miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-34a-5p	ACSL4	1.9016323452565	1.43092834643601e-14	-0.411111056706694	0.0792024620124044	miRNAWalker2_validate;MirTarget;miRNATAP	-0.128213325285489	0.0039931548042601		NA	NA	NA
hsa-miR-34a-5p	ADAM22	1.9016323452565	1.43092834643601e-14	-1.1208957204799	0.0258901538153152	MirTarget;miRNATAP	-0.32258929423001	0.000752607872842454		NA	NA	NA
hsa-miR-34a-5p	ADAMTS2	1.9016323452565	1.43092834643601e-14	-0.765859613535112	0.157626581795504	MirTarget	-0.533315763603956	1.700855856725e-07		NA	NA	NA
hsa-miR-34a-5p	ADARB1	1.9016323452565	1.43092834643601e-14	-1.92780468757935	3.75403498492562e-10	miRNAWalker2_validate	-0.484223275855852	4.71093023246375e-17		NA	NA	NA
hsa-miR-34a-5p	AFAP1L2	1.9016323452565	1.43092834643601e-14	0.0579969442179609	0.858094386575771	miRNAWalker2_validate	-0.177083707722149	0.00405690553043548		NA	NA	NA
hsa-miR-34a-5p	AFF4	1.9016323452565	1.43092834643601e-14	-0.822203744881362	6.4795364730311e-08	miRNATAP	-0.107337753829631	0.000239606228511106		NA	NA	NA
hsa-miR-34a-5p	AHNAK	1.9016323452565	1.43092834643601e-14	-1.65511086697194	9.68769934496862e-10	miRNAWalker2_validate	-0.299986348556079	6.84179254462737e-09		NA	NA	NA
hsa-miR-34a-5p	AKAP13	1.9016323452565	1.43092834643601e-14	-1.14731602724292	2.3511548631978e-13	mirMAP	-0.205865784904102	5.97230605691576e-12		NA	NA	NA
hsa-miR-34a-5p	AKAP6	1.9016323452565	1.43092834643601e-14	-3.34363666302702	7.99165625683913e-15	MirTarget	-0.911486762786373	6.30919728561791e-31		NA	NA	NA
hsa-miR-34a-5p	ALCAM	1.9016323452565	1.43092834643601e-14	-0.727096079165627	0.0564724669785303	MirTarget;miRNATAP	-0.178273936302345	0.0141825384017939		NA	NA	NA
hsa-miR-34a-5p	ALDH1L2	1.9016323452565	1.43092834643601e-14	-1.11718715083506	0.024476208144821	MirTarget	-0.665220566906835	5.64312376217526e-13		NA	NA	NA
hsa-miR-34a-5p	AMOTL2	1.9016323452565	1.43092834643601e-14	-1.01147657574476	0.000152881926388237	MirTarget	-0.313272387060572	4.52925033838338e-10		NA	NA	NA
hsa-miR-34a-5p	ANK2	1.9016323452565	1.43092834643601e-14	-4.31721795702785	2.30783903904989e-14	MirTarget;miRNATAP	-0.918196061538051	9.9431973788018e-18		NA	NA	NA
hsa-miR-34a-5p	ANP32B	1.9016323452565	1.43092834643601e-14	0.0656649567967937	0.670726855548961	miRNATAP	-0.11570029220005	7.13017612382934e-05		NA	NA	NA
hsa-miR-34a-5p	AP1S2	1.9016323452565	1.43092834643601e-14	-1.3126608153732	9.8644272412276e-09	MirTarget	-0.427285958036978	2.11669116324457e-24		NA	NA	NA
hsa-miR-34a-5p	AR	1.9016323452565	1.43092834643601e-14	-3.30120233642072	7.57858237760738e-07	MirTarget	-0.285552437081945	0.0268278531005963	24349627;22347519;21343391;25920548;25797256;23145211	In this study we found loss of miR-34a which targets AR in PCa tissue specimens especially in patients with higher Gleason grade tumors consistent with increased expression of AR; Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed reexpression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens; PCa cells treated with BR-DIM and 5-aza-dC resulted in the demethylation of miR-34a promoter concomitant with inhibition of AR and PSA expression in LNCaP and C4-2B cells; These results suggest for the first time epigenetic silencing of miR-34a in PCa which could be reversed by BR-DIM treatment and thus BR-DIM could be useful for the inactivation of AR in the treatment of PCa.This corrects the article on p;In this study we found loss of miR-34a which targets AR in PCa tissue specimens especially in patients with higher Gleason grade tumors consistent with increased expression of AR; Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed re-expression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens; PCa cells treated with BR-DIM and 5-aza-dC resulted in the demethylation of miR-34a promoter concomitant with inhibition of AR and PSA expression in LNCaP and C4-2B cells;In particular analysis of clinical prostate cancers confirmed a negative correlation of miR-34a and miR-34c expression with AR levels;To explore further the possible role of miRNAs in the AR pathway LNCaP cell line was treated with 5α-dihydrotestosterone and flutamide showing alteration in miRNAs expression especially miR-34a which was significantly underexpressed after treatment with high doses of 5α-dihydrotestosterone; Our data support a role for miRNAs especially miR-371 and miR-34a in the complex disarrangement of AR signaling pathway and in the behavior of PC;Repression of miR-34a a known AR-targeting miRNA contributes AR expression by XRN1;Inactivation of AR and Notch 1 signaling by miR 34a attenuates prostate cancer aggressiveness; We found that over-expression of miR-34a led to reduced expression of AR PSA and Notch-1; These findings suggest that the loss of miR-34a is directly linked with up-regulation of AR and Notch-1 both of which are highly expressed in PCa and thus finding innovative approaches by which miR-34a expression could be up-regulated will have a huge impact on the treatment of PCa especially for the treatment of mCRPC	;;;;;	prostate cancer;prostate cancer;prostate cancer;prostate cancer;prostate cancer;prostate cancer
hsa-miR-34a-5p	ARHGAP1	1.9016323452565	1.43092834643601e-14	-0.882266671503522	1.75389981751782e-09	miRNAWalker2_validate;MirTarget;miRNATAP	-0.176208226939718	2.42050605259084e-10		NA	NA	NA
hsa-miR-34a-5p	ASB1	1.9016323452565	1.43092834643601e-14	-0.87000981136547	1.63208206880833e-08	MirTarget;miRNATAP	-0.163788034088971	2.36991613382301e-08		NA	NA	NA
hsa-miR-34a-5p	ASTN1	1.9016323452565	1.43092834643601e-14	-2.34091357321142	2.35607881846946e-05	MirTarget	-0.252055030665196	0.0179657654863931		NA	NA	NA
hsa-miR-34a-5p	ASXL2	1.9016323452565	1.43092834643601e-14	-0.51451006623666	0.0933931654074008	MirTarget	-0.273330572468759	2.31955299766335e-06		NA	NA	NA
hsa-miR-34a-5p	AXIN2	1.9016323452565	1.43092834643601e-14	-1.6986287186272	5.56904404371908e-05	miRNAWalker2_validate;miRTarBase	-0.316389522899683	8.52056660674017e-05	23624843	p53 regulates nuclear GSK 3 levels through miR 34 mediated Axin2 suppression in colorectal cancer cells; Exogenous miR-34a decreases Axin2 UTR-reporter activity through multiple binding sites within the 5' and 3' UTR of Axin2; Further RNA transcripts of miR-34 target were correlated with Axin2 in clinical data set of colorectal cancer patients		colorectal cancer
hsa-miR-34a-5p	AXL	1.9016323452565	1.43092834643601e-14	-1.77455438864263	3.15266913146372e-06	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.539584011595936	3.50099212266538e-14	26667302;21814748;25895459	Negative feedback regulation of AXL by miR 34a modulates apoptosis in lung cancer cells; To clarify the role of miRNAs in this regulation loop approaches using bioinformatics and molecular techniques were applied revealing that miR-34a may target the 3' UTR of AXL mRNA to inhibit AXL expression; Therefore we propose that AXL is autoregulated by miR-34a in a feedback loop; this may provide a novel opportunity for developing AXL-targeted anticancer therapies;We identified human miR-34a expression as being >3-fold down from its median expression value across all cell lines in MDA-MB-231 cells and identified AXL as a putative mRNA target using multiple miRNA/target prediction algorithms; In reporter assays miR-34a binds to its putative target site within the AXL 3'UTR to inhibit luciferase expression; Finally we present an inverse correlative trend in miR-34a and AXL expression for both cell line and patient tumor samples;MiR 34a suppresses ovarian cancer proliferation and motility by targeting AXL; Overexpression of miR-34a led to the inhibition of AXL expression indicating that AXL is a target gene for miR-34a; Our data suggest that miR-34a may function as a tumor suppressor through repression of oncogenic AXL in ovarian cancer	;;motility	lung cancer;breast cancer;ovarian cancer
hsa-miR-34a-5p	BCL2	1.9016323452565	1.43092834643601e-14	-2.02088083891464	5.5300725103229e-13	miRNAWalker2_validate;miRTarBase	-0.313298897109154	6.78995714898249e-09	24565525;23155233;24444609;20687223;22623155;24988056;18803879;19714243;25053345;20433755;21399894;22964582;23862748	In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression	drug resistance;;poor survival;drug resistance;;;poor survival;differentiation;poor survival;drug resistance;;;;	breast cancer;glioblastoma;lung squamous cell cancer;prostate cancer;breast cancer;gastric cancer;gastric cancer;pancreatic cancer;prostate cancer;colon cancer;breast cancer;lung cancer;liver cancer
hsa-miR-34a-5p	BIRC3	1.9016323452565	1.43092834643601e-14	-1.14878434773067	0.00715931622274468	miRNAWalker2_validate	-0.217054924716933	0.00780122048146313		NA	NA	NA
hsa-miR-34a-5p	BMP1	1.9016323452565	1.43092834643601e-14	0.194918683355282	0.453370270266782	mirMAP	-0.153976655186265	0.00180202470782668		NA	NA	NA
hsa-miR-34a-5p	BNC2	1.9016323452565	1.43092834643601e-14	-2.95176911794991	3.46014802400024e-09	miRNATAP	-0.803483970077456	6.98511511249094e-18		NA	NA	NA
