miRNA gene miRNA_log2FC miRNA_pvalue gene_log2FC gene_pvalue interactions correlation_beta correlation_pvalue PMID evidence outcome cancer hsa-miR-141-3p ABL1 5.02396127982626 2.19224509139725e-24 -1.32037015957096 1.87647767985755e-18 MirTarget -0.175107254317894 1.9871253927784e-40 NA NA NA hsa-miR-141-3p ABL2 5.02396127982626 2.19224509139725e-24 -0.318835189302919 0.0455399452105181 MirTarget;TargetScan;miRNATAP -0.134399536040292 8.02666476133273e-22 NA NA NA hsa-miR-141-3p ACO1 5.02396127982626 2.19224509139725e-24 -0.652500844012158 0.000553364482031078 MirTarget;TargetScan -0.130163835782654 1.98192362231869e-14 NA NA NA hsa-miR-141-3p ADARB1 5.02396127982626 2.19224509139725e-24 -1.92780468757935 3.75403498492562e-10 MirTarget -0.338475785952679 4.09008976936958e-37 NA NA NA hsa-miR-141-3p AFAP1 5.02396127982626 2.19224509139725e-24 -0.984844531728039 0.000121375966999112 mirMAP -0.240690375927166 6.02043219001966e-27 NA NA NA hsa-miR-141-3p AKAP2 5.02396127982626 2.19224509139725e-24 -2.50607126147978 8.18180385648383e-05 TargetScan -0.592451456526002 2.32091834867608e-26 NA NA NA hsa-miR-141-3p AMOTL1 5.02396127982626 2.19224509139725e-24 -1.62373117026861 1.24108045740137e-08 TargetScan -0.263915992858439 1.62622341145465e-25 NA NA NA hsa-miR-141-3p AMZ1 5.02396127982626 2.19224509139725e-24 0.478054987094894 0.336377469860163 mirMAP -0.170552638793477 0.000193440516792394 NA NA NA hsa-miR-141-3p ANGPTL1 5.02396127982626 2.19224509139725e-24 -4.51343158742721 1.32318310475559e-13 MirTarget -0.761705592149959 2.2939308448729e-49 NA NA NA hsa-miR-141-3p ANK2 5.02396127982626 2.19224509139725e-24 -4.31721795702785 2.30783903904989e-14 TargetScan;miRNATAP -0.683679141640631 3.18446904488388e-45 NA NA NA hsa-miR-141-3p ANKRD44 5.02396127982626 2.19224509139725e-24 -1.93020763162674 4.46055534768925e-08 TargetScan -0.345297858061492 7.15806905996816e-29 NA NA NA hsa-miR-141-3p ANO5 5.02396127982626 2.19224509139725e-24 -3.19214261632059 9.92014938597976e-09 mirMAP -0.298421469653444 7.41246753821778e-09 NA NA NA hsa-miR-141-3p APBB2 5.02396127982626 2.19224509139725e-24 -0.590550070945143 0.00139703077075369 MirTarget;TargetScan -0.16820450447715 2.14901507304753e-25 NA NA NA hsa-miR-141-3p APOLD1 5.02396127982626 2.19224509139725e-24 -2.61565377645349 1.36771501780805e-19 TargetScan -0.243706988784122 8.0918207579202e-20 NA NA NA hsa-miR-141-3p ARHGAP24 5.02396127982626 2.19224509139725e-24 -2.02152097141819 3.81745641239796e-10 TargetScan;miRNATAP -0.384112170664898 9.24234006817553e-45 NA NA NA hsa-miR-141-3p ARID5B 5.02396127982626 2.19224509139725e-24 -1.57471227678776 1.38880293146998e-13 TargetScan;miRNATAP -0.163570235555056 5.51748671636683e-17 NA NA NA hsa-miR-141-3p ARL10 5.02396127982626 2.19224509139725e-24 -1.12227531152641 0.00197533796722557 mirMAP -0.254180203960422 6.73994516307074e-15 NA NA NA hsa-miR-141-3p ARL4A 5.02396127982626 2.19224509139725e-24 -0.615829174715148 0.0152477484975196 TargetScan -0.102434904962628 1.12328062913009e-05 NA NA NA hsa-miR-141-3p ARNT2 5.02396127982626 2.19224509139725e-24 -1.45137144640546 0.000194389722909985 mirMAP -0.133475560455107 0.000218811297212122 NA NA NA hsa-miR-141-3p ARNTL 5.02396127982626 2.19224509139725e-24 -0.356733668497135 0.0895626680520666 MirTarget;TargetScan;miRNATAP -0.10408450992134 5.45135927978183e-08 NA NA NA hsa-miR-141-3p ASB1 5.02396127982626 2.19224509139725e-24 -0.87000981136547 1.63208206880833e-08 mirMAP -0.120167852143178 4.97494070976464e-18 NA NA NA hsa-miR-141-3p ASTN1 5.02396127982626 2.19224509139725e-24 -2.34091357321142 2.35607881846946e-05 MirTarget;miRNATAP -0.142422591927457 0.0058243112113976 NA NA NA hsa-miR-141-3p ASXL3 5.02396127982626 2.19224509139725e-24 -3.33764959592997 4.422152746114e-10 TargetScan -0.310308010322806 3.94264179759946e-10 NA NA NA hsa-miR-141-3p ATP8A1 5.02396127982626 2.19224509139725e-24 -1.47752118217688 7.63290299845151e-05 MirTarget;TargetScan -0.155539937806406 6.64664107398294e-06 NA NA NA hsa-miR-141-3p ATXN1 5.02396127982626 2.19224509139725e-24 -1.5104377454496 2.95939614593378e-08 MirTarget;TargetScan;miRNATAP -0.242034345827017 1.89337327751857e-23 NA NA NA hsa-miR-141-3p BACE1 5.02396127982626 2.19224509139725e-24 -0.723461241968299 0.00095792938893533 TargetScan;miRNATAP -0.219980230813457 2.13236282870747e-31 NA NA NA hsa-miR-141-3p BACH2 5.02396127982626 2.19224509139725e-24 -1.52271748612635 0.00133867288726185 TargetScan -0.485520358400061 1.24233512861177e-32 NA NA NA hsa-miR-210-3p BDNF 6.07079758655679 2.22120227133377e-28 -2.90846311399482 3.32327619207597e-11 miRNAWalker2_validate;miRTarBase -0.237223359082858 5.07246234320821e-11 NA NA NA hsa-miR-141-3p BEND4 5.02396127982626 2.19224509139725e-24 -1.96898871811517 7.28857253483474e-05 TargetScan;miRNATAP -0.289863184708252 1.6418670625527e-10 NA NA NA hsa-miR-141-3p BNC2 5.02396127982626 2.19224509139725e-24 -2.95176911794991 3.46014802400024e-09 TargetScan -0.634996328559649 3.99693205136847e-53 NA NA NA hsa-miR-141-3p BVES 5.02396127982626 2.19224509139725e-24 -2.76011138905276 3.72014251471103e-09 mirMAP -0.482117813782504 4.24689671402245e-32 NA NA NA hsa-miR-141-3p C11orf21 5.02396127982626 2.19224509139725e-24 -1.30848301714895 0.00226870309084665 mirMAP -0.239688766014697 8.64099216632011e-10 NA NA NA hsa-miR-141-3p CACNA2D1 5.02396127982626 2.19224509139725e-24 -3.31556565717047 8.68804644381516e-07 TargetScan -0.712756989651708 1.52663401986901e-34 NA NA NA hsa-miR-141-3p CADM1 5.02396127982626 2.19224509139725e-24 -1.1928516537365 0.0125125326037739 MirTarget;TargetScan -0.158377342012299 0.000330308063762073 NA NA NA hsa-miR-141-3p CADM2 5.02396127982626 2.19224509139725e-24 -3.83563052563186 2.24615008924082e-11 TargetScan;miRNATAP -0.296449332510535 3.20564005327105e-08 NA NA NA hsa-miR-141-3p CALU 5.02396127982626 2.19224509139725e-24 -0.148100201074846 0.463184247628706 TargetScan -0.195681214306377 1.90065013398411e-29 NA NA NA hsa-miR-141-3p CAMK4 5.02396127982626 2.19224509139725e-24 -1.28087531958322 0.00219906979140792 mirMAP -0.286889492770795 2.7215319426945e-14 NA NA NA hsa-miR-141-3p CCDC80 5.02396127982626 2.19224509139725e-24 -3.33072052510427 2.4668324543934e-10 MirTarget;TargetScan -0.693632636221427 5.46323443396302e-58 NA NA NA hsa-miR-141-3p CCND2 5.02396127982626 2.19224509139725e-24 -2.42747067684236 2.06814828958882e-10 MirTarget;TargetScan -0.336824974322951 8.46453268716016e-23 NA NA NA hsa-miR-141-3p CCPG1 5.02396127982626 2.19224509139725e-24 -1.00054342022822 9.35804943183486e-08 MirTarget;miRNATAP -0.187963297470156 1.21508136995256e-30 NA NA NA hsa-miR-141-3p CD274 5.02396127982626 2.19224509139725e-24 0.0610119269874347 0.90454084693838 MirTarget -0.219387383135692 2.45166085997734e-06 NA NA NA hsa-miR-141-3p CD59 5.02396127982626 2.19224509139725e-24 -0.701153559236412 0.00130409241528683 mirMAP -0.104731717796861 1.60748972337276e-07 NA NA NA hsa-miR-141-3p CDC25B 5.02396127982626 2.19224509139725e-24 0.783166040527924 0.00478680511553999 TargetScan -0.118085231335799 3.69707768792997e-06 NA NA NA hsa-miR-141-3p CDC42EP3 5.02396127982626 2.19224509139725e-24 -1.35474123311743 4.46611463922157e-07 MirTarget;TargetScan -0.222656011819807 1.75742899844836e-20 NA NA NA hsa-miR-141-3p CDK6 5.02396127982626 2.19224509139725e-24 -0.774202349805119 0.064787030605636 TargetScan;miRNATAP -0.280860480145549 9.29496321423746e-14 NA NA NA hsa-miR-141-3p CDON 5.02396127982626 2.19224509139725e-24 -2.61239140080419 3.20760880328893e-10 TargetScan;miRNATAP -0.399651490992396 1.87667057546839e-27 NA NA NA hsa-miR-141-3p CDV3 5.02396127982626 2.19224509139725e-24 -0.422762901340256 0.00210317952393349 TargetScan;miRNATAP -0.108062710883357 7.65468940912447e-19 NA NA NA hsa-miR-141-3p CELF2 5.02396127982626 2.19224509139725e-24 -3.04719737979328 4.72041352009215e-15 mirMAP;miRNATAP -0.468029455067076 1.44353494732578e-44 NA NA NA hsa-miR-141-3p CEP170 5.02396127982626 2.19224509139725e-24 -0.105046872769039 0.582677978132971 TargetScan -0.143778949230595 2.34588339926208e-17 NA NA NA hsa-miR-141-3p CFL2 5.02396127982626 2.19224509139725e-24 -2.61712932503392 6.6876672984936e-21 TargetScan -0.423079946720063 4.08147779181854e-80 NA NA NA hsa-miR-141-3p CHRDL1 5.02396127982626 2.19224509139725e-24 -6.14628787036669 1.26356425887682e-13 MirTarget;TargetScan -0.900396235275418 3.3629060237609e-35 NA NA NA hsa-miR-141-3p CLIC4 5.02396127982626 2.19224509139725e-24 -1.72389310060141 6.21382968572505e-08 MirTarget -0.404726937144751 1.2775065112373e-53 NA NA NA hsa-miR-141-3p CLIP2 5.02396127982626 2.19224509139725e-24 -0.796927760614636 0.00157984633892106 MirTarget;TargetScan -0.153053376466775 2.28983610764706e-11 NA NA NA hsa-miR-141-3p CNTN1 5.02396127982626 2.19224509139725e-24 -4.98280431564283 