miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-34a-3p ABL2 1.75590866103657 8.02801510630657e-09 -0.318835189302919 0.0455399452105181 mirMAP -0.110793958648438 5.76064179434403e-05 NA NA NA hsa-miR-34a-3p ACSL4 1.75590866103657 8.02801510630657e-09 -0.411111056706694 0.0792024620124044 MirTarget -0.100279078065506 0.0138763697730261 NA NA NA hsa-miR-34a-3p ADAM12 1.75590866103657 8.02801510630657e-09 0.880573728493143 0.0562283395124088 mirMAP -0.371641777954077 3.06447898212028e-06 NA NA NA hsa-miR-34a-3p ADAMTS15 1.75590866103657 8.02801510630657e-09 -2.81260327679564 2.75117079085055e-06 mirMAP -0.603241141669557 6.61684504092086e-09 NA NA NA hsa-miR-34a-3p AK1 1.75590866103657 8.02801510630657e-09 -0.397160276530387 0.109139593542107 mirMAP -0.165218272224916 0.000118016899369839 NA NA NA hsa-miR-34a-3p ANGPTL1 1.75590866103657 8.02801510630657e-09 -4.51343158742721 1.32318310475559e-13 MirTarget -0.834738590738088 3.32547550227994e-15 NA NA NA hsa-miR-34a-3p ANK2 1.75590866103657 8.02801510630657e-09 -4.31721795702785 2.30783903904989e-14 MirTarget -0.722420944666847 2.96410140236843e-13 NA NA NA hsa-miR-34a-3p ANTXR2 1.75590866103657 8.02801510630657e-09 -2.30617470732809 4.54834840057871e-13 MirTarget -0.556825639449894 4.78736109121951e-25 NA NA NA hsa-miR-34a-3p AQP1 1.75590866103657 8.02801510630657e-09 -2.67772113906004 1.72544569303034e-20 mirMAP -0.311479678566907 1.83152510605737e-09 NA NA NA hsa-miR-34a-3p ATP10D 1.75590866103657 8.02801510630657e-09 -0.688708018852498 0.010040565207979 MirTarget -0.198506709823751 1.83118389094685e-05 NA NA NA hsa-miR-34a-3p C14orf37 1.75590866103657 8.02801510630657e-09 -0.901956851111116 0.0106562989366356 mirMAP -0.313873380020423 2.55287414541775e-07 NA NA NA hsa-miR-34a-3p C17orf51 1.75590866103657 8.02801510630657e-09 -0.678914258700408 0.0225411911064938 mirMAP -0.131335734357093 0.0113538421531572 NA NA NA hsa-miR-34a-3p C1orf21 1.75590866103657 8.02801510630657e-09 -1.50529673423141 7.359521051655e-11 mirMAP -0.223283835169312 3.72859756984491e-08 NA NA NA hsa-miR-34a-3p CALCRL 1.75590866103657 8.02801510630657e-09 -0.674062360195245 0.0153660762525996 MirTarget -0.174695996925756 0.000298165319963101 NA NA NA hsa-miR-34a-3p CAMK2A 1.75590866103657 8.02801510630657e-09 -4.13920739991396 5.06813084231462e-14 mirMAP -0.705996788293823 2.02378001337888e-13 NA NA NA hsa-miR-34a-3p CBX6 1.75590866103657 8.02801510630657e-09 -1.53953176885359 2.83932741324751e-07 mirMAP -0.107609598955196 0.042312163859237 NA NA NA hsa-miR-34a-3p CD84 1.75590866103657 8.02801510630657e-09 -0.533438552489043 0.279469755133035 mirMAP -0.410902340173266 1.3259726653445e-06 NA NA NA hsa-miR-34a-3p CDK6 1.75590866103657 8.02801510630657e-09 -0.774202349805119 0.064787030605636 mirMAP -0.376950684687892 1.73963312821001e-07 21702042;26104764 Molecular analyses identified Cdk6 and sirtuin SIRT-1 as being targeted by miR-34a in MI-TCC cells however inhibition of Cdk6 and SIRT-1 was not as effective as pre-miR-34a in mediating chemosensitization;The expression of microRNA 34a is inversely correlated with c MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients; We found significant inverse correlations between miR-34a and c-MET R = -0.316 P = 0.028 and CDK6 expression R = -0.4582 P = 0.004 ; bladder cancer;lung cancer hsa-miR-34a-3p CIITA 1.75590866103657 