hsa-miR-34a-5p	C17orf51	1.9016323452565	1.43092834643601e-14	-0.678914258700408	0.0225411911064938	mirMAP	-0.246693819299922	1.19469908365641e-05		NA	NA	NA
hsa-miR-34a-5p	C1orf21	1.9016323452565	1.43092834643601e-14	-1.50529673423141	7.359521051655e-11	mirMAP	-0.221569550392997	6.54300469611722e-07		NA	NA	NA
hsa-miR-34a-5p	C3orf70	1.9016323452565	1.43092834643601e-14	-2.59753933038565	1.30307841273813e-11	miRNATAP	-0.465045502913128	2.53133610277102e-10		NA	NA	NA
hsa-miR-34a-5p	C6orf106	1.9016323452565	1.43092834643601e-14	-0.158081433754432	0.269139026322449	miRNATAP	-0.104320486580289	0.000111240295496594		NA	NA	NA
hsa-miR-34a-5p	CACHD1	1.9016323452565	1.43092834643601e-14	-1.73365174141046	9.53428068425233e-07	MirTarget	-0.405935802364935	1.40008147843004e-09		NA	NA	NA
hsa-miR-34a-5p	CACNA1C	1.9016323452565	1.43092834643601e-14	-2.53203105122136	8.2041496030931e-11	MirTarget	-0.482930202130142	8.6203015431497e-11		NA	NA	NA
hsa-miR-34a-5p	CALD1	1.9016323452565	1.43092834643601e-14	-2.4663455628847	1.26294093745705e-11	miRNAWalker2_validate	-0.73446754089701	2.61417639108455e-28		NA	NA	NA
hsa-miR-34a-5p	CAMK2B	1.9016323452565	1.43092834643601e-14	0.669901839915794	0.194250472530958	mirMAP	-0.262724875681621	0.00749431352388259		NA	NA	NA
hsa-miR-34a-5p	CAPN6	1.9016323452565	1.43092834643601e-14	-3.47799832819863	8.37155036573641e-07	miRNATAP	-0.829522644500449	5.55498523422973e-10		NA	NA	NA
hsa-miR-34a-5p	CCDC50	1.9016323452565	1.43092834643601e-14	-0.784992887432969	4.78414891397232e-08	miRNATAP	-0.180304418748497	3.00267538143733e-11		NA	NA	NA
hsa-miR-34a-5p	CD44	1.9016323452565	1.43092834643601e-14	-0.796526651909205	0.0427559627960533	miRNAWalker2_validate;miRTarBase	-0.275230949000913	0.000227008858457591	25572695;24423412;25551284;25044638;21240262;26231042;27497057;23314380	The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;Furthermore we identified CD44 as being targeted by miR-34a in MIBC cells following cisplatin treatment and increased CD44 expression could efficiently reverse the effect of miR-34a on MIBC cell proliferation colongenic potential and chemosensitivity; Cisplatin-based chemotherapy induced demethylation of miR-34a promoter and increased miR-34a expression which in turn sensitized MIBC cells to cisplatin and decreased the tumorigenicity and proliferation of cancer cells that by reducing the production of CD44;MicroRNA 34a functions as an anti metastatic microRNA and suppresses angiogenesis in bladder cancer by directly targeting CD44; In this study we focus on it that microRNA-34a functions as an anti-metastatic microRNA and suppress angiogenesis in bladder cancer by directly targeting CD44; Our study defines a major metastasis and angiogenesis suppressive role for mir-34a a microRNA functions as a tumor suppressor in bladder cancer by directly targeting CD44 which would be helpful as a therapeutic approach to block bladder cancer metastasis;Nanocomplex-assisted delivery of miR-34a induces cell apoptosis and suppresses migration proliferation and tumor growth of breast cancer cells via targeting CD44 and a Notch-1-signaling pathway;The microRNA miR 34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44; We identified and validated CD44 as a direct and functional target of miR-34a and found that CD44 knockdown phenocopied miR-34a overexpression in inhibiting prostate cancer regeneration and metastasis;Registered report: the microRNA miR 34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44; Tumors with exogenous miR-34a showed reduced levels of CD44 expression Figure 4A and mutation of two putative miR-34a binding sites in the CD33 3' UTR partially abrogated signal repression in a luciferase assay Figure 4D;Nanovesicle mediated systemic delivery of microRNA 34a for CD44 overexpressing gastric cancer stem cell therapy; MicroRNA-34a miR-34a is a promising candidate for CD44 repression-based cancer therapy as it has been reported to inhibit proliferation metastasis and survival of CD44-positive CSCs; Here we used nanovesicles containing PLI/miR complexes NVs/miR to systemically deliver miR-34a and induce miR-34a-triggered CD44 suppression in orthotopically and subcutaneously implanted tumors in nude mice;miR 34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44; The ectopic overexpression of miR-34a significantly inhibited the migration and invasive ability of osteosarcoma cells by repressing the expression of CD44; These data suggest that miR-34a plays a tumor suppressor role in the metastasis of osteosarcoma cells by repressing the expression of CD44; Therefore it can be concluded that through the inhibition of CD44 expression levels miR-34a plays a significant role in the migration and invasion of osteosarcoma cells	;;metastasis;;metastasis;metastasis;metastasis;poor survival;metastasis	bladder cancer;bladder cancer;bladder cancer;breast cancer;prostate cancer;prostate cancer;gastric cancer;sarcoma
hsa-miR-34a-5p	CD47	1.9016323452565	1.43092834643601e-14	-0.164318188512451	0.480797231316326	miRNATAP	-0.203358997192752	3.63715466188499e-06		NA	NA	NA
hsa-miR-34a-5p	CDC5L	1.9016323452565	1.43092834643601e-14	-0.0133441796456699	0.914544114469139	miRNAWalker2_validate	-0.100913470803353	1.56476782258644e-05		NA	NA	NA
hsa-miR-34a-5p	CDK6	1.9016323452565	1.43092834643601e-14	-0.774202349805119	0.064787030605636	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.519263514540718	3.07288169543583e-11	21702042;26104764	Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004	;	bladder cancer;lung cancer
hsa-miR-34a-5p	CDKN1C	1.9016323452565	1.43092834643601e-14	-1.44787932669971	3.93876960323515e-05	miRNATAP	-0.28214470568661	2.69554466730922e-05		NA	NA	NA
hsa-miR-34a-5p	CDKN2C	1.9016323452565	1.43092834643601e-14	0.22688212352847	0.433133415352322	miRNAWalker2_validate	-0.218709270480303	6.47001667111707e-05		NA	NA	NA
hsa-miR-34a-5p	CDON	1.9016323452565	1.43092834643601e-14	-2.61239140080419	3.20760880328893e-10	miRNAWalker2_validate	-0.693223749816722	3.67879872744414e-19		NA	NA	NA
hsa-miR-34a-5p	CEBPB	1.9016323452565	1.43092834643601e-14	-0.382621335741301	0.125827051478291	miRNAWalker2_validate	-0.105777754494497	0.0263195601731794		NA	NA	NA
hsa-miR-34a-5p	CELF2	1.9016323452565	1.43092834643601e-14	-3.04719737979328	4.72041352009215e-15	miRNATAP	-0.628325647050444	1.66190482356385e-17		NA	NA	NA
hsa-miR-34a-5p	CEP170	1.9016323452565	1.43092834643601e-14	-0.105046872769039	0.582677978132971	miRNAWalker2_validate	-0.249779327152147	1.69932832800405e-12		NA	NA	NA
hsa-miR-34a-5p	CHM	1.9016323452565	1.43092834643601e-14	-0.349502164366627	0.0224735256043546	MirTarget	-0.148031868106474	2.70948541597197e-07		NA	NA	NA
hsa-miR-34a-5p	CKAP5	1.9016323452565	1.43092834643601e-14	0.469620409267754	0.00244089758745052	miRNAWalker2_validate	-0.113657621045968	0.000110533355229431		NA	NA	NA
hsa-miR-34a-5p	CLOCK	1.9016323452565	1.43092834643601e-14	-0.505287121256611	0.0368861017220651	MirTarget	-0.199150446873461	1.3679454059243e-05		NA	NA	NA
hsa-miR-34a-5p	CNST	1.9016323452565	1.43092834643601e-14	-0.933864860780951	8.53885783888989e-13	MirTarget	-0.148435082691444	3.12923991420214e-09		NA	NA	NA
hsa-miR-34a-5p	CNTN2	1.9016323452565	1.43092834643601e-14	-3.83211666052187	2.86131751350646e-14	MirTarget;miRNATAP	-0.541916829647253	2.97659039331274e-08		NA	NA	NA
hsa-miR-34a-5p	CNTNAP1	1.9016323452565	1.43092834643601e-14	-1.46743494896109	1.9231693722072e-07	MirTarget;miRNATAP	-0.361612589518465	1.05688714782598e-11		NA	NA	NA
hsa-miR-34a-5p	CNTNAP2	1.9016323452565	1.43092834643601e-14	-1.31474968490572	0.115046978601333	miRNATAP	-0.669498950447693	2.24310469946169e-05		NA	NA	NA
hsa-miR-34a-5p	COL12A1	1.9016323452565	1.43092834643601e-14	0.611588153376471	0.134337648747937	MirTarget;miRNATAP	-0.279272089437204	0.00031460547783989		NA	NA	NA
hsa-miR-34a-5p	COL5A2	1.9016323452565	1.43092834643601e-14	0.192620068784939	0.640929497139689	MirTarget	-0.411001400817508	1.17355783845956e-07		NA	NA	NA
hsa-miR-34a-5p	CORO1C	1.9016323452565	1.43092834643601e-14	-1.12142787999647	2.05016310243217e-07	MirTarget;miRNATAP	-0.392545975185811	2.7908848641711e-23		NA	NA	NA
hsa-miR-34a-5p	CPEB2	1.9016323452565	1.43092834643601e-14	-1.81286293242937	3.69342740660752e-14	miRNATAP	-0.291011235456475	2.84988574218449e-10		NA	NA	NA
hsa-miR-34a-5p	CPEB3	1.9016323452565	1.43092834643601e-14	-1.29730351097465	1.42439515101264e-11	miRNATAP	-0.148597569036113	6.61814157178919e-05		NA	NA	NA
hsa-miR-34a-5p	CR2	1.9016323452565	1.43092834643601e-14	-1.531216649811	0.0724964985086472	MirTarget	-0.786896680830366	1.00551297999258e-06		NA	NA	NA
hsa-miR-34a-5p	CREB5	1.9016323452565	1.43092834643601e-14	-2.27679484644664	4.56595042875634e-09	miRNATAP	-0.504143048020364	7.47790714935664e-12		NA	NA	NA
hsa-miR-34a-5p	CRY2	1.9016323452565	1.43092834643601e-14	-1.68350116294318	3.19934219920631e-30	MirTarget	-0.170427547249712	9.16183249254523e-09		NA	NA	NA