1.02293078354206e-09 MirTarget;TargetScan;miRNATAP -0.748169609710896 8.29284114896725e-25 NA NA NA hsa-miR-141-3p COL11A1 5.02396127982626 2.19224509139725e-24 4.68886927590747 2.15659824797734e-08 miRNATAP -0.226787669474765 0.00396629375366405 NA NA NA hsa-miR-141-3p COL15A1 5.02396127982626 2.19224509139725e-24 -0.944640457730359 0.00987813769171885 MirTarget -0.340716901256044 1.20518963821043e-26 NA NA NA hsa-miR-141-3p COL8A1 5.02396127982626 2.19224509139725e-24 -0.750287440568718 0.115004485468589 mirMAP -0.3753845013992 5.90933384363944e-19 NA NA NA hsa-miR-141-3p CORO1C 5.02396127982626 2.19224509139725e-24 -1.12142787999647 2.05016310243217e-07 TargetScan -0.247770057122117 7.60999610194092e-42 NA NA NA hsa-miR-210-3p CORO2B 6.07079758655679 2.22120227133377e-28 -2.02918310395295 2.78730592488677e-06 MirTarget -0.21933845970618 5.15126217245718e-10 NA NA NA hsa-miR-141-3p CPEB4 5.02396127982626 2.19224509139725e-24 -1.5612678794228 1.72557073170333e-13 TargetScan -0.12354401076053 4.29390485758248e-10 NA NA NA hsa-miR-141-3p CREB5 5.02396127982626 2.19224509139725e-24 -2.27679484644664 4.56595042875634e-09 mirMAP -0.412602227752003 1.82008564281382e-34 NA NA NA hsa-miR-141-3p CRMP1 5.02396127982626 2.19224509139725e-24 -1.10713929622082 0.00157678184529984 MirTarget;TargetScan -0.225882860206249 1.04462945549287e-12 NA NA NA hsa-miR-141-3p CSF3 5.02396127982626 2.19224509139725e-24 -4.55276205983688 3.03447416692714e-08 TargetScan;miRNATAP -0.537552891809218 9.56020415551903e-13 NA NA NA hsa-miR-141-3p CTSB 5.02396127982626 2.19224509139725e-24 0.103494529069311 0.676734042160374 mirMAP -0.17150568102485 1.12551008947305e-14 NA NA NA hsa-miR-141-3p CTTNBP2 5.02396127982626 2.19224509139725e-24 -2.89596279474146 5.90459907376795e-06 miRNATAP -0.236598863986591 6.89302999060296e-05 NA NA NA hsa-miR-141-3p CXCL12 5.02396127982626 2.19224509139725e-24 -3.25514460573678 2.71023256513876e-11 miRNATAP -0.581600485846245 1.98789449461909e-44 NA NA NA hsa-miR-141-3p CYLD 5.02396127982626 2.19224509139725e-24 -0.892927493541401 1.56901081849426e-07 mirMAP -0.139718374493641 4.72424398005685e-20 NA NA NA hsa-miR-141-3p CYP26B1 5.02396127982626 2.19224509139725e-24 -0.687056430058883 0.15191405383577 MirTarget;TargetScan;miRNATAP -0.379672308940082 4.02732278327878e-19 NA NA NA hsa-miR-141-3p DIO2 5.02396127982626 2.19224509139725e-24 -0.24250919408575 0.634536833282091 miRNATAP -0.293892171655239 1.99637530606769e-10 NA NA NA hsa-miR-141-3p DLC1 5.02396127982626 2.19224509139725e-24 -1.80446027708783 9.14505487509203e-10 TargetScan;miRNATAP -0.205743446999626 2.40423756136419e-14 26278151 MicroRNA 141 regulates the tumour suppressor DLC1 in colorectal cancer; Luciferase reporter assays and Western blots showed that DLC1 was a direct target of miR-141 in CRC; The expression levels of miR-141 were obviously up-regulated in CRC tissues compared to non-cancerous tissues while DLC1 expression levels were down-regulated in a high proportion of clinical samples 14/18; In addition correlation analyses revealed negative correlation between miR-141 levels and DLC1 expression levels in CRC tissues; In conclusion we demonstrated that miR-141 is up-regulated in CRC and acts as a functional oncogene by targeting DLC1 colorectal cancer hsa-miR-141-3p DOCK4 5.02396127982626 2.19224509139725e-24 -0.482456191440432 0.0791191956674349 MirTarget;TargetScan -0.182121730425507 1.6735288026444e-13 NA NA NA hsa-miR-141-3p DPYSL3 5.02396127982626 2.19224509139725e-24 -2.3174606683978 1.31913973979472e-07 TargetScan -0.538946381354509 4.38482185108261e-49 NA NA NA hsa-miR-141-3p DSEL 5.02396127982626 2.19224509139725e-24 -1.79437646323741 2.08106957836486e-07 TargetScan -0.293103774207814 2.27712643948802e-21 NA NA NA hsa-miR-141-3p DST 5.02396127982626 2.19224509139725e-24 -1.11542714896545 9.14769438027749e-05 mirMAP -0.122503310762156 3.24347958325919e-06 NA NA NA hsa-miR-141-3p DUSP1 5.02396127982626 2.19224509139725e-24 -3.47418646928724 1.98436002754553e-20 TargetScan -0.341619784247028 4.31538999884695e-23 NA NA NA hsa-miR-141-3p DUSP3 5.02396127982626 2.19224509139725e-24 -1.04472877082381 6.16231013810421e-12 MirTarget;TargetScan;miRNATAP -0.153679233077013 1.48438763140924e-30 NA NA NA hsa-miR-141-3p DYNC1I1 5.02396127982626 2.19224509139725e-24 -2.0457299899893 0.00010088277927843 MirTarget -0.213104292318958 1.19223595981888e-05 NA NA NA hsa-miR-141-3p DZIP1 5.02396127982626 2.19224509139725e-24 -1.57008196403815 1.8435672027566e-05 TargetScan;miRNATAP -0.293961254371322 2.97515506435194e-19 NA NA NA hsa-miR-141-3p EGR2 5.02396127982626 2.19224509139725e-24 -2.81415398238775 4.48213127682575e-11 TargetScan;miRNATAP -0.469632063005659 7.87492781791156e-37 NA NA NA hsa-miR-210-3p ELFN2 6.07079758655679 2.22120227133377e-28 -0.55577698273676 0.366123227740695 MirTarget -0.169371259234315 0.000762086167416835 NA NA NA hsa-miR-141-3p ELK3 5.02396127982626 2.19224509139725e-24 -0.31361161770499 0.256409444995651 TargetScan -0.186479252851037 5.30229855466226e-14 NA NA NA hsa-miR-141-3p ELL2 5.02396127982626 2.19224509139725e-24 -1.08408930026814 1.18240618311454e-05 TargetScan -0.132345567602773 5.72819500490292e-09 NA NA NA hsa-miR-141-3p ENAH 5.02396127982626 2.19224509139725e-24 -0.681669392071856 0.000630502361017488 TargetScan -0.149654623473878 4.805902500454e-17 NA NA NA hsa-miR-141-3p EPB41L3 5.02396127982626 2.19224509139725e-24 -1.63344198757467 7.20507965391242e-05 miRNATAP -0.292529346530813 3.31274956469315e-15 NA NA NA hsa-miR-141-3p EPHA7 5.02396127982626 2.19224509139725e-24 -4.20206952913252 6.81894380739864e-12 TargetScan;miRNATAP -0.330815924436256 7.49589080274753e-09 26261572 Among those the expression of EPHA7 and PI15 were negatively correlated with that of microRNA-141 and they were also identified as potential targets of this microRNA via microRNA-mRNA interaction; We thus concluded that microRNA-141 EPHA7 and PI15 might jointly participate in the regulation of drug resistance in ovarian cancer and serve as potential targets in targeted therapies drug resistance ovarian cancer hsa-miR-141-3p ERC2 5.02396127982626 2.19224509139725e-24 -0.0824641536555695 0.866171635880599 MirTarget;TargetScan -0.105782107218275 0.0193358207021086 NA NA NA hsa-miR-141-3p ERG 5.02396127982626 2.19224509139725e-24 -1.3479378771967 2.23511589174121e-07 MirTarget;TargetScan -0.253013233433548 1.37986124332074e-28 NA NA NA hsa-miR-141-3p ETS1 5.02396127982626 2.19224509139725e-24 -0.699528618233348 0.00228038287696191 mirMAP -0.136403222013607 5.63450066135883e-11 NA NA NA hsa-miR-141-3p FAM133A 5.02396127982626 2.19224509139725e-24 -0.536633813285275 0.494531763298327 mirMAP -0.314537291307707 1.27130797078722e-05 NA NA NA hsa-miR-141-3p FAM167A 5.02396127982626 2.19224509139725e-24 0.270294509636431 0.487790761066615 mirMAP -0.19322302650933 5.23365663962573e-08 NA NA NA hsa-miR-141-3p FAM168A 5.02396127982626 2.19224509139725e-24 -0.715878355157019 0.0048087062534339 TargetScan -0.170237723829022 9.85489573786363e-14 NA NA NA hsa-miR-141-3p FAM168B 5.02396127982626 2.19224509139725e-24 -0.9465480741702 2.76446564795563e-10 MirTarget;TargetScan -0.108770444818815 1.75199417266574e-15 NA NA NA hsa-miR-141-3p FAM20C 5.02396127982626 2.19224509139725e-24 -1.33283956490135 0.0018135829325117 MirTarget -0.462532522787813 3.40051627730541e-37 NA NA NA hsa-miR-141-3p FAM26E 5.02396127982626 2.19224509139725e-24 -1.51380317009881 3.60338715627852e-05 mirMAP -0.406365683654429 5.41026450908213e-39 NA NA NA hsa-miR-141-3p FAM46C 5.02396127982626 2.19224509139725e-24 -1.66367766872796 7.82547314993614e-08 TargetScan;miRNATAP -0.106435921017189 0.0002379062668133 NA NA NA hsa-miR-141-3p FAT3 5.02396127982626 2.19224509139725e-24 -2.79096679677476 3.40343867448209e-06 MirTarget;miRNATAP -0.243303201500778 1.29983926491812e-05 NA NA NA hsa-miR-141-3p FER 5.02396127982626 2.19224509139725e-24 -0.960481943610693 0.000174638463493531 mirMAP -0.182765281232224 2.13399687007402e-15 NA NA NA hsa-miR-141-3p FGF13 5.02396127982626 2.19224509139725e-24 -2.79657067303141 1.56359356599715e-14 TargetScan -0.302898746415501 8.87758287571865e-20 NA NA NA hsa-miR-141-3p FKBP5 5.02396127982626 2.19224509139725e-24 -1.54368679613987 4.05564573895986e-05 TargetScan -0.388803729060971 3.70334274744257e-33 NA NA NA hsa-miR-141-3p FLI1 5.02396127982626 2.19224509139725e-24 -1.10881984531465 6.56713737767845e-05 TargetScan -0.284561790021729 1.4696047688211e-32 NA NA NA hsa-miR-141-3p FNIP2 5.02396127982626 2.19224509139725e-24 -0.757876478794657 0.0104512107248218 TargetScan -0.15293019658296 1.51005751533022e-08 NA NA NA hsa-miR-141-3p FOXN3 5.02396127982626 2.19224509139725e-24 -1.43525991184281 2.70084540955391e-16 MirTarget;TargetScan;miRNATAP -0.144244534851771 