miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106b-5p APC 1.07509411417907 2.11739194181878e-36 -0.15768599113557 0.0403437307908737 miRNAWalker2_validate;miRTarBase -0.249006085204911 1.29608123507827e-08 23087084 miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells liver cancer hsa-miR-193a-3p APC 0.849206638484406 3.68101781083335e-14 -0.15768599113557 0.0403437307908737 miRanda -0.106642893279778 0.0034172724513806 NA NA NA hsa-miR-21-5p APC 2.51462371613332 3.30620591950316e-66 -0.15768599113557 0.0403437307908737 miRNAWalker2_validate -0.107167440411454 4.2657877359762e-06 23773491;24832083 The prognostic significance of APC gene mutation and miR 21 expression in advanced stage colorectal cancer; The aim of this study was to analyse the association of APC gene mutation and miR-21 expression with clinical outcome in CRC patients; APC gene mutation and expression of APC and miR-21 were analysed by direct DNA sequencing and real-time reverse transcription polymerase chain reaction; APC gene expression was low in CRC and negatively correlated with miR-21 expression and gene mutation; In Taiwan downregulation of the APC gene in CRC correlated with gene mutation and miR-21 upregulation; APC mutation and miR-21 expression could be used to predict the clinical outcome of CRC especially in patients with advanced disease;MicroRNA 21 promotes tumour malignancy via increased nuclear translocation of β catenin and predicts poor outcome in APC mutated but not in APC wild type colorectal cancer; However in our preliminary data the prognostic value of miR-21 levels was observed only in adenomatous polyposis coli APC-mutated tumours not in APC-wild-type tumours; We enrolled 165 colorectal tumour to determine APC mutation miR-21 levels and nuclear β-catenin expression by direct sequencing real-time PCR and immunohistochemistry staging; colorectal cancer;colorectal cancer hsa-miR-27a-3p APC 0.558934437526245 1.44256383086177e-12 -0.15768599113557 0.0403437307908737 miRNAWalker2_validate;miRTarBase;miRNATAP -0.169866262507951 0.00114991029977032 22018270 Finally the APC gene was identified as the direct and functional target of miR-27 gastric cancer hsa-miR-590-3p APC 1.13702599385212 3.53435739887793e-22 -0.15768599113557 0.0403437307908737 PITA;miRanda;mirMAP;miRNATAP -0.108828886407415 0.00128167370350013 NA NA NA hsa-miR-199a-5p APC2 -1.64658415208633 1.01615659358973e-23 1.13536383289961 1.45436846960249e-11 mirMAP -0.174038345118553 0.0013263478313172 NA NA NA hsa-miR-30b-3p APC2 -1.64703050862226 1.89878531036464e-31 1.13536383289961 1.45436846960249e-11 MirTarget -0.278737662587965 5.61321103594452e-06 NA NA NA hsa-miR-345-5p APC2 -0.953479075875024 8.95459389953487e-14 1.13536383289961 1.45436846960249e-11 mirMAP -0.189671029522005 0.00863222439683205 NA NA NA hsa-miR-500a-3p APC2 -1.41379327701944 2.73403824528455e-37 1.13536383289961 1.45436846960249e-11 mirMAP -0.42831663479774 1.57933994893993e-08 NA NA NA hsa-miR-505-5p APC2 -0.109332726329313 0.346400159841743 1.13536383289961 1.45436846960249e-11 mirMAP -0.23808917840165 0.00409542878410238 NA NA NA hsa-miR-664a-5p APC2 -0.618481839889218 7.01961389909184e-09 1.13536383289961 1.45436846960249e-11 mirMAP -0.278213810599959 0.00155606647548434 NA NA NA hsa-miR-103a-3p AXIN2 0.779373475434461 7.37867196796994e-20 -1.42112388340711 5.69079581588302e-24 miRNAWalker2_validate;MirTarget;miRNATAP -0.316230522107144 0.00064507661434146 NA NA NA hsa-miR-107 AXIN2 0.140046250553248 0.0943611632552367 -1.42112388340711 5.69079581588302e-24 miRTarBase;MirTarget;PITA;miRanda;miRNATAP -0.373826426799397 0.000198551477693208 26191213 miR 107 promotes hepatocellular carcinoma cell proliferation by targeting Axin2; At the molecular level our results suggested that expression of Axin2 was negatively regulated by miR-107; Our observations suggested that miR-107 could promote HCC cells proliferation via targeting Axin2 and might represent a potential therapeutic target for HCC liver cancer hsa-miR-144-3p AXIN2 1.4617706700291 9.18139413836375e-11 -1.42112388340711 5.69079581588302e-24 MirTarget -0.145875129803373 4.48569552427156e-05 NA NA NA hsa-miR-15a-5p AXIN2 1.42663930007845 1.36006952074963e-57 -1.42112388340711 5.69079581588302e-24 MirTarget;miRNATAP -0.582113800525649 1.46688876992611e-14 26252081 The combination of miR-15a and AXIN2 significantly improved the diagnostic accuracy thyroid cancer hsa-miR-15b-5p AXIN2 0.773001494057531 1.71784656078957e-16 -1.42112388340711 5.69079581588302e-24 miRTarBase;MirTarget;miRNATAP -0.342724694698479 5.4245165535984e-05 NA NA NA hsa-miR-16-2-3p AXIN2 1.3046118743965 4.17207934608428e-19 -1.42112388340711 5.69079581588302e-24 mirMAP -0.240582220065484 7.0940193187666e-06 NA NA NA hsa-miR-16-5p AXIN2 0.934012514027655 4.85417898318515e-24 -1.42112388340711 5.69079581588302e-24 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.443609556369372 1.01328202128578e-07 NA NA NA hsa-miR-590-3p AXIN2 1.13702599385212 3.53435739887793e-22 -1.42112388340711 5.69079581588302e-24 MirTarget;PITA;miRanda;miRNATAP -0.382937110546424 5.07807462140002e-09 NA NA NA hsa-miR-592 AXIN2 2.6404220268798 8.81369998128794e-32 -1.42112388340711 5.69079581588302e-24 MirTarget -0.187347712491187 1.65995337955582e-08 NA NA NA hsa-miR-103a-3p BTRC 0.779373475434461 7.37867196796994e-20 -0.545867409195286 1.13119496175858e-27 MirTarget;miRNATAP -0.156858597729153 1.83104480165876e-06 NA NA NA hsa-miR-130b-3p BTRC 1.12788913578446 2.939369462276e-16 -0.545867409195286 1.13119496175858e-27 mirMAP -0.144280350974826 6.13672882734612e-13 NA NA NA hsa-miR-130b-5p BTRC 0.92990617673277 3.75880436852717e-12 -0.545867409195286 1.13119496175858e-27 mirMAP -0.105538020598352 7.69972784747403e-07 NA NA NA hsa-miR-132-3p BTRC 0.291409674711894 0.000912684337101876 -0.545867409195286 1.13119496175858e-27 MirTarget -0.129126336685942 0.0001435195224679 NA NA NA hsa-miR-15a-5p BTRC 1.42663930007845 1.36006952074963e-57 -0.545867409195286 1.13119496175858e-27 miRNAWalker2_validate;MirTarget;miRNATAP -0.230730881494424 6.85365099919491e-18 NA NA NA hsa-miR-15b-5p BTRC 0.773001494057531 1.71784656078957e-16 -0.545867409195286 1.13119496175858e-27 MirTarget;miRNATAP -0.169319296214664 1.6922104014835e-08 NA NA NA hsa-miR-16-1-3p BTRC 1.51429140700091 3.17219833254498e-37 -0.545867409195286 1.13119496175858e-27 mirMAP -0.156445074463053 1.38612815677702e-12 NA NA NA hsa-miR-16-5p BTRC 0.934012514027655 4.85417898318515e-24 -0.545867409195286 1.13119496175858e-27 miRNAWalker2_validate;MirTarget;miRNATAP -0.171318107223812 7.9595536385704e-09 NA NA NA hsa-miR-185-5p BTRC 1.05056378692621 1.31174187880682e-22 -0.545867409195286 1.13119496175858e-27 mirMAP -0.109116377207476 2.52792357758926e-05 NA NA NA hsa-miR-186-5p BTRC 0.507217561043443 9.04455748270995e-10 -0.545867409195286 1.13119496175858e-27 mirMAP -0.10428635905381 0.00333143162251156 NA NA NA hsa-miR-193a-3p BTRC 0.849206638484406 3.68101781083335e-14 -0.545867409195286 1.13119496175858e-27 MirTarget;miRanda -0.193598648122405 4.78184966244523e-15 NA NA NA hsa-miR-224-5p BTRC 2.84654230414912 3.0480927226395e-47 -0.545867409195286 1.13119496175858e-27 MirTarget -0.100839462591653 7.35998388148681e-16 NA NA NA hsa-miR-28-5p BTRC 0.461962042257226 3.32424690573327e-11 -0.545867409195286 1.13119496175858e-27 miRanda -0.205658394015241 8.44931757973945e-07 NA NA NA hsa-miR-330-5p BTRC 1.44960468659754 2.12131210588035e-45 -0.545867409195286 1.13119496175858e-27 miRNATAP -0.194106328662025 1.53951860798049e-15 NA NA NA hsa-miR-342-3p BTRC 1.4124432570595 1.07208971556131e-28 -0.545867409195286 1.13119496175858e-27 mirMAP -0.13409305784049 1.82204492764768e-10 NA NA NA hsa-miR-361-3p BTRC 1.08992546227594 1.13197240706704e-36 -0.545867409195286 1.13119496175858e-27 MirTarget;PITA;miRNATAP -0.239205646830534 1.15277659748048e-15 NA NA NA hsa-miR-576-5p BTRC 1.06681109513983 5.69294424466526e-24 -0.545867409195286 1.13119496175858e-27 mirMAP -0.12041394454881 4.10050287105916e-06 NA NA NA hsa-miR-590-3p BTRC 1.13702599385212 3.53435739887793e-22 -0.545867409195286 1.13119496175858e-27 mirMAP -0.157591361491916 1.16894853403125e-11 NA NA NA hsa-miR-629-5p BTRC 1.73389921851483 5.39614356468007e-48 -0.545867409195286 1.13119496175858e-27 mirMAP -0.168107551118532 4.65511934120712e-16 NA NA NA hsa-miR-130b-5p CAMK2A 0.92990617673277 3.75880436852717e-12 -2.93847144618389 2.22710677475889e-27 mirMAP -0.476931802633735 4.60168099210164e-05 NA NA NA hsa-miR-142-5p CAMK2A 1.88417391525707 1.2096808039882e-27 -2.93847144618389 2.22710677475889e-27 PITA;miRNATAP -0.470432921017169 3.06600800544443e-08 NA NA NA hsa-miR-144-3p CAMK2A 1.4617706700291 9.18139413836375e-11 -2.93847144618389 2.22710677475889e-27 mirMAP -0.191847141744015 0.00625690420738992 NA NA NA hsa-miR-146b-3p CAMK2A 1.20941495066078 2.12939149602665e-10 -2.93847144618389 2.22710677475889e-27 miRNATAP -0.303248251648458 0.000248319503715044 NA NA NA hsa-miR-148a-3p CAMK2A 0.343233211643815 0.00402279073598165 -2.93847144618389 2.22710677475889e-27 miRNATAP -0.492646326770434 0.000288923117505384 NA NA NA hsa-miR-15b-3p CAMK2A 1.49422666971434 5.44139893275088e-29 -2.93847144618389 2.22710677475889e-27 mirMAP -0.753671582677768 3.42721137061698e-12 NA NA NA hsa-miR-185-5p CAMK2A 1.05056378692621 1.31174187880682e-22 -2.93847144618389 2.22710677475889e-27 mirMAP -1.05462970314089 1.23954644796603e-14 NA NA NA hsa-miR-19b-1-5p CAMK2A 0.66692013055553 1.55789130176287e-09 -2.93847144618389 2.22710677475889e-27 mirMAP -0.720863774110313 4.44855828833789e-07 NA NA NA hsa-miR-21-3p CAMK2A 1.78837590049697 1.41655409877312e-33 -2.93847144618389 2.22710677475889e-27 MirTarget -0.74193301310208 6.54984927634249e-15 NA NA NA hsa-miR-25-3p CAMK2A 1.12016166564779 3.79069348635778e-48 -2.93847144618389 2.22710677475889e-27 MirTarget -1.44682744061332 1.92169211192131e-16 NA NA NA hsa-miR-27a-3p CAMK2A 0.558934437526245 1.44256383086177e-12 -2.93847144618389 2.22710677475889e-27 mirMAP;miRNATAP -0.830797950561433 3.27942474333645e-05 NA NA NA hsa-miR-30e-5p CAMK2A -0.0905907245198101 0.21196704484334 -2.93847144618389 2.22710677475889e-27 mirMAP -0.627848243448903 0.00595840366765784 NA NA NA hsa-miR-331-3p CAMK2A 0.431607034018882 6.83022920590941e-05 -2.93847144618389 2.22710677475889e-27 MirTarget -0.463031623683369 0.00193665578236664 NA NA NA hsa-miR-340-5p CAMK2A 1.14479851941741 2.91936881701444e-15 -2.93847144618389 2.22710677475889e-27 mirMAP -0.602783625466634 1.12080831874122e-08 NA NA NA hsa-miR-361-3p CAMK2A 1.08992546227594 1.13197240706704e-36 -2.93847144618389 2.22710677475889e-27 mirMAP -1.1259319709343 8.57714768635708e-12 NA NA NA hsa-miR-3913-5p CAMK2A 0.136365354811444 0.24239516424369 -2.93847144618389 2.22710677475889e-27 mirMAP -0.446549455427698 0.00244202358748183 NA NA NA hsa-miR-452-3p CAMK2A 1.72039996672257 1.35748079442153e-22 -2.93847144618389 2.22710677475889e-27 mirMAP -0.494464455701971 1.12941070297294e-08 NA NA NA hsa-miR-455-5p CAMK2A 0.773674551205946 2.12957541541474e-09 -2.93847144618389 2.22710677475889e-27 MirTarget;miRanda -0.380881375491336 0.00197600056749574 NA NA NA hsa-miR-616-5p CAMK2A 0.913426384742148 3.78418389333709e-09 -2.93847144618389 2.22710677475889e-27 mirMAP -0.532473776633855 2.27791300435618e-07 NA NA NA hsa-miR-7-1-3p CAMK2A 0.544601828025304 5.33830451326047e-07 -2.93847144618389 2.22710677475889e-27 MirTarget -0.795045587607697 4.87668536858379e-08 NA NA NA hsa-miR-92b-3p CAMK2A 0.418630595140165 6.50466149211154e-05 -2.93847144618389 2.22710677475889e-27 MirTarget -0.620943663054378 5.36906313447829e-05 NA NA NA hsa-miR-1271-5p CAMK2B 0.900599702972936 3.07963385418853e-10 -1.83821839806386 4.53154140077029e-10 mirMAP -0.473565072701234 2.77295285780584e-05 NA NA NA hsa-miR-150-5p CAMK2B 1.00371863159681 1.09871676395528e-09 -1.83821839806386 4.53154140077029e-10 mirMAP -0.2982659953378 0.00255371579358295 NA NA NA hsa-miR-186-5p CAMK2B 0.507217561043443 9.04455748270995e-10 -1.83821839806386 4.53154140077029e-10 miRNAWalker2_validate;miRNATAP -0.779012997788771 8.09791179586604e-05 NA NA NA hsa-miR-193a-3p CAMK2B 0.849206638484406 3.68101781083335e-14 -1.83821839806386 4.53154140077029e-10 mirMAP -0.680968664308727 1.71117724038529e-06 NA NA NA hsa-miR-2355-3p CAMK2B 1.32757890426926 1.88016636795886e-18 -1.83821839806386 4.53154140077029e-10 miRNATAP -0.361199107991937 0.000741012492621338 NA NA NA hsa-miR-2355-5p CAMK2B 1.57515081110162 3.54962327490702e-48 -1.83821839806386 4.53154140077029e-10 mirMAP -0.94099087291293 2.99591197668405e-13 NA NA NA hsa-miR-361-3p CAMK2B 1.08992546227594 1.13197240706704e-36 -1.83821839806386 4.53154140077029e-10 MirTarget;miRNATAP -0.698449548715254 5.51514444301177e-05 NA NA NA hsa-miR-590-3p CAMK2B 1.13702599385212 3.53435739887793e-22 -1.83821839806386 4.53154140077029e-10 miRanda -0.54665324481516 3.86219040687823e-05 NA NA NA hsa-miR-628-5p CAMK2B -0.293936745442736 0.0769541076905808 -1.83821839806386 4.53154140077029e-10 miRNATAP -0.280329885604739 0.00534128497942237 NA NA NA hsa-miR-30b-5p CAMK2D -1.18330589477119 6.8341618466966e-27 0.240127172658343 0.000201329262483378 miRNATAP -0.101464809411166 0.000687148213358162 NA NA NA hsa-miR-17-3p CAMK2G 0.723795600017259 5.90151677164931e-18 -0.427172447749085 8.71977748058711e-13 miRNATAP -0.168024912129934 1.26594801903817e-05 NA NA NA hsa-miR-181b-5p CAMK2G 1.49054296272357 3.69051660739368e-41 -0.427172447749085 8.71977748058711e-13 miRNATAP -0.107160272490417 6.61172306710736e-05 NA NA NA hsa-miR-193a-5p CAMK2G 1.29777740059595 2.16815694068336e-39 -0.427172447749085 8.71977748058711e-13 miRNATAP -0.205184351996412 4.43127317291987e-12 NA NA NA hsa-miR-590-3p CAMK2G 1.13702599385212 3.53435739887793e-22 -0.427172447749085 8.71977748058711e-13 miRanda -0.114595876425634 2.17544224088354e-05 NA NA NA hsa-let-7e-5p CCND1 -0.727009689927955 1.30690859412163e-11 2.13480598480786 2.71111034411853e-47 miRTarBase;miRNATAP -0.309874613270473 0.000283950841354646 NA NA NA hsa-let-7g-5p CCND1 -0.739744008507763 1.07979566264383e-14 2.13480598480786 2.71111034411853e-47 miRNATAP -0.622969784922631 1.85126618527679e-11 NA NA NA hsa-miR-106a-5p CCND1 -0.830908656792615 2.67547872901508e-10 2.13480598480786 2.71111034411853e-47 MirTarget;miRNATAP -0.425464553504269 5.26102842088565e-10 NA NA NA hsa-miR-135a-5p CCND1 -2.13422485001223 6.29449029671498e-14 2.13480598480786 2.71111034411853e-47 mirMAP -0.135832732621826 2.9303290026017e-05 NA NA NA hsa-miR-183-5p CCND1 -1.21596931064487 1.31473205758898e-08 2.13480598480786 2.71111034411853e-47 miRNAWalker2_validate -0.374903452579708 3.93459169450664e-20 NA NA NA hsa-miR-193b-3p CCND1 -0.273325765316079 0.104328826585392 2.13480598480786 2.71111034411853e-47 miRNAWalker2_validate;miRTarBase;MirTarget -0.242980057535361 1.3298535415108e-05 27071318;20655737;20304954;21893020;26129688 MicroRNA 193b inhibits the proliferation migration and invasion of gastric cancer cells via targeting cyclin D1; Further mechanism study indicated that CCND1 was a direct target of miR-193b in GC;CCND1 and ETS1 were revealed to be regulated by miR-193b directly;MicroRNA 193b represses cell proliferation and regulates cyclin D1 in melanoma; Overexpression of miR-193b in Malme-3M cells down-regulated CCND1 mRNA and protein by > or = 50%; A luciferase reporter assay confirmed that miR-193b directly regulates CCND1 by binding to the 3'untranslated region of CCND1 mRNA; These studies indicate that miR-193b represses cell proliferation and regulates CCND1 expression and suggest that dysregulation of miR-193b may play an important role in melanoma development;In a previous study we reported that miR-193b represses cell proliferation and regulates cyclin D1 in melanoma cells suggesting that miR-193b could act as a tumor suppressor;Epigenetically altered miR 193b targets cyclin D1 in prostate cancer; It has been suggested that miR-193b targets cyclin D1 in several malignancies; Here our aim was to determine if miR-193b targets cyclin D1 in prostate cancer; Furthermore the PC cell lines 22Rv1 and VCaP which express low levels of miR-193b and high levels of CCND1 showed significant growth retardation when treated with a CDK4/6 inhibitor; In contrast the inhibitor had no effect on the growth of PC-3 and DU145 cells with high miR-193b and low CCND1 expression; Taken together our data demonstrate that miR-193b targets cyclin D1 in prostate cancer ;;;; gastric cancer;liver cancer;melanoma;melanoma;prostate cancer hsa-miR-20b-5p CCND1 -1.30218163823367 6.87172815978149e-17 2.13480598480786 2.71111034411853e-47 MirTarget;miRNATAP -0.398854407061578 1.06454795591623e-12 NA NA NA hsa-miR-214-5p CCND1 -1.44418790803397 1.50873538772684e-16 2.13480598480786 2.71111034411853e-47 MirTarget -0.347168835410485 4.02103564566879e-12 NA NA NA hsa-miR-29a-3p CCND1 -0.431613225927952 4.10166815070288e-08 2.13480598480786 2.71111034411853e-47 mirMAP -0.939711765610188 1.68520368520268e-16 NA NA NA hsa-miR-29b-3p CCND1 -0.228125979913806 0.0271621721891603 2.13480598480786 2.71111034411853e-47 mirMAP -0.387608162335363 2.20893060555751e-05 NA NA NA hsa-miR-495-3p CCND1 -0.742293735164333 7.11373308013543e-05 2.13480598480786 2.71111034411853e-47 MirTarget -0.181526805649212 0.000432098784713278 NA NA NA hsa-miR-9-5p CCND1 -2.23538606210968 1.28143998950751e-12 2.13480598480786 2.71111034411853e-47 miRNAWalker2_validate -0.163701601563252 7.92305196930194e-09 NA NA NA hsa-let-7e-5p CCND2 -0.727009689927955 1.30690859412163e-11 1.12254248674744 2.60370825886318e-19 