miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-183-5p	ABCA1	-1.21596931064487	1.31473205758898e-08	1.47896121247466	5.06182495427067e-34	MirTarget;miRNATAP	-0.105547403560757	0.00192468477755443	26935154	MiR 183 functions as an oncogene by targeting ABCA1 in colon cancer; We found that miR-183 targets the 3'UTR of ABCA1 mRNA; Subsequent experiments confirmed that miR-183 degraded ABCA1 mRNA in the colon cancer cells; Thus we conclude that miR-183 promotes proliferation and inhibits apoptosis by degrading ABCA1 in colon cancer		colon cancer
hsa-miR-183-5p	AJAP1	-1.21596931064487	1.31473205758898e-08	-1.50068943969247	2.04085559170673e-12	MirTarget	-0.13459639349463	0.0158323243123501		NA	NA	NA
hsa-miR-183-5p	ARHGAP26	-1.21596931064487	1.31473205758898e-08	1.01456803455861	4.57506189547863e-25	MirTarget	-0.1701587048789	5.63799767981556e-11		NA	NA	NA
hsa-miR-183-5p	ARHGAP32	-1.21596931064487	1.31473205758898e-08	0.033087683445701	0.682961704919414	miRNAWalker2_validate	-0.144787136877794	1.48881262567724e-13		NA	NA	NA
hsa-miR-183-5p	BCL11B	-1.21596931064487	1.31473205758898e-08	1.57093281316392	4.24198068327851e-22	miRNAWalker2_validate;miRNATAP	-0.142593448397965	0.00110667377069146		NA	NA	NA
hsa-miR-183-5p	BNIP3L	-1.21596931064487	1.31473205758898e-08	0.877748631926591	2.3726316473653e-22	MirTarget;miRNATAP	-0.113789715154326	2.20465445627668e-06		NA	NA	NA
hsa-miR-183-5p	CACNA1E	-1.21596931064487	1.31473205758898e-08	0.398553815240906	0.0688348888728027	miRNATAP	-0.129280887143363	0.0194074350613106		NA	NA	NA
hsa-miR-183-5p	CCDC85C	-1.21596931064487	1.31473205758898e-08	-0.392722228421582	6.44511289916031e-05	mirMAP	-0.129106919827139	1.51657771761807e-07		NA	NA	NA
hsa-miR-183-5p	CCND1	-1.21596931064487	1.31473205758898e-08	2.13480598480786	2.71111034411853e-47	miRNAWalker2_validate	-0.374903452579708	3.93459169450664e-20		NA	NA	NA
hsa-miR-183-5p	CELF6	-1.21596931064487	1.31473205758898e-08	0.747804681640877	8.05571633350397e-05	MirTarget	-0.152554212629786	0.00153674694464039		NA	NA	NA
hsa-miR-183-5p	CLCN6	-1.21596931064487	1.31473205758898e-08	0.175639928295381	0.0226011175508707	mirMAP	-0.142498030081925	2.13540212290061e-14		NA	NA	NA
hsa-miR-183-5p	CTDSP1	-1.21596931064487	1.31473205758898e-08	0.285128586628115	2.60028620194526e-05	miRNATAP	-0.121125775362052	3.10172610279417e-13		NA	NA	NA
hsa-miR-183-5p	CX3CL1	-1.21596931064487	1.31473205758898e-08	0.952424036117255	7.21591339245588e-17	MirTarget	-0.227260448697756	4.6841302075687e-15		NA	NA	NA
hsa-miR-183-5p	CYYR1	-1.21596931064487	1.31473205758898e-08	0.263638621328482	0.0413034561452226	MirTarget	-0.207405962714076	6.01698467783529e-11		NA	NA	NA
hsa-miR-183-5p	DGKE	-1.21596931064487	1.31473205758898e-08	-0.210244388579524	0.0499646837497474	miRNATAP	-0.148467878151665	2.16169103223259e-08		NA	NA	NA
hsa-miR-183-5p	EMP2	-1.21596931064487	1.31473205758898e-08	0.115211583617879	0.242338249302683	MirTarget	-0.123457421702944	4.27742004525275e-07		NA	NA	NA
hsa-miR-183-5p	EPHA4	-1.21596931064487	1.31473205758898e-08	-0.750054555076015	5.63577738300705e-07	miRNATAP	-0.22560312771859	1.92071439477517e-09		NA	NA	NA