3.13744918937603e-19 NA NA NA hsa-miR-141-3p FOXP2 5.02396127982626 2.19224509139725e-24 -3.99353205302265 7.58170962329672e-11 TargetScan -0.492242020268146 1.02220254321097e-18 NA NA NA hsa-miR-141-3p FRMD6 5.02396127982626 2.19224509139725e-24 -0.932146068496432 0.00182819765018773 MirTarget;TargetScan;miRNATAP -0.116995591435815 2.21065057353424e-05 NA NA NA hsa-miR-141-3p FSD1L 5.02396127982626 2.19224509139725e-24 -0.147593029414252 0.718548814950206 TargetScan -0.293153485317503 1.08240803873113e-15 NA NA NA hsa-miR-141-3p FTO 5.02396127982626 2.19224509139725e-24 -0.521763496896368 9.56066637934397e-05 mirMAP -0.103295701715657 4.48104012531606e-18 NA NA NA hsa-miR-141-3p FYCO1 5.02396127982626 2.19224509139725e-24 -1.6226100593392 1.01871130782658e-16 mirMAP -0.119610814609639 7.37134797454179e-11 NA NA NA hsa-miR-141-3p FZD4 5.02396127982626 2.19224509139725e-24 -0.82842258037894 0.00067769989049317 TargetScan -0.113168852885507 4.32145832906429e-07 NA NA NA hsa-miR-141-3p GAB2 5.02396127982626 2.19224509139725e-24 -1.20165054399091 1.06247685933273e-06 mirMAP -0.132797466896447 4.66744464034186e-09 NA NA NA hsa-miR-141-3p GATA6 5.02396127982626 2.19224509139725e-24 -3.38076408789276 2.92272151179456e-14 TargetScan;miRNATAP -0.506838016893668 2.69884556190457e-39 NA NA NA hsa-miR-141-3p GCNT2 5.02396127982626 2.19224509139725e-24 -0.712162617542869 0.0826580493563988 TargetScan -0.111158126943812 0.00337209235210958 NA NA NA hsa-miR-141-3p GDF6 5.02396127982626 2.19224509139725e-24 -1.13505992050111 0.0279057480958108 TargetScan -0.341173884857515 2.2217799210351e-13 NA NA NA hsa-miR-141-3p GEM 5.02396127982626 2.19224509139725e-24 -3.69134770515528 5.61525969896728e-16 MirTarget -0.587565485490449 1.27714231653948e-52 NA NA NA hsa-miR-141-3p GFRA1 5.02396127982626 2.19224509139725e-24 -4.99535302188274 6.14065741522982e-16 mirMAP -0.393365060968066 1.10917039753486e-11 NA NA NA hsa-miR-141-3p GFRA2 5.02396127982626 2.19224509139725e-24 -3.21725146250063 1.33382900263128e-15 mirMAP -0.444794470460335 2.93223082155244e-36 NA NA NA hsa-miR-141-3p GJC1 5.02396127982626 2.19224509139725e-24 -0.972020676723743 0.00222017431601357 MirTarget;TargetScan;miRNATAP -0.25162506617731 5.57057070933156e-19 NA NA NA hsa-miR-141-3p GLI2 5.02396127982626 2.19224509139725e-24 -2.28902662613598 1.9678941791174e-06 MirTarget -0.490600186796826 7.08521741863515e-32 NA NA NA hsa-miR-141-3p GLRX 5.02396127982626 2.19224509139725e-24 -0.275147826859437 0.316770480646163 MirTarget;TargetScan;miRNATAP -0.133787914261733 9.284256458484e-08 NA NA NA hsa-miR-141-3p GNA12 5.02396127982626 2.19224509139725e-24 -0.327866213861197 0.0839906551813244 mirMAP -0.159733729112464 9.55959524392438e-22 NA NA NA hsa-miR-141-3p GNE 5.02396127982626 2.19224509139725e-24 -0.892555191707626 0.00298922209935849 MirTarget -0.129102780931227 3.01283936788047e-06 NA NA NA hsa-miR-141-3p GNG4 5.02396127982626 2.19224509139725e-24 0.216159437363437 0.744682539041036 mirMAP -0.31409320803834 2.17335380219881e-07 NA NA NA hsa-miR-141-3p GNG7 5.02396127982626 2.19224509139725e-24 -3.47904747202308 1.83990532659951e-21 MirTarget;TargetScan;miRNATAP -0.30384219654589 5.18426669901378e-19 NA NA NA hsa-miR-141-3p GPC6 5.02396127982626 2.19224509139725e-24 -2.70666453497929 7.48358520640858e-07 TargetScan -0.642273653881201 3.28967946680011e-44 NA NA NA hsa-miR-141-3p GPD1 5.02396127982626 2.19224509139725e-24 -1.45048771597392 0.00525960664850103 TargetScan -0.193297434147106 5.55590553635821e-05 NA NA NA hsa-miR-141-3p GPM6B 5.02396127982626 2.19224509139725e-24 -2.38616048413304 8.19968989398376e-13 TargetScan;miRNATAP -0.297794469902579 4.04873608589634e-23 NA NA NA hsa-miR-141-3p GPR174 5.02396127982626 2.19224509139725e-24 -0.709153603867135 0.15454442855266 TargetScan -0.28228130170386 4.20449049957377e-10 NA NA NA hsa-miR-141-3p GPR63 5.02396127982626 2.19224509139725e-24 -0.916305216112567 0.0143681611862448 TargetScan -0.152935149429126 8.84758404382338e-06 NA NA NA hsa-miR-141-3p GPRC5B 5.02396127982626 2.19224509139725e-24 -0.92103982223247 0.0084283568696958 mirMAP -0.171082278386794 8.92862761745291e-08 NA NA NA hsa-miR-141-3p GRAP2 5.02396127982626 2.19224509139725e-24 -1.99328764327358 4.55220376112541e-06 mirMAP -0.340788701134229 2.53690358789535e-18 NA NA NA hsa-miR-141-3p GRIK3 5.02396127982626 2.19224509139725e-24 -4.42199547952411 9.71715591269923e-16 mirMAP -0.341467034564714 3.89334996772762e-11 NA NA NA hsa-miR-141-3p GRIN3A 5.02396127982626 2.19224509139725e-24 -0.237867214305963 0.403188120647802 TargetScan;miRNATAP -0.189882395288036 1.03259609480364e-13 NA NA NA hsa-miR-141-3p GSN 5.02396127982626 2.19224509139725e-24 -2.39108746525379 5.58907404692594e-22 MirTarget -0.263776531040741 4.84764945367784e-32 NA NA NA hsa-miR-141-3p HAS2 5.02396127982626 2.19224509139725e-24 -1.4533402537015 0.0063112329586836 MirTarget -0.365296908517968 2.41269196709147e-14 NA NA NA hsa-miR-141-3p HDAC4 5.02396127982626 2.19224509139725e-24 -1.80036091395253 1.96398022917234e-18 TargetScan;miRNATAP -0.224498344325949 7.77378690757405e-35 NA NA NA hsa-miR-141-3p HECW1 5.02396127982626 2.19224509139725e-24 0.0775842383611329 0.876990656803428 TargetScan -0.232466652099627 3.80438164884885e-07 NA NA NA hsa-miR-141-3p HEYL 5.02396127982626 2.19224509139725e-24 -0.309360248202531 0.275918394616269 mirMAP -0.213270840967025 3.00765131550456e-17 NA NA NA hsa-miR-141-3p HGF 5.02396127982626 2.19224509139725e-24 -2.96833708580794 2.21214820634191e-07 MirTarget;TargetScan -0.676636907580645 1.12497659260577e-44 NA NA NA hsa-miR-141-3p HIPK3 5.02396127982626 2.19224509139725e-24 -1.74508965708072 2.92750932105647e-06 MirTarget;TargetScan -0.221123587925148 9.98617371242522e-11 NA NA NA hsa-miR-141-3p HIVEP3 5.02396127982626 2.19224509139725e-24 0.0288071997334853 0.920325184162576 mirMAP -0.174760553143419 1.75045749365667e-11 NA NA NA hsa-miR-141-3p HLF 5.02396127982626 2.19224509139725e-24 -5.48181644757567 4.24267397704754e-28 TargetScan -0.59042899505983 1.76085178870284e-39 NA NA NA hsa-miR-141-3p HOXA11 5.02396127982626 2.19224509139725e-24 -0.779286751498244 0.0292176238744169 TargetScan;miRNATAP -0.123667292408771 0.000174087134451521 NA NA NA hsa-miR-141-3p HS3ST3B1 5.02396127982626 2.19224509139725e-24 -0.639453810462205 0.183372048335563 mirMAP -0.382910834502429 2.28072861709081e-19 NA NA NA hsa-miR-141-3p HSPA13 5.02396127982626 2.19224509139725e-24 -0.287922247159853 0.106347732939114 TargetScan -0.133647269763646 3.30479934756916e-17 NA NA NA hsa-miR-141-3p IFFO2 5.02396127982626 2.19224509139725e-24 -0.910440393472385 0.00201393161780154 MirTarget;TargetScan -0.101515155443113 0.000194771695236261 NA NA NA hsa-miR-141-3p IGDCC4 5.02396127982626 2.19224509139725e-24 -1.98591119557307 4.45190548749867e-08 TargetScan;miRNATAP -0.350675967176301 4.59141518716107e-28 NA NA NA hsa-miR-141-3p IGF2BP2 5.02396127982626 2.19224509139725e-24 0.953732727730338 0.144541577214548 MirTarget;TargetScan;miRNATAP -0.30821004751603 2.48916654507274e-07 NA NA NA hsa-miR-141-3p IGSF6 5.02396127982626 2.19224509139725e-24 0.285339839382025 0.483514527935796 TargetScan -0.261703720411169 9.3016910892664e-13 NA NA NA hsa-miR-141-3p IGSF9B 5.02396127982626 2.19224509139725e-24 -3.70052179046043 2.07484176922388e-13 TargetScan -0.381073867495267 2.00085566827593e-16 NA NA NA hsa-miR-141-3p IL18R1 5.02396127982626 2.19224509139725e-24 -0.493217737310222 0.124639520069653 MirTarget -0.133638408696018 5.67399116458649e-06 NA NA NA hsa-miR-141-3p IL6R 5.02396127982626 2.19224509139725e-24 -1.86576803083567 2.67166891084766e-06 MirTarget -0.23775486835915 6.49333048566365e-11 NA NA NA hsa-miR-141-3p IRAK3 5.02396127982626 2.19224509139725e-24 -1.61324599744624 9.44362061411831e-07 mirMAP -0.237412262860539 1.63026403262395e-15 NA NA NA hsa-miR-141-3p IRS2 5.02396127982626 2.19224509139725e-24 -0.911324412136108 0.0110242467169193 MirTarget;TargetScan;miRNATAP -0.156621642072101 1.95203993217853e-06 27186273 Forced expression of IRS2 reversed the inhibition effect induced by miR-141 overexpression in thyroid cancer cells; Taken together our study provides the first evidence that miR-141 suppressed thyroid cancer cell growth and metastasis through inhibition of IRS2 metastasis thyroid cancer hsa-miR-141-3p ITGAV 5.02396127982626 2.19224509139725e-24 -0.0552493406333632 0.795714969238101 MirTarget -0.125634945314397 7.01655633438231e-11 NA NA NA hsa-miR-141-3p ITSN1 5.02396127982626 2.19224509139725e-24 -0.611059124760145 8.82737803628848e-05 TargetScan;mirMAP -0.102708277571066 3.091769116372e-13 NA NA NA hsa-miR-141-3p JAZF1 5.02396127982626 2.19224509139725e-24 -1.91995536790338 5.72076669427973e-12 MirTarget;miRNATAP -0.376797677136439 1.81571796311472e-61 NA NA NA