miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-107 ACVR1 0.678998026350662 2.56224148930538e-16 -0.462938675109919 4.22826789612895e-13 miRanda -0.341475890592561 4.28612624303003e-42 NA NA NA hsa-let-7d-5p ACVR1C 0.410958462607207 6.07808182756787e-06 -5.20071129736289 8.81931099882978e-104 MirTarget;miRNATAP -0.382116715205794 0.00021701935831798 NA NA NA hsa-let-7e-5p ACVR1C 0.261471269338985 0.00191077095550257 -5.20071129736289 8.81931099882978e-104 MirTarget;miRNATAP -0.391129535622582 0.000478036013006995 NA NA NA hsa-miR-181a-5p ACVR1C 0.635863607630183 6.72486918157744e-11 -5.20071129736289 8.81931099882978e-104 miRNATAP -0.620562379709194 5.89125073509107e-11 NA NA NA hsa-miR-181b-5p ACVR1C 1.22749257795094 1.21998198830919e-27 -5.20071129736289 8.81931099882978e-104 miRNATAP -0.736387159640416 1.1522673578888e-20 NA NA NA hsa-miR-181c-5p ACVR1C 0.574847839298605 4.51287502066478e-07 -5.20071129736289 8.81931099882978e-104 miRNATAP -0.582612994724267 6.82133958480936e-13 NA NA NA hsa-miR-200b-3p ACVR1C 2.11744072703209 1.66710572104191e-43 -5.20071129736289 8.81931099882978e-104 TargetScan -0.692003711219126 2.03439748086501e-35 NA NA NA hsa-miR-331-5p ACVR1C 0.682437632502949 4.10871642662371e-11 -5.20071129736289 8.81931099882978e-104 miRNATAP -0.604316750970958 1.40966126146655e-11 NA NA NA hsa-miR-429 ACVR1C 2.84108892259147 3.88520896426515e-64 -5.20071129736289 8.81931099882978e-104 PITA;miRanda;miRNATAP -0.697810047692677 7.01989078734797e-46 NA NA NA hsa-miR-590-3p ACVR1C 1.27438512890514 1.03164723481469e-23 -5.20071129736289 8.81931099882978e-104 miRanda -0.580497974664095 4.97336103597514e-15 NA NA NA hsa-miR-590-5p ACVR1C 0.746515607868274 8.51300479640125e-09 -5.20071129736289 8.81931099882978e-104 PITA;miRanda -0.445957185891423 4.05699479656914e-10 NA NA NA hsa-miR-98-5p ACVR1C 0.656336869298973 9.03113188590466e-15 -5.20071129736289 8.81931099882978e-104 MirTarget -0.793231535265132 2.56641262477936e-13 NA NA NA hsa-miR-15a-5p ACVR2A 0.812445324157528 4.50263417099822e-20 -0.964184609321378 1.30052843588401e-37 MirTarget;miRNATAP -0.36516801924186 2.81837633955843e-37 NA NA NA hsa-miR-185-5p ACVR2A 0.482334746589337 3.68475879959415e-09 -0.964184609321378 1.30052843588401e-37 miRNATAP -0.307434790887798 1.14081881563322e-21 NA NA NA hsa-miR-429 BMP2 2.84108892259147 3.88520896426515e-64 -2.65857867772634 6.10527487782614e-50 miRNATAP -0.40826129557167 7.17935100433753e-32 NA NA NA hsa-miR-590-3p BMP4 1.27438512890514 1.03164723481469e-23 -1.10149092310353 5.54349856867319e-09 miRanda -0.488786644087842 1.20391215808401e-21 NA NA NA hsa-miR-340-5p BMP5 1.0857159627596 4.94471062546756e-24 -4.21260848297834 3.39987684895973e-39 mirMAP -0.301115943990931 0.00419713980656556 NA NA NA hsa-miR-590-3p BMP5 1.27438512890514 1.03164723481469e-23 -4.21260848297834 3.39987684895973e-39 mirMAP -0.431944392599325 2.99721483164888e-06 NA NA NA hsa-miR-30c-5p BMP7 -0.393222674580066 8.06961465717306e-05 -0.568347328167421 0.0198013961935752 mirMAP;miRNATAP -0.352978199901424 2.48460436378243e-05 NA NA NA hsa-miR-342-3p BMP7 