miRNATAP -0.233612834039481 0.000392482925172286 NA NA NA hsa-let-7g-5p CCND2 -0.739744008507763 1.07979566264383e-14 1.12254248674744 2.60370825886318e-19 miRNATAP -0.192686043584521 0.0089075831083671 NA NA NA hsa-miR-106a-5p CCND2 -0.830908656792615 2.67547872901508e-10 1.12254248674744 2.60370825886318e-19 miRNATAP -0.225423059951479 2.69299129795332e-05 NA NA NA hsa-miR-10a-3p CCND2 -1.40380922426511 3.42207767326254e-23 1.12254248674744 2.60370825886318e-19 mirMAP -0.262198638789585 6.25176630952157e-08 NA NA NA hsa-miR-10b-3p CCND2 -0.8205021989966 7.84331443044781e-21 1.12254248674744 2.60370825886318e-19 mirMAP -0.448238682535571 6.77944940531982e-09 NA NA NA hsa-miR-135a-5p CCND2 -2.13422485001223 6.29449029671498e-14 1.12254248674744 2.60370825886318e-19 miRNATAP -0.131225655723756 1.33192381495194e-07 NA NA NA hsa-miR-141-3p CCND2 -5.87110686537457 1.20877726722907e-85 1.12254248674744 2.60370825886318e-19 MirTarget;TargetScan -0.139228651988037 1.29114997683213e-14 NA NA NA hsa-miR-188-5p CCND2 -1.74586655806628 1.50431624674552e-28 1.12254248674744 2.60370825886318e-19 PITA;mirMAP -0.254549789518694 2.9475657150123e-09 NA NA NA hsa-miR-200a-3p CCND2 -1.43409013664263 2.00188483717828e-20 1.12254248674744 2.60370825886318e-19 MirTarget -0.212833658265287 1.19682362163716e-06 NA NA NA hsa-miR-20b-5p CCND2 -1.30218163823367 6.87172815978149e-17 1.12254248674744 2.60370825886318e-19 miRNATAP -0.259528470369076 2.90568654364943e-09 NA NA NA hsa-miR-26a-1-3p CCND2 -1.56107117111696 6.75439319582901e-15 1.12254248674744 2.60370825886318e-19 mirMAP -0.123054440828334 0.000561186412955267 NA NA NA hsa-miR-29a-3p CCND2 -0.431613225927952 4.10166815070288e-08 1.12254248674744 2.60370825886318e-19 MirTarget;miRNATAP -0.257180845680541 0.00521051024582081 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-29a-5p CCND2 -0.519003718107105 1.03351148282116e-06 1.12254248674744 2.60370825886318e-19 mirMAP -0.175805947483669 0.00980240816278221 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-29c-3p CCND2 -0.238671318446745 0.0141475322347596 1.12254248674744 2.60370825886318e-19 MirTarget;miRNATAP -0.244609702834514 0.0011551466386057 NA NA NA hsa-miR-3065-3p CCND2 -1.64500070417457 9.57561660036697e-16 1.12254248674744 2.60370825886318e-19 MirTarget;miRNATAP -0.15735746874687 2.91648572740269e-06 NA NA NA hsa-miR-30a-3p CCND2 -0.955360819934585 1.97009535429185e-20 1.12254248674744 2.60370825886318e-19 mirMAP -0.322061265215125 1.10079970812633e-06 NA NA NA hsa-miR-30d-3p CCND2 -0.249777194282131 0.00235356711813496 1.12254248674744 2.60370825886318e-19 mirMAP -0.528583706650002 1.57965043070812e-09 NA NA NA hsa-miR-335-5p CCND2 -2.09515619961552 1.03765771499548e-25 1.12254248674744 2.60370825886318e-19 miRNAWalker2_validate -0.125391196936535 0.000218373131234068 NA NA NA hsa-miR-378a-3p CCND2 0.287244802401236 0.0501155019984562 1.12254248674744 2.60370825886318e-19 miRNAWalker2_validate -0.155216456838451 0.00181246322617494 NA NA NA hsa-miR-429 CCND2 -2.16569233119434 2.66862243626443e-37 1.12254248674744 2.60370825886318e-19 miRNATAP -0.226547302813025 1.44251591184469e-09 NA NA NA hsa-miR-500a-5p CCND2 -1.28374735824553 1.95870374809798e-20 1.12254248674744 2.60370825886318e-19 mirMAP -0.227276642384328 3.82424468920894e-06 NA NA NA hsa-miR-501-5p CCND2 -1.1103073934745 1.81589804886553e-16 1.12254248674744 2.60370825886318e-19 PITA;mirMAP;miRNATAP -0.210338351972789 4.15719063926169e-05 NA NA NA hsa-miR-577 CCND2 -1.48881999472397 7.03080165111147e-10 1.12254248674744 2.60370825886318e-19 PITA;mirMAP -0.106625188470732 0.000293795265070961 NA NA NA hsa-miR-660-5p CCND2 -1.20833564582661 8.48975910642834e-23 1.12254248674744 2.60370825886318e-19 mirMAP -0.376740011929223 2.58290869632093e-12 NA NA NA hsa-miR-362-3p CCND3 -0.753214251798232 3.0025661608035e-07 0.51821271483815 4.41964906922001e-09 miRanda -0.139754455099983 4.25864164139051e-05 NA NA NA hsa-miR-501-5p CCND3 -1.1103073934745 1.81589804886553e-16 0.51821271483815 4.41964906922001e-09 PITA -0.131433527243481 0.000178229069185252 NA NA NA hsa-miR-24-3p CHD8 0.173813044685099 0.00565259443420961 -0.24974847699517 4.60073888105766e-06 miRNAWalker2_validate -0.163572784577081 0.000838094842612991 NA NA NA hsa-miR-365a-3p CHD8 0.80809616164259 2.36039522526e-12 -0.24974847699517 4.60073888105766e-06 miRNATAP -0.161558429622462 7.31856679456802e-11 NA NA NA hsa-miR-590-3p CHD8 1.13702599385212 3.53435739887793e-22 -0.24974847699517 4.60073888105766e-06 miRanda -0.101396376684679 2.45483177234556e-05 NA NA NA hsa-miR-590-5p CHD8 0.709763558412506 1.11883921359361e-11 -0.24974847699517 4.60073888105766e-06 miRanda -0.10371644181571 0.000218888641262621 NA NA NA hsa-miR-106b-5p CHP2 1.07509411417907 2.11739194181878e-36 -4.85824590499015 3.05626798767572e-58 MirTarget -1.58995368270032 4.17510489844563e-15 NA NA NA hsa-miR-17-5p CHP2 0.494260110870015 3.8348005261e-09 -4.85824590499015 3.05626798767572e-58 MirTarget -1.05293982395628 6.26552263101198e-06 NA NA NA hsa-miR-20a-5p CHP2 0.702602695798242 4.06372887613329e-13 -4.85824590499015 3.05626798767572e-58 MirTarget -1.26631554399921 8.83278262712219e-11 NA NA NA hsa-miR-224-5p CHP2 2.84654230414912 3.0480927226395e-47 -4.85824590499015 3.05626798767572e-58 MirTarget -0.806037485399145 6.26769397013649e-23 NA NA NA hsa-miR-320a CHP2 0.412740558379182 2.02929519701706e-05 -4.85824590499015 3.05626798767572e-58 miRanda -0.731704395825421 0.000358100930886103 NA NA NA hsa-miR-93-5p CHP2 1.37365940377595 2.37567548683245e-46 -4.85824590499015 3.05626798767572e-58 MirTarget -1.74045083301575 3.782182814463e-25 NA NA NA hsa-miR-30a-5p CSNK1A1 -0.778411951775343 2.73322451127932e-16 0.343559866389969 8.30852755010977e-13 MirTarget;miRNATAP -0.164217020668093 9.83302064299617e-10 NA NA NA hsa-miR-30b-5p CSNK1A1 -1.18330589477119 6.8341618466966e-27 0.343559866389969 8.30852755010977e-13 MirTarget;mirMAP;miRNATAP -0.158697093332905 6.58692522483172e-13 NA NA NA hsa-miR-30c-5p CSNK1A1 -1.08783070774238 2.02505402525786e-24 0.343559866389969 8.30852755010977e-13 MirTarget;mirMAP;miRNATAP -0.132951914009211 1.2377491841124e-08 NA NA NA hsa-miR-30d-5p CSNK1A1 -0.202727675788184 0.00659067084745794 0.343559866389969 8.30852755010977e-13 MirTarget;miRNATAP -0.140538167988401 0.000129354819199596 NA NA NA hsa-miR-502-3p CSNK1A1 -1.10416310320528 1.55354569985732e-22 0.343559866389969 8.30852755010977e-13 miRNATAP -0.130922496393459 3.17922619059171e-09 NA NA NA hsa-miR-149-5p CSNK1E -1.95790336710741 8.46371715052367e-27 1.01039126608085 6.48810251758301e-40 miRNAWalker2_validate -0.155001487088013 3.55448762097709e-11 NA NA NA hsa-miR-30a-3p CSNK1E -0.955360819934585 1.97009535429185e-20 1.01039126608085 6.48810251758301e-40 miRNATAP -0.347530700463454 7.93808645307933e-17 NA NA NA hsa-miR-30c-5p CSNK1E -1.08783070774238 2.02505402525786e-24 1.01039126608085 6.48810251758301e-40 miRNAWalker2_validate -0.328790062078608 1.44814431919771e-16 NA NA NA hsa-miR-30d-3p CSNK1E -0.249777194282131 0.00235356711813496 1.01039126608085 6.48810251758301e-40 miRNATAP -0.154842507840326 0.00812535868602463 NA NA NA hsa-miR-362-3p CSNK1E -0.753214251798232 3.0025661608035e-07 1.01039126608085 6.48810251758301e-40 miRanda -0.111227437500845 0.000707090480565381 NA NA NA hsa-miR-429 CSNK1E -2.16569233119434 2.66862243626443e-37 1.01039126608085 6.48810251758301e-40 miRNATAP -0.205975413297079 4.34082584281407e-18 NA NA NA hsa-miR-26a-5p CSNK2A1 -0.202091714279613 0.00166918288801054 -0.1229054883024 0.0326941180240784 mirMAP -0.176800607394779 0.00037624287464926 NA NA NA hsa-miR-26b-5p CSNK2A1 -0.251437253429904 0.00270935785098697 -0.1229054883024 0.0326941180240784 mirMAP -0.112140734297613 0.00307068938299079 NA NA NA hsa-miR-23b-3p CSNK2A2 -0.533749586990474 2.46924776953771e-10 0.287191833023478 1.63426128888767e-07 miRNATAP -0.133923235907684 0.000160344775215979 NA NA NA hsa-miR-30c-5p CSNK2A2 -1.08783070774238 2.02505402525786e-24 0.287191833023478 1.63426128888767e-07 mirMAP -0.128167937090818 1.23362011905363e-06 NA NA NA hsa-miR-10b-5p CTBP1 -0.89971464210447 1.18190532299934e-20 0.343157054749229 1.70497605764461e-10 miRNAWalker2_validate -0.169551641028977 5.50059572178262e-09 NA NA NA hsa-miR-28-5p CTNNB1 0.461962042257226 3.32424690573327e-11 -0.220709664881213 0.00129454639929481 miRanda -0.146958614625593 0.0061343910985911 NA NA NA hsa-miR-34a-5p CTNNB1 1.07544567720768 1.81510842038009e-20 -0.220709664881213 0.00129454639929481 miRNAWalker2_validate -0.145558388061578 1.77642044170244e-06 NA NA NA hsa-miR-589-5p CTNNB1 0.696241532021631 5.26958362886071e-16 -0.220709664881213 0.00129454639929481 miRNATAP -0.212332596763495 4.03527705083217e-07 NA NA NA hsa-miR-590-3p CTNNB1 1.13702599385212 3.53435739887793e-22 -0.220709664881213 0.00129454639929481 miRanda -0.16927364598531 1.27863235456847e-08 NA NA NA hsa-miR-23a-3p CTNNBIP1 0.761438723382355 4.09310879199257e-27 -0.675840312450778 8.13486370462243e-25 MirTarget;miRNATAP -0.214005681118394 2.813754674911e-05 NA NA NA hsa-miR-27b-3p CUL1 -0.699527231242518 1.07356023759234e-15 0.298957922803077 4.90293521921766e-13 miRNAWalker2_validate -0.188711638059524 3.40675052530908e-14 NA NA NA hsa-miR-130b-3p CXXC4 1.12788913578446 2.939369462276e-16 0.2523895396889 0.237434062959087 miRNATAP -0.225207532070542 0.00580164171013356 NA NA NA hsa-miR-223-3p CXXC4 1.23291409735619 1.07767240442694e-17 0.2523895396889 0.237434062959087 MirTarget -0.230059457402566 0.00303698173917519 NA NA NA hsa-miR-301a-3p CXXC4 0.259400847075798 0.0216890736701418 0.2523895396889 0.237434062959087 miRNATAP -0.283144425996643 0.00674140227964399 NA NA NA hsa-miR-429 CXXC4 -2.16569233119434 2.66862243626443e-37 0.2523895396889 0.237434062959087 miRNATAP -0.206430085347159 0.000795480978409034 NA NA NA hsa-miR-501-5p CXXC4 -1.1103073934745 1.81589804886553e-16 0.2523895396889 0.237434062959087 mirMAP -0.282127805470135 0.000683030236681386 NA NA NA hsa-miR-532-5p CXXC4 -1.09700348358668 8.34836230254408e-26 0.2523895396889 0.237434062959087 MirTarget;PITA;miRNATAP -0.32563948928891 0.00181871502351811 NA NA NA hsa-miR-589-5p CXXC4 0.696241532021631 5.26958362886071e-16 0.2523895396889 0.237434062959087 MirTarget;miRNATAP -0.347339138429065 0.00852190911666645 NA NA NA hsa-miR-660-5p CXXC4 -1.20833564582661 8.48975910642834e-23 0.2523895396889 0.237434062959087 miRNATAP -0.238233094992417 0.00783793583081886 NA NA NA hsa-miR-664a-3p CXXC4 -0.019312777079624 0.825861598748857 0.2523895396889 0.237434062959087 mirMAP -0.392382812061083 0.00382253690463275 NA NA NA hsa-let-7f-1-3p DAAM1 0.477913872379336 4.46669616865068e-05 -1.38986870958534 2.01416441883087e-27 MirTarget -0.266147077169672 0.000155165894205913 NA NA NA hsa-miR-130b-3p DAAM1 1.12788913578446 2.939369462276e-16 -1.38986870958534 2.01416441883087e-27 MirTarget;miRNATAP -0.371358349964309 6.0283776331627e-13 NA NA NA hsa-miR-130b-5p DAAM1 0.92990617673277 3.75880436852717e-12 -1.38986870958534 2.01416441883087e-27 MirTarget -0.290414872458135 1.1523601578309e-07 NA NA NA hsa-miR-132-3p DAAM1 0.291409674711894 0.000912684337101876 -1.38986870958534 2.01416441883087e-27 MirTarget;miRNATAP -0.242771051459871 0.00571732593295426 NA NA NA hsa-miR-140-5p DAAM1 0.504309496243674 3.09884038729031e-11 -1.38986870958534 2.01416441883087e-27 miRanda -0.265791052167246 0.00759595144732188 NA NA NA hsa-miR-142-3p DAAM1 1.88928758773299 2.72985643829893e-22 -1.38986870958534 2.01416441883087e-27 miRanda -0.235415830633107 5.70255751924188e-11 NA NA NA hsa-miR-181a-5p DAAM1 1.11111114875339 3.97880443756442e-29 -1.38986870958534 2.01416441883087e-27 mirMAP -0.450932629930499 8.09337876973387e-11 NA NA NA hsa-miR-181b-5p DAAM1 1.49054296272357 3.69051660739368e-41 -1.38986870958534 2.01416441883087e-27 mirMAP -0.495956356658024 1.6083825426813e-17 NA NA NA hsa-miR-186-5p DAAM1 0.507217561043443 9.04455748270995e-10 -1.38986870958534 2.01416441883087e-27 MirTarget;mirMAP -0.48921269662618 5.38440473069272e-08 NA NA NA hsa-miR-194-5p DAAM1 0.62222617402691 0.00659826803316099 -1.38986870958534 2.01416441883087e-27 miRNATAP -0.109016213266915 0.00108023805199841 NA NA NA hsa-miR-19a-3p DAAM1 0.722913586880779 2.76301458932381e-10 -1.38986870958534 2.01416441883087e-27 miRNATAP -0.351599128009484 4.97135968235782e-08 NA NA NA hsa-miR-19b-3p DAAM1 0.195940928879427 0.0300512922542325 -1.38986870958534 2.01416441883087e-27 miRNATAP -0.291076725841055 0.00066990545026234 NA NA NA hsa-miR-21-5p DAAM1 2.51462371613332 3.30620591950316e-66 -1.38986870958534 2.01416441883087e-27 miRNAWalker2_validate -0.45537803282989 1.02242031520024e-31 NA NA NA hsa-miR-27a-3p DAAM1 0.558934437526245 1.44256383086177e-12 -1.38986870958534 2.01416441883087e-27 miRNATAP -0.643166098224546 3.10840115837259e-12 NA NA NA hsa-miR-301a-3p DAAM1 0.259400847075798 0.0216890736701418 -1.38986870958534 2.01416441883087e-27 MirTarget;miRNATAP -0.204562677085187 0.00270647091036666 NA NA NA hsa-miR-32-5p DAAM1 0.407826130035097 7.26884631998646e-06 -1.38986870958534 2.01416441883087e-27 miRNATAP -0.339593690364684 4.93415493071646e-05 NA NA NA hsa-miR-320a DAAM1 0.412740558379182 2.02929519701706e-05 -1.38986870958534 2.01416441883087e-27 miRanda -0.29337321182106 0.000193518552175028 NA NA NA hsa-miR-320b DAAM1 0.300497419754843 0.0245219177384172 -1.38986870958534 2.01416441883087e-27 miRanda -0.192569622724032 0.000803560490938774 NA NA NA hsa-miR-34a-5p DAAM1 1.07544567720768 1.81510842038009e-20 -1.38986870958534 2.01416441883087e-27 MirTarget;miRNATAP -0.453960932630764 5.0139591429096e-14 NA NA NA hsa-miR-452-5p DAAM1 2.05325688842141 2.82238393643084e-40 -1.38986870958534 2.01416441883087e-27 MirTarget -0.365532904160887 1.65318697920566e-18 NA NA NA hsa-miR-454-3p DAAM1 0.68285296887698 1.17407812677787e-08 -1.38986870958534 2.01416441883087e-27 MirTarget;miRNATAP -0.308968158429708 6.89156804166068e-07 NA NA NA hsa-miR-576-5p DAAM1 1.06681109513983 5.69294424466526e-24 -1.38986870958534 2.01416441883087e-27 mirMAP -0.372536967002041 2.39822519550711e-08 NA NA NA hsa-miR-590-3p DAAM1 1.13702599385212 3.53435739887793e-22 -1.38986870958534 2.01416441883087e-27 MirTarget;miRanda;mirMAP -0.441192405123066 1.06417018338291e-13 NA NA NA hsa-miR-92b-3p DAAM1 0.418630595140165 6.50466149211154e-05 -1.38986870958534 2.01416441883087e-27 miRNATAP -0.40318660519706 1.92528266517812e-08 NA NA NA hsa-miR-1270 DAAM2 1.71697026896618 1.75919401373445e-16 -0.0168079014297424 0.896811016854793 miRNATAP -0.10342827787772 0.00151080328041532 NA NA NA hsa-miR-182-5p DAAM2 -0.608710746044567 0.0025264935278104 -0.0168079014297424 0.896811016854793 mirMAP -0.102540892743576 0.00353247717038806 NA NA NA hsa-miR-1976 DAAM2 0.343475600930938 0.000360243844871748 -0.0168079014297424 0.896811016854793 mirMAP -0.276980795518083 0.000170010273723771 NA NA NA hsa-miR-339-5p DAAM2 0.322848334531193 0.0117281778821612 -0.0168079014297424 0.896811016854793 miRanda -0.1682382859173 0.00247572110917687 NA NA NA hsa-miR-429 DAAM2 -2.16569233119434 2.66862243626443e-37 -0.0168079014297424 0.896811016854793 miRNATAP -0.113810420749712 0.00229047416788168 NA NA NA hsa-miR-589-3p DAAM2 -0.0184909376114044 0.903149951095234 -0.0168079014297424 0.896811016854793 mirMAP -0.149564317369541 0.00179143775108115 NA NA NA hsa-miR-590-3p DAAM2 1.13702599385212 3.53435739887793e-22 -0.0168079014297424 0.896811016854793 miRanda;mirMAP -0.181792067108766 0.00140278024034593 NA NA NA hsa-miR-217 DKK1 -1.32414431829977 4.20138196453017e-06 0.0492764483297469 0.828604787964088 miRanda;miRNATAP -0.123729232964846 0.0039417125206431 NA NA NA hsa-miR-29b-2-5p DVL3 -0.297854154636098 0.00260919277325581 0.0517387826509061 0.331393289501179 MirTarget -0.146756419924725 4.57749287388624e-07 NA NA NA hsa-miR-106b-5p EP300 1.07509411417907 2.11739194181878e-36 -0.147148678710588 0.0405321000139646 miRNATAP -0.261995772265445 1.08364064661463e-10 NA NA NA hsa-miR-186-5p EP300 0.507217561043443 9.04455748270995e-10 -0.147148678710588 0.0405321000139646 miRNATAP -0.121597586405933 0.00972259491444961 NA NA NA hsa-miR-22-3p EP300 0.198460552200729 0.00761005672059428 -0.147148678710588 0.0405321000139646 MirTarget;miRNATAP -0.164572270687749 0.00217699129328605 NA NA NA hsa-miR-26b-5p EP300 -0.251437253429904 0.00270935785098697 -0.147148678710588 0.0405321000139646 miRNAWalker2_validate;miRNATAP -0.150155147849394 0.00151617840802469 NA NA NA hsa-miR-339-5p EP300 0.322848334531193 0.0117281778821612 -0.147148678710588 0.0405321000139646 miRanda -0.150136558180177 8.30541099155694e-07 NA NA NA hsa-miR-361-3p EP300 1.08992546227594 1.13197240706704e-36 -0.147148678710588 0.0405321000139646 PITA -0.124298281144442 0.00252789477423822 NA NA NA hsa-miR-106b-5p FBXW11 1.07509411417907 2.11739194181878e-36 -0.382333893897273 1.04530841856519e-08 miRNATAP -0.338043846287292 1.65431880521891e-19 NA NA NA hsa-miR-130b-3p FBXW11 1.12788913578446 2.939369462276e-16 -0.382333893897273 1.04530841856519e-08 MirTarget -0.189261540770142 4.38241409739157e-14 NA NA NA hsa-miR-142-5p FBXW11 1.88417391525707 1.2096808039882e-27 -0.382333893897273 1.04530841856519e-08 PITA -0.108241212306481 3.21826120985363e-08 NA NA NA hsa-miR-16-1-3p FBXW11 1.51429140700091 3.17219833254498e-37 -0.382333893897273 1.04530841856519e-08 MirTarget -0.104073201173029 0.000261853883561163 NA NA NA hsa-miR-16-5p FBXW11 0.934012514027655 4.85417898318515e-24 -0.382333893897273 1.04530841856519e-08 miRNAWalker2_validate -0.147206592375098 9.85425588929349e-05 NA NA NA hsa-miR-17-5p FBXW11 