miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-181b-5p ABCA5 0.488256489401108 0.00105321129419701 -0.135688344893514 0.307906525890114 mirMAP -0.263200077061798 6.19679810308192e-10 NA NA NA hsa-miR-181b-5p ABHD13 0.488256489401108 0.00105321129419701 -0.675509398353543 1.01147666568484e-14 MirTarget -0.107355672286902 0.00024307849858895 NA NA NA hsa-miR-181b-5p ABHD15 0.488256489401108 0.00105321129419701 -1.30485636745916 1.43347474031291e-12 mirMAP -0.437228081342153 3.82119743580348e-13 NA NA NA hsa-miR-181b-5p ABTB2 0.488256489401108 0.00105321129419701 -0.433245274232974 0.00309618873065253 MirTarget;miRNATAP -0.335782834467882 6.43366504390091e-13 NA NA NA hsa-miR-181b-5p ACAD8 0.488256489401108 0.00105321129419701 -0.524681533173251 9.68967331022413e-09 MirTarget -0.145164990680537 1.30987425524445e-06 NA NA NA hsa-miR-181b-5p ACSL1 0.488256489401108 0.00105321129419701 -2.33415071716027 1.71568734924942e-22 MirTarget -0.687895701481087 3.7949325394145e-18 NA NA NA hsa-miR-181b-5p ACSL6 0.488256489401108 0.00105321129419701 0.391527588368073 0.264580316303862 miRNATAP -0.746850334596502 2.61440384460246e-11 NA NA NA hsa-miR-181b-5p ACSS3 0.488256489401108 0.00105321129419701 -1.23440155322414 0.00018681401186901 MirTarget -1.00354902484031 2.36850449271824e-22 NA NA NA hsa-miR-181b-5p ACVR1C 0.488256489401108 0.00105321129419701 -2.19871896765337 7.84657232630462e-19 miRNATAP -0.665132657201591 4.28032049160444e-16 NA NA NA hsa-miR-181b-5p ADCY1 0.488256489401108 0.00105321129419701 -2.70370487380383 7.2704291027202e-13 miRNATAP -0.494927599091523 8.65582994023564e-05 NA NA NA hsa-miR-181b-5p ADCY9 0.488256489401108 0.00105321129419701 -0.112772641173273 0.305182803085656 miRNATAP -0.141141664717883 7.37217908544658e-05 24269684 miR 181b promotes cell proliferation and reduces apoptosis by repressing the expression of adenylyl cyclase 9 AC9 in cervical cancer cells; Phenotypic experiments indicated that miR-181b and AC9 exerted opposite effects on cell proliferation and apoptosis cervical and endocervical cancer hsa-miR-181b-5p ADM 0.488256489401108 0.00105321129419701 -1.25701281969115 8.72037958641707e-12 MirTarget;miRNATAP -0.183092555044565 0.00296714842857999 NA NA NA hsa-miR-181b-5p AFF4 0.488256489401108 0.00105321129419701 -0.640374726233926 1.97427244265237e-11 mirMAP;miRNATAP -0.143174481452508 5.89379807066163e-06 NA NA NA hsa-miR-181b-5p AFG3L2 0.488256489401108 0.00105321129419701 -0.28998014178049 0.00030377062530172 MirTarget;miRNATAP -0.142360062365536 3.79557820002773e-08 NA NA NA hsa-miR-181b-5p AGFG2 0.488256489401108 0.00105321129419701 -0.0193527168337146 0.870605356857287 mirMAP -0.185383995429184 1.28072102143324e-06 NA NA NA hsa-miR-181b-5p AGGF1 0.488256489401108 0.00105321129419701 0.137594763085771 0.0302630023319463 mirMAP -0.115950572164104 1.06533517125863e-08 NA NA NA hsa-miR-181b-5p AGPAT3 0.488256489401108 0.00105321129419701 -0.179576731247055 0.0550734832332654 MirTarget -0.114435707539793 0.000162584766447576 NA NA NA hsa-miR-181b-5p AKR1C1 0.488256489401108 0.00105321129419701 -0.121013255853734 0.654126652200671 mirMAP -0.524319440121615 1.37226137432425e-09 NA NA NA hsa-miR-21-5p AKT2 1.51084295924322 1.54551622173259e-34 -0.343608685894869 1.25471482871759e-05 miRNAWalker2_validate -0.246625533117166 4.43585626011661e-19 NA NA NA hsa-miR-330-5p AKT2 0.442231058604099 0.0053308560843808 -0.343608685894869 1.25471482871759e-05 miRanda -0.10429759179516 1.49133299948889e-05 NA NA NA hsa-miR-342-3p AKT2 -0.319677314984262 0.0449813878317147 -0.343608685894869 1.25471482871759e-05 mirMAP -0.124944719707983 1.72780303356483e-07 NA NA NA hsa-miR-106b-5p AKT3 0.648901865047099 8.24870862047885e-09 -0.658799312069129 0.000471762262250455 miRNATAP -0.257549207275002 0.00147770551388523 NA NA NA hsa-miR-107 AKT3 0.241662461253461 0.0170788899505389 -0.658799312069129 0.000471762262250455 PITA;miRanda -0.603074134996255 1.95007791380395e-11 NA NA NA hsa-miR-122-5p AKT3 -1.23907441373955 4.42181244888642e-06 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase -0.282597613468804 3.13172096832783e-18 24244539 miR 122 regulates tumorigenesis in hepatocellular carcinoma by targeting AKT3; Here we identify AKT3 as a novel and direct target of miR-122; Restoration of miR-122 expression in HCC cell lines decreases AKT3 levels inhibits cell migration and proliferation and induces apoptosis; These anti-tumor phenotypes can be rescued by reconstitution of AKT3 expression indicating the essential role of AKT3 in miR-122 mediated HCC transformation; Our data strongly suggest that miR-122 is a tumor suppressor that targets AKT3 to regulate tumorigenesis in HCCs and a potential therapeutic candidate for liver cancer tumorigenesis;cell migration liver cancer hsa-miR-146b-5p AKT3 0.419719546795449 0.0457375823220155 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate -0.159678144375669 0.000263366078999813 NA NA NA hsa-miR-15a-5p AKT3 0.349521211668244 0.000770735998804736 -0.658799312069129 0.000471762262250455 miRNAWalker2_validate;miRTarBase;miRNATAP -0.265425410812535 0.00291348888530609 NA NA NA hsa-miR-17-3p AKT3 0.410352776142368 0.00422200500748636 -0.658799312069129 0.000471762262250455 miRNATAP -0.350392140268267 3.46133659001702e-08 NA NA NA hsa-miR-17-5p AKT3 0.698861147045461 2.43854106455398e-05 -0.658799312069129 0.000471762262250455 TargetScan;miRNATAP -0.290786763807918 1.04942988053081e-07 NA NA NA hsa-miR-20a-5p AKT3 0.854326758727003 5.04256669663285e-07 -0.658799312069129 0.000471762262250455 miRNATAP -0.294574079686222 2.60181650003526e-08 NA NA NA hsa-miR-32-3p AKT3 0.219109440121582 0.207217051619543 -0.658799312069129 0.000471762262250455 mirMAP -0.225932925933496 3.62088303609835e-05 NA NA NA hsa-miR-33a-3p AKT3 -0.683025859637737 1.01106097756419e-05 -0.658799312069129 0.000471762262250455 mirMAP -0.229716914608906 0.000100074832030455 NA NA NA hsa-miR-362-3p AKT3 0.814007335895913 2.00108618836568e-09 -0.658799312069129 0.000471762262250455 miRanda -0.223301194831745 0.00083465748836002 NA NA NA hsa-miR-362-5p AKT3 0.717921690799312 1.68392734504524e-05 -0.658799312069129 0.000471762262250455 PITA;TargetScan;miRNATAP -0.147261080417749 0.00734435768679755 NA NA NA hsa-miR-374a-5p AKT3 0.016390363747302 0.869784217438621 -0.658799312069129 0.000471762262250455 mirMAP -0.277843537840681 0.00293899073092604 NA NA NA hsa-miR-421 AKT3 0.941856334694081 6.12167297054077e-08 -0.658799312069129 0.000471762262250455 miRanda;mirMAP -0.133809007743249 0.0109099775591746 NA NA NA hsa-miR-501-3p AKT3 0.999540908940094 2.77358485581974e-11 -0.658799312069129 0.000471762262250455 miRNATAP -0.119128898090902 0.0482272940757398 NA NA NA hsa-miR-502-3p AKT3 0.659598854007546 3.01316453996423e-08 -0.658799312069129 0.000471762262250455 miRNATAP -0.256952206617794 0.000795069967308112 NA NA NA hsa-miR-616-5p AKT3 0.150569904638223 0.402836556304524 -0.658799312069129 0.000471762262250455 mirMAP -0.200000357827185 9.73725948226915e-05 NA NA NA hsa-miR-93-5p AKT3 1.39518349670953 2.84167728726712e-25 -0.658799312069129 0.000471762262250455 miRNATAP -0.283992832133781 1.04884093066001e-05 NA NA NA hsa-miR-181b-5p ANKRD50 0.488256489401108 0.00105321129419701 -0.252776516079819 0.0443267488846649 MirTarget;miRNATAP -0.111613112295002 0.00648394189363301 NA NA NA hsa-miR-181b-5p AP1G1 0.488256489401108 0.00105321129419701 -0.476980051128284 2.74183835894147e-09 miRNATAP -0.136421575290936 2.0456925590208e-07 NA NA NA hsa-miR-181b-5p API5 0.488256489401108 0.00105321129419701 -0.322976149788153 2.1337750512996e-08 MirTarget -0.1603804940941 1.13508903128198e-18 NA NA NA hsa-miR-181b-5p AR 0.488256489401108 0.00105321129419701 -2.65514434874701 6.79656050811819e-11 miRNATAP -1.29824857260422 6.54962591623091e-24 NA NA NA hsa-miR-181b-5p ARFGEF2 0.488256489401108 0.00105321129419701 0.0424551780056248 0.707114343548082 MirTarget;miRNATAP -0.105659517208244 0.00401934990541995 NA NA NA hsa-miR-181b-5p ARHGAP32 0.488256489401108 0.00105321129419701 -0.199023023372693 0.099211320915758 mirMAP -0.145074366816109 0.000213938697578004 NA NA NA hsa-miR-181b-5p ARHGAP5 0.488256489401108 0.00105321129419701 -0.390501975399923 8.01729872271933e-05 mirMAP -0.156486821983914 1.13906378427161e-06 NA NA NA hsa-miR-181b-5p ARIH1 0.488256489401108 0.00105321129419701 -0.131545607366657 0.0699251677277551 MirTarget;mirMAP -0.125581048645029 6.59565969581704e-08 NA NA NA hsa-miR-181b-5p ARRDC3 0.488256489401108 0.00105321129419701 -0.701093957153481 3.22762889898878e-06 MirTarget;mirMAP;miRNATAP -0.19578924636293 7.46009942548185e-05 NA NA NA hsa-miR-181b-5p ASB13 0.488256489401108 0.00105321129419701 -0.761648880670108 5.02646663365169e-08 miRNAWalker2_validate -0.382795548186767 8.09796222428554e-18 NA NA NA hsa-miR-181b-5p ASPA 0.488256489401108 0.00105321129419701 -2.87708424623409 2.78732403857851e-24 mirMAP -0.463818940856489 1.78856178519175e-06 NA NA NA hsa-miR-181b-5p ATE1 0.488256489401108 0.00105321129419701 -0.60221529485003 0.000898690867899849 mirMAP -0.147580490607351 0.013161070971975 NA NA NA hsa-miR-181b-5p ATP11C 0.488256489401108 0.00105321129419701 -1.59600836056671 1.48402272878339e-18 MirTarget;miRNATAP -0.558459883888642 2.83012648582225e-21 NA NA NA hsa-miR-181b-5p ATXN1 0.488256489401108 0.00105321129419701 -0.14706644380352 0.164122106364193 miRNATAP -0.107973197961354 0.001670203706715 NA NA NA hsa-miR-181b-5p ATXN7 0.488256489401108 0.00105321129419701 -0.468011155586228 2.62773540153588e-07 MirTarget -0.112981735252082 0.000154865012205089 NA NA NA hsa-miR-181b-5p BCL6 0.488256489401108 0.00105321129419701 -0.381728718096561 0.00304721869179574 miRNATAP -0.19439898428624 3.29254065682167e-06 NA NA NA hsa-miR-181b-5p BHLHE40 0.488256489401108 0.00105321129419701 -1.42834263281938 2.56737972441221e-18 MirTarget;miRNATAP -0.133375202341344 0.0168411811221064 NA NA NA hsa-miR-181b-5p BRWD1 0.488256489401108 0.00105321129419701 -0.472319203635839 2.18876455365102e-07 MirTarget -0.154688424650566 1.94268680460216e-07 NA NA NA hsa-miR-181b-5p C16orf87 0.488256489401108 0.00105321129419701 -0.852328170796381 9.88960275881957e-13 miRNATAP -0.226491575098053 9.52186233186709e-09 NA NA NA hsa-miR-181b-5p C17orf51 0.488256489401108 0.00105321129419701 -0.666308125870991 0.001643343913341 mirMAP -0.150440087660372 0.0304162372972828 NA NA NA hsa-miR-181b-5p C2orf69 0.488256489401108 0.00105321129419701 -0.190645957879418 0.0407940707859741 miRNATAP -0.24937263137335 1.30663265356443e-17 NA NA NA hsa-miR-181b-5p C5orf51 0.488256489401108 0.00105321129419701 0.245646842072128 0.00284809732816773 mirMAP -0.114139238551824 1.87700233679776e-05 NA NA NA hsa-miR-181b-5p CA13 0.488256489401108 0.00105321129419701 -1.25765459479166 8.96894103763698e-10 mirMAP -0.287227471449388 2.38466126975356e-05 NA NA NA hsa-miR-15a-5p CAB39 0.349521211668244 0.000770735998804736 -0.152804524606349 0.00962811714746276 miRNATAP -0.108425253583809 7.85731490720904e-05 NA NA NA hsa-miR-16-1-3p CAB39 0.392360028038559 0.00112481918108198 -0.152804524606349 0.00962811714746276 MirTarget -0.117268659952457 5.98270638213691e-07 NA NA NA hsa-miR-193a-3p CAB39 -0.117675551589896 0.309391958208578 -0.152804524606349 0.00962811714746276 MirTarget;miRanda -0.123942945247746 4.68902843877997e-07 NA NA NA hsa-miR-192-3p CAB39L -0.6401165114007 0.000266272092403814 -0.504869726858055 1.1927547950473e-05 mirMAP -0.122781017802891 0.0001220181908619 NA NA NA hsa-miR-192-5p CAB39L -0.50188499512787 0.00344713341196035 -0.504869726858055 1.1927547950473e-05 miRNAWalker2_validate -0.168189458314805 2.40399921852626e-07 NA NA NA hsa-miR-361-5p CAB39L 0.233202959858696 0.00961572812255327 -0.504869726858055 1.1927547950473e-05 