hsa-miR-183-5p	EZR	-1.21596931064487	1.31473205758898e-08	0.232925138891575	0.00917537400498294	miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP	-0.127934808520005	7.07435563707191e-09	24352761;22525461;22851079;21176563;25337200;22922800;18840437;20858276	MicroRNA-183 miR-183 has been demonstrated to be a tumor suppressor miRNA in inhibition of migration and invasion of osteosarcoma by targeting an oncogene Ezrin; The aim of the present study was to determine the correlation of combined miR-183 and Ezrin mRNA expression with clinicopathologic features and prognosis in patients with osteosarcomas; Expressions of MiR-183 and Ezrin mRNA were both examined using quantitative real-time reverse transcriptase-polymerase chain reaction analysis in 68 specimens from patients with osteosarcomas; MiR-183 and Ezrin mRNA expression levels were respectively lower and higher in osteosarcoma tissues than those in noncancerous bone tissues significantly both P < 0.001; Notably the downregulation of miR-183 was negatively correlated with the upregulation of Ezrin mRNA in osteosarcoma tissues r = -0.66 P = 0.01; In addition the combined miR-183 downregulation and Ezrin upregulation miR-183-low/Ezrin-high was significantly associated with high tumor grade P = 0.02 poor response to chemotherapy P = 0.01 positive metastasis P = 0.006 and recurrence P = 0.008; Our findings showed that the aberrant expression of miR-183 and its target gene Ezrin may play a crucial role in the development and progression of human osteosarcoma;Down regulation of miR 183 promotes migration and invasion of osteosarcoma by targeting Ezrin; Using a luciferase reporter carrying the 3'-untranslated region 3'-UTR of Ezrin we identified Ezrin as a direct target of miR-183; Of interest suppression of Ezrin by miR-183 caused a reduction of phosphorylated p44/42 p-p44/42; Finally suppression of Ezrin by RNAi mimicked miR-183 action in the suppression of migration and invasion which was associated with down-regulation of p-p44/42;Expression of microRNA 183 in stage II  gastric cancer and its association with Ezrin protein; To investigate the expression of microRNA-183 miR-183 and Ezrin protein in stage II gastric cancer GC; The associations of miR-183 expression with the clinicopathologic features of stage II GC and Ezrin expression were analyzed; Ezrin is a potential regulatory protein of miR-183;2 By a functional screen using miRNA microarray combined with bioinformatics analysis the miR-183 and miR-22 were indentified as two candidate miRNA which may have the potential regulatory role in ezrin expression; A subsequent validation by western blot and real time RT-PCR revealed that over-expression of miR-183 and miR-22 could both lead to an obvious decrease in ezrin protein level while there were not signicant difference in the level of ezrin mRNA P > 0.05;miR 183 inhibits invasion of gastric cancer by targeting Ezrin; Overexpression of miR-183 markedly suppressed cells invasion by downregulation of Ezrin expression; In conclusion our study demonstrated that miR-183 acts as a tumor suppressor in GC partially at least via regulation of Ezrin;miR 183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells; In our study ectopic overexpression of miR-183 repressed the expression levels of Ezrin and significantly inhibited the motility and invasion of osteosarcoma cells; This suggests that miR-183 may possibly play a tumor suppressor role in the metastasis of osteosarcoma by downregulating Ezrin expression