miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-125a-5p ABHD2 -0.306104092733909 0.370798466662369 0.627603259477995 0.157155744775769 miRanda;mirMAP -0.268811706663762 0.00545806921823608 NA NA NA hsa-miR-125a-5p ABHD3 -0.306104092733909 0.370798466662369 0.209261862486748 0.584670565904591 PITA;miRanda -0.183547830271204 0.0280263314640752 NA NA NA hsa-miR-141-3p ABL1 1.13131842772144 0.0966666388085424 -0.277344961292003 0.253565306912228 MirTarget -0.116952600700957 4.26330191852953e-06 NA NA NA hsa-miR-19a-3p ABL1 -1.39804789764109 0.00390589133951138 -0.277344961292003 0.253565306912228 mirMAP -0.108708693383143 0.0027239654948134 NA NA NA hsa-miR-29a-3p ABL1 -0.387866348913471 0.226645201041662 -0.277344961292003 0.253565306912228 miRNAWalker2_validate;miRNATAP -0.208043058208282 0.000187770563344968 NA NA NA hsa-miR-29a-5p ABL1 -0.598913843551928 0.0664324113687381 -0.277344961292003 0.253565306912228 MirTarget -0.124927949009151 0.0237173042627714 NA NA NA hsa-miR-29b-3p ABL1 -0.392267406583841 0.343581862655996 -0.277344961292003 0.253565306912228 miRNATAP -0.186467245403971 1.10956263019236e-05 NA NA NA hsa-miR-29c-3p ABL1 -0.133603914094895 0.743610228811317 -0.277344961292003 0.253565306912228 miRNATAP -0.153939878141008 0.000400429203798993 NA NA NA hsa-miR-30b-5p ABL1 -0.68249444596921 0.0731627218334145 -0.277344961292003 0.253565306912228 MirTarget;miRNATAP -0.172888951716207 0.000198339221514664 NA NA NA hsa-miR-30d-5p ABL1 -0.00941045381462047 0.974732483265334 -0.277344961292003 0.253565306912228 MirTarget;miRNATAP -0.148111983184001 0.0155224437031022 NA NA NA hsa-miR-423-5p ABL1 -0.672785038184251 0.0555585596550693 -0.277344961292003 0.253565306912228 MirTarget -0.121848254946346 0.0169993346488141 NA NA NA hsa-miR-125a-5p ACPP -0.306104092733909 0.370798466662369 0.83770812644732 0.230082290435254 MirTarget;miRanda -0.60582082810316 5.74377684538061e-05 NA NA NA hsa-miR-125a-5p ACTBL2 -0.306104092733909 0.370798466662369 1.45099762912125 0.143654192676307 miRanda -0.652474794036633 0.00257888389831885 NA NA NA hsa-miR-125a-5p ACTG2 -0.306104092733909 0.370798466662369 0.66678912489183 0.552810588129136 miRanda -0.657200548404094 0.0073479011907107 NA NA NA hsa-miR-125a-5p ACTL6A -0.306104092733909 0.370798466662369 0.265964217617122 0.192045154108295 miRanda -0.183001422792122 2.45932249819469e-05 NA NA NA hsa-miR-125a-5p ACTN4 -0.306104092733909 0.370798466662369 0.206392163679121 0.522198932614061 mirMAP -0.216842283114292 0.00189733770756202 NA NA NA hsa-miR-125a-5p ADAM9 -0.306104092733909 0.370798466662369 0.413281922506381 0.386741901257229 PITA;miRanda -0.250008990824946 0.0164938908382955 NA NA NA hsa-miR-125a-5p ADAMTS14 -0.306104092733909 0.370798466662369 -0.0773163156869274 0.917579256765439 miRanda;mirMAP -0.681158006702445 2.19377340511767e-05 NA NA NA hsa-miR-125a-5p ADAMTS9 -0.306104092733909 0.370798466662369 -0.595800256011192 0.258544837757477 miRanda -0.259584432473097 0.0244768791160719 NA NA NA hsa-miR-125a-5p ADAP1 -0.306104092733909 0.370798466662369 1.45556498050181 0.0331945335910452 mirMAP -0.781975257971189 7.74579050490913e-08 NA NA NA hsa-miR-125a-5p ADH5 -0.306104092733909 0.370798466662369 0.0521228672541874 0.766191441680446 miRanda -0.106181134518056 0.00467505128578152 NA NA NA hsa-miR-125a-5p ADM2 -0.306104092733909 0.370798466662369 0.376338698663143 0.580671823160546 mirMAP -0.819696343123285 1.11767607123396e-08 NA NA NA hsa-miR-125a-5p AEN -0.306104092733909 0.370798466662369 0.279528949378005 0.326523654648486 miRanda -0.181654465095029 0.00324645437826781 NA NA NA hsa-miR-125a-5p AGTRAP -0.306104092733909 0.370798466662369 -0.0867151211682842 0.793353756034805 miRNAWalker2_validate;miRanda -0.202949865224584 0.00471045394178608 NA NA NA hsa-miR-125a-5p AIFM1 -0.306104092733909 0.370798466662369 0.0805957455079636 0.684922297405041 miRanda -0.114699318132068 0.00731017492153802 NA NA NA hsa-miR-125a-5p AKAP13 -0.306104092733909 0.370798466662369 -0.435130569131752 0.16463354080257 miRanda -0.225973893315294 0.000854680869752468 NA NA NA hsa-miR-125a-5p ALDH1A3 -0.306104092733909 0.370798466662369 0.2606454874807 0.727864412252795 miRanda -0.379639088462607 0.020419374649138 NA NA NA hsa-miR-125a-5p ALPK1 -0.306104092733909 0.370798466662369 -0.366683402996707 0.36057375614464 miRanda -0.524508759324437 3.521659122256e-10 NA NA NA hsa-miR-26b-5p ANAPC1 -1.21629873619115 0.000852008439136243 0.138969248244679 0.578010506705711 miRNAWalker2_validate -0.163734061225962 0.00096240715361076 NA NA NA hsa-miR-100-5p ANAPC11 1.02538658088665 0.0304417081584391 0.331685764516863 0.279288946346465 miRNAWalker2_validate -0.292624929854011 9.14952014385177e-11 NA NA NA hsa-miR-766-3p ANAPC11 -1.20898066261032 0.00153210669165871 0.331685764516863 0.279288946346465 MirTarget -0.221938661746137 0.000133821169934284 NA NA NA hsa-miR-542-3p ANAPC2 -0.893492256632955 0.0206445931147785 -0.199395073941072 0.386560461840493 miRanda -0.136121095883446 0.00173909687294276 NA NA NA hsa-miR-30a-5p ANAPC5 -0.588553206289925 0.175311638663077 -0.117283719069367 0.492143650861076 miRNAWalker2_validate -0.111060601088902 8.26499569704486e-05 NA NA NA hsa-miR-30c-2-3p ANAPC7 -0.620501370724241 0.130134235770203 -0.0190958405318256 0.915670602511165 MirTarget -0.123004083301266 0.000102043734787354 NA NA NA hsa-miR-125a-5p ANKS6 -0.306104092733909 0.370798466662369 0.387925116547766 0.204557543484585 MirTarget -0.17153795388265 0.0099377044260541 NA NA NA hsa-miR-125a-5p ANO6 -0.306104092733909 0.370798466662369 0.0457778880544497 0.902552643620804 miRanda -0.397157527795521 5.52493314516094e-07 NA NA NA hsa-miR-125a-5p ANPEP -0.306104092733909 0.370798466662369 -0.432198454904655 0.665376899316541 PITA;miRanda;miRNATAP -0.587689599613708 0.00701776545609608 NA NA NA hsa-miR-125a-5p ANTXR2 -0.306104092733909 0.370798466662369 0.451963138434534 0.353439903266801 PITA -0.514976643202653 6.78038514237287e-07 NA NA NA hsa-miR-125a-5p ANXA11 -0.306104092733909 0.370798466662369 0.211303837932491 0.525839562935306 mirMAP -0.384049888702351 4.41326096066795e-08 NA NA NA hsa-miR-125a-5p APOD -0.306104092733909 0.370798466662369 0.707455482811429 0.376000095740904 miRanda -0.443350047272135 0.0111125836561257 NA NA NA hsa-miR-125a-5p ARHGAP11B -0.306104092733909 0.370798466662369 0.432095201020402 0.475902569826932 miRanda -0.302798140131091 0.0223206790005327 NA NA NA hsa-miR-125a-5p ARHGAP27 -0.306104092733909 0.370798466662369 0.334876231766494 0.478335779222312 miRanda -0.396220310225555 9.90329381736714e-05 NA NA NA hsa-miR-125a-5p ARHGEF2 -0.306104092733909 0.370798466662369 0.00761210511716648 0.981212621860086 miRanda -0.294902743284152 1.9889521137203e-05 NA NA NA hsa-miR-125a-5p ARMC7 -0.306104092733909 0.370798466662369 0.136105509020704 0.580605546675596 MirTarget;miRanda -0.139957852841458 0.00867357734236756 NA NA NA hsa-miR-125a-5p ARPC5 -0.306104092733909 0.370798466662369 -0.125379251571719 0.532993515701792 miRNAWalker2_validate -0.108571329497656 0.0123167063303558 NA NA NA hsa-miR-125a-5p ARSD -0.306104092733909 0.370798466662369 0.537034104655813 0.122496400095368 miRanda -0.204130162820589 0.00707187527827773 NA NA NA hsa-miR-125a-5p ARSI -0.306104092733909 0.370798466662369 -0.0450738626788971 0.953426603443085 MirTarget;miRanda -0.581720700770596 0.000500201197426859 NA NA NA hsa-miR-125a-5p ASPH -0.306104092733909 0.370798466662369 0.984445818071175 0.0320075928687826 miRanda -0.368846579298021 0.000214990449444702 NA NA NA hsa-miR-125a-5p ATL2 -0.306104092733909 0.370798466662369 -0.000540417613432709 0.998197586095927 miRNAWalker2_validate;miRanda -0.108809677079587 0.0360787488051376 NA NA NA hsa-miR-18a-5p ATM -1.17872230313757 0.0043629711019433 -0.782008167965449 0.0427504884792423 miRNAWalker2_validate;miRTarBase;MirTarget -0.148749521553414 0.0307588662112835 23437304;25963391;23857602;23229340 MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases ;;;progression colorectal cancer;cervical and endocervical cancer;breast cancer;colon cancer hsa-miR-455-5p ATM -0.230512086486246 0.540435117714922 -0.782008167965449 0.0427504884792423 miRanda -0.299882670669308 7.14173705155653e-05 NA NA NA hsa-miR-301a-3p ATR -0.756666069407079 0.0961303802724355 -0.0446831815375814 0.821528099880044 mirMAP -0.101534169491835 0.00132372343168871 NA NA NA hsa-miR-125a-5p B2M -0.306104092733909 0.370798466662369 -0.36412058391975 0.223417038353684 miRanda -0.196763256091804 0.00240260710883481 NA NA NA hsa-miR-125a-5p B3GALNT2 -0.306104092733909 0.370798466662369 0.277770778509271 0.247691958184667 MirTarget;miRanda;miRNATAP -0.130760871365154 0.0120917172327027 NA NA NA hsa-miR-125a-5p B3GNT3 -0.306104092733909 0.370798466662369 4.44305530865778 5.8724817725689e-08 MirTarget -0.806381785483449 1.02955217082951e-05 NA NA NA hsa-miR-125a-5p B3GNT7 -0.306104092733909 0.370798466662369 0.912698089093048 0.224305912919614 mirMAP -0.726449743278279 6.55690965198664e-06 NA NA NA hsa-miR-125a-5p B4GALT1 -0.306104092733909 0.370798466662369 -0.197591833076062 0.596934182488288 miRanda -0.467899357500614 2.13972869168753e-09 NA NA NA hsa-miR-125a-5p BAK1 -0.306104092733909 0.370798466662369 0.346428332101713 0.268217788848193 miRNAWalker2_validate;PITA;miRanda;miRNATAP -0.391831400701216 2.10657636707413e-09 NA NA NA hsa-miR-125a-5p BATF2 -0.306104092733909 0.370798466662369 0.0034527050067763 0.994245984865809 miRanda -0.211767702829196 0.0430709609930872 NA NA NA hsa-miR-125a-5p BAZ1A -0.306104092733909 0.370798466662369 -0.219686309505991 0.531605671541821 miRanda -0.330574133732697 1.06765638142136e-05 NA NA NA hsa-miR-125a-5p BCAT1 -0.306104092733909 0.370798466662369 -0.371107597563237 0.611910693132146 MirTarget -0.429813984308987 0.0070451404264537 NA NA NA hsa-miR-125a-5p BCKDK -0.306104092733909 0.370798466662369 -0.0135823486785229 0.946648308532988 miRanda -0.149684141141706 0.000567990614473742 NA NA NA hsa-miR-125a-5p BCL2L12 -0.306104092733909 0.370798466662369 -0.0723977468889734 0.872678989393096 miRanda;miRNATAP -0.512046253553396 8.19208438416645e-08 NA NA NA hsa-miR-125a-5p BCL2L14 -0.306104092733909 0.370798466662369 1.5534712351921 0.107705245012052 MirTarget;PITA;miRanda -1.31262536931997 7.3445726895282e-11 NA NA NA hsa-miR-125a-5p BIK -0.306104092733909 0.370798466662369 0.911108049656829 0.172020128604099 miRanda -0.4770295540362 0.00100663550387728 NA NA NA hsa-miR-125a-5p BLZF1 -0.306104092733909 0.370798466662369 0.696433536424799 0.0102390765095168 miRanda -0.146115466850346 0.0138787440467044 NA NA NA hsa-miR-125a-5p BMP1 -0.306104092733909 0.370798466662369 -0.0123633333384792 0.976102592600539 mirMAP -0.18672317738003 0.0383158198814711 NA NA NA hsa-miR-125a-5p BMPR1B -0.306104092733909 0.370798466662369 0.223084333524211 0.768002317410373 MirTarget;miRNATAP -0.916168491960519 8.63801425736953e-09 NA NA NA hsa-miR-125a-5p BRCC3 -0.306104092733909 0.370798466662369 0.276755773244619 0.185695060941624 miRanda -0.101034908372577 0.0257877745764145 NA NA NA hsa-miR-125a-5p BTN2A2 -0.306104092733909 0.370798466662369 -1.12494760780357 0.00206897325132807 miRanda -0.251205630075004 0.00171856151986732 NA NA NA hsa-miR-139-5p BUB1 -1.63574949154462 0.00653778531863944 0.746607730546359 0.231704573780695 miRanda -0.349865318838847 2.3630412604799e-06 NA NA NA hsa-miR-324-5p BUB1 -0.993343053719004 0.00956564321262937 0.746607730546359 0.231704573780695 MirTarget -0.265793176153521 0.0273381632775812 NA NA NA hsa-miR-495-3p BUB1 -0.819711095165138 0.0930619218141869 0.746607730546359 0.231704573780695 MirTarget -0.387519839275301 3.01198758000133e-05 NA NA NA hsa-miR-543 BUB1 -1.03495265003894 0.0713462149984802 0.746607730546359 0.231704573780695 miRanda -0.312280091061285 8.70933113360926e-05 NA NA NA hsa-miR-543 BUB1B -1.03495265003894 0.0713462149984802 0.73267644228305 0.184043904562621 miRanda -0.205719639132134 0.00375941775325514 NA NA NA hsa-miR-125a-5p C1RL -0.306104092733909 0.370798466662369 -0.346716813992272 0.314754660138283 miRanda -0.336933827944905 4.73713577997727e-06 NA NA NA hsa-miR-125a-5p C2 -0.306104092733909 0.370798466662369 -0.779736234694472 0.184489786059155 miRanda -0.605354270513556 1.42296761510042e-06 NA NA NA hsa-miR-125a-5p CANT1 -0.306104092733909 0.370798466662369 0.640323188450977 0.0478952947014425 mirMAP -0.359571628378915 1.68224285080716e-07 NA NA NA hsa-miR-125a-5p CASP10 -0.306104092733909 0.370798466662369 -0.175856264888536 0.628889502187424 mirMAP -0.329992689493064 2.30408320420021e-05 NA NA NA hsa-miR-125a-5p CASP6 -0.306104092733909 0.370798466662369 0.221403790485738 0.455313127542931 miRanda -0.342740648633633 3.92727994851623e-08 NA NA NA hsa-miR-125a-5p CBLB -0.306104092733909 0.370798466662369 -0.326437577569361 0.191693350276012 miRanda -0.18725311235401 0.000507215118412094 NA NA NA hsa-let-7b-5p CCNA1 0.133031570393829 0.651804468011451 -0.491135331675528 0.550464478785651 miRNAWalker2_validate -0.802276962186904 0.000113044690335399 NA NA NA hsa-miR-30a-5p CCNA1 -0.588553206289925 0.175311638663077 -0.491135331675528 0.550464478785651 MirTarget -0.310949766744558 0.0267668701785926 NA NA NA hsa-miR-129-5p CCNA2 1.01348286569596 0.367116067584743 0.670715272727192 0.165445785055429 miRanda -0.179429459279749 3.28220157324033e-09 NA NA NA hsa-miR-132-3p CCNA2 -0.188684269862105 0.638562246194811 0.670715272727192 0.165445785055429 miRNAWalker2_validate -0.357703596268813 5.07824600506046e-05 NA NA NA hsa-miR-212-3p CCNA2 -0.367966702435511 0.450158366088537 0.670715272727192 0.165445785055429 miRNAWalker2_validate -0.210637247386878 0.0039969548685289 NA NA NA hsa-miR-218-5p CCNA2 -0.689900257277015 0.125310499823975 0.670715272727192 0.165445785055429 MirTarget -0.263518684280436 0.000834030130010126 NA NA NA hsa-miR-29c-3p CCNA2 -0.133603914094895 0.743610228811317 0.670715272727192 0.165445785055429 MirTarget -0.275195508149886 0.00167308027730917 NA NA NA hsa-miR-301a-3p CCNA2 -0.756666069407079 0.0961303802724355 0.670715272727192 0.165445785055429 miRNATAP -0.202788350972719 0.00997323530853325 NA NA NA hsa-miR-374a-5p CCNA2 -0.773847948304864 0.0214475199454759 0.670715272727192 0.165445785055429 mirMAP -0.213407211245775 0.0464936042608248 NA NA NA hsa-miR-98-5p CCNA2 -0.2176359368719 0.422768546610498 0.670715272727192 0.165445785055429 miRNAWalker2_validate -0.318737686174536 0.0183206687420653 NA NA NA hsa-miR-132-3p CCNB1 -0.188684269862105 0.638562246194811 1.04717990755406 0.0185662604473819 miRNAWalker2_validate -0.261128892463788 0.0015065657085565 NA NA NA hsa-miR-139-5p CCNB1 -1.63574949154462 0.00653778531863944 1.04717990755406 0.0185662604473819 miRanda -0.24490629590422 4.02480997385742e-06 NA NA NA hsa-miR-212-3p CCNB1 -0.367966702435511 0.450158366088537 1.04717990755406 0.0185662604473819 miRNAWalker2_validate -0.183856951717513 0.00661734268711552 NA NA NA hsa-miR-496 CCNB1 -0.263423110562247 0.668883492994483 1.04717990755406 0.0185662604473819 miRanda -0.130873475281268 0.0143952048849332 NA NA NA hsa-miR-543 CCNB1 -1.03495265003894 0.0713462149984802 1.04717990755406 0.0185662604473819 miRanda -0.144631138977061 0.0121416310197496 NA NA NA hsa-miR-23b-3p CCNB2 0.00716511065069625 0.975265102572651 0.796795413482254 0.251805879758028 miRNAWalker2_validate -0.65313630857355 0.00469361368899646 NA NA NA hsa-miR-135a-5p CCND1 -0.197337318548759 0.83089129366921 1.03729468254983 0.017085644156936 mirMAP -0.104192576994355 0.00282015322383284 NA NA NA hsa-miR-142-3p CCND1 -2.40415971573611 4.06932390671969e-05 1.03729468254983 0.017085644156936 miRanda -0.109530749481646 0.0422392283168332 23619912 Transfection of miR-142-3p mimics in colon cancer cells downregulated cyclin D1 expression induced G1 phase cell cycle arrest and elevated the sensitivity of the cells to 5-fluorouracil colon cancer hsa-miR-150-5p CCND1 -1.91230438070411 0.0203531106331021 1.03729468254983 0.017085644156936 mirMAP -0.100407715850891 0.00936854010185589 NA NA NA hsa-miR-15a-5p CCND1 -0.736232967654847 0.0107385113851643 1.03729468254983 0.017085644156936 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.36383682603274 0.00124017794119654 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR sarcoma hsa-miR-16-5p CCND1 -1.02296420363147 0.000327333184982762 1.03729468254983 0.017085644156936 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.349165751459941 0.00207625289308073 23991964;22922827;18483394 At the molecular level our results further revealed that cyclin D1 expression was negatively regulated by miR-16;CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR;Truncation in CCND1 mRNA alters miR 16 1 regulation in mantle cell lymphoma; Furthermore we demonstrated that this truncation alters miR-16-1 binding sites and through the use of reporter constructs we were able to show that miR-16-1 regulates CCND1 mRNA expression; This study introduces the role of miR-16-1 in the regulation of CCND1 in MCL ;; bladder cancer;sarcoma;lymphoma hsa-miR-186-5p CCND1 -0.76553299921128 0.00203425234898652 1.03729468254983 0.017085644156936 mirMAP -0.504869162126262 0.000118338808125741 NA NA NA hsa-miR-195-5p CCND1 -0.685650705852783 0.0717481985943939 1.03729468254983 0.017085644156936 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.23056073080546 0.00668084680431853 21350001;26631043;25823925 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma ;;metastasis;poor survival breast cancer;cervical and endocervical cancer;sarcoma hsa-miR-20b-5p CCND1 -1.44759358558804 0.00948352591621513 1.03729468254983 0.017085644156936 MirTarget;miRNATAP -0.152822612792174 0.00754713069003739 NA NA NA hsa-miR-296-5p CCND1 -1.02399617377153 0.0302986605365734 1.03729468254983 0.017085644156936 miRNAWalker2_validate -0.185277922633319 0.00650958625266218 20485139 Downregulation of miR-296 might inhibit growth of esophageal cancer cells in vitro and in vivo through regulation of cyclin D1 and p27 esophageal cancer hsa-miR-29c-3p CCND1 -0.133603914094895 0.743610228811317 1.03729468254983 0.017085644156936 mirMAP -0.240814641443049 0.00235834444788709 NA NA NA hsa-miR-330-3p CCND1 0.226896608253308 0.63792060187889 1.03729468254983 0.017085644156936 mirMAP -0.219603186259309 0.000983209499128449 NA NA NA hsa-miR-338-3p CCND1 0.514743230435341 0.344476371008619 1.03729468254983 0.017085644156936 miRNAWalker2_validate;miRTarBase;miRanda -0.134092462331291 0.0236977249778284 NA NA NA hsa-miR-33a-3p CCND1 -1.71203223338714 0.000344436075634206 1.03729468254983 0.017085644156936 MirTarget -0.141146301255371 0.0388742923733416 NA NA NA hsa-miR-340-5p CCND1 -0.873554108779771 0.0362049958643107 1.03729468254983 0.017085644156936 mirMAP -0.262203099682235 0.000640184609292728 NA NA NA hsa-miR-374a-5p CCND1 -0.773847948304864 0.0214475199454759 1.03729468254983 0.017085644156936 MirTarget -0.355090335106915 0.000202438154438026 27191497 microRNA 374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway; Furthermore luciferase reporter assays confirmed that miR-374a could directly reduce CCND1; We examined miR-374a levels by in situ hybridization and its correlation with CCND1 expression in CRC tumor tissues; High miR-374a expression with low level of CCND1 was protective factor in CRC; Together these findings indicate that miR-374a inactivates the PI3K/AKT axis by inhibiting CCND1 suppressing of colon cancer progression progression colon cancer hsa-miR-374b-5p CCND1 -0.936361879691007 0.00140373477346958 1.03729468254983 0.017085644156936 miRNAWalker2_validate;MirTarget -0.346630832098542 0.00167412591386981 NA NA NA hsa-miR-495-3p CCND1 -0.819711095165138 0.0930619218141869 1.03729468254983 0.017085644156936 MirTarget -0.223758270379039 0.000635706678876267 NA NA NA hsa-miR-497-5p CCND1 -0.807147224800789 0.0207081588787015 1.03729468254983 0.017085644156936 MirTarget;miRNATAP -0.182926415543884 0.049814031691574 21350001 Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer breast cancer hsa-miR-590-3p CCND1 -0.921957466414335 0.0345620969748757 1.03729468254983 0.017085644156936 mirMAP -0.229595829769722 0.00178952364671911 NA NA NA hsa-miR-7-1-3p CCND1 -0.729687864305395 0.0834004484481893 1.03729468254983 0.017085644156936 mirMAP -0.337063793149052 7.49067704487725e-06 NA NA NA hsa-miR-769-3p CCND1 -0.420704558460553 0.403816672559648 1.03729468254983 0.017085644156936 mirMAP -0.202040784538287 0.00189753227218845 NA NA NA hsa-miR-9-5p CCND1 -0.044480289687975 0.946485755343338 1.03729468254983 0.017085644156936 miRNAWalker2_validate -0.156154351379648 0.00121745096947532 NA NA NA hsa-let-7b-3p CCND2 -0.410613874222772 0.167771473653139 -0.319655648794725 0.535436364862821 mirMAP -0.391325550181008 0.00251741313089439 NA NA NA hsa-miR-10a-3p CCND2 -0.279844305202879 0.538406840309486 -0.319655648794725 0.535436364862821 mirMAP -0.296128544190529 0.000381604997319281 NA NA NA hsa-miR-16-2-3p CCND2 -1.02821208937232 0.00734958396812714 -0.319655648794725 0.535436364862821 mirMAP -0.214414472201153 0.0306947641930395 NA NA NA hsa-miR-17-5p CCND2 -0.667512721923102 0.0423050196597589 -0.319655648794725 0.535436364862821 miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP -0.372764641007049 0.00132445060962467 NA NA NA hsa-miR-181a-2-3p CCND2 -0.830499848042463 0.0433790852903154 -0.319655648794725 0.535436364862821 mirMAP -0.451254864375215 5.67484544384414e-07 NA NA NA hsa-miR-196a-5p CCND2 2.83694083563432 0.0140638339462114 -0.319655648794725 