hsa-miR-34a-5p	CSF1R	1.9016323452565	1.43092834643601e-14	-1.04722118455631	0.017969966085107	MirTarget;miRNATAP	-0.461603981922354	2.97565476458688e-08		NA	NA	NA
hsa-miR-34a-5p	CTCFL	1.9016323452565	1.43092834643601e-14	0.387073671890494	0.137748809597237	MirTarget	-0.12713116154714	0.0104269787056097		NA	NA	NA
hsa-miR-34a-5p	CTDSP2	1.9016323452565	1.43092834643601e-14	-0.394176502610892	0.00968619889118797	miRNATAP	-0.220129999724653	4.60947226678767e-15		NA	NA	NA
hsa-miR-34a-5p	CXCL9	1.9016323452565	1.43092834643601e-14	1.49927890864915	0.0365261889675859	miRNAWalker2_validate	-0.477505485788987	0.000460935899317861		NA	NA	NA
hsa-miR-34a-5p	CYTH3	1.9016323452565	1.43092834643601e-14	-0.272207622459217	0.193434635786576	mirMAP	-0.298341379420807	1.04053009788257e-14		NA	NA	NA
hsa-miR-34a-5p	DAAM1	1.9016323452565	1.43092834643601e-14	-0.942213696830475	0.00027775597362759	MirTarget;miRNATAP	-0.314744989230111	9.66343935466443e-11		NA	NA	NA
hsa-miR-34a-5p	DDAH2	1.9016323452565	1.43092834643601e-14	-0.590477754227921	0.0158687108919737	miRNAWalker2_validate	-0.150401571550365	0.00124243345827397		NA	NA	NA
hsa-miR-34a-5p	DDX21	1.9016323452565	1.43092834643601e-14	-0.174859915697837	0.500915985498721	miRNAWalker2_validate	-0.178783649545985	0.000279363298038951		NA	NA	NA
hsa-miR-34a-5p	DDX24	1.9016323452565	1.43092834643601e-14	-0.701530380473533	7.79136794467797e-09	miRNAWalker2_validate	-0.179493917005899	2.56802184701683e-15		NA	NA	NA
hsa-miR-34a-5p	DEGS1	1.9016323452565	1.43092834643601e-14	-0.464688481546998	0.0932815628732545	miRNAWalker2_validate	-0.34245508039683	3.13311024092033e-11		NA	NA	NA
hsa-miR-34a-5p	DIRAS1	1.9016323452565	1.43092834643601e-14	-3.18575368653498	5.11429118270038e-08	mirMAP	-0.654174247818005	4.28381101103868e-09		NA	NA	NA
hsa-miR-34a-5p	DIXDC1	1.9016323452565	1.43092834643601e-14	-3.01066558370526	1.36952954348107e-19	MirTarget	-0.723463516687314	5.53009644256615e-32		NA	NA	NA
hsa-miR-34a-5p	DLL1	1.9016323452565	1.43092834643601e-14	-0.904670506944925	0.0103219273832339	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.163044794044794	0.0155179086068895	22438124	Delta tocotrienol suppresses Notch 1 pathway by upregulating miR 34a in nonsmall cell lung cancer cells		lung squamous cell cancer
hsa-miR-34a-5p	DPYSL4	1.9016323452565	1.43092834643601e-14	-1.62416184385166	0.0138700586678457	miRNATAP	-0.404329081013691	0.00130520806060972		NA	NA	NA
hsa-miR-34a-5p	DUSP8	1.9016323452565	1.43092834643601e-14	-2.17002902781112	4.33786956113647e-11	MirTarget	-0.349194381507623	3.49403240680451e-08		NA	NA	NA
hsa-miR-34a-5p	EMP1	1.9016323452565	1.43092834643601e-14	-2.56201861439692	2.636649671729e-13	miRNAWalker2_validate	-0.262080004827708	0.000128173715780061		NA	NA	NA
hsa-miR-34a-5p	EPB41L2	1.9016323452565	1.43092834643601e-14	-1.52525304500616	1.08185687005731e-08	miRNAWalker2_validate	-0.419310580386464	3.6963933562603e-17		NA	NA	NA
hsa-miR-34a-5p	ERC1	1.9016323452565	1.43092834643601e-14	-1.0981015647741	3.01720605629387e-09	mirMAP;miRNATAP	-0.350825679987726	3.55360868118575e-25		NA	NA	NA
hsa-miR-34a-5p	ESYT2	1.9016323452565	1.43092834643601e-14	-0.746139987963661	9.56205989329786e-07	miRNAWalker2_validate	-0.151148519995629	1.73556812772753e-07		NA	NA	NA
hsa-miR-34a-5p	EVC	1.9016323452565	1.43092834643601e-14	-1.68202719143955	3.16757001123632e-05	mirMAP	-0.41704137787758	5.2678666002636e-08		NA	NA	NA
hsa-miR-34a-5p	F2RL2	1.9016323452565	1.43092834643601e-14	-0.074170778593706	0.882857232515843	MirTarget;miRNATAP	-0.364915734765217	0.000128912113283974		NA	NA	NA
hsa-miR-34a-5p	FAIM2	1.9016323452565	1.43092834643601e-14	-5.19306317048563	1.8116701555082e-19	mirMAP	-0.83047667568324	9.76727475500724e-14		NA	NA	NA
hsa-miR-34a-5p	FAM131B	1.9016323452565	1.43092834643601e-14	-1.33611947709599	0.000824414564419036	MirTarget	-0.456748498365561	1.21255636147528e-09		NA	NA	NA
hsa-miR-34a-5p	FAM168A	1.9016323452565	1.43092834643601e-14	-0.715878355157019	0.0048087062534339	mirMAP	-0.360026152917752	1.92370403342131e-14		NA	NA	NA
hsa-miR-34a-5p	FAM46A	1.9016323452565	1.43092834643601e-14	-1.53838927503324	2.52497889501001e-11	miRNAWalker2_validate;miRNATAP	-0.148703953998686	0.000915283294094036		NA	NA	NA
hsa-miR-34a-5p	FAM78A	1.9016323452565	1.43092834643601e-14	-0.17566660865732	0.571673572062009	mirMAP	-0.163128244620608	0.00572066900207895		NA	NA	NA
hsa-miR-34a-5p	FAT3	1.9016323452565	1.43092834643601e-14	-2.79096679677476	3.40343867448209e-06	miRNATAP	-0.238159689235018	0.0399842431144992		NA	NA	NA
hsa-miR-34a-5p	FAT4	1.9016323452565	1.43092834643601e-14	-2.56665423966553	1.33682061275506e-12	MirTarget	-0.550641148269351	9.44525623155378e-16		NA	NA	NA
hsa-miR-34a-5p	FGD6	1.9016323452565	1.43092834643601e-14	0.159851453122091	0.537015582004778	MirTarget;miRNATAP	-0.277924902556364	9.82127532053168e-09		NA	NA	NA
hsa-miR-34a-5p	FIGN	1.9016323452565	1.43092834643601e-14	-0.337235559801681	0.468810304921439	miRNAWalker2_validate	-0.281475875337614	0.00145298251694832		NA	NA	NA
hsa-miR-34a-5p	FMNL2	1.9016323452565	1.43092834643601e-14	-0.529083916997439	0.0893498623305676	miRNATAP	-0.463303191057109	6.30936473695651e-16	26103003	MicroRNA 34a targets FMNL2 and E2F5 and suppresses the progression of colorectal cancer; FMNL2 and E2F5 were identified as direct targets of miR-34a; Reintroduction of FMNL2 or E2F5 without 3'UTR region reversed the inhibitory effects of miR-34a on cell proliferation and invasion; MiR-34a was down-regulated in CRC cells and inversely correlated with FMNL2 and E2F5 expressions; Our study suggests that miR-34a is an important tumor suppressor of CRC progression by targeting FMNL2 and E2F5 thus providing new insight into the molecular mechanisms underlying CRC progression and establishing a strong potential for the application of miR-34a as a novel therapeutic marker against CRC	progression	colorectal cancer
hsa-miR-34a-5p	FOXJ2	1.9016323452565	1.43092834643601e-14	-0.61900156905543	0.000173363046232332	MirTarget;miRNATAP	-0.166339600987044	9.1041064614196e-08		NA	NA	NA
hsa-miR-34a-5p	FOXK1	1.9016323452565	1.43092834643601e-14	-0.292133622173698	0.132125670821422	mirMAP	-0.133228968661877	0.000287915852148464		NA	NA	NA
hsa-miR-34a-5p	FOXN2	1.9016323452565	1.43092834643601e-14	-0.201449704983224	0.266609612236866	miRNATAP	-0.113970816965055	0.000908187641903563		NA	NA	NA
hsa-miR-34a-5p	FOXN3	1.9016323452565	1.43092834643601e-14	-1.43525991184281	2.70084540955391e-16	miRNATAP	-0.289797930927111	2.75546105297621e-18		NA	NA	NA
hsa-miR-34a-5p	FUT8	1.9016323452565	1.43092834643601e-14	-0.00759422508200558	0.971820058391575	miRNATAP	-0.103025346753863	0.0116497865889195	27533464	Furthermore using microRNA array we identified FUT8 as one of the miR-26a miR-34a and miR-146a-targeted genes		liver cancer
hsa-miR-34a-5p	GAB1	1.9016323452565	1.43092834643601e-14	-0.893753640154927	1.35889350853124e-06	MirTarget	-0.188182529050272	8.58822853873461e-08		NA	NA	NA
hsa-miR-34a-5p	GAS1	1.9016323452565	1.43092834643601e-14	-2.1882386842391	0.000375177981793486	miRNAWalker2_validate;miRNATAP	-0.926566103710993	4.11296403810168e-16	24220341	MiR 34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K/Akt/Bad pathway; Both miR-34a and GAS1 are frequently down-regulated in various tumors; However it has been reported that while GAS1 is down-regulated in papillary thyroid carcinoma PTC miR-34a is up-regulated in this specific type of cancer although their potential roles in PTC tumorigenesis have not been examined to date; A computational search revealed that miR-34a putatively binds to the 3'-UTR of GAS1 gene; In the present study we confirmed previous findings that miR-34a is up-regulated and GAS1 down-regulated in PTC tissues; Further studies indicated that GAS1 is directly targeted by miR-34a; Silencing of GAS1 had similar growth-promoting effects as overexpression of miR-34a; Taken together our results demonstrate that miR-34a regulates GAS1 expression to promote proliferation and suppress apoptosis in PTC cells via PI3K/Akt/Bad pathway	tumorigenesis	thyroid cancer
hsa-miR-34a-5p	GBP5	1.9016323452565	1.43092834643601e-14	0.912417033493665	0.155449791355904	MirTarget	-0.382499169463647	0.0017369345763329		NA	NA	NA
hsa-miR-34a-5p	GDPD5	1.9016323452565	1.43092834643601e-14	-0.630310111922114	0.0293909740910197	mirMAP	-0.213268425366357	0.000102263075725957		NA	NA	NA
hsa-miR-34a-5p	GEMIN5	1.9016323452565	1.43092834643601e-14	-0.199708326167447	0.120238384750959	miRNAWalker2_validate	-0.118367196443607	9.17420434212037e-07		NA	NA	NA
hsa-miR-34a-5p	GFRA1	1.9016323452565	1.43092834643601e-14	-4.99535302188274	6.14065741522982e-16	miRNATAP	-0.468603795786328	0.000115075184080931		NA	NA	NA
hsa-miR-34a-5p	GLCE	1.9016323452565	1.43092834643601e-14	0.259402696052151	0.172049271225319	MirTarget;miRNATAP	-0.103424672425006	0.00413607836566836		NA	NA	NA
hsa-miR-34a-5p	GLIS2	1.9016323452565	1.43092834643601e-14	-0.610818722003668	0.0527901481345749	MirTarget	-0.40401113067284	5.8023012566225e-12		NA	NA	NA