8.02801510630657e-09 -0.0228897168841891 0.959678389546489 mirMAP -0.249696304864249 0.00147861241410502 NA NA NA hsa-miR-34a-3p CLEC5A 1.75590866103657 8.02801510630657e-09 2.07254334943587 6.0252743848656e-06 mirMAP -0.172041421066825 0.0329830131337464 NA NA NA hsa-miR-34a-3p CPS1 1.75590866103657 8.02801510630657e-09 -1.11652021429305 0.0405146715554937 MirTarget -0.262684893117082 0.00566412255698762 NA NA NA hsa-miR-34a-3p CSRP1 1.75590866103657 8.02801510630657e-09 -2.62326143816756 3.70435577936935e-25 MirTarget -0.418210829669929 7.26500110904056e-21 NA NA NA hsa-miR-34a-3p CYP26B1 1.75590866103657 8.02801510630657e-09 -0.687056430058883 0.15191405383577 mirMAP -0.333829300988881 5.77023493413644e-05 NA NA NA hsa-miR-34a-3p CYTIP 1.75590866103657 8.02801510630657e-09 -1.07497665587783 0.0127239450608286 MirTarget -0.367204108978533 8.28040788105298e-07 NA NA NA hsa-miR-34a-3p DENND5A 1.75590866103657 8.02801510630657e-09 -1.18678560113232 3.24357450546046e-11 MirTarget -0.207787824026498 2.49520737413423e-11 NA NA NA hsa-miR-34a-3p DOK6 1.75590866103657 8.02801510630657e-09 -3.80154682978045 3.47096997618837e-18 mirMAP -0.575452532609143 8.92492726881891e-14 NA NA NA hsa-miR-34a-3p DPYSL2 1.75590866103657 8.02801510630657e-09 -1.76435544537318 3.16983700434577e-10 MirTarget -0.346879067212368 9.45441179829327e-13 NA NA NA hsa-miR-34a-3p DRP2 1.75590866103657 8.02801510630657e-09 -1.34779224755633 0.000228883511200255 mirMAP -0.286281226097119 6.69085119414981e-06 NA NA NA hsa-miR-34a-3p DST 1.75590866103657 8.02801510630657e-09 -1.11542714896545 9.14769438027749e-05 mirMAP -0.151845585320507 0.00234549283857459 NA NA NA hsa-miR-34a-3p DUSP1 1.75590866103657 8.02801510630657e-09 -3.47418646928724 1.98436002754553e-20 MirTarget -0.384933267542239 1.17086840216167e-08 NA NA NA hsa-miR-34a-3p ETS1 1.75590866103657 8.02801510630657e-09 -0.699528618233348 0.00228038287696191 MirTarget -0.130153884614291 0.00111725955210861 NA NA NA hsa-miR-34a-3p FMNL3 1.75590866103657 8.02801510630657e-09 0.138843294816209 0.460998322398368 mirMAP -0.102447251323809 0.00168714910918359 NA NA NA hsa-miR-34a-3p FOXP2 1.75590866103657 8.02801510630657e-09 -3.99353205302265 7.58170962329672e-11 MirTarget -0.619952409527237 8.53624703497391e-09 NA NA NA hsa-miR-34a-3p FTO 1.75590866103657 8.02801510630657e-09 -0.521763496896368 9.56066637934397e-05 mirMAP -0.131386020761889 1.11199678775658e-08 NA NA NA hsa-miR-34a-3p GFOD1 1.75590866103657 8.02801510630657e-09 -0.940659645129877 0.00660758228917747 mirMAP -0.310154654691425 2.07905765618741e-07 NA NA NA hsa-miR-34a-3p GRIN2A 1.75590866103657 8.02801510630657e-09 -3.3233994538381 1.07825857067501e-08 mirMAP -0.497080909536274 1.09354087082569e-06 NA NA NA hsa-miR-34a-3p HUNK 1.75590866103657 8.02801510630657e-09 -2.26986927474702 1.0712218399358e-05 mirMAP -0.342102533529709 0.000150619093330449 NA NA NA hsa-miR-34a-3p JAZF1 1.75590866103657 8.02801510630657e-09 -1.91995536790338 5.72076669427973e-12 MirTarget -0.404238666633075 3.50503557637189e-17 NA NA NA hsa-miR-34a-3p JUN 1.75590866103657 8.02801510630657e-09 -2.04611084807692 9.1524625995215e-13 MirTarget -0.279858707540387 3.1061995990995e-08 NA NA NA hsa-miR-34a-3p KCNIP3 1.75590866103657 8.02801510630657e-09 -1.80534164990204 1.72863272403937e-06 mirMAP -0.314254514062884 1.83420285960016e-06 NA NA NA