miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-186-5p ADH1B 0.353452958261612 0.000145058448579496 -6.83164931597586 2.1825006679245e-42 mirMAP -0.737540828408726 0.00410537361410664 NA NA NA hsa-miR-23a-3p ADH1B 0.348231698801568 6.4911858506572e-05 -6.83164931597586 2.1825006679245e-42 mirMAP -1.23569392303588 5.99414990766793e-06 NA NA NA hsa-miR-3127-5p ADH1B 0.706677736144125 1.91821443636366e-05 -6.83164931597586 2.1825006679245e-42 MirTarget -0.561923302393454 7.91849008244032e-05 NA NA NA hsa-miR-374b-3p ADH1B 0.425603499218802 0.00146686864653282 -6.83164931597586 2.1825006679245e-42 mirMAP -0.377444156031204 0.0347277669217051 NA NA NA hsa-miR-429 ADH1B 0.559451508722375 0.00563641638673083 -6.83164931597586 2.1825006679245e-42 miRanda -0.538533300061224 3.83447165570795e-06 NA NA NA hsa-miR-450b-5p ADH1B 1.25529820885833 1.18847120528666e-15 -6.83164931597586 2.1825006679245e-42 MirTarget -1.08150725808963 6.31552911179301e-14 NA NA NA hsa-miR-500a-5p ADH1B 0.675401699376111 8.24389004707854e-05 -6.83164931597586 2.1825006679245e-42 mirMAP -0.463837182748506 0.000751349005566715 NA NA NA hsa-miR-501-5p ADH1B 1.02806906860218 1.63456814370548e-09 -6.83164931597586 2.1825006679245e-42 mirMAP -0.648417373338197 2.75671263684354e-06 NA NA NA hsa-miR-7-1-3p ADH1B 1.13646121619622 1.49823237535933e-14 -6.83164931597586 2.1825006679245e-42 mirMAP -0.848784518560539 4.62355282594962e-08 NA NA NA hsa-miR-205-3p ADIPOQ 1.2960640797621 5.80786479909147e-11 -7.62299950057215 1.67651648863075e-59 mirMAP -0.949919358646191 9.26887105653941e-18 NA NA NA hsa-miR-21-3p ADIPOQ 1.25126438776674 2.4124216716282e-17 -7.62299950057215 1.67651648863075e-59 MirTarget -1.22969773292371 5.7928152969547e-17 NA NA NA hsa-miR-320a ADIPOQ 0.801356001806321 4.91397101474502e-09 -7.62299950057215 1.67651648863075e-59 miRanda -0.997704765652852 1.15571718195483e-09 NA NA NA hsa-miR-320b ADIPOQ 1.23473838180754 3.04337566045537e-14 -7.62299950057215 1.67651648863075e-59 miRanda -0.985416424562333 3.31190349605368e-13 NA NA NA hsa-miR-330-5p ADIPOQ 0.944693925383906 5.04972895657346e-13 -7.62299950057215 1.67651648863075e-59 miRanda -0.901684294371698 1.36886626277321e-07 NA NA NA hsa-miR-339-5p ADIPOQ 1.07771430326938 2.45772601859307e-09 -7.62299950057215 1.67651648863075e-59 miRanda -0.84710021153533 6.26689247071243e-12 NA NA NA hsa-miR-429 ADIPOQ 0.559451508722375 0.00563641638673083 -7.62299950057215 1.67651648863075e-59 miRanda -0.690142350901059 7.34583244500661e-10 NA NA NA hsa-miR-501-3p ADIPOQ 0.820141346319976 1.74562930463389e-08 -7.62299950057215 1.67651648863075e-59 MirTarget -0.760889305391062 9.89215947788103e-07 NA NA NA hsa-miR-590-3p ADIPOQ 0.221436901462551 0.0965904764063157 -7.62299950057215 1.67651648863075e-59 PITA;miRanda;mirMAP -0.349448785899964 0.0443969182652306 NA NA NA hsa-miR-940 ADIPOQ 1.25303020594374 1.3005368359451e-10 -7.62299950057215 1.67651648863075e-59 MirTarget -0.748838486977075 9.23209761167479e-11 NA NA NA hsa-miR-26b-5p CA9 -0.254478038884324 0.0285227763044636 6.18079618916801 3.44270716192114e-45 miRNAWalker2_validate -0.491031814716204 0.00667480509348944 NA NA NA hsa-let-7a-3p CFTR 0.0966652362351867 0.423761916840503 -5.54143893833597 2.50537587885297e-30 MirTarget -0.391545070192474 0.0363090049536375 NA NA NA hsa-let-7f-1-3p CFTR 0.700374242293247 8.65000484720084e-08 -5.54143893833597 2.50537587885297e-30 MirTarget -0.617762101315494 0.000267823937426869 NA NA NA hsa-miR-15b-3p CFTR 1.05020782493504 6.38723677324836e-14 -5.54143893833597 2.50537587885297e-30 mirMAP -0.442759029319016 0.00468505363598715 NA NA NA hsa-miR-185-5p CFTR 0.675225177054909 1.84953949190805e-13 -5.54143893833597 2.50537587885297e-30 MirTarget -0.935397047055373 