miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-106a-5p	AR	1.76751200862602	7.79031604495348e-24	-0.438567054637897	0.0411236776146594	mirMAP	-0.297947321595335	1.48972994688628e-09		NA	NA	NA
hsa-miR-106b-5p	AR	1.03194006819592	5.97693261279744e-24	-0.438567054637897	0.0411236776146594	mirMAP	-0.244036003899565	0.00461358205293993		NA	NA	NA
hsa-miR-130a-3p	AR	-0.00961131533334481	0.934528436621983	-0.438567054637897	0.0411236776146594	mirMAP;miRNATAP	-0.4755854397606	9.05430038634015e-10		NA	NA	NA
hsa-miR-135a-5p	AR	1.05960103698212	1.08082165806252e-09	-0.438567054637897	0.0411236776146594	miRNATAP	-0.372294951143202	2.45284540599848e-13	26364608	We also identified robust induction of miR-135a by androgen and strong direct binding of AR to the miR-135a locus; We further demonstrate that a negative feedback loop involving miR-135a can restore AR expression under androgen-deprivation conditions thus contributing to the upregulation of AR protein expression in castration-resistant PC		prostate cancer
hsa-miR-141-3p	AR	1.79566520772935	2.4341426730525e-29	-0.438567054637897	0.0411236776146594	mirMAP	-0.266095443373697	8.03408003506303e-07	26062412;22314666	miR 141 3p regulates the expression of androgen receptor by targeting its 3'UTR in prostate cancer LNCaP cells; After prostate cancer cell line LNCaP was transfected with miR-141-3p mimics expression levels of AR mRNA and protein in the LNCaP cells were detected by reverse transcription PCR and Western blotting respectively; The 3'untranslated regions 3'UTR of AR mRNA containing the binding site of miR-141-3p was amplified by PCR and inserted into pmiR-report vector a 3'downstream luciferase reporter gene; Transfection of miR-141-3p mimics decreased both mRNA and protein expression levels of AR in LNCaP cells; AR is a direct target gene of miR-141-3p;miR 141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein; Here we investigated the correlation of Shp expression with the cellular level of miR-141 and its effects on AR transcriptional activity in non-malignant and malignant human prostate epithelial cell lines; Phenethyl isothiocyanate a natural constituent of many edible cruciferous vegetables increased Shp expression downregulated miR-141 and inhibited AR transcriptional activity in LNCaP cells; Shp is a target for miR-141 and it is downregulated in cultured human PCa cells with the involvement of upregulation of miR-141 which promotes AR transcriptional activity	;malignant trasformation	prostate cancer;prostate cancer
hsa-miR-146b-5p	AR	1.70281490248323	9.08060943822639e-35	-0.438567054637897	0.0411236776146594	mirMAP	-0.241521929141329	9.40016767558928e-05		NA	NA	NA
hsa-miR-148a-3p	AR	1.85007671007711	2.47199960189831e-52	-0.438567054637897	0.0411236776146594	mirMAP	-0.161144438153859	0.0185177484634299	27292025	We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers		prostate cancer
hsa-miR-148b-5p	AR	1.04534361724991	2.31801722055734e-12	-0.438567054637897	0.0411236776146594	mirMAP	-0.168999139291363	0.00737179315349418		NA	NA	NA
hsa-miR-149-5p	AR	0.653969866006383	3.97144325806503e-05	-0.438567054637897	0.0411236776146594	miRNATAP	-0.302279253104058	9.83374623205764e-08		NA	NA	NA
hsa-miR-155-5p	AR	0.657127495088521	1.32358745918872e-06	-0.438567054637897	0.0411236776146594	mirMAP	-0.143675448603737	0.0321054726598863		NA	NA	NA
