miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-106a-5p BMP2 1.3902608059488 6.07931522284525e-05 -2.20218138996674 4.40922299691684e-10 miRNATAP -0.249678598494913 2.10782040436559e-06 NA NA NA hsa-miR-106b-5p BMP2 1.47447672652218 1.32004094930462e-13 -2.20218138996674 4.40922299691684e-10 miRNATAP -0.321171575371965 7.38282859737633e-05 NA NA NA hsa-miR-142-5p BMP2 1.29672439149353 4.0768822158894e-06 -2.20218138996674 4.40922299691684e-10 PITA;miRNATAP -0.185868077906383 0.00332715123738121 NA NA NA hsa-miR-17-5p BMP2 2.07078488653279 2.77403038572568e-19 -2.20218138996674 4.40922299691684e-10 TargetScan -0.279404908743065 4.93554924874424e-05 NA NA NA hsa-miR-20a-5p BMP2 2.64649625616975 5.1469418982085e-27 -2.20218138996674 4.40922299691684e-10 miRNATAP -0.244304289249649 0.000117211326364688 NA NA NA hsa-miR-335-3p BMP2 1.51116383169018 6.88553098788624e-13 -2.20218138996674 4.40922299691684e-10 mirMAP -0.262142813909157 0.000654246945535322 NA NA NA hsa-miR-362-3p BMP2 0.194097672030785 0.52808475179225 -2.20218138996674 4.40922299691684e-10 miRanda -0.138683033488376 0.040282606792958 NA NA NA hsa-miR-421 BMP2 0.170525317701774 0.535277026680289 -2.20218138996674 4.40922299691684e-10 PITA;miRanda -0.256560714760867 8.6645740573278e-05 NA NA NA hsa-miR-590-3p BMP2 0.83851360565783 0.00129224433453587 -2.20218138996674 4.40922299691684e-10 PITA;miRanda;mirMAP -0.308279377806258 4.75756433012178e-05 NA NA NA hsa-miR-106b-5p BMP7 1.47447672652218 1.32004094930462e-13 -1.00047861355404 0.0554601667387613 mirMAP -0.447391020197377 0.000146158130647344 NA NA NA hsa-miR-130b-5p BMP7 1.53645187062942 1.10498816261505e-08 -1.00047861355404 0.0554601667387613 mirMAP -0.431434796104066 8.12236868694198e-07 NA NA NA hsa-miR-17-5p BMP7 2.07078488653279 2.77403038572568e-19 -1.00047861355404 0.0554601667387613 mirMAP -0.322736919312449 0.00129929063725447 NA NA NA hsa-miR-20a-5p BMP7 2.64649625616975 5.1469418982085e-27 -1.00047861355404 0.0554601667387613 mirMAP -0.20362911929244 0.0279524099084686 NA NA NA hsa-miR-93-5p BMP7 1.50844106515467 1.83836866996875e-12 -1.00047861355404 0.0554601667387613 mirMAP -0.274340538348203 0.0128324397409686 NA NA NA hsa-miR-532-3p CTNNB1 -0.677758187385834 0.0147557885796065 -0.0107290862071228 0.94149303042168 miRNAWalker2_validate -0.10624268556781 9.19755717985264e-06 NA NA NA hsa-miR-134-5p EPB41L5 0.169332101696567 0.622858464530849 -1.17939576453333 2.33796297415555e-10 MirTarget -0.134539176227855 8.26870716913149e-08 NA NA NA hsa-miR-148a-3p EPB41L5 2.30885799126944 1.95226081368985e-21 -1.17939576453333 2.33796297415555e-10 MirTarget -0.183457706589438 6.99339238387004e-08 NA NA NA hsa-miR-148a-5p EPB41L5 1.45633512586855 1.81792463521257e-08 -1.17939576453333 2.33796297415555e-10 mirMAP -0.136333356398964 3.85751544716495e-05 NA NA NA hsa-miR-152-3p EPB41L5 0.65734581993875 0.00129552561132481 -1.17939576453333 2.33796297415555e-10 MirTarget -0.262918912449734 4.07540259914967e-10 NA NA NA hsa-miR-424-5p EPB41L5 1.26485330287919 6.1498991028257e-06 -1.17939576453333 2.33796297415555e-10 MirTarget -0.122604000862751 6.92191298467183e-05 NA NA NA hsa-miR-590-5p EPB41L5 2.07441240363458 4.95240551694843e-14 -1.17939576453333 2.33796297415555e-10 miRanda -0.150028682749514 8.50673618618398e-05 NA NA NA hsa-miR-139-5p FAM83D -2.26625553116965 7.22375119369519e-16 2.05472082166234 2.77797438520694e-11 miRanda -0.398261661562454 2.28138302489609e-16 NA NA NA hsa-miR-3065-5p FAM83D 0.653308707552535 0.0999497219778851 2.05472082166234 2.77797438520694e-11 mirMAP -0.288768671999514 9.60872100830054e-14 NA NA NA hsa-miR-486-5p FAM83D -4.38592782786845 2.75864166493846e-29 2.05472082166234 2.77797438520694e-11 miRanda -0.20847162371427 1.24811436369951e-09 NA NA NA hsa-miR-146b-5p FGFR2 1.0922867893808 5.63754607494775e-06 -2.39472329620768 3.80959748314848e-11 miRanda -0.184601550928346 0.00873114443578221 NA NA NA hsa-miR-186-5p FGFR2 0.852175445703945 6.88885738584309e-10 -2.39472329620768 3.80959748314848e-11 miRNAWalker2_validate -0.244416512292592 0.0472067943979448 NA NA NA hsa-miR-19b-1-5p FGFR2 1.71217036351784 3.28561659177495e-12 -2.39472329620768 3.80959748314848e-11 miRNAWalker2_validate;miRTarBase -0.268412662161793 0.000607501041413817 NA NA NA hsa-miR-324-5p FGFR2 1.06955541886548 5.39722006604758e-05 -2.39472329620768 3.80959748314848e-11 miRanda -0.145174678745676 0.0234836540207274 NA NA NA hsa-miR-542-3p FGFR2 1.62226640768239 2.6427102465476e-10 -2.39472329620768 3.80959748314848e-11 miRanda -0.190402208837821 0.00349409803579517 NA NA NA hsa-miR-590-3p FGFR2 0.83851360565783 0.00129224433453587 -2.39472329620768 3.80959748314848e-11 miRanda -0.383675956139752 7.77181884190165e-07 NA NA NA hsa-miR-130b-3p FOXF2 1.83046548750752 5.04753914574694e-13 -1.69993338225277 4.29805791049164e-09 miRNATAP -0.542450390187336 2.9900842987602e-25 NA NA NA hsa-miR-142-3p FOXF2 3.98476449801341 1.56256182021111e-35 -1.69993338225277 4.29805791049164e-09 miRanda -0.144461826756793 0.00021132895771949 NA NA NA hsa-miR-182-5p FOXF2 3.21839823004635 5.13049145201115e-39 -1.69993338225277 4.29805791049164e-09 miRNAWalker2_validate;miRNATAP -0.37345075089436 3.35709919946332e-14 25738520 miR 182 promotes cell growth and invasion by targeting forkhead box F2 transcription factor in colorectal cancer; In the present study we aimed to investigate the role of miR-182 in colorectal cancer CRC and identify the regulation of FoxF2 by miR-182; The direct binding of miR-182 to the 3' untranslated region 3'UTR of FoxF2 mRNA was confirmed using a luciferase reporter gene assay colorectal cancer hsa-miR-19a-3p FOXF2 2.11776595911517 7.07663078397156e-10 -1.69993338225277 4.29805791049164e-09 miRNATAP -0.345617888842198 1.74282964727413e-14 NA NA NA hsa-miR-19b-3p FOXF2 2.10868505662119 5.40846613768389e-17 -1.69993338225277 4.29805791049164e-09 miRNATAP -0.351135935331917 7.36323115347487e-11 NA NA NA hsa-miR-200c-3p FOXF2 0.380533388300368 0.0842181838538353 -1.69993338225277 4.29805791049164e-09 miRNATAP -0.268550533940592 1.20410469266481e-05 NA NA NA hsa-miR-301a-3p FOXF2 2.70198002906399 