hsa-miR-141-3p JUN 5.02396127982626 2.19224509139725e-24 -2.04611084807692 9.1524625995215e-13 miRNATAP -0.202238939720509 1.9524950223322e-14 NA NA NA hsa-miR-141-3p KATNAL1 5.02396127982626 2.19224509139725e-24 -1.57600243048234 8.15704001509067e-06 TargetScan -0.399081005798051 1.42565068629602e-40 NA NA NA hsa-miR-141-3p KBTBD11 5.02396127982626 2.19224509139725e-24 -2.19338266624558 6.41970854972395e-08 mirMAP -0.207712957508786 3.24509579623034e-08 NA NA NA hsa-miR-141-3p KCNIP4 5.02396127982626 2.19224509139725e-24 -1.64344411900392 3.99391332083586e-14 MirTarget -0.115762588911047 1.42923692275574e-08 NA NA NA hsa-miR-141-3p KCNJ2 5.02396127982626 2.19224509139725e-24 -0.281197518883409 0.36164514317052 TargetScan;miRNATAP -0.13499003532713 1.68671807814994e-06 NA NA NA hsa-miR-141-3p KCNK3 5.02396127982626 2.19224509139725e-24 -3.6338132446768 1.0612212729052e-10 mirMAP -0.536679604994079 7.34243209122856e-27 NA NA NA hsa-miR-141-3p KCTD12 5.02396127982626 2.19224509139725e-24 -1.63231238822131 6.91166356828654e-08 TargetScan -0.35610805061715 3.26382891941958e-44 NA NA NA hsa-miR-141-3p KCTD20 5.02396127982626 2.19224509139725e-24 -0.81380310423214 2.36532656017097e-06 MirTarget;TargetScan -0.115246052153293 1.79621314879822e-13 NA NA NA hsa-miR-141-3p KCTD7 5.02396127982626 2.19224509139725e-24 -0.720453948905683 7.81616343021298e-05 mirMAP -0.123682791343706 6.04208833240884e-14 NA NA NA hsa-miR-141-3p KHDC1 5.02396127982626 2.19224509139725e-24 -0.636944502978112 0.156898551752884 miRNATAP -0.266703226249492 5.80516402692101e-11 NA NA NA hsa-miR-141-3p KHDRBS3 5.02396127982626 2.19224509139725e-24 -1.40834477366019 0.00168295652691807 TargetScan -0.237387720367083 7.00246755571617e-09 NA NA NA hsa-miR-141-3p KIAA0408 5.02396127982626 2.19224509139725e-24 -6.3487100842187 6.23110294275788e-17 MirTarget;TargetScan -0.604271666983291 7.79609944603074e-18 NA NA NA hsa-miR-141-3p KIAA1644 5.02396127982626 2.19224509139725e-24 -4.40439862301283 1.42085780669109e-16 mirMAP -0.716686333897475 1.50217356415633e-58 NA NA NA hsa-miR-141-3p KIAA2022 5.02396127982626 2.19224509139725e-24 -3.77781848258777 1.47825574429182e-12 MirTarget;TargetScan -0.439294725422072 1.58112385618876e-19 NA NA NA hsa-miR-141-3p KIF17 5.02396127982626 2.19224509139725e-24 -1.22170857097799 7.98355624690093e-05 MirTarget;TargetScan -0.29774784532447 2.72875897598259e-28 NA NA NA hsa-miR-141-3p KIF1B 5.02396127982626 2.19224509139725e-24 -0.678468502639348 1.60841697720107e-05 mirMAP -0.100473248145699 1.95834362605822e-12 NA NA NA hsa-miR-141-3p KLF11 5.02396127982626 2.19224509139725e-24 -0.893024981436906 6.97406562236998e-06 miRNAWalker2_validate;MirTarget -0.109127392186737 2.1048242253222e-09 NA NA NA hsa-miR-141-3p KLF12 5.02396127982626 2.19224509139725e-24 -1.46917100719464 1.42059321169598e-05 MirTarget;TargetScan -0.306963108494665 7.72867329137965e-25 NA NA NA hsa-miR-141-3p KLF6 5.02396127982626 2.19224509139725e-24 -1.55016190855485 5.47257871397641e-12 TargetScan;miRNATAP -0.109493712289628 2.03959262644186e-07 NA NA NA hsa-miR-141-3p KPNA3 5.02396127982626 2.19224509139725e-24 -0.573359539342796 0.00262291748998806 MirTarget;TargetScan;miRNATAP -0.100889364758159 6.41762677485833e-09 NA NA NA hsa-miR-141-3p LCP2 5.02396127982626 2.19224509139725e-24 -0.697473139527702 0.0518041282954198 MirTarget -0.292356176350176 2.94269967183768e-20 NA NA NA hsa-miR-141-3p LHFP 5.02396127982626 2.19224509139725e-24 -1.83125704677191 4.20141501543429e-10 MirTarget -0.332640509877499 5.90653624144378e-40 NA NA NA hsa-miR-141-3p LHX6 5.02396127982626 2.19224509139725e-24 -0.886870795693206 0.00203651922651584 MirTarget;TargetScan;miRNATAP -0.1925609723839 1.13024579333871e-13 NA NA NA hsa-miR-141-3p LIF 5.02396127982626 2.19224509139725e-24 -1.6300990984737 3.46879078767171e-05 mirMAP -0.211882464421913 4.50278438467506e-09 NA NA NA hsa-miR-141-3p LMO3 5.02396127982626 2.19224509139725e-24 -4.72180755919393 2.71125773614461e-13 MirTarget;TargetScan -0.479006861419375 8.39238892548966e-16 NA NA NA hsa-miR-141-3p LONRF2 5.02396127982626 2.19224509139725e-24 -3.8642101573018 7.90463940348435e-08 TargetScan -0.288517477326301 1.73240320824398e-05 NA NA NA hsa-miR-141-3p LPIN2 5.02396127982626 2.19224509139725e-24 -0.645218563894799 0.0164829454490252 TargetScan -0.128406002392285 1.81732698831014e-07 NA NA NA hsa-miR-141-3p LPP 5.02396127982626 2.19224509139725e-24 -2.04092311415528 2.98839088727532e-15 TargetScan;miRNATAP -0.229401213243655 1.67846288845394e-22 NA NA NA hsa-miR-141-3p LSAMP 5.02396127982626 2.19224509139725e-24 -2.02817683260413 4.22567550720738e-06 TargetScan -0.277344367575573 5.56843771499789e-12 NA NA NA hsa-miR-141-3p LTBP1 5.02396127982626 2.19224509139725e-24 -1.09891861471167 0.000129213237016863 MirTarget -0.211434558427624 2.47291192802919e-16 NA NA NA hsa-miR-141-3p MACF1 5.02396127982626 2.19224509139725e-24 -0.874277509919207 1.10820730213329e-06 TargetScan -0.173333337794005 2.19082057923565e-28 NA NA NA hsa-miR-141-3p MAF 5.02396127982626 2.19224509139725e-24 -1.28341922239874 0.00015825213662883 miRNATAP -0.30818214426818 5.41571256021845e-25 NA NA NA hsa-miR-141-3p MAGI2 5.02396127982626 2.19224509139725e-24 -1.89478051791337 8.17403291700624e-13 TargetScan;miRNATAP -0.156969824639809 1.99328593268779e-10 NA NA NA hsa-miR-141-3p MAP1B 5.02396127982626 2.19224509139725e-24 -3.18358434812783 4.83606017602339e-16 mirMAP -0.542040813296232 2.39221657606778e-63 NA NA NA hsa-miR-141-3p MAP2 5.02396127982626 2.19224509139725e-24 -0.753572928246066 0.0970780637395552 miRNATAP -0.224308127471618 6.27701437913552e-08 NA NA NA hsa-miR-141-3p MAP3K3 5.02396127982626 2.19224509139725e-24 -0.867302315651695 4.69975718275905e-09 miRNATAP -0.172869710454037 2.24127810311963e-43 NA NA NA hsa-miR-141-3p MAP4K4 5.02396127982626 2.19224509139725e-24 0.130872521838526 0.522814141079271 TargetScan -0.132557176493888 5.6923535135779e-13 24013097 To understand how miR-141 mediates the phenotype of pancreatic cancer cells a bioinformatics tool was used to identify MAP4K4 as a potential target of miR-141; The Dual-Luciferase reporter gene assay showed that miR-141 binds directly to the 3'-untranslated region 3'UTR of MAP4K4 to inhibit MAP4K4 expression; Western blot and quantitative real-time PCR qRT-PCR analyses revealed that MAP4K4 expression was inversely correlated with miR-141 expression both in pancreatic cancer samples and cell lines; In a nude mouse xenograft model both overexpression of miR-141 and knockdown of MAP4K4 significantly repressed pancreatic cancer cell growth; Therefore we conclude that miR-141 targets MAP4K4 acts as a tumor suppressor in pancreatic cancer cells and may serve as a novel therapeutic agent for miRNA-based pancreatic cancer therapy pancreatic cancer hsa-miR-141-3p MAP7D1 5.02396127982626 2.19224509139725e-24 -0.519333178125198 0.0019025932511054 MirTarget;TargetScan;miRNATAP -0.139324129382877 3.90527399743627e-21 NA NA NA hsa-miR-141-3p MAPRE2 5.02396127982626 2.19224509139725e-24 -1.48556495228465 7.11230591567608e-09 TargetScan -0.297976282854019 1.42852580439143e-42 NA NA NA hsa-miR-141-3p MARCH1 5.02396127982626 2.19224509139725e-24 0.249895584717324 0.347593448523703 TargetScan;miRNATAP -0.156359618437464 8.01678188057464e-11 NA NA NA hsa-miR-141-3p MBNL1 5.02396127982626 2.19224509139725e-24 -1.03715217368983 1.91023114600054e-14 MirTarget;TargetScan;miRNATAP -0.145917544232527 9.07487014206932e-35 NA NA NA hsa-miR-141-3p MBNL3 5.02396127982626 2.19224509139725e-24 -1.39664025928726 7.58496847232093e-05 MirTarget;TargetScan;miRNATAP -0.118158255437449 0.000310538356420404 NA NA NA hsa-miR-141-3p MDGA1 5.02396127982626 2.19224509139725e-24 -1.00154386684221 0.0303398006837731 TargetScan;miRNATAP -0.351329630228369 1.52044327594317e-17 NA NA NA hsa-miR-210-3p MDGA1 6.07079758655679 2.22120227133377e-28 -1.00154386684221 0.0303398006837731 miRNAWalker2_validate -0.177758156373944 2.379457505793e-06 NA NA NA hsa-miR-141-3p MEIS2 5.02396127982626 2.19224509139725e-24 -1.72135417174124 5.81040155633491e-11 TargetScan -0.160153615098597 4.73599763955798e-11 NA NA NA hsa-miR-141-3p MGAT5 5.02396127982626 2.19224509139725e-24 -0.948205856410471 0.00642407288737583 TargetScan;mirMAP -0.119333456003193 0.000203629579724751 NA NA NA hsa-miR-141-3p MMP16 5.02396127982626 2.19224509139725e-24 -1.93731176203338 4.78308892783825e-06 TargetScan -0.393402814041786 4.69903101645432e-26 NA NA NA hsa-miR-141-3p MN1 5.02396127982626 2.19224509139725e-24 -2.44287385467581 8.2364144685939e-08 TargetScan -0.469862250730746 1.87729549679021e-32 NA NA NA hsa-miR-210-3p MPEG1 6.07079758655679 2.22120227133377e-28 -1.65814079681193 3.85903819290953e-05 MirTarget -0.320085307825935 3.4230493374086e-24 NA NA NA hsa-miR-141-3p