hsa-miR-34a-5p	GNAO1	1.9016323452565	1.43092834643601e-14	-3.60402838064813	1.60858876204295e-14	mirMAP	-0.912829449298286	9.94616074995399e-26		NA	NA	NA
hsa-miR-34a-5p	GPC6	1.9016323452565	1.43092834643601e-14	-2.70666453497929	7.48358520640858e-07	MirTarget	-0.7555559007653	1.85995303111966e-13		NA	NA	NA
hsa-miR-34a-5p	GPR156	1.9016323452565	1.43092834643601e-14	-1.25653479411111	0.0136152326151988	MirTarget	-0.83298074486789	3.88570187308379e-19		NA	NA	NA
hsa-miR-34a-5p	GREM2	1.9016323452565	1.43092834643601e-14	-4.9852150121131	1.5808751237327e-14	MirTarget;miRNATAP	-0.444714182367586	0.00048212236936567		NA	NA	NA
hsa-miR-34a-5p	GRID1	1.9016323452565	1.43092834643601e-14	-0.61772636758298	0.168665600534068	miRNATAP	-0.177009786008275	0.0386174462416638		NA	NA	NA
hsa-miR-34a-5p	GYG1	1.9016323452565	1.43092834643601e-14	-0.707345868023464	1.26958679121177e-07	miRNAWalker2_validate	-0.136487387233102	8.11420430054654e-08		NA	NA	NA
hsa-miR-34a-5p	HAPLN4	1.9016323452565	1.43092834643601e-14	0.126147088785814	0.776209220485584	mirMAP	-0.206852231928114	0.014314520193702		NA	NA	NA
hsa-miR-34a-5p	HIPK2	1.9016323452565	1.43092834643601e-14	-0.569766486297519	0.0176403507362252	mirMAP	-0.219334183339887	1.30387235923701e-06		NA	NA	NA
hsa-miR-34a-5p	HMGA2	1.9016323452565	1.43092834643601e-14	3.20669547753427	0.000374823650222635	miRNAWalker2_validate	-0.570917515229347	0.000926842607230156	18803879	miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making	poor survival;differentiation	gastric cancer
hsa-miR-34a-5p	HPSE	1.9016323452565	1.43092834643601e-14	0.666621208462529	0.156142725087854	MirTarget	-0.422120081290521	1.9400254393159e-06		NA	NA	NA
hsa-miR-34a-5p	IGF2BP3	1.9016323452565	1.43092834643601e-14	2.6299525966699	0.000210097359173809	miRNAWalker2_validate	-0.356009987313672	0.00889898177532554		NA	NA	NA
hsa-miR-34a-5p	IGFBP5	1.9016323452565	1.43092834643601e-14	-2.81356106012445	2.49904604393601e-08	mirMAP	-0.664249410135242	3.4074345255981e-12		NA	NA	NA
hsa-miR-34a-5p	IL6R	1.9016323452565	1.43092834643601e-14	-1.86576803083567	2.67166891084766e-06	MirTarget	-0.286520476038065	0.000171312695111806		NA	NA	NA
hsa-miR-34a-5p	INHBB	1.9016323452565	1.43092834643601e-14	-1.63532338824153	1.3666012569742e-06	miRNATAP	-0.243244739481652	0.000182207922114652		NA	NA	NA
hsa-miR-34a-5p	ITPKB	1.9016323452565	1.43092834643601e-14	-1.70322432049595	4.43562078746451e-23	mirMAP	-0.248469992524147	1.46624879489722e-13		NA	NA	NA
hsa-miR-34a-5p	ITPR2	1.9016323452565	1.43092834643601e-14	-0.177554271932524	0.436106439712671	MirTarget	-0.204451958085315	1.90493212189564e-06		NA	NA	NA
hsa-miR-34a-5p	ITSN1	1.9016323452565	1.43092834643601e-14	-0.611059124760145	8.82737803628848e-05	mirMAP	-0.166162472068446	1.55411816510568e-08		NA	NA	NA
hsa-miR-34a-5p	JAKMIP1	1.9016323452565	1.43092834643601e-14	0.374468407061645	0.504232790948634	MirTarget;miRNATAP	-0.278669647531769	0.00900854053605573		NA	NA	NA
hsa-miR-34a-5p	JMJD1C	1.9016323452565	1.43092834643601e-14	-0.840910081913005	7.98664644216222e-07	miRNATAP	-0.157207821622443	1.28804548834048e-06		NA	NA	NA
hsa-miR-34a-5p	KCNAB2	1.9016323452565	1.43092834643601e-14	-0.720387769910192	0.0156755477759335	MirTarget;mirMAP	-0.311627519483046	2.73286475641682e-08		NA	NA	NA
hsa-miR-34a-5p	KCNK3	1.9016323452565	1.43092834643601e-14	-3.6338132446768	1.0612212729052e-10	MirTarget	-0.571573366414864	1.32401052672489e-07		NA	NA	NA
hsa-miR-34a-5p	KCNQ4	1.9016323452565	1.43092834643601e-14	-2.63982014948538	9.7947726847549e-09	mirMAP	-0.693583712977992	9.27954465587282e-16		NA	NA	NA
hsa-miR-34a-5p	KIAA1462	1.9016323452565	1.43092834643601e-14	-1.7207439664468	1.06773819784283e-07	MirTarget	-0.430496028061196	1.74494966464615e-12		NA	NA	NA
hsa-miR-34a-5p	KIAA1644	1.9016323452565	1.43092834643601e-14	-4.40439862301283	1.42085780669109e-16	MirTarget	-0.985302403515769	7.6388906367849e-23		NA	NA	NA
hsa-miR-34a-5p	KIF2A	1.9016323452565	1.43092834643601e-14	-0.215409671865721	0.231461115751439	miRNAWalker2_validate	-0.169504620039035	5.40570822486798e-07		NA	NA	NA
hsa-miR-34a-5p	KIF5B	1.9016323452565	1.43092834643601e-14	-0.636463278164481	1.60031466459174e-06	miRNAWalker2_validate	-0.121805938075758	1.35627819704988e-06		NA	NA	NA
hsa-miR-34a-5p	KIT	1.9016323452565	1.43092834643601e-14	-2.52159771280238	8.03290749995369e-07	MirTarget	-0.312332886384761	0.00150658023755356		NA	NA	NA
hsa-miR-34a-5p	KITLG	1.9016323452565	1.43092834643601e-14	-1.58421888595384	1.26958469493711e-05	MirTarget	-0.471477676973797	4.5117297895647e-12		NA	NA	NA
hsa-miR-34a-5p	KLC1	1.9016323452565	1.43092834643601e-14	-0.608227882601959	2.78949652074599e-07	miRNAWalker2_validate	-0.120553713572346	7.85293803286174e-08		NA	NA	NA
hsa-miR-34a-5p	KLF13	1.9016323452565	1.43092834643601e-14	-1.16141618366409	1.36372480238947e-05	mirMAP	-0.347302984351715	4.10397341226692e-12		NA	NA	NA
hsa-miR-34a-5p	KLF4	1.9016323452565	1.43092834643601e-14	-2.66899133268835	3.11667300306613e-16	MirTarget;miRNATAP	-0.147421843483855	0.0225947171913702		NA	NA	NA
hsa-miR-34a-5p	KLF7	1.9016323452565	1.43092834643601e-14	-0.396294178926278	0.170315776862033	miRNATAP	-0.378490603262785	1.69793480441075e-12		NA	NA	NA
hsa-miR-34a-5p	KY	1.9016323452565	1.43092834643601e-14	-3.92273615985382	4.39505790976942e-15	MirTarget	-0.784704461120385	1.63081634698696e-16		NA	NA	NA
hsa-miR-34a-5p	LDHA	1.9016323452565	1.43092834643601e-14	0.407908079011101	0.0898840708480306	miRNAWalker2_validate;MirTarget;miRNATAP	-0.192159149787817	2.38615615832768e-05	26902416;25333573;27186405	The miR 34a LDHA axis regulates glucose metabolism and tumor growth in breast cancer; We also performed luciferase reporter assays and found that LDHA was a direct target of miR-34a; Repression of LDHA by miR-34a suppressed glycolysis and cell proliferation in breast cancer cells in vitro; Our findings provide clues regarding the role of miR-34a as a tumor suppressor in breast cancer through the inhibition of LDHA both in vitro and in vivo; Targeting LDHA through miR-34a could be a potential therapeutic strategy in breast cancer;Inhibition of lactate dehydrogenase A by microRNA 34a resensitizes colon cancer cells to 5 fluorouracil; Furthermore LDHA was shown to be a direct target of miR-34a; Overexpression of miR-34a reduced the expression of LDHA probably through binding to the 3' untranslated region leading to the re-sensitization of 5-FU-resistant cancer cells to 5-FU; In conclusion the current study showed that miR-34a is involved in sensitivity to 5-FU in part through its effects on LDHA expression;HPV E6/p53 mediated down regulation of miR 34a inhibits Warburg effect through targeting LDHA in cervical cancer; Subsequently lactate dehydrogenase A LDHA which catalyzes the last key step in glycolysis was identified as a direct target of miR-34a; Silencing of LDHA or introduction of miR-34a significantly attenuated colony formation ability and invasive capacity of SiHa and HeLa cells and these effects were fully compromised by reintroduction of LDHA	;;	breast cancer;colon cancer;cervical and endocervical cancer
hsa-miR-34a-5p	LHX2	1.9016323452565	1.43092834643601e-14	2.06856057446591	0.000890579247157729	miRNATAP	-0.263219666179235	0.0274145216141966		NA	NA	NA
hsa-miR-34a-5p	LOXL3	1.9016323452565	1.43092834643601e-14	-0.968455677583596	0.000809448004647299	MirTarget;miRNATAP	-0.400597917013039	9.32832039663351e-14		NA	NA	NA
hsa-miR-34a-5p	LRCH1	1.9016323452565	1.43092834643601e-14	-1.09367192084794	2.38111166969073e-11	MirTarget	-0.240044825488938	7.82870694753625e-15		NA	NA	NA
hsa-miR-34a-5p	LRRC40	1.9016323452565	1.43092834643601e-14	-0.0455784335637732	0.755138358864283	miRNAWalker2_validate;MirTarget	-0.106025955765025	0.000119907432013954		NA	NA	NA
hsa-miR-34a-5p	LRRC7	1.9016323452565	1.43092834643601e-14	-3.91787209255121	5.73746646820421e-15	MirTarget	-0.578343713139293	2.7252019018456e-09		NA	NA	NA
hsa-miR-34a-5p	MAP1A	1.9016323452565	1.43092834643601e-14	-2.81936532211288	1.95093328905874e-14	MirTarget;miRNATAP	-0.631471488247341	8.54216775732896e-20		NA	NA	NA
hsa-miR-34a-5p	MAP1B	1.9016323452565	1.43092834643601e-14	-3.18358434812783	4.83606017602339e-16	miRNAWalker2_validate	-0.786803751441067	2.86731642139992e-27		NA	NA	NA
hsa-miR-34a-5p	MAP3K14	1.9016323452565	1.43092834643601e-14	-0.929542138683687	1.31735308419243e-05	MirTarget	-0.168509021928338	3.5079349902853e-05		NA	NA	NA
hsa-miR-34a-5p	MAP4	1.9016323452565	1.43092834643601e-14	-0.677894471246955	4.08007924790953e-07	miRNAWalker2_validate	-0.147266445783703	6.04997841521672e-09		NA	NA	NA
hsa-miR-34a-5p	MAP4K4	1.9016323452565	1.43092834643601e-14	0.130872521838526	0.522814141079271	MirTarget	-0.259802212401119	8.07915118814483e-12		NA	NA	NA
hsa-miR-34a-5p	MAPK1	1.9016323452565	1.43092834643601e-14	-0.300413846088826	0.0202503240217449	mirMAP	-0.113934200811126	2.89029232507908e-06		NA	NA	NA
