hsa-miR-194-5p PRKCB 0.159001168846467 0.959682382557335 0.289166762598653 0.629896233011358 miRNATAP -0.642313551381144 2.93325886945843e-10 NA NA NA hsa-miR-200b-3p PRKCB 0.426401948379212 0.863957108574195 0.289166762598653 0.629896233011358 MirTarget -0.72108199701521 2.3659342346039e-11 NA NA NA hsa-miR-200c-3p PRKCB 0.437282635857873 0.887118598436407 0.289166762598653 0.629896233011358 MirTarget;miRNATAP -0.752138899288806 1.18209268005294e-11 NA NA NA hsa-miR-23a-3p PRKCB 0.122198715333656 0.962717452143511 0.289166762598653 0.629896233011358 mirMAP -0.972693790442231 3.83115244358293e-06 NA NA NA hsa-miR-24-3p PRKCB 0.0484778924256641 0.985274054814493 0.289166762598653 0.629896233011358 miRNATAP -1.14917640884554 4.29809672564759e-07 NA NA NA hsa-miR-26b-5p PRKCB 0.0245931278499594 0.990377966314923 0.289166762598653 0.629896233011358 mirMAP -0.759590158099125 4.96577614466636e-07 NA NA NA hsa-miR-27a-3p PRKCB 0.123902317731458 0.958804393510999 0.289166762598653 0.629896233011358 MirTarget;miRNATAP -0.984191959979311 4.52942226692975e-08 NA NA NA hsa-miR-29a-5p PRKCB 0.31835175571979 0.600442757817281 0.289166762598653 0.629896233011358 mirMAP -0.696324093556409 4.49269492269061e-12 NA NA NA hsa-miR-29b-1-5p PRKCB 0.642348119412534 0.293891497238796 0.289166762598653 0.629896233011358 mirMAP -0.462740943974498 6.40796306307966e-09 NA NA NA hsa-miR-30b-5p PRKCB 0.0121430518253556 0.994622896704514 0.289166762598653 0.629896233011358 mirMAP -0.662037641995433 1.55759802125021e-09 NA NA NA hsa-miR-30c-5p PRKCB 0.298383882401475 0.865809030482001 0.289166762598653 0.629896233011358 mirMAP -0.651180444056476 5.12606576516922e-05 NA NA NA hsa-miR-30d-3p PRKCB 0.123474741320297 0.814905367625793 0.289166762598653 0.629896233011358 mirMAP -0.66303716180293 1.26976276659109e-07 NA NA NA hsa-miR-30d-5p PRKCB 0.168211838771866 0.951731970303751 0.289166762598653 0.629896233011358 mirMAP -0.584797855466169 5.33137646933608e-05 NA NA NA hsa-miR-335-3p PRKCB 0.244830745789441 0.884500191166311 0.289166762598653 0.629896233011358 mirMAP -0.677283755988629 1.84838818790619e-11 NA NA NA hsa-miR-335-5p PRKCB 0.0284895175847679 0.973380867832231 0.289166762598653 0.629896233011358 mirMAP -0.675730225781425 2.5572319841088e-11 NA NA NA hsa-miR-337-3p PRKCB -0.226996212439781 0.81557585523932 0.289166762598653 0.629896233011358 mirMAP -0.293611500470901 0.0337965789712589 NA NA NA hsa-miR-361-5p PRKCB 0.138735309928775 0.941495130308343 0.289166762598653 0.629896233011358 MirTarget;miRanda;miRNATAP -0.865758986282353 6.88790498193778e-06 NA NA NA hsa-miR-429 PRKCB 0.456485631615963 0.806240953400535 0.289166762598653 0.629896233011358 MirTarget;miRanda;miRNATAP -0.619682801567495 9.47055177854519e-13 NA NA NA hsa-miR-450b-5p PRKCB 0.0136687538973108 0.983149761399849 0.289166762598653 0.629896233011358 miRNATAP -0.47287159382327 7.10615810748377e-05 NA NA NA hsa-miR-452-3p PRKCB 0.167134177977311 0.799008246175244 0.289166762598653 0.629896233011358 mirMAP -0.513101429149364 6.7170941174423e-11 NA NA NA hsa-miR-484 PRKCB 0.17997720269125 0.886333755572375 0.289166762598653 0.629896233011358 MirTarget;miRNATAP -0.612122177986842 1.70623299361676e-05 NA NA NA hsa-miR-491-5p PRKCB 0.585652105321328 0.0452620602586908 0.289166762598653 0.629896233011358 miRanda -0.35090662989035 0.000620664439809745 NA NA NA hsa-miR-502-5p PRKCB 0.708507838520586 0.0261309781860105 0.289166762598653 0.629896233011358 mirMAP -0.435593863435658 2.75280823982211e-06 NA NA NA hsa-miR-539-5p PRKCB -0.124342970087029 0.801067485473642 0.289166762598653 0.629896233011358 mirMAP -0.432505044940763 0.00059746887984469 NA NA NA hsa-miR-589-3p PRKCB 0.835836305204965 0.0112001563801511 0.289166762598653 0.629896233011358 mirMAP -0.335038959210738 0.00016508749914759 NA NA NA hsa-miR-589-5p PRKCB 0.448771545046784 0.722725226273464 0.289166762598653 0.629896233011358 mirMAP -0.565653175638186 0.000328937511746594 NA NA NA hsa-miR-590-3p PRKCB 0.27924475537686 0.591266699336619 0.289166762598653 0.629896233011358 mirMAP -0.422590592433378 8.43504361358025e-06 NA NA NA hsa-miR-590-5p PRKCB 0.547819833829572 0.472735645776647 0.289166762598653 0.629896233011358 miRanda -0.600413375866668 1.04790649499024e-09 NA NA NA hsa-miR-664a-3p PRKCB 0.00395670341813492 0.996119749372709 0.289166762598653 0.629896233011358 mirMAP -0.360108478716395 0.0126995525380586 NA NA NA hsa-miR-7-1-3p PRKCB 0.462485777435991 0.665899751398166 0.289166762598653 0.629896233011358 mirMAP -0.417430474142834 0.000191851900734184 NA NA NA hsa-miR-7-5p PRKCB -0.209645143210378 0.773705612298442 0.289166762598653 0.629896233011358 MirTarget;miRNATAP -0.205730135642304 0.0042868075722764 NA NA NA hsa-miR-335-5p PRKCG 0.0284895175847679 0.973380867832231 -0.58597015840589 0.414499065841279 miRNAWalker2_validate -0.385505309903923 0.0274513022878871 NA NA NA hsa-let-7a-3p PSD3 0.215598045625678 0.85543299203799 0.344093696549416 0.750027821944281 MirTarget;miRNATAP -0.17228385509562 0.0133993656020313 NA NA NA hsa-miR-361-5p PSEN1 0.138735309928775 0.941495130308343 -0.0284597443792292 0.98519387216101 miRanda -0.148443410758776 0.00109359287287113 NA NA NA hsa-let-7a-3p PTCH1 0.215598045625678 0.85543299203799 -0.213220757385665 0.867225589932973 MirTarget;miRNATAP -0.167705355197575 0.0281677741866561 NA NA NA hsa-let-7a-3p PTPRB 0.215598045625678 0.85543299203799 -0.0186952300714971 0.98790448412084 mirMAP -0.102797964816708 0.0225017479596649 NA NA NA hsa-let-7a-3p QKI 0.215598045625678 0.85543299203799 -0.181349489722571 0.863868934807386 mirMAP -0.509767980450145 5.19639338318079e-11 NA NA NA hsa-let-7a-3p RAB11FIP2 0.215598045625678 0.85543299203799 -0.131380491485945 0.884114377904228 MirTarget;miRNATAP -0.103182666262478 0.0269469410966921 NA NA NA hsa-let-7a-3p RAB23 0.215598045625678 0.85543299203799 -0.378006515921355 0.709653487470767 mirMAP -0.268446840071255 2.22659706281036e-07 NA NA NA hsa-let-7a-3p RAB31 0.215598045625678 0.85543299203799 -0.263592195026918 0.839893225616841 mirMAP -0.609338819826707 9.92611983432597e-10 NA NA NA hsa-let-7a-3p RAB33A 0.215598045625678 0.85543299203799 0.161141753897368 0.650894530592415 MirTarget;miRNATAP -0.293072114898934 5.38976163933812e-05 NA NA NA hsa-let-7a-3p RAB6B 0.215598045625678 0.85543299203799 -0.412074836875276 0.431397494342947 miRNATAP -0.219824543105481 0.0121361341265997 NA NA NA hsa-let-7a-3p RAB8B 0.215598045625678 0.85543299203799 0.0902950837400729 0.927903533972231 mirMAP -0.172877174339944 0.000183708230543847 NA NA NA hsa-miR-30c-2-3p RAC3 -0.242912714924037 0.746927269997556 0.189305936526801 0.723079466838888 miRNAWalker2_validate -0.284587404659289 0.00785701503311612 NA NA NA hsa-let-7a-3p RASGRF2 0.215598045625678 0.85543299203799 -0.311212456313649 0.572114180174088 mirMAP -0.28208123010843 0.00318414737558839 NA NA NA hsa-let-7a-3p RBMS3 0.215598045625678 0.85543299203799 -0.609446096219493 0.27096137757864 MirTarget -0.668266281480713 2.64894709044835e-10 NA NA NA hsa-let-7a-3p RCAN2 0.215598045625678 0.85543299203799 -0.28500256779349 0.675023925967836 miRNATAP -0.376492942341688 2.75067242193582e-06 NA NA NA hsa-let-7a-3p REST 0.215598045625678 0.85543299203799 0.292020404251502 0.722140080193392 mirMAP -0.22812336132548 1.9821952237143e-05 NA NA NA hsa-miR-361-5p RHOA 0.138735309928775 0.941495130308343 0.17248196974016 0.934600726677384 MirTarget;PITA;miRanda -0.125411234757926 0.000736149169851785 NA NA NA hsa-let-7a-3p RIC3 0.215598045625678 0.85543299203799 -0.898478990234651 0.307453136342959 mirMAP -0.984079207110811 1.60289180186838e-10 NA NA NA hsa-let-7a-3p RIMKLB 0.215598045625678 0.85543299203799 -1.01668501480441 0.0324892289861141 MirTarget -0.408368222260354 1.52776513038736e-05 NA NA NA hsa-let-7a-3p RNF144A 0.215598045625678 0.85543299203799 0.0815578157188543 0.931644974705301 MirTarget;miRNATAP -0.205790467835725 0.00568167500358189 NA NA NA hsa-let-7a-3p ROCK1 0.215598045625678 0.85543299203799 0.160229804897245 0.9001204507681 MirTarget -0.109897922952036 0.00727315012848761 NA NA NA hsa-miR-126-5p ROCK1 -0.0815213541035842 0.956637332055184 0.160229804897245 0.9001204507681 mirMAP -0.126374783815714 0.00789684731732039 27108693 MicroRNA 126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma metastasis kidney renal cell cancer hsa-miR-196b-5p ROCK1 0.0840912027031919 0.972112413910242 0.160229804897245 0.9001204507681 MirTarget -0.105486954228359 4.82675478576074e-07 NA NA NA hsa-miR-199b-5p ROCK1 0.0396557270992499 0.977172718873204 0.160229804897245 0.9001204507681 miRanda -0.106455048638711 0.00285421904884719 NA NA NA hsa-miR-335-5p ROCK1 0.0284895175847679 0.973380867832231 0.160229804897245 