miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-26a-5p CCNE2 -0.963792031426845 1.83360999387345e-22 2.01834184083791 5.42527234853282e-21 miRTarBase -0.488121351666366 3.8244940657208e-06 24116110;21901171 The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression poor survival;progression pancreatic cancer;acute myeloid leukemia hsa-miR-145-5p CDK4 -1.4795885711477 6.47308361543414e-16 0.667631464196621 2.00897661385551e-11 miRTarBase -0.153089865179612 2.59222750442516e-09 21092188 Furthermore we found that CDK4 was regulated by miR-145 in cell cycle control lung squamous cell cancer hsa-miR-195-5p CDK4 -1.85907534356434 1.47434041676402e-22 0.667631464196621 2.00897661385551e-11 miRTarBase -0.181976803431634 3.34979886785679e-14 NA NA NA hsa-let-7a-5p FBXO32 -0.328069937201898 0.000464344093744051 1.49973264070402 1.35888111194844e-11 TargetScan -0.408608217233986 0.000583968456002134 NA NA NA hsa-let-7c-5p HMGA2 -1.70744661345097 2.87934212005942e-20 1.11519648679255 0.015940340984894 miRTarBase -0.682135030438129 2.57681307834063e-09 NA NA NA hsa-let-7b-5p NRAS -0.959013717270803 5.95127281258643e-11 0.301156333096785 0.000285671613438218 miRTarBase -0.105903409272711 8.57245668973746e-05 20607356 Transfection of let-7 miRNA reduced expression of pan-RAS N-RAS and K-RAS in the glioblastoma cells glioblastoma