1.56420889710984e-14 -1.69993338225277 4.29805791049164e-09 miRNATAP -0.316171075108842 3.40440398031942e-12 NA NA NA hsa-miR-429 FOXF2 2.3794516574089 1.72813419703734e-13 -1.69993338225277 4.29805791049164e-09 PITA;miRanda;miRNATAP -0.131619509808935 0.00296191172729691 NA NA NA hsa-miR-454-3p FOXF2 1.49453641052169 4.46235742871434e-09 -1.69993338225277 4.29805791049164e-09 miRNATAP -0.423615441586676 5.49820852196384e-12 NA NA NA hsa-miR-590-3p FOXF2 0.83851360565783 0.00129224433453587 -1.69993338225277 4.29805791049164e-09 PITA;miRanda -0.326916507276288 1.12388148288426e-07 NA NA NA hsa-miR-9-5p FOXF2 4.99250901331516 2.59132733422801e-19 -1.69993338225277 4.29805791049164e-09 miRNATAP -0.169681779461512 9.45070121492203e-14 NA NA NA hsa-miR-96-5p FOXF2 3.0381097138467 4.40362891630201e-24 -1.69993338225277 4.29805791049164e-09 TargetScan;miRNATAP -0.419650948632557 1.54744832634815e-18 NA NA NA hsa-miR-146b-5p GSK3B 1.0922867893808 5.63754607494775e-06 -0.319504109269896 0.00509554373726706 miRanda -0.120312213108812 1.7975506993317e-08 NA NA NA hsa-miR-181a-5p GSK3B -0.375429731222937 0.0562142867129802 -0.319504109269896 0.00509554373726706 mirMAP -0.132846513131072 5.69040547461192e-07 NA NA NA hsa-miR-181b-5p GSK3B 0.668793269169928 0.000239998092406404 -0.319504109269896 0.00509554373726706 mirMAP -0.140685251831582 8.58107584485064e-07 NA NA NA hsa-miR-199a-5p GSK3B 1.3057193856884 2.38429382751645e-08 -0.319504109269896 0.00509554373726706 PITA;miRanda;miRNATAP -0.121841478766833 2.53412001096022e-08 NA NA NA hsa-miR-199b-5p GSK3B 2.13822205171062 4.56262988762436e-15 -0.319504109269896 0.00509554373726706 PITA;miRanda;miRNATAP -0.100321514688164 5.34622168763933e-08 NA NA NA hsa-miR-26b-5p GSK3B 0.72362441215247 4.7794659748036e-05 -0.319504109269896 0.00509554373726706 miRNATAP -0.157953924331919 5.91797033962096e-08 NA NA NA hsa-miR-29a-3p GSK3B 0.101650412194573 0.573201097011668 -0.319504109269896 0.00509554373726706 miRNATAP -0.116338386401065 6.72434775060363e-05 NA NA NA hsa-miR-29b-3p GSK3B 3.10527711861309 3.01242507282711e-32 -0.319504109269896 0.00509554373726706 miRTarBase;miRNATAP -0.120996712920378 3.47881082150066e-11 NA NA NA hsa-miR-342-3p GSK3B -0.128691966564961 0.561034080130801 -0.319504109269896 0.00509554373726706 miRanda -0.118246314250764 5.34302901573344e-07 NA NA NA hsa-miR-664a-3p GSK3B 0.443077463053857 0.0214248925850984 -0.319504109269896 0.00509554373726706 mirMAP -0.143789851437302 1.0690658876804e-07 NA NA NA hsa-let-7a-3p HGF 0.167285443861993 0.431834813181487 -1.46782534168535 1.69011867186688e-05 mirMAP -0.220233871328952 0.00866054421617636 NA NA NA hsa-let-7f-1-3p HGF -0.0921261289038979 0.693970843315065 -1.46782534168535 1.69011867186688e-05 mirMAP -0.210155083903482 0.0131583763412536 NA NA NA hsa-miR-141-3p HGF 3.36993755486106 5.42939251147195e-32 -1.46782534168535 1.69011867186688e-05 MirTarget;TargetScan -0.400868595787034 1.23049606342836e-15 NA NA NA hsa-miR-200a-3p HGF 3.14766878548496 1.32850889777422e-21 -1.46782534168535 1.69011867186688e-05 MirTarget -0.253494768373625 5.0583757364239e-08 NA NA NA hsa-miR-203a-3p HGF 1.06866854356847 0.00389979689199624 -1.46782534168535 1.69011867186688e-05 MirTarget -0.153601511229596 0.000301513481806427 NA NA NA hsa-miR-26b-5p HGF 0.72362441215247 4.7794659748036e-05 -1.46782534168535 1.69011867186688e-05 MirTarget;miRNATAP -0.305370801964651 0.000589397366341262 NA NA NA hsa-miR-29a-5p HGF 1.89519956688438 1.03453349363915e-11 -1.46782534168535 1.69011867186688e-05 mirMAP -0.289655913024973 1.20483934738604e-05 NA NA NA hsa-miR-30b-5p HGF 0.358144314839612 0.138026229059594 -1.46782534168535 1.69011867186688e-05 mirMAP -0.228949192247152 0.000487341920331379 NA NA NA hsa-miR-335-3p HGF 1.51116383169018 6.88553098788624e-13 -1.46782534168535 1.69011867186688e-05 mirMAP -0.181311076961739 0.013971046838092 NA NA NA hsa-miR-421 HGF 0.170525317701774 0.535277026680289 -1.46782534168535 1.69011867186688e-05 miRanda -0.191831411356542 0.00221575379454529 NA NA NA hsa-miR-429 HGF 2.3794516574089 1.72813419703734e-13 -1.46782534168535 1.69011867186688e-05 miRanda -0.328662037767097 1.0453775228151e-10 NA NA NA hsa-miR-542-3p HGF 1.62226640768239 2.6427102465476e-10 -1.46782534168535 1.69011867186688e-05 miRanda -0.190590602252299 0.00164459151192755 NA NA NA hsa-miR-590-3p HGF 0.83851360565783 0.00129224433453587 -1.46782534168535 1.69011867186688e-05 miRanda;mirMAP -0.347975466531176 1.44513714212125e-06 NA NA NA hsa-miR-590-5p HGF 2.07441240363458 4.95240551694843e-14 -1.46782534168535 1.69011867186688e-05 miRanda -0.408173134036666 2.61219989107118e-09 NA NA NA hsa-miR-651-5p HGF 1.67013048675395 1.61458229225137e-07 -1.46782534168535 1.69011867186688e-05 MirTarget -0.277915118196018 4.80995997083731e-06 NA NA NA hsa-miR-7-1-3p HGF 2.61364240402652 1.98959237815786e-32 -1.46782534168535 1.69011867186688e-05 mirMAP -0.28714079677471 4.59341965745208e-05 NA NA NA hsa-miR-139-5p HIF1A -2.26625553116965 7.22375119369519e-16 0.422505281196834 0.0152617112253897 miRanda -0.122564563299348 8.1506141505756e-06 NA NA NA hsa-miR-195-3p HIF1A -1.33068822339418 6.65427393047357e-09 0.422505281196834 0.0152617112253897 MirTarget -0.137979401596716 6.21077876397983e-05 NA NA NA hsa-miR-320a HIF1A -0.961144925954715 1.62478794429204e-08 0.422505281196834 0.0152617112253897 miRanda -0.127052364615254 0.00664809963558903 NA NA NA hsa-miR-660-5p HIF1A 2.04875198906126 1.08269480928897e-17 0.422505281196834 0.0152617112253897 MirTarget -0.156926827151883 1.94441532644232e-06 NA NA NA hsa-let-7a-5p HMGA2 -1.37014061604018 3.11451492971224e-14 3.1216147936231 0.000109204646496434 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan -0.438068262546013 0.0310879623655268 23700794;20949044;18413822;23073586;21598109;24612219;23134218;21412931 MiR-98 a member in the let-7 family acts as a negative regulator in the expression of HMGA2 high mobility group A2 oncogene and it has been shown to have a nearly 3-fold decrease in A549/DDP cells;Since let-7 miRNAs generally play a tumor-suppressive role as targeting oncogenes such as RAS and HMGA2 our results suggest