0.9001204507681 MirTarget -0.173047170326878 1.72899440825558e-07 25804796;23975506;27035227 MiR 335 acts as a potential tumor suppressor miRNA via downregulating ROCK1 expression in hepatocellular carcinoma; Luciferase reporter assay and Western blot were to verify ROCK1 as a novel target gene of miR-335; The expression of ROCK1 was decreased evidently after overexpression of miR-335 indicating that ROCK1 is a target gene for miR-335; Our data revealed that miR-335 could inhibit the proliferation and migration invasion of HCC cells via regulating ROCK1 suggesting that miR-335 could be a therapeutic biomarker of HCC in the future;miR 335 suppresses migration and invasion by targeting ROCK1 in osteosarcoma cells; Moreover we also showed that ROCK1 was negatively regulated by miR-335 at the posttranscriptional level via a specific target site within the 3'UTR by luciferase reporter assay; Thus our findings suggest that miR-335 acts as tumor suppressor by targeting the ROCK1 gene and inhibiting osteosarcoma cells migration and invasion;MicroRNA 335 is downregulated in bladder cancer and inhibits cell growth migration and invasion via targeting ROCK1 ;; liver cancer;sarcoma;bladder cancer hsa-miR-421 ROCK1 0.182032017078617 0.734704500318599 0.160229804897245 0.9001204507681 PITA;miRanda -0.116931197362984 0.000910505996090609 NA NA NA hsa-let-7a-3p ROCK2 0.215598045625678 0.85543299203799 0.078493111653879 0.956633941372986 mirMAP -0.126136801448212 0.0129350218758083 NA NA NA hsa-miR-126-5p ROCK2 -0.0815213541035842 0.956637332055184 0.078493111653879 0.956633941372986 mirMAP -0.248685955442308 1.89704870838048e-05 NA NA NA hsa-miR-142-3p ROCK2 0.154235241441331 0.946098054588918 0.078493111653879 0.956633941372986 PITA;miRanda;miRNATAP -0.125681145854652 0.000740862230337074 NA NA NA hsa-miR-142-5p ROCK2 0.118920788314118 0.929665277963083 0.078493111653879 0.956633941372986 PITA -0.230070984478962 9.16968002632336e-09 NA NA NA hsa-miR-340-5p ROCK2 0.00276909425328897 0.997573611610549 0.078493111653879 0.956633941372986 mirMAP -0.163993581104367 0.00216910718049147 NA NA NA hsa-miR-369-3p ROCK2 -0.116576891957687 0.83230082995912 0.078493111653879 0.956633941372986 PITA -0.159509994745788 0.000626162192050428 NA NA NA hsa-miR-582-5p ROCK2 0.399450205475138 0.581227478860085 0.078493111653879 0.956633941372986 mirMAP -0.226167385479782 3.55837392122283e-06 NA NA NA hsa-miR-590-3p ROCK2 0.27924475537686 0.591266699336619 0.078493111653879 0.956633941372986 miRanda;mirMAP -0.110309753505061 0.00384013133160484 NA NA NA hsa-let-7a-3p ROR1 0.215598045625678 0.85543299203799 -0.119420489680122 0.809980252379312 MirTarget -0.601907005323522 2.71543200071067e-05 NA NA NA hsa-let-7a-3p RORA 0.215598045625678 0.85543299203799 -0.140688699083027 0.820496084706089 MirTarget;mirMAP;miRNATAP -0.473632490078204 4.16603006656984e-08 NA NA NA hsa-let-7a-3p RSPO2 0.215598045625678 0.85543299203799 -0.368983772269747 0.660102034903145 MirTarget -0.762635763692952 2.61820243660221e-06 NA NA NA hsa-let-7a-3p RSPO3 0.215598045625678 0.85543299203799 0.0476406661621597 0.932858956355522 MirTarget -0.800681607647926 1.42716840449831e-07 NA NA NA hsa-let-7a-3p RTN1 0.215598045625678 0.85543299203799 -0.243341443283662 0.621514676767999 miRNATAP -0.580766687237098 7.91131427942045e-06 NA NA NA hsa-let-7a-3p SAMD4A 0.215598045625678 0.85543299203799 -0.0422491505547384 0.961731787304657 miRNATAP -0.37521463410034 4.30307179842972e-07 NA NA NA hsa-let-7a-3p SASH1 0.215598045625678 0.85543299203799 0.309647657405704 0.760747804513717 mirMAP -0.116088033522894 0.015872353904294 NA NA NA hsa-let-7a-3p SBNO1 0.215598045625678 0.85543299203799 0.335114099276163 0.750300085294534 mirMAP;miRNATAP -0.147666412153496 0.000618876570716609 NA NA NA hsa-let-7a-3p SCARF1 0.215598045625678 0.85543299203799 -0.111578036716099 0.859954683980397 MirTarget -0.279713097595108 9.84742805362985e-06 NA NA NA hsa-let-7a-3p SCN2A 0.215598045625678 0.85543299203799 -0.887025548315313 0.278211450537275 mirMAP;miRNATAP -0.500231659831465 0.00161336761313887 NA NA NA hsa-let-7a-3p SCN2B 0.215598045625678 0.85543299203799 -0.307007562738626 0.718115896099162 mirMAP -1.16908893514724 7.45018564788298e-12 NA NA NA hsa-let-7a-3p SCN3A 0.215598045625678 0.85543299203799 -0.29074126906627 0.625188053843657 mirMAP -0.605204530813437 8.94086897529347e-06 NA NA NA hsa-let-7a-3p SCN7A 0.215598045625678 0.85543299203799 -0.507467258259168 0.591301464696327 mirMAP -1.46177023488104 1.69731487701596e-12 NA NA NA hsa-let-7a-3p SCN9A 0.215598045625678 0.85543299203799 -0.412909163759383 0.399110278370351 mirMAP -0.946034934685484 4.41979857022062e-12 NA NA NA hsa-let-7a-3p SDC2 0.215598045625678 0.85543299203799 -0.472453527300775 0.69122997968588 MirTarget -0.537387285704146 6.69136121653752e-12 NA NA NA hsa-let-7a-3p SDK1 0.215598045625678 0.85543299203799 0.0706009772875007 0.908258166701063 mirMAP -0.340691420638116 0.0129061181996169 NA NA NA hsa-let-7a-3p SEC23A 0.215598045625678 0.85543299203799 -0.0131363504189901 0.992625650011352 MirTarget;mirMAP;miRNATAP -0.129720891756095 0.00133879198263458 NA NA NA hsa-let-7a-3p SECISBP2L 0.215598045625678 0.85543299203799 0.153406494620309 0.893839715426429 mirMAP -0.121305539658678 0.00183872046024442 NA NA NA hsa-let-7a-3p SELE 0.215598045625678 0.85543299203799 -0.121298824917122 0.831594484093126 MirTarget -0.802433056664213 4.27968481047355e-08 NA NA NA hsa-let-7a-3p SEMA3D 0.215598045625678 0.85543299203799 -0.960401354413167 0.148484346902485 mirMAP -0.901939031032647 1.46931323314417e-07 NA NA NA hsa-miR-140-3p SENP2 0.369894078407762 0.864762211761538 0.0110860053375177 0.992309888458903 mirMAP -0.103841821484027 0.00988974207295154 NA NA NA hsa-let-7a-3p SENP7 0.215598045625678 0.85543299203799 0.00725681684114221 0.992308597354811 miRNAWalker2_validate -0.122359693499163 0.00270844182567183 NA NA NA hsa-miR-1275 SFRP1 0.831342050607647 0.0803795852164229 -0.458789669044077 0.49771307771223 MirTarget -0.510540537016915 4.91642034813301e-06 NA NA NA hsa-miR-1301-3p SFRP1 0.300365313996304 0.592260761856533 -0.458789669044077 0.49771307771223 MirTarget -0.497713364758576 0.00735480617827187 NA NA NA hsa-miR-144-3p SFRP1 -0.0482420655617899 0.935871997593533 -0.458789669044077 0.49771307771223 MirTarget;miRNATAP -0.358423128968886 0.00103309540082995 NA NA NA hsa-miR-146a-5p SFRP1 0.581292803346902 0.736851349367572 -0.458789669044077 0.49771307771223 MirTarget -0.846143779831789 1.01575031051527e-08 NA NA NA hsa-miR-16-1-3p SFRP1 -0.151694812889215 0.733736501874639 -0.458789669044077 0.49771307771223 MirTarget -0.94903091584512 5.95946084903295e-10 NA NA NA hsa-miR-182-5p SFRP1 0.10423849794055 0.973380614062244 -0.458789669044077 0.49771307771223 mirMAP -0.932291865465018 1.2943599236268e-09 NA NA NA hsa-miR-192-3p SFRP1 0.182835023264087 0.910241598161435 -0.458789669044077 0.49771307771223 MirTarget -0.975123825878634 1.08283373363427e-10 NA NA NA hsa-miR-19b-1-5p SFRP1 0.0105982583216706 0.988511655226678 -0.458789669044077 0.49771307771223 MirTarget -0.919889537334065 1.25932051593181e-08 NA NA NA hsa-miR-203a-3p SFRP1 0.265248086637561 0.931593594361942 -0.458789669044077 0.49771307771223 MirTarget -0.81768716061472 2.59763257790948e-10 NA NA NA hsa-miR-26b-3p SFRP1 0.363222538866816 0.681115126930067 -0.458789669044077 0.49771307771223 MirTarget -1.17440791330659 5.91867020797149e-11 NA NA NA hsa-miR-27a-3p SFRP1 0.123902317731458 0.958804393510999 -0.458789669044077 0.49771307771223 MirTarget;miRNATAP -1.43168422415878 4.06049988636225e-07 NA NA NA hsa-miR-27b-3p SFRP1 0.14277121795778 0.951937409841932 -0.458789669044077 0.49771307771223 MirTarget;miRNATAP -0.929865113415932 0.00501191857774073 NA NA NA hsa-miR-29a-5p SFRP1 0.31835175571979 0.600442757817281 -0.458789669044077 0.49771307771223 mirMAP -1.01562407123408 1.45195577156907e-10 NA NA NA hsa-miR-30d-3p SFRP1 0.123474741320297 0.814905367625793 -0.458789669044077 0.49771307771223 miRNATAP -1.32115521540396 5.8583684537136e-12 NA NA NA hsa-miR-335-5p SFRP1 0.0284895175847679 0.973380867832231 -0.458789669044077 0.49771307771223 miRNAWalker2_validate -0.892731717727035 2.80128298274367e-08 NA NA NA hsa-miR-33a-3p SFRP1 0.794543849238582 0.0105203072007922 -0.458789669044077 0.49771307771223 MirTarget -0.858662492456339 6.73104764910375e-09 NA NA NA hsa-miR-429 SFRP1 0.456485631615963 0.806240953400535 -0.458789669044077 0.49771307771223 miRNATAP -1.24663052326811 7.35155412645914e-22 NA NA NA hsa-miR-484 SFRP1 0.17997720269125 0.886333755572375 -0.458789669044077 0.49771307771223 MirTarget -1.27634670225105 5.27114225673435e-09 NA NA NA hsa-miR-501-5p SFRP1 0.834032628506285 0.0582725160418523 -0.458789669044077 0.49771307771223 mirMAP -0.545969812548283 3.76450866815485e-05 NA NA NA hsa-miR-542-3p SFRP1 -0.188168046511374 0.909252939431573 -0.458789669044077 0.49771307771223 MirTarget;miRanda -0.488885567175617 0.026087762402302 NA NA NA hsa-miR-576-5p SFRP1 0.506413219377404 0.417187951364173 -0.458789669044077 0.49771307771223 MirTarget;PITA -1.28654170293773 5.0453153375364e-14 NA NA NA hsa-miR-625-5p SFRP1 0.690759472145278 0.210306534567564 -0.458789669044077 0.49771307771223 MirTarget -0.782794611180533 9.22876635361979e-10 NA NA NA hsa-miR-7-1-3p SFRP1 0.462485777435991 0.665899751398166 -0.458789669044077 0.49771307771223 MirTarget;mirMAP -1.12372798591865 3.02871534285669e-11 NA NA NA hsa-miR-940 SFRP1 0.225788347550697 0.680055767105815 -0.458789669044077 0.49771307771223 MirTarget -0.588765920767129 3.46674850275754e-06 NA NA NA hsa-miR-96-5p SFRP1 -0.0854810872029352 0.923087820185031 -0.458789669044077 0.49771307771223 mirMAP -1.25488507498404 1.73939520013468e-18 NA NA NA hsa-let-7a-3p SFRP2 0.215598045625678 0.85543299203799 -0.82842694262168 0.525975785137849 miRNATAP -1.19419982770431 8.44331763953112e-07 NA NA NA hsa-miR-29a-3p SFRP2 -0.0112747441028436 0.996977020481271 -0.82842694262168 0.525975785137849 miRNAWalker2_validate;miRTarBase -1.34651262952855 3.04708226426706e-06 NA NA NA hsa-miR-33a-3p SFRP2 0.794543849238582 0.0105203072007922 -0.82842694262168 0.525975785137849 miRNATAP -1.11979657385788 8.73863133317584e-10 NA NA NA hsa-miR-421 SFRP2 0.182032017078617 0.734704500318599 -0.82842694262168 0.525975785137849 miRanda -1.1574489514346 2.67789668864241e-08 NA NA NA hsa-miR-582-5p SFRP2 0.399450205475138 0.581227478860085 -0.82842694262168 0.525975785137849 miRNATAP -0.794718546768346 0.000966109549341752 NA NA NA hsa-miR-590-3p SFRP2 0.27924475537686 0.591266699336619 -0.82842694262168 0.525975785137849 miRanda -1.15812236502637 1.03785390945399e-10 NA NA NA hsa-miR-135b-5p SFRP4 -0.631573976263482 0.610028066417463 -0.570054637700394 0.641396949001081 MirTarget -0.429968210947886 0.000199377398735162 NA NA NA hsa-miR-144-5p SFRP4 0.300173463942008 0.809668168233347 -0.570054637700394 0.641396949001081 MirTarget -0.712797348021187 4.20840018189014e-08 NA NA NA hsa-miR-26b-5p SFRP4 0.0245931278499594 0.990377966314923 -0.570054637700394 0.641396949001081 miRNAWalker2_validate -1.48894213531648 1.65295312706766e-09 NA NA NA hsa-miR-375 SFRP4 0.690952835064579 0.831716365337669 -0.570054637700394 0.641396949001081 miRanda -0.77349034068892 2.67562707158269e-11 NA NA NA hsa-miR-429 SFRP4 0.456485631615963 0.806240953400535 -0.570054637700394 0.641396949001081 miRanda -1.14750864069437 4.73695906161965e-16 NA NA NA hsa-miR-532-5p SFRP4 0.349665553500088 0.878948352437467 -0.570054637700394 0.641396949001081 MirTarget -0.731145221840523 0.000109421545082678 NA NA NA hsa-miR-1254 SFRP5 0.488929355953681 0.19551794273322 -1.22233307700635 0.234281949494886 MirTarget -0.393887940236465 0.00308971845750956 NA NA NA hsa-miR-146b-5p SFRP5 0.402662509440885 0.837510937985092 -1.22233307700635 0.234281949494886 miRanda -0.768326128980126 4.78267828546294e-05 NA NA NA hsa-miR-339-5p SFRP5 0.300425087100668 0.712912847076787 -1.22233307700635 0.234281949494886 miRanda -0.339481652629107 0.0136922680832047 NA NA NA hsa-let-7a-3p SGIP1 0.215598045625678 0.85543299203799 -0.483146974589295 0.223560179623995 mirMAP -0.533562629541931 3.42331578137799e-09 NA NA NA hsa-let-7a-3p SGTB 0.215598045625678 0.85543299203799 -0.192657500228074 0.757967292261913 MirTarget;miRNATAP -0.179952674149317 0.000244799084844391 NA NA NA hsa-miR-142-3p SIAH1 0.154235241441331 0.946098054588918 -0.054033606017696 0.961532813193172 miRanda -0.10765334580304 3.68881036481584e-07 NA NA NA hsa-let-7a-3p SIX4 0.215598045625678 0.85543299203799 -1.19588599392455 0.00548735878514815 mirMAP -0.458038759009518 0.000269118586046217 NA NA NA hsa-let-7a-3p SKIL 0.215598045625678 0.85543299203799 -0.0896804203626056 0.933240597504257 mirMAP;miRNATAP -0.145226576258629 0.0208180680422029 NA NA NA hsa-miR-130a-3p SKP1 -0.0910074087716906 0.929098200371948 -0.0785624221664927 0.964224893360424 MirTarget -0.108880313437338 0.000189665521401675 NA NA NA hsa-miR-152-3p SKP1 -0.203532896690202 0.90975730233375 -0.0785624221664927 0.964224893360424 MirTarget -0.149618810294814 0.00237149821646277 NA NA NA hsa-let-7a-3p SLC18A2 0.215598045625678 0.85543299203799 0.117226388631781 0.839425938597749 MirTarget;miRNATAP -0.397815079982185 8.02557362366609e-05 NA NA NA hsa-let-7a-3p SLC1A2 0.215598045625678 0.85543299203799 0.158997851251133 0.807693689140663 miRNATAP -0.260528750461597 0.0173724424721969 NA NA NA hsa-let-7a-3p SLC6A17 0.215598045625678 0.85543299203799 -0.801465917079132 0.222288486427014 miRNATAP -0.512332473733683 3.75891754937166e-05 NA NA NA hsa-let-7a-3p SLC7A2 0.215598045625678 0.85543299203799 0.0379988302516985 0.948107807264255 MirTarget -0.465078079201533 0.00130142250465309 NA NA NA hsa-let-7a-3p SLITRK3 0.215598045625678 0.85543299203799 -1.29382000447167 0.231128299112211 miRNATAP -1.36003563551113 3.81062916330363e-15 NA NA NA hsa-miR-19b-3p SMAD2 0.0268530183621465 0.986656783046573 0.341385137878995 0.80352777577035 mirMAP -0.106199711812231 0.0122908342164241 NA NA NA hsa-miR-224-5p SMAD2 0.240425158977724 0.857351098476517 0.341385137878995 0.80352777577035 mirMAP -0.144946896100267 2.28330730309658e-06 NA NA NA hsa-miR-335-3p SMAD2 0.244830745789441 0.884500191166311 0.341385137878995 0.80352777577035 mirMAP -0.183748416593897 1.45959723247652e-06 NA NA NA hsa-miR-361-5p SMAD2 0.138735309928775 0.941495130308343 0.341385137878995 0.80352777577035 MirTarget -0.259356843450004 0.000295254093149791 NA NA NA hsa-miR-362-5p SMAD2 0.26647467080141 0.752024885130738 0.341385137878995 0.80352777577035 mirMAP -0.136859171316736 2.57672906518625e-05 NA NA NA hsa-miR-374a-3p SMAD2 0.118320910531011 0.958176637009264 0.341385137878995 0.80352777577035 mirMAP -0.102503892318377 0.0162421347520397 NA NA NA hsa-miR-374a-5p SMAD2 0.343007247142618 0.766921280269271 0.341385137878995 0.80352777577035 MirTarget -0.253649660447609 2.52056689655766e-05 NA NA NA hsa-miR-374b-5p SMAD2 0.285682091626877 0.835698304799651 0.341385137878995 0.80352777577035 MirTarget -0.229429865423688 8.85252457736708e-05 NA NA NA hsa-miR-421 SMAD2 0.182032017078617 0.734704500318599 0.341385137878995 0.80352777577035 miRanda -0.145020546518494 0.000344143197074529 NA NA NA hsa-miR-532-5p SMAD2 0.349665553500088 0.878948352437467 0.341385137878995 0.80352777577035 MirTarget -0.161763384526726 0.000125286468937968 NA NA NA hsa-miR-106a-5p SMAD4 0.203919267842652 0.802213958426804 0.473107439957933 0.714784528258548 mirMAP;miRNATAP -0.131559182838557 0.00285404554218347 NA NA NA hsa-miR-126-5p SMAD4 -0.0815213541035842 0.956637332055184 0.473107439957933 0.714784528258548 mirMAP -0.17020815706545 0.00292610435147629 NA NA NA hsa-miR-130a-3p SMAD4 -0.0910074087716906 0.929098200371948 0.473107439957933 0.714784528258548 miRNAWalker2_validate;miRNATAP -0.184401339431379 5.24541105443445e-05 NA NA NA hsa-miR-154-3p SMAD4 0.170366170038505 0.546500133020447 0.473107439957933 0.714784528258548 mirMAP -0.103309676469378 0.0166191123183206 NA NA NA hsa-miR-17-5p SMAD4 0.175448849583061 0.934544015912731 0.473107439957933 0.714784528258548 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.156039110852489 5.25398949950574e-05 NA NA NA hsa-miR-188-5p SMAD4 0.56851767054255 0.324820848307955 0.473107439957933 0.714784528258548 mirMAP -0.155102827964383 1.62558980704385e-06 NA NA NA hsa-miR-18a-5p SMAD4 0.498318455303918 0.612640919755849 0.473107439957933 0.714784528258548 miRNAWalker2_validate -0.114726944873734 0.000401136839426702 NA NA NA hsa-miR-199a-5p SMAD4 -0.157247797504494 0.935797462797012 0.473107439957933 0.714784528258548 miRNAWalker2_validate;miRTarBase;miRanda -0.124269403452512 0.0120659459177153 NA NA NA hsa-miR-199b-5p SMAD4 0.0396557270992499 0.977172718873204 0.473107439957933 0.714784528258548 miRanda -0.110082591125563 0.0106768629835122 NA NA NA hsa-miR-19a-3p SMAD4 0.206793507801887 0.844637784802316 0.473107439957933 0.714784528258548 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.128678500941526 0.000480832222870715 NA NA NA hsa-miR-19b-1-5p SMAD4 0.0105982583216706 0.988511655226678 0.473107439957933 0.714784528258548 mirMAP -0.114973355211667 0.00512532740693421 NA NA NA hsa-miR-19b-3p SMAD4 0.0268530183621465 0.986656783046573 0.473107439957933 0.714784528258548 miRNAWalker2_validate;mirMAP;miRNATAP -0.168993961293221 0.000120795994186259 NA NA NA hsa-miR-20a-3p SMAD4 -0.456808229166029 0.576740561365039 0.473107439957933 