1.21944481975657 6.81914373001202e-19 -0.568347328167421 0.0198013961935752 miRNAWalker2_validate;miRTarBase;miRanda -0.39939088547044 1.28747468011685e-11 NA NA NA hsa-miR-30e-3p BMP8A -0.708952170420973 1.05866470714978e-22 2.5531168368725 9.36184416259286e-78 MirTarget -0.532592839026743 1.53477893028116e-14 NA NA NA hsa-miR-125b-5p BMPR1B -1.94393269763542 2.78180543229264e-58 2.3325512314431 1.87054528568578e-09 miRNAWalker2_validate;miRTarBase;MirTarget -0.523279943087425 3.82265313853702e-07 19738052;21556765 A risk variant in an miR 125b binding site in BMPR1B is associated with breast cancer pathogenesis; Furthermore luciferase reporter assays and overexpression of miR-125b-mimics combined with quantitative reverse transcription-PCR showed that BMPR1B transcript is a direct target of miR-125b and that miR-125b differentially regulates the C and T alleles of rs1434536; These results suggest that allele-specific regulation of BMPR1B by miR-125b explains the observed disease risk;Our findings show that rs1434536 in the 3'UTR of BMPR1B gene affects the binding ability of miR-125b to BMPR1B mRNA and contributes to the genetic predisposition to localized prostate cancer and patients aged>70 years ; breast cancer;prostate cancer hsa-miR-130a-3p BMPR1B -1.15024914519431 6.51290317952496e-19 2.3325512314431 1.87054528568578e-09 miRNATAP -0.468510027326227 3.72612678298247e-06 NA NA NA hsa-miR-130b-3p BMPR1B 1.38122163823846 1.00932179737836e-26 2.3325512314431 1.87054528568578e-09 miRNATAP -0.330771696537828 0.00111424679509253 NA NA NA hsa-miR-140-3p BMPR1B -1.25844395244141 5.29222651039892e-33 2.3325512314431 1.87054528568578e-09 MirTarget -0.897617718710942 1.46772814243533e-13 NA NA NA hsa-miR-142-5p BMPR1B 1.16509303143593 1.96641162209073e-13 2.3325512314431 1.87054528568578e-09 mirMAP -0.444165525578716 8.90675105128216e-08 NA NA NA hsa-miR-146b-5p BMPR1B 0.631041661167954 6.20366593452965e-08 2.3325512314431 1.87054528568578e-09 miRanda -0.763779914564347 1.66236814877754e-11 NA NA NA hsa-miR-150-5p BMPR1B -0.832049526091211 3.45299201139224e-05 2.3325512314431 1.87054528568578e-09 MirTarget -0.447906956063762 1.00992000293386e-11 NA NA NA hsa-miR-23a-3p BMPR1B -0.217176729033818 0.00962615056202409 2.3325512314431 1.87054528568578e-09 mirMAP -0.54134602392377 0.000777327916413561 NA NA NA hsa-miR-24-3p BMPR1B -0.120123317289941 0.21432376743243 2.3325512314431 1.87054528568578e-09 miRNATAP -0.924083329815397 2.27189205259187e-11 NA NA NA hsa-miR-26a-5p BMPR1B -0.481180084102235 1.82368246174758e-10 2.3325512314431 1.87054528568578e-09 mirMAP -0.502628260270685 0.004703613816135 NA NA NA hsa-miR-374a-5p BMPR1B -0.239709888246804 0.00309819667153627 2.3325512314431 1.87054528568578e-09 MirTarget -1.34531949769775 2.36721949756409e-16 NA NA NA hsa-miR-374b-5p BMPR1B -0.466781429946153 1.17238311619116e-08 2.3325512314431 1.87054528568578e-09 MirTarget -1.21428024206699 6.08013000870106e-14 NA NA NA hsa-miR-576-5p BMPR1B 0.0649387707567879 0.588791966096287 2.3325512314431 1.87054528568578e-09 mirMAP -0.437349947086476 9.41645537856705e-05 NA