levels; These findings show that through inhibition of Ezrin expression levels miR-183 is significantly involved in cell migration and invasion of osteosarcoma;MicroRNA 183 regulates Ezrin expression in lung cancer cells; Mechanistically we identified VIL2-coding-protein Ezrin as a bona fide target of miR-183;Specifically the VIL2-coding protein Ezrin was confirmed as a target of miR-183 and downregulation of this protein was confirmed with immunocytochemistry; These findings indicate that miR-183 targets VIL2 and may play a central role in the regulation of migration and metastasis in breast cancer	worse prognosis;metastasis;recurrence;drug resistance;progression;;staging;;;metastasis;motility;cell migration;;metastasis	sarcoma;sarcoma;gastric cancer;ovarian cancer;gastric cancer;sarcoma;lung cancer;breast cancer
hsa-miR-183-5p	FRMD6	-1.21596931064487	1.31473205758898e-08	0.2039129802354	0.0629210786657724	MirTarget;miRNATAP	-0.105015821040555	0.000130623051159275		NA	NA	NA
hsa-miR-183-5p	GYPA	-1.21596931064487	1.31473205758898e-08	-0.868309476810337	0.0127856947399886	MirTarget	-0.381100176888278	1.28668031729931e-05		NA	NA	NA
hsa-miR-183-5p	HLA-A	-1.21596931064487	1.31473205758898e-08	1.72471607536277	1.62848377184263e-59	miRNAWalker2_validate	-0.105613117629531	0.00100376645077134		NA	NA	NA
hsa-miR-183-5p	ITGA5	-1.21596931064487	1.31473205758898e-08	2.04116263996683	7.34474138145585e-47	miRNAWalker2_validate	-0.168509641988799	4.28263649045998e-05		NA	NA	NA
hsa-miR-183-5p	ITGA8	-1.21596931064487	1.31473205758898e-08	-1.18440342923207	3.23543026206956e-06	miRNAWalker2_validate	-0.133170720364379	0.0411527525143136		NA	NA	NA
hsa-miR-183-5p	JAM3	-1.21596931064487	1.31473205758898e-08	0.413983531183135	0.000161735813987663	MirTarget	-0.197812138199678	1.87840202800439e-13		NA	NA	NA
hsa-miR-183-5p	KCNMA1	-1.21596931064487	1.31473205758898e-08	2.37795015319896	1.52495426021993e-28	miRNATAP	-0.32316663286636	2.60918286949082e-08		NA	NA	NA
hsa-miR-183-5p	KDELC2	-1.21596931064487	1.31473205758898e-08	0.710197581606902	5.19890023436007e-17	miRNAWalker2_validate	-0.131527137535022	1.99362709313532e-09		NA	NA	NA
hsa-miR-183-5p	KIAA0355	-1.21596931064487	1.31473205758898e-08	0.0442932139205894	0.534339907455475	MirTarget;miRNATAP	-0.116621785626392	1.79939890753826e-11		NA	NA	NA
hsa-miR-183-5p	KIAA1614	-1.21596931064487	1.31473205758898e-08	-0.0796274304090994	0.492758389791727	mirMAP	-0.150628187184983	1.56687599154176e-07		NA	NA	NA
hsa-miR-183-5p	KIF21B	-1.21596931064487	1.31473205758898e-08	2.43718820459287	8.37151744969102e-49	mirMAP	-0.199838072925819	3.70396933545882e-05		NA	NA	NA
hsa-miR-183-5p	KIF5C	-1.21596931064487	1.31473205758898e-08	-0.714927207901975	4.26840048946345e-07	miRNAWalker2_validate;MirTarget	-0.116166755855103	0.0013112571354827		NA	NA	NA
hsa-miR-183-5p	KLHL23	-1.21596931064487	1.31473205758898e-08	0.174226640187491	0.230690449868743	miRNAWalker2_validate;MirTarget	-0.169290228793376	2.8567077245775e-06		NA	NA	NA
hsa-miR-183-5p	KLRD1	-1.21596931064487	1.31473205758898e-08	2.74050528262806	2.83450507151126e-56	MirTarget	-0.230125704975915	8.47075689525519e-06		NA	NA	NA
hsa-miR-183-5p	LENG8	-1.21596931064487	1.31473205758898e-08	1.07626764384975	6.4018553056604e-12	miRNAWalker2_validate	-0.114369753751606	0.00505813410505352		NA	NA	NA