that AZ-P7a cells release let-7 miRNAs via exosomes into the extracellular environment to maintain their oncogenesis;Recent studies report that HMGA2 is negatively regulated by the let-7 microRNA miRNA family; However no studies have examined the clinical significance of HMGA2 and its relationship to the let-7 miRNA family in gastric cancer; We also did an association study comparing HMGA2 expression and let-7 miRNA family expression in gastric cancer; An inverse correlation between HMGA2 and let-7a was found in gastric cancer cell lines P = 0.08; Furthermore our findings suggest that HMGA2 is negatively regulated by the let-7 miRNA family in human gastric cancer;HMGA2 mRNA and let-7 family microRNA were detected by real time fluorescent quantitative reverse transcription polymerase chain reaction in the corresponding frozen tissues; All let-7 family members were detectable in all ovarian cancer samples and their expression were inversely correlated with HMGA2 mRNA expression r=-0.305P<0.05; The downregulation of let-7 is but not the only mechanism of HMGA2 overexpression in serous ovarian cancer;Role of microRNA let 7 and effect to HMGA2 in esophageal squamous cell carcinoma; To investigated the role of microRNA miRNA let-7 and its regulation on high mobility group A2 HMGA2 protein expression in esophageal squamous cell carcinoma ESCC; To evaluate the role of let-7 and HMGA2 cell proliferations were analyzed with synthetic let-7 mimics- or its inhibitor-transfected cells; The transcription of let-7 inversely correlated with HMGA2 protein; The present results demonstrated that let-7 and HMGA2 involved in ESCC carcinogenesis;HMGA2 is down regulated by microRNA let 7 and associated with epithelial mesenchymal transition in oesophageal squamous cell carcinomas of Kazakhs; To investigate the expression of let-7 and its regulation of high-mobility group A2 protein HMGA2 and to verify the relationship between let-7 HMGA2 and the process of epithelial-mesenchymal transition EMT in oesophageal squamous cell carcinomas OSCC of Kazakh patients; Let-7 could repress expression of HMGA2 after co-transfection with let-7 and HMGA2 P = 0.002; Moreover let-7 expression was observed less frequently P = 2.0 × 10-8 and HMGA2 expression more frequently P = 1.0 × 10-10 in OSCC than in normal adjacent tissues; and let-7 expression was observed less frequently in OSCC from Kazakh patients than in those from Han and Uygur patients P = 0.041; There was a reverse correlation between expression of let-7 and HMGA2 P = 0.018; Expression of let-7 can suppress cell proliferation by acting directly on regulation of HMGA2 in OSCC;MicroRNA let 7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K Ras and HMGA2 gene expression; K-RAS and HMGA2 mRNA levels were significantly higher in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; However the protein levels of K-RAS and HMGA2 were significantly lower in the let-7a overexpressed group than those in the let-7a inhibited group p < 0.05; We suppose that let-7a inhibits the proliferation and invasion of the cell line 95D by regulating the translation of K-RAS and HMGA2 mRNA not the transcription of the mRNA itself;Let 7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic data; The aim of our study was first to assess the role of HMGA2 expression in the pathogenesis of adipocytic tumors AT and second to seek a potential correlation between overexpression of HMGA2 and let-7 expression inhibition by analyzing a series of 56 benign and malignant AT with molecular cytogenetic data; We measured the levels of expression of HMGA2 mRNA and of eight members of the let-7 microRNA family using quantitative RT-PCR and expression of HMGA2 protein using immunohistochemistry; Although overexpression of both HMGA2 mRNA and protein in a majority of ordinary lipomas without HMGA2 structural rearrangement may have suggested a potential role for let-7 microRNAs we did not observe a significant link with let-7 inhibition in such cases ;;;;tumorigenesis;;;malignant trasformation lung cancer;gastric cancer;gastric cancer;ovarian cancer;esophageal cancer;esophageal cancer;lung squamous cell cancer;sarcoma hsa-let-7b-5p HMGA2 -1.62016148171663 1.56547487335694e-15 3.1216147936231 0.000109204646496434 miRNAWalker2_validate;miRTarBase;MirTarget -0.364007615057347 0.042560060620803 23700794;20949044;18413822;23073586;21598109;24612219;21412931 MiR-98 a member in the let-7 family acts as a negative regulator in the expression of HMGA2 high mobility group A2 oncogene and it has been shown to have a nearly 3-fold decrease in A549/DDP cells;Since let-7 miRNAs generally play a tumor-suppressive role as targeting oncogenes such as RAS and HMGA2 our results suggest that AZ-P7a cells release let-7 miRNAs via exosomes into the extracellular environment to maintain their oncogenesis;Recent studies report that HMGA2 is negatively regulated by the let-7 microRNA miRNA family; However no studies have examined the clinical significance of HMGA2 and its relationship to the let-7 miRNA family in gastric cancer; We also did an association study comparing HMGA2 expression and let-7 miRNA family expression in gastric cancer; Furthermore our findings suggest that HMGA2 is negatively regulated by the let-7 miRNA family in human gastric cancer;HMGA2 mRNA and let-7 family microRNA were detected by real time fluorescent quantitative reverse transcription polymerase chain reaction in the corresponding frozen tissues; All let-7 family members were detectable in all ovarian cancer samples and their expression were inversely correlated with HMGA2 mRNA expression r=-0.305P<0.05; The downregulation of let-7 is but not the only mechanism of HMGA2 overexpression in serous ovarian cancer;Role of microRNA let 7 and effect to HMGA2 in esophageal squamous cell carcinoma; To investigated the role of microRNA miRNA let-7 and its regulation on high mobility group A2 HMGA2 protein expression in esophageal squamous cell carcinoma ESCC; To evaluate the role of let-7 and HMGA2 cell proliferations were analyzed with synthetic let-7 mimics- or its inhibitor-transfected cells; The