0.535436364862821 miRNAWalker2_validate -0.137632592615852 1.76635325562181e-05 NA NA NA hsa-miR-20a-5p CCND2 -0.39483820331792 0.269587643143535 -0.319655648794725 0.535436364862821 miRNAWalker2_validate;miRTarBase;miRNATAP -0.329385731299914 0.00205645784236131 NA NA NA hsa-miR-21-3p CCND2 -0.439466085308428 0.449347936730943 -0.319655648794725 0.535436364862821 mirMAP -0.257822369281371 6.33893355965719e-05 NA NA NA hsa-miR-224-3p CCND2 -0.911915347414965 0.109316868416341 -0.319655648794725 0.535436364862821 mirMAP -0.254067084408526 0.000114931583258473 NA NA NA hsa-miR-2355-3p CCND2 -0.908712318058918 0.0288015911522534 -0.319655648794725 0.535436364862821 miRNATAP -0.357720991001134 7.38337025567051e-05 NA NA NA hsa-miR-28-5p CCND2 -0.527293772469832 0.0304183293001878 -0.319655648794725 0.535436364862821 miRanda -0.486940304086872 0.0023379654537188 NA NA NA hsa-miR-29a-3p CCND2 -0.387866348913471 0.226645201041662 -0.319655648794725 0.535436364862821 MirTarget;miRNATAP -0.240625983987291 0.0460445955261966 22330340;24130168 In addition to CCND2 miR-29 also targets E2F7 another cell cycle regulator;We further demonstrated that miR-29 family acted as tumor suppressors through targeting CCND2 and matrix metalloproteinase-2 genes in GC ; sarcoma;gastric cancer hsa-miR-30a-3p CCND2 -0.697362237901636 0.139506490831453 -0.319655648794725 0.535436364862821 mirMAP -0.225534137322713 0.0050110146480072 NA NA NA hsa-miR-708-3p CCND2 -0.293049688292744 0.54382185969223 -0.319655648794725 0.535436364862821 mirMAP -0.165026507714334 0.036968796535781 NA NA NA hsa-miR-93-5p CCND2 -0.468459476414832 0.131463449813313 -0.319655648794725 0.535436364862821 miRNATAP -0.345291660181028 0.00536350808599274 NA NA NA hsa-let-7b-5p CCND3 0.133031570393829 0.651804468011451 0.0850238068659932 0.759894684746216 miRNAWalker2_validate -0.247998942553214 0.000399440942434316 NA NA NA hsa-miR-26a-5p CCNE1 -0.595418372285298 0.0245871761064168 0.832315028930682 0.0808669250851865 miRNAWalker2_validate;miRTarBase;miRNATAP -0.383964896294344 0.00465069009471307 22094936 Cell cycle regulation and CCNE1 and CDC2 were the only significant overlapping pathway and genes differentially expressed between tumors with high and low levels of miR-26a and EZH2 respectively; Low mRNA levels of EZH2 CCNE1 and CDC2 and high levels of miR-26a are associated with favorable outcome on tamoxifen breast cancer hsa-miR-874-3p CCNE1 -0.134091707830919 0.772470526227307 0.832315028930682 0.0808669250851865 MirTarget -0.163938459839456 0.0319939931250738 NA NA NA hsa-miR-30b-5p CCNE2 -0.68249444596921 0.0731627218334145 0.429637414357132 0.301543212768301 miRNAWalker2_validate;miRTarBase -0.159731566379461 0.0488904836695894 22384020 A luciferase-based reporter assay demonstrated that miR-30b post-transcriptionally reduced 27% p = 0.005 of the gene expression by interacting with two binding sites in the 3'-UTR of CCNE2; The upregulation of miR-30b by trastuzumab may play a biological role in trastuzumab-induced cell growth inhibition by targeting CCNE2 breast cancer hsa-miR-369-3p CCNE2 -0.832959746953411 0.173640923390195 0.429637414357132 0.301543212768301 PITA -0.143424325509294 0.0039061609415396 NA NA NA hsa-miR-23a-3p CCNH -0.220761521850687 0.399427702087843 -0.00775983264587943 0.967308645051251 MirTarget -0.141872965248136 0.00862594203468861 NA NA NA hsa-miR-23b-3p CCNH 0.00716511065069625 0.975265102572651 -0.00775983264587943 0.967308645051251 MirTarget -0.122055600358862 0.0499733900462591 NA NA NA hsa-miR-125a-5p CCT2 -0.306104092733909 0.370798466662369 0.178312847071519 0.433301239981746 miRanda -0.121486273330977 0.0136535967184258 NA NA NA hsa-miR-125a-5p CD248 -0.306104092733909 0.370798466662369 0.0607750869669026 0.914154628293928 PITA;miRanda;miRNATAP -0.298858034723237 0.0151441133320879 NA NA NA hsa-miR-125a-5p CD276 -0.306104092733909 0.370798466662369 -0.032848964825539 0.921009714496703 miRanda -0.27264339758114 0.000128589935921492 NA NA NA hsa-miR-125a-5p CD300LF -0.306104092733909 0.370798466662369 -1.89036167121189 0.00607890090046458 miRNATAP -0.300358674376301 0.0488011084215999 NA NA NA hsa-miR-125a-5p CDA -0.306104092733909 0.370798466662369 1.33672731799146 0.112156420978955 miRanda -0.535598394512301 0.00356684551412341 NA NA NA hsa-let-7a-3p CDC14A -0.95056529442537 0.00672174661147133 -0.802816304940368 0.0564636634047321 mirMAP -0.241317828580789 0.00658064515552161 NA NA NA hsa-miR-141-3p CDC14A 1.13131842772144 0.0966666388085424 -0.802816304940368 0.0564636634047321 TargetScan;miRNATAP -0.233315431315389 1.19581884412341e-07 NA NA NA hsa-miR-192-5p CDC14A 2.0972919255143 0.00232678828970491 -0.802816304940368 0.0564636634047321 miRNAWalker2_validate -0.145576730005126 0.000991343459584677 NA NA NA hsa-miR-194-5p CDC14A 2.55204029849142 0.000242127029936543 -0.802816304940368 0.0564636634047321 miRNATAP -0.136634538732981 0.00172677606160377 NA NA NA hsa-miR-200a-3p CDC14A 1.68929243108599 0.00872253595562164 -0.802816304940368 0.0564636634047321 miRNATAP -0.193950666315481 3.77624848809416e-05 NA NA NA hsa-miR-429 CDC14A 1.86385884044684 0.00726080911989418 -0.802816304940368 0.0564636634047321 miRanda -0.215189615181871 6.10913081306349e-07 NA NA NA hsa-miR-126-5p CDC14B -1.40161784967373 0.000199780495822923 0.39553133558177 0.146966054508618 MirTarget -0.179360133394125 0.000601457377946851 NA NA NA hsa-miR-140-5p CDC14B -1.19629127894344 4.39286577178892e-05 0.39553133558177 0.146966054508618 miRanda -0.135400600624445 0.0482309926996935 NA NA NA hsa-miR-15a-5p CDC14B -0.736232967654847 0.0107385113851643 0.39553133558177 0.146966054508618 miRNAWalker2_validate;MirTarget -0.214605963221261 0.00219805334548829 NA NA NA hsa-miR-16-5p CDC14B -1.02296420363147 0.000327333184982762 0.39553133558177 0.146966054508618 miRNAWalker2_validate;MirTarget -0.205906171739976 0.0035090794667961 NA NA NA hsa-miR-185-5p CDC14B -0.658536588751586 0.0290776377452413 0.39553133558177 0.146966054508618 MirTarget -0.163390279681903 0.0152499940508956 NA NA NA hsa-miR-450b-5p CDC14B -0.947307681071554 0.0182365957775615 0.39553133558177 0.146966054508618 MirTarget;miRNATAP -0.12221711903579 0.0144127667732184 NA NA NA hsa-miR-501-3p CDC14B -1.02561651155797 0.004055228716503 0.39553133558177 0.146966054508618 PITA -0.127394673776603 0.0235399333171577 NA NA NA hsa-miR-576-5p CDC14B -0.665693542446498 0.0578544351439958 0.39553133558177 0.146966054508618 mirMAP -0.141464422707062 0.0139603602405734 NA NA NA hsa-miR-590-3p CDC14B -0.921957466414335 0.0345620969748757 0.39553133558177 0.146966054508618 miRanda;mirMAP -0.135865905812694 0.00296458616267289 NA NA NA hsa-miR-590-5p CDC14B -0.984421368732497 0.00533663360221062 0.39553133558177 0.146966054508618 miRanda -0.121191191005666 0.0332651153263493 NA NA NA hsa-miR-628-5p CDC14B -0.849175867924745 0.0241095998555431 0.39553133558177 0.146966054508618 miRNATAP -0.144688846294787 0.00661879579525921 NA NA NA hsa-miR-23b-3p CDC20 0.00716511065069625 0.975265102572651 1.02648767956027 0.126503194231066 miRNAWalker2_validate -0.65858574443521 0.00318012613594947 NA NA NA hsa-miR-34a-5p CDC23 -0.243748387753732 0.416958179815378 0.0561915870044851 0.741630029721863 miRNAWalker2_validate -0.122334729425389 0.00341518051762067 NA NA NA hsa-let-7c-5p CDC25A 0.680694390736354 0.127960416639528 0.835831334189099 0.0746354397759946 MirTarget -0.351151518458597 3.87264441634386e-06 25909324 MicroRNA let 7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma; The aim of the present study was to determine whether the cell cycle regulator CDC25A is involved in the antitumor effect of let-7c in HCC; The luciferase reporter assay showed that CDC25A was a direct target of let-7c and that let-7c inhibited the expression of CDC25A protein by directly targeting its 3' UTR; In conclusion this study indicates that let-7c suppresses HCC progression possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules progression liver cancer hsa-miR-195-5p CDC25A -0.685650705852783 0.0717481985943939 0.835831334189099 0.0746354397759946 MirTarget;miRNATAP -0.31421629589279 0.000537094821974639 NA NA NA hsa-miR-337-3p CDC25A -0.591376314419224 0.126490728559043 0.835831334189099 0.0746354397759946 mirMAP -0.232926489065113 0.00967061424318175 NA NA NA hsa-miR-34c-5p CDC25A -0.0182044536033139 0.971130549817106 0.835831334189099 0.0746354397759946 miRNATAP -0.269168530341037 8.23577522136978e-05 21321636 Ectopic expression of miR-449b and miR-34c resulted in lowered adhesion activities by 28%-34% and in cell cycle arrests with increased cell number of 15.62% and 15.71% in G1 and with decreased cell number of 15.96% and 16.56% in S Cell cycle related proteins CDK6 and CDC25A were down-regulated; The decreases of CDK6 and CDC25A by miR-449b were 39% and 22% respecyively; 49% and 32% by miR-34c respectively ovarian cancer hsa-miR-497-5p CDC25A -0.807147224800789 0.0207081588787015 0.835831334189099 0.0746354397759946 MirTarget;miRNATAP -0.236235994159614 0.0181360242589527 NA NA NA hsa-miR-186-5p CDC27 -0.76553299921128 0.00203425234898652 0.00559649513720561 0.973736094554263 mirMAP;miRNATAP -0.122677437200598 0.0154589433686356 NA NA NA hsa-miR-32-5p CDC27 -1.1697502932723 0.00457026320106483 0.00559649513720561 0.973736094554263 miRNAWalker2_validate -0.121284799255236 3.41656604481765e-05 NA NA NA hsa-miR-362-5p CDC27 -0.73199764539445 0.112060703377193 0.00559649513720561 0.973736094554263 miRNATAP -0.107158329216907 4.77495110479968e-05 NA NA NA hsa-miR-137 CDC6 -0.0787835496950151 0.930521869365511 1.4684936716568 0.00558074570056685 miRanda -0.120404253397337 0.00824960829695722 NA NA NA hsa-miR-26a-5p CDC6 -0.595418372285298 0.0245871761064168 1.4684936716568 0.00558074570056685 miRNAWalker2_validate -0.42754734695056 0.0048573302507725 25100863;27158389 Here it is demonstrated that miR26a and miR26b inhibit replication licensing and the proliferation migration and invasion of lung cancer cells by targeting CDC6; The current study suggests that miR26a miR26b and CDC6 and factors regulating their expression represent potential cancer diagnostic and prognostic markers as well as anticancer targets;miR 26a inhibits the proliferation of ovarian cancer cells via regulating CDC6 expression; Bioinformatics analysis revealed Cdc6 was a target gene of miR-26a; dual-luciferase assay and validation assay showed miR-26a could act on the 3'UTR of Cdc6 to regulate Cdc6 expression; These findings suggest that miR-26a may act on the 3'UTR of Cdc6 to regulate Cdc6 expression which then inhibit the proliferation of ovarian cancer cells and induce their apoptosis ; lung cancer;ovarian cancer hsa-miR-342-3p CDC6 -1.50859606438677 0.000361128404069141 1.4684936716568 0.00558074570056685 miRanda -0.220170496278033 0.0170098013195599 NA NA NA hsa-miR-335-5p CDC7 -0.913728460165869 0.0568330413961764 -0.246954854127582 0.484088785567249 MirTarget -0.112182009497135 0.0381747162257525 NA NA NA hsa-miR-429 CDC7 1.86385884044684 0.00726080911989418 -0.246954854127582 0.484088785567249 miRanda -0.115327386209096 0.00168438467002459 NA NA NA hsa-miR-103a-3p CDK2 -0.416159351923632 0.128714644320717 0.0402319994772737 0.888428512347499 miRNAWalker2_validate -0.19997113308614 0.0108767567334897 NA NA NA hsa-miR-23b-3p CDK2 0.00716511065069625 0.975265102572651 0.0402319994772737 0.888428512347499 miRNAWalker2_validate -0.278776429765319 0.00317663621909671 NA NA NA hsa-miR-3065-5p CDK2 0.744542127327022 0.29683696958743 0.0402319994772737 0.888428512347499 mirMAP -0.103107437811073 0.000388837401747241 NA NA NA hsa-miR-361-5p CDK2 -0.298789197467371 0.188640742693303 0.0402319994772737 0.888428512347499 miRNAWalker2_validate -0.477106822981207 3.6274627927372e-07 NA NA NA hsa-miR-375 CDK2 2.45956739868952 0.0171124871214617 0.0402319994772737 0.888428512347499 miRanda -0.121314262705599 2.69609729977976e-10 NA NA NA hsa-miR-376a-3p CDK2 -0.604231855167556 0.342794419886032 0.0402319994772737 0.888428512347499 miRNAWalker2_validate;miRTarBase -0.145656624171804 8.19606200205272e-06 NA NA NA hsa-miR-495-3p CDK2 -0.819711095165138 0.0930619218141869 0.0402319994772737 0.888428512347499 mirMAP -0.152701081168292 0.000340509454438674 NA NA NA hsa-miR-7-1-3p CDK2 -0.729687864305395 0.0834004484481893 0.0402319994772737 0.888428512347499 mirMAP -0.235498206842649 1.41785074784541e-06 NA NA NA hsa-miR-103a-3p CDK6 -0.416159351923632 0.128714644320717 0.111940010637567 0.769764850996177 miRNAWalker2_validate;miRNATAP -0.310890986942033 0.00298500495864706 NA NA NA hsa-miR-1224-5p CDK6 1.83900215224088 0.106580080531242 0.111940010637567 0.769764850996177 miRNATAP -0.101084685754797 4.28775841636865e-05 NA NA NA hsa-miR-136-5p CDK6 -0.939601389376455 0.0581127038651615 0.111940010637567 0.769764850996177 mirMAP -0.148096266826712 0.00877024270031926 NA NA NA hsa-miR-137 CDK6 -0.0787835496950151 0.930521869365511 0.111940010637567 0.769764850996177 miRNAWalker2_validate;miRTarBase;PITA;miRNATAP -0.112239803945812 0.000505586077166081 25342326;18577219;23178712;21051724 Bioinformatics prediction and luciferase reporter assay revealed CDK6 as a target gene through which miR-137 exerted an inhibitory function;Transfection of microRNA-124 or microRNA-137 also induced G1 cell cycle arrest in U251 and SF6969 glioblastoma multiforme cells which was associated with decreased expression of cyclin-dependent kinase 6 and phosphorylated retinoblastoma pSer 807/811 proteins;miR 137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6; Ectopic expression of miR-137 in lung cancer cells significantly downregulated Cdc42 Cdk6 and induced G1 cell cycle arrest leading to a significant decrease in cell growth in vivo and in vitro; Further both Cdc42 and Cdk6 were confirmed as targets of miR-137;The results showed that miR-137 can act as a tumor suppressor in uveal melanoma cell proliferation through downregulation of the targets MITF and CDK6 miR-137 may be epigenetically silenced during uveal melanoma tumorigenesis ;;;tumorigenesis gastric cancer;glioblastoma;lung cancer;melanoma hsa-miR-140-3p CDK6 -0.399322174916632 0.209443645694375 0.111940010637567 0.769764850996177 miRNATAP -0.199649627173581 0.0263607177538049 NA NA NA hsa-miR-148b-3p CDK6 -0.0990745204340264 0.77230139028333 0.111940010637567 0.769764850996177 mirMAP -0.369638396243822 5.9914373158283e-06 NA NA NA hsa-miR-148b-5p CDK6 -0.00680803632441723 0.990051364022285 0.111940010637567 0.769764850996177 mirMAP -0.172797917751687 0.000730918032410873 NA NA NA hsa-miR-15a-5p CDK6 -0.736232967654847 0.0107385113851643 0.111940010637567 0.769764850996177 miRNATAP -0.397529140231463 4.4682256895432e-05 NA NA NA hsa-miR-16-5p CDK6 -1.02296420363147 0.000327333184982762 0.111940010637567 0.769764850996177 miRNAWalker2_validate;miRTarBase -0.230875850543354 0.0202263777236729 NA NA NA hsa-miR-185-5p CDK6 -0.658536588751586 0.0290776377452413 0.111940010637567 0.769764850996177 miRNAWalker2_validate -0.32236806179567 0.000584240380515713 19688090 Using miRNA-target prediction analyses and the array data we listed up a set of likely targets of miR-107 and miR-185 for G1 cell cycle arrest and validate a subset of them using real-time RT-PCR and immunoblotting for CDK6 lung squamous cell cancer hsa-miR-191-5p CDK6 -1.30473175986237 1.60358780788735e-05 0.111940010637567 0.769764850996177 miRNAWalker2_validate;miRTarBase -0.254414405860701 0.00581288278347653 NA NA NA hsa-miR-26a-5p CDK6 -0.595418372285298 0.0245871761064168 0.111940010637567 0.769764850996177 miRNAWalker2_validate;miRTarBase;miRNATAP -0.266389827812684 0.0141123490716902 26314438 Maxvision immunohistochemistry technique was used to detect the expression level of CDK6 and miR-26a in tissue of 20 ENKTCL cases 10 cases of proliferative lymphadenitis and 10 samples of normal lymph node respectively; The possible role of miR-26a and its target gene CDK6 in genesis and development of ENKTCL were analyzed according to the clinical features of ENKTCL patients; Correlation analysis showed that there was significant negative correlation between miR-26a expression and CDK6 expression r = -0.54 P = 0.04 lymphoma hsa-miR-26b-5p CDK6 -1.21629873619115 0.000852008439136243 0.111940010637567 0.769764850996177 miRNAWalker2_validate;miRTarBase;miRNATAP -0.183573734241083 0.0168872212748234 NA NA NA hsa-miR-29b-3p CDK6 -0.392267406583841 0.343581862655996 0.111940010637567 0.769764850996177 miRNAWalker2_validate;miRTarBase;miRNATAP -0.277686380077038 3.65887844624722e-05 23245396;25472644;26180082;23591808;27230400;20086245 The IFN-γ-induced G1-arrest of melanoma cells involves down-regulation of CDK6 which we proved to be a direct target of miR-29 in these cells;Moreover miR-29b inhibited the expression of MCL1 and CDK6;Knockdown of NTSR1 increased the expression of miR-29b-1 and miR-129-3p which were responsible for the decreased CDK6 expression;Here we have identified the oncogene cyclin-dependent protein kinase 6 CDK6 as a direct target of miR-29b in lung cancer;MiR 29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6; In this study we investigated the role of miR-29b as a novel regulator of CDK6 using bioinformatics methods; We demonstrated that CDK6 can be downregulated by miR-29b via binding to the 3'-UTR region in osteosarcoma cells; Furthermore we identified an inverse correlation between miR-29b and CDK6 protein levels in osteosarcoma tissues; The results revealed that miR-29b acts as a tumor suppressor of osteosarcoma by targeting CDK6 in the proliferation and migration processes;microRNA expression profile and identification of miR 29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma; Furthermore we demonstrate miR-29 inhibition of CDK6 protein and mRNA levels by direct binding to 3'-untranslated region; Inverse correlation between miR-29 and CDK6 was observed in MCL ;;;;; melanoma;colorectal cancer;glioblastoma;lung cancer;sarcoma;lymphoma hsa-miR-29c-3p CDK6 -0.133603914094895 0.743610228811317 0.111940010637567 0.769764850996177 miRNAWalker2_validate;miRTarBase;miRNATAP -0.239764553787496 0.000489205239841677 26396669 Furthermore through qPCR and Western blot assays confirmed that overexpression of miR-29c reduced CDK6 mRNA and protein levels; miR-29c could inhibit the proliferation migration and invasion of bladder cancer cells via regulating CDK6 bladder cancer hsa-miR-3065-5p CDK6 0.744542127327022 0.29683696958743 0.111940010637567 0.769764850996177 mirMAP -0.121454105321263 0.0018613188308513 NA NA NA hsa-miR-30b-5p CDK6 -0.68249444596921 0.0731627218334145 0.111940010637567 0.769764850996177 mirMAP -0.283700064960236 0.000109093184653613 NA NA NA hsa-miR-30c-5p CDK6 -0.877497703999593 0.00776562825190586 0.111940010637567 0.769764850996177 mirMAP -0.193021749510847 0.0246931490773122 NA NA NA hsa-miR-30d-5p CDK6 -0.00941045381462047 0.974732483265334 0.111940010637567 0.769764850996177 mirMAP -0.355774973457398 0.000200483191837229 NA NA NA hsa-miR-32-5p CDK6 -1.1697502932723 0.00457026320106483 0.111940010637567 0.769764850996177 miRNATAP -0.187356113867947 0.0056883629060093 NA NA NA hsa-miR-330-3p CDK6 0.226896608253308 0.63792060187889 0.111940010637567 0.769764850996177 PITA;mirMAP -0.171570184559667 0.00323933169486816 NA NA NA hsa-miR-335-5p CDK6 -0.913728460165869 0.0568330413961764 0.111940010637567 0.769764850996177 mirMAP -0.166058189441693 0.00442497993602396 NA NA NA hsa-miR-338-3p CDK6 0.514743230435341 0.344476371008619 0.111940010637567 0.769764850996177 mirMAP -0.223901200073102 9.94019362052627e-06 NA NA NA hsa-miR-33b-5p CDK6 0.621849465135339 0.329304820187453 0.111940010637567 0.769764850996177 miRNATAP -0.111639941616007 0.0136367432089371 NA NA NA hsa-miR-340-5p CDK6 -0.873554108779771 0.0362049958643107 0.111940010637567 0.769764850996177 mirMAP -0.375311806594757 7.82535891220096e-09 NA NA NA hsa-miR-3613-5p CDK6 -1.57318120093102 0.000766181957603027 0.111940010637567 0.769764850996177 miRNATAP -0.177366806177224 0.00273635998165285 NA NA NA hsa-miR-362-5p CDK6 -0.73199764539445 0.112060703377193 0.111940010637567 0.769764850996177 mirMAP -0.240285851871099 6.68466785557883e-05 NA NA NA hsa-miR-374a-5p CDK6 -0.773847948304864 0.0214475199454759 0.111940010637567 0.769764850996177 mirMAP -0.311015431584939 0.000188619414617607 NA NA NA hsa-miR-374b-5p CDK6 -0.936361879691007 0.00140373477346958 0.111940010637567 0.769764850996177 mirMAP -0.253965620939545 0.00853203512397121 NA NA NA hsa-miR-377-3p CDK6 -1.31382052580179 0.0227530245445242 0.111940010637567 0.769764850996177 mirMAP -0.15540802368208 0.00127430288884364 25577249 microRNA 377 suppresses the proliferation of human osteosarcoma MG 63 cells by targeting CDK6; Our data suggest that miR-377 can suppress proliferation in MG-63 cells in part by targeting CDK6 sarcoma hsa-miR-421 CDK6 -0.177803877528689 0.691941942432956 0.111940010637567 0.769764850996177 mirMAP;miRNATAP -0.171549335092422 0.00679625309372256 NA NA NA hsa-miR-494-3p CDK6 -0.985708010823317 0.085496165859634 0.111940010637567 0.769764850996177 miRTarBase -0.130844382055862 0.00764591255684317 NA NA NA hsa-miR-500a-5p CDK6 -1.10136801235297 0.0179063223236651 0.111940010637567 0.769764850996177 mirMAP -0.182574777217371 0.00232438250477439 NA NA NA hsa-miR-501-3p CDK6 -1.02561651155797 0.004055228716503 0.111940010637567 0.769764850996177 PITA;TargetScan;miRNATAP -0.241283375894772 0.00211114256665944 NA NA NA hsa-miR-539-5p