hsa-miR-34a-5p	MAPT	1.9016323452565	1.43092834643601e-14	-2.57854469569689	1.03709852332835e-08	MirTarget;miRNATAP	-0.387660765401499	7.71091072422528e-06		NA	NA	NA
hsa-miR-34a-5p	MCFD2	1.9016323452565	1.43092834643601e-14	-0.273710952309139	0.0802130111446696	miRNATAP	-0.192772321331484	3.36229390696629e-11		NA	NA	NA
hsa-miR-34a-5p	MCTP1	1.9016323452565	1.43092834643601e-14	-0.930962901937398	0.0391633392445751	miRNATAP	-0.475205056199198	2.12844533170181e-08		NA	NA	NA
hsa-miR-34a-5p	MDGA1	1.9016323452565	1.43092834643601e-14	-1.00154386684221	0.0303398006837731	mirMAP	-0.549905797426372	2.04266806479283e-10		NA	NA	NA
hsa-miR-34a-5p	ME1	1.9016323452565	1.43092834643601e-14	-1.33126432667221	0.000244521518404576	miRNAWalker2_validate	-0.518143353901709	1.60766756065236e-14		NA	NA	NA
hsa-miR-34a-5p	MGAT5B	1.9016323452565	1.43092834643601e-14	-0.359608389802055	0.458048727881491	MirTarget;miRNATAP	-0.222488785718032	0.0158950552804138		NA	NA	NA
hsa-miR-34a-5p	MLLT3	1.9016323452565	1.43092834643601e-14	-0.649777649033278	0.0222203114424632	MirTarget;miRNATAP	-0.187377477462236	0.000522685788785214		NA	NA	NA
hsa-miR-34a-5p	MPP2	1.9016323452565	1.43092834643601e-14	-1.4560422878474	0.000139696972689277	MirTarget;miRNATAP	-0.330788230229271	5.4137231125192e-06		NA	NA	NA
hsa-miR-34a-5p	MTMR2	1.9016323452565	1.43092834643601e-14	-0.0692560870120555	0.555584242644447	miRNAWalker2_validate	-0.1002204236336	5.42625596882733e-06		NA	NA	NA
hsa-miR-34a-5p	MTMR9	1.9016323452565	1.43092834643601e-14	-0.836073789582016	3.17094975834284e-09	miRNAWalker2_validate	-0.139182461106227	2.50493901668674e-07		NA	NA	NA
hsa-miR-34a-5p	MYADM	1.9016323452565	1.43092834643601e-14	-2.82656540386901	8.49316181730987e-14	MirTarget	-0.48421438979298	2.90524776288772e-11		NA	NA	NA
hsa-miR-34a-5p	MYC	1.9016323452565	1.43092834643601e-14	-1.76968865889126	2.71829937908146e-06	miRNAWalker2_validate;miRTarBase	-0.359767953473847	5.62932761832786e-07	25572695;25686834;21460242;22159222;23640973;22830357;22235332	The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE;miR 34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c Myc pathway;Myc mediated repression of microRNA 34a promotes high grade transformation of B cell lymphoma by dysregulation of FoxP1;MicroRNA 34a suppresses malignant transformation by targeting c Myc transcriptional complexes in human renal cell carcinoma; We investigated the functional effects of microRNA-34a miR-34a on c-Myc transcriptional complexes in renal cell carcinoma; miR-34a down-regulated expression of multiple oncogenes including c-Myc by targeting its 3' untranslated region which was revealed by luciferase reporter assays; Our results demonstrate that miR-34a suppresses assembly and function of the c-Myc complex that activates or elongates transcription indicating a novel role of miR-34a in the regulation of transcription by c-Myc;Among them miR-34a was also associated with poor prognosis in 2 independent series of leukemic and nodal MCL and in cooperation with high expression of the MYC oncogene;We report that miR-34a did not inhibit cell proliferation notwithstanding a marked down-regulation of c-MYC;MicroRNA 34a modulates c Myc transcriptional complexes to suppress malignancy in human prostate cancer cells; We studied the functional effects of miR-34a on c-Myc transcriptional complexes in PC-3 prostate cancer cells; miR-34a downregulated expression of c-Myc oncogene by targeting its 3' UTR as shown by luciferase reporter assays; This is the first report to document that miR-34a suppresses assembly and function of the c-Myc-Skp2-Miz1 complex that activates RhoA and the c-Myc-pTEFB complex that elongates transcription of various genes suggesting a novel role of miR-34a in the regulation of transcription by c-Myc complex	;;;malignant trasformation;worse prognosis;;	bladder cancer;liver cancer;B cell lymphoma;kidney renal cell cancer;lymphoma;lymphoma;prostate cancer
hsa-miR-34a-5p	NAV1	1.9016323452565	1.43092834643601e-14	-0.418200324441875	0.108742163308665	MirTarget;miRNATAP	-0.317572593313379	6.3486197910259e-11		NA	NA	NA
hsa-miR-34a-5p	NAV3	1.9016323452565	1.43092834643601e-14	-3.21771083204903	7.35356644104861e-11	MirTarget	-0.717888709443055	1.55652183905208e-14		NA	NA	NA
hsa-miR-34a-5p	NCOR2	1.9016323452565	1.43092834643601e-14	-0.35204425841984	0.0178506335854312	MirTarget	-0.157919625529881	1.41350087236073e-08		NA	NA	NA
hsa-miR-34a-5p	NDST1	1.9016323452565	1.43092834643601e-14	-0.250883286824299	0.176743296307116	MirTarget;miRNATAP	-0.152337669911294	1.37515709369466e-05		NA	NA	NA
hsa-miR-34a-5p	NFAM1	1.9016323452565	1.43092834643601e-14	-0.407436496682177	0.299538525694089	MirTarget	-0.274202481638733	0.000230184082966138		NA	NA	NA
hsa-miR-34a-5p	NFASC	1.9016323452565	1.43092834643601e-14	-2.95717922837883	4.31475260476481e-14	mirMAP	-0.586182373828648	3.80269106863198e-15	22292433	Transcriptional activation of microRNA 34a by NF kappa B in human esophageal cancer cells		esophageal cancer
hsa-miR-34a-5p	NFE2L1	1.9016323452565	1.43092834643601e-14	-0.171483758009488	0.176829520001656	MirTarget;miRNATAP	-0.125397282103513	1.30424037317666e-07		NA	NA	NA
hsa-miR-34a-5p	NFIC	1.9016323452565	1.43092834643601e-14	-1.57099939804843	8.09399770340134e-09	mirMAP	-0.433163394592829	1.52890240175384e-17		NA	NA	NA
hsa-miR-34a-5p	NGFR	1.9016323452565	1.43092834643601e-14	-2.71562668756498	2.85979409356053e-06	mirMAP	-0.651447322603427	3.13859594639451e-09		NA	NA	NA
hsa-miR-34a-5p	NNT	1.9016323452565	1.43092834643601e-14	-0.403871740015822	0.0362553547619169	miRNAWalker2_validate	-0.155593680180507	1.97939514593657e-05		NA	NA	NA
hsa-miR-34a-5p	NOTCH2	1.9016323452565	1.43092834643601e-14	-0.649665466220466	0.00179668614494204	miRNAWalker2_validate;miRNATAP	-0.276940453993645	8.61027725147104e-13		NA	NA	NA
hsa-miR-34a-5p	NPTX1	1.9016323452565	1.43092834643601e-14	-3.0548528465665	5.58655593069716e-09	miRNATAP	-0.485830851335166	1.41314121745096e-06		NA	NA	NA
hsa-miR-34a-5p	NSD1	1.9016323452565	1.43092834643601e-14	-0.140278049651839	0.313165028415798	miRNATAP	-0.115584242688162	9.97030291056323e-06		NA	NA	NA
hsa-miR-34a-5p	NT5E	1.9016323452565	1.43092834643601e-14	-1.32095136217544	0.00557630949266939	miRNAWalker2_validate	-0.409646516674786	5.76417595066467e-06		NA	NA	NA
hsa-miR-34a-5p	NTN1	1.9016323452565	1.43092834643601e-14	-2.90496349995287	8.65251378142323e-09	mirMAP	-0.605001166287899	2.97419227887426e-10		NA	NA	NA
hsa-miR-34a-5p	NUCKS1	1.9016323452565	1.43092834643601e-14	-0.202495776728364	0.103316884003021	miRNAWalker2_validate	-0.129237291176526	2.61972308129445e-08		NA	NA	NA
hsa-miR-34a-5p	NUMBL	1.9016323452565	1.43092834643601e-14	-0.572631697203964	0.00314600902770347	MirTarget;miRNATAP	-0.230953869887576	1.93509438115372e-10		NA	NA	NA
hsa-miR-34a-5p	OLFML1	1.9016323452565	1.43092834643601e-14	-2.63819844236782	1.29082006394553e-13	MirTarget	-0.39744456650176	7.82931261640244e-09		NA	NA	NA
hsa-miR-34a-5p	P2RY14	1.9016323452565	1.43092834643601e-14	-3.10430945553395	4.16925369709357e-16	MirTarget	-0.507122556048104	5.81652122511074e-12		NA	NA	NA
hsa-miR-34a-5p	PAFAH1B2	1.9016323452565	1.43092834643601e-14	-0.0796507734002518	0.73025873683242	miRNATAP	-0.163073868660292	0.00019070504272219		NA	NA	NA
hsa-miR-34a-5p	PAX5	1.9016323452565	1.43092834643601e-14	-1.22891527233864	0.0475460185287537	mirMAP	-0.520882375191672	9.09442565723312e-06		NA	NA	NA
hsa-miR-34a-5p	PDE4B	1.9016323452565	1.43092834643601e-14	-2.61427639301444	2.71471237993639e-11	MirTarget	-0.506999362009682	1.27276496619996e-11		NA	NA	NA
hsa-miR-34a-5p	PDGFRA	1.9016323452565	1.43092834643601e-14	-2.37640583073564	1.39737819859365e-09	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.295453243484317	9.87541559838975e-05	22750848	Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network		glioblastoma
hsa-miR-34a-5p	PDGFRB	1.9016323452565	1.43092834643601e-14	-1.03522303801072	0.00301738788961229	MirTarget	-0.3682858109356	2.13745951637981e-08	24837198	MicroRNA 34A inhibits the growth invasion and metastasis of gastric cancer by targeting PDGFR and MET expression; In this study our aim was to identify the miRNAs that target PDGFR-α/β and to study the functions of these miRNAs miR-34a was predicted to target PDGFR and luciferase reporter assays showed that miR-34a could directly target PDGFR; Moreover the cancer-associated cell signalling pathway was studied and we found that miR-34a could inhibit Akt PKB protein kinase B phosphorylation which was restored by the overexpression of both PDGFR and MET; In conclusion miR-34a may act as a potential tumour suppressor in gastric cancer and is associated with the mechanisms of gastric cancer metastasis; miR-34a can inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K phosphoinositide 3-kinase/Akt pathway	metastasis	gastric cancer
hsa-miR-34a-5p	PDZRN3	1.9016323452565	1.43092834643601e-14	-3.50096884424761	2.32611531570638e-14	miRNATAP	-0.741471723987459	1.396145566992e-17		NA	NA	NA