0.494260110870015 3.8348005261e-09 -0.382333893897273 1.04530841856519e-08 TargetScan;miRNATAP -0.156412997952024 0.000374404469491881 NA NA NA hsa-miR-19a-3p FBXW11 0.722913586880779 2.76301458932381e-10 -0.382333893897273 1.04530841856519e-08 MirTarget -0.140150302474319 9.89343645640583e-06 NA NA NA hsa-miR-19b-3p FBXW11 0.195940928879427 0.0300512922542325 -0.382333893897273 1.04530841856519e-08 MirTarget -0.176331628905591 2.19567174934386e-05 NA NA NA hsa-miR-20a-5p FBXW11 0.702602695798242 4.06372887613329e-13 -0.382333893897273 1.04530841856519e-08 miRNATAP -0.150046860185627 5.85922335239707e-05 NA NA NA hsa-miR-301a-3p FBXW11 0.259400847075798 0.0216890736701418 -0.382333893897273 1.04530841856519e-08 MirTarget -0.123526207315598 0.000194838076744278 NA NA NA hsa-miR-320a FBXW11 0.412740558379182 2.02929519701706e-05 -0.382333893897273 1.04530841856519e-08 PITA;miRanda -0.111000719395279 0.004005215483286 NA NA NA hsa-miR-330-3p FBXW11 0.912906550436308 3.35037014057665e-13 -0.382333893897273 1.04530841856519e-08 MirTarget;PITA;miRNATAP -0.103576784548662 0.000432831545200346 NA NA NA hsa-miR-374a-5p FBXW11 0.543061152108237 2.19403097299769e-14 -0.382333893897273 1.04530841856519e-08 mirMAP -0.140233760313555 0.00639802178124422 NA NA NA hsa-miR-454-3p FBXW11 0.68285296887698 1.17407812677787e-08 -0.382333893897273 1.04530841856519e-08 MirTarget -0.125774144594795 3.83345002298946e-05 NA NA NA hsa-miR-590-3p FBXW11 1.13702599385212 3.53435739887793e-22 -0.382333893897273 1.04530841856519e-08 mirMAP -0.160344943680569 5.66145570232005e-08 NA NA NA hsa-miR-93-5p FBXW11 1.37365940377595 2.37567548683245e-46 -0.382333893897273 1.04530841856519e-08 miRNATAP -0.175690890211501 1.47862966783533e-07 NA NA NA hsa-miR-429 FOSL1 -2.16569233119434 2.66862243626443e-37 0.740114268333266 0.00163259746736155 miRanda;miRNATAP -0.216325791865205 0.00151316729228971 NA NA NA hsa-miR-22-3p FRAT2 0.198460552200729 0.00761005672059428 -0.49660955526236 6.4322474945319e-12 miRNAWalker2_validate;MirTarget;miRNATAP -0.159868765725503 0.00423117939816448 NA NA NA hsa-miR-330-5p FRAT2 1.44960468659754 2.12131210588035e-45 -0.49660955526236 6.4322474945319e-12 miRanda -0.183272005958233 9.61612894484404e-08 NA NA NA hsa-miR-340-5p FRAT2 1.14479851941741 2.91936881701444e-15 -0.49660955526236 6.4322474945319e-12 mirMAP -0.112937523465222 2.74807076074127e-05 NA NA NA hsa-miR-421 FRAT2 0.313155739887734 0.020433534776003 -0.49660955526236 6.4322474945319e-12 miRanda -0.119283601624292 0.000136365438460713 NA NA NA hsa-miR-200a-5p FZD1 -1.36295040293874 1.31587720312419e-22 1.18897996620487 6.40075199454189e-23 MirTarget -0.237303432841978 5.05545143933163e-07 NA NA NA hsa-miR-200b-5p FZD1 -1.46985752435972 3.43232443788022e-27 1.18897996620487 6.40075199454189e-23 MirTarget -0.284295772752584 2.28979329100603e-09 NA NA NA hsa-miR-29a-3p FZD1 -0.431613225927952 4.10166815070288e-08 1.18897996620487 6.40075199454189e-23 mirMAP -0.630692071690045 4.00733131833338e-13 NA NA NA hsa-miR-29b-3p FZD1 -0.228125979913806 0.0271621721891603 1.18897996620487 6.40075199454189e-23 mirMAP -0.344528946983843 4.88250386701375e-07 NA NA NA hsa-miR-29c-3p FZD1 -0.238671318446745 0.0141475322347596 1.18897996620487 6.40075199454189e-23 mirMAP -0.343764763499162 2.40176712567126e-06 NA NA NA hsa-miR-335-5p FZD1 -2.09515619961552 1.03765771499548e-25 1.18897996620487 6.40075199454189e-23 miRNAWalker2_validate -0.196968577894013 1.46544128662299e-09 NA NA NA hsa-miR-514a-3p FZD1 -3.60916038800272 7.44698991540685e-35 1.18897996620487 6.40075199454189e-23 MirTarget -0.11508280709999 8.81799422383285e-08 NA NA NA hsa-miR-577 FZD1 -1.48881999472397 7.03080165111147e-10 1.18897996620487 6.40075199454189e-23 MirTarget;PITA -0.124935867613655 1.28983332156977e-05 NA NA NA hsa-miR-107 FZD10 0.140046250553248 0.0943611632552367 -0.0105536578305034 0.964908170337496 miRanda -1.01467739461736 6.43538981376536e-11 NA NA NA hsa-miR-32-5p FZD10 0.407826130035097 7.26884631998646e-06 -0.0105536578305034 0.964908170337496 miRNATAP -0.494045091233897 0.000609923028418673 NA NA NA hsa-miR-455-3p FZD10 0.171798655137046 0.261841668213493 -0.0105536578305034 0.964908170337496 PITA;miRNATAP -0.396087264547542 3.65323026992865e-06 NA NA NA hsa-miR-98-5p FZD10 0.0569715596189075 0.450575962846765 -0.0105536578305034 0.964908170337496 miRNAWalker2_validate -0.795249061355186 6.24048869573494e-06 NA NA NA hsa-let-7b-5p FZD3 0.770868211539597 6.63408323707647e-21 -1.04311294572608 4.3896749999504e-25 MirTarget;miRNATAP -0.297267628507525 1.49550298428553e-05 NA NA NA hsa-let-7f-1-3p FZD3 0.477913872379336 4.46669616865068e-05 -1.04311294572608 4.3896749999504e-25 MirTarget -0.181784802640275 0.000960085987151416 NA NA NA hsa-let-7i-5p FZD3 0.911372377723717 7.11483853341932e-31 -1.04311294572608 4.3896749999504e-25 MirTarget;miRNATAP -0.262906938475552 0.000154654474446727 NA NA NA hsa-miR-103a-3p FZD3 0.779373475434461 7.37867196796994e-20 -1.04311294572608 4.3896749999504e-25 MirTarget -0.439796779902477 1.19874694107304e-11 NA NA NA hsa-miR-106b-5p FZD3 1.07509411417907 2.11739194181878e-36 -1.04311294572608 4.3896749999504e-25 MirTarget;mirMAP;miRNATAP -0.473520236033418 6.70573413605151e-15 NA NA NA hsa-miR-126-5p FZD3 0.785607261431085 5.77058629454465e-13 -1.04311294572608 4.3896749999504e-25 mirMAP -0.190812915606903 0.000327016170622135 NA NA NA hsa-miR-130b-3p FZD3 1.12788913578446 2.939369462276e-16 -1.04311294572608 4.3896749999504e-25 mirMAP -0.142779834574591 0.000579890288086553 NA NA NA hsa-miR-140-5p FZD3 0.504309496243674 3.09884038729031e-11 -1.04311294572608 4.3896749999504e-25 miRanda -0.351506784761809 4.83378523634811e-06 NA NA NA hsa-miR-142-3p FZD3 1.88928758773299 2.72985643829893e-22 -1.04311294572608 4.3896749999504e-25 miRanda -0.152723232142726 7.0877698230222e-08 NA NA NA hsa-miR-143-3p FZD3 0.544259011512089 1.71102635165867e-05 -1.04311294572608 4.3896749999504e-25 mirMAP -0.143529127901911 0.00223362387765262 NA NA NA hsa-miR-146a-5p FZD3 1.04938133739924 7.51013231709992e-12 -1.04311294572608 4.3896749999504e-25 MirTarget -0.195760662579759 1.6093331134118e-07 NA NA NA hsa-miR-155-5p FZD3 3.26274490570809 5.06841441826518e-51 -1.04311294572608 4.3896749999504e-25 mirMAP -0.190822068802253 1.59957216164852e-17 NA NA NA hsa-miR-16-1-3p FZD3 1.51429140700091 3.17219833254498e-37 -1.04311294572608 4.3896749999504e-25 mirMAP -0.268015971151015 2.24170345227388e-09 NA NA NA hsa-miR-16-2-3p FZD3 1.3046118743965 4.17207934608428e-19 -1.04311294572608 4.3896749999504e-25 mirMAP -0.205429840568988 7.71735410668427e-08 NA NA NA hsa-miR-17-5p FZD3 0.494260110870015 3.8348005261e-09 -1.04311294572608 4.3896749999504e-25 MirTarget;TargetScan;mirMAP;miRNATAP -0.184590941966793 0.00896721340153011 NA NA NA hsa-miR-181a-5p FZD3 1.11111114875339 3.97880443756442e-29 -1.04311294572608 4.3896749999504e-25 mirMAP -0.36590351075096 1.23522048878962e-11 NA NA NA hsa-miR-181b-5p FZD3 1.49054296272357 3.69051660739368e-41 -1.04311294572608 4.3896749999504e-25 mirMAP -0.341760147449408 1.12987877908813e-13 NA NA NA hsa-miR-186-5p FZD3 0.507217561043443 9.04455748270995e-10 -1.04311294572608 4.3896749999504e-25 mirMAP -0.188122997757206 0.00844970036487827 NA NA NA hsa-miR-19a-3p FZD3 0.722913586880779 2.76301458932381e-10 -1.04311294572608 4.3896749999504e-25 mirMAP -0.170280111877158 0.00085062903755598 NA NA NA hsa-miR-20a-5p FZD3 0.702602695798242 4.06372887613329e-13 -1.04311294572608 4.3896749999504e-25 MirTarget;mirMAP;miRNATAP -0.26614537443907 7.83474342254034e-06 NA NA NA hsa-miR-2355-3p FZD3 1.32757890426926 1.88016636795886e-18 -1.04311294572608 4.3896749999504e-25 mirMAP -0.145058213321557 0.00015535039636979 NA NA NA hsa-miR-23a-3p FZD3 0.761438723382355 4.09310879199257e-27 -1.04311294572608 4.3896749999504e-25 MirTarget -0.40556276482203 2.09127965855521e-07 NA NA NA hsa-miR-27a-3p FZD3 0.558934437526245 1.44256383086177e-12 -1.04311294572608 4.3896749999504e-25 miRNATAP -0.36071915288459 8.69667689642873e-07 NA NA NA hsa-miR-28-3p FZD3 1.01277915413238 1.8655970171461e-43 -1.04311294572608 4.3896749999504e-25 mirMAP -0.512278374058261 2.15217696855893e-13 NA NA NA hsa-miR-330-3p FZD3 0.912906550436308 3.35037014057665e-13 -1.04311294572608 4.3896749999504e-25 MirTarget;PITA;miRNATAP -0.176244411509209 0.0001775833510189 NA NA NA hsa-miR-338-3p FZD3 0.906250377628867 2.76970900371139e-15 -1.04311294572608 4.3896749999504e-25 PITA;miRanda -0.230562538359162 3.52727172858029e-06 NA NA NA hsa-miR-338-5p FZD3 0.628429807914222 1.27575140717947e-06 -1.04311294572608 4.3896749999504e-25 mirMAP -0.193416367939392 2.81863006033106e-05 NA NA NA hsa-miR-342-3p FZD3 1.4124432570595 1.07208971556131e-28 -1.04311294572608 4.3896749999504e-25 miRanda -0.213548558134392 5.83889280548379e-07 NA NA NA hsa-miR-374a-3p FZD3 1.13863935833993 2.79089304015401e-44 -1.04311294572608 4.3896749999504e-25 mirMAP -0.533949837747404 3.21209352596017e-18 NA NA NA hsa-miR-374a-5p FZD3 0.543061152108237 2.19403097299769e-14 -1.04311294572608 4.3896749999504e-25 mirMAP -0.518813184476156 9.44766833815146e-11 NA NA NA hsa-miR-374b-5p FZD3 0.0804104684417872 0.365593963035077 -1.04311294572608 4.3896749999504e-25 mirMAP -0.187522547562267 0.00604836097855249 NA NA NA hsa-miR-452-3p FZD3 1.72039996672257 1.35748079442153e-22 -1.04311294572608 4.3896749999504e-25 MirTarget -0.158706998343871 7.72548940529983e-07 NA NA NA hsa-miR-452-5p FZD3 2.05325688842141 2.82238393643084e-40 -1.04311294572608 4.3896749999504e-25 mirMAP -0.247182958968441 6.96496325447191e-14 NA NA NA hsa-miR-454-3p FZD3 0.68285296887698 1.17407812677787e-08 -1.04311294572608 4.3896749999504e-25 mirMAP -0.128805658384015 0.00889687462362434 NA NA NA hsa-miR-590-3p FZD3 1.13702599385212 3.53435739887793e-22 -1.04311294572608 4.3896749999504e-25 miRanda;mirMAP;miRNATAP -0.22571834463035 1.99847968139135e-06 NA NA NA hsa-miR-625-3p FZD3 1.09679549288964 4.60800634006165e-20 -1.04311294572608 4.3896749999504e-25 mirMAP -0.169603485564342 0.000328022052507216 NA NA NA hsa-miR-629-5p FZD3 1.73389921851483 5.39614356468007e-48 -1.04311294572608 4.3896749999504e-25 MirTarget -0.28509682096437 1.43667036293409e-11 NA NA NA hsa-miR-7-1-3p FZD3 0.544601828025304 5.33830451326047e-07 -1.04311294572608 4.3896749999504e-25 mirMAP -0.1474047023299 0.00697865454508537 NA NA NA hsa-miR-93-5p FZD3 1.37365940377595 2.37567548683245e-46 -1.04311294572608 4.3896749999504e-25 MirTarget;mirMAP;miRNATAP -0.39312109889616 5.716812231823e-14 NA NA NA hsa-miR-10a-5p FZD4 -1.17164272592931 4.86621098042279e-24 0.458457429096661 1.45681215340493e-05 MirTarget -0.135574203047511 0.00424899578871124 NA NA NA hsa-miR-125b-5p FZD4 -0.825456421494266 2.13029877878434e-15 0.458457429096661 1.45681215340493e-05 miRNAWalker2_validate -0.144600660127576 0.00796821817804433 NA NA NA hsa-miR-132-3p FZD4 0.291409674711894 0.000912684337101876 0.458457429096661 1.45681215340493e-05 mirMAP -0.313066475215544 2.58848789609525e-06 NA NA NA hsa-miR-199b-5p FZD4 -2.39483476763681 1.04659509514884e-17 0.458457429096661 1.45681215340493e-05 MirTarget;PITA;miRanda;miRNATAP -0.105604879579982 1.60106567131654e-07 NA NA NA hsa-miR-200b-3p FZD4 -1.70383252137161 2.38979336321755e-30 0.458457429096661 1.45681215340493e-05 mirMAP -0.111830163416284 0.00190816196717208 NA NA NA hsa-miR-212-3p FZD4 0.140490094813501 0.298248972687012 0.458457429096661 1.45681215340493e-05 mirMAP -0.139553058446201 0.00155018292855188 NA NA NA hsa-miR-22-5p FZD4 -0.197038086012602 0.106234828461117 0.458457429096661 1.45681215340493e-05 mirMAP -0.187016958866808 0.000106227572900588 NA NA NA hsa-miR-589-3p FZD4 -0.0184909376114044 0.903149951095234 0.458457429096661 1.45681215340493e-05 mirMAP -0.140960018589024 0.000362867225129375 NA NA NA hsa-miR-92b-3p FZD4 0.418630595140165 6.50466149211154e-05 0.458457429096661 1.45681215340493e-05 mirMAP -0.201633069493349 0.000301326558594845 NA NA NA hsa-miR-149-5p FZD5 -1.95790336710741 8.46371715052367e-27 0.583650554484417 1.47306695584846e-06 miRNAWalker2_validate;miRNATAP -0.195535517950565 5.59711687641786e-09 NA NA NA hsa-miR-335-3p FZD5 -1.36498175550207 6.84287752180534e-13 0.583650554484417 1.47306695584846e-06 MirTarget;mirMAP -0.154808826706275 5.71962463751601e-06 NA NA NA hsa-let-7a-3p FZD6 0.0677487960013088 0.460458477653989 -0.713547911934427 4.6402947278289e-14 MirTarget;mirMAP -0.218394082029521 0.000241194213279582 NA NA NA hsa-let-7f-1-3p FZD6 0.477913872379336 4.46669616865068e-05 -0.713547911934427 4.6402947278289e-14 MirTarget;mirMAP -0.203755820988442 3.90477399842581e-05 NA NA NA hsa-miR-101-3p FZD6 0.683973909682285 2.88573524246948e-15 -0.713547911934427 4.6402947278289e-14 miRNAWalker2_validate;MirTarget -0.492555382183418 1.12231291794818e-17 NA NA NA hsa-miR-107 FZD6 0.140046250553248 0.0943611632552367 -0.713547911934427 4.6402947278289e-14 miRanda -0.366761211433128 1.18353924890157e-08 NA NA NA hsa-miR-126-5p FZD6 0.785607261431085 5.77058629454465e-13 -0.713547911934427 4.6402947278289e-14 mirMAP;miRNATAP -0.16688559425803 0.000513078757809893 NA NA NA hsa-miR-130b-3p FZD6 1.12788913578446 2.939369462276e-16 -0.713547911934427 4.6402947278289e-14 MirTarget -0.127564853523286 0.000674035276870961 NA NA NA hsa-miR-140-5p FZD6 0.504309496243674 3.09884038729031e-11 -0.713547911934427 4.6402947278289e-14 MirTarget;miRanda -0.181823097770399 0.00966291980828589 NA NA NA hsa-miR-144-3p FZD6 1.4617706700291 9.18139413836375e-11 -0.713547911934427 4.6402947278289e-14 MirTarget -0.105585982487327 5.0418483078103e-06 NA NA NA hsa-miR-194-5p FZD6 0.62222617402691 0.00659826803316099 -0.713547911934427 4.6402947278289e-14 MirTarget -0.196314924199211 1.75605555280948e-18 NA NA NA hsa-miR-19a-3p FZD6 0.722913586880779 2.76301458932381e-10 -0.713547911934427 4.6402947278289e-14 MirTarget -0.143881568742793 0.00184229786276554 NA NA NA hsa-miR-342-3p FZD6 1.4124432570595 1.07208971556131e-28 -0.713547911934427 4.6402947278289e-14 miRanda -0.198359086540678 2.75262859196131e-07 NA NA NA hsa-miR-455-5p FZD6 0.773674551205946 2.12957541541474e-09 -0.713547911934427 4.6402947278289e-14 miRanda -0.303740205385634 1.47557989051135e-14 NA NA NA hsa-miR-590-3p FZD6 1.13702599385212 3.53435739887793e-22 -0.713547911934427 4.6402947278289e-14 MirTarget;PITA;miRanda;mirMAP -0.173708996665933 5.64760519619443e-05 NA NA NA hsa-miR-590-5p FZD6 0.709763558412506 1.11883921359361e-11 -0.713547911934427 4.6402947278289e-14 PITA;miRanda -0.175146230138535 0.000505674605027954 NA NA NA hsa-miR-106b-5p FZD7 1.07509411417907 2.11739194181878e-36 -1.04844010704488 5.51861670571538e-18 miRNATAP -0.499535768578559 4.41278638982439e-12 NA NA NA hsa-miR-130b-5p FZD7 0.92990617673277 3.75880436852717e-12 -1.04844010704488 5.51861670571538e-18 mirMAP -0.185021595310988 0.000273467933484435 NA NA NA hsa-miR-142-3p FZD7 1.88928758773299 2.72985643829893e-22 -1.04844010704488 5.51861670571538e-18 miRanda -0.130459044700555 0.000107194209018149 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7; In addition we demonstrated that FZD7 was a direct target of miR-142-3p by dual luciferase assay and Western blot analysis; Overexpression of FZD7 expression was able to reverse the inhibitory effects induced by miR-142-3p cervical and endocervical cancer hsa-miR-142-5p FZD7 1.88417391525707 1.2096808039882e-27 -1.04844010704488 5.51861670571538e-18 MirTarget;PITA;miRNATAP -0.179999492386373 1.14904045606403e-06 25976503 MicroRNA 142 3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7 cervical and endocervical cancer hsa-miR-186-5p FZD7 0.507217561043443 9.04455748270995e-10 -1.04844010704488 5.51861670571538e-18 mirMAP -0.351888110196916 2.3860888672338e-05 NA NA NA hsa-miR-20a-5p FZD7 0.702602695798242 4.06372887613329e-13 -1.04844010704488 5.51861670571538e-18 miRNATAP -0.324563062850531 3.4537039190343e-06 NA NA NA hsa-miR-2355-5p FZD7 1.57515081110162 3.54962327490702e-48 -1.04844010704488 5.51861670571538e-18 MirTarget -0.304454010614901 3.91408050938596e-08 NA NA NA hsa-miR-27a-3p FZD7 0.558934437526245 1.44256383086177e-12 -1.04844010704488 5.51861670571538e-18 MirTarget;miRNATAP -0.227411027336672 0.00924773653023277 24018051 Moreover up-regulation of miR-27a did not decrease the FZD7 mRNA level but significantly reduce its protein expression in BEL/5-FU cells; It was also confirmed that reduction of FZD7 by RNA interference induced inhibitory effects on the expression of MDR1/P-glycoprotein and β-catenin similar to miR-27a liver cancer hsa-miR-330-3p FZD7 0.912906550436308 3.35037014057665e-13 -1.04844010704488 5.51861670571538e-18 mirMAP -0.308419059049457 1.53866733934032e-08 NA NA NA hsa-miR-486-5p FZD7 1.16748143760361 1.68410465883829e-08 -1.04844010704488 5.51861670571538e-18 miRanda -0.101124145271838 0.00239209711612664 NA NA NA hsa-miR-590-3p FZD7 1.13702599385212 3.53435739887793e-22 -1.04844010704488 5.51861670571538e-18 miRanda -0.259592153900114 3.37650758938895e-06 NA NA NA hsa-miR-616-5p FZD7 0.913426384742148 3.78418389333709e-09 -1.04844010704488 5.51861670571538e-18 mirMAP -0.157498116643287 0.000476353438254426 NA NA NA hsa-miR-181a-5p GSK3B 1.11111114875339 3.97880443756442e-29 -0.228723498264944 0.000365732006378195 mirMAP -0.111663336693774 0.0006569391284283 NA NA NA hsa-miR-181b-5p GSK3B 1.49054296272357 3.69051660739368e-41 -0.228723498264944 0.000365732006378195 mirMAP -0.112111617296075 6.37240999540997e-05 NA NA NA hsa-miR-18a-5p GSK3B 0.936704393213466 1.05064580570579e-10 -0.228723498264944 0.000365732006378195 miRNATAP -0.129655229012053 