transcription of let-7 inversely correlated with HMGA2 protein; The present results demonstrated that let-7 and HMGA2 involved in ESCC carcinogenesis;HMGA2 is down regulated by microRNA let 7 and associated with epithelial mesenchymal transition in oesophageal squamous cell carcinomas of Kazakhs; To investigate the expression of let-7 and its regulation of high-mobility group A2 protein HMGA2 and to verify the relationship between let-7 HMGA2 and the process of epithelial-mesenchymal transition EMT in oesophageal squamous cell carcinomas OSCC of Kazakh patients; Let-7 could repress expression of HMGA2 after co-transfection with let-7 and HMGA2 P = 0.002; Moreover let-7 expression was observed less frequently P = 2.0 × 10-8 and HMGA2 expression more frequently P = 1.0 × 10-10 in OSCC than in normal adjacent tissues; and let-7 expression was observed less frequently in OSCC from Kazakh patients than in those from Han and Uygur patients P = 0.041; There was a reverse correlation between expression of let-7 and HMGA2 P = 0.018; Expression of let-7 can suppress cell proliferation by acting directly on regulation of HMGA2 in OSCC;Let 7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic data; The aim of our study was first to assess the role of HMGA2 expression in the pathogenesis of adipocytic tumors AT and second to seek a potential correlation between overexpression of HMGA2 and let-7 expression inhibition by analyzing a series of 56 benign and malignant AT with molecular cytogenetic data; We measured the levels of expression of HMGA2 mRNA and of eight members of the let-7 microRNA family using quantitative RT-PCR and expression of HMGA2 protein using immunohistochemistry; Although overexpression of both HMGA2 mRNA and protein in a majority of ordinary lipomas without HMGA2 structural rearrangement may have suggested a potential role for let-7 microRNAs we did not observe a significant link with let-7 inhibition in such cases ;;;;tumorigenesis;;malignant trasformation lung cancer;gastric cancer;gastric cancer;ovarian cancer;esophageal cancer;esophageal cancer;sarcoma hsa-let-7c-5p HMGA2 -2.14139413005852 1.66416999341685e-18 3.1216147936231 0.000109204646496434 miRNAWalker2_validate;miRTarBase;MirTarget -0.318728726736024 0.0313633808768461 NA NA NA hsa-let-7d-5p HMGA2 -0.618145137285851 6.06067642715858e-05 3.1216147936231 0.000109204646496434 miRNAWalker2_validate;miRTarBase;MirTarget -0.653512502224848 0.00736369567416333 NA NA NA hsa-let-7g-5p HMGA2 0.0837630831079359 0.583083118232597 3.1216147936231 0.000109204646496434 miRNAWalker2_validate;miRTarBase;MirTarget -0.581868129052978 0.019313263241758 21472347;18308936 Furthermore K-Ras and HMGA2 are well known as targets of let-7g; In this study we evaluated the potential role of precursor pre-let-7g in lung cancer cell metastasis focusing on the two targets of let-7g HMGA2 and K-Ras;In let-7g expressing tumors reductions in Ras family and HMGA2 protein levels were detected; Ectopic expression of K-RasG12D largely rescued let-7g mediated tumor suppression whereas ectopic expression of HMGA2 was less effective metastasis; lung cancer;lung cancer hsa-miR-129-5p HMGA2 -0.405735314747643 0.341485636033577 3.1216147936231 0.000109204646496434 miRanda;mirMAP -0.204506630173137 0.0205065168858647 NA NA NA hsa-miR-195-3p HMGA2 -1.33068822339418 6.65427393047357e-09 3.1216147936231 0.000109204646496434 mirMAP -0.433251996242442 0.00729907196808592 NA NA NA hsa-miR-195-5p HMGA2 -1.01577502605386 4.80814718341729e-05 3.1216147936231 0.000109204646496434 MirTarget -0.454729933704072 0.00378289939018978 NA NA NA hsa-miR-204-5p HMGA2 -1.01965803752657 0.00767207541525746 3.1216147936231 0.000109204646496434 miRNATAP -0.276708240491669 0.00500202736982316 27095441;26406941 We identified high mobility group protein A2 HMGA2 as a novel direct target of miR-204 and showed that miR-204 expression was decreased while HMGA2 expression was increased in CRC cell lines; Additionally both MiR-204 overexpression and HMGA2 inhibition attenuated cell proliferation whereas forced expression of HMGA2 partly restored the inhibitory effect of miR-204 on HCT116 and SW480 cells; Taken together our present study elucidated that miR-204 upregulated 5-Fu chemosensitivity via the downregulation of HMGA2 in colorectal cancer and provided significant insight into the mechanism of 5-Fu resistance in colorectal cancer patients;MiR 204 regulates HMGA2 expression and inhibits cell proliferation in human thyroid cancer; Analysis using publicly available algorithms has found that high mobility group AT-hook 2 HMGA2 a key transcriptional regulatory factor is a potential target of microRNA-204 miR-204; Some studies have shown that both miR-204 and HMGA2 are associated with cancer development; We examined the possible relationship between miR-204 and HMGA2 in the development of thyroid cancer; MiR-204 was downregulated in the thyroid cancer specimens and cell lines and targeted the 3^\prime untranslated region of HMGA2 directly drug resistance; colorectal cancer;thyroid cancer hsa-miR-26b-5p HMGA2 0.72362441215247 4.7794659748036e-05 3.1216147936231 0.000109204646496434 miRNATAP -0.461729691772975 0.0283690278760885 NA NA NA hsa-miR-29b-2-5p HMGA2 0.345881055247341 0.194842633194187 3.1216147936231 0.000109204646496434 mirMAP -0.686567203188141 8.24883505532676e-07 NA NA NA hsa-miR-3065-5p HMGA2 0.653308707552535 0.0999497219778851 3.1216147936231 0.000109204646496434 mirMAP;miRNATAP -0.245625274034443 0.0166094023404185 NA NA NA hsa-miR-30b-5p HMGA2 0.358144314839612 0.138026229059594 3.1216147936231 0.000109204646496434 mirMAP -0.657872918611998 2.06886209252783e-05 NA NA NA hsa-miR-30c-5p HMGA2 -0.327319105755825 0.123595832152687 3.1216147936231 0.000109204646496434 mirMAP -0.443872305827072 0.0121262723816964 NA NA NA hsa-miR-30d-3p HMGA2 0.00396376345349925 0.986457040013182 3.1216147936231 0.000109204646496434 MirTarget -0.825440078445843 4.06604085734449e-06 NA NA NA hsa-miR-30d-5p HMGA2 -0.920901858717441 3.50898334321668e-05 3.1216147936231 0.000109204646496434 mirMAP -1.02629802668181 4.60342676144683e-10 NA NA NA