hsa-miR-183-5p	MAP3K13	-1.21596931064487	1.31473205758898e-08	0.209933658790665	0.137301360590936	MirTarget;miRNATAP	-0.100768471482234	0.00458513376341543		NA	NA	NA
hsa-miR-183-5p	MEF2C	-1.21596931064487	1.31473205758898e-08	1.18850699554719	2.40959602606182e-26	MirTarget;miRNATAP	-0.209154679494919	1.60648867035922e-12		NA	NA	NA
hsa-miR-183-5p	MICA	-1.21596931064487	1.31473205758898e-08	0.449705316210591	5.88880715347289e-07	MirTarget	-0.105020416446376	4.02450837845465e-06		NA	NA	NA
hsa-miR-183-5p	NCK2	-1.21596931064487	1.31473205758898e-08	0.742747845033585	8.14161701824638e-28	MirTarget;miRNATAP	-0.102186758464371	2.22868195711212e-08		NA	NA	NA
hsa-miR-183-5p	NHSL2	-1.21596931064487	1.31473205758898e-08	-0.266465707471121	0.0931105137221145	miRNAWalker2_validate	-0.100433843425537	0.0120586719061222		NA	NA	NA
hsa-miR-183-5p	NOVA2	-1.21596931064487	1.31473205758898e-08	1.75131970330841	4.31693555887051e-30	mirMAP	-0.354335094849272	1.62549613305317e-18		NA	NA	NA
hsa-miR-183-5p	NRG1	-1.21596931064487	1.31473205758898e-08	-0.510387568244434	0.00482588663356743	miRNATAP	-0.125693561383713	0.00606338669869557		NA	NA	NA
hsa-miR-183-5p	NRIP2	-1.21596931064487	1.31473205758898e-08	0.342091820294566	0.0109707324907779	MirTarget	-0.191346925369805	9.15084092379076e-09		NA	NA	NA
hsa-miR-183-5p	NRP2	-1.21596931064487	1.31473205758898e-08	1.95898319041997	1.84150291182932e-40	miRNATAP	-0.191066580845296	4.54481137368253e-06		NA	NA	NA
hsa-miR-183-5p	NRXN3	-1.21596931064487	1.31473205758898e-08	0.859072982207994	2.47139430502059e-06	miRNATAP	-0.132911290426721	0.00434985634629827		NA	NA	NA
hsa-miR-183-5p	PAQR9	-1.21596931064487	1.31473205758898e-08	2.88995777114065	1.78006963842491e-25	MirTarget	-0.149919163293792	0.047890719463336		NA	NA	NA
hsa-miR-183-5p	PCDH19	-1.21596931064487	1.31473205758898e-08	-0.812978148938848	5.67134913108149e-07	mirMAP	-0.113889187480495	0.00623645995252722		NA	NA	NA
hsa-miR-183-5p	PLCH2	-1.21596931064487	1.31473205758898e-08	-0.00959400503878305	0.969651918965393	mirMAP	-0.286501691520276	5.01200305438537e-06		NA	NA	NA
hsa-miR-183-5p	PLD1	-1.21596931064487	1.31473205758898e-08	0.455999662224987	6.99859154369231e-06	mirMAP	-0.179895641590124	6.36914820958763e-13		NA	NA	NA
hsa-miR-183-5p	PPM1F	-1.21596931064487	1.31473205758898e-08	0.992473330059062	1.71239168983055e-28	mirMAP	-0.216988176730459	8.57222187844739e-21		NA	NA	NA
hsa-miR-183-5p	PRUNE2	-1.21596931064487	1.31473205758898e-08	1.05218002151134	8.10928029291627e-08	miRNATAP	-0.29896476816968	1.31549100984243e-09		NA	NA	NA
hsa-miR-183-5p	RALGDS	-1.21596931064487	1.31473205758898e-08	1.09793021618138	3.44535423332662e-31	miRNAWalker2_validate;MirTarget;miRNATAP	-0.180331701752858	1.2029085073756e-12		NA	NA	NA
hsa-miR-183-5p	RHOB	-1.21596931064487	1.31473205758898e-08	0.710319193425473	5.78451706449585e-08	miRNATAP	-0.27513581947755	7.92983201440772e-18		NA	NA	NA
hsa-miR-183-5p	RHOBTB1	-1.21596931064487	1.31473205758898e-08	1.06708324605128	1.22299929327761e-13	miRNATAP	-0.14982913173971	6.34400660466222e-05		NA	NA	NA
hsa-miR-183-5p	RORA	-1.21596931064487	1.31473205758898e-08	0.330374597616326	0.000628061862658527	miRNATAP	-0.132650787126674	3.43368574113428e-08		NA	NA	NA
hsa-miR-183-5p	RUNX1T1	-1.21596931064487	1.31473205758898e-08	-0.639456319560094	0.000483233902585183	miRNATAP	-0.181052417555696	8.94516547540757e-05		NA	NA	NA