CDK6 -0.736460955018657 0.259965401085259 0.111940010637567 0.769764850996177 mirMAP -0.108725519123002 0.0111337552465868 NA NA NA hsa-miR-582-5p CDK6 -0.241398739931134 0.638696591630038 0.111940010637567 0.769764850996177 miRNATAP -0.189499594062553 0.000484957565749695 NA NA NA hsa-miR-660-5p CDK6 -0.196889121709126 0.556115805668951 0.111940010637567 0.769764850996177 mirMAP -0.299602358895409 0.000395096944237056 NA NA NA hsa-miR-664a-3p CDK6 -0.548519235569408 0.0680199398699682 0.111940010637567 0.769764850996177 mirMAP -0.401945287782489 1.70403706869614e-05 NA NA NA hsa-miR-671-5p CDK6 -0.162477213196106 0.728998069332297 0.111940010637567 0.769764850996177 PITA;miRNATAP -0.177090993074198 0.00322737029407711 NA NA NA hsa-miR-7-1-3p CDK6 -0.729687864305395 0.0834004484481893 0.111940010637567 0.769764850996177 mirMAP -0.222430043215092 0.000809147108421898 NA NA NA hsa-miR-92b-3p CDK6 0.514365666378666 0.186565269716391 0.111940010637567 0.769764850996177 miRNATAP -0.299854064621402 2.77825098983373e-05 NA NA NA hsa-miR-139-5p CDK7 -1.63574949154462 0.00653778531863944 0.385630254730439 0.0731947847764731 miRanda -0.167648359676385 8.45870197541163e-12 NA NA NA hsa-miR-98-5p CDK7 -0.2176359368719 0.422768546610498 0.385630254730439 0.0731947847764731 miRNAWalker2_validate -0.164136495583322 0.00581810444350781 NA NA NA hsa-miR-101-3p CDKN1A -0.269552419431912 0.365715352261274 0.465029563192507 0.171864107125453 MirTarget -0.312613512763375 0.00023280696783799 NA NA NA hsa-miR-106a-5p CDKN1A -1.42646319946109 0.00117400137891297 0.465029563192507 0.171864107125453 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.131964477701327 0.0196046186259036 25510666 After prediction with online software we further used dual-luciferase reporter gene assay to ensure that TP53INP1 and CDKN1A might be the direct targets of miR-106a liver cancer hsa-miR-125a-5p CDKN1A -0.306104092733909 0.370798466662369 0.465029563192507 0.171864107125453 miRNAWalker2_validate;miRTarBase -0.286979942460304 9.03462261473689e-05 NA NA NA hsa-miR-132-3p CDKN1A -0.188684269862105 0.638562246194811 0.465029563192507 0.171864107125453 miRNAWalker2_validate;miRTarBase -0.242349897750116 9.48131544812862e-05 NA NA NA hsa-miR-30b-3p CDKN1A -0.572694191047113 0.234897503722221 0.465029563192507 0.171864107125453 MirTarget -0.127526599140407 0.0142754907595992 NA NA NA hsa-miR-423-3p CDKN1A -1.24108081866902 8.01747949841261e-05 0.465029563192507 0.171864107125453 miRNAWalker2_validate;miRTarBase -0.206298751147157 0.00925982496248602 NA NA NA hsa-miR-491-5p CDKN1A -0.787801664777276 0.12392872487051 0.465029563192507 0.171864107125453 miRanda -0.119489606922327 0.0150734763256775 NA NA NA hsa-miR-582-5p CDKN1A -0.241398739931134 0.638696591630038 0.465029563192507 0.171864107125453 miRNATAP -0.102187223096526 0.0367655161019192 NA NA NA hsa-miR-616-5p CDKN1A -1.29177029725778 0.0104392923321836 0.465029563192507 0.171864107125453 mirMAP -0.104123642074296 0.0357801072207482 NA NA NA hsa-miR-199a-5p CDKN1B -0.208670149801867 0.635984251700429 -0.204859411114938 0.328011811044154 MirTarget;miRanda;miRNATAP -0.109234017310793 0.001621047652019 NA NA NA hsa-miR-199b-5p CDKN1B 0.438479083653495 0.438925410515967 -0.204859411114938 0.328011811044154 MirTarget;miRanda;miRNATAP -0.12128439764607 4.37904691260483e-06 NA NA NA hsa-miR-452-5p CDKN1B -0.155854942382797 0.727558997190393 -0.204859411114938 0.328011811044154 MirTarget -0.110400292795433 0.00121225860470994 24381057 Silencing CDKN1B by small interfering RNA resembled the phenotype resulting from ectopic miR-452 expression liver cancer hsa-miR-107 CDKN1C 0.0358151350299583 0.899122490641298 -0.248818917854925 0.601186648369552 miRanda -0.335943762177295 0.00817373748598442 NA NA NA hsa-miR-320b CDKN1C -0.274329754504576 0.551271682744983 -0.248818917854925 0.601186648369552 miRanda;miRNATAP -0.230015009517469 0.00250555168352199 NA NA NA hsa-miR-590-3p CDKN1C -0.921957466414335 0.0345620969748757 -0.248818917854925 0.601186648369552 miRanda -0.158833343787921 0.048620273394297 NA NA NA hsa-miR-92a-3p CDKN1C -0.417284456385998 0.14690346065742 -0.248818917854925 0.601186648369552 MirTarget;miRNATAP -0.30041037562043 0.015760686637285 NA NA NA hsa-miR-92b-3p CDKN1C 0.514365666378666 0.186565269716391 -0.248818917854925 0.601186648369552 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.199168483760645 0.0282127496425597 NA NA NA hsa-miR-19a-3p CDKN2B -1.39804789764109 0.00390589133951138 -0.628679887399439 0.34299214040031 mirMAP -0.226922765265948 0.0236048885600832 NA NA NA hsa-miR-19b-3p CDKN2B -1.3861807379685 0.00102515671649667 -0.628679887399439 0.34299214040031 mirMAP -0.309876332854068 0.00690653350408446 NA NA NA hsa-miR-330-3p CDKN2B 0.226896608253308 0.63792060187889 -0.628679887399439 0.34299214040031 mirMAP;miRNATAP -0.25323309718003 0.012798042038111 NA NA NA hsa-miR-340-5p CDKN2B -0.873554108779771 0.0362049958643107 -0.628679887399439 0.34299214040031 mirMAP -0.391004922484229 0.000794354944138642 NA NA NA hsa-miR-374b-5p CDKN2B -0.936361879691007 0.00140373477346958 -0.628679887399439 0.34299214040031 miRNAWalker2_validate -0.394578135410229 0.0190552828346126 NA NA NA hsa-miR-501-5p CDKN2B -0.634663345778922 0.169048284923239 -0.628679887399439 0.34299214040031 mirMAP -0.250381143195705 0.0187684544348701 NA NA NA hsa-miR-582-5p CDKN2B -0.241398739931134 0.638696591630038 -0.628679887399439 0.34299214040031 miRNATAP -0.441421884657368 2.16298646023392e-06 NA NA NA hsa-miR-671-5p CDKN2B -0.162477213196106 0.728998069332297 -0.628679887399439 0.34299214040031 PITA -0.406765947372684 8.68478868519689e-05 NA NA NA hsa-miR-7-1-3p CDKN2B -0.729687864305395 0.0834004484481893 -0.628679887399439 0.34299214040031 MirTarget -0.457465577805572 6.73714707600135e-05 NA NA NA hsa-miR-98-5p CDKN2B -0.2176359368719 0.422768546610498 -0.628679887399439 0.34299214040031 miRNAWalker2_validate -0.501591103827223 0.00661741517927437 NA NA NA hsa-miR-146b-5p CDKN2C -1.18658780090466 0.0132247381969501 0.195108774497009 0.491369773331809 miRanda -0.127579130855654 0.00302952356717483 NA NA NA hsa-miR-450b-5p CDKN2C -0.947307681071554 0.0182365957775615 0.195108774497009 0.491369773331809 miRNATAP -0.126654047447139 0.0145645753054087 NA NA NA hsa-miR-125a-5p CDR2L -0.306104092733909 0.370798466662369 1.25667592597505 0.00687762266388074 MirTarget;PITA;miRanda -0.534858659784503 7.0498444875574e-08 NA NA NA hsa-miR-125a-5p CDRT1 -0.306104092733909 0.370798466662369 0.114247907706233 0.89137839040529 miRanda -0.457671911463085 0.0122256007578021 NA NA NA hsa-miR-125a-5p CENPO -0.306104092733909 0.370798466662369 0.261312181164814 0.36646029592422 mirMAP -0.198107357684194 0.00154212095887008 NA NA NA hsa-miR-125a-5p CFLAR -0.306104092733909 0.370798466662369 -0.190881435119482 0.524428417196737 miRanda -0.225724844059335 0.000479179477479602 NA NA NA hsa-miR-125a-5p CGN -0.306104092733909 0.370798466662369 2.89546240762988 4.60337711313969e-06 MirTarget;PITA;miRanda -0.504467738534734 0.000333238714238588 NA NA NA hsa-miR-125a-5p CGNL1 -0.306104092733909 0.370798466662369 -0.0360868399372798 0.941480916958467 miRNAWalker2_validate;miRanda -0.213470251695719 0.0470963860584153 NA NA NA hsa-miR-125a-5p CGREF1 -0.306104092733909 0.370798466662369 1.32120839953594 0.0145591792869539 MirTarget;miRanda -0.473259061662682 5.46188377979528e-05 NA NA NA hsa-miR-139-5p CHEK1 -1.63574949154462 0.00653778531863944 0.947494945808745 0.00606347743770432 miRanda -0.112300520037571 0.00760928526627198 NA NA NA hsa-miR-195-5p CHEK1 -0.685650705852783 0.0717481985943939 0.947494945808745 0.00606347743770432 MirTarget;miRNATAP -0.186885410228045 0.00563229892448278 25840419 MiR 195 suppresses non small cell lung cancer by targeting CHEK1; We discovered that CHEK1 was a direct target of miR-195 which decreased CHEK1 expression in lung cancer cells lung squamous cell cancer hsa-miR-497-5p CHEK1 -0.807147224800789 0.0207081588787015 0.947494945808745 0.00606347743770432 MirTarget;miRNATAP -0.197963096148446 0.0072673359002147 24464213 Checkpoint kinase 1 is negatively regulated by miR 497 in hepatocellular carcinoma; In silico analysis showed that CHEK1 was a candidate target of miR-497 which was previously found to be downregulated in HCC by us; To test whether miR-497 could bind to 3'untranslated region 3'UTR of CHEK1 luciferase reporter assay was conducted; The result revealed that miR-497 could bind to the 3'untranslated region 3'UTR of CHEK1 mRNA; Western blot showed that ectopic expression of miR-497 suppressed the CHEK1 expression and inhibition of miR-497 led to significant upregulation of CHEK1; Finally miR-497 expression was measured in the same 30 HCC samples and the correlation between miR-497 and CHEK1 was analyzed; The results indicated that miR-497 was downregulated in HCC and had a significant negative correlation with CHEK1; Taken together these results demonstrated that CHEK1 was negatively regulated by miR-497 and the overexpressed CHEK1 was resulted from the downregulated miR-497 in HCC which provided a potential molecular target for HCC therapy liver cancer hsa-miR-125a-5p CHRM3 -0.306104092733909 0.370798466662369 0.705778287529687 0.418253739143842 miRanda -0.384892282101025 0.0440375915732896 NA NA NA hsa-miR-125a-5p CIAPIN1 -0.306104092733909 0.370798466662369 0.104215742001697 0.502395186761252 MirTarget -0.152384040117638 2.74906956812064e-06 NA NA NA hsa-miR-125a-5p CKLF -0.306104092733909 0.370798466662369 0.487394897934985 0.171162109956872 miRanda -0.257891633479317 0.000832060157309374 NA NA NA hsa-miR-125a-5p CKS1B -0.306104092733909 0.370798466662369 0.989829471217321 0.0146819235011463 miRanda -0.401406283332178 4.23778737181385e-06 NA NA NA hsa-miR-125a-5p CLDN12 -0.306104092733909 0.370798466662369 1.22604594478576 0.00104965717338898 miRNAWalker2_validate -0.186279341330823 0.0244386880510634 NA NA NA hsa-miR-125a-5p CLDN2 -0.306104092733909 0.370798466662369 3.06817941519802 0.0317204771605238 miRanda -1.24136268487447 6.1579448323587e-05 NA NA NA hsa-miR-125a-5p CLEC2B -0.306104092733909 0.370798466662369 -0.848998268016111 0.0734747792550939 miRanda -0.329416524195807 0.00142723057974578 NA NA NA hsa-miR-125a-5p CLN6 -0.306104092733909 0.370798466662369 0.157654938268204 0.53870257010455 MirTarget;miRanda -0.175504059415217 0.00150883512043939 NA NA NA hsa-miR-125a-5p COL1A2 -0.306104092733909 0.370798466662369 0.24954783677882 0.737225390492558 miRanda -0.489968321000611 0.00244870376369585 NA NA NA hsa-miR-125a-5p COMT -0.306104092733909 0.370798466662369 0.242435262542248 0.342728588524306 mirMAP -0.175480518728097 0.00146196360159518 NA NA NA hsa-miR-125a-5p COQ9 -0.306104092733909 0.370798466662369 0.332882577374384 0.091245524422405 miRanda -0.122304363932329 0.00402241047251889 NA NA NA hsa-miR-125a-5p CORO1C -0.306104092733909 0.370798466662369 -0.174326735767059 0.565009424694849 miRNAWalker2_validate -0.259562958723954 6.46269501826318e-05 NA NA NA hsa-miR-125a-5p CORO2A -0.306104092733909 0.370798466662369 1.63053942298473 0.00807173821845816 MirTarget;miRanda -0.642273950815413 1.2368240034029e-06 NA NA NA hsa-miR-125a-5p CRK -0.306104092733909 0.370798466662369 0.0557360256567678 0.822615390656466 miRNAWalker2_validate -0.185479483197246 0.000517154499690501 NA NA NA hsa-miR-125a-5p CTH -0.306104092733909 0.370798466662369 0.720363773566791 0.13194823515996 miRanda -0.396420379112218 0.000125363553047722 NA NA NA hsa-miR-125a-5p CTNNB1 -0.306104092733909 0.370798466662369 0.0984685073531679 0.665529386385352 miRanda -0.217899848101112 6.51340877859344e-06 NA NA NA hsa-let-7b-3p CUL1 -0.410613874222772 0.167771473653139 0.0159299982280263 0.919471031986822 MirTarget;miRNATAP -0.111545344135215 0.00404642922081619 NA NA NA hsa-let-7b-5p CUL1 0.133031570393829 0.651804468011451 0.0159299982280263 0.919471031986822 miRNAWalker2_validate -0.111913501476374 0.00441402187199964 NA NA NA hsa-miR-125a-5p CYB5B -0.306104092733909 0.370798466662369 0.288350637764633 0.232630865924199 miRanda -0.251601681816989 8.62317726975396e-07 NA NA NA hsa-miR-125a-5p CYBA -0.306104092733909 0.370798466662369 -0.451370943114629 0.424034053549008 miRanda -0.249188627986037 0.0438634738930506 NA NA NA hsa-miR-125a-5p CYTH1 -0.306104092733909 0.370798466662369 -0.595684366199625 0.0311202437784556 MirTarget;miRNATAP -0.181286029869534 0.00256177749468217 NA NA NA hsa-miR-30c-5p DBF4 -0.877497703999593 0.00776562825190586 0.140091764323138 0.594287872175583 MirTarget -0.168395734053237 0.00406280213247014 NA NA NA hsa-miR-98-5p DBF4 -0.2176359368719 0.422768546610498 0.140091764323138 0.594287872175583 miRNAWalker2_validate -0.148739529407267 0.0417658889129193 NA NA NA hsa-miR-125a-5p DECR1 -0.306104092733909 0.370798466662369 -0.200056110478187 0.398306524753587 miRanda -0.117504569416182 0.0221918443728521 NA NA NA hsa-miR-125a-5p DERL3 -0.306104092733909 0.370798466662369 0.431006044362416 0.479609754333902 mirMAP -0.544755680698759 3.26042227306287e-05 NA NA NA hsa-miR-125a-5p DGAT1 -0.306104092733909 0.370798466662369 0.62938719204076 0.0798270822470056 miRNATAP -0.189935044389711 0.0156151560590042 NA NA NA hsa-miR-125a-5p DHFR -0.306104092733909 0.370798466662369 0.424552782937377 0.176751067881631 miRanda -0.236105599982549 0.000509065264568776 NA NA NA hsa-miR-125a-5p DIAPH3 -0.306104092733909 0.370798466662369 1.00775430766924 0.098496821802857 miRanda -0.740658915419091 8.89761714456688e-09 NA NA NA hsa-miR-125a-5p DNAJA4 -0.306104092733909 0.370798466662369 1.1669504680535 0.00386710393916083 miRanda -0.179726715766743 0.0440587440122799 NA NA NA hsa-miR-125a-5p DOK1 -0.306104092733909 0.370798466662369 -0.666849808986713 0.0178872471113997 miRanda -0.199116895897199 0.00114551223526206 NA NA NA hsa-miR-125a-5p DPH2 -0.306104092733909 0.370798466662369 0.160783404569872 0.474200728534942 MirTarget;miRanda;miRNATAP -0.22512017068662 2.18210583408383e-06 NA NA NA hsa-miR-125a-5p DQX1 -0.306104092733909 0.370798466662369 3.4060286909189 0.0173642496060059 miRanda -1.08862183250106 0.000498113082446036 NA NA NA hsa-miR-125a-5p DRAM2 -0.306104092733909 0.370798466662369 -0.460643142373721 0.013517974230411 MirTarget;miRanda;miRNATAP -0.135262435706461 0.000762127987861228 NA NA NA hsa-miR-125a-5p DRP2 -0.306104092733909 0.370798466662369 -0.23720358306455 0.773316444782643 MirTarget -0.929960511026736 9.80656765279052e-08 NA NA NA hsa-miR-125a-5p DSG2 -0.306104092733909 0.370798466662369 1.16025712954129 0.0212669066775823 MirTarget;miRanda -0.263526777500902 0.0173193022342104 NA NA NA hsa-miR-125a-5p DSTN -0.306104092733909 0.370798466662369 0.358179542705646 0.127805768469768 miRanda -0.102984882419634 0.0443341639060402 NA NA NA hsa-miR-125a-5p DTWD1 -0.306104092733909 0.370798466662369 0.161850626015493 0.393735948839715 miRanda -0.109633045800365 0.00725113370841489 NA NA NA hsa-miR-125a-5p DTX4 -0.306104092733909 0.370798466662369 0.426359436662098 0.276825699026349 PITA;miRanda;mirMAP -0.283374150825009 0.000848852392464373 NA NA NA hsa-miR-23b-3p E2F1 0.00716511065069625 0.975265102572651 0.94482859902409 0.0605045283333935 miRNAWalker2_validate -0.448321981810585 0.00753367023558846 NA NA NA hsa-miR-330-3p E2F1 0.226896608253308 0.63792060187889 0.94482859902409 0.0605045283333935 miRNAWalker2_validate;miRTarBase;PITA;miRNATAP -0.225477054588528 0.00348995083270963 19597470 MicroRNA 330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1 mediated suppression of Akt phosphorylation; Bioinformatics analyses reveal a conserved target site for miR-330 in the 3'-untranslated region UTR of E2F1 at nucleotides 1018-1024; In addition the expression level of miR-330 and E2F1 was inversely correlated in cell lines and prostate cancer specimens; Collectively this is the first study to show that E2F1 is negatively regulated by miR-330 and also show that miR-330 induces apoptosis in prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation prostate cancer hsa-miR-342-3p E2F1 -1.50859606438677 0.000361128404069141 0.94482859902409 0.0605045283333935 miRanda -0.214753764340184 0.0136546290746506 26483346 miR 342 3p regulates MYC transcriptional activity via direct repression of E2F1 in human lung cancer lung cancer hsa-miR-98-5p E2F1 -0.2176359368719 0.422768546610498 0.94482859902409 0.0605045283333935 miRNAWalker2_validate -0.369572779033209 0.00862709634953143 NA NA NA hsa-miR-125a-5p E2F2 -0.306104092733909 0.370798466662369 -0.185830986536008 0.73829844769238 MirTarget -0.651340496717978 2.84961220378461e-08 NA NA NA hsa-miR-204-5p E2F2 -1.12734477908708 0.190740222987981 -0.185830986536008 0.73829844769238 mirMAP -0.129995556799299 0.00581462071199797 NA NA NA hsa-miR-301a-3p E2F2 -0.756666069407079 0.0961303802724355 -0.185830986536008 0.73829844769238 miRNATAP -0.291295252299283 0.00118910113888737 NA NA NA hsa-miR-3065-5p E2F2 0.744542127327022 0.29683696958743 -0.185830986536008 0.73829844769238 mirMAP -0.222396285764723 8.09687753274601e-05 NA NA NA hsa-miR-338-3p E2F2 0.514743230435341 0.344476371008619 -0.185830986536008 0.73829844769238 mirMAP -0.253015453510867 0.000701110062501941 NA NA NA hsa-miR-432-5p E2F2 -0.187109431374392 0.743519757702476 -0.185830986536008 0.73829844769238 mirMAP -0.171581638210308 0.0166581448383839 NA NA NA hsa-miR-496 E2F2 -0.263423110562247 0.668883492994483 -0.185830986536008 0.73829844769238 miRanda -0.209111557479811 0.00155051463260042 NA NA NA hsa-miR-539-5p E2F2 -0.736460955018657 0.259965401085259 -0.185830986536008 0.73829844769238 mirMAP -0.196606249919804 0.00154711340540397 NA NA NA hsa-miR-7-5p E2F2 0.818434078643802 0.510587133222615 -0.185830986536008 0.73829844769238 miRNAWalker2_validate -0.219762632506483 1.34321213693023e-09 NA NA NA hsa-miR-98-5p E2F2 -0.2176359368719 0.422768546610498 -0.185830986536008 0.73829844769238 miRNAWalker2_validate;miRTarBase;MirTarget -0.479266836205463 0.00188724733341287 NA NA NA hsa-miR-125a-5p E2F3 -0.306104092733909 0.370798466662369 -0.201785841498038 0.500078226480117 PITA;miRanda;miRNATAP -0.235698886748647 0.000251948836621227 NA NA NA hsa-miR-128-3p E2F3 0.0342813501565651 0.921232054277409 -0.201785841498038 0.500078226480117 miRNAWalker2_validate;miRTarBase -0.267920062504234 2.2174911876198e-05 NA NA NA hsa-miR-141-3p E2F3 1.13131842772144 0.0966666388085424 -0.201785841498038 0.500078226480117 miRNAWalker2_validate;TargetScan;miRNATAP -0.118139908040034 0.000194325368816261 26233544 MiR 141 Inhibits Gastric Cancer Proliferation by Interacting with Long Noncoding RNA MEG3 and Down Regulating E2F3 Expression; QRT-PCR was used to detect miR-141 MEG3 and E2F3 in gastric tissues and cells; Western blot and luciferase activity were used to identify E2F3 as one of the direct targets of miR-141; E2F3 was identified as a target of miR-141 and its inhibition significantly reduced MEG3 expression; E2F3 expression was also found to be negatively associated with both MEG3 and miR-141; E2F3 over-expression partly reversed the changes caused by transfection of miR-141 mimic and inhibition of miR-141 or MEG3 overrides MEG3- or miR-141-induced modulation of cell growth in GC; These findings together suggested that miR-141 could be interacting with MEG3 and targeting E2F3 and these factors may play important anti-tumor effects in GC pathogenesis and provide therapeutic targets in the clinics gastric cancer hsa-miR-15a-5p E2F3 -0.736232967654847 0.0107385113851643 -0.201785841498038 0.500078226480117 miRNATAP -0.260322727049712 0.000676183437205726 NA NA NA hsa-miR-200a-3p E2F3 1.68929243108599 0.00872253595562164 -0.201785841498038 0.500078226480117 miRNATAP -0.12263525012292 0.000238211706330231 NA NA NA hsa-miR-200b-3p E2F3 1.84496256556404 0.00297111610556856 -0.201785841498038 0.500078226480117 miRNAWalker2_validate;miRTarBase;TargetScan -0.111211811143194 0.00134631285804857 22139708;24830600 MicroRNA 200b reverses chemoresistance of docetaxel resistant human lung adenocarcinoma cells by targeting E2F3; We also identified E2F3 as a novel target of miR-200b; Luciferase reporters containing the 3' untranslated region sequence of E2F3 messenger RNA were used to demonstrate that miR-200b could directly target E2F3; Small interfering RNA-mediated E2F3 knockdown revealed similar effects as that of ectopic miR-200b expression; Decreased miR-200b expression was also detected in tumor tissues sampled from lung adenocarcinoma patients treated with docetaxel-based chemotherapy and was proved to be correlated with high expression of E2F3 decreased sensitivity to docetaxel and poor prognosis; Our results suggest that down-regulation of miR-200b could lead to E2F3 overexpression and in turn contribute to chemoresistance of lung adenocarcinoma cells to docetaxel;Previously we have shown that restoration of microRNA miR-200b significantly reverses chemoresistance of human LAD cells by targeting E2F3; HDAC1/4 suppression-induced rescue of miR-200b contributed to downregulation of E2F3 survivin and Aurora-A and upregulation of cleaved-caspase-3 drug resistance;worse prognosis;drug resistance lung cancer;lung cancer hsa-miR-30b-5p E2F3 -0.68249444596921 0.0731627218334145 -0.201785841498038 0.500078226480117 miRNATAP -0.268847164042247 2.09581824375012e-06 NA NA NA hsa-miR-30c-5p E2F3 -0.877497703999593 0.00776562825190586 -0.201785841498038 0.500078226480117 miRNAWalker2_validate;miRNATAP -0.219533576867928 0.000974733196075471 NA NA NA