hsa-miR-34a-3p KCNJ12 1.75590866103657 8.02801510630657e-09 -2.26039929904991 2.90659346174232e-05 mirMAP -0.473639041692866 4.60272237586112e-07 NA NA NA hsa-miR-34a-3p KIAA1614 1.75590866103657 8.02801510630657e-09 -2.0146471536211 8.95131044809253e-13 mirMAP -0.334313108138439 1.2102956112082e-11 NA NA NA hsa-miR-34a-3p KIAA1644 1.75590866103657 8.02801510630657e-09 -4.40439862301283 1.42085780669109e-16 mirMAP -0.842213569139149 6.69088486807237e-20 NA NA NA hsa-miR-34a-3p KLF13 1.75590866103657 8.02801510630657e-09 -1.16141618366409 1.36372480238947e-05 mirMAP -0.222285302303594 1.71040682804869e-06 NA NA NA hsa-miR-34a-3p LONRF2 1.75590866103657 8.02801510630657e-09 -3.8642101573018 7.90463940348435e-08 mirMAP -0.298242319111488 0.019208027727651 NA NA NA hsa-miR-34a-3p LRRC4 1.75590866103657 8.02801510630657e-09 -1.72814927293197 4.11405671443744e-06 MirTarget -0.238277256407817 0.000292461194665914 NA NA NA hsa-miR-34a-3p MAOB 1.75590866103657 8.02801510630657e-09 -4.31944111599063 3.90207430592244e-13 MirTarget -0.859140682167966 6.58785674498745e-17 NA NA NA hsa-miR-34a-3p MAP3K2 1.75590866103657 8.02801510630657e-09 -0.461416176318694 0.0183069160365383 mirMAP -0.125323236814494 0.000218844943648558 NA NA NA hsa-miR-34a-3p MEF2D 1.75590866103657 8.02801510630657e-09 -1.254473345286 3.30937184393369e-26 MirTarget -0.133214305210976 5.28856855936635e-10 NA NA NA hsa-miR-34a-3p MITF 1.75590866103657 8.02801510630657e-09 -2.11043666647908 2.14681139044162e-09 MirTarget -0.438901834940701 5.90896046706837e-13 NA NA NA hsa-miR-34a-3p MN1 1.75590866103657 8.02801510630657e-09 -2.44287385467581 8.2364144685939e-08 mirMAP -0.557387232821182 1.25500737070242e-12 NA NA NA hsa-miR-34a-3p MRC1 1.75590866103657 8.02801510630657e-09 -1.55339064711366 0.00169894007697091 MirTarget -0.449857761682576 1.42434647129744e-07 NA NA NA hsa-miR-34a-3p MYO9A 1.75590866103657 8.02801510630657e-09 -1.29622192336459 1.1786138431555e-06 mirMAP -0.18875708670705 5.33783336628656e-05 NA NA NA hsa-miR-34a-3p NFATC2 1.75590866103657 8.02801510630657e-09 -2.09940213646525 2.77134949511158e-05 mirMAP -0.301138281046132 0.000597201447878319 NA NA NA hsa-miR-34a-3p NMT2 1.75590866103657 8.02801510630657e-09 -1.13970368424634 2.22188932113873e-05 MirTarget -0.279436422642285 1.66361824118756e-09 NA NA NA hsa-miR-34a-3p NTRK2 1.75590866103657 8.02801510630657e-09 -3.4444884279512 9.02401971614574e-08 mirMAP -0.545493213319934 1.33340706209908e-06 NA NA NA hsa-miR-34a-3p NTRK3 1.75590866103657 8.02801510630657e-09 -5.17034960965042 5.23662623079398e-21 mirMAP -0.410313404824883 4.09349897404522e-05 NA NA NA hsa-miR-34a-3p OSBPL10 1.75590866103657 8.02801510630657e-09 -1.83322990423673 6.62607328092423e-12 mirMAP -0.324819359376941 2.90002957911466e-12 NA NA NA hsa-miR-34a-3p PALLD 1.75590866103657 8.02801510630657e-09 -2.68837995750497 4.71973205022663e-15 MirTarget -0.584792638114991 1.76021754761601e-23 NA NA NA hsa-miR-34a-3p PALM2 1.75590866103657 8.02801510630657e-09 0.556813445440219 0.127115395747529 mirMAP -0.143018866632419 0.024494994700974 NA NA NA hsa-miR-34a-3p PCDH17 1.75590866103657 8.02801510630657e-09 -0.31543828817169 0.277167062556602 MirTarget -0.11839717380768 0.0190554854524598 NA NA NA hsa-miR-34a-3p PLXDC1 1.75590866103657 8.02801510630657e-09 0.00175712757885371 0.994886591921339 mirMAP -0.172713387848088 