miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-145-5p	ADM2	-1.4795885711477	6.47308361543414e-16	1.7229047600607	3.16835442282685e-11	mirMAP	-0.169878628502872	0.0129484299634377		NA	NA	NA
hsa-miR-145-5p	ALDH3A1	-1.4795885711477	6.47308361543414e-16	1.59783536227	0.0147986570586824	miRNAWalker2_validate	-0.421250352530411	0.0126242297102388		NA	NA	NA
hsa-miR-145-5p	ANGPT2	-1.4795885711477	6.47308361543414e-16	1.15268392731739	7.05586126458027e-10	MirTarget;miRNATAP	-0.196630651852303	5.50134414980236e-05	24384875;27570490	miR 145 functions as tumor suppressor and targets two oncogenes ANGPT2 and NEDD9 in renal cell carcinoma; We further validated those miR-145 targets two oncogenes ANGPT2 and NEDD9 in RCC;MiR 145 functions as a tumor suppressor via regulating angiopoietin 2 in pancreatic cancer cells; The direct action of miR-145 on Ang-2 was predicted by TargetScan and confirmed by luciferase report assay; The expression level of miR-145 was significantly lower and the expression levels of Ang-2 mRNA and protein was significantly higher in the more aggressive pancreatic cancer cells MiaPaCa-2 and Panc-1 when compared to that in BxPC3 cells; Overexpression of miR-145 in the BxPC3 MiaPaCa-2 and Panc-1 cells suppressed the cell invasion and colony formation ability and the expression level of Ang-2 protein in MiaPaCa-2 and Panc-1 cells was also suppressed after pre-miR-145 transfection; Intratumoral delivery of miR-145 inhibited the growth of pancreatic cancer xenografts and angiogenesis in vivo and also suppressed the expression level of angiopoietin-2 protein; MiR-145 functions as a tumor suppressor in pancreatic cancer cells by targeting Ang-2 for translation repression and thus suppresses pancreatic cancer cell invasion and growth which suggests that restoring of miR-145 may be a potential therapeutic target for pancreatic cancer	;	kidney renal cell cancer;pancreatic cancer
hsa-miR-145-5p	ANKRD52	-1.4795885711477	6.47308361543414e-16	1.45719998646575	1.747377108051e-36	miRNATAP	-0.197085056637391	5.90538468792844e-10		NA	NA	NA
hsa-miR-145-5p	APH1A	-1.4795885711477	6.47308361543414e-16	0.326774606842128	7.1443884106445e-06	miRNAWalker2_validate	-0.104983163859547	1.37106129803436e-08		NA	NA	NA
hsa-miR-145-5p	ATXN7L3	-1.4795885711477	6.47308361543414e-16	0.698895357070855	3.23244219063052e-16	miRNATAP	-0.11885837536839	1.20279951756195e-07		NA	NA	NA
hsa-miR-145-5p	BNIP3	-1.4795885711477	6.47308361543414e-16	-0.56708142845002	7.502879446291e-06	miRNAWalker2_validate;miRTarBase	-0.102031222082163	0.00183773459195118	20332243	Artificial overexpression of miR145 by using adenoviral vectors in prostate cancer PC-3 and DU145 cells significantly downregulated BNIP3 together with the upregulation of AIF reduced cell growth and increased cell death; Analysis of prostate cancer n = 134 and benign prostate n = 83 tissue sample showed significantly decreased miR145 and increased BNIP3 expression in prostate cancer P < 0.001 particularly in those with tumor progression and both molecular changes were associated with unfavorable outcome	progression	prostate cancer
hsa-miR-145-5p	BRWD3	-1.4795885711477	6.47308361543414e-16	0.097389343514537	0.536703137535803	miRNATAP	-0.113245543675398	0.00503839188312108		NA	NA	NA
hsa-miR-145-5p	BSN	-1.4795885711477	6.47308361543414e-16	0.943588815475765	2.35563209281755e-05	miRNATAP	-0.271542646074543	2.15319194909084e-06		NA	NA	NA
hsa-miR-145-5p	CDK4	-1.4795885711477	6.47308361543414e-16	0.667631464196621	2.00897661385551e-11	miRNAWalker2_validate;miRTarBase	-0.153089865179612	2.59222750442516e-09	21092188	Furthermore we found that CDK4 was regulated by miR-145 in cell cycle control		lung squamous cell cancer