hsa-miR-15a-5p	AR	0.922713188178758	6.51407511505232e-18	-0.438567054637897	0.0411236776146594	mirMAP;miRNATAP	-0.515529367197686	3.39845373114079e-10		NA	NA	NA
hsa-miR-16-5p	AR	0.54730888568038	1.14657883125954e-10	-0.438567054637897	0.0411236776146594	mirMAP;miRNATAP	-0.267320352043439	0.0125395313925872		NA	NA	NA
hsa-miR-17-5p	AR	1.75236465070226	3.95158641628068e-36	-0.438567054637897	0.0411236776146594	mirMAP	-0.339332247104825	2.26764421700308e-08	23095762	miR 17 5p targets the p300/CBP associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells; Targeting of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells; Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells		prostate cancer
hsa-miR-186-5p	AR	0.567811924899218	1.37607142180899e-13	-0.438567054637897	0.0411236776146594	mirMAP	-0.402071452157463	0.000638794619263266		NA	NA	NA
hsa-miR-19a-3p	AR	1.31708679186777	4.80964007387826e-14	-0.438567054637897	0.0411236776146594	mirMAP	-0.249104342566667	9.42029493433459e-07		NA	NA	NA
hsa-miR-19b-3p	AR	1.59390221063917	1.21812878827888e-26	-0.438567054637897	0.0411236776146594	mirMAP	-0.414332293377305	4.89314990482076e-13		NA	NA	NA
hsa-miR-20a-5p	AR	1.8613782696103	3.92351368893256e-34	-0.438567054637897	0.0411236776146594	mirMAP	-0.332442996578879	2.14685491165183e-09		NA	NA	NA
hsa-miR-20b-5p	AR	1.58314196476132	5.61327965534646e-17	-0.438567054637897	0.0411236776146594	mirMAP	-0.184013299260925	8.54927217613651e-05		NA	NA	NA
hsa-miR-217	AR	0.647926571365963	0.000615546232893738	-0.438567054637897	0.0411236776146594	mirMAP	-0.16803672673437	0.000487093475947384		NA	NA	NA
hsa-miR-223-3p	AR	0.483083969880508	1.66924930798402e-05	-0.438567054637897	0.0411236776146594	mirMAP	-0.205905249064471	0.011486155651508		NA	NA	NA
hsa-miR-2355-5p	AR	0.280181037431565	0.00411194169830991	-0.438567054637897	0.0411236776146594	MirTarget	-0.286392909581697	0.00234919449991941		NA	NA	NA
hsa-miR-29a-5p	AR	0.458517912323329	0.000412683536074969	-0.438567054637897	0.0411236776146594	mirMAP	-0.282411426189697	5.70964520120846e-05	26052614	A direct AR regulation of miR-22 miR-29a and miR-17-92 cluster along with their host genes was confirmed; Interestingly endogenous levels of miR-22 and miR-29a were found to be reduced in PCa cells expressing AR		prostate cancer
hsa-miR-29b-2-5p	AR	0.789021480062024	2.59438538341201e-14	-0.438567054637897	0.0411236776146594	mirMAP	-0.313100002226678	0.000295438920596515		NA	NA	NA
hsa-miR-301a-3p	AR	0.501721475120081	0.000262747397142618	-0.438567054637897	0.0411236776146594	mirMAP;miRNATAP	-0.260290074101805	8.63015559842366e-05	25940439	Mechanism dissection revealed infiltrating pre-adipocytes might function through down-regulation of the androgen receptor AR via modulation of miR-301a and then increase PCa cell invasion via induction of TGF-β1/Smad/MMP9 signals		prostate cancer
hsa-miR-3065-5p	AR	1.04645334963496	3.19942342920484e-08	-0.438567054637897	0.0411236776146594	miRNATAP	-0.105869071485612	0.0292080582526323		NA	NA	NA
hsa-miR-30a-5p	AR	0.50856224391991	3.02321261664547e-06	-0.438567054637897	0.0411236776146594	mirMAP	-0.409204826079143	8.61371867224995e-07	27683042	Results uncovered miR-30 family members as direct AR inhibitors		prostate cancer
hsa-miR-30b-5p	AR	1.16764575603669	1.75395013539888e-20	-0.438567054637897	0.0411236776146594	mirMAP	-0.558161847117231	3.51064228040788e-16	27683042	Results uncovered miR-30 family members as direct AR inhibitors		prostate cancer