0.000272231938531618 NA NA NA hsa-miR-34a-3p PLXDC2 1.75590866103657 8.02801510630657e-09 -1.34047302912636 0.000646552650747008 MirTarget -0.440288838909503 6.18620129417862e-11 NA NA NA hsa-miR-34a-3p PPARA 1.75590866103657 8.02801510630657e-09 -0.909556027391561 1.42525593811011e-05 mirMAP -0.112427386079004 0.00220301992910965 NA NA NA hsa-miR-34a-3p PPP1R16B 1.75590866103657 8.02801510630657e-09 -1.51043585925807 2.23466511532997e-06 mirMAP -0.243665262217269 1.26327139116093e-05 NA NA NA hsa-miR-34a-3p PTGS2 1.75590866103657 8.02801510630657e-09 -2.90239684568393 1.42525690641941e-08 MirTarget -0.269119883838932 0.00296530834428862 23349340 Furthermore restoration of miR-34a indirectly reduced cyclooxygenase-2 COX-2 expression lung squamous cell cancer hsa-miR-34a-3p PTPRD 1.75590866103657 8.02801510630657e-09 -3.62979486144354 1.88740064210481e-09 mirMAP -0.582135918803785 3.7854215211262e-08 NA NA NA hsa-miR-34a-3p QKI 1.75590866103657 8.02801510630657e-09 -0.459712923996318 0.00440824124371165 mirMAP -0.109120404469189 9.60476243235872e-05 NA NA NA hsa-miR-34a-3p RASGRF2 1.75590866103657 8.02801510630657e-09 -0.959101466033611 0.00295453490406439 mirMAP -0.243930495689873 1.30413895856795e-05 NA NA NA hsa-miR-34a-3p RGP1 1.75590866103657 8.02801510630657e-09 -0.559845500700471 0.0212137137112516 mirMAP -0.134302188796558 0.0014756128211089 NA NA NA hsa-miR-34a-3p RIC3 1.75590866103657 8.02801510630657e-09 -3.43247685741947 4.37531147104872e-10 mirMAP -0.38556194587448 7.45140341916226e-05 NA NA NA hsa-miR-34a-3p RIMBP2 1.75590866103657 8.02801510630657e-09 -2.69405047193145 5.63343241147361e-07 mirMAP -0.482049955483089 2.85096857700764e-07 NA NA NA hsa-miR-34a-3p RNF212 1.75590866103657 8.02801510630657e-09 -2.78983710949886 1.11878098033565e-08 MirTarget -0.431292829267277 4.71024046836822e-07 NA NA NA hsa-miR-34a-3p RORA 1.75590866103657 8.02801510630657e-09 -1.82057461685128 1.16708465709096e-09 mirMAP -0.256679101394341 1.05899002065178e-06 NA NA NA hsa-miR-34a-3p RUNX1T1 1.75590866103657 8.02801510630657e-09 -3.29112409449622 2.69681218718585e-11 mirMAP -0.595073964254965 4.64645365708717e-12 NA NA NA hsa-miR-34a-3p RYR2 1.75590866103657 8.02801510630657e-09 -3.05265921395896 1.45778696980797e-09 MirTarget -0.533373422858687 1.39670010514712e-09 NA NA NA hsa-miR-34a-3p SCN4B 1.75590866103657 8.02801510630657e-09 -2.75295017691825 5.60438848890772e-15 mirMAP -0.236263425753356 0.000184832597599464 NA NA NA hsa-miR-34a-3p SCUBE3 1.75590866103657 8.02801510630657e-09 -2.48127471582544 2.66234551923326e-07 mirMAP -0.355693853456019 2.61379677537517e-05 NA NA NA hsa-miR-34a-3p SEC14L5 1.75590866103657 8.02801510630657e-09 -1.9585056768621 1.373499911545e-06 mirMAP -0.202928868347395 0.00449052273863959 NA NA NA hsa-miR-34a-3p SEMA3G 1.75590866103657 8.02801510630657e-09 -2.05508087978353 1.36277460835523e-11 mirMAP -0.147347198074779 0.00657549257881321 NA NA NA hsa-miR-34a-3p SH3PXD2A 1.75590866103657 8.02801510630657e-09 -0.987155493438988 1.02406192375196e-05 mirMAP -0.120433847851291 0.00214039581069697 NA NA NA hsa-miR-34a-3p SIGLEC1 1.75590866103657 8.02801510630657e-09 -0.883561500953726 0.0567098450341222 mirMAP -0.336393092953058 2.77747683678669e-05 NA NA NA hsa-miR-34a-3p SIRPA 1.75590866103657 8.02801510630657e-09 -0.55339733363088 0.119266182012343 mirMAP -0.290503301315426 