hsa-miR-145-5p	CEP78	-1.4795885711477	6.47308361543414e-16	0.348753889923129	0.00103957272277983	mirMAP	-0.107147503186646	8.35016545422898e-05		NA	NA	NA
hsa-miR-145-5p	COMMD5	-1.4795885711477	6.47308361543414e-16	0.838104876299824	1.81629659072012e-13	MirTarget	-0.158374405731816	9.69916467666398e-08		NA	NA	NA
hsa-miR-145-5p	COMMD9	-1.4795885711477	6.47308361543414e-16	0.249145378307771	0.00304963862513706	MirTarget	-0.102676427844162	1.55463217892546e-06		NA	NA	NA
hsa-miR-145-5p	DNAJB11	-1.4795885711477	6.47308361543414e-16	0.853927523668179	2.13811491658948e-21	miRNATAP	-0.144186737048418	1.37168338108303e-09		NA	NA	NA
hsa-miR-145-5p	DNMT3B	-1.4795885711477	6.47308361543414e-16	1.61793226634891	7.24162651287187e-19	MirTarget	-0.229217111222152	2.31179911359625e-06	24071015;25749421	In univariate analysis the combination of DNMT3B overexpression and miR-145 or miR-143 down-regulation was more powerful in predicting shorter survival P < .05 than use of the biomarkers individually P > .05; DNMT3B might be a potential target of miR-145 and miR-143 in ECs; Furthermore the combined miR-145 or miR-143 and DNMT3B status may have a prognostic impact on ECs;It was found that miR-145 upregulates while DNMT3b downregulates in PC3 cells; Responses of the miR-145 and DNMT3b to irradiation are a negative correlation; We also found that either overexpression of miR-145 or knockdown of DNMT3b sensitized prostate cancer cells to X-ray radiation	poor survival;drug resistance	endometrial cancer;prostate cancer
hsa-miR-145-5p	EFNA3	-1.4795885711477	6.47308361543414e-16	1.74857523726189	1.89670377349898e-17	miRNATAP	-0.27893442549449	2.94867753331604e-07		NA	NA	NA
hsa-miR-145-5p	ERF	-1.4795885711477	6.47308361543414e-16	0.136389282321141	0.149284526160661	MirTarget;miRNATAP	-0.111839765842692	3.1225859006542e-06		NA	NA	NA
hsa-miR-145-5p	ESCO2	-1.4795885711477	6.47308361543414e-16	1.79795026822267	1.40192339916998e-14	MirTarget	-0.350922169188005	9.21748412277187e-09		NA	NA	NA
hsa-miR-145-5p	FAM104A	-1.4795885711477	6.47308361543414e-16	0.382548867340036	2.14628142056169e-09	MirTarget	-0.135312338302984	2.50383248700923e-17		NA	NA	NA
hsa-miR-145-5p	FAM134A	-1.4795885711477	6.47308361543414e-16	0.31241986271071	6.33121602143484e-06	MirTarget	-0.106729178144281	1.11245752196109e-09		NA	NA	NA
hsa-miR-145-5p	FAM49B	-1.4795885711477	6.47308361543414e-16	0.706283783396553	6.55052138725098e-10	MirTarget	-0.110874561653967	0.000199701932460406		NA	NA	NA
hsa-miR-145-5p	FLRT1	-1.4795885711477	6.47308361543414e-16	1.04778256475981	1.23585074123518e-06	MirTarget	-0.171014510051033	0.00230060297365636		NA	NA	NA
hsa-miR-145-5p	GATC	-1.4795885711477	6.47308361543414e-16	0.0603112190540133	0.626598180192356	MirTarget	-0.115253801141523	0.00026725465713453		NA	NA	NA
hsa-miR-145-5p	GGT7	-1.4795885711477	6.47308361543414e-16	0.0215459775862437	0.846767823094613	MirTarget;miRNATAP	-0.105884657657048	0.000193581797365303		NA	NA	NA
hsa-miR-145-5p	GPD2	-1.4795885711477	6.47308361543414e-16	0.404567318088859	0.000374344403235026	miRNATAP	-0.103572173689072	0.000393560251461817		NA	NA	NA
hsa-miR-145-5p	H2AFX	-1.4795885711477	6.47308361543414e-16	1.27255391641288	1.24796507414281e-17	MirTarget;miRNATAP	-0.247226192426532	2.41220424161681e-10		NA	NA	NA
hsa-miR-145-5p	HIC2	-1.4795885711477	6.47308361543414e-16	0.940776893137958	6.46839631810595e-09	miRNATAP	-0.201910123438837	1.50163181272437e-06		NA	NA	NA