hsa-miR-30c-5p	AR	0.746747513281495	1.32431877874944e-12	-0.438567054637897	0.0411236776146594	mirMAP	-0.843143058388278	7.14615300194155e-25		NA	NA	NA
hsa-miR-320a	AR	0.995486653328461	1.19389676663043e-20	-0.438567054637897	0.0411236776146594	miRNATAP	-0.729696745073191	8.96314534256615e-20	27216188	Histone Deacetylase Inhibition in Prostate Cancer Triggers miR 320 Mediated Suppression of the Androgen Receptor; Among the upregulated miRNAs after OBP-801 treatment in the three prostate cancer cell lines miR-320a whose expression was significantly correlated with prognosis of prostate cancers P = 0.0185 was the most closely associated with AR expression; An miR-320a mimic suppressed AR protein expression together with growth suppression while anti-miR-320a oligonucleotide significantly abrogated the growth suppression by OBP-801 treatment; Our data demonstrated that OBP-801 effectively suppressed AR activity via epigenetic upregulation of miR-320a which resulted in tumor cell growth suppression of prostate cancers	worse prognosis	prostate cancer
hsa-miR-335-5p	AR	0.960193718665196	5.23061119483499e-12	-0.438567054637897	0.0411236776146594	mirMAP;miRNATAP	-0.229382266863323	0.00037500457487742		NA	NA	NA
hsa-miR-338-3p	AR	0.289775600192432	0.0820821857540425	-0.438567054637897	0.0411236776146594	miRanda	-0.385550745628052	8.71514448057693e-13		NA	NA	NA
hsa-miR-34a-5p	AR	0.460660125860661	2.13400441654354e-06	-0.438567054637897	0.0411236776146594	MirTarget	-0.723330506779677	3.17126825812878e-15	24349627;22347519;21343391;25920548;25797256;23145211	In this study we found loss of miR-34a which targets AR in PCa tissue specimens especially in patients with higher Gleason grade tumors consistent with increased expression of AR; Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed reexpression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens; PCa cells treated with BR-DIM and 5-aza-dC resulted in the demethylation of miR-34a promoter concomitant with inhibition of AR and PSA expression in LNCaP and C4-2B cells; These results suggest for the first time epigenetic silencing of miR-34a in PCa which could be reversed by BR-DIM treatment and thus BR-DIM could be useful for the inactivation of AR in the treatment of PCa.This corrects the article on p;In this study we found loss of miR-34a which targets AR in PCa tissue specimens especially in patients with higher Gleason grade tumors consistent with increased expression of AR; Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed re-expression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens; PCa cells treated with BR-DIM and 5-aza-dC resulted in the demethylation of miR-34a promoter concomitant with inhibition of AR and PSA expression in LNCaP and C4-2B cells;In particular analysis of clinical prostate cancers confirmed a negative correlation of miR-34a and miR-34c expression with AR levels;To explore further the possible role of miRNAs in the AR pathway LNCaP cell line was treated with 5α-dihydrotestosterone and flutamide showing alteration in miRNAs expression especially miR-34a which was significantly underexpressed after treatment with high doses of 5α-dihydrotestosterone; Our data support a role for miRNAs especially miR-371 