0.714784528258548 mirMAP -0.10577777067313 0.000632028096974473 27286257 MicroRNA 20a 5p promotes colorectal cancer invasion and metastasis by downregulating Smad4 metastasis colorectal cancer hsa-miR-20a-5p SMAD4 0.179153323927949 0.928118119139752 0.473107439957933 0.714784528258548 miRNAWalker2_validate;mirMAP;miRNATAP -0.135068597650963 0.000403680215106847 27286257 MicroRNA 20a 5p promotes colorectal cancer invasion and metastasis by downregulating Smad4; miR-20a-5p negatively regulated Smad4 by directly targeting its 3'UTR in human colorectal cancer cells; miR-20a-5p not only promoted CRC cells aggression capacity in vitro and liver metastasis in vivo but also promoted the epithelial-to-mesenchymal transition process by downregulating Smad4 expression; Luciferase reporter assay and transfection technique were used to validate the correlation between miR-20a-5p and Smad4 in CRC; Wound healing transwell and tumorigenesis assays were used to explore the function of miR-20a-5p and Smad4 in CRC progression in vitro and in vivo; miR-20a-5p as an onco-miRNA promoted the invasion and metastasis ability by suppressing Smad4 expression in CRC cells and high miR-20a-5p predicted poor prognosis for CRC patients providing a novel and promising therapeutic target in human colorectal cancer metastasis;progression;tumorigenesis;worse prognosis colorectal cancer hsa-miR-214-5p SMAD4 -0.0562296501933561 0.945594330093022 0.473107439957933 0.714784528258548 MirTarget -0.147056148842957 0.000874920355644155 NA NA NA hsa-miR-224-3p SMAD4 -0.110372723153393 0.749091467231007 0.473107439957933 0.714784528258548 mirMAP -0.15203159741221 1.47510559860259e-05 24817781;24152489;26187928;23913306;25804630;26307684 Increased miR-224 diminished Cdc42 and SMAD4 expressions at both the protein and mRNA levels and inhibited the formation of actin filaments;In addition the regulation of SMAD4 by miR-224 was evaluated by qRT-PCR Western blotting and luciferase reporter assays; Furthermore the over-expression of miR-224 in CRC cell lines decreased SMAD4 expression at the translational level and decreased SMAD4-driven luciferase-reporter activity;Increased miR-224 expression promotes cell migration invasion and proliferation by directly targeting the tumor suppressors TNFα-induced protein 1 TNFAIP1 and SMAD4; Up-regulated miR-224 thus facilitates tumor progression by shifting the equilibrium of the partially antagonist functions of SMAD4 and TNFAIP1 toward enhanced invasion and growth in NSCLC;Our in vitro study demonstrated that miR-224 played an oncogenic role in hepatoma cell migration and tumor formation through silencing its target gene Smad4; A noncanonical pathway links autophagy miR-224 Smad4 and HBV-associated HCC;We identified SMAD4 as a miR-224 target and observed negative correlation Spearman Rs=-0.44 p<0.0001 between SMAD4 and miR-224 expression in clinical samples; In the TCGA set combined analysis of miR-224 with SMAD4 expression enhanced correlation with survival HR 4.12 95% CI 1.1 to 15.41 p=0.0175; MiR-224 promotes CRC metastasis at least in part through the regulation of SMAD4;We further demonstrated that miR-224 functions as an oncogene in NSCLC by directly targeting TNFAIP1 and SMAD4 ;;cell migration;progression;cell migration;poor survival;metastasis; colorectal cancer;colorectal cancer;lung squamous cell cancer;liver cancer;colorectal cancer;lung cancer hsa-miR-224-5p SMAD4 0.240425158977724 0.857351098476517 0.473107439957933 0.714784528258548 miRNAWalker2_validate;miRTarBase;MirTarget -0.161750410504916 4.20843705349202e-07 24817781;24152489;26187928;23913306;25804630;26307684 Increased miR-224 diminished Cdc42 and SMAD4 expressions at both the protein and mRNA levels and inhibited the formation of actin filaments;In addition the regulation of SMAD4 by miR-224 was evaluated by qRT-PCR Western blotting and luciferase reporter assays; Furthermore the over-expression of miR-224 in CRC cell lines decreased SMAD4 expression at the translational level and decreased SMAD4-driven luciferase-reporter activity;Increased miR-224 expression promotes cell migration invasion and proliferation by directly targeting the tumor suppressors TNFα-induced protein 1 TNFAIP1 and SMAD4; Up-regulated miR-224 thus facilitates tumor progression by shifting the equilibrium of the partially antagonist functions of SMAD4 and TNFAIP1 toward enhanced invasion and growth in NSCLC;Our in vitro study demonstrated that miR-224 played an oncogenic role in hepatoma cell migration and tumor formation through silencing its target gene Smad4; A noncanonical pathway links autophagy miR-224 Smad4 and HBV-associated HCC;We identified SMAD4 as a miR-224 target and observed negative correlation Spearman Rs=-0.44 p<0.0001 between SMAD4 and miR-224 expression in clinical samples; In the TCGA set combined analysis of miR-224 with SMAD4 expression enhanced correlation with survival HR 4.12 95% CI 1.1 to 15.41 p=0.0175; MiR-224 promotes CRC metastasis at least in part through the regulation of SMAD4;We further demonstrated that miR-224 functions as an oncogene in NSCLC by directly targeting TNFAIP1 and SMAD4 ;;cell migration;progression;cell migration;poor survival;metastasis; colorectal cancer;colorectal cancer;lung squamous cell cancer;liver cancer;colorectal cancer;lung cancer hsa-miR-27a-3p SMAD4 0.123902317731458 0.958804393510999 0.473107439957933 0.714784528258548 MirTarget -0.164937026168655 0.0210406535663283 NA NA NA hsa-miR-28-5p SMAD4 0.10631945923046 0.940600125491369 0.473107439957933 0.714784528258548 miRanda;miRNATAP -0.238421795038978 0.0461669687692008 NA NA NA hsa-miR-30b-5p SMAD4 0.0121430518253556 0.994622896704514 0.473107439957933 0.714784528258548 mirMAP -0.10114613683392 0.0211395120082831 NA NA NA hsa-miR-30c-5p SMAD4 0.298383882401475 0.865809030482001 0.473107439957933 0.714784528258548 mirMAP -0.161864241902982 0.00997017208528321 NA NA NA hsa-miR-30e-5p SMAD4 0.0657075181380993 0.979684509181942 0.473107439957933 0.714784528258548 mirMAP -0.15766133803937 0.0234890029059231 NA NA NA hsa-miR-335-3p SMAD4 0.244830745789441 0.884500191166311 0.473107439957933 0.714784528258548 mirMAP -0.152108913902534 0.000161782003808618 NA NA NA hsa-miR-361-5p SMAD4 0.138735309928775 0.941495130308343 0.473107439957933 0.714784528258548 mirMAP -0.25694604812623 0.000622808366001207 NA NA NA hsa-miR-369-3p SMAD4 -0.116576891957687 0.83230082995912 0.473107439957933 0.714784528258548 mirMAP -0.129702032821106 0.00443370777607746 NA NA NA hsa-miR-374a-5p SMAD4 0.343007247142618 0.766921280269271 0.473107439957933 0.714784528258548 mirMAP -0.172312563460398 0.00687195386161141 NA NA NA hsa-miR-374b-5p SMAD4 0.285682091626877 0.835698304799651 0.473107439957933 0.714784528258548 mirMAP -0.199204180191632 0.00121736577828174 NA NA NA hsa-miR-377-3p SMAD4 0.0435868040110953 0.893514136702459 0.473107439957933 0.714784528258548 MirTarget -0.101669454382718 0.00980370784502512 NA NA NA hsa-miR-425-5p SMAD4 0.354606074344121 0.845979106734409 0.473107439957933 0.714784528258548 mirMAP -0.130531407894903 0.00133502406681675 NA NA NA hsa-miR-450b-5p SMAD4 0.0136687538973108 0.983149761399849 0.473107439957933 0.714784528258548 mirMAP -0.196219534294055 1.87736804832562e-05 NA NA NA hsa-miR-454-3p SMAD4 0.101514866328012 0.84354515825619 0.473107439957933 0.714784528258548 miRNAWalker2_validate;miRNATAP -0.168274939805476 0.00152054988480945 NA NA NA hsa-miR-493-5p SMAD4 -0.229930075372343 0.731979520100109 0.473107439957933 0.714784528258548 mirMAP -0.131277897668656 0.0169082007660858 NA NA NA hsa-miR-500a-5p SMAD4 0.71978560736831 0.188073776225276 0.473107439957933 0.714784528258548 mirMAP -0.121458878900978 0.00137356923942353 NA NA NA hsa-miR-539-5p SMAD4 -0.124342970087029 0.801067485473642 0.473107439957933 0.714784528258548 mirMAP -0.180979731505977 0.000193930709263202 NA NA NA hsa-miR-664a-5p SMAD4 -0.174801390431277 0.529208948201419 0.473107439957933 0.714784528258548 mirMAP -0.100622166021984 0.0251969905143627 NA NA NA hsa-miR-92a-3p SMAD4 -0.0278830870766349 0.993247426671713 0.473107439957933 0.714784528258548 miRNAWalker2_validate;mirMAP -0.174217160676192 0.000127132683719261 NA NA NA hsa-let-7a-3p SMAD9 0.215598045625678 0.85543299203799 0.31784766895202 0.558127392762348 mirMAP -0.316094009167273 0.0338943587613516 NA NA NA hsa-let-7a-3p SMO 0.215598045625678 0.85543299203799 -0.323680939941531 0.689148716294435 MirTarget;miRNATAP -0.290079801348381 0.0068681168303185 NA NA NA hsa-let-7a-3p SNAI1 0.215598045625678 0.85543299203799 -0.267910853815678 0.688867672194823 miRNATAP -0.240033025786024 0.000285142877263354 NA NA NA hsa-let-7a-3p SNCA 0.215598045625678 0.85543299203799 -0.463854045721414 0.313975955631073 mirMAP -0.720385331302896 3.67042774595845e-08 NA NA NA hsa-let-7a-3p SNX10 0.215598045625678 0.85543299203799 0.0342359949425446 0.968232715627858 mirMAP -0.171449218400762 0.011327645539396 NA NA NA hsa-let-7a-3p SOAT1 0.215598045625678 0.85543299203799 0.250620393603167 0.812660813970389 mirMAP -0.242494696468343 0.00127274817252281 NA NA NA hsa-let-7a-3p SORBS1 0.215598045625678 0.85543299203799 -0.411755605379787 0.750613323081535 miRNATAP -0.549759923997115 1.41757214894194e-08 NA NA NA hsa-let-7a-3p SOX11 0.215598045625678 0.85543299203799 -1.04911852270556 0.0199351056044311 miRNATAP -0.45397440057564 0.00029648452617381 NA NA NA hsa-miR-141-3p SOX17 0.31994058840327 0.87774106909065 -0.240581045871685 0.418965556479622 TargetScan -0.505272437332591 1.25420548567418e-18 22921431 Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer; MicroRNA 141 was also found to down-regulate SOX17 expression and activate the WNT signal pathway esophageal cancer hsa-miR-26b-5p SOX17 0.0245931278499594 0.990377966314923 -0.240581045871685 0.418965556479622 miRNATAP -0.448560421877652 3.02586486560545e-06 NA NA NA hsa-miR-362-3p SOX17 0.721040238345347 0.0345881362485733 -0.240581045871685 0.418965556479622 miRanda;miRNATAP -0.233525315540409 7.22889165806902e-05 NA NA NA hsa-miR-421 SOX17 0.182032017078617 0.734704500318599 -0.240581045871685 0.418965556479622 miRanda -0.309803627619118 6.95401202129939e-06 NA NA NA hsa-miR-590-3p SOX17 0.27924475537686 0.591266699336619 -0.240581045871685 0.418965556479622 miRanda;miRNATAP -0.388805234838502 2.97465992398104e-11 NA NA NA hsa-miR-590-5p SOX17 0.547819833829572 0.472735645776647 -0.240581045871685 0.418965556479622 miRanda -0.445655717411623 3.44617971274194e-13 NA NA NA hsa-let-7a-3p SOX5 0.215598045625678 0.85543299203799 -0.310978950269951 0.611470489039075 mirMAP -0.603979215157227 1.58623925623023e-07 NA NA NA hsa-let-7a-3p SPAG9 0.215598045625678 0.85543299203799 -0.124600733918807 0.931536294944665 mirMAP -0.105534351892329 0.00992592970433298 NA NA NA hsa-let-7a-3p SPATA13 0.215598045625678 0.85543299203799 -0.293097693501589 0.803837604734861 MirTarget -0.199544859185589 0.0052453142028302 NA NA NA hsa-let-7a-3p SPOCK1 0.215598045625678 0.85543299203799 -1.00166927167218 0.289030852509615 mirMAP -0.969593863431252 6.30406465475896e-09 NA NA NA hsa-let-7a-3p ST6GAL2 0.215598045625678 0.85543299203799 -1.33007836267101 0.0542670406596404 miRNATAP -0.786309258799329 9.17029512306906e-05 NA NA NA hsa-let-7a-3p ST6GALNAC3 0.215598045625678 0.85543299203799 0.396206079538374 0.240147091042313 MirTarget -0.189762184851356 0.0438332840491062 NA NA NA hsa-let-7a-3p STOX2 0.215598045625678 0.85543299203799 -0.824409455775631 0.28778776257751 mirMAP -0.600813458487328 2.87391336549032e-07 NA NA NA hsa-let-7a-3p STRN 0.215598045625678 0.85543299203799 0.0644348818967044 0.948293830134519 mirMAP -0.126098855208663 0.00584351725303666 NA NA NA hsa-let-7a-3p SV2B 0.215598045625678 0.85543299203799 -0.628739389351268 0.25798375801916 MirTarget;mirMAP -0.851499761862744 5.19032449474897e-09 NA NA NA hsa-let-7a-3p SWAP70 0.215598045625678 0.85543299203799 0.000169714667592302 0.999891304215687 MirTarget -0.107913504269791 0.00502025658568432 NA NA NA hsa-let-7a-3p SYNGR1 0.215598045625678 0.85543299203799 -0.45436145299879 0.338659997287571 miRNATAP -0.413981356621858 0.000741262075253495 NA NA NA hsa-let-7a-3p SYNJ1 0.215598045625678 0.85543299203799 -0.0758974602647906 0.919075847261696 mirMAP -0.103886225479171 0.006824677407815 NA NA NA hsa-let-7a-3p TACC1 0.215598045625678 0.85543299203799 0.0527088852105733 0.973502363382417 MirTarget;mirMAP -0.161509215240318 0.0127804368541417 NA NA NA hsa-let-7a-3p TANC2 0.215598045625678 0.85543299203799 0.22856752071956 0.78633176987161 miRNATAP -0.316356949763268 0.00136839751467035 NA NA NA hsa-let-7a-3p TAOK1 0.215598045625678 0.85543299203799 0.00511870860271202 0.995099673202883 MirTarget;miRNATAP -0.289186206275419 5.69874760925919e-06 NA NA NA hsa-let-7a-3p TBC1D2B 0.215598045625678 0.85543299203799 0.146923164396162 0.915195079377329 MirTarget -0.141556969391109 0.000677700801648851 NA NA NA hsa-let-7a-3p TBCEL 0.215598045625678 0.85543299203799 0.0732531967319074 0.919506087322031 mirMAP -0.262157472929308 1.13526525457887e-05 NA NA NA hsa-miR-192-5p TBL1X 0.117345487848226 0.972927287653136 0.138862312849977 0.905839452340651 miRNAWalker2_validate -0.109646847389953 0.0413156859642786 NA NA NA hsa-miR-20a-3p TBL1X -0.456808229166029 0.576740561365039 0.138862312849977 0.905839452340651 MirTarget;miRNATAP -0.106581546490978 0.024388871671204 NA NA NA hsa-miR-30c-1-3p TBL1X 0.202466672579761 0.511485842123022 0.138862312849977 0.905839452340651 MirTarget -0.127616768593415 0.0286961008760276 NA NA NA hsa-miR-335-5p TBL1X 0.0284895175847679 0.973380867832231 0.138862312849977 0.905839452340651 miRNAWalker2_validate -0.124121362340922 0.0459675532767656 NA NA NA hsa-miR-539-5p TBL1X -0.124342970087029 0.801067485473642 0.138862312849977 0.905839452340651 mirMAP -0.157707806471486 0.0343303153146916 NA NA NA hsa-miR-552-3p TBL1X -0.172135417326457 0.893972136172393 0.138862312849977 0.905839452340651 MirTarget -0.11586445243707 0.000275016300053242 NA NA NA hsa-miR-92a-3p TBL1X -0.0278830870766349 0.993247426671713 0.138862312849977 0.905839452340651 miRNAWalker2_validate;mirMAP -0.187523741777201 0.00706483083410881 NA NA NA hsa-miR-93-3p TBL1X 0.438355548962673 0.549902689385444 0.138862312849977 0.905839452340651 mirMAP -0.140635064876856 0.0323584331677041 NA NA NA hsa-let-7a-3p TCF4 0.215598045625678 0.85543299203799 -0.192390157965161 0.858432875854638 mirMAP;miRNATAP -0.485159264019734 1.23111192976066e-09 NA NA NA hsa-miR-215-5p TCF7 0.142648109361913 0.94480931294964 -0.423582866808512 0.74688431641332 miRNAWalker2_validate;MirTarget -0.113272334004619 0.00078883184611383 NA NA NA hsa-miR-106a-5p TCF7L1 0.203919267842652 0.802213958426804 -0.402717210708942 0.479661024937114 MirTarget -0.21691074540819 5.98128103884481e-05 NA NA NA hsa-miR-106b-5p TCF7L1 0.297128724729338 0.86929444354075 -0.402717210708942 0.479661024937114 MirTarget -0.412207115212278 9.54365057247493e-12 NA NA NA hsa-miR-130b-5p TCF7L1 0.6472141103776 0.379096015222509 -0.402717210708942 0.479661024937114 MirTarget -0.430096414874045 3.34739484224554e-18 NA NA NA hsa-miR-141-3p TCF7L1 0.31994058840327 0.87774106909065 -0.402717210708942 0.479661024937114 miRNAWalker2_validate -0.389033714201084 1.55531817646511e-19 NA NA NA hsa-miR-15b-3p TCF7L1 0.557749208157585 0.609181305423188 -0.402717210708942 0.479661024937114 miRNATAP -0.452339426428614 8.00077498147628e-18 NA NA NA hsa-miR-17-5p TCF7L1 0.175448849583061 0.934544015912731 -0.402717210708942 0.479661024937114 MirTarget;TargetScan -0.339876699903084 9.56782264800795e-14 NA NA NA hsa-miR-185-3p TCF7L1 -0.100697585937245 0.856913315942984 -0.402717210708942 0.479661024937114 MirTarget -0.296594224756213 7.44596441436389e-08 NA NA NA hsa-miR-200a-3p TCF7L1 0.36703443744091 0.851059894150264 -0.402717210708942 0.479661024937114 miRNAWalker2_validate -0.326465298240901 3.19723425626494e-14 NA NA NA hsa-miR-200b-3p TCF7L1 0.426401948379212 0.863957108574195 -0.402717210708942 0.479661024937114 miRNAWalker2_validate -0.399103284306769 2.79238660952596e-15 NA NA NA hsa-miR-200c-3p TCF7L1 0.437282635857873 0.887118598436407 -0.402717210708942 0.479661024937114 miRNAWalker2_validate -0.456660723450383 3.42232996019783e-19 NA NA NA hsa-miR-20a-5p TCF7L1 0.179153323927949 0.928118119139752 -0.402717210708942 0.479661024937114 MirTarget -0.326990829611436 4.20690649775668e-13 NA NA NA hsa-miR-30b-3p TCF7L1 0.514644352757503 0.162424853398397 -0.402717210708942 0.479661024937114 MirTarget -0.174144109162913 0.00106959143964259 NA NA NA hsa-miR-30d-3p TCF7L1 0.123474741320297 0.814905367625793 -0.402717210708942 0.479661024937114 miRNATAP -0.389219323366683 3.77571986631102e-11 NA NA NA hsa-miR-330-5p TCF7L1 0.283418953659273 0.815687101334694 -0.402717210708942 0.479661024937114 miRanda -0.269034351012755 0.000169924948942531 NA NA NA hsa-miR-362-3p TCF7L1 0.721040238345347 0.0345881362485733 -0.402717210708942 0.479661024937114 miRanda;miRNATAP -0.145155275233058 0.00113678308619884 NA NA NA hsa-miR-429 TCF7L1 0.456485631615963 0.806240953400535 -0.402717210708942 0.479661024937114 miRNAWalker2_validate -0.307353177790098 9.01368010301532e-14 NA NA NA hsa-miR-455-3p TCF7L1 0.35634168171146 0.824635754440662 -0.402717210708942 0.479661024937114 MirTarget;PITA;miRNATAP -0.199039470590073 1.28390243824511e-05 NA NA NA hsa-miR-505-5p TCF7L1 0.555858818875454 0.317679205488749 -0.402717210708942 