hsa-miR-145-5p	HLTF	-1.4795885711477	6.47308361543414e-16	0.436017063558853	0.000150608395187135	miRNAWalker2_validate	-0.128421100653523	1.3235123890904e-05	25666710	We show that miR-145 targets the DNA damage repair-associated gene Helicase-like transcription factor HLTF which is involved in radio-resistance	drug resistance	cervical and endocervical cancer
hsa-miR-145-5p	IRS1	-1.4795885711477	6.47308361543414e-16	-0.221383948238947	0.137544848662312	miRNAWalker2_validate;miRTarBase;MirTarget	-0.14713831440926	0.000110683183121748	22431718;24690171;24762580	Luciferase reporter assay further verified direct target association of miR-145 to specific sites of the IRS1 and IRS2 3'-untranslated regions;MicroRNA 145 suppresses hepatocellular carcinoma by targeting IRS1 and its downstream Akt signaling; We verified IRS1 as a direct target of miR-145 using Western blotting and luciferase reporter assay; Further the restoration of miR-145 in HCC cell lines suppressed cancer cell growth owing to down-regulated IRS1 expression and its downstream Akt/FOXO1 signaling; Our results demonstrated that miR-145 could inhibit HCC through targeting IRS1 and its downstream signaling implicating the loss of miR-145 regulation may be a potential molecular mechanism causing aberrant oncogenic signaling in HCC;IRS-1 was identified as a potential target of miR-145 by dual luciferase reporter assay; Knocking down of IRS-1 had similar effect as overexpression of miR-145 miR-145 might act as a tumor suppressor in uveal melanoma and downregulation of the target IRS-1 might be a potential mechanism	;;	liver cancer;liver cancer;melanoma
hsa-miR-145-5p	MAGOHB	-1.4795885711477	6.47308361543414e-16	0.39509058223687	1.17195156112121e-05	MirTarget	-0.106370939048142	4.11350109311863e-06		NA	NA	NA
hsa-miR-145-5p	MAP2K6	-1.4795885711477	6.47308361543414e-16	0.144298636980369	0.55112353687976	miRNAWalker2_validate	-0.148422069176077	0.0169211009425297		NA	NA	NA
hsa-miR-145-5p	MBNL3	-1.4795885711477	6.47308361543414e-16	-0.597245834128655	0.0142379871483953	miRNATAP	-0.194260062903799	0.00191805665901708		NA	NA	NA
hsa-miR-145-5p	MMP1	-1.4795885711477	6.47308361543414e-16	1.71035043682945	7.54233897842319e-06	miRNAWalker2_validate	-0.212014152453586	0.0327763086187393		NA	NA	NA
hsa-miR-145-5p	NEDD4L	-1.4795885711477	6.47308361543414e-16	0.864887679249782	8.63340597856756e-11	miRNATAP	-0.226798274128155	3.48443162842019e-11		NA	NA	NA
hsa-miR-145-5p	NRAS	-1.4795885711477	6.47308361543414e-16	0.301156333096785	0.000285671613438218	miRNAWalker2_validate;MirTarget;miRNATAP	-0.120395847533196	1.03194548202048e-08	26973415	miR-145 expression was significantly downregulated in colon cancer tissues with its expression in normal colonic tissues being 4-5-fold higher two sample t test P < 0.05 whereas N-ras expression showed the opposite trend		colon cancer
hsa-miR-145-5p	NUDT1	-1.4795885711477	6.47308361543414e-16	1.54647799393357	9.79342763312994e-22	miRTarBase	-0.230048769240889	9.45867065612913e-08	21289483	MiR 145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1; The mRNA expressions of EGFR and NUDT1 were significantly downregulated after miR-145 transfection in human lung adenocarcinoma cells; Our results demonstrated miR-145 in the negative regulation of EGFR and NUDT1 expressions at both mRNA and protein levels; Upregulation of miR-145 appeared to be an important gene regulation mechanism for the proliferation of lung adenocarcinoma cells and it correlated strongly with the downregulation of EGFR and NUDT1; Our findings provided new insight into the complex regulating pathway comprising of miR-145 EGFR NUDT1 and other unknown factors which function in cell proliferation but not in apoptosis		lung cancer