9.97556451396533e-05 NA NA NA hsa-miR-223-3p CFTR 0.406538870676709 0.0488182456956297 -5.54143893833597 2.50537587885297e-30 MirTarget -0.261159024551856 0.0162376577897224 NA NA NA hsa-miR-29a-5p CFTR 0.323252792625584 0.0370417231222825 -5.54143893833597 2.50537587885297e-30 mirMAP -0.531375827314801 0.000233479370847334 NA NA NA hsa-miR-339-5p CFTR 1.07771430326938 2.45772601859307e-09 -5.54143893833597 2.50537587885297e-30 miRanda -0.487805790771126 6.15208723185571e-05 NA NA NA hsa-miR-590-5p CFTR 0.763025362395968 3.65305892505623e-09 -5.54143893833597 2.50537587885297e-30 miRanda -0.547737930995944 0.00138030679138858 NA NA NA hsa-miR-671-5p CFTR 1.90920358947989 6.8158317757852e-31 -5.54143893833597 2.50537587885297e-30 MirTarget -1.04032483743512 5.15633997169919e-17 NA NA NA hsa-miR-944 CFTR 1.47323925060177 2.61626403984929e-13 -5.54143893833597 2.50537587885297e-30 MirTarget;PITA -0.463672295709293 1.78487633450535e-05 NA NA NA hsa-miR-421 CHST9 0.945488088619653 2.35762398527362e-09 -5.40140886265903 2.87617069192007e-21 MirTarget -0.37649866651004 0.020205409640792 NA NA NA hsa-miR-501-5p CHST9 1.02806906860218 1.63456814370548e-09 -5.40140886265903 2.87617069192007e-21 miRNATAP -0.3516323363254 0.0207136876315586 NA NA NA hsa-miR-92a-3p CHST9 0.994679542307232 1.32587679156217e-16 -5.40140886265903 2.87617069192007e-21 miRNAWalker2_validate -0.577803043104331 0.0059512889800077 NA NA NA hsa-miR-101-3p COL10A1 -1.91263766544878 1.50270129259053e-39 5.15279366152056 1.01732845234378e-36 miRNATAP -0.904738777135065 2.69767930365642e-14 NA NA NA hsa-miR-144-3p COL10A1 -1.64994343636831 1.13169944841075e-08 5.15279366152056 1.01732845234378e-36 miRNATAP -0.395429175604921 6.97941671767973e-10 NA NA NA hsa-miR-16-2-3p COL10A1 1.1567130855258 1.01867256952189e-14 5.15279366152056 1.01732845234378e-36 mirMAP -0.481655503674462 0.000105445780645138 NA NA NA hsa-miR-186-5p COL10A1 0.353452958261612 0.000145058448579496 5.15279366152056 1.01732845234378e-36 mirMAP -0.573330350630836 0.00550868119389447 NA NA NA hsa-miR-26a-5p COL10A1 -1.09269574587169 1.24020612216319e-22 5.15279366152056 1.01732845234378e-36 miRNATAP -0.646082644767841 8.38722902149565e-05 NA NA NA hsa-miR-26b-5p COL10A1 -0.254478038884324 0.0285227763044636 5.15279366152056 1.01732845234378e-36 miRNATAP -0.933202037391009 1.09797007333825e-08 NA NA NA hsa-miR-335-5p COL10A1 -1.17227779671552 1.49282618530733e-10 5.15279366152056 1.01732845234378e-36 miRNAWalker2_validate -0.442066433340862 1.46821704068908e-05 NA NA NA hsa-miR-342-3p COL10A1 0.99756868977753 9.28499866272332e-10 5.15279366152056 1.01732845234378e-36 miRanda -0.229104467906009 0.0476309118368127 NA NA NA hsa-miR-502-3p COL10A1 -0.165138869760313 0.106881047403914 5.15279366152056 1.01732845234378e-36 miRNATAP -0.865105706829384 3.71180107401257e-06 NA NA NA hsa-miR-590-3p COL10A1 0.221436901462551 0.0965904764063157 5.15279366152056 1.01732845234378e-36 miRanda;mirMAP -0.552488445193992 0.000116820343764021 NA NA NA hsa-miR-182-5p CRISP3 1.15060905311096 6.25565852529946e-10 -8.52952202057205 2.5634662605355e-42 MirTarget -0.379621231777417 0.0157134560247607 NA NA NA hsa-miR-186-5p CRISP3 0.353452958261612 0.000145058448579496 -8.52952202057205 2.5634662605355e-42 mirMAP -1.0029026477936 0.00177415953453144 NA NA NA hsa-miR-335-3p CRISP3 0.336785882180547 0.0542446207938138 -8.52952202057205 2.5634662605355e-42 mirMAP -0.392140851755727 0.0210836520967293 NA NA NA hsa-miR-3607-3p CRISP3 1.01377165357363 9.13355519701165e-05 -8.52952202057205 2.5634662605355e-42 MirTarget -0.388661510170064 0.000629032064448918 NA NA NA hsa-miR-629-3p CRISP3 1.43262037314105 2.37092217984413e-19 -8.52952202057205 2.5634662605355e-42 MirTarget -0.809291169625652 