hsa-miR-34a-5p	PEA15	1.9016323452565	1.43092834643601e-14	-0.194185815009944	0.222952788863459	miRNAWalker2_validate;MirTarget;miRNATAP	-0.102703644814614	0.000659711857432581		NA	NA	NA
hsa-miR-34a-5p	PEG10	1.9016323452565	1.43092834643601e-14	-1.94098497488928	0.00571305721030311	miRNATAP	-0.70498740438012	1.04174293750708e-07		NA	NA	NA
hsa-miR-34a-5p	PFKM	1.9016323452565	1.43092834643601e-14	-0.840384359428003	7.29274116373987e-06	MirTarget	-0.1639877216747	4.3308316592925e-06		NA	NA	NA
hsa-miR-34a-5p	PGM1	1.9016323452565	1.43092834643601e-14	-0.551661007062109	0.0288946564086057	MirTarget;miRNATAP	-0.289415216528427	9.09283245090733e-10		NA	NA	NA
hsa-miR-34a-5p	PHF19	1.9016323452565	1.43092834643601e-14	-0.569884194868888	0.0249085385065336	miRNAWalker2_validate;miRNATAP	-0.366294350697072	5.86362106799447e-15		NA	NA	NA
hsa-miR-34a-5p	PHYHIP	1.9016323452565	1.43092834643601e-14	-3.99834802867978	1.29887445710253e-14	mirMAP	-0.609534862577939	1.26961483915618e-09		NA	NA	NA
hsa-miR-34a-5p	PID1	1.9016323452565	1.43092834643601e-14	-3.77845389090464	1.61614679973113e-19	miRNATAP	-0.512529729993115	3.74953552570536e-10		NA	NA	NA
hsa-miR-34a-5p	PLCB1	1.9016323452565	1.43092834643601e-14	-1.22654831568585	1.86169905806194e-05	miRNATAP	-0.120203100488648	0.0292103601487345		NA	NA	NA
hsa-miR-34a-5p	PLEKHM3	1.9016323452565	1.43092834643601e-14	-0.67250523933801	7.96919433369335e-05	MirTarget	-0.138835306502652	1.84380277662518e-05		NA	NA	NA
hsa-miR-34a-5p	PLN	1.9016323452565	1.43092834643601e-14	-4.76371410369812	1.48137764300282e-11	MirTarget	-1.19789670412661	1.11338611922565e-19		NA	NA	NA
hsa-miR-34a-5p	PLXNA4	1.9016323452565	1.43092834643601e-14	-2.25456361904941	4.96438419774251e-05	mirMAP	-0.687748520191177	4.62013158979983e-11		NA	NA	NA
hsa-miR-34a-5p	POLR1A	1.9016323452565	1.43092834643601e-14	0.288169928524328	0.0751341579451263	mirMAP	-0.1211875232629	7.50680130973204e-05		NA	NA	NA
hsa-miR-34a-5p	POU6F1	1.9016323452565	1.43092834643601e-14	-1.5750422312555	5.44817028015342e-10	MirTarget	-0.326117158355093	1.35185511504135e-11		NA	NA	NA
hsa-miR-34a-5p	PPAN-P2RY11	1.9016323452565	1.43092834643601e-14	-3.29277646334275	0.000143460292404528	mirMAP	-0.472624522786711	0.00442735444460448		NA	NA	NA
hsa-miR-34a-5p	PPP1R16B	1.9016323452565	1.43092834643601e-14	-1.51043585925807	2.23466511532997e-06	MirTarget;miRNATAP	-0.254825654355549	3.06024841308157e-05		NA	NA	NA
hsa-miR-34a-5p	PPP2R3A	1.9016323452565	1.43092834643601e-14	-0.635587926025165	0.0133804555089022	MirTarget;miRNATAP	-0.336602423463064	1.88624747596278e-12		NA	NA	NA
hsa-miR-34a-5p	PPP2R5A	1.9016323452565	1.43092834643601e-14	-0.903448375131664	8.39328972558812e-12	MirTarget;miRNATAP	-0.101688531317395	7.12383430257492e-05		NA	NA	NA
hsa-miR-34a-5p	PRKAA2	1.9016323452565	1.43092834643601e-14	-3.1651157275578	4.06046613880045e-09	miRNATAP	-0.697992393841294	7.93258270698692e-12		NA	NA	NA
hsa-miR-34a-5p	PRKACB	1.9016323452565	1.43092834643601e-14	-1.11910356116881	7.24897707751757e-07	miRNATAP	-0.238915288481547	2.59419071561778e-08		NA	NA	NA
hsa-miR-34a-5p	PRKD1	1.9016323452565	1.43092834643601e-14	-1.53164811371414	4.119038025094e-05	miRNATAP	-0.269413114918258	0.000161989735484372	26895471	A novel miR 34a target protein kinase D1 stimulates cancer stemness and drug resistance through GSK3/β catenin signaling in breast cancer; Additionally we discovered that PRKD1 expression was negatively regulated by miR-34a binding to the PRKD1 3'-UTR; We also found that reduction of PRKD1 by ectopic miR-34a expression or PRKD1 siRNA treatment resulted in suppressed self-renewal ability in breast cancer stem cells; These results provide evidence that regulation of PRKD1 a novel miR-34a target contributes to overcoming cancer stemness and drug resistance in human breast cancer	drug resistance	breast cancer
hsa-miR-34a-5p	PRKG1	1.9016323452565	1.43092834643601e-14	-3.08984703833363	4.55204333556294e-10	miRNATAP	-0.920104832100479	6.91009801092045e-24		NA	NA	NA
hsa-miR-34a-5p	PROX1	1.9016323452565	1.43092834643601e-14	-2.49034953093375	1.14921276053561e-06	miRNATAP	-0.350714162316814	0.000365803849255272		NA	NA	NA
hsa-miR-34a-5p	PSKH1	1.9016323452565	1.43092834643601e-14	-0.324586105655697	0.0317241984209649	mirMAP	-0.114449084841355	6.16761512464708e-05		NA	NA	NA
hsa-miR-34a-5p	PTMS	1.9016323452565	1.43092834643601e-14	-0.205165066542105	0.389294656941897	miRNAWalker2_validate	-0.199647320290161	8.95375767520199e-06		NA	NA	NA
hsa-miR-34a-5p	PYGB	1.9016323452565	1.43092834643601e-14	-1.1864973505952	3.07666105152014e-08	miRNAWalker2_validate	-0.304052172852647	4.13963843774103e-14		NA	NA	NA
hsa-miR-34a-5p	RAB11FIP2	1.9016323452565	1.43092834643601e-14	-0.863768952812762	1.29857569721329e-05	MirTarget	-0.120248829639454	0.00153770620679209		NA	NA	NA
hsa-miR-34a-5p	RAP2A	1.9016323452565	1.43092834643601e-14	0.136362688904414	0.374073231500174	miRNAWalker2_validate	-0.187663735963077	4.39932624437351e-11		NA	NA	NA
hsa-miR-34a-5p	RARB	1.9016323452565	1.43092834643601e-14	-1.77858429602091	2.28807354868447e-06	miRNATAP	-0.37182010349897	2.11935735449156e-07		NA	NA	NA
hsa-miR-34a-5p	RASGRP4	1.9016323452565	1.43092834643601e-14	-1.81932059503105	2.30066832429026e-06	MirTarget	-0.421860932834008	7.68217450355339e-09		NA	NA	NA
hsa-miR-34a-5p	RASL12	1.9016323452565	1.43092834643601e-14	-3.19139275672019	6.99652952081998e-18	MirTarget	-0.632923398487444	2.6422348682003e-19		NA	NA	NA
hsa-miR-34a-5p	REEP3	1.9016323452565	1.43092834643601e-14	-0.227591837388122	0.197361726362941	miRNAWalker2_validate	-0.109316855396802	0.00108548189961392		NA	NA	NA
hsa-miR-34a-5p	RELN	1.9016323452565	1.43092834643601e-14	-4.70097153618157	2.41994737445055e-14	miRNATAP	-0.794629260378451	2.12226011368403e-11		NA	NA	NA
hsa-miR-34a-5p	RET	1.9016323452565	1.43092834643601e-14	-0.845706703693476	0.0349656102167993	MirTarget	-0.280340222615168	0.000232922767956132		NA	NA	NA
hsa-miR-34a-5p	RGP1	1.9016323452565	1.43092834643601e-14	-0.559845500700471	0.0212137137112516	mirMAP	-0.26723797785906	4.49661861767212e-09		NA	NA	NA
hsa-miR-34a-5p	RHOBTB3	1.9016323452565	1.43092834643601e-14	-0.711743990805872	0.0332323903973153	MirTarget	-0.148931351442163	0.0195413533468724		NA	NA	NA
hsa-miR-34a-5p	RIMS3	1.9016323452565	1.43092834643601e-14	-1.42027619315578	3.00440701262036e-05	MirTarget;miRNATAP	-0.440423795767199	5.22773176428325e-12		NA	NA	NA
hsa-miR-34a-5p	RIMS4	1.9016323452565	1.43092834643601e-14	-1.38584949700296	0.0181417434692426	miRNATAP	-0.244232012558525	0.0293470154550189		NA	NA	NA
hsa-miR-34a-5p	RNF216	1.9016323452565	1.43092834643601e-14	-0.284209271050796	0.0177325861546712	MirTarget;mirMAP	-0.146251468103723	5.05250661056923e-11		NA	NA	NA
hsa-miR-34a-5p	RORA	1.9016323452565	1.43092834643601e-14	-1.82057461685128	1.16708465709096e-09	miRNATAP	-0.301913889548582	1.45777777264069e-07		NA	NA	NA
hsa-miR-34a-5p	RPGRIP1L	1.9016323452565	1.43092834643601e-14	0.460572263954295	0.011911794887315	miRNATAP	-0.124872919765448	0.000328233396991803		NA	NA	NA
hsa-miR-34a-5p	RRAGC	1.9016323452565	1.43092834643601e-14	-0.343372136368613	0.147560743919937	MirTarget	-0.250143791429471	1.82647959978383e-08		NA	NA	NA
hsa-miR-34a-5p	RRAGD	1.9016323452565	1.43092834643601e-14	-1.28210533175691	5.97051882858326e-05	miRNATAP	-0.360340731127308	2.25475774104504e-09		NA	NA	NA
hsa-miR-34a-5p	RRAS	1.9016323452565	1.43092834643601e-14	-1.13229828735822	2.92783846173343e-05	miRNAWalker2_validate;MirTarget;miRNATAP	-0.265547196825665	2.42146653994062e-07		NA	NA	NA
hsa-miR-34a-5p	RSU1	1.9016323452565	1.43092834643601e-14	-0.521940994344366	0.000530310828940177	miRNAWalker2_validate	-0.165894570281477	4.53653029968444e-09		NA	NA	NA
hsa-miR-34a-5p	S1PR3	1.9016323452565	1.43092834643601e-14	-1.26632625143086	0.000598689169272835	MirTarget	-0.229301466797164	0.00114333101402024		NA	NA	NA
hsa-miR-34a-5p	SAA1	1.9016323452565	1.43092834643601e-14	0.580367147926712	0.500990586635041	miRNAWalker2_validate	-0.641422562877924	8.58051452440863e-05		NA	NA	NA
hsa-miR-34a-5p	SAMD14	1.9016323452565	1.43092834643601e-14	-0.753779143735079	0.0202276067098733	mirMAP	-0.313030855116708	3.16093593745217e-07		NA	NA	NA
hsa-miR-34a-5p	SATB1	1.9016323452565	1.43092834643601e-14	-1.41790516306492	3.44896934071801e-06	MirTarget;miRNATAP	-0.129358238042746	0.0280230512878416		NA	NA	NA
hsa-miR-34a-5p	SATB2	1.9016323452565	1.43092834643601e-14	0.10201173814094	0.745296023043312	miRNAWalker2_validate;MirTarget;miRNATAP	-0.117793414043594	0.0489086217297985		NA	NA	NA
hsa-miR-34a-5p	SCML2	1.9016323452565	1.43092834643601e-14	-0.950080740895381	0.0546941084335224	MirTarget;miRNATAP	-0.56046075684538	1.44678408172072e-09		NA	NA	NA
hsa-miR-34a-5p	SCN2B	1.9016323452565	1.43092834643601e-14	-4.29366513636715	3.96960287530702e-15	MirTarget;miRNATAP	-0.945153482826181	4.61845403658e-20		NA	NA	NA
hsa-miR-34a-5p	SEPT7	1.9016323452565	1.43092834643601e-14	-0.502994288413354	6.27947005227609e-06	miRNAWalker2_validate	-0.175711270561873	9.57221248839149e-18		NA	NA	NA