2.96928927454631e-08 NA NA NA hsa-miR-19a-3p GSK3B 0.722913586880779 2.76301458932381e-10 -0.228723498264944 0.000365732006378195 mirMAP -0.128885925042799 1.75451278817822e-05 NA NA NA hsa-miR-19b-3p GSK3B 0.195940928879427 0.0300512922542325 -0.228723498264944 0.000365732006378195 mirMAP -0.147506705421778 0.000182148718420472 NA NA NA hsa-miR-26b-5p GSK3B -0.251437253429904 0.00270935785098697 -0.228723498264944 0.000365732006378195 miRNATAP -0.153051347819886 0.000309841684251065 NA NA NA hsa-miR-27a-3p GSK3B 0.558934437526245 1.44256383086177e-12 -0.228723498264944 0.000365732006378195 miRNATAP -0.194470247735897 7.8023921113285e-06 NA NA NA hsa-miR-590-3p GSK3B 1.13702599385212 3.53435739887793e-22 -0.228723498264944 0.000365732006378195 miRanda;miRNATAP -0.108155182029881 0.000128807781068845 NA NA NA hsa-miR-30a-5p JUN -0.778411951775343 2.73322451127932e-16 0.299129375328292 0.0179949924502712 miRNAWalker2_validate -0.220689109507382 0.00170903222537552 NA NA NA hsa-miR-107 LEF1 0.140046250553248 0.0943611632552367 0.418404112804963 0.0253732275048255 miRanda -0.350799889230692 0.00496598986390596 NA NA NA hsa-miR-3065-3p LEF1 -1.64500070417457 9.57561660036697e-16 0.418404112804963 0.0253732275048255 miRNATAP -0.295694386150053 3.16655103786743e-10 NA NA NA hsa-miR-455-5p LEF1 0.773674551205946 2.12957541541474e-09 0.418404112804963 0.0253732275048255 miRanda -0.435515986434238 1.42370060375117e-08 NA NA NA hsa-miR-501-5p LEF1 -1.1103073934745 1.81589804886553e-16 0.418404112804963 0.0253732275048255 PITA;miRNATAP -0.261357099364367 0.00033612990039779 NA NA NA hsa-miR-148a-5p LRP6 0.415500302855613 0.000691460831436767 -0.826926364918593 5.02972180857964e-18 mirMAP -0.217413406371658 1.13685231470903e-06 NA NA NA hsa-miR-15a-5p LRP6 1.42663930007845 1.36006952074963e-57 -0.826926364918593 5.02972180857964e-18 miRNATAP -0.388863906008959 1.0689487866007e-14 NA NA NA hsa-miR-15b-3p LRP6 1.49422666971434 5.44139893275088e-29 -0.826926364918593 5.02972180857964e-18 mirMAP -0.279798879887785 2.33539685690718e-14 NA NA NA hsa-miR-15b-5p LRP6 0.773001494057531 1.71784656078957e-16 -0.826926364918593 5.02972180857964e-18 miRNATAP -0.334975295142436 1.68690848516097e-09 NA NA NA hsa-miR-16-1-3p LRP6 1.51429140700091 3.17219833254498e-37 -0.826926364918593 5.02972180857964e-18 mirMAP -0.252042501559752 1.19221680380673e-09 NA NA NA hsa-miR-16-2-3p LRP6 1.3046118743965 4.17207934608428e-19 -0.826926364918593 5.02972180857964e-18 mirMAP -0.252227366613689 3.91200305794031e-13 NA NA NA hsa-miR-16-5p LRP6 0.934012514027655 4.85417898318515e-24 -0.826926364918593 5.02972180857964e-18 miRNATAP -0.303692786399207 4.01917776689201e-08 NA NA NA hsa-miR-17-5p LRP6 0.494260110870015 3.8348005261e-09 -0.826926364918593 5.02972180857964e-18 mirMAP -0.226866016037653 0.000492857770370124 NA NA NA hsa-miR-181a-5p LRP6 1.11111114875339 3.97880443756442e-29 -0.826926364918593 5.02972180857964e-18 mirMAP -0.156718371492991 0.00229148867809766 NA NA NA hsa-miR-181b-5p LRP6 1.49054296272357 3.69051660739368e-41 -0.826926364918593 5.02972180857964e-18 mirMAP -0.222662598583022 3.16334210026338e-07 NA NA NA hsa-miR-186-5p LRP6 0.507217561043443 9.04455748270995e-10 -0.826926364918593 5.02972180857964e-18 mirMAP -0.324252788490113 6.62459174713589e-07 NA NA NA hsa-miR-193a-3p LRP6 0.849206638484406 3.68101781083335e-14 -0.826926364918593 5.02972180857964e-18 miRanda -0.33523134863113 4.16824898341212e-13 NA NA NA hsa-miR-195-5p LRP6 0.346502644882604 0.0092562828415903 -0.826926364918593 5.02972180857964e-18 miRNATAP -0.116790814022786 0.0051015793097807 NA NA NA hsa-miR-20a-5p LRP6 0.702602695798242 4.06372887613329e-13 -0.826926364918593 5.02972180857964e-18 mirMAP -0.197763210999318 0.000358643998567802 NA NA NA hsa-miR-221-3p LRP6 0.337895669520713 0.0136448974691037 -0.826926364918593 5.02972180857964e-18 miRNAWalker2_validate -0.192042334629386 1.64803142407895e-06 NA NA NA hsa-miR-29b-3p LRP6 -0.228125979913806 0.0271621721891603 -0.826926364918593 5.02972180857964e-18 miRNATAP -0.262940465357632 8.37279704987294e-07 NA NA NA hsa-miR-330-3p LRP6 0.912906550436308 3.35037014057665e-13 -0.826926364918593 5.02972180857964e-18 PITA;mirMAP;miRNATAP -0.158322204130854 0.000276321465883742 NA NA NA hsa-miR-590-3p LRP6 1.13702599385212 3.53435739887793e-22 -0.826926364918593 5.02972180857964e-18 PITA;miRanda;miRNATAP -0.302958718037242 1.97653685325731e-12 NA NA NA hsa-miR-590-5p LRP6 0.709763558412506 1.11883921359361e-11 -0.826926364918593 5.02972180857964e-18 PITA;miRanda;miRNATAP -0.296086850597523 5.22007795211323e-09 NA NA NA hsa-miR-616-5p LRP6 0.913426384742148 3.78418389333709e-09 -0.826926364918593 5.02972180857964e-18 mirMAP -0.131239603917925 0.000213481752213534 NA NA NA hsa-miR-671-5p LRP6 0.740296481994777 8.07053661008188e-07 -0.826926364918593 5.02972180857964e-18 PITA -0.239334579573558 2.54324384797078e-11 NA NA NA hsa-miR-7-1-3p LRP6 0.544601828025304 5.33830451326047e-07 -0.826926364918593 5.02972180857964e-18 mirMAP -0.147254785411101 0.00355866479021224 NA NA NA hsa-miR-93-5p LRP6 1.37365940377595 2.37567548683245e-46 -0.826926364918593 5.02972180857964e-18 mirMAP -0.342503755429646 1.96217170048513e-12 NA NA NA hsa-miR-130b-3p MAPK10 1.12788913578446 2.939369462276e-16 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.426865766422543 6.2125228747084e-24 NA NA NA hsa-miR-146b-5p MAPK10 1.40714170253819 2.9559871816487e-12 -1.21487132791135 4.28083849239698e-29 miRanda -0.238154498396656 2.40916717729571e-15 NA NA NA hsa-miR-193a-3p MAPK10 0.849206638484406 3.68101781083335e-14 -1.21487132791135 4.28083849239698e-29 miRanda;miRNATAP -0.477791684724428 3.60529507654292e-19 NA NA NA hsa-miR-19a-3p MAPK10 0.722913586880779 2.76301458932381e-10 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.350806870796812 1.13510508025726e-10 NA NA NA hsa-miR-19b-3p MAPK10 0.195940928879427 0.0300512922542325 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.309366846213377 1.96850100098747e-05 NA NA NA hsa-miR-221-3p MAPK10 0.337895669520713 0.0136448974691037 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.257156072087272 4.41278059795946e-08 NA NA NA hsa-miR-222-3p MAPK10 0.214811008033524 0.0965295551752457 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.299797013226272 1.63347653838624e-09 NA NA NA hsa-miR-29b-3p MAPK10 -0.228125979913806 0.0271621721891603 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.196078455627514 0.00205832566182426 24767251 The percentage of positive myeloid cell leukemia sequence 1 ATG9A and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer; Univariate Kaplan-Meier analysis showed a negative correlation between MAPK10 or ATG9A protein expression and overall as well as progression-free survival whereas a positive correlation was observed between miR-29b mRNA expression and overall as well as progression-free survival; Multivariate Cox regression analysis showed that elevated MAPK10 or ATG9A protein and lowered miR-29b mRNA expression in ovarian carcinoma was an independent poor prognostic predictor; Our study suggested that miR-29b mRNA MAPK10 protein expression and ATG9A protein expression are closely related to chemosensitivity of ovarian carcinoma staging;progression;poor survival ovarian cancer hsa-miR-301a-3p MAPK10 0.259400847075798 0.0216890736701418 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.206875912734593 0.000352634513303849 NA NA NA hsa-miR-330-3p MAPK10 0.912906550436308 3.35037014057665e-13 -1.21487132791135 4.28083849239698e-29 PITA;miRNATAP -0.23056537801525 6.24801819994022e-06 NA NA NA hsa-miR-454-3p MAPK10 0.68285296887698 1.17407812677787e-08 -1.21487132791135 4.28083849239698e-29 miRNATAP -0.340810695000248 7.01951489670639e-11 NA NA NA hsa-miR-590-3p MAPK10 1.13702599385212 3.53435739887793e-22 -1.21487132791135 4.28083849239698e-29 miRanda;mirMAP -0.400723704396593 1.46142734104843e-15 NA NA NA hsa-miR-590-5p MAPK10 0.709763558412506 1.11883921359361e-11 -1.21487132791135 4.28083849239698e-29 PITA;miRanda;miRNATAP -0.384956181913074 9.15169986554425e-11 NA NA NA hsa-let-7a-3p MAPK8 0.0677487960013088 0.460458477653989 -0.750160075359857 1.06943990640368e-11 mirMAP -0.224745732614521 0.00113114965599641 NA NA NA hsa-let-7f-1-3p MAPK8 0.477913872379336 4.46669616865068e-05 -0.750160075359857 1.06943990640368e-11 mirMAP -0.198193629510422 0.000578100841933834 NA NA NA hsa-miR-130b-3p MAPK8 1.12788913578446 2.939369462276e-16 -0.750160075359857 1.06943990640368e-11 mirMAP -0.300046383602671 1.12283314104074e-12 NA NA NA hsa-miR-140-3p MAPK8 0.989350547007025 6.14964028267239e-25 -0.750160075359857 1.06943990640368e-11 miRNAWalker2_validate -0.21607071391855 0.000381512783937793 NA NA NA hsa-miR-16-2-3p MAPK8 1.3046118743965 4.17207934608428e-19 -0.750160075359857 1.06943990640368e-11 mirMAP -0.230603960728852 7.35216005494181e-09 NA NA NA hsa-miR-193b-3p MAPK8 -0.273325765316079 0.104328826585392 -0.750160075359857 1.06943990640368e-11 miRNAWalker2_validate -0.115617600028936 0.00194240080077243 NA NA NA hsa-miR-22-5p MAPK8 -0.197038086012602 0.106234828461117 -0.750160075359857 1.06943990640368e-11 mirMAP -0.269908296695586 1.14728279558826e-07 NA NA NA hsa-miR-374a-3p MAPK8 1.13863935833993 2.79089304015401e-44 -0.750160075359857 1.06943990640368e-11 mirMAP -0.289709574010348 1.55055266358389e-05 NA NA NA hsa-miR-590-3p MAPK8 1.13702599385212 3.53435739887793e-22 -0.750160075359857 1.06943990640368e-11 miRNATAP -0.262993606467664 1.07257214255814e-07 NA NA NA hsa-miR-24-3p MAPK9 0.173813044685099 0.00565259443420961 0.14417034408476 0.00521298953478229 miRNATAP -0.189071350720719 3.44779387721655e-05 NA NA NA hsa-miR-27b-3p MAPK9 -0.699527231242518 1.07356023759234e-15 0.14417034408476 0.00521298953478229 miRNAWalker2_validate -0.147750560718002 1.80817169396102e-06 NA NA NA hsa-miR-126-3p MMP7 0.5342810966167 1.97593747290509e-05 -1.88636701730958 2.95920274174608e-08 miRNAWalker2_validate -0.735144876665138 9.54244152967744e-07 NA NA NA hsa-miR-126-5p MMP7 0.785607261431085 5.77058629454465e-13 -1.88636701730958 2.95920274174608e-08 miRNAWalker2_validate -0.76498408363255 5.75379782527177e-06 NA NA NA hsa-miR-455-5p MMP7 0.773674551205946 2.12957541541474e-09 -1.88636701730958 2.95920274174608e-08 miRanda -0.76408024362453 8.85420847559681e-08 NA NA NA hsa-miR-542-3p MMP7 0.431147917094433 0.000254981247606435 -1.88636701730958 2.95920274174608e-08 miRanda -0.446766545542492 0.00583186349108826 NA NA NA hsa-miR-590-5p MMP7 0.709763558412506 1.11883921359361e-11 -1.88636701730958 2.95920274174608e-08 miRanda -0.491843267482964 0.00588952296901256 NA NA NA hsa-let-7g-5p MYC -0.739744008507763 1.07979566264383e-14 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate;miRTarBase -0.398905767136213 2.71236287032834e-05 NA NA NA hsa-miR-135a-5p MYC -2.13422485001223 6.29449029671498e-14 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.108827259333515 0.000903589484065675 23176581 Moreover based on the results of this analysis we investigated whether miR-135a targeted the c-MYC gene in RCC; Gain-of-function and luciferase reporter assays showed that c-MYC was directly regulated by miR-135a in RCC cells kidney renal cell cancer hsa-miR-335-5p MYC -2.09515619961552 1.03765771499548e-25 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.216426299788151 7.62566723121896e-07 NA NA NA hsa-miR-429 MYC -2.16569233119434 2.66862243626443e-37 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.389721783902253 2.72292816859272e-16 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-744-5p MYC -0.348985243196771 0.000187889982228835 1.69954133129988 7.75526107259408e-27 miRNAWalker2_validate -0.377458526504721 0.000190443255959769 24991193 Decrease expression of microRNA 744 promotes cell proliferation by targeting c Myc in human hepatocellular carcinoma; Quantitative reverse-transcription polymerase chain reaction qRT-PCR was conducted to detect the expression of miR-744 and Immunohistochemistry was performed to detect expression of c-Myc in HCC specimens and adjacent normal tissues; Luciferase reporter assays was performed to confirm whether miR-744 regulated the expression of c-Myc; Luciferase assay and Western blot analysis revealed that c-Myc is a direct target of miR-744; Down-regulation of miR-744 and up-regulation of c-Myc were detected in HCC specimens compared with adjacent normal tissues; Moreover restoration of miR-744 rescues c-Myc induced HCC proliferation; Our data suggest that miR-744 exerts its tumor suppressor function by targeting c-Myc leading to the inhibition of HCC cell growth liver cancer hsa-let-7a-3p NFAT5 0.0677487960013088 0.460458477653989 -0.816417557443788 1.77196856943782e-22 MirTarget;mirMAP;miRNATAP -0.251122459345359 2.99362459623734e-06 NA NA NA hsa-let-7b-3p NFAT5 0.239865279324672 0.00721479815526816 -0.816417557443788 1.77196856943782e-22 MirTarget;mirMAP;miRNATAP -0.167290657433056 0.00260582166238805 NA NA NA hsa-let-7f-1-3p NFAT5 0.477913872379336 4.46669616865068e-05 -0.816417557443788 1.77196856943782e-22 MirTarget;mirMAP -0.162111636601771 0.000334878272705912 NA NA NA hsa-miR-103a-3p NFAT5 0.779373475434461 7.37867196796994e-20 -0.816417557443788 1.77196856943782e-22 MirTarget -0.226989037620136 3.12029996215114e-05 NA NA NA hsa-miR-106b-5p NFAT5 1.07509411417907 2.11739194181878e-36 -0.816417557443788 1.77196856943782e-22 MirTarget;miRNATAP -0.473958453484205 2.37145177462699e-22 NA NA NA hsa-miR-107 NFAT5 0.140046250553248 0.0943611632552367 -0.816417557443788 1.77196856943782e-22 MirTarget -0.284279553198954 1.39825835957285e-06 NA NA NA hsa-miR-126-5p NFAT5 0.785607261431085 5.77058629454465e-13 -0.816417557443788 1.77196856943782e-22 MirTarget;mirMAP -0.185794566529228 1.93464514188037e-05 NA NA NA hsa-miR-1301-3p NFAT5 0.393537638993954 0.000390498879474539 -0.816417557443788 1.77196856943782e-22 MirTarget -0.15730957058684 0.000372298957721443 NA NA NA hsa-miR-130b-5p NFAT5 0.92990617673277 3.75880436852717e-12 -0.816417557443788 1.77196856943782e-22 MirTarget;miRNATAP -0.184769053016558 1.48889372928322e-07 NA NA NA hsa-miR-140-3p NFAT5 0.989350547007025 6.14964028267239e-25 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.22534520719281 2.00395668536591e-06 NA NA NA hsa-miR-140-5p NFAT5 0.504309496243674 3.09884038729031e-11 -0.816417557443788 1.77196856943782e-22 PITA;miRNATAP -0.347476077539168 3.06412649638075e-08 NA NA NA hsa-miR-142-5p NFAT5 1.88417391525707 1.2096808039882e-27 -0.816417557443788 1.77196856943782e-22 MirTarget;PITA;miRNATAP -0.200162187507738 1.57471676590964e-15 NA NA NA hsa-miR-143-3p NFAT5 0.544259011512089 1.71102635165867e-05 -0.816417557443788 1.77196856943782e-22 mirMAP -0.156816553769716 4.39791329926318e-05 NA NA NA hsa-miR-146a-5p NFAT5 1.04938133739924 7.51013231709992e-12 -0.816417557443788 1.77196856943782e-22 mirMAP;miRNATAP -0.179867398396589 3.92525390180619e-09 NA NA NA hsa-miR-146b-5p NFAT5 1.40714170253819 2.9559871816487e-12 -0.816417557443788 1.77196856943782e-22 miRanda -0.11829487162396 3.88354455444422e-07 NA NA NA hsa-miR-148a-3p NFAT5 0.343233211643815 0.00402279073598165 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.124866592482946 0.00250376588029971 NA NA NA hsa-miR-148a-5p NFAT5 0.415500302855613 0.000691460831436767 -0.816417557443788 1.77196856943782e-22 mirMAP -0.154809758528918 0.00010684880006692 NA NA NA hsa-miR-148b-3p NFAT5 0.346011252093377 4.27203463315056e-06 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.301816477855443 3.32125256428072e-06 NA NA NA hsa-miR-148b-5p NFAT5 0.269550343699955 0.0383631776794927 -0.816417557443788 1.77196856943782e-22 MirTarget -0.115797102716895 0.00310729655100489 NA NA NA hsa-miR-155-5p NFAT5 3.26274490570809 5.06841441826518e-51 -0.816417557443788 1.77196856943782e-22 mirMAP;miRNATAP -0.153399914764272 9.76022207199999e-17 NA NA NA hsa-miR-15a-5p NFAT5 1.42663930007845 1.36006952074963e-57 -0.816417557443788 1.77196856943782e-22 MirTarget -0.377473568207057 1.47515697050257e-17 NA NA NA hsa-miR-15b-3p NFAT5 1.49422666971434 5.44139893275088e-29 -0.816417557443788 1.77196856943782e-22 mirMAP -0.202041971607595 1.02875661648307e-09 NA NA NA hsa-miR-15b-5p NFAT5 0.773001494057531 1.71784656078957e-16 -0.816417557443788 1.77196856943782e-22 MirTarget -0.241136198150107 1.33553078102364e-06 NA NA NA hsa-miR-16-1-3p NFAT5 1.51429140700091 3.17219833254498e-37 -0.816417557443788 1.77196856943782e-22 mirMAP -0.289416940061869 1.02439287328607e-15 NA NA NA hsa-miR-16-5p NFAT5 0.934012514027655 4.85417898318515e-24 -0.816417557443788 1.77196856943782e-22 MirTarget -0.337389066839677 3.37727375245208e-12 NA NA NA hsa-miR-17-3p NFAT5 0.723795600017259 5.90151677164931e-18 -0.816417557443788 1.77196856943782e-22 mirMAP -0.344914443640037 3.62091701501056e-10 NA NA NA hsa-miR-17-5p NFAT5 0.494260110870015 3.8348005261e-09 -0.816417557443788 1.77196856943782e-22 miRNAWalker2_validate;MirTarget;TargetScan;miRNATAP -0.181859753330541 0.00169749612389596 NA NA NA hsa-miR-181a-5p NFAT5 1.11111114875339 3.97880443756442e-29 -0.816417557443788 1.77196856943782e-22 MirTarget;miRNATAP -0.305771219565393 5.37612109782185e-12 NA NA NA hsa-miR-181b-5p NFAT5 1.49054296272357 3.69051660739368e-41 -0.816417557443788 1.77196856943782e-22 MirTarget;miRNATAP -0.302060455365795 9.12597853838058e-16 NA NA NA hsa-miR-186-5p NFAT5 0.507217561043443 9.04455748270995e-10 -0.816417557443788 1.77196856943782e-22 MirTarget;mirMAP -0.324285678163902 1.83640270733673e-08 NA NA NA hsa-miR-18a-5p NFAT5 0.936704393213466 1.05064580570579e-10 -0.816417557443788 1.77196856943782e-22 MirTarget;miRNATAP -0.19721332602987 1.10729342588133e-09 NA NA NA hsa-miR-192-3p NFAT5 0.156650099616707 0.483496040900362 -0.816417557443788 1.77196856943782e-22 MirTarget;miRNATAP -0.136876762351209 2.7601666180186e-10 NA NA NA hsa-miR-193a-3p NFAT5 0.849206638484406 3.68101781083335e-14 -0.816417557443788 1.77196856943782e-22 miRanda -0.278691847393094 1.49487135428537e-11 NA NA NA hsa-miR-194-3p NFAT5 -0.0573594560647068 0.802137112420482 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.101670396908308 2.58594992886226e-06 NA NA NA hsa-miR-194-5p NFAT5 0.62222617402691 0.00659826803316099 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.146005298470987 2.11910566216041e-12 NA NA NA hsa-miR-195-5p NFAT5 0.346502644882604 0.0092562828415903 -0.816417557443788 1.77196856943782e-22 MirTarget -0.218378711497831 1.70435974528423e-09 NA NA NA hsa-miR-21-3p NFAT5 1.78837590049697 1.41655409877312e-33 -0.816417557443788 1.77196856943782e-22 MirTarget -0.212553530979547 2.31677756321625e-13 NA NA NA hsa-miR-21-5p NFAT5 2.51462371613332 3.30620591950316e-66 -0.816417557443788 1.77196856943782e-22 miRNAWalker2_validate;mirMAP -0.247574654543565 7.30559064815237e-22 NA NA NA hsa-miR-224-3p NFAT5 0.918780460857403 2.47005991706282e-07 -0.816417557443788 1.77196856943782e-22 MirTarget -0.112701920966496 5.73626394651817e-05 NA NA NA hsa-miR-224-5p NFAT5 2.84654230414912 3.0480927226395e-47 -0.816417557443788 1.77196856943782e-22 mirMAP -0.135061426543241 1.30762168213107e-10 NA NA NA hsa-miR-2355-3p NFAT5 1.32757890426926 1.88016636795886e-18 -0.816417557443788 1.77196856943782e-22 MirTarget;miRNATAP -0.277842795160608 1.35617318456645e-20 NA NA NA hsa-miR-24-3p NFAT5 0.173813044685099 0.00565259443420961 -0.816417557443788 1.77196856943782e-22 miRNAWalker2_validate;miRNATAP -0.401575492208128 3.65723516019206e-07 NA NA NA hsa-miR-25-3p NFAT5 1.12016166564779 3.79069348635778e-48 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.37542832851899 3.84349761814913e-12 NA NA NA hsa-miR-27a-3p NFAT5 0.558934437526245 1.44256383086177e-12 -0.816417557443788 1.77196856943782e-22 MirTarget -0.420842515213438 1.06725145991906e-12 NA NA NA hsa-miR-32-5p NFAT5 0.407826130035097 7.26884631998646e-06 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.341493954955972 8.82645473577493e-11 NA NA NA hsa-miR-320b NFAT5 0.300497419754843 0.0245219177384172 -0.816417557443788 1.77196856943782e-22 mirMAP -0.119456848415258 0.0012026595083638 NA NA NA hsa-miR-330-3p NFAT5 0.912906550436308 3.35037014057665e-13 -0.816417557443788 1.77196856943782e-22 mirMAP -0.191703168315778 5.69686462366241e-07 NA NA NA hsa-miR-338-5p NFAT5 0.628429807914222 1.27575140717947e-06 -0.816417557443788 1.77196856943782e-22 MirTarget;PITA;mirMAP -0.180783044531869 1.75462074277193e-06 NA NA NA hsa-miR-340-5p NFAT5 1.14479851941741 2.91936881701444e-15 -0.816417557443788 1.77196856943782e-22 MirTarget -0.178489695723996 2.48056825351363e-08 NA NA NA hsa-miR-361-3p NFAT5 1.08992546227594 1.13197240706704e-36 -0.816417557443788 1.77196856943782e-22 MirTarget;PITA;miRNATAP -0.384654962985852 7.2743816956711e-15 NA NA NA hsa-miR-361-5p NFAT5 0.0514169367202078 0.382929376393199 -0.816417557443788 1.77196856943782e-22 MirTarget;PITA;mirMAP;miRNATAP -0.284458777474624 0.000927918191242783 NA NA NA hsa-miR-3613-5p NFAT5 1.6648190889407 3.78720979041391e-41 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.312076764221362 6.11347179992732e-21 NA NA NA hsa-miR-365a-3p NFAT5 0.80809616164259 2.36039522526e-12 -0.816417557443788 1.77196856943782e-22 MirTarget -0.168480254138622 4.3973023269716e-05 NA NA NA hsa-miR-374a-3p NFAT5 1.13863935833993 2.79089304015401e-44 -0.816417557443788 1.77196856943782e-22 mirMAP -0.392645378804653 1.49270892102077e-14 NA NA NA hsa-miR-374a-5p NFAT5 0.543061152108237 2.19403097299769e-14 -0.816417557443788 1.77196856943782e-22 mirMAP;miRNATAP -0.372449132154858 2.03351134775738e-08 NA NA NA hsa-miR-374b-5p NFAT5 0.0804104684417872 0.365593963035077 -0.816417557443788 1.77196856943782e-22 mirMAP;miRNATAP -0.20166729298521 0.0003113618366591 NA NA NA hsa-miR-450b-5p NFAT5 0.404819502355575 0.00357671373841274 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.126955999787477 0.00032238939754855 NA NA NA hsa-miR-452-5p NFAT5 2.05325688842141 2.82238393643084e-40 -0.816417557443788 1.77196856943782e-22 MirTarget -0.202973585000611 7.5541087334292e-14 NA NA NA hsa-miR-497-5p NFAT5 0.227757383708836 0.0600073987853074 -0.816417557443788 1.77196856943782e-22 MirTarget -0.206237759229403 3.12385769411036e-07 NA NA NA hsa-miR-576-5p NFAT5 1.06681109513983 5.69294424466526e-24 -0.816417557443788 1.77196856943782e-22 MirTarget;PITA;mirMAP -0.252927455813257 3.17596100564555e-09 NA NA NA hsa-miR-590-3p NFAT5 1.13702599385212 3.53435739887793e-22 -0.816417557443788 1.77196856943782e-22 MirTarget;miRanda;mirMAP;miRNATAP -0.254564915596959 3.43257778031531e-11 NA NA NA hsa-miR-590-5p NFAT5 0.709763558412506 1.11883921359361e-11 -0.816417557443788 1.77196856943782e-22 PITA;mirMAP;miRNATAP -0.25782820483467 1.07817309318776e-08 NA NA NA hsa-miR-616-5p NFAT5 0.913426384742148 3.78418389333709e-09 -0.816417557443788 1.77196856943782e-22 MirTarget;mirMAP -0.130709708174096 3.15181124028896e-05 NA NA NA hsa-miR-7-1-3p NFAT5 0.544601828025304 5.33830451326047e-07 -0.816417557443788 1.77196856943782e-22 mirMAP -0.168640597733216 0.000160618771418501 NA NA NA hsa-miR-708-3p NFAT5 0.83540388887946 3.55308012540402e-06 -0.816417557443788 1.77196856943782e-22 mirMAP -0.122818293715711 4.32721384567161e-06 NA NA NA hsa-miR-92b-3p NFAT5 0.418630595140165 6.50466149211154e-05 -0.816417557443788 1.77196856943782e-22 miRNATAP -0.155085449452592 0.000914802299673715 NA NA NA hsa-miR-93-5p NFAT5 1.37365940377595 2.37567548683245e-46 -0.816417557443788 1.77196856943782e-22 MirTarget;miRNATAP -0.242199335762023 3.36872210469107e-08 NA NA NA hsa-miR-200b-5p NFATC2 -1.46985752435972 3.43232443788022e-27 0.449362525468644 0.0189141879480816 mirMAP -0.195303131766132 0.00675711085179978 NA NA NA hsa-miR-30b-5p NFATC2 -1.18330589477119 6.8341618466966e-27 0.449362525468644 0.0189141879480816 MirTarget;mirMAP -0.463461325382204 1.11191040571271e-07 NA NA NA hsa-miR-30c-5p NFATC2 -1.08783070774238 2.02505402525786e-24 0.449362525468644 0.0189141879480816 MirTarget;mirMAP -0.271805009769506 0.00325762769077695 NA NA NA hsa-miR-221-3p NFATC3 0.337895669520713 0.0136448974691037 -0.140726285220053 0.0339218322389747 MirTarget;miRNATAP -0.115849278999013 1.12819203212933e-05 NA NA NA hsa-miR-30d-5p NFATC3 -0.202727675788184 0.00659067084745794 -0.140726285220053 0.0339218322389747 MirTarget;miRNATAP -0.140332728977046 0.00452319052730583 NA NA NA hsa-miR-361-5p NFATC3 0.0514169367202078 0.382929376393199 -0.140726285220053 0.0339218322389747 miRanda -0.193117552878382 0.00238037949903394 NA NA NA hsa-miR-29b-3p NFATC4 -0.228125979913806 0.0271621721891603 0.47344681025823 0.000946723727006422 miRNATAP -0.402505484576897 1.23032680444856e-07 NA NA NA hsa-miR-29c-3p NFATC4 -0.238671318446745 0.0141475322347596 0.47344681025823 0.000946723727006422 miRNATAP -0.265114702444064 0.00120757439920213 NA NA NA hsa-miR-3607-3p NFATC4 -0.529788328085356 0.00511771034738625 0.47344681025823 0.000946723727006422 miRNATAP -0.24036070829863 4.41456153455456e-09 NA NA NA hsa-miR-532-5p NFATC4 -1.09700348358668 8.34836230254408e-26 0.47344681025823 0.000946723727006422 mirMAP -0.404648362035331 4.91036144881753e-09 NA NA NA hsa-miR-625-5p NFATC4 0.153090549230629 0.330314026509869 0.47344681025823 0.000946723727006422 mirMAP -0.201502679108411 0.000224845731258786 NA NA NA hsa-miR-629-3p NFATC4 1.09330044556689 2.9533160808356e-14 0.47344681025823 0.000946723727006422 mirMAP -0.150504690909161 0.00533757723845502 NA NA NA hsa-miR-21-5p NKD1 2.51462371613332 3.30620591950316e-66 -3.29439245553428 2.64736766705843e-49 mirMAP -0.711094610300358 3.54235067812357e-21 NA NA NA hsa-miR-330-5p NKD1 1.44960468659754 2.12131210588035e-45 -3.29439245553428 2.64736766705843e-49 miRanda;miRNATAP -0.962768528936515 1.67421097987696e-16 NA NA NA hsa-miR-340-5p NKD1 1.14479851941741 2.91936881701444e-15 -3.29439245553428 2.64736766705843e-49 mirMAP -0.598735379358832 1.00180349311681e-10 NA NA NA hsa-miR-455-5p NKD1 0.773674551205946 2.12957541541474e-09 -3.29439245553428 2.64736766705843e-49 miRanda -0.608124760658548 1.27060058874825e-08 NA NA NA hsa-miR-616-5p NKD1 0.913426384742148 3.78418389333709e-09 -3.29439245553428 2.64736766705843e-49 mirMAP -0.395602516913126 1.52149535557244e-05 NA NA NA hsa-let-7b-5p NLK 0.770868211539597 6.63408323707647e-21 -0.415191050072129 3.56761964031379e-14 miRNATAP -0.213142443996496 1.59741249912824e-09 NA NA NA hsa-let-7i-5p NLK 0.911372377723717 7.11483853341932e-31 -0.415191050072129 3.56761964031379e-14 miRNATAP -0.15295813080395 2.30171838649547e-05 NA NA NA hsa-miR-101-3p NLK 0.683973909682285 2.88573524246948e-15 -0.415191050072129 3.56761964031379e-14 MirTarget;miRNATAP -0.133297067953379 0.000121545107269618 24189458 MiR 101 functions as a tumor suppressor by directly targeting nemo like kinase in liver cancer; Ectopic expression of miRNA mimics suggested that miR-101 could suppress NLK in HCC cells; Notably ectopic miR-101 expression repressed cancer cell growth and proliferation and imitated NLK knockdown effect on HCC cells; In conclusion we suggest that miR-101 functions as a tumor suppressor by regulating abnormal NLK activity in liver liver cancer hsa-miR-140-5p NLK 0.504309496243674 3.09884038729031e-11 -0.415191050072129 3.56761964031379e-14 MirTarget;PITA;miRanda;miRNATAP -0.11126456870982 0.00601003022746845 NA NA NA hsa-miR-181a-5p NLK 1.11111114875339 3.97880443756442e-29 -0.415191050072129 3.56761964031379e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.129246509443587 6.73584541111371e-06 NA NA NA hsa-miR-181b-5p NLK 1.49054296272357 3.69051660739368e-41 -0.415191050072129 3.56761964031379e-14 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.123014704665365 5.43054049724413e-07 NA NA NA hsa-miR-19a-3p NLK 0.722913586880779 2.76301458932381e-10 -0.415191050072129 3.56761964031379e-14 miRNATAP -0.11681032889775 1.00048435447221e-05 NA NA NA hsa-miR-19b-3p NLK 0.195940928879427 0.0300512922542325 -0.415191050072129 3.56761964031379e-14 miRNATAP -0.112498547421501 0.00124622865639122 NA NA NA hsa-miR-23a-3p NLK 0.761438723382355 4.09310879199257e-27 -0.415191050072129 3.56761964031379e-14 miRNAWalker2_validate;MirTarget -0.26618905195001 3.62422734867895e-11 NA NA NA hsa-miR-24-3p NLK 0.173813044685099 0.00565259443420961 -0.415191050072129 3.56761964031379e-14 miRNATAP -0.186569360466789 0.00022297719711918 NA NA NA hsa-miR-25-3p NLK 1.12016166564779 3.79069348635778e-48 -0.415191050072129 3.56761964031379e-14 MirTarget;miRNATAP -0.248032048255658 3.93931440544525e-13 NA NA NA hsa-miR-27a-3p NLK 0.558934437526245 1.44256383086177e-12 -0.415191050072129 3.56761964031379e-14 miRNATAP -0.229917022523536 1.26715697659659e-09 NA NA NA hsa-miR-28-5p NLK 0.461962042257226 3.32424690573327e-11 -0.415191050072129 3.56761964031379e-14 miRanda -0.213854603663167 1.00934235622274e-06 NA NA NA hsa-miR-32-5p NLK 0.407826130035097 7.26884631998646e-06 -0.415191050072129 3.56761964031379e-14 MirTarget;miRNATAP -0.115912233572337 0.000694797834639195 NA NA NA hsa-miR-330-5p NLK 1.44960468659754 2.12131210588035e-45 -0.415191050072129 3.56761964031379e-14 MirTarget;PITA;miRanda;miRNATAP -0.119824580519251 5.32913342569724e-06 NA NA NA hsa-miR-342-3p NLK 1.4124432570595 1.07208971556131e-28 -0.415191050072129 3.56761964031379e-14 miRanda -0.106193658441937 1.96644391627061e-06 NA NA NA hsa-miR-576-5p NLK 1.06681109513983 5.69294424466526e-24 -0.415191050072129 3.56761964031379e-14 MirTarget;PITA -0.145124878973303 9.73821201873753e-08 NA NA NA hsa-miR-590-3p NLK 1.13702599385212 3.53435739887793e-22 -0.415191050072129 3.56761964031379e-14 PITA;miRanda;mirMAP;miRNATAP -0.118746280650687 1.60415916418526e-06 NA NA NA hsa-miR-590-5p NLK 0.709763558412506 1.11883921359361e-11 -0.415191050072129 3.56761964031379e-14 miRanda -0.130841023902023 5.79659168032456e-06 NA NA NA hsa-miR-92a-3p NLK 0.178194888895831 0.0088835082650834 -0.415191050072129 3.56761964031379e-14 MirTarget;miRNATAP -0.137090969174483 0.00328930488596389 NA NA NA hsa-miR-92b-3p NLK 0.418630595140165 6.50466149211154e-05 -0.415191050072129 3.56761964031379e-14 miRNAWalker2_validate;MirTarget;miRNATAP -0.102401695791903 0.00055081635376696 NA NA NA hsa-miR-107 PLCB1 0.140046250553248 0.0943611632552367 -0.172333333596628 0.245615971393608 PITA;miRanda;miRNATAP -0.514480181778509 1.20781731400067e-07 NA NA NA hsa-miR-130b-3p PLCB1 1.12788913578446 2.939369462276e-16 -0.172333333596628 0.245615971393608 miRNATAP -0.16524345131132 0.00353237391861853 NA NA NA hsa-miR-361-5p PLCB1 0.0514169367202078 0.382929376393199 -0.172333333596628 0.245615971393608 PITA;miRanda -0.775470983327896 3.13019837544917e-08 NA NA NA hsa-miR-421 PLCB1 0.313155739887734 0.020433534776003 -0.172333333596628 0.245615971393608 miRanda -0.270498146364636 1.27764950703977e-05 NA NA NA hsa-miR-616-5p PLCB1 0.913426384742148 3.78418389333709e-09 -0.172333333596628 0.245615971393608 mirMAP -0.177585544391015 0.000674624708039865 NA NA NA hsa-miR-125a-3p PLCB2 -0.372794471295036 0.000941729459601642 2.2736914555885 3.23933472762208e-40 miRanda;miRNATAP -0.377837208906368 6.50785354084262e-05 NA NA NA hsa-miR-628-5p PLCB2 -0.293936745442736 0.0769541076905808 2.2736914555885 3.23933472762208e-40 miRNATAP -0.175047556149576 0.00671876244309961 NA NA NA hsa-miR-125a-5p PLCB3 -0.561874059994802 7.3931856356891e-13 0.484592696685468 2.11674096242145e-10 miRanda -0.180898924691292 0.000739415011750321 NA NA NA hsa-let-7a-3p PLCB4 0.0677487960013088 0.460458477653989 0.49302558959204 0.00538602138987861 mirMAP;miRNATAP -0.473701089977617 9.54015083027853e-06 NA NA NA hsa-miR-337-3p PLCB4 -1.30943131486669 8.52435193863553e-12 0.49302558959204 0.00538602138987861 PITA -0.161086412040677 0.00119893285760461 NA NA NA hsa-miR-361-5p PLCB4 0.0514169367202078 0.382929376393199 0.49302558959204 0.00538602138987861 miRanda -0.58805553815865 0.000564853970884571 NA NA NA hsa-miR-374b-5p PLCB4 0.0804104684417872 0.365593963035077 0.49302558959204 0.00538602138987861 mirMAP -0.292372686393723 0.00883033361765267 NA NA NA hsa-miR-455-5p PORCN 0.773674551205946 2.12957541541474e-09 -0.512360043687667 5.0616764376553e-08 miRanda -0.25913020145204 2.66376146194359e-11 NA NA NA hsa-miR-148a-3p PPARD 0.343233211643815 0.00402279073598165 0.681879660272646 2.77407749498053e-14 mirMAP -0.126876229830409 0.0032103400797229 NA NA NA hsa-miR-29a-3p PPARD -0.431613225927952 4.10166815070288e-08 0.681879660272646 2.77407749498053e-14 miRNATAP -0.312896778655332 1.03149806767395e-06 NA NA NA hsa-miR-29b-3p PPARD -0.228125979913806 0.0271621721891603 0.681879660272646 2.77407749498053e-14 miRNATAP -0.201757907777609 4.92113568182467e-05 NA NA NA hsa-miR-30b-3p PPARD -1.64703050862226 1.89878531036464e-31 0.681879660272646 2.77407749498053e-14 mirMAP -0.229055533117391 1.17240423049859e-12 NA NA NA hsa-miR-324-3p PPARD -0.197662887871899 0.0298845059559819 0.681879660272646 2.77407749498053e-14 mirMAP -0.174012954739573 0.00225477141422539 NA NA NA hsa-miR-429 PPARD -2.16569233119434 2.66862243626443e-37 0.681879660272646 2.77407749498053e-14 miRNATAP -0.101368508590864 0.000157516794376642 NA NA NA hsa-miR-17-3p PPP2CA 0.723795600017259 5.90151677164931e-18 -0.0986621185828058 0.0322311495916405 MirTarget -0.115609136292778 5.1945828551556e-05 NA NA NA hsa-miR-590-3p PPP2CB 1.13702599385212 3.53435739887793e-22 -0.487343407097616 6.12363210381507e-16 miRanda -0.148108586350573 5.65176554878302e-08 NA NA NA hsa-miR-146b-5p PPP2R1B 1.40714170253819 2.9559871816487e-12 -0.454734829935764 5.04192101717804e-14 miRanda -0.106167714667314 4.04187575982608e-11 NA NA NA hsa-miR-15a-5p PPP2R1B 1.42663930007845 1.36006952074963e-57 -0.454734829935764 5.04192101717804e-14 MirTarget -0.158870694074697 7.39147854946692e-07 NA NA NA hsa-miR-15b-5p PPP2R1B 0.773001494057531 1.71784656078957e-16 -0.454734829935764 5.04192101717804e-14 MirTarget -0.155184743390608 9.11437716247661e-06 NA NA NA hsa-miR-16-5p PPP2R1B 0.934012514027655 4.85417898318515e-24 -0.454734829935764 5.04192101717804e-14 miRNAWalker2_validate;MirTarget -0.157201852909443 5.57771892550489e-06 NA NA NA hsa-miR-186-5p PPP2R1B 0.507217561043443 9.04455748270995e-10 -0.454734829935764 5.04192101717804e-14 mirMAP -0.144865494129061 0.000395809025710765 NA NA NA hsa-miR-195-5p PPP2R1B 0.346502644882604 0.0092562828415903 -0.454734829935764 5.04192101717804e-14 MirTarget -0.11856735020381 3.74905556486083e-06 NA NA NA hsa-miR-320a PPP2R1B 0.412740558379182 2.02929519701706e-05 -0.454734829935764 5.04192101717804e-14 miRanda -0.150930956528645 1.79572706330847e-05 NA NA NA hsa-miR-330-5p PPP2R1B 1.44960468659754 2.12131210588035e-45 -0.454734829935764 5.04192101717804e-14 miRanda -0.167386992703103 5.71928058591198e-09 NA NA NA hsa-miR-452-5p PPP2R1B 2.05325688842141 2.82238393643084e-40 -0.454734829935764 5.04192101717804e-14 MirTarget -0.116940593190983 1.2480959791507e-09 NA NA NA hsa-miR-497-5p PPP2R1B 0.227757383708836 0.0600073987853074 -0.454734829935764 5.04192101717804e-14 MirTarget -0.132380804791297 2.85132271643844e-06 NA NA NA hsa-miR-576-5p PPP2R1B 1.06681109513983 5.69294424466526e-24 -0.454734829935764 5.04192101717804e-14 mirMAP -0.107694240077987 0.00039255398459087 NA NA NA