6.23527100441549e-06 NA NA NA hsa-miR-146b-5p CYP2F1 0.917975986853978 3.33749259316025e-09 -5.53548531057801 8.9006723524357e-39 miRanda -0.612758862578642 1.23874043396242e-06 NA NA NA hsa-let-7a-2-3p CYP4B1 0.00246680275221167 0.991649532156321 -5.54169400838409 1.50915352249021e-26 MirTarget -0.376014103527421 0.000260486755054842 NA NA NA hsa-miR-324-5p CYP4B1 1.66709479707179 1.45961450445769e-23 -5.54169400838409 1.50915352249021e-26 miRanda -0.621002071127698 5.10835180490767e-06 NA NA NA hsa-miR-940 CYP4B1 1.25303020594374 1.3005368359451e-10 -5.54169400838409 1.50915352249021e-26 miRNATAP -0.276090461955869 0.0235270534137637 NA NA NA hsa-miR-15a-5p DLK1 0.783550182002274 2.60699595655907e-11 -5.52733145223675 6.89299915783463e-28 miRNAWalker2_validate -0.948969448288726 9.5816766483107e-07 NA NA NA hsa-miR-130b-5p EDN3 1.77265255049999 1.43627774829684e-29 -5.70738403875405 5.1895991302336e-41 mirMAP -0.846371424153815 1.05379566748256e-12 NA NA NA hsa-miR-330-5p EDN3 0.944693925383906 5.04972895657346e-13 -5.70738403875405 5.1895991302336e-41 miRanda -0.703076599130127 2.80205398941475e-06 NA NA NA hsa-miR-450b-5p EDN3 1.25529820885833 1.18847120528666e-15 -5.70738403875405 5.1895991302336e-41 MirTarget -0.400824319814221 0.0013291843988757 NA NA NA hsa-miR-744-3p EDN3 1.18973028739247 4.23716909078104e-10 -5.70738403875405 5.1895991302336e-41 MirTarget -0.676491710175653 3.60580567052961e-11 NA NA NA hsa-miR-769-3p EDN3 0.89886491506181 2.21711828717073e-08 -5.70738403875405 5.1895991302336e-41 miRNATAP -0.538792898149228 1.44904436916325e-05 NA NA NA hsa-miR-99b-3p EDN3 0.719990421486748 1.67776350671332e-07 -5.70738403875405 5.1895991302336e-41 MirTarget -0.298748780473018 0.0399451163382587 NA NA NA hsa-miR-125a-5p FMO2 0.215366061934933 0.119550904549401 -5.30786015257352 7.42271993598698e-35 MirTarget;miRanda -0.334761593763596 0.022115593632607 NA NA NA hsa-miR-146b-5p FMO2 0.917975986853978 3.33749259316025e-09 -5.30786015257352 7.42271993598698e-35 miRanda -0.256896804722012 0.0452214652575003 NA NA NA hsa-miR-15b-3p FMO2 1.05020782493504 6.38723677324836e-14 -5.30786015257352 7.42271993598698e-35 mirMAP -0.716152726968023 2.81066966062862e-07 NA NA NA hsa-miR-182-5p FMO2 1.15060905311096 6.25565852529946e-10 -5.30786015257352 7.42271993598698e-35 MirTarget -0.479433946317513 5.90813601449481e-06 NA NA NA hsa-miR-185-5p FMO2 0.675225177054909 1.84953949190805e-13 -5.30786015257352 7.42271993598698e-35 miRNATAP -1.02671823623696 1.83373408813596e-06 NA NA NA hsa-miR-186-5p FMO2 0.353452958261612 0.000145058448579496 -5.30786015257352 7.42271993598698e-35 mirMAP -0.608483451589428 0.00521339503700446 NA NA NA hsa-miR-205-3p FMO2 1.2960640797621 5.80786479909147e-11 -5.30786015257352 7.42271993598698e-35 mirMAP -0.514472216393481 1.99519888221833e-07 NA NA NA hsa-miR-29a-5p FMO2 0.323252792625584 0.0370417231222825 -5.30786015257352 7.42271993598698e-35 mirMAP -0.409590991673075 0.00162483354577121 NA NA NA hsa-miR-421 FMO2 0.945488088619653 2.35762398527362e-09 -5.30786015257352 7.42271993598698e-35 MirTarget;miRanda -0.33427997476733 0.00791988366660073 NA NA NA hsa-miR-944 FMO2 1.47323925060177 2.61626403984929e-13 -5.30786015257352 7.42271993598698e-35 mirMAP -0.446892255719328 4.05842743261625e-06 NA NA NA hsa-miR-16-2-3p HMGCS2 1.1567130855258 1.01867256952189e-14 -6.26225776011836 2.07512917838567e-42 MirTarget -0.961173407877299 5.56544419157416e-12 NA NA NA hsa-miR-23a-5p HMGCS2 1.662156284689 7.34844237202118e-15 -6.26225776011836 2.07512917838567e-42 MirTarget -0.564619607924836 1.35692734351782e-08 NA NA NA hsa-miR-339-5p HMGCS2 1.07771430326938 2.45772601859307e-09 -6.26225776011836 2.07512917838567e-42 miRanda -0.460618885576498 9.93345311924361e-05 NA