NA NA hsa-miR-889-3p BMPR1B -0.377352927733213 0.00501260024755438 2.3325512314431 1.87054528568578e-09 MirTarget -0.507675391479965 3.5174865160677e-07 NA NA NA hsa-miR-185-5p BMPR2 0.482334746589337 3.68475879959415e-09 -0.619963448559116 4.34614935044474e-16 MirTarget -0.344917833393806 4.84718132418701e-28 NA NA NA hsa-miR-361-5p BMPR2 -0.0996867547900457 0.095428250126326 -0.619963448559116 4.34614935044474e-16 MirTarget;miRanda;mirMAP;miRNATAP -0.334517180577302 6.53819650110874e-14 NA NA NA hsa-let-7d-5p CHRD 0.410958462607207 6.07808182756787e-06 0.643081464361437 0.00226381764531491 MirTarget;miRNATAP -0.76923545518416 3.69579499425558e-23 NA NA NA hsa-let-7g-3p CHRD 0.5854327663695 0.000371711766083627 0.643081464361437 0.00226381764531491 MirTarget -0.386082992677401 2.40311520153789e-19 NA NA NA hsa-let-7g-5p CHRD 0.0200025784917734 0.791635298815256 0.643081464361437 0.00226381764531491 MirTarget;miRNATAP -0.703022574426774 1.56994154115734e-13 NA NA NA hsa-let-7i-5p CHRD -0.333419326258177 3.56960810786801e-08 0.643081464361437 0.00226381764531491 MirTarget;miRNATAP -0.941754610147491 2.05853715388535e-15 NA NA NA hsa-miR-455-3p CHRD 0.678392920628872 0.000327758844555877 0.643081464361437 0.00226381764531491 miRNATAP -0.391985696776891 3.45537050249205e-26 NA NA NA hsa-miR-98-5p CHRD 0.656336869298973 9.03113188590466e-15 0.643081464361437 0.00226381764531491 MirTarget -0.733946495195942 8.35827564110485e-19 NA NA NA hsa-let-7d-5p DCN 0.410958462607207 6.07808182756787e-06 -2.24189494854445 3.67472421736277e-35 MirTarget -0.402955453367597 1.36046683351098e-08 NA NA NA hsa-let-7g-5p DCN 0.0200025784917734 0.791635298815256 -2.24189494854445 3.67472421736277e-35 MirTarget -0.303726193013156 0.000445615748265266 NA NA NA hsa-miR-181b-5p DCN 1.22749257795094 1.21998198830919e-27 -2.24189494854445 3.67472421736277e-35 MirTarget -0.396219797750911 6.579807345297e-13 NA NA NA hsa-miR-181d-5p DCN 0.782618466877349 1.2821116358212e-09 -2.24189494854445 3.67472421736277e-35 MirTarget -0.324337485034118 5.14263997474735e-11 NA NA NA hsa-miR-590-3p DCN 1.27438512890514 1.03164723481469e-23 -2.24189494854445 3.67472421736277e-35 MirTarget;PITA;miRanda;mirMAP -0.52916176505448 1.07716522597725e-25 NA NA NA hsa-miR-7-1-3p DCN 0.686579567507582 1.20731554448806e-07 -2.24189494854445 3.67472421736277e-35 mirMAP -0.417482536233104 1.14965997799617e-17 NA NA NA hsa-miR-98-5p DCN 0.656336869298973 9.03113188590466e-15 -2.24189494854445 3.67472421736277e-35 MirTarget -0.691424742968624 1.12225257396507e-20 NA NA NA hsa-miR-199a-5p E2F5 -0.314703593105081 0.00909304983051124 1.22057233889235 9.21129944070499e-24 miRanda -0.303224745258506 3.21231496741469e-18 NA NA NA hsa-miR-199b-5p E2F5 -1.37022396448377 3.25758057539223e-26 1.22057233889235 9.21129944070499e-24 miRanda -0.336927501630045 2.45223402264681e-27 NA NA NA hsa-miR-590-3p FST 1.27438512890514 1.03164723481469e-23 -0.895876392733032 3.19692454088565e-06 miRanda -0.46419329824237 4.76862887557746e-19 NA NA NA hsa-miR-769-5p FST 0.564871766265874 8.16695101656941e-10 -0.895876392733032 