hsa-miR-145-5p	ONECUT2	-1.4795885711477	6.47308361543414e-16	0.120890541524141	0.551384233388767	mirMAP;miRNATAP	-0.24786103208335	1.51819604606623e-06		NA	NA	NA
hsa-miR-145-5p	PAK4	-1.4795885711477	6.47308361543414e-16	0.332066945941027	0.000554855795687645	miRNAWalker2_validate;miRTarBase	-0.118651468400972	1.29791519135524e-06	23499891	We further demonstrated that miR-145 directly targeted catenin δ-1 contributing to the aberrant translocation of β-catenin through impaired nuclear shuttling with p21-activated kinase 4 PAK4		colon cancer
hsa-miR-145-5p	PAN2	-1.4795885711477	6.47308361543414e-16	-0.124303685559878	0.24512533602074	MirTarget;miRNATAP	-0.123876289466467	5.05781336675732e-06		NA	NA	NA
hsa-miR-145-5p	PAQR9	-1.4795885711477	6.47308361543414e-16	0.136400501110993	0.5121608638586	MirTarget	-0.200402389306194	0.000162310204296034		NA	NA	NA
hsa-miR-145-5p	PIGF	-1.4795885711477	6.47308361543414e-16	0.461843025560526	5.00720811835492e-10	miRNAWalker2_validate;MirTarget	-0.122104310407385	1.24852987743285e-10		NA	NA	NA
hsa-miR-145-5p	POU5F1	-1.4795885711477	6.47308361543414e-16	1.70826814451959	3.08759036385542e-10	miRNAWalker2_validate	-0.28116277943052	7.30785404553878e-05		NA	NA	NA
hsa-miR-145-5p	RAB11FIP4	-1.4795885711477	6.47308361543414e-16	1.54437373311846	7.02562100479325e-17	MirTarget	-0.186591780130354	0.000149212740508188		NA	NA	NA
hsa-miR-145-5p	RNF207	-1.4795885711477	6.47308361543414e-16	0.828705825765608	2.83913644606982e-10	MirTarget	-0.142373370880354	3.20402601721353e-05		NA	NA	NA
hsa-miR-145-5p	RNF216	-1.4795885711477	6.47308361543414e-16	0.524262170688949	6.99637163968196e-13	MirTarget;miRNATAP	-0.121520852924876	1.01351446484376e-10		NA	NA	NA
hsa-miR-145-5p	RPS6KB1	-1.4795885711477	6.47308361543414e-16	0.0405513114293425	0.579068505304799	MirTarget;miRNATAP	-0.109724019103871	2.07298188703538e-09	24157791	MiR 145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1; MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3'UTRs; Importantly the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145 respectively; Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1 functioning as a tumor suppressor		ovarian cancer
hsa-miR-145-5p	SCAMP3	-1.4795885711477	6.47308361543414e-16	1.20056451579604	1.63329457117019e-29	MirTarget;miRNATAP	-0.180821092204003	3.2493487591107e-10		NA	NA	NA
hsa-miR-145-5p	SLC1A4	-1.4795885711477	6.47308361543414e-16	0.587017438973827	1.90599459760694e-05	MirTarget	-0.221974664122985	1.8846965246477e-10		NA	NA	NA
hsa-miR-145-5p	SNX15	-1.4795885711477	6.47308361543414e-16	0.572778806079485	3.120794837269e-10	miRNATAP	-0.15245259718236	6.11625813661806e-11		NA	NA	NA
hsa-miR-145-5p	SNX27	-1.4795885711477	6.47308361543414e-16	0.701282370576235	4.48665293424922e-15	MirTarget;miRNATAP	-0.118723174339915	4.0542136039993e-07		NA	NA	NA
hsa-miR-145-5p	SOCS7	-1.4795885711477	6.47308361543414e-16	1.23630045260618	2.28814323600538e-14	miRNAWalker2_validate	-0.201080343209046	2.31433808114246e-06	23392170	socs7 a target gene of microRNA 145 regulates interferon β induction through STAT3 nuclear translocation in bladder cancer cells; Then we focused on the suppressor of cytokine signaling 7 socs7 whose expression level was upregulated in bladder cancer cells compared with its level in normal human urothelial cells as a putative target gene involved in IFN-β induction by miR-145; Expectedly exogenous miR-145 decreased the expression level of SOCS7 and socs7-silencing enhanced IFN-β induction by transfection with a TLR3 ligand polyinosinic acid-polycytidylic acid PIC; The results of a luciferase reporter assay revealed that miR-145 targeted socs7; In conclusion the machinery of IFN-β induction through the regulation of SOCS7 by miR-145 was closely associated with the induction of apoptosis; Moreover exogenous miR-145 promoted IFN-β induction by targeting socs7 which resulted in the nuclear translocation of STAT3		bladder cancer
