miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-223-3p	ADCY1	-0.219863334942404	0.708457258631868	-0.136166970563614	0.729350109785873	mirMAP	-0.143179102009228	0.0226632142792077		NA	NA	NA
hsa-miR-223-3p	CBX5	-0.219863334942404	0.708457258631868	0.134684967853583	0.841080898804454	MirTarget	-0.101776472965006	0.000165015353088333		NA	NA	NA
hsa-miR-223-3p	CCKBR	-0.219863334942404	0.708457258631868	-0.111044071833698	0.861391313293329	MirTarget	-0.226644994111278	0.0313564333742983		NA	NA	NA
hsa-miR-223-3p	DENND5B	-0.219863334942404	0.708457258631868	-0.0839460825988723	0.824916774121399	MirTarget	-0.104546111943232	0.00661454788355067		NA	NA	NA
hsa-miR-223-3p	IGF1R	-0.219863334942404	0.708457258631868	0.181844503809824	0.77996203041897	miRNAWalker2_validate;miRTarBase;MirTarget	-0.16141726837523	0.000381580390352609		NA	NA	NA
hsa-miR-223-3p	KBTBD6	-0.219863334942404	0.708457258631868	0.152529043567843	0.683829276409468	MirTarget	-0.145413423311255	7.81180366061669e-10		NA	NA	NA
hsa-miR-223-3p	KLF12	-0.219863334942404	0.708457258631868	-0.107461049696606	0.79612046968107	mirMAP	-0.105719187256552	0.00248565871122839		NA	NA	NA
hsa-miR-223-3p	KSR2	-0.219863334942404	0.708457258631868	0.014552829135464	0.969087101509327	mirMAP	-0.133617990780652	0.0113730710405893		NA	NA	NA
hsa-miR-223-3p	MAPK4	-0.219863334942404	0.708457258631868	0.396198796411467	0.481727779447295	mirMAP	-0.281912933676798	0.0022786302045033		NA	NA	NA
hsa-miR-223-3p	PTPRT	-0.219863334942404	0.708457258631868	1.26309147338408	0.131785433872241	mirMAP	-0.312595370170793	0.026535958510966		NA	NA	NA
hsa-miR-223-3p	RAB11FIP4	-0.219863334942404	0.708457258631868	-0.222642393707723	0.710864407516278	mirMAP	-0.117714957057048	0.016447278008862		NA	NA	NA
hsa-miR-223-3p	SDK2	-0.219863334942404	0.708457258631868	0.166710637782467	0.765669976482083	mirMAP	-0.235543217796054	0.00512198091051859		NA	NA	NA
hsa-miR-223-3p	SMARCD1	-0.219863334942404	0.708457258631868	0.00465253839749646	0.99372377947093	miRNAWalker2_validate;MirTarget	-0.116395262285959	9.80401938312476e-08		NA	NA	NA
hsa-miR-223-3p	STMN1	-0.219863334942404	0.708457258631868	-0.0949988620441671	0.890421111904625	miRNAWalker2_validate;miRTarBase	-0.121355096891945	0.000615142843198793	27577078;18555017;22470493	miR 223 increases gallbladder cancer cell sensitivity to docetaxel by downregulating STMN1; We determined that STMN1 was negatively correlated with and regulated by miR-223 in GBC miR-223 increased GBC sensitivity to docetaxel in vitro and in vivo and the induced sensitivity to docetaxel was suppressed by the restoration of STMN1 expression; These findings indicated that miR-223 might serve as an onco-suppressor that enhances susceptibility to docetaxel by downregulating STMN1 in GBC highlighting its promising therapeutic value;A strong inverse relationship between STMN1 mRNA and miR-223 expressions was shown P = .006; A substantial reduction in STMN1 protein was further demonstrated upon restoration of miR-223 expression in HCC cell lines; We further showed that miR-223 readily could suppress the luciferase activity in reporter construct containing the STMN1 3' untranslated region P = .02;We also explored the regulation of STMN1 expression by microRNA-223; We finally confirmed that STMN1 is a putative downstream target of miR-223 in gastric cancer	;;	bladder cancer;liver cancer;gastric cancer
hsa-miR-223-3p	ZNF286A	-0.219863334942404	0.708457258631868	0.0784960209341476	0.828626022797843	mirMAP	-0.115765940777687	1.77608962856038e-05		NA	NA	NA
hsa-miR-223-3p	ZNF286B	-0.219863334942404	0.708457258631868	0.191251168159748	0.469627408264016	mirMAP	-0.12998530903547	0.00251744625902647		NA	NA	NA
hsa-miR-223-3p	ZNF772	-0.219863334942404	0.708457258631868	-0.186151174166256	0.641668520513098	MirTarget	-0.104439258738604	0.00912644252522603		NA	NA	NA