3.19692454088565e-06 MirTarget;miRNATAP -0.577653562671636 2.58108369401135e-16 NA NA NA hsa-miR-342-3p GDF5 1.21944481975657 6.81914373001202e-19 -2.29225103887934 1.9647166261975e-19 miRanda -0.50811169463946 4.33189323314316e-16 NA NA NA hsa-miR-192-5p ID1 1.33366224451777 9.5116159697107e-29 -1.07844448572194 4.92075309042249e-15 miRNAWalker2_validate -0.376309448355852 2.01378377203536e-23 NA NA NA hsa-miR-331-3p ID1 0.74441480542886 1.17071235477799e-07 -1.07844448572194 4.92075309042249e-15 MirTarget -0.386656508179256 2.65685537692846e-32 NA NA NA hsa-miR-192-5p ID4 1.33366224451777 9.5116159697107e-29 -2.95709093256383 7.3098592491371e-46 miRNAWalker2_validate -0.401382751792557 2.84729793814996e-11 NA NA NA hsa-miR-330-5p ID4 0.626063225953928 3.42215028606779e-09 -2.95709093256383 7.3098592491371e-46 miRanda -0.339362600232543 1.52442544121729e-06 NA NA NA hsa-miR-342-3p ID4 1.21944481975657 6.81914373001202e-19 -2.95709093256383 7.3098592491371e-46 MirTarget;PITA;miRanda -0.561987569665707 4.7041735736719e-27 24475217 miR 342 regulates BRCA1 expression through modulation of ID4 in breast cancer; To investigate at functional level the role of miR-342 in the pathogenesis of breast cancer we focused our attention on its "in silico" predicted putative target gene ID4 a transcription factor of the helix-loop-helix protein family whose expression is inversely correlated with that of ER; We functionally validated the interaction between ID4 and miR-342 in a reporter Luciferase system; Based on these findings we hypothesized that regulation of ID4 mediated by miR-342 could be involved in the pathogenesis of breast cancer by downregulating BRCA1 expression; Overexpression of miR-342 in these cells reduced ID4 and increased BRCA1 expression supporting a possible role of this mechanism in breast cancer; In the ER-positive MCF7 and in the BRCA1-mutant HCC1937 cell lines miR-342 over-expression only reduced ID4 breast cancer hsa-miR-629-3p ID4 1.25035919247365 3.91361135469024e-14 -2.95709093256383 7.3098592491371e-46 MirTarget -0.375561354103374 2.07412660127111e-16 NA NA NA hsa-miR-125a-5p IFNG -0.635694700253268 3.6703235721638e-11 0.469173337259002 0.065979531036782 miRanda -0.633234290202444 1.34334735769906e-12 NA NA NA hsa-miR-10b-5p INHBA -2.10996264627796 7.36811595736367e-72 2.92269165168259 7.0734436456195e-54 miRNAWalker2_validate -0.315991143995102 3.56059166646068e-09 NA NA NA hsa-miR-126-5p INHBA -1.27745588751177 2.96000918537631e-30 2.92269165168259 7.0734436456195e-54 mirMAP -0.365446042383557 8.00635434475456e-10 NA NA NA hsa-miR-195-3p INHBA -1.49582726452416 6.53261924105147e-40 2.92269165168259 7.0734436456195e-54 mirMAP -0.457507775640633 2.0024779119854e-15 NA NA NA hsa-miR-26a-5p INHBA -0.481180084102235 1.82368246174758e-10 2.92269165168259 7.0734436456195e-54 mirMAP -0.806583685372971 2.83412051156283e-19 NA NA NA hsa-miR-26b-5p INHBA -0.331527896896866 0.000551258576575092 2.92269165168259 7.0734436456195e-54 mirMAP -0.386714706799185 7.94265255522648e-08 NA NA NA hsa-miR-30a-5p INHBA -0.392489994825279 0.00954894667761676 