MirTarget;miRanda -0.195565910720272 0.00208448717872423 NA NA NA hsa-miR-362-3p CAB39L 0.814007335895913 2.00108618836568e-09 -0.504869726858055 1.1927547950473e-05 miRanda -0.153089959329449 0.000183470156830685 NA NA NA hsa-miR-374a-3p CAB39L -0.207171354826929 0.0623494608399903 -0.504869726858055 1.1927547950473e-05 MirTarget -0.116409883482865 0.0235530963021377 NA NA NA hsa-miR-590-3p CAB39L -0.473167498047808 1.76652934637227e-05 -0.504869726858055 1.1927547950473e-05 miRanda -0.103141246174533 0.0448666468840738 NA NA NA hsa-miR-590-5p CAB39L -0.103355559980404 0.310027295317092 -0.504869726858055 1.1927547950473e-05 miRanda -0.137271393364833 0.014772112957972 NA NA NA hsa-miR-618 CAB39L 0.13539895350352 0.517145913114103 -0.504869726858055 1.1927547950473e-05 mirMAP -0.10129028583161 0.000298566594868403 NA NA NA hsa-miR-181b-5p CABLES1 0.488256489401108 0.00105321129419701 -0.23961548519258 0.15759844149133 mirMAP -0.132641625745201 0.0165615180037337 NA NA NA hsa-miR-181b-5p CASK 0.488256489401108 0.00105321129419701 0.42777049580758 0.000114042576949703 mirMAP -0.109001854494032 0.00270234160607011 NA NA NA hsa-miR-181b-5p CAT 0.488256489401108 0.00105321129419701 -1.65049060277008 8.91987155536677e-23 miRNAWalker2_validate -0.498596106276817 2.48505880380441e-19 NA NA NA hsa-miR-181b-5p CBX7 0.488256489401108 0.00105321129419701 -0.0772822295902893 0.529369946505877 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.297526454109628 1.70841481752323e-14 NA NA NA hsa-miR-181b-5p CDC42BPA 0.488256489401108 0.00105321129419701 0.0504128376522637 0.704432077177647 MirTarget;miRNATAP -0.218747219015265 3.15924555392319e-07 NA NA NA hsa-miR-181b-5p CDC5L 0.488256489401108 0.00105321129419701 0.176206413769978 0.029009075721495 mirMAP -0.107017818513578 4.12480864395034e-05 NA NA NA hsa-miR-181b-5p CEP120 0.488256489401108 0.00105321129419701 -0.38529251765269 1.61409004225275e-05 MirTarget -0.107221869943166 0.000243460725969443 NA NA NA hsa-miR-181b-5p CHD9 0.488256489401108 0.00105321129419701 -0.511590175184198 2.71332522550186e-05 miRNATAP -0.154636621343966 0.000106459019244057 NA NA NA hsa-miR-181b-5p CLCN5 0.488256489401108 0.00105321129419701 -0.778462528596492 1.09010470162582e-08 mirMAP -0.145186839362961 0.00129240986340382 NA NA NA hsa-miR-181b-5p CLIP1 0.488256489401108 0.00105321129419701 -0.277457644294426 0.00917645327427696 MirTarget;miRNATAP -0.149344504492455 1.5223432806567e-05 NA NA NA hsa-miR-181b-5p CLOCK 0.488256489401108 0.00105321129419701 -0.52744295488734 0.00745405676073919 mirMAP -0.13136442574215 0.0421021972963017 NA NA NA hsa-miR-181b-5p CNKSR2 0.488256489401108 0.00105321129419701 -0.547020289576205 0.157714486315915 MirTarget;miRNATAP -0.691635497149149 2.88603014926427e-08 NA NA NA hsa-miR-181b-5p CNNM2 0.488256489401108 0.00105321129419701 0.0459983088368134 0.648766534465195 miRNATAP -0.179090615638109 3.16048440845905e-08 NA NA NA hsa-miR-181b-5p CNST 0.488256489401108 0.00105321129419701 -0.204837317225117 0.03828693885939 mirMAP -0.178641505069534 1.83051666229557e-08 NA NA NA hsa-miR-181b-5p CNTNAP3 0.488256489401108 0.00105321129419701 0.106558723996186 0.742851881030026 MirTarget -0.340083445890052 0.00129626018763495 NA NA NA hsa-miR-181b-5p COBL 0.488256489401108 0.00105321129419701 -0.625889423404631 0.000231830653158842 mirMAP -0.168685018771801 0.00248953182296669 NA NA NA hsa-miR-181b-5p CPEB4 0.488256489401108 0.00105321129419701 -1.06097838176943 9.01316045116939e-14 miRNATAP -0.293627483456073 4.15505130809149e-10 NA NA NA hsa-miR-181b-5p CPOX 0.488256489401108 0.00105321129419701 -0.645483352349819 2.25342441240631e-12 MirTarget -0.16613920486179 4.38128953909762e-08 NA NA NA hsa-miR-181b-5p CREBL2 0.488256489401108 0.00105321129419701 -0.86271516459951 5.41073501751202e-18 MirTarget -0.275659614826832 3.03458501290093e-17 NA NA NA hsa-miR-181b-5p CSNK1G3 0.488256489401108 0.00105321129419701 -0.368768249275336 6.89562099916135e-07 mirMAP;miRNATAP -0.116637274657514 1.4293217699323e-06 NA NA NA hsa-miR-181b-5p CXADR 0.488256489401108 0.00105321129419701 -0.234780594951993 0.196678109410481 miRNATAP -0.173380879235352 0.00343841362321261 NA NA NA hsa-miR-181b-5p CYP4F3 0.488256489401108 0.00105321129419701 -1.55307662086169 1.07679103282901e-07 mirMAP -0.808038178475637 3.98523550732589e-18 NA NA NA hsa-miR-181b-5p DAAM1 0.488256489401108 0.00105321129419701 -0.820319075229238 3.16122030911227e-05 mirMAP -0.244543574167562 0.000154525603721181 NA NA NA hsa-miR-30d-5p DDIT4 0.718283816348023 2.47422074061352e-08 0.228443977506799 0.236844454905723 MirTarget;miRNATAP -0.20537756673444 0.00438989200660324 NA NA NA hsa-miR-32-5p DDIT4 0.0806126674664016 0.548984992497432 0.228443977506799 0.236844454905723 miRNATAP -0.199880895095326 0.00445876889151134 NA NA NA hsa-miR-618 DDIT4 0.13539895350352 0.517145913114103 0.228443977506799 0.236844454905723 mirMAP -0.103348311950453 0.0269914503772347 NA NA NA hsa-miR-92a-3p DDIT4 0.212391012518195 0.134292268089997 0.228443977506799 0.236844454905723 miRNATAP -0.182713424395714 0.00604393810305066 NA NA NA hsa-miR-181b-5p DDX60L 0.488256489401108 0.00105321129419701 -0.811104267116272 3.25564263019604e-07 MirTarget -0.169427467105289 0.00123147545717295 NA NA NA hsa-miR-181b-5p DENND4C 0.488256489401108 0.00105321129419701 -0.449333876796266 4.55066587024558e-06 MirTarget -0.117986711712167 0.000240486972135867 NA NA NA hsa-miR-181b-5p DENND5B 0.488256489401108 0.00105321129419701 -0.618139309020725 4.9388184165447e-08 MirTarget;mirMAP -0.253407974729127 4.59295916203923e-12 NA NA NA hsa-miR-181b-5p DERL1 0.488256489401108 0.00105321129419701 0.117647235923305 0.20253397831506 MirTarget;miRNATAP -0.142372595425966 1.67898859100791e-06 NA NA NA hsa-miR-181b-5p DIAPH1 0.488256489401108 0.00105321129419701 -0.401899970495966 2.22782677309071e-05 mirMAP -0.2822980294356 1.59048713253967e-21 NA NA NA hsa-miR-181b-5p DIP2C 0.488256489401108 0.00105321129419701 -0.777858675870751 4.97084735087691e-05 MirTarget;miRNATAP -0.276723694674535 9.95957435216485e-06 NA NA NA hsa-miR-181b-5p DIXDC1 0.488256489401108 0.00105321129419701 -1.03337855682211 1.80344543578202e-10 mirMAP -0.179992547275748 0.00084859759025075 NA NA NA hsa-miR-181b-5p DLC1 0.488256489401108 0.00105321129419701 -1.42279739514993 6.69575982669214e-23 mirMAP -0.131453198036123 0.0082874541581851 NA NA NA hsa-miR-181b-5p EAF1 0.488256489401108 0.00105321129419701 -0.37347071039571 1.91389687543601e-05 mirMAP -0.1075909990336 0.000164494107116915 NA NA NA hsa-miR-330-5p EIF4B 0.442231058604099 0.0053308560843808 -0.213371036122907 0.00927846005206924 miRNATAP -0.121583930567148 1.00720259566484e-06 NA NA NA hsa-miR-339-5p EIF4B 0.280589919878422 0.0355660282647215 -0.213371036122907 0.00927846005206924 miRanda -0.131202132226587 1.04386561466155e-05 NA NA NA hsa-miR-342-3p EIF4B -0.319677314984262 0.0449813878317147 -0.213371036122907 0.00927846005206924 miRanda -0.127381134711691 2.69280086896855e-07 NA NA NA hsa-miR-362-3p EIF4B 0.814007335895913 2.00108618836568e-09 -0.213371036122907 0.00927846005206924 miRanda -0.120133065959791 2.94856447934838e-05 NA NA NA hsa-miR-484 EIF4B 0.0857240033709656 0.453982056282229 -0.213371036122907 0.00927846005206924 miRNAWalker2_validate -0.156463221852403 7.2363961844545e-06 NA NA NA hsa-miR-497-5p EIF4B -1.41371173021948 7.09278946477743e-17 -0.213371036122907 0.00927846005206924 miRNATAP -0.103808529523177 3.87646612451936e-06 NA NA NA hsa-miR-107 EIF4E 0.241662461253461 0.0170788899505389 -0.423618150345152 8.76394952666589e-09 miRanda -0.145690630779375 5.10144854982989e-05 NA NA NA hsa-miR-25-3p EIF4E 0.633062563556379 3.68686354834328e-10 -0.423618150345152 8.76394952666589e-09 mirMAP -0.120897171896447 0.000649613904023936 NA NA NA hsa-miR-500a-3p EIF4E 1.18913245435489 1.59516890341346e-16 -0.423618150345152 8.76394952666589e-09 MirTarget -0.100990657027664 2.96319587641026e-05 NA NA NA hsa-miR-660-5p EIF4E 0.989755850734071 5.69930767464937e-14 -0.423618150345152 8.76394952666589e-09 mirMAP -0.155553210664168 3.85299588654816e-09 NA NA NA hsa-miR-140-5p EIF4E2 -0.220106443070144 0.0140713197101242 -0.0307165992319307 0.660560144350934 miRanda -0.138995836241305 0.000258086393762208 NA NA NA hsa-miR-29a-3p EIF4E2 -0.856762511178136 4.65330336378459e-12 -0.0307165992319307 0.660560144350934 MirTarget -0.113597041826362 1.87271499311999e-05 NA NA NA hsa-miR-125b-5p EIF4EBP1 -1.35767721102906 1.16564617395164e-18 -0.0296151122465442 0.838078981735608 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.116832363024321 0.00778246256108478 17891175;26646586 Using a bioinformatics approach we have identified additional potential mRNA targets of one of the miRNAs miR-125b that are upregulated in prostate cancer and confirmed increased expression of one of these targets EIF4EBP1 in prostate cancer tissues;Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression ; prostate cancer;ovarian cancer hsa-miR-181b-5p ELOVL6 0.488256489401108 0.00105321129419701 -1.01433709478282 1.15410707798086e-06 mirMAP -0.412266139684575 1.14967553910155e-09 NA NA NA hsa-miR-181b-5p EMP2 0.488256489401108 0.00105321129419701 -0.2961927570137 0.0244099527389396 mirMAP -0.296298361509613 1.51240889807068e-12 NA NA NA hsa-miR-181b-5p EPB41L4B 0.488256489401108 0.00105321129419701 -1.96928704307134 1.79757456187987e-18 miRNATAP -0.360462374881105 2.03779917294123e-06 NA NA NA hsa-miR-181b-5p EPS15 0.488256489401108 0.00105321129419701 -0.299266773136494 8.77908615019208e-06 miRNATAP -0.126453539543329 5.55974457882669e-09 NA NA NA hsa-miR-181b-5p ERLIN2 0.488256489401108 0.00105321129419701 -0.765814822219247 2.25238859952501e-10 MirTarget -0.181481990891556 5.44161625142249e-06 NA NA NA hsa-miR-181b-5p ESR1 0.488256489401108 0.00105321129419701 -4.11885094897542 1.63160126578307e-28 miRNATAP -0.93245685386221 1.82901466028359e-13 NA NA NA hsa-miR-181b-5p EVI5 0.488256489401108 0.00105321129419701 -0.656558367861793 2.14847579134138e-11 mirMAP -0.108767267739994 0.000864299892478488 NA NA NA hsa-miR-181b-5p FAM169A 0.488256489401108 0.00105321129419701 0.365458857393713 0.13290757956596 mirMAP -0.505002472264281 8.31683679317798e-11 NA NA NA hsa-miR-181b-5p FAM46A 0.488256489401108 0.00105321129419701 -1.45135702962017 1.01521313725168e-19 mirMAP;miRNATAP -0.242846450679644 7.43686108188156e-06 NA NA NA hsa-miR-181b-5p FAM47E 0.488256489401108 0.00105321129419701 0.197698893797714 0.232506817700832 mirMAP -0.224877980302697 2.77476364991836e-05 NA NA NA hsa-miR-181b-5p FGD4 0.488256489401108 0.00105321129419701 -1.15544171645474 1.45947973849956e-12 mirMAP -0.208491827217426 0.000131797572532732 NA NA NA hsa-miR-181b-5p FGF2 0.488256489401108 0.00105321129419701 -1.08625533231299 0.000324809942833161 mirMAP -0.523910277677257 9.1015168945214e-08 NA NA NA hsa-miR-181b-5p FNDC3A 0.488256489401108 0.00105321129419701 -0.995884475839302 2.03718393267477e-13 MirTarget;mirMAP;miRNATAP -0.173833003664333 0.000127087539454222 NA NA NA hsa-miR-181b-5p GAN 0.488256489401108 0.00105321129419701 -0.684958975626295 2.31241918352254e-08 mirMAP -0.163207435435014 5.40283380623868e-05 NA NA NA hsa-miR-181b-5p GANC 0.488256489401108 0.00105321129419701 -0.013778864336826 0.89063946497633 MirTarget -0.154552846068202 1.66569752708126e-06 NA NA NA hsa-miR-181b-5p GATM 0.488256489401108 0.00105321129419701 -1.67872610104551 6.33871234809562e-13 MirTarget -0.45193088677117 4.77628229854381e-09 NA NA NA hsa-miR-181b-5p GDA 0.488256489401108 0.00105321129419701 -1.84723490700582 3.83899286012136e-06 miRNATAP -0.3929900712458 0.00289508616497044 NA NA NA hsa-miR-181b-5p GFOD1 0.488256489401108 0.00105321129419701 -0.739136473829968 1.54144336609472e-06 mirMAP -0.388676785260715 