hsa-miR-590-3p PPP2R1B 1.13702599385212 3.53435739887793e-22 -0.454734829935764 5.04192101717804e-14 MirTarget;miRanda;mirMAP -0.11445817178589 2.96165176993764e-05 NA NA NA hsa-miR-107 PPP2R5A 0.140046250553248 0.0943611632552367 -0.643260112244032 1.19448793398462e-23 miRanda -0.231984993904772 2.77426347732745e-07 NA NA NA hsa-miR-1270 PPP2R5A 1.71697026896618 1.75919401373445e-16 -0.643260112244032 1.19448793398462e-23 PITA -0.108411888808129 1.55082077643523e-10 NA NA NA hsa-miR-197-3p PPP2R5A 0.297760714271229 0.00102679606305048 -0.643260112244032 1.19448793398462e-23 MirTarget -0.228728341471082 2.81026889555884e-08 NA NA NA hsa-miR-338-5p PPP2R5A 0.628429807914222 1.27575140717947e-06 -0.643260112244032 1.19448793398462e-23 MirTarget;PITA;miRNATAP -0.112112043091588 0.000125681253522379 NA NA NA hsa-miR-34a-5p PPP2R5A 1.07544567720768 1.81510842038009e-20 -0.643260112244032 1.19448793398462e-23 MirTarget;miRNATAP -0.195614443431858 7.33832868103353e-11 NA NA NA hsa-miR-455-5p PPP2R5A 0.773674551205946 2.12957541541474e-09 -0.643260112244032 1.19448793398462e-23 miRanda -0.274481257130099 7.27133740241979e-25 NA NA NA hsa-miR-484 PPP2R5A 0.571987778099603 9.67278224458421e-10 -0.643260112244032 1.19448793398462e-23 miRNAWalker2_validate -0.242719264343379 4.20537162281745e-10 NA NA NA hsa-miR-590-3p PPP2R5A 1.13702599385212 3.53435739887793e-22 -0.643260112244032 1.19448793398462e-23 miRNAWalker2_validate -0.198606455287551 1.60759444974742e-11 NA NA NA hsa-miR-15a-5p PPP2R5C 1.42663930007845 1.36006952074963e-57 -0.310564619725865 1.06102495468945e-11 miRNATAP -0.141061635081439 3.02504267033446e-09 NA NA NA hsa-miR-15b-5p PPP2R5C 0.773001494057531 1.71784656078957e-16 -0.310564619725865 1.06102495468945e-11 miRNATAP -0.148937407861973 8.54026373815838e-09 NA NA NA hsa-miR-16-5p PPP2R5C 0.934012514027655 4.85417898318515e-24 -0.310564619725865 1.06102495468945e-11 miRNAWalker2_validate;miRNATAP -0.126911598501026 8.65262570174567e-07 NA NA NA hsa-miR-186-5p PPP2R5C 0.507217561043443 9.04455748270995e-10 -0.310564619725865 1.06102495468945e-11 mirMAP;miRNATAP -0.114342123059645 0.00017947862593708 NA NA NA hsa-miR-193a-3p PPP2R5C 0.849206638484406 3.68101781083335e-14 -0.310564619725865 1.06102495468945e-11 PITA;miRanda;miRNATAP -0.124782283187022 1.02036760294786e-08 NA NA NA hsa-miR-28-3p PPP2R5C 1.01277915413238 1.8655970171461e-43 -0.310564619725865 1.06102495468945e-11 PITA -0.191969270641742 2.36352576421493e-10 NA NA NA hsa-miR-455-5p PPP2R5C 0.773674551205946 2.12957541541474e-09 -0.310564619725865 1.06102495468945e-11 miRanda -0.108446370508491 1.51254254916574e-08 NA NA NA hsa-let-7a-3p PPP2R5E 0.0677487960013088 0.460458477653989 -0.544089570321744 5.01720071232967e-12 mirMAP -0.14378874755493 0.0035624757595797 NA NA NA hsa-miR-130b-3p PPP2R5E 1.12788913578446 2.939369462276e-16 -0.544089570321744 5.01720071232967e-12 mirMAP -0.136050970638676 1.00710403158397e-05 NA NA NA hsa-miR-16-2-3p PPP2R5E 1.3046118743965 4.17207934608428e-19 -0.544089570321744 5.01720071232967e-12 mirMAP -0.110084678266901 0.000137054684628662 NA NA NA hsa-miR-181a-5p PPP2R5E 1.11111114875339 3.97880443756442e-29 -0.544089570321744 5.01720071232967e-12 MirTarget;mirMAP -0.212554818637739 2.0467778649869e-07 NA NA NA hsa-miR-181b-5p PPP2R5E 1.49054296272357 3.69051660739368e-41 -0.544089570321744 5.01720071232967e-12 MirTarget;mirMAP -0.224267051383363 1.06337675354213e-10 NA NA NA hsa-miR-19a-3p PPP2R5E 0.722913586880779 2.76301458932381e-10 -0.544089570321744 5.01720071232967e-12 MirTarget -0.12207156145816 0.00137627997426489 NA NA NA hsa-miR-19b-3p PPP2R5E 0.195940928879427 0.0300512922542325 -0.544089570321744 5.01720071232967e-12 miRTarBase;MirTarget -0.156314478032495 0.00174984372588633 NA NA NA hsa-miR-23a-3p PPP2R5E 0.761438723382355 4.09310879199257e-27 -0.544089570321744 5.01720071232967e-12 MirTarget -0.273723372973 2.97454423201905e-06 24997345 Downregulation of PPP2R5E expression by miR 23a suppresses apoptosis to facilitate the growth of gastric cancer cells; Here we declare that PPP2R5E is downregulated by miR-23a and induces cell growth inhibition and apoptosis in gastric cancer cells; PPP2R5E is identified as a new target of miR-23a; Moreover overexpression of PPP2R5E reversed the negative effects of miR-23a; We highlight the significance of miR-23a and PPP2R5E in the proliferation and apoptosis of gastric cancer cells gastric cancer hsa-miR-330-5p PPP2R5E 1.44960468659754 2.12131210588035e-45 -0.544089570321744 5.01720071232967e-12 miRanda -0.13912757041665 0.000243786785499114 NA NA NA hsa-miR-342-3p PPP2R5E 1.4124432570595 1.07208971556131e-28 -0.544089570321744 5.01720071232967e-12 miRanda -0.116005646717339 0.000317225910037246 NA NA NA hsa-miR-365a-3p PPP2R5E 0.80809616164259 2.36039522526e-12 -0.544089570321744 5.01720071232967e-12 miRNAWalker2_validate -0.216509219959858 4.68542600488872e-09 NA NA NA hsa-miR-374a-3p PPP2R5E 1.13863935833993 2.79089304015401e-44 -0.544089570321744 5.01720071232967e-12 MirTarget -0.237358886571338 6.18027184651909e-07 NA NA NA hsa-miR-455-5p PPP2R5E 0.773674551205946 2.12957541541474e-09 -0.544089570321744 5.01720071232967e-12 miRanda -0.196435386840447 3.41583355965528e-09 NA NA NA hsa-miR-542-3p PPP2R5E 0.431147917094433 0.000254981247606435 -0.544089570321744 5.01720071232967e-12 miRanda -0.109255011480076 0.00390671074201949 NA NA NA hsa-miR-590-3p PPP2R5E 1.13702599385212 3.53435739887793e-22 -0.544089570321744 5.01720071232967e-12 MirTarget;PITA;miRanda;mirMAP -0.146818389290623 3.75489241809668e-05 NA NA NA hsa-miR-590-5p PPP2R5E 0.709763558412506 1.11883921359361e-11 -0.544089570321744 5.01720071232967e-12 miRanda -0.124058531639696 0.00293906504926364 NA NA NA hsa-miR-30a-5p PPP3CA -0.778411951775343 2.73322451127932e-16 0.0721387123808759 0.234245285293813 miRNAWalker2_validate;miRNATAP -0.118629097747329 0.000383615066757291 NA NA NA hsa-miR-107 PPP3CB 0.140046250553248 0.0943611632552367 -0.487246812937051 5.19737132609125e-20 miRanda -0.100574744257312 0.00721500275471322 NA NA NA hsa-miR-15a-5p PPP3CB 1.42663930007845 1.36006952074963e-57 -0.487246812937051 5.19737132609125e-20 miRNATAP -0.192283738442317 1.15661216413766e-11 NA NA NA hsa-miR-15b-5p PPP3CB 0.773001494057531 1.71784656078957e-16 -0.487246812937051 5.19737132609125e-20 miRNATAP -0.136453760306784 1.39939898640127e-05 NA NA NA hsa-miR-16-5p PPP3CB 0.934012514027655 4.85417898318515e-24 -0.487246812937051 5.19737132609125e-20 miRNATAP -0.134414377057782 1.56084628439769e-05 NA NA NA hsa-miR-330-5p PPP3CB 1.44960468659754 2.12131210588035e-45 -0.487246812937051 5.19737132609125e-20 MirTarget;PITA;miRanda -0.152969334053742 2.9174642891742e-09 NA NA NA hsa-miR-452-5p PPP3CB 2.05325688842141 2.82238393643084e-40 -0.487246812937051 5.19737132609125e-20 MirTarget;miRNATAP -0.117886106917456 6.18756426826884e-12 NA NA NA hsa-miR-590-3p PPP3CB 1.13702599385212 3.53435739887793e-22 -0.487246812937051 5.19737132609125e-20 miRanda -0.12233415261172 5.67792394940471e-07 NA NA NA hsa-miR-500a-3p PPP3CC -1.41379327701944 2.73403824528455e-37 0.254109049885576 7.06908011746755e-08 MirTarget;miRNATAP -0.121534092684039 4.7654464774239e-09 NA NA NA hsa-miR-27b-3p PPP3R1 -0.699527231242518 1.07356023759234e-15 0.157646059727901 0.00380302425401831 miRNATAP -0.147266842249843 7.02192582599604e-06 NA NA NA hsa-miR-30a-5p PPP3R1 -0.778411951775343 2.73322451127932e-16 0.157646059727901 0.00380302425401831 miRNAWalker2_validate;MirTarget;miRNATAP -0.144832345464806 1.24508531197761e-06 NA NA NA hsa-miR-30b-5p PPP3R1 -1.18330589477119 6.8341618466966e-27 0.157646059727901 0.00380302425401831 MirTarget -0.144184046476476 4.67346408532333e-09 NA NA NA hsa-miR-30d-5p PPP3R1 -0.202727675788184 0.00659067084745794 0.157646059727901 0.00380302425401831 MirTarget;miRNATAP -0.210347143440493 1.4459363165293e-07 NA NA NA hsa-miR-17-5p PRICKLE1 0.494260110870015 3.8348005261e-09 -1.07454204633698 6.42089526524012e-14 miRNAWalker2_validate -0.392271694214085 4.43001864934492e-05 NA NA NA hsa-miR-215-5p PRICKLE1 1.57223951497888 6.18833867819653e-10 -1.07454204633698 6.42089526524012e-14 miRNAWalker2_validate -0.118373814338915 0.000160217963138795 NA NA NA hsa-miR-361-5p PRICKLE1 0.0514169367202078 0.382929376393199 -1.07454204633698 6.42089526524012e-14 miRanda -0.40500647078664 0.00476151297568231 NA NA NA hsa-miR-542-3p PRICKLE1 0.431147917094433 0.000254981247606435 -1.07454204633698 6.42089526524012e-14 miRanda -0.234535084810544 0.00071257865957913 NA NA NA hsa-miR-132-3p PRICKLE2 0.291409674711894 0.000912684337101876 -0.108048404702991 0.256228080676637 MirTarget;miRNATAP -0.16937271314455 0.00458153120032521 NA NA NA hsa-miR-148a-5p PRICKLE2 0.415500302855613 0.000691460831436767 -0.108048404702991 0.256228080676637 mirMAP -0.121859025863024 0.0042139128069263 NA NA NA hsa-miR-182-5p PRICKLE2 -0.608710746044567 0.0025264935278104 -0.108048404702991 0.256228080676637 MirTarget -0.121387473235444 1.98725592863064e-06 NA NA NA hsa-miR-29a-3p PRICKLE2 -0.431613225927952 4.10166815070288e-08 -0.108048404702991 0.256228080676637 MirTarget;miRNATAP -0.295878656989839 5.93235559428139e-06 NA NA NA hsa-miR-29b-3p PRICKLE2 -0.228125979913806 0.0271621721891603 -0.108048404702991 0.256228080676637 MirTarget;miRNATAP -0.235122404549224 3.03722107928218e-06 NA NA NA hsa-miR-589-5p PRICKLE2 0.696241532021631 5.26958362886071e-16 -0.108048404702991 0.256228080676637 MirTarget;miRNATAP -0.171477521707343 0.0034424782101509 NA NA NA hsa-miR-590-3p PRICKLE2 1.13702599385212 3.53435739887793e-22 -0.108048404702991 0.256228080676637 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.11480716554164 0.00611019600277936 NA NA NA hsa-miR-16-2-3p PRKACB 1.3046118743965 4.17207934608428e-19 -0.68047992720199 6.2289588419962e-18 mirMAP -0.110421791682537 0.000180893091391508 NA NA NA hsa-miR-17-5p PRKACB 0.494260110870015 3.8348005261e-09 -0.68047992720199 6.2289588419962e-18 TargetScan -0.177111212378275 0.000974492661946987 NA NA NA hsa-miR-18a-5p PRKACB 0.936704393213466 1.05064580570579e-10 -0.68047992720199 6.2289588419962e-18 miRNATAP -0.129810473204045 2.02983188773094e-05 NA NA NA hsa-miR-193a-3p PRKACB 0.849206638484406 3.68101781083335e-14 -0.68047992720199 6.2289588419962e-18 miRanda -0.152325629995289 0.000102213273809685 NA NA NA hsa-miR-19a-3p PRKACB 0.722913586880779 2.76301458932381e-10 -0.68047992720199 6.2289588419962e-18 MirTarget;miRNATAP -0.149521467816826 0.000117450056574833 NA NA NA hsa-miR-19b-3p PRKACB 0.195940928879427 0.0300512922542325 -0.68047992720199 6.2289588419962e-18 miRNAWalker2_validate;MirTarget;miRNATAP -0.151382160966433 0.0030186219386488 NA NA NA hsa-miR-34a-5p PRKACB 1.07544567720768 1.81510842038009e-20 -0.68047992720199 6.2289588419962e-18 miRNATAP -0.155553394908043 2.5599855449644e-05 NA NA NA hsa-miR-590-3p PRKACB 1.13702599385212 3.53435739887793e-22 -0.68047992720199 6.2289588419962e-18 MirTarget;PITA;miRanda;miRNATAP -0.170298039845818 2.59547529658115e-06 NA NA NA hsa-miR-590-5p PRKACB 0.709763558412506 1.11883921359361e-11 -0.68047992720199 6.2289588419962e-18 miRanda -0.122511813057726 0.00404292608644287 NA NA NA hsa-miR-93-5p PRKACB 1.37365940377595 2.37567548683245e-46 -0.68047992720199 6.2289588419962e-18 miRNAWalker2_validate -0.230489200796702 1.41605310708363e-08 NA NA NA hsa-miR-142-5p PRKCA 1.88417391525707 1.2096808039882e-27 -1.40949595564765 3.30510040485645e-31 mirMAP -0.203326926537334 1.32429030012509e-07 NA NA NA hsa-miR-146a-5p PRKCA 1.04938133739924 7.51013231709992e-12 -1.40949595564765 3.30510040485645e-31 mirMAP -0.138636449569245 0.00290151925750071 NA NA NA hsa-miR-150-5p PRKCA 1.00371863159681 1.09871676395528e-09 -1.40949595564765 3.30510040485645e-31 mirMAP -0.141463696474327 0.00116284963615584 NA NA NA hsa-miR-17-3p PRKCA 0.723795600017259 5.90151677164931e-18 -1.40949595564765 3.30510040485645e-31 miRNAWalker2_validate -0.55301268177802 1.37146521298911e-11 NA NA NA hsa-miR-181a-5p PRKCA 1.11111114875339 3.97880443756442e-29 -1.40949595564765 3.30510040485645e-31 mirMAP -0.540264161188695 1.18526956498458e-16 NA NA NA hsa-miR-181b-5p PRKCA 1.49054296272357 3.69051660739368e-41 -1.40949595564765 3.30510040485645e-31 mirMAP -0.473733908349652 2.1676855775351e-17 NA NA NA hsa-miR-181c-5p PRKCA 0.762784646696248 4.48373118147729e-10 -1.40949595564765 3.30510040485645e-31 mirMAP -0.256287812602341 1.11910895047438e-05 NA NA NA hsa-miR-186-5p PRKCA 0.507217561043443 9.04455748270995e-10 -1.40949595564765 3.30510040485645e-31 miRNATAP -0.239864584666343 0.00624473839846306 NA NA NA hsa-miR-19b-1-5p PRKCA 0.66692013055553 1.55789130176287e-09 -1.40949595564765 3.30510040485645e-31 mirMAP -0.193605809138291 0.00310670883960429 NA NA NA hsa-miR-224-5p PRKCA 2.84654230414912 3.0480927226395e-47 -1.40949595564765 3.30510040485645e-31 mirMAP -0.224468346181721 5.75169704731423e-13 NA NA NA hsa-miR-2355-3p PRKCA 1.32757890426926 1.88016636795886e-18 -1.40949595564765 3.30510040485645e-31 mirMAP -0.261610517007587 1.83229270594567e-08 NA NA NA hsa-miR-3170 PRKCA 0.664452094631118 2.78926402033808e-05 -1.40949595564765 3.30510040485645e-31 mirMAP -0.143525555001005 0.00205070350789402 NA NA NA hsa-miR-330-3p PRKCA 0.912906550436308 3.35037014057665e-13 -1.40949595564765 3.30510040485645e-31 mirMAP -0.261128612369017 5.50369517469821e-06 NA NA NA hsa-miR-340-5p PRKCA 1.14479851941741 2.91936881701444e-15 -1.40949595564765 3.30510040485645e-31 mirMAP -0.258076358061294 7.18198801898922e-08 NA NA NA hsa-miR-374a-3p PRKCA 1.13863935833993 2.79089304015401e-44 -1.40949595564765 3.30510040485645e-31 mirMAP -0.684628765839887 6.42429291388675e-20 NA NA NA hsa-miR-374a-5p PRKCA 0.543061152108237 2.19403097299769e-14 -1.40949595564765 3.30510040485645e-31 mirMAP -0.522893225273422 1.47637062832505e-07 NA NA NA hsa-miR-452-5p PRKCA 2.05325688842141 2.82238393643084e-40 -1.40949595564765 3.30510040485645e-31 mirMAP -0.33224472833984 1.34300342334138e-16 NA NA NA hsa-miR-590-3p PRKCA 1.13702599385212 3.53435739887793e-22 -1.40949595564765 3.30510040485645e-31 PITA;miRanda;mirMAP;miRNATAP -0.332392461839564 9.25847276505916e-09 NA NA NA hsa-miR-592 PRKCA 2.6404220268798 8.81369998128794e-32 -1.40949595564765 3.30510040485645e-31 miRNATAP -0.172568846986646 3.52884206079864e-09 NA NA NA hsa-miR-200b-3p PRKCB -1.70383252137161 2.38979336321755e-30 0.583904117599654 0.000239395825023428 MirTarget -0.161635318424647 0.00276990701776461 NA NA NA hsa-miR-27b-3p PRKCB -0.699527231242518 1.07356023759234e-15 0.583904117599654 0.000239395825023428 MirTarget;miRNATAP -0.381848642069096 8.29210459175488e-05 NA NA NA hsa-miR-30a-3p PRKCB -0.955360819934585 1.97009535429185e-20 0.583904117599654 0.000239395825023428 mirMAP -0.27445649163855 0.000675651397734009 NA NA NA hsa-miR-30b-5p PRKCB -1.18330589477119 6.8341618466966e-27 0.583904117599654 0.000239395825023428 mirMAP -0.43302228945984 2.35087485736611e-09 NA NA NA hsa-miR-30c-5p PRKCB -1.08783070774238 2.02505402525786e-24 0.583904117599654 0.000239395825023428 mirMAP -0.200266218821399 0.00954411836448046 NA NA NA hsa-miR-30d-3p PRKCB -0.249777194282131 0.00235356711813496 0.583904117599654 0.000239395825023428 mirMAP -0.527711285390385 8.06872957758744e-07 NA NA NA hsa-miR-30d-5p PRKCB -0.202727675788184 0.00659067084745794 0.583904117599654 0.000239395825023428 mirMAP -0.615678537820375 1.81242737170691e-07 NA NA NA hsa-miR-361-5p PRKCB 0.0514169367202078 0.382929376393199 0.583904117599654 0.000239395825023428 MirTarget;miRanda;miRNATAP -0.499291115851109 0.00117224790143438 NA NA NA hsa-miR-429 PRKCB -2.16569233119434 2.66862243626443e-37 0.583904117599654 0.000239395825023428 MirTarget;miRanda;miRNATAP -0.192274100704377 2.89126645159923e-05 NA NA NA hsa-miR-126-5p PRKX 0.785607261431085 5.77058629454465e-13 -0.824466674997549 1.24178637796187e-14 MirTarget;miRNATAP -0.225620112374926 3.14306953584905e-05 NA NA NA hsa-miR-128-3p PRKX 0.475045893035043 2.6255647468e-06 -0.824466674997549 1.24178637796187e-14 MirTarget -0.354668377255749 1.84548885162361e-09 NA NA NA hsa-miR-140-3p PRKX 0.989350547007025 6.14964028267239e-25 -0.824466674997549 1.24178637796187e-14 mirMAP -0.238393239812655 5.88038969986026e-05 NA NA NA hsa-miR-143-5p PRKX 0.297037599500085 0.0442949119420742 -0.824466674997549 1.24178637796187e-14 miRNATAP -0.112746271955476 0.00680173941413137 NA NA NA hsa-miR-144-3p PRKX 1.4617706700291 9.18139413836375e-11 -0.824466674997549 1.24178637796187e-14 MirTarget -0.13272578965549 3.71142728059944e-07 NA NA NA hsa-miR-148a-3p PRKX 0.343233211643815 0.00402279073598165 -0.824466674997549 1.24178637796187e-14 MirTarget -0.26948947078394 1.06219908024953e-07 NA NA NA hsa-miR-148b-3p PRKX 0.346011252093377 4.27203463315056e-06 -0.824466674997549 1.24178637796187e-14 MirTarget -0.318456532820279 8.82988200529867e-05 NA NA NA hsa-miR-148b-5p PRKX 0.269550343699955 0.0383631776794927 -0.824466674997549 1.24178637796187e-14 mirMAP -0.130567047783336 0.0074991694843521 NA NA NA hsa-miR-16-1-3p PRKX 1.51429140700091 3.17219833254498e-37 -0.824466674997549 1.24178637796187e-14 MirTarget -0.360359060096853 1.04124203973636e-15 NA NA NA hsa-miR-16-2-3p PRKX 1.3046118743965 4.17207934608428e-19 -0.824466674997549 1.24178637796187e-14 MirTarget;mirMAP -0.185239493595492 2.50440890419259e-06 NA NA NA hsa-miR-181a-5p PRKX 1.11111114875339 3.97880443756442e-29 -0.824466674997549 1.24178637796187e-14 mirMAP -0.354450125800361 1.7110841075268e-10 NA NA NA hsa-miR-181b-5p PRKX 1.49054296272357 3.69051660739368e-41 -0.824466674997549 1.24178637796187e-14 mirMAP -0.309398411713712 7.9863573419145e-11 NA NA NA hsa-miR-195-3p PRKX 0.808592887366705 6.8151241038711e-09 -0.824466674997549 1.24178637796187e-14 MirTarget;mirMAP -0.150691727177806 0.000502555427500189 NA NA NA hsa-miR-19a-3p PRKX 0.722913586880779 2.76301458932381e-10 -0.824466674997549 1.24178637796187e-14 miRNATAP -0.145006279305195 0.00566274166698371 NA NA NA hsa-miR-218-5p PRKX -0.81077534785501 3.0631582201951e-08 -0.824466674997549 1.24178637796187e-14 miRNATAP -0.123260848996704 0.002728147543298 NA NA NA hsa-miR-224-5p PRKX 2.84654230414912 3.0480927226395e-47 -0.824466674997549 1.24178637796187e-14 mirMAP -0.102297987942287 0.000128251231211549 NA NA NA hsa-miR-23a-3p PRKX 0.761438723382355 4.09310879199257e-27 -0.824466674997549 1.24178637796187e-14 mirMAP -0.324733496416332 5.67635968371776e-05 NA NA NA hsa-miR-27a-3p PRKX 0.558934437526245 1.44256383086177e-12 -0.824466674997549 1.24178637796187e-14 MirTarget;miRNATAP -0.250273883699444 0.000969807865024322 NA NA NA hsa-miR-29c-3p PRKX -0.238671318446745 0.0141475322347596 -0.824466674997549 1.24178637796187e-14 mirMAP -0.174256475739199 0.00607897894760014 NA NA NA hsa-miR-330-3p PRKX 0.912906550436308 3.35037014057665e-13 -0.824466674997549 1.24178637796187e-14 MirTarget -0.212099933368802 9.66208692931154e-06 NA NA NA hsa-miR-374a-3p PRKX 1.13863935833993 2.79089304015401e-44 -0.824466674997549 1.24178637796187e-14 mirMAP -0.39192911160223 1.37147903262365e-09 NA NA NA hsa-miR-421 PRKX 0.313155739887734 0.020433534776003 -0.824466674997549 1.24178637796187e-14 miRanda -0.209773371514651 6.65889163437683e-06 NA NA NA hsa-miR-576-5p PRKX 1.06681109513983 5.69294424466526e-24 -0.824466674997549 1.24178637796187e-14 mirMAP -0.187960886178378 0.000516056334679525 NA NA NA hsa-miR-590-3p PRKX 1.13702599385212 3.53435739887793e-22 -0.824466674997549 1.24178637796187e-14 mirMAP -0.299538297188508 4.45201426482462e-10 NA NA NA hsa-miR-625-3p PRKX 1.09679549288964 4.60800634006165e-20 -0.824466674997549 1.24178637796187e-14 mirMAP -0.135091209992979 0.00538503960183476 NA NA NA hsa-miR-140-5p PSEN1 0.504309496243674 3.09884038729031e-11 -0.381365150522178 9.21164607796299e-14 MirTarget;miRanda -0.155979219768955 3.10610727490787e-05 NA NA NA hsa-miR-17-5p PSEN1 0.494260110870015 3.8348005261e-09 -0.381365150522178 9.21164607796299e-14 TargetScan -0.124895548621956 0.00025338378540957 NA NA NA hsa-miR-186-5p PSEN1 0.507217561043443 9.04455748270995e-10 -0.381365150522178 9.21164607796299e-14 mirMAP -0.153607510572279 7.75300218040988e-06 NA NA NA hsa-miR-27a-3p PSEN1 0.558934437526245 1.44256383086177e-12 -0.381365150522178 9.21164607796299e-14 miRNATAP -0.236258971549425 1.5723020002032e-11 NA NA NA hsa-miR-320a PSEN1 0.412740558379182 2.02929519701706e-05 -0.381365150522178 9.21164607796299e-14 miRanda;mirMAP -0.145760071113934 8.45876503241825e-07 NA NA NA hsa-miR-330-5p PSEN1 1.44960468659754 2.12131210588035e-45 -0.381365150522178 9.21164607796299e-14 miRanda -0.154584366211109 1.54285974528465e-10 NA NA NA hsa-miR-576-5p PSEN1 1.06681109513983 5.69294424466526e-24 -0.381365150522178 9.21164607796299e-14 mirMAP -0.101004348070368 8.00138886854432e-05 NA NA NA hsa-miR-590-3p PSEN1 1.13702599385212 3.53435739887793e-22 -0.381365150522178 9.21164607796299e-14 miRanda;mirMAP -0.119059169378953 2.23143788709271e-07 NA NA NA hsa-miR-342-3p RAC3 1.4124432570595 1.07208971556131e-28 -1.40504132869683 4.24492750834751e-13 miRanda -0.303985376974766 0.000136219209735901 NA NA NA hsa-miR-139-5p RBX1 -0.704802495091118 2.36904108453776e-06 0.297788237367175 1.0599388303487e-05 miRanda -0.155038438111231 1.54107038013013e-10 NA NA NA hsa-miR-142-5p ROCK2 1.88417391525707 1.2096808039882e-27 -0.438241772728277 4.55989418069368e-05 PITA -0.119983248967754 0.000146164845804185 NA NA NA hsa-miR-340-5p ROCK2 1.14479851941741 2.91936881701444e-15 -0.438241772728277 4.55989418069368e-05 mirMAP -0.142692540339737 0.00028753869695702 NA NA NA hsa-miR-590-3p ROCK2 1.13702599385212 3.53435739887793e-22 -0.438241772728277 4.55989418069368e-05 miRanda;mirMAP -0.242292958829534 2.83581289233021e-07 NA NA NA hsa-miR-140-5p RUVBL1 0.504309496243674 3.09884038729031e-11 -0.282754815138064 8.54200967745155e-07 miRanda -0.111090654822316 0.00732782808454243 NA NA NA hsa-miR-106b-5p SENP2 1.07509411417907 2.11739194181878e-36 -0.107513183097876 0.0503350785000859 mirMAP -0.158178619788352 4.38402332108646e-07 NA NA NA hsa-miR-1271-5p SFRP1 0.900599702972936 3.07963385418853e-10 -6.72745240941721 1.9741325361747e-76 mirMAP -0.935571391893478 3.9719556764976e-08 NA NA NA hsa-miR-1301-3p SFRP1 0.393537638993954 0.000390498879474539 -6.72745240941721 1.9741325361747e-76 MirTarget -0.814199430842928 0.000353545491558244 NA NA NA hsa-miR-144-3p SFRP1 1.4617706700291 9.18139413836375e-11 -6.72745240941721 1.9741325361747e-76 MirTarget;miRNATAP -0.547752901720784 4.06383036099132e-07 NA NA NA hsa-miR-146a-5p SFRP1 1.04938133739924 7.51013231709992e-12 -6.72745240941721 1.9741325361747e-76 MirTarget -0.946895365400288 1.77064009262476e-09 NA NA NA hsa-miR-146b-5p SFRP1 1.40714170253819 2.9559871816487e-12 -6.72745240941721 1.9741325361747e-76 MirTarget -0.843390207692544 8.51250295462547e-13 NA NA NA hsa-miR-16-1-3p SFRP1 1.51429140700091 3.17219833254498e-37 -6.72745240941721 1.9741325361747e-76 MirTarget -1.75055415502597 7.31488845345297e-22 NA NA NA hsa-miR-19b-1-5p SFRP1 0.66692013055553 1.55789130176287e-09 -6.72745240941721 1.9741325361747e-76 MirTarget -1.12753811318698 4.3219412563047e-07 NA NA NA hsa-miR-27a-3p SFRP1 0.558934437526245 1.44256383086177e-12 -6.72745240941721 1.9741325361747e-76 MirTarget;miRNATAP -1.88566378766955 8.96268932831741e-10 NA NA NA hsa-miR-484 SFRP1 0.571987778099603 9.67278224458421e-10 -6.72745240941721 1.9741325361747e-76 MirTarget -1.27789179412824 1.28983947669007e-06 NA NA NA hsa-miR-486-5p SFRP1 1.16748143760361 1.68410465883829e-08 -6.72745240941721 1.9741325361747e-76 MirTarget;miRanda -0.572465876933945 1.44794265463149e-06 NA NA NA hsa-miR-576-5p SFRP1 1.06681109513983 5.69294424466526e-24 -6.72745240941721 1.9741325361747e-76 MirTarget;PITA -1.9117524322024 2.63414907936094e-19 NA NA NA hsa-miR-7-1-3p SFRP1 0.544601828025304 5.33830451326047e-07 -6.72745240941721 1.9741325361747e-76 MirTarget;mirMAP -1.10265418660015 1.44645692623341e-06 NA NA NA hsa-miR-455-5p SFRP2 0.773674551205946 2.12957541541474e-09 0.513694134588167 0.217992042829291 miRanda -1.00822111180636 3.27773163185399e-09 NA NA NA hsa-miR-429 SFRP4 -2.16569233119434 2.66862243626443e-37 0.407466742313577 0.0618304568350401 miRanda -0.263094136413292 2.67416497460191e-05 NA NA NA hsa-miR-532-5p SFRP4 -1.09700348358668 8.34836230254408e-26 0.407466742313577 0.0618304568350401 MirTarget -0.388701882820144 0.000263635488674725 NA NA NA hsa-miR-130b-3p SKP1 1.12788913578446 2.939369462276e-16 -0.381098934914684 1.76040032439263e-12 MirTarget -0.152738841764484 9.68738568000021e-14 NA NA NA hsa-miR-106b-5p SMAD2 1.07509411417907 2.11739194181878e-36 -0.323525857741032 2.23720043114496e-11 mirMAP -0.227921158638246 1.08811372967107e-16 NA NA NA hsa-miR-142-5p SMAD2 1.88417391525707 1.2096808039882e-27 -0.323525857741032 2.23720043114496e-11 mirMAP;miRNATAP -0.103618518834479 1.24250681485868e-13 NA NA NA hsa-miR-148b-3p SMAD2 0.346011252093377 4.27203463315056e-06 -0.323525857741032 2.23720043114496e-11 MirTarget;mirMAP -0.159371781791692 9.32204012025227e-06 NA NA NA hsa-miR-181a-5p SMAD2 1.11111114875339 3.97880443756442e-29 -0.323525857741032 2.23720043114496e-11 mirMAP -0.111196305883891 9.05817772311089e-06 24394555 Here we show that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target Smad7 miR-181a and phosphorylated Smad2 are enriched in recurrent compared with matched-primary ovarian tumours and their expression is associated with shorter time to recurrence and poor outcome in patients with EOC recurrence ovarian cancer hsa-miR-181b-5p SMAD2 1.49054296272357 3.69051660739368e-41 -0.323525857741032 2.23720043114496e-11 mirMAP -0.121061562672026 1.31421344246454e-08 NA NA NA hsa-miR-186-5p SMAD2 0.507217561043443 9.04455748270995e-10 -0.323525857741032 2.23720043114496e-11 mirMAP -0.119891748076015 0.000207363898523546 NA NA NA hsa-miR-28-3p SMAD2 1.01277915413238 1.8655970171461e-43 -0.323525857741032 2.23720043114496e-11 mirMAP -0.161662869809801 6.30266644116871e-07 NA NA NA hsa-miR-361-3p SMAD2 1.08992546227594 1.13197240706704e-36 -0.323525857741032 2.23720043114496e-11 miRNATAP -0.164501760249365 3.64651837826174e-09 22675530 Functional analyses showed that Smad2 and TGFß1 are not dysregulated by miR-361-3p and miR-625* in the lung cell line A549 respectively lung cancer hsa-miR-361-5p SMAD2 0.0514169367202078 0.382929376393199 -0.323525857741032 2.23720043114496e-11 MirTarget -0.143014051357446 0.00265133449369938 NA NA NA hsa-miR-3613-5p SMAD2 1.6648190889407 3.78720979041391e-41 -0.323525857741032 2.23720043114496e-11 mirMAP -0.131514745649209 3.84595509882195e-12 NA NA NA hsa-miR-374a-3p SMAD2 1.13863935833993 2.79089304015401e-44 -0.323525857741032 2.23720043114496e-11 mirMAP -0.1697571733512 3.62987531624032e-09 NA NA NA hsa-miR-374a-5p SMAD2 0.543061152108237 2.19403097299769e-14 -0.323525857741032 2.23720043114496e-11 MirTarget -0.153917787865928 3.39287856117158e-05 NA NA NA hsa-miR-455-5p SMAD2 0.773674551205946 2.12957541541474e-09 -0.323525857741032 2.23720043114496e-11 miRanda -0.10107849465895 7.22542945679077e-07 NA NA NA hsa-miR-484 SMAD2 0.571987778099603 9.67278224458421e-10 -0.323525857741032 2.23720043114496e-11 miRNAWalker2_validate -0.114497326283267 5.78354380226944e-05 NA NA NA hsa-miR-590-3p SMAD2 1.13702599385212 3.53435739887793e-22 -0.323525857741032 2.23720043114496e-11 MirTarget;PITA;mirMAP;miRNATAP -0.103830667568495 1.50902215009462e-06 NA NA NA hsa-miR-769-5p SMAD2 0.376837385738096 4.45440414144944e-07 -0.323525857741032 2.23720043114496e-11 MirTarget;PITA;miRNATAP -0.110502416552027 0.0024196210430541 NA NA NA hsa-miR-15a-5p SMAD3 1.42663930007845 1.36006952074963e-57 -0.244139438487666 3.92004830247932e-05 MirTarget -0.146828051928466 1.64894295267973e-06 NA NA NA hsa-miR-185-5p SMAD3 1.05056378692621 1.31174187880682e-22 -0.244139438487666 3.92004830247932e-05 MirTarget -0.120508170275662 2.37794014383956e-05 NA NA NA hsa-miR-186-5p SMAD3 0.507217561043443 9.04455748270995e-10 -0.244139438487666 3.92004830247932e-05 mirMAP -0.123358679164461 0.00159252671121764 NA NA NA hsa-miR-28-5p SMAD3 0.461962042257226 3.32424690573327e-11 -0.244139438487666 3.92004830247932e-05 miRNATAP -0.19375315100781 2.75344519177763e-05 NA NA NA hsa-miR-330-5p SMAD3 1.44960468659754 2.12131210588035e-45 -0.244139438487666 3.92004830247932e-05 miRanda -0.113884725915202 4.1000924834805e-05 NA NA NA hsa-miR-106b-5p SMAD4 1.07509411417907 2.11739194181878e-36 -0.353252154932229 3.49222750370295e-11 mirMAP;miRNATAP -0.263637533078296 2.2876546815193e-18 NA NA NA hsa-miR-130b-3p SMAD4 1.12788913578446 2.939369462276e-16 -0.353252154932229 3.49222750370295e-11 miRNAWalker2_validate;miRNATAP -0.162522896714783 4.30068548257445e-16 NA NA NA hsa-miR-140-5p SMAD4 0.504309496243674 3.09884038729031e-11 -0.353252154932229 3.49222750370295e-11 miRanda -0.107841915991596 0.00567505288961576 NA NA NA hsa-miR-142-5p SMAD4 1.88417391525707 1.2096808039882e-27 -0.353252154932229 3.49222750370295e-11 mirMAP -0.124573552703085 3.87297476256703e-16 NA NA NA hsa-miR-146b-5p SMAD4 1.40714170253819 2.9559871816487e-12 -0.353252154932229 3.49222750370295e-11 PITA;miRanda;miRNATAP -0.111309409867936 7.89967750234915e-16 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-17-5p SMAD4 0.494260110870015 3.8348005261e-09 -0.353252154932229 3.49222750370295e-11 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.10418923812489 0.00325465373100142 NA NA NA hsa-miR-186-5p SMAD4 0.507217561043443 9.04455748270995e-10 -0.353252154932229 3.49222750370295e-11 miRNAWalker2_validate;mirMAP -0.177554906278362 5.12602285863497e-07 NA NA NA hsa-miR-18a-5p SMAD4 0.936704393213466 1.05064580570579e-10 -0.353252154932229 3.49222750370295e-11 miRNAWalker2_validate -0.128383600075071 6.85100350670596e-11 NA NA NA hsa-miR-21-3p SMAD4 1.78837590049697 1.41655409877312e-33 -0.353252154932229 3.49222750370295e-11 mirMAP -0.14165903491177 7.06231943439386e-16 NA NA NA hsa-miR-25-3p SMAD4 1.12016166564779 3.79069348635778e-48 -0.353252154932229 3.49222750370295e-11 mirMAP -0.170081576681957 4.0925836995647e-07 NA NA NA hsa-miR-27a-3p SMAD4 0.558934437526245 1.44256383086177e-12 -0.353252154932229 3.49222750370295e-11 MirTarget -0.184807695672174 5.04606618085533e-07 NA NA NA hsa-miR-28-3p SMAD4 1.01277915413238 1.8655970171461e-43 -0.353252154932229 3.49222750370295e-11 mirMAP -0.207433269425429 5.47829137446523e-09 NA NA NA hsa-miR-28-5p SMAD4 0.461962042257226 3.32424690573327e-11 -0.353252154932229 3.49222750370295e-11 miRanda;miRNATAP -0.21240385695608 4.4009301490775e-07 NA NA NA hsa-miR-34a-5p SMAD4 1.07544567720768 1.81510842038009e-20 -0.353252154932229 3.49222750370295e-11 miRNATAP -0.1492964045371 4.41797602386054e-10 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-374a-5p SMAD4 0.543061152108237 2.19403097299769e-14 -0.353252154932229 3.49222750370295e-11 mirMAP -0.174206701078802 2.102512853859e-05 NA NA NA hsa-miR-454-3p SMAD4 0.68285296887698 1.17407812677787e-08 -0.353252154932229 3.49222750370295e-11 miRNAWalker2_validate;miRNATAP -0.110750938966582 5.950349811848e-06 NA NA NA hsa-miR-550a-3p SMAD4 1.11969632674498 4.64306608686e-12 -0.353252154932229 3.49222750370295e-11 mirMAP -0.106391130547082 3.02572283040143e-08 NA NA NA hsa-miR-576-5p SMAD4 1.06681109513983 5.69294424466526e-24 -0.353252154932229 3.49222750370295e-11 mirMAP -0.136869509225643 1.80782557368588e-07 NA NA NA hsa-miR-589-5p SMAD4 0.696241532021631 5.26958362886071e-16 -0.353252154932229 3.49222750370295e-11 miRNATAP -0.193467970204694 5.08567008607218e-09 NA NA NA hsa-miR-590-3p SMAD4 1.13702599385212 3.53435739887793e-22 -0.353252154932229 3.49222750370295e-11 MirTarget;PITA;miRanda;miRNATAP -0.131595936977223 2.76221280456342e-08 NA NA NA hsa-miR-590-5p SMAD4 0.709763558412506 1.11883921359361e-11 -0.353252154932229 3.49222750370295e-11 miRanda -0.118750766795147 1.98749735856504e-05 NA NA NA hsa-miR-625-5p SMAD4 0.153090549230629 0.330314026509869 -0.353252154932229 3.49222750370295e-11 MirTarget -0.106797654899829 1.9034803009163e-07 NA NA NA hsa-miR-92b-3p SMAD4 0.418630595140165 6.50466149211154e-05 -0.353252154932229 3.49222750370295e-11 mirMAP -0.15850878585623 1.70467008693526e-08 NA NA NA hsa-miR-93-5p SMAD4 1.37365940377595 2.37567548683245e-46 -0.353252154932229 3.49222750370295e-11 miRNAWalker2_validate;mirMAP;miRNATAP -0.149231105698466 2.4808337153461e-08 NA NA NA hsa-miR-106b-5p TBL1X 1.07509411417907 2.11739194181878e-36 -0.257113268504113 0.00136098186026585 mirMAP;miRNATAP -0.281511820455294 7.5254702869318e-10 NA NA NA hsa-miR-142-3p TBL1X 1.88928758773299 2.72985643829893e-22 -0.257113268504113 0.00136098186026585 MirTarget;PITA;miRanda;miRNATAP -0.111649240879242 1.01816853087806e-07 NA NA NA hsa-miR-17-5p TBL1X 0.494260110870015 3.8348005261e-09 -0.257113268504113 0.00136098186026585 TargetScan;mirMAP;miRNATAP -0.179431597308259 0.00056521093302298 NA NA NA hsa-miR-185-5p TBL1X 1.05056378692621 1.31174187880682e-22 -0.257113268504113 0.00136098186026585 MirTarget -0.140459265676435 0.000274650520946112 NA NA NA hsa-miR-19a-3p TBL1X 0.722913586880779 2.76301458932381e-10 -0.257113268504113 0.00136098186026585 mirMAP -0.123134780900933 0.00111410281817812 NA NA NA hsa-miR-19b-3p TBL1X 0.195940928879427 0.0300512922542325 -0.257113268504113 0.00136098186026585 mirMAP -0.144288355310909 0.00356530782724352 NA NA NA hsa-miR-20a-5p TBL1X 0.702602695798242 4.06372887613329e-13 -0.257113268504113 0.00136098186026585 mirMAP;miRNATAP -0.132909452305373 0.00276857974280119 NA NA NA hsa-miR-22-5p TBL1X -0.197038086012602 0.106234828461117 -0.257113268504113 0.00136098186026585 mirMAP -0.200601082972919 2.27445101441342e-08 NA NA NA hsa-miR-25-3p TBL1X 1.12016166564779 3.79069348635778e-48 -0.257113268504113 0.00136098186026585 mirMAP -0.207917658436354 2.97365330556818e-05 NA NA NA hsa-miR-330-3p TBL1X 0.912906550436308 3.35037014057665e-13 -0.257113268504113 0.00136098186026585 PITA;miRNATAP -0.100651435488358 0.00395392902596723 NA NA NA hsa-miR-484 TBL1X 0.571987778099603 9.67278224458421e-10 -0.257113268504113 0.00136098186026585 PITA -0.204486084965467 9.5248018028395e-06 NA NA NA hsa-miR-625-5p TBL1X 0.153090549230629 0.330314026509869 -0.257113268504113 0.00136098186026585 MirTarget -0.107183280174838 0.00045220254891913 NA NA NA hsa-miR-671-5p TBL1X 0.740296481994777 8.07053661008188e-07 -0.257113268504113 0.00136098186026585 MirTarget -0.124755011267325 2.00205228029483e-05 NA NA NA hsa-miR-92b-3p TBL1X 0.418630595140165 6.50466149211154e-05 -0.257113268504113 0.00136098186026585 mirMAP -0.162617925291691 0.000105923830214003 NA NA NA hsa-miR-93-5p TBL1X 1.37365940377595 2.37567548683245e-46 -0.257113268504113 0.00136098186026585 mirMAP;miRNATAP -0.181936080144946 4.71865710176993e-06 NA NA NA hsa-miR-125a-3p TBL1XR1 -0.372794471295036 0.000941729459601642 0.422393719316285 3.84227941954316e-11 miRanda -0.127443232010683 6.52737051161441e-05 NA NA NA hsa-miR-30a-3p TBL1XR1 -0.955360819934585 1.97009535429185e-20 0.422393719316285 3.84227941954316e-11 mirMAP -0.126281742889021 0.000128945334953758 NA NA NA hsa-miR-30d-3p TBL1XR1 -0.249777194282131 0.00235356711813496 0.422393719316285 3.84227941954316e-11 mirMAP -0.156616283125835 0.000394865001027129 NA NA NA hsa-miR-363-3p TBL1XR1 -1.93551166555337 4.45368477487614e-32 0.422393719316285 3.84227941954316e-11 MirTarget -0.123632631677677 2.2403760875648e-10 NA NA NA hsa-miR-500a-5p TBL1XR1 -1.28374735824553 1.95870374809798e-20 0.422393719316285 3.84227941954316e-11 MirTarget -0.109933304710158 6.60046823713902e-06 NA NA NA hsa-miR-502-3p TBL1XR1 -1.10416310320528 1.55354569985732e-22 0.422393719316285 3.84227941954316e-11 PITA -0.19972352023055 6.85193364487391e-12 NA NA NA hsa-miR-140-5p TBL1Y 0.504309496243674 3.09884038729031e-11 -3.50122176447347 1.15662880277213e-27 miRanda -0.789234759948303 0.00156286571540285 NA NA NA hsa-miR-28-5p TBL1Y 0.461962042257226 3.32424690573327e-11 -3.50122176447347 1.15662880277213e-27 miRanda -1.83471359128739 4.4975035871724e-12 NA NA NA hsa-miR-125a-5p TCF7 -0.561874059994802 7.3931856356891e-13 0.800983591334396 2.32781955910614e-08 miRanda -0.351654489054745 0.000453312167919834 NA NA NA hsa-miR-30a-3p TCF7 -0.955360819934585 1.97009535429185e-20 0.800983591334396 2.32781955910614e-08 mirMAP -0.432566886350102 2.38306454151395e-09 NA NA NA hsa-miR-30c-2-3p TCF7 -1.28402709024345 6.77577627955178e-25 0.800983591334396 2.32781955910614e-08 mirMAP -0.470300813821051 3.08381434439972e-16 NA NA NA hsa-miR-106b-5p TCF7L1 1.07509411417907 2.11739194181878e-36 -0.353358651576814 0.000636790820005788 MirTarget -0.201662989374514 0.000826523926568361 NA NA NA hsa-miR-130b-5p TCF7L1 0.92990617673277 3.75880436852717e-12 -0.353358651576814 0.000636790820005788 MirTarget -0.125537019457948 0.00245869850570135 NA NA NA hsa-miR-142-5p TCF7L1 1.88417391525707 1.2096808039882e-27 -0.353358651576814 0.000636790820005788 PITA -0.172408152881014 7.71722229427548e-09 NA NA NA hsa-miR-15b-3p TCF7L1 1.49422666971434 5.44139893275088e-29 -0.353358651576814 0.000636790820005788 miRNATAP -0.137547474080023 0.000450535402488001 NA NA NA hsa-miR-185-3p TCF7L1 0.993379985307475 2.62011454953707e-13 -0.353358651576814 0.000636790820005788 MirTarget -0.172895415794953 2.48596448017815e-05 NA NA NA hsa-miR-330-5p TCF7L1 1.44960468659754 2.12131210588035e-45 -0.353358651576814 0.000636790820005788 miRanda -0.158576321293599 0.00110943545739978 NA NA NA hsa-miR-590-3p TCF7L1 1.13702599385212 3.53435739887793e-22 -0.353358651576814 0.000636790820005788 PITA;miRanda;miRNATAP -0.243023154608187 7.37033348059868e-08 NA NA NA hsa-miR-93-5p TCF7L1 1.37365940377595 2.37567548683245e-46 -0.353358651576814 0.000636790820005788 MirTarget -0.191557132325036 0.000207674858745899 NA NA NA hsa-let-7g-3p TCF7L2 -0.265047454512772 0.0213585204640049 0.132860579589423 0.0157537353263589 MirTarget;miRNATAP -0.122175872375662 2.64125568776328e-06 NA NA NA hsa-miR-148b-3p TCF7L2 0.346011252093377 4.27203463315056e-06 0.132860579589423 0.0157537353263589 miRNAWalker2_validate -0.123053699025516 0.00215054157997715 NA NA NA hsa-miR-186-5p TCF7L2 0.507217561043443 9.04455748270995e-10 0.132860579589423 0.0157537353263589 mirMAP -0.114110140224956 0.00146204723406782 NA NA NA hsa-miR-625-5p TCF7L2 0.153090549230629 0.330314026509869 0.132860579589423 0.0157537353263589 MirTarget -0.122861050480169 1.76214399156583e-09 NA NA NA hsa-miR-664a-3p TCF7L2 -0.019312777079624 0.825861598748857 0.132860579589423 0.0157537353263589 MirTarget -0.120309945868808 0.000529500336490339 NA NA NA hsa-miR-10b-5p TP53 -0.89971464210447 1.18190532299934e-20 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate;miRTarBase -0.178289673371273 1.01311520211069e-07 NA NA NA hsa-miR-125a-5p TP53 -0.561874059994802 7.3931856356891e-13 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate;miRTarBase;miRanda -0.169369198879199 8.24720080675124e-05 26389681;21777146;23079745 Mechanistically inactivation of miR-125a during cervical carcinogenesis was caused by HPV suppression of p53 expression;In addition wild-type p53 mRNA and protein expression was increased by hsa-miR-125a-5p overexpression; Moreover blocking wild-type p53 attenuated the effect of hsa-miR-125a-5p on apoptosis; In loss-of-function experiments wild-type p53 mRNA and protein expression was decreased by blocking hsa-miR-125a-5p; The effect of hsa-miR-125a-5p inhibitor on apoptosis was also weakened by blocking wild-type p53;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity tumorigenesis;; cervical and endocervical cancer;lung cancer;liver cancer hsa-miR-125b-5p TP53 -0.825456421494266 2.13029877878434e-15 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate;miRTarBase -0.164499575889924 1.96885947372224e-07 24846940;26335100;24137477;26686386;24402874;21399871;23585871;24762088;24169356;23079745 The results revealed that hsa-miR-125b may regulate multiple biological processes and signal transduction pathways and drug-resistant occurrence is associated with cell proliferation cell apoptosis cell cycle and signaling pathways including MAPK Wnt and p53;The carboxy terminal domain of connexin 43 CT Cx43 modulates the expression of p53 by altering miR 125b expression in low grade human breast cancers; In addition CT-Cx43 was exogenously expressed in the breast cancer-derived cell line MCF-7 and its effect on the expression of miR-125b and its downstream target p53 were evaluated as well as its effect on cellular proliferation and death using MTT and LDH assays respectively; Interestingly we found that miR-125b a negative regulator of p53 exhibited an inverse expression relationship with CT-Cx43 in the breast cancer samples tested;TP53 and hsa-miR-125b were observed to form a self-adaptation association;In this study we have investigated the delivery and transfection of wild-type wt- p53 and microRNA-125b miR-125b expressing plasmid DNA in SK-LU-1 human lung adenocarcinoma cells as well as in KrasG12D/p53fl/fl KP genetically engineered mouse model of lung cancer;miR-34a is directly regulated by p53 and acts as tumor suppressor while miR-125b plays a significant role in immune response and apoptosis;In vitro assays revealed that overexpression of miR-125b repressed the endogenous level of p53 protein in human colorectal cancer cells;In this study we further extend our studies by showing that miR-125b represses the protein product of the ink4a/ARF locus p14ARF in two prostate cancer cell lines LNCaP wild type-p53 and 22Rv1 both wild type and mutant p53 as well as in the PC-346C prostate cancer xenograft model that lentivirally overexpressed miR-125b;A stable overexpression of miR-125b in human melanoma cell line Mel-Juso resulted in a G0/G1 cell cycle block and emergence of large cells expressing senescence markers: senescence-associated beta-galactosidase p21 p27 and p53;MiR 125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK independent pathways; Further studies reveal that p53 is regulated by miR-125b; However downregulation of the endogenous miR-125b also results in p53-independent apoptotic pathway leading to apoptosis in p53 mutated U251 cells and p53 knockdown U87 cells;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity; To show the clinical significance of these findings mutations in the DNA binding domain of p53 and promoter methylation of miR-125b were investigated; Four out of nine patients with induced SIRT7 carried mutations in the p53 gene and one patient showed hypermethylation of the miR-125b promoter region ;;;;immune resistance;;;;; gastric cancer;breast cancer;pancreatic cancer;lung cancer;cervical and endocervical cancer;colorectal cancer;prostate cancer;melanoma;glioblastoma;liver cancer hsa-miR-30d-5p TP53 -0.202727675788184 0.00659067084745794 0.517978122391951 5.84571553070906e-18 miRNAWalker2_validate -0.234010250909245 4.72794888119438e-07 NA NA NA hsa-miR-22-3p VANGL1 0.198460552200729 0.00761005672059428 -0.0376295574422647 0.598246559348745 mirMAP -0.223754964432761 2.31023477262328e-05 NA NA NA hsa-miR-26a-5p VANGL1 -0.202091714279613 0.00166918288801054 -0.0376295574422647 0.598246559348745 mirMAP -0.175016212408326 0.0046681888522813 NA NA NA hsa-let-7b-5p VANGL2 0.770868211539597 6.63408323707647e-21 -1.46538285715679 3.9312500789151e-13 miRNATAP -0.626300203037027 2.0510962968101e-06 NA NA NA hsa-let-7i-5p VANGL2 0.911372377723717 7.11483853341932e-31 -1.46538285715679 3.9312500789151e-13 miRNATAP -0.583042564344927 1.2354863050472e-05 NA NA NA hsa-miR-106b-5p VANGL2 1.07509411417907 2.11739194181878e-36 -1.46538285715679 3.9312500789151e-13 mirMAP -0.614835093145402 3.13793910135898e-07 NA NA NA hsa-miR-128-3p VANGL2 0.475045893035043 2.6255647468e-06 -1.46538285715679 3.9312500789151e-13 MirTarget -0.411028340971415 0.000274294176218015 NA NA NA hsa-miR-140-3p VANGL2 0.989350547007025 6.14964028267239e-25 -1.46538285715679 3.9312500789151e-13 PITA;miRNATAP -0.385146013489102 0.000584896948786432 NA NA NA hsa-miR-15b-3p VANGL2 1.49422666971434 5.44139893275088e-29 -1.46538285715679 3.9312500789151e-13 mirMAP -0.278995303066903 0.000414989637895867 NA NA NA hsa-miR-185-5p VANGL2 1.05056378692621 1.31174187880682e-22 -1.46538285715679 3.9312500789151e-13 MirTarget -0.460119945497012 4.15388916233039e-06 NA NA NA hsa-miR-196a-5p VANGL2 0.440858887700369 2.0077143292463e-05 -1.46538285715679 3.9312500789151e-13 mirMAP -0.417000731792867 0.000164901109917036 NA NA NA hsa-miR-20a-5p VANGL2 0.702602695798242 4.06372887613329e-13 -1.46538285715679 3.9312500789151e-13 mirMAP -0.398330669053299 0.000558737760157874 NA NA NA hsa-miR-27a-3p VANGL2 0.558934437526245 1.44256383086177e-12 -1.46538285715679 3.9312500789151e-13 miRNATAP -0.526696087594273 0.000217106407085108 NA NA NA hsa-miR-589-5p VANGL2 0.696241532021631 5.26958362886071e-16 -1.46538285715679 3.9312500789151e-13 mirMAP -0.633699536181097 7.36975277872936e-07 NA NA NA hsa-miR-590-3p VANGL2 1.13702599385212 3.53435739887793e-22 -1.46538285715679 3.9312500789151e-13 miRanda -0.438626279225689 1.61651441569599e-06 NA NA NA hsa-miR-19a-3p WNT10A 0.722913586880779 2.76301458932381e-10 -1.83582410360244 5.71954036521957e-15 MirTarget -0.335473652738679 0.00366687468356684 NA NA NA hsa-miR-361-3p WNT10A 1.08992546227594 1.13197240706704e-36 -1.83582410360244 5.71954036521957e-15 MirTarget -0.473128812880961 0.000785717692609658 NA NA NA hsa-miR-378a-3p WNT10A 0.287244802401236 0.0501155019984562 -1.83582410360244 5.71954036521957e-15 MirTarget;miRNATAP -0.370442926187425 5.53465686980862e-05 NA NA NA hsa-miR-378c WNT10A 0.755048315231594 3.56147090439556e-06 -1.83582410360244 5.71954036521957e-15 MirTarget;miRNATAP -0.383544069159523 2.83864417632493e-06 NA NA NA hsa-miR-188-5p WNT10B -1.74586655806628 1.50431624674552e-28 2.11831281650398 3.35530016234749e-17 PITA -0.34990711525005 5.72353747736967e-05 NA NA NA hsa-miR-335-5p WNT10B -2.09515619961552 1.03765771499548e-25 2.11831281650398 3.35530016234749e-17 miRNAWalker2_validate -0.244912142870209 0.000303856113346857 NA NA NA hsa-miR-330-3p WNT11 0.912906550436308 3.35037014057665e-13 -2.12120372736476 9.81409313994183e-17 miRNATAP -0.469777058916167 4.94223139272272e-05 NA NA NA hsa-miR-590-3p WNT11 1.13702599385212 3.53435739887793e-22 -2.12120372736476 9.81409313994183e-17 miRanda -0.578179908588024 7.69555081701839e-07 NA NA NA hsa-miR-181a-5p WNT2 1.11111114875339 3.97880443756442e-29 -2.96293208145639 2.47869288523431e-21 miRNAWalker2_validate -1.28470937584115 4.07007441763254e-15 NA NA NA hsa-miR-361-3p WNT2 1.08992546227594 1.13197240706704e-36 -2.96293208145639 2.47869288523431e-21 MirTarget -1.05495281656866 2.17235731910829e-08 NA NA NA hsa-miR-590-3p WNT2 1.13702599385212 3.53435739887793e-22 -2.96293208145639 2.47869288523431e-21 miRanda;mirMAP -0.686723311303017 2.40384279467165e-06 NA NA NA hsa-miR-107 WNT4 0.140046250553248 0.0943611632552367 -2.55367361567085 1.52308888223493e-23 PITA;miRNATAP -0.56828330648821 0.00187197661596264 NA NA NA hsa-miR-126-5p WNT5A 0.785607261431085 5.77058629454465e-13 -1.25649996580397 2.97982315334721e-13 mirMAP -0.497609550494676 7.01940069035601e-09 NA NA NA hsa-miR-140-3p WNT5A 0.989350547007025 6.14964028267239e-25 -1.25649996580397 2.97982315334721e-13 MirTarget;miRNATAP -0.410982799593669 1.53927981205954e-05 NA NA NA hsa-miR-144-5p WNT5A 1.47329317992706 4.31620137156824e-12 -1.25649996580397 2.97982315334721e-13 mirMAP -0.181231886000792 4.64255738631183e-05 NA NA NA hsa-miR-155-5p WNT5A 3.26274490570809 5.06841441826518e-51 -1.25649996580397 2.97982315334721e-13 miRNAWalker2_validate;mirMAP -0.111728607814617 0.00384447853284572 NA NA NA hsa-miR-16-5p WNT5A 0.934012514027655 4.85417898318515e-24 -1.25649996580397 2.97982315334721e-13 miRNAWalker2_validate -0.292442381918752 0.00341475986146058 NA NA NA hsa-miR-195-3p WNT5A 0.808592887366705 6.8151241038711e-09 -1.25649996580397 2.97982315334721e-13 MirTarget;mirMAP;miRNATAP -0.237857210411741 0.000625989364005096 NA NA NA hsa-miR-374b-5p WNT5A 0.0804104684417872 0.365593963035077 -1.25649996580397 2.97982315334721e-13 MirTarget;miRNATAP -0.306774236271591 0.00629832209619688 NA NA NA hsa-miR-455-5p WNT5A 0.773674551205946 2.12957541541474e-09 -1.25649996580397 2.97982315334721e-13 miRanda -0.326532956746668 1.02604153763706e-05 NA NA NA hsa-miR-590-3p WNT5A 1.13702599385212 3.53435739887793e-22 -1.25649996580397 2.97982315334721e-13 miRanda;mirMAP;miRNATAP -0.245049075980974 0.00188051767367072 NA NA NA hsa-miR-9-5p WNT6 -2.23538606210968 1.28143998950751e-12 0.573762768732148 0.00965335988594974 miRNAWalker2_validate -0.110784388738162 0.00310707690872659 NA NA NA hsa-miR-103a-3p WNT7A 0.779373475434461 7.37867196796994e-20 -4.41166816287719 1.36878717328109e-55 MirTarget -1.19405957803875 2.93529853002323e-09 NA NA NA hsa-miR-107 WNT7A 0.140046250553248 0.0943611632552367 -4.41166816287719 1.36878717328109e-55 MirTarget;miRanda -0.635774495658721 0.00436175077900126 NA NA NA hsa-miR-15a-5p WNT7A 1.42663930007845 1.36006952074963e-57 -4.41166816287719 1.36878717328109e-55 MirTarget -1.82815418801503 8.42016646493443e-31 NA NA NA hsa-miR-15b-5p WNT7A 0.773001494057531 1.71784656078957e-16 -4.41166816287719 1.36878717328109e-55 MirTarget -0.95225124568654 3.17065762018165e-07 27195958 WNT7A Regulation by miR 15b in Ovarian Cancer; In the present study we report that WNT7A is a direct target of miR-15b in ovarian cancer; We showed that a luciferase reporter containing the putative binding site of miR-15b in the WNT7A 3'-UTR was significantly repressed by miR-15b; Mutation of the putative binding site of miR-15b in the WNT7A 3'-UTR restored luciferase activity; Furthermore miR-15b was able to repress increased levels of TOPFLASH activity by WNT7A but not those induced by S33Y; Additionally miR-15b dose-dependently decreased WNT7A expression; When we evaluated the prognostic impact of WNT7A and miR-15b expression using TCGA datasets a significant inverse correlation in which high-expression of WNT7A and low-expression of miR-15b was associated with reduced survival rates of ovarian cancer patients; These results suggest that WNT7A is post-transcriptionally regulated by miR-15b which could be down-regulated by promoter hypermethylation potentially via DNMT1 in ovarian cancer poor survival ovarian cancer hsa-miR-16-5p WNT7A 0.934012514027655 4.85417898318515e-24 -4.41166816287719 1.36878717328109e-55 MirTarget -1.37552144473489 2.14582516810069e-14 NA NA NA hsa-miR-224-5p WNT7A 2.84654230414912 3.0480927226395e-47 -4.41166816287719 1.36878717328109e-55 mirMAP -0.756552608402768 8.37037832335284e-24 NA NA NA hsa-miR-374a-3p WNT7A 1.13863935833993 2.79089304015401e-44 -4.41166816287719 1.36878717328109e-55 MirTarget -1.54923790932129 3.58606117705574e-16 NA NA NA hsa-miR-590-3p WNT7A 1.13702599385212 3.53435739887793e-22 -4.41166816287719 1.36878717328109e-55 miRanda -0.92795717032378 1.16187249549145e-10 NA NA NA hsa-miR-592 WNT7A 2.6404220268798 8.81369998128794e-32 -4.41166816287719 1.36878717328109e-55 mirMAP -0.609812603211465 9.69360466921476e-18 NA NA NA hsa-miR-106b-5p WNT7B 1.07509411417907 2.11739194181878e-36 -4.8472421200918 2.43699458537499e-37 mirMAP -1.70326069550996 1.42656486953374e-12 NA NA NA hsa-miR-185-3p WNT7B 0.993379985307475 2.62011454953707e-13 -4.8472421200918 2.43699458537499e-37 mirMAP -0.602968297688633 0.000363506579853172 NA NA NA hsa-miR-330-5p WNT7B 1.44960468659754 2.12131210588035e-45 -4.8472421200918 2.43699458537499e-37 MirTarget;miRanda -1.53270396237407 1.36587050977043e-15 NA NA NA hsa-miR-34a-5p WNT7B 1.07544567720768 1.81510842038009e-20 -4.8472421200918 2.43699458537499e-37 mirMAP -0.658371786662558 0.000569093576396457 NA NA NA hsa-miR-542-3p WNT7B 0.431147917094433 0.000254981247606435 -4.8472421200918 2.43699458537499e-37 mirMAP -0.72576979545906 0.000250997120479415 NA NA NA hsa-miR-320a WNT8B 0.412740558379182 2.02929519701706e-05 -3.82146976752756 1.32105284501703e-51 miRanda -0.71729018598612 1.8385618600578e-05 NA NA NA hsa-miR-17-5p WNT9B 0.494260110870015 3.8348005261e-09 -4.46182424765011 9.94801880083936e-57 TargetScan -1.27999508650342 2.01305065024565e-09 NA NA NA hsa-miR-340-5p WNT9B 1.14479851941741 2.91936881701444e-15 -4.46182424765011 9.94801880083936e-57 mirMAP -0.834276192054844 2.05689589410603e-12 NA NA NA hsa-miR-590-3p WNT9B 1.13702599385212 3.53435739887793e-22 -4.46182424765011 9.94801880083936e-57 miRanda -1.4425596042741 8.97725605112781e-26 NA NA NA hsa-miR-590-5p WNT9B 0.709763558412506 1.11883921359361e-11 -4.46182424765011 9.94801880083936e-57 miRanda -1.21816926991661 2.83884427316911e-13 NA NA NA hsa-miR-942-5p WNT9B 0.978672610596303 3.12802933163696e-12 -4.46182424765011 9.94801880083936e-57 MirTarget -0.798629955626619 1.62476231126677e-10 NA NA NA