hsa-miR-183-5p	SACS	-1.21596931064487	1.31473205758898e-08	1.32311218987972	1.438770699866e-35	MirTarget;miRNATAP	-0.115519130518289	0.000103414065399657		NA	NA	NA
hsa-miR-183-5p	SH3BP2	-1.21596931064487	1.31473205758898e-08	1.63255751161755	1.07053733479384e-48	mirMAP	-0.207031153147255	7.84152864167796e-11		NA	NA	NA
hsa-miR-183-5p	SLC2A3	-1.21596931064487	1.31473205758898e-08	2.08459818367963	3.69547285801948e-31	miRNAWalker2_validate	-0.239802212796237	1.13448937709244e-06		NA	NA	NA
hsa-miR-183-5p	SPC25	-1.21596931064487	1.31473205758898e-08	2.69575239413901	8.15451837026306e-39	MirTarget	-0.116782516886042	0.0481275503742117		NA	NA	NA
hsa-miR-183-5p	SPN	-1.21596931064487	1.31473205758898e-08	2.31394831801694	6.64102746838099e-41	mirMAP	-0.20080231975137	4.46232371701988e-05		NA	NA	NA
hsa-miR-183-5p	SPRED1	-1.21596931064487	1.31473205758898e-08	0.572476105347971	4.04715796353071e-12	miRNATAP	-0.121874055026592	7.00272207631561e-09		NA	NA	NA
hsa-miR-183-5p	ST6GALNAC3	-1.21596931064487	1.31473205758898e-08	-1.17595663696699	7.87716484543345e-14	MirTarget	-0.168756591845239	3.7956565254801e-05		NA	NA	NA
hsa-miR-183-5p	STC1	-1.21596931064487	1.31473205758898e-08	0.143301292672319	0.386348782939474	miRNATAP	-0.132943488240918	0.00136388506423353		NA	NA	NA
hsa-miR-183-5p	STX1B	-1.21596931064487	1.31473205758898e-08	1.53196339895472	5.04303612230211e-18	mirMAP	-0.253159089046665	4.53494825463793e-08		NA	NA	NA
hsa-miR-183-5p	TCF4	-1.21596931064487	1.31473205758898e-08	0.996723710324789	5.41803286352076e-15	miRNATAP	-0.225206323484239	4.43807881977879e-12		NA	NA	NA
hsa-miR-183-5p	THRA	-1.21596931064487	1.31473205758898e-08	-0.665491064627777	3.10513214370932e-14	mirMAP	-0.104048933088077	4.70512156440555e-06		NA	NA	NA
hsa-miR-183-5p	THSD7B	-1.21596931064487	1.31473205758898e-08	-0.821270123585754	0.000228493557022668	miRNATAP	-0.19402933424811	0.000585729986465947		NA	NA	NA
hsa-miR-183-5p	TMCC3	-1.21596931064487	1.31473205758898e-08	0.377407907924051	0.000504168803918484	MirTarget;miRNATAP	-0.224013056149451	1.09447871954847e-17		NA	NA	NA
hsa-miR-183-5p	TRPC6	-1.21596931064487	1.31473205758898e-08	0.424260055490409	0.00937293334818736	MirTarget	-0.180559315291951	1.00086387893764e-05		NA	NA	NA
hsa-miR-183-5p	TUB	-1.21596931064487	1.31473205758898e-08	-1.15842449577751	4.55059290414304e-08	MirTarget	-0.136992406341365	0.0120226744907776		NA	NA	NA
hsa-miR-183-5p	VASH1	-1.21596931064487	1.31473205758898e-08	2.21538949105685	1.69878350778228e-58	mirMAP	-0.228467774120164	2.25068866279291e-08		NA	NA	NA
hsa-miR-183-5p	WDFY4	-1.21596931064487	1.31473205758898e-08	2.22367944274232	5.34794937688681e-27	mirMAP	-0.113469758314927	0.0457582041663604		NA	NA	NA
hsa-miR-183-5p	ZEB1	-1.21596931064487	1.31473205758898e-08	0.51788041298344	1.55028124823622e-07	MirTarget;miRNATAP	-0.20261565132402	4.47386687992054e-17		NA	NA	NA
hsa-miR-183-5p	ZFPM2	-1.21596931064487	1.31473205758898e-08	0.229033548252102	0.125207735503825	miRNATAP	-0.178205050081131	1.6246716488724e-06		NA	NA	NA
hsa-miR-183-5p	ZNF154	-1.21596931064487	1.31473205758898e-08	0.0099258956326429	0.943705830112632	mirMAP	-0.156746674510047	7.43637434678753e-06		NA	NA	NA
hsa-miR-183-5p	ZNF395	-1.21596931064487	1.31473205758898e-08	2.36693387025551	8.80520053949467e-57	mirMAP	-0.357183729345654	7.7350621406815e-17		NA	NA	NA