2.1088876850994e-06 NA NA NA hsa-miR-34a-3p SLC1A2 1.75590866103657 8.02801510630657e-09 -1.63926856184029 0.00011983867188635 mirMAP -0.176580479660607 0.0182126777346772 NA NA NA hsa-miR-34a-3p SORBS3 1.75590866103657 8.02801510630657e-09 -0.911770774821273 0.000206893188339556 mirMAP -0.166394087119574 0.000101538745434058 NA NA NA hsa-miR-34a-3p SSFA2 1.75590866103657 8.02801510630657e-09 -0.51178832437508 0.043734278908624 MirTarget -0.133240751268309 0.0025278069529706 NA NA NA hsa-miR-34a-3p SULF1 1.75590866103657 8.02801510630657e-09 0.171691676108908 0.757613998121678 mirMAP -0.498412610170346 1.83797149094107e-07 NA NA NA hsa-miR-34a-3p SV2B 1.75590866103657 8.02801510630657e-09 -2.33341367960543 7.07116491599061e-05 mirMAP -0.597999694543761 3.64082141572019e-09 NA NA NA hsa-miR-34a-3p SYT11 1.75590866103657 8.02801510630657e-09 -2.11616848018482 5.62916826382274e-11 MirTarget -0.409455816797129 2.60606606120483e-13 NA NA NA hsa-miR-34a-3p TEAD1 1.75590866103657 8.02801510630657e-09 -1.49495998391161 1.96516757915294e-13 mirMAP -0.20122072275574 2.0870412367237e-08 NA NA NA hsa-miR-34a-3p TGFBRAP1 1.75590866103657 8.02801510630657e-09 -0.0334139934137641 0.90173766480818 MirTarget -0.106613994604374 0.0234667284590669 NA NA NA hsa-miR-34a-3p TMEM108 1.75590866103657 8.02801510630657e-09 -2.78114300571125 1.45650573276381e-06 mirMAP -0.617024525011893 6.55507018933284e-10 NA NA NA hsa-miR-34a-3p TMEM169 1.75590866103657 8.02801510630657e-09 0.212722927647041 0.605338323475114 MirTarget -0.166042163540325 0.0204394480568253 NA NA NA hsa-miR-34a-3p TMEM176B 1.75590866103657 8.02801510630657e-09 -0.972517687411243 0.0153620393583331 MirTarget -0.278115096386223 6.45482456041284e-05 NA NA NA hsa-miR-34a-3p TMEM47 1.75590866103657 8.02801510630657e-09 -1.46523064388337 0.00016547778482874 MirTarget -0.235567398155103 0.000528690945918966 NA NA NA hsa-miR-34a-3p TMOD2 1.75590866103657 8.02801510630657e-09 -1.02377830752032 1.97345844232229e-05 mirMAP -0.221237440614499 1.02753563650461e-07 NA NA NA hsa-miR-34a-3p TRAM2 1.75590866103657 8.02801510630657e-09 -0.480560165227073 0.0151980825679313 MirTarget -0.164222586257323 1.50405024887082e-06 NA NA NA hsa-miR-34a-3p TSPAN18 1.75590866103657 8.02801510630657e-09 -2.63099439180161 1.17021451486886e-12 mirMAP -0.422732031189802 7.23649353648052e-11 NA NA NA hsa-miR-34a-3p UBXN7 1.75590866103657 8.02801510630657e-09 0.00200501422604882 0.992854523204685 mirMAP -0.123717756967824 0.00142484469764508 NA NA NA hsa-miR-34a-3p YAP1 1.75590866103657 8.02801510630657e-09 -0.819514922156015 7.72909626929227e-05 MirTarget -0.169740717437944 2.39565677986146e-06 NA NA NA hsa-miR-34a-3p ZDHHC15 1.75590866103657 8.02801510630657e-09 -2.821890119317 1.80193983474815e-08 MirTarget -0.495473936603327 1.46930762409982e-08 NA NA NA hsa-miR-34a-3p ZEB1 1.75590866103657 8.02801510630657e-09 -2.59416392469398 4.19342616481451e-16 MirTarget -0.465466770273706 5.03734977065572e-17 26359358 Finally an integral role of miR-34a is discovered as miR-34a mimic potentiates HNK-mediated inhibition of EMT Zeb1 expression and nuclear-localization mammosphere-formation and expression of stemness factors breast cancer hsa-miR-34a-3p ZFP37 1.75590866103657 8.02801510630657e-09 -0.810062916275531 0.0701924167642926 MirTarget -0.159571056201601 0.0408833881441877 NA NA NA