2.61455745827552e-15 NA NA NA hsa-miR-181b-5p GFRA1 0.488256489401108 0.00105321129419701 -2.5486406119615 2.43457108723549e-08 mirMAP -0.891805619611309 2.29624707713787e-09 NA NA NA hsa-miR-181b-5p GHITM 0.488256489401108 0.00105321129419701 -0.677442442991533 3.66188296517632e-14 MirTarget;miRNATAP -0.242226297113184 6.06744366083344e-17 NA NA NA hsa-miR-181b-5p GOLGA1 0.488256489401108 0.00105321129419701 -0.0571328534655402 0.442142749734858 MirTarget;miRNATAP -0.139369749492396 4.1072194522484e-09 NA NA NA hsa-miR-181b-5p GPAM 0.488256489401108 0.00105321129419701 -0.472844151955403 0.0637965177079971 MirTarget;mirMAP -0.457380185706351 2.59673752509555e-08 NA NA NA hsa-miR-181b-5p GTPBP10 0.488256489401108 0.00105321129419701 -0.208858907279597 0.0121408412268073 mirMAP -0.180967956266462 8.44032610646524e-12 NA NA NA hsa-miR-181b-5p HEMK1 0.488256489401108 0.00105321129419701 0.0638411526846525 0.448919076689463 mirMAP -0.15943267250684 3.1555471532804e-09 NA NA NA hsa-miR-181b-5p HEY2 0.488256489401108 0.00105321129419701 -1.34767831175623 1.66295690242859e-12 miRNATAP -0.325246834178081 2.82240288650486e-07 NA NA NA hsa-miR-107 HIF1A 0.241662461253461 0.0170788899505389 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate;miRTarBase;miRanda -0.436710343430652 2.03313957855482e-10 NA NA NA hsa-miR-17-5p HIF1A 0.698861147045461 2.43854106455398e-05 -0.366176828296648 0.0111002186054683 miRTarBase;MirTarget;TargetScan -0.207486649592262 6.73419034465465e-07 NA NA NA hsa-miR-20a-5p HIF1A 0.854326758727003 5.04256669663285e-07 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate;miRTarBase;MirTarget -0.245558453559623 9.83134714947215e-10 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha breast cancer hsa-miR-33a-5p HIF1A -0.767474460958522 1.09948756118522e-05 -0.366176828296648 0.0111002186054683 miRNAWalker2_validate -0.107227499920455 0.00730487730363833 NA NA NA hsa-miR-616-5p HIF1A 0.150569904638223 0.402836556304524 -0.366176828296648 0.0111002186054683 MirTarget -0.124976106072862 0.00144238259369066 NA NA NA hsa-miR-660-5p HIF1A 0.989755850734071 5.69930767464937e-14 -0.366176828296648 0.0111002186054683 MirTarget -0.249870386379118 1.21860559731773e-06 NA NA NA hsa-miR-93-5p HIF1A 1.39518349670953 2.84167728726712e-25 -0.366176828296648 0.0111002186054683 MirTarget -0.173769064325932 0.000425501783480084 NA NA NA hsa-miR-181b-5p HIPK2 0.488256489401108 0.00105321129419701 -0.239689841914744 0.0838927941290475 mirMAP;miRNATAP -0.297128209508301 1.8229823488911e-11 NA NA NA hsa-miR-181b-5p HLF 0.488256489401108 0.00105321129419701 -1.56359740264692 3.39928227602253e-08 MirTarget;miRNATAP -0.906166223170333 2.02680662950786e-24 NA NA NA hsa-miR-181b-5p HMBS 0.488256489401108 0.00105321129419701 0.408525618362018 9.51669585366333e-06 MirTarget -0.102339523846352 0.000714179744096593 NA NA NA hsa-miR-181b-5p ICOSLG 0.488256489401108 0.00105321129419701 -0.163710799030457 0.19950923039572 mirMAP -0.106120789669614 0.01071932015251 NA NA NA hsa-miR-181b-5p IDH1 0.488256489401108 0.00105321129419701 -0.49663722146977 7.27088438098223e-06 MirTarget -0.319164967831864 5.02985148736607e-20 NA NA NA hsa-miR-181b-5p IDO2 0.488256489401108 0.00105321129419701 -3.78490609470101 1.79547840614059e-19 mirMAP -0.644793744552967 5.90364961076955e-06 NA NA NA hsa-miR-181b-5p IFNGR1 0.488256489401108 0.00105321129419701 -0.35955884207507 0.0116826908041428 miRNAWalker2_validate -0.265113774857758 7.56869583693282e-09 NA NA NA hsa-miR-103a-2-5p IGF1 1.17085533927423 5.31418969120877e-09 -3.09093589123239 2.87389370715384e-21 mirMAP -0.263504392304743 0.00223342792049484 NA NA NA hsa-miR-15b-3p IGF1 0.238105490431193 0.0997721500357416 -3.09093589123239 2.87389370715384e-21 mirMAP -0.317736514699582 0.00624882495536213 NA NA NA hsa-miR-181a-5p IGF1 0.250113435902954 0.0551933249319293 -3.09093589123239 2.87389370715384e-21 mirMAP -0.504463915639783 8.50109868625984e-05 NA NA NA hsa-miR-181b-5p IGF1 0.488256489401108 0.00105321129419701 -3.09093589123239 2.87389370715384e-21 mirMAP -0.623738116833257 1.69561535563835e-08 NA NA NA hsa-miR-181c-5p IGF1 -0.00639394152050299 0.969127212255928 -3.09093589123239 2.87389370715384e-21 mirMAP -0.239250410659019 0.01885120596434 NA NA NA hsa-miR-19a-3p IGF1 1.01712596153672 2.57753201450625e-07 -3.09093589123239 2.87389370715384e-21 MirTarget -0.400144846493838 1.38857829477185e-06 NA NA NA hsa-miR-19b-3p IGF1 0.601279551368824 0.00016685097085251 -3.09093589123239 2.87389370715384e-21 MirTarget -0.48361890440052 2.97870836726975e-06 NA NA NA hsa-miR-20a-3p IGF1 -0.318177901603857 0.0467885456739855 -3.09093589123239 2.87389370715384e-21 mirMAP -0.361896843485159 0.00054680673837891 NA NA NA hsa-miR-301a-3p IGF1 0.842910511640361 1.43446467417891e-06 -3.09093589123239 2.87389370715384e-21 MirTarget -0.644215183857533 3.25465618219484e-12 NA NA NA hsa-miR-320a IGF1 0.325285936317332 0.0221415065838824 -3.09093589123239 2.87389370715384e-21 miRNATAP -0.253507903136112 0.0320941317708595 NA NA NA hsa-miR-361-5p IGF1 0.233202959858696 0.00961572812255327 -3.09093589123239 2.87389370715384e-21 PITA;mirMAP -0.379123489406991 0.0443597193507629 NA NA NA hsa-miR-362-5p IGF1 0.717921690799312 1.68392734504524e-05 -3.09093589123239 2.87389370715384e-21 mirMAP -0.221743789905403 0.026284257397644 NA NA NA hsa-miR-369-3p IGF1 -0.680843625018478 0.0155063508282041 -3.09093589123239 2.87389370715384e-21 mirMAP -0.150353974270175 0.0114686163117569 NA NA NA hsa-miR-3913-5p IGF1 0.247553671224336 0.062795011081188 -3.09093589123239 2.87389370715384e-21 mirMAP -0.347700367785319 0.00609623314715803 NA NA NA hsa-miR-409-3p IGF1 -0.499649792570937 0.0526751181520117 -3.09093589123239 2.87389370715384e-21 PITA -0.129530044963349 0.0462392123008723 NA NA NA hsa-miR-421 IGF1 0.941856334694081 6.12167297054077e-08 -3.09093589123239 2.87389370715384e-21 PITA -0.472083397878338 5.5786740474017e-07 NA NA NA hsa-miR-454-3p IGF1 0.668749059573955 2.42670710515113e-06 -3.09093589123239 2.87389370715384e-21 MirTarget -0.659716525935208 1.08682616687143e-08 NA NA NA hsa-miR-485-3p IGF1 -0.429504552347863 0.165399880918286 -3.09093589123239 2.87389370715384e-21 mirMAP -0.125118787170308 0.0219899962644741 NA NA NA hsa-miR-940 IGF1 0.453020092551484 0.0177054921651997 -3.09093589123239 2.87389370715384e-21 MirTarget;PITA;miRNATAP -0.258190444399689 0.00419588966919949 NA NA NA hsa-miR-181b-5p IL1R1 0.488256489401108 0.00105321129419701 -1.01045381057689 4.50684679449702e-13 mirMAP -0.246016811028355 1.07107101412662e-07 NA NA NA hsa-miR-181b-5p IL6ST 0.488256489401108 0.00105321129419701 -1.91925864959166 1.59476897276323e-08 mirMAP -0.297659176110622 0.00837138676157886 NA NA NA hsa-miR-181b-5p INO80B 0.488256489401108 0.00105321129419701 0.305267589114463 0.00479261589444966 miRNAWalker2_validate -0.13998065014107 6.91260218894386e-05 NA NA NA hsa-miR-181b-5p INSR 0.488256489401108 0.00105321129419701 -0.278293402111066 0.00785689311731476 mirMAP -0.192792987659091 1.02091731606267e-08 NA NA NA hsa-miR-181b-5p IQGAP2 0.488256489401108 0.00105321129419701 -1.09691498655628 9.21601276995956e-14 miRNATAP -0.41433641854952 3.04425917921197e-18 NA NA NA hsa-miR-181b-5p IRS2 0.488256489401108 0.00105321129419701 -0.811999517586244 8.14991854093828e-06 MirTarget;miRNATAP -0.464615763465426 1.1767859809815e-15 NA NA NA hsa-miR-181b-5p ITGA1 0.488256489401108 0.00105321129419701 -0.675046465429795 1.83477212641831e-07 mirMAP -0.17356111081698 4.57364400546711e-05 NA NA NA hsa-miR-181b-5p ITSN1 0.488256489401108 0.00105321129419701 -0.745784549212654 1.16990524702238e-11 miRNATAP -0.173554622209751 1.86588371838655e-06 NA NA NA hsa-miR-181b-5p IYD 0.488256489401108 0.00105321129419701 -2.66179429977146 1.10383788101266e-13 mirMAP -0.686501158073007 7.68640272104804e-09 NA NA NA hsa-miR-181b-5p JAZF1 0.488256489401108 0.00105321129419701 -0.00573099240982522 0.96939333269824 MirTarget;miRNATAP -0.20234329165734 2.8445229531137e-05 NA NA NA hsa-miR-181b-5p JMY 0.488256489401108 0.00105321129419701 -0.0723925290319816 0.482620332419229 MirTarget -0.190802077897587 7.44084137539522e-09 NA NA NA hsa-miR-181b-5p KALRN 0.488256489401108 0.00105321129419701 -0.965609985856982 5.18991450299309e-12 MirTarget -0.19836929536185 2.04135961046944e-05 NA NA NA hsa-miR-181b-5p KANK1 0.488256489401108 0.00105321129419701 -0.665033230225995 7.24717327382789e-06 MirTarget;miRNATAP -0.217058069474394 7.57171588042218e-06 NA NA NA hsa-miR-181b-5p KAT2B 0.488256489401108 0.00105321129419701 -0.938558773689222 1.89276182546283e-10 miRNAWalker2_validate;miRTarBase;MirTarget -0.457990357788594 9.28981291080347e-23 NA NA NA hsa-miR-181b-5p KBTBD7 0.488256489401108 0.00105321129419701 -0.935413933152499 3.50066588121242e-06 mirMAP -0.18069132373 0.00663093120544326 NA NA NA hsa-miR-181b-5p KCNMA1 0.488256489401108 0.00105321129419701 -1.61689069754613 3.52157504789145e-11 miRNATAP -0.288278276628586 0.000399476528351128 NA NA NA hsa-miR-181b-5p KDELR2 0.488256489401108 0.00105321129419701 -0.114979701289307 0.117011025384267 mirMAP -0.134595174582584 9.27539453471284e-09 NA NA NA hsa-miR-181b-5p KLF12 0.488256489401108 0.00105321129419701 -0.863221902725629 5.4142350807271e-09 mirMAP -0.391881112421738 1.42240874764241e-16 NA NA NA hsa-miR-181b-5p KLF15 0.488256489401108 0.00105321129419701 -0.258492610641029 0.233857215291637 MirTarget;miRNATAP -0.592776786977719 2.90270791267021e-18 NA NA NA hsa-miR-181b-5p KLF6 0.488256489401108 0.00105321129419701 -1.43852959018658 4.46638206050043e-20 miRNATAP -0.235936980083028 9.42607903875365e-06 NA NA NA hsa-miR-181b-5p KLF9 0.488256489401108 0.00105321129419701 -1.35905833834713 1.22932810880238e-12 mirMAP -0.612400156392753 7.19443960440113e-24 NA NA NA hsa-miR-181b-5p KLHL15 0.488256489401108 0.00105321129419701 -1.43616317329618 4.62856180062188e-29 mirMAP;miRNATAP -0.237211100714084 9.0404508427053e-08 NA NA NA hsa-miR-181b-5p KLHL2 0.488256489401108 0.00105321129419701 -1.16669881935719 4.68056312110186e-18 miRNATAP -0.401494260768221 4.98148474153148e-20 NA NA NA hsa-miR-181b-5p KPNA1 0.488256489401108 0.00105321129419701 -0.315101680458858 2.00299187243101e-06 MirTarget;miRNATAP -0.12537756436499 4.56043164022635e-09 NA NA NA hsa-miR-181b-5p LARP4 0.488256489401108 0.00105321129419701 -0.606974985036527 4.17599364737609e-12 MirTarget;miRNATAP -0.31541091413399 3.43274288049146e-31 NA NA NA hsa-miR-181b-5p LEPROT 0.488256489401108 0.00105321129419701 -0.766289999290305 0.00143475208504872 MirTarget -0.246459837803959 0.00174384932132757 NA NA NA hsa-miR-181b-5p LIG4 0.488256489401108 0.00105321129419701 -0.526853993165358 1.7283249935127e-05 MirTarget -0.156220402450582 9.96587903366717e-05 NA NA NA hsa-miR-181b-5p LIN7A 0.488256489401108 0.00105321129419701 -0.539444523114043 0.000887680837455538 mirMAP -0.418821397200742 3.61277916908684e-16 NA NA NA hsa-miR-181b-5p LIN7C 0.488256489401108 0.00105321129419701 -0.778211251236792 5.38883335125652e-24 mirMAP;miRNATAP -0.178250132772279 5.88494625460495e-12 NA NA NA hsa-miR-181b-5p LMAN1 0.488256489401108 0.00105321129419701 -0.935085324207848 9.35847745172939e-17 MirTarget -0.219979209122281 4.47020306760259e-09 NA NA NA hsa-miR-181b-5p LMBRD2 0.488256489401108 0.00105321129419701 -0.379556645489973 0.0216178458484519 MirTarget;mirMAP -0.27256662376182 3.31195134854114e-07 NA NA NA hsa-miR-181b-5p LNPEP 0.488256489401108 0.00105321129419701 0.0381901216213942 0.796318936192664 mirMAP -0.123213166021816 0.0105853812238958 NA NA NA hsa-miR-181b-5p LONP2 0.488256489401108 0.00105321129419701 -1.15752181481711 1.20062079208437e-15 mirMAP -0.38913258616929 1.6122770850947e-16 NA NA NA hsa-miR-181b-5p LRAT 0.488256489401108 0.00105321129419701 -4.13158473453449 