hsa-miR-30d-5p E2F3 -0.00941045381462047 0.974732483265334 -0.201785841498038 0.500078226480117 miRNATAP -0.341119077493728 3.988275374287e-06 NA NA NA hsa-miR-32-5p E2F3 -1.1697502932723 0.00457026320106483 -0.201785841498038 0.500078226480117 miRNAWalker2_validate;miRNATAP -0.11967888663109 0.0242010696770609 NA NA NA hsa-miR-330-3p E2F3 0.226896608253308 0.63792060187889 -0.201785841498038 0.500078226480117 PITA -0.158575597105689 0.000462313394623858 NA NA NA hsa-miR-376a-3p E2F3 -0.604231855167556 0.342794419886032 -0.201785841498038 0.500078226480117 mirMAP -0.107452599757718 0.00189712982322514 NA NA NA hsa-miR-429 E2F3 1.86385884044684 0.00726080911989418 -0.201785841498038 0.500078226480117 PITA;miRanda;miRNATAP -0.124141902931285 5.58451983570988e-05 25953723 MicroRNA 429 suppresses cell proliferation epithelial mesenchymal transition and metastasis by direct targeting of BMI1 and E2F3 in renal cell carcinoma; These results revealed a tumor suppressive role for miR-429 in renal cell carcinoma through directly targeting BMI1 and E2F3 metastasis kidney renal cell cancer hsa-miR-539-5p E2F3 -0.736460955018657 0.259965401085259 -0.201785841498038 0.500078226480117 miRNATAP -0.122244274643805 0.000223373396200718 NA NA NA hsa-miR-628-5p E2F3 -0.849175867924745 0.0241095998555431 -0.201785841498038 0.500078226480117 PITA;miRNATAP -0.247326373466984 1.70870568482466e-05 NA NA NA hsa-miR-7-1-3p E2F3 -0.729687864305395 0.0834004484481893 -0.201785841498038 0.500078226480117 mirMAP -0.225628213713112 1.08413238536051e-05 NA NA NA hsa-miR-744-3p E2F3 -0.545474701469822 0.242282820962622 -0.201785841498038 0.500078226480117 miRNATAP -0.111219248482101 0.0184514246105972 NA NA NA hsa-miR-92b-3p E2F3 0.514365666378666 0.186565269716391 -0.201785841498038 0.500078226480117 miRNATAP -0.229823007471133 3.96552746616919e-05 NA NA NA hsa-miR-23b-3p E2F4 0.00716511065069625 0.975265102572651 0.0453297167323221 0.771304661061863 miRNAWalker2_validate -0.170755392618749 0.000701026245319407 NA NA NA hsa-miR-199a-5p E2F5 -0.208670149801867 0.635984251700429 0.005118387740497 0.987255145241682 miRanda -0.152668260257143 0.00429124694376415 NA NA NA hsa-miR-199b-5p E2F5 0.438479083653495 0.438925410515967 0.005118387740497 0.987255145241682 miRanda -0.15902807151874 0.000103918247249158 NA NA NA hsa-miR-125a-5p E2F7 -0.306104092733909 0.370798466662369 0.868640680694811 0.21579599329517 miRNAWalker2_validate -0.697221849783046 3.51621406599236e-06 NA NA NA hsa-miR-125a-5p EDEM1 -0.306104092733909 0.370798466662369 -0.262497398424022 0.301825109114198 MirTarget;miRanda -0.131002713425567 0.017663791046928 NA NA NA hsa-miR-125a-5p EEF1A1 -0.306104092733909 0.370798466662369 -0.155890318929208 0.522165919836496 miRNAWalker2_validate -0.117064340746844 0.0268036567913713 NA NA NA hsa-miR-125a-5p EGFR -0.306104092733909 0.370798466662369 0.652948123697939 0.253059838344444 mirMAP -0.39241330802723 0.00158135461436912 19881956;27094723;24484870 We report that EGFR signaling leads to transcriptional repression of the miRNA miR-125a through the ETS family transcription factor PEA3;Suppression of microRNA 125a 5p upregulates the TAZ EGFR signaling pathway and promotes retinoblastoma proliferation; Moreover the overexpression of miR-125a-5p led to a decrease in TAZ expression and downstream EGFR signaling pathway activation both in vitro and vivo; Finally TAZ overexpression in retinoblastoma cells overexpressing miR-125a-5p restored retinoblastoma cell proliferation and EGFR pathway activation; Taken together our data demonstrated that miR-125a-5p functions as an important tumor suppressor that suppresses the EGFR pathway by targeting TAZ to inhibit tumor progression in retinoblastoma;miR 125a regulates cell cycle proliferation and apoptosis by targeting the ErbB pathway in acute myeloid leukemia; Profiling revealed the ErbB pathway as significantly decreased with ectopic miR-125a; Either ectopic expression of miR-125a or inhibition of ErbB via Mubritinib resulted in inhibition of cell cycle proliferation and progression with enhanced apoptosis revealing ErbB inhibitors as potential novel therapeutic agents for treating miR-125a-low AML ;progression;progression ovarian cancer;retinoblastoma;acute myeloid leukemia hsa-miR-125a-5p EIF4E2 -0.306104092733909 0.370798466662369 -0.00042478168157789 0.997947848111679 miRanda -0.195739052152232 9.53072138310262e-09 NA NA NA hsa-miR-125a-5p EIF4EBP1 -0.306104092733909 0.370798466662369 0.241267027835637 0.583633698741081 miRNAWalker2_validate;MirTarget;miRanda;miRNATAP -0.39756709433062 2.56849228581643e-05 26646586 Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ovarian cancer hsa-miR-125a-5p ELF4 -0.306104092733909 0.370798466662369 0.208002619334962 0.520160732683123 miRanda -0.139555324123301 0.0480009755025084 NA NA NA hsa-miR-125a-5p ELK1 -0.306104092733909 0.370798466662369 -0.0435991618307101 0.806829705109417 miRanda -0.118113145827261 0.00194703839270432 NA NA NA hsa-miR-125a-5p ELOVL1 -0.306104092733909 0.370798466662369 0.235211976742985 0.367604422059635 PITA;miRanda;miRNATAP -0.292988278632881 9.82359395270407e-08 NA NA NA hsa-miR-125a-5p ELOVL6 -0.306104092733909 0.370798466662369 1.20127761677196 0.00782916950332372 MirTarget;PITA;miRanda -0.265768299435368 0.00742792956592838 NA NA NA hsa-miR-125a-5p EME1 -0.306104092733909 0.370798466662369 0.313226221853964 0.544993396945428 miRanda -0.498546829573322 6.75888043762861e-06 NA NA NA hsa-miR-125a-5p EMILIN2 -0.306104092733909 0.370798466662369 -0.996919719437979 0.0199955824339698 miRanda -0.390084779398376 2.51741436970328e-05 NA NA NA hsa-miR-125a-5p EMX1 -0.306104092733909 0.370798466662369 0.979028111272919 0.431498056731275 mirMAP -0.554990908206914 0.0419689969094868 NA NA NA hsa-miR-125a-5p ENO1 -0.306104092733909 0.370798466662369 -0.0355278416708433 0.917383040019907 miRNAWalker2_validate -0.155051256439033 0.0379139481236157 NA NA NA hsa-miR-106b-5p EP300 -0.814181559290382 0.00942928404699138 -0.139612463725088 0.63275028290479 miRNATAP -0.145600632659923 0.0350826701673532 NA NA NA hsa-miR-149-5p EP300 -0.347157589403708 0.485679492305972 -0.139612463725088 0.63275028290479 miRNAWalker2_validate -0.104869252125561 0.015007328404626 NA NA NA hsa-miR-20a-5p EP300 -0.39483820331792 0.269587643143535 -0.139612463725088 0.63275028290479 miRNATAP -0.163519617944046 0.00682452537784913 NA NA NA hsa-miR-26b-5p EP300 -1.21629873619115 0.000852008439136243 -0.139612463725088 0.63275028290479 miRNAWalker2_validate;miRNATAP -0.226354580173511 8.95139294499492e-05 NA NA NA hsa-miR-30c-5p EP300 -0.877497703999593 0.00776562825190586 -0.139612463725088 0.63275028290479 miRNAWalker2_validate -0.18111275564031 0.00550456471678343 NA NA NA hsa-miR-339-5p EP300 -0.916407842972803 0.0433475651700471 -0.139612463725088 0.63275028290479 miRanda -0.166629648239122 0.000366032239713785 NA NA NA hsa-miR-374b-5p EP300 -0.936361879691007 0.00140373477346958 -0.139612463725088 0.63275028290479 mirMAP;miRNATAP -0.159107811709239 0.0311082496470307 NA NA NA hsa-miR-590-3p EP300 -0.921957466414335 0.0345620969748757 -0.139612463725088 0.63275028290479 MirTarget;PITA;miRanda;mirMAP;miRNATAP -0.10246389779611 0.0373154993372335 NA NA NA hsa-miR-96-5p EP300 -0.14300109523641 0.834020197937914 -0.139612463725088 0.63275028290479 TargetScan;miRNATAP -0.110414602789775 0.000374737215333983 NA NA NA hsa-miR-125a-5p EPHA2 -0.306104092733909 0.370798466662369 1.88837060071538 0.00763113991797444 miRanda -0.479105537658148 0.00203578113813956 NA NA NA hsa-miR-125a-5p ERBB2 -0.306104092733909 0.370798466662369 1.00075047615065 0.0553188910422915 miRNAWalker2_validate -0.529138150172099 2.29192843923766e-06 21220473;26966351 We investigated a tumor inhibitory effect of miR-125a-5p in gastric cancer focusing in particular on the miR-125a-ERBB2 HER2 HER-2/neu pathway; The regulation of ERBB2 by miR-125a-5p was examined with precursor miR-125a-transfected cells; Furthermore we investigated whether miR-125a-5p suppresses proliferation of gastric cancer cells in combination with trastuzumab a monoclonal antibody against ERBB2; In vitro assays showed that ERBB2 is a direct target of miR-125a-5p which potently suppressed the proliferation of gastric cancer cells and interestingly the growth inhibitory effect was enhanced in combination with trastuzumab;Moreover restoration of the expression of ErbB2 and glucose metabolic enzymes in miR-125 pretransfected cells recovered the susceptibility to doxorubicin ; gastric cancer;sarcoma hsa-miR-125a-5p ERBB3 -0.306104092733909 0.370798466662369 3.09334509904019 4.62743683303311e-06 miRNAWalker2_validate;miRanda -0.377339522689755 0.0128387554737825 NA NA NA hsa-miR-125a-5p ERGIC1 -0.306104092733909 0.370798466662369 0.128337575240519 0.587478323331309 miRanda -0.297548237207484 1.40455585874731e-09 NA NA NA hsa-miR-125a-5p ERMN -0.306104092733909 0.370798466662369 -1.12951548551043 0.118647280096164 miRanda -0.38984427060149 0.0139529442011474 NA NA NA hsa-miR-125a-5p ESPL1 -0.306104092733909 0.370798466662369 0.609010419737376 0.299549612132131 miRanda -0.635247995970817 3.63480485041358e-07 NA NA NA hsa-miR-127-3p ESPL1 -0.0349437841134108 0.944205560394057 0.609010419737376 0.299549612132131 miRanda -0.295248624977814 0.000621365438928298 NA NA NA hsa-miR-98-5p ESPL1 -0.2176359368719 0.422768546610498 0.609010419737376 0.299549612132131 MirTarget -0.539240756900994 0.000921146926065075 NA NA NA hsa-miR-125a-5p ESRRA -0.306104092733909 0.370798466662369 0.384236943754209 0.204112958621175 MirTarget;PITA;miRanda;miRNATAP -0.160623781873546 0.014791147467482 NA NA NA hsa-miR-125a-5p ETV6 -0.306104092733909 0.370798466662369 -0.181625199938708 0.407433904606034 MirTarget;PITA;miRanda;miRNATAP -0.218885893486607 2.37145482739041e-06 NA NA NA hsa-miR-125a-5p FAM107B -0.306104092733909 0.370798466662369 -0.219519716015299 0.536488400516979 MirTarget;miRNATAP -0.32592986019819 1.814299882154e-05 NA NA NA hsa-miR-125a-5p FAM129B -0.306104092733909 0.370798466662369 0.580799421810008 0.0846324180152733 mirMAP;miRNATAP -0.258637233194495 0.000389074819969476 NA NA NA hsa-miR-125a-5p FAM89B -0.306104092733909 0.370798466662369 -0.182502443950818 0.501849483533763 miRanda -0.133705042641432 0.0236129722899698 NA NA NA hsa-miR-125a-5p FANCI -0.306104092733909 0.370798466662369 0.670222695298099 0.0837683869450059 miRanda -0.388789237477331 2.75754533050818e-06 NA NA NA hsa-miR-125a-5p FBXO45 -0.306104092733909 0.370798466662369 0.337411484782975 0.0854197258562646 PITA;miRanda -0.100240004200498 0.0182759422192299 NA NA NA hsa-miR-125a-5p FEN1 -0.306104092733909 0.370798466662369 0.43531318798117 0.135020236104471 miRanda -0.196295593329193 0.00187647424849511 NA NA NA hsa-miR-125a-5p FERMT1 -0.306104092733909 0.370798466662369 2.37196538875617 0.00699112838180182 miRNAWalker2_validate -0.989260465415946 1.50907134095182e-07 NA NA NA hsa-miR-125a-5p FGFR2 -0.306104092733909 0.370798466662369 0.426859579955084 0.592166578792305 miRanda;miRNATAP -0.913340396293472 6.10146740178797e-08 NA NA NA hsa-miR-125a-5p FLVCR2 -0.306104092733909 0.370798466662369 -0.928670196136673 0.091331332973674 miRanda -0.247750795017905 0.0402419624683399 NA NA NA hsa-miR-125a-5p FNDC3B -0.306104092733909 0.370798466662369 0.211994506065182 0.568561427034184 PITA;miRanda -0.249672594913417 0.00194792543660722 NA NA NA hsa-miR-125a-5p FOSL2 -0.306104092733909 0.370798466662369 0.140055312822824 0.739529895197248 mirMAP -0.41197258322539 4.64861993631037e-06 NA NA NA hsa-miR-125a-5p FOXD2 -0.306104092733909 0.370798466662369 0.952716626729547 0.0979670141447365 PITA;miRanda -0.362408684013758 0.00394117064965933 NA NA NA hsa-miR-125a-5p FRAT2 -0.306104092733909 0.370798466662369 -0.121782041789918 0.732570026475451 miRanda -0.39385301296461 1.72866880438243e-07 NA NA NA hsa-miR-125a-5p FUT3 -0.306104092733909 0.370798466662369 2.52121265447606 0.0243598229879562 miRanda -1.36209356600863 9.77550438302707e-09 NA NA NA hsa-miR-125a-5p FUT4 -0.306104092733909 0.370798466662369 -0.0863337276296159 0.824343202241198 MirTarget;PITA;miRanda;miRNATAP -0.494318448714329 1.15902616874784e-09 NA NA NA hsa-miR-125b-2-3p FZR1 0.588326920779072 0.241046956193588 0.134744179092792 0.571786135656218 mirMAP -0.184014765596852 4.41923695315498e-08 NA NA NA hsa-miR-125b-5p FZR1 0.3966978923849 0.254597980570568 0.134744179092792 0.571786135656218 mirMAP -0.17993088324876 0.000333286657299462 NA NA NA hsa-miR-146b-3p FZR1 -1.05389869363675 0.0335251655980074 0.134744179092792 0.571786135656218 mirMAP -0.169461033271646 6.90029343461006e-07 NA NA NA hsa-miR-181a-2-3p FZR1 -0.830499848042463 0.0433790852903154 0.134744179092792 0.571786135656218 mirMAP -0.107800699422603 0.0110570212379601 NA NA NA hsa-miR-185-3p FZR1 -0.807260190159478 0.0588027224863732 0.134744179092792 0.571786135656218 mirMAP -0.138904664536269 0.000607482938611736 NA NA NA hsa-miR-326 FZR1 -0.753790048650868 0.139469657871132 0.134744179092792 0.571786135656218 mirMAP -0.139791010978901 3.35030712705736e-05 NA NA NA hsa-miR-125a-5p GABRP -0.306104092733909 0.370798466662369 2.10775864581909 0.180723066719107 miRanda -1.68802553765177 5.07252770963595e-07 NA NA NA hsa-miR-148b-3p GADD45A -0.0990745204340264 0.77230139028333 0.429423308303623 0.164043599444753 MirTarget -0.273958735006313 3.5223689792554e-05 NA NA NA hsa-miR-301a-3p GADD45A -0.756666069407079 0.0961303802724355 0.429423308303623 0.164043599444753 MirTarget;miRNATAP -0.117157096784276 0.0194445863088983 NA NA NA hsa-miR-324-5p GADD45A -0.993343053719004 0.00956564321262937 0.429423308303623 0.164043599444753 miRanda -0.119265984031248 0.0446454156883693 NA NA NA hsa-miR-454-3p GADD45A -1.26819405185127 0.00175657340513321 0.429423308303623 0.164043599444753 MirTarget;miRNATAP -0.154911296533343 0.00528810100733702 NA NA NA hsa-miR-590-3p GADD45A -0.921957466414335 0.0345620969748757 0.429423308303623 0.164043599444753 miRanda;mirMAP -0.123372393979641 0.017748721776921 NA NA NA hsa-miR-181a-5p GADD45G -0.102992950182657 0.777433141199684 0.485171799795139 0.419121173402969 miRNAWalker2_validate -0.726236395549602 6.80988263108931e-10 NA NA NA hsa-miR-1976 GADD45G -1.00359195894566 0.0120372962173742 0.485171799795139 0.419121173402969 MirTarget -0.482884615606752 8.85927092414939e-06 NA NA NA hsa-miR-125a-5p GALNT7 -0.306104092733909 0.370798466662369 0.478110669579041 0.322766366293938 MirTarget;PITA;miRanda -0.43350547276233 3.04367341945292e-05 NA NA NA hsa-miR-125a-5p GATA6 -0.306104092733909 0.370798466662369 0.167087417603968 0.70486724682548 miRanda -0.291373433909597 0.00234126345295037 NA NA NA hsa-miR-125a-5p GBP2 -0.306104092733909 0.370798466662369 -0.0908296539851925 0.839384248963992 miRanda -0.497604529013099 1.56318573711954e-07 NA NA NA hsa-miR-125a-5p GCOM1 -0.306104092733909 0.370798466662369 -0.624835844357466 0.398182864673557 miRanda -0.56705961261071 0.000400955815453753 NA NA NA hsa-miR-125a-5p GGCT -0.306104092733909 0.370798466662369 0.414221908390002 0.105029098275761 miRNAWalker2_validate -0.289895863717196 7.45543280114706e-08 NA NA NA hsa-miR-125a-5p GINS3 -0.306104092733909 0.370798466662369 -0.221387167392504 0.387740759001655 miRanda -0.224018572254622 4.37054931177225e-05 NA NA NA hsa-miR-125a-5p GJB4 -0.306104092733909 0.370798466662369 2.7960213237094 0.0294029754478359 mirMAP -1.44256816143873 1.41786509222282e-07 NA NA NA hsa-miR-125a-5p GMIP -0.306104092733909 0.370798466662369 -0.634453294572389 0.0526617203436904 miRanda;miRNATAP -0.277443161765963 8.6231343297874e-05 NA NA NA hsa-miR-125a-5p GMPPB -0.306104092733909 0.370798466662369 0.199217862834662 0.341461639459166 mirMAP -0.100858547749105 0.0260934308143076 NA NA NA hsa-miR-125a-5p GPATCH2 -0.306104092733909 0.370798466662369 0.265252232875103 0.245022292503688 miRanda -0.124632411158735 0.0116793876506455 NA NA NA hsa-miR-125a-5p GPC4 -0.306104092733909 0.370798466662369 -0.274409529481586 0.547100863431239 MirTarget;PITA;miRanda -0.527861931400892 4.08033339840723e-08 NA NA NA hsa-miR-125a-5p GPR153 -0.306104092733909 0.370798466662369 0.399782101223627 0.40942831194647 miRanda -0.2279498030689 0.0315033983399371 NA NA NA hsa-miR-125a-5p GPR160 -0.306104092733909 0.370798466662369 -0.0527888457142058 0.914509559460902 miRanda -0.326529246124563 0.00222262561995705 NA NA NA hsa-miR-125a-5p GPRIN2 -0.306104092733909 0.370798466662369 0.847137764267792 0.131244979050937 mirMAP -0.30561114187172 0.0128465024121859 NA NA NA hsa-miR-125a-5p GRIP2 -0.306104092733909 0.370798466662369 -0.454043868664715 0.544763809836408 MirTarget -0.323416550979032 0.0489876542744395 NA NA NA hsa-let-7a-3p GSK3B -0.95056529442537 0.00672174661147133 -0.0181540841618721 0.924082667697741 miRNATAP -0.130764884460157 0.000882251453827258 NA NA NA hsa-miR-126-5p GSK3B -1.40161784967373 0.000199780495822923 -0.0181540841618721 0.924082667697741 mirMAP;miRNATAP -0.115847844552094 0.00137621641821595 NA NA NA hsa-miR-19a-3p GSK3B -1.39804789764109 0.00390589133951138 -0.0181540841618721 0.924082667697741 mirMAP -0.121378845750278 1.30451051475592e-05 NA NA NA hsa-miR-19b-3p GSK3B -1.3861807379685 0.00102515671649667 -0.0181540841618721 0.924082667697741 mirMAP -0.149333392704374 2.69951809140233e-06 NA NA NA hsa-miR-26a-5p GSK3B -0.595418372285298 0.0245871761064168 -0.0181540841618721 0.924082667697741 miRNAWalker2_validate;miRNATAP -0.17955738256913 0.000712500423772387 NA NA NA hsa-miR-26b-5p GSK3B -1.21629873619115 0.000852008439136243 -0.0181540841618721 0.924082667697741 miRNATAP -0.178669210102339 1.31342584989222e-06 NA NA NA hsa-miR-29a-3p GSK3B -0.387866348913471 0.226645201041662 -0.0181540841618721 0.924082667697741 miRNATAP -0.104799663056387 0.0168377729030547 NA NA NA hsa-miR-29c-3p GSK3B -0.133603914094895 0.743610228811317 -0.0181540841618721 0.924082667697741 miRNATAP -0.112159030386421 0.000944549845086466 NA NA NA hsa-miR-340-5p GSK3B -0.873554108779771 0.0362049958643107 -0.0181540841618721 0.924082667697741 mirMAP -0.148784376041887 4.89150363475797e-06 NA NA NA hsa-miR-362-5p GSK3B -0.73199764539445 0.112060703377193 -0.0181540841618721 0.924082667697741 miRNATAP -0.131779009561634 8.00288633148559e-06 NA NA NA hsa-miR-374a-5p GSK3B -0.773847948304864 0.0214475199454759 -0.0181540841618721 0.924082667697741 mirMAP -0.107529978764998 0.00943973445409006 NA NA NA hsa-miR-374b-5p GSK3B -0.936361879691007 0.00140373477346958 -0.0181540841618721 0.924082667697741 mirMAP -0.152813311357164 0.00124018640211005 NA NA NA hsa-miR-664a-3p GSK3B -0.548519235569408 0.0680199398699682 -0.0181540841618721 0.924082667697741 mirMAP -0.233945433966076 2.77997720916697e-07 NA NA NA hsa-miR-125a-5p GSS -0.306104092733909 0.370798466662369 0.290533552699263 0.187277471899947 miRanda -0.150163342634631 0.00156165774205688 NA NA NA hsa-miR-125a-5p HAT1 -0.306104092733909 0.370798466662369 0.0537572356944471 0.766005433207127 miRanda -0.105374012364675 0.00655118157527949 NA NA NA hsa-miR-125a-5p HCG26 -0.306104092733909 0.370798466662369 -0.842354776788635 0.0831646543114099 miRanda -0.245797547336301 0.0210800025337566 NA NA NA hsa-miR-125a-5p HCP5 -0.306104092733909 0.370798466662369 -0.577379659170115 0.208136341636873 miRanda -0.422893705547363 1.77252730781581e-05 NA NA NA hsa-miR-125a-5p HEPH -0.306104092733909 0.370798466662369 0.478024212451904 0.436726963395419 miRanda -0.708966800941891 4.92885864962527e-08 NA NA NA hsa-miR-125a-5p HES2 -0.306104092733909 0.370798466662369 0.161624094567737 0.868330853959413 mirMAP -1.12534867721179 4.82561691154911e-08 NA NA NA hsa-miR-125a-5p HK2 -0.306104092733909 0.370798466662369 0.868840949758015 0.245585646899326 miRNAWalker2_validate;miRTarBase;miRanda -0.738546777963434 4.09608769061231e-06 NA NA NA hsa-miR-125a-5p HLA-F -0.306104092733909 0.370798466662369 -0.617651383485073 0.168226424138505 miRanda -0.314162530293909 0.00125459346765081 NA NA NA hsa-miR-125a-5p HLA-H -0.306104092733909 0.370798466662369 -0.0175100475959136 0.958468023479125 miRanda -0.22892656227451 0.0016518918502057 NA NA NA hsa-miR-125a-5p HMBS -0.306104092733909 0.370798466662369 0.459461882859812 0.0910172888526153 miRanda -0.257897218652158 9.12334547400049e-06 NA NA NA hsa-miR-125a-5p HNF1B -0.306104092733909 0.370798466662369 0.987866174890775 0.329094783072922 miRanda -0.951638552716477 1.20950061358662e-05 NA NA NA hsa-miR-125a-5p HNF4G -0.306104092733909 0.370798466662369 1.73423984671398 0.0301806786170898 miRanda -0.822540408908288 1.69420324268333e-06 NA NA NA hsa-miR-125a-5p HOXC4 -0.306104092733909 0.370798466662369 0.414783379990369 0.435579021502214 miRNAWalker2_validate;miRanda -0.549123854202106 1.28951543132864e-06 NA NA NA hsa-miR-125a-5p HSH2D -0.306104092733909 0.370798466662369 0.0544160837539502 0.915126280058332 miRanda -0.486697617241539 8.45321849033738e-06 NA NA NA hsa-miR-125a-5p HSPA5 -0.306104092733909 0.370798466662369 0.496465665102431 0.0783926193601816 miRanda -0.12723164837486 0.0390326312263177 NA NA NA hsa-miR-125a-5p HTATIP2 -0.306104092733909 0.370798466662369 0.665497787629573 0.0464147343776573 miRanda -0.319385144412931 8.44554829599074e-06 NA NA NA hsa-miR-125a-5p IER2 -0.306104092733909 0.370798466662369 0.408002116511212 0.323740789208696 MirTarget;miRanda -0.239464179773677 0.00785126384806808 NA NA NA hsa-miR-125a-5p IGF2BP1 -0.306104092733909 0.370798466662369 0.611964172445328 0.617323947314495 mirMAP -0.548764999610168 0.0408856884778272 