hsa-miR-32-5p HMGA2 0.876853679269853 6.04859399018691e-05 3.1216147936231 0.000109204646496434 miRNATAP -0.508822848697839 0.0060268795974384 NA NA NA hsa-miR-326 HMGA2 -0.992397386750901 0.00335173765975096 3.1216147936231 0.000109204646496434 miRNATAP -0.419277790137841 0.000134273505177952 NA NA NA hsa-miR-362-3p HMGA2 0.194097672030785 0.52808475179225 3.1216147936231 0.000109204646496434 miRanda -0.322020712402065 0.0349115996740198 NA NA NA hsa-miR-486-5p HMGA2 -4.38592782786845 2.75864166493846e-29 3.1216147936231 0.000109204646496434 miRanda -0.24472813822788 0.00642108022242592 NA NA NA hsa-miR-491-5p HMGA2 -0.472928614372062 0.0683344127929203 3.1216147936231 0.000109204646496434 PITA;miRanda -0.347535429384489 0.0169480126685681 NA NA NA hsa-miR-664a-3p HMGA2 0.443077463053857 0.0214248925850984 3.1216147936231 0.000109204646496434 mirMAP -0.926995360507061 1.68109787948392e-06 NA NA NA hsa-miR-664a-5p HMGA2 -0.0936480603578111 0.662274905077117 3.1216147936231 0.000109204646496434 MirTarget -0.727337060964839 5.0657603304685e-05 NA NA NA hsa-miR-139-5p HNRNPAB -2.26625553116965 7.22375119369519e-16 0.650584995890659 4.11362869085326e-08 miRanda -0.115941976629469 5.89174093472053e-10 NA NA NA hsa-miR-107 LEF1 0.658676029898313 5.11480446318819e-07 0.588024418569192 0.00773878613348744 miRanda -0.262842866172606 0.000738685814950871 NA NA NA hsa-miR-26b-5p LEF1 0.72362441215247 4.7794659748036e-05 0.588024418569192 0.00773878613348744 miRNATAP -0.139368195747163 0.0149967116356259 24785257 miR26b is downregulated in several cancers and tumors and miR26b directly targets the lymphoid enhancer factor 1 Lef13'UTR and inhibits endogenous Lef1 expression; We report that miR26b expression is associated with human colon cancer through the regulation of LEF1 expression in colon cancer cells; Analyses of multiple colon cancer cell lines revealed an inverse correlation between miR26b and LEF1 expression; Normal human colon cells express low levels of LEF1 and high levels of miR26b; however human colon cancer cells have decreased miR26b expression and increased LEF1 expression; We demonstrate that miR26b expression is a potent inhibitor of colon cancer cell proliferation and significantly decreases LEF1 expression; Analyses of human colon cancer databases also demonstrated a link between miR26b and LEF1 expression colon cancer hsa-miR-3065-3p LEF1 0.381740717819351 0.30795546546997 0.588024418569192 0.00773878613348744 miRNATAP -0.11840997118237 1.18212026315203e-05 NA NA NA hsa-miR-3065-5p LEF1 0.653308707552535 0.0999497219778851 0.588024418569192 0.00773878613348744 miRNATAP -0.130781255877128 2.27551750259261e-06 NA NA NA hsa-miR-335-3p LEF1 1.51116383169018 6.88553098788624e-13 0.588024418569192 0.00773878613348744 mirMAP -0.105266359692155 0.026487337390556 NA NA NA hsa-let-7a-3p LIMS1 0.167285443861993 0.431834813181487 -0.704394644273366 0.000151942952769563 mirMAP -0.154818061995388 0.000658598259957072 NA NA NA hsa-miR-148b-5p LIMS1 1.39335695292409 2.13220380550073e-07 -0.704394644273366 0.000151942952769563 MirTarget -0.212715143676944 1.48545621670837e-08 NA NA NA hsa-miR-182-5p LIMS1 3.21839823004635 5.13049145201115e-39 -0.704394644273366 0.000151942952769563 MirTarget;miRNATAP -0.116706632584588 0.000265604241402123 NA NA NA hsa-miR-186-5p LIMS1 0.852175445703945 6.88885738584309e-10 -0.704394644273366 0.000151942952769563 mirMAP -0.231508294321222 0.000181304329141218 NA NA NA hsa-miR-29a-3p LIMS1 0.101650412194573 0.573201097011668 -0.704394644273366 0.000151942952769563 MirTarget;miRNATAP -0.177337200983816 0.00021744548333673 NA NA NA hsa-miR-29b-3p LIMS1 3.10527711861309 3.01242507282711e-32 -0.704394644273366 0.000151942952769563 MirTarget;miRNATAP -0.245934794675201 9.2138107909387e-17 NA NA NA hsa-miR-30b-5p LIMS1 0.358144314839612 0.138026229059594 -0.704394644273366 0.000151942952769563 MirTarget -0.318684653144228 1.48285342468069e-20 NA NA NA hsa-miR-30c-5p LIMS1 -0.327319105755825 0.123595832152687 -0.704394644273366 0.000151942952769563 MirTarget -0.281666092052092 1.40373562873455e-12 NA NA NA hsa-miR-30d-3p LIMS1 0.00396376345349925 0.986457040013182 -0.704394644273366 0.000151942952769563 mirMAP -0.163462863414886 7.63302303983014e-05 NA NA NA hsa-miR-30d-5p LIMS1 -0.920901858717441 3.50898334321668e-05 -0.704394644273366 0.000151942952769563 MirTarget -0.136684581204048 0.00037252941544179 NA NA NA hsa-miR-30e-5p LIMS1 1.60414100786743 3.78951090573667e-19 -0.704394644273366 0.000151942952769563 MirTarget -0.172467094209711 0.000191499503202009 NA NA NA hsa-miR-429 LIMS1 2.3794516574089 1.72813419703734e-13 -0.704394644273366 0.000151942952769563 miRanda;miRNATAP -0.219426502969477 9.2011762500756e-16 NA NA NA hsa-miR-7-1-3p LIMS1 2.61364240402652 1.98959237815786e-32 -0.704394644273366 0.000151942952769563 mirMAP -0.11360852942109 0.00311324265160788 NA NA NA hsa-miR-96-5p LIMS1 3.0381097138467 4.40362891630201e-24 -0.704394644273366 0.000151942952769563 TargetScan;miRNATAP -0.231724120168085 3.95894899465575e-14 NA NA NA hsa-miR-338-3p LOXL2 0.726843067232002 0.0506251324215494 1.02453455700776 0.00102666255501673 miRanda -0.182067664779427 2.18427937540856e-06 NA NA NA hsa-let-7a-5p LOXL3 -1.37014061604018 3.11451492971224e-14 -0.112077981669739 0.58907472330164 miRNATAP -0.189243333907741 0.00024017297444423 NA NA NA hsa-let-7d-5p LOXL3 -0.618145137285851 6.06067642715858e-05 -0.112077981669739 0.58907472330164 miRNATAP -0.194943185708576 0.00167829110081797 NA NA NA hsa-let-7e-5p LOXL3 -0.749418249305995 7.34668338492227e-05 -0.112077981669739 0.58907472330164 miRNATAP -0.110381652645657 0.0287940934059639 NA NA NA hsa-let-7f-5p LOXL3 -0.0523311272618407 0.83407808268787 -0.112077981669739 0.58907472330164 miRNATAP -0.168037951421307 1.00894310131105e-05 NA NA NA hsa-let-7g-5p LOXL3 0.0837630831079359 0.583083118232597 -0.112077981669739 0.58907472330164 miRNATAP -0.188439276028349 0.00289371613849067 NA NA NA hsa-miR-2110 LOXL3 -1.92124860612475 1.1464887721828e-12 -0.112077981669739 0.58907472330164 miRNATAP -0.142209142234793 3.98855787205931e-05 NA NA NA hsa-miR-142-5p NOG 1.29672439149353 