NA NA hsa-miR-590-5p HMGCS2 0.763025362395968 3.65305892505623e-09 -6.26225776011836 2.07512917838567e-42 miRanda -0.710138653190741 1.83036605121563e-05 NA NA NA hsa-let-7a-5p HOXC11 -0.439381775414001 3.1119785480023e-05 5.05226088712585 7.48227116072738e-37 TargetScan;miRNATAP -0.398535885496646 0.0249074837625964 NA NA NA hsa-let-7f-5p HOXC11 -0.441845198213823 0.00242957484218694 5.05226088712585 7.48227116072738e-37 miRNATAP -0.276408671921901 0.0314059146779222 NA NA NA hsa-let-7g-5p HOXC11 -0.250780249469264 0.00939610188330072 5.05226088712585 7.48227116072738e-37 miRNATAP -0.801041358268936 3.80298381500423e-05 NA NA NA hsa-miR-195-5p HOXC11 -1.8367376818177 6.9944883988895e-31 5.05226088712585 7.48227116072738e-37 miRNATAP -0.585782955317089 9.40737939952665e-08 NA NA NA hsa-miR-217 HOXC11 -1.35391381055929 2.42394951427902e-09 5.05226088712585 7.48227116072738e-37 PITA;miRanda -0.297958159516943 0.000227663816571139 NA NA NA hsa-miR-23b-3p HOXC11 -0.497563803223134 3.31483353357535e-05 5.05226088712585 7.48227116072738e-37 miRNATAP -1.08388890266398 1.24075286434443e-12 NA NA NA hsa-miR-27b-3p HOXC11 -0.732682718863563 2.26896143573324e-09 5.05226088712585 7.48227116072738e-37 miRNATAP -1.05775930704681 8.42276346183803e-13 NA NA NA hsa-miR-29b-2-5p HOXC11 -0.502720326849742 0.000730448246894952 5.05226088712585 7.48227116072738e-37 mirMAP -0.731053382033095 3.5384892408011e-09 NA NA NA hsa-miR-326 HOXC11 -0.425943992128769 0.0415010315530797 5.05226088712585 7.48227116072738e-37 miRanda -0.277588219183445 0.00196652169359095 NA NA NA hsa-miR-375 HOXC11 -4.24070205340868 7.48368361454041e-28 5.05226088712585 7.48227116072738e-37 miRanda;miRNATAP -0.397999504601438 1.47920163363057e-19 NA NA NA hsa-miR-491-5p HOXC11 -0.541680329196715 0.00135829217561865 5.05226088712585 7.48227116072738e-37 miRanda -0.294705287112132 0.0107735175369476 NA NA NA hsa-miR-497-5p HOXC11 -0.966244470847844 5.26505649147857e-12 5.05226088712585 7.48227116072738e-37 miRNATAP -0.592480717745568 5.4237389947329e-06 NA NA NA hsa-miR-502-3p HOXC11 -0.165138869760313 0.106881047403914 5.05226088712585 7.48227116072738e-37 miRNATAP -0.685105064870325 0.000191590879866517 NA NA NA hsa-miR-126-5p HOXD13 -0.953529188793816 7.91719143295591e-16 5.05967005609939 1.54756777715881e-22 mirMAP -0.963950472633453 5.94077394956353e-07 NA NA NA hsa-miR-26a-5p HOXD13 -1.09269574587169 1.24020612216319e-22 5.05967005609939 1.54756777715881e-22 miRNATAP -1.08713014240906 6.95585905331291e-08 NA NA NA hsa-miR-26b-5p HOXD13 -0.254478038884324 0.0285227763044636 5.05967005609939 1.54756777715881e-22 miRNATAP -0.68949937792607 0.000714673170969587 NA NA NA hsa-miR-654-3p HOXD13 -1.77960431554497 1.76486415439529e-14 5.05967005609939 1.54756777715881e-22 PITA -0.211172931717468 0.0330166882041904 NA NA NA hsa-let-7a-5p IGF2BP1 -0.439381775414001 3.1119785480023e-05 5.26983286420538 1.65944011277005e-22 miRTarBase;MirTarget;TargetScan;miRNATAP -0.641943782437469 0.00595639536155144 NA NA NA hsa-let-7b-5p IGF2BP1 -0.2489842756826 0.0211384499461719 5.26983286420538 1.65944011277005e-22 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.929717206527546 4.62768635326161e-05 NA NA NA hsa-let-7c-5p IGF2BP1 -2.07953368242668 3.46048888391218e-23 5.26983286420538 1.65944011277005e-22 MirTarget -0.464211607012421 3.18175702994727e-05 NA NA NA hsa-miR-125b-2-3p IGF2BP1 -1.87765459914049 1.24704155651697e-13 5.26983286420538 1.65944011277005e-22 mirMAP -0.329189160906694 0.000487059193309361 NA NA NA hsa-miR-125b-5p IGF2BP1 -0.993460109818276 5.07736727659894e-12 5.26983286420538 1.65944011277005e-22 mirMAP -0.485687426684208 0.00377695484990872 NA NA NA hsa-miR-126-5p IGF2BP1 -0.953529188793816 7.91719143295591e-16 5.26983286420538 