NA NA NA hsa-miR-125a-5p IGSF3 -0.306104092733909 0.370798466662369 0.779695107144025 0.140830021890585 miRanda -0.392163033977391 0.000645951186368888 NA NA NA hsa-miR-125a-5p IL15RA -0.306104092733909 0.370798466662369 0.0755559089741995 0.841624395672925 miRanda -0.35580691526726 1.0786613587442e-05 NA NA NA hsa-miR-125a-5p IL17RA -0.306104092733909 0.370798466662369 -0.275324055813838 0.278748637562059 mirMAP -0.110931623557154 0.0450041494415147 NA NA NA hsa-miR-125a-5p IL17RE -0.306104092733909 0.370798466662369 1.50597044849793 0.0101818117834138 miRanda -0.412340262525448 0.00130957442130037 NA NA NA hsa-miR-125a-5p IL17REL -0.306104092733909 0.370798466662369 0.623842879961789 0.569848038400365 mirMAP -0.509982809016573 0.0339271804592571 NA NA NA hsa-miR-125a-5p IL22RA1 -0.306104092733909 0.370798466662369 1.96572664661218 0.0419790455858455 miRanda -0.915810221882351 1.12341271946149e-05 NA NA NA hsa-miR-125a-5p IMPA2 -0.306104092733909 0.370798466662369 0.448066872345742 0.409435958639208 miRanda -0.317552995294085 0.00733269745801636 NA NA NA hsa-miR-125a-5p INF2 -0.306104092733909 0.370798466662369 0.671724996284268 0.15555495358216 miRanda -0.238020171839121 0.0214963774674504 NA NA NA hsa-miR-125a-5p ISY1 -0.306104092733909 0.370798466662369 0.0246007135667217 0.873221438017003 mirMAP -0.151732415954278 2.46308950030937e-06 NA NA NA hsa-miR-125a-5p ITPKB -0.306104092733909 0.370798466662369 -0.757932970362629 0.0205584525463372 mirMAP -0.254624807940052 0.000337400346909301 NA NA NA hsa-miR-125a-5p ITPR3 -0.306104092733909 0.370798466662369 0.60944950772749 0.257197615806159 miRanda -0.520744050486248 6.2485100235416e-06 NA NA NA hsa-miR-125a-5p JPH1 -0.306104092733909 0.370798466662369 2.33528909405886 3.6474070674966e-05 miRanda -0.272533743791751 0.0312945721947647 NA NA NA hsa-miR-125a-5p KCNK2 -0.306104092733909 0.370798466662369 1.4791249933238 0.100156173587957 miRanda -0.66022574694383 0.0007462384384219 NA NA NA hsa-miR-125a-5p KIAA1257 -0.306104092733909 0.370798466662369 1.11678442601522 0.0873583953242823 miRanda -0.311800972582782 0.0297246018618695 NA NA NA hsa-miR-125a-5p KIAA1522 -0.306104092733909 0.370798466662369 1.32760788051572 0.00411218553419785 PITA;miRanda;miRNATAP -0.391179306447821 0.000103491503935407 NA NA NA hsa-miR-125a-5p KIF18B -0.306104092733909 0.370798466662369 0.90761641646621 0.151410521017438 miRanda -0.764942673975083 1.01334939907466e-08 NA NA NA hsa-miR-125a-5p KIF1C -0.306104092733909 0.370798466662369 -0.0750415824135171 0.780895809406277 mirMAP -0.282016273558664 7.80209284165703e-07 NA NA NA hsa-miR-125a-5p KIF20B -0.306104092733909 0.370798466662369 0.46169234543158 0.260121784126201 miRanda -0.236494204495297 0.00813341893972539 NA NA NA hsa-miR-125a-5p KIF23 -0.306104092733909 0.370798466662369 0.818947923346793 0.15625884547248 miRanda -0.718106944063946 3.4465865824551e-09 NA NA NA hsa-miR-125a-5p KRT80 -0.306104092733909 0.370798466662369 1.34787998597225 0.156291496977082 miRanda;mirMAP -0.788592439247342 0.000127241455675775 NA NA NA hsa-miR-125a-5p LACTB -0.306104092733909 0.370798466662369 -0.216307402498025 0.389663384936539 MirTarget;PITA;miRanda -0.342812247765548 3.74379710627442e-11 NA NA NA hsa-miR-125a-5p LAMA4 -0.306104092733909 0.370798466662369 0.759954721156087 0.118005322144162 miRanda -0.218937629956934 0.0400688800629989 NA NA NA hsa-miR-125a-5p LAMC2 -0.306104092733909 0.370798466662369 1.44128350705827 0.133684335677507 MirTarget;miRanda -1.10570907712424 5.94009571924582e-08 NA NA NA hsa-miR-125a-5p LANCL3 -0.306104092733909 0.370798466662369 1.80182818389677 0.00736346002412482 miRanda -0.310295321149673 0.0367494817045912 NA NA NA hsa-miR-125a-5p LATS2 -0.306104092733909 0.370798466662369 -0.247004409302951 0.525337204953715 miRanda -0.183027781042127 0.0311155969549456 NA NA NA hsa-miR-125a-5p LBX2 -0.306104092733909 0.370798466662369 0.283328400580331 0.663119860088879 miRNAWalker2_validate -0.546280522202676 9.81731271172424e-05 NA NA NA hsa-miR-125a-5p LDLRAD2 -0.306104092733909 0.370798466662369 0.221986425702791 0.584337558315706 mirMAP -0.263145592521694 0.00281426771596346 NA NA NA hsa-miR-125a-5p LFNG -0.306104092733909 0.370798466662369 0.72203426329589 0.174351463819202 MirTarget;PITA;miRanda;miRNATAP -0.370424319918219 0.00135090934343415 NA NA NA hsa-miR-125a-5p LGALS4 -0.306104092733909 0.370798466662369 2.54078432986632 0.0604909533345235 miRanda -1.53382909744865 1.03497308514355e-07 NA NA NA hsa-miR-125a-5p LIF -0.306104092733909 0.370798466662369 1.44863366477995 0.0409965627688317 miRNAWalker2_validate;miRanda;mirMAP;miRNATAP -0.410409197348424 0.0082921230219328 25962054 MicroRNA 125a influences breast cancer stem cells by targeting leukemia inhibitory factor receptor which regulates the Hippo signaling pathway breast cancer hsa-miR-125a-5p LIMA1 -0.306104092733909 0.370798466662369 0.56685854734984 0.164437773885505 miRanda -0.287684103642181 0.0011530728901008 NA NA NA hsa-miR-125a-5p LIPH -0.306104092733909 0.370798466662369 2.68833427404787 0.00315021926011654 miRanda -0.937672181552442 1.87347417275564e-06 NA NA NA hsa-miR-125a-5p LMNB1 -0.306104092733909 0.370798466662369 0.209297529517235 0.561419353243846 miRanda -0.306205234557376 7.71008646564223e-05 NA NA NA hsa-miR-125a-5p LPP -0.306104092733909 0.370798466662369 0.0490849759784222 0.928610573266587 mirMAP -0.434715479988924 0.000238578980318073 NA NA NA hsa-miR-125a-5p LRP10 -0.306104092733909 0.370798466662369 0.388201634237082 0.124909860953384 miRanda;mirMAP -0.20626092590277 0.000148917662670169 NA NA NA hsa-miR-125a-5p LRRC8A -0.306104092733909 0.370798466662369 0.851955430690732 0.0588312233044278 miRanda;miRNATAP -0.251515650885406 0.0108367411621176 NA NA NA hsa-miR-125a-5p LRRC8E -0.306104092733909 0.370798466662369 1.39402201548179 0.0377185824087596 miRanda -0.936890209873939 2.04498374544423e-11 NA NA NA hsa-miR-125a-5p LUM -0.306104092733909 0.370798466662369 0.880426261046715 0.21718837073647 miRanda -0.449522821470482 0.00386626090399574 NA NA NA hsa-miR-125a-5p LUZP1 -0.306104092733909 0.370798466662369 0.00862660290715755 0.975081035394446 PITA;miRanda;mirMAP;miRNATAP -0.20607265157815 0.000527087495913995 NA NA NA hsa-miR-125a-5p LYPD6 -0.306104092733909 0.370798466662369 0.452660087117716 0.541313126611364 miRanda -0.600857009435114 0.000175047199947438 NA NA NA hsa-miR-125a-5p LYPLA2 -0.306104092733909 0.370798466662369 0.0593133724713066 0.828184454955942 PITA;mirMAP -0.117784574517916 0.0476748223923226 NA NA NA hsa-miR-185-3p MAD1L1 -0.807260190159478 0.0588027224863732 0.051487156458089 0.867472146216339 MirTarget -0.131797194514052 0.0129732656829046 NA NA NA hsa-miR-139-5p MAD2L1 -1.63574949154462 0.00653778531863944 0.815296883208637 0.0610198099088697 miRanda -0.188794077534737 0.000315677340087986 NA NA NA hsa-miR-125a-5p MALL -0.306104092733909 0.370798466662369 2.00092682866328 0.00508617362810857 miRanda -0.566234453049324 0.000286128540127452 NA NA NA hsa-miR-125a-5p MAPKAPK2 -0.306104092733909 0.370798466662369 -0.108697028756177 0.572018748814503 MirTarget;mirMAP -0.177732345020852 1.26876087684407e-05 NA NA NA hsa-miR-125a-5p MARVELD1 -0.306104092733909 0.370798466662369 0.153826779163984 0.689494286993948 mirMAP -0.260351346053377 0.00180674854610186 NA NA NA hsa-miR-125a-5p MBNL3 -0.306104092733909 0.370798466662369 -0.264081139480134 0.671031345826238 miRNATAP -0.358268526838187 0.00822302499138728 NA NA NA hsa-miR-125a-5p MCL1 -0.306104092733909 0.370798466662369 -0.0639070400574671 0.812622066363974 MirTarget;PITA;miRanda -0.213944664466556 0.000218940335510416 NA NA NA hsa-miR-139-5p MCM2 -1.63574949154462 0.00653778531863944 0.253483627264003 0.529546811106686 miRanda -0.171469430575849 0.000390776392970645 NA NA NA hsa-miR-99b-5p MCM3 -0.421479237940115 0.198329164031546 0.173289911014765 0.500728010284714 miRNAWalker2_validate -0.184119718237012 0.00150055825716195 NA NA NA hsa-miR-129-5p MCM4 1.01348286569596 0.367116067584743 0.474162506707497 0.229195685224971 miRanda -0.115757390726712 4.16661631229443e-06 NA NA NA hsa-miR-338-3p MCM4 0.514743230435341 0.344476371008619 0.474162506707497 0.229195685224971 MirTarget;miRanda -0.246304519333591 2.33376238516935e-06 NA NA NA hsa-miR-330-3p MCM5 0.226896608253308 0.63792060187889 -0.353698702184747 0.262747129456078 miRNATAP -0.174885461874277 0.000254055873727016 NA NA NA hsa-miR-654-5p MCM5 -0.424188362778671 0.457855106854761 -0.353698702184747 0.262747129456078 miRNATAP -0.162341759239036 5.25206343500347e-05 NA NA NA hsa-miR-1180-3p MCM6 1.10236023890635 0.0606548714992848 0.233975335433994 0.388962860799484 miRNAWalker2_validate -0.138429653071064 3.03358538779164e-05 NA NA NA hsa-miR-329-3p MCM6 -0.894877176762194 0.128468159183755 0.233975335433994 0.388962860799484 MirTarget -0.121003604453705 0.000339145392910497 NA NA NA hsa-miR-369-3p MCM6 -0.832959746953411 0.173640923390195 0.233975335433994 0.388962860799484 mirMAP -0.119759790280159 0.000187391851117179 NA NA NA hsa-miR-429 MCM6 1.86385884044684 0.00726080911989418 0.233975335433994 0.388962860799484 miRanda -0.108776751544364 0.000101185250223198 NA NA NA hsa-miR-485-3p MCM6 -1.07524599303664 0.0567048241974248 0.233975335433994 0.388962860799484 MirTarget -0.139696536989777 5.48906928685566e-05 NA NA NA hsa-miR-7-1-3p MCM6 -0.729687864305395 0.0834004484481893 0.233975335433994 0.388962860799484 mirMAP -0.149848959897639 0.0014636823983549 NA NA NA hsa-miR-125a-5p MEMO1 -0.306104092733909 0.370798466662369 -0.242357316473695 0.230158027685266 miRanda -0.14036258746331 0.00121431469535396 NA NA NA hsa-miR-125a-5p MEOX2 -0.306104092733909 0.370798466662369 -0.263796536592233 0.740621490793966 miRanda -0.568573721770544 0.00100858477962152 NA NA NA hsa-miR-125a-5p MEX3A -0.306104092733909 0.370798466662369 -0.534052474181034 0.247819564683994 PITA -0.298844335360896 0.00295722902673665 NA NA NA hsa-miR-125a-5p MFHAS1 -0.306104092733909 0.370798466662369 -0.328525301003352 0.470686929883332 MirTarget;PITA;miRanda;miRNATAP -0.364242154287755 0.000211400950444848 NA NA NA hsa-miR-125a-5p MFN1 -0.306104092733909 0.370798466662369 -0.156592424828218 0.423722284026974 miRanda -0.161100213579647 0.000112092270378231 NA NA NA hsa-miR-125a-5p MGLL -0.306104092733909 0.370798466662369 1.01137912570225 0.0353166946446557 mirMAP -0.455874820771892 1.06265869806296e-05 NA NA NA hsa-miR-125a-5p MGST1 -0.306104092733909 0.370798466662369 1.97531361501911 0.0195690498411061 miRanda -1.01510971410117 1.62793095496762e-08 NA NA NA hsa-miR-125a-5p MICAL2 -0.306104092733909 0.370798466662369 0.230347420840419 0.584731230990915 miRanda -0.335533899090423 0.000224448885301642 NA NA NA hsa-miR-125a-5p MLX -0.306104092733909 0.370798466662369 0.337114305873659 0.057875216195462 MirTarget -0.125064778454372 0.00103771540195226 NA NA NA hsa-miR-125a-5p MMP11 -0.306104092733909 0.370798466662369 0.390239113527045 0.714521516693158 miRNAWalker2_validate;miRTarBase;MirTarget;miRanda;miRNATAP -0.680683626968485 0.00338691019170086 22768249 Ectopic expression of MiR 125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF; Furthermore miR-125a expression was inversely correlated with both MMP11 and VEGF-A expression in HCC tissues; MiR-125a inhibits the proliferation and metastasis of HCC by targeting MMP11 and VEGF-A metastasis liver cancer hsa-miR-125a-5p MMP14 -0.306104092733909 0.370798466662369 0.131775730199447 0.823779807226411 mirMAP -0.548817770601736 1.53381010811028e-05 NA NA NA hsa-miR-125a-5p MMP2 -0.306104092733909 0.370798466662369 0.132076740355265 0.864609923378351 miRanda -0.704471882111743 2.3072477204421e-05 NA NA NA hsa-miR-125a-5p MMP28 -0.306104092733909 0.370798466662369 1.93088043079523 0.00595943965853115 miRanda -0.41133191415295 0.00782852082402238 NA NA NA hsa-miR-125a-5p MORC2 -0.306104092733909 0.370798466662369 0.289868202242507 0.129598217165823 miRNAWalker2_validate -0.14544546735283 0.000381701567585658 NA NA NA hsa-miR-125a-5p MPDU1 -0.306104092733909 0.370798466662369 -0.0362428445412935 0.883626764466867 miRanda -0.135588293692251 0.0114448695548083 NA NA NA hsa-miR-125a-5p MR1 -0.306104092733909 0.370798466662369 -0.0984441358151158 0.779530641227399 mirMAP -0.332055435569668 9.90159116537079e-06 NA NA NA hsa-miR-125a-5p MREG -0.306104092733909 0.370798466662369 -0.0457603698701106 0.873494095011704 miRanda -0.183891154607704 0.00310076062989162 NA NA NA hsa-miR-125a-5p MRPL11 -0.306104092733909 0.370798466662369 0.302099781516548 0.207610268405352 miRanda -0.171405734254934 0.000908034146409236 NA NA NA hsa-miR-125a-5p MRPL15 -0.306104092733909 0.370798466662369 0.315315377347514 0.194018510365479 miRanda -0.24384941691508 2.22700559580666e-06 NA NA NA hsa-miR-125a-5p MRPL30 -0.306104092733909 0.370798466662369 0.141311407601415 0.285867481271395 miRanda -0.104677133493334 0.000163779088982901 NA NA NA hsa-miR-125a-5p MRPL50 -0.306104092733909 0.370798466662369 0.204780980069296 0.292580501927102 miRNAWalker2_validate -0.129543163307822 0.00193022628216955 NA NA NA hsa-miR-125a-5p MRPL9 -0.306104092733909 0.370798466662369 0.210108369360475 0.316236210152909 miRanda -0.105365573832419 0.0201888531581687 NA NA NA hsa-miR-125a-5p MRPS10 -0.306104092733909 0.370798466662369 0.206447866576769 0.311633720372999 miRanda -0.186018172615062 1.76910328919585e-05 NA NA NA hsa-miR-125a-5p MUC2 -0.306104092733909 0.370798466662369 3.54167800045476 0.0962176412926782 miRanda -1.69584759324012 0.000244428663937729 NA NA NA hsa-miR-125a-5p MUC5B -0.306104092733909 0.370798466662369 4.29448092296217 0.0050239900734886 miRanda -1.51472142929979 4.83075053984404e-06 NA NA NA hsa-miR-429 MYC 1.86385884044684 0.00726080911989418 -0.178059728118672 0.681016800198706 miRNAWalker2_validate -0.192503787528237 1.56824075580799e-05 21684154;24633485 miR 429 modulates the expression of c myc in human gastric carcinoma cells; SGC-7901 gastric cancer cells were transfected with miR-429 mimics and endogenous c-myc expression was detected by western blots; We performed functional assays using the 3'UTR of the c-myc gene as a miR-429 target in a luciferase reporter assay system; miR-429 significantly downregulated endogenous c-myc expression in SGC-7901 cells; Action of miR/429 on c-myc 3'UTR was confirmed; c-myc is an important miR-429 target gene;It is known that miR-429 is down-regulated and functions as a tumor suppressor by targeting c-myc and PLGG1 in gastric and breast cancer ; gastric cancer;sarcoma hsa-miR-744-5p MYC -0.595778447321061 0.172283646202662 -0.178059728118672 0.681016800198706 miRNAWalker2_validate -0.245764050284907 0.000724219709081621 24991193 Decrease expression of microRNA 744 promotes cell proliferation by targeting c Myc in human hepatocellular carcinoma; Quantitative reverse-transcription polymerase chain reaction qRT-PCR was conducted to detect the expression of miR-744 and Immunohistochemistry was performed to detect expression of c-Myc in HCC specimens and adjacent normal tissues; Luciferase reporter assays was performed to confirm whether miR-744 regulated the expression of c-Myc; Luciferase assay and Western blot analysis revealed that c-Myc is a direct target of miR-744; Down-regulation of miR-744 and up-regulation of c-Myc were detected in HCC specimens compared with adjacent normal tissues; Moreover restoration of miR-744 rescues c-Myc induced HCC proliferation; Our data suggest that miR-744 exerts its tumor suppressor function by targeting c-Myc leading to the inhibition of HCC cell growth liver cancer hsa-miR-98-5p MYC -0.2176359368719 0.422768546610498 -0.178059728118672 0.681016800198706 miRNAWalker2_validate;miRTarBase -0.243998943583724 0.0435924756865075 NA NA NA hsa-miR-125a-5p MYEOV -0.306104092733909 0.370798466662369 5.12849220867701 0.000151860233441864 miRanda -2.08352438673274 1.69422669233464e-13 NA NA NA hsa-miR-125a-5p NAGA -0.306104092733909 0.370798466662369 -0.146728559158367 0.465042484601224 miRanda -0.151651303308485 0.00041548563707499 NA NA NA hsa-miR-125a-5p NET1 -0.306104092733909 0.370798466662369 0.907020185816962 0.0412284647005201 miRanda -0.383880154200134 6.47689880940029e-05 NA NA NA hsa-miR-125a-5p NFIB -0.306104092733909 0.370798466662369 -0.279377796635174 0.482531004584285 PITA;miRNATAP -0.232925946365436 0.00713580357803387 NA NA NA hsa-miR-125a-5p NFKBIE -0.306104092733909 0.370798466662369 -0.795123298999537 0.0306107809476775 miRanda -0.32459577997774 4.35566267407696e-05 NA NA NA hsa-miR-125a-5p NKIRAS2 -0.306104092733909 0.370798466662369 0.146934812129423 0.383864314685387 miRanda -0.104738921433265 0.00371303020938273 NA NA NA hsa-miR-125a-5p NLRC5 -0.306104092733909 0.370798466662369 -0.819381157207098 0.0492287388457789 miRanda -0.257545354733237 0.00466203059863541 NA NA NA hsa-miR-125a-5p NME2 -0.306104092733909 0.370798466662369 0.397316074746399 0.223849112657653 miRNAWalker2_validate -0.250192785917366 0.00039009474624073 NA NA NA hsa-miR-125a-5p NME2P1 -0.306104092733909 0.370798466662369 0.159702542165384 0.749810888765465 miRanda -0.332418885779511 0.0022369619259718 NA NA NA hsa-miR-125a-5p NMI -0.306104092733909 0.370798466662369 -0.0838585705280526 0.789854059526106 miRanda -0.346174102988524 1.90791103246092e-07 NA NA NA hsa-miR-125a-5p NOB1 -0.306104092733909 0.370798466662369 0.205232233020348 0.389956218005448 miRanda -0.248702041594193 8.28880410838124e-07 NA NA NA hsa-miR-125a-5p NOP16 -0.306104092733909 0.370798466662369 0.554812192793118 0.0451985286060745 miRNAWalker2_validate -0.265925047232902 7.32187638276067e-06 NA NA NA hsa-miR-125a-5p NOS1AP -0.306104092733909 0.370798466662369 1.16113143046355 0.0461582036193601 miRanda -0.2683306891971 0.0361444061393473 NA NA NA hsa-miR-125a-5p NOTCH2 -0.306104092733909 0.370798466662369 -1.04731981186296 0.0348938545789631 miRanda -0.411944636666046 0.000130028611333153 NA NA NA hsa-miR-125a-5p NOTCH2NL -0.306104092733909 0.370798466662369 -0.522690207624395 0.320989645622678 miRanda -0.520132518352948 3.90359668216417e-06 NA NA NA hsa-miR-125a-5p NPL -0.306104092733909 0.370798466662369 -1.56797839708408 0.000537718421095356 MirTarget;PITA;miRanda -0.345354578556383 0.000523105787171409 NA NA NA hsa-miR-125a-5p NR2C2AP -0.306104092733909 0.370798466662369 0.303307169577654 0.224228287842022 miRanda -0.176598457854656 0.00103649131280265 NA NA NA hsa-miR-125a-5p NRBF2 -0.306104092733909 0.370798466662369 -0.101784252528596 0.532067200252722 miRanda -0.145828700364601 2.15092109907437e-05 NA NA NA hsa-miR-125a-5p NRM -0.306104092733909 0.370798466662369 -0.260271062296843 0.400075475498072 miRNATAP -0.330263082718593 4.6632431505806e-07 NA NA NA hsa-miR-125a-5p NT5E -0.306104092733909 0.370798466662369 0.948565287990109 0.120662029961088 miRanda -0.575482012388516 1.19835176652279e-05 NA NA NA hsa-miR-125a-5p NUDT16P1 -0.306104092733909 0.370798466662369 0.539957720402978 0.0811166134812697 miRanda -0.152939054606396 0.023777337216172 NA NA NA hsa-miR-125a-5p OAS3 -0.306104092733909 0.370798466662369 0.0976443592831329 0.847222279055087 mirMAP -0.350153126912823 0.00144556126077427 NA NA NA hsa-miR-125a-5p OTUB2 -0.306104092733909 0.370798466662369 0.749969576383675 0.0676898437236786 miRNAWalker2_validate;miRanda -0.345535840180457 9.84130844198258e-05 NA NA NA hsa-miR-125a-5p OVOL1 -0.306104092733909 0.370798466662369 2.7046709291693 0.0117703726262395 MirTarget -1.14537273812973 6.86117656745075e-07 NA NA NA hsa-miR-125a-5p PADI2 -0.306104092733909 0.370798466662369 -1.23463181855559 0.0610688955233953 miRanda -0.30249783905927 0.0368659510653908 NA NA NA hsa-miR-125a-5p PANX1 -0.306104092733909 0.370798466662369 0.180370182548932 0.534475724870803 miRNAWalker2_validate;miRanda -0.167168131349271 0.0079721896139742 NA NA NA hsa-miR-125a-5p PARP14 -0.306104092733909 0.370798466662369 -0.368417684303843 0.28334379912382 MirTarget;miRanda;miRNATAP -0.149880737629558 0.0458036431417934 NA NA NA hsa-miR-125a-5p PCGF6 -0.306104092733909 0.370798466662369 -0.12014571510651 0.561254857523751 MirTarget;miRanda -0.128574359356323 0.00386666491921726 NA NA NA hsa-miR-125a-5p PCSK7 -0.306104092733909 0.370798466662369 0.068559924803913 0.791690194835159 MirTarget;PITA;miRanda -0.111992522261975 0.0472679131254456 NA NA NA hsa-miR-125a-5p PCTP -0.306104092733909 0.370798466662369 0.196545730918587 0.438460983337733 MirTarget;PITA;miRanda;miRNATAP -0.260211030487194 1.28040836937676e-06 NA NA NA hsa-miR-125a-5p PDCL3 -0.306104092733909 0.370798466662369 -0.0758888357875032 0.675518188717255 miRNAWalker2_validate -0.100802845503261 0.00964645231494869 NA NA NA hsa-miR-125a-5p PDGFRA -0.306104092733909 0.370798466662369 -0.0894156265824781 0.883048801530983 miRanda -0.341441143577024 0.00999991715525459 NA NA NA hsa-miR-125a-5p PDXDC1 -0.306104092733909 0.370798466662369 0.691019411731784 0.00740404185964031 miRanda -0.241901772241467 1.31124169259771e-05 NA NA NA hsa-miR-125a-5p PES1 -0.306104092733909 0.370798466662369 0.131723168994134 0.564085264216354 PITA;miRanda -0.14689279580084 0.00284502859505838 NA NA NA hsa-miR-125a-5p PGM3 -0.306104092733909 0.370798466662369 0.138054503392333 0.641157463555808 miRNAWalker2_validate -0.25073487309669 7.91336508380724e-05 NA NA NA hsa-miR-125a-5p PI16 -0.306104092733909 0.370798466662369 -0.425641620208035 0.761116934115996 miRanda -0.639635089162987 0.037009070231921 NA NA NA hsa-miR-125a-5p PKP1 -0.306104092733909 0.370798466662369 0.276617189272345 