miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-22-3p	FAM53C	0.0737573222619048	0.750445981315603	0.034744613875	0.769336237738723	MirTarget;miRNATAP	-0.134194674277261	0.007908164484383		NA	NA	NA
hsa-miR-22-3p	HDAC4	0.0737573222619048	0.750445981315603	-0.0823959226220238	0.520008023324321	miRNAWalker2_validate;miRTarBase;miRNATAP	-0.113497611525224	0.039401915711232	20842113	Furthermore histone deacetylase 4 HDAC4 known to have critical roles in cancer development was proved to be directly targeted and regulated by miR-22; Furthermore HDAC4 was upregulated in miR-22-downregulated HCC tissues suggesting that downregulation of miR-22 might participate in HCC carcinogenesis and progression through potentiation of HDAC4 expression	progression;tumorigenesis	liver cancer
hsa-miR-22-3p	ISY1	0.0737573222619048	0.750445981315603	0.0406522946755952	0.624952239701519	mirMAP	-0.100863697571664	0.00413536654122655		NA	NA	NA
hsa-miR-22-3p	JARID2	0.0737573222619048	0.750445981315603	-0.146681581208333	0.114296000313195	miRNATAP	-0.117565143389663	0.00294501797637075		NA	NA	NA
hsa-miR-22-3p	KCTD10	0.0737573222619048	0.750445981315603	-0.155083867616071	0.362988703928697	MirTarget	-0.178239044571963	0.014962214902169		NA	NA	NA
hsa-miR-22-3p	MECP2	0.0737573222619048	0.750445981315603	-0.0579009027053572	0.657335825538591	miRNATAP	-0.150758262738043	0.0067888289730938		NA	NA	NA
hsa-miR-22-3p	METTL21A	0.0737573222619048	0.750445981315603	-0.219740064151786	0.12203043712466	mirMAP	-0.130665488120934	0.0334687392036051		NA	NA	NA
hsa-miR-22-3p	MFGE8	0.0737573222619048	0.750445981315603	-0.0701734024077381	0.539328311902606	MirTarget	-0.11059868702242	0.0240308353621011		NA	NA	NA
hsa-miR-22-3p	NACC2	0.0737573222619048	0.750445981315603	-0.0822702101755952	0.561677324113132	mirMAP	-0.177481594333308	0.00326992773085057		NA	NA	NA
hsa-miR-22-3p	PLAGL2	0.0737573222619048	0.750445981315603	-0.156579587434524	0.33479641178451	miRNATAP	-0.158177634373463	0.0236310404826909		NA	NA	NA
hsa-miR-22-3p	PRPF38A	0.0737573222619048	0.750445981315603	-0.132789152967262	0.185494726991291	MirTarget	-0.126843171012311	0.00294886346160103		NA	NA	NA
hsa-miR-22-3p	SLC2A1	0.0737573222619048	0.750445981315603	-0.624716578830357	0.0468724086056969	miRNATAP	-0.302308715945737	0.0270350847680479	25304371	In this study we found that GLUT1 is a direct target of miR-22; The ectopic expression of miR-22 inhibited breast cancer cell proliferation and invasion by targeting GLUT1; A reverse correlation between the expression of miR-22 and GLUT1 was observed in breast cancer tissue samples		breast cancer
hsa-miR-22-3p	UNC119B	0.0737573222619048	0.750445981315603	-0.163698441830357	0.344532871332441	MirTarget	-0.155542590969994	0.0373976602019562		NA	NA	NA
hsa-miR-22-3p	WDR82	0.0737573222619048	0.750445981315603	-0.000793915610119031	0.993216536377644	MirTarget	-0.114601369683416	0.00375565573912198		NA	NA	NA