1.65944011277005e-22 mirMAP -0.899574202920443 8.19051940562765e-06 NA NA NA hsa-miR-140-5p IGF2BP1 -0.412389003031485 0.000136051708543369 5.26983286420538 1.65944011277005e-22 PITA -0.477739290520192 0.0364147890326606 27588393 MicroRNA 140 5p targets insulin like growth factor 2 mRNA binding protein 1 IGF2BP1 to suppress cervical cancer growth and metastasis; Furthermore Insulin like growth factor 2 mRNA binding protein 1 IGF2BP1 was identified as a direct target of miR-140-5p and both gain-of-function and loss-of-function assays revealed that IGF2BP1 is also a functional target of miR-140-5p metastasis cervical and endocervical cancer hsa-miR-195-3p IGF2BP1 -0.624259620429699 0.000164279659144497 5.26983286420538 1.65944011277005e-22 mirMAP -0.45280358847704 0.00229408236815539 NA NA NA hsa-miR-195-5p IGF2BP1 -1.8367376818177 6.9944883988895e-31 5.26983286420538 1.65944011277005e-22 mirMAP -0.755140846892816 1.70367538311306e-07 NA NA NA hsa-miR-221-5p IGF2BP1 -0.53190793287441 0.0379158336541952 5.26983286420538 1.65944011277005e-22 miRNATAP -0.194627135144708 0.0424725034205083 NA NA NA hsa-miR-30a-3p IGF2BP1 -2.26144364746452 8.12421214153823e-31 5.26983286420538 1.65944011277005e-22 mirMAP -0.446905466496893 0.000146814137550954 NA NA NA hsa-miR-30c-2-3p IGF2BP1 -1.82791447399693 2.41509888037865e-21 5.26983286420538 1.65944011277005e-22 mirMAP -0.278899494120182 0.0229661345740099 NA NA NA hsa-miR-30e-3p IGF2BP1 -0.890635378639789 1.65740480611339e-16 5.26983286420538 1.65944011277005e-22 mirMAP -1.06559958608388 1.3788992101123e-06 NA NA NA hsa-miR-326 IGF2BP1 -0.425943992128769 0.0415010315530797 5.26983286420538 1.65944011277005e-22 miRanda;miRNATAP -0.325304515414684 0.00586286087244351 NA NA NA hsa-miR-361-3p IGF2BP1 0.272298288982435 0.0147874880476998 5.26983286420538 1.65944011277005e-22 miRNATAP -0.539222960785269 0.0149318934373242 NA NA NA hsa-miR-378a-3p IGF2BP1 -1.50453783521372 9.41694954361173e-17 5.26983286420538 1.65944011277005e-22 miRNAWalker2_validate -0.484996821941835 0.000222722192651397 NA NA NA hsa-miR-628-5p IGF2BP1 -0.554239048796013 4.92386883216087e-05 5.26983286420538 1.65944011277005e-22 miRNATAP -0.379265588407253 0.0349602703810755 NA NA NA hsa-miR-330-5p KRT13 0.944693925383906 5.04972895657346e-13 -5.14182382697353 1.59911631036766e-15 miRanda -0.577845185600958 0.00782092367554011 NA NA NA hsa-miR-339-5p KRT4 1.07771430326938 2.45772601859307e-09 -7.35183393302683 1.76304550821807e-24 miRanda -0.631513320441977 0.000422807941517975 NA NA NA hsa-miR-421 LTF 0.945488088619653 2.35762398527362e-09 -5.74276219161911 5.02912551051128e-18 miRanda -0.546858931037925 0.00345277030792352 NA NA NA hsa-miR-34c-5p MAL 0.565896455062849 0.0224052732281715 -6.08031805426112 2.6322524960792e-29 miRanda -0.217277642023442 0.0312435073295544 NA NA NA hsa-miR-326 MMP1 -0.425943992128769 0.0415010315530797 5.45402620537433 1.60255286067309e-36 miRanda -0.232971872889294 0.0167475634973837 NA NA NA hsa-miR-145-5p MMP12 -0.46917511594055 0.000685297625493134 6.88838790610627 5.81791584756413e-21 miRNAWalker2_validate -0.421754395212502 0.0482238115681261 NA NA NA hsa-miR-299-5p MMP12 -1.92445654064493 1.52402531359074e-16 6.88838790610627 5.81791584756413e-21 MirTarget -0.429634126770803 0.000461541113167236 NA NA NA hsa-miR-125b-5p MMP13 -0.993460109818276 5.07736727659894e-12 6.0102254947184 6.9657021365431e-28 miRNAWalker2_validate;miRTarBase -0.623460264337686 0.000291682087163622 25772251;23425975 This study aimed to determine the relationship between expression of miR-125b and matrix metalloproteinase 13 encoded by MMP-13 and the metastatic potential of cancer cells in NSCLC; Expression levels of miR-125b transcripts and MMP-13 proteins were