2.38539906898597e-44 mirMAP -0.350904560479799 0.00111585158564376 NA NA NA hsa-miR-181b-5p LRP6 0.488256489401108 0.00105321129419701 -0.374410866893442 0.0013487864538849 mirMAP -0.118078225864745 0.00198310355409659 NA NA NA hsa-miR-181b-5p LRRC8D 0.488256489401108 0.00105321129419701 0.302080319292119 0.000965409775769997 MirTarget -0.150735024599196 3.49014390500572e-07 NA NA NA hsa-miR-181b-5p LRRFIP1 0.488256489401108 0.00105321129419701 -0.587622691682438 1.09608882717065e-10 MirTarget -0.122870430539651 4.58252949580185e-05 NA NA NA hsa-miR-181b-5p LUZP2 0.488256489401108 0.00105321129419701 1.08272464345489 0.00317141578198537 mirMAP -0.403233217903606 0.000778420166449559 NA NA NA hsa-miR-181b-5p LYRM1 0.488256489401108 0.00105321129419701 -0.775358606006421 8.6004568006887e-13 MirTarget -0.269478146580459 2.12179173814499e-14 NA NA NA hsa-miR-181b-5p LYRM7 0.488256489401108 0.00105321129419701 -0.285114105890549 0.000746869763807281 mirMAP -0.176985069986944 6.02236498240913e-11 NA NA NA hsa-miR-181b-5p LYSMD3 0.488256489401108 0.00105321129419701 -0.504034718871008 9.84126014307241e-07 mirMAP -0.243094121263968 1.81814648251232e-13 NA NA NA hsa-miR-181b-5p MAGI3 0.488256489401108 0.00105321129419701 -0.591034618812482 1.94730768066587e-06 MirTarget -0.138766709611934 0.000683433116032401 NA NA NA hsa-miR-181b-5p MAN1A2 0.488256489401108 0.00105321129419701 -0.493930822804955 0.000153700923534437 mirMAP -0.138798480058296 0.0011689394697069 NA NA NA hsa-miR-181b-5p MAP3K13 0.488256489401108 0.00105321129419701 -0.448996281023736 0.0575259551730977 mirMAP -0.272541117721565 0.00039983088740065 NA NA NA hsa-miR-181b-5p MAP3K2 0.488256489401108 0.00105321129419701 -0.770538748173389 6.13734867546361e-08 mirMAP -0.179966533909382 0.000126100967797753 NA NA NA hsa-miR-181b-5p MAP3K9 0.488256489401108 0.00105321129419701 0.681574787109281 3.69974619451209e-07 mirMAP -0.11289028667318 0.0108959392866681 NA NA NA hsa-miR-181b-5p MBNL2 0.488256489401108 0.00105321129419701 -1.32208886120192 1.96175870553543e-18 MirTarget;miRNATAP -0.232666303233361 5.09560915535265e-06 NA NA NA hsa-miR-181b-5p MBNL3 0.488256489401108 0.00105321129419701 -0.597245834128655 0.0142379871483953 mirMAP -0.217365679302565 0.00638945619654699 NA NA NA hsa-miR-181b-5p MCC 0.488256489401108 0.00105321129419701 -2.36915505634884 5.46995786737825e-22 MirTarget -0.186852753088202 0.0274464436745467 NA NA NA hsa-miR-181b-5p MEGF9 0.488256489401108 0.00105321129419701 -0.767121149729698 4.19664132638782e-10 MirTarget -0.186817572281339 4.10481932153354e-06 NA NA NA hsa-miR-181b-5p MEPCE 0.488256489401108 0.00105321129419701 0.255283721593848 0.00176043051414384 miRNAWalker2_validate -0.132053343405733 5.38159780833237e-07 NA NA NA hsa-miR-181b-5p MFAP3L 0.488256489401108 0.00105321129419701 -2.99511248620354 4.97173912475439e-19 mirMAP;miRNATAP -1.03781549854935 2.30763502509261e-21 NA NA NA hsa-miR-181b-5p MFSD8 0.488256489401108 0.00105321129419701 -0.3605492062265 6.85176011402975e-06 MirTarget -0.100217071712647 0.000130375364338969 NA NA NA hsa-miR-181b-5p MIER3 0.488256489401108 0.00105321129419701 -0.289689451855984 0.00044472169352925 MirTarget;miRNATAP -0.169730173681719 1.3195551531538e-10 NA NA NA hsa-miR-181b-5p MON1B 0.488256489401108 0.00105321129419701 -0.0943712249946733 0.255339014596288 mirMAP -0.106062520730226 7.57870982795256e-05 NA NA NA hsa-miR-181b-5p MORC3 0.488256489401108 0.00105321129419701 -0.493622872657661 7.75189399922391e-06 MirTarget -0.1777186147211 7.71407478874961e-07 NA NA NA hsa-miR-181b-5p MPP5 0.488256489401108 0.00105321129419701 -0.288077654324143 0.00156212311296768 MirTarget -0.186364240958831 1.66154880493207e-10 NA NA NA hsa-miR-181b-5p MRO 0.488256489401108 0.00105321129419701 -2.92283865752237 1.66304468359331e-30 mirMAP -0.597035693652266 9.17517440008746e-12 NA NA NA hsa-miR-181b-5p MRPS25 0.488256489401108 0.00105321129419701 0.0188558426537258 0.840264321840341 mirMAP -0.120754847978789 6.47664042703703e-05 NA NA NA hsa-miR-181b-5p MTOR 0.488256489401108 0.00105321129419701 0.127337008584315 0.234493252196033 miRNAWalker2_validate -0.222677068776147 6.82613635172636e-11 NA NA NA hsa-miR-181b-5p MYO5B 0.488256489401108 0.00105321129419701 -0.176936939172443 0.203327370730779 mirMAP -0.311706557903158 1.7557541578634e-12 NA NA NA hsa-miR-181b-5p MYO9A 0.488256489401108 0.00105321129419701 -1.00759496257002 7.50264844143602e-06 mirMAP -0.23594270315154 0.00144804532065528 NA NA NA hsa-miR-181b-5p NAA30 0.488256489401108 0.00105321129419701 -0.454004458262681 8.01308724482182e-10 mirMAP -0.108278485449583 8.36100022820392e-06 NA NA NA hsa-miR-181b-5p NDFIP2 0.488256489401108 0.00105321129419701 -0.965495107934266 1.87718124112122e-18 mirMAP -0.247064458758544 1.56527663101575e-11 NA NA NA hsa-miR-181b-5p NEK3 0.488256489401108 0.00105321129419701 0.398398228720978 0.0233441139517675 miRNAWalker2_validate -0.279182502290718 9.0191751853468e-07 NA NA NA hsa-miR-181b-5p NFIB 0.488256489401108 0.00105321129419701 -0.473125743246742 0.000230272053316789 miRNATAP -0.112830195352577 0.00742939681176461 NA NA NA hsa-miR-181b-5p NHLRC2 0.488256489401108 0.00105321129419701 -1.1330149468621 2.05949478884869e-14 mirMAP -0.111877500292654 0.025298554329014 NA NA NA hsa-miR-181b-5p NKAIN2 0.488256489401108 0.00105321129419701 0.282151651650571 0.496700380775914 MirTarget;miRNATAP -0.328018629024826 0.0155102783136241 NA NA NA hsa-miR-181b-5p NNT 0.488256489401108 0.00105321129419701 -1.00636428911703 1.46289096561224e-10 MirTarget;mirMAP -0.378580519646715 1.06404373137532e-13 NA NA NA hsa-miR-181b-5p NOL4 0.488256489401108 0.00105321129419701 -3.34785387311656 6.2589012007234e-19 mirMAP;miRNATAP -0.511486834468801 6.45774136480916e-05 NA NA NA hsa-miR-181b-5p NR1D2 0.488256489401108 0.00105321129419701 -0.431324257008006 4.19730114867347e-05 miRNATAP -0.185985364652182 4.99649745975419e-08 NA NA NA hsa-miR-181b-5p NR3C1 0.488256489401108 0.00105321129419701 -0.4313634018742 3.79689238088369e-06 mirMAP;miRNATAP -0.22908968686461 1.4146603968692e-14 NA NA NA hsa-miR-181b-5p OCIAD1 0.488256489401108 0.00105321129419701 -0.363945364154922 2.88737977727414e-07 MirTarget -0.106340014094103 4.32148383508894e-06 NA NA NA hsa-miR-181b-5p ONECUT2 0.488256489401108 0.00105321129419701 0.120890541524141 0.551384233388767 miRNATAP -0.39813190440824 8.91061008627239e-10 NA NA NA hsa-miR-181b-5p OSBPL11 0.488256489401108 0.00105321129419701 -0.799904171828814 5.51246180930698e-12 mirMAP -0.181956901057965 2.27267984348015e-06 NA NA NA hsa-miR-181b-5p OTUD4 0.488256489401108 0.00105321129419701 -0.781147538845887 2.89406618341624e-12 mirMAP;miRNATAP -0.12119326423328 0.0011858364532463 NA NA NA hsa-miR-181b-5p PAH 0.488256489401108 0.00105321129419701 -1.52529569245637 3.89232247248622e-07 mirMAP -0.798906311595117 8.28060611340199e-17 NA NA NA hsa-miR-181b-5p PANK1 0.488256489401108 0.00105321129419701 -1.78611804711646 1.3683840906107e-26 mirMAP -0.389465018551984 7.8042991270847e-12 NA NA NA hsa-miR-181b-5p PCYOX1 0.488256489401108 0.00105321129419701 -0.710952952600329 8.62737880229856e-10 mirMAP -0.278018118123087 1.20321689740947e-13 NA NA NA hsa-miR-181b-5p PDCD6IP 0.488256489401108 0.00105321129419701 -0.0996773536816402 0.0954765940413755 miRNATAP -0.104831362602946 3.84001514613507e-08 NA NA NA hsa-miR-181b-5p PDE4DIP 0.488256489401108 0.00105321129419701 -0.268391772056326 0.0604161803169821 mirMAP -0.306617891821878 1.76198320183446e-11 NA NA NA hsa-miR-181b-5p PDHX 0.488256489401108 0.00105321129419701 -0.357960061322459 1.41986259575707e-06 miRNAWalker2_validate -0.18548710492398 4.00606242537035e-15 NA NA NA hsa-miR-181b-5p PDIK1L 0.488256489401108 0.00105321129419701 -0.0468630905538001 0.608073460423057 MirTarget;mirMAP -0.170220598980027 5.63481141361996e-09 NA NA NA hsa-miR-181b-5p PDK4 0.488256489401108 0.00105321129419701 -2.10593846974081 2.90436387273985e-14 miRNATAP -0.898754768262503 2.51839642855176e-24 NA NA NA hsa-miR-181b-5p PDLIM5 0.488256489401108 0.00105321129419701 -1.19395917699233 9.15580988544115e-26 mirMAP -0.150138356163127 0.000133458965863036 NA NA NA hsa-miR-106a-5p PDPK1 -0.464229535269236 0.009724944358047 0.309856812256619 0.0145897035970451 mirMAP -0.106603481622112 0.00191993221102484 NA NA NA hsa-miR-128-3p PDPK1 0.289735108018712 0.0114419474207889 0.309856812256619 0.0145897035970451 miRNAWalker2_validate -0.106949401229151 0.0492467114400439 NA NA NA hsa-miR-148b-5p PDPK1 0.295777213389605 0.0255749859535438 0.309856812256619 0.0145897035970451 mirMAP -0.104191728947125 0.0265785096620784 NA NA NA hsa-miR-22-5p PDPK1 -0.630365901263172 3.32415348030414e-05 0.309856812256619 0.0145897035970451 miRNATAP -0.114858817985206 0.004539264565349 NA NA NA hsa-miR-24-3p PDPK1 -0.257825594021966 0.00689742600215061 0.309856812256619 0.0145897035970451 miRNAWalker2_validate -0.189377775001018 0.00377818335280003 NA NA NA hsa-miR-27a-3p PDPK1 -0.370807380415112 0.00875721956202713 0.309856812256619 0.0145897035970451 miRNATAP -0.12746674939881 0.00357863446842311 NA NA NA hsa-miR-324-3p PDPK1 0.260348469146494 0.0506141704203545 0.309856812256619 0.0145897035970451 mirMAP -0.133875113382166 0.00407187982303137 NA NA NA hsa-miR-326 PDPK1 -1.881935132554 1.68087316863775e-21 0.309856812256619 0.0145897035970451 mirMAP -0.115285864383535 0.000115621382458437 NA NA NA hsa-miR-330-3p PDPK1 -0.332364259424489 0.0316051913061459 0.309856812256619 0.0145897035970451 mirMAP -0.199719327448706 8.51522334736582e-07 NA NA NA hsa-miR-330-5p PDPK1 0.442231058604099 0.0053308560843808 0.309856812256619 0.0145897035970451 mirMAP -0.174352569124449 6.44046033884862e-06 NA NA NA hsa-miR-331-3p PDPK1 -0.283974346994635 0.0373785411053202 0.309856812256619 0.0145897035970451 miRNAWalker2_validate -0.14393772894958 0.0015300062995931 NA NA NA hsa-miR-342-3p PDPK1 -0.319677314984262 0.0449813878317147 0.309856812256619 0.0145897035970451 mirMAP -0.202682473172801 1.2852571763811e-07 NA NA NA hsa-miR-424-5p PDPK1 -2.62653257498508 2.38997974737991e-50 0.309856812256619 0.0145897035970451 mirMAP -0.106052465451978 0.000611771334502943 NA NA NA hsa-miR-542-3p PDPK1 -1.31351015149842 3.64642423288576e-22 0.309856812256619 0.0145897035970451 mirMAP -0.149412531526728 0.000555422280439471 NA NA NA hsa-miR-590-5p PDPK1 -0.103355559980404 0.310027295317092 0.309856812256619 0.0145897035970451 miRanda -0.154730721244174 0.0118516546451218 NA NA NA hsa-miR-744-5p PDPK1 -0.378868377317939 0.00125071229180016 0.309856812256619 0.0145897035970451 miRNAWalker2_validate -0.143178711893691 0.0067023429085085 NA NA NA hsa-miR-766-3p PDPK1 0.199979324759329 0.257230732626744 0.309856812256619 0.0145897035970451 mirMAP -0.152946333354899 1.15508230226764e-05 NA NA NA hsa-miR-181b-5p PDXDC1 0.488256489401108 0.00105321129419701 -0.618637369600821 4.64277780662657e-11 MirTarget -0.209178404402996 8.18676228090527e-12 NA NA NA hsa-miR-181b-5p PER2 0.488256489401108 0.00105321129419701 -0.671467371709996 2.18508455717704e-08 MirTarget -0.186511272683123 2.21976238415635e-06 NA NA NA hsa-miR-181b-5p PER3 0.488256489401108 0.00105321129419701 -0.848602701375337 1.12316239584011e-06 MirTarget -0.295446922785539 2.09694736313518e-07 NA NA NA hsa-miR-181b-5p PGPEP1 0.488256489401108 0.00105321129419701 0.167322965185669 0.143077647806586 mirMAP -0.150383497544233 4.829363611668e-05 NA NA NA hsa-miR-181b-5p PGRMC2 0.488256489401108 0.00105321129419701 -0.34369815717862 7.20024903580005e-05 mirMAP -0.223407583525163 3.46415940006866e-16 NA NA NA hsa-miR-181b-5p PHACTR4 0.488256489401108 0.00105321129419701 -0.269981995883152 0.000685262779050799 MirTarget -0.109656457148818 2.12851709036252e-05 NA NA NA hsa-miR-181b-5p PHKG2 0.488256489401108 