0.805297316941337 MirTarget -0.870500490830113 0.000338895617848513 NA NA NA hsa-miR-125a-5p PKP4 -0.306104092733909 0.370798466662369 0.640888143454394 0.003922575079262 miRanda -0.115263029636362 0.0177593351300924 NA NA NA hsa-miR-125a-5p PLA2G4F -0.306104092733909 0.370798466662369 2.80354380722847 0.00481184413798196 miRNAWalker2_validate -1.08216232893357 4.16034602864648e-07 NA NA NA hsa-miR-125a-5p PLAU -0.306104092733909 0.370798466662369 0.144116917825932 0.84718218332279 miRanda -0.488101086924891 0.00268951270887185 NA NA NA hsa-miR-125a-5p PLCB3 -0.306104092733909 0.370798466662369 0.657871098433537 0.126379802539002 miRanda -0.360985125848128 0.000102697285162461 NA NA NA hsa-miR-125a-5p PLEKHA8 -0.306104092733909 0.370798466662369 0.0714410084423216 0.770493973175219 miRanda -0.148229761603451 0.00509188498287223 NA NA NA hsa-miR-125a-5p PLIN3 -0.306104092733909 0.370798466662369 0.0349483523457064 0.916021099377688 miRanda -0.319962615836535 5.97359395319571e-06 NA NA NA hsa-miR-874-3p PLK1 -0.134091707830919 0.772470526227307 1.16011197324199 0.035480061086793 miRNAWalker2_validate -0.355706093973328 4.54094062150043e-05 NA NA NA hsa-miR-125a-5p PLS3 -0.306104092733909 0.370798466662369 -0.0354116907212489 0.910913113889832 miRNAWalker2_validate;miRanda -0.281239327813696 3.31519299730716e-05 NA NA NA hsa-miR-125a-5p PML -0.306104092733909 0.370798466662369 -0.0839446121789509 0.778726861490104 miRanda -0.18798205764543 0.00366599321868566 NA NA NA hsa-miR-125a-5p PMM2 -0.306104092733909 0.370798466662369 0.577722356896087 0.0231945275252442 MirTarget;miRanda -0.375003823487554 7.11072963387444e-13 NA NA NA hsa-miR-125a-5p POLG -0.306104092733909 0.370798466662369 -0.142099427201301 0.473921162870493 miRanda -0.181794572213566 1.55210327561394e-05 NA NA NA hsa-miR-125a-5p POU2F3 -0.306104092733909 0.370798466662369 0.781608409122668 0.471399287679095 miRanda -0.769719181106539 0.00109541429866595 NA NA NA hsa-miR-125a-5p PPFIBP2 -0.306104092733909 0.370798466662369 -0.0739941621235953 0.842914664932597 miRanda -0.278476264422444 0.000554304642193072 NA NA NA hsa-miR-125a-5p PPIA -0.306104092733909 0.370798466662369 0.208881160160217 0.3926812423628 miRanda -0.235871217504494 5.58290022022426e-06 NA NA NA hsa-miR-125a-5p PPIF -0.306104092733909 0.370798466662369 0.0383350664868161 0.906076217792278 MirTarget;miRanda -0.232527583227849 0.000921115374148433 NA NA NA hsa-miR-125a-5p PPP1CA -0.306104092733909 0.370798466662369 0.0647425452736297 0.784838677299468 miRanda;miRNATAP -0.192678788313404 0.000146720771318611 NA NA NA hsa-miR-125a-5p PPRC1 -0.306104092733909 0.370798466662369 0.157043155364858 0.444872990938118 miRanda -0.153025883541549 0.000508690823531551 NA NA NA hsa-miR-125a-5p PRC1 -0.306104092733909 0.370798466662369 0.961410515814134 0.0301760525325305 miRNAWalker2_validate -0.454054891128329 1.79827807076842e-06 NA NA NA hsa-miR-125a-5p PRELID2 -0.306104092733909 0.370798466662369 1.04208836432176 0.0189913518133691 miRanda -0.351038981105657 0.000279743167082794 NA NA NA hsa-miR-101-5p PRKDC -0.699849074885007 0.0367852250865455 0.0585738052509326 0.835451076181594 miRNAWalker2_validate;miRTarBase -0.184358401178429 0.00293505673502347 22014955 Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299 H1975 and A549 cells it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells lung squamous cell cancer hsa-miR-125a-5p PSAPL1 -0.306104092733909 0.370798466662369 3.08512633488589 0.0788287423501629 miRanda -1.18498241640381 0.00199528213776922 NA NA NA hsa-miR-125a-5p PSMB8 -0.306104092733909 0.370798466662369 -0.148467713535607 0.660771745045835 MirTarget;miRanda;miRNATAP -0.394257943797878 3.0532577845173e-08 NA NA NA hsa-miR-125a-5p PSMB9 -0.306104092733909 0.370798466662369 -0.446002590000008 0.355644829477128 miRanda -0.476757742291488 3.86975461525692e-06 NA NA NA hsa-miR-125a-5p PSMD13 -0.306104092733909 0.370798466662369 0.125417352912915 0.603901441073428 miRanda -0.179786128172424 0.000537798324154336 NA NA NA hsa-miR-125a-5p PSMD14 -0.306104092733909 0.370798466662369 0.384464057733329 0.0704028236813877 miRanda -0.158627425186754 0.000521349152355255 NA NA NA hsa-miR-125a-5p PSMD7 -0.306104092733909 0.370798466662369 0.186562747377982 0.280703496388815 miRanda;miRNATAP -0.202187206118019 1.77879782724518e-08 NA NA NA hsa-miR-125a-5p PSMG3 -0.306104092733909 0.370798466662369 0.503427451158116 0.15362958929505 MirTarget;miRanda -0.196214886775084 0.0107763094903876 NA NA NA hsa-miR-125a-5p PTPN2 -0.306104092733909 0.370798466662369 -0.126697962292758 0.542568032850211 miRanda -0.12864196578408 0.00408145184295371 NA NA NA hsa-miR-125a-5p PTPRE -0.306104092733909 0.370798466662369 -0.239669433111565 0.44128607237307 miRanda -0.207544146478943 0.00207053689244936 NA NA NA hsa-miR-125a-5p RAB25 -0.306104092733909 0.370798466662369 2.99388293145619 0.000104292485428396 miRanda -0.661337046203053 9.86219949500537e-05 NA NA NA hsa-miR-125a-5p RABGAP1L -0.306104092733909 0.370798466662369 0.180987050020928 0.51624680765583 miRanda -0.123713684001873 0.0415693969460651 NA NA NA hsa-miR-125a-5p RACGAP1 -0.306104092733909 0.370798466662369 0.694770404520473 0.0612345237653846 miRanda -0.365473817734311 4.33637065300602e-06 NA NA NA hsa-let-7a-3p RAD21 -0.95056529442537 0.00672174661147133 0.215731759997845 0.395441412148044 miRNATAP -0.162717687987066 0.00210414155899975 NA NA NA hsa-miR-125a-5p RAP1A -0.306104092733909 0.370798466662369 -0.452278079062808 0.0555264027151582 miRanda -0.10612174894662 0.0394057408347225 NA NA NA hsa-miR-125a-5p RAPGEF5 -0.306104092733909 0.370798466662369 -0.465427651628724 0.169052915670521 MirTarget;PITA;miRanda -0.162270608567772 0.0281894435622993 NA NA NA hsa-miR-125a-5p RARRES1 -0.306104092733909 0.370798466662369 0.0664881878758887 0.929386437260222 miRanda -0.770880466169655 1.45802082238023e-06 NA NA NA hsa-miR-125a-5p RASAL1 -0.306104092733909 0.370798466662369 1.75702284386932 0.0485942242227164 miRanda -0.96018289672347 4.66840146255158e-07 NA NA NA hsa-miR-125a-5p RASD2 -0.306104092733909 0.370798466662369 1.32491776527777 0.00786831485731443 miRanda;mirMAP -0.444542103168147 3.95811564091459e-05 NA NA NA hsa-let-7f-5p RB1 0.0113289802203234 0.97856356206225 -0.266443624113218 0.30433261559944 miRNATAP -0.115542446223306 0.0108656142652652 NA NA NA hsa-let-7g-5p RB1 -0.81305426635392 0.0157922690810057 -0.266443624113218 0.30433261559944 miRNATAP -0.143885415655138 0.0112952846508387 NA NA NA hsa-miR-200b-3p RBL1 1.84496256556404 0.00297111610556856 -0.227192578431751 0.615851118857476 MirTarget -0.178690710523851 0.000675716967450233 NA NA NA hsa-miR-200c-3p RBL1 1.55610325614114 0.0126526013557324 -0.227192578431751 0.615851118857476 MirTarget -0.135871143095833 0.0101464701480346 NA NA NA hsa-miR-340-5p RBL1 -0.873554108779771 0.0362049958643107 -0.227192578431751 0.615851118857476 mirMAP -0.274883488110631 0.000531064272821504 NA NA NA hsa-miR-429 RBL1 1.86385884044684 0.00726080911989418 -0.227192578431751 0.615851118857476 MirTarget -0.191066406678872 4.34595993851907e-05 NA NA NA hsa-miR-125a-5p RBM41 -0.306104092733909 0.370798466662369 0.381152243176602 0.195471620356985 miRanda -0.138965086758927 0.0304743135906858 NA NA NA hsa-miR-125a-5p RBM7 -0.306104092733909 0.370798466662369 -0.0492882628723486 0.825716514045898 MirTarget;PITA;miRanda;miRNATAP -0.113376352811476 0.0192453924008061 NA NA NA hsa-miR-125a-5p RBM8A -0.306104092733909 0.370798466662369 0.256843462321877 0.177159729673433 PITA -0.117344726597698 0.00416999222833026 NA NA NA hsa-miR-125a-5p RBPMS -0.306104092733909 0.370798466662369 -0.267187184609952 0.414793737608742 PITA;miRanda -0.319505572728179 4.82957552451323e-06 NA NA NA hsa-miR-125a-5p RCAN1 -0.306104092733909 0.370798466662369 -0.0232826211455315 0.946356532016053 miRanda -0.148953754071612 0.0485592039003786 NA NA NA hsa-miR-125a-5p RCE1 -0.306104092733909 0.370798466662369 0.290085392682649 0.209856338029125 miRanda -0.162364759975884 0.00112511283271646 NA NA NA hsa-miR-125a-5p REST -0.306104092733909 0.370798466662369 -0.407127725825328 0.544173719879236 MirTarget -0.325686334836983 0.0265594403178241 NA NA NA hsa-miR-125a-5p RFXANK -0.306104092733909 0.370798466662369 -0.00329675780096217 0.990342928635687 MirTarget;miRanda;miRNATAP -0.118769591179414 0.0450663979252939 NA NA NA hsa-miR-125a-5p RGS16 -0.306104092733909 0.370798466662369 0.180502028534765 0.783434986053131 miRanda -0.340703093699673 0.0175523070756067 NA NA NA hsa-miR-125a-5p RIN3 -0.306104092733909 0.370798466662369 -0.897729389388278 0.0139827902760425 miRanda;mirMAP -0.231284920046661 0.00380484100373627 NA NA NA hsa-miR-125a-5p RIT1 -0.306104092733909 0.370798466662369 -0.00695563297227775 0.974019849689317 miRanda -0.101682081707256 0.027756205608598 NA NA NA hsa-miR-125a-5p RNF141 -0.306104092733909 0.370798466662369 0.15397192558942 0.524103721845794 miRanda -0.11825604317336 0.0241243737990515 NA NA NA hsa-miR-125a-5p RP1 -0.306104092733909 0.370798466662369 0.864619525959042 0.44943051077714 miRanda -0.889573043777864 0.0003271416821115 NA NA NA hsa-miR-125a-5p RPL35A -0.306104092733909 0.370798466662369 0.261150838113076 0.390938670152961 miRNAWalker2_validate -0.22196573644045 0.000732497842381305 NA NA NA hsa-miR-125a-5p RPLP0P2 -0.306104092733909 0.370798466662369 -0.488765187498007 0.421434089534681 miRanda -0.366978137435856 0.0056150975964694 NA NA NA hsa-miR-125a-5p RPS2 -0.306104092733909 0.370798466662369 0.109359790295221 0.734291754198143 miRNAWalker2_validate -0.258109328194027 0.000196452183093021 NA NA NA hsa-miR-125a-5p RPS6KA1 -0.306104092733909 0.370798466662369 -0.337520803567728 0.248030881360613 MirTarget;PITA;miRanda -0.235414485976983 0.000181428915851691 NA NA NA hsa-miR-125a-5p RRM2 -0.306104092733909 0.370798466662369 0.643936525720886 0.304099528115377 miRanda -0.779290019144789 3.25094003046435e-09 NA NA NA hsa-miR-125a-5p RSPO1 -0.306104092733909 0.370798466662369 0.83845196765616 0.39439053313667 miRanda -0.484203602883878 0.0246902325025045 NA NA NA hsa-miR-125a-5p RTKN2 -0.306104092733909 0.370798466662369 -0.0372690420404025 0.954961299801486 miRanda -0.309653676589159 0.0319284462846563 NA NA NA hsa-miR-125a-5p SATB2 -0.306104092733909 0.370798466662369 0.637715401444317 0.120450245428271 PITA;miRanda -0.195195571845859 0.0299745549572937 NA NA NA hsa-miR-125a-5p SBNO2 -0.306104092733909 0.370798466662369 0.0862007072462374 0.80071137108401 PITA -0.170487240522001 0.0219007989042649 NA NA NA hsa-miR-125a-5p SDC1 -0.306104092733909 0.370798466662369 1.96228608760344 0.00236726882577487 mirMAP -0.70814297804088 3.40585050881109e-07 NA NA NA hsa-miR-125a-5p SEC14L2 -0.306104092733909 0.370798466662369 0.921583819454055 0.052353373474255 MirTarget;miRanda;mirMAP -0.275207458824835 0.00812061181750619 NA NA NA hsa-miR-125a-5p SEMA3B -0.306104092733909 0.370798466662369 0.96873879879664 0.118871875513988 miRanda -0.427213860996021 0.0015911699259744 NA NA NA hsa-miR-125a-5p SEPT9 -0.306104092733909 0.370798466662369 -0.111438654279379 0.711539013452268 miRanda;mirMAP -0.218395387142963 0.000782272485895894 NA NA NA hsa-miR-532-3p SFN -0.736090840140927 0.0634876924080901 3.04330373800433 0.0150178015350522 miRNATAP -0.545493392865506 0.0206351334511309 NA NA NA hsa-miR-125a-5p SFXN2 -0.306104092733909 0.370798466662369 0.122788559287368 0.74656496157464 miRanda -0.287961409179426 0.000447787962636685 NA NA NA hsa-miR-125a-5p SH3BP4 -0.306104092733909 0.370798466662369 0.53827786203237 0.151103596233759 PITA;miRanda;miRNATAP -0.451786524751549 1.04824222254163e-08 NA NA NA hsa-miR-125a-5p SH3TC2 -0.306104092733909 0.370798466662369 2.1404761259292 0.0013993383570451 MirTarget;PITA -0.42078670384183 0.00443988375253718 NA NA NA hsa-miR-125a-5p SIX5 -0.306104092733909 0.370798466662369 0.103099773564087 0.753968166734783 miRanda;mirMAP -0.24868654212649 0.000455618795805966 NA NA NA hsa-miR-130a-3p SKP1 -1.16553771395741 0.000345368434227973 0.160964624098019 0.303028493702543 MirTarget -0.146453231994266 1.68144272683298e-05 NA NA NA hsa-miR-450b-5p SKP1 -0.947307681071554 0.0182365957775615 0.160964624098019 0.303028493702543 miRNATAP -0.114276034872596 3.77222748984042e-05 NA NA NA hsa-miR-26a-5p SKP2 -0.595418372285298 0.0245871761064168 0.10008503332001 0.773083900650187 MirTarget -0.344506697553844 0.000413378763226844 NA NA NA hsa-miR-26b-5p SKP2 -1.21629873619115 0.000852008439136243 0.10008503332001 0.773083900650187 MirTarget -0.254919140013597 0.000216575379458402 NA NA NA hsa-miR-30a-5p SKP2 -0.588553206289925 0.175311638663077 0.10008503332001 0.773083900650187 MirTarget;miRNATAP -0.148389702701357 0.0117318547321496 NA NA NA hsa-miR-30b-5p SKP2 -0.68249444596921 0.0731627218334145 0.10008503332001 0.773083900650187 MirTarget;miRNATAP -0.257135092363058 0.000110020556069977 NA NA NA hsa-miR-30c-5p SKP2 -0.877497703999593 0.00776562825190586 0.10008503332001 0.773083900650187 MirTarget;miRNATAP -0.314765023116271 4.04002936542477e-05 NA NA NA hsa-miR-340-5p SKP2 -0.873554108779771 0.0362049958643107 0.10008503332001 0.773083900650187 MirTarget;miRNATAP -0.192125913499398 0.00159551281850226 25151966 At the same time miR-340 induces the stabilization of p27 by targeting SKP2 the key posttranslational regulator of p27; Accordingly the inhibition of either PUM1 or SKP2 partially recapitulates the miR-340 effect on cell proliferation and apoptosis lung squamous cell cancer hsa-miR-125a-5p SLC11A1 -0.306104092733909 0.370798466662369 -1.2872567074412 0.0537078117709614 miRanda;mirMAP -0.383176793555665 0.00878979023969181 NA NA NA hsa-miR-125a-5p SLC12A7 -0.306104092733909 0.370798466662369 0.0534694842506056 0.859399760095193 mirMAP -0.137057108378235 0.0370871315195466 NA NA NA hsa-miR-125a-5p SLC1A5 -0.306104092733909 0.370798466662369 1.01103613200908 0.0271843144378623 miRNAWalker2_validate;miRanda -0.660991021902815 3.19587983728638e-12 NA NA NA hsa-miR-125a-5p SLC25A10 -0.306104092733909 0.370798466662369 1.0994957245885 0.00786417034577237 mirMAP -0.274998797502136 0.00240714050616243 NA NA NA hsa-miR-125a-5p SLC25A15 -0.306104092733909 0.370798466662369 0.293034703625372 0.324047623392136 MirTarget;PITA;miRanda -0.339108468314388 6.10827487937179e-08 NA NA NA hsa-miR-125a-5p SLC26A6 -0.306104092733909 0.370798466662369 0.369267914745508 0.393976783386216 MirTarget;PITA;miRanda;miRNATAP -0.361951429143942 0.000105538760046653 NA NA NA hsa-miR-125a-5p SLC35C1 -0.306104092733909 0.370798466662369 0.722829037817421 0.0114458952492091 miRanda -0.253701825433232 3.91164530664744e-05 NA NA NA hsa-miR-125a-5p SLC39A8 -0.306104092733909 0.370798466662369 0.16894073079798 0.695809161998798 miRanda -0.438273549594339 1.93545624386612e-06 NA NA NA hsa-miR-125a-5p SLC44A2 -0.306104092733909 0.370798466662369 -0.13987505120526 0.645845302201901 miRanda -0.216410670558903 0.000992344497439287 NA NA NA hsa-miR-125a-5p SLC45A3 -0.306104092733909 0.370798466662369 0.992298446394069 0.138144528333836 MirTarget;miRanda -0.629041959440515 1.24193832167092e-05 NA NA NA hsa-miR-125a-5p SLFN11 -0.306104092733909 0.370798466662369 -0.729948125832699 0.115353046057502 miRNAWalker2_validate -0.267342112861183 0.00830389125513832 NA NA NA hsa-let-7a-3p SMAD2 -0.95056529442537 0.00672174661147133 -0.180089737520865 0.268245606486482 mirMAP -0.171423380558895 1.58806489211087e-07 NA NA NA hsa-miR-106b-5p SMAD2 -0.814181559290382 0.00942928404699138 -0.180089737520865 0.268245606486482 mirMAP -0.129925428359931 0.000545712901287238 NA NA NA hsa-miR-16-2-3p SMAD2 -1.02821208937232 0.00734958396812714 -0.180089737520865 0.268245606486482 mirMAP -0.148076077917134 7.49329345081865e-07 NA NA NA hsa-miR-19a-3p SMAD2 -1.39804789764109 0.00390589133951138 -0.180089737520865 0.268245606486482 mirMAP -0.120510682174934 2.73707704209844e-07 NA NA NA hsa-miR-19b-3p SMAD2 -1.3861807379685 0.00102515671649667 -0.180089737520865 0.268245606486482 mirMAP -0.15682146627541 3.75672091920055e-09 NA NA NA hsa-miR-26b-5p SMAD2 -1.21629873619115 0.000852008439136243 -0.180089737520865 0.268245606486482 mirMAP -0.13304025240718 2.63733308878132e-05 NA NA NA hsa-miR-30b-5p SMAD2 -0.68249444596921 0.0731627218334145 -0.180089737520865 0.268245606486482 mirMAP -0.13481183802648 9.97268944042074e-06 NA NA NA hsa-miR-30c-5p SMAD2 -0.877497703999593 0.00776562825190586 -0.180089737520865 0.268245606486482 mirMAP -0.117306845251205 0.00101831434480386 NA NA NA hsa-miR-374b-5p SMAD2 -0.936361879691007 0.00140373477346958 -0.180089737520865 0.268245606486482 MirTarget -0.188224005556212 1.97775565171802e-06 NA NA NA hsa-let-7g-3p SMAD3 -0.841943598032208 0.0192258112225686 -0.0534330497638233 0.898687186989926 mirMAP -0.259850009257065 0.00247186407978444 NA NA NA hsa-miR-132-3p SMAD3 -0.188684269862105 0.638562246194811 -0.0534330497638233 0.898687186989926 mirMAP -0.368782899844193 1.06831574331197e-06 NA NA NA hsa-miR-15a-5p SMAD3 -0.736232967654847 0.0107385113851643 -0.0534330497638233 0.898687186989926 MirTarget -0.256668174150821 0.0180627137224929 NA NA NA hsa-miR-188-5p SMAD3 -0.720117619850595 0.196198812847651 -0.0534330497638233 0.898687186989926 PITA -0.196480426885753 0.000348920240829844 NA NA NA hsa-miR-212-3p SMAD3 -0.367966702435511 0.450158366088537 -0.0534330497638233 0.898687186989926 mirMAP -0.245158850948897 9.20242428255486e-05 NA NA NA hsa-miR-29b-2-5p SMAD3 -0.615199776501198 0.100092846442163 -0.0534330497638233 0.898687186989926 mirMAP -0.322000132767508 8.63372534067604e-05 NA NA NA hsa-miR-330-3p SMAD3 0.226896608253308 0.63792060187889 -0.0534330497638233 0.898687186989926 mirMAP -0.169975685971777 0.00803324014261503 NA NA NA hsa-miR-335-5p SMAD3 -0.913728460165869 0.0568330413961764 -0.0534330497638233 0.898687186989926 miRNAWalker2_validate -0.135629773709254 0.0351417581663178 NA NA NA hsa-miR-485-3p SMAD3 -1.07524599303664 0.0567048241974248 -0.0534330497638233 0.898687186989926 MirTarget -0.150919171912439 0.00546671588638413 NA NA NA hsa-miR-495-3p SMAD3 -0.819711095165138 0.0930619218141869 -0.0534330497638233 0.898687186989926 mirMAP -0.169819699712115 0.00710201092454279 NA NA NA hsa-miR-501-5p SMAD3 -0.634663345778922 0.169048284923239 -0.0534330497638233 0.898687186989926 mirMAP -0.27470777996011 3.29821438350009e-05 NA NA NA hsa-miR-543 SMAD3 -1.03495265003894 0.0713462149984802 -0.0534330497638233 0.898687186989926 mirMAP -0.170285610077232 0.00151848370230442 NA NA NA hsa-miR-671-5p SMAD3 -0.162477213196106 0.728998069332297 -0.0534330497638233 0.898687186989926 MirTarget -0.2316764375527 0.000419178228372682 NA NA NA hsa-miR-7-1-3p SMAD3 -0.729687864305395 0.0834004484481893 -0.0534330497638233 0.898687186989926 mirMAP -0.26029364646289 0.000346072624966569 NA NA NA hsa-miR-769-5p SMAD3 -0.221361941699318 0.444319261990614 -0.0534330497638233 0.898687186989926 miRNATAP -0.350974731160708 0.00120828366555818 NA NA NA hsa-let-7a-3p SMAD4 -0.95056529442537 0.00672174661147133 -0.50077914407411 0.122400796221135 mirMAP -0.205947597363243 0.00244662508136492 NA NA NA hsa-miR-106b-5p SMAD4 -0.814181559290382 0.00942928404699138 -0.50077914407411 0.122400796221135 mirMAP;miRNATAP -0.249876913849852 0.00106003889481042 NA NA NA hsa-miR-146a-5p SMAD4 -1.11593345585213 0.0577697674405714 -0.50077914407411 0.122400796221135 miRNAWalker2_validate;miRTarBase -0.117076563463845 0.0036223789229017 21982769;27438138;22020746 The results indicated that miR-146a regulated the sensitivity of HCC cells to the cytotoxic effects of IFN-α through SMAD4 suggesting that this miRNA could be suitable for prediction of the clinical response and potential therapeutic target in HCC patients on IFN-based therapy;SMAD4 was identified as a miR-146a target and was downregulated in BARF1-expressing cells whereas SMAD4 expression was restored by anti-miR-146a; Knockdown of BARF1 in YCCEL1 cells upregulated SMAD4 and this effect was reversed by miR-146a overexpression; In stomach cancer tissues miR-146a was expressed at higher levels and more frequent NFκB nuclear positivity immunohistochemically but not of SMAD4 nuclear loss was found in the EBV-positive group compared with the EBV-negative group; In conclusion EBV-encoded BARF1 promotes cell proliferation in stomach cancer by upregulating NFκB and miR-146a and downregulating SMAD4 thereby contributing to EBV-induced stomach cancer progression;Increased miR 146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis; Using target prediction algorithms luciferase reporter assay and Western blot assay SMAD family member 4 SMAD4 was identified as a target gene of miR-146a in gastric cancer; Moreover an inverse correlation was observed between the expression of SMAD4 mRNA and miR-146a in gastric cancer tissues R=-0.731 P=0.039 Pearson's correlation; Taken together our results provide important evidence that miR-146a can directly target SMAD4 and suggest that miR-146a may play a role in the development of gastric cancer by modulating cell proliferation and apoptosis drug resistance;progression; liver cancer;gastric cancer;gastric cancer hsa-miR-146b-5p SMAD4 -1.18658780090466 0.0132247381969501 -0.50077914407411 0.122400796221135 PITA;miRanda;miRNATAP -0.132614931447462 0.00740550445122568 21874046;26883911 MicroRNA miR 146b 5p regulates signal transduction of TGF β by repressing SMAD4 in thyroid cancer; A computational search revealed that miR-146b-5p putatively binds to the 3' untranslated region UTR of SMAD4 an important member