analyzed by quantitative real-time PCR and immunohistochemistry respectively in tumor tissues and adjacent nontumor tissues from 42 patients with NSCLC; The interaction between miR-125b and MMP-13 expression and the associations between miR-125b and clinicopathologic data were analyzed; Additionally we have demonstrated that increased levels of miR-125b can directly downregulate MMP-13 protein expression and inhibit the invasive capabilities of cancer cells; Expression levels of miR-125b were negatively correlated with metastatic potential of NSCLC tumors which may function through regulation of MMP-13;We also provided the first evidence that miR-125b may directly target matrix metalloproteinase 13 MMP13 in bladder cancer; Our study provided evidence that miR-125b suppresses cell migration and invasion by targeting MMP13 in bladder cancer cell lines ;cell migration lung squamous cell cancer;bladder cancer hsa-miR-126-5p MMP13 -0.953529188793816 7.91719143295591e-16 6.0102254947184 6.9657021365431e-28 mirMAP -1.10997595364567 7.73519287467841e-08 NA NA NA hsa-miR-140-5p MMP13 -0.412389003031485 0.000136051708543369 6.0102254947184 6.9657021365431e-28 miRNAWalker2_validate -0.638263085767808 0.00649871935798817 NA NA NA hsa-miR-148a-3p MMP13 -0.428944290834563 0.00954246923521465 6.0102254947184 6.9657021365431e-28 MirTarget -0.82849623977104 4.22228546601879e-08 26298724 MicroRNA 148a inhibits migration of breast cancer cells by targeting MMP 13; To further explore the mechanism through which miR-148a plays its antitumor role matrix metalloproteinase-13 MMP-13 was identified as a target of miR-148a by western blot and luciferase reporter assay; Moreover silence of MMP-13 mimicked the effect of miR-148a whereas overexpression of MMP-13 rescued the impaired migration caused by miR-148a; Our study demonstrates that miR-148a inhibits the migration of breast cancer cells by targeting MMP-13 and also lays theoretical foundation for further exploration for the function of miR-148a breast cancer hsa-miR-148b-3p MMP13 0.386859166050437 4.6728211830726e-06 6.0102254947184 6.9657021365431e-28 MirTarget -0.79358788885268 0.00844340631441769 NA NA NA hsa-miR-27b-3p MMP13 -0.732682718863563 2.26896143573324e-09 6.0102254947184 6.9657021365431e-28 miRNAWalker2_validate;miRTarBase;miRNATAP -1.53812841072759 1.15917243591405e-14 NA NA NA hsa-miR-335-3p MMP13 0.336785882180547 0.0542446207938138 6.0102254947184 6.9657021365431e-28 MirTarget;mirMAP -0.721157488478598 4.9511833557737e-07 NA NA NA hsa-miR-338-3p MMP13 -0.948755228846395 8.99167125682392e-08 6.0102254947184 6.9657021365431e-28 miRanda -0.319276599150323 0.0236205925568611 NA NA NA hsa-miR-374a-5p MMP13 -0.621903385111545 6.61791773205282e-12 6.0102254947184 6.9657021365431e-28 mirMAP -1.27506516229232 3.52004126317192e-06 NA NA NA hsa-miR-374b-5p MMP13 -0.288413933608091 0.0041474558664058 6.0102254947184 6.9657021365431e-28 mirMAP -0.843108948201925 0.000849751025278266 NA NA NA hsa-miR-590-3p MMP13 0.221436901462551 0.0965904764063157 6.0102254947184 6.9657021365431e-28 miRanda;mirMAP -0.558835182727509 0.00334639814370459 NA NA NA hsa-miR-664a-3p MMP13 -0.256108763664991 0.0513188660751664 6.0102254947184 6.9657021365431e-28 MirTarget -0.394815499426255 0.0413142429069517 NA NA NA hsa-miR-9-5p MMP13 1.65694862043766 2.08325802567323e-05 6.0102254947184 6.9657021365431e-28 miRNAWalker2_validate;miRTarBase -0.439174353520323 3.41541706063957e-12 NA NA NA hsa-miR-17-5p MUC21 1.41924888736771 2.75805544953758e-18 -7.89637660108391 2.12621213926786e-27 miRNAWalker2_validate -0.718608563562951 0.000298629411966253 NA NA NA hsa-miR-199a-5p MUC21 -0.364835768178638 0.0435119211101981 -7.89637660108391 2.12621213926786e-27 MirTarget;miRanda -0.420612218662331 0.0234768382443933 NA NA NA hsa-miR-31-5p MUC21 2.79079137807505 1.72181058015659e-13 -7.89637660108391 2.12621213926786e-27 MirTarget -0.340816587826954 8.80569570832111e-05 NA NA NA hsa-miR-320a MUC21 0.801356001806321 4.91397101474502e-09 -7.89637660108391 2.12621213926786e-27 miRanda -0.858421119145352 0.000373827944503612 NA NA NA hsa-miR-320b MUC21 1.23473838180754 3.04337566045537e-14 -7.89637660108391 2.12621213926786e-27 miRanda -0.644236239318232 0.00134490169535247 NA NA NA hsa-miR-339-5p MUC21 1.07771430326938 2.45772601859307e-09 -7.89637660108391 2.12621213926786e-27 miRanda -0.65974968071714 0.000294106394662096 NA NA NA hsa-miR-450b-5p MUC21 1.25529820885833 1.18847120528666e-15 -7.89637660108391 2.12621213926786e-27 mirMAP -1.5579958439416 1.65707930753339e-14 NA NA NA hsa-miR-142-3p MUC7 1.12754191614028 1.68798138028946e-08 -6.63634312038601 1.27989085826608e-23 miRanda -0.573381103202862 0.000115655530633212 NA NA NA hsa-miR-16-2-3p MUC7 1.1567130855258 1.01867256952189e-14 -6.63634312038601 1.27989085826608e-23 mirMAP -1.19596868683497 7.92067957768053e-10 NA NA NA hsa-miR-181a-5p MUC7 0.819060835827404 1.38616688310277e-13 -6.63634312038601 1.27989085826608e-23 MirTarget -1.40897953703086 1.15192112452825e-07 NA NA NA hsa-miR-181b-5p MUC7 0.974255518824355 2.64876280203475e-16 -6.63634312038601 1.27989085826608e-23 MirTarget -1.17650063465662 1.76226651390789e-06 NA NA NA hsa-miR-542-3p MUC7 0.643308814904977 8.81635403230104e-07 -6.63634312038601 1.27989085826608e-23 MirTarget;miRanda -0.474276230794973 0.0393208390104403 NA NA NA hsa-miR-576-5p MUC7 0.940432050128373 6.90227595663302e-12 -6.63634312038601 1.27989085826608e-23 mirMAP -1.43848298919564 1.4138410332518e-11 NA NA NA hsa-miR-130b-5p MYBPC1 1.77265255049999 1.43627774829684e-29 -5.22709357754839 3.91254532780544e-11 miRNAWalker2_validate -1.14891750494561 4.16068688296668e-08 NA NA NA hsa-miR-590-3p MYBPC1 0.221436901462551 0.0965904764063157 -5.22709357754839 3.91254532780544e-11 miRanda -0.59410892957268 0.0251517400454966 NA NA NA hsa-miR-92a-3p MYH2 0.994679542307232 1.32587679156217e-16 -5.64221849570539 1.59476404789022e-09 miRNAWalker2_validate -2.20393608668185 2.39820162190477e-11 NA NA NA hsa-miR-324-5p MYOC 1.66709479707179 1.45961450445769e-23 -6.53962877389722 2.08094080050397e-59 miRanda -0.78646937683153 1.54513759097428e-12 NA NA NA hsa-miR-542-3p MYOC 0.643308814904977 8.81635403230104e-07 -6.53962877389722 2.08094080050397e-59 miRanda -0.412512930912296 0.00602635529227152 NA NA NA hsa-miR-590-3p NRAP 0.221436901462551 0.0965904764063157 -5.09959892073651 4.46604188530156e-10 miRanda -0.79376241358613 0.00366556605414029 NA NA NA hsa-miR-34c-5p PEBP4 0.565896455062849 0.0224052732281715 -5.00054224587443 2.75296608642329e-36 miRanda -0.198324121513439 0.00828603019573175 NA NA NA hsa-miR-361-5p PLA2G2A 0.0803683277369505 0.314043140368058 -5.07596668469226 1.66171761681806e-23 miRanda -0.781056988805095 0.00829293149597172 NA NA NA hsa-miR-130b-3p PLIN1 1.44628430084411 9.13980959861273e-24 -5.2091496157532 2.86905736091379e-54 mirMAP -0.751155950659459 1.76589004185986e-12 NA NA NA hsa-miR-193a-3p PLIN1 0.22120710726779 0.111827069464729 -5.2091496157532 2.86905736091379e-54 miRanda -0.232514433334022 0.0488119374909568 NA NA NA hsa-miR-330-5p PLIN1 0.944693925383906 5.04972895657346e-13 -5.2091496157532 2.86905736091379e-54 miRanda -0.640998879545224 1.26705440042596e-07 NA NA NA hsa-miR-450b-5p PLIN1 1.25529820885833 1.18847120528666e-15 -5.2091496157532 2.86905736091379e-54 miRNATAP -0.457312307209906 5.64373015046747e-06 NA NA NA hsa-miR-542-3p PLIN1 0.643308814904977 8.81635403230104e-07 -5.2091496157532 2.86905736091379e-54 miRanda -0.312044157944221 