2.92269165168259 7.0734436456195e-54 mirMAP -0.339337086240446 5.62802453652228e-14 NA NA NA hsa-miR-30b-5p INHBA -0.46540603860146 2.4709940429591e-05 2.92269165168259 7.0734436456195e-54 mirMAP -0.488363240944963 2.76553416939545e-15 NA NA NA hsa-miR-30c-5p INHBA -0.393222674580066 8.06961465717306e-05 2.92269165168259 7.0734436456195e-54 mirMAP -0.554034099183663 5.80415262756076e-16 NA NA NA hsa-miR-30d-5p INHBA -0.247082219011045 0.00406717930063148 2.92269165168259 7.0734436456195e-54 mirMAP -0.560261794318746 2.73850414996811e-12 NA NA NA hsa-miR-335-3p INHBA -1.88448538773649 2.09538234398335e-32 2.92269165168259 7.0734436456195e-54 mirMAP -0.358331308407745 2.90058922815416e-18 NA NA NA hsa-miR-374a-5p INHBA -0.239709888246804 0.00309819667153627 2.92269165168259 7.0734436456195e-54 mirMAP -0.501460291948885 4.49896836409766e-09 NA NA NA hsa-miR-374b-5p INHBA -0.466781429946153 1.17238311619116e-08 2.92269165168259 7.0734436456195e-54 mirMAP -0.423669398924089 4.99022706092223e-07 NA NA NA hsa-miR-664a-3p INHBA -0.237699857923843 0.0197071390183375 2.92269165168259 7.0734436456195e-54 mirMAP -0.329267118225509 1.28384451198929e-06 NA NA NA hsa-let-7a-3p INHBB 0.466622567891891 3.70886257943079e-07 -1.41026732865016 4.33672138785341e-19 mirMAP -0.331545721479258 3.04305684692188e-08 NA NA NA hsa-miR-130b-3p INHBB 1.38122163823846 1.00932179737836e-26 -1.41026732865016 4.33672138785341e-19 miRNATAP -0.381630575170115 9.92225932758929e-21 NA NA NA hsa-miR-130b-5p INHBB 1.0573161199584 2.55177349228739e-12 -1.41026732865016 4.33672138785341e-19 mirMAP -0.308775024147184 3.2108494433814e-18 NA NA NA hsa-miR-454-3p INHBB 1.28177672191095 6.84024979484587e-21 -1.41026732865016 4.33672138785341e-19 miRNATAP -0.300070731677732 2.01102414021318e-14 NA NA NA hsa-miR-590-3p INHBB 1.27438512890514 1.03164723481469e-23 -1.41026732865016 4.33672138785341e-19 miRanda -0.374892224098306 7.33051194100577e-18 NA NA NA hsa-miR-590-5p INHBB 0.746515607868274 8.51300479640125e-09 -1.41026732865016 4.33672138785341e-19 miRanda -0.316300899501723 3.91367503989617e-14 NA NA NA hsa-miR-192-5p LEFTY2 1.33366224451777 9.5116159697107e-29 -2.24240742544647 7.36401202055137e-15 MirTarget -0.638420889641026 1.25196068350713e-15 NA NA NA hsa-miR-339-5p LEFTY2 -0.211548290465418 0.0685885445822389 -2.24240742544647 7.36401202055137e-15 miRanda -0.377171635832493 1.29129734779697e-05 NA NA NA hsa-miR-625-5p LEFTY2 0.728939236913178 5.97591217674307e-08 -2.24240742544647 7.36401202055137e-15 MirTarget -0.588222186492936 6.68599338061733e-15 NA NA NA hsa-miR-148b-3p NOG 1.0552576751879 1.6679285705231e-29 -0.838623753380888 3.81907058171582e-05 MirTarget -0.582391985124335 3.41820665130688e-16 NA NA NA hsa-miR-200c-3p NOG 2.07038651806183 6.84613386286599e-51 -0.838623753380888 3.81907058171582e-05 MirTarget;miRNATAP -0.347080893351845 1.63065263678635e-13 NA NA NA hsa-miR-30d-3p PITX2 0.264544633563642 0.00755023189129747 -0.446534217465074 0.0204393455572554 miRNATAP -0.332002742964576 6.35544311038629e-07 NA NA NA hsa-miR-342-3p PITX2 1.21944481975657 6.81914373001202e-19 -0.446534217465074 0.0204393455572554 miRanda -0.307217323830506 4.38245157775331e-11 NA NA NA hsa-miR-340-5p ROCK2 1.0857159627596 4.94471062546756e-24 -1.42053003829191 2.83260805693116e-25 mirMAP -0.395127263389571 3.35868529258436e-20 NA NA NA hsa-miR-361-5p RPS6KB1 -0.0996867547900457 0.095428250126326 -0.0571936206706596 0.498093695192352 miRanda -0.315724779040643 8.68560752083352e-11 NA NA NA hsa-let-7a-3p SMAD9 0.466622567891891 3.70886257943079e-07 -2.31742580561337 5.2619763732892e-36 mirMAP -0.339440208972422 2.31797137796656e-06 NA NA NA hsa-miR-106b-5p SMAD9 1.22477789913175 2.31787213143326e-32 -2.31742580561337 5.2619763732892e-36 miRNAWalker2_validate;mirMAP -0.491436185819539 6.42844511485369e-16 NA NA NA hsa-miR-200b-3p SMAD9 2.11744072703209 1.66710572104191e-43 -2.31742580561337 5.2619763732892e-36 TargetScan -0.433450642046697 1.02300809234532e-27 NA NA NA hsa-miR-429 SMAD9 2.84108892259147 3.88520896426515e-64 -2.31742580561337 5.2619763732892e-36 miRanda;miRNATAP -0.411129629446905 2.43654737649883e-31 NA NA NA hsa-miR-590-3p SMAD9 1.27438512890514 1.03164723481469e-23 -2.31742580561337 5.2619763732892e-36 mirMAP -0.314485431663451 2.47706353518049e-09 NA NA NA hsa-miR-93-5p SMAD9 1.01788600209314 1.24312921618126e-21 -2.31742580561337 5.2619763732892e-36 mirMAP -0.539678071552204 1.29330103067119e-19 NA NA NA hsa-miR-107 TGFB2 0.678998026350662 2.56224148930538e-16 -0.568239705690126 0.00206510120463672 miRanda -0.401875565283925 8.76701815465238e-08 NA NA NA hsa-miR-148b-3p TGFB2 1.0552576751879 1.6679285705231e-29 -0.568239705690126 0.00206510120463672 MirTarget -0.422618628558287 7.82755899138552e-11 NA NA NA hsa-miR-193a-3p TGFB2 0.310617999804917 0.00477640270974957 -0.568239705690126 0.00206510120463672 MirTarget;miRanda;miRNATAP -0.385790006047712 1.31529188795393e-11 NA NA NA hsa-miR-29b-3p TGFB2 0.438847962603729 6.46722433236121e-05 -0.568239705690126 0.00206510120463672 miRTarBase;MirTarget;miRNATAP -0.435812547346718 1.64777033866721e-14 NA NA NA hsa-miR-29c-3p TGFB2 -0.0652732378039769 0.563774115756922 -0.568239705690126 0.00206510120463672 MirTarget;miRNATAP -0.393270636676739 1.42982951467692e-12 NA NA NA hsa-miR-151a-5p TGFB3 0.509210376738198 3.17540030607215e-07 0.82398957056453 1.83180841509129e-11 MirTarget -0.460270915838936 5.41462985077644e-29 NA NA NA hsa-miR-29b-3p TGFB3 0.438847962603729 6.46722433236121e-05 0.82398957056453 1.83180841509129e-11 miRTarBase -0.300724044682202 2.93536952356929e-15 NA NA NA hsa-miR-361-5p TGFBR1 -0.0996867547900457 0.095428250126326 -0.276773756857041 0.00374479166499862 miRanda;mirMAP;miRNATAP -0.343826208469508 4.82441885336511e-10 NA NA NA hsa-miR-106b-5p TGFBR2 1.22477789913175 2.31787213143326e-32 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.583213497349775 2.44964235169299e-45 NA NA NA hsa-miR-107 TGFBR2 0.678998026350662 2.56224148930538e-16 -2.39529308737339 4.9899056025782e-85 miRanda;miRNATAP -0.530917906321599 1.66581882091816e-22 NA NA NA hsa-miR-130b-3p TGFBR2 1.38122163823846 1.00932179737836e-26 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRNATAP -0.355697993280506 3.73635681408915e-25 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC lung squamous cell cancer hsa-miR-17-5p TGFBR2 0.599531757298529 1.07318660415906e-05 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.344837157501155 3.26279419912174e-25 25011053;27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer ; kidney renal cell cancer;gastric cancer hsa-miR-20a-5p TGFBR2 0.44979911120222 0.000602386964327228 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRTarBase;miRNATAP -0.346418250547717 1.79003902635661e-23 NA NA NA hsa-miR-21-5p TGFBR2 2.32007501846389 3.08394781855554e-137 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRTarBase;miRNATAP -0.537594809270263 3.47307989185754e-40 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway prostate cancer hsa-miR-301a-3p TGFBR2 1.32170168375632 2.12280368957514e-15 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.317266296975964 1.73201531962553e-32 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2 colorectal cancer hsa-miR-340-5p TGFBR2 1.0857159627596 4.94471062546756e-24 -2.39529308737339 4.9899056025782e-85 mirMAP -0.314168975517319 6.41119882395371e-14 NA NA NA hsa-miR-429 TGFBR2 2.84108892259147 3.88520896426515e-64 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.404995702801572 1.14853648012577e-64 NA NA NA hsa-miR-454-3p TGFBR2 1.28177672191095 6.84024979484587e-21 -2.39529308737339 4.9899056025782e-85 miRNATAP -0.384614615164931 1.36686238358356e-32 NA NA NA hsa-miR-590-3p TGFBR2 1.27438512890514 1.03164723481469e-23 -2.39529308737339 4.9899056025782e-85 miRanda -0.338025545666787 3.04278770804611e-20 NA NA NA hsa-miR-93-5p TGFBR2 1.01788600209314 1.24312921618126e-21 -2.39529308737339 4.9899056025782e-85 miRNAWalker2_validate;miRNATAP -0.609999323446729 8.30075605455623e-52 NA NA NA hsa-miR-20a-5p THBS1 0.44979911120222 0.000602386964327228 -0.0614785645873859 0.62138763262321 miRNAWalker2_validate -0.30952947364433 1.36418642869234e-22 NA NA NA hsa-miR-106b-5p THBS2 1.22477789913175 2.31787213143326e-32 0.769808163205687 9.78636441866493e-07 MirTarget -0.302711566656831 1.58196287774772e-09 NA NA NA hsa-miR-20a-5p THBS2 0.44979911120222 0.000602386964327228 0.769808163205687 9.78636441866493e-07 MirTarget -0.342590656166951 2.95705202030977e-17 NA NA NA hsa-miR-29a-3p THBS2 -0.699539666833076 1.13935003139957e-13 0.769808163205687 9.78636441866493e-07 MirTarget -0.330180674500405 5.19990176669046e-09 NA NA NA hsa-miR-29b-3p THBS2 0.438847962603729 6.46722433236121e-05 0.769808163205687 9.78636441866493e-07 MirTarget -0.440296132980001 7.26973369809758e-20 NA NA NA hsa-miR-29c-3p THBS2 -0.0652732378039769 0.563774115756922 0.769808163205687 9.78636441866493e-07 MirTarget -0.431990941588527 4.39914608500664e-20 NA NA NA hsa-miR-320b THBS4 0.412787504747938 0.00113457276903985 -0.661382745748392 0.00786792397096919 miRanda -0.430826287964397 1.28903705137441e-10 NA NA NA hsa-miR-361-5p ZFYVE16 -0.0996867547900457 0.095428250126326 -0.157478145693941 0.0333863072680704 miRanda -0.326076241829422 1.66812492825897e-14 NA NA NA