4.0768822158894e-06 -0.699333310369287 0.111798759846013 miRNATAP -0.182416427642032 0.0186098089582553 NA NA NA hsa-miR-186-5p NOG 0.852175445703945 6.88885738584309e-10 -0.699333310369287 0.111798759846013 MirTarget;miRNATAP -0.356485390711327 0.0147443581907703 NA NA NA hsa-miR-200c-3p NOG 0.380533388300368 0.0842181838538353 -0.699333310369287 0.111798759846013 MirTarget;miRNATAP -0.239591503736139 0.00943576516094194 NA NA NA hsa-miR-28-5p NOTCH1 1.19639196514745 4.59365801666536e-18 -1.08143915688675 1.91432645589515e-09 miRanda -0.236155185934845 6.90789991533733e-05 NA NA NA hsa-miR-664a-3p RBPJ 0.443077463053857 0.0214248925850984 0.0748708694049576 0.550190272012985 mirMAP -0.126612927312987 2.13527079650223e-05 NA NA NA hsa-let-7a-3p SNAI1 0.167285443861993 0.431834813181487 -0.758705608706721 0.00279194957161285 miRNATAP -0.145599632531001 0.0190522679654119 NA NA NA hsa-miR-26b-5p SNAI1 0.72362441215247 4.7794659748036e-05 -0.758705608706721 0.00279194957161285 miRNAWalker2_validate -0.164161540512152 0.0127754685445355 NA NA NA hsa-miR-30a-5p SNAI1 -0.924084264430689 0.000762030454634728 -0.758705608706721 0.00279194957161285 miRTarBase;miRNATAP -0.141182515684594 0.000887118488091277 24954667;27212164;21633953 We identified SNAI1 as a direct target of miR-30a and demonstrated miR-30a as a novel regulator of EMT by targeting SNAI1 indicating its potential therapeutic value for reducing invasion and metastasis of HCC;Knockdown of endogenous miR-30a promoted the elongated fibroblast-like morphologic alteration of SGC-7901 cells and also enhanced Snail and Vimentin expression; MiR-30a overexpression induced morphological changes from an extended fibroblast-like morphology to more epithelial-like morphology in SGC-7901/DDP cells and decreased Snail and Vimentin level;MicroRNA 30a inhibits epithelial to mesenchymal transition by targeting Snai1 and is downregulated in non small cell lung cancer; Forced re-introduction of miR-30a significantly altered cell morphology in vitro invasion and migration of invasive cell lines this being paralleled by a downregulation of Snai1 and upregulation of E-cadherin expression; These results suggest that miR-30a targets Snai1 inhibits invasion and metastasis and is downregulated in NSCLC metastasis;;metastasis liver cancer;gastric cancer;lung squamous cell cancer hsa-miR-30b-5p SNAI1 0.358144314839612 0.138026229059594 -0.758705608706721 0.00279194957161285 miRTarBase;miRNATAP -0.291283315188712 1.21647775577077e-09 NA NA NA hsa-miR-30c-5p SNAI1 -0.327319105755825 0.123595832152687 -0.758705608706721 0.00279194957161285 miRTarBase;miRNATAP -0.238492825243544 1.48161090880448e-05 NA NA NA hsa-miR-30d-5p SNAI1 -0.920901858717441 3.50898334321668e-05 -0.758705608706721 0.00279194957161285 miRTarBase;miRNATAP -0.401048348988449 3.55909231286861e-15 26501435 miR 30d Blocked Transforming Growth Factor β1 Induced Epithelial Mesenchymal Transition by Targeting Snail in Ovarian Cancer Cells; Luciferase activity assay was performed to verify the direct inhibition of Snail by miR-30d; Furthermore Snail was identified as the direct target of miR-30d; Our results revealed that miR-30d functioned as a suppressor of ovarian cancer progression by decreasing Snail expression and thus blocking TGF-β1-induced EMT process suggesting the potentiality of miR-30d analogs to be used as therapeutics for ovarian cancer progression ovarian cancer hsa-miR-30e-5p SNAI1 1.60414100786743 3.78951090573667e-19 -0.758705608706721 0.00279194957161285 miRTarBase -0.295160445755265 2.50402165431646e-06 NA NA NA hsa-miR-335-5p SNAI1 -0.466533891325811 0.0676987038122831 -0.758705608706721 0.00279194957161285 miRNAWalker2_validate -0.159640747752085 0.0019015751667729 NA NA NA hsa-miR-107 SNAI2 0.658676029898313 5.11480446318819e-07 -0.554815854836026 0.0572510642413704 miRanda -0.453280671767904 9.47828797287328e-06 NA NA NA hsa-miR-148b-3p SNAI2 0.483970528590224 0.0026495409465901 -0.554815854836026 0.0572510642413704 miRNAWalker2_validate -0.556715968710761 1.39573841121991e-11 NA NA NA hsa-miR-181a-5p SNAI2 -0.375429731222937 0.0562142867129802 -0.554815854836026 0.0572510642413704 miRNAWalker2_validate -0.139428485291248 0.042854346633008 NA NA NA hsa-miR-182-5p SNAI2 3.21839823004635 5.13049145201115e-39 -0.554815854836026 0.0572510642413704 miRNAWalker2_validate;miRNATAP -0.27996146293031 1.54370882600273e-08 NA NA NA hsa-miR-200b-3p SNAI2 1.55157578247391 4.83790020897188e-09 -0.554815854836026 0.0572510642413704 TargetScan -0.443484841265163 2.179079103861e-20 NA NA NA hsa-miR-200c-3p SNAI2 0.380533388300368 0.0842181838538353 -0.554815854836026 0.0572510642413704 miRNATAP -0.454021736927152 2.59527605282676e-14 NA NA NA hsa-miR-335-3p SNAI2 1.51116383169018 6.88553098788624e-13 -0.554815854836026 0.0572510642413704 mirMAP -0.277154551162383 8.12434222553235e-06 NA NA NA hsa-miR-375 SNAI2 0.615547997686534 0.149199273675144 -0.554815854836026 0.0572510642413704 miRanda -0.275636396308253 7.67532856156687e-20 NA NA NA hsa-miR-429 SNAI2 2.3794516574089 1.72813419703734e-13 -0.554815854836026 0.0572510642413704 PITA;miRanda;miRNATAP -0.340017457669358 1.60139306581284e-15 NA NA NA hsa-miR-532-5p SNAI2 0.576620898517708 0.0023245812680956 -0.554815854836026 0.0572510642413704 PITA -0.391801913447513 2.51582546466248e-08 NA NA NA hsa-miR-96-5p SNAI2 3.0381097138467 4.40362891630201e-24 -0.554815854836026 0.0572510642413704 miRNATAP -0.265643619461592 4.47304111611125e-08 NA NA NA hsa-miR-335-3p SOX9 1.51116383169018 6.88553098788624e-13 0.496282649979264 0.278221405607501 mirMAP -0.269233482998866 0.00600561407900789 NA NA NA hsa-miR-590-3p SOX9 0.83851360565783 0.00129224433453587 0.496282649979264 0.278221405607501 PITA;miRanda;mirMAP;miRNATAP -0.203130187853628 0.0362124821211825 NA NA NA hsa-miR-107 TGFB2 0.658676029898313 5.11480446318819e-07 -1.54728695593794 7.69099073313309e-06 miRanda -0.355503342954706 0.0038910869011085 NA NA NA hsa-miR-130b-3p TGFB2 1.83046548750752 5.04753914574694e-13 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.146452997905191 0.0251344950767919 NA NA NA hsa-miR-141-3p TGFB2 