miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-106b-5p	TGFBR2	0.648901865047099	8.24870862047885e-09	-0.522706741081292	3.47206054315007e-05	miRNATAP	-0.368277930860382	4.29748674542316e-12		NA	NA	NA
hsa-miR-130b-3p	TGFBR2	0.687190305027546	0.000109068658562255	-0.522706741081292	3.47206054315007e-05	miRNAWalker2_validate;miRNATAP	-0.131252693120461	0.000144540113312326	25024357	Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC		lung squamous cell cancer
hsa-miR-17-5p	TGFBR2	0.698861147045461	2.43854106455398e-05	-0.522706741081292	3.47206054315007e-05	miRNAWalker2_validate;miRTarBase;TargetScan;miRNATAP	-0.203186001893041	2.94531720390227e-08	25011053;27120811	We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer	;	kidney renal cell cancer;gastric cancer
hsa-miR-18a-5p	TGFBR2	0.918028187958706	1.90229510425322e-05	-0.522706741081292	3.47206054315007e-05	miRNAWalker2_validate	-0.192780882131928	5.02272007870357e-12		NA	NA	NA
hsa-miR-19a-3p	TGFBR2	1.01712596153672	2.57753201450625e-07	-0.522706741081292	3.47206054315007e-05	miRNAWalker2_validate;miRNATAP	-0.149425406079401	1.09582904607366e-06		NA	NA	NA
hsa-miR-19b-3p	TGFBR2	0.601279551368824	0.00016685097085251	-0.522706741081292	3.47206054315007e-05	miRNAWalker2_validate;miRNATAP	-0.16137896859351	2.62064707293945e-05		NA	NA	NA
hsa-miR-20a-5p	TGFBR2	0.854326758727003	5.04256669663285e-07	-0.522706741081292	3.47206054315007e-05	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.177394018081005	6.48951647363697e-07		NA	NA	NA
hsa-miR-21-5p	TGFBR2	1.51084295924322	1.54551622173259e-34	-0.522706741081292	3.47206054315007e-05	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.236840105633096	2.41705180023436e-07	24037531	Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway		prostate cancer
hsa-miR-301a-3p	TGFBR2	0.842910511640361	1.43446467417891e-06	-0.522706741081292	3.47206054315007e-05	miRNATAP	-0.183722985598573	1.11942744399345e-07	25551793	MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2		colorectal cancer
hsa-miR-501-3p	TGFBR2	0.999540908940094	2.77358485581974e-11	-0.522706741081292	3.47206054315007e-05	TargetScan	-0.116887889145825	0.0037841236086272		NA	NA	NA
hsa-miR-590-5p	TGFBR2	-0.103355559980404	0.310027295317092	-0.522706741081292	3.47206054315007e-05	miRNAWalker2_validate;miRTarBase;PITA;miRanda;miRNATAP	-0.253149374960949	3.5308611333711e-05		NA	NA	NA
hsa-miR-92a-3p	TGFBR2	0.212391012518195	0.134292268089997	-0.522706741081292	3.47206054315007e-05	miRNAWalker2_validate	-0.17351362748106	7.02401539230513e-05		NA	NA	NA
hsa-miR-93-5p	TGFBR2	1.39518349670953	2.84167728726712e-25	-0.522706741081292	3.47206054315007e-05	miRNAWalker2_validate;miRNATAP	-0.263677361634044	7.09611188180981e-10		NA	NA	NA