0.479661024937114 miRNATAP -0.172159223594929 0.00156319164765094 NA NA NA hsa-miR-590-3p TCF7L1 0.27924475537686 0.591266699336619 -0.402717210708942 0.479661024937114 PITA;miRanda;miRNATAP -0.27937911706307 2.83048341888801e-10 NA NA NA hsa-miR-93-5p TCF7L1 0.611073677204697 0.825297877093194 -0.402717210708942 0.479661024937114 MirTarget -0.496656931304449 1.80732700371685e-19 NA NA NA hsa-miR-181a-5p TCF7L2 -0.0295101956318309 0.989325168350124 0.181990807545402 0.892393784585701 MirTarget;miRNATAP -0.115680012819849 0.01368779966919 NA NA NA hsa-miR-181c-5p TCF7L2 -0.0429518916606941 0.969159991881861 0.181990807545402 0.892393784585701 MirTarget;miRNATAP -0.182504714347455 4.52985731683706e-06 NA NA NA hsa-miR-181d-5p TCF7L2 -0.14926527647499 0.888000971478017 0.181990807545402 0.892393784585701 MirTarget -0.147785025284075 2.08206281204787e-06 NA NA NA hsa-miR-217 TCF7L2 -0.341080669095095 0.760998144794467 0.181990807545402 0.892393784585701 MirTarget;miRanda;miRNATAP -0.131869664076788 3.56283866566372e-06 NA NA NA hsa-miR-328-3p TCF7L2 0.270905420573709 0.758001839490037 0.181990807545402 0.892393784585701 MirTarget -0.130013349047585 0.0022585586655471 27181358 microRNA 328 inhibits cervical cancer cell proliferation and tumorigenesis by targeting TCF7L2; Bioinformatic analysis predicted TCF7L2 an essential effector of canonical Wnt signaling as a target gene of miR-328 which was confirmed by luciferase reporter assays; Enforced expression of miR-328 led to a decline in the expression of endogenous TCF7L2 in cervical cancer cells; In cervical cancer tissues TCF7L2 protein levels were negatively correlated with miR-328 expression levels r = -0.462 P = 0.017; Taken together our results provide first evidence for the growth suppressive activity of miR-328 in cervical cancer which is largely ascribed to downregulation of TCF7L2 tumorigenesis cervical and endocervical cancer hsa-let-7a-3p TGFB2 0.215598045625678 0.85543299203799 -0.566877582921752 0.302981050441314 miRNATAP -0.509553196595548 1.6994890144512e-07 NA NA NA hsa-let-7a-3p TGFB3 0.215598045625678 0.85543299203799 -0.290973928352886 0.724980713991106 MirTarget -0.683864247335398 2.32084912745715e-08 NA NA NA hsa-let-7a-3p THBS1 0.215598045625678 0.85543299203799 -0.37603535083018 0.836094799366458 mirMAP -0.41118832969956 1.17692621132587e-05 NA NA NA hsa-let-7a-3p THRB 0.215598045625678 0.85543299203799 -0.138527169759115 0.845219678691709 MirTarget;miRNATAP -0.400415971983236 0.0123572935862353 NA NA NA hsa-let-7a-3p TIGD7 0.215598045625678 0.85543299203799 -0.363765287758234 0.418981090079936 MirTarget -0.134676015029932 0.0457749902014921 NA NA NA hsa-let-7a-3p TIMP3 0.215598045625678 0.85543299203799 -0.272535353217297 0.875945966100811 mirMAP;miRNATAP -0.563983933485885 3.38295067591527e-08 NA NA NA hsa-let-7a-3p TMEM117 0.215598045625678 0.85543299203799 -0.216137538432447 0.765500858033818 MirTarget -0.100519492361723 0.0368637962813297 NA NA NA hsa-let-7a-3p TMEM132B 0.215598045625678 0.85543299203799 0.0381201799998294 0.949996672125388 MirTarget;mirMAP -0.254945344153406 0.0409725279334021 NA NA NA hsa-let-7a-3p TMEM170B 0.215598045625678 0.85543299203799 -0.333682820829085 0.558771589276883 mirMAP -0.250384584704787 0.00833089284383446 NA NA NA hsa-let-7a-3p TMEM55A 0.215598045625678 0.85543299203799 -0.671792660286306 0.352816780139513 mirMAP -0.264708609367674 0.000364895268581335 NA NA NA hsa-let-7a-3p TMEM67 0.215598045625678 0.85543299203799 -0.134053364245885 0.836918295257275 mirMAP -0.141331834638967 0.0153204522639449 NA NA NA hsa-let-7a-3p TMOD2 0.215598045625678 0.85543299203799 0.252563233382165 0.728524307256317 mirMAP -0.266207433424316 0.00207876822599063 NA NA NA hsa-let-7a-3p TMTC1 0.215598045625678 0.85543299203799 0.300705878590891 0.635518788125398 mirMAP -0.533559295310267 1.09388046356749e-07 NA NA NA hsa-let-7a-3p TNFSF4 0.215598045625678 0.85543299203799 -0.182023652211546 0.756253863968517 mirMAP -0.6031567130705 1.98374132385316e-09 NA NA NA hsa-let-7a-3p TNS3 0.215598045625678 0.85543299203799 -0.0864097406444362 0.958910555670206 MirTarget;miRNATAP -0.182528797969579 0.000133674800820745 NA NA NA hsa-let-7a-3p TP53INP1 0.215598045625678 0.85543299203799 0.267582057335208 0.792290697704368 mirMAP -0.169031080495452 0.00302201494963528 NA NA NA hsa-let-7a-3p TPM1 0.215598045625678 0.85543299203799 0.238013037896684 0.901652760108728 miRNATAP -0.11201705669995 0.0425223987585866 NA NA NA hsa-let-7a-3p TRIM23 0.215598045625678 0.85543299203799 -0.0397601404264067 0.952616691138422 mirMAP -0.118501029903296 0.000702279606183227 NA NA NA hsa-let-7a-3p TRIM6 0.215598045625678 0.85543299203799 -0.24842797638355 0.442261047032017 MirTarget -0.411820384024677 4.39281463602545e-06 NA NA NA hsa-let-7a-3p TSHZ3 0.215598045625678 0.85543299203799 -0.129985323559052 0.836247940567881 MirTarget;miRNATAP -0.526063836522617 4.16978571271738e-09 NA NA NA hsa-let-7a-3p TSLP 0.215598045625678 0.85543299203799 -0.726704638299737 0.185704172998583 MirTarget -0.262798462419184 0.0222441996565428 NA NA NA hsa-let-7a-3p TSPAN2 0.215598045625678 0.85543299203799 -0.43607640284819 0.542083619963739 MirTarget;mirMAP -0.717468335534669 8.96447798532594e-11 NA NA NA hsa-let-7a-3p TTC30A 0.215598045625678 0.85543299203799 -0.423721929358191 0.514944799173043 MirTarget;mirMAP -0.147584979486919 0.0216971619930343 NA NA NA hsa-let-7a-3p TWIST1 0.215598045625678 0.85543299203799 -0.899099890233358 0.0527150533734855 MirTarget;miRNATAP -0.391095138990491 0.000702044457713798 21352471 Knocking down IL-6 and Twist in HSCs significantly reduced let-7 and miR-181 expression and subsequently inhibited chemoresistance and cell invasion drug resistance liver cancer hsa-let-7a-3p TXLNG 0.215598045625678 0.85543299203799 0.0796284413203274 0.929686053520924 miRNATAP -0.165775727515694 0.00359007667292489 NA NA NA hsa-let-7a-3p UBE2Q2 0.215598045625678 0.85543299203799 0.305360029612571 0.799150008108755 MirTarget -0.132437117047085 0.00357275548358816 NA NA NA hsa-let-7a-3p UHMK1 0.215598045625678 0.85543299203799 0.164968720740987 0.858074697700844 MirTarget;mirMAP -0.220061554496429 0.00133827679658503 NA NA NA hsa-let-7a-3p UNC5C 0.215598045625678 0.85543299203799 0.0321177554593055 0.957063280613962 MirTarget -0.577848896779087 1.14966666159459e-05 NA NA NA hsa-let-7a-3p USP12 0.215598045625678 0.85543299203799 -0.241898856184349 0.818007629845927 MirTarget;mirMAP;miRNATAP -0.191377132639697 0.0013327442535865 NA NA NA hsa-let-7a-3p UTRN 0.215598045625678 0.85543299203799 0.308367595840808 0.822351953343179 mirMAP;miRNATAP -0.13255439345061 0.0382389294911218 NA NA NA hsa-let-7a-5p VANGL2 0.0620211756550386 0.985006886285189 -0.770212725792587 0.428663186498278 TargetScan;miRNATAP -0.533012122214758 0.0230290071694065 NA NA NA hsa-let-7f-5p VANGL2 -0.0487899170347212 0.987280455481632 -0.770212725792587 0.428663186498278 miRNATAP -0.419272329831199 0.0354405133085208 NA NA NA hsa-let-7g-3p VANGL2 0.489638373791484 0.62941522205833 -0.770212725792587 0.428663186498278 miRNATAP -0.242902151652262 0.0271078726418323 NA NA NA hsa-let-7i-5p VANGL2 0.200792135853451 0.922018647874073 -0.770212725792587 0.428663186498278 miRNATAP -0.580799506124246 0.0129003266951414 NA NA NA hsa-miR-107 VANGL2 0.0365118169251648 0.988364120226869 -0.770212725792587 0.428663186498278 miRanda -0.807781900082149 0.00016788703446867 NA NA NA hsa-miR-128-3p VANGL2 0.442192625156042 0.783886533572187 -0.770212725792587 0.428663186498278 MirTarget -0.770108272633921 2.20660721465527e-06 NA NA NA hsa-miR-140-3p VANGL2 0.369894078407762 0.864762211761538 -0.770212725792587 0.428663186498278 PITA;miRNATAP -0.647747992178188 0.00395685282883934 NA NA NA hsa-miR-146b-3p VANGL2 0.408862981477662 0.76252054047886 -0.770212725792587 0.428663186498278 PITA -0.50552073600027 0.000239723916823666 NA NA NA hsa-miR-15b-3p VANGL2 0.557749208157585 0.609181305423188 -0.770212725792587 0.428663186498278 mirMAP -0.401999984080657 0.00229347543247302 NA NA NA hsa-miR-185-5p VANGL2 0.294432218239008 0.820591478398594 -0.770212725792587 0.428663186498278 MirTarget -0.947618694049307 7.69631125196326e-08 NA NA NA hsa-miR-186-5p VANGL2 0.318786974828755 0.854127229389611 -0.770212725792587 0.428663186498278 mirMAP -0.55364799391336 0.00208700934239534 NA NA NA hsa-miR-33a-3p VANGL2 0.794543849238582 0.0105203072007922 -0.770212725792587 0.428663186498278 miRNATAP -0.223654685389098 0.0403539937151845 NA NA NA hsa-miR-378a-5p VANGL2 0.559739196974497 0.724882066659501 -0.770212725792587 0.428663186498278 MirTarget -0.584327633917235 5.88352893260458e-06 NA NA NA hsa-miR-511-5p VANGL2 0.308591187445275 0.607200373476563 -0.770212725792587 0.428663186498278 MirTarget -0.278595050357348 0.0130823064042119 NA NA NA hsa-miR-582-3p VANGL2 0.2334649592375 0.897678119160318 -0.770212725792587 0.428663186498278 mirMAP -0.804371500108253 5.63987309154999e-10 NA NA NA hsa-miR-582-5p VANGL2 0.399450205475138 0.581227478860085 -0.770212725792587 0.428663186498278 PITA;miRNATAP -0.690340717676146 4.03305116081449e-07 NA NA NA hsa-miR-589-3p VANGL2 0.835836305204965 0.0112001563801511 -0.770212725792587 0.428663186498278 mirMAP -0.4339142568251 1.04748945058037e-05 NA NA NA hsa-miR-589-5p VANGL2 0.448771545046784 0.722725226273464 -0.770212725792587 0.428663186498278 mirMAP -1.03377046370619 1.42124169834202e-09 NA NA NA hsa-miR-590-3p VANGL2 0.27924475537686 0.591266699336619 -0.770212725792587 0.428663186498278 miRanda -0.361471944680754 0.000701950705597688 NA NA NA hsa-miR-7-1-3p VANGL2 0.462485777435991 0.665899751398166 -0.770212725792587 0.428663186498278 mirMAP -0.399774420919523 0.00140377240024295 NA NA NA hsa-let-7a-3p VCAM1 0.215598045625678 0.85543299203799 -0.0978860903861953 0.915366682659125 MirTarget -0.565513015032381 6.46540861917718e-09 NA NA NA hsa-let-7a-3p VCAN 0.215598045625678 0.85543299203799 -0.490160174937991 0.752814460471298 MirTarget -0.66133735766405 6.15130939932976e-10 NA NA NA hsa-let-7a-3p VGLL3 0.215598045625678 0.85543299203799 -0.563513970800339 0.368080030112004 mirMAP -0.701491053872918 7.20353470099627e-09 NA NA NA hsa-let-7a-3p VPS13B 0.215598045625678 0.85543299203799 0.0225497577847502 0.984132427430548 mirMAP -0.144493231992925 0.00131898873216244 NA NA NA hsa-let-7a-3p WASF3 0.215598045625678 0.85543299203799 -0.916370793328291 0.12427057620594 miRNATAP -0.636332770829483 4.48877831221663e-05 NA NA NA hsa-let-7a-3p WDFY3 0.215598045625678 0.85543299203799 0.161194044591024 0.889336566259291 mirMAP;miRNATAP -0.143439986169561 3.35597865117766e-05 NA NA NA hsa-let-7a-3p WDR44 0.215598045625678 0.85543299203799 0.0784490145741987 0.936258989404307 mirMAP -0.102987187259596 0.0143440786006533 NA NA NA hsa-let-7a-3p WDR47 0.215598045625678 0.85543299203799 0.011241359236184 0.98849530205582 mirMAP -0.140022638552815 3.96076742297845e-05 NA NA NA hsa-miR-140-3p WIF1 0.369894078407762 0.864762211761538 -3.12129939931488 0.00672337737058921 PITA;miRNATAP -1.21449670840685 0.00961626522437693 NA NA NA hsa-miR-320a WIF1 0.41654643376763 0.840202138616421 -3.12129939931488 0.00672337737058921 miRanda -0.634642634231846 0.0473201805555562 NA NA NA hsa-miR-320b WIF1 0.23561798088153 0.859222532827992 -3.12129939931488 0.00672337737058921 miRanda -0.6291352386917 0.028386018353539 NA NA NA hsa-miR-330-5p WIF1 0.283418953659273 0.815687101334694 -3.12129939931488 0.00672337737058921 miRanda -1.0602726241873 0.00242528794989799 NA NA NA hsa-miR-342-3p WIF1 0.371626144515113 0.77313668985267 -3.12129939931488 0.00672337737058921 miRanda -0.540872467340896 0.0466768032176563 NA NA NA hsa-miR-590-3p WIF1 0.27924475537686 0.591266699336619 -3.12129939931488 0.00672337737058921 PITA;miRanda;mirMAP -0.469561506499811 0.0360269342815174 NA NA NA hsa-miR-19a-3p WNT10A 0.206793507801887 0.844637784802316 -1.2947270954084 0.00683452748884356 MirTarget -0.280344560866448 0.00716394186440647 NA NA NA hsa-miR-19b-3p WNT10A 0.0268530183621465 0.986656783046573 -1.2947270954084 0.00683452748884356 MirTarget -0.309565008555973 0.0131577954956965 NA NA NA hsa-miR-378a-3p WNT10A 0.466787210598085 0.795055970353024 -1.2947270954084 0.00683452748884356 MirTarget;miRNATAP -0.809623599709609 1.68920044926608e-09 NA NA NA hsa-miR-429 WNT10A 0.456485631615963 0.806240953400535 -1.2947270954084 0.00683452748884356 miRNATAP -0.248430856781165 0.0122465575775466 NA NA NA hsa-miR-188-5p WNT10B 0.56851767054255 0.324820848307955 0.136941296597211 0.797128731906648 PITA -0.18652733064587 0.0306204979930474 NA NA NA hsa-miR-335-5p WNT10B 0.0284895175847679 0.973380867832231 0.136941296597211 0.797128731906648 miRNAWalker2_validate -0.255457976774964 0.0167658846140517 NA NA NA hsa-miR-320a WNT11 0.41654643376763 0.840202138616421 -0.846684604893891 0.327218753036276 miRanda -0.425705540607936 0.0295885751937362 NA NA NA hsa-miR-320b WNT11 0.23561798088153 0.859222532827992 -0.846684604893891 0.327218753036276 miRanda -0.483289474025952 0.0057861641086482 NA NA NA hsa-miR-590-3p WNT11 0.27924475537686 0.591266699336619 -0.846684604893891 0.327218753036276 miRanda -0.393195454255055 0.00396388290763855 NA NA NA hsa-let-7f-2-3p WNT2 0.0455032713433074 0.882115725419367 0.192152888155767 0.80294757941918 MirTarget -0.31367220718444 0.000142400795929771 NA NA NA hsa-miR-324-5p WNT2 0.50063248413014 0.537416710557032 0.192152888155767 0.80294757941918 miRanda -0.404913499355749 5.75064761167337e-05 NA NA NA hsa-miR-362-3p WNT2 0.721040238345347 0.0345881362485733 0.192152888155767 0.80294757941918 miRanda -0.255418262791256 0.00108695919289387 NA NA NA hsa-miR-577 WNT2 1.06238199218774 0.326056761787754 0.192152888155767 0.80294757941918 mirMAP -0.268129452381093 4.12459242014742e-08 NA NA NA hsa-miR-590-3p WNT2 0.27924475537686 0.591266699336619 0.192152888155767 0.80294757941918 miRanda;mirMAP -0.444773305200754 1.33937644848683e-08 NA NA NA hsa-miR-624-5p WNT2 0.348001560408561 0.190596385087429 0.192152888155767 0.80294757941918 MirTarget -0.284532111230919 0.00320950928771027 NA NA NA hsa-miR-125a-3p WNT2B -0.14689780893708 0.724764670752407 0.195424109020966 0.588361255800061 miRanda -0.147582488012951 0.0428473865096705 NA NA NA hsa-miR-130b-3p WNT2B 0.221667315324818 0.824660172394714 0.195424109020966 0.588361255800061 MirTarget -0.411446493536916 9.35087433257479e-06 NA NA NA hsa-miR-186-5p WNT2B 0.318786974828755 0.854127229389611 0.195424109020966 0.588361255800061 mirMAP -0.464159719190634 0.000272355594684683 NA NA NA hsa-miR-301a-3p WNT2B 0.10531251190177 0.831686745977346 0.195424109020966 0.588361255800061 MirTarget -0.24078108892737 0.0023935532988976 NA NA NA hsa-miR-32-3p WNT2B 0.568003960723004 0.13133163420273 0.195424109020966 0.588361255800061 mirMAP -0.340317399528653 1.37992605748722e-07 NA NA NA hsa-miR-429 WNT2B 0.456485631615963 0.806240953400535 0.195424109020966 0.588361255800061 miRNATAP -0.188547746324961 0.00911550819171564 NA NA NA hsa-miR-454-3p WNT2B 0.101514866328012 0.84354515825619 0.195424109020966 0.588361255800061 MirTarget -0.260703816257549 0.017204277581641 NA NA NA hsa-miR-576-5p WNT2B 0.506413219377404 0.417187951364173 0.195424109020966 0.588361255800061 mirMAP -0.394145786131296 1.28809135783959e-05 NA NA NA hsa-let-7a-3p WNT5A 0.215598045625678 0.85543299203799 -0.110395814147504 0.914533916034386 miRNATAP -0.232925679293252 0.0170186134518784 NA NA NA hsa-miR-141-3p WNT5A 0.31994058840327 0.87774106909065 -0.110395814147504 0.914533916034386 TargetScan -0.200256432563993 0.00734521574657962 NA NA NA hsa-miR-142-3p WNT5A 0.154235241441331 0.946098054588918 -0.110395814147504 0.914533916034386 miRanda -0.187899116765242 0.00904321421713111 NA NA NA hsa-miR-155-5p WNT5A 0.407235807706004 0.828669616718496 -0.110395814147504 0.914533916034386 miRNAWalker2_validate;mirMAP -0.223479064174965 0.0100269233130603 NA NA NA hsa-miR-15b-3p WNT5A 0.557749208157585 0.609181305423188 -0.110395814147504 0.914533916034386 mirMAP -0.221389918917531 0.0146260962614135 NA NA NA hsa-miR-16-2-3p WNT5A 0.36717860153421 0.546850726070016 -0.110395814147504 0.914533916034386 MirTarget;mirMAP -0.294711224902512 0.000237971109061575 NA NA NA hsa-miR-16-5p WNT5A -0.0135949734723564 0.994476223855607 -0.110395814147504 0.914533916034386 miRNAWalker2_validate -0.346963132050484 0.000435924342023163 NA NA NA hsa-miR-186-5p WNT5A 0.318786974828755 0.854127229389611 -0.110395814147504 0.914533916034386 miRNAWalker2_validate;mirMAP;miRNATAP -0.28029705299746 0.0236594250190561 NA NA NA hsa-miR-2110 WNT5A 0.317803483266315 0.250981343062022 -0.110395814147504 0.914533916034386 MirTarget -0.232380496146916 0.00643379925097321 NA NA NA hsa-miR-26a-5p WNT5A -0.00698202897992672 0.997719986197022 -0.110395814147504 0.914533916034386 mirMAP;miRNATAP -0.43112925552939 0.0117714745357199 24972966 MiR 26a inhibits prostate cancer progression by repression of Wnt5a; It was predicted that Wnt5a was a potential target gene of miR-26a by bioinformatics analysis; Then luciferase assay and Western blot analysis identified that Wnt5a was a new direct target gene of miR-26a and miR-26a inhibited prostate cancer progression via Wnt5a; Altogether the findings suggested that miR-26a may function as a tumor suppressor in prostate cancer by targeting Wnt5a progression prostate cancer hsa-miR-26b-5p WNT5A 0.0245931278499594 0.990377966314923 -0.110395814147504 0.914533916034386 