MYBL1 5.02396127982626 2.19224509139725e-24 -0.198825078797647 0.492088677772154 TargetScan;miRNATAP -0.176286176102791 1.47359490638079e-11 NA NA NA hsa-miR-141-3p MYH10 5.02396127982626 2.19224509139725e-24 -0.113066852038276 0.614876476546525 TargetScan;miRNATAP -0.153321303486404 2.48531788097192e-14 NA NA NA hsa-miR-141-3p MYO5A 5.02396127982626 2.19224509139725e-24 -0.274576441491861 0.311620335084615 TargetScan -0.206712590727665 9.59919356304138e-18 NA NA NA hsa-miR-141-3p MYO9A 5.02396127982626 2.19224509139725e-24 -1.29622192336459 1.1786138431555e-06 TargetScan -0.14343034253547 5.21704135269981e-09 NA NA NA hsa-miR-141-3p MYRIP 5.02396127982626 2.19224509139725e-24 -3.80555290345801 1.14017259779893e-12 MirTarget;TargetScan -0.199903098152316 7.8826439177152e-05 NA NA NA hsa-miR-141-3p NAMPT 5.02396127982626 2.19224509139725e-24 -1.01188888675403 7.98621574991513e-05 miRNATAP -0.137907485727215 4.38663947784095e-09 NA NA NA hsa-miR-141-3p NAV3 5.02396127982626 2.19224509139725e-24 -3.21771083204903 7.35356644104861e-11 mirMAP -0.606782843027449 3.71206011455211e-48 NA NA NA hsa-miR-141-3p NCAM1 5.02396127982626 2.19224509139725e-24 -5.46812766536887 2.35522582039703e-18 TargetScan -0.805643363470641 1.26938223389983e-51 NA NA NA hsa-miR-210-3p NCAM1 6.07079758655679 2.22120227133377e-28 -5.46812766536887 2.35522582039703e-18 miRNAWalker2_validate;miRTarBase -0.689476481684231 4.68819389749096e-47 NA NA NA hsa-miR-141-3p NECAB1 5.02396127982626 2.19224509139725e-24 -3.26252425353249 2.74412248921453e-12 MirTarget;TargetScan -0.490602041605141 5.38471060642007e-33 NA NA NA hsa-miR-141-3p NEK6 5.02396127982626 2.19224509139725e-24 -0.544239957677025 0.104572175212416 MirTarget;TargetScan -0.308507320351745 3.84776984127134e-26 NA NA NA hsa-miR-141-3p NEURL1B 5.02396127982626 2.19224509139725e-24 -1.41325934404162 2.67307373486688e-07 mirMAP -0.231737019794621 3.59108379699189e-21 NA NA NA hsa-miR-141-3p NFASC 5.02396127982626 2.19224509139725e-24 -2.95717922837883 4.31475260476481e-14 MirTarget;TargetScan;miRNATAP -0.304221401150199 2.88851937906312e-17 NA NA NA hsa-miR-141-3p NFIA 5.02396127982626 2.19224509139725e-24 -2.09936885926166 1.0458025267903e-15 TargetScan;miRNATAP -0.21056311469311 2.19268296919497e-18 NA NA NA hsa-miR-141-3p NMNAT2 5.02396127982626 2.19224509139725e-24 -0.388609911601026 0.428797428186375 miRNATAP -0.225154516940894 5.2650384281902e-07 NA NA NA hsa-miR-141-3p NOVA1 5.02396127982626 2.19224509139725e-24 -4.21914714578111 7.21315612695789e-16 miRNATAP -0.429459072642794 4.17969981650815e-19 NA NA NA hsa-miR-141-3p NPAS3 5.02396127982626 2.19224509139725e-24 -2.24907906516082 1.91416491531777e-06 TargetScan;miRNATAP -0.31082359651629 5.11859388646725e-13 NA NA NA hsa-miR-141-3p NPC1 5.02396127982626 2.19224509139725e-24 -0.0845907427747106 0.656311240831085 MirTarget;TargetScan -0.10141342572552 3.99908798547029e-09 NA NA NA hsa-miR-141-3p NPTX1 5.02396127982626 2.19224509139725e-24 -3.0548528465665 5.58655593069716e-09 TargetScan;miRNATAP -0.317221091523751 5.28128507298689e-11 NA NA NA hsa-miR-210-3p NPTX1 6.07079758655679 2.22120227133377e-28 -3.0548528465665 5.58655593069716e-09 miRNAWalker2_validate;miRTarBase -0.334749226448501 3.07349072508097e-15 NA NA NA hsa-miR-141-3p NR3C1 5.02396127982626 2.19224509139725e-24 -1.29490546417786 3.89055618845506e-05 TargetScan -0.295170348516288 9.42370767036473e-27 NA NA NA hsa-miR-141-3p NRCAM 5.02396127982626 2.19224509139725e-24 1.51659381182303 0.003170728944007 TargetScan -0.105508016559009 0.0271834551730992 NA NA NA hsa-miR-141-3p NRP1 5.02396127982626 2.19224509139725e-24 -0.612408058927576 0.0291452451283254 TargetScan;miRNATAP -0.255348299355813 1.85031947127184e-25 NA NA NA hsa-miR-141-3p NRP2 5.02396127982626 2.19224509139725e-24 -1.68096989171122 2.48125634647159e-05 TargetScan;miRNATAP -0.502017233487188 2.96922549758946e-53 NA NA NA hsa-miR-141-3p NRSN2 5.02396127982626 2.19224509139725e-24 -0.330465623325308 0.250945572044971 MirTarget -0.110325550270995 2.96428406227536e-05 NA NA NA hsa-miR-141-3p NRXN1 5.02396127982626 2.19224509139725e-24 -6.57168194390169 3.69107862170798e-26 MirTarget;TargetScan;miRNATAP -0.667046956110465 6.52379560861006e-32 NA NA NA hsa-miR-141-3p NTRK3 5.02396127982626 2.19224509139725e-24 -5.17034960965042 5.23662623079398e-21 mirMAP -0.496811560602054 1.26226870960282e-22 NA NA NA hsa-miR-141-3p NUMBL 5.02396127982626 2.19224509139725e-24 -0.572631697203964 0.00314600902770347 TargetScan -0.150911963397294 2.13456017848362e-18 NA NA NA hsa-miR-141-3p OGFRL1 5.02396127982626 2.19224509139725e-24 -0.562576926083616 0.128325913264999 TargetScan -0.265931932396274 8.72716128230255e-16 NA NA NA hsa-miR-141-3p OLFM1 5.02396127982626 2.19224509139725e-24 -3.69448823851136 3.94169138374679e-16 MirTarget;TargetScan;miRNATAP -0.457030729324371 2.53149879132377e-29 NA NA NA hsa-miR-141-3p OLFML2A 5.02396127982626 2.19224509139725e-24 -1.0263532421833 0.000962903460469688 mirMAP -0.216135583464069 1.17744624452523e-14 NA NA NA hsa-miR-141-3p OSBPL10 5.02396127982626 2.19224509139725e-24 -1.83322990423673 6.62607328092423e-12 mirMAP -0.239912030168834 1.53794516155206e-23 NA NA NA hsa-miR-141-3p OSBPL1A 5.02396127982626 2.19224509139725e-24 -1.28931675013637 1.82641604881751e-06 TargetScan -0.180936045111728 1.80508686660405e-13 NA NA NA hsa-miR-141-3p OSBPL6 5.02396127982626 2.19224509139725e-24 -1.61152035107552 0.00474080031102192 MirTarget;TargetScan;miRNATAP -0.542659142890387 7.41773493874935e-28 NA NA NA hsa-miR-141-3p P2RY1 5.02396127982626 2.19224509139725e-24 -1.88677816260565 6.94120829937246e-05 TargetScan -0.131524674767249 0.00289329932777245 NA NA NA hsa-miR-141-3p PALM2-AKAP2 5.02396127982626 2.19224509139725e-24 -1.62425751829219 3.00539592164251e-07 TargetScan;miRNATAP -0.378702933299226 4.70023082891259e-46 NA NA NA hsa-miR-141-3p PAPLN 5.02396127982626 2.19224509139725e-24 -0.241943294054047 0.455530000462733 TargetScan -0.192564254132522 4.98870627642303e-11 NA NA NA hsa-miR-141-3p PAPPA 5.02396127982626 2.19224509139725e-24 -1.75955305841573 0.000134461135734203 MirTarget;TargetScan;miRNATAP -0.347370588052235 4.46409718289252e-17 NA NA NA hsa-miR-141-3p PAQR5 5.02396127982626 2.19224509139725e-24 -0.0247252301101912 0.956044849342471 MirTarget;TargetScan -0.129292481797794 0.00176773845410547 NA NA NA hsa-miR-141-3p PAX3 5.02396127982626 2.19224509139725e-24 -0.660994210613064 0.281011412138486 TargetScan -0.119014117319377 0.0359774490427443 NA NA NA hsa-miR-141-3p PCDH17 5.02396127982626 2.19224509139725e-24 -0.31543828817169 0.277167062556602 miRNATAP -0.147564899122846 2.34395281845491e-08 NA NA NA hsa-miR-141-3p PCDH9 5.02396127982626 2.19224509139725e-24 -3.58942089789521 1.17285101943991e-09 MirTarget;miRNATAP -0.590356224897316 5.28325615006607e-30 NA NA NA hsa-miR-210-3p PCYT1B 6.07079758655679 2.22120227133377e-28 -1.53756359837056 0.00358733905606093 MirTarget -0.216658094189243 4.78043241593753e-07 NA NA NA hsa-miR-141-3p PDE1C 5.02396127982626 2.19224509139725e-24 -4.13701966391324 7.08661414779568e-16 mirMAP -0.511083039603708 1.03070480064241e-28 NA NA NA hsa-miR-141-3p PDGFRA 5.02396127982626 2.19224509139725e-24 -2.37640583073564 1.39737819859365e-09 MirTarget -0.379513640202387 7.11112956696243e-28 NA NA NA hsa-miR-141-3p PDZD2 5.02396127982626 2.19224509139725e-24 -0.660901601186232 0.0797147776322342 TargetScan -0.181839965659049 1.30740485459763e-07 NA NA NA hsa-miR-210-3p PDZD4 6.07079758655679 2.22120227133377e-28 -3.50328419678476 5.69234493908284e-16 MirTarget -0.334937591822741 1.37127211346789e-21 NA NA NA hsa-miR-141-3p PEG3 5.02396127982626 2.19224509139725e-24 -3.78948650332683 1.02338376531654e-12 TargetScan -0.346980443744125 2.01508846200066e-12 NA NA NA hsa-miR-141-3p PGM2L1 5.02396127982626 2.19224509139725e-24 -1.01115316371046 0.000101645754958713 TargetScan -0.228633666115396 2.2474024963306e-23 NA NA NA hsa-miR-141-3p PHLPP2 5.02396127982626 2.19224509139725e-24 -0.542526414508152 0.00198752699211246 MirTarget;TargetScan;miRNATAP -0.104884442280012 4.29809622480929e-11 24945731 MicroRNA 141 promotes the proliferation of non small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2; Together the results of this study suggest that miR-141 and its targets PHLPP1 and PHLPP2 play critical roles in NSCLC tumorigenesis and provide potential therapeutic targets for NSCLC treatment tumorigenesis lung squamous cell cancer hsa-miR-141-3p PHYHIPL 5.02396127982626 2.19224509139725e-24 -1.3403818845059 0.020958999472695 MirTarget;TargetScan;miRNATAP -0.245737656387445 4.07445009992431e-06 NA NA NA hsa-miR-141-3p PITX2 5.02396127982626 2.19224509139725e-24 -2.22753708360439 1.34545225235821e-06 TargetScan;miRNATAP -0.274614578689398 8.14562643219687e-11 