0.00105321129419701 0.0670569896420519 0.461670030596112 mirMAP -0.112966880008944 0.000125745640576018 NA NA NA hsa-miR-181b-5p PI4K2B 0.488256489401108 0.00105321129419701 -0.759829344931532 1.35039006281556e-09 MirTarget;miRNATAP -0.412772797118688 7.13930402934494e-26 NA NA NA hsa-miR-17-5p PIK3CA 0.698861147045461 2.43854106455398e-05 -0.417502897789422 0.000144089141837096 miRNAWalker2_validate -0.140034439363479 1.22830047865626e-05 NA NA NA hsa-miR-339-5p PIK3CA 0.280589919878422 0.0355660282647215 -0.417502897789422 0.000144089141837096 miRanda -0.161250958910826 6.10867364493006e-05 NA NA NA hsa-miR-501-5p PIK3CA 1.15231083477882 2.98906150004088e-10 -0.417502897789422 0.000144089141837096 mirMAP -0.110297544989421 0.000121810192831398 NA NA NA hsa-miR-126-5p PIK3CB -0.428561469405594 6.6035585844222e-05 0.100967159570933 0.165951003911767 mirMAP -0.182730257201379 1.71015167377407e-08 NA NA NA hsa-miR-204-5p PIK3CB -0.537962150012103 0.0330895493358849 0.100967159570933 0.165951003911767 miRNATAP -0.108408817404481 9.83805003133513e-16 NA NA NA hsa-miR-32-5p PIK3CB 0.0806126674664016 0.548984992497432 0.100967159570933 0.165951003911767 miRNATAP -0.140663620385439 6.63155819716864e-08 NA NA NA hsa-miR-1468-5p PIK3CD -1.21475558175193 2.52286949987832e-09 -0.877858532886072 2.39332269929579e-06 MirTarget -0.114605918546385 0.00956114952826845 NA NA NA hsa-miR-30b-3p PIK3CD -0.439724365151373 0.000947180503583586 -0.877858532886072 2.39332269929579e-06 MirTarget -0.241027174305288 0.000454965508091255 NA NA NA hsa-miR-30d-5p PIK3CD 0.718283816348023 2.47422074061352e-08 -0.877858532886072 2.39332269929579e-06 MirTarget;miRNATAP -0.313277633599958 7.26196135533465e-06 NA NA NA hsa-miR-30e-5p PIK3CD -0.627815042856657 3.02205690184908e-10 -0.877858532886072 2.39332269929579e-06 MirTarget -0.253648851782905 0.00528999528593308 NA NA NA hsa-miR-616-5p PIK3CD 0.150569904638223 0.402836556304524 -0.877858532886072 2.39332269929579e-06 MirTarget -0.206581353665342 5.02538338243613e-05 NA NA NA hsa-miR-103a-3p PIK3R1 0.765568928457606 3.05497476509383e-12 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.187692597616198 0.00702590214654354 NA NA NA hsa-miR-106b-5p PIK3R1 0.648901865047099 8.24870862047885e-09 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.369244291882445 4.59379549667075e-08 NA NA NA hsa-miR-1301-3p PIK3R1 1.12156714169769 4.22404125385203e-10 -0.891953424131491 1.38465728969785e-08 MirTarget -0.26088137729301 3.97606431390706e-10 NA NA NA hsa-miR-132-3p PIK3R1 0.323796239695997 0.00272093067935091 -0.891953424131491 1.38465728969785e-08 MirTarget -0.517351445825174 2.17222827385203e-13 NA NA NA hsa-miR-15b-5p PIK3R1 0.230566941413564 0.0824765001857479 -0.891953424131491 1.38465728969785e-08 MirTarget -0.132325827339178 0.0249531550846148 NA NA NA hsa-miR-17-5p PIK3R1 0.698861147045461 2.43854106455398e-05 -0.891953424131491 1.38465728969785e-08 MirTarget;TargetScan;miRNATAP -0.213954808771155 3.8587060059728e-06 NA NA NA hsa-miR-185-5p PIK3R1 0.480006257154717 6.35758891340152e-07 -0.891953424131491 1.38465728969785e-08 miRNATAP -0.255181123475439 0.00153792085091181 NA NA NA hsa-miR-188-5p PIK3R1 1.11646899351496 9.56686958408598e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.178093775716465 5.33015486626271e-05 NA NA NA hsa-miR-200c-3p PIK3R1 -0.104675615392797 0.716957669484981 -0.891953424131491 1.38465728969785e-08 mirMAP -0.105107802462856 9.06963579759966e-05 NA NA NA hsa-miR-20a-5p PIK3R1 0.854326758727003 5.04256669663285e-07 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.137431012149634 0.00237710222818209 NA NA NA hsa-miR-21-5p PIK3R1 1.51084295924322 1.54551622173259e-34 -0.891953424131491 1.38465728969785e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.626634426633867 6.01244523464713e-31 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer cell migration breast cancer hsa-miR-212-3p PIK3R1 -0.288359631986802 0.100392159518997 -0.891953424131491 1.38465728969785e-08 MirTarget -0.258090192317157 3.95293509038579e-09 NA NA NA hsa-miR-221-3p PIK3R1 1.12244756358612 3.48370308238012e-13 -0.891953424131491 1.38465728969785e-08 MirTarget -0.217914846238424 7.87055620620445e-06 NA NA NA hsa-miR-222-3p PIK3R1 1.08574156066353 1.76407192348131e-11 -0.891953424131491 1.38465728969785e-08 MirTarget -0.256619417997498 3.41697791848384e-08 NA NA NA hsa-miR-324-3p PIK3R1 0.260348469146494 0.0506141704203545 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.281792149179102 1.26555231509763e-06 NA NA NA hsa-miR-330-3p PIK3R1 -0.332364259424489 0.0316051913061459 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRNATAP -0.212492102885122 3.44445995574159e-05 NA NA NA hsa-miR-338-5p PIK3R1 -0.221898432884726 0.252390988727086 -0.891953424131491 1.38465728969785e-08 PITA -0.143685656767977 0.000366657184559181 NA NA NA hsa-miR-409-3p PIK3R1 -0.499649792570937 0.0526751181520117 -0.891953424131491 1.38465728969785e-08 mirMAP -0.110448878014769 0.000237041711390918 NA NA NA hsa-miR-493-5p PIK3R1 -0.198321662045422 0.502870277689198 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.103739426368655 7.76271840065789e-05 NA NA NA hsa-miR-582-5p PIK3R1 -0.680189083316822 0.00103755166534107 -0.891953424131491 1.38465728969785e-08 mirMAP -0.138461163257927 0.00021364752999012 NA NA NA hsa-miR-589-3p PIK3R1 1.16846704028095 5.88525574424201e-11 -0.891953424131491 1.38465728969785e-08 mirMAP -0.21021578613876 1.13421126603334e-06 NA NA NA hsa-miR-590-5p PIK3R1 -0.103355559980404 0.310027295317092 -0.891953424131491 1.38465728969785e-08 MirTarget;PITA;miRanda;miRNATAP -0.299776876388425 9.9413226282672e-05 NA NA NA hsa-miR-629-3p PIK3R1 -0.315338123880353 0.119091248294946 -0.891953424131491 1.38465728969785e-08 MirTarget -0.182940394280375 3.19896248240917e-06 NA NA NA hsa-miR-93-5p PIK3R1 1.39518349670953 2.84167728726712e-25 -0.891953424131491 1.38465728969785e-08 MirTarget;miRNATAP -0.319783065556515 2.89613370212511e-09 NA NA NA hsa-miR-126-3p PIK3R2 -0.652349350198172 9.37876280344772e-09 0.902461657566753 1.95242785807378e-14 miRNAWalker2_validate;miRTarBase -0.307009584408785 1.4469316595199e-09 25240815;26384552;27578985;21249429;26191164 MiR 126 3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2; LRP6 and PIK3R2 were identified as targets of miR-126-3p; Silencing LRP6 and PIK3R2 had similar effects of miR-126-3p restoration on metastasis and angiogenesis individually in HCC cells; Furthermore the miR-126-3p level was inversely correlated with LRP6 and PIK3R2 in HCC tissues; In addition the rescue experiments indicated that the metastasis and angiogenesis functions of miR-126-3p were mediated by LRP6 and PIK3R2;MicroRNA 126 suppresses proliferation of undifferentiated BRAFV600E and BRAFWT thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K AKT proliferation survival signalling pathway; In addition miR-126 was found to act as proliferation suppressor targeting PIK3R2 gene and reducing p85β a regulatory subunit of PI3K kinase protein translation and lower AKT kinase activity;MiR 126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2 mediated PI3K/Akt signaling pathway; A direct regulatory relationship between miR-126 and the PIK3R2 gene was demonstrated by luciferase reporter assays; Quantitative real-time polymerase chain reaction was used to measure miR-126 and PIK3R2 expressions; Luciferase assays showed that miR-126 significantly inhibited the PIK3R2 3' untranslated region 3'UTR luciferase reporter activity P<0.05; Overexpression of miR-126 negatively regulated the target gene PIK3R2 and further inhibited the PI3K/Akt signaling pathway thereby inhibiting proliferation migration and invasion and promoting apoptosis in BLS cells;Endothelial specific intron derived miR 126 is down regulated in human breast cancer and targets both VEGFA and PIK3R2; VEGFA and PIK3R2 were confirmed as the targets of miR-126 by luciferase reporter assay and Western blot;Restoration of miR-126 in EC109 cells induced a reduction in PIK3R2 protein levels accompanied with a substantial reduction in phosphorylated AKT levels in EC109 cells suggesting impairment in PI3K/AKT signaling pathway; The luciferase reporter assay confirmed that PIK3R2 was a direct target of miR-126; Taken together our study suggests that miR-126 functions as a potential tumor suppressor in ESCC progression via regulating PI3K/AKT signaling pathway partly by targeting PIK3R2 and targeting of miR-126 may provide a novel strategy for the diagnosis and treatment of ESCC metastasis;poor survival;;;progression liver cancer;thyroid cancer;bladder cancer;breast cancer;esophageal cancer hsa-miR-28-5p PIK3R2 -0.430964830599964 2.67367257252925e-06 0.902461657566753 1.95242785807378e-14 miRanda -0.216513318430191 0.000794318920407844 NA NA NA hsa-miR-30a-5p PIK3R2 -0.626257932887855 0.000108198196973765 0.902461657566753 1.95242785807378e-14 miRNATAP -0.144672134574065 6.66511974688791e-05 NA NA NA hsa-miR-30e-5p PIK3R2 -0.627815042856657 3.02205690184908e-10 0.902461657566753 1.95242785807378e-14 miRNATAP -0.27051427660089 3.48529317139267e-06 NA NA NA hsa-miR-3607-3p PIK3R2 -2.15518588554493 1.03390728226728e-23 0.902461657566753 1.95242785807378e-14 mirMAP;miRNATAP -0.192639313478842 2.68262287342929e-14 NA NA NA hsa-miR-19a-3p PIK3R3 1.01712596153672 2.57753201450625e-07 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.104972668125809 0.000194207587349022 NA NA NA hsa-miR-19b-3p PIK3R3 0.601279551368824 0.00016685097085251 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.156884173334155 7.42851910353984e-06 NA NA NA hsa-miR-222-5p PIK3R3 0.125716360553359 0.487423909991138 0.635454203069077 2.81455381573105e-08 mirMAP -0.124074211713995 7.25281139850942e-05 NA NA NA hsa-miR-26b-5p PIK3R3 -1.10804856399744 4.14176110314282e-22 0.635454203069077 2.81455381573105e-08 miRNATAP -0.11879971388214 0.0117895234047857 NA NA NA hsa-miR-32-5p PIK3R3 0.0806126674664016 0.548984992497432 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.115094122727672 0.00654760226880116 NA NA NA hsa-miR-331-3p PIK3R3 -0.283974346994635 0.0373785411053202 0.635454203069077 2.81455381573105e-08 miRNAWalker2_validate;PITA -0.141431444954819 0.000659359723681179 NA NA NA hsa-miR-335-3p PIK3R3 -0.275199247483111 0.106629165248783 0.635454203069077 2.81455381573105e-08 mirMAP -0.159933987443154 1.18680673169693e-06 NA NA NA hsa-miR-454-3p PIK3R3 0.668749059573955 2.42670710515113e-06 0.635454203069077 2.81455381573105e-08 mirMAP -0.155284428603942 8.0835303918136e-05 NA NA NA hsa-miR-590-5p PIK3R3 -0.103355559980404 0.310027295317092 0.635454203069077 2.81455381573105e-08 miRanda -0.243402254613955 1.30668545381547e-05 NA NA NA hsa-miR-624-5p PIK3R3 -0.639533773668123 6.79146620944254e-06 0.635454203069077 2.81455381573105e-08 MirTarget -0.124942360560089 0.00156005977445166 NA NA NA hsa-miR-92a-3p PIK3R3 0.212391012518195 0.134292268089997 0.635454203069077 2.81455381573105e-08 MirTarget;miRNATAP -0.21036606255577 1.06004328001549e-07 NA NA NA hsa-miR-107 PIK3R5 0.241662461253461 0.0170788899505389 -0.89989526759384 1.62789758196776e-07 miRanda -0.349504238477674 3.20976138937126e-05 NA NA NA hsa-miR-181b-5p PITPNC1 0.488256489401108 0.00105321129419701 0.167033920726064 0.20212856268457 mirMAP -0.276332092271579 3.61656786920082e-11 NA NA NA hsa-miR-181b-5p PJA2 0.488256489401108 0.00105321129419701 -0.547154205949659 1.53194178694233e-08 mirMAP -0.182737048802674 6.7852682384658e-09 NA NA NA hsa-miR-181b-5p PLA2G12A 0.488256489401108 0.00105321129419701 -0.791023748042462 1.18231931629012e-15 mirMAP -0.187398478397273 1.16778168992629e-08 NA NA NA hsa-miR-181b-5p PLCL2 0.488256489401108 0.00105321129419701 -0.522483808057969 