miRNA	gene	miRNA_log2FC	miRNA_pvalue	gene_log2FC	gene_pvalue	interactions	correlation_beta	correlation_pvalue	PMID	evidence	outcome	cancer
hsa-miR-195-5p	BCL2L11	-1.07154705036962	4.16544134775761e-08	0.413923585963092	0.000434820349815219	miRNAWalker2_validate	-0.134807821070255	0.000183366667864393		NA	NA	NA
hsa-miR-195-5p	CAND1	-1.07154705036962	4.16544134775761e-08	0.404447093370241	0.000129508898109157	miRNAWalker2_validate	-0.235601237423065	3.66753860690047e-14		NA	NA	NA
hsa-miR-195-5p	CCND1	-1.07154705036962	4.16544134775761e-08	0.720140419027159	0.000259727836476946	miRNAWalker2_validate	-0.270917365501396	6.99604795762646e-06	21350001;26631043;25823925	Raf-1 and Ccnd1 were identified as novel direct targets of miR-195 and miR-497 miR-195/497 expression levels in clinical specimens were found to be correlated inversely with malignancy of breast cancer;MiR 195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1; The present study was to evaluate the level of miR-195 and cyclin D1 in CC tissues and cells; We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa; Furthermore the expression of miR-195 was inversely proportional to that of cyclin D1 mRNA or protein p = 0.013 p = 0.015 respectively; However the inhibitor of miR-195 promoted the expression of cyclin D1 and cell proliferation; In conclusion our data suggest that miR-195 may have the potential role in treatment of CC patients as well as miR-195 is a novel regulator of invasiveness and tumorigenicity in CC cells by targeting cyclin D1;MicroRNA profiling identifies MiR 195 suppresses osteosarcoma cell metastasis by targeting CCND1; Meanwhile CCND1 was identified as the target gene of miR-195 and further studied; More importantly using real-time PCR we evaluated the expression of miR-195 and CCND1 in osteosarcoma samples from 107 frozen biopsy tissues and 99 formalin- or paraformalin-fixed paraffin-embedded FFPE tissues; Results indicated lowly expressed miR-195 or highly CCND1 correlated with positive overall survival and their expression inversely related to each other; In summary our study suggests miR-195 functions as a tumor metastasis suppressor gene by down-regulating CCND1 and can be used as a potential target in the treatment of osteosarcoma	;;metastasis;poor survival	breast cancer;cervical and endocervical cancer;sarcoma
hsa-miR-195-5p	CCNE1	-1.07154705036962	4.16544134775761e-08	1.63902722877652	2.5095106440044e-08	miRNAWalker2_validate	-0.508445516091264	1.96888625792722e-08	24402230	Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively		breast cancer
hsa-miR-195-5p	CDK6	-1.07154705036962	4.16544134775761e-08	0.990643124320291	1.17862667832619e-06	miRNAWalker2_validate	-0.290091435905514	3.96478737812371e-06	23333942	Expression of cyclin-dependent kinase 6 and vascular endothelial growth factor was down-regulated by exogenous miR-195 and miR-378 respectively		gastric cancer
hsa-miR-195-5p	CHUK	-1.07154705036962	4.16544134775761e-08	0.260508655820102	0.00541846716349918	miRNAWalker2_validate	-0.209408932879662	1.77454617069446e-14		NA	NA	NA
hsa-miR-195-5p	COPB1	-1.07154705036962	4.16544134775761e-08	0.189493260480481	0.0226598567840602	miRNAWalker2_validate	-0.159026095448629	8.64434912662813e-11		NA	NA	NA
hsa-miR-195-5p	E2F3	-1.07154705036962	4.16544134775761e-08	1.28918854042277	1.74177583223201e-27	miRNAWalker2_validate	-0.317627344832083	6.58598738402716e-17	22217655	We identified E2F3 and CCND3 as functional downstream targets of miR-195 in glioblastoma cells		glioblastoma
hsa-miR-16-5p	LAMC1	0.468459442059375	0.02635007201346	0.370285667657678	0.0366283240859651	miRNAWalker2_validate	-0.34568030515619	2.92954987151097e-12		NA	NA	NA
hsa-miR-29c-3p	LAMC1	-1.34143813218298	2.77493790306384e-12	0.370285667657678	0.0366283240859651	miRNAWalker2_validate	-0.255427761607858	1.89773257657361e-06		NA	NA	NA
hsa-miR-92a-3p	LAMC1	1.06124545165614	6.51550014372282e-08	0.370285667657678	0.0366283240859651	miRNAWalker2_validate	-0.220119230160509	4.06172849280034e-05		NA	NA	NA
hsa-miR-98-5p	LAMC1	0.72508924193932	6.07191196761022e-10	0.370285667657678	0.0366283240859651	miRNAWalker2_validate	-0.188480153680342	0.0407044980467923		NA	NA	NA