hsa-miR-145-5p	SOX2	-1.4795885711477	6.47308361543414e-16	0.957482238879068	0.017078375832613	miRNAWalker2_validate;miRTarBase	-0.232281038843592	0.0247688875246843	20382729;21211035;22098779;25951106;22835608	Finally we provide evidence that EWS-FLI-1 and miRNA-145 function in a mutually repressive feedback loop and identify their common target gene SOX2 in addition to miRNA145 itself as key players in ESFT cell differentiation and tumorigenicity;We also show that miR-145 and SOX2 form a double negative feedback loop in GBM cells potentially creating a bistable system in GBM cells;In this study our miRNA/mRNA-microarray and RT-PCR analysis showed that the expression of miR145 a tumor-suppressive miRNA is inversely correlated with the levels of Oct4 and Sox2 in GBM-CD133+ cells and malignant glioma specimens; We demonstrated that miR145 negatively regulates GBM tumorigenesis by targeting Oct4 and Sox2 in GBM-CD133+;Overexpression of miR 145 5p inhibits proliferation of prostate cancer cells and reduces SOX2 expression; We proposed that miR-145-5p being an important regulator of SOX2 carries a crucial role in PCa tumorigenesis;miR-145 regulates SOX2 and OCT4 translation and p53 regulates miR-145 expression	differentiation;;malignant trasformation;tumorigenesis;tumorigenesis;	sarcoma;glioblastoma;glioblastoma;prostate cancer;lung squamous cell cancer
hsa-miR-145-5p	SPATS2	-1.4795885711477	6.47308361543414e-16	1.59671382425823	4.98846564542915e-42	MirTarget	-0.250785060922859	1.06397318915935e-14		NA	NA	NA
hsa-miR-145-5p	SRGAP2	-1.4795885711477	6.47308361543414e-16	0.77156783154035	3.52407714516935e-11	MirTarget	-0.121484336463963	6.57611803895429e-05		NA	NA	NA
hsa-miR-145-5p	TBC1D16	-1.4795885711477	6.47308361543414e-16	1.09783247128337	3.62886274986965e-17	mirMAP	-0.173524018120598	4.61025704137037e-07		NA	NA	NA
hsa-miR-145-5p	TPR	-1.4795885711477	6.47308361543414e-16	0.602347702749365	6.08762705780715e-11	MirTarget	-0.118223482098123	7.41247555205619e-07		NA	NA	NA
hsa-miR-145-5p	UNC119B	-1.4795885711477	6.47308361543414e-16	1.21392832041535	7.88210718787103e-18	MirTarget	-0.139980838221639	0.000197568905468616		NA	NA	NA
hsa-miR-145-5p	USP31	-1.4795885711477	6.47308361543414e-16	0.3853853894618	0.000159436643509761	MirTarget;miRNATAP	-0.104143045184037	6.96150209574054e-05		NA	NA	NA
hsa-miR-145-5p	UXS1	-1.4795885711477	6.47308361543414e-16	0.88738455729785	4.09760300351806e-24	miRNATAP	-0.129682072826299	3.13796219786214e-08		NA	NA	NA
hsa-miR-145-5p	VPS54	-1.4795885711477	6.47308361543414e-16	0.349280913555388	5.72682991930042e-05	MirTarget;miRNATAP	-0.130123190450618	3.38745609792403e-09		NA	NA	NA
hsa-miR-145-5p	ZBTB40	-1.4795885711477	6.47308361543414e-16	1.05248854418575	1.34458961008934e-27	mirMAP	-0.143256143261436	4.19703951997417e-08		NA	NA	NA
hsa-miR-145-5p	ZC3H3	-1.4795885711477	6.47308361543414e-16	1.0612730707833	1.57569638197004e-20	MirTarget	-0.210122970635626	2.51228172607063e-12		NA	NA	NA
hsa-miR-145-5p	ZDHHC9	-1.4795885711477	6.47308361543414e-16	0.264047104235033	0.0103896324528519	MirTarget;miRNATAP	-0.109858992637807	2.92505556026386e-05		NA	NA	NA
hsa-miR-145-5p	ZRANB3	-1.4795885711477	6.47308361543414e-16	0.122975016052876	0.435049944476466	MirTarget	-0.100278372504392	0.0130630192379254		NA	NA	NA