3.36993755486106 5.42939251147195e-32 -1.54728695593794 7.69099073313309e-06 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.398731446418857 4.7542493450425e-15 NA NA NA hsa-miR-142-3p TGFB2 3.98476449801341 1.56256182021111e-35 -1.54728695593794 7.69099073313309e-06 miRNATAP -0.187445508387807 4.91415161970629e-05 NA NA NA hsa-miR-148a-3p TGFB2 2.30885799126944 1.95226081368985e-21 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.318993015839907 3.72194712163796e-07 NA NA NA hsa-miR-148b-3p TGFB2 0.483970528590224 0.0026495409465901 -1.54728695593794 7.69099073313309e-06 MirTarget -0.597854798049066 1.54973691719479e-09 NA NA NA hsa-miR-186-5p TGFB2 0.852175445703945 6.88885738584309e-10 -1.54728695593794 7.69099073313309e-06 mirMAP -0.409008453141581 0.000403399259315524 NA NA NA hsa-miR-193b-3p TGFB2 1.10444771306846 0.000822888533401377 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.171701127106121 0.000381178774316089 NA NA NA hsa-miR-200a-3p TGFB2 3.14766878548496 1.32850889777422e-21 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.154438122204007 0.00120018739162872 25813153 Tumor suppressive microRNA 200a inhibits renal cell carcinoma development by directly targeting TGFB2; By performing quantitative real-time PCR ELISA and luciferase reporter assays transforming growth factor beta2 TGFB2 was validated as a direct target gene of miR-200a; Moreover siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression; These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2 indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC kidney renal cell cancer hsa-miR-203a-3p TGFB2 1.06866854356847 0.00389979689199624 -1.54728695593794 7.69099073313309e-06 MirTarget -0.12742735196134 0.0031970050420777 NA NA NA hsa-miR-21-5p TGFB2 4.38165933891779 1.52536633902505e-92 -1.54728695593794 7.69099073313309e-06 miRNAWalker2_validate -0.232847735640903 0.000134967329541337 NA NA NA hsa-miR-29b-3p TGFB2 3.10527711861309 3.01242507282711e-32 -1.54728695593794 7.69099073313309e-06 miRTarBase;MirTarget;miRNATAP -0.323475743722128 9.24598069519868e-09 NA NA NA hsa-miR-301a-3p TGFB2 2.70198002906399 1.56420889710984e-14 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.16074364225942 0.003487243350105 NA NA NA hsa-miR-324-5p TGFB2 1.06955541886548 5.39722006604758e-05 -1.54728695593794 7.69099073313309e-06 miRanda -0.277999824516596 3.4653275853172e-06 NA NA NA hsa-miR-330-5p TGFB2 0.168520831101569 0.336433937906706 -1.54728695593794 7.69099073313309e-06 miRanda -0.295257890261626 0.00139702498209663 NA NA NA hsa-miR-335-3p TGFB2 1.51116383169018 6.88553098788624e-13 -1.54728695593794 7.69099073313309e-06 mirMAP -0.356021240436402 1.58351764723679e-06 NA NA NA hsa-miR-375 TGFB2 0.615547997686534 0.149199273675144 -1.54728695593794 7.69099073313309e-06 miRNAWalker2_validate -0.199582093308253 8.10520720431323e-08 NA NA NA hsa-miR-454-3p TGFB2 1.49453641052169 4.46235742871434e-09 -1.54728695593794 7.69099073313309e-06 MirTarget;miRNATAP -0.278722444132023 0.000172215670429774 NA NA NA hsa-miR-589-3p TGFB2 1.34253876396688 1.84935927493927e-05 -1.54728695593794 7.69099073313309e-06 MirTarget -0.136277206270106 0.00952077915925194 NA NA NA hsa-miR-590-3p TGFB2 0.83851360565783 0.00129224433453587 -1.54728695593794 7.69099073313309e-06 mirMAP -0.246860466689251 0.000814615379526392 NA NA NA hsa-miR-590-5p TGFB2 2.07441240363458 4.95240551694843e-14 -1.54728695593794 7.69099073313309e-06 miRanda;miRNATAP -0.326100319483825 3.24920581765168e-06 NA NA NA hsa-miR-181a-5p TGFBR1 -0.375429731222937 0.0562142867129802 -0.167191366180853 0.27609922306653 mirMAP;miRNATAP -0.111893127985776 0.00187864554318442 NA NA NA hsa-miR-181b-5p TGFBR1 0.668793269169928 0.000239998092406404 -0.167191366180853 0.27609922306653 mirMAP;miRNATAP -0.106118594458465 0.00618830848725763 NA NA NA hsa-miR-186-5p TGFBR1 0.852175445703945 6.88885738584309e-10 -0.167191366180853 0.27609922306653 mirMAP -0.186046735019657 0.000240151436081305 NA NA NA hsa-miR-301a-3p TGFBR1 2.70198002906399 1.56420889710984e-14 -0.167191366180853 0.27609922306653 miRNATAP -0.127251998150772 9.77464856526446e-08 NA NA NA hsa-miR-339-5p TGFBR1 0.536997313601114 0.0488090394176611 -0.167191366180853 0.27609922306653 miRanda -0.10996653528395 1.92059453349486e-05 NA NA NA hsa-miR-454-3p TGFBR1 1.49453641052169 4.46235742871434e-09 -0.167191366180853 0.27609922306653 mirMAP;miRNATAP -0.189224937093636 4.08118068619792e-09 NA NA NA hsa-miR-500a-5p TGFBR1 0.648155655714409 0.0104657432932038 -0.167191366180853 0.27609922306653 mirMAP -0.114024018807088 6.20777757370005e-05 NA NA NA hsa-miR-590-5p TGFBR1 2.07441240363458 4.95240551694843e-14 -0.167191366180853 0.27609922306653 PITA;miRanda -0.10044599216345 0.00115082407675084 NA NA NA hsa-miR-664a-3p TGFBR1 0.443077463053857 0.0214248925850984 -0.167191366180853 0.27609922306653 mirMAP -0.121722345860296 0.000910606813958885 NA NA NA hsa-miR-96-5p TGFBR1 3.0381097138467 4.40362891630201e-24 -0.167191366180853 0.27609922306653 TargetScan;miRNATAP -0.122213570914045 1.7309565646113e-06 NA NA NA hsa-miR-107 TGFBR3 0.658676029898313 5.11480446318819e-07 -3.00237515277085 4.40834583299503e-24 MirTarget;PITA;miRanda;miRNATAP -0.270285846620861 0.0143321220786238 NA NA NA hsa-miR-15a-5p TGFBR3 1.62575353599172 1.55312121019827e-19 -3.00237515277085 4.40834583299503e-24 MirTarget;miRNATAP -0.311761657076606 5.08914930500035e-05 NA NA NA hsa-miR-16-2-3p TGFBR3 0.503964803530872 0.0263648405197492 -3.00237515277085 4.40834583299503e-24 mirMAP -0.20928613564116 0.00240552004074186 NA NA NA hsa-miR-16-5p TGFBR3 0.749619098384047 4.11649450706988e-06 -3.00237515277085 4.40834583299503e-24 MirTarget;miRNATAP -0.216664688747194 0.0143434557457065 NA NA NA hsa-miR-181b-5p TGFBR3 0.668793269169928 0.000239998092406404 -3.00237515277085 4.40834583299503e-24 mirMAP -0.162187775724044 0.0407976428509079 NA NA NA hsa-miR-182-5p TGFBR3 3.21839823004635 5.13049145201115e-39 -3.00237515277085 4.40834583299503e-24 miRNATAP -0.534083585610694 8.61423882701029e-26 NA NA NA hsa-miR-186-5p TGFBR3 0.852175445703945 6.88885738584309e-10 -3.00237515277085 