hsa-miR-195-5p	LSM11	-1.07154705036962	4.16544134775761e-08	0.273916573216644	0.0292937409084412	miRNAWalker2_validate	-0.191281415493267	4.25811958297105e-07		NA	NA	NA
hsa-miR-195-5p	NOLC1	-1.07154705036962	4.16544134775761e-08	0.827281816095402	3.03296920517241e-12	miRNAWalker2_validate	-0.296839078408795	9.27633085658343e-17		NA	NA	NA
hsa-miR-195-5p	SPTBN1	-1.07154705036962	4.16544134775761e-08	0.561275562374965	5.96130333653201e-06	miRNAWalker2_validate	-0.204068566972056	6.37000910355698e-08		NA	NA	NA
hsa-miR-195-5p	TAB3	-1.07154705036962	4.16544134775761e-08	-0.137642609319934	0.200368384324507	miRNAWalker2_validate	-0.127526153235332	8.76377639382731e-05	23487264	Genome wide screening reveals that miR 195 targets the TNF α/NF κB pathway by down regulating IκB kinase alpha and TAB3 in hepatocellular carcinoma; Additionally miR-195 may exert its tumor suppressive function by decreasing the expression of multiple NF-κB downstream effectors by way of the direct targeting of IKKα and TAB3		liver cancer
hsa-miR-195-5p	TBCCD1	-1.07154705036962	4.16544134775761e-08	0.314584516059425	0.000121155725844881	miRNAWalker2_validate	-0.151718018065482	5.18265323784501e-10		NA	NA	NA
hsa-miR-195-5p	TMC6	-1.07154705036962	4.16544134775761e-08	1.020416407279	9.1786722865417e-11	miRNAWalker2_validate	-0.158504425505592	0.00148372624073434		NA	NA	NA
hsa-miR-195-5p	VEGFA	-1.07154705036962	4.16544134775761e-08	0.628775505110226	0.000620913144913639	miRNAWalker2_validate	-0.293488826214044	1.3561926096363e-07	27574422;23468064;26823724	In this study we used a new cationic peptide disulfide cross-linked stearylated polyarginine peptide modified with histidine H3R5 as a reducible vector cell penetrating peptide-modified aptamer ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe miRNA-195 miR195 as a powerful gene drug to inhibit VEGF and fasudil to suppress vasculogenic mimicry by blocking ROCK2 all of which were simultaneously encapsulated in the same nanoparticles;Furthermore we revealed that miR-195 down-regulation resulted in enhanced VEGF levels in the tumor microenvironment which subsequently activated VEGF receptor 2 signaling in endothelial cells and thereby promoted angiogenesis;MiR 195 is a key negative regulator of hepatocellular carcinoma metastasis by targeting FGF2 and VEGFA; Luciferase reporter and ELISA assay prove that hematogenous metastasis related genes including FGF2 and VEGFA are the target genes of miR-195; Taken together our results suggest that miR-195 a tumor suppressor miRNA contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA providing key implications of miR-195 for the therapeutic intervention of HCC	;;metastasis	liver cancer;liver cancer;liver cancer
hsa-miR-195-5p	WEE1	-1.07154705036962	4.16544134775761e-08	-0.0579007535730272	0.673440236749829	miRNAWalker2_validate	-0.178028991259314	1.77025396139394e-05	22847610	Regulation of cell cycle checkpoint kinase WEE1 by miR 195 in malignant melanoma; Moreover there was an inverse correlation between the expression of WEE1 and WEE1-targeting microRNA miR-195; Further analyses showed that transfection of melanoma cell lines with miR-195 indeed reduced WEE1 mRNA and protein expression in these cells; Reporter gene analysis confirmed direct targeting of the WEE1 3' untranslated region 3'UTR by miR-195; Overexpression of miR-195 in SK-Mel-28 melanoma cells was accompanied by WEE1 reduction and significantly reduced stress-induced G2-M cell cycle arrest which could be restored by stable overexpression of WEE1; Moreover miR-195 overexpression and WEE1 knockdown respectively increased melanoma cell proliferation; Taken together the present study shows that WEE1 expression in malignant melanoma is directly regulated by miR-195 miR-195-mediated downregulation of WEE1 in metastatic lesions may help to overcome cell cycle arrest under stress conditions in the local tissue microenvironment to allow unrestricted growth of tumour cells	malignant trasformation	melanoma
hsa-miR-195-5p	ZNF280C	-1.07154705036962	4.16544134775761e-08	0.906053725885801	1.25372741934245e-11	miRNAWalker2_validate	-0.379684543694264	4.93004853221114e-22		NA	NA	NA