of the transforming growth factor β TGF-β signaling pathway; Luciferase reporter assay confirmed the direct binding of miR-146b-5p on the SMAD4 3'UTR; Specific inhibition of miR-146b-5p with a locked nucleic acid-modified anti-miR-146b oligonucleotide significantly increased SMAD4 levels in the human papillary carcinoma cell lines TPC-1 and BCPAP; The overexpression of miR-146b-5p in normal rat follicular PCCL3 cells decreased SMAD4 levels and disrupted TGF-β signal transduction;The overexpression of SMAD4 in BCPAP cells a validated target of miR-146b-5p and key protein in the TGF-β signaling pathway inhibited migration similarly to the effects observed with the antagomiR 146b-5p ; thyroid cancer;thyroid cancer hsa-miR-155-5p SMAD4 -1.43184489211345 0.00780837893756083 -0.50077914407411 0.122400796221135 miRNAWalker2_validate -0.123291415533456 0.00493868080113682 27626488 Here we demonstrated that TGF-β1 elevated the expression of miR-155 in colorectal cancer cells through SMAD3 and SMAD4 colorectal cancer hsa-miR-17-5p SMAD4 -0.667512721923102 0.0423050196597589 -0.50077914407411 0.122400796221135 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.29572089777507 4.3172519111787e-05 NA NA NA hsa-miR-182-5p SMAD4 0.193824666419893 0.730295924168823 -0.50077914407411 0.122400796221135 miRNAWalker2_validate -0.130870992983984 0.00195562568122698 23226455 We also identified Smad4 and RECK as potential target genes of miR-182-5p using several algorithms; In conclusion our data suggests that miR-182-5p plays an important role as an oncogene by knocking down RECK and Smad4 resulting in activation of the Wnt-beta-catenin signaling pathway in bladder cancer bladder cancer hsa-miR-18a-5p SMAD4 -1.17872230313757 0.0043629711019433 -0.50077914407411 0.122400796221135 miRNAWalker2_validate -0.242891625583503 1.73615365761236e-05 NA NA NA hsa-miR-199b-5p SMAD4 0.438479083653495 0.438925410515967 -0.50077914407411 0.122400796221135 miRanda -0.125100021196607 0.00286182945297599 NA NA NA hsa-miR-19a-3p SMAD4 -1.39804789764109 0.00390589133951138 -0.50077914407411 0.122400796221135 miRNAWalker2_validate;miRTarBase;mirMAP;miRNATAP -0.144250912304382 0.00304667886904753 NA NA NA hsa-miR-19b-3p SMAD4 -1.3861807379685 0.00102515671649667 -0.50077914407411 0.122400796221135 miRNAWalker2_validate;mirMAP;miRNATAP -0.182001555943195 0.00109137324336703 NA NA NA hsa-miR-200a-3p SMAD4 1.68929243108599 0.00872253595562164 -0.50077914407411 0.122400796221135 mirMAP -0.114706692168343 0.0016575673487447 NA NA NA hsa-miR-200b-3p SMAD4 1.84496256556404 0.00297111610556856 -0.50077914407411 0.122400796221135 mirMAP -0.152526486612736 4.51586016043491e-05 NA NA NA hsa-miR-203a-3p SMAD4 1.97571040954712 0.0326593804470764 -0.50077914407411 0.122400796221135 miRTarBase -0.194692615753514 1.10242245065365e-16 NA NA NA hsa-miR-20a-5p SMAD4 -0.39483820331792 0.269587643143535 -0.50077914407411 0.122400796221135 miRNAWalker2_validate;mirMAP;miRNATAP -0.29157581641953 1.07573355458111e-05 27286257 MicroRNA 20a 5p promotes colorectal cancer invasion and metastasis by downregulating Smad4; miR-20a-5p negatively regulated Smad4 by directly targeting its 3'UTR in human colorectal cancer cells; miR-20a-5p not only promoted CRC cells aggression capacity in vitro and liver metastasis in vivo but also promoted the epithelial-to-mesenchymal transition process by downregulating Smad4 expression; Luciferase reporter assay and transfection technique were used to validate the correlation between miR-20a-5p and Smad4 in CRC; Wound healing transwell and tumorigenesis assays were used to explore the function of miR-20a-5p and Smad4 in CRC progression in vitro and in vivo; miR-20a-5p as an onco-miRNA promoted the invasion and metastasis ability by suppressing Smad4 expression in CRC cells and high miR-20a-5p predicted poor prognosis for CRC patients providing a novel and promising therapeutic target in human colorectal cancer metastasis;progression;tumorigenesis;worse prognosis colorectal cancer hsa-miR-21-3p SMAD4 -0.439466085308428 0.449347936730943 -0.50077914407411 0.122400796221135 mirMAP -0.185394898621729 4.01015755574723e-06 NA NA NA hsa-miR-214-5p SMAD4 -0.511727798007622 0.242368882647901 -0.50077914407411 0.122400796221135 MirTarget -0.122092234617239 0.025948387568966 NA NA NA hsa-miR-224-3p SMAD4 -0.911915347414965 0.109316868416341 -0.50077914407411 0.122400796221135 mirMAP -0.136991444013132 0.000996118795598193 24817781;24152489;26187928;23913306;25804630;26307684 Increased miR-224 diminished Cdc42 and SMAD4 expressions at both the protein and mRNA levels and inhibited the formation of actin filaments;In addition the regulation of SMAD4 by miR-224 was evaluated by qRT-PCR Western blotting and luciferase reporter assays; Furthermore the over-expression of miR-224 in CRC cell lines decreased SMAD4 expression at the translational level and decreased SMAD4-driven luciferase-reporter activity;Increased miR-224 expression promotes cell migration invasion and proliferation by directly targeting the tumor suppressors TNFα-induced protein 1 TNFAIP1 and SMAD4; Up-regulated miR-224 thus facilitates tumor progression by shifting the equilibrium of the partially antagonist functions of SMAD4 and TNFAIP1 toward enhanced invasion and growth in NSCLC;Our in vitro study demonstrated that miR-224 played an oncogenic role in hepatoma cell migration and tumor formation through silencing its target gene Smad4; A noncanonical pathway links autophagy miR-224 Smad4 and HBV-associated HCC;We identified SMAD4 as a miR-224 target and observed negative correlation Spearman Rs=-0.44 p<0.0001 between SMAD4 and miR-224 expression in clinical samples; In the TCGA set combined analysis of miR-224 with SMAD4 expression enhanced correlation with survival HR 4.12 95% CI 1.1 to 15.41 p=0.0175; MiR-224 promotes CRC metastasis at least in part through the regulation of SMAD4;We further demonstrated that miR-224 functions as an oncogene in NSCLC by directly targeting TNFAIP1 and SMAD4 ;;cell migration;progression;cell migration;poor survival;metastasis; colorectal cancer;colorectal cancer;lung squamous cell cancer;liver cancer;colorectal cancer;lung cancer hsa-miR-224-5p SMAD4 -0.272705922198226 0.694358594064224 -0.50077914407411 0.122400796221135 miRNAWalker2_validate;miRTarBase;MirTarget -0.145685232762603 1.55569967242327e-05 24817781;24152489;26187928;23913306;25804630;26307684 Increased miR-224 diminished Cdc42 and SMAD4 expressions at both the protein and mRNA levels and inhibited the formation of actin filaments;In addition the regulation of SMAD4 by miR-224 was evaluated by qRT-PCR Western blotting and luciferase reporter assays; Furthermore the over-expression of miR-224 in CRC cell lines decreased SMAD4 expression at the translational level and decreased SMAD4-driven luciferase-reporter activity;Increased miR-224 expression promotes cell migration invasion and proliferation by directly targeting the tumor suppressors TNFα-induced protein 1 TNFAIP1 and SMAD4; Up-regulated miR-224 thus facilitates tumor progression by shifting the equilibrium of the partially antagonist functions of SMAD4 and TNFAIP1 toward enhanced invasion and growth in NSCLC;Our in vitro study demonstrated that miR-224 played an oncogenic role in hepatoma cell migration and tumor formation through silencing its target gene Smad4; A noncanonical pathway links autophagy miR-224 Smad4 and HBV-associated HCC;We identified SMAD4 as a miR-224 target and observed negative correlation Spearman Rs=-0.44 p<0.0001 between SMAD4 and miR-224 expression in clinical samples; In the TCGA set combined analysis of miR-224 with SMAD4 expression enhanced correlation with survival HR 4.12 95% CI 1.1 to 15.41 p=0.0175; MiR-224 promotes CRC metastasis at least in part through the regulation of SMAD4;We further demonstrated that miR-224 functions as an oncogene in NSCLC by directly targeting TNFAIP1 and SMAD4 ;;cell migration;progression;cell migration;poor survival;metastasis; colorectal cancer;colorectal cancer;lung squamous cell cancer;liver cancer;colorectal cancer;lung cancer hsa-miR-2355-5p SMAD4 -1.08517653035517 0.00642258691220897 -0.50077914407411 0.122400796221135 MirTarget -0.206998343364797 0.000486259398221052 NA NA NA hsa-miR-26b-5p SMAD4 -1.21629873619115 0.000852008439136243 -0.50077914407411 0.122400796221135 MirTarget;miRNATAP -0.132151390652733 0.0432678509783993 24890815 Overexpression of miR-26b also repressed Smad4 expression whereas its inhibition elevated Smad4 expression; In HCC cell lines miR-26b targeted the 3'UTR of USP9X which in turn affects EMT through Smad4 and the TGF-β signaling pathway liver cancer hsa-miR-27a-3p SMAD4 -0.608119079188439 0.0980109363388155 -0.50077914407411 0.122400796221135 MirTarget -0.330016440548527 2.1163040622072e-07 NA NA NA hsa-miR-27a-5p SMAD4 0.0468030992459996 0.938853824507271 -0.50077914407411 0.122400796221135 miRNATAP -0.107945908542803 0.00564849054619648 NA NA NA hsa-miR-28-3p SMAD4 -0.678103452503894 0.0479621534589748 -0.50077914407411 0.122400796221135 mirMAP -0.225041233086025 0.00126674222798259 NA NA NA hsa-miR-28-5p SMAD4 -0.527293772469832 0.0304183293001878 -0.50077914407411 0.122400796221135 miRanda;miRNATAP -0.266874328990303 0.00812647766271969 NA NA NA hsa-miR-335-3p SMAD4 -0.496550554602651 0.223248314670008 -0.50077914407411 0.122400796221135 mirMAP -0.121388410687311 0.039751889485005 NA NA NA hsa-miR-34a-5p SMAD4 -0.243748387753732 0.416958179815378 -0.50077914407411 0.122400796221135 miRNATAP -0.300354605111149 0.000181361250198161 22750848 Mechanistically in addition to its direct regulation of platelet-derived growth factor receptor-alpha PDGFRA promoter enrichment analysis of context likelihood of relatedness-inferred mRNA nodes established miR-34a as a novel regulator of a SMAD4 transcriptional network; Specifically in glioblastoma within the context of the global network promoter enrichment analysis of network edges uncovered a novel regulation of TGF-β signaling via a Smad4 transcriptomic network by miR-34a glioblastoma hsa-miR-34c-5p SMAD4 -0.0182044536033139 0.971130549817106 -0.50077914407411 0.122400796221135 miRanda;miRNATAP -0.166052330014586 0.000446284845675396 NA NA NA hsa-miR-425-5p SMAD4 -0.823997055533763 0.0503055363537137 -0.50077914407411 0.122400796221135 mirMAP -0.266859071623979 1.50654373050829e-06 NA NA NA hsa-miR-429 SMAD4 1.86385884044684 0.00726080911989418 -0.50077914407411 0.122400796221135 PITA;miRanda;miRNATAP -0.122352301270891 0.00027489154800068 NA NA NA hsa-miR-450b-5p SMAD4 -0.947307681071554 0.0182365957775615 -0.50077914407411 0.122400796221135 mirMAP -0.165449873025985 0.00533059657823932 NA NA NA hsa-miR-508-3p SMAD4 0.0507610646687757 0.943836540300711 -0.50077914407411 0.122400796221135 PITA;miRNATAP -0.16786227847215 1.99834916882605e-07 NA NA NA hsa-miR-92a-3p SMAD4 -0.417284456385998 0.14690346065742 -0.50077914407411 0.122400796221135 miRNAWalker2_validate;mirMAP -0.270021301173749 0.00134684146183073 NA NA NA hsa-miR-93-5p SMAD4 -0.468459476414832 0.131463449813313 -0.50077914407411 0.122400796221135 miRNAWalker2_validate;mirMAP;miRNATAP -0.315979911245671 4.01744806900024e-05 NA NA NA hsa-miR-125a-5p SMAD6 -0.306104092733909 0.370798466662369 0.880435726391675 0.0434672596291641 miRanda -0.280731087789955 0.00319580528212615 NA NA NA hsa-miR-125a-5p SMARCD2 -0.306104092733909 0.370798466662369 -0.0349865124245383 0.87806452757513 miRanda -0.20366107776913 2.7307696049529e-05 NA NA NA hsa-miR-21-5p SMC1A 0.313529032828654 0.492407646988864 -0.13744467788523 0.587282024575698 miRNAWalker2_validate;mirMAP -0.106164488240842 0.00907995790967889 NA NA NA hsa-miR-429 SMC1B 1.86385884044684 0.00726080911989418 -0.0170939184463132 0.985635116004665 miRanda -0.322680398411479 0.00111347801415015 NA NA NA hsa-miR-92a-3p SMC3 -0.417284456385998 0.14690346065742 -0.0299353378786282 0.889932993684923 miRNAWalker2_validate -0.132084277209466 0.0183829718716604 NA NA NA hsa-miR-125a-5p SNRPB -0.306104092733909 0.370798466662369 0.14882508446794 0.591425895905806 PITA;miRanda -0.164717751408831 0.00611048471438572 NA NA NA hsa-miR-125a-5p SNX33 -0.306104092733909 0.370798466662369 0.235614402858057 0.357863363425855 mirMAP -0.283729380366473 1.48825115752459e-07 NA NA NA hsa-miR-125a-5p SOD2 -0.306104092733909 0.370798466662369 -0.998484542390253 0.0252075004530608 miRanda -0.231020480458202 0.018379961014533 NA NA NA hsa-miR-125a-5p SP1 -0.306104092733909 0.370798466662369 0.0644885533042308 0.775964210774396 miRNAWalker2_validate -0.144127111276695 0.00316340315016484 NA NA NA hsa-miR-125a-5p SP140L -0.306104092733909 0.370798466662369 -0.295296122397201 0.496340277875158 miRanda -0.315804402540507 0.00077927884658946 NA NA NA hsa-miR-125a-5p SP5 -0.306104092733909 0.370798466662369 2.22257948968328 0.00302425828121727 miRanda -0.487859900434019 0.00311542468045267 NA NA NA hsa-miR-125a-5p SPACA3 -0.306104092733909 0.370798466662369 1.11029221880089 0.343115043590819 miRanda -0.518168129670309 0.0436889589849759 NA NA NA hsa-miR-125a-5p SPNS2 -0.306104092733909 0.370798466662369 -0.0546403723213222 0.918677267514045 mirMAP -0.429216965740768 0.000202637438963129 NA NA NA hsa-miR-125a-5p SPRR3 -0.306104092733909 0.370798466662369 4.53839043884284 0.0146028551280322 miRanda -0.999236865489437 0.0146816829667724 NA NA NA hsa-miR-125a-5p SRGAP1 -0.306104092733909 0.370798466662369 0.0831164703231382 0.786626740459738 miRanda -0.241771784637213 0.000252550048385819 NA NA NA hsa-miR-125a-5p SSR2 -0.306104092733909 0.370798466662369 0.265952358757838 0.256611394666306 PITA;miRanda -0.22787797719557 4.74666152153657e-06 NA NA NA hsa-miR-141-3p STAG1 1.13131842772144 0.0966666388085424 -0.174230597945571 0.595514773049055 TargetScan -0.108424331333807 0.00195398298851723 NA NA NA hsa-miR-182-5p STAG1 0.193824666419893 0.730295924168823 -0.174230597945571 0.595514773049055 miRNATAP -0.109902877280728 0.0103083518832098 NA NA NA hsa-miR-26b-5p STAG1 -1.21629873619115 0.000852008439136243 -0.174230597945571 0.595514773049055 miRNAWalker2_validate -0.239071930200826 0.000243973729835543 NA NA NA hsa-miR-27b-3p STAG1 -0.438722013067046 0.128009126450996 -0.174230597945571 0.595514773049055 MirTarget;miRNATAP -0.183722370051299 0.0316364316568682 NA NA NA hsa-miR-30b-5p STAG1 -0.68249444596921 0.0731627218334145 -0.174230597945571 0.595514773049055 MirTarget -0.282407150000243 5.97504289393831e-06 NA NA NA hsa-miR-30c-5p STAG1 -0.877497703999593 0.00776562825190586 -0.174230597945571 0.595514773049055 MirTarget -0.196496056219487 0.00746822864623409 NA NA NA hsa-miR-429 STAG1 1.86385884044684 0.00726080911989418 -0.174230597945571 0.595514773049055 miRanda -0.110322376403282 0.00120913371164706 NA NA NA hsa-miR-590-3p STAG1 -0.921957466414335 0.0345620969748757 -0.174230597945571 0.595514773049055 miRanda;mirMAP -0.172921392677249 0.0016442537352881 NA NA NA hsa-miR-92a-3p STAG1 -0.417284456385998 0.14690346065742 -0.174230597945571 0.595514773049055 miRNAWalker2_validate -0.198458916595679 0.0204454883703941 NA NA NA hsa-miR-96-5p STAG1 -0.14300109523641 0.834020197937914 -0.174230597945571 0.595514773049055 TargetScan;miRNATAP -0.14507814938774 2.88302022261389e-05 NA NA NA hsa-miR-16-2-3p STAG2 -1.02821208937232 0.00734958396812714 0.0187106955339909 0.931290219376338 MirTarget -0.118411235819995 0.00398163585604393 NA NA NA hsa-miR-21-5p STAG2 0.313529032828654 0.492407646988864 0.0187106955339909 0.931290219376338 miRNAWalker2_validate;MirTarget;miRNATAP -0.116647867231889 0.000729856371091489 NA NA NA hsa-miR-34a-5p STAG2 -0.243748387753732 0.416958179815378 0.0187106955339909 0.931290219376338 miRNAWalker2_validate;miRNATAP -0.114639005754144 0.0333851401627693 NA NA NA hsa-miR-125a-5p SYTL4 -0.306104092733909 0.370798466662369 0.399221213214619 0.37602527577027 miRanda -0.561142297720035 2.98673067154971e-09 NA NA NA hsa-miR-125a-5p TAF12 -0.306104092733909 0.370798466662369 -0.0169257842146697 0.928489303618578 miRanda -0.131585578387138 0.00110587673460706 NA NA NA hsa-miR-125a-5p TAP2 -0.306104092733909 0.370798466662369 -0.266498298912073 0.422899114402493 miRanda -0.161410152490406 0.0259932801723976 NA NA NA hsa-miR-125a-5p TBC1D1 -0.306104092733909 0.370798466662369 -0.2501456378562 0.293275384165505 miRNAWalker2_validate;MirTarget;PITA;miRanda -0.172459780484081 0.000761958225068384 NA NA NA hsa-miR-125a-5p TBC1D7 -0.306104092733909 0.370798466662369 0.209461043817442 0.459689032289371 miRanda -0.237460493278852 9.34171945068981e-05 NA NA NA hsa-miR-125a-5p TBC1D8B -0.306104092733909 0.370798466662369 0.632793879196443 0.0689019047760613 miRanda -0.184160938667244 0.015466255977591 NA NA NA hsa-miR-125a-5p TBX4 -0.306104092733909 0.370798466662369 2.2798364878951 0.0137703180423861 PITA;miRanda -0.544234404952302 0.00750028965665567 NA NA NA hsa-miR-125a-5p TCAM1P -0.306104092733909 0.370798466662369 0.0436255420116458 0.965999796707341 miRanda -0.510062098807217 0.0226872166850707 NA NA NA hsa-miR-125a-5p TCF19 -0.306104092733909 0.370798466662369 0.304774481318197 0.34811428930184 miRanda -0.296342937983977 2.04062425013283e-05 NA NA NA hsa-miR-125a-5p TCF7 -0.306104092733909 0.370798466662369 -0.84367713596191 0.124089127072374 miRanda -0.503759159131758 1.99488638698137e-05 NA NA NA hsa-miR-101-5p TFDP2 -0.699849074885007 0.0367852250865455 0.249553591626884 0.349038347027623 mirMAP -0.150336261036955 0.0105379085441754 NA NA NA hsa-miR-125a-5p TFDP2 -0.306104092733909 0.370798466662369 0.249553591626884 0.349038347027623 mirMAP -0.141351048118366 0.0145996863141696 NA NA NA hsa-miR-126-5p TFDP2 -1.40161784967373 0.000199780495822923 0.249553591626884 0.349038347027623 mirMAP -0.216943221060136 1.75019327492228e-05 NA NA NA hsa-miR-1271-5p TFDP2 -1.24586342526042 0.00150921978299137 0.249553591626884 0.349038347027623 MirTarget;mirMAP -0.104255443457829 0.0356006208945228 NA NA NA hsa-miR-1301-3p TFDP2 -0.999688653524287 0.0314946527837359 0.249553591626884 0.349038347027623 MirTarget -0.223084928208247 3.8326242742945e-08 NA NA NA hsa-miR-132-3p TFDP2 -0.188684269862105 0.638562246194811 0.249553591626884 0.349038347027623 mirMAP -0.134205032064692 0.00607391457548685 NA NA NA hsa-miR-148b-3p TFDP2 -0.0990745204340264 0.77230139028333 0.249553591626884 0.349038347027623 MirTarget -0.274833168035948 1.14388501947271e-06 NA NA NA hsa-miR-153-3p TFDP2 -0.0119363528689118 0.988468032725161 0.249553591626884 0.349038347027623 MirTarget -0.111534987277699 1.24418856960377e-06 NA NA NA hsa-miR-154-3p TFDP2 -0.636575675304019 0.234544622583329 0.249553591626884 0.349038347027623 TargetScan -0.13166268832797 0.00026393137762152 NA NA NA hsa-miR-15a-5p TFDP2 -0.736232967654847 0.0107385113851643 0.249553591626884 0.349038347027623 MirTarget -0.287502073450706 2.0685381114623e-05 NA NA NA hsa-miR-16-5p TFDP2 -1.02296420363147 0.000327333184982762 0.249553591626884 0.349038347027623 MirTarget;mirMAP -0.192637155726706 0.00514170497760009 NA NA NA hsa-miR-186-5p TFDP2 -0.76553299921128 0.00203425234898652 0.249553591626884 0.349038347027623 MirTarget;mirMAP -0.29780883929066 0.000180723292166209 NA NA NA hsa-miR-19a-3p TFDP2 -1.39804789764109 0.00390589133951138 0.249553591626884 0.349038347027623 MirTarget -0.10821239952103 0.00670888870870034 NA NA NA hsa-miR-299-3p TFDP2 -1.19935146138053 0.0335319213117306 0.249553591626884 0.349038347027623 MirTarget -0.102235892818096 0.00337908973491018 NA NA NA hsa-miR-29b-3p TFDP2 -0.392267406583841 0.343581862655996 0.249553591626884 0.349038347027623 mirMAP -0.120771066912766 0.0108677709967886 NA NA NA hsa-miR-32-5p TFDP2 -1.1697502932723 0.00457026320106483 0.249553591626884 0.349038347027623 MirTarget;mirMAP;miRNATAP -0.109491628779474 0.0204149107291517 NA NA NA hsa-miR-320a TFDP2 -0.528102551253342 0.108863315406874 0.249553591626884 0.349038347027623 mirMAP -0.170003988373933 0.00452727440109161 NA NA NA hsa-miR-335-5p TFDP2 -0.913728460165869 0.0568330413961764 0.249553591626884 0.349038347027623 miRNATAP -0.110424499897552 0.00650010311606074 NA NA NA hsa-miR-340-5p TFDP2 -0.873554108779771 0.0362049958643107 0.249553591626884 0.349038347027623 mirMAP -0.176944700896491 0.000134200891009569 NA NA NA hsa-miR-342-3p TFDP2 -1.50859606438677 0.000361128404069141 0.249553591626884 0.349038347027623 miRNATAP -0.167388428436068 0.000213317176225831 NA NA NA hsa-miR-3607-3p TFDP2 -0.0996014475610343 0.818274259996261 0.249553591626884 0.349038347027623 MirTarget -0.115480474131061 0.0107917665225094 NA NA NA hsa-miR-362-3p TFDP2 -1.20829972287608 0.012574092123476 0.249553591626884 0.349038347027623 mirMAP -0.132357074958325 0.000993469202363647 NA NA NA hsa-miR-376a-5p TFDP2 -1.11394176764617 0.0539029021682109 0.249553591626884 0.349038347027623 mirMAP -0.131104010929639 8.19688108252423e-05 NA NA NA hsa-miR-421 TFDP2 -0.177803877528689 0.691941942432956 0.249553591626884 0.349038347027623 mirMAP -0.159397767124444 0.000262632867273612 NA NA NA hsa-miR-495-3p TFDP2 -0.819711095165138 0.0930619218141869 0.249553591626884 0.349038347027623 mirMAP -0.176583124342435 6.70627342964575e-06 NA NA NA hsa-miR-501-3p TFDP2 -1.02561651155797 0.004055228716503 0.249553591626884 0.349038347027623 MirTarget;TargetScan;miRNATAP -0.161932226447457 0.00300914379160547 NA NA NA hsa-miR-502-3p TFDP2 -0.727559828010508 0.036178842243285 0.249553591626884 0.349038347027623 MirTarget;miRNATAP -0.117404718184491 0.0387647852732108 