0.00170145019411227 miRNATAP -0.190909979212524 0.000448662867766351 NA NA NA hsa-miR-181b-5p PLEKHA3 0.488256489401108 0.00105321129419701 -0.403395146399148 1.65329256934451e-07 MirTarget -0.181059458183546 2.31339698175958e-13 NA NA NA hsa-miR-181b-5p PLS1 0.488256489401108 0.00105321129419701 -0.343978850494421 0.037888216094636 MirTarget;miRNATAP -0.127817037139185 0.018290923948897 NA NA NA hsa-miR-181b-5p PPARA 0.488256489401108 0.00105321129419701 -0.607171871846345 3.30592576448713e-05 miRNATAP -0.44197902311784 4.35491871601128e-22 NA NA NA hsa-miR-181b-5p PPARGC1B 0.488256489401108 0.00105321129419701 -0.171170839113116 0.38344943912292 mirMAP -0.321195405563286 3.94016241488117e-07 NA NA NA hsa-miR-181b-5p PPIP5K2 0.488256489401108 0.00105321129419701 -0.121113001332652 0.185235241842637 MirTarget;miRNATAP -0.122897280915088 3.17773373286669e-05 NA NA NA hsa-miR-181b-5p PPM1B 0.488256489401108 0.00105321129419701 -0.275687173108442 0.000442253436356182 mirMAP;miRNATAP -0.114997723841133 6.11079243851445e-06 NA NA NA hsa-miR-181b-5p PPM1L 0.488256489401108 0.00105321129419701 -0.358173274286561 0.0774099414261059 mirMAP -0.324347698608955 7.48558798267414e-07 NA NA NA hsa-miR-181b-5p PPP3R1 0.488256489401108 0.00105321129419701 -0.348267739030591 8.30932335829799e-08 MirTarget;miRNATAP -0.13726473522507 5.36198845965272e-11 NA NA NA hsa-miR-181b-5p PRDX3 0.488256489401108 0.00105321129419701 -0.775710711220344 3.34987294348607e-14 MirTarget -0.209590675235906 5.39948655363732e-10 NA NA NA hsa-miR-15a-5p PRKAA1 0.349521211668244 0.000770735998804736 -0.60864021207068 5.26267892833978e-12 MirTarget -0.127934215917556 0.00259652352236475 NA NA NA hsa-let-7b-3p PRKAA2 -1.21979213547786 5.84575581584603e-17 0.910177606708893 0.0133266185680845 mirMAP -0.385703556647416 0.00114946510675726 NA NA NA hsa-let-7b-5p PRKAA2 -0.959013717270803 5.95127281258643e-11 0.910177606708893 0.0133266185680845 miRNAWalker2_validate;MirTarget -0.399590032732691 0.000857606952583238 NA NA NA hsa-let-7c-5p PRKAA2 -1.70744661345097 2.87934212005942e-20 0.910177606708893 0.0133266185680845 MirTarget -0.323478962357034 0.000457014156060023 NA NA NA hsa-miR-125b-5p PRKAA2 -1.35767721102906 1.16564617395164e-18 0.910177606708893 0.0133266185680845 miRNATAP -0.468131740207186 2.58447444857568e-05 NA NA NA hsa-miR-126-5p PRKAA2 -0.428561469405594 6.6035585844222e-05 0.910177606708893 0.0133266185680845 mirMAP -0.353829124273961 0.0349255565875956 NA NA NA hsa-miR-130a-3p PRKAA2 -1.53229181736223 2.91460363624872e-19 0.910177606708893 0.0133266185680845 MirTarget -0.261650172386151 0.00937218581418371 NA NA NA hsa-miR-130b-3p PRKAA2 0.687190305027546 0.000109068658562255 0.910177606708893 0.0133266185680845 MirTarget -0.39214943725483 8.93727722972995e-05 NA NA NA hsa-miR-139-5p PRKAA2 -2.11299531796557 8.16407076415038e-28 0.910177606708893 0.0133266185680845 mirMAP -0.243840459298225 0.00500077362975578 NA NA NA hsa-miR-144-3p PRKAA2 -2.97536914478815 6.00546047309683e-28 0.910177606708893 0.0133266185680845 mirMAP -0.251212728741441 4.29127796324217e-05 NA NA NA hsa-miR-16-2-3p PRKAA2 -0.0336420826463706 0.805158952566973 0.910177606708893 0.0133266185680845 mirMAP -0.457570769127741 0.000536483503983079 NA NA NA hsa-miR-195-3p PRKAA2 -1.09375690196245 4.70092324819807e-09 0.910177606708893 0.0133266185680845 mirMAP -0.528536254111941 2.17986726272341e-08 NA NA NA hsa-miR-203a-3p PRKAA2 -1.34362479226226 8.69374456831293e-05 0.910177606708893 0.0133266185680845 MirTarget -0.179382015471783 0.000540688920660811 NA NA NA hsa-miR-217 PRKAA2 1.05797297540381 0.0401026692682422 0.910177606708893 0.0133266185680845 mirMAP -0.174781811555677 3.64856315207684e-07 NA NA NA hsa-miR-22-5p PRKAA2 -0.630365901263172 3.32415348030414e-05 0.910177606708893 0.0133266185680845 mirMAP -0.407034919675641 0.000519823954254811 NA NA NA hsa-miR-26a-5p PRKAA2 -0.963792031426845 1.83360999387345e-22 0.910177606708893 0.0133266185680845 mirMAP -0.782511241662933 5.79168652076068e-06 NA NA NA hsa-miR-30e-3p PRKAA2 -1.20845647373031 3.10263633528203e-25 0.910177606708893 0.0133266185680845 MirTarget -0.527801395071765 0.000287963362506242 NA NA NA hsa-miR-30e-5p PRKAA2 -0.627815042856657 3.02205690184908e-10 0.910177606708893 0.0133266185680845 MirTarget -0.438345582649116 0.0139749918956882 NA NA NA hsa-miR-576-5p PRKAA2 -0.377452008285847 0.00470735657343984 0.910177606708893 0.0133266185680845 mirMAP -0.339109435921254 0.0119064555477781 NA NA NA hsa-miR-628-3p PRKAA2 -0.958478775877672 6.18965095549213e-08 0.910177606708893 0.0133266185680845 mirMAP -0.30159363325766 0.00298084973196401 NA NA NA hsa-miR-181b-5p PRKAG2 0.488256489401108 0.00105321129419701 -1.10180393486939 5.09146502361984e-14 miRNATAP -0.425871154369953 1.72572702795849e-19 NA NA NA hsa-miR-181b-5p PRKCA 0.488256489401108 0.00105321129419701 0.662827897377551 1.5305893364122e-08 mirMAP -0.205095445188407 8.90870928470555e-08 NA NA NA hsa-miR-181b-5p PROX1 0.488256489401108 0.00105321129419701 -1.50692887128896 6.55353144337011e-08 MirTarget;miRNATAP -0.246977112719661 0.00760607606347608 NA NA NA hsa-miR-181b-5p PRRG1 0.488256489401108 0.00105321129419701 -0.908192707084856 3.41333706973093e-12 mirMAP -0.222221738806921 2.7162951837363e-07 NA NA NA hsa-miR-181b-5p PSD3 0.488256489401108 0.00105321129419701 -1.20252145080477 1.19868322011977e-09 mirMAP -0.461162772149117 6.63323598690523e-13 NA NA NA hsa-miR-181b-5p PSMA5 0.488256489401108 0.00105321129419701 -0.000190781838072418 0.998363086048208 mirMAP -0.144187844601641 1.4371657957329e-06 NA NA NA hsa-miR-181b-5p PTEN 0.488256489401108 0.00105321129419701 -0.546254680094508 2.77576587245444e-08 miRNAWalker2_validate;MirTarget;miRNATAP -0.114085044640472 0.000438213061284522 NA NA NA hsa-miR-181b-5p RAB11FIP2 0.488256489401108 0.00105321129419701 0.0463066186430496 0.661781012741478 mirMAP;miRNATAP -0.152200762243869 8.36787296373822e-06 NA NA NA hsa-miR-181b-5p RAD23B 0.488256489401108 0.00105321129419701 -0.349483835523183 2.52871873211643e-06 MirTarget -0.163805029928495 6.0022065657963e-12 NA NA NA hsa-miR-181b-5p REPS2 0.488256489401108 0.00105321129419701 -1.10574349357584 1.56638093233755e-10 MirTarget -0.342323944020876 1.55453234963799e-09 NA NA NA hsa-miR-181b-5p RHBDL3 0.488256489401108 0.00105321129419701 1.4613952794321 0.000215161782120482 mirMAP -0.384951896769435 0.00300269176000599 NA NA NA hsa-miR-542-3p RHEB -1.31351015149842 3.64642423288576e-22 0.594343190335174 8.4076096236034e-15 miRanda -0.154397416399753 5.84623305682461e-09 NA NA NA hsa-miR-140-3p RICTOR 0.546012239205329 4.84578261098777e-11 -0.237765548278541 0.0047022112792698 MirTarget;PITA;miRNATAP -0.120225620055793 0.014083109922705 NA NA NA hsa-miR-16-1-3p RICTOR 0.392360028038559 0.00112481918108198 -0.237765548278541 0.0047022112792698 MirTarget -0.107553049046612 0.00155488864096036 NA NA NA hsa-miR-660-5p RICTOR 0.989755850734071 5.69930767464937e-14 -0.237765548278541 0.0047022112792698 MirTarget -0.124145467768421 3.66585982170959e-05 NA NA NA hsa-miR-181b-5p RLF 0.488256489401108 0.00105321129419701 -0.463388101192929 2.9649077154719e-06 MirTarget;miRNATAP -0.103563311867167 0.00148433212129687 NA NA NA hsa-miR-181b-5p RMND5A 0.488256489401108 0.00105321129419701 -0.492348577397466 7.84892428586817e-07 mirMAP;miRNATAP -0.222093130430039 4.46243719964206e-12 NA NA NA hsa-miR-181b-5p RNF152 0.488256489401108 0.00105321129419701 -1.99846276106589 3.29375349002461e-27 mirMAP -0.211845675699934 0.00100162879022217 NA NA NA hsa-miR-181b-5p RNF6 0.488256489401108 0.00105321129419701 -0.192650958603799 0.0356267381099909 MirTarget;miRNATAP -0.106449094309103 0.000346893951393536 NA NA NA hsa-miR-181b-5p RORA 0.488256489401108 0.00105321129419701 -1.18591701647076 1.08163415927424e-11 MirTarget;miRNATAP -0.491703841118883 1.83302263910487e-18 NA NA NA hsa-miR-181b-5p RPAP2 0.488256489401108 0.00105321129419701 0.13738462327106 0.0752970261527869 MirTarget -0.100204176075283 5.92381497576948e-05 NA NA NA hsa-miR-99a-5p RPS6 -1.51481656384839 3.93230057259529e-14 0.185885010447493 0.120916808338817 miRNAWalker2_validate -0.141086052819295 4.22214050226356e-07 NA NA NA hsa-miR-17-5p RPS6KA1 0.698861147045461 2.43854106455398e-05 -0.0193982843076919 0.895272926505225 TargetScan;miRNATAP -0.150479492101603 0.000442310908893647 NA NA NA hsa-miR-20a-5p RPS6KA1 0.854326758727003 5.04256669663285e-07 -0.0193982843076919 0.895272926505225 miRNATAP -0.140420093444226 0.000724052018701145 NA NA NA hsa-miR-130b-5p RPS6KA2 0.170599813152408 0.337611586432771 -0.429936688183553 0.00940192295734202 mirMAP -0.213305958673466 2.2886761501014e-06 NA NA NA hsa-miR-17-5p RPS6KA2 0.698861147045461 2.43854106455398e-05 -0.429936688183553 0.00940192295734202 TargetScan -0.361293542462631 1.51868565926867e-14 NA NA NA hsa-miR-192-3p RPS6KA2 -0.6401165114007 0.000266272092403814 -0.429936688183553 0.00940192295734202 mirMAP -0.190995022600123 2.73504188366536e-05 NA NA NA hsa-miR-193a-3p RPS6KA2 -0.117675551589896 0.309391958208578 -0.429936688183553 0.00940192295734202 mirMAP -0.302358304666807 1.53272294304117e-05 NA NA NA hsa-miR-19a-3p RPS6KA2 1.01712596153672 2.57753201450625e-07 -0.429936688183553 0.00940192295734202 MirTarget -0.190446066307176 1.94564659739969e-06 NA NA NA hsa-miR-19b-3p RPS6KA2 0.601279551368824 0.00016685097085251 -0.429936688183553 0.00940192295734202 MirTarget -0.235922153431053 2.30069900396003e-06 NA NA NA hsa-miR-30d-5p RPS6KA2 0.718283816348023 2.47422074061352e-08 -0.429936688183553 0.00940192295734202 MirTarget;miRNATAP -0.222191844967225 0.000323873436695374 NA NA NA hsa-miR-3127-5p RPS6KA2 0.837385386388614 2.06679743975142e-07 -0.429936688183553 0.00940192295734202 mirMAP -0.204709957034024 3.28185871635773e-05 NA NA NA hsa-miR-532-3p RPS6KA2 0.297601533259956 0.014632205884815 -0.429936688183553 0.00940192295734202 MirTarget;mirMAP -0.296357914442727 7.3133532891582e-06 NA NA NA hsa-miR-589-5p RPS6KA2 1.18593770505086 1.01781241960531e-22 -0.429936688183553 0.00940192295734202 mirMAP -0.412829583412935 3.43368368308291e-11 NA NA NA hsa-miR-93-3p RPS6KA2 0.402821129107592 0.00131324842735588 -0.429936688183553 0.00940192295734202 MirTarget -0.482383363283909 1.2839051401815e-14 NA NA NA hsa-miR-181c-5p RPS6KA3 -0.00639394152050299 0.969127212255928 -0.0721830047612428 0.620235959053163 MirTarget;mirMAP;miRNATAP -0.132982978659169 0.00196775794236537 NA NA NA hsa-miR-497-5p RPS6KA3 -1.41371173021948 7.09278946477743e-17 -0.0721830047612428 0.620235959053163 MirTarget;miRNATAP -0.106167734324023 0.00837538561255109 NA NA NA hsa-miR-126-5p RPS6KB1 -0.428561469405594 6.6035585844222e-05 0.0405513114293425 0.579068505304799 mirMAP -0.106946073918378 0.00114467289374143 NA NA NA hsa-miR-145-5p RPS6KB1 -1.4795885711477 6.47308361543414e-16 0.0405513114293425 0.579068505304799 MirTarget;miRNATAP -0.109724019103871 2.07298188703538e-09 24157791 MiR 145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1; MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3'UTRs; Importantly the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145 respectively; Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1 functioning as a tumor suppressor ovarian cancer hsa-miR-181a-5p RPS6KB1 0.250113435902954 0.0551933249319293 0.0405513114293425 0.579068505304799 MirTarget;miRNATAP -0.116671963226395 1.5972465565874e-05 NA NA NA hsa-miR-181c-5p RPS6KB1 -0.00639394152050299 0.969127212255928 0.0405513114293425 0.579068505304799 MirTarget;miRNATAP -0.10835890138279 3.360156885851e-07 NA NA NA hsa-miR-27a-3p RPS6KB1 -0.370807380415112 0.00875721956202713 0.0405513114293425 0.579068505304799 MirTarget;miRNATAP -0.13716383977936 2.72226167197111e-08 NA NA NA hsa-miR-342-3p RPS6KB1 -0.319677314984262 0.0449813878317147 0.0405513114293425 0.579068505304799 miRanda -0.115090266357129 1.55784431831661e-07 NA NA NA hsa-miR-542-3p RPS6KB1 -1.31351015149842 3.64642423288576e-22 0.0405513114293425 0.579068505304799 miRNATAP -0.102388373747613 3.28524227017976e-05 NA NA NA hsa-miR-125a-5p RPS6KB2 -0.91219969372382 1.38256246489548e-07 0.230775242252044 0.00570601482278892 miRanda -0.115997614156545 4.04919339586598e-07 NA NA NA hsa-miR-181b-5p RSPO2 0.488256489401108 0.00105321129419701 -1.47503442551075 0.000466618278395286 MirTarget;miRNATAP -0.876393534278742 1.04924147416766e-10 NA NA NA hsa-miR-181b-5p S1PR1 0.488256489401108 0.00105321129419701 -0.723869489322336 1.31811287279409e-06 MirTarget;miRNATAP -0.125397523699022 0.0112069870070847 NA NA NA hsa-miR-181b-5p SAMD4A 0.488256489401108 0.00105321129419701 -0.955832382695032 2.80164696716111e-12 mirMAP -0.190362800605672 2.94161710437205e-05 NA NA NA hsa-miR-181b-5p SAMHD1 0.488256489401108 0.00105321129419701 -0.219855252528804 0.21059107396466 MirTarget -0.150110622113537 0.00877780794121613 NA NA NA hsa-miR-181b-5p SCAPER 0.488256489401108 0.00105321129419701 -0.367310646015773 0.0010383460763398 MirTarget -0.17761383169174 9.88648887939431e-07 NA NA NA hsa-miR-181b-5p SDC2 0.488256489401108 0.00105321129419701 -0.03087902282995 0.814769949243076 mirMAP -0.241361491882874 1.12082335235507e-08 NA NA NA hsa-miR-181b-5p SEC24A 0.488256489401108 0.00105321129419701 -0.591377269954405 1.3877848945236e-07 MirTarget;miRNATAP -0.23030008520952 2.5330299117093e-10 NA NA NA hsa-miR-181b-5p SEC62 0.488256489401108 0.00105321129419701 -0.921906590113964 6.87913526550551e-31 mirMAP -0.157570327188149 1.08289043000584e-08 NA NA NA hsa-miR-181b-5p SEL1L 0.488256489401108 0.00105321129419701 -0.497073293564348 3.72339072858383e-06 mirMAP;miRNATAP -0.170535383069273 1.13358785386084e-06 NA NA NA hsa-miR-181b-5p SELE 0.488256489401108 0.00105321129419701 -2.35025100185437 3.2370278829201e-13 MirTarget -0.23572975251646 0.0301557195284176 NA NA NA hsa-miR-181b-5p SEMA3B 0.488256489401108 0.00105321129419701 0.668562390600306 0.0188042749690616 MirTarget -0.234528312696168 0.011801454635489 NA NA NA hsa-miR-181b-5p SESN3 0.488256489401108 0.00105321129419701 -0.821541570789657 0.00383798636487833 MirTarget -0.324236880289917 0.00047836521786657 NA NA NA hsa-miR-181b-5p SFMBT1 0.488256489401108 0.00105321129419701 -0.127597815189636 0.161968044655003 MirTarget;miRNATAP -0.138926235179052 2.29177066830722e-06 NA NA NA hsa-miR-181b-5p SIK3 0.488256489401108 0.00105321129419701 -0.558299327637913 1.91997192491462e-09 MirTarget -0.109919569927828 0.000351491748797864 NA NA NA hsa-miR-181b-5p SIRT1 0.488256489401108 0.00105321129419701 -0.851284120733399 2.9344741272993e-11 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.165616125888402 0.000100128448749756 NA NA NA hsa-miR-181b-5p SLAIN2 0.488256489401108 0.00105321129419701 -0.37865756950093 8.79283914288049e-08 MirTarget -0.122297396502063 1.08434431919206e-07 NA NA NA hsa-miR-181b-5p SLC19A2 0.488256489401108 0.00105321129419701 -0.593493725054049 5.01535540839479e-05 MirTarget -0.239459091461628 4.92960361161557e-07 NA NA NA hsa-miR-181b-5p SLC22A3 0.488256489401108 0.00105321129419701 -1.9854213857181 3.33178978711179e-12 mirMAP -0.664246012711787 1.04662788141655e-12 NA NA NA hsa-miR-181b-5p SLC23A2 0.488256489401108 0.00105321129419701 -0.584703803315866 0.0010236404080005 mirMAP -0.367598727245575 1.32097607325811e-10 NA NA NA hsa-miR-181b-5p SLC25A25 0.488256489401108 0.00105321129419701 -1.10505911433835 5.5242474077183e-09 MirTarget;miRNATAP -0.321583489702475 2.43987828502607e-07 NA NA NA hsa-miR-181b-5p SLC25A37 0.488256489401108 0.00105321129419701 -0.718161877117594 9.11526444419931e-09 MirTarget -0.141914780762832 0.000601857836063652 NA NA NA hsa-miR-181b-5p SLC35A3 0.488256489401108 0.00105321129419701 -0.547853260400994 1.47231547250532e-05 mirMAP -0.342844443804445 1.06116211779551e-17 NA NA NA hsa-miR-181b-5p SLC35B4 0.488256489401108 0.00105321129419701 0.122330329859142 0.249678861953627 mirMAP -0.251940105869368 6.32976936802863e-14 NA NA NA hsa-miR-181b-5p SLC38A11 0.488256489401108 0.00105321129419701 -0.145549128486136 0.574613575913413 MirTarget -0.179242563421328 0.0343258881566124 NA NA NA hsa-miR-181b-5p SLC38A2 0.488256489401108 0.00105321129419701 -1.71612155888541 1.01671436925464e-27 mirMAP;miRNATAP -0.363854669515172 1.20634773577144e-11 NA NA NA hsa-miR-181b-5p SLC4A4 0.488256489401108 0.00105321129419701 -2.23317622565422 7.81779722860372e-13 mirMAP -0.804332139642516 2.11703095887466e-15 NA NA NA hsa-miR-181b-5p SLC5A3 0.488256489401108 0.00105321129419701 -1.14202730091157 9.93875965261116e-13 mirMAP -0.110059111313844 0.040998732942814 NA NA NA hsa-miR-181b-5p SLC7A2 0.488256489401108 0.00105321129419701 -2.401238445104 3.47302530727145e-22 MirTarget -0.344476706283616 4.98763727551343e-05 NA NA NA hsa-miR-181b-5p SLC9A6 0.488256489401108 0.00105321129419701 0.354720189606656 3.82887675091218e-05 miRNATAP -0.133438886851361 1.85957769801553e-06 NA NA NA hsa-miR-181b-5p SNX1 0.488256489401108 0.00105321129419701 -0.199729686068656 0.00561090290533367 mirMAP -0.117503478896254 4.11444800763771e-07 NA NA NA hsa-miR-181b-5p SOX5 0.488256489401108 0.00105321129419701 -1.35870465626211 3.34572839723252e-09 miRNATAP -0.327867585217995 1.58088921796821e-05 NA NA NA hsa-miR-181b-5p SPAG9 0.488256489401108 0.00105321129419701 -0.425454130288859 8.56735152376549e-07 mirMAP;miRNATAP -0.160978497530553 9.328769869473e-09 NA NA NA hsa-miR-181b-5p SS18L1 0.488256489401108 0.00105321129419701 -0.296492401776284 0.0220761965048876 miRNATAP -0.444233671193941 1.94729781151765e-29 NA NA NA hsa-miR-181b-5p SSX2IP 0.488256489401108 0.00105321129419701 0.284146878517911 0.111114755854163 MirTarget;mirMAP;miRNATAP -0.42597272142725 4.78310754424482e-14 NA NA NA hsa-miR-181b-5p STARD4 0.488256489401108 0.00105321129419701 -0.696471447741415 3.61296761564288e-05 MirTarget;mirMAP -0.160338629134663 0.00383257436144798 NA NA NA hsa-miR-140-5p STRADA -0.220106443070144 0.0140713197101242 0.498302253980222 3.82764636239296e-12 miRanda -0.120688525055184 0.00273933234610203 NA NA NA hsa-miR-542-3p STRADA -1.31351015149842 3.64642423288576e-22 0.498302253980222 3.82764636239296e-12 miRanda -0.17474859665732 8.10925851097995e-13 NA NA NA hsa-miR-181b-5p STX12 0.488256489401108 0.00105321129419701 -0.319661166824595 7.73724696997829e-07 mirMAP -0.134497094728664 9.82755217672181e-11 NA NA NA hsa-miR-181b-5p SUCLG2 0.488256489401108 0.00105321129419701 -1.20459027018039 2.73963638862473e-20 MirTarget -0.353267035180522 2.54271032479074e-16 NA NA NA hsa-miR-181b-5p SYAP1 0.488256489401108 0.00105321129419701 -0.463033190243062 1.43154636189129e-07 mirMAP -0.138657851610453 1.44132296636033e-06 NA NA NA hsa-miR-181b-5p SYPL2 0.488256489401108 0.00105321129419701 -1.08471212520328 0.00118696926904982 miRNATAP -0.724989120687629 1.42076309013101e-11 NA NA NA hsa-miR-181b-5p SYTL4 0.488256489401108 0.00105321129419701 -0.551448149757261 0.00433260079085029 mirMAP -0.508639223388709 7.61521375975593e-17 NA NA NA hsa-miR-181b-5p TADA1 0.488256489401108 0.00105321129419701 0.15524977247706 0.185752192849939 MirTarget -0.121072709059908 0.00150232332095873 NA NA NA hsa-miR-181b-5p TAF9B 0.488256489401108 0.00105321129419701 0.0168533538417588 0.873237203791974 MirTarget -0.171462062907383 4.47826170178778e-07 NA NA NA hsa-miR-181b-5p TBC1D15 0.488256489401108 0.00105321129419701 -0.632204764840025 2.42607131989069e-23 mirMAP -0.148824312091371 2.43001286802105e-12 NA NA NA hsa-miR-181b-5p TBL1X 0.488256489401108 0.00105321129419701 -0.210527078758218 0.0538137802227018 MirTarget;miRNATAP -0.174048839194183 7.72788457911812e-07 NA NA NA hsa-miR-181b-5p TEAD1 0.488256489401108 0.00105321129419701 -0.19170590497895 0.104550839525967 mirMAP;miRNATAP -0.118713199926625 0.00200784391763121 NA NA NA hsa-miR-181b-5p TEX2 0.488256489401108 0.00105321129419701 -0.48823499308155 2.16745539140888e-07 MirTarget -0.11796264024551 0.000138251173876437 NA NA NA hsa-miR-181b-5p TGFBR3 0.488256489401108 0.00105321129419701 -1.53475612080717 2.32211754233392e-15 mirMAP -0.467119604365662 2.30736536364399e-13 NA NA NA hsa-miR-181b-5p THRB 0.488256489401108 0.00105321129419701 -0.630015828817221 1.00813020178641e-06 MirTarget;mirMAP;miRNATAP -0.305643512648483 1.46230834503942e-13 NA NA NA hsa-miR-181b-5p TIMM17A 0.488256489401108 0.00105321129419701 0.343890553338641 0.00122865755696632 MirTarget -0.23910385814719 1.86850502424537e-12 NA NA NA hsa-miR-181b-5p TIMP3 0.488256489401108 0.00105321129419701 -0.479569227754572 0.00042274706056242 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.118880966586347 0.0077111895916643 27383203 Moreover miR-181b was found to directly target the 3' untranslated region 3'UTR of Timp3 mRNA affecting TGF-β-induced EMT gastric cancer hsa-miR-181b-5p TK2 0.488256489401108 0.00105321129419701 -0.656683086732082 2.72821191142893e-11 mirMAP -0.301318580097334 5.82160181162102e-22 NA NA NA hsa-miR-181b-5p TMCC1 0.488256489401108 0.00105321129419701 -0.104762238614036 0.46647436251659 mirMAP;miRNATAP -0.251994888501966 5.02351949914989e-08 NA NA NA hsa-miR-181b-5p TMED5 0.488256489401108 0.00105321129419701 -0.33764879066855 0.00113254692388959 mirMAP -0.24657000908633 7.45058709754898e-14 NA NA NA hsa-miR-181b-5p TMED7 0.488256489401108 0.00105321129419701 -0.253890513639785 0.00735487003225511 miRNAWalker2_validate;miRTarBase -0.178569554619496 4.28085055040639e-09 NA NA NA hsa-miR-181b-5p TMEM106B 0.488256489401108 0.00105321129419701 -0.291338163502867 0.00199329874426925 MirTarget -0.112535458370346 0.000243891977534774 NA NA NA hsa-miR-181b-5p TMEM184C 0.488256489401108 0.00105321129419701 -0.460467378541431 2.71070148754944e-06 MirTarget -0.123940295368149 0.00011670095304155 NA NA NA hsa-miR-181b-5p TMEM27 0.488256489401108 0.00105321129419701 -3.84360762472743 4.36959572638835e-30 MirTarget -0.618777407565115 1.28360332681645e-07 NA NA NA hsa-miR-181b-5p TMEM47 0.488256489401108 0.00105321129419701 -1.6215856228956 1.26274970190329e-13 mirMAP -0.347860959288199 1.89046385251935e-06 NA NA NA hsa-miR-181b-5p TMEM56 0.488256489401108 0.00105321129419701 -1.75634225549522 4.44536598470124e-19 mirMAP -0.609294513803451 1.69608415469662e-21 NA NA NA hsa-miR-181b-5p TMEM64 0.488256489401108 0.00105321129419701 -0.00136604960589803 0.993609309009731 MirTarget -0.284246377533529 2.26908648016544e-07 NA NA NA hsa-miR-181b-5p TMLHE 0.488256489401108 0.00105321129419701 -0.601175322962394 3.92895521860534e-10 MirTarget -0.212770502245822 9.38032392376128e-12 NA NA NA hsa-miR-181b-5p TNFAIP1 0.488256489401108 0.00105321129419701 -0.25456481631844 0.00166535803744622 MirTarget -0.197231007931395 1.35814831277352e-14 NA NA NA hsa-miR-181b-5p TOM1L1 0.488256489401108 0.00105321129419701 -0.380676699923202 0.00715427307906511 MirTarget -0.365891847865727 2.60556506054188e-16 NA NA NA hsa-miR-181b-5p TOR1AIP2 0.488256489401108 0.00105321129419701 -0.337836449293359 0.0591267564574758 MirTarget -0.217006366520003 0.000193357831475857 NA NA NA hsa-miR-181b-5p TRANK1 0.488256489401108 0.00105321129419701 -1.15202311428733 6.18978510841254e-14 miRNATAP -0.218942723452318 2.01637324610088e-05 NA NA NA hsa-miR-181b-5p TRIM2 0.488256489401108 0.00105321129419701 -0.669569001903942 0.000204730952595103 miRNATAP -0.320204860240171 4.27516868705967e-08 NA NA NA hsa-miR-181b-5p TRIM23 0.488256489401108 0.00105321129419701 -0.298910242960821 0.000941811896082851 mirMAP -0.216531365304488 4.3635143453713e-14 NA NA NA hsa-miR-181b-5p TRIM35 0.488256489401108 0.00105321129419701 -0.908312943568019 1.50923347465387e-09 mirMAP -0.353586132758614 