and miR-34a in the complex disarrangement of AR signaling pathway and in the behavior of PC;Repression of miR-34a a known AR-targeting miRNA contributes AR expression by XRN1;Inactivation of AR and Notch 1 signaling by miR 34a attenuates prostate cancer aggressiveness; We found that over-expression of miR-34a led to reduced expression of AR PSA and Notch-1; These findings suggest that the loss of miR-34a is directly linked with up-regulation of AR and Notch-1 both of which are highly expressed in PCa and thus finding innovative approaches by which miR-34a expression could be up-regulated will have a huge impact on the treatment of PCa especially for the treatment of mCRPC	;;;;;	prostate cancer;prostate cancer;prostate cancer;prostate cancer;prostate cancer;prostate cancer
hsa-miR-34c-5p	AR	0.411316782408141	0.0146968432653683	-0.438567054637897	0.0411236776146594	MirTarget	-0.244130362271932	6.67657544610356e-06	21343391	In particular analysis of clinical prostate cancers confirmed a negative correlation of miR-34a and miR-34c expression with AR levels		prostate cancer
hsa-miR-361-5p	AR	0.65220098099292	2.23302456529998e-21	-0.438567054637897	0.0411236776146594	mirMAP	-0.521352334958181	5.75468627248276e-05		NA	NA	NA
hsa-miR-362-3p	AR	0.332355427232084	0.0356765384646952	-0.438567054637897	0.0411236776146594	miRanda	-0.180197883522643	0.00211249798154022		NA	NA	NA
hsa-miR-374a-3p	AR	0.613148065516	1.92239481728524e-11	-0.438567054637897	0.0411236776146594	mirMAP	-0.326882057690765	0.000959101081336846		NA	NA	NA
hsa-miR-452-3p	AR	-0.160736173909805	0.228583481808643	-0.438567054637897	0.0411236776146594	mirMAP	-0.198908908734218	0.00422462430415619		NA	NA	NA
hsa-miR-454-3p	AR	1.05348676011504	1.08188735671639e-16	-0.438567054637897	0.0411236776146594	mirMAP;miRNATAP	-0.463953167275823	1.88480559075511e-11		NA	NA	NA
hsa-miR-505-3p	AR	-0.0131535015788877	0.895567778207462	-0.438567054637897	0.0411236776146594	mirMAP	-0.289121650238463	0.00167706203299903		NA	NA	NA
hsa-miR-505-5p	AR	0.389912091837983	0.0190993444374155	-0.438567054637897	0.0411236776146594	MirTarget	-0.136696695024138	0.0184771712666501		NA	NA	NA
hsa-miR-576-5p	AR	0.962105441345164	5.68435745070738e-14	-0.438567054637897	0.0411236776146594	mirMAP	-0.154221577858408	0.0278683273286375		NA	NA	NA
hsa-miR-582-3p	AR	0.693858322916386	6.21181920448093e-07	-0.438567054637897	0.0411236776146594	mirMAP	-0.346324125807355	8.52564090529656e-08		NA	NA	NA
hsa-miR-590-3p	AR	0.58484153433625	1.6489232844135e-06	-0.438567054637897	0.0411236776146594	mirMAP;miRNATAP	-0.20106253831716	0.00718635888376545		NA	NA	NA
hsa-miR-660-5p	AR	1.14400353328339	2.69534153134519e-19	-0.438567054637897	0.0411236776146594	mirMAP	-0.363849980192582	1.3356636996577e-07		NA	NA	NA
hsa-miR-664a-3p	AR	0.771665734879281	3.09460128204919e-14	-0.438567054637897	0.0411236776146594	mirMAP	-0.483037696126988	3.42240489024547e-08		NA	NA	NA
hsa-miR-7-1-3p	AR	1.45703750327525	1.75378847810395e-30	-0.438567054637897	0.0411236776146594	mirMAP	-0.174585210570741	0.0106206925104253		NA	NA	NA
hsa-miR-9-5p	AR	1.13944963456975	4.52386797543086e-07	-0.438567054637897	0.0411236776146594	miRNATAP	-0.208350903935233	1.60941427686006e-07		NA	NA	NA
hsa-miR-93-5p	AR	2.02673564951392	4.11722430511325e-49	-0.438567054637897	0.0411236776146594	mirMAP	-0.329886382060785	3.99162392920373e-08		NA	NA	NA