miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-106b-5p	APC	0.0054863796897946	0.996055976715358	-0.129771633903759	0.846892723175315	miRNAWalker2_validate;miRTarBase	-0.221090416247696	2.74224832837052e-06	23087084	miR 106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma; Moreover we demonstrated that miR-106b downregulates APC expression by directly targeting the 3'-untranslated region of APC messenger RNA; Taken together our results suggest that miR-106b plays an important role in promoting the proliferation of human hepatoma cells and presents a novel mechanism of micro RNA-mediated direct suppression of APC expression in cancer cells		liver cancer
hsa-miR-148a-3p	APC	0.100907912181979	0.962574545713573	-0.129771633903759	0.846892723175315	miRNAWalker2_validate	-0.11689005190455	0.00640789868321619		NA	NA	NA
hsa-miR-154-3p	APC	0.161539340532407	0.45688019130916	-0.129771633903759	0.846892723175315	TargetScan	-0.11742585355327	0.00356137566396406		NA	NA	NA
hsa-miR-192-5p	APC	0.0697292340294755	0.973773819800855	-0.129771633903759	0.846892723175315	miRNAWalker2_validate	-0.113719244280745	0.000540682729973804		NA	NA	NA
hsa-miR-193a-3p	APC	-0.0757639382885689	0.833054724049432	-0.129771633903759	0.846892723175315	miRanda	-0.150390924294565	0.000107999447451728		NA	NA	NA
hsa-miR-27a-3p	APC	0.0343767097750227	0.981394253826582	-0.129771633903759	0.846892723175315	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.172640999838069	0.00983801888943467	22018270	Finally the APC gene was identified as the direct and functional target of miR-27		gastric cancer
hsa-miR-335-3p	APC	-0.169930485068435	0.871151368030036	-0.129771633903759	0.846892723175315	mirMAP	-0.214685562769503	6.31038682998398e-09		NA	NA	NA
hsa-miR-374a-5p	APC	-0.22568107720489	0.754040348516339	-0.129771633903759	0.846892723175315	mirMAP	-0.283252682346721	1.3727422438847e-06		NA	NA	NA
hsa-miR-374b-5p	APC	-0.266960088707788	0.755383602539075	-0.129771633903759	0.846892723175315	mirMAP	-0.202348624592442	0.000440637961909132		NA	NA	NA
hsa-miR-421	APC	-0.226934983690969	0.526580030309737	-0.129771633903759	0.846892723175315	miRanda	-0.147549411526102	0.00019991634323926		NA	NA	NA
hsa-miR-450b-5p	APC	0.148646457362083	0.720518619482493	-0.129771633903759	0.846892723175315	miRNATAP	-0.17244181378059	6.24983424543036e-05		NA	NA	NA
hsa-miR-501-3p	APC	-0.13243025930131	0.863258183297503	-0.129771633903759	0.846892723175315	TargetScan	-0.120932259670203	0.00171395840019733		NA	NA	NA
hsa-miR-590-3p	APC	0.0829620326684548	0.810708708264937	-0.129771633903759	0.846892723175315	PITA;miRanda;mirMAP;miRNATAP	-0.10191760855962	0.00339239832008087		NA	NA	NA