3.81031711319792e-13 NA NA NA hsa-miR-10a-5p TSC1 -1.47723516092033 7.27299669108673e-16 0.920881916944059 1.33648384372723e-19 mirMAP -0.139629452664737 2.24435503048579e-07 NA NA NA hsa-miR-139-5p TSC1 -2.11299531796557 8.16407076415038e-28 0.920881916944059 1.33648384372723e-19 mirMAP -0.138969507847749 1.79604322012115e-08 NA NA NA hsa-miR-142-3p TSC1 -1.4243101967815 1.92609481097765e-14 0.920881916944059 1.33648384372723e-19 miRanda -0.126618039733337 2.13468537583732e-06 NA NA NA hsa-miR-195-3p TSC1 -1.09375690196245 4.70092324819807e-09 0.920881916944059 1.33648384372723e-19 mirMAP -0.102350213332177 0.000197504018678128 NA NA NA hsa-miR-23a-3p TSC1 -0.178875974460574 0.135978273540604 0.920881916944059 1.33648384372723e-19 mirMAP -0.10311318429677 0.0177752417141775 NA NA NA hsa-miR-335-5p TSC1 -1.61347836513558 1.62757083289711e-19 0.920881916944059 1.33648384372723e-19 miRNAWalker2_validate -0.127585694708462 3.44981987359883e-06 NA NA NA hsa-miR-3614-5p TSC1 -1.66311416965679 1.26647181860439e-15 0.920881916944059 1.33648384372723e-19 mirMAP -0.106465716187074 1.0480173495806e-05 NA NA NA hsa-miR-450b-5p TSC1 -1.34333360369432 2.68386079790462e-17 0.920881916944059 1.33648384372723e-19 mirMAP -0.130360378995634 2.9321967866797e-05 NA NA NA hsa-miR-542-3p TSC1 -1.31351015149842 3.64642423288576e-22 0.920881916944059 1.33648384372723e-19 PITA;miRanda -0.198207156237058 3.1659040994906e-08 NA NA NA hsa-miR-744-5p TSC2 -0.378868377317939 0.00125071229180016 0.454638169130336 1.34709422274577e-05 miRNAWalker2_validate -0.146650115106937 0.000784576818042153 NA NA NA hsa-miR-181b-5p TSC22D2 0.488256489401108 0.00105321129419701 -1.12090763359319 2.22265538164126e-16 MirTarget -0.196034968115083 1.99198917257437e-05 NA NA NA hsa-miR-181b-5p TTBK1 0.488256489401108 0.00105321129419701 -0.828139372024007 0.00392617205238364 miRNATAP -0.298968230844976 0.00145777554039975 NA NA NA hsa-miR-181b-5p TTC39B 0.488256489401108 0.00105321129419701 -1.71973555703333 1.52777146203724e-14 MirTarget;miRNATAP -0.345269823928293 4.03390575882277e-06 NA NA NA hsa-miR-181b-5p TTLL7 0.488256489401108 0.00105321129419701 -0.174209860799301 0.581064288483948 MirTarget -0.367587805517535 0.000340744906703221 NA NA NA hsa-miR-181b-5p TXNL1 0.488256489401108 0.00105321129419701 0.0602068041488337 0.485867472102786 mirMAP -0.115923810113945 3.21073234136468e-05 NA NA NA hsa-miR-181b-5p UBB 0.488256489401108 0.00105321129419701 -0.538601985573999 4.76332158900571e-08 miRNAWalker2_validate -0.194003959275969 1.4466728714083e-09 NA NA NA hsa-miR-181b-5p UBE2B 0.488256489401108 0.00105321129419701 -0.102784203823933 0.199378542308151 MirTarget -0.106595210940937 3.72368496090919e-05 NA NA NA hsa-miR-181b-5p UBE2D3 0.488256489401108 0.00105321129419701 -0.546454726317387 9.53324910574043e-17 MirTarget;mirMAP -0.120445731017042 3.57692975825359e-08 NA NA NA hsa-miR-181b-5p UBE3C 0.488256489401108 0.00105321129419701 0.0110137435810636 0.905807612215828 MirTarget;miRNATAP -0.10704614742396 0.000381756152235473 NA NA NA hsa-miR-181b-5p UBL3 0.488256489401108 0.00105321129419701 -0.852818064860432 1.70418663179437e-14 MirTarget;mirMAP;miRNATAP -0.214804374974692 5.5599788443542e-09 NA NA NA hsa-miR-181b-5p UBXN10 0.488256489401108 0.00105321129419701 -1.75060710944774 2.42078409774784e-06 mirMAP -1.27160835977865 1.41632635035813e-28 NA NA NA hsa-miR-181b-5p UHMK1 0.488256489401108 0.00105321129419701 -0.803204254827771 0.00347508080027661 mirMAP -0.197196051374925 0.0288087973265019 NA NA NA hsa-miR-10b-3p ULK2 2.77189254628215 2.26687582932628e-20 -0.751057335334513 0.00080135979131828 MirTarget -0.148313505499471 7.61598951514493e-05 NA NA NA hsa-miR-130b-3p ULK2 0.687190305027546 0.000109068658562255 -0.751057335334513 0.00080135979131828 MirTarget -0.255363263740498 2.88541774955778e-05 NA NA NA hsa-miR-361-5p ULK2 0.233202959858696 0.00961572812255327 -0.751057335334513 0.00080135979131828 miRanda;miRNATAP -0.280930943836965 0.0228686012556111 NA NA NA hsa-miR-181b-5p USP47 0.488256489401108 0.00105321129419701 -0.288927257048455 1.31798435018082e-05 mirMAP -0.104888390679363 1.04415800709323e-06 NA NA NA hsa-miR-150-5p VEGFA -1.14624309254329 1.51365525978726e-06 0.0263183839451075 0.81382635000524 miRNAWalker2_validate;miRTarBase -0.114666527453602 2.4663414134099e-07 NA NA NA hsa-miR-29b-2-5p VEGFA -0.223258653034772 0.084306146519938 0.0263183839451075 0.81382635000524 MirTarget -0.132006150652748 0.00171675395806506 NA NA NA hsa-miR-29b-3p VEGFA -0.348885528720517 0.0121441341291285 0.0263183839451075 0.81382635000524 miRNAWalker2_validate;miRTarBase;MirTarget -0.125790856471025 0.00126089778683366 26155940;22815235 Moreover miR-29b inhibits angiogenesis by attenuating tube formation and the expression of VEGF and Ang-2 and stemness maintenance in GBM cells as demonstrated by decreasing neurosphere formation and cancer stem cell marker protein expression;Additionally for two genes that are deregulated in PCa heterogeneous nuclear ribonucleoprotein K hnRNP-K and vascular endothelial growth factor A VEGF-A we identified two regulatory miRNAs miR-205 and miR-29b ; glioblastoma;prostate cancer hsa-miR-140-5p VEGFB -0.220106443070144 0.0140713197101242 0.0320278813662975 0.892480348417874 miRanda -0.268562632744809 0.0395419509098586 NA NA NA hsa-miR-128-3p VEGFC 0.289735108018712 0.0114419474207889 0.0031169028254141 0.982787493023474 miRNAWalker2_validate;MirTarget -0.198618366596319 0.00124097531466772 25001183;26722309 Interestingly ectopic miR-128 overexpression could significantly inhibit vascular endothelial growth factor VEGF-C expression and reduce the activity of a luciferase reporter containing the VEGF-C 3'-untranslated region; These findings suggest that miR-128 could play a role in NSCLC tumourigenesis at least in part by modulation of angiogenesis and lymphangiogenesis through targeting VEGF-C and could simultaneously block ERK AKT and p38 signalling pathways;miR 128 downregulation promotes growth and metastasis of bladder cancer cells and involves VEGF C upregulation; To investigate the regulation of miR-128 on VEGF-C expression and their effects on proliferation and metastasis of bladder cancer T24 and 5637 BC cells were transfected with pre-miR-128 anti-miR-128 and their respective negative control; miR-128 was downregulated in BC tissues and cell lines while the expression levels of VEGF-C were upregulated; The present results indicated that miR-128 negatively regulated VEGF-C expression in BC T24 and 5637 BC cells; VEGF-C is a direct target of miR-128 in BC cells ;metastasis lung squamous cell cancer;bladder cancer hsa-miR-16-2-3p VEGFC -0.0336420826463706 0.805158952566973 0.0031169028254141 0.982787493023474 MirTarget -0.149514000508957 0.00387572506927192 NA NA NA hsa-miR-374a-5p VEGFC 0.016390363747302 0.869784217438621 0.0031169028254141 0.982787493023474 MirTarget -0.28522635078723 5.53265846690998e-05 NA NA NA hsa-miR-374b-5p VEGFC -0.307538028546424 0.0030079617545972 0.0031169028254141 0.982787493023474 MirTarget -0.209454919974677 0.00209421071373184 NA NA NA hsa-miR-590-3p VEGFC -0.473167498047808 1.76652934637227e-05 0.0031169028254141 0.982787493023474 miRanda -0.274821384359749 1.36978001441178e-05 NA NA NA hsa-miR-181b-5p VPS36 0.488256489401108 0.00105321129419701 -0.567458160061146 1.90597492149183e-08 mirMAP -0.16210964164094 9.75256633910275e-07 NA NA NA hsa-miR-181b-5p VPS52 0.488256489401108 0.00105321129419701 0.349883435414734 2.09921089731539e-06 mirMAP -0.118562035576257 7.58482369308195e-07 NA NA NA hsa-miR-181b-5p VSNL1 0.488256489401108 0.00105321129419701 -0.874873254541304 0.0199688194916894 miRNAWalker2_validate;miRTarBase -0.542565101990497 8.83517963771935e-06 NA NA NA hsa-miR-181b-5p WASL 0.488256489401108 0.00105321129419701 -0.151210138994514 0.0497433874528767 MirTarget;miRNATAP -0.116039090843406 2.93502543332777e-06 NA NA NA hsa-miR-181b-5p WDR7 0.488256489401108 0.00105321129419701 -0.721226430814737 5.8107002873624e-15 mirMAP -0.215508760562926 1.17439975895588e-12 NA NA NA hsa-miR-181b-5p WNK3 0.488256489401108 0.00105321129419701 -0.836532944570787 0.00785592148273515 miRNATAP -0.549486690120314 6.57334699929943e-08 NA NA NA hsa-miR-181b-5p WWC2 0.488256489401108 0.00105321129419701 -0.895367958967769 3.36316136449853e-11 mirMAP -0.117743355113198 0.0090952729115219 NA NA NA hsa-miR-181b-5p XIAP 0.488256489401108 0.00105321129419701 -0.15308594423064 0.0753030128680062 miRNAWalker2_validate;miRTarBase;mirMAP -0.110373062475686 7.3789440913243e-05 NA NA NA hsa-miR-181b-5p XKR9 0.488256489401108 0.00105321129419701 -0.811781509743297 0.0361203049863371 mirMAP -0.52490902119526 3.05513325742417e-05 NA NA NA hsa-miR-181b-5p YIPF4 0.488256489401108 0.00105321129419701 -0.452912538074102 8.76433251729972e-10 mirMAP -0.115258425929666 2.01845212733732e-06 NA NA NA hsa-miR-181b-5p YIPF6 0.488256489401108 0.00105321129419701 -0.130504002208799 0.166772554218636 mirMAP -0.16287487763089 7.64833777625043e-08 NA NA NA hsa-miR-181b-5p YTHDC2 0.488256489401108 0.00105321129419701 -0.261868884098192 0.00522420617690561 MirTarget -0.116338635435983 0.000134061154737012 NA NA NA hsa-miR-181b-5p ZBED3 0.488256489401108 0.00105321129419701 0.219745258993966 0.213330166431833 mirMAP -0.126427968960632 0.0283549982223334 NA NA NA hsa-miR-181b-5p ZBTB20 0.488256489401108 0.00105321129419701 -0.721517199741877 6.05331504375829e-06 miRNAWalker2_validate -0.199630583842404 0.0001371165199711 NA NA NA hsa-miR-181b-5p ZC3H6 0.488256489401108 0.00105321129419701 -0.213328047752035 0.0574717114596243 miRNATAP -0.147413759142574 5.12832667274402e-05 NA NA NA hsa-miR-181b-5p ZCCHC2 0.488256489401108 0.00105321129419701 -0.958784652047301 6.66946185116509e-17 mirMAP -0.160715602763594 3.25137583319238e-05 NA NA NA hsa-miR-181b-5p ZFHX4 0.488256489401108 0.00105321129419701 -0.832628706674559 7.07667307978028e-05 MirTarget;mirMAP;miRNATAP -0.257656077878309 0.000174853767443786 NA NA NA hsa-miR-181b-5p ZFP36L1 0.488256489401108 0.00105321129419701 -1.16699812240509 1.50804518778222e-27 miRNATAP -0.132009668030417 0.000398170174799281 NA NA NA hsa-miR-181b-5p ZNF268 0.488256489401108 0.00105321129419701 -0.593152337415467 2.02863291106211e-05 MirTarget -0.10406262423761 0.0232743506727264 NA NA NA hsa-miR-181b-5p ZNF396 0.488256489401108 0.00105321129419701 0.253036000851592 0.0549603177822499 miRNATAP -0.196847105189002 3.92416278217083e-06 NA NA NA hsa-miR-181b-5p ZNF451 0.488256489401108 0.00105321129419701 0.00667997245057173 0.935667435375475 mirMAP -0.103631073127578 0.000105330048525823 NA NA NA hsa-miR-181b-5p ZNF503 0.488256489401108 0.00105321129419701 0.22587365787045 0.232944065367825 miRNAWalker2_validate -0.324352633058089 1.04751327918961e-07 NA NA NA hsa-miR-181b-5p ZNF563 0.488256489401108 0.00105321129419701 0.853469338413236 4.82981330058587e-08 MirTarget;miRNATAP -0.176860351950483 0.000625364727112428 NA NA NA hsa-miR-181b-5p ZNF654 0.488256489401108 0.00105321129419701 -0.621209689571205 1.69740975453914e-13 MirTarget -0.121792650181654 1.41505866216099e-05 NA NA NA hsa-miR-181b-5p ZNF747 0.488256489401108 0.00105321129419701 -0.335136007141183 0.000287797653513016 miRNAWalker2_validate -0.214005619442387 3.66641898151081e-13 NA NA NA hsa-miR-181b-5p ZNF75D 0.488256489401108 0.00105321129419701 0.00169595616856633 0.986510624932447 mirMAP -0.107799805001994 0.000918834207854721 NA NA NA hsa-miR-181b-5p ZNRF2 0.488256489401108 0.00105321129419701 -0.338839245711862 0.000542965090087702 MirTarget -0.205933710430854 5.34103000430317e-11 NA NA NA hsa-miR-181b-5p ZRANB1 0.488256489401108 0.00105321129419701 -0.533805690434926 1.19229356780518e-07 mirMAP -0.141102512602061 2.02135089502776e-05 NA NA NA