4.40834583299503e-24 MirTarget -0.323350902803729 0.0018095068634619 NA NA NA hsa-miR-18a-5p TGFBR3 1.37435209536521 9.2173853686829e-06 -3.00237515277085 4.40834583299503e-24 MirTarget -0.341444481169303 2.82084364179038e-12 NA NA NA hsa-miR-193b-3p TGFBR3 1.10444771306846 0.000822888533401377 -3.00237515277085 4.40834583299503e-24 miRNAWalker2_validate;MirTarget;miRNATAP -0.229932194565447 8.29387328637064e-08 NA NA NA hsa-miR-21-5p TGFBR3 4.38165933891779 1.52536633902505e-92 -3.00237515277085 4.40834583299503e-24 miRNAWalker2_validate -0.52936321276773 3.12764271220347e-24 NA NA NA hsa-miR-29a-5p TGFBR3 1.89519956688438 1.03453349363915e-11 -3.00237515277085 4.40834583299503e-24 mirMAP -0.418871090100243 1.40022947023382e-12 NA NA NA hsa-miR-30e-5p TGFBR3 1.60414100786743 3.78951090573667e-19 -3.00237515277085 4.40834583299503e-24 mirMAP -0.159221811025132 0.0405001061313048 NA NA NA hsa-miR-335-3p TGFBR3 1.51116383169018 6.88553098788624e-13 -3.00237515277085 4.40834583299503e-24 mirMAP -0.37864161389012 9.8609617173827e-09 NA NA NA hsa-miR-339-5p TGFBR3 0.536997313601114 0.0488090394176611 -3.00237515277085 4.40834583299503e-24 miRanda -0.167582506637513 0.00149305251240295 NA NA NA hsa-miR-34a-5p TGFBR3 1.40588612517769 8.60097477768592e-12 -3.00237515277085 4.40834583299503e-24 miRNATAP -0.220917863649038 0.00126137523003733 NA NA NA hsa-miR-3607-3p TGFBR3 2.4103172144469 2.69039449048047e-08 -3.00237515277085 4.40834583299503e-24 mirMAP -0.13868711567953 1.94498344149779e-05 NA NA NA hsa-miR-424-5p TGFBR3 1.26485330287919 6.1498991028257e-06 -3.00237515277085 4.40834583299503e-24 MirTarget;miRNATAP -0.308487223690823 7.9775903952702e-10 NA NA NA hsa-miR-429 TGFBR3 2.3794516574089 1.72813419703734e-13 -3.00237515277085 4.40834583299503e-24 miRanda -0.185472108907033 7.52958455113645e-05 NA NA NA hsa-miR-450b-5p TGFBR3 1.69248953402469 1.96052058003353e-07 -3.00237515277085 4.40834583299503e-24 mirMAP -0.256214649224131 1.14421073652016e-07 NA NA NA hsa-miR-589-3p TGFBR3 1.34253876396688 1.84935927493927e-05 -3.00237515277085 4.40834583299503e-24 MirTarget -0.257060022516625 3.13989467717079e-08 NA NA NA hsa-miR-590-3p TGFBR3 0.83851360565783 0.00129224433453587 -3.00237515277085 4.40834583299503e-24 MirTarget;miRanda;mirMAP -0.415920018148628 1.5393260290838e-10 NA NA NA hsa-miR-590-5p TGFBR3 2.07441240363458 4.95240551694843e-14 -3.00237515277085 4.40834583299503e-24 miRanda -0.505798449062716 1.39039454560219e-16 NA NA NA hsa-miR-625-5p TGFBR3 1.38208523187596 6.28473801440755e-07 -3.00237515277085 4.40834583299503e-24 MirTarget -0.212491025631798 0.000206167777723719 NA NA NA hsa-miR-7-1-3p TGFBR3 2.61364240402652 1.98959237815786e-32 -3.00237515277085 4.40834583299503e-24 mirMAP -0.408156424152396 1.01954949090426e-10 NA NA NA hsa-miR-98-5p TGFBR3 1.170602085804 1.09900501665229e-08 -3.00237515277085 4.40834583299503e-24 MirTarget -0.258302459628603 0.000280407027221654 NA NA NA hsa-let-7b-5p TRIM28 -1.62016148171663 1.56547487335694e-15 0.428097605720392 0.00052518655200313 miRNAWalker2_validate -0.163356259577896 1.14414204667726e-09 NA NA NA hsa-miR-221-3p TRIM28 -0.0986794612964683 0.654454148658401 0.428097605720392 0.00052518655200313 miRNAWalker2_validate -0.116597800652396 6.08177808461284e-06 NA NA NA hsa-miR-30a-5p TRIM28 -0.924084264430689 0.000762030454634728 0.428097605720392 0.00052518655200313 miRNAWalker2_validate -0.132037200778295 7.61693324678825e-11 NA NA NA hsa-miR-590-3p WNT11 0.83851360565783 0.00129224433453587 -2.02143786067022 1.52557188447296e-07 miRanda -0.373242513422953 5.34584852988355e-06 NA NA NA hsa-miR-126-5p WNT5A 0.851637714492907 0.000391373420568359 -0.372121221213175 0.193057277928512 mirMAP -0.151248062725371 0.00563235728513554 NA NA NA hsa-miR-141-3p WNT5A 3.36993755486106 5.42939251147195e-32 -0.372121221213175 0.193057277928512 TargetScan -0.125793324099707 0.00331852934102782 NA NA NA hsa-miR-142-3p WNT5A 3.98476449801341 1.56256182021111e-35 -0.372121221213175 0.193057277928512 miRanda -0.115944016531076 0.00223771752270671 NA NA NA hsa-miR-155-5p WNT5A 0.813513839059142 0.000608282725633232 -0.372121221213175 0.193057277928512 miRNAWalker2_validate;mirMAP -0.143815735512937 0.00936896648272965 NA NA NA hsa-miR-15b-3p WNT5A 0.804736041893915 0.000400279611457186 -0.372121221213175 0.193057277928512 mirMAP -0.27043439598839 7.90998328619875e-06 NA NA NA hsa-miR-16-2-3p WNT5A 0.503964803530872 0.0263648405197492 -0.372121221213175 0.193057277928512 MirTarget;mirMAP -0.373377688750202 1.87980527171712e-09 NA NA NA hsa-miR-16-5p WNT5A 0.749619098384047 4.11649450706988e-06 -0.372121221213175 0.193057277928512 miRNAWalker2_validate -0.268804385552065 0.000862585179250393 NA NA NA hsa-miR-186-5p WNT5A 0.852175445703945 6.88885738584309e-10 -0.372121221213175 0.193057277928512 miRNAWalker2_validate;mirMAP;miRNATAP -0.417054301807237 9.65966030008268e-06 NA NA NA hsa-miR-29a-5p WNT5A 1.89519956688438 1.03453349363915e-11 -0.372121221213175 0.193057277928512 mirMAP -0.261183965471408 1.91826113480268e-06 NA NA NA hsa-miR-330-5p WNT5A 0.168520831101569 0.336433937906706 -0.372121221213175 0.193057277928512 miRanda -0.274622273940661 0.000275442864491591 NA NA NA hsa-miR-421 WNT5A 0.170525317701774 0.535277026680289 -0.372121221213175 0.193057277928512 miRanda -0.196624128752936 0.000152464264404546 NA NA NA hsa-miR-576-5p WNT5A 1.02693643167056 1.14846964470173e-06 -0.372121221213175 0.193057277928512 mirMAP -0.395707662531266 7.42053392121266e-11 NA NA NA hsa-miR-582-5p WNT5A 1.08286181406653 0.00149040450161757 -0.372121221213175 0.193057277928512 miRNATAP -0.235280095327202 1.35931910686728e-09 NA NA NA hsa-miR-590-3p WNT5A 0.83851360565783 0.00129224433453587 -0.372121221213175 0.193057277928512 miRanda;mirMAP;miRNATAP -0.160395547617788 0.00800150886159335 NA NA NA hsa-miR-7-1-3p WNT5A 2.61364240402652 1.98959237815786e-32 -0.372121221213175 0.193057277928512 mirMAP -0.239522398062042 4.22941459082507e-05 NA NA NA hsa-miR-92a-3p WNT5A -0.136362762339122 0.493412263619364 -0.372121221213175 0.193057277928512 miRNAWalker2_validate -0.355450854560077 6.47407085500391e-08 NA NA NA