miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-142-5p	DTL	-1.44575553250033	1.18797044680592e-13	3.44226759429604	9.90217851205717e-45	mirMAP	-0.20477207898611	0.0020603343331901		NA	NA	NA
hsa-miR-215-5p	DTL	-0.981544773246509	3.14452272477156e-05	3.44226759429604	9.90217851205717e-45	miRNAWalker2_validate	-0.121578119424086	0.0306944251705116	21752725;20433742	miR-215 is a tumor suppressor candidate due to the upregulation of p53 and p21 by targeting DTL; However high levels of miR-215 conferred chemoresistance due to cell cycle arrest and reduced cell proliferation by suppressing DTL; DTL was significantly over-expressed and was inversely correlated with miR-215 further suggesting an in vivo physiologic relevance of miR-215 mediated DTL suppression; Furthermore an elevated expression of a miR-215 target protein DTL was detected in colon cancer tissues whereas no expression was present in normal tissues;Taken together our results indicate that miR-215 through the suppression of DTL expression induces a decreased cell proliferation by causing G2-arrest thereby leading to an increase in chemoresistance to MTX and TDX	drug resistance;drug resistance	colon cancer;sarcoma
hsa-miR-26b-5p	DTL	-1.10804856399744	4.14176110314282e-22	3.44226759429604	9.90217851205717e-45	miRNAWalker2_validate	-0.773704529649754	1.00025145308626e-12		NA	NA	NA
hsa-miR-30a-3p	DTL	-1.52720594401486	1.3830066075708e-17	3.44226759429604	9.90217851205717e-45	MirTarget	-0.531631599483061	2.29715123192144e-14	22287560	MiR 30a 5p suppresses tumor growth in colon carcinoma by targeting DTL		colon cancer
hsa-miR-30a-5p	DTL	-0.626257932887855	0.000108198196973765	3.44226759429604	9.90217851205717e-45	miRNAWalker2_validate;miRTarBase	-0.451436588094882	2.56323699706443e-08	22287560	MiR 30a 5p suppresses tumor growth in colon carcinoma by targeting DTL; Subsequent reporter gene assays confirmed the predicted miR-30a-5p binding site in the 3'untranslated region of DTL; In conclusion our data identified miR-30a-5p as a tumor-suppressing miRNA in colon cancer cells exerting its function via modulation of DTL expression which is frequently overexpressed in colorectal cancer		colon cancer
hsa-miR-30e-3p	DTL	-1.20845647373031	3.10263633528203e-25	3.44226759429604	9.90217851205717e-45	MirTarget	-0.620342830658525	6.68292104011777e-09		NA	NA	NA
hsa-miR-376c-3p	DTL	-1.78544013329054	1.82972185127691e-10	3.44226759429604	9.90217851205717e-45	MirTarget	-0.14342892174088	0.00217811034134408		NA	NA	NA
hsa-miR-582-5p	DTL	-0.680189083316822	0.00103755166534107	3.44226759429604	9.90217851205717e-45	PITA	-0.136498228181853	0.0344236728368876		NA	NA	NA