NA NA NA hsa-miR-141-3p PLCB4 5.02396127982626 2.19224509139725e-24 -3.76947582666435 4.09541818232216e-14 TargetScan -0.288518356683351 6.78415934849381e-10 NA NA NA hsa-miR-141-3p PLCL1 5.02396127982626 2.19224509139725e-24 -2.35657424868599 1.25135556692163e-13 MirTarget;TargetScan -0.385622908652975 6.97070144503964e-46 NA NA NA hsa-miR-141-3p PLCXD3 5.02396127982626 2.19224509139725e-24 -2.49859819439077 0.000929772953384917 TargetScan;miRNATAP -0.327272917943613 2.51002064529902e-06 NA NA NA hsa-miR-141-3p PLEK 5.02396127982626 2.19224509139725e-24 -1.06777187361753 0.0183920114681948 MirTarget;TargetScan -0.416536150215066 5.28530186133013e-26 NA NA NA hsa-miR-141-3p PLXDC1 5.02396127982626 2.19224509139725e-24 0.00175712757885371 0.994886591921339 TargetScan -0.170965597655904 4.42601030183858e-12 NA NA NA hsa-miR-141-3p PLXNA4 5.02396127982626 2.19224509139725e-24 -2.25456361904941 4.96438419774251e-05 TargetScan;miRNATAP -0.601006964484541 9.07505928234085e-37 NA NA NA hsa-miR-141-3p PLXNC1 5.02396127982626 2.19224509139725e-24 -0.532339572840622 0.284697523094741 TargetScan;miRNATAP -0.419915469975757 8.28969677413453e-22 NA NA NA hsa-miR-141-3p PMP2 5.02396127982626 2.19224509139725e-24 -5.56668654102548 1.59099235313416e-29 MirTarget -0.47509254605832 1.06847142693911e-24 NA NA NA hsa-miR-210-3p POU2AF1 6.07079758655679 2.22120227133377e-28 -1.46755689949793 0.0109293207761814 MirTarget -0.281143675042498 1.66972066102077e-09 NA NA NA hsa-miR-141-3p PPFIBP1 5.02396127982626 2.19224509139725e-24 -0.621062569088301 0.00342767338822481 MirTarget -0.124598490344997 9.9593340960011e-11 NA NA NA hsa-miR-141-3p PPM1K 5.02396127982626 2.19224509139725e-24 -1.58286610479163 4.19807618138075e-10 MirTarget -0.232563766177752 7.1110964214171e-25 NA NA NA hsa-miR-141-3p PRDM16 5.02396127982626 2.19224509139725e-24 -2.56004666228196 1.1360029849919e-06 mirMAP -0.285615772222806 3.77579221461135e-09 NA NA NA hsa-miR-141-3p PRELP 5.02396127982626 2.19224509139725e-24 -4.33165618526589 1.8885949692004e-15 mirMAP -0.583968584944458 8.1167541065303e-34 NA NA NA hsa-miR-141-3p PRICKLE1 5.02396127982626 2.19224509139725e-24 -1.64440101214105 0.000132852800511825 TargetScan -0.396289457266669 8.83434530890621e-26 NA NA NA hsa-miR-141-3p PRKAA2 5.02396127982626 2.19224509139725e-24 -3.1651157275578 4.06046613880045e-09 mirMAP -0.311674641790567 3.76173236669185e-10 NA NA NA hsa-miR-141-3p PRKACB 5.02396127982626 2.19224509139725e-24 -1.11910356116881 7.24897707751757e-07 MirTarget;TargetScan;miRNATAP -0.131248917259806 2.40182503281301e-10 NA NA NA hsa-miR-141-3p PRKD1 5.02396127982626 2.19224509139725e-24 -1.53164811371414 4.119038025094e-05 MirTarget;TargetScan -0.237495524984123 2.75579921362746e-12 NA NA NA hsa-miR-210-3p PROK1 6.07079758655679 2.22120227133377e-28 -2.26546093581453 3.24205405707097e-05 MirTarget -0.247463304325384 2.71732353207776e-08 NA NA NA hsa-miR-141-3p PRRT2 5.02396127982626 2.19224509139725e-24 -1.59688997506932 1.79697445742208e-07 mirMAP -0.126860296680001 8.38284619506957e-06 NA NA NA hsa-miR-141-3p PTP4A1 5.02396127982626 2.19224509139725e-24 -0.886199664882353 4.27122299209568e-05 TargetScan;miRNATAP -0.107658681672777 6.31240831148277e-08 NA NA NA hsa-miR-141-3p PTPRD 5.02396127982626 2.19224509139725e-24 -3.62979486144354 1.88740064210481e-09 miRNAWalker2_validate;TargetScan;miRNATAP -0.584125755153581 7.51406235840796e-28 NA NA NA hsa-miR-141-3p PTPRG 5.02396127982626 2.19224509139725e-24 -0.659570164498502 0.0398812996716316 MirTarget;TargetScan;miRNATAP -0.201132411796231 3.96262000395438e-12 NA NA NA hsa-miR-141-3p PXK 5.02396127982626 2.19224509139725e-24 -1.04685086128216 1.54718294430705e-05 MirTarget;TargetScan -0.193272651927338 4.38086874952318e-19 NA NA NA hsa-miR-141-3p QKI 5.02396127982626 2.19224509139725e-24 -0.459712923996318 0.00440824124371165 TargetScan -0.132360282337828 1.6791400486828e-20 NA NA NA hsa-miR-141-3p RAB30 5.02396127982626 2.19224509139725e-24 -1.46673818899504 1.29730263099078e-07 TargetScan;miRNATAP -0.23300147587448 7.08228298452366e-21 NA NA NA hsa-miR-141-3p RAD54L2 5.02396127982626 2.19224509139725e-24 -0.815712955264482 0.00569192771172011 TargetScan -0.113896459197961 2.77631892360301e-05 NA NA NA hsa-miR-141-3p RAPGEF5 5.02396127982626 2.19224509139725e-24 -0.580986175597244 0.0366906480299328 MirTarget -0.141329721270982 2.51336087847175e-08 NA NA NA hsa-miR-141-3p RARB 5.02396127982626 2.19224509139725e-24 -1.77858429602091 2.28807354868447e-06 TargetScan;miRNATAP -0.304531803254532 1.62106913139083e-19 NA NA NA hsa-miR-141-3p RASA4 5.02396127982626 2.19224509139725e-24 -1.1892508233376 1.32902275444348e-05 mirMAP -0.119498282223186 2.20769572742455e-06 NA NA NA hsa-miR-141-3p RASSF2 5.02396127982626 2.19224509139725e-24 -1.41203583911444 3.41019630784437e-05 miRNAWalker2_validate -0.157926960511219 5.03862422283406e-07 NA NA NA hsa-miR-141-3p RASSF8 5.02396127982626 2.19224509139725e-24 -1.48887021923134 4.62579164697906e-06 TargetScan -0.311148360551181 7.8439318105715e-28 NA NA NA hsa-miR-141-3p RBM20 5.02396127982626 2.19224509139725e-24 -2.46227191748389 1.31938346873951e-07 TargetScan -0.236201470484319 4.61015753528414e-08 NA NA NA hsa-miR-141-3p RBM24 5.02396127982626 2.19224509139725e-24 -4.71296042197799 2.54821528082855e-19 TargetScan -0.658965509843211 3.12237554235179e-48 NA NA NA hsa-miR-141-3p RBM7 5.02396127982626 2.19224509139725e-24 -0.635938038315606 2.10598323164864e-05 MirTarget;TargetScan;miRNATAP -0.107318080211912 1.47935679368622e-15 NA NA NA hsa-miR-141-3p RFTN1 5.02396127982626 2.19224509139725e-24 -0.515091372232221 0.0525029974344917 MirTarget -0.227638891906773 1.75169853730135e-22 NA NA NA hsa-miR-141-3p RGS7BP 5.02396127982626 2.19224509139725e-24 -2.88914091526269 2.34477447109264e-08 TargetScan;miRNATAP -0.211449117549126 1.2027138373104e-05 NA NA NA hsa-miR-141-3p RHOBTB1 5.02396127982626 2.19224509139725e-24 -0.383169433464755 0.113831800791812 TargetScan;miRNATAP -0.113091323194795 3.22638694537484e-07 NA NA NA hsa-miR-141-3p RIMBP2 5.02396127982626 2.19224509139725e-24 -2.69405047193145 5.63343241147361e-07 mirMAP -0.37984022246925 8.07929141975062e-15 NA NA NA hsa-miR-141-3p RIMS1 5.02396127982626 2.19224509139725e-24 -2.8928144101207 1.04553689329747e-08 MirTarget;TargetScan -0.242239428864956 2.60255661814804e-07 NA NA NA hsa-miR-141-3p RIMS3 5.02396127982626 2.19224509139725e-24 -1.42027619315578 3.00440701262036e-05 mirMAP -0.220452503245957 1.02693817231772e-12 NA NA NA hsa-miR-141-3p RNF115 5.02396127982626 2.19224509139725e-24 -0.493974122722622 0.0005440404885441 TargetScan -0.118566602984434 5.68680615752015e-21 NA NA NA hsa-miR-141-3p RNF145 5.02396127982626 2.19224509139725e-24 -1.13456828501773 4.01788098713681e-06 MirTarget;TargetScan;miRNATAP -0.166889329474487 7.91018859563463e-14 NA NA NA hsa-miR-141-3p RNF217 5.02396127982626 2.19224509139725e-24 -1.13715450185669 0.0097437081213251 mirMAP -0.265655612126002 2.76054040770475e-11 NA NA NA hsa-miR-141-3p RORA 5.02396127982626 2.19224509139725e-24 -1.82057461685128 1.16708465709096e-09 MirTarget;TargetScan;miRNATAP -0.2095334795559 1.95769501043743e-14 NA NA NA hsa-miR-141-3p RSAD2 5.02396127982626 2.19224509139725e-24 1.09050448915747 0.0183343807979865 MirTarget -0.132649867541437 0.0019213852285425 NA NA NA hsa-miR-141-3p RSPO2 5.02396127982626 2.19224509139725e-24 -3.93336099497493 9.57664391177405e-09 MirTarget -0.690123556120629 1.43585648200077e-30 NA NA NA hsa-miR-141-3p RSPO3 5.02396127982626 2.19224509139725e-24 -3.95134870437563 1.03895511845116e-08 TargetScan -0.808555175879442 2.02316236051444e-43 NA NA NA hsa-miR-141-3p RTN4RL1 5.02396127982626 2.19224509139725e-24 -1.53902047251327 0.00925768188843252 TargetScan -0.194438650090712 0.000373771138806894 NA NA NA hsa-miR-210-3p SCARA3 6.07079758655679 2.22120227133377e-28 -1.80909791414434 3.30952665457699e-05 MirTarget -0.276814578754791 2.27886426319528e-15 NA NA NA hsa-miR-141-3p SCD5 5.02396127982626 2.19224509139725e-24 -1.12475299400773 0.00624411697003686 TargetScan -0.240125902404556 1.32734052396633e-10 NA NA NA hsa-miR-141-3p SCHIP1 5.02396127982626 2.19224509139725e-24 -1.15670143162604 1.15787017339655e-06 MirTarget;TargetScan -0.214489615338193 1.9767324070416e-24 NA NA NA hsa-miR-210-3p SCN1B 6.07079758655679 2.22120227133377e-28 -2.06795854735244 3.41501873074008e-08 miRNAWalker2_validate -0.324210356787498 1.42331107565226e-28 NA NA NA hsa-miR-141-3p SCN2B 5.02396127982626 2.19224509139725e-24 -4.29366513636715 3.96960287530702e-15 MirTarget;miRNATAP -0.638194361703234 2.14387468321129e-41 NA NA NA hsa-miR-141-3p SCN7A 5.02396127982626 2.19224509139725e-24 -6.11978160757835 2.73266450670551e-23 TargetScan -0.646026492790804 8.01655537553871e-31 NA NA NA hsa-miR-141-3p