NA NA NA hsa-miR-590-3p TFDP2 -0.921957466414335 0.0345620969748757 0.249553591626884 0.349038347027623 mirMAP -0.126705670920665 0.00453054720609433 NA NA NA hsa-miR-654-3p TFDP2 -0.667149412999201 0.153586562453175 0.249553591626884 0.349038347027623 mirMAP -0.107334339029347 0.010233179985848 NA NA NA hsa-miR-660-5p TFDP2 -0.196889121709126 0.556115805668951 0.249553591626884 0.349038347027623 mirMAP -0.136783373239215 0.0211502441491295 NA NA NA hsa-miR-7-1-3p TFDP2 -0.729687864305395 0.0834004484481893 0.249553591626884 0.349038347027623 mirMAP -0.117434043621222 0.0114546636122891 NA NA NA hsa-miR-92b-3p TFDP2 0.514365666378666 0.186565269716391 0.249553591626884 0.349038347027623 MirTarget;miRNATAP -0.136210800523723 0.00689668145408929 NA NA NA hsa-miR-125a-5p TFRC -0.306104092733909 0.370798466662369 0.39713844261308 0.304980606540541 miRNAWalker2_validate -0.421558182749168 2.85268400497524e-07 NA NA NA hsa-miR-139-5p TGFB1 -1.63574949154462 0.00653778531863944 -0.532251919643871 0.15977606081224 miRanda -0.104885468590435 0.0224414552556181 NA NA NA hsa-miR-654-5p TGFB1 -0.424188362778671 0.457855106854761 -0.532251919643871 0.15977606081224 miRNATAP -0.100856674685881 0.0398023039531715 NA NA NA hsa-miR-744-5p TGFB1 -0.595778447321061 0.172283646202662 -0.532251919643871 0.15977606081224 miRNAWalker2_validate;miRNATAP -0.22856546712523 0.000320188712701268 NA NA NA hsa-miR-107 TGFB2 0.0358151350299583 0.899122490641298 -0.527193822918201 0.438685064432285 miRanda -0.41112947541078 0.024221885347425 NA NA NA hsa-miR-126-5p TGFB2 -1.40161784967373 0.000199780495822923 -0.527193822918201 0.438685064432285 mirMAP -0.315405557029416 0.0169740320988103 NA NA NA hsa-miR-136-3p TGFB2 -0.555024872056941 0.260740721387986 -0.527193822918201 0.438685064432285 MirTarget -0.206244654340241 0.0434069628237027 NA NA NA hsa-miR-148b-3p TGFB2 -0.0990745204340264 0.77230139028333 -0.527193822918201 0.438685064432285 MirTarget -0.903672865541258 1.92932341047142e-10 NA NA NA hsa-miR-186-5p TGFB2 -0.76553299921128 0.00203425234898652 -0.527193822918201 0.438685064432285 mirMAP -0.576573029225011 0.00516097754340767 NA NA NA hsa-miR-200a-3p TGFB2 1.68929243108599 0.00872253595562164 -0.527193822918201 0.438685064432285 MirTarget;miRNATAP -0.164662914296083 0.0330671232760219 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-29b-3p TGFB2 -0.392267406583841 0.343581862655996 -0.527193822918201 0.438685064432285 miRTarBase;MirTarget;miRNATAP -0.524416648220409 1.19572789616101e-05 NA NA NA hsa-miR-29c-3p TGFB2 -0.133603914094895 0.743610228811317 -0.527193822918201 0.438685064432285 MirTarget;miRNATAP -0.437680009011081 0.000361145649300973 NA NA NA hsa-miR-301a-3p TGFB2 -0.756666069407079 0.0961303802724355 -0.527193822918201 0.438685064432285 MirTarget;miRNATAP -0.340653187538748 0.00200722081733701 NA NA NA hsa-miR-324-5p TGFB2 -0.993343053719004 0.00956564321262937 -0.527193822918201 0.438685064432285 miRanda -0.332468784016745 0.0111179278504267 NA NA NA hsa-miR-335-3p TGFB2 -0.496550554602651 0.223248314670008 -0.527193822918201 0.438685064432285 mirMAP -0.420588433632456 0.00061997030642565 NA NA NA hsa-miR-335-5p TGFB2 -0.913728460165869 0.0568330413961764 -0.527193822918201 0.438685064432285 miRNAWalker2_validate -0.388297631743226 0.000171392143506222 NA NA NA hsa-miR-33a-3p TGFB2 -1.71203223338714 0.000344436075634206 -0.527193822918201 0.438685064432285 MirTarget;mirMAP -0.276478939104704 0.00911116112311928 NA NA NA hsa-miR-362-3p TGFB2 -1.20829972287608 0.012574092123476 -0.527193822918201 0.438685064432285 miRanda -0.408687031842192 6.8135701026738e-05 NA NA NA hsa-miR-362-5p TGFB2 -0.73199764539445 0.112060703377193 -0.527193822918201 0.438685064432285 MirTarget -0.367018451068502 0.000698888148114626 NA NA NA hsa-miR-375 TGFB2 2.45956739868952 0.0171124871214617 -0.527193822918201 0.438685064432285 miRNAWalker2_validate -0.154751334045759 0.00119083798196993 NA NA NA hsa-miR-454-3p TGFB2 -1.26819405185127 0.00175657340513321 -0.527193822918201 0.438685064432285 MirTarget;miRNATAP -0.311386596083771 0.0114197591134241 NA NA NA hsa-miR-495-3p TGFB2 -0.819711095165138 0.0930619218141869 -0.527193822918201 0.438685064432285 MirTarget;mirMAP -0.236618091751001 0.0214532943346704 NA NA NA hsa-miR-500a-5p TGFB2 -1.10136801235297 0.0179063223236651 -0.527193822918201 0.438685064432285 mirMAP -0.296353227006286 0.0057468789564001 NA NA NA hsa-miR-500b-5p TGFB2 -1.10176568821532 0.0178708354013225 -0.527193822918201 0.438685064432285 MirTarget -0.296883902454274 0.00565577968373591 NA NA NA hsa-miR-589-3p TGFB2 -1.10182934945547 0.0255972370236888 -0.527193822918201 0.438685064432285 MirTarget -0.211614425672051 0.037691406600424 NA NA NA hsa-miR-590-3p TGFB2 -0.921957466414335 0.0345620969748757 -0.527193822918201 0.438685064432285 mirMAP -0.528742651918833 2.62682148578685e-06 NA NA NA hsa-miR-590-5p TGFB2 -0.984421368732497 0.00533663360221062 -0.527193822918201 0.438685064432285 miRanda;miRNATAP -0.581341000614029 3.38516982334321e-05 NA NA NA hsa-miR-7-5p TGFB2 0.818434078643802 0.510587133222615 -0.527193822918201 0.438685064432285 MirTarget -0.168490385759068 0.00023768506444124 NA NA NA hsa-let-7a-3p TGFB3 -0.95056529442537 0.00672174661147133 -0.815674983763687 0.225787763712969 MirTarget -0.364713296984786 0.0102596034356272 NA NA NA hsa-let-7f-1-3p TGFB3 -0.472422697135249 0.233118541405241 -0.815674983763687 0.225787763712969 MirTarget -0.418562782183665 0.000878650789228536 NA NA NA hsa-miR-151a-5p TGFB3 -0.258920387628073 0.300303161013898 -0.815674983763687 0.225787763712969 MirTarget -0.9765417974444 1.13214087578874e-06 NA NA NA hsa-miR-26b-3p TGFB3 -0.618199454225574 0.0461629753518584 -0.815674983763687 0.225787763712969 MirTarget -0.419125680036094 0.00986804345042672 NA NA NA hsa-miR-29b-3p TGFB3 -0.392267406583841 0.343581862655996 -0.815674983763687 0.225787763712969 miRTarBase -0.698451714906041 1.67865191964243e-09 NA NA NA hsa-miR-590-3p TGFB3 -0.921957466414335 0.0345620969748757 -0.815674983763687 0.225787763712969 miRanda -0.417510658886425 0.000212645387430481 NA NA NA hsa-miR-125a-5p THY1 -0.306104092733909 0.370798466662369 0.140407428851098 0.792267017750875 miRanda -0.305927432251584 0.0084531672164273 NA NA NA hsa-miR-125a-5p TLR4 -0.306104092733909 0.370798466662369 -1.1421134371091 0.0188011603114067 miRanda -0.270310809865824 0.0113433218385719 NA NA NA hsa-miR-125a-5p TMEM105 -0.306104092733909 0.370798466662369 3.35469453479487 0.000827258287677362 mirMAP -0.848772142367023 0.000113158792973456 NA NA NA hsa-miR-125a-5p TMEM123 -0.306104092733909 0.370798466662369 -0.0286607290068961 0.928136310115344 MirTarget;miRanda -0.187049972847519 0.00668054879851322 NA NA NA hsa-miR-125a-5p TMEM134 -0.306104092733909 0.370798466662369 0.185993744790241 0.567756866825462 miRanda -0.22252779980291 0.00158196172549465 NA NA NA hsa-miR-125a-5p TMEM177 -0.306104092733909 0.370798466662369 0.35537068391652 0.202592217734256 miRanda -0.180512069692833 0.00281684918815276 NA NA NA hsa-miR-125a-5p TMEM2 -0.306104092733909 0.370798466662369 -0.150571332159061 0.701008684489205 miRanda -0.499186806177444 1.09160016029971e-09 NA NA NA hsa-miR-125a-5p TMEM41A -0.306104092733909 0.370798466662369 0.43073611032481 0.0699134756521597 miRanda -0.173212774989853 0.00073473919832008 NA NA NA hsa-miR-125a-5p TMEM50A -0.306104092733909 0.370798466662369 0.102677654312986 0.616391243439626 miRanda -0.131112648585105 0.0029253704133446 NA NA NA hsa-miR-125a-5p TMEM63A -0.306104092733909 0.370798466662369 0.1288579287369 0.824128895727791 miRanda -0.670083653583358 4.48051723807702e-08 NA NA NA hsa-miR-125a-5p TMEM82 -0.306104092733909 0.370798466662369 3.11664065857223 0.00774259628437136 miRanda -0.664800371910811 0.00996470607684971 NA NA NA hsa-miR-125a-5p TMOD3 -0.306104092733909 0.370798466662369 0.317103449564031 0.361152381539518 miRanda -0.270379863559981 0.000307770865031333 NA NA NA hsa-miR-125a-5p TMPRSS13 -0.306104092733909 0.370798466662369 -0.880777518631096 0.2426301067925 miRanda;miRNATAP -0.557779407170435 0.000653668042973432 NA NA NA hsa-miR-125a-5p TMPRSS4 -0.306104092733909 0.370798466662369 5.41144930033447 0.000238286742605527 miRanda -2.16048077483622 2.89429803514113e-12 NA NA NA hsa-miR-125a-5p TNFAIP8L1 -0.306104092733909 0.370798466662369 -0.511127896545857 0.082330125167228 MirTarget;mirMAP -0.127869663226227 0.046932962368992 NA NA NA hsa-miR-125a-5p TP53 -0.306104092733909 0.370798466662369 -0.52799678906053 0.130661075040402 miRNAWalker2_validate;miRTarBase;miRanda -0.278339348800098 0.000225759076994646 26389681;21777146;23079745 Mechanistically inactivation of miR-125a during cervical carcinogenesis was caused by HPV suppression of p53 expression;In addition wild-type p53 mRNA and protein expression was increased by hsa-miR-125a-5p overexpression; Moreover blocking wild-type p53 attenuated the effect of hsa-miR-125a-5p on apoptosis; In loss-of-function experiments wild-type p53 mRNA and protein expression was decreased by blocking hsa-miR-125a-5p; The effect of hsa-miR-125a-5p inhibitor on apoptosis was also weakened by blocking wild-type p53;Furthermore treatment of HCC cells with 5-aza-2'-deoxycytidine or ectopic expression of wildtype but not mutated p53 restored miR-125a-5p and miR-125b expression and inhibited tumor cell growth suggesting their regulation by promoter methylation and p53 activity tumorigenesis;; cervical and endocervical cancer;lung cancer;liver cancer hsa-miR-421 TP53 -0.177803877528689 0.691941942432956 -0.52799678906053 0.130661075040402 miRanda -0.149316175927583 0.010142334822343 NA NA NA hsa-miR-125a-5p TPI1 -0.306104092733909 0.370798466662369 0.505031187214399 0.124476411823697 miRNAWalker2_validate -0.207278169400188 0.0037410947250633 NA NA NA hsa-miR-125a-5p TPM4 -0.306104092733909 0.370798466662369 -0.170754219164941 0.608711338055081 miRNAWalker2_validate -0.382411040067222 5.30328912420675e-08 NA NA NA hsa-miR-125a-5p TRABD -0.306104092733909 0.370798466662369 0.033271524927871 0.933112852761609 miRanda -0.209850395235167 0.0151082527333108 NA NA NA hsa-miR-125a-5p TRAK2 -0.306104092733909 0.370798466662369 -0.449817211600877 0.0577163099784222 miRanda -0.147773435957962 0.00404510249018355 NA NA NA hsa-miR-125a-5p TRAM1 -0.306104092733909 0.370798466662369 -0.0355450486875224 0.893977674405994 miRanda -0.142867460726023 0.0135233275444201 NA NA NA hsa-miR-125a-5p TRIAP1 -0.306104092733909 0.370798466662369 0.134461095085678 0.476880764220281 MirTarget;PITA;miRanda;miRNATAP -0.141860647194069 0.000440873755745573 NA NA NA hsa-miR-125a-5p TRIB1 -0.306104092733909 0.370798466662369 0.628801162738694 0.0724138825942889 MirTarget;miRanda -0.242295403557066 0.00144772658641027 NA NA NA hsa-miR-125a-5p TRIM14 -0.306104092733909 0.370798466662369 -0.167715157763613 0.594619669120553 MirTarget;PITA;miRanda -0.233719882046819 0.000587633448203415 NA NA NA hsa-miR-125a-5p TSLP -0.306104092733909 0.370798466662369 0.131859796772626 0.836772000734198 miRanda -0.276623197239378 0.0483716583214702 NA NA NA hsa-miR-125a-5p TTC38 -0.306104092733909 0.370798466662369 0.372498992628186 0.242632837742635 miRanda -0.175141864787695 0.0116266261045419 NA NA NA hsa-miR-125a-5p TTC7A -0.306104092733909 0.370798466662369 -0.0667351822163864 0.819609961157711 miRanda;miRNATAP -0.269790979396125 1.5716779097342e-05 NA NA NA hsa-miR-129-5p TTK 1.01348286569596 0.367116067584743 1.0926987820762 0.0990913054237272 miRanda -0.241935438091119 6.63893928520282e-09 NA NA NA hsa-miR-139-5p TTK -1.63574949154462 0.00653778531863944 1.0926987820762 0.0990913054237272 miRanda -0.340899680364685 1.68761581213902e-05 NA NA NA hsa-miR-338-5p TTK 0.336440913368409 0.532935762698486 1.0926987820762 0.0990913054237272 PITA -0.27449044940531 0.00241163485169086 NA NA NA hsa-miR-376a-3p TTK -0.604231855167556 0.342794419886032 1.0926987820762 0.0990913054237272 miRNAWalker2_validate -0.26730597731458 0.000513746754604821 NA NA NA hsa-miR-376a-5p TTK -1.11394176764617 0.0539029021682109 1.0926987820762 0.0990913054237272 miRNAWalker2_validate;miRTarBase -0.338190630282135 5.00497360732706e-05 NA NA NA hsa-miR-125a-5p UBA52 -0.306104092733909 0.370798466662369 -0.0530655960923827 0.846164956737576 miRanda -0.130003927941468 0.0287764490063979 NA NA NA hsa-miR-125a-5p UBAP1 -0.306104092733909 0.370798466662369 0.13422565145076 0.493351407818461 miRanda -0.101688712241193 0.0161354975960176 NA NA NA hsa-miR-125a-5p UBE2R2 -0.306104092733909 0.370798466662369 0.0705509644317992 0.711297984849262 MirTarget;PITA;miRanda;miRNATAP -0.17926683797763 8.58258832352607e-06 NA NA NA hsa-miR-125a-5p UCHL5 -0.306104092733909 0.370798466662369 0.252925168438897 0.276353140402818 miRanda -0.128436827697806 0.010708548149696 NA NA NA hsa-miR-125a-5p ULBP1 -0.306104092733909 0.370798466662369 0.760664491836086 0.266356155577733 miRanda -0.514994390306291 0.000521401914016168 NA NA NA hsa-miR-125a-5p ULBP3 -0.306104092733909 0.370798466662369 0.920008720884216 0.0514416316296537 miRanda -0.2947996467345 0.00429215201607008 NA NA NA hsa-miR-125a-5p USF1 -0.306104092733909 0.370798466662369 -0.241452681650189 0.317903131145611 miRanda -0.119803591517549 0.0224471629576306 NA NA NA hsa-miR-125a-5p USP37 -0.306104092733909 0.370798466662369 0.0955443878492774 0.68880578559619 MirTarget;PITA -0.112578301053474 0.0296144832746187 NA NA NA hsa-miR-125a-5p VASH2 -0.306104092733909 0.370798466662369 -1.63263644506487 0.00172201815580077 miRanda -0.260092936355407 0.024097357855329 NA NA NA hsa-miR-125a-5p VDAC1 -0.306104092733909 0.370798466662369 0.657777930157827 0.0134870107681524 miRanda -0.244827213648319 1.91214520359135e-05 NA NA NA hsa-miR-125a-5p VPS37B -0.306104092733909 0.370798466662369 0.320093643733783 0.330154771136653 miRNATAP -0.18388691267924 0.0101409087973284 NA NA NA hsa-miR-125a-5p VTCN1 -0.306104092733909 0.370798466662369 0.258467844874231 0.82813734323425 MirTarget;miRanda;miRNATAP -1.00060944148385 9.8272745669145e-05 NA NA NA hsa-miR-125a-5p WARS -0.306104092733909 0.370798466662369 -0.287831110656864 0.400463480885408 MirTarget;miRanda;miRNATAP -0.216817737492505 0.00352053511411283 NA NA NA hsa-miR-338-3p WEE1 0.514743230435341 0.344476371008619 -0.138491178337673 0.684041988994137 miRanda -0.16002975846551 0.000435219122390521 NA NA NA hsa-miR-125a-5p XYLT1 -0.306104092733909 0.370798466662369 -0.326471219604657 0.461290398216085 mirMAP -0.229264629575593 0.0177683539674903 NA NA NA hsa-miR-125a-5p YES1 -0.306104092733909 0.370798466662369 0.30844393059157 0.239890660494776 miRNAWalker2_validate -0.174339705686318 0.00212844723904577 NA NA NA hsa-miR-125a-5p YIPF4 -0.306104092733909 0.370798466662369 0.439161539058929 0.0506313388181079 miRNAWalker2_validate -0.184653682293306 0.000130525932024264 NA NA NA hsa-let-7b-5p YWHAE 0.133031570393829 0.651804468011451 0.148894269826762 0.446072693345021 miRNAWalker2_validate -0.118996736432571 0.0158523202450146 NA NA NA hsa-miR-100-5p YWHAE 1.02538658088665 0.0304417081584391 0.148894269826762 0.446072693345021 miRNAWalker2_validate -0.101103735888634 0.000666541701129008 NA NA NA hsa-miR-146b-5p YWHAE -1.18658780090466 0.0132247381969501 0.148894269826762 0.446072693345021 miRanda -0.153846126962051 7.84224589184713e-08 NA NA NA hsa-miR-155-5p YWHAE -1.43184489211345 0.00780837893756083 0.148894269826762 0.446072693345021 MirTarget;miRNATAP -0.160565377693426 1.28528467947454e-10 NA NA NA hsa-miR-199a-3p YWHAE -0.211495366311336 0.599453919394447 0.148894269826762 0.446072693345021 MirTarget;PITA;miRNATAP -0.199726979067938 5.58107451604765e-09 NA NA NA hsa-miR-199a-5p YWHAE -0.208670149801867 0.635984251700429 0.148894269826762 0.446072693345021 miRanda -0.219033717493874 6.84709710700894e-13 NA NA NA hsa-miR-199b-3p YWHAE -0.210629327107419 0.600966627857234 0.148894269826762 0.446072693345021 MirTarget;PITA;miRNATAP -0.199447965272027 5.87841307237278e-09 NA NA NA hsa-miR-199b-5p YWHAE 0.438479083653495 0.438925410515967 0.148894269826762 0.446072693345021 miRanda -0.159556481316961 2.04958860624985e-11 NA NA NA hsa-miR-26b-5p YWHAE -1.21629873619115 0.000852008439136243 0.148894269826762 0.446072693345021 miRNATAP -0.110506563804456 0.00433740422660528 NA NA NA hsa-miR-30a-5p YWHAE -0.588553206289925 0.175311638663077 0.148894269826762 0.446072693345021 miRNAWalker2_validate -0.117113485935688 0.00032095482198555 NA NA NA hsa-miR-30e-3p YWHAE -0.72601233034038 0.0187307130528146 0.148894269826762 0.446072693345021 miRNAWalker2_validate;MirTarget -0.139919435827376 0.00256422981834482 NA NA NA hsa-miR-320a YWHAE -0.528102551253342 0.108863315406874 0.148894269826762 0.446072693345021 miRNAWalker2_validate;MirTarget;PITA;miRanda;miRNATAP -0.161032518958287 0.000197065726527182 NA NA NA hsa-miR-148a-3p YWHAG -0.189633420648201 0.724630048925529 0.234894287154728 0.238867560210574 mirMAP -0.139541830270875 1.03626640756494e-07 NA NA NA hsa-miR-186-5p YWHAG -0.76553299921128 0.00203425234898652 0.234894287154728 0.238867560210574 mirMAP -0.178024947423978 0.00282529573167621 NA NA NA hsa-miR-30b-5p YWHAG -0.68249444596921 0.0731627218334145 0.234894287154728 0.238867560210574 miRNATAP -0.157930309235159 2.92662450224538e-05 NA NA NA hsa-miR-30c-5p YWHAG -0.877497703999593 0.00776562825190586 0.234894287154728 0.238867560210574 miRNATAP -0.177790546897443 4.82820095509639e-05 NA NA NA hsa-miR-30e-5p YWHAG -0.989157025063461 0.00041808608143741 0.234894287154728 0.238867560210574 miRNATAP -0.234799471245674 4.53271147788107e-06 NA NA NA hsa-miR-500a-5p YWHAG -1.10136801235297 0.0179063223236651 0.234894287154728 0.238867560210574 MirTarget;miRNATAP -0.125551627117097 4.29992199449807e-05 NA NA NA hsa-miR-7-1-3p YWHAG -0.729687864305395 0.0834004484481893 0.234894287154728 0.238867560210574 mirMAP -0.106539225026922 0.00196669190993201 NA NA NA hsa-miR-320a YWHAQ -0.528102551253342 0.108863315406874 -0.00107786918937247 0.994839637999925 MirTarget;PITA;miRanda;miRNATAP -0.134717498359568 0.000239922568185417 NA NA NA hsa-miR-497-5p YWHAQ -0.807147224800789 0.0207081588787015 -0.00107786918937247 0.994839637999925 MirTarget;miRNATAP -0.10509366003208 0.00238803802673538 NA NA NA hsa-miR-92a-3p YWHAQ -0.417284456385998 0.14690346065742 -0.00107786918937247 0.994839637999925 miRNAWalker2_validate -0.129148178659833 0.00243000331139279 NA NA NA hsa-miR-125a-5p YWHAZ -0.306104092733909 0.370798466662369 0.261263838029224 0.384507323118325 miRanda -0.237313863789137 0.000243400712548179 NA NA NA hsa-miR-140-3p YWHAZ -0.399322174916632 0.209443645694375 0.261263838029224 0.384507323118325 MirTarget;PITA;miRNATAP -0.156579447765215 0.0263947063701879 NA NA NA hsa-miR-30c-5p YWHAZ -0.877497703999593 0.00776562825190586 0.261263838029224 0.384507323118325 MirTarget;miRNATAP -0.139536243844062 0.0386630305199579 24519092 Involvement of miR 30c in resistance to doxorubicin by regulating YWHAZ in breast cancer cells; Together our findings provided evidence that miR-30c was one of the important miRNAs in doxorubicin resistance by regulating YWHAZ in the breast cancer cell line MCF-7/ADR drug resistance breast cancer hsa-miR-328-3p YWHAZ -0.616513764487744 0.130645662338363 0.261263838029224 0.384507323118325 MirTarget -0.224500297699494 2.67930966359905e-05 NA NA NA hsa-miR-338-5p YWHAZ 0.336440913368409 0.532935762698486 0.261263838029224 0.384507323118325 mirMAP -0.198292386045603 6.55200970431105e-07 NA NA NA hsa-miR-339-5p YWHAZ -0.916407842972803 0.0433475651700471 0.261263838029224 0.384507323118325 miRanda -0.118984456689406 0.0143190501019367 NA NA NA hsa-miR-340-3p YWHAZ -1.31095217192337 0.000384554196781826 0.261263838029224 0.384507323118325 miRNAWalker2_validate -0.213298032598967 0.000284387424364788 NA NA NA hsa-miR-361-5p YWHAZ -0.298789197467371 0.188640742693303 0.261263838029224 0.384507323118325 miRanda -0.319446230900166 0.00148745212216969 NA NA NA hsa-miR-495-3p YWHAZ -0.819711095165138 0.0930619218141869 0.261263838029224 0.384507323118325 mirMAP -0.117440975181236 0.00921696919585905 NA NA NA hsa-miR-582-5p YWHAZ -0.241398739931134 0.638696591630038 0.261263838029224 0.384507323118325 PITA -0.107192650284988 0.0125818704352905 NA NA NA hsa-miR-655-3p YWHAZ -0.970390953500819 0.0533428377775175 0.261263838029224 0.384507323118325 MirTarget -0.136277093538211 0.00181549679970494 NA NA NA hsa-miR-664a-3p YWHAZ -0.548519235569408 0.0680199398699682 0.261263838029224 0.384507323118325 mirMAP -0.303586807447137 3.58500784926394e-05 NA NA NA hsa-miR-7-1-3p YWHAZ -0.729687864305395 0.0834004484481893 0.261263838029224 0.384507323118325 mirMAP -0.226967879100469 1.05177844907104e-05 NA NA NA hsa-miR-125a-5p ZBTB7A -0.306104092733909 0.370798466662369 0.342019638434429 0.108843877277931 MirTarget;PITA -0.104861635783198 0.0234991569284395 NA NA NA hsa-miR-125a-5p ZDHHC16 -0.306104092733909 0.370798466662369 0.232733970115861 0.258130474170691 miRanda -0.172174828595432 8.8571075846987e-05 NA NA NA hsa-miR-125a-5p ZDHHC7 -0.306104092733909 0.370798466662369 0.403188697068182 0.228160745389799 miRNATAP -0.182461352127923 0.0123146602560202 NA NA NA hsa-miR-125a-5p ZDHHC9 -0.306104092733909 0.370798466662369 1.14337908963072 0.000121414898818905 miRNAWalker2_validate -0.453975485851893 2.11417277156378e-13 NA NA NA hsa-miR-125a-5p ZMYND19 -0.306104092733909 0.370798466662369 0.407974809493849 0.104711786995586 miRNAWalker2_validate -0.122887092759307 0.024845484743474 NA NA NA