0.0119509143928187 NA NA NA hsa-miR-590-5p PLIN1 0.763025362395968 3.65305892505623e-09 -5.2091496157532 2.86905736091379e-54 miRanda -0.52777836929945 2.16890213401636e-05 NA NA NA hsa-miR-186-5p PPP1R1A 0.353452958261612 0.000145058448579496 -5.45094263195495 3.61796509192645e-31 mirMAP -0.561194068072758 0.0172666369304351 NA NA NA hsa-miR-21-3p PPP1R1A 1.25126438776674 2.4124216716282e-17 -5.45094263195495 3.61796509192645e-31 MirTarget -1.09422004768822 4.2691502633023e-15 NA NA NA hsa-miR-629-3p PPP1R1A 1.43262037314105 2.37092217984413e-19 -5.45094263195495 3.61796509192645e-31 MirTarget -1.18055797121523 1.82236094569844e-20 NA NA NA hsa-miR-146b-5p PRH2 0.917975986853978 3.33749259316025e-09 -5.11837166354163 1.0377105158429e-26 miRanda -0.447434215860642 0.00134905087728268 NA NA NA hsa-miR-455-5p PRH2 1.408595672323 5.52039116456697e-22 -5.11837166354163 1.0377105158429e-26 miRanda -0.976959176685517 5.67792327876939e-12 NA NA NA hsa-miR-629-3p PRH2 1.43262037314105 2.37092217984413e-19 -5.11837166354163 1.0377105158429e-26 MirTarget -0.484665358616585 0.000269363235772953 NA NA NA hsa-miR-205-3p SLC27A6 1.2960640797621 5.80786479909147e-11 -5.39119980085692 4.44650326340272e-37 MirTarget -0.553012600508778 1.41072215203814e-08 NA NA NA hsa-miR-452-5p SLC27A6 0.373288744398455 0.0348485937209964 -5.39119980085692 4.44650326340272e-37 MirTarget -0.373021100774818 0.000894455698212723 NA NA NA hsa-miR-590-3p SLC27A6 0.221436901462551 0.0965904764063157 -5.39119980085692 4.44650326340272e-37 miRanda;mirMAP -0.324640632399832 0.0305697139154548 NA NA NA hsa-miR-342-5p SMR3B 0.862385578881784 1.60007936373305e-08 -6.29651844122531 5.77106067074192e-42 MirTarget -0.77950990109656 3.19468362158321e-08 NA NA NA hsa-miR-142-3p STATH 1.12754191614028 1.68798138028946e-08 -7.28669773016565 9.40126027018098e-28 miRanda -0.327976396900445 0.0308085539299004 NA NA NA hsa-miR-455-5p STATH 1.408595672323 5.52039116456697e-22 -7.28669773016565 9.40126027018098e-28 miRanda -1.52386905809674 1.08296497444692e-14 NA NA NA hsa-miR-125a-3p TGM3 0.116035800853173 0.444825559956959 -5.55236846546032 1.83931706209596e-15 miRanda -0.704484296026568 0.000650815438540518 NA NA NA hsa-miR-654-3p TGM3 -1.77960431554497 1.76486415439529e-14 -5.55236846546032 1.83931706209596e-15 miRNATAP -0.265446979531782 0.0436516957199258 NA NA NA hsa-miR-18a-3p TMPRSS11B 1.82583720936229 7.51297960972179e-19 -5.80123753652794 1.25649933907594e-18 MirTarget -0.576060059932288 5.36247118827989e-05 NA NA NA hsa-miR-144-3p ZIC5 -1.64994343636831 1.13169944841075e-08 5.56784701605005 8.05188206126583e-47 MirTarget -0.18575693139452 0.00328817794531214 NA NA NA hsa-miR-299-5p ZIC5 -1.92445654064493 1.52402531359074e-16 5.56784701605005 8.05188206126583e-47 PITA -0.675736276333314 1.61434306567041e-19 NA NA NA hsa-miR-340-5p ZIC5 -0.608415693437977 4.44345153563513e-05 5.56784701605005 8.05188206126583e-47 miRNAWalker2_validate -0.280337677058151 0.0240095568191652 NA NA NA hsa-miR-375 ZIC5 -4.24070205340868 7.48368361454041e-28 5.56784701605005 8.05188206126583e-47 miRanda -0.236574881309111 1.28870868533942e-07 NA NA NA hsa-miR-382-5p ZIC5 -0.512675955239656 0.00311534081639733 5.56784701605005 8.05188206126583e-47 MirTarget -0.370773395830279 0.000512024134559282 NA NA NA hsa-miR-409-3p ZIC5 -0.342347118512604 0.0538776384301546 5.56784701605005 8.05188206126583e-47 PITA -0.322315864176737 0.00203347162275849 NA NA NA hsa-miR-486-5p ZIC5 -1.70341092285685 6.64232609099498e-14 5.56784701605005 8.05188206126583e-47 miRanda -0.342269365421331 1.53240220419403e-05 NA NA NA hsa-miR-654-3p ZIC5 -1.77960431554497 1.76486415439529e-14 5.56784701605005 8.05188206126583e-47 MirTarget;PITA -0.45865683236758 2.32105209075863e-09 NA NA NA