hsa-miR-34a-5p	SERPINB1	1.9016323452565	1.43092834643601e-14	-0.430266614782949	0.22057926715014	miRNAWalker2_validate	-0.255236455357005	0.000125132058089275		NA	NA	NA
hsa-miR-129-5p	SERPINE1	-0.524170159980738	0.222582956006346	-0.393407117230654	0.370425399232706	miRanda	-0.169701923663541	0.000735839704611328		NA	NA	NA
hsa-miR-148a-3p	SERPINE1	1.26728238710376	2.52325607402829e-06	-0.393407117230654	0.370425399232706	miRNATAP	-0.193994560455384	0.0132472864251105		NA	NA	NA
hsa-miR-148a-5p	SERPINE1	1.16173838132242	0.000148929299881612	-0.393407117230654	0.370425399232706	miRNATAP	-0.285071111266077	3.2328150503793e-05		NA	NA	NA
hsa-miR-2110	SERPINE1	1.16625590651194	6.4784195289885e-05	-0.393407117230654	0.370425399232706	miRNATAP	-0.312861484463966	5.27602364952907e-05		NA	NA	NA
hsa-miR-301a-3p	SERPINE1	2.81024345929638	2.29784847962242e-17	-0.393407117230654	0.370425399232706	miRNAWalker2_validate;miRTarBase	-0.298339721528262	3.88735440627883e-06		NA	NA	NA
hsa-miR-30b-5p	SERPINE1	0.800822374912712	0.000133601914525413	-0.393407117230654	0.370425399232706	MirTarget	-0.589742716683692	3.53023994480113e-09	25170877	miR-30b may function as a novel tumor suppressor gene in gastric cancer by targeting PAI-1 and regulating the apoptosis of cancer cells		gastric cancer
hsa-miR-30c-5p	SERPINE1	0.778774633108	0.000285599212429136	-0.393407117230654	0.370425399232706	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.50652750448866	2.38346715661289e-07		NA	NA	NA
hsa-miR-30d-5p	SERPINE1	0.675423997639582	0.00270618816039773	-0.393407117230654	0.370425399232706	miRNATAP	-0.643924984116999	3.16202278334948e-12		NA	NA	NA
hsa-miR-378a-5p	SERPINE1	0.223456081148306	0.386368843153575	-0.393407117230654	0.370425399232706	MirTarget	-0.404559892121807	7.98544569711981e-07		NA	NA	NA
hsa-miR-421	SERPINE1	1.17791565395543	6.78526676976629e-06	-0.393407117230654	0.370425399232706	miRanda	-0.395794324632837	7.58532570850472e-07		NA	NA	NA
hsa-miR-425-5p	SERPINE1	3.07071373939774	4.02947460586085e-25	-0.393407117230654	0.370425399232706	MirTarget;miRNATAP	-0.268582077948886	6.45365175266955e-05		NA	NA	NA
hsa-miR-590-3p	SERPINE1	2.59289455139753	1.03200520972022e-21	-0.393407117230654	0.370425399232706	miRanda	-0.275014479514724	0.000327361176519488		NA	NA	NA
hsa-miR-769-5p	SERPINE1	1.82023760596845	9.6815886564134e-14	-0.393407117230654	0.370425399232706	MirTarget;miRNATAP	-0.571996036825274	4.60171798625337e-12		NA	NA	NA
hsa-miR-942-5p	SERPINE1	2.35195531153712	5.45059325728841e-16	-0.393407117230654	0.370425399232706	MirTarget	-0.197923564863346	0.00510222008258954		NA	NA	NA
hsa-miR-34a-5p	SETD3	1.9016323452565	1.43092834643601e-14	-0.540709000480151	6.78781937310879e-07	miRNAWalker2_validate	-0.105521816340478	3.11891948841458e-07		NA	NA	NA
hsa-miR-34a-5p	SGPP1	1.9016323452565	1.43092834643601e-14	-0.148910476883497	0.606055761679441	miRNAWalker2_validate;MirTarget;miRNATAP	-0.216186309327403	7.537410867789e-05		NA	NA	NA
hsa-miR-34a-5p	SH3PXD2A	1.9016323452565	1.43092834643601e-14	-0.987155493438988	1.02406192375196e-05	MirTarget	-0.141178709095079	0.000996098283931466		NA	NA	NA
hsa-miR-34a-5p	SIK2	1.9016323452565	1.43092834643601e-14	-0.895905910195029	1.03810013473188e-10	mirMAP	-0.172243703359764	6.36234892738211e-11		NA	NA	NA
hsa-miR-34a-5p	SIRT1	1.9016323452565	1.43092834643601e-14	-1.03742756823581	3.19867751848926e-11	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.117141124440484	0.000108824317675673	25982144;21067862;20687223;22623155;23954321;26722316;25826085;27126903;26518892;18834855	5 Aminolevulinic acid mediated sonodynamic therapy induces anti tumor effects in malignant melanoma via p53 miR 34a Sirt1 axis; Therefore the p53 miR-34a and SIRT1 constituted a positive feedback loop;Sirt1 which is one of the target genes for miR-34a and related to drug-resistance was strikingly up-regulated in the 5-FU-resistant cells; The ectopic expression of miR-34a in the 5-FU-resistant cells inhibited growth as in the parental cells and attenuated the resistance to 5-FU through the down-regulation of Sirt1 and E2F3; These findings suggest that miR-34a targeting the Sirt1 and E2F3 genes could negatively regulate at least in part the resistance to 5-FU in human colorectal cancer DLD-1 cells;We aimed to elucidate the molecular mechanisms underlying paclitaxel resistance of hormone-refractory prostate cancer with a special focus on the roles of miR-34a and SIRT1; MiR-34a over-expression and SIRT1 knockdown attenuated paclitaxel resistance of PC3PR cells; Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Interestingly RES increased the intracellular expression level of miR-34a which down-regulated the target gene E2F3 and its downstream Sirt1 resulting in growth inhibition;miR 34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression; The role of miR-34a in regulating sirtuin 1 SIRT1 in prostate cancer remains unclear; The objective of the present study was to investigate the biological function and molecular mechanisms of miR-34a regulation of SIRT1 in human prostate cancer samples and the human prostate cancer cell line PC-3; Fresh prostate tissues were obtained from patients and the miR-34a expression in prostate cancer tissues was measured using reverse transcription-quantitative polymerase chain reaction RT-qPCR qPCR and western blotting were performed to assess the effects of miR-34a overexpression on SIRT1 regulation in PC-3 cells and the cell growth was assessed by Cell Counting Kit-8 CCK-8; SIRT1 expression levels in PC-3 cells with over-expression of miR-34a were significantly reduced compared with those in the negative control P<0.05; In conclusion miR-34a inhibits the human prostate cancer cell proliferation in part through the downregulation of SIRT1 expression;Dysregulation of the miR 34a SIRT1 axis inhibits breast cancer stemness; Sirtuin-1 SIRT1 is a direct target of miR-34a; Here we found low levels of miR-34a and high levels of SIRT1 in CD44+/CD24- breast cancer stem cells BCSCs; MiR-34a overexpression and knockdown of SIRT1 decreased proportion of BSCSs and mammosphere formation; In nude mice xenografts stable expression of miR-34a and silencing of SIRT1 reduced tumor burden; Taken together our results demonstrated that miR-34a inhibits proliferative potential of BCSCs in vitro and in vivo at least partially by downregulating SIRT1;In addition the present micellar system facilitated the escape of miR-34a from the endosome and release of DOX into the cell nucleus leading to the downregulation of silent information regulator 1 SIRT1 expression and inhibition of DU145 and PC3 androgen-independent prostate cancer cell proliferation;For example overexpressing miR-34a a master regulator of tumor suppression attenuates chemoresistance to 5-FU by downregulating silent information regulator 1 SIRT1 and E2F3;In PC3 cell ectopic expression of miR-34a decreased the SIRT1 mRNA and protein levels as well as protein levels of known direct target genes; Reporter assays revealed that miR-34a-induced SIRT1 inhibition occurred at the transcriptional but not post-transcriptional level despite the presence of a potential miR-34a binding site within its 3'-UTR	malignant trasformation;drug resistance;drug resistance;;;;;;drug resistance;	melanoma;colon cancer;prostate cancer;breast cancer;colon cancer;prostate cancer;breast cancer;prostate cancer;colorectal cancer;prostate cancer
hsa-miR-34a-5p	SLC16A2	1.9016323452565	1.43092834643601e-14	-1.53927355158781	4.3817377775803e-06	mirMAP	-0.556012879925461	2.31984858477906e-19		NA	NA	NA
hsa-miR-34a-5p	SLC2A13	1.9016323452565	1.43092834643601e-14	-1.18256435189023	3.80131152801412e-05	miRNATAP	-0.325842890406393	1.80520761231188e-09		NA	NA	NA
hsa-miR-34a-5p	SLC2A14	1.9016323452565	1.43092834643601e-14	-2.04597485691248	7.35967822773436e-07	miRNAWalker2_validate	-0.365242530470944	3.82878250764088e-06		NA	NA	NA
hsa-miR-34a-5p	SLC2A3	1.9016323452565	1.43092834643601e-14	-2.09454232135098	3.92772896271437e-08	miRNAWalker2_validate	-0.335781037210638	4.47080444346655e-06		NA	NA	NA
hsa-miR-34a-5p	SLC6A16	1.9016323452565	1.43092834643601e-14	-2.20802995506184	3.2208227755399e-06	miRNAWalker2_validate	-0.403679404075837	8.48916564623487e-06		NA	NA	NA
hsa-miR-34a-5p	SLC6A17	1.9016323452565	1.43092834643601e-14	0.941104200796897	0.0568131902197341	miRNATAP	-0.367577643108895	8.77000802331651e-05		NA	NA	NA
hsa-miR-34a-5p	SLC7A1	1.9016323452565	1.43092834643601e-14	0.0553385590912683	0.83891351896488	mirMAP	-0.232249878829794	6.0415270497118e-06		NA	NA	NA
hsa-miR-34a-5p	SLCO3A1	1.9016323452565	1.43092834643601e-14	-0.349114583112527	0.300053914964445	MirTarget;miRNATAP	-0.195823064603045	0.00221566399106474		NA	NA	NA
hsa-miR-34a-5p	SMAD4	1.9016323452565	1.43092834643601e-14	-0.586921155134023	3.52416916552263e-06	miRNATAP	-0.121709073519824	3.8975183335493e-07	22750848	Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a		glioblastoma