mirMAP;miRNATAP -0.509082056076659 1.15546257563017e-05 NA NA NA hsa-miR-29a-5p WNT5A 0.31835175571979 0.600442757817281 -0.110395814147504 0.914533916034386 mirMAP -0.407216737734173 2.20425129530399e-07 NA NA NA hsa-miR-30b-5p WNT5A 0.0121430518253556 0.994622896704514 -0.110395814147504 0.914533916034386 mirMAP -0.298279258206302 0.00052297416246863 NA NA NA hsa-miR-30c-5p WNT5A 0.298383882401475 0.865809030482001 -0.110395814147504 0.914533916034386 mirMAP -0.417687486836998 0.000711235673044307 NA NA NA hsa-miR-30d-3p WNT5A 0.123474741320297 0.814905367625793 -0.110395814147504 0.914533916034386 mirMAP -0.266459105337685 0.00655468873705503 NA NA NA hsa-miR-30e-5p WNT5A 0.0657075181380993 0.979684509181942 -0.110395814147504 0.914533916034386 mirMAP -0.585909749322998 1.49944496326228e-05 NA NA NA hsa-miR-32-3p WNT5A 0.568003960723004 0.13133163420273 -0.110395814147504 0.914533916034386 mirMAP -0.253231752844851 5.83856141848488e-05 NA NA NA hsa-miR-374b-5p WNT5A 0.285682091626877 0.835698304799651 -0.110395814147504 0.914533916034386 MirTarget;miRNATAP -0.323060205878665 0.0081531705977795 NA NA NA hsa-miR-429 WNT5A 0.456485631615963 0.806240953400535 -0.110395814147504 0.914533916034386 miRanda;miRNATAP -0.152725876638874 0.0285789786607927 NA NA NA hsa-miR-576-5p WNT5A 0.506413219377404 0.417187951364173 -0.110395814147504 0.914533916034386 mirMAP -0.174057716560717 0.0491829992381461 NA NA NA hsa-miR-577 WNT5A 1.06238199218774 0.326056761787754 -0.110395814147504 0.914533916034386 mirMAP;miRNATAP -0.14481253749716 0.00149232098483259 NA NA NA hsa-miR-590-3p WNT5A 0.27924475537686 0.591266699336619 -0.110395814147504 0.914533916034386 miRanda;mirMAP;miRNATAP -0.291267105119937 6.18332465631002e-05 NA NA NA hsa-miR-7-1-3p WNT5A 0.462485777435991 0.665899751398166 -0.110395814147504 0.914533916034386 mirMAP -0.221136131681664 0.010236400177481 NA NA NA hsa-miR-185-5p WNT5B 0.294432218239008 0.820591478398594 -0.491055180051108 0.357654560612429 miRNAWalker2_validate -0.639977601759009 3.71646674746466e-07 NA NA NA hsa-miR-106b-5p WNT7B 0.297128724729338 0.86929444354075 -0.579474423316968 0.320796252982003 mirMAP -0.404352219519167 0.0201459219638777 NA NA NA hsa-miR-1275 WNT7B 0.831342050607647 0.0803795852164229 -0.579474423316968 0.320796252982003 MirTarget -0.387011416230313 3.97032686658408e-05 NA NA NA hsa-miR-30c-5p WNT7B 0.298383882401475 0.865809030482001 -0.579474423316968 0.320796252982003 miRNATAP -0.609277220928699 0.00419481010924774 NA NA NA hsa-miR-30d-5p WNT7B 0.168211838771866 0.951731970303751 -0.579474423316968 0.320796252982003 miRNATAP -0.442018834028284 0.021434451254707 NA NA NA hsa-miR-335-5p WNT7B 0.0284895175847679 0.973380867832231 -0.579474423316968 0.320796252982003 miRNAWalker2_validate -0.734733101983856 5.31852216140117e-08 NA NA NA hsa-miR-491-5p WNT7B 0.585652105321328 0.0452620602586908 -0.579474423316968 0.320796252982003 mirMAP -0.409843426261441 0.00236577186287215 NA NA NA hsa-let-7a-3p WNT9A 0.215598045625678 0.85543299203799 0.153288538485221 0.811910238707686 mirMAP -0.60525455253825 2.36092027856041e-06 NA NA NA hsa-let-7a-5p WNT9A 0.0620211756550386 0.985006886285189 0.153288538485221 0.811910238707686 TargetScan -0.568486505273013 0.0080880571890765 NA NA NA hsa-let-7f-1-3p WNT9A 0.31101436822914 0.693407210545374 0.153288538485221 0.811910238707686 mirMAP -1.0981342306459 1.51256643998465e-10 NA NA NA hsa-miR-1226-3p WNT9A 0.346825224699346 0.341199987121208 0.153288538485221 0.811910238707686 mirMAP -0.367979637626545 8.58417655024235e-05 NA NA NA hsa-miR-1227-3p WNT9A 0.540231719582615 0.107637783836089 0.153288538485221 0.811910238707686 mirMAP -0.342367584962106 0.000195356108595552 NA NA NA hsa-miR-148a-3p WNT9A 0.101286586375016 0.976980454193186 0.153288538485221 0.811910238707686 mirMAP -0.727159860797041 4.81139328883011e-10 NA NA NA hsa-miR-148b-3p WNT9A 0.202106692287125 0.911884960581838 0.153288538485221 0.811910238707686 mirMAP -1.03824120135403 3.54388608600412e-10 NA NA NA hsa-miR-15a-5p WNT9A 0.0674049094129137 0.964835434214122 0.153288538485221 0.811910238707686 mirMAP -1.00838814485289 6.08146492384368e-14 NA NA NA hsa-miR-15b-5p WNT9A 0.272614787130879 0.870965418321879 0.153288538485221 0.811910238707686 mirMAP -0.788885072703751 8.94472879251289e-10 NA NA NA hsa-miR-16-5p WNT9A -0.0135949734723564 0.994476223855607 0.153288538485221 0.811910238707686 mirMAP -0.883328197188995 3.2849457106567e-12 NA NA NA hsa-miR-185-3p WNT9A -0.100697585937245 0.856913315942984 0.153288538485221 0.811910238707686 mirMAP -0.477594137876954 6.62786909341971e-05 NA NA NA hsa-miR-193a-3p WNT9A 0.247265785363731 0.654363581941635 0.153288538485221 0.811910238707686 mirMAP -0.370112102920161 0.000772158605117855 NA NA NA hsa-miR-32-5p WNT9A 0.0599326761911891 0.95297595159496 0.153288538485221 0.811910238707686 mirMAP -0.717387367647511 9.24418428665514e-11 NA NA NA hsa-miR-331-3p WNT9A 0.40204226129616 0.670588911553668 0.153288538485221 0.811910238707686 mirMAP -0.509120952690381 4.87286430113257e-05 NA NA NA hsa-miR-335-5p WNT9A 0.0284895175847679 0.973380867832231 0.153288538485221 0.811910238707686 miRNAWalker2_validate -0.718753005182524 3.00490464793997e-12 NA NA NA hsa-miR-424-5p WNT9A -0.247080963500745 0.870154571783569 0.153288538485221 0.811910238707686 mirMAP -0.375571816715529 0.000119556541853369 NA NA NA hsa-miR-532-3p WNT9A 0.496590111092322 0.682889021782544 0.153288538485221 0.811910238707686 mirMAP -0.683784250002974 1.75153006152263e-11 NA NA NA hsa-miR-589-3p WNT9A 0.835836305204965 0.0112001563801511 0.153288538485221 0.811910238707686 mirMAP -0.485995950011792 5.23330245294823e-08 NA NA NA hsa-miR-96-5p WNT9A -0.0854810872029352 0.923087820185031 0.153288538485221 0.811910238707686 mirMAP -0.642828847170393 3.29804586928251e-11 NA NA NA hsa-let-7a-3p WWC2 0.215598045625678 0.85543299203799 -0.645336334106087 0.404182702675895 MirTarget;mirMAP -0.403741294087971 8.842283255666e-06 NA NA NA hsa-let-7a-3p WWC3 0.215598045625678 0.85543299203799 0.0328981495792382 0.979019431460161 mirMAP;miRNATAP -0.131448511223817 0.0112558361401624 NA NA NA hsa-let-7a-3p YAP1 0.215598045625678 0.85543299203799 -0.179309895473723 0.911777421085036 mirMAP -0.106604091569295 0.0140318250567238 NA NA NA hsa-let-7a-3p ZBTB33 0.215598045625678 0.85543299203799 0.0054296679689303 0.996487675128608 mirMAP -0.104867805390396 0.00476169534845874 NA NA NA hsa-let-7a-3p ZDHHC20 0.215598045625678 0.85543299203799 -0.322793309316616 0.749039332822113 MirTarget -0.233972836014403 0.000283904456581389 NA NA NA hsa-let-7a-3p ZFHX4 0.215598045625678 0.85543299203799 -1.01692400169439 0.0674504963597852 MirTarget;mirMAP;miRNATAP -0.966204959970826 6.73087920040218e-10 NA NA NA hsa-let-7a-3p ZFP37 0.215598045625678 0.85543299203799 0.0485077455547814 0.888975072657041 MirTarget;mirMAP -0.215414685083716 0.0316846597320217 NA NA NA hsa-let-7a-3p ZFPM2 0.215598045625678 0.85543299203799 -0.742299019060891 0.0758242652106066 miRNATAP -0.774062071253718 1.03403848304052e-11 NA NA NA hsa-let-7a-3p ZMAT3 0.215598045625678 0.85543299203799 0.325283318095947 0.503935903211142 mirMAP -0.340319811934054 2.22466728931602e-06 NA NA NA hsa-let-7a-3p ZNF304 0.215598045625678 0.85543299203799 -0.368806630797024 0.438394021800033 miRNATAP -0.329490447415152 0.00413244775039895 NA NA NA hsa-let-7a-3p ZNF415 0.215598045625678 0.85543299203799 -0.96761364155934 0.0293903081035027 MirTarget -0.371890350126686 0.00320975913772423 NA NA NA hsa-let-7a-3p ZNF43 0.215598045625678 0.85543299203799 -0.822489944933206 0.19038982565997 MirTarget -0.35304798470617 0.0172391610861445 NA NA NA hsa-let-7a-3p ZNF430 0.215598045625678 0.85543299203799 -0.00945678408838679 0.987163634746474 MirTarget -0.11490738772109 0.00277100172306204 NA NA NA hsa-let-7a-3p ZNF521 0.215598045625678 0.85543299203799 -0.203162111920262 0.718425379900782 miRNATAP -0.626984515237434 1.6953693929401e-10 NA NA NA hsa-let-7a-3p ZNF532 0.215598045625678 0.85543299203799 -0.0558301018956397 0.957554912526643 MirTarget;miRNATAP -0.410727464288442 4.20596503789465e-08 NA NA NA hsa-let-7a-3p ZNF569 0.215598045625678 0.85543299203799 -0.494474365435388 0.161059440465172 MirTarget -0.201769095645988 0.0393120848556083 NA NA NA hsa-let-7a-3p ZNF791 0.215598045625678 0.85543299203799 0.102734706826033 0.88913302711399 mirMAP -0.112693099798969 0.00120677770149597 NA NA NA hsa-let-7a-3p ZNF831 0.215598045625678 0.85543299203799 0.848039684743757 0.0933008530159748 mirMAP -0.451126745423381 0.000990557107904353 NA NA NA hsa-let-7a-3p ZSCAN12 0.215598045625678 0.85543299203799 -0.328731191279471 0.594916195267367 mirMAP -0.166693562077404 0.00588391664976962 NA NA NA