SCN9A 5.02396127982626 2.19224509139725e-24 -1.38434426315237 0.00934391039271171 TargetScan -0.283729563080483 5.27232326685952e-09 NA NA NA hsa-miR-141-3p SDC2 5.02396127982626 2.19224509139725e-24 -2.00706478458987 1.28300608152733e-09 MirTarget;TargetScan -0.310783666482765 3.28501520743697e-26 NA NA NA hsa-miR-141-3p SDK2 5.02396127982626 2.19224509139725e-24 -1.5208913772195 0.00193103042800784 mirMAP -0.121356658714764 0.00771224223698089 NA NA NA hsa-miR-141-3p SERINC1 5.02396127982626 2.19224509139725e-24 -1.06295473287643 5.49350211423462e-13 TargetScan -0.130431422061671 8.42733307068602e-23 NA NA NA hsa-miR-141-3p SETBP1 5.02396127982626 2.19224509139725e-24 -2.26227903514797 8.87237114441678e-09 miRNATAP -0.347927487477622 3.86550056477612e-23 NA NA NA hsa-miR-141-3p SH2B3 5.02396127982626 2.19224509139725e-24 -0.500441864762738 0.0325665390937359 MirTarget -0.226410213969775 4.19058191235717e-29 NA NA NA hsa-miR-210-3p SH3BGRL 6.07079758655679 2.22120227133377e-28 -1.43100123895073 2.53257963935967e-09 MirTarget -0.168458515572699 2.38969389314932e-18 NA NA NA hsa-miR-141-3p SH3PXD2B 5.02396127982626 2.19224509139725e-24 -0.53998931418926 0.0139175585788792 mirMAP -0.179780699601216 1.95459017815311e-20 NA NA NA hsa-miR-141-3p SHE 5.02396127982626 2.19224509139725e-24 -2.12174612226388 6.45456472105851e-13 mirMAP -0.326614936882251 4.73184300032631e-37 NA NA NA hsa-miR-141-3p SIDT2 5.02396127982626 2.19224509139725e-24 -0.567487094559555 0.000188317708359004 TargetScan -0.122225200019388 1.35110713577519e-19 NA NA NA hsa-miR-141-3p SIGLEC1 5.02396127982626 2.19224509139725e-24 -0.883561500953726 0.0567098450341222 mirMAP -0.412785562481062 2.55871079902601e-24 NA NA NA hsa-miR-141-3p SLC16A7 5.02396127982626 2.19224509139725e-24 -2.19116423885911 1.90683758447503e-07 MirTarget;TargetScan;miRNATAP -0.212304427193396 4.98656876124468e-08 NA NA NA hsa-miR-141-3p SLC18A2 5.02396127982626 2.19224509139725e-24 -2.15025936730909 8.02147349359406e-07 TargetScan -0.332963569751475 2.38258210225741e-17 NA NA NA hsa-miR-141-3p SLC1A7 5.02396127982626 2.19224509139725e-24 -1.52314391957885 0.00854832871092879 MirTarget -0.159838803306678 0.00288878558850445 NA NA NA hsa-miR-141-3p SLC6A17 5.02396127982626 2.19224509139725e-24 0.941104200796897 0.0568131902197341 miRNATAP -0.281974703353835 3.24996818288571e-10 NA NA NA hsa-miR-141-3p SLC6A9 5.02396127982626 2.19224509139725e-24 -0.447894573870129 0.140243510464252 MirTarget;TargetScan;miRNATAP -0.173302451949557 3.06109998163885e-10 NA NA NA hsa-miR-141-3p SNAP25 5.02396127982626 2.19224509139725e-24 -1.14591384974572 0.0327342558924054 TargetScan -0.415223382838874 3.37769006907081e-18 NA NA NA hsa-miR-141-3p SOBP 5.02396127982626 2.19224509139725e-24 -3.18866782050437 2.41809868609214e-18 MirTarget;TargetScan -0.382546629954663 1.19835856525009e-31 NA NA NA hsa-miR-141-3p SORBS2 5.02396127982626 2.19224509139725e-24 -3.6862885145227 2.51155368959194e-15 MirTarget;TargetScan -0.289514379293369 3.3173229682062e-11 NA NA NA hsa-miR-141-3p SOX17 5.02396127982626 2.19224509139725e-24 -2.94798887132292 6.52451561011194e-21 TargetScan -0.256726942553231 1.9475675823917e-18 22921431 Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer; MicroRNA 141 was also found to down-regulate SOX17 expression and activate the WNT signal pathway esophageal cancer hsa-miR-141-3p SOX5 5.02396127982626 2.19224509139725e-24 -2.80899915084138 3.69546336813367e-12 TargetScan;miRNATAP -0.33437484410152 8.78039970287997e-20 NA NA NA hsa-miR-141-3p SOX6 5.02396127982626 2.19224509139725e-24 -2.16170894059309 7.49520430040923e-06 TargetScan;mirMAP -0.153973602739025 0.000616698218830245 NA NA NA hsa-miR-141-3p SPN 5.02396127982626 2.19224509139725e-24 -1.0962197092516 0.00559106860717586 mirMAP -0.264085380015187 1.33910289632965e-13 NA NA NA hsa-miR-141-3p SPOCK2 5.02396127982626 2.19224509139725e-24 -0.420533703560178 0.249689356708977 TargetScan;miRNATAP -0.147135893584673 1.12681361701074e-05 NA NA NA hsa-miR-141-3p SPRED1 5.02396127982626 2.19224509139725e-24 -0.64004595524649 0.00626859347930208 miRNATAP -0.172766117206038 1.51843479785622e-16 NA NA NA hsa-miR-141-3p SSTR1 5.02396127982626 2.19224509139725e-24 -4.05163916158795 1.40315760741537e-13 mirMAP -0.279903649938154 5.62031507156795e-08 NA NA NA hsa-miR-141-3p ST3GAL3 5.02396127982626 2.19224509139725e-24 -1.09370616658902 5.68245266413635e-09 MirTarget;TargetScan;miRNATAP -0.174247098126514 1.06036590974725e-25 NA NA NA hsa-miR-141-3p ST6GALNAC3 5.02396127982626 2.19224509139725e-24 -2.04578308207892 3.03442932816697e-11 mirMAP -0.271703112243442 9.6877521130857e-23 NA NA NA hsa-miR-141-3p STAT4 5.02396127982626 2.19224509139725e-24 -0.54405037149823 0.200971233130196 MirTarget;TargetScan -0.226416599746781 4.86462094089995e-09 24732377 Down regulation of miR 141 induced by helicobacter pylori promotes the invasion of gastric cancer by targeting STAT4; A luciferase assay revealed that miR-141 was directly bound to the 3'-untranslated regions 3'-UTR of STAT4; Over-expression of STAT4 was used to mimic miR-141 action in the invasion of gastric cancer; MiR-141 may play a pivotal role in controlling gastric cancer invasion through regulating STAT4 and maybe a potential target to treat gastric cancer gastric cancer hsa-miR-141-3p STAT5A 5.02396127982626 2.19224509139725e-24 -0.684955697233733 0.000967420523261131 MirTarget;TargetScan;miRNATAP -0.106493543449922 2.02111667301054e-08 25241899 Progesterone downregulation of miR 141 contributes to expansion of stem like breast cancer cells through maintenance of progesterone receptor and Stat5a; miR-141 directly targeted both PR and signal transducer and activator of transcription 5A Stat5a transcription factors important for MaSC expansion; These data support a mechanism by which P4-triggered loss of miR-141 facilitates breast cancer cell de-differentiation through deregulation of PR and Stat5a two transcription factors important for controlling mammary cell fate differentiation breast cancer hsa-miR-141-3p STC1 5.02396127982626 2.19224509139725e-24 -1.55340441030689 1.29077994156941e-05 miRNATAP -0.245072762381181 3.11072307709133e-14 NA NA NA hsa-miR-141-3p STX2 5.02396127982626 2.19224509139725e-24 -1.46584536494264 3.15752373756685e-06 MirTarget;TargetScan;miRNATAP -0.386796171821318 7.33479157194817e-50 NA NA NA hsa-miR-141-3p STXBP1 5.02396127982626 2.19224509139725e-24 -1.49894536197603 7.34819776156861e-06 MirTarget;TargetScan;miRNATAP -0.318342374652401 1.56294526587707e-27 NA NA NA hsa-miR-141-3p SULF2 5.02396127982626 2.19224509139725e-24 -0.318781799553761 0.520788272909574 MirTarget -0.375606637925405 1.72800283086241e-17 NA NA NA hsa-miR-141-3p SV2B 5.02396127982626 2.19224509139725e-24 -2.33341367960543 7.07116491599061e-05 MirTarget -0.545453418281659 3.24619539940022e-26 NA NA NA hsa-miR-141-3p SVIL 5.02396127982626 2.19224509139725e-24 -2.03948426821405 7.95203036996479e-13 miRNATAP -0.254445990921425 3.82583157040091e-23 NA NA NA hsa-miR-141-3p SYNPO2 5.02396127982626 2.19224509139725e-24 -5.28154477225055 4.72834649465785e-23 TargetScan;miRNATAP -0.615747260821091 3.09163015048226e-38 NA NA NA hsa-miR-141-3p TBC1D16 5.02396127982626 2.19224509139725e-24 -0.000723386575430585 0.997052256137848 mirMAP -0.108313975787591 9.92125850639723e-10 NA NA NA hsa-miR-141-3p TCF21 5.02396127982626 2.19224509139725e-24 -4.43944664880256 2.76743163205812e-24 TargetScan -0.306185746628777 1.9209178624363e-13 NA NA NA hsa-miR-141-3p TCF4 5.02396127982626 2.19224509139725e-24 -1.61270531688003 6.6047419057989e-09 MirTarget;TargetScan;miRNATAP -0.304690886225458 4.13552081488736e-37 NA NA NA hsa-miR-141-3p TCF7L1 5.02396127982626 2.19224509139725e-24 -1.29563210038614 0.00022110689990566 miRNAWalker2_validate -0.292690799524826 5.33572896586791e-21 NA NA NA hsa-miR-141-3p TEAD1 5.02396127982626 2.19224509139725e-24 -1.49495998391161 1.96516757915294e-13 mirMAP -0.187805911792407 8.82877169341974e-25 NA NA NA hsa-miR-141-3p TGFB2 5.02396127982626 2.19224509139725e-24 -1.19931727990522 0.00330886829654418 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.360699351018386 8.70106540908034e-24 NA NA NA hsa-miR-141-3p THSD4 5.02396127982626 2.19224509139725e-24 -2.37339687749734 3.92006931404185e-13 MirTarget -0.192965155028483 2.59747813165281e-10 NA NA NA hsa-miR-141-3p THSD7A 5.02396127982626 2.19224509139725e-24 -1.95966066744565 2.0548196242739e-05 TargetScan -0.307455997998184 1.83199358211831e-13 NA NA NA hsa-miR-141-3p TLN2 5.02396127982626 2.19224509139725e-24 -1.13678695432202 2.37164982459728e-06 TargetScan -0.133980397958337 1.39258991252499e-09 NA NA NA hsa-miR-141-3p TMEFF1 5.02396127982626 2.19224509139725e-24 0.0710507292015887 0.799522125765303 MirTarget -0.149910716942084 