hsa-miR-34a-5p	SMAD7	1.9016323452565	1.43092834643601e-14	-1.18986730797292	6.37278457783496e-08	MirTarget	-0.136694424476981	0.00127398242742499		NA	NA	NA
hsa-miR-34a-5p	SNAP25	1.9016323452565	1.43092834643601e-14	-1.14591384974572	0.0327342558924054	miRNATAP	-0.477871557864455	2.46720878134202e-06		NA	NA	NA
hsa-miR-34a-5p	SNPH	1.9016323452565	1.43092834643601e-14	-0.856242399827214	0.00165958426767376	mirMAP	-0.211587898799019	4.32801701671779e-05		NA	NA	NA
hsa-miR-34a-5p	SNTB2	1.9016323452565	1.43092834643601e-14	-0.441658705547666	0.00100504578260347	miRNAWalker2_validate	-0.171129704303543	7.5691721860405e-12		NA	NA	NA
hsa-miR-34a-5p	SNX12	1.9016323452565	1.43092834643601e-14	-0.200376025433756	0.257087274836022	miRNAWalker2_validate;MirTarget;miRNATAP	-0.143477931409484	1.68526998883892e-05		NA	NA	NA
hsa-miR-34a-5p	SNX29	1.9016323452565	1.43092834643601e-14	-0.637224583441126	6.77957051876116e-05	mirMAP	-0.153182880006045	4.22118416813171e-07		NA	NA	NA
hsa-miR-34a-5p	SNX30	1.9016323452565	1.43092834643601e-14	0.0810480588629172	0.652515057244654	miRNATAP	-0.106469048066774	0.00179658484033176		NA	NA	NA
hsa-miR-34a-5p	SOX2	1.9016323452565	1.43092834643601e-14	-0.323595368728617	0.681514582034885	miRNAWalker2_validate;miRTarBase	-0.418653713804836	0.00524040301276666		NA	NA	NA
hsa-miR-34a-5p	SOX6	1.9016323452565	1.43092834643601e-14	-2.16170894059309	7.49520430040923e-06	miRNATAP	-0.359369643789747	0.000101272748769117		NA	NA	NA
hsa-miR-34a-5p	SPI1	1.9016323452565	1.43092834643601e-14	-0.303903678192015	0.447316474486497	miRNAWalker2_validate	-0.29884651506223	7.88009966070382e-05		NA	NA	NA
hsa-miR-34a-5p	SPRED1	1.9016323452565	1.43092834643601e-14	-0.64004595524649	0.00626859347930208	miRNATAP	-0.255133581450969	6.6069311768714e-09		NA	NA	NA
hsa-miR-34a-5p	SPTAN1	1.9016323452565	1.43092834643601e-14	-0.510431340463778	0.00153188209696753	miRNAWalker2_validate	-0.138432560381903	5.58887177696604e-06		NA	NA	NA
hsa-miR-34a-5p	SPTBN1	1.9016323452565	1.43092834643601e-14	-0.735351026844664	0.000347171300601555	miRNAWalker2_validate	-0.199718395817061	2.79500301041961e-07		NA	NA	NA
hsa-miR-34a-5p	STAC2	1.9016323452565	1.43092834643601e-14	-0.583414225007588	0.277040384550552	miRNATAP	-0.234173858268266	0.0220373398473181		NA	NA	NA
hsa-miR-34a-5p	STAT1	1.9016323452565	1.43092834643601e-14	0.542663454678779	0.0737713250641883	miRNAWalker2_validate	-0.236831607684438	3.76320893148253e-05		NA	NA	NA
hsa-miR-34a-5p	STC1	1.9016323452565	1.43092834643601e-14	-1.55340441030689	1.29077994156941e-05	miRNATAP	-0.223305585033756	0.00108351478165292		NA	NA	NA
hsa-miR-34a-5p	STK38L	1.9016323452565	1.43092834643601e-14	-0.765014874635487	4.35127290099018e-05	MirTarget	-0.204620628389829	6.85173806885803e-09		NA	NA	NA
hsa-miR-34a-5p	STRAP	1.9016323452565	1.43092834643601e-14	-0.0609987087335284	0.638521952110271	miRNAWalker2_validate	-0.101302148739036	3.37779250298755e-05		NA	NA	NA
hsa-miR-34a-5p	STRN3	1.9016323452565	1.43092834643601e-14	-0.694246317299341	2.23666142606823e-06	MirTarget;miRNATAP	-0.169613586220948	8.87394242222182e-10		NA	NA	NA
hsa-miR-34a-5p	STX17	1.9016323452565	1.43092834643601e-14	-0.343981391742685	0.00166799096480426	MirTarget	-0.100423965033157	1.0636596657868e-06		NA	NA	NA
hsa-miR-34a-5p	STX1B	1.9016323452565	1.43092834643601e-14	-0.831193288425681	0.0477395804955152	mirMAP	-0.376227781373039	2.09525210432239e-06		NA	NA	NA
hsa-miR-34a-5p	SYNE2	1.9016323452565	1.43092834643601e-14	-0.381691294548014	0.0787393265300737	miRNAWalker2_validate	-0.243208586454659	2.11811769371397e-09		NA	NA	NA
hsa-miR-34a-5p	SYT1	1.9016323452565	1.43092834643601e-14	-0.547551993916526	0.281961898919138	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.332297285704628	0.000581145710997762		NA	NA	NA
hsa-miR-34a-5p	TAF4B	1.9016323452565	1.43092834643601e-14	-0.440551340182907	0.163919692677726	miRNATAP	-0.377549070491061	1.61614730973031e-10		NA	NA	NA
hsa-miR-34a-5p	TBC1D16	1.9016323452565	1.43092834643601e-14	-0.000723386575430585	0.997052256137848	mirMAP	-0.167641168981214	5.44961881921373e-06		NA	NA	NA
hsa-miR-34a-5p	TCF12	1.9016323452565	1.43092834643601e-14	-0.437166250390586	0.00485294102410064	MirTarget;miRNATAP	-0.160477566684174	3.72213428026613e-08		NA	NA	NA
hsa-miR-34a-5p	TES	1.9016323452565	1.43092834643601e-14	-1.08685329583047	1.15308429217781e-07	miRNAWalker2_validate	-0.303863427252864	2.14973771165893e-15		NA	NA	NA
hsa-miR-34a-5p	TGM2	1.9016323452565	1.43092834643601e-14	-1.14690935857596	0.0144751654848477	miRNAWalker2_validate	-0.596492455291748	9.16055361131472e-12		NA	NA	NA
hsa-miR-34a-5p	TMCC3	1.9016323452565	1.43092834643601e-14	-1.35239851980287	4.93606931842352e-05	MirTarget;miRNATAP	-0.3988923386118	2.02559123658569e-10		NA	NA	NA
hsa-miR-34a-5p	TMEM200B	1.9016323452565	1.43092834643601e-14	-1.42414763286868	0.00190297304643915	miRNATAP	-0.410404695596541	2.35619773831901e-06		NA	NA	NA
hsa-miR-34a-5p	TMEM55A	1.9016323452565	1.43092834643601e-14	-1.20928980478551	1.66704876794806e-07	MirTarget	-0.341642443217465	2.54141966441908e-15		NA	NA	NA
hsa-miR-34a-5p	TMEM63C	1.9016323452565	1.43092834643601e-14	0.808209141397143	0.155209732021727	mirMAP	-0.27005516911793	0.0126816114622612		NA	NA	NA
hsa-miR-34a-5p	TMOD2	1.9016323452565	1.43092834643601e-14	-1.02377830752032	1.97345844232229e-05	miRNAWalker2_validate	-0.323217572186162	5.85945396791463e-13		NA	NA	NA
hsa-miR-34a-5p	TNPO1	1.9016323452565	1.43092834643601e-14	-0.196064925187165	0.136005283860513	miRNAWalker2_validate	-0.141302014792235	8.58901974747901e-09		NA	NA	NA
hsa-miR-34a-5p	TP53INP2	1.9016323452565	1.43092834643601e-14	-2.21250190189587	4.52774358230457e-20	MirTarget	-0.311337475321648	3.80277585826934e-11		NA	NA	NA
hsa-miR-34a-5p	TPM1	1.9016323452565	1.43092834643601e-14	-2.65530585768087	2.50185615635583e-17	miRNAWalker2_validate	-0.600882326868458	1.44424511680119e-24		NA	NA	NA
hsa-miR-34a-5p	TPPP	1.9016323452565	1.43092834643601e-14	-4.06681960647858	1.27319129789239e-22	miRNAWalker2_validate;MirTarget	-0.392068927494331	2.17448465996609e-06		NA	NA	NA
hsa-miR-34a-5p	TSHZ2	1.9016323452565	1.43092834643601e-14	-2.36271880423433	2.34708957144416e-08	miRNATAP	-0.407694855030008	4.94025396963828e-07		NA	NA	NA
hsa-miR-34a-5p	TSPAN11	1.9016323452565	1.43092834643601e-14	-2.3587553580542	3.63548653474133e-10	mirMAP	-0.222589739531513	0.00233273214432045		NA	NA	NA
hsa-miR-34a-5p	TTBK1	1.9016323452565	1.43092834643601e-14	0.592902015109751	0.108572420184107	mirMAP	-0.167312139247633	0.0175099183374356		NA	NA	NA
hsa-miR-34a-5p	TXNRD1	1.9016323452565	1.43092834643601e-14	-1.12063019657297	0.000151225388551436	miRNAWalker2_validate	-0.45525586967837	8.2401097206679e-17		NA	NA	NA
hsa-miR-34a-5p	UBR4	1.9016323452565	1.43092834643601e-14	-0.481351375109417	7.46877462227738e-06	miRNAWalker2_validate	-0.117170347788259	6.73951838653931e-09		NA	NA	NA
hsa-miR-34a-5p	VCL	1.9016323452565	1.43092834643601e-14	-1.42195933102912	9.04222123827734e-13	miRNAWalker2_validate;miRNATAP	-0.246989410891453	9.46844298497881e-11		NA	NA	NA
hsa-miR-34a-5p	WASF1	1.9016323452565	1.43092834643601e-14	0.514886362846972	0.0399579941525439	MirTarget;miRNATAP	-0.280141476290894	2.41498973472405e-09		NA	NA	NA
hsa-miR-34a-5p	WASF2	1.9016323452565	1.43092834643601e-14	-0.801854983583159	1.10831629491092e-05	miRNAWalker2_validate;mirMAP	-0.205707713726092	2.31658772645909e-09		NA	NA	NA
hsa-miR-34a-5p	WDFY4	1.9016323452565	1.43092834643601e-14	-1.52835958077685	0.00208595788951407	mirMAP	-0.450629510294551	1.6756200761721e-06		NA	NA	NA
hsa-miR-34a-5p	WTIP	1.9016323452565	1.43092834643601e-14	-0.143470050488438	0.575976441100554	mirMAP	-0.110268889910385	0.0238714346536238		NA	NA	NA
hsa-miR-34a-5p	XYLT1	1.9016323452565	1.43092834643601e-14	-1.15680000822774	0.00273654109630901	MirTarget;miRNATAP	-0.249465213783621	0.000702853207918648		NA	NA	NA
hsa-miR-34a-5p	ZDHHC15	1.9016323452565	1.43092834643601e-14	-2.821890119317	1.80193983474815e-08	MirTarget	-0.539909556786311	1.69475923776528e-08		NA	NA	NA
hsa-miR-34a-5p	ZFHX4	1.9016323452565	1.43092834643601e-14	-2.72243653694716	1.46650038380412e-06	MirTarget;miRNATAP	-0.904347969530743	6.19334195647492e-18		NA	NA	NA
hsa-miR-34a-5p	ZFR	1.9016323452565	1.43092834643601e-14	-0.244084007386841	0.0323653934875649	miRNAWalker2_validate	-0.123658212702121	6.16140246348229e-09		NA	NA	NA
hsa-miR-34a-5p	ZHX2	1.9016323452565	1.43092834643601e-14	-1.0113703267308	3.68498992423451e-09	MirTarget	-0.177218657756695	6.38669235356367e-08		NA	NA	NA
hsa-miR-34a-5p	ZNF281	1.9016323452565	1.43092834643601e-14	0.0416620203780278	0.888110347621826	MirTarget;miRNATAP	-0.301625657038341	5.62977700534027e-08		NA	NA	NA
hsa-miR-34a-5p	ZNF532	1.9016323452565	1.43092834643601e-14	-0.642348594400126	0.00482300004408463	miRNATAP	-0.347457661422715	1.21370996999873e-16		NA	NA	NA
hsa-miR-34a-5p	ZNF641	1.9016323452565	1.43092834643601e-14	-0.687739592791494	0.0034857735492281	MirTarget	-0.213534611469374	1.62184062991974e-06		NA	NA	NA