3.56296039416296e-09 NA NA NA hsa-miR-141-3p TMEM108 5.02396127982626 2.19224509139725e-24 -2.78114300571125 1.45650573276381e-06 mirMAP -0.462799291214587 4.10868332497736e-19 NA NA NA hsa-miR-141-3p TMEM130 5.02396127982626 2.19224509139725e-24 -1.78163356079971 0.000643193183477071 MirTarget;TargetScan -0.334289571290283 1.63725866480439e-12 NA NA NA hsa-miR-141-3p TMEM170B 5.02396127982626 2.19224509139725e-24 -0.889417316317811 0.00246966185092237 MirTarget;TargetScan;miRNATAP -0.132246513471541 9.57444558729234e-07 NA NA NA hsa-miR-141-3p TNFAIP3 5.02396127982626 2.19224509139725e-24 -1.62509801593269 1.6029261418853e-06 TargetScan -0.222404109517195 5.77674703240202e-13 NA NA NA hsa-miR-141-3p TNIK 5.02396127982626 2.19224509139725e-24 -2.15489908889994 1.58503169822866e-07 TargetScan -0.221273329247466 5.5726038708684e-09 NA NA NA hsa-miR-141-3p TNRC6C 5.02396127982626 2.19224509139725e-24 -1.19322170447823 2.76418571357645e-08 TargetScan;mirMAP -0.115377463729981 6.13721579740595e-09 NA NA NA hsa-miR-141-3p TNS1 5.02396127982626 2.19224509139725e-24 -3.79443812838711 2.14081599635649e-21 MirTarget;TargetScan -0.529205503273538 1.76374374915486e-54 NA NA NA hsa-miR-141-3p TNS3 5.02396127982626 2.19224509139725e-24 -0.103104493452801 0.668815191833344 MirTarget;TargetScan;miRNATAP -0.117250884574246 9.22998466951585e-08 NA NA NA hsa-miR-141-3p TRAM2 5.02396127982626 2.19224509139725e-24 -0.480560165227073 0.0151980825679313 MirTarget;TargetScan -0.200979225734952 2.00920794817633e-32 NA NA NA hsa-miR-141-3p TSHZ3 5.02396127982626 2.19224509139725e-24 -2.3826164042391 2.29782206551949e-10 MirTarget;TargetScan;miRNATAP -0.448354771292657 5.57469367444821e-45 NA NA NA hsa-miR-141-3p TSPAN4 5.02396127982626 2.19224509139725e-24 -1.20536056884068 4.07284626770108e-05 TargetScan -0.330035805169462 2.97467780076062e-40 NA NA NA hsa-miR-141-3p TTBK2 5.02396127982626 2.19224509139725e-24 -1.27061033500643 8.20749802166803e-07 MirTarget -0.139297581650302 4.35213465937124e-09 NA NA NA hsa-miR-141-3p TTC28 5.02396127982626 2.19224509139725e-24 -1.4343015117923 3.9286632197558e-07 TargetScan -0.128689284653316 9.22590583489215e-07 NA NA NA hsa-miR-141-3p TTLL7 5.02396127982626 2.19224509139725e-24 -2.52056504173714 1.06526045035507e-07 MirTarget;TargetScan -0.339365664154721 3.49014676599148e-15 NA NA NA hsa-miR-141-3p TTYH2 5.02396127982626 2.19224509139725e-24 -1.237079098584 0.000499317051106929 TargetScan;miRNATAP -0.324531910641359 2.04005153817933e-25 NA NA NA hsa-miR-141-3p UACA 5.02396127982626 2.19224509139725e-24 -0.184212642048497 0.302812191960566 TargetScan -0.103079751074141 1.76101840320328e-10 NA NA NA hsa-miR-141-3p UNC5C 5.02396127982626 2.19224509139725e-24 -2.85842438529154 7.1455313233325e-10 MirTarget;TargetScan -0.490431587291333 6.36258343774736e-34 NA NA NA hsa-miR-141-3p VCAN 5.02396127982626 2.19224509139725e-24 0.102699847387805 0.827138258538118 MirTarget;TargetScan;miRNATAP -0.368944305303294 8.18079315504103e-19 NA NA NA hsa-miR-141-3p WDFY4 5.02396127982626 2.19224509139725e-24 -1.52835958077685 0.00208595788951407 mirMAP -0.442972356362165 3.04952593629735e-24 NA NA NA hsa-miR-141-3p WDR31 5.02396127982626 2.19224509139725e-24 -0.638768153831783 0.0652199978514125 TargetScan -0.103964375098238 0.0011483530328461 NA NA NA hsa-miR-141-3p WDR44 5.02396127982626 2.19224509139725e-24 -0.618746968114829 0.00104356284659586 MirTarget;miRNATAP -0.100755126448433 4.90681812652661e-09 NA NA NA hsa-miR-141-3p WIPF1 5.02396127982626 2.19224509139725e-24 -1.36396473341553 1.25828143739996e-05 MirTarget;TargetScan;miRNATAP -0.370961510650937 6.77544747234292e-46 NA NA NA hsa-miR-141-3p WWC2 5.02396127982626 2.19224509139725e-24 -0.762253212847515 0.00511431449708885 mirMAP -0.180337214768461 2.04755740891876e-13 NA NA NA hsa-miR-141-3p WWTR1 5.02396127982626 2.19224509139725e-24 -1.56733544291317 4.73134165029796e-08 MirTarget;TargetScan;miRNATAP -0.305882494344842 5.69456849157899e-35 NA NA NA hsa-miR-210-3p XIST 6.07079758655679 2.22120227133377e-28 -2.3960794008542 0.0565558740952364 miRTarBase -0.273614152195619 0.00806042955759993 NA NA NA hsa-miR-141-3p YAP1 5.02396127982626 2.19224509139725e-24 -0.819514922156015 7.72909626929227e-05 MirTarget;TargetScan -0.107645543722487 1.48207382564769e-08 21289630 MicroRNA 141 confers resistance to cisplatin induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma; Furthermore we found that miR-141 directly targeted the 3'-untranslated region of YAP1 which is known to have a crucial role in apoptosis induced by DNA-damaging agents and thus downregulated YAP1 expression drug resistance esophageal cancer hsa-miR-141-3p ZBED3 5.02396127982626 2.19224509139725e-24 -0.907237805146047 0.00377148523945498 mirMAP -0.122256821649953 2.2748260545844e-05 NA NA NA hsa-miR-141-3p ZBTB16 5.02396127982626 2.19224509139725e-24 -4.69496897387157 4.31130951508901e-16 TargetScan -0.48291304862009 8.49491749838432e-20 NA NA NA hsa-miR-141-3p ZBTB20 5.02396127982626 2.19224509139725e-24 -1.43804710029372 8.52102753381236e-08 MirTarget;TargetScan -0.122693460125016 8.66598183953896e-07 NA NA NA hsa-miR-141-3p ZBTB46 5.02396127982626 2.19224509139725e-24 -0.658672030651983 0.0084554305408128 TargetScan -0.149961532692541 3.73107001017367e-11 NA NA NA hsa-miR-141-3p ZCCHC24 5.02396127982626 2.19224509139725e-24 -2.70719377368971 1.38525107553668e-17 MirTarget;TargetScan;miRNATAP -0.430649507462384 8.6364775253421e-60 NA NA NA hsa-miR-141-3p ZDHHC15 5.02396127982626 2.19224509139725e-24 -2.821890119317 1.80193983474815e-08 MirTarget -0.377496799271016 1.03308793727144e-16 NA NA NA hsa-miR-141-3p ZEB1 5.02396127982626 2.19224509139725e-24 -2.59416392469398 4.19342616481451e-16 miRNAWalker2_validate;miRTarBase;MirTarget;TargetScan;miRNATAP -0.454590307809987 3.89274905091345e-69 24424572;24307282;26783187 Accordingly the enforced expression of miR-200c and mir-141 resulted in a significant upregulation in E-cadherin expression contrary to the significant downregulation in ZEB1 expression in 3 cell lines UTSCC-24A UTSCC-24B and UTSCC-6A cells;It is estimated that miR-141 played its role via ZEB1 and ZEB2; In all miR-141 played a osteosarcoma-suppressing role via ZEB1 and ZEB2;Nintedanib was able to reverse TGF-β1-induced EMT and resistance to gefitinib caused by miR-200b and miR-141 upregulation and ZEB1 downregulation ;;drug resistance head and neck cancer;sarcoma;lung squamous cell cancer hsa-miR-141-3p ZEB2 5.02396127982626 2.19224509139725e-24 -2.26388876645177 1.13775147583663e-12 miRNAWalker2_validate;miRTarBase;MirTarget;miRNATAP -0.457292723841066 1.19552890420513e-72 25975736;18925646;24307282 These results suggest that miR‑141 may be involved in the inhibition of gastric cancer cell migration and that ZEB2 is a target gene of miR-141;TargetScan algorithm revealed that ZFHX1B mRNA is a hypothetical target of both miR-141 and -200c; We established by quantitative RT-PCR that in CCCs in which miR-141 and miR-200c were down-regulated ZFHX1B a transcriptional repressor for CDH1/E-cadherin tended to be up-regulated; On the basis of these findings we suggest that down-regulation of miR-141 and miR-200c in CCCs might be involved in suppression of CDH1/E-cadherin transcription via up-regulation of ZFHX1B;It is estimated that miR-141 played its role via ZEB1 and ZEB2; In all miR-141 played a osteosarcoma-suppressing role via ZEB1 and ZEB2 cell migration;; gastric cancer;kidney renal cell cancer;sarcoma hsa-miR-141-3p ZFP37 5.02396127982626 2.19224509139725e-24 -0.810062916275531 0.0701924167642926 mirMAP -0.107785073955837 0.00921515771520328 NA NA NA hsa-miR-141-3p ZFPM2 5.02396127982626 2.19224509139725e-24 -3.29884457958359 4.34537841593148e-12 miRNAWalker2_validate;miRTarBase -0.591845819504785 3.53269529968965e-49 NA NA NA hsa-miR-141-3p ZNF281 5.02396127982626 2.19224509139725e-24 0.0416620203780278 0.888110347621826 TargetScan -0.13170223961539 1.13014383161302e-06 NA NA NA hsa-miR-141-3p ZNF385D 5.02396127982626 2.19224509139725e-24 -2.94693702740533 2.33707811164882e-08 MirTarget;TargetScan -0.448822778764785 2.25888897773164e-21 NA NA NA hsa-miR-141-3p ZNF423 5.02396127982626 2.19224509139725e-24 -1.58042037965747 5.91645417503201e-05 mirMAP -0.13618213127291 0.000192788876232564 NA NA NA hsa-miR-210-3p ZNF462 6.07079758655679 2.22120227133377e-28 -1.2376798239588 0.00042923519658483 MirTarget -0.111452041715297 0.000113721250476468 NA NA NA hsa-miR-141-3p ZNF516 5.02396127982626 2.19224509139725e-24 -1.70455112707834 2.41525896684444e-07 TargetScan;miRNATAP -0.147891193929967 1.39933363976451e-06 NA NA NA hsa-miR-141-3p ZNF660 5.02396127982626 2.19224509139725